# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- APH PF01636.23 CRG82658.1 - 7.4e-11 42.4 0.0 2.2e-10 40.9 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 CRG82658.1 - 0.038 13.3 0.0 0.13 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein tyrosine kinase Peptidase_M3_N PF08439.10 CRG82658.1 - 0.12 12.7 1.2 0.34 11.2 0.2 2.3 2 0 0 2 2 2 0 Oligopeptidase F Casc1_N PF15927.5 CRG82658.1 - 1 9.0 8.6 2.5 7.7 8.6 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus AAA PF00004.29 CRG82660.1 - 1.5e-19 70.7 0.0 3.5e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG82660.1 - 9.7e-07 29.1 2.4 0.011 16.0 0.0 3.6 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 CRG82660.1 - 3.7e-05 24.2 3.3 0.00015 22.2 0.4 3.0 3 1 0 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 CRG82660.1 - 0.00015 21.8 0.0 0.00048 20.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CRG82660.1 - 0.00015 22.0 0.0 0.00039 20.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG82660.1 - 0.002 17.9 0.0 0.0042 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CRG82660.1 - 0.0031 16.9 0.0 0.0072 15.7 0.0 1.6 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CRG82660.1 - 0.0035 16.6 0.0 0.0056 15.9 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 CRG82660.1 - 0.0055 16.5 0.0 0.017 14.9 0.0 1.8 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 CRG82660.1 - 0.011 15.5 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 CRG82660.1 - 0.011 15.1 1.1 0.059 12.7 0.1 2.4 3 0 0 3 3 3 0 KaiC AAA_11 PF13086.6 CRG82660.1 - 0.013 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CRG82660.1 - 0.027 14.7 1.5 1.1 9.5 0.0 2.7 1 1 1 2 2 2 0 AAA domain AAA_19 PF13245.6 CRG82660.1 - 0.04 14.2 0.0 0.085 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CRG82660.1 - 0.047 13.4 0.0 0.09 12.5 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 CRG82660.1 - 0.062 13.2 0.2 0.43 10.5 0.0 2.2 1 1 1 2 2 2 0 NACHT domain AAA_24 PF13479.6 CRG82660.1 - 0.075 12.7 0.0 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CRG82660.1 - 0.086 12.3 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CRG82660.1 - 0.11 12.9 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 CRG82660.1 - 0.12 12.9 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CRG82660.1 - 0.14 11.2 0.0 0.29 10.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 CRG82660.1 - 0.16 12.0 0.0 0.46 10.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain Myb_DNA-bind_6 PF13921.6 CRG82661.1 - 0.0019 18.4 1.8 0.004 17.4 1.8 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CRG82661.1 - 0.019 15.1 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 CRG82661.1 - 0.052 13.8 1.5 0.13 12.5 1.5 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain FMO-like PF00743.19 CRG82664.1 - 6.5e-12 44.6 0.3 1.3e-11 43.6 0.0 1.6 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG82664.1 - 9.2e-08 31.7 0.3 1.9e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG82664.1 - 5.3e-06 25.9 0.0 0.00067 19.0 0.0 2.9 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG82664.1 - 4.8e-05 23.5 0.2 0.015 15.5 0.1 2.7 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CRG82664.1 - 0.00016 21.0 0.0 0.0097 15.1 0.0 2.4 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG82664.1 - 0.036 13.6 0.0 9.2 5.7 0.0 2.5 2 0 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 CRG82664.1 - 0.069 12.4 0.1 0.49 9.6 0.0 2.1 2 0 0 2 2 2 0 Thi4 family FAD_binding_3 PF01494.19 CRG82664.1 - 0.11 11.7 0.2 0.23 10.7 0.2 1.5 1 0 0 1 1 1 0 FAD binding domain S-methyl_trans PF02574.16 CRG82665.1 - 1.8e-56 191.9 0.0 2.1e-56 191.7 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase ATP-grasp_4 PF13535.6 CRG82666.1 - 8.2e-12 45.0 0.0 5.3e-11 42.4 0.0 2.3 2 1 0 2 2 2 1 ATP-grasp domain ATPgrasp_N PF18130.1 CRG82666.1 - 2.1e-09 37.8 0.0 4.5e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp N-terminal domain Dala_Dala_lig_C PF07478.13 CRG82666.1 - 5.7e-07 29.3 0.0 7.4e-06 25.6 0.0 2.3 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CRG82666.1 - 0.00014 21.9 0.0 0.0013 18.8 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CRG82666.1 - 0.0024 17.4 0.0 0.0058 16.1 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain GARS_A PF01071.19 CRG82666.1 - 0.0035 17.2 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PTR2 PF00854.21 CRG82667.1 - 2.3e-62 211.1 13.6 3.5e-62 210.5 13.6 1.3 1 0 0 1 1 1 1 POT family Ank_2 PF12796.7 CRG82668.1 - 7.7e-18 64.9 0.0 5.3e-14 52.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG82668.1 - 6.8e-17 61.3 1.4 1.2e-07 31.9 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG82668.1 - 3.6e-16 59.3 0.7 4.6e-07 30.3 0.0 3.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG82668.1 - 2.3e-14 52.1 0.0 0.0024 18.2 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 CRG82668.1 - 1.1e-13 51.0 0.1 0.00023 21.4 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat bZIP_Maf PF03131.17 CRG82668.1 - 0.012 16.1 10.4 0.022 15.3 10.4 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_1 PF00170.21 CRG82668.1 - 0.018 15.1 11.0 0.029 14.5 11.0 1.3 1 0 0 1 1 1 0 bZIP transcription factor Rrn6 PF10214.9 CRG82668.1 - 0.08 11.4 7.3 0.11 11.0 7.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor ODAPH PF15848.5 CRG82669.1 - 0.075 13.5 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Odontogenesis associated phosphoprotein adh_short PF00106.25 CRG82670.1 - 6.2e-23 81.3 0.0 6.8e-20 71.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG82670.1 - 2.7e-11 43.5 0.0 5e-10 39.3 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG82670.1 - 2.7e-07 30.7 0.0 4.2e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 KR domain ATP-grasp_3 PF02655.14 CRG82671.1 - 1.1e-08 35.3 0.0 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 CRG82671.1 - 0.00029 20.5 0.0 0.00055 19.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain DUF3045 PF11243.8 CRG82671.1 - 0.11 12.6 0.7 4.9 7.4 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3045) PALP PF00291.25 CRG82672.1 - 3.5e-43 148.1 3.5 4.1e-43 147.9 3.5 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_25 PF13649.6 CRG82673.1 - 1.3e-18 67.5 0.0 2.5e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG82673.1 - 1.6e-16 60.7 0.0 3.4e-16 59.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG82673.1 - 7.2e-13 48.7 0.0 1.2e-12 48.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG82673.1 - 1.8e-10 40.8 0.0 2.1e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG82673.1 - 2.7e-10 40.9 0.0 4.7e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG82673.1 - 6.5e-06 25.7 0.0 8.2e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 CRG82673.1 - 6.8e-05 22.6 0.0 8.7e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) CMAS PF02353.20 CRG82673.1 - 0.0002 20.7 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 CRG82673.1 - 0.00028 20.4 0.0 0.00037 20.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB CheR PF01739.18 CRG82673.1 - 0.00089 18.8 0.0 0.11 12.0 0.0 2.6 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain N2227 PF07942.12 CRG82673.1 - 0.0038 16.4 0.0 0.007 15.6 0.0 1.4 1 1 0 1 1 1 1 N2227-like protein MTS PF05175.14 CRG82673.1 - 0.0059 16.2 0.0 0.0083 15.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain POR PF01558.18 CRG82673.1 - 0.019 15.1 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Methyltransf_PK PF05891.12 CRG82673.1 - 0.033 13.7 0.0 0.12 11.9 0.0 1.7 1 1 1 2 2 2 0 AdoMet dependent proline di-methyltransferase Methyltransf_10 PF05971.12 CRG82673.1 - 0.055 12.8 0.0 0.075 12.3 0.0 1.1 1 0 0 1 1 1 0 RNA methyltransferase RrnaAD PF00398.20 CRG82673.1 - 0.072 12.1 0.0 0.09 11.8 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase UPF0146 PF03686.13 CRG82673.1 - 0.077 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Pox_MCEL PF03291.16 CRG82673.1 - 0.21 10.6 0.0 2.1 7.4 0.0 2.0 1 1 0 2 2 2 0 mRNA capping enzyme Asp PF00026.23 CRG82674.1 - 1.2e-33 116.9 6.9 1.5e-33 116.6 6.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CRG82674.1 - 0.05 14.3 2.5 0.2 12.3 0.4 3.0 2 2 0 2 2 2 0 Aspartyl protease TAXi_C PF14541.6 CRG82674.1 - 0.08 12.7 0.0 0.35 10.6 0.0 1.9 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal GDPD_2 PF13653.6 CRG82675.1 - 0.088 13.3 0.1 0.19 12.3 0.1 1.6 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Aldo_ket_red PF00248.21 CRG82676.1 - 4.6e-44 150.8 0.0 8.4e-36 123.7 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Cu-oxidase_3 PF07732.15 CRG82677.1 - 2.9e-39 133.8 0.4 2.2e-37 127.7 0.0 3.2 3 1 1 4 4 4 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG82677.1 - 6.8e-28 97.1 0.1 4.5e-26 91.2 0.0 2.9 3 0 0 3 3 3 1 Multicopper oxidase Phosphoesterase PF04185.14 CRG82678.1 - 1.3e-79 267.9 1.8 1.3e-79 267.9 1.8 1.4 2 0 0 2 2 2 1 Phosphoesterase family GST_C_3 PF14497.6 CRG82679.1 - 4.3e-11 42.9 0.1 9.1e-11 41.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CRG82679.1 - 2.6e-05 24.5 0.0 5.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 CRG82679.1 - 0.0012 19.1 0.0 0.0022 18.3 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 CRG82679.1 - 0.0058 17.4 0.0 0.011 16.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C PF00043.25 CRG82679.1 - 0.0079 16.4 0.0 0.025 14.8 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG82679.1 - 0.014 15.7 0.0 0.037 14.4 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG82679.1 - 0.018 15.0 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NAD_binding_6 PF08030.12 CRG82679.1 - 0.17 12.0 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain MFS_1 PF07690.16 CRG82680.1 - 2.3e-14 53.1 41.3 2.3e-14 53.1 41.3 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG82680.1 - 5.9e-13 48.1 13.3 5.9e-13 48.1 13.3 2.0 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) TMEM208_SND2 PF05620.11 CRG82680.1 - 0.3 10.9 12.1 0.17 11.6 4.7 3.3 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Zn_clus PF00172.18 CRG82681.1 - 9.8e-05 22.4 12.2 0.00025 21.1 12.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG82681.1 - 0.00066 18.6 0.1 0.0011 17.9 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DJ-1_PfpI PF01965.24 CRG82682.1 - 1.7e-16 60.4 0.0 3.1e-16 59.6 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family Glyco_hydro_cc PF11790.8 CRG82683.1 - 1.6e-49 168.6 0.9 2.3e-49 168.1 0.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Abhydrolase_6 PF12697.7 CRG82683.1 - 2.1e-17 64.5 0.0 4.4e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG82683.1 - 3.8e-11 42.7 0.0 6e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG82683.1 - 7.4e-09 35.6 0.1 1.4e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CRG82683.1 - 3.5e-08 33.5 0.3 1.5e-07 31.5 0.0 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 CRG82683.1 - 0.011 15.6 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase LIDHydrolase PF10230.9 CRG82683.1 - 0.012 15.2 0.0 0.02 14.5 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase PGAP1 PF07819.13 CRG82683.1 - 0.04 13.6 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Hydrophobin PF01185.18 CRG82684.1 - 8.3e-17 61.6 6.2 1.1e-16 61.2 6.2 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Glyco_hydro_18 PF00704.28 CRG82685.1 - 4.9e-26 92.2 1.2 1.1e-25 91.1 1.2 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 ADH_zinc_N PF00107.26 CRG82686.1 - 0.0083 16.1 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glyco_hydro_18 PF00704.28 CRG82687.1 - 8e-24 84.9 1.1 1.8e-23 83.8 1.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF4434 PF14488.6 CRG82687.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Med13_C PF06333.12 CRG82687.1 - 2.2 7.5 5.8 3.6 6.8 5.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain adh_short_C2 PF13561.6 CRG82688.1 - 4.7e-28 98.3 0.0 1.9e-24 86.5 0.0 3.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG82688.1 - 1e-19 70.8 0.0 5.4e-19 68.4 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG82688.1 - 0.00032 20.7 0.0 0.00067 19.6 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG82688.1 - 0.00033 20.2 0.1 0.017 14.6 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Urotensin_II PF02083.15 CRG82689.1 - 1.2 9.0 3.7 4 7.3 0.5 2.8 2 0 0 2 2 2 0 Urotensin II FA_desaturase PF00487.24 CRG82690.1 - 2.8e-20 73.2 30.3 2.8e-20 73.2 30.3 1.3 1 1 0 1 1 1 1 Fatty acid desaturase Cu-oxidase_2 PF07731.14 CRG82691.1 - 6e-46 155.6 13.6 7.7e-41 139.0 3.4 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG82691.1 - 2.3e-40 137.3 8.5 4.4e-39 133.2 1.4 3.5 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CRG82691.1 - 3.9e-36 124.6 2.1 1.5e-33 116.2 0.6 3.3 3 0 0 3 3 3 1 Multicopper oxidase Cupredoxin_1 PF13473.6 CRG82691.1 - 0.0092 16.1 0.0 2.9 8.1 0.0 3.5 3 1 0 3 3 3 1 Cupredoxin-like domain FTR1 PF03239.14 CRG82692.1 - 7.5e-86 288.1 6.5 8.7e-86 287.8 6.5 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Ldr_toxin PF13940.6 CRG82692.1 - 0.044 13.8 0.2 0.044 13.8 0.2 2.3 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system Tmemb_14 PF03647.13 CRG82692.1 - 0.42 11.4 10.2 4.3 8.1 0.4 2.7 2 0 0 2 2 2 0 Transmembrane proteins 14C DoxX_3 PF13781.6 CRG82692.1 - 0.77 10.4 9.0 0.37 11.4 1.9 2.6 1 1 1 2 2 2 0 DoxX-like family Phage_holin_3_6 PF07332.11 CRG82692.1 - 1.6 8.8 9.5 0.21 11.6 0.9 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3180 PF11377.8 CRG82692.1 - 9.5 6.4 13.5 0.094 12.9 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) MFS_1 PF07690.16 CRG82693.1 - 9.4e-31 107.0 30.2 9.4e-31 107.0 30.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF389 PF04087.14 CRG82693.1 - 0.089 12.8 6.9 5.1 7.1 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF389) Glyco_hydro_3_C PF01915.22 CRG82694.1 - 4.9e-48 163.8 0.3 7.4e-48 163.2 0.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG82694.1 - 7.4e-27 94.6 0.0 1.3e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG82694.1 - 1.1e-05 25.4 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DDR PF08841.10 CRG82694.1 - 0.15 11.1 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain Methyltransf_2 PF00891.18 CRG82695.1 - 1.9e-24 86.2 0.0 3.3e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Sigma70_r4 PF04545.16 CRG82695.1 - 0.031 13.8 0.0 0.083 12.4 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 MFS_1 PF07690.16 CRG82696.1 - 1.3e-24 86.8 46.0 1.9e-23 83.0 45.8 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Glyoxalase PF00903.25 CRG82697.1 - 3.3e-23 82.3 0.1 6.6e-17 61.9 0.0 2.3 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CRG82697.1 - 1.4e-13 51.1 0.0 2.4e-06 27.8 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CRG82697.1 - 3.7e-07 30.4 0.0 0.057 13.5 0.0 3.0 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 CRG82697.1 - 0.0001 22.5 0.0 0.00059 20.0 0.0 2.1 3 0 0 3 3 3 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyoxalase_6 PF18029.1 CRG82697.1 - 0.0081 16.9 0.0 0.24 12.2 0.0 2.4 2 0 0 2 2 2 1 Glyoxalase-like domain DUF948 PF06103.11 CRG82697.1 - 0.21 11.8 1.3 0.35 11.2 0.2 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FeoB_Cyto PF17910.1 CRG82698.1 - 0.027 15.0 0.0 0.063 13.8 0.0 1.8 1 1 0 1 1 1 0 FeoB cytosolic helical domain TPR_17 PF13431.6 CRG82698.1 - 0.036 14.4 0.1 0.2 12.1 0.1 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat FMN_dh PF01070.18 CRG82699.1 - 3.2e-117 391.5 0.1 3.8e-117 391.2 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG82699.1 - 2.2e-18 66.2 0.0 7.6e-18 64.4 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain IMPDH PF00478.25 CRG82699.1 - 2.9e-05 23.2 0.1 0.00013 21.1 0.0 2.1 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CRG82699.1 - 0.00012 21.4 0.0 0.00024 20.3 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase NMO PF03060.15 CRG82699.1 - 0.002 17.6 0.3 0.0054 16.2 0.1 1.7 2 0 0 2 2 2 1 Nitronate monooxygenase His_biosynth PF00977.21 CRG82699.1 - 0.041 13.4 0.1 0.22 11.0 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein Aldedh PF00171.22 CRG82700.1 - 8.3e-83 278.4 0.0 9.4e-83 278.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family SCAPER_N PF16501.5 CRG82700.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum Fungal_trans_2 PF11951.8 CRG82702.1 - 4.3e-61 206.8 1.4 5.4e-61 206.5 1.4 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidase PF01425.21 CRG82703.1 - 8.5e-106 354.6 0.0 1.3e-105 354.0 0.0 1.3 1 0 0 1 1 1 1 Amidase Pyridox_ox_2 PF12900.7 CRG82704.1 - 3.2e-18 66.1 0.2 7.7e-18 64.8 0.2 1.7 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Phage-tail_3 PF13550.6 CRG82704.1 - 0.024 14.5 0.0 0.077 12.8 0.0 1.8 2 0 0 2 2 2 0 Putative phage tail protein MFS_1 PF07690.16 CRG82705.1 - 3.2e-23 82.2 14.8 3.2e-23 82.2 14.8 2.1 1 1 0 2 2 2 1 Major Facilitator Superfamily FtsH_ext PF06480.15 CRG82705.1 - 0.1 13.0 0.4 0.27 11.6 0.4 1.6 1 0 0 1 1 1 0 FtsH Extracellular DIOX_N PF14226.6 CRG82706.1 - 2.3e-18 67.1 0.0 4.3e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG82706.1 - 3.6e-16 59.5 0.0 9.1e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_6 PF12697.7 CRG82707.1 - 4e-06 27.6 1.9 5.5e-06 27.1 1.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Glyco_hydro_76 PF03663.14 CRG82708.1 - 1.9e-143 478.5 30.5 2.7e-143 477.9 30.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 2OG-FeII_Oxy PF03171.20 CRG82708.1 - 3.9e-14 53.0 0.0 1.1e-13 51.5 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG82708.1 - 3.8e-08 34.1 0.0 7.1e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal UbiA PF01040.18 CRG82710.1 - 2.2e-20 73.0 11.7 3.5e-20 72.4 11.7 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Oleosin PF01277.17 CRG82710.1 - 1.9 8.3 4.8 5.3 6.8 2.4 2.4 2 0 0 2 2 2 0 Oleosin DUF2236 PF09995.9 CRG82711.1 - 7.6e-06 26.3 7.1 1.5e-05 25.4 7.1 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) PSP PF04046.16 CRG82711.1 - 0.052 13.4 1.6 0.077 12.9 0.3 1.9 2 0 0 2 2 2 0 PSP p450 PF00067.22 CRG82712.1 - 1.2e-56 192.4 0.0 6.3e-52 176.8 0.0 2.0 1 1 1 2 2 2 2 Cytochrome P450 Peptidase_S58 PF03576.14 CRG82713.1 - 8.6e-111 370.2 1.5 9.8e-111 370.0 1.5 1.0 1 0 0 1 1 1 1 Peptidase family S58 Fungal_trans PF04082.18 CRG82714.1 - 4.2e-10 39.1 0.3 7.2e-10 38.3 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG82714.1 - 7.4e-08 32.4 12.4 1.7e-07 31.3 12.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 CRG82715.1 - 8.3e-07 29.0 6.1 1.6e-06 28.1 6.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_3 PF01494.19 CRG82716.1 - 1.4e-25 90.3 0.0 3.3e-25 89.1 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG82716.1 - 1.3e-07 31.6 1.1 6e-05 22.8 0.9 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG82716.1 - 2.6e-07 30.2 0.0 0.01 15.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG82716.1 - 5.9e-06 26.4 0.3 1.4e-05 25.2 0.3 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG82716.1 - 1.5e-05 25.5 0.1 0.0044 17.6 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG82716.1 - 2.6e-05 23.7 0.0 0.033 13.5 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 CRG82716.1 - 0.00019 20.8 0.3 0.17 11.1 0.1 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG82716.1 - 0.0015 17.7 0.4 0.0062 15.7 0.3 1.8 1 1 1 2 2 2 1 FAD binding domain DUF1727 PF08353.10 CRG82716.1 - 0.0085 16.0 0.1 0.017 15.0 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1727) NAD_binding_9 PF13454.6 CRG82716.1 - 0.035 14.1 0.1 0.17 11.8 0.1 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 CRG82716.1 - 0.045 13.0 0.1 0.068 12.4 0.1 1.2 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CRG82716.1 - 0.08 11.6 0.0 1.3 7.7 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein Trp_halogenase PF04820.14 CRG82716.1 - 0.097 11.5 0.1 22 3.7 0.1 2.9 3 0 0 3 3 3 0 Tryptophan halogenase Lycopene_cycl PF05834.12 CRG82716.1 - 0.2 10.7 0.2 1.2 8.1 0.1 2.2 3 0 0 3 3 3 0 Lycopene cyclase protein Toxin_30 PF08117.11 CRG82718.1 - 0.0064 16.7 0.3 0.0064 16.7 0.3 1.9 2 0 0 2 2 2 1 Ptu family Pro-kuma_activ PF09286.11 CRG82719.1 - 2.8e-50 170.3 0.0 5e-50 169.5 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Zn_clus PF00172.18 CRG82720.1 - 1.7e-07 31.2 12.9 3.6e-07 30.2 12.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 CRG82720.1 - 0.36 11.2 6.7 0.074 13.4 1.6 2.4 2 0 0 2 2 2 0 Opy2 protein His_Phos_1 PF00300.22 CRG82721.1 - 0.0026 17.5 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) zf-BED PF02892.15 CRG82722.1 - 0.0034 17.4 4.0 0.074 13.1 0.2 2.5 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_4 PF13894.6 CRG82722.1 - 4.7 8.3 6.0 2.4 9.2 1.8 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Rrn6 PF10214.9 CRG82723.1 - 5.8 5.3 11.2 6.3 5.1 11.2 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SH3BGR PF04908.15 CRG82724.1 - 0.00037 20.6 1.2 0.0031 17.6 0.0 3.1 2 1 0 3 3 3 1 SH3-binding, glutamic acid-rich protein HSP70 PF00012.20 CRG82724.1 - 3.2 5.8 19.5 4.9 5.2 19.5 1.2 1 0 0 1 1 1 0 Hsp70 protein Paramyxo_ncap PF00973.19 CRG82724.1 - 4.5 6.1 9.7 9.8 5.0 9.7 1.5 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Ribul_P_3_epim PF00834.19 CRG82725.1 - 1.7e-61 207.1 0.0 2e-60 203.6 0.0 2.0 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family ThiG PF05690.14 CRG82725.1 - 0.02 14.2 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG OMPdecase PF00215.24 CRG82725.1 - 0.046 13.3 0.1 0.085 12.4 0.0 1.7 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 CRG82725.1 - 0.11 12.3 0.1 0.44 10.3 0.0 1.9 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Methyltransf_11 PF08241.12 CRG82727.1 - 1.4e-07 32.0 0.0 3.2e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG82727.1 - 0.012 16.3 0.0 0.031 15.0 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain LSM PF01423.22 CRG82728.1 - 2e-17 62.6 0.8 3e-17 62.0 0.8 1.3 1 0 0 1 1 1 1 LSM domain LRR_9 PF14580.6 CRG82728.1 - 0.008 15.7 0.1 0.014 14.9 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat Hfq PF17209.3 CRG82728.1 - 0.039 13.6 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Hfq protein SM-ATX PF14438.6 CRG82728.1 - 0.093 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain Glyco_hydro_11 PF00457.17 CRG82729.1 - 3.8e-62 209.1 10.1 4.7e-62 208.8 10.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 adh_short PF00106.25 CRG82730.1 - 1.2e-48 165.1 0.3 1.7e-48 164.7 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG82730.1 - 3.2e-48 164.3 0.0 4.1e-48 164.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG82730.1 - 8.1e-13 48.7 0.4 1e-12 48.3 0.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG82730.1 - 1.2e-06 28.2 0.2 1.9e-06 27.5 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_5 PF08323.11 CRG82730.1 - 0.012 15.4 0.0 0.27 10.9 0.0 2.1 2 0 0 2 2 2 0 Starch synthase catalytic domain GDP_Man_Dehyd PF16363.5 CRG82730.1 - 0.015 14.7 0.2 0.025 14.0 0.1 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_7 PF13241.6 CRG82730.1 - 0.016 15.6 0.1 0.028 14.9 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3Beta_HSD PF01073.19 CRG82730.1 - 0.022 13.8 0.1 0.029 13.4 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Glyco_trans_4_4 PF13579.6 CRG82730.1 - 0.048 14.1 0.2 14 6.1 0.0 2.4 2 1 0 2 2 2 0 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CRG82730.1 - 0.056 13.4 0.0 7.2 6.6 0.0 2.3 2 1 0 2 2 2 0 Glycosyltransferase Family 4 ApbA PF02558.16 CRG82730.1 - 0.089 12.4 0.7 0.58 9.8 0.2 2.1 1 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA RmlD_sub_bind PF04321.17 CRG82730.1 - 0.11 11.6 0.1 0.21 10.7 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain DUF1815 PF08844.10 CRG82730.1 - 0.13 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1815) Fungal_trans PF04082.18 CRG82731.1 - 0.001 18.2 0.1 0.0011 18.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 CRG82732.1 - 1.1e-16 61.1 0.0 4e-09 36.4 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family Semialdhyde_dh PF01118.24 CRG82732.1 - 0.21 12.0 0.0 0.96 9.9 0.0 2.0 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CRG82732.1 - 0.23 10.9 0.0 0.32 10.4 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family zf-C2H2_4 PF13894.6 CRG82733.1 - 9.3e-06 26.1 20.4 0.00067 20.3 2.2 5.6 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG82733.1 - 0.0002 21.7 19.0 0.22 12.0 0.4 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type Homeodomain PF00046.29 CRG82733.1 - 0.0014 18.4 1.2 0.0034 17.2 0.1 2.2 2 0 0 2 2 2 1 Homeodomain Homeobox_KN PF05920.11 CRG82733.1 - 0.011 15.6 0.0 0.031 14.2 0.0 1.8 1 0 0 1 1 1 0 Homeobox KN domain zf-C2H2_2 PF12756.7 CRG82733.1 - 0.066 13.6 7.3 1.4 9.3 0.0 3.8 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Sugar_tr PF00083.24 CRG82734.1 - 0.028 13.3 0.0 0.032 13.1 0.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter p450 PF00067.22 CRG82736.1 - 1.5e-68 231.7 0.0 1.7e-68 231.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4031 PF13223.6 CRG82736.1 - 0.018 15.2 0.1 4.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4031) Peptidase_M99_m PF17130.4 CRG82736.1 - 0.067 13.1 0.2 7.8 6.5 0.0 2.8 3 0 0 3 3 3 0 beta-barrel domain of carboxypeptidase M99 TPT PF03151.16 CRG82737.1 - 8.9e-23 81.0 20.0 1.1e-22 80.7 20.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CRG82737.1 - 5.3e-07 29.9 33.2 0.00011 22.3 14.9 2.5 2 1 0 2 2 2 2 EamA-like transporter family PBECR3 PF18812.1 CRG82739.1 - 0.077 12.9 0.0 0.56 10.2 0.0 2.1 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 DUF713 PF05218.14 CRG82741.1 - 0.018 14.8 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF713) CENP-F_leu_zip PF10473.9 CRG82741.1 - 0.022 14.8 3.8 0.022 14.8 3.8 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DLP_helical PF18709.1 CRG82741.1 - 0.031 13.5 1.9 0.06 12.5 1.9 1.5 1 0 0 1 1 1 0 Dynamin-like helical domain Fib_alpha PF08702.10 CRG82741.1 - 0.05 13.8 2.0 7 6.8 0.2 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family PLAC9 PF15205.6 CRG82741.1 - 0.068 13.6 0.1 0.34 11.3 0.0 2.2 2 0 0 2 2 1 0 Placenta-specific protein 9 YabA PF06156.13 CRG82741.1 - 0.11 13.1 0.2 0.11 13.1 0.2 2.6 2 1 0 3 3 3 0 Initiation control protein YabA Tropomyosin_1 PF12718.7 CRG82741.1 - 0.16 12.1 9.1 1.6 8.9 0.4 3.1 2 1 1 3 3 3 0 Tropomyosin like DUF16 PF01519.16 CRG82741.1 - 0.23 11.9 3.6 2.7 8.5 0.5 2.5 1 1 2 3 3 3 0 Protein of unknown function DUF16 DUF1664 PF07889.12 CRG82741.1 - 0.31 11.1 1.9 8.2 6.5 0.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 CRG82741.1 - 0.38 9.8 7.6 0.62 9.1 7.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AKNA PF12443.8 CRG82741.1 - 0.7 10.6 0.1 0.7 10.6 0.1 2.9 3 1 1 4 4 3 0 AT-hook-containing transcription factor CAP_N PF01213.19 CRG82741.1 - 0.86 9.0 6.4 7.6 5.9 0.1 2.3 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DUF948 PF06103.11 CRG82741.1 - 2.2 8.6 3.6 8.1 6.8 0.1 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Lebercilin PF15619.6 CRG82741.1 - 4 7.0 14.2 4.5 6.9 7.1 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF2203 PF09969.9 CRG82741.1 - 6.1 7.6 7.4 6 7.6 3.4 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) CENP-Q PF13094.6 CRG82741.1 - 6.2 7.0 12.0 58 3.8 12.0 2.2 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit UPF0242 PF06785.11 CRG82741.1 - 6.3 6.9 8.9 16 5.5 8.9 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 CRG82741.1 - 7.2 6.8 15.3 3.4 7.9 7.8 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Fmp27_WPPW PF10359.9 CRG82741.1 - 9.8 4.9 9.2 78 1.9 9.2 2.1 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain PhyH PF05721.13 CRG82742.1 - 1.4e-25 90.9 0.0 2.1e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HD PF01966.22 CRG82742.1 - 2.1e-05 24.7 0.0 6.1e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 HD domain MIOX PF05153.15 CRG82742.1 - 0.00084 19.0 0.0 0.0039 16.8 0.0 1.9 2 0 0 2 2 2 1 Myo-inositol oxygenase 2OG-FeII_Oxy_5 PF13759.6 CRG82742.1 - 0.0012 19.3 0.0 0.0026 18.1 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 CRG82742.1 - 0.0047 17.8 0.0 0.01 16.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HDOD PF08668.12 CRG82742.1 - 0.016 14.7 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 HDOD domain HD_4 PF13328.6 CRG82742.1 - 0.13 12.0 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 HD domain Sugar_tr PF00083.24 CRG82743.1 - 1.7e-37 129.4 29.4 1.9e-24 86.4 11.5 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG82743.1 - 4.2e-26 91.7 35.4 6.9e-14 51.5 16.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG82743.1 - 0.0041 15.6 0.2 0.0041 15.6 0.2 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_2_4 PF16082.5 CRG82743.1 - 0.077 12.7 0.0 0.27 11.0 0.0 2.0 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like p450 PF00067.22 CRG82744.1 - 4.3e-93 312.6 0.0 5.5e-93 312.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DRMBL PF07522.14 CRG82744.1 - 1.5e-33 115.2 0.0 3.1e-33 114.3 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 CRG82744.1 - 3.5e-06 26.7 0.0 6.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CRG82744.1 - 0.03 14.3 0.0 0.17 11.8 0.0 2.3 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily SMP PF04927.12 CRG82745.1 - 2.8e-13 50.1 2.8 1.5e-06 28.5 0.1 2.4 2 0 0 2 2 2 2 Seed maturation protein DIOX_N PF14226.6 CRG82747.1 - 3.9e-18 66.3 0.0 5.5e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG82747.1 - 4e-17 62.6 0.0 9.9e-17 61.3 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily OPT PF03169.15 CRG82748.1 - 3.9e-178 593.9 55.0 4.5e-178 593.7 55.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4231 PF14015.6 CRG82748.1 - 5.8 7.4 6.0 9.7 6.7 0.0 3.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) Esterase_phd PF10503.9 CRG82749.1 - 4.5e-05 23.0 0.0 0.001 18.6 0.0 2.2 2 0 0 2 2 2 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CRG82749.1 - 6.9e-05 22.4 0.3 0.00033 20.2 0.3 2.0 1 1 1 2 2 2 1 Prolyl oligopeptidase family Esterase PF00756.20 CRG82749.1 - 0.00036 20.3 0.0 0.00061 19.5 0.0 1.4 1 1 0 1 1 1 1 Putative esterase AXE1 PF05448.12 CRG82749.1 - 0.0046 15.7 0.0 2.1 7.0 0.0 2.3 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) MFS_1 PF07690.16 CRG82750.1 - 4.5e-18 65.3 23.9 6.2e-18 64.8 23.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4500 PF14937.6 CRG82750.1 - 0.093 12.8 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) DUF1772 PF08592.11 CRG82750.1 - 0.82 10.0 5.4 1 9.7 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF1772) Thyroglobulin_1 PF00086.18 CRG82751.1 - 0.053 13.2 0.8 0.12 12.1 0.8 1.5 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat Sulfatase PF00884.23 CRG82752.1 - 3.7e-42 144.8 1.1 5.4e-40 137.7 1.1 2.3 1 1 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 CRG82752.1 - 8.3e-08 32.4 0.4 2.7e-07 30.8 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 CRG82752.1 - 5e-07 29.6 0.2 0.0013 18.4 0.0 2.3 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 CRG82752.1 - 0.0056 17.4 0.0 0.014 16.2 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 CRG82752.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Lyase_N PF09092.11 CRG82753.1 - 0.19 11.6 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Lyase, N terminal DUF3712 PF12505.8 CRG82754.1 - 2.8e-29 101.9 0.3 1.4e-28 99.7 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) LEA_2 PF03168.13 CRG82754.1 - 0.01 16.4 0.3 0.053 14.1 0.1 2.2 2 1 0 2 2 2 0 Late embryogenesis abundant protein DUF1279 PF06916.13 CRG82754.1 - 0.021 15.4 0.1 0.04 14.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) DUF2417 PF10329.9 CRG82754.1 - 0.039 13.4 0.0 0.057 12.8 0.0 1.2 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Phosphatase PF15698.5 CRG82754.1 - 0.076 12.1 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Phosphatase Glyco_hydro_62 PF03664.13 CRG82755.1 - 3.1e-132 440.0 10.5 4.4e-132 439.4 10.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 FAD_binding_3 PF01494.19 CRG82756.1 - 1.4e-81 274.5 0.0 2.9e-54 184.6 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Phe_hydrox_dim PF07976.12 CRG82756.1 - 2.4e-34 118.8 0.0 7e-34 117.3 0.0 1.8 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_oxidored PF12831.7 CRG82756.1 - 1.7e-06 27.7 0.1 2.8e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG82756.1 - 2.7e-05 23.5 0.0 4.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CRG82756.1 - 3.6e-05 22.7 0.1 5.4e-05 22.1 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CRG82756.1 - 0.00012 21.3 0.2 0.00019 20.6 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG82756.1 - 0.00012 22.2 0.1 0.00037 20.6 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CRG82756.1 - 0.00056 19.1 0.0 0.00077 18.7 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CRG82756.1 - 0.001 18.4 0.1 0.003 16.9 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG82756.1 - 0.0012 19.4 0.1 0.011 16.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG82756.1 - 0.0013 18.1 0.0 0.0024 17.2 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG82756.1 - 0.0047 16.6 0.0 0.0079 15.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG82756.1 - 0.023 14.0 0.1 0.039 13.2 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CRG82756.1 - 0.029 13.2 0.0 0.04 12.8 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase RES PF08808.11 CRG82756.1 - 0.047 13.6 0.0 0.21 11.5 0.0 2.1 1 1 1 2 2 2 0 RES domain SE PF08491.10 CRG82756.1 - 0.15 11.1 0.0 0.36 9.8 0.0 1.5 1 1 0 1 1 1 0 Squalene epoxidase Methyltransf_24 PF13578.6 CRG82757.1 - 9.2e-11 42.7 0.0 2.1e-10 41.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_3 PF01596.17 CRG82757.1 - 3e-10 39.6 0.0 3.9e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 CRG82757.1 - 0.0061 16.3 0.0 0.0082 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CmcI PF04989.12 CRG82757.1 - 0.034 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Cephalosporin hydroxylase TTL PF03133.15 CRG82758.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Tubulin-tyrosine ligase family GSH-S_ATP PF02955.16 CRG82758.1 - 0.093 12.1 0.0 0.75 9.2 0.0 2.1 1 1 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain IgaA PF07095.11 CRG82758.1 - 0.11 10.4 0.0 0.15 10.0 0.0 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA PRP38 PF03371.15 CRG82759.1 - 0.085 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 PRP38 family Cu-oxidase_3 PF07732.15 CRG82760.1 - 2.8e-39 133.8 2.2 2.8e-39 133.8 2.2 2.5 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG82760.1 - 1e-35 122.4 7.8 3.9e-33 114.1 1.1 3.7 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CRG82760.1 - 9.6e-29 100.5 0.1 2.6e-28 99.2 0.1 1.8 1 0 0 1 1 1 1 Multicopper oxidase Zn_clus PF00172.18 CRG82762.1 - 0.00083 19.4 14.0 0.0013 18.8 14.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GCIP PF13324.6 CRG82762.1 - 0.094 12.3 0.1 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting DUF4611 PF15387.6 CRG82762.1 - 1.5 9.1 7.6 1.6 9.0 0.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) MFS_1 PF07690.16 CRG82763.1 - 4.6e-42 144.2 53.3 6.2e-36 124.0 14.8 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily TRI12 PF06609.13 CRG82763.1 - 1.8e-17 63.1 12.3 6.1e-17 61.3 10.6 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG82763.1 - 2.3e-09 36.6 15.3 2.3e-09 36.6 15.3 3.1 4 1 0 4 4 4 1 Sugar (and other) transporter OATP PF03137.20 CRG82763.1 - 0.83 7.9 12.2 0.034 12.5 3.6 2.4 2 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family EthD PF07110.11 CRG82764.1 - 1.4e-05 26.2 0.1 2e-05 25.7 0.1 1.3 1 0 0 1 1 1 1 EthD domain Abhydrolase_6 PF12697.7 CRG82765.1 - 1.6e-08 35.4 0.9 2.3e-08 34.9 0.2 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG82765.1 - 5.2e-05 22.6 0.1 9.2e-05 21.8 0.1 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CRG82765.1 - 0.00061 19.3 0.0 0.0027 17.2 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CRG82765.1 - 0.00098 18.8 0.0 0.003 17.3 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CRG82765.1 - 0.025 14.4 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold AXE1 PF05448.12 CRG82765.1 - 0.05 12.3 0.0 0.43 9.2 0.0 2.0 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) UPF0227 PF05728.12 CRG82765.1 - 0.054 13.4 0.0 0.087 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) ADH_N PF08240.12 CRG82766.1 - 2e-07 30.9 0.2 2.9e-06 27.1 0.1 2.4 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG82766.1 - 3.6e-06 27.0 0.0 7.9e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CRG82766.1 - 0.04 13.8 0.2 0.12 12.3 0.1 1.7 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase p450 PF00067.22 CRG82767.1 - 6.5e-71 239.5 0.0 7.6e-71 239.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CRG82769.1 - 2.3e-58 198.1 0.0 2.9e-58 197.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HAD_SAK_1 PF10307.9 CRG82769.1 - 0.041 13.7 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 HAD domain family 1 in Swiss Army Knife RNA repair proteins ketoacyl-synt PF00109.26 CRG82770.1 - 6.5e-71 238.9 0.0 1.2e-70 238.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Condensation PF00668.20 CRG82770.1 - 1.1e-61 208.9 0.0 2.2e-61 208.0 0.0 1.4 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 CRG82770.1 - 1.8e-50 171.3 0.0 5.2e-50 169.8 0.0 1.9 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CRG82770.1 - 2.9e-48 165.0 0.0 2.7e-47 161.8 0.0 2.1 2 0 0 2 2 2 1 Acyl transferase domain AMP-binding PF00501.28 CRG82770.1 - 2.3e-47 161.6 0.1 4.7e-47 160.5 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme PS-DH PF14765.6 CRG82770.1 - 1.7e-43 149.0 0.0 2.5e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CRG82770.1 - 4.9e-32 110.4 0.0 1.2e-31 109.2 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG82770.1 - 4.5e-15 56.1 0.0 1.4e-14 54.4 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG82770.1 - 1.7e-12 47.3 0.2 1.4e-11 44.2 0.1 2.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG82770.1 - 1.9e-06 27.6 0.1 8.9e-06 25.4 0.0 2.2 3 0 0 3 3 3 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CRG82770.1 - 2.4e-05 24.6 0.1 7.8e-05 22.9 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site SAT PF16073.5 CRG82770.1 - 0.00058 19.7 0.0 0.0016 18.2 0.0 1.7 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_23 PF13489.6 CRG82770.1 - 0.00099 19.0 0.0 0.006 16.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Thiolase_N PF00108.23 CRG82770.1 - 0.0021 17.5 0.1 0.0046 16.3 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 CRG82770.1 - 0.13 12.9 0.0 0.57 10.9 0.0 2.2 1 0 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 CRG82770.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG82771.1 - 6.3e-38 130.4 0.0 2.1e-37 128.7 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG82771.1 - 2.9e-22 78.9 0.0 5.1e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CRG82771.1 - 4.5e-12 46.0 0.0 6.8e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG82771.1 - 3.7e-10 40.0 0.0 8.3e-10 38.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG82771.1 - 1.2e-05 26.1 0.0 3.5e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 CRG82771.1 - 2e-05 23.7 0.0 3.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG82771.1 - 0.013 15.4 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding NmrA PF05368.13 CRG82771.1 - 0.019 14.6 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family adh_short PF00106.25 CRG82771.1 - 0.026 14.0 0.1 0.11 11.9 0.1 2.0 1 1 0 1 1 1 0 short chain dehydrogenase Beta-lactamase PF00144.24 CRG82772.1 - 1.7e-38 132.7 0.1 2.5e-38 132.2 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Fungal_trans_2 PF11951.8 CRG82773.1 - 1.4e-10 40.5 0.2 2.1e-10 40.0 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG82773.1 - 4.9e-05 23.4 6.4 7.8e-05 22.7 6.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short_C2 PF13561.6 CRG82778.1 - 3.6e-09 36.5 0.1 1.3e-08 34.7 0.1 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG82778.1 - 1.6e-05 24.4 0.1 2.2e-05 24.0 0.1 1.3 1 1 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 CRG82779.1 - 2.1e-08 34.3 0.1 8e-06 25.9 0.0 2.2 1 1 0 2 2 2 2 NAD(P)H-binding Epimerase PF01370.21 CRG82779.1 - 1.1e-07 31.5 0.2 3.8e-06 26.6 0.2 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG82779.1 - 3.6e-06 26.7 0.2 7.7e-06 25.6 0.2 1.6 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 CRG82779.1 - 4.3e-06 25.9 0.3 7.5e-06 25.2 0.1 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG82779.1 - 0.00064 19.0 0.0 0.0026 17.0 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG82779.1 - 0.0009 18.7 0.1 0.0013 18.2 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 CRG82779.1 - 0.0023 18.2 0.5 0.004 17.4 0.2 1.5 2 0 0 2 2 2 1 TrkA-N domain Polysacc_synt_2 PF02719.15 CRG82779.1 - 0.032 13.4 0.6 0.064 12.4 0.1 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CRG82779.1 - 0.041 13.0 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain PIG-L PF02585.17 CRG82779.1 - 0.13 12.9 0.0 0.46 11.1 0.0 1.9 2 0 0 2 2 2 0 GlcNAc-PI de-N-acetylase FMN_dh PF01070.18 CRG82780.1 - 1.5e-111 372.8 0.9 1.8e-111 372.5 0.9 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG82780.1 - 9.8e-22 76.9 0.1 3.9e-21 75.0 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CRG82780.1 - 1.5e-06 27.6 0.1 2.4e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG82780.1 - 1e-05 24.7 0.3 2.3e-05 23.6 0.3 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CRG82780.1 - 5.4e-05 22.7 0.5 7.4e-05 22.3 0.5 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 CRG82780.1 - 0.032 13.7 0.1 0.12 11.8 0.0 1.8 2 0 0 2 2 2 0 Histidine biosynthesis protein ThiG PF05690.14 CRG82780.1 - 0.045 13.1 0.1 1.5 8.0 0.0 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG ApbA PF02558.16 CRG82781.1 - 1.3e-31 109.3 0.1 1.7e-31 108.9 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CRG82781.1 - 4.6e-28 97.9 0.0 7.6e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Sacchrp_dh_NADP PF03435.18 CRG82781.1 - 0.082 13.2 0.0 0.19 12.0 0.0 1.6 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GFA PF04828.14 CRG82782.1 - 1.7e-24 85.9 0.0 2.5e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 CRG82782.1 - 0.12 12.4 3.3 0.84 9.7 0.2 2.4 2 1 0 2 2 2 0 Double zinc ribbon XhlA PF10779.9 CRG82783.1 - 0.063 13.5 0.1 0.17 12.1 0.1 1.7 1 0 0 1 1 1 0 Haemolysin XhlA COesterase PF00135.28 CRG82784.1 - 9.5e-66 222.7 0.0 1.7e-65 221.9 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG82784.1 - 0.00038 20.4 0.0 0.005 16.7 0.0 2.3 2 0 0 2 2 2 1 alpha/beta hydrolase fold MFS_1 PF07690.16 CRG82785.1 - 3.6e-40 138.0 34.6 7e-40 137.0 34.6 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG82785.1 - 7.1e-08 31.7 26.0 9.2e-07 28.1 14.5 3.3 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 CRG82785.1 - 1.3e-05 23.8 2.3 1.3e-05 23.8 2.3 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector MFS_1_like PF12832.7 CRG82785.1 - 0.0016 17.4 5.4 0.0016 17.4 5.4 2.3 2 1 0 2 2 2 1 MFS_1 like family OATP PF03137.20 CRG82785.1 - 0.0028 16.0 7.2 0.36 9.0 7.1 2.3 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family PglL_A PF15864.5 CRG82785.1 - 0.09 12.5 0.1 0.09 12.5 0.1 3.9 4 0 0 4 4 4 0 Protein glycosylation ligase Sulfatase PF00884.23 CRG82786.1 - 2.1e-60 204.7 1.5 6.6e-60 203.1 1.3 1.8 2 0 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 CRG82786.1 - 0.0083 16.4 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 CRG82786.1 - 0.01 15.5 2.5 0.44 10.1 0.5 2.2 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DAO PF01266.24 CRG82787.1 - 2.2e-39 136.0 0.1 2.6e-39 135.8 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG82787.1 - 0.00058 20.0 0.5 0.005 17.0 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG82787.1 - 0.00077 19.5 0.1 0.0028 17.7 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CRG82787.1 - 0.014 14.6 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 CRG82787.1 - 0.025 13.6 0.0 0.038 13.0 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG82787.1 - 0.042 13.1 0.1 0.87 8.8 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG82787.1 - 0.067 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF3433 PF11915.8 CRG82788.1 - 1.6e-31 108.6 15.8 4.2e-25 88.0 5.6 3.3 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) Sugar_tr PF00083.24 CRG82791.1 - 8e-76 255.7 9.2 1.1e-75 255.3 9.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG82791.1 - 6.6e-18 64.7 15.0 6.6e-18 64.7 15.0 2.3 3 0 0 3 3 3 1 Major Facilitator Superfamily G-patch PF01585.23 CRG82791.1 - 3.1e-11 43.0 1.1 3.1e-11 43.0 1.1 1.9 2 0 0 2 2 2 1 G-patch domain zf-RanBP PF00641.18 CRG82791.1 - 6.1e-10 38.2 3.6 1.1e-09 37.4 3.6 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 CRG82791.1 - 1.4e-05 24.8 0.1 0.00036 20.3 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 CRG82791.1 - 2.4e-05 24.3 1.9 8.3e-05 22.6 1.9 1.9 1 0 0 1 1 1 1 G-patch domain NCD3G PF07562.14 CRG82791.1 - 1.6 8.8 7.1 1.8 8.6 2.6 2.3 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Alpha-amylase PF00128.24 CRG82792.1 - 3.5e-113 378.6 3.7 5.4e-113 378.0 3.7 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 CRG82792.1 - 8.1e-08 32.3 0.0 1.7e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 CRG82792.1 - 0.0069 15.5 0.0 0.011 14.9 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain Fringe PF02434.16 CRG82793.1 - 8.5e-05 22.1 0.1 0.0014 18.1 0.1 2.2 1 1 0 1 1 1 1 Fringe-like PAN_1 PF00024.26 CRG82793.1 - 0.0039 17.1 0.0 0.0092 15.9 0.0 1.5 1 0 0 1 1 1 1 PAN domain PAN_4 PF14295.6 CRG82793.1 - 0.0067 16.3 0.3 0.013 15.4 0.3 1.5 1 0 0 1 1 1 1 PAN domain Glyco_transf_34 PF05637.12 CRG82793.1 - 0.079 12.7 1.9 0.15 11.7 1.9 1.4 1 0 0 1 1 1 0 galactosyl transferase GMA12/MNN10 family DFP PF04127.15 CRG82794.1 - 1.2e-14 54.5 0.0 2.1e-06 27.7 0.0 3.2 3 0 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein Atg29_N PF18388.1 CRG82795.1 - 1.5e-25 88.7 2.0 2.6e-25 88.0 2.0 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain Ebola_NP PF05505.12 CRG82795.1 - 0.46 8.7 5.0 0.59 8.4 5.0 1.2 1 0 0 1 1 1 0 Ebola nucleoprotein Porphyrn_cat_1 PF18206.1 CRG82796.1 - 5.8 7.6 6.7 0.88 10.2 1.8 2.0 2 0 0 2 2 2 0 Porphyranase catalytic subdomain 1 CENP-O PF09496.10 CRG82797.1 - 1.2e-66 224.8 0.2 2.6e-66 223.7 0.0 1.7 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component Pkinase PF00069.25 CRG82797.1 - 9.3e-20 71.1 0.0 1.2e-18 67.4 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG82797.1 - 1.4e-05 24.6 0.1 0.00081 18.7 0.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase TMF_TATA_bd PF12325.8 CRG82797.1 - 0.0025 18.0 1.4 0.0025 18.0 1.4 2.3 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 CRG82797.1 - 0.031 13.6 0.9 0.056 12.7 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4472 PF14739.6 CRG82797.1 - 0.086 13.6 1.5 0.26 12.0 1.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) TBK1_CCD1 PF18394.1 CRG82797.1 - 0.09 12.3 1.8 0.16 11.5 1.8 1.3 1 0 0 1 1 1 0 TANK-binding kinase 1 coiled-coil domain 1 DUF2205 PF10224.9 CRG82797.1 - 3.5 7.7 7.1 4 7.5 1.6 3.2 4 0 0 4 4 4 0 Short coiled-coil protein Cep57_CLD PF14073.6 CRG82797.1 - 4.8 7.2 6.3 0.53 10.3 1.6 1.8 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Catalase PF00199.19 CRG82798.1 - 5.2e-128 427.4 0.1 7.7e-128 426.8 0.1 1.2 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CRG82798.1 - 3.2e-08 33.7 0.0 3.4e-07 30.4 0.0 2.3 2 0 0 2 2 2 1 Catalase-related immune-responsive Amino_oxidase PF01593.24 CRG82799.1 - 2e-32 113.1 0.0 3.5e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pkinase PF00069.25 CRG82799.1 - 4e-24 85.4 0.0 3.4e-23 82.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG82799.1 - 3.7e-10 39.5 0.0 7e-06 25.5 0.0 2.4 3 0 0 3 3 3 2 Protein tyrosine kinase NAD_binding_8 PF13450.6 CRG82799.1 - 4.8e-09 36.3 0.0 1.1e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Acatn PF13000.7 CRG82800.1 - 5.2e-165 550.1 17.6 4.9e-85 286.1 6.7 3.1 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 MFS_1_like PF12832.7 CRG82800.1 - 0.036 12.9 10.1 0.063 12.1 10.0 1.5 1 1 0 1 1 1 0 MFS_1 like family TauD PF02668.16 CRG82801.1 - 4.6e-33 115.2 0.3 6.8e-33 114.6 0.3 1.3 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TilS PF09179.11 CRG82801.1 - 0.014 15.9 0.3 0.096 13.2 0.2 2.4 3 0 0 3 3 3 0 TilS substrate binding domain Yae1_N PF09811.9 CRG82802.1 - 6.7e-12 44.9 0.7 1.1e-11 44.2 0.7 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal PAPS_reduct PF01507.19 CRG82802.1 - 0.18 11.8 0.4 0.27 11.3 0.4 1.2 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Fungal_trans PF04082.18 CRG82806.1 - 4.6e-21 75.0 0.1 1.1e-20 73.8 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain ADH_N PF08240.12 CRG82807.1 - 2.9e-30 104.4 1.1 5.5e-30 103.5 1.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG82807.1 - 3.1e-23 82.2 0.1 5.3e-23 81.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG82807.1 - 1.1e-13 51.1 0.0 1.7e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CRG82807.1 - 9.2e-05 21.8 1.4 0.00018 20.9 1.4 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG82807.1 - 0.00033 21.7 0.0 0.00097 20.2 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 CRG82807.1 - 0.0074 15.5 0.6 0.016 14.4 0.6 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 CRG82807.1 - 0.011 15.3 0.1 0.018 14.6 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 CRG82807.1 - 0.026 13.9 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 CRG82807.1 - 0.15 12.2 0.5 0.27 11.3 0.5 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Sugar_tr PF00083.24 CRG82808.1 - 1.3e-96 324.3 22.2 1.5e-96 324.0 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG82808.1 - 3.5e-30 105.1 44.9 1.9e-26 92.8 23.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Folate_carrier PF01770.18 CRG82808.1 - 0.029 13.1 0.1 0.055 12.2 0.1 1.4 1 0 0 1 1 1 0 Reduced folate carrier SCO1-SenC PF02630.14 CRG82809.1 - 1.4e-48 164.2 0.1 2.7e-48 163.3 0.1 1.5 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 CRG82809.1 - 7.9e-05 22.6 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family DUF1180 PF06679.12 CRG82809.1 - 0.007 16.8 2.1 0.0098 16.3 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) Thioredoxin_8 PF13905.6 CRG82809.1 - 0.035 14.4 0.0 0.091 13.1 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like MoaE PF02391.17 CRG82810.1 - 3.9e-35 120.6 0.0 4.8e-35 120.2 0.0 1.1 1 0 0 1 1 1 1 MoaE protein DEAD PF00270.29 CRG82811.1 - 3.5e-42 144.2 0.0 5.3e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG82811.1 - 1.7e-26 92.8 0.0 3.9e-26 91.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Polysacc_deac_1 PF01522.21 CRG82811.1 - 2.5e-19 69.4 0.0 1.1e-18 67.3 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 CRG82811.1 - 0.083 12.5 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) ResIII PF04851.15 CRG82811.1 - 0.09 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit CMS1 PF14617.6 CRG82811.1 - 0.098 12.0 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Glyoxal_oxid_N PF07250.11 CRG82812.1 - 1.5e-38 132.4 0.0 4.4e-38 130.8 0.0 1.9 1 1 0 1 1 1 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 CRG82812.1 - 5.9e-22 77.8 0.0 1.4e-21 76.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) RCC1_2 PF13540.6 CRG82812.1 - 0.0069 16.2 0.1 0.13 12.1 0.0 3.0 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Fumble PF03630.14 CRG82813.1 - 2.7e-135 450.8 0.0 3.3e-135 450.5 0.0 1.0 1 0 0 1 1 1 1 Fumble Pyrophosphatase PF00719.19 CRG82814.1 - 0.049 13.4 0.0 0.098 12.5 0.0 1.4 1 0 0 1 1 1 0 Inorganic pyrophosphatase MCM_bind PF09739.9 CRG82814.1 - 3.9 5.8 6.1 5.4 5.3 6.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Hid1 PF12722.7 CRG82814.1 - 9.6 4.2 5.8 12 3.9 5.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GPI2 PF06432.11 CRG82815.1 - 3.1e-121 404.1 7.6 4.3e-121 403.7 7.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Glyco_hydro_18 PF00704.28 CRG82815.1 - 1.7e-19 70.7 5.8 7.2e-11 42.4 0.2 2.7 2 1 1 3 3 3 2 Glycosyl hydrolases family 18 Gln-synt_C PF00120.24 CRG82816.1 - 1.1e-58 199.0 0.0 3.4e-58 197.3 0.0 1.8 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 CRG82816.1 - 6e-16 59.1 0.0 1e-15 58.3 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase GCS2 PF04107.13 CRG82816.1 - 0.036 13.4 0.1 2.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Glutamate-cysteine ligase family 2(GCS2) HTH_43 PF09904.9 CRG82816.1 - 0.092 12.7 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn helix Glyco_hydro_18 PF00704.28 CRG82817.1 - 7.2e-64 216.5 1.1 8.3e-64 216.3 1.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Chitin_bind_1 PF00187.19 CRG82817.1 - 2e-11 44.2 18.4 4.8e-11 42.9 18.4 1.7 1 0 0 1 1 1 1 Chitin recognition protein Aldedh PF00171.22 CRG82818.1 - 5.1e-154 513.2 0.7 5.7e-154 513.0 0.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DotD PF16816.5 CRG82818.1 - 0.045 13.7 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 DotD protein Fungal_trans_2 PF11951.8 CRG82819.1 - 4.5e-10 38.9 0.1 6.6e-10 38.3 0.1 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG82820.1 - 8.2e-44 150.0 29.0 2e-36 125.7 25.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG82820.1 - 1e-12 47.4 12.9 8.1e-07 27.9 1.3 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein DUF4234 PF14018.6 CRG82820.1 - 0.044 13.9 1.2 19 5.4 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4234) OATP PF03137.20 CRG82820.1 - 0.074 11.3 7.6 0.074 11.3 1.3 3.0 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 CRG82820.1 - 0.19 10.5 18.4 2.3 7.0 8.8 3.7 2 2 1 3 3 3 0 MFS_1 like family ATG22 PF11700.8 CRG82820.1 - 3.2 6.3 9.0 0.36 9.4 0.1 2.8 3 1 0 3 3 3 0 Vacuole effluxer Atg22 like polyprenyl_synt PF00348.17 CRG82821.1 - 2.9e-44 151.0 0.0 4.5e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 CRG82821.1 - 0.00021 20.8 0.0 0.51 9.6 0.0 2.3 2 0 0 2 2 2 2 Terpene synthase family, metal binding domain ABC_tran PF00005.27 CRG82822.1 - 1.8e-16 60.9 0.5 3.2e-11 43.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 CRG82822.1 - 8.4e-12 44.9 14.5 1.7e-11 44.0 14.5 1.5 1 0 0 1 1 1 1 ABC-2 type transporter AAA_21 PF13304.6 CRG82822.1 - 0.001 19.0 0.2 0.0025 17.7 0.2 1.7 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system TMEM154 PF15102.6 CRG82822.1 - 0.008 16.1 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 TMEM154 protein family Gly-zipper_YMGG PF13441.6 CRG82822.1 - 1.3 8.8 5.8 0.28 11.0 1.3 2.1 2 0 0 2 2 2 0 YMGG-like Gly-zipper ABC2_membrane_3 PF12698.7 CRG82822.1 - 6.1 5.9 17.8 2.1 7.4 14.7 1.7 2 0 0 2 2 2 0 ABC-2 family transporter protein HicA_toxin PF07927.12 CRG82823.1 - 4.7e-05 23.3 0.0 0.00015 21.7 0.0 1.9 2 0 0 2 2 2 1 HicA toxin of bacterial toxin-antitoxin, MFS_1 PF07690.16 CRG82824.1 - 1.6e-19 70.1 46.7 1.6e-19 70.1 46.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5472 PF17566.2 CRG82824.1 - 0.29 11.1 1.6 1.8 8.6 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5472) Fungal_trans PF04082.18 CRG82825.1 - 6.8e-06 25.3 0.4 2.2e-05 23.7 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain TRI12 PF06609.13 CRG82827.1 - 3.8e-34 118.1 32.7 3.8e-34 118.1 32.7 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CRG82827.1 - 1e-19 70.7 51.2 1e-19 70.7 51.2 4.7 4 1 0 4 4 4 2 Major Facilitator Superfamily Erf4 PF10256.9 CRG82828.1 - 0.15 12.1 0.0 0.57 10.3 0.0 1.9 2 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Bul1_N PF04425.12 CRG82828.1 - 0.35 9.6 1.9 0.42 9.3 1.9 1.1 1 0 0 1 1 1 0 Bul1 N terminus HATPase_c PF02518.26 CRG82830.1 - 3.3e-22 79.1 0.1 8.8e-22 77.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG82830.1 - 4e-20 72.1 0.0 7e-20 71.3 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CRG82830.1 - 9.6e-13 48.0 0.1 6.4e-12 45.3 0.0 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain MFS_1 PF07690.16 CRG82831.1 - 1.1e-31 110.1 25.0 1.1e-31 110.0 19.8 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG82831.1 - 1.2e-08 34.3 9.7 1.2e-08 34.3 9.7 2.9 2 2 1 3 3 3 1 Sugar (and other) transporter SPC12 PF06645.13 CRG82831.1 - 0.6 10.2 6.8 2.8 8.1 0.2 3.9 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) UPF0016 PF01169.19 CRG82832.1 - 1.8e-39 133.9 27.7 3e-20 72.3 7.6 2.3 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 DUF2070 PF09843.9 CRG82832.1 - 0.0057 15.0 2.0 0.01 14.1 2.0 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) YIEGIA PF14045.6 CRG82832.1 - 0.14 11.0 0.2 0.23 10.3 0.2 1.2 1 0 0 1 1 1 0 YIEGIA protein G3P_acyltransf PF02660.15 CRG82832.1 - 7.7 6.6 14.9 10 6.2 6.5 2.3 2 0 0 2 2 2 0 Glycerol-3-phosphate acyltransferase Myb_DNA-binding PF00249.31 CRG82833.1 - 2.1e-08 34.2 0.1 4.5e-08 33.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain TRF PF08558.10 CRG82833.1 - 0.0012 18.5 1.1 0.0036 17.0 0.2 2.3 2 1 0 2 2 2 1 Telomere repeat binding factor (TRF) Myb_DNA-bind_6 PF13921.6 CRG82833.1 - 0.021 15.1 0.1 0.068 13.4 0.1 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain HTH_IclR PF09339.10 CRG82833.1 - 0.083 12.7 0.2 0.26 11.1 0.2 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain FlgN PF05130.12 CRG82833.1 - 2.4 8.7 7.2 1.1 9.8 3.5 2.3 2 0 0 2 2 2 0 FlgN protein Lipase_GDSL_2 PF13472.6 CRG82834.1 - 8.6e-15 55.6 0.0 1.1e-14 55.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG82834.1 - 2.2e-06 27.8 0.0 7.6e-06 26.0 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase GPI-anchored PF10342.9 CRG82835.1 - 5.4e-05 23.9 0.8 5.4e-05 23.9 0.8 3.2 1 1 2 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Peptidase_M20 PF01546.28 CRG82836.1 - 3.7e-32 111.7 0.0 1.4e-31 109.9 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG82836.1 - 4e-07 29.9 0.1 7.3e-07 29.1 0.1 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Lactamase_B PF00753.27 CRG82837.1 - 2.6e-09 37.4 0.2 4e-09 36.8 0.2 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG82837.1 - 1.5e-05 24.6 0.0 3.1e-05 23.6 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain FAD_binding_4 PF01565.23 CRG82838.1 - 3.7e-16 59.1 0.4 7.1e-16 58.2 0.4 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG82838.1 - 2.6e-10 40.2 0.1 1.2e-09 38.1 0.1 2.2 2 0 0 2 2 2 1 Berberine and berberine like Asp PF00026.23 CRG82839.1 - 2.4e-33 115.9 0.0 6.2e-33 114.5 0.0 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CRG82839.1 - 0.028 15.1 0.1 5.1 7.8 0.0 3.1 3 0 0 3 3 3 0 Aspartyl protease TAXi_N PF14543.6 CRG82839.1 - 0.11 12.8 5.4 2.4 8.4 3.4 3.3 3 1 0 3 3 3 0 Xylanase inhibitor N-terminal TnpW PF14202.6 CRG82839.1 - 0.22 11.4 0.3 0.46 10.3 0.3 1.5 1 0 0 1 1 1 0 Transposon-encoded protein TnpW MFS_1 PF07690.16 CRG82840.1 - 3.1e-40 138.2 51.7 1.2e-29 103.3 31.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG82840.1 - 3.9e-07 29.3 30.2 1.8e-06 27.1 7.9 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter Ada_Zn_binding PF02805.16 CRG82841.1 - 1.4e-29 101.9 2.6 2.3e-29 101.2 2.6 1.3 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 CRG82841.1 - 1.7e-08 34.4 0.0 3.7e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CRG82841.1 - 0.0047 17.2 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.6 CRG82841.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_3 PF01381.22 CRG82841.1 - 0.16 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix DOPA_dioxygen PF08883.11 CRG82842.1 - 1.1e-41 141.3 0.0 2.2e-41 140.4 0.0 1.5 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family Annexin PF00191.20 CRG82842.1 - 9.2e-14 51.3 1.1 0.0036 17.3 0.0 4.6 4 0 0 4 4 4 4 Annexin Peptidase_S28 PF05577.12 CRG82843.1 - 1.8e-47 162.1 1.1 4e-47 161.0 1.1 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase S28 APH PF01636.23 CRG82844.1 - 1.1e-13 51.7 0.2 7.1e-09 35.9 0.2 2.0 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG82844.1 - 3.7e-06 26.7 0.0 5.8e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF4049 PF13258.6 CRG82844.1 - 0.0017 17.5 0.0 0.0023 17.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4049) Pkinase PF00069.25 CRG82844.1 - 0.031 13.7 0.0 0.08 12.3 0.0 1.9 1 1 0 1 1 1 0 Protein kinase domain Septin PF00735.18 CRG82845.1 - 1.5e-33 116.3 0.5 1.5e-11 44.1 0.0 3.6 4 0 0 4 4 4 3 Septin FtsK_SpoIIIE PF01580.18 CRG82845.1 - 0.0007 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CRG82845.1 - 0.003 17.6 0.0 0.0054 16.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 CRG82845.1 - 0.016 14.9 0.4 0.2 11.3 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 CRG82845.1 - 0.03 14.4 0.2 0.11 12.6 0.1 2.2 1 1 0 1 1 1 0 Dynamin family G-alpha PF00503.20 CRG82845.1 - 0.04 13.1 0.0 0.13 11.4 0.0 1.7 1 1 0 1 1 1 0 G-protein alpha subunit DUF4142 PF13628.6 CRG82845.1 - 0.067 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) AAA_16 PF13191.6 CRG82845.1 - 0.088 13.2 0.0 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Vps62 PF06101.11 CRG82846.1 - 2.1e-11 42.8 4.4 1.9e-10 39.7 2.3 2.1 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 62 Baculo_PEP_C PF04513.12 CRG82848.1 - 0.0011 19.0 3.0 0.012 15.6 1.5 2.3 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran_CTD PF16326.5 CRG82848.1 - 0.016 15.5 1.2 0.016 15.5 1.2 4.4 3 1 2 5 5 4 0 ABC transporter C-terminal domain CENP-F_leu_zip PF10473.9 CRG82848.1 - 0.025 14.6 14.2 0.24 11.4 1.5 2.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Kre28 PF17097.5 CRG82848.1 - 0.047 12.6 3.3 0.092 11.7 3.2 1.8 1 1 0 1 1 1 0 Spindle pole body component LAP2alpha PF11560.8 CRG82848.1 - 0.055 12.9 0.1 0.39 10.1 0.0 2.3 2 1 1 3 3 3 0 Lamina-associated polypeptide 2 alpha AAA_13 PF13166.6 CRG82848.1 - 0.058 12.0 5.6 0.076 11.7 5.6 1.1 1 0 0 1 1 1 0 AAA domain Alpha-2-MRAP_C PF06401.11 CRG82848.1 - 0.061 13.3 3.8 5 7.0 1.1 2.7 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain COG2 PF06148.11 CRG82848.1 - 0.063 13.4 8.2 0.75 9.9 0.6 2.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Med9 PF07544.13 CRG82848.1 - 0.15 12.2 3.0 0.2 11.8 0.3 2.7 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Prefoldin PF02996.17 CRG82848.1 - 0.15 12.0 9.3 0.3 11.0 2.3 3.3 2 1 1 3 3 3 0 Prefoldin subunit DUF3552 PF12072.8 CRG82848.1 - 0.18 11.2 15.0 1 8.7 3.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Fez1 PF06818.15 CRG82848.1 - 0.27 11.7 16.4 0.73 10.2 5.0 2.2 1 1 1 2 2 2 0 Fez1 CEP63 PF17045.5 CRG82848.1 - 0.31 10.9 15.1 0.28 11.1 2.3 2.5 3 0 0 3 3 3 0 Centrosomal protein of 63 kDa BLOC1_2 PF10046.9 CRG82848.1 - 0.4 11.0 8.9 0.2 12.0 4.1 2.7 2 1 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 CRG82848.1 - 0.64 10.3 5.8 0.24 11.7 2.2 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 CRG82848.1 - 0.68 8.7 16.2 0.56 9.0 5.0 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 CRG82848.1 - 0.85 9.8 13.5 1.5 9.0 12.3 2.0 1 1 0 1 1 1 0 Tropomyosin like DUF2721 PF11026.8 CRG82848.1 - 0.89 9.4 4.5 1.5 8.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Cnn_1N PF07989.11 CRG82848.1 - 1.1 9.4 13.1 0.22 11.7 2.2 3.7 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 Jnk-SapK_ap_N PF09744.9 CRG82848.1 - 1.3 9.2 13.3 0.43 10.8 3.6 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 CRG82848.1 - 1.4 8.9 5.1 1.4 8.9 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Cob_adeno_trans PF01923.18 CRG82848.1 - 1.9 8.6 6.2 3.8 7.6 1.6 2.5 1 1 1 2 2 2 0 Cobalamin adenosyltransferase BST2 PF16716.5 CRG82848.1 - 2.9 8.5 14.5 8.9 7.0 1.7 2.6 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 FlaC_arch PF05377.11 CRG82848.1 - 3.1 8.3 7.6 37 4.8 1.6 3.4 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) MscS_porin PF12795.7 CRG82848.1 - 3.3 7.2 24.3 0.48 9.9 19.8 2.0 2 1 0 2 2 1 0 Mechanosensitive ion channel porin domain TMPIT PF07851.13 CRG82848.1 - 5.1 6.2 5.7 7.4 5.7 2.5 2.4 1 1 2 3 3 3 0 TMPIT-like protein SlyX PF04102.12 CRG82848.1 - 6.2 7.5 14.2 7.3 7.3 2.4 3.7 2 1 1 3 3 3 0 SlyX APG6_N PF17675.1 CRG82848.1 - 9.5 6.8 17.0 2.2 8.8 7.1 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region S4 PF01479.25 CRG82849.1 - 1.1e-12 47.4 0.8 1.1e-12 47.4 0.8 2.4 3 0 0 3 3 3 1 S4 domain Ribosomal_L21e PF01157.18 CRG82850.1 - 6.1e-46 154.4 2.9 1e-45 153.7 2.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L21e Mito_carr PF00153.27 CRG82851.1 - 1.4e-72 239.7 1.4 2.1e-24 85.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3455 PF11937.8 CRG82852.1 - 2.2e-37 128.9 0.5 2.8e-37 128.6 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) p450 PF00067.22 CRG82853.1 - 4.5e-70 236.7 0.0 6.8e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Peptidase_M26_C PF07580.14 CRG82853.1 - 0.086 11.3 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 M26 IgA1-specific Metallo-endopeptidase C-terminal region Methyltransf_25 PF13649.6 CRG82854.1 - 7.3e-22 77.9 0.0 1.4e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG82854.1 - 1.4e-21 76.9 0.0 2.5e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG82854.1 - 5e-20 71.8 0.0 7e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG82854.1 - 8.6e-20 71.2 0.0 1.3e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG82854.1 - 2e-15 57.3 0.0 4e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG82854.1 - 1.5e-13 50.6 0.0 7e-13 48.4 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 CRG82854.1 - 2e-09 37.5 0.0 3.2e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CRG82854.1 - 4.4e-08 32.9 0.0 7.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltr_RsmB-F PF01189.17 CRG82854.1 - 1.6e-06 27.9 0.0 2.7e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F MetW PF07021.12 CRG82854.1 - 5.2e-06 26.2 0.0 7.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 CRG82854.1 - 7.8e-06 25.4 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Fibrillarin PF01269.17 CRG82854.1 - 0.00021 20.5 0.0 0.00035 19.7 0.0 1.3 1 0 0 1 1 1 1 Fibrillarin Methyltransf_24 PF13578.6 CRG82854.1 - 0.00066 20.7 0.0 0.0014 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 CRG82854.1 - 0.002 18.3 0.0 0.0031 17.6 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase ADH_zinc_N PF00107.26 CRG82854.1 - 0.0032 17.4 0.0 0.0065 16.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase PrmA PF06325.13 CRG82854.1 - 0.0033 16.9 0.0 0.0058 16.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CRG82854.1 - 0.0066 16.5 0.0 0.02 14.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain NodS PF05401.11 CRG82854.1 - 0.011 15.4 0.0 0.016 14.8 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) GCD14 PF08704.10 CRG82854.1 - 0.015 15.0 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_29 PF03141.16 CRG82854.1 - 0.018 13.6 0.0 0.025 13.1 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_9 PF08003.11 CRG82854.1 - 0.022 13.7 0.0 0.03 13.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_3 PF01596.17 CRG82854.1 - 0.15 11.2 0.0 0.36 10.0 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase Octopine_DH PF02317.17 CRG82855.1 - 6.8e-38 130.1 0.0 2.3e-37 128.4 0.0 1.8 2 0 0 2 2 2 1 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain NAD_Gly3P_dh_N PF01210.23 CRG82855.1 - 8.8e-09 35.5 0.0 1.8e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 CRG82855.1 - 3.3e-06 27.6 0.0 7.4e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_8 PF13450.6 CRG82855.1 - 0.00013 22.1 0.0 0.00032 20.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG82855.1 - 0.0026 17.0 0.0 0.0036 16.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG82855.1 - 0.0028 17.0 0.0 0.0034 16.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CRG82855.1 - 0.0046 15.7 0.0 0.0072 15.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein ApbA PF02558.16 CRG82855.1 - 0.0052 16.4 0.0 0.0085 15.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 CRG82855.1 - 0.033 13.8 0.0 0.062 12.9 0.0 1.6 1 1 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 CRG82855.1 - 0.068 12.5 0.0 0.13 11.6 0.0 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 CRG82855.1 - 0.093 12.0 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG82855.1 - 0.1 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG82855.1 - 0.12 11.4 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.22 CRG82855.1 - 0.14 11.2 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CRG82855.1 - 0.2 10.7 0.0 0.28 10.2 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain Ctr PF04145.15 CRG82856.1 - 2.6e-24 86.5 6.5 6.5e-24 85.2 6.5 1.6 1 1 0 1 1 1 1 Ctr copper transporter family Ferric_reduct PF01794.19 CRG82857.1 - 2.4e-20 72.9 19.3 2.4e-20 72.9 19.3 2.3 2 1 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG82857.1 - 2e-14 54.0 0.0 3.1e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG82857.1 - 3.9e-12 46.2 0.0 9.7e-12 44.9 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain DUF4405 PF14358.6 CRG82857.1 - 5.4 7.6 20.9 0.09 13.3 2.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Asp PF00026.23 CRG82858.1 - 1.2e-56 192.4 2.2 1.4e-56 192.2 2.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG82858.1 - 1.6e-11 44.7 1.1 1.7e-06 28.4 0.0 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG82858.1 - 0.0015 19.1 0.0 0.38 11.4 0.0 3.0 3 0 0 3 3 3 1 Aspartyl protease Glyco_hydro_43 PF04616.14 CRG82859.1 - 9.3e-37 126.9 0.1 1.1e-36 126.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 zf-H2C2_2 PF13465.6 CRG82860.1 - 0.0088 16.4 2.4 0.0088 16.4 2.4 3.8 4 0 0 4 4 4 1 Zinc-finger double domain Abhydrolase_3 PF07859.13 CRG82861.1 - 3.6e-21 76.0 0.0 7.2e-21 75.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG82861.1 - 1.2e-18 67.2 0.0 8.5e-14 51.2 0.0 2.2 2 0 0 2 2 2 2 Steryl acetyl hydrolase DUF4149 PF13664.6 CRG82861.1 - 2.4e-18 66.4 0.1 2.3e-17 63.2 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF2974 PF11187.8 CRG82861.1 - 0.0042 16.7 0.0 0.0071 15.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) MbeB_N PF04837.12 CRG82861.1 - 0.058 13.7 0.4 0.12 12.7 0.4 1.5 1 0 0 1 1 1 0 MbeB-like, N-term conserved region RRM_1 PF00076.22 CRG82862.1 - 0.00089 19.0 0.0 0.0017 18.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SecE PF00584.20 CRG82864.1 - 7.8e-15 54.5 0.1 9.3e-15 54.3 0.1 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex WD40 PF00400.32 CRG82865.1 - 1.3e-19 70.1 19.5 0.00058 20.6 0.3 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 CRG82865.1 - 8.7e-05 21.2 6.3 0.084 11.4 0.1 4.2 2 1 2 4 4 4 3 Cytochrome D1 heme domain ANAPC4_WD40 PF12894.7 CRG82865.1 - 0.0034 17.7 0.0 0.068 13.5 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 CRG82865.1 - 0.036 14.5 1.3 24 5.6 0.0 4.0 4 0 0 4 4 4 0 PQQ-like domain Glyoxal_oxid_N PF07250.11 CRG82865.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus PD40 PF07676.12 CRG82865.1 - 0.07 13.1 0.1 0.83 9.7 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat MCRA PF06100.11 CRG82866.1 - 3.7e-157 524.1 0.0 5.7e-157 523.5 0.0 1.2 1 0 0 1 1 1 1 MCRA family Ank_2 PF12796.7 CRG82866.1 - 4.2e-24 84.9 10.4 2e-10 41.1 0.2 4.2 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG82866.1 - 4e-17 62.3 1.5 0.0001 22.8 0.1 5.9 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG82866.1 - 8.4e-12 44.2 2.7 2.6 8.9 0.0 8.0 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 CRG82866.1 - 5.9e-09 36.0 9.5 0.0029 18.0 0.0 6.8 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 CRG82866.1 - 1.5e-06 28.3 9.2 0.35 11.3 0.8 5.6 3 1 2 5 5 5 3 Ankyrin repeats (many copies) NAD_binding_8 PF13450.6 CRG82866.1 - 5.8e-06 26.4 0.2 1.9e-05 24.8 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain AI-2E_transport PF01594.16 CRG82866.1 - 2.2 7.3 11.2 0.04 13.1 0.8 2.6 3 0 0 3 3 3 0 AI-2E family transporter Lipase_3 PF01764.25 CRG82867.1 - 4.5e-32 110.9 0.0 6.9e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 CRG82867.1 - 0.0093 16.0 0.1 0.022 14.8 0.1 1.6 1 0 0 1 1 1 1 Lipase 3 N-terminal region DUF2974 PF11187.8 CRG82867.1 - 0.014 15.0 0.0 0.045 13.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 CRG82867.1 - 0.023 15.3 0.0 0.044 14.4 0.0 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG82867.1 - 0.059 12.6 0.0 0.091 12.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Aldo_ket_red PF00248.21 CRG82868.1 - 2e-45 155.2 0.0 2.4e-45 155.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_15 PF00723.21 CRG82871.1 - 1.6e-51 175.5 0.0 1.6e-49 168.9 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 HSP20 PF00011.21 CRG82872.1 - 9.9e-19 67.4 0.0 2.6e-12 46.8 0.0 2.1 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CRG82872.1 - 7.4e-07 28.6 0.0 2.4e-06 27.0 0.0 1.8 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Fungal_trans PF04082.18 CRG82873.1 - 1.2e-16 60.6 0.4 2.3e-16 59.6 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG82873.1 - 8.9e-12 44.6 42.7 1.9e-07 30.3 8.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG82873.1 - 2.9e-08 33.0 3.6 4.9e-08 32.3 2.9 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter Zn_clus PF00172.18 CRG82873.1 - 2.8e-07 30.5 6.9 5.7e-07 29.6 6.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC92 PF14916.6 CRG82873.1 - 0.0087 15.8 0.6 0.02 14.7 0.6 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function Pkinase PF00069.25 CRG82874.1 - 3.9e-62 210.0 0.0 5.5e-62 209.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG82874.1 - 7e-28 97.6 0.0 1.1e-27 97.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.24 CRG82874.1 - 8.9e-26 90.1 0.2 1.9e-25 89.0 0.2 1.6 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.6 CRG82874.1 - 1.1e-05 24.9 0.0 2.8e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CRG82874.1 - 0.0003 20.5 0.0 0.4 10.3 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CRG82874.1 - 0.0013 18.7 0.0 0.072 13.0 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CRG82874.1 - 0.026 13.5 0.2 0.11 11.4 0.0 2.0 3 0 0 3 3 3 0 Haspin like kinase domain Kdo PF06293.14 CRG82874.1 - 0.097 12.0 0.1 0.3 10.4 0.1 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Myb_DNA-bind_6 PF13921.6 CRG82875.1 - 3.4e-16 59.2 0.0 3.6e-08 33.5 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG82875.1 - 2.3e-15 56.5 0.2 1.1e-07 31.9 0.1 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 CRG82875.1 - 0.004 17.2 0.0 2.5 8.2 0.0 2.5 2 1 0 2 2 2 2 SLIDE Nop16 PF09420.10 CRG82875.1 - 0.037 14.1 0.3 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 adh_short_C2 PF13561.6 CRG82877.1 - 9.4e-50 169.3 0.5 1.2e-49 169.0 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG82877.1 - 4.9e-41 140.3 0.9 6.3e-41 140.0 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG82877.1 - 1e-08 35.3 0.2 1.3e-08 34.9 0.2 1.2 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 CRG82877.1 - 0.0021 18.0 0.1 0.0033 17.3 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus CbiA PF01656.23 CRG82877.1 - 0.1 12.6 0.3 0.25 11.4 0.3 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain 2-Hacid_dh_C PF02826.19 CRG82877.1 - 0.12 11.8 1.1 0.25 10.7 0.6 1.7 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GST_N_3 PF13417.6 CRG82878.1 - 9.1e-15 54.8 0.0 1.7e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG82878.1 - 9.4e-14 51.5 0.0 4.2e-13 49.4 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG82878.1 - 1.3e-12 47.8 0.0 2.7e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG82878.1 - 2.3e-12 46.9 0.0 4.1e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG82878.1 - 9e-09 35.4 0.0 1.6e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG82878.1 - 2.1e-06 27.7 0.0 4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CRG82878.1 - 0.21 11.4 0.0 0.54 10.1 0.0 1.7 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain RasGEF PF00617.19 CRG82879.1 - 1.7e-07 31.6 0.0 4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain Ribosomal_S4e PF00900.20 CRG82880.1 - 2.2e-37 126.8 0.2 5.8e-37 125.5 0.2 1.7 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 CRG82880.1 - 3e-24 84.4 0.0 5.5e-24 83.5 0.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 CRG82880.1 - 2.5e-17 62.7 5.2 4.8e-17 61.8 5.2 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 CRG82880.1 - 4.5e-06 26.3 0.0 8.8e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 CRG82880.1 - 0.00015 21.6 2.9 0.00015 21.6 2.9 2.9 3 0 0 3 3 3 1 KOW motif Semialdhyde_dhC PF02774.18 CRG82881.1 - 1.8e-35 122.7 0.0 2.5e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 CRG82881.1 - 1.6e-27 96.3 0.0 3.1e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain FAD-oxidase_C PF02913.19 CRG82882.1 - 9.8e-63 212.1 0.0 1.4e-62 211.5 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CRG82882.1 - 4.4e-34 117.2 0.0 9e-34 116.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Cgr1 PF03879.14 CRG82882.1 - 0.32 11.4 2.1 3.3 8.1 0.1 2.3 2 0 0 2 2 2 0 Cgr1 family ATG16 PF08614.11 CRG82883.1 - 0.002 18.4 15.0 0.002 18.4 15.0 4.5 2 1 3 5 5 5 2 Autophagy protein 16 (ATG16) Spc7 PF08317.11 CRG82883.1 - 0.0037 16.2 67.9 0.01 14.7 27.9 3.3 1 1 2 3 3 3 2 Spc7 kinetochore protein APG6_N PF17675.1 CRG82883.1 - 0.0054 17.3 13.4 0.0054 17.3 13.4 4.6 1 1 3 4 4 4 1 Apg6 coiled-coil region HALZ PF02183.18 CRG82883.1 - 0.026 14.7 0.4 0.026 14.7 0.4 5.1 4 1 1 5 5 5 0 Homeobox associated leucine zipper Filament PF00038.21 CRG82883.1 - 0.95 9.0 66.4 0.066 12.8 14.6 3.6 1 1 2 3 3 3 0 Intermediate filament protein HK97-gp10_like PF04883.12 CRG82883.1 - 1.7 9.7 4.2 6.6 7.8 4.2 2.1 1 0 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component Rootletin PF15035.6 CRG82883.1 - 2.2 8.3 63.8 0.16 12.0 14.5 3.8 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion LPP PF04728.13 CRG82883.1 - 3.4 8.1 20.1 3.8 8.0 0.4 5.3 4 1 1 5 5 5 0 Lipoprotein leucine-zipper RdRP PF05183.12 CRG82884.1 - 2e-190 634.3 0.0 2.8e-190 633.9 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase ELP6 PF09807.9 CRG82884.1 - 2.1e-12 47.0 0.0 2.5e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 Elongation complex protein 6 RRM_1 PF00076.22 CRG82884.1 - 0.013 15.3 0.0 0.038 13.8 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Slu7 PF11708.8 CRG82885.1 - 2.2e-82 276.9 17.7 2.2e-82 276.9 17.7 2.0 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 CRG82885.1 - 0.03 14.1 0.6 0.071 12.9 0.6 1.6 1 0 0 1 1 1 0 Zinc knuckle Carn_acyltransf PF00755.20 CRG82886.1 - 1e-200 668.4 0.1 1.1e-200 668.2 0.1 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase ArabFuran-catal PF09206.11 CRG82887.1 - 5.6e-136 453.0 11.5 7.3e-136 452.6 11.5 1.1 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 CRG82887.1 - 3.4e-45 153.5 0.8 5.9e-45 152.7 0.8 1.4 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain DNA_pol_B PF00136.21 CRG82888.1 - 4.4e-105 352.0 0.0 7.9e-105 351.2 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CRG82888.1 - 1.3e-23 83.7 0.1 8.1e-14 51.5 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CRG82888.1 - 5.6e-16 58.8 10.5 5.6e-16 58.8 10.5 2.4 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta Sugar_tr PF00083.24 CRG82889.1 - 2.4e-115 386.0 20.7 3.6e-115 385.4 20.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter AAA_12 PF13087.6 CRG82889.1 - 1.9e-39 135.4 0.0 3.5e-39 134.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CRG82889.1 - 1.3e-25 90.7 1.2 1.6e-24 87.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain MFS_1 PF07690.16 CRG82889.1 - 5e-17 61.9 48.7 5.2e-10 38.8 15.9 2.3 1 1 0 2 2 2 2 Major Facilitator Superfamily AAA_19 PF13245.6 CRG82889.1 - 3.8e-09 37.0 0.0 1.5e-08 35.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CRG82889.1 - 4.1e-07 29.6 1.0 0.0015 17.9 0.0 2.6 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CRG82889.1 - 1.4e-05 24.9 0.1 0.0017 18.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF4768 PF15989.5 CRG82889.1 - 0.00041 20.2 0.2 0.15 12.1 0.0 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4768) ResIII PF04851.15 CRG82889.1 - 0.0042 17.1 0.0 0.012 15.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 CRG82889.1 - 0.034 13.9 1.0 0.91 9.2 0.0 3.1 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 CRG82889.1 - 0.071 12.2 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein IncE PF17627.2 CRG82889.1 - 0.21 11.6 4.4 6.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Inclusion membrane protein E Fungal_trans PF04082.18 CRG82890.1 - 4.6e-27 94.7 0.1 7.5e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG82890.1 - 4.1e-09 36.4 10.9 6.7e-09 35.7 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gal4_dimer PF03902.13 CRG82890.1 - 2.5e-05 24.3 0.0 4.9e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Gal4-like dimerisation domain Opy2 PF09463.10 CRG82890.1 - 2.7 8.4 6.9 5.7 7.4 6.9 1.5 1 0 0 1 1 1 0 Opy2 protein DJ-1_PfpI PF01965.24 CRG82891.1 - 5.9e-12 45.7 0.0 6.4e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family COX6A PF02046.15 CRG82892.1 - 2.3e-52 176.2 1.7 2.7e-52 176.0 1.7 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Exo_endo_phos PF03372.23 CRG82893.1 - 5.5e-14 52.2 0.0 8.6e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 CRG82893.1 - 1.2e-05 25.3 1.4 3.3e-05 23.9 1.4 1.8 1 1 0 1 1 1 1 GRF zinc finger MATalpha_HMGbox PF04769.12 CRG82895.1 - 3e-38 131.2 0.0 4.2e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Baculo_19 PF04798.12 CRG82895.1 - 0.0036 17.0 0.0 0.0059 16.3 0.0 1.3 1 0 0 1 1 1 1 Baculovirus 19 kDa protein conserved region ANTH PF07651.16 CRG82897.1 - 8.9e-71 238.1 0.0 8.9e-71 238.1 0.0 3.0 3 1 0 3 3 3 1 ANTH domain I_LWEQ PF01608.17 CRG82897.1 - 2.7e-56 190.0 8.0 2.7e-56 190.0 8.0 5.8 4 2 1 6 6 6 1 I/LWEQ domain TcdB_N PF12918.7 CRG82897.1 - 0.02 15.2 5.2 0.035 14.4 2.4 3.1 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain TAF8_C PF10406.9 CRG82897.1 - 1.1 9.9 3.7 3.1 8.4 2.4 2.7 1 1 0 1 1 1 0 Transcription factor TFIID complex subunit 8 C-term L27 PF02828.16 CRG82897.1 - 6.3 6.6 7.6 5.2 6.9 0.1 3.8 4 0 0 4 4 4 0 L27 domain MMM1 PF10296.9 CRG82898.1 - 1e-05 24.8 0.0 4.3e-05 22.7 0.0 2.0 1 1 1 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 CRG82898.1 - 0.0055 17.1 0.0 0.033 14.6 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 CRG82898.1 - 0.019 15.3 0.1 0.081 13.3 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain Endonuc_Holl PF10107.9 CRG82899.1 - 0.26 11.1 2.8 3.1 7.6 4.1 2.0 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Fzo_mitofusin PF04799.13 CRG82899.1 - 1.5 8.4 5.6 2.8 7.5 5.6 1.4 1 0 0 1 1 1 0 fzo-like conserved region Peptidase_S49_N PF08496.10 CRG82899.1 - 4.9 7.2 6.1 10 6.2 6.1 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PCI PF01399.27 CRG82900.1 - 3.6e-21 75.6 2.0 3.8e-21 75.6 0.5 1.9 2 0 0 2 2 2 1 PCI domain DUF5457 PF17540.2 CRG82900.1 - 0.038 14.1 0.1 0.26 11.4 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5457) TPR_7 PF13176.6 CRG82900.1 - 0.062 13.4 3.4 3.3 8.0 0.1 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 CRG82900.1 - 0.11 12.4 0.9 1.2 9.1 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 CRG82900.1 - 0.19 11.9 4.5 0.67 10.2 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat PriX PF18689.1 CRG82900.1 - 1.3 9.4 3.9 5.8 7.3 0.2 3.5 4 1 0 4 4 4 0 Primase X Peptidase_C65 PF10275.9 CRG82901.1 - 9.8e-60 202.0 0.0 1.6e-59 201.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase C65 Otubain Ank_2 PF12796.7 CRG82901.1 - 3.8e-21 75.5 8.1 7.7e-12 45.6 2.5 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG82901.1 - 1e-17 63.9 8.8 2.2e-07 31.0 0.1 4.7 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG82901.1 - 2.7e-15 56.5 5.1 1.1e-06 29.0 0.7 4.2 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 CRG82901.1 - 1e-14 54.2 8.2 0.0068 16.8 0.1 4.9 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 CRG82901.1 - 3.4e-13 48.5 3.5 0.019 15.4 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat ATP-grasp_4 PF13535.6 CRG82901.1 - 0.021 14.4 0.2 0.13 11.8 0.0 2.3 3 0 0 3 3 3 0 ATP-grasp domain BTB PF00651.31 CRG82903.1 - 0.00025 21.2 0.0 0.0055 16.9 0.0 2.6 3 0 0 3 3 3 1 BTB/POZ domain ACDC PF14733.6 CRG82903.1 - 0.082 13.2 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 AP2-coincident C-terminal MAJIN PF15077.6 CRG82903.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Peptidase_S15 PF02129.18 CRG82904.1 - 2.2e-32 112.7 0.3 5.3e-32 111.5 0.3 1.6 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 CRG82904.1 - 2.7e-20 73.3 1.4 1e-16 61.6 0.1 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Glyoxalase PF00903.25 CRG82904.1 - 6e-08 32.9 0.8 0.0024 18.0 0.2 3.1 3 0 0 3 3 3 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Kdo PF06293.14 CRG82904.1 - 0.00021 20.7 0.1 0.00036 20.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 CRG82904.1 - 0.002 17.5 0.1 0.0045 16.4 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain WaaY PF06176.11 CRG82904.1 - 0.042 13.5 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Choline_kinase PF01633.20 CRG82904.1 - 0.078 12.6 0.2 0.14 11.7 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Hydrolase_4 PF12146.8 CRG82904.1 - 0.12 11.6 0.0 0.3 10.3 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 FAD_binding_3 PF01494.19 CRG82905.1 - 4.1e-18 65.8 0.1 1.2e-17 64.2 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain ADC PF06314.11 CRG82905.1 - 1.6e-13 50.8 0.0 3.2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Acetoacetate decarboxylase (ADC) NAD_binding_8 PF13450.6 CRG82905.1 - 1.1e-05 25.6 0.4 2.4e-05 24.4 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG82905.1 - 3.2e-05 23.3 2.2 0.00031 20.1 2.2 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG82905.1 - 3.4e-05 23.1 0.4 5.5e-05 22.4 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG82905.1 - 0.00075 19.2 2.9 0.0037 16.9 1.7 2.0 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CRG82905.1 - 0.005 16.3 0.1 0.008 15.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CRG82905.1 - 0.023 14.0 0.2 0.44 9.8 0.0 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CRG82905.1 - 0.029 14.9 0.3 0.17 12.5 0.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG82905.1 - 0.029 13.1 0.4 0.029 13.1 0.4 1.9 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 CRG82905.1 - 0.041 13.0 0.7 0.068 12.2 0.7 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 CRG82905.1 - 0.075 11.9 1.0 0.14 10.9 0.6 1.6 1 1 0 1 1 1 0 Tryptophan halogenase DUF1344 PF07076.11 CRG82905.1 - 0.16 11.9 0.1 0.46 10.4 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) zf-C2H2 PF00096.26 CRG82906.1 - 5.6e-05 23.4 0.5 5.6e-05 23.4 0.5 2.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type Fungal_trans PF04082.18 CRG82906.1 - 5.7e-05 22.3 0.1 0.00011 21.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 CRG82906.1 - 0.017 15.9 0.3 0.017 15.9 0.3 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CRG82906.1 - 2.4 8.2 5.2 0.21 11.5 0.4 1.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Fungal_trans PF04082.18 CRG82907.1 - 0.0014 17.7 0.4 0.0033 16.5 0.4 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain CWC25 PF12542.8 CRG82908.1 - 2.6e-25 89.3 0.3 2.6e-25 89.3 0.3 4.2 2 2 1 3 3 3 1 Pre-mRNA splicing factor Cir_N PF10197.9 CRG82908.1 - 1.9e-12 47.2 7.9 1.9e-12 47.2 7.9 4.1 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR FA_desaturase PF00487.24 CRG82908.1 - 8.9 6.1 6.8 14 5.4 6.8 1.3 1 0 0 1 1 1 0 Fatty acid desaturase Ras PF00071.22 CRG82909.1 - 1.8e-51 173.9 0.0 2.1e-51 173.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG82909.1 - 4.1e-20 72.2 0.0 6.4e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG82909.1 - 7.3e-10 38.6 0.0 9.1e-10 38.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CRG82909.1 - 0.0015 18.0 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 CRG82909.1 - 0.072 12.2 0.0 0.092 11.9 0.0 1.3 1 1 0 1 1 1 0 G-protein alpha subunit BPL_LplA_LipB PF03099.19 CRG82910.1 - 9.1e-06 25.6 0.0 2e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Putative_PNPOx PF01243.20 CRG82911.1 - 1.4e-11 44.4 0.0 2.9e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 CRG82911.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.6 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase NIPSNAP PF07978.13 CRG82912.1 - 1.3e-40 137.7 0.7 1.2e-28 99.3 0.2 2.6 2 0 0 2 2 2 2 NIPSNAP Ribosomal_S27e PF01667.17 CRG82912.1 - 5.6e-27 93.2 6.7 9.4e-27 92.5 6.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S27 CDP-OH_P_transf PF01066.21 CRG82912.1 - 1.9e-16 60.6 0.1 1.9e-16 60.6 0.1 3.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase DUF3094 PF11293.8 CRG82912.1 - 0.21 11.3 0.8 0.63 9.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) FSH1 PF03959.13 CRG82914.1 - 5e-70 235.5 0.0 6.4e-70 235.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Thioesterase PF00975.20 CRG82914.1 - 0.01 16.0 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_2 PF02230.16 CRG82914.1 - 0.044 13.6 0.0 8.6 6.1 0.0 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CRG82914.1 - 0.17 11.1 0.0 0.6 9.3 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 PCI PF01399.27 CRG82915.1 - 5.2e-21 75.1 0.0 3.2e-20 72.6 0.0 2.3 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 CRG82915.1 - 5.6e-16 58.4 0.6 1.3e-15 57.2 0.6 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain TP_methylase PF00590.20 CRG82916.1 - 7e-49 166.7 0.0 3.6e-48 164.3 0.0 1.9 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_C PF14823.6 CRG82916.1 - 4.7e-11 42.2 0.0 2.1e-06 27.3 0.0 2.5 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 CRG82916.1 - 1.2e-09 38.5 0.0 2.3e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 CRG82916.1 - 4e-07 29.4 0.2 1.2e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central preATP-grasp_3 PF18301.1 CRG82916.1 - 0.13 12.6 0.1 0.73 10.2 0.0 2.3 2 0 0 2 2 2 0 pre ATP-grasp 3 domain SelK_SelG PF10961.8 CRG82917.1 - 0.012 16.2 0.0 0.012 16.2 0.0 3.0 2 1 0 2 2 2 0 Selenoprotein SelK_SelG DUF2967 PF11179.8 CRG82917.1 - 0.32 9.1 1.1 0.35 8.9 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DeoC PF01791.9 CRG82919.1 - 1.8e-16 60.5 5.2 2.5e-16 60.0 5.2 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase DHO_dh PF01180.21 CRG82919.1 - 3.3e-05 23.3 0.4 6e-05 22.4 0.4 1.5 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase His_biosynth PF00977.21 CRG82919.1 - 0.0057 16.1 0.6 0.011 15.2 0.1 1.8 2 0 0 2 2 2 1 Histidine biosynthesis protein Tma16 PF11176.8 CRG82919.1 - 0.21 11.5 0.0 0.35 10.7 0.0 1.3 1 0 0 1 1 1 0 Translation machinery-associated protein 16 WD40 PF00400.32 CRG82920.1 - 9.2e-10 39.0 3.2 4.8e-05 24.0 0.4 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG82920.1 - 0.00011 22.5 0.0 5.6 7.3 0.0 4.6 1 1 4 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain TMF_TATA_bd PF12325.8 CRG82920.1 - 0.003 17.8 3.4 0.0055 16.9 3.4 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding MMS1_N PF10433.9 CRG82920.1 - 0.016 13.9 0.0 0.056 12.1 0.0 1.8 1 1 1 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Swi5 PF07061.11 CRG82920.1 - 0.018 15.1 0.5 0.047 13.8 0.3 1.8 1 1 0 1 1 1 0 Swi5 Gryzun-like PF12742.7 CRG82920.1 - 0.044 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking SBBP PF06739.11 CRG82920.1 - 0.12 12.4 0.1 0.69 10.0 0.1 2.3 2 0 0 2 2 2 0 Beta-propeller repeat DUF4407 PF14362.6 CRG82920.1 - 4.9 6.4 15.0 7.5 5.8 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FMN_red PF03358.15 CRG82922.1 - 0.064 13.0 0.0 0.065 13.0 0.0 1.1 1 0 0 1 1 1 0 NADPH-dependent FMN reductase adh_short PF00106.25 CRG82923.1 - 3.6e-29 101.6 0.0 5.8e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG82923.1 - 4e-21 75.7 0.0 8.5e-21 74.6 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG82923.1 - 0.0055 16.6 0.0 0.084 12.8 0.0 2.1 2 0 0 2 2 2 1 KR domain LIAS_N PF16881.5 CRG82924.1 - 1e-24 87.0 0.0 2.1e-24 86.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 CRG82924.1 - 3.4e-14 53.6 0.0 5.4e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily HAD PF12710.7 CRG82925.1 - 8.6e-22 78.5 0.0 1.2e-21 78.0 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG82925.1 - 1.9e-17 64.3 0.2 2.6e-17 63.8 0.2 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CRG82925.1 - 2e-09 37.6 0.0 1.2e-08 35.0 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CRG82925.1 - 0.00017 21.7 0.0 0.0051 16.9 0.0 2.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 CRG82925.1 - 0.003 17.0 0.0 0.025 14.0 0.0 2.0 1 1 0 1 1 1 1 Putative Phosphatase DUF705 PF05152.12 CRG82925.1 - 0.12 11.8 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) S6PP PF05116.13 CRG82925.1 - 0.14 11.6 0.1 0.87 9.1 0.0 2.2 3 0 0 3 3 3 0 Sucrose-6F-phosphate phosphohydrolase Pneumo_M2 PF07380.11 CRG82926.1 - 0.11 12.8 0.3 0.25 11.6 0.1 1.8 2 0 0 2 2 2 0 Pneumovirus M2 protein PAPS_reduct PF01507.19 CRG82927.1 - 2.2e-45 154.8 0.1 7.4e-45 153.1 0.0 1.7 2 0 0 2 2 2 1 Phosphoadenosine phosphosulfate reductase family Troponin PF00992.20 CRG82927.1 - 0.13 12.6 0.0 0.13 12.6 0.0 1.6 2 0 0 2 2 2 0 Troponin ATP-sulfurylase PF01747.17 CRG82928.1 - 8.5e-88 293.3 0.0 1.2e-87 292.8 0.0 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 CRG82928.1 - 9.7e-61 204.3 0.0 1.5e-60 203.7 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 CRG82928.1 - 2.4e-51 173.5 0.0 4e-51 172.8 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain CPT PF07931.12 CRG82928.1 - 0.12 12.2 0.0 0.74 9.6 0.0 2.1 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Ribosomal_S21 PF01165.20 CRG82929.1 - 0.019 14.6 0.0 0.06 13.1 0.0 1.9 1 0 0 1 1 1 0 Ribosomal protein S21 DEAD PF00270.29 CRG82930.1 - 2.4e-37 128.4 0.0 3.4e-37 127.9 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG82930.1 - 1.7e-23 83.1 0.0 3.4e-22 78.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG82930.1 - 9e-06 25.8 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG82930.1 - 7e-05 22.2 0.0 0.0001 21.6 0.0 1.1 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_19 PF13245.6 CRG82930.1 - 0.0014 19.0 0.0 0.0033 17.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 CRG82930.1 - 0.031 13.8 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Methyltransf_11 PF08241.12 CRG82931.1 - 4.7e-17 62.4 0.0 9.3e-17 61.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG82931.1 - 1.3e-15 57.8 0.0 3.1e-15 56.7 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG82931.1 - 2.1e-12 47.2 0.0 2.8e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG82931.1 - 5.4e-10 39.9 0.0 1.1e-09 38.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG82931.1 - 1.9e-09 37.5 0.0 3.3e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG82931.1 - 4.4e-06 26.2 0.0 6.7e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CRG82931.1 - 0.00057 20.1 0.0 0.00082 19.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase DREV PF05219.12 CRG82931.1 - 0.00059 19.0 0.0 0.00082 18.5 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase MTS PF05175.14 CRG82931.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_16 PF10294.9 CRG82931.1 - 0.062 13.0 0.0 0.11 12.3 0.0 1.3 1 1 0 1 1 1 0 Lysine methyltransferase Methyltransf_8 PF05148.15 CRG82931.1 - 0.077 12.8 0.0 0.15 11.9 0.0 1.5 1 1 0 1 1 1 0 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.17 CRG82931.1 - 0.085 12.0 0.0 0.22 10.7 0.0 1.6 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_32 PF13679.6 CRG82931.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 CRG82931.1 - 0.11 11.9 0.0 1.7 8.1 0.0 2.3 2 1 0 2 2 2 0 Putative methyltransferase Methyltransf_29 PF03141.16 CRG82931.1 - 0.13 10.8 0.0 0.17 10.4 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase TPR_12 PF13424.6 CRG82932.1 - 0.052 13.8 0.1 10 6.5 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Acetyltransf_1 PF00583.25 CRG82933.1 - 7.4e-08 32.6 0.0 1.2e-07 32.0 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG82933.1 - 4e-05 23.6 0.0 0.00024 21.0 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG82933.1 - 6.8e-05 23.2 0.1 0.0002 21.7 0.0 1.8 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain zinc_ribbon_16 PF17034.5 CRG82933.1 - 0.054 13.7 0.0 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 Zinc-ribbon like family Sugar_tr PF00083.24 CRG82934.1 - 1.1e-131 439.8 23.1 1.3e-131 439.6 23.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG82934.1 - 8.1e-24 84.2 31.4 8.3e-15 54.6 11.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG82934.1 - 6.2e-06 25.0 17.4 0.004 15.8 7.7 2.6 2 1 0 2 2 2 2 MFS/sugar transport protein O_anti_polymase PF01901.16 CRG82934.1 - 0.063 12.5 5.5 0.21 10.8 0.4 2.7 2 1 0 2 2 2 0 Putative O-antigen polymerase EGF PF00008.27 CRG82935.1 - 0.15 12.4 5.2 0.3 11.4 5.2 1.6 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 CRG82935.1 - 0.44 11.3 6.2 1.3 9.8 6.2 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF DUF2749 PF10907.8 CRG82935.1 - 1.2 9.3 3.9 4 7.7 3.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) Glyco_hydro_76 PF03663.14 CRG82937.1 - 1.2e-37 130.3 20.1 1.5e-37 130.0 20.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CRG82937.1 - 1.9e-05 23.9 0.8 0.0015 17.7 0.0 2.9 2 1 0 3 3 3 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 CRG82937.1 - 0.0012 17.4 0.1 0.052 12.0 0.0 2.0 1 1 1 3 3 3 2 Beta-L-arabinofuranosidase, GH127 GlcNAc_2-epim PF07221.11 CRG82937.1 - 0.029 13.6 0.1 3.6 6.8 0.0 3.0 3 0 0 3 3 3 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) His_Phos_2 PF00328.22 CRG82938.1 - 2.8e-43 148.7 0.0 3.9e-43 148.3 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Glyco_hydro_47 PF01532.20 CRG82939.1 - 1.2e-130 436.5 0.1 1.3e-130 436.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF3929 PF13066.6 CRG82939.1 - 0.14 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3929) Glyco_hydro_130 PF04041.13 CRG82940.1 - 2.3e-47 161.5 0.0 2.6e-47 161.3 0.0 1.0 1 0 0 1 1 1 1 beta-1,4-mannooligosaccharide phosphorylase Glyco_hydro_43 PF04616.14 CRG82940.1 - 1.1e-07 31.5 1.4 0.0014 18.1 0.0 3.4 3 1 1 4 4 4 2 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 CRG82940.1 - 8.5e-05 22.3 1.7 0.027 14.0 0.1 2.8 2 1 0 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain Complex1_LYR PF05347.15 CRG82942.1 - 1.5e-16 60.2 6.8 1.5e-16 60.2 6.8 2.1 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CRG82942.1 - 0.00018 22.2 3.0 0.00042 21.0 3.0 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Mg_trans_NIPA PF05653.14 CRG82943.1 - 1.1e-90 303.8 16.4 1.3e-90 303.5 16.4 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CRG82943.1 - 0.0013 18.9 3.5 0.0013 18.9 3.5 3.5 2 2 0 3 3 3 1 EamA-like transporter family DUF2937 PF11157.8 CRG82943.1 - 0.1 12.3 2.4 0.36 10.5 0.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2937) Fungal_trans_2 PF11951.8 CRG82944.1 - 1.9e-06 27.0 1.6 2.3e-06 26.7 1.6 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG82945.1 - 1.9e-20 73.1 0.0 3e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG82945.1 - 9.5e-15 54.8 0.0 1.8e-13 50.6 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG82945.1 - 1.5e-05 25.0 0.1 2.5e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG82945.1 - 0.0039 16.4 0.0 0.0063 15.7 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 CRG82945.1 - 0.13 12.3 0.1 0.36 10.9 0.1 1.9 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Hydrolase_4 PF12146.8 CRG82946.1 - 2.2e-13 50.1 0.0 3.3e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG82946.1 - 1.8e-11 45.1 0.0 2.2e-11 44.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG82946.1 - 7.8e-08 32.3 0.0 3.9e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CRG82946.1 - 0.019 15.0 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Peptidase_S9 PF00326.21 CRG82946.1 - 0.094 12.2 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family SET PF00856.28 CRG82947.1 - 9.5e-14 52.1 0.3 9.5e-14 52.1 0.3 4.2 4 2 0 4 4 4 1 SET domain AWS PF17907.1 CRG82947.1 - 7e-08 32.4 10.1 7e-08 32.4 10.1 2.2 2 0 0 2 2 2 1 AWS domain DHHC PF01529.20 CRG82948.1 - 2.9e-34 118.1 4.7 2.9e-34 118.1 4.7 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase B12D PF06522.11 CRG82949.1 - 0.053 13.3 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PMT PF02366.18 CRG82950.1 - 1.4e-81 273.7 15.2 2.6e-81 272.8 15.2 1.5 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CRG82950.1 - 7e-67 224.9 9.3 7e-67 224.9 9.3 2.1 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CRG82950.1 - 1.5e-43 148.8 0.0 2.6e-43 148.1 0.0 1.3 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 CRG82950.1 - 0.0052 17.0 8.3 0.0052 17.0 8.3 2.3 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase DUF2530 PF10745.9 CRG82950.1 - 0.074 13.3 0.5 1.7 8.9 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) PRP21_like_P PF12230.8 CRG82951.1 - 1.3e-57 195.2 13.1 7.1e-57 192.8 13.1 2.0 1 1 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 CRG82951.1 - 3.1e-39 132.7 2.9 8.7e-20 70.5 0.0 2.8 3 0 0 3 3 3 2 Surp module rRNA_processing PF08524.11 CRG82951.1 - 0.014 15.4 8.2 0.23 11.5 6.3 2.6 2 0 0 2 2 2 0 rRNA processing zf_UBZ PF18439.1 CRG82951.1 - 0.016 14.8 0.2 0.043 13.4 0.2 1.8 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger MscS_TM PF12794.7 CRG82951.1 - 0.44 9.4 1.8 1.1 8.0 1.8 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 FA_hydroxylase PF04116.13 CRG82952.1 - 5.6e-17 62.3 10.2 5.6e-17 62.3 10.2 2.1 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Sec2p PF06428.11 CRG82953.1 - 2.6e-28 97.8 21.6 2.6e-28 97.8 21.6 2.6 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p Macoilin PF09726.9 CRG82953.1 - 0.0024 16.5 19.5 0.0039 15.8 19.5 1.3 1 0 0 1 1 1 1 Macoilin family GCN5L1 PF06320.13 CRG82953.1 - 0.03 14.5 18.1 0.055 13.6 13.9 2.3 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF3584 PF12128.8 CRG82953.1 - 0.53 7.7 23.5 0.81 7.1 23.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GREB1 PF15782.5 CRG82953.1 - 1.4 6.0 9.0 2.1 5.4 9.0 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Fib_alpha PF08702.10 CRG82953.1 - 3.9 7.7 17.1 3.2 7.9 10.9 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Golgin_A5 PF09787.9 CRG82953.1 - 5.1 6.5 24.1 15 4.9 23.6 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 5 ADIP PF11559.8 CRG82953.1 - 7.3 6.7 28.2 9.1 6.4 2.4 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding dsDNA_bind PF01984.20 CRG82954.1 - 8.2e-39 132.3 12.5 9.5e-39 132.1 12.5 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain DUF4615 PF15393.6 CRG82954.1 - 0.0056 17.3 1.2 0.0064 17.1 0.6 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4615) CDT1_C PF16679.5 CRG82954.1 - 0.21 12.0 2.8 0.18 12.2 1.8 1.5 1 1 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Coq4 PF05019.13 CRG82955.1 - 3e-92 308.0 0.0 3.6e-92 307.7 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 SET PF00856.28 CRG82956.1 - 2.5e-19 70.3 0.0 4.1e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 SET domain DUF349 PF03993.12 CRG82956.1 - 0.02 15.2 2.2 0.31 11.4 0.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) ApbA_C PF08546.11 CRG82957.1 - 1.5e-32 112.5 0.3 2.3e-32 111.8 0.3 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 CRG82957.1 - 2.7e-23 82.3 0.0 7.3e-20 71.2 0.0 2.2 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA Helicase_Sgs1 PF11408.8 CRG82957.1 - 0.094 12.8 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Sgs1 RecQ helicase Sas10_Utp3 PF04000.15 CRG82958.1 - 6.6e-16 58.7 2.1 6.6e-16 58.7 2.1 2.4 2 1 0 2 2 2 1 Sas10/Utp3/C1D family adh_short_C2 PF13561.6 CRG82959.1 - 5.9e-44 150.4 0.1 6.8e-44 150.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG82959.1 - 1.2e-35 122.8 0.1 1.4e-35 122.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG82959.1 - 6.5e-09 35.9 0.1 7.8e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG82959.1 - 0.014 14.9 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG82959.1 - 0.036 13.5 0.1 0.063 12.7 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans_2 PF11951.8 CRG82960.1 - 1.9e-08 33.6 0.1 2.7e-08 33.0 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Adeno_VII PF03228.14 CRG82960.1 - 0.0041 17.7 0.0 4.7 7.9 0.1 2.2 2 0 0 2 2 2 2 Adenoviral core protein VII DUF2076 PF09849.9 CRG82961.1 - 3.3e-10 40.4 11.6 4e-10 40.2 11.6 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 CRG82961.1 - 2e-05 24.6 1.9 3.1e-05 24.0 1.9 1.4 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 CRG82961.1 - 0.0027 17.7 1.0 0.0047 16.9 1.0 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Antimicrobial24 PF16049.5 CRG82961.1 - 0.29 11.1 1.5 0.66 10.0 1.5 1.6 1 0 0 1 1 1 0 Frog antimicrobial peptide TFIIA PF03153.13 CRG82961.1 - 2.7 7.9 7.2 3.1 7.7 7.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Retinal PF15449.6 CRG82961.1 - 9.7 3.8 15.0 11 3.7 15.0 1.0 1 0 0 1 1 1 0 Retinal protein UBX PF00789.20 CRG82962.1 - 3.6e-10 39.9 0.0 7.4e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 UBX domain TFIIA PF03153.13 CRG82962.1 - 0.0085 16.1 18.8 0.013 15.6 18.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SURF1 PF02104.15 CRG82963.1 - 8.1e-45 153.2 0.0 1.2e-44 152.7 0.0 1.2 1 0 0 1 1 1 1 SURF1 family CENP-T_C PF15511.6 CRG82964.1 - 3.1e-45 152.7 0.1 4.6e-45 152.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CRG82964.1 - 3.8e-09 36.8 0.2 6.8e-09 36.0 0.2 1.4 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 CRG82964.1 - 2.3e-05 24.7 0.1 5e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CRG82964.1 - 0.011 16.0 0.1 0.02 15.1 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CMS1 PF14617.6 CRG82965.1 - 1.1e-73 247.7 3.1 1.1e-73 247.7 3.1 1.5 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 CRG82965.1 - 3.1e-05 23.8 0.0 3.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Macoilin PF09726.9 CRG82965.1 - 0.029 12.9 5.4 0.031 12.9 5.4 1.1 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 CRG82965.1 - 2.6 7.2 5.0 3.2 6.9 5.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Methyltransf_23 PF13489.6 CRG82966.1 - 9.1e-21 74.4 0.0 1.5e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG82966.1 - 2.2e-11 44.3 0.0 8.4e-11 42.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG82966.1 - 3.7e-09 37.1 0.0 9e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG82966.1 - 7.4e-09 36.3 0.0 1.3e-07 32.3 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG82966.1 - 1.4e-08 34.7 0.0 0.00044 20.1 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.17 CRG82966.1 - 0.0014 18.1 0.3 0.0069 15.9 0.0 2.2 3 0 0 3 3 3 1 Putative methyltransferase CMAS PF02353.20 CRG82966.1 - 0.003 16.9 0.0 0.0095 15.3 0.0 1.8 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 CRG82966.1 - 0.019 15.0 0.0 0.11 12.6 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 CRG82966.1 - 0.028 14.1 0.0 0.22 11.2 0.0 2.1 2 0 0 2 2 2 0 Lysine methyltransferase PrmA PF06325.13 CRG82966.1 - 0.049 13.0 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CRG82966.1 - 0.057 13.0 0.0 0.25 10.9 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain DUF938 PF06080.12 CRG82966.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF938) RRM_1 PF00076.22 CRG82967.1 - 2.5e-12 46.4 1.4 4.6e-12 45.6 0.1 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ras PF00071.22 CRG82968.1 - 9.2e-55 184.7 0.0 1.1e-54 184.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG82968.1 - 1.7e-20 73.5 0.0 2.5e-20 72.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG82968.1 - 3.8e-07 29.7 0.0 4.9e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family ABM PF03992.16 CRG82969.1 - 3e-11 43.3 0.1 5.3e-11 42.5 0.1 1.4 1 1 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Beta-lactamase PF00144.24 CRG82970.1 - 4.4e-49 167.5 0.3 7.4e-49 166.8 0.3 1.3 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CRG82970.1 - 3.2e-09 37.2 0.0 6.4e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Hydrophobin PF01185.18 CRG82971.1 - 0.0015 19.1 8.4 0.0024 18.4 8.4 1.3 1 0 0 1 1 1 1 Fungal hydrophobin GRP PF07172.11 CRG82972.1 - 0.26 12.0 27.8 0.59 10.9 27.8 1.6 1 0 0 1 1 1 0 Glycine rich protein family Fungal_trans PF04082.18 CRG82973.1 - 7.4e-08 31.7 1.0 1e-07 31.3 0.2 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG82973.1 - 9.2e-07 28.9 10.7 1.7e-06 28.1 10.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RhoGAP PF00620.27 CRG82974.1 - 2.3e-50 170.4 0.0 1.2e-49 168.0 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 CRG82974.1 - 1.6e-11 44.3 1.9 1.6e-11 44.3 1.9 2.4 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF3087 PF11286.8 CRG82974.1 - 0.036 13.5 0.5 0.07 12.6 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3087) DUF1664 PF07889.12 CRG82974.1 - 0.21 11.6 4.5 0.22 11.6 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 CRG82974.1 - 7.4 6.7 19.5 13 5.9 1.2 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 CRG82974.1 - 10 5.8 20.3 0.58 9.9 3.6 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF745) Ytp1 PF10355.9 CRG82975.1 - 4.2e-113 377.2 6.1 7.3e-113 376.4 6.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CRG82975.1 - 4.3e-33 113.2 12.7 1.8e-31 108.0 5.6 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF2427) Gly_transf_sug PF04488.15 CRG82976.1 - 2.3e-19 69.8 0.1 4.6e-19 68.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif GGACT PF06094.12 CRG82977.1 - 9.6e-11 42.4 0.0 1.2e-10 42.0 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like MFS_1 PF07690.16 CRG82978.1 - 3.4e-53 180.8 37.3 1.9e-48 165.2 23.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG82978.1 - 6.6e-15 54.9 6.2 6.6e-15 54.9 6.2 2.0 1 1 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 CRG82978.1 - 1.7e-10 39.8 2.1 1.7e-10 39.8 2.1 2.6 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 CRG82978.1 - 7.6e-10 37.9 27.1 6.8e-06 24.9 8.0 3.3 2 2 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 CRG82978.1 - 4.3e-05 22.6 21.1 0.00011 21.2 8.3 3.4 1 1 1 3 3 3 2 MFS_1 like family MFS_3 PF05977.13 CRG82978.1 - 0.00027 19.5 15.4 0.00035 19.1 3.2 2.3 2 0 0 2 2 2 2 Transmembrane secretion effector UPF0060 PF02694.15 CRG82978.1 - 0.0008 19.6 5.3 0.66 10.2 0.8 3.2 2 0 0 2 2 2 2 Uncharacterised BCR, YnfA/UPF0060 family MFS_4 PF06779.14 CRG82978.1 - 0.007 15.7 17.8 0.054 12.8 8.6 3.0 2 2 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB PTR2 PF00854.21 CRG82978.1 - 0.045 12.6 2.7 0.9 8.3 0.9 2.5 2 1 1 3 3 3 0 POT family RRM_1 PF00076.22 CRG82979.1 - 0.00076 19.3 0.0 0.0019 18.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mis14 PF08641.12 CRG82979.1 - 0.028 14.7 0.7 0.028 14.7 0.7 2.2 2 0 0 2 2 2 0 Kinetochore protein Mis14 like Med12 PF09497.10 CRG82980.1 - 3.9e-28 97.5 0.1 4.2e-27 94.2 0.1 2.6 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Zn_clus PF00172.18 CRG82980.1 - 5.8e-05 23.1 4.2 5.8e-05 23.1 4.2 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med12-LCEWAV PF12145.8 CRG82980.1 - 0.035 13.0 0.9 0.095 11.5 0.1 2.0 2 0 0 2 2 2 0 Eukaryotic Mediator 12 subunit domain Cnd1 PF12717.7 CRG82980.1 - 0.073 13.1 0.0 0.31 11.1 0.0 2.1 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 UPF0139 PF03669.13 CRG82981.1 - 2.5e-06 27.3 0.1 3.3e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) AWPM-19 PF05512.11 CRG82981.1 - 0.074 13.2 0.0 0.088 13.0 0.0 1.1 1 0 0 1 1 1 0 AWPM-19-like family SUI1 PF01253.22 CRG82982.1 - 4.3e-28 97.7 3.9 5.6e-28 97.3 3.9 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 EOS1 PF12326.8 CRG82983.1 - 5.3e-14 52.5 7.0 5.3e-14 52.5 7.0 2.5 2 1 0 3 3 3 1 N-glycosylation protein Voldacs PF03517.13 CRG82983.1 - 0.038 14.1 1.6 0.069 13.3 1.6 1.3 1 0 0 1 1 1 0 Regulator of volume decrease after cellular swelling DUF3246 PF11596.8 CRG82983.1 - 0.91 8.9 13.3 0.02 14.3 6.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) MBA1 PF07961.11 CRG82984.1 - 6.5e-06 25.4 0.0 1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 MBA1-like protein Tim44 PF04280.15 CRG82984.1 - 6e-05 23.2 0.1 0.00013 22.1 0.1 1.5 1 0 0 1 1 1 1 Tim44-like domain ECH_1 PF00378.20 CRG82985.1 - 3.6e-40 137.9 0.3 1.5e-39 135.9 0.3 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG82985.1 - 5.6e-18 65.5 0.3 2e-17 63.7 0.3 1.7 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF4470 PF14737.6 CRG82986.1 - 7e-22 77.4 0.0 2.2e-21 75.9 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) APH PF01636.23 CRG82986.1 - 7.3e-08 32.6 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF4904 PF16247.5 CRG82987.1 - 0.0036 17.1 0.1 0.29 11.0 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF4904) Cys_Met_Meta_PP PF01053.20 CRG82987.1 - 0.16 10.4 0.0 0.26 9.8 0.0 1.6 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme PhyH PF05721.13 CRG82988.1 - 0.0011 19.3 0.4 0.0095 16.2 0.4 2.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AveC_like PF17198.4 CRG82989.1 - 0.065 12.7 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Spirocyclase AveC-like CIA30 PF08547.12 CRG82990.1 - 1.7e-37 128.9 0.0 8.8e-25 87.6 0.0 2.3 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) ANAPC5 PF12862.7 CRG82990.1 - 5.7e-36 122.5 1.7 5.7e-36 122.5 1.7 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_12 PF13424.6 CRG82990.1 - 2e-06 28.0 4.0 0.15 12.4 0.1 4.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 CRG82990.1 - 4.5e-05 23.2 0.3 0.021 14.7 0.1 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 CRG82990.1 - 0.0012 19.3 0.9 0.075 13.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG82990.1 - 0.0025 17.2 2.8 0.017 14.5 1.4 2.3 2 0 0 2 2 2 1 MalT-like TPR region TPR_4 PF07721.14 CRG82990.1 - 0.0048 17.4 0.1 2.3 9.1 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG82990.1 - 0.0052 16.8 0.2 0.26 11.5 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG82990.1 - 0.0099 15.9 0.4 4.5 7.5 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 CRG82990.1 - 0.01 16.0 1.8 1.5 9.1 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CRG82990.1 - 0.034 14.4 0.4 2.4 8.6 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG82990.1 - 0.12 13.0 3.4 23 5.7 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat SAICAR_synt PF01259.18 CRG82991.1 - 4.6e-97 324.6 0.0 5.5e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase polyprenyl_synt PF00348.17 CRG82992.1 - 5.4e-72 241.9 0.0 1.5e-71 240.5 0.0 1.6 1 1 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 CRG82992.1 - 0.0028 17.3 0.0 0.0043 16.7 0.0 1.2 1 0 0 1 1 1 1 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Rpn3_C PF08375.11 CRG82993.1 - 1.1e-25 89.8 1.3 1.1e-25 89.8 1.3 2.2 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 CRG82993.1 - 1.2e-18 67.6 0.1 1.2e-17 64.3 0.0 2.6 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 CRG82993.1 - 0.038 14.1 0.0 0.15 12.3 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 CRG82993.1 - 0.11 12.4 0.5 1.1 9.2 0.1 2.8 3 1 0 3 3 3 0 CSN8/PSMD8/EIF3K family Sigma70_r1_2 PF00140.20 CRG82993.1 - 0.89 9.6 3.8 0.75 9.9 1.4 2.1 2 0 0 2 2 2 0 Sigma-70 factor, region 1.2 DASH_Spc34 PF08657.10 CRG82994.1 - 2.4e-42 145.5 11.1 4e-21 76.0 6.6 2.0 1 1 1 2 2 2 2 DASH complex subunit Spc34 DUF724 PF05266.14 CRG82994.1 - 0.0047 16.8 0.8 0.0047 16.8 0.8 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF724) FapA PF03961.13 CRG82994.1 - 0.013 14.2 1.1 0.017 13.8 1.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A ING PF12998.7 CRG82994.1 - 0.029 15.0 3.5 0.063 13.9 3.5 1.5 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding DUF1664 PF07889.12 CRG82994.1 - 0.063 13.3 2.4 0.13 12.3 2.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2315 PF10231.9 CRG82994.1 - 0.083 13.0 0.8 0.15 12.2 0.8 1.4 1 0 0 1 1 1 0 Apoptogenic protein 1 FTA4 PF13093.6 CRG82994.1 - 0.11 12.4 5.4 0.15 12.0 4.8 1.3 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Coa1 PF08695.10 CRG82994.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome oxidase complex assembly protein 1 Fib_alpha PF08702.10 CRG82994.1 - 0.17 12.1 2.8 0.36 11.0 2.8 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DASH_Spc19 PF08287.11 CRG82994.1 - 1.4 8.8 10.0 0.24 11.3 5.5 1.8 2 0 0 2 2 2 0 Spc19 ZapB PF06005.12 CRG82994.1 - 2.4 8.7 8.9 0.87 10.1 1.7 2.5 1 1 0 2 2 2 0 Cell division protein ZapB Uds1 PF15456.6 CRG82994.1 - 8.4 6.6 10.9 30 4.8 11.0 2.2 1 1 0 1 1 1 0 Up-regulated During Septation TFIID_20kDa PF03847.13 CRG82995.1 - 1.2e-21 77.0 0.0 8e-21 74.3 0.0 2.1 2 0 0 2 2 2 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 CRG82995.1 - 0.061 13.7 0.0 0.061 13.7 0.0 4.0 4 1 1 5 5 5 0 Core histone H2A/H2B/H3/H4 CorA PF01544.18 CRG82996.1 - 7.5e-14 51.7 0.2 1.2e-13 51.0 0.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2207 PF09972.9 CRG82996.1 - 0.12 11.1 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PIP5K PF01504.18 CRG82997.1 - 2.4e-101 338.6 0.0 2.4e-101 338.6 0.0 2.2 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase SUIM_assoc PF16619.5 CRG82997.1 - 0.033 14.3 6.3 0.19 11.8 6.3 2.3 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF3926 PF13080.6 CRG82997.1 - 0.064 13.2 0.1 0.22 11.5 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) Spt20 PF12090.8 CRG82997.1 - 0.15 11.7 4.7 0.26 10.9 4.7 1.3 1 0 0 1 1 1 0 Spt20 family adh_short PF00106.25 CRG82998.1 - 6.1e-09 35.6 0.0 4.3e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG82998.1 - 0.00071 19.5 0.1 0.0019 18.1 0.0 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 CRG82998.1 - 0.0091 15.6 0.0 0.025 14.1 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 CRG82998.1 - 0.045 14.0 0.1 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Linker_histone PF00538.19 CRG82999.1 - 5.5e-31 106.8 0.5 5.5e-31 106.8 0.5 1.8 2 0 0 2 2 2 1 linker histone H1 and H5 family TetR_C_24 PF17932.1 CRG82999.1 - 0.094 13.0 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain XPG_N PF00752.17 CRG83000.1 - 8.5e-32 109.6 0.8 4.4e-31 107.3 0.0 2.3 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 CRG83000.1 - 4.9e-31 107.0 1.8 6.2e-31 106.6 0.0 2.1 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 CRG83000.1 - 1.1e-05 26.0 0.1 5.2e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Fe_dep_repr_C PF02742.15 CRG83000.1 - 0.34 11.0 2.8 8.3 6.6 0.0 3.3 4 0 0 4 4 4 0 Iron dependent repressor, metal binding and dimerisation domain Zn_clus PF00172.18 CRG83001.1 - 3e-08 33.7 8.3 4.8e-08 33.0 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG83001.1 - 6.9e-05 22.0 0.1 0.00016 20.8 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_6 PF08030.12 CRG83003.1 - 3.6e-33 114.9 0.0 6.3e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG83003.1 - 4.5e-21 75.0 0.0 1.4e-20 73.4 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CRG83003.1 - 3e-20 72.6 17.4 1.1e-19 70.7 10.7 2.4 1 1 1 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 CRG83003.1 - 0.077 13.7 0.0 0.28 11.9 0.0 2.0 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Acyl-CoA_dh_N PF02771.16 CRG83004.1 - 1.3e-25 90.2 0.1 2.9e-25 89.1 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 CRG83004.1 - 2.9e-24 86.0 0.4 4.9e-24 85.2 0.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CRG83004.1 - 1.9e-17 63.2 0.0 3.7e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CRG83004.1 - 4.4e-08 33.5 1.7 8.1e-08 32.6 1.7 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain UQ_con PF00179.26 CRG83005.1 - 5.1e-52 175.2 0.0 5.8e-52 175.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CRG83005.1 - 0.048 13.9 0.0 0.059 13.7 0.0 1.2 1 0 0 1 1 1 0 RWD domain UEV PF05743.13 CRG83005.1 - 0.058 13.3 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 UEV domain Prok-E2_B PF14461.6 CRG83005.1 - 0.071 12.8 0.0 0.086 12.5 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic E2 family B Glyoxalase PF00903.25 CRG83006.1 - 0.0028 17.9 0.8 0.0075 16.5 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Gly-zipper_Omp PF13488.6 CRG83006.1 - 0.28 11.2 7.1 0.64 10.1 7.1 1.5 1 0 0 1 1 1 0 Glycine zipper EMG1 PF03587.14 CRG83007.1 - 1.2e-79 266.5 0.0 1.4e-79 266.3 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 CRG83007.1 - 0.034 13.9 0.0 0.069 12.9 0.0 1.4 2 0 0 2 2 2 0 Uncharacterized protein RP854 APH PF01636.23 CRG83008.1 - 9.4e-22 78.1 0.0 1.2e-21 77.8 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG83008.1 - 2.2e-06 27.4 0.0 3.5e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 CRG83008.1 - 0.003 16.9 0.0 0.0048 16.3 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Acetyltransf_13 PF13880.6 CRG83009.1 - 2.8e-27 94.5 0.0 8.9e-27 92.9 0.0 1.9 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 CRG83009.1 - 7.5e-13 48.1 0.2 1.8e-12 46.9 0.2 1.7 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO GRDP-like PF07173.12 CRG83009.1 - 0.02 15.6 0.2 1.5 9.5 0.0 2.4 2 0 0 2 2 2 0 Glycine-rich domain-containing protein-like TolA_bind_tri PF16331.5 CRG83010.1 - 0.012 15.7 0.1 0.062 13.4 0.0 2.1 2 0 0 2 2 2 0 TolA binding protein trimerisation eIF2A PF08662.11 CRG83012.1 - 6.4e-80 267.6 0.0 3.4e-79 265.2 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 CRG83012.1 - 0.0014 19.4 0.8 0.57 11.1 0.0 4.2 4 0 0 4 4 4 1 WD domain, G-beta repeat PD40 PF07676.12 CRG83012.1 - 0.02 14.8 0.5 5 7.2 0.0 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 CRG83012.1 - 0.041 12.4 0.0 0.07 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain IKI3 PF04762.12 CRG83012.1 - 0.13 10.2 0.0 0.2 9.6 0.0 1.2 1 0 0 1 1 1 0 IKI3 family Glyco_trans_2_3 PF13632.6 CRG83014.1 - 8.7e-17 61.7 12.7 8.7e-17 61.7 12.7 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CRG83014.1 - 1.2e-16 61.4 0.0 1.6e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CRG83014.1 - 0.0017 17.8 0.1 0.0031 17.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CRG83014.1 - 0.0022 17.8 0.1 0.0032 17.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF423 PF04241.15 CRG83014.1 - 2.4 8.4 5.5 5.1 7.4 0.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF423) Glyco_hydro_16 PF00722.21 CRG83015.1 - 1.7e-07 30.9 0.3 3.8e-07 29.7 0.3 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Acyl_transf_3 PF01757.22 CRG83015.1 - 0.00019 20.6 36.8 0.00038 19.6 36.8 1.5 1 0 0 1 1 1 1 Acyltransferase family Ribonuclease PF00545.20 CRG83016.1 - 1.6e-07 32.0 0.1 2.2e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 ribonuclease SSF PF00474.17 CRG83018.1 - 5.7e-21 74.8 30.7 9.8e-21 74.1 30.7 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family DUF3716 PF12511.8 CRG83018.1 - 9.4e-05 22.4 4.3 0.00016 21.7 4.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) ADH_N PF08240.12 CRG83020.1 - 4.8e-06 26.4 0.1 1.1e-05 25.2 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG83020.1 - 0.0018 18.3 0.0 0.0035 17.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DSBA PF01323.20 CRG83021.1 - 8.1e-21 74.7 0.0 1e-20 74.4 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain MscL PF01741.18 CRG83023.1 - 3.7e-21 75.7 0.1 4.5e-21 75.4 0.1 1.1 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL zf-BED PF02892.15 CRG83023.1 - 0.085 12.9 2.1 0.14 12.2 2.1 1.4 1 0 0 1 1 1 0 BED zinc finger zf-C2H2_2 PF12756.7 CRG83024.1 - 0.029 14.7 0.0 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 CRG83024.1 - 0.095 13.2 3.2 0.26 11.8 3.2 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG83024.1 - 0.25 12.3 3.3 0.73 10.8 3.3 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger p450 PF00067.22 CRG83025.1 - 7.7e-63 212.8 0.0 9.8e-63 212.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 CRG83026.1 - 3.9e-80 269.9 26.7 4.7e-80 269.6 26.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83026.1 - 2.1e-20 73.0 36.4 5.2e-19 68.4 27.9 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG83026.1 - 4 6.2 23.1 0.0069 15.3 7.2 2.4 2 1 0 2 2 2 0 MFS_1 like family Acetyltransf_1 PF00583.25 CRG83027.1 - 3.2e-11 43.5 0.0 4.2e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG83027.1 - 9.8e-09 35.2 0.0 1.4e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG83027.1 - 1.7e-08 34.8 0.0 2.4e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG83027.1 - 0.011 15.9 0.0 0.036 14.1 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG83027.1 - 0.012 15.8 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 CRG83027.1 - 0.058 13.5 0.0 0.13 12.4 0.0 1.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PPP4R2 PF09184.11 CRG83028.1 - 3.4 7.2 10.2 5.6 6.5 10.2 1.3 1 0 0 1 1 1 0 PPP4R2 MFS_1 PF07690.16 CRG83029.1 - 4.1e-30 104.9 44.9 2.3e-28 99.2 36.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83029.1 - 1.7e-10 40.4 16.0 1.7e-10 40.4 16.0 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter LapA_dom PF06305.11 CRG83029.1 - 4.1 7.3 11.5 0.93 9.3 0.8 4.2 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain LIP PF03583.14 CRG83030.1 - 8.7e-58 195.9 0.0 1.1e-57 195.5 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Abhydrolase_6 PF12697.7 CRG83031.1 - 1.5e-13 51.8 0.7 2.4e-13 51.2 0.7 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG83031.1 - 3e-08 33.6 0.1 4.2e-07 29.9 0.2 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold LIP PF03583.14 CRG83031.1 - 0.055 12.8 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Secretory lipase Glyco_hydro_71 PF03659.14 CRG83032.1 - 1.7e-93 313.5 5.9 1.9e-93 313.3 5.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Rieske PF00355.26 CRG83033.1 - 1.3 9.0 10.8 26 4.9 0.1 5.0 5 1 1 6 6 6 0 Rieske [2Fe-2S] domain Glyco_transf_8 PF01501.20 CRG83034.1 - 1.1e-16 61.2 0.0 6.1e-16 58.7 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 8 ABC_tran PF00005.27 CRG83035.1 - 4.8e-44 150.2 0.0 1.7e-26 93.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG83035.1 - 4.3e-33 115.1 24.5 2.1e-20 73.5 14.9 3.5 3 1 0 3 3 3 3 ABC transporter transmembrane region SMC_N PF02463.19 CRG83035.1 - 5.1e-12 45.7 2.4 1.6e-06 27.8 0.8 4.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG83035.1 - 3.5e-06 27.1 0.3 0.62 9.8 0.0 4.2 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CRG83035.1 - 4.2e-06 27.1 1.7 0.015 15.6 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CRG83035.1 - 0.00011 22.8 1.6 0.0065 17.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CRG83035.1 - 0.0006 20.2 0.1 2.2 8.6 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CRG83035.1 - 0.00085 19.3 0.2 1.1 9.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CRG83035.1 - 0.001 18.8 3.4 0.14 11.9 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain cobW PF02492.19 CRG83035.1 - 0.0048 16.5 0.5 0.11 12.1 0.1 2.8 3 0 0 3 3 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 CRG83035.1 - 0.0061 16.6 0.1 0.37 10.9 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 CRG83035.1 - 0.013 15.4 0.2 5.3 6.9 0.0 2.6 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 CRG83035.1 - 0.014 14.4 0.4 4.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_33 PF13671.6 CRG83035.1 - 0.048 13.8 0.1 16 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF2147 PF09917.9 CRG83035.1 - 0.06 14.0 0.2 0.26 11.9 0.1 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) DUF87 PF01935.17 CRG83035.1 - 0.064 13.3 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_25 PF13481.6 CRG83035.1 - 0.074 12.6 3.1 0.076 12.6 0.1 2.3 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CRG83035.1 - 0.16 12.2 0.0 33 4.8 0.0 2.9 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 CRG83035.1 - 0.2 11.3 1.6 5.3 6.7 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.6 CRG83035.1 - 0.24 11.1 0.0 7.6 6.1 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 CRG83035.1 - 0.26 11.3 0.5 13 5.8 0.1 2.8 2 0 0 2 2 2 0 Dynamin family DUF2075 PF09848.9 CRG83035.1 - 1.4 8.0 3.4 14 4.8 0.1 2.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) Lipase_2 PF01674.18 CRG83036.1 - 8.8e-06 25.4 0.0 1.7e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Lipase (class 2) Abhydrolase_1 PF00561.20 CRG83036.1 - 2e-05 24.4 0.1 0.0001 22.1 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG83036.1 - 0.00036 21.2 0.1 0.00048 20.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG83036.1 - 0.0068 15.7 0.0 0.015 14.6 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CRG83036.1 - 0.0094 15.7 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_2 PF02230.16 CRG83036.1 - 0.023 14.5 0.0 0.79 9.5 0.0 2.6 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase DUF900 PF05990.12 CRG83036.1 - 0.049 13.1 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF2974 PF11187.8 CRG83036.1 - 0.096 12.2 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) LIDHydrolase PF10230.9 CRG83036.1 - 0.14 11.7 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Fungal_trans_2 PF11951.8 CRG83037.1 - 3e-06 26.3 0.0 1.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83037.1 - 3.4e-05 23.9 13.0 6.3e-05 23.0 13.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PNP_UDP_1 PF01048.20 CRG83037.1 - 0.14 11.3 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Phosphorylase superfamily FAM104 PF15434.6 CRG83037.1 - 0.22 12.1 3.5 0.57 10.8 3.5 1.7 1 0 0 1 1 1 0 Family 104 MFS_1 PF07690.16 CRG83038.1 - 1e-37 129.9 30.7 2.6e-36 125.3 33.0 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Pentapeptide_4 PF13599.6 CRG83038.1 - 3.4e-08 33.5 2.9 3.2e-05 24.0 0.1 3.4 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) DUF2627 PF11118.8 CRG83038.1 - 0.12 13.0 3.1 8.6 7.0 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2627) Fungal_trans_2 PF11951.8 CRG83039.1 - 8.7e-07 28.1 0.1 3.2e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Bromo_TP PF07524.13 CRG83039.1 - 0.054 13.5 0.1 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 Bromodomain associated GlutR_N PF05201.15 CRG83039.1 - 0.076 12.8 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, N-terminal domain Peptidase_S10 PF00450.22 CRG83040.1 - 5.1e-72 243.6 3.2 7.8e-72 243.0 3.2 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase Sugar_tr PF00083.24 CRG83041.1 - 1.4e-117 393.3 22.2 1.8e-117 393.0 22.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83041.1 - 8.5e-24 84.1 39.8 8.9e-23 80.8 30.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG83041.1 - 0.002 16.7 3.9 0.002 16.7 3.9 1.8 3 0 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) ATP-synt_ab PF00006.25 CRG83042.1 - 7.7e-62 208.7 0.0 1.5e-61 207.8 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CRG83042.1 - 1.5e-22 79.8 0.3 6.2e-22 77.9 0.2 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 CRG83042.1 - 0.012 14.9 0.2 0.022 14.1 0.2 1.4 1 0 0 1 1 1 0 KaiC AAA PF00004.29 CRG83042.1 - 0.014 15.8 0.0 0.9 10.0 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CRG83042.1 - 0.017 15.0 0.2 0.044 13.7 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase NB-ARC PF00931.22 CRG83042.1 - 0.02 14.1 0.3 0.11 11.6 0.1 2.0 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 CRG83042.1 - 0.04 13.8 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 CRG83042.1 - 0.041 14.2 1.0 0.48 10.7 0.2 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CRG83042.1 - 0.058 13.3 0.2 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain T3SS_ATPase_C PF18269.1 CRG83042.1 - 0.066 13.1 0.7 0.27 11.1 0.7 1.9 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RNA_helicase PF00910.22 CRG83042.1 - 0.099 13.0 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase COX4 PF02936.14 CRG83043.1 - 8.8e-47 158.6 0.5 1.1e-46 158.3 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF3106 PF11304.8 CRG83043.1 - 0.033 14.6 1.8 0.033 14.6 1.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) DUF1104 PF06518.11 CRG83043.1 - 0.06 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) B12D PF06522.11 CRG83043.1 - 0.15 11.8 0.3 4.9 7.0 0.0 2.5 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Cofilin_ADF PF00241.20 CRG83044.1 - 8.5e-34 116.0 0.0 9.7e-34 115.8 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SpoVR PF04293.13 CRG83044.1 - 0.066 11.9 0.0 0.083 11.6 0.0 1.1 1 0 0 1 1 1 0 SpoVR like protein GST_N_2 PF13409.6 CRG83045.1 - 3.3e-15 56.1 0.0 6e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CRG83045.1 - 7.1e-15 55.2 0.0 1.2e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG83045.1 - 1.5e-13 50.9 0.0 2.6e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 CRG83045.1 - 4.6e-05 23.5 0.0 8.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_C_5 PF16865.5 CRG83045.1 - 0.0014 19.2 0.0 0.0022 18.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ACBP PF00887.19 CRG83046.1 - 2.2e-22 79.1 0.0 6.1e-22 77.6 0.0 1.8 1 0 0 1 1 1 1 Acyl CoA binding protein CDC45 PF02724.14 CRG83046.1 - 0.00016 20.1 0.9 0.00027 19.4 0.9 1.3 1 0 0 1 1 1 1 CDC45-like protein NOA36 PF06524.12 CRG83046.1 - 5.8 6.2 5.1 9.2 5.5 5.1 1.3 1 0 0 1 1 1 0 NOA36 protein LSM14 PF12701.7 CRG83047.1 - 2.6e-27 94.7 0.0 4.1e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 CRG83047.1 - 9.7e-19 68.2 7.5 9.7e-19 68.2 7.5 2.0 2 0 0 2 2 2 1 FDF domain SM-ATX PF14438.6 CRG83047.1 - 2.6e-06 27.5 0.0 5e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain Mitofilin PF09731.9 CRG83047.1 - 0.044 12.6 6.0 0.06 12.2 6.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LSM PF01423.22 CRG83047.1 - 0.16 11.7 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 LSM domain Thioredox_DsbH PF03190.15 CRG83048.1 - 6.1e-70 234.4 0.0 1.2e-69 233.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 WD40 PF00400.32 CRG83048.1 - 8.3e-19 67.6 7.8 2.2e-05 25.1 0.1 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Thioredoxin_7 PF13899.6 CRG83048.1 - 2.4e-05 24.4 0.0 5.7e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like ANAPC4_WD40 PF12894.7 CRG83048.1 - 0.00021 21.5 0.1 0.71 10.2 0.0 3.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CRG83048.1 - 0.0054 16.3 0.8 0.058 13.0 0.1 2.4 1 1 1 2 2 2 1 PQQ-like domain Glyco_hydro_9 PF00759.19 CRG83048.1 - 0.0074 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 Mrr_N PF14338.6 CRG83048.1 - 0.055 13.6 0.1 0.18 12.0 0.1 1.8 1 0 0 1 1 1 0 Mrr N-terminal domain Nup160 PF11715.8 CRG83048.1 - 0.08 11.6 0.3 0.84 8.2 0.0 2.4 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 CRG83048.1 - 0.11 13.1 2.1 15 6.2 0.0 4.2 5 0 0 5 5 5 0 PQQ-like domain CAP PF00188.26 CRG83049.1 - 8.3e-17 62.2 1.6 1.3e-16 61.6 1.6 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Fungal_trans PF04082.18 CRG83050.1 - 1e-12 47.7 1.8 7.1e-12 44.9 1.3 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain Mak10 PF04112.13 CRG83051.1 - 4.2e-58 195.6 0.1 2.6e-56 189.8 0.0 2.4 2 0 0 2 2 2 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase ATP-synt_Eps PF04627.13 CRG83052.1 - 6.2e-21 74.1 0.4 9.1e-21 73.6 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain RE_HaeIII PF09556.10 CRG83052.1 - 0.033 13.3 0.0 0.033 13.3 0.0 1.0 1 0 0 1 1 1 0 HaeIII restriction endonuclease HTH_31 PF13560.6 CRG83052.1 - 0.041 14.2 0.4 0.11 12.9 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Rrn6 PF10214.9 CRG83053.1 - 0.9 7.9 13.1 0.71 8.3 9.6 2.0 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Cpn60_TCP1 PF00118.24 CRG83054.1 - 8.3e-86 288.5 12.8 1.6e-85 287.6 12.8 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Chalcone PF02431.15 CRG83054.1 - 0.11 11.9 0.1 0.31 10.4 0.1 1.6 2 0 0 2 2 2 0 Chalcone-flavanone isomerase 4HBT PF03061.22 CRG83055.1 - 6.3e-09 36.1 0.1 1e-08 35.4 0.1 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CRG83055.1 - 0.022 15.0 0.0 0.03 14.6 0.0 1.2 1 0 0 1 1 1 0 Thioesterase-like superfamily CHCH PF06747.13 CRG83056.1 - 9.1e-06 25.7 15.4 9.2e-05 22.5 6.3 2.6 3 0 0 3 3 3 2 CHCH domain CX9C PF16860.5 CRG83056.1 - 0.00015 21.7 8.6 0.0034 17.3 3.9 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 CRG83056.1 - 0.018 15.3 7.8 0.69 10.3 1.2 3.0 2 1 0 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 CRG83056.1 - 0.4 10.7 13.9 2.1 8.4 5.4 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.17 CRG83056.1 - 0.59 10.4 11.6 1.9 8.7 3.4 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb Nup54 PF13874.6 CRG83057.1 - 9.5e-39 132.7 0.0 9.5e-39 132.7 0.0 3.0 3 1 0 3 3 3 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 CRG83057.1 - 5.8e-18 65.5 84.0 4.5e-13 49.8 33.5 3.7 1 1 1 3 3 3 2 Nucleoporin FG repeat region Med26 PF08711.11 CRG83057.1 - 4.6e-11 42.6 0.0 1.3e-10 41.1 0.0 1.8 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Nup54_57_C PF18570.1 CRG83057.1 - 9.8e-10 37.8 2.8 2.2e-09 36.7 2.8 1.6 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain Prominin PF05478.11 CRG83057.1 - 0.06 11.3 1.0 0.089 10.7 1.0 1.1 1 0 0 1 1 1 0 Prominin Spc24 PF08286.11 CRG83057.1 - 0.79 10.0 3.9 2.9 8.2 0.2 3.3 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 HIG_1_N PF04588.13 CRG83058.1 - 4.7e-07 29.9 0.5 4.7e-07 29.9 0.5 1.8 2 0 0 2 2 2 1 Hypoxia induced protein conserved region 4HBT_2 PF13279.6 CRG83059.1 - 1.1e-07 32.3 0.0 1.8e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Cyclase PF04199.13 CRG83060.1 - 7.8e-13 48.8 0.0 9.5e-12 45.3 0.0 1.9 1 1 1 2 2 2 1 Putative cyclase DUF5490 PF17593.2 CRG83060.1 - 0.0042 17.1 0.1 0.01 15.8 0.1 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5490) Cupin_3 PF05899.12 CRG83060.1 - 0.033 13.9 0.0 0.063 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Fungal_trans_2 PF11951.8 CRG83061.1 - 9.2e-46 156.4 3.0 4.2e-24 85.1 1.3 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83061.1 - 2.1e-05 24.6 7.4 3.6e-05 23.8 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LSPR PF06049.12 CRG83061.1 - 0.16 11.9 0.6 0.65 10.1 0.6 2.1 1 0 0 1 1 1 0 Coagulation Factor V LSPD Repeat RHD3 PF05879.12 CRG83062.1 - 0 1057.8 0.0 0 1057.3 0.0 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MFS_1 PF07690.16 CRG83062.1 - 2e-42 145.4 46.8 2e-42 145.4 46.8 2.6 3 0 0 3 3 3 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG83062.1 - 4.4e-15 55.1 21.3 6.8e-15 54.5 21.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GBP PF02263.19 CRG83062.1 - 1.7e-07 30.8 0.2 4e-07 29.6 0.2 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 CRG83062.1 - 1.4e-05 25.2 0.0 3.2e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CRG83062.1 - 0.00038 20.5 0.0 0.00088 19.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 CRG83062.1 - 0.027 14.7 0.0 0.079 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 CRG83062.1 - 0.045 13.0 0.1 0.084 12.1 0.1 1.4 1 0 0 1 1 1 0 Septin DUF5442 PF17514.2 CRG83062.1 - 0.048 13.8 0.1 0.29 11.3 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5442) CDC27 PF09507.10 CRG83063.1 - 0.11 11.8 4.6 0.14 11.5 4.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 AA_permease_2 PF13520.6 CRG83064.1 - 1.4e-55 188.8 41.1 1.9e-55 188.4 41.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG83064.1 - 7.1e-27 94.1 41.4 1.2e-26 93.3 41.4 1.4 1 1 0 1 1 1 1 Amino acid permease Sec62 PF03839.16 CRG83064.1 - 0.089 12.3 2.1 0.26 10.7 2.1 1.8 1 0 0 1 1 1 0 Translocation protein Sec62 Acetyltransf_1 PF00583.25 CRG83065.1 - 4.1e-09 36.7 0.0 5e-09 36.4 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG83065.1 - 6e-08 33.0 0.0 9.1e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG83065.1 - 1.6e-07 31.3 0.0 2.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG83065.1 - 0.0088 16.1 0.1 0.17 12.0 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain HTH_54 PF18607.1 CRG83066.1 - 0.14 12.2 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 ParA helix turn helix domain TctB PF07331.11 CRG83066.1 - 0.88 9.8 11.8 0.39 11.0 5.4 2.4 2 1 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family RRM_1 PF00076.22 CRG83067.1 - 1.3e-58 194.7 0.0 1.2e-20 73.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG83067.1 - 7.9e-08 31.9 0.0 0.00016 21.3 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG83067.1 - 2.2e-07 30.7 0.0 0.003 17.4 0.0 2.8 2 1 0 2 2 2 2 Occluded RNA-recognition motif RRM_8 PF11835.8 CRG83067.1 - 0.00056 20.1 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 2 RRM-like domain RRM_7 PF16367.5 CRG83067.1 - 0.0016 18.5 0.1 1.1 9.4 0.0 3.5 3 1 0 3 3 3 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CRG83067.1 - 0.0034 17.4 0.0 6.5 6.8 0.0 3.4 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif Cas_Cas2CT1978 PF09707.10 CRG83067.1 - 0.011 15.8 0.0 1.5 8.9 0.0 2.4 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Limkain-b1 PF11608.8 CRG83067.1 - 0.088 12.9 0.1 39 4.4 0.0 3.3 3 0 0 3 3 3 0 Limkain b1 PRCC PF10253.9 CRG83068.1 - 6.3 7.5 7.7 9 7.0 7.7 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Arrestin_C PF02752.22 CRG83069.1 - 1.9e-22 80.2 0.5 1.8e-19 70.5 0.0 3.0 3 1 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CRG83069.1 - 3.7e-12 46.5 0.0 2.9e-06 27.4 0.0 3.0 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Acetyltransf_10 PF13673.7 CRG83070.1 - 2.7e-09 37.0 0.0 5.2e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG83070.1 - 4.2e-09 36.7 0.0 1.2e-08 35.2 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG83070.1 - 6.4e-09 36.1 0.0 1.5e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CRG83070.1 - 0.0015 18.5 0.0 0.0029 17.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein PGAP1 PF07819.13 CRG83070.1 - 0.0041 16.9 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Sporozoite_P67 PF05642.11 CRG83070.1 - 0.0059 14.8 3.3 0.0085 14.2 3.3 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen LCAT PF02450.15 CRG83070.1 - 0.013 14.7 0.0 0.033 13.4 0.0 1.6 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase Acetyltransf_CG PF14542.6 CRG83070.1 - 0.016 15.3 0.0 0.029 14.5 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CRG83070.1 - 0.025 14.7 0.0 1 9.5 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Abhydrolase_6 PF12697.7 CRG83070.1 - 0.1 13.2 8.4 0.41 11.2 8.2 2.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG83070.1 - 0.1 11.8 0.0 0.24 10.6 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 GNAT_acetyltran PF12746.7 CRG83070.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase Med3 PF11593.8 CRG83070.1 - 1.7 7.8 12.0 2.5 7.2 6.3 2.1 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Chs7 PF12271.8 CRG83071.1 - 1.7e-126 421.5 10.6 1.9e-126 421.3 10.6 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DUF3382 PF11862.8 CRG83071.1 - 0.0096 16.2 0.7 0.0096 16.2 0.7 2.6 1 1 2 3 3 3 1 Domain of unknown function (DUF3382) MFS_1 PF07690.16 CRG83072.1 - 1.8e-39 135.7 39.3 2.3e-39 135.3 38.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily RCC1 PF00415.18 CRG83073.1 - 2.4e-35 120.9 1.6 2.5e-08 34.4 0.1 6.4 6 1 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CRG83073.1 - 2.2e-30 103.8 21.2 2.8e-09 36.5 0.3 6.6 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Ribosomal_S6 PF01250.17 CRG83074.1 - 7.2e-24 83.9 0.0 9e-24 83.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 GCV_H PF01597.19 CRG83075.1 - 7.3e-40 135.7 0.8 8.6e-40 135.4 0.8 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein zf-RING_11 PF17123.5 CRG83076.1 - 0.0011 18.6 3.6 0.26 11.1 0.1 2.5 2 0 0 2 2 2 2 RING-like zinc finger DUF2921 PF11145.8 CRG83076.1 - 0.037 11.9 0.7 0.063 11.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) Cation_efflux PF01545.21 CRG83077.1 - 4.5e-13 49.4 11.9 5.9e-13 49.0 11.9 1.1 1 0 0 1 1 1 1 Cation efflux family COMPASS-Shg1 PF05205.12 CRG83079.1 - 4.8e-23 81.8 1.5 5.7e-23 81.6 0.0 1.9 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 Borrelia_P83 PF05262.11 CRG83079.1 - 0.051 12.1 19.1 0.092 11.2 19.1 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein PAP1 PF08601.10 CRG83079.1 - 0.095 12.4 1.2 0.17 11.6 1.2 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 Shisa PF13908.6 CRG83079.1 - 0.29 11.4 2.3 0.54 10.5 0.6 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF1129 PF06570.11 CRG83079.1 - 1.6 8.2 4.4 2.9 7.3 4.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) IF4E PF01652.18 CRG83080.1 - 4.7e-31 107.7 0.1 6.3e-31 107.3 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E 2Fe-2S_thioredx PF01257.19 CRG83080.1 - 0.041 13.7 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin DUF4598 PF15370.6 CRG83081.1 - 1.1e-31 109.6 7.1 1.1e-31 109.6 7.1 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4598) GDA1_CD39 PF01150.17 CRG83082.1 - 1e-99 334.1 0.0 1.4e-99 333.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family IF3_C PF00707.22 CRG83083.1 - 1.6e-08 34.4 0.2 2.5e-08 33.8 0.2 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 CRG83083.1 - 8.5e-08 32.4 0.0 2.1e-07 31.1 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.6 CRG83083.1 - 3e-05 23.8 0.2 5.2e-05 23.0 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial translation initiation factor S4 PF01479.25 CRG83083.1 - 0.059 13.1 0.1 0.22 11.3 0.0 2.1 2 0 0 2 2 2 0 S4 domain GTP_EFTU PF00009.27 CRG83084.1 - 1.1e-57 194.8 0.1 1.4e-57 194.4 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CRG83084.1 - 3.6e-22 78.8 0.0 8.7e-22 77.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CRG83084.1 - 1.9e-16 60.2 2.5 2.2e-16 60.0 0.9 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CRG83084.1 - 7.9e-06 25.9 0.1 1.6e-05 24.9 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG83084.1 - 0.0011 18.9 0.2 0.0041 17.1 0.1 2.0 1 1 1 2 2 2 1 RsgA GTPase cobW PF02492.19 CRG83084.1 - 0.023 14.3 0.5 0.2 11.2 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 CRG83084.1 - 0.026 14.3 0.2 6.5 6.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation bZIP_1 PF00170.21 CRG83085.1 - 0.0025 17.9 5.5 0.0041 17.2 5.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor GvpL_GvpF PF06386.11 CRG83085.1 - 0.069 13.1 1.5 0.1 12.5 1.5 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF MFS_1 PF07690.16 CRG83086.1 - 7.1e-18 64.7 55.4 6.5e-14 51.6 37.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily EPV_E5 PF08135.11 CRG83086.1 - 0.021 15.1 2.2 0.021 15.1 2.2 3.7 5 0 0 5 5 5 0 Major transforming protein E5 family RasGEF PF00617.19 CRG83087.1 - 1.8e-58 197.6 0.1 3.3e-58 196.8 0.0 1.5 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 CRG83087.1 - 1.6e-25 89.4 0.2 3.3e-25 88.3 0.2 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif DbpA PF03880.15 CRG83088.1 - 0.026 14.5 1.8 0.031 14.3 0.4 1.8 2 0 0 2 2 2 0 DbpA RNA binding domain FA_hydroxylase PF04116.13 CRG83089.1 - 3.2e-21 76.1 14.3 3.2e-21 76.1 14.3 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily GST_N_3 PF13417.6 CRG83090.1 - 3.7e-12 46.5 0.0 1.1e-11 45.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG83090.1 - 1.6e-11 44.3 0.0 3.7e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG83090.1 - 9.5e-06 25.6 0.0 1.8e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CRG83090.1 - 0.0011 19.2 0.0 0.023 15.0 0.0 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Peptidase_S15 PF02129.18 CRG83091.1 - 1.1e-36 126.8 0.1 1.7e-34 119.6 0.0 2.2 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 CRG83091.1 - 2.9e-27 96.1 0.0 3.9e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain PhyH PF05721.13 CRG83092.1 - 8.8e-07 29.4 0.0 1.9e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 CRG83092.1 - 5.6e-06 25.4 0.7 0.04 12.7 0.0 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.6 CRG83092.1 - 0.028 15.3 0.0 0.067 14.1 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 CRG83092.1 - 0.075 13.5 0.0 0.18 12.2 0.0 1.7 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase MFS_1 PF07690.16 CRG83093.1 - 1.3e-21 76.9 33.0 1.5e-20 73.5 29.8 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83093.1 - 2e-13 50.0 7.9 2e-13 50.0 7.9 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter Ndc1_Nup PF09531.10 CRG83093.1 - 0.0088 14.8 2.5 0.015 14.1 2.5 1.3 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup DUF4191 PF13829.6 CRG83093.1 - 0.12 11.6 0.2 0.12 11.6 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4191) Fungal_trans PF04082.18 CRG83094.1 - 2.1e-07 30.3 0.1 3.9e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83094.1 - 1.5e-06 28.2 10.7 3.3e-06 27.1 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SMI1_KNR4 PF09346.10 CRG83095.1 - 2.8e-07 31.0 0.1 1.1e-06 29.1 0.0 2.1 2 1 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) SUKH_6 PF14568.6 CRG83095.1 - 0.00037 20.9 0.0 0.0019 18.6 0.0 2.4 1 1 0 1 1 1 1 SMI1-KNR4 cell-wall SUKH_5 PF14567.6 CRG83095.1 - 0.014 15.1 0.0 0.079 12.7 0.0 2.2 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall Pyr_redox_2 PF07992.14 CRG83096.1 - 2.5e-52 178.0 0.0 3.1e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG83096.1 - 9.4e-12 45.3 0.0 2.9e-10 40.6 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG83096.1 - 0.0017 17.6 0.0 1.2 8.3 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG83096.1 - 0.15 12.3 0.0 19 5.6 0.0 2.7 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain Cyclin PF08613.11 CRG83097.1 - 9.3e-13 48.9 0.0 1.4e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CRG83097.1 - 0.0091 15.7 0.1 0.015 15.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Dynamin_N PF00350.23 CRG83098.1 - 3e-45 154.3 0.0 5.7e-45 153.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CRG83098.1 - 8.8e-15 54.7 0.0 3.7e-12 46.1 0.0 2.6 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 CRG83098.1 - 2.9e-05 24.1 0.0 0.00011 22.3 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG83098.1 - 0.039 14.3 0.3 0.2 12.0 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 CRG83098.1 - 0.059 13.6 0.2 0.67 10.2 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 CRG83098.1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CRG83098.1 - 0.07 12.8 0.1 0.21 11.2 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain GATase_4 PF13230.6 CRG83099.1 - 1.3e-13 50.5 0.0 1.2e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 CRG83099.1 - 3.1e-08 33.9 0.0 6.3e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain PIG-Y PF15159.6 CRG83100.1 - 6.5e-22 78.2 8.3 1e-21 77.6 8.3 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y SUIM_assoc PF16619.5 CRG83100.1 - 1.2 9.3 9.2 3.2 7.9 9.2 1.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF1218 PF06749.12 CRG83100.1 - 1.4 9.5 4.5 22 5.6 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Ribosomal_L27A PF00828.19 CRG83101.1 - 2.6e-28 99.2 0.7 3.6e-28 98.8 0.7 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Pkinase PF00069.25 CRG83102.1 - 3.4e-44 151.2 0.0 4.4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83102.1 - 4.3e-25 88.5 0.0 4.3e-23 81.9 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG83102.1 - 0.025 13.4 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase SH3_1 PF00018.28 CRG83103.1 - 5.6e-06 25.9 0.0 1.2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG83103.1 - 0.0058 16.5 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_16 PF18348.1 CRG83103.1 - 0.056 13.2 0.2 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain SHE3 PF17078.5 CRG83103.1 - 0.19 11.4 2.4 0.38 10.4 1.9 1.7 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Rick_17kDa_Anti PF05433.15 CRG83104.1 - 3.8e-05 23.5 13.8 8.5e-05 22.3 13.8 1.6 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 CRG83104.1 - 0.00083 19.3 10.8 0.0027 17.7 10.8 1.9 1 0 0 1 1 1 1 Glycine zipper IMUP PF15761.5 CRG83104.1 - 0.063 14.0 19.2 0.14 12.8 19.2 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 CRG83104.1 - 0.083 12.5 15.8 0.12 12.0 15.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Gly-zipper_YMGG PF13441.6 CRG83104.1 - 0.59 9.9 16.6 0.055 13.2 11.5 2.0 2 0 0 2 2 2 0 YMGG-like Gly-zipper DUF755 PF05501.11 CRG83104.1 - 0.6 10.4 24.2 0.91 9.8 24.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) TraT PF05818.12 CRG83104.1 - 3 7.5 9.7 7.5 6.2 9.7 1.7 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein GREB1 PF15782.5 CRG83105.1 - 0.31 8.1 2.9 0.33 8.0 2.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PPP4R2 PF09184.11 CRG83105.1 - 0.5 9.9 4.1 0.62 9.6 4.1 1.1 1 0 0 1 1 1 0 PPP4R2 Hydin_ADK PF17213.3 CRG83105.1 - 1.1 9.5 11.1 2 8.7 11.1 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SOG2 PF10428.9 CRG83105.1 - 1.2 8.3 16.8 1.5 7.9 16.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 CRG83105.1 - 1.5 7.3 7.7 1.9 7.0 7.7 1.0 1 0 0 1 1 1 0 Macoilin family PQ-loop PF04193.14 CRG83106.1 - 6.5e-37 125.1 10.5 3.8e-18 65.0 0.8 2.6 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 CRG83106.1 - 0.27 11.3 0.1 0.27 11.3 0.1 2.4 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange Aminotran_1_2 PF00155.21 CRG83107.1 - 1.6e-63 215.1 0.0 2.1e-63 214.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CRG83107.1 - 0.022 13.7 0.0 0.032 13.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Beta_elim_lyase PF01212.21 CRG83107.1 - 0.028 13.7 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Tmemb_18A PF09771.9 CRG83107.1 - 0.098 13.1 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 188 AMP-binding PF00501.28 CRG83108.1 - 1.2e-33 116.4 0.0 2.4e-33 115.4 0.0 1.4 1 1 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CRG83108.1 - 3.4e-10 39.7 0.4 7.2e-10 38.6 0.4 1.6 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_M16_C PF05193.21 CRG83109.1 - 3e-54 183.8 0.0 6.2e-54 182.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CRG83109.1 - 6.1e-44 149.6 0.0 9.2e-42 142.5 0.0 2.2 2 0 0 2 2 2 2 Insulinase (Peptidase family M16) TRPM_tetra PF16519.5 CRG83109.1 - 1.3 9.1 6.0 0.31 11.2 1.7 2.1 2 0 0 2 2 2 0 Tetramerisation domain of TRPM Tom22 PF04281.13 CRG83110.1 - 5.2e-47 159.1 2.2 5.8e-41 139.5 0.2 2.1 2 0 0 2 2 2 2 Mitochondrial import receptor subunit Tom22 DUF4211 PF13926.6 CRG83111.1 - 9.6e-40 136.0 0.0 9.6e-40 136.0 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) DUF4449 PF14613.6 CRG83112.1 - 1.5e-58 197.5 6.1 1.5e-58 197.5 6.1 3.3 2 1 2 4 4 4 1 Protein of unknown function (DUF4449) Prp18 PF02840.15 CRG83112.1 - 0.001 19.1 8.0 0.011 15.7 0.1 3.6 2 1 1 3 3 3 2 Prp18 domain ACBP PF00887.19 CRG83112.1 - 0.082 13.1 1.4 0.56 10.5 0.0 2.8 2 0 0 2 2 2 0 Acyl CoA binding protein DUF357 PF04010.13 CRG83112.1 - 0.64 10.1 3.9 1.9 8.6 0.3 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF357) PTPLA PF04387.14 CRG83113.1 - 1.7e-57 193.7 7.4 2.5e-57 193.2 7.4 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Adaptin_binding PF10199.9 CRG83114.1 - 8.7e-18 65.1 4.2 1.3e-17 64.5 1.5 2.2 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 CRA PF06589.11 CRG83114.1 - 1.8 8.7 5.0 6.8 6.8 1.5 2.5 2 1 0 2 2 2 0 Circumsporozoite-related antigen (CRA) LSM PF01423.22 CRG83115.1 - 1.7e-15 56.4 0.2 2.3e-15 56.0 0.2 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CRG83115.1 - 0.091 12.9 0.1 0.16 12.1 0.1 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain PGP_phosphatase PF09419.10 CRG83116.1 - 4.2e-53 179.4 0.0 5e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 CRG83116.1 - 4.8e-06 26.5 0.0 8.5e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 CRG83116.1 - 0.17 12.1 0.1 26 5.0 0.3 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Homeodomain PF00046.29 CRG83117.1 - 2e-19 69.2 4.2 5.3e-19 67.8 4.2 1.8 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CRG83117.1 - 0.0014 18.5 0.5 0.0014 18.5 0.5 2.1 2 0 0 2 2 2 1 Homeobox KN domain PhoLip_ATPase_C PF16212.5 CRG83118.1 - 5.7e-74 249.0 22.3 5.7e-74 249.0 22.3 2.5 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CRG83118.1 - 1.3e-22 79.2 7.7 4e-22 77.7 2.0 2.7 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CRG83118.1 - 1.6e-12 47.3 0.3 1.3e-11 44.4 0.0 2.6 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG83118.1 - 2e-12 47.9 1.7 1.6e-05 25.3 0.2 3.5 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CRG83118.1 - 2.7e-10 40.1 0.2 2.7e-10 40.1 0.2 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CRG83118.1 - 0.0044 16.8 0.0 0.013 15.3 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LRR19-TM PF15176.6 CRG83118.1 - 7.8 6.6 8.7 1.4 9.0 0.2 3.2 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain SRP_TPR_like PF17004.5 CRG83120.1 - 7.8e-18 64.6 3.9 1.9e-17 63.4 2.4 2.4 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 CRG83120.1 - 7.2e-17 61.6 5.6 7.2e-17 61.6 5.6 2.7 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 CRG83120.1 - 0.00011 22.6 12.8 0.069 13.7 0.0 5.7 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG83120.1 - 0.0082 16.9 16.2 40 5.4 0.0 8.3 6 2 2 8 8 8 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG83120.1 - 0.078 13.6 6.0 44 5.1 0.1 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat UPF0175 PF03683.13 CRG83120.1 - 0.16 11.7 2.2 0.54 10.0 0.2 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0175) ANAPC3 PF12895.7 CRG83120.1 - 0.82 9.9 9.5 19 5.6 0.4 4.4 3 2 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 CRG83120.1 - 7.7 6.9 16.2 48 4.4 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat DLH PF01738.18 CRG83121.1 - 2.6e-15 56.6 0.1 4e-15 56.0 0.1 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Fringe PF02434.16 CRG83121.1 - 7e-10 38.8 0.1 1.3e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.12 CRG83121.1 - 3.9e-09 36.3 0.1 6.7e-09 35.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Glyco_hydro_31 PF01055.26 CRG83122.1 - 1.8e-149 498.7 6.3 2.3e-149 498.4 6.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG83122.1 - 2.6e-33 114.7 0.0 4.8e-33 113.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG83122.1 - 1.3e-05 25.4 1.1 9.2e-05 22.7 1.1 2.6 1 1 0 1 1 1 1 Galactose mutarotase-like GHL15 PF14885.6 CRG83122.1 - 0.028 14.4 2.4 0.061 13.3 2.4 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 Fungal_trans PF04082.18 CRG83123.1 - 6.5e-13 48.3 0.1 6.5e-13 48.3 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83123.1 - 1.7e-08 34.4 12.7 1.7e-08 34.4 12.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Anticodon_1 PF08264.13 CRG83123.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA p450 PF00067.22 CRG83124.1 - 1.8e-05 23.7 0.0 2.2e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_15 PF00723.21 CRG83125.1 - 4.4e-98 329.0 0.0 5.9e-98 328.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 CRG83125.1 - 8.7e-27 92.9 0.2 1.8e-26 91.9 0.2 1.6 1 0 0 1 1 1 1 Starch binding domain Alpha-amylase PF00128.24 CRG83126.1 - 3.1e-65 221.0 2.5 5e-65 220.3 2.5 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CRG83126.1 - 8.1e-30 102.9 0.3 1.7e-29 101.9 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Homeobox_KN PF05920.11 CRG83127.1 - 7.6e-21 73.7 0.2 7.6e-21 73.7 0.2 2.1 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 CRG83127.1 - 1.4e-06 28.1 0.1 2.9e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Homeodomain Peptidase_M66 PF10462.9 CRG83127.1 - 9.3 5.1 9.7 16 4.3 9.7 1.3 1 0 0 1 1 1 0 Peptidase M66 FAD_binding_1 PF00667.20 CRG83128.1 - 8e-45 153.1 0.0 1.2e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CRG83128.1 - 2.7e-09 37.6 0.0 9e-09 36.0 0.0 2.0 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Glyco_hydro_47 PF01532.20 CRG83129.1 - 1.4e-184 614.3 0.1 1.6e-184 614.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Med20 PF08612.11 CRG83130.1 - 9.9e-74 247.5 0.0 1.1e-73 247.3 0.0 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex EF-hand_1 PF00036.32 CRG83131.1 - 1.3e-41 137.0 11.6 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CRG83131.1 - 3.6e-36 123.4 5.3 3.9e-19 68.9 2.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CRG83131.1 - 1.9e-34 117.3 11.5 2.4e-15 56.1 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 CRG83131.1 - 3.8e-30 101.2 8.5 7.1e-09 34.9 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CRG83131.1 - 6.8e-26 88.6 9.8 4.7e-06 25.9 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 CRG83131.1 - 1.4e-16 60.5 0.4 2.3e-09 37.4 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 CRG83131.1 - 6.8e-10 38.8 1.6 0.00078 19.4 0.3 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 CRG83131.1 - 5.9e-09 36.2 0.2 0.0016 18.7 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 CRG83131.1 - 1e-06 28.6 0.1 0.008 16.2 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 CRG83131.1 - 6.4e-06 26.2 1.6 2.3e-05 24.4 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 CRG83131.1 - 9.4e-05 23.2 0.2 0.0025 18.6 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 CRG83131.1 - 0.00013 21.9 0.3 0.35 10.8 0.0 2.2 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 CRG83131.1 - 0.00059 19.8 1.6 0.52 10.2 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein RNA_pol_Rpb4 PF03874.16 CRG83131.1 - 0.00062 20.1 0.7 0.66 10.3 0.1 2.6 2 1 1 3 3 3 2 RNA polymerase Rpb4 Dockerin_1 PF00404.18 CRG83131.1 - 0.0053 16.9 7.0 0.38 11.0 0.8 2.9 1 1 2 3 3 3 2 Dockerin type I domain DUF5580 PF17743.1 CRG83131.1 - 0.0057 15.3 0.0 0.0058 15.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) SurA_N_2 PF13623.6 CRG83131.1 - 0.0084 16.0 0.7 0.32 10.9 0.1 2.2 1 1 1 2 2 2 1 SurA N-terminal domain EF-hand_14 PF17959.1 CRG83131.1 - 0.012 16.0 0.5 6.2 7.2 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain Poly_export PF02563.16 CRG83131.1 - 0.023 14.9 0.0 0.18 12.0 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein RuvA_C PF07499.13 CRG83131.1 - 0.058 13.9 0.1 8.5 6.9 0.0 3.0 3 0 0 3 3 3 0 RuvA, C-terminal domain dCache_2 PF08269.11 CRG83131.1 - 0.061 12.5 0.1 1 8.5 0.1 2.1 1 1 1 2 2 2 0 Cache domain MotA_activ PF09114.10 CRG83131.1 - 0.061 13.5 0.3 0.91 9.7 0.0 2.3 1 1 0 2 2 2 0 Transcription factor MotA, activation domain DUF4497 PF14924.6 CRG83131.1 - 0.092 13.2 0.0 8.7 6.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4497) RloB PF13707.6 CRG83131.1 - 0.11 12.7 1.3 0.72 10.0 0.2 2.1 1 1 1 2 2 2 0 RloB-like protein DUF5132 PF17195.4 CRG83131.1 - 0.16 12.1 0.5 21 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) SNARE PF05739.19 CRG83132.1 - 2.7e-16 59.3 1.7 5.6e-16 58.3 1.7 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 CRG83132.1 - 2.3e-06 27.4 4.9 2.3e-06 27.4 4.9 1.6 2 0 0 2 2 2 1 Syntaxin DUF948 PF06103.11 CRG83132.1 - 0.018 15.3 2.4 11 6.3 0.1 3.6 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1818 PF08848.11 CRG83132.1 - 0.067 13.3 0.1 0.13 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1818) BBP1_C PF15272.6 CRG83132.1 - 0.29 10.9 6.5 3.3 7.5 0.5 2.4 1 1 1 2 2 2 0 Spindle pole body component BBP1, C-terminal MCPsignal PF00015.21 CRG83132.1 - 0.48 10.2 6.9 0.11 12.3 1.0 2.3 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain MutS_III PF05192.18 CRG83132.1 - 0.83 9.8 5.8 1.5 9.0 5.7 1.5 1 1 0 1 1 1 0 MutS domain III KxDL PF10241.9 CRG83132.1 - 2 8.7 9.4 1.4 9.2 1.1 3.0 3 1 0 3 3 3 0 Uncharacterized conserved protein CTD_bind PF04818.13 CRG83133.1 - 4e-18 66.0 0.2 1.2e-17 64.5 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CREPT PF16566.5 CRG83133.1 - 0.012 15.8 0.1 0.031 14.5 0.1 1.6 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour CTK3 PF12243.8 CRG83133.1 - 0.02 14.9 0.1 0.046 13.7 0.1 1.5 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 SKA2 PF16740.5 CRG83133.1 - 0.048 13.4 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DnaG_DnaB_bind PF08278.11 CRG83133.1 - 0.093 13.3 1.9 0.72 10.5 0.6 2.4 2 1 0 2 2 2 0 DNA primase DnaG DnaB-binding Clathrin_lg_ch PF01086.17 CRG83134.1 - 2.3e-74 250.3 1.9 2.6e-74 250.2 1.9 1.0 1 0 0 1 1 1 1 Clathrin light chain CDC37_N PF03234.14 CRG83135.1 - 4.2e-50 170.0 1.4 4.2e-50 170.0 1.4 2.7 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 CRG83135.1 - 3.3e-42 143.1 0.0 9.7e-42 141.6 0.0 1.8 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 CRG83135.1 - 3.2e-33 113.8 1.7 1.2e-32 111.9 0.8 2.5 2 0 0 2 2 2 1 Cdc37 C terminal domain DUF3246 PF11596.8 CRG83135.1 - 0.036 13.5 2.7 0.06 12.8 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) ABC_membrane PF00664.23 CRG83136.1 - 3.3e-51 174.6 9.5 4.2e-51 174.2 9.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CRG83136.1 - 5.3e-36 124.1 0.0 1.4e-35 122.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CRG83136.1 - 2.7e-06 27.0 0.0 0.00021 20.8 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG83136.1 - 0.00052 20.4 0.0 0.0015 19.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 CRG83136.1 - 0.0016 18.2 0.2 0.45 10.2 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CRG83136.1 - 0.0026 18.0 0.0 0.016 15.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CRG83136.1 - 0.009 15.7 0.0 0.025 14.3 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 CRG83136.1 - 0.0098 16.3 0.0 0.081 13.3 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 CRG83136.1 - 0.034 13.9 0.0 0.31 10.7 0.0 2.3 2 1 0 2 2 2 0 IstB-like ATP binding protein AAA_30 PF13604.6 CRG83136.1 - 0.045 13.5 0.0 0.15 11.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG83136.1 - 0.073 13.1 0.0 0.47 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 CRG83136.1 - 0.088 12.9 0.6 0.25 11.4 0.1 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain Sigma54_activ_2 PF14532.6 CRG83136.1 - 0.14 12.3 0.1 1.5 8.9 0.0 2.5 3 0 0 3 3 2 0 Sigma-54 interaction domain SbcCD_C PF13558.6 CRG83136.1 - 5.1 7.4 5.6 2.5 8.4 0.5 3.0 2 1 0 2 2 1 0 Putative exonuclease SbcCD, C subunit Amidase PF01425.21 CRG83138.1 - 1.4e-49 169.3 0.3 1.9e-47 162.3 0.3 2.4 1 1 0 1 1 1 1 Amidase Nucleoside_tran PF01733.18 CRG83139.1 - 2.6e-47 161.7 10.0 2.6e-47 161.7 10.0 2.2 2 1 0 2 2 2 1 Nucleoside transporter MFS_1 PF07690.16 CRG83139.1 - 3.3e-05 23.0 25.4 0.018 14.0 16.7 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF5408 PF17402.2 CRG83139.1 - 0.0056 16.5 0.1 4.2 7.3 0.0 2.7 2 0 0 2 2 2 2 Family of unknown function (DUF5408) Haspin_kinase PF12330.8 CRG83141.1 - 9.4e-39 133.4 0.0 1.9e-38 132.4 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Methyltransf_31 PF13847.6 CRG83143.1 - 3.5e-29 101.6 0.0 5.3e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83143.1 - 4e-25 88.3 0.0 6.9e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83143.1 - 7.5e-23 81.1 0.0 1.4e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG83143.1 - 3.5e-18 65.8 0.0 5.2e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG83143.1 - 1.9e-16 60.6 0.0 2.8e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG83143.1 - 6.1e-16 58.7 0.0 9.5e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CRG83143.1 - 3.5e-09 36.7 0.0 5e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 CRG83143.1 - 1.5e-08 34.4 0.0 2.5e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 CRG83143.1 - 4.4e-08 32.8 0.0 7.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 CRG83143.1 - 1.4e-07 31.3 0.0 2.1e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 CRG83143.1 - 1.3e-05 24.4 0.1 3.5e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) CMAS PF02353.20 CRG83143.1 - 0.00033 20.0 0.0 0.00045 19.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DREV PF05219.12 CRG83143.1 - 0.00053 19.2 0.0 0.00076 18.7 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_18 PF12847.7 CRG83143.1 - 0.00065 19.7 0.0 0.00098 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CRG83143.1 - 0.0015 18.0 0.0 0.0021 17.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) NodS PF05401.11 CRG83143.1 - 0.011 15.4 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 CRG83143.1 - 0.04 13.9 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 CRG83143.1 - 0.042 13.2 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G RrnaAD PF00398.20 CRG83143.1 - 0.051 12.6 0.0 0.069 12.2 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_29 PF03141.16 CRG83143.1 - 0.054 12.0 0.0 0.19 10.2 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltr_RsmB-F PF01189.17 CRG83143.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DOT1 PF08123.13 CRG83143.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 tRNA_U5-meth_tr PF05958.11 CRG83143.1 - 0.18 10.8 0.0 0.25 10.3 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase COX7a PF02238.15 CRG83144.1 - 5.5e-24 84.3 4.0 7.3e-24 83.9 4.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Nitroreductase PF00881.24 CRG83146.1 - 5.4e-12 46.1 0.0 6.2e-12 45.9 0.0 1.0 1 0 0 1 1 1 1 Nitroreductase family Fungal_trans PF04082.18 CRG83148.1 - 2.4e-12 46.4 0.1 4.2e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83148.1 - 1.5e-09 37.8 9.1 2.8e-09 36.9 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_5 PF00266.19 CRG83149.1 - 2.8e-05 23.2 0.0 0.00064 18.8 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class-V IDO PF01231.18 CRG83150.1 - 3.5e-154 513.8 0.0 4.4e-154 513.4 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase PAP1 PF08601.10 CRG83150.1 - 0.098 12.4 2.6 0.14 11.9 2.6 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Herpes_pp85 PF04637.12 CRG83150.1 - 0.14 10.6 6.2 0.19 10.1 6.2 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) DUF1682 PF07946.14 CRG83151.1 - 3.7e-117 391.2 0.1 4.2e-117 391.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Ins_P5_2-kin PF06090.12 CRG83152.1 - 3.6e-45 154.8 0.0 1.5e-44 152.8 0.0 1.9 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase YEATS PF03366.16 CRG83154.1 - 5.2e-37 125.7 2.2 8e-37 125.1 2.2 1.3 1 0 0 1 1 1 1 YEATS family M16C_assoc PF08367.11 CRG83154.1 - 0.048 12.8 1.0 0.068 12.3 1.0 1.2 1 0 0 1 1 1 0 Peptidase M16C associated Bcr-Abl_Oligo PF09036.10 CRG83154.1 - 0.086 12.9 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain DUF2752 PF10825.8 CRG83154.1 - 0.21 11.7 0.4 0.4 10.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Epimerase PF01370.21 CRG83155.1 - 2.2e-06 27.3 0.0 7.3e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG83155.1 - 1.8e-05 24.7 0.0 0.00049 20.0 0.0 2.6 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG83155.1 - 0.00075 18.6 0.0 0.0032 16.5 0.0 2.0 2 1 1 3 3 3 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG83155.1 - 0.004 16.4 0.1 0.036 13.2 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein RmlD_sub_bind PF04321.17 CRG83155.1 - 0.0048 16.0 0.0 0.049 12.7 0.0 2.2 2 0 0 2 2 2 1 RmlD substrate binding domain adh_short PF00106.25 CRG83155.1 - 0.059 12.8 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase SYF2 PF08231.12 CRG83156.1 - 2.8e-58 196.8 13.4 2.8e-58 196.8 13.4 1.5 2 0 0 2 2 2 1 SYF2 splicing factor Arteri_nsp7a PF16749.5 CRG83157.1 - 0.063 13.5 0.0 0.72 10.0 0.0 2.3 2 0 0 2 2 2 0 Arterivirus nonstructural protein 7 alpha Velvet PF11754.8 CRG83158.1 - 6.2e-55 186.8 0.1 1.3e-53 182.5 0.1 2.2 1 1 0 1 1 1 1 Velvet factor TPR_19 PF14559.6 CRG83159.1 - 6.5e-06 26.6 0.5 0.061 13.8 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 CRG83159.1 - 7.2e-06 26.4 2.6 0.0069 17.1 0.0 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 CRG83159.1 - 0.0021 18.6 0.8 0.016 15.8 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG83159.1 - 0.01 16.1 0.1 0.057 13.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 CRG83159.1 - 0.025 14.7 0.0 0.025 14.7 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CRG83159.1 - 0.029 14.2 0.2 0.23 11.4 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG83159.1 - 0.05 14.2 3.5 0.059 14.0 0.0 2.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG83159.1 - 0.075 13.7 1.1 2.3 9.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CRG83159.1 - 0.3 11.2 5.7 0.38 10.9 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 CRG83159.1 - 0.36 11.2 0.0 0.36 11.2 0.0 3.4 5 0 0 5 5 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG83159.1 - 0.51 10.6 3.5 3.8 7.8 0.0 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CRG83159.1 - 2.4 8.1 5.1 1.4 8.8 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyoxalase PF00903.25 CRG83160.1 - 5.9e-11 42.7 0.0 1.1e-10 41.8 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CRG83160.1 - 3.5e-06 27.3 0.0 4.4e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CRG83160.1 - 0.00033 20.8 0.0 0.00051 20.2 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CRG83160.1 - 0.0031 17.4 0.0 0.089 12.7 0.0 2.1 2 0 0 2 2 2 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 CRG83160.1 - 0.039 14.7 0.0 0.12 13.1 0.0 1.8 1 1 0 1 1 1 0 Glyoxalase-like domain Ribosomal_L12 PF00542.19 CRG83161.1 - 3.3e-19 69.0 3.7 5.7e-18 65.0 3.3 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 CRG83161.1 - 7.1e-14 51.3 5.1 2.1e-13 49.8 2.2 3.1 2 1 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain Bac_DNA_binding PF00216.21 CRG83161.1 - 0.059 13.6 1.2 0.088 13.0 0.2 1.7 2 0 0 2 2 2 0 Bacterial DNA-binding protein SpoVIF PF14069.6 CRG83161.1 - 0.067 13.0 1.5 0.29 11.0 0.5 2.2 2 1 0 2 2 2 0 Stage VI sporulation protein F DAHP_snth_FXD PF18152.1 CRG83161.1 - 0.13 12.1 0.1 0.39 10.6 0.1 1.8 1 0 0 1 1 1 0 DAHP synthase ferredoxin-like domain PH_10 PF15411.6 CRG83162.1 - 1.3e-26 93.3 0.2 2.5e-26 92.3 0.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 CRG83162.1 - 1.9e-13 51.1 0.0 3.6e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 CRG83162.1 - 7.8e-09 35.7 0.1 1.1e-07 31.9 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain zf-RING_2 PF13639.6 CRG83162.1 - 0.00065 20.0 5.2 0.0015 18.9 5.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CRG83162.1 - 0.003 17.5 5.9 0.0058 16.6 5.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CRG83162.1 - 0.0052 17.1 2.8 0.012 15.9 2.8 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CRG83162.1 - 0.012 15.5 5.9 0.026 14.4 5.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG83162.1 - 0.015 15.1 4.9 0.038 13.8 4.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.29 CRG83162.1 - 0.038 14.5 0.5 0.14 12.6 0.1 2.1 2 0 0 2 2 2 0 PH domain zf-RING-like PF08746.11 CRG83162.1 - 0.047 14.0 4.9 0.099 13.0 4.9 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_3 PF13920.6 CRG83162.1 - 0.069 13.0 2.2 0.16 11.8 2.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CRG83162.1 - 0.089 12.4 8.6 0.013 15.1 3.2 2.1 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-UDP PF14569.6 CRG83162.1 - 0.32 11.2 0.9 0.58 10.3 0.9 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3H2C3 PF17122.5 CRG83162.1 - 0.78 9.8 6.4 1.9 8.6 6.4 1.7 1 0 0 1 1 1 0 Zinc-finger p450 PF00067.22 CRG83163.1 - 9.1e-57 192.8 0.0 1.1e-56 192.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 COesterase PF00135.28 CRG83165.1 - 4.2e-83 280.0 0.0 5.2e-83 279.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG83165.1 - 0.0015 18.4 0.4 0.004 17.1 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG83165.1 - 0.0068 15.9 0.4 0.016 14.7 0.4 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family E1_dh PF00676.20 CRG83166.1 - 1.1e-112 375.9 0.2 1.3e-112 375.6 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CRG83166.1 - 0.00015 21.1 0.1 0.0003 20.1 0.1 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase SseC PF04888.12 CRG83167.1 - 0.015 14.9 4.5 0.025 14.2 4.5 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DUF3439 PF11921.8 CRG83167.1 - 0.045 13.7 5.4 0.097 12.6 5.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MIF4G_like_2 PF09090.11 CRG83167.1 - 1.2 8.5 6.2 4.6 6.6 0.2 2.8 2 1 0 2 2 2 0 MIF4G like S4 PF01479.25 CRG83168.1 - 6.4e-15 54.6 0.0 1.3e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain S4_2 PF13275.6 CRG83168.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 S4 domain SPG4 PF17325.2 CRG83168.1 - 0.66 11.1 11.1 0.18 12.9 1.3 2.5 2 0 0 2 2 2 0 Stationary phase protein 4 OATP PF03137.20 CRG83168.1 - 2.1 6.5 3.4 15 3.7 2.3 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF3636 PF12331.8 CRG83169.1 - 2.6e-39 134.4 0.1 4.9e-39 133.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) LCD1 PF09798.9 CRG83169.1 - 3.1e-05 22.7 8.9 0.0069 15.0 0.4 3.0 2 1 1 3 3 3 2 DNA damage checkpoint protein Golgin_A5 PF09787.9 CRG83169.1 - 0.076 12.5 9.1 0.17 11.3 9.1 1.6 1 0 0 1 1 1 0 Golgin subfamily A member 5 UPF0242 PF06785.11 CRG83169.1 - 0.45 10.6 5.6 1.2 9.2 5.6 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 CRG83169.1 - 2.8 8.6 5.2 6.3 7.5 0.8 2.8 1 1 1 2 2 2 0 Initiation control protein YabA CTP_transf_1 PF01148.20 CRG83170.1 - 4.5e-80 269.2 24.3 6.3e-80 268.8 24.3 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Cyclin_N PF00134.23 CRG83171.1 - 7.1e-07 29.0 0.1 8.4e-06 25.5 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain GST_N_3 PF13417.6 CRG83172.1 - 5.4e-19 68.4 0.2 9.8e-19 67.6 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG83172.1 - 5.6e-19 68.2 0.4 1.8e-18 66.6 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG83172.1 - 1e-10 41.8 0.2 2e-10 40.9 0.2 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG83172.1 - 2.1e-05 24.5 0.7 4.8e-05 23.3 0.7 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG83172.1 - 0.0012 19.0 0.0 0.0029 17.8 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG83172.1 - 0.013 15.8 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CRG83172.1 - 0.016 15.8 0.0 0.063 13.9 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG83172.1 - 0.057 14.2 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain Fructosamin_kin PF03881.14 CRG83173.1 - 1e-78 264.5 0.0 1.3e-78 264.2 0.0 1.0 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 CRG83173.1 - 0.0014 18.6 0.0 0.0026 17.7 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ge1_WD40 PF16529.5 CRG83174.1 - 0.00012 21.1 0.0 0.00022 20.3 0.0 1.3 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DciA PF05258.12 CRG83174.1 - 0.079 13.4 0.2 0.36 11.2 0.1 2.3 2 0 0 2 2 2 0 Dna[CI] antecedent, DciA Tup_N PF08581.10 CRG83174.1 - 0.38 11.1 2.1 1.1 9.6 2.1 1.8 1 0 0 1 1 1 0 Tup N-terminal TRAF_BIRC3_bd PF16673.5 CRG83174.1 - 0.65 9.8 3.2 0.49 10.2 0.9 2.0 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF445 PF04286.12 CRG83174.1 - 5.7 6.6 16.5 0.18 11.6 6.8 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF445) MCD PF05292.11 CRG83174.1 - 9.1 5.8 8.4 0.7 9.4 1.5 2.6 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain dCMP_cyt_deam_1 PF00383.23 CRG83175.1 - 2.7e-07 30.4 0.0 2.8e-06 27.1 0.0 2.5 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region An_peroxidase PF03098.15 CRG83176.1 - 4.9e-74 249.8 0.0 7.3e-74 249.2 0.0 1.2 1 0 0 1 1 1 1 Animal haem peroxidase p450 PF00067.22 CRG83176.1 - 8.1e-12 44.6 0.0 3.9e-08 32.5 0.0 2.3 2 0 0 2 2 2 2 Cytochrome P450 Dynamin_N PF00350.23 CRG83177.1 - 3.4e-31 108.6 0.1 1e-30 107.0 0.0 1.9 2 0 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 CRG83177.1 - 9.9e-29 100.4 0.3 2.1e-28 99.4 0.3 1.5 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 CRG83177.1 - 0.00075 19.6 0.0 0.011 15.8 0.0 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 CRG83177.1 - 0.093 12.9 0.6 1.4 9.1 0.3 2.8 2 0 0 2 2 2 0 Dynamin GTPase effector domain FeoB_N PF02421.18 CRG83177.1 - 0.14 11.7 0.1 1.8 8.1 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B UPA PF17217.3 CRG83177.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 UPA domain IZUMO PF15005.6 CRG83177.1 - 4.8 7.7 6.0 2.2 8.8 0.9 2.8 2 2 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Cyclin PF08613.11 CRG83178.1 - 9.4e-33 113.9 0.8 2.4e-32 112.6 0.0 2.1 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CRG83178.1 - 0.00026 20.8 0.0 0.00044 20.0 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain PAT1 PF09770.9 CRG83178.1 - 0.33 9.2 4.1 0.42 8.8 4.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Arm PF00514.23 CRG83179.1 - 5.5e-10 38.9 3.9 0.0014 18.6 0.2 7.4 8 0 0 8 8 8 3 Armadillo/beta-catenin-like repeat gp45-slide_C PF09116.10 CRG83179.1 - 0.11 12.5 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal HEAT PF02985.22 CRG83179.1 - 5.1 7.6 9.8 50 4.6 0.0 6.4 7 0 0 7 7 7 0 HEAT repeat BC10 PF06726.12 CRG83181.1 - 2.4e-12 46.9 4.6 2.4e-12 46.9 4.6 1.8 2 0 0 2 2 2 1 Bladder cancer-related protein BC10 VKOR PF07884.14 CRG83181.1 - 0.013 15.7 1.0 0.033 14.4 1.0 1.6 1 0 0 1 1 1 0 Vitamin K epoxide reductase family DLH PF01738.18 CRG83182.1 - 2.2e-26 92.8 0.0 3.4e-26 92.2 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family APH PF01636.23 CRG83182.1 - 2.8e-05 24.1 3.0 0.0001 22.3 1.8 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase PF00069.25 CRG83182.1 - 0.00012 21.6 0.1 0.00022 20.7 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 CRG83182.1 - 0.00033 20.1 0.1 0.00059 19.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CRG83182.1 - 0.005 16.2 0.0 0.0081 15.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like WaaY PF06176.11 CRG83182.1 - 0.0072 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) RIO1 PF01163.22 CRG83182.1 - 0.011 15.4 0.1 0.019 14.6 0.1 1.3 1 0 0 1 1 1 0 RIO1 family BAAT_C PF08840.11 CRG83182.1 - 0.03 14.2 0.0 0.65 9.9 0.0 2.1 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 CRG83182.1 - 0.033 13.8 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) LIDHydrolase PF10230.9 CRG83182.1 - 0.052 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Kelch_5 PF13854.6 CRG83183.1 - 1.4e-12 47.3 2.1 6.5e-12 45.2 0.4 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 CRG83183.1 - 2.7e-06 26.9 0.3 0.045 13.4 0.1 4.6 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 CRG83183.1 - 0.00054 20.1 1.2 0.011 16.0 0.1 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 CRG83183.1 - 0.0023 18.2 12.0 0.39 11.1 0.1 6.1 6 1 0 6 6 6 1 Galactose oxidase, central domain Miga PF10265.9 CRG83183.1 - 0.0024 17.0 0.2 0.0037 16.3 0.2 1.2 1 0 0 1 1 1 1 Mitoguardin TNFR_16_TM PF18422.1 CRG83183.1 - 0.045 13.7 0.1 0.1 12.5 0.1 1.5 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TMEMspv1-c74-12 PF11044.8 CRG83183.1 - 1.3 9.1 2.6 1.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Response_reg PF00072.24 CRG83184.1 - 1.1 9.5 4.4 0.77 9.9 0.2 3.0 4 0 0 4 4 4 0 Response regulator receiver domain ERG4_ERG24 PF01222.17 CRG83185.1 - 6.4e-143 476.6 18.2 7.5e-143 476.4 18.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family PalH PF08733.10 CRG83185.1 - 0.041 12.9 6.2 0.1 11.6 6.2 1.6 1 1 0 1 1 1 0 PalH/RIM21 DUF3390 PF11870.8 CRG83185.1 - 0.13 12.6 2.3 2.7 8.4 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) P_C PF06640.11 CRG83185.1 - 1.7 8.7 4.6 2.5 8.2 4.6 1.2 1 0 0 1 1 1 0 P protein C-terminus zf-C3HC4_2 PF13923.6 CRG83187.1 - 1.3e-07 31.4 6.7 2.6e-06 27.2 3.5 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG83187.1 - 3.2e-07 30.1 6.5 6.7e-07 29.1 6.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG83187.1 - 7.3e-06 26.2 8.3 0.00014 22.1 8.9 2.2 1 1 1 2 2 2 2 Ring finger domain zf-C3HC4_3 PF13920.6 CRG83187.1 - 9.3e-06 25.4 5.7 2e-05 24.3 5.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG83187.1 - 1.8e-05 24.7 3.5 1.8e-05 24.7 3.5 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 CRG83187.1 - 3.5e-05 23.9 5.7 0.0002 21.5 6.2 2.0 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CRG83187.1 - 7.4e-05 22.6 5.0 0.0002 21.2 5.0 1.8 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG83187.1 - 0.063 13.1 8.2 0.72 9.8 8.3 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 TerY_C PF15616.6 CRG83187.1 - 0.17 12.0 0.6 0.37 10.9 0.6 1.5 1 0 0 1 1 1 0 TerY-C metal binding domain zf-MIZ PF02891.20 CRG83187.1 - 0.38 10.5 9.3 1.3 8.9 8.3 2.1 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_11 PF17123.5 CRG83187.1 - 1.4 8.7 6.9 10 5.9 4.7 2.6 2 1 0 2 2 2 0 RING-like zinc finger UCH PF00443.29 CRG83188.1 - 1.4e-45 155.8 0.0 2.1e-45 155.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG83188.1 - 2.5e-11 43.8 0.0 9.2e-05 22.2 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RNase_H PF00075.24 CRG83189.1 - 1.7e-36 125.6 0.0 2.9e-36 124.8 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 CRG83189.1 - 7.7e-34 115.7 4.4 4.3e-16 58.9 0.5 2.6 2 0 0 2 2 2 2 Caulimovirus viroplasmin RVT_3 PF13456.6 CRG83189.1 - 0.0097 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase-like Na_H_Exchanger PF00999.21 CRG83190.1 - 3.6e-49 167.6 20.7 4.6e-49 167.2 20.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family 7TM_GPCR_Srv PF10323.9 CRG83190.1 - 0.036 13.4 0.1 0.084 12.2 0.1 1.5 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv Vma12 PF11712.8 CRG83190.1 - 0.52 10.4 2.7 16 5.5 0.1 2.4 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase MFS_1 PF07690.16 CRG83191.1 - 2.7e-26 92.3 13.1 5.2e-22 78.3 0.5 2.9 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_4 PF06779.14 CRG83191.1 - 7.8e-06 25.4 1.6 1.1e-05 24.9 0.3 1.9 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB FMN_dh PF01070.18 CRG83192.1 - 1.3e-107 359.8 0.0 1.6e-107 359.6 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG83192.1 - 8.5e-19 67.5 0.0 1.8e-18 66.4 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CRG83192.1 - 1.4e-05 24.4 0.0 2.1e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG83192.1 - 1.7e-05 24.0 0.1 0.00081 18.5 0.0 2.7 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CRG83192.1 - 0.027 14.0 0.1 0.19 11.2 0.0 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein DUF202 PF02656.15 CRG83193.1 - 0.056 13.9 8.7 0.34 11.4 8.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF202) 6PF2K PF01591.18 CRG83194.1 - 1.2e-69 234.0 0.0 2.5e-48 164.3 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CRG83194.1 - 1.2e-31 110.0 0.1 1.1e-24 87.2 0.0 2.9 3 0 0 3 3 3 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 CRG83194.1 - 0.00015 22.0 0.0 0.19 11.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain KTI12 PF08433.10 CRG83194.1 - 0.13 11.7 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Pkinase PF00069.25 CRG83195.1 - 2.2e-20 73.1 0.0 2.5e-20 72.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83195.1 - 6.8e-13 48.5 0.0 1.6e-12 47.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CRG83195.1 - 0.00038 19.9 0.0 0.00049 19.5 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family WaaY PF06176.11 CRG83195.1 - 0.0057 16.3 0.0 0.0073 16.0 0.0 1.1 1 0 0 1 1 1 1 Lipopolysaccharide core biosynthesis protein (WaaY) Kinase-like PF14531.6 CRG83195.1 - 0.025 13.9 0.0 0.06 12.7 0.0 1.6 1 1 0 1 1 1 0 Kinase-like FTA2 PF13095.6 CRG83195.1 - 0.037 13.7 0.0 0.044 13.4 0.0 1.1 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 CRG83195.1 - 0.037 13.6 0.0 0.047 13.3 0.0 1.2 1 0 0 1 1 1 0 RIO1 family PIP49_C PF12260.8 CRG83195.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 APH PF01636.23 CRG83195.1 - 0.17 11.7 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DSBA PF01323.20 CRG83196.1 - 6.3e-37 127.2 0.0 7.1e-37 127.1 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 CRG83196.1 - 0.0011 19.1 0.2 0.016 15.4 0.2 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_3 PF13192.6 CRG83196.1 - 0.022 14.8 0.0 0.58 10.2 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin domain DIM PF08194.12 CRG83198.1 - 0.21 11.8 0.2 0.21 11.8 0.2 2.7 2 0 0 2 2 2 0 DIM protein HSP70 PF00012.20 CRG83199.1 - 2.9e-258 858.0 9.0 3.3e-258 857.8 9.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CRG83199.1 - 9.9e-18 64.0 0.2 1e-16 60.7 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CRG83199.1 - 0.0011 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 CRG83199.1 - 0.026 13.8 0.1 0.072 12.3 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase StbA PF06406.11 CRG83199.1 - 0.035 13.3 0.0 0.067 12.4 0.0 1.4 1 0 0 1 1 1 0 StbA protein FtsA PF14450.6 CRG83199.1 - 0.059 13.8 7.2 10 6.6 0.3 3.7 3 2 0 3 3 3 0 Cell division protein FtsA CHZ PF09649.10 CRG83200.1 - 3.7e-15 55.1 1.7 3.7e-15 55.1 1.7 2.2 2 0 0 2 2 2 1 Histone chaperone domain CHZ CDC27 PF09507.10 CRG83200.1 - 0.37 10.1 15.5 0.42 10.0 15.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CobT PF06213.12 CRG83200.1 - 1.6 8.1 20.4 1.9 7.8 20.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT WRNPLPNID PF15017.6 CRG83200.1 - 7.9 7.4 17.9 4.9 8.1 6.3 2.3 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Use1 PF09753.9 CRG83201.1 - 0.0011 18.7 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 Apc15p PF05841.11 CRG83202.1 - 1.6e-15 58.0 0.3 6.9e-15 56.0 0.0 2.1 2 0 0 2 2 2 1 Apc15p protein GATase_2 PF00310.21 CRG83203.1 - 8.1e-181 601.3 0.0 1.1e-180 600.9 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 CRG83203.1 - 5.1e-157 522.7 0.0 7.3e-157 522.2 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 CRG83203.1 - 6.3e-115 383.5 0.0 1.8e-111 372.1 0.0 2.2 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 CRG83203.1 - 1.8e-84 282.1 4.7 2.9e-84 281.4 4.7 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 CRG83203.1 - 8.4e-27 94.1 0.1 3e-26 92.3 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 CRG83203.1 - 2.7e-21 75.4 0.1 5.4e-21 74.5 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 CRG83203.1 - 5.3e-09 36.2 0.0 1.8e-08 34.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG83203.1 - 7.5e-09 36.0 0.1 1.2e-05 25.7 0.2 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG83203.1 - 1.1e-07 31.8 1.7 0.0019 17.9 0.7 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG83203.1 - 1.9e-07 30.6 2.5 0.032 13.5 0.1 3.7 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG83203.1 - 5.1e-07 29.3 0.1 1e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CRG83203.1 - 8.2e-06 25.4 0.2 1.8e-05 24.3 0.2 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG83203.1 - 3.2e-05 23.2 0.3 0.00027 20.1 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CRG83203.1 - 5.7e-05 22.0 0.2 5.7e-05 22.0 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_7 PF13241.6 CRG83203.1 - 0.00016 22.1 0.1 1.2 9.6 0.1 3.2 3 0 0 3 3 3 2 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CRG83203.1 - 0.00025 20.4 0.0 0.00066 19.0 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CRG83203.1 - 0.00035 19.9 0.2 0.019 14.2 0.1 3.0 3 0 0 3 3 3 1 Thi4 family Lycopene_cycl PF05834.12 CRG83203.1 - 0.0017 17.5 0.4 0.35 9.9 0.2 2.4 2 0 0 2 2 2 1 Lycopene cyclase protein FMO-like PF00743.19 CRG83203.1 - 0.0026 16.3 0.1 0.73 8.2 0.0 2.9 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like AlaDh_PNT_C PF01262.21 CRG83203.1 - 0.0031 16.8 0.4 0.47 9.7 0.1 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CRG83203.1 - 0.03 13.4 0.2 0.03 13.4 0.2 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CRG83203.1 - 0.04 13.3 0.4 0.18 11.1 0.0 2.2 3 0 0 3 3 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FMN_dh PF01070.18 CRG83203.1 - 0.08 12.0 2.3 0.25 10.3 1.9 2.0 2 0 0 2 2 2 0 FMN-dependent dehydrogenase AdoHcyase_NAD PF00670.21 CRG83203.1 - 0.2 11.7 1.7 23 5.0 0.2 2.9 3 0 0 3 3 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain MADF_DNA_bdg PF10545.9 CRG83203.1 - 0.24 11.7 0.4 0.56 10.6 0.4 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Rossmann-like PF10727.9 CRG83203.1 - 0.34 10.8 1.7 3.1 7.7 0.1 2.5 2 0 0 2 2 2 0 Rossmann-like domain DUF3128 PF11326.8 CRG83204.1 - 5.9e-26 90.6 4.4 9.5e-26 90.0 4.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) RNA12 PF10443.9 CRG83205.1 - 1.7e-164 547.8 0.2 3.1e-164 546.9 0.2 1.4 1 0 0 1 1 1 1 RNA12 protein ATPase_2 PF01637.18 CRG83205.1 - 1.2e-05 25.3 0.1 7.7e-05 22.7 0.1 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea RRM_1 PF00076.22 CRG83205.1 - 4.1e-05 23.3 0.0 9.3e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_16 PF13191.6 CRG83205.1 - 0.0074 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain HTH_20 PF12840.7 CRG83205.1 - 0.14 12.2 0.0 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain ScsC_N PF18312.1 CRG83205.1 - 0.3 10.9 2.3 2.4 8.0 0.0 2.7 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain p450 PF00067.22 CRG83206.1 - 4.3e-09 35.6 0.0 1.9e-07 30.2 0.0 2.4 2 1 0 2 2 2 2 Cytochrome P450 MFS_1 PF07690.16 CRG83207.1 - 9.6e-38 130.0 19.8 9.6e-38 130.0 19.8 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG83207.1 - 0.0016 17.8 10.6 0.012 14.9 3.7 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF2721 PF11026.8 CRG83207.1 - 7 6.6 11.7 0.22 11.4 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) FliD_C PF07195.12 CRG83208.1 - 0.041 13.3 1.8 0.086 12.3 1.8 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Mltc_N PF11873.8 CRG83208.1 - 0.099 12.4 3.5 0.16 11.7 3.5 1.3 1 0 0 1 1 1 0 Membrane-bound lytic murein transglycosylase C, N-terminal domain Ax_dynein_light PF10211.9 CRG83208.1 - 1.8 8.5 10.7 3.5 7.6 10.7 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain MFS_1 PF07690.16 CRG83209.1 - 5.3e-37 127.5 24.2 5.3e-37 127.5 24.2 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily LacY_symp PF01306.19 CRG83209.1 - 0.00015 20.6 0.5 0.00015 20.6 0.5 2.0 2 0 0 2 2 2 1 LacY proton/sugar symporter MMU163 PF17119.5 CRG83210.1 - 1.8e-108 361.4 0.0 3.1e-108 360.6 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis NUDIX PF00293.28 CRG83210.1 - 6.8e-11 42.3 0.0 1.4e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain Herpes_pp85 PF04637.12 CRG83210.1 - 6.5 5.1 5.0 9.5 4.5 5.0 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) VTC PF09359.10 CRG83211.1 - 1.3e-89 300.2 1.0 1.7e-89 299.9 0.0 1.6 2 0 0 2 2 2 1 VTC domain DUF202 PF02656.15 CRG83211.1 - 8.8e-11 42.1 3.7 8.8e-11 42.1 3.7 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 CRG83211.1 - 3.8e-08 33.6 15.2 0.00019 21.5 0.2 3.7 2 1 2 4 4 4 3 SPX domain CYTH PF01928.21 CRG83211.1 - 0.0093 15.9 0.1 0.022 14.7 0.1 1.6 1 0 0 1 1 1 1 CYTH domain KxDL PF10241.9 CRG83211.1 - 0.087 13.1 2.6 0.25 11.6 2.6 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein IL15 PF02372.15 CRG83211.1 - 0.37 10.8 1.5 0.98 9.4 1.5 1.7 1 0 0 1 1 1 0 Interleukin 15 Mito_carr PF00153.27 CRG83212.1 - 3.9e-29 100.4 2.0 2.8e-14 52.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Atg8 PF02991.16 CRG83213.1 - 3.4e-51 171.8 0.2 4e-51 171.5 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 CRG83213.1 - 4.1e-06 27.1 0.0 4.9e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 RNA_pol_Rpb1_1 PF04997.12 CRG83214.1 - 2.8e-81 273.3 1.1 3.3e-81 273.0 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CRG83214.1 - 1.2e-77 261.0 1.6 1.8e-77 260.4 1.6 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CRG83214.1 - 6.8e-69 231.3 0.0 1.9e-68 229.9 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CRG83214.1 - 5.2e-35 120.7 0.0 2e-34 118.8 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 CRG83214.1 - 1.6e-27 95.6 0.1 4.7e-27 94.1 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Filament PF00038.21 CRG83214.1 - 0.0056 16.3 0.2 0.012 15.3 0.2 1.4 1 0 0 1 1 1 1 Intermediate filament protein Coprogen_oxidas PF01218.18 CRG83215.1 - 6.7e-135 448.5 0.0 1.8e-134 447.1 0.0 1.7 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase DUF1651 PF07864.11 CRG83215.1 - 0.046 14.1 0.1 0.14 12.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1651) HOOK PF05622.12 CRG83216.1 - 6.2e-31 107.3 63.4 8.6e-29 100.2 30.0 3.1 2 1 1 3 3 3 3 HOOK protein DASH_Hsk3 PF08227.11 CRG83216.1 - 0.02 15.2 6.2 19 5.7 1.4 5.1 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like DUF1411 PF07199.11 CRG83216.1 - 0.11 12.2 4.4 0.16 11.6 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) DUF4241 PF14025.6 CRG83216.1 - 0.25 11.6 1.2 0.96 9.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) FlaC_arch PF05377.11 CRG83216.1 - 0.31 11.5 41.2 0.044 14.2 1.9 8.0 8 1 0 8 8 8 0 Flagella accessory protein C (FlaC) KASH_CCD PF14662.6 CRG83216.1 - 0.34 10.7 84.2 2.9 7.7 14.7 6.1 2 2 2 5 5 5 0 Coiled-coil region of CCDC155 or KASH TPR_MLP1_2 PF07926.12 CRG83216.1 - 0.36 10.9 90.0 0.11 12.6 3.7 7.7 3 2 3 7 7 7 0 TPR/MLP1/MLP2-like protein T7SS_ESX_EspC PF10824.8 CRG83216.1 - 0.47 11.0 0.0 0.47 11.0 0.0 4.2 3 1 0 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm HALZ PF02183.18 CRG83216.1 - 2.6 8.3 36.8 0.081 13.2 1.0 7.8 6 2 2 8 8 8 0 Homeobox associated leucine zipper Atg14 PF10186.9 CRG83216.1 - 3.2 6.8 71.5 0.15 11.1 9.3 5.1 2 2 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Scaffolding_pro PF11418.8 CRG83216.1 - 8.8 7.0 23.3 0.51 10.9 2.8 5.3 4 1 1 6 6 6 0 Phi29 scaffolding protein Inhibitor_I9 PF05922.16 CRG83217.1 - 0.0036 17.9 0.0 0.0052 17.4 0.0 1.4 1 1 0 1 1 1 1 Peptidase inhibitor I9 MctB PF11382.8 CRG83217.1 - 0.046 13.4 0.0 0.051 13.3 0.0 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB CFIA_Pcf11 PF11526.8 CRG83218.1 - 3e-08 34.0 1.8 1.3e-07 32.0 1.8 2.1 1 1 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 CTD_bind PF04818.13 CRG83218.1 - 5e-06 27.2 0.0 1.8e-05 25.4 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. VHS PF00790.19 CRG83218.1 - 0.014 15.2 0.0 0.044 13.6 0.0 1.8 1 0 0 1 1 1 0 VHS domain Spem1 PF15670.5 CRG83218.1 - 0.042 13.4 0.1 0.072 12.7 0.1 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 zf_UBZ PF18439.1 CRG83218.1 - 0.51 10.0 6.5 0.79 9.4 1.7 2.8 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 CRG83218.1 - 0.59 11.1 4.1 15 6.8 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CRG83218.1 - 1.3 9.1 4.6 21 5.2 0.1 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 CRG83218.1 - 2.9 8.5 5.9 3 8.5 0.4 2.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type GFO_IDH_MocA PF01408.22 CRG83219.1 - 1e-16 61.8 0.0 1.7e-16 61.1 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG83219.1 - 0.026 15.2 0.0 0.045 14.4 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Ntox27 PF15531.6 CRG83219.1 - 0.12 12.3 0.0 0.3 11.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial toxin 27 ADK PF00406.22 CRG83220.1 - 8.4e-61 204.5 0.1 1e-60 204.2 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CRG83220.1 - 5.7e-23 81.8 0.1 1e-22 81.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 CRG83220.1 - 1.6e-17 63.2 0.0 3.6e-17 62.0 0.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 CRG83220.1 - 4.3e-06 27.3 0.0 7.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CRG83220.1 - 1.4e-05 25.3 0.0 2.4e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain MitMem_reg PF13012.6 CRG83221.1 - 3.5e-37 127.3 0.1 6.4e-37 126.4 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 CRG83221.1 - 4.3e-30 104.1 0.0 1e-29 102.9 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF2999 PF11212.8 CRG83221.1 - 0.071 13.4 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) UCH PF00443.29 CRG83222.1 - 2e-11 43.9 0.0 4.8e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG83222.1 - 6.8e-11 42.3 0.0 1.6e-10 41.1 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SWIM PF04434.17 CRG83222.1 - 0.1 12.3 2.8 0.54 10.0 0.0 2.6 2 0 0 2 2 2 0 SWIM zinc finger Myb_DNA-binding PF00249.31 CRG83223.1 - 5.8e-14 52.0 2.1 5.4e-11 42.5 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG83223.1 - 6.3e-05 23.1 3.1 0.011 16.0 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Methyltransf_11 PF08241.12 CRG83224.1 - 1.5e-10 41.6 0.0 2.8e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83224.1 - 4.8e-09 36.8 0.0 1e-08 35.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG83224.1 - 7.1e-05 22.7 0.0 0.00025 20.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG83224.1 - 0.00022 21.9 0.0 0.00048 20.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG83224.1 - 0.0027 17.5 0.0 0.005 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CAP_GLY PF01302.25 CRG83225.1 - 1.8e-24 85.5 0.0 2.7e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 CRG83225.1 - 4e-13 49.6 0.0 7.6e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 CRG83225.1 - 0.00047 19.9 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Mif2_N PF15624.6 CRG83227.1 - 1.4e-33 116.5 7.1 1.4e-33 116.5 7.1 3.2 2 1 1 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal CENP-C_C PF11699.8 CRG83227.1 - 2.7e-33 114.0 0.5 5.3e-33 113.1 0.5 1.5 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 CRG83227.1 - 1.8e-07 30.7 0.0 4.4e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Cupin domain RNase_HII PF01351.18 CRG83228.1 - 1.5e-47 162.0 0.0 1.1e-46 159.1 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease HII Pex16 PF08610.10 CRG83229.1 - 1.1e-135 452.0 0.1 1.3e-135 451.8 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) SAE2 PF08573.10 CRG83230.1 - 1.7e-32 112.8 0.3 1.7e-32 112.8 0.3 4.4 3 2 1 4 4 4 1 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF1140 PF06600.11 CRG83230.1 - 0.1 13.1 1.4 0.25 11.8 1.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1140) TRAF_BIRC3_bd PF16673.5 CRG83230.1 - 5.6 6.8 11.5 13 5.6 5.6 3.0 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain CRT10 PF08728.10 CRG83230.1 - 9.4 4.3 7.3 13 3.7 7.3 1.2 1 0 0 1 1 1 0 CRT10 F-box PF00646.33 CRG83231.1 - 1.9e-10 40.3 0.4 3.6e-10 39.5 0.4 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG83231.1 - 4.9e-09 35.9 0.3 9.3e-09 35.1 0.3 1.5 1 0 0 1 1 1 1 F-box-like zf-CCHC PF00098.23 CRG83232.1 - 1.9e-49 163.6 63.7 7.4e-09 35.3 1.8 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 CRG83232.1 - 2.8e-10 39.8 44.1 0.027 14.2 1.3 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_3 PF13917.6 CRG83232.1 - 0.0002 21.3 50.4 0.027 14.4 1.1 7.0 3 2 4 7 7 7 6 Zinc knuckle zf-CCHC_5 PF14787.6 CRG83232.1 - 0.00031 20.4 44.6 0.76 9.5 1.2 7.5 5 1 2 7 7 7 7 GAG-polyprotein viral zinc-finger UPF0061 PF02696.14 CRG83233.1 - 1.3e-122 410.0 0.0 1.7e-122 409.5 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Molybdopterin PF00384.22 CRG83234.1 - 6.4e-74 249.4 0.0 6.1e-38 130.9 0.0 2.2 1 1 1 2 2 2 2 Molybdopterin oxidoreductase Fer2_4 PF13510.6 CRG83234.1 - 9.1e-21 73.7 0.1 2.5e-20 72.3 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 CRG83234.1 - 7.8e-18 64.9 0.1 2.4e-17 63.3 0.1 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 CRG83234.1 - 2.8e-17 62.0 0.2 2.8e-17 62.0 0.2 2.2 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 CRG83234.1 - 1.2e-08 34.7 0.5 1.2e-08 34.7 0.5 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 CRG83234.1 - 0.004 16.9 0.0 0.11 12.2 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 CRG83234.1 - 0.12 12.2 1.1 3.4 7.6 0.3 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_19 PF06902.11 CRG83234.1 - 0.22 11.6 2.0 3.9 7.6 2.0 2.5 1 1 0 1 1 1 0 Divergent 4Fe-4S mono-cluster XRCC4 PF06632.12 CRG83235.1 - 0.00065 18.7 19.7 0.0031 16.4 19.7 2.1 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF3585 PF12130.8 CRG83235.1 - 0.0091 16.1 7.2 0.025 14.7 7.2 1.7 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain XhlA PF10779.9 CRG83235.1 - 0.043 14.0 0.2 0.043 14.0 0.2 2.8 3 0 0 3 3 3 0 Haemolysin XhlA ALMT PF11744.8 CRG83235.1 - 7 5.4 7.3 8.4 5.1 7.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter ER_lumen_recept PF00810.18 CRG83238.1 - 1.4e-55 188.2 7.0 2.4e-55 187.4 7.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 CRG83238.1 - 0.00061 19.5 8.0 1 9.2 0.2 3.9 3 1 0 3 3 3 3 PQ loop repeat DUF382 PF04037.13 CRG83239.1 - 3.2e-58 195.4 0.9 6.5e-58 194.4 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 CRG83239.1 - 4e-20 71.4 4.9 9.6e-20 70.2 4.9 1.7 1 0 0 1 1 1 1 PSP MRP-S33 PF08293.11 CRG83240.1 - 3.1e-30 104.3 0.0 3.7e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ribonuclease_3 PF00636.26 CRG83241.1 - 4.4e-15 56.2 0.0 9.8e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CRG83241.1 - 1.4e-09 38.2 0.0 2.1e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 CRG83241.1 - 0.01 16.5 0.0 0.032 15.0 0.0 1.9 2 0 0 2 2 2 0 Double-stranded RNA binding motif AA_permease_2 PF13520.6 CRG83242.1 - 1.1e-40 139.8 43.6 4.6e-40 137.7 43.6 1.7 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG83242.1 - 1.5e-18 66.7 41.3 9.8e-12 44.2 16.4 2.2 2 1 0 2 2 2 2 Amino acid permease Abhydrolase_1 PF00561.20 CRG83243.1 - 1.3e-13 51.2 0.0 5.7e-12 45.8 0.0 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CRG83243.1 - 5.1e-09 36.2 0.0 2e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 TAP-like protein FMO-like PF00743.19 CRG83244.1 - 2.3e-15 56.0 0.0 1.3e-10 40.4 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG83244.1 - 2.3e-13 50.1 0.0 2e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG83244.1 - 1.9e-12 47.1 0.0 2.2e-10 40.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG83244.1 - 6.9e-07 28.7 0.0 2.1e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CRG83244.1 - 2.3e-05 24.5 0.4 7.2e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG83244.1 - 0.00032 20.4 0.0 0.0095 15.6 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG83244.1 - 0.00045 19.5 0.0 0.00085 18.6 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CRG83244.1 - 0.0017 17.1 0.1 1.2 7.7 0.0 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 CRG83244.1 - 0.012 15.0 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CRG83244.1 - 0.17 11.1 0.2 1.5 8.0 0.1 2.0 1 1 0 2 2 2 0 FAD binding domain MFS_1 PF07690.16 CRG83245.1 - 0.013 14.4 4.7 0.021 13.8 4.7 1.3 1 0 0 1 1 1 0 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83246.1 - 6.4e-125 417.5 22.5 7.4e-125 417.3 22.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83246.1 - 2.5e-22 79.3 27.4 2.5e-22 79.3 27.4 1.9 1 1 2 3 3 3 1 Major Facilitator Superfamily SMP_2 PF10144.9 CRG83247.1 - 0.19 11.3 0.0 0.38 10.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial virulence factor haemolysin Gly-zipper_YMGG PF13441.6 CRG83247.1 - 0.6 9.9 6.2 1.6 8.5 6.2 1.6 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 CRG83247.1 - 0.94 9.3 6.6 2.8 7.8 6.6 1.8 1 0 0 1 1 1 0 Glycine-zipper domain ApbA PF02558.16 CRG83248.1 - 8.2e-18 64.5 0.0 2.3e-17 63.0 0.0 1.8 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Epimerase PF01370.21 CRG83248.1 - 1.9e-09 37.3 0.2 5.2e-05 22.8 0.1 3.2 3 0 0 3 3 3 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG83248.1 - 2.7e-07 30.7 0.6 3.4e-06 27.1 0.1 2.4 2 0 0 2 2 2 1 NAD(P)H-binding MFS_1 PF07690.16 CRG83248.1 - 4.4e-06 25.9 20.7 4.4e-06 25.9 20.7 2.5 1 1 1 2 2 2 1 Major Facilitator Superfamily F420_oxidored PF03807.17 CRG83248.1 - 5e-06 27.0 0.2 0.0041 17.7 0.0 2.6 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Pyr_redox_2 PF07992.14 CRG83248.1 - 2.1e-05 23.9 0.0 5.9e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CRG83248.1 - 3e-05 24.1 0.1 0.092 12.8 0.0 2.4 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 CRG83248.1 - 9.6e-05 21.5 0.0 0.028 13.4 0.0 2.3 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CRG83248.1 - 0.00012 22.5 0.0 0.00037 20.9 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Pyr_redox PF00070.27 CRG83248.1 - 0.00025 21.5 0.1 0.00097 19.6 0.1 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase NmrA PF05368.13 CRG83248.1 - 0.00033 20.3 0.3 0.038 13.5 0.0 2.3 2 0 0 2 2 2 1 NmrA-like family NAD_binding_7 PF13241.6 CRG83248.1 - 0.00081 19.8 0.1 0.0036 17.7 0.0 2.1 2 0 0 2 2 1 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 CRG83248.1 - 0.0018 18.5 0.2 0.0051 17.0 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_Gly3P_dh_N PF01210.23 CRG83248.1 - 0.0029 17.6 0.0 0.027 14.5 0.0 2.4 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DAO PF01266.24 CRG83248.1 - 0.0045 16.6 0.3 0.015 14.9 0.2 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase GDP_Man_Dehyd PF16363.5 CRG83248.1 - 0.0053 16.2 0.3 5.2 6.4 0.0 3.1 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG83248.1 - 0.013 14.6 0.3 0.072 12.2 0.3 2.0 1 1 0 1 1 1 0 Male sterility protein Pyr_redox_3 PF13738.6 CRG83248.1 - 0.014 14.7 0.1 0.036 13.3 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CRG83248.1 - 0.014 15.3 0.0 0.041 13.8 0.0 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG83248.1 - 0.02 14.0 0.0 0.035 13.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TrkA_N PF02254.18 CRG83248.1 - 0.027 14.7 0.1 6.9 7.0 0.1 2.5 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_2 PF03446.15 CRG83248.1 - 0.048 13.8 0.0 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 CRG83248.1 - 0.051 13.1 0.3 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 CRG83248.1 - 0.062 12.5 0.1 0.1 11.8 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain ThiF PF00899.21 CRG83248.1 - 0.099 12.0 0.0 0.31 10.4 0.0 1.8 2 0 0 2 2 2 0 ThiF family XdhC_C PF13478.6 CRG83248.1 - 0.13 12.8 0.0 0.33 11.5 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain Sacchrp_dh_NADP PF03435.18 CRG83248.1 - 0.14 12.4 0.5 21 5.4 0.1 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Zincin_2 PF10103.9 CRG83248.1 - 0.15 11.3 0.0 0.15 11.3 0.0 1.7 2 0 0 2 2 1 0 Zincin-like metallopeptidase AvrL567-A PF11529.8 CRG83248.1 - 0.19 12.0 0.0 0.51 10.5 0.0 1.7 2 0 0 2 2 1 0 Melampsora lini avirulence protein AvrL567-A Aldedh PF00171.22 CRG83249.1 - 1.7e-176 587.3 0.0 2.2e-176 586.9 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FMN_dh PF01070.18 CRG83249.1 - 4.5e-109 364.7 0.0 3.7e-108 361.7 0.0 2.3 2 1 0 2 2 2 1 FMN-dependent dehydrogenase IMPDH PF00478.25 CRG83249.1 - 7.4e-05 21.9 0.0 0.00014 20.9 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 CRG83249.1 - 0.00088 18.5 0.0 0.0015 17.8 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase His_biosynth PF00977.21 CRG83249.1 - 0.038 13.5 0.0 0.087 12.3 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Aldedh PF00171.22 CRG83250.1 - 2e-132 442.0 0.1 2.3e-132 441.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CRG83250.1 - 0.15 11.0 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Fungal_trans_2 PF11951.8 CRG83251.1 - 2.1e-48 165.1 4.2 2.6e-48 164.7 4.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83251.1 - 1.4e-09 37.9 7.6 2.3e-09 37.2 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHDPS PF00701.22 CRG83252.1 - 1.8e-61 207.4 0.0 2e-61 207.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Aa_trans PF01490.18 CRG83253.1 - 2e-40 138.8 40.0 2.6e-40 138.4 40.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_1 PF00561.20 CRG83254.1 - 2.2e-16 60.3 0.0 4.8e-14 52.6 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CRG83254.1 - 4.8e-15 55.5 0.0 4.6e-14 52.4 0.0 2.2 2 0 0 2 2 2 1 TAP-like protein YccV-like PF08755.11 CRG83256.1 - 2.4e-28 98.5 0.2 5.2e-28 97.4 0.2 1.6 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Glyco_hydro_79C PF16862.5 CRG83256.1 - 2.2e-20 73.4 2.9 6.1e-20 72.0 1.4 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Transglut_core2 PF13369.6 CRG83256.1 - 1e-15 57.6 0.0 1.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Transglutaminase-like superfamily F-box-like PF12937.7 CRG83256.1 - 2.6e-07 30.4 0.3 5.4e-07 29.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG83256.1 - 0.0083 16.0 0.1 0.023 14.6 0.0 1.8 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 CRG83256.1 - 0.015 15.2 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 F-box Cadherin_5 PF17892.1 CRG83256.1 - 0.037 14.0 0.2 0.087 12.8 0.2 1.7 1 0 0 1 1 1 0 Cadherin-like domain DnaJ PF00226.31 CRG83257.1 - 4.9e-23 81.0 2.7 1.5e-22 79.5 2.7 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 CRG83257.1 - 4e-10 39.7 5.9 4e-10 39.7 5.9 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG83257.1 - 3e-09 37.0 9.5 7.4e-09 35.7 1.4 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CRG83257.1 - 3e-07 30.7 8.2 0.00026 21.3 1.0 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CRG83257.1 - 3.7e-05 24.2 7.5 0.027 15.3 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG83257.1 - 0.00015 22.1 9.7 0.085 13.3 2.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CRG83257.1 - 0.0031 17.5 11.3 0.18 11.9 3.0 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG83257.1 - 0.4 11.2 6.1 0.33 11.5 0.2 2.9 3 0 0 3 3 3 0 Zinc-finger double domain PSCyt3 PF07627.11 CRG83257.1 - 7.7 6.9 8.8 0.21 11.9 0.3 2.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1588) R3H PF01424.22 CRG83258.1 - 1.1e-12 47.7 0.0 2.5e-12 46.6 0.0 1.7 1 0 0 1 1 1 1 R3H domain G-patch PF01585.23 CRG83258.1 - 5.9e-10 38.9 1.5 1.6e-09 37.5 1.5 1.8 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CRG83258.1 - 0.0011 19.0 1.0 0.0011 19.0 1.0 2.8 2 0 0 2 2 2 1 G-patch domain Peptidase_C54 PF03416.19 CRG83259.1 - 4.9e-98 327.9 0.0 6.3e-98 327.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Ndc1_Nup PF09531.10 CRG83259.1 - 0.14 10.8 0.4 0.17 10.5 0.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Histone PF00125.24 CRG83260.1 - 1.4e-21 77.2 0.6 1.8e-21 76.9 0.6 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CRG83260.1 - 0.00021 21.5 0.0 0.00021 21.5 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 CRG83260.1 - 0.00042 20.8 0.0 0.0007 20.0 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 CRG83260.1 - 0.036 14.1 0.2 0.043 13.9 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein RP-C PF03428.13 CRG83260.1 - 0.054 13.1 0.1 0.14 11.8 0.1 1.6 1 1 0 1 1 1 0 Replication protein C N-terminal domain DUF1018 PF06252.12 CRG83260.1 - 0.072 14.1 0.3 0.1 13.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Histone_H2A_C PF16211.5 CRG83261.1 - 4.3e-21 74.4 2.8 7.6e-21 73.6 2.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 CRG83261.1 - 2.8e-17 63.3 0.0 3.8e-17 62.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CRG83261.1 - 1e-05 25.7 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Complex1_LYR PF05347.15 CRG83262.1 - 1.5e-10 41.0 0.4 2e-10 40.6 0.4 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) 2-oxoacid_dh PF00198.23 CRG83263.1 - 1.3e-79 267.0 0.1 1.7e-79 266.6 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CRG83263.1 - 3.6e-18 65.2 2.0 6.7e-18 64.3 2.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CRG83263.1 - 0.00019 21.2 0.2 0.0031 17.3 0.1 2.3 1 1 1 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 CRG83263.1 - 0.00027 21.6 0.2 0.046 14.4 0.0 2.4 1 1 1 2 2 2 1 HlyD family secretion protein RnfC_N PF13375.6 CRG83263.1 - 0.034 14.1 0.2 0.38 10.7 0.0 2.3 1 1 1 2 2 2 0 RnfC Barrel sandwich hybrid domain GCV_H PF01597.19 CRG83263.1 - 0.041 13.8 0.3 0.082 12.8 0.3 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein GAGA_bind PF06217.12 CRG83263.1 - 0.29 11.4 3.5 0.41 10.9 3.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CENP-R PF06729.12 CRG83264.1 - 0.0019 18.1 0.1 0.0036 17.2 0.1 1.4 1 0 0 1 1 1 1 Kinetochore component, CENP-R CytoC_RC PF02276.18 CRG83264.1 - 0.067 12.6 0.0 0.095 12.1 0.0 1.2 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit Peptidase_C12 PF01088.21 CRG83265.1 - 1.1e-45 156.0 0.0 1.8e-45 155.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Nrap_D4 PF17405.2 CRG83267.1 - 2.2e-52 177.5 0.3 5e-52 176.3 0.2 1.6 2 0 0 2 2 2 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D5 PF17406.2 CRG83267.1 - 8.4e-51 171.9 0.1 1.9e-50 170.8 0.1 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 CRG83267.1 - 2.3e-43 147.8 0.1 4.8e-43 146.8 0.1 1.6 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D2 PF17403.2 CRG83267.1 - 1.7e-42 144.8 0.0 3.7e-41 140.4 0.0 2.4 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D3 PF17404.2 CRG83267.1 - 5.4e-41 140.3 0.0 1.3e-40 139.0 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 CRG83267.1 - 2.3e-27 95.9 0.0 6.9e-27 94.3 0.0 1.9 1 0 0 1 1 1 1 Nrap protein domain 6 Cys_Met_Meta_PP PF01053.20 CRG83268.1 - 3.8e-31 108.0 0.0 5.1e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CRG83268.1 - 0.062 12.5 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class I and II MRP-L20 PF12824.7 CRG83269.1 - 3e-55 186.8 4.3 3.4e-55 186.7 4.3 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 CRG83269.1 - 0.026 14.5 0.2 0.051 13.6 0.1 1.6 1 1 0 1 1 1 0 Neugrin Peptidase_M20 PF01546.28 CRG83270.1 - 1.9e-32 112.6 0.0 2.4e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG83270.1 - 5e-13 48.9 0.0 8.7e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain SMC_N PF02463.19 CRG83271.1 - 2.5e-17 63.1 19.4 2.4e-16 59.9 19.3 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 CRG83271.1 - 1.9e-10 41.0 12.5 1.9e-10 41.0 12.5 4.1 2 2 0 2 2 1 1 AAA ATPase domain AAA_23 PF13476.6 CRG83271.1 - 1e-08 35.9 36.9 1e-08 35.9 36.9 5.4 2 2 0 2 2 1 1 AAA domain AAA_21 PF13304.6 CRG83271.1 - 5.8e-05 23.0 19.5 0.0019 18.0 9.0 4.2 2 2 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG83271.1 - 0.00072 19.2 0.0 0.0017 18.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Cas_DxTHG PF09455.10 CRG83271.1 - 0.0011 18.7 11.2 0.0011 18.7 11.2 3.1 2 1 0 2 2 1 1 CRISPR-associated (Cas) DxTHG family Glyco_hydro_2_N PF02837.18 CRG83271.1 - 0.017 15.0 0.1 1.8 8.5 0.0 2.4 2 0 0 2 2 2 0 Glycosyl hydrolases family 2, sugar binding domain SMC_hinge PF06470.13 CRG83271.1 - 0.037 14.3 0.1 0.24 11.7 0.0 2.5 3 0 0 3 3 3 0 SMC proteins Flexible Hinge Domain ABC_tran PF00005.27 CRG83271.1 - 0.097 13.2 0.2 0.097 13.2 0.2 5.7 3 2 1 4 4 2 0 ABC transporter DUF357 PF04010.13 CRG83271.1 - 0.29 11.2 3.4 2.6 8.2 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF357) FliJ PF02050.16 CRG83271.1 - 5.6 7.2 93.8 0.1 12.9 7.9 7.9 2 2 5 8 8 8 0 Flagellar FliJ protein DEAD PF00270.29 CRG83272.1 - 8.4e-43 146.2 0.0 1.2e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG83272.1 - 1.9e-28 99.0 1.0 3.9e-27 94.8 0.5 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG83272.1 - 0.0027 17.7 0.0 0.0056 16.7 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Mito_carr PF00153.27 CRG83273.1 - 2.7e-52 174.7 4.4 3.3e-21 75.0 0.2 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein PCRF PF03462.18 CRG83274.1 - 2.7e-48 164.4 0.0 1.1e-47 162.5 0.0 1.9 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 CRG83274.1 - 4.8e-34 116.8 1.0 1e-33 115.7 1.0 1.5 1 0 0 1 1 1 1 RF-1 domain DnaJ PF00226.31 CRG83275.1 - 3.3e-20 72.0 5.0 6.4e-20 71.0 2.4 2.8 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 CRG83275.1 - 7.8e-13 47.7 0.1 0.00014 21.5 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG83275.1 - 1e-12 47.1 0.1 0.01 15.9 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG83275.1 - 5.9e-11 42.7 1.9 0.0021 18.5 0.0 4.4 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 CRG83275.1 - 4.4e-09 36.4 0.8 0.0025 17.9 0.1 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG83275.1 - 4.9e-08 32.6 0.0 0.16 12.2 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG83275.1 - 7.9e-08 32.5 3.5 0.25 12.3 0.1 5.8 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 CRG83275.1 - 4.8e-06 26.9 4.6 19 6.1 0.0 7.5 8 0 0 8 8 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG83275.1 - 8.2e-05 22.8 3.6 0.83 9.9 0.2 4.8 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CRG83275.1 - 0.00014 22.0 0.3 0.04 14.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CRG83275.1 - 0.0031 17.1 0.4 0.28 10.9 0.0 4.0 4 1 0 4 4 4 1 TPR repeat PknG_TPR PF16918.5 CRG83275.1 - 0.022 13.5 0.1 0.92 8.2 0.0 2.9 3 0 0 3 3 3 0 Protein kinase G tetratricopeptide repeat HrpB1_HrpK PF09613.10 CRG83275.1 - 0.032 13.9 0.2 0.39 10.4 0.0 2.5 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_16 PF13432.6 CRG83275.1 - 0.55 10.9 10.8 3.9 8.2 0.3 5.5 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 CRG83275.1 - 0.57 10.6 4.2 5.7 7.3 0.1 4.1 3 3 0 3 3 3 0 Tetratricopeptide repeat VAPB_antitox PF02697.14 CRG83275.1 - 0.75 10.6 5.1 29 5.5 1.1 3.5 3 0 0 3 3 3 0 Putative antitoxin PCMT PF01135.19 CRG83276.1 - 7.3e-55 186.0 0.0 4e-53 180.3 0.0 2.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 CRG83276.1 - 1.2e-08 34.9 0.0 1.9e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83276.1 - 7.7e-06 26.5 0.0 2.3e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 CRG83276.1 - 8.9e-06 25.8 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83276.1 - 0.0027 18.3 0.0 0.0061 17.2 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CRG83276.1 - 0.0033 17.0 0.0 0.0073 15.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain MetW PF07021.12 CRG83276.1 - 0.0036 16.9 0.1 0.0082 15.8 0.0 1.7 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_12 PF08242.12 CRG83276.1 - 0.0059 17.3 0.1 0.016 15.9 0.0 1.8 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG83276.1 - 0.0082 16.0 0.0 0.017 14.9 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_24 PF13578.6 CRG83276.1 - 0.011 16.7 0.0 0.34 12.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.19 CRG83276.1 - 0.015 15.4 0.0 0.087 12.9 0.0 2.0 1 1 1 2 2 2 0 FtsJ-like methyltransferase RrnaAD PF00398.20 CRG83276.1 - 0.082 12.0 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.20 CRG83276.1 - 0.21 10.8 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Pkinase PF00069.25 CRG83277.1 - 1.6e-43 149.0 0.0 1.4e-40 139.3 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83277.1 - 1.8e-09 37.3 0.0 5.1e-05 22.7 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 CRG83277.1 - 0.00017 21.6 0.1 0.055 13.4 0.0 2.8 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG83277.1 - 0.014 14.2 0.0 0.024 13.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 CRG83277.1 - 0.097 12.3 0.0 0.65 9.6 0.0 2.2 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Cnd1_N PF12922.7 CRG83278.1 - 3.3e-61 206.0 1.0 6.7e-61 205.0 1.0 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 CRG83278.1 - 5.1e-48 163.2 2.2 6.4e-43 146.6 0.1 3.4 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CRG83278.1 - 2.6e-10 39.6 6.6 0.069 13.4 0.0 6.4 6 1 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 CRG83278.1 - 9.2e-10 38.8 5.4 4.9e-05 23.6 0.1 4.6 3 1 0 3 3 3 2 HEAT repeats Adaptin_N PF01602.20 CRG83278.1 - 4.9e-07 28.7 4.8 0.0019 16.9 0.5 4.1 4 1 0 4 4 4 2 Adaptin N terminal region HEAT_EZ PF13513.6 CRG83278.1 - 4.6e-05 23.8 9.4 0.067 13.7 0.1 6.1 5 0 0 5 5 5 1 HEAT-like repeat RTP1_C1 PF10363.9 CRG83278.1 - 5.5e-05 23.3 0.8 0.41 10.9 0.0 4.6 4 1 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd3 PF12719.7 CRG83278.1 - 0.0034 16.6 1.6 0.0034 16.6 1.6 3.3 2 2 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain SET PF00856.28 CRG83278.1 - 0.032 14.6 0.0 0.12 12.8 0.0 2.0 1 1 0 1 1 1 0 SET domain Oxysterol_BP PF01237.18 CRG83279.1 - 1.8e-52 178.4 0.0 2.3e-50 171.5 0.0 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein OTU PF02338.19 CRG83280.1 - 1.1e-06 29.2 0.0 1.6e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease Bromodomain PF00439.25 CRG83281.1 - 4.6e-38 129.2 4.6 1.5e-19 69.8 0.4 2.6 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 CRG83281.1 - 1.1e-16 60.8 0.9 2.7e-16 59.5 0.8 1.8 2 0 0 2 2 2 1 BAH domain CDC45 PF02724.14 CRG83281.1 - 0.0023 16.3 0.6 0.0023 16.3 0.6 2.3 2 0 0 2 2 2 1 CDC45-like protein Usp PF00582.26 CRG83281.1 - 0.11 13.0 0.4 3 8.3 0.0 3.0 2 0 0 2 2 2 0 Universal stress protein family DUF87 PF01935.17 CRG83281.1 - 0.45 10.6 2.1 1.1 9.3 2.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain VSG_B PF13206.6 CRG83281.1 - 1.5 8.0 8.6 2.6 7.2 8.6 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain HTH_32 PF13565.6 CRG83281.1 - 3.9 8.2 9.9 4 8.1 1.1 3.8 3 0 0 3 3 3 0 Homeodomain-like domain Sel1 PF08238.12 CRG83282.1 - 4.4e-21 74.8 19.4 3.3e-07 30.8 0.0 6.8 5 1 1 6 6 6 5 Sel1 repeat zf-CCCH PF00642.24 CRG83282.1 - 2.6e-10 40.0 9.5 7.9e-06 25.7 1.9 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CRG83282.1 - 6.1e-09 35.5 9.3 1.2e-05 25.0 2.2 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CRG83282.1 - 6.1e-08 32.5 16.4 0.00013 21.9 1.8 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 CRG83282.1 - 7.1e-08 33.1 4.8 0.0014 19.3 0.3 2.8 1 1 1 2 2 2 2 Torus domain TBPIP PF07106.13 CRG83282.1 - 4.7e-06 26.4 0.2 1.6e-05 24.7 0.1 1.9 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain zf-CCCH_3 PF15663.5 CRG83282.1 - 0.00017 21.7 0.6 0.00041 20.5 0.6 1.5 1 0 0 1 1 1 1 Zinc-finger containing family Acetyltransf_CG PF14542.6 CRG83282.1 - 0.029 14.5 0.0 0.089 12.9 0.0 1.8 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase zf-CCCH_2 PF14608.6 CRG83282.1 - 0.054 14.0 14.1 0.57 10.7 3.2 2.7 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger TPR_1 PF00515.28 CRG83282.1 - 0.068 13.0 0.1 0.42 10.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat ZapB PF06005.12 CRG83282.1 - 0.27 11.7 4.8 13 6.3 4.8 2.9 1 1 0 1 1 1 0 Cell division protein ZapB TPR_2 PF07719.17 CRG83282.1 - 1.7 9.0 4.7 6.3 7.2 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Helicase_C_2 PF13307.6 CRG83283.1 - 6.2e-57 192.5 0.0 1.4e-56 191.3 0.0 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 CRG83283.1 - 1.8e-50 171.0 0.0 3.2e-50 170.2 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 CRG83283.1 - 8.6e-05 22.6 0.6 0.2 11.7 0.0 2.8 3 1 0 3 3 3 2 Type III restriction enzyme, res subunit HBB PF06777.11 CRG83283.1 - 0.0019 17.9 0.0 0.0042 16.8 0.0 1.5 1 0 0 1 1 1 1 Helical and beta-bridge domain DEAD PF00270.29 CRG83283.1 - 0.0054 16.5 0.3 2.2 8.0 0.0 2.9 2 1 1 3 3 3 2 DEAD/DEAH box helicase AAA_22 PF13401.6 CRG83283.1 - 0.013 15.8 0.0 1.3 9.3 0.0 3.4 3 0 0 3 3 3 0 AAA domain Hydrolase_4 PF12146.8 CRG83284.1 - 0.0057 15.9 0.0 0.087 12.1 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 PLDc PF00614.22 CRG83285.1 - 4.2e-15 55.2 0.2 2.6e-07 30.5 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 CRG83285.1 - 3.7e-13 49.5 0.0 1e-06 28.7 0.0 3.1 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 CRG83285.1 - 1.8e-09 37.6 0.0 1.7e-08 34.4 0.0 2.7 3 1 0 3 3 3 1 PX domain PAS_9 PF13426.7 CRG83286.1 - 1.4e-27 96.0 0.0 2e-17 63.4 0.0 3.3 3 0 0 3 3 3 3 PAS domain PAS_3 PF08447.12 CRG83286.1 - 1.4e-22 79.7 0.0 1.6e-12 47.5 0.0 3.5 3 0 0 3 3 3 3 PAS fold PAS PF00989.25 CRG83286.1 - 8.6e-16 57.9 0.0 1.8e-05 24.7 0.0 3.7 3 1 0 3 3 3 3 PAS fold GATA PF00320.27 CRG83286.1 - 5.7e-15 54.6 10.2 1.1e-14 53.7 10.2 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.10 CRG83286.1 - 2.4e-12 47.1 0.0 0.00018 21.7 0.0 3.4 3 0 0 3 3 3 3 PAS fold PAS_11 PF14598.6 CRG83286.1 - 4.4e-09 36.5 0.0 3.1e-05 24.1 0.0 2.8 3 0 0 3 3 3 2 PAS domain PAS_8 PF13188.7 CRG83286.1 - 0.00083 19.3 0.0 0.055 13.5 0.0 2.4 2 0 0 2 2 2 1 PAS domain PAS_2 PF08446.11 CRG83286.1 - 0.032 14.9 0.0 5.2 7.8 0.0 2.6 2 0 0 2 2 2 0 PAS fold Nudix_N_2 PF14803.6 CRG83286.1 - 0.38 10.7 3.2 0.79 9.7 3.2 1.5 1 0 0 1 1 1 0 Nudix N-terminal Ras PF00071.22 CRG83287.1 - 2.2e-38 131.4 0.1 6.3e-24 84.4 0.0 2.2 1 1 0 2 2 2 2 Ras family Roc PF08477.13 CRG83287.1 - 1.5e-10 41.3 0.1 4.2e-10 39.9 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CRG83287.1 - 0.0058 16.7 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CRG83287.1 - 0.0099 15.3 0.0 0.034 13.6 0.0 1.9 3 0 0 3 3 3 1 ADP-ribosylation factor family Cnn_1N PF07989.11 CRG83288.1 - 2.4e-23 82.1 10.2 2.4e-23 82.1 10.2 12.6 7 1 7 14 14 14 4 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 CRG83288.1 - 3e-19 69.1 28.8 2.2e-16 59.9 18.8 12.1 13 2 2 15 15 15 3 Micro-tubular organiser Mto1 C-term Mto2-binding region Fib_alpha PF08702.10 CRG83288.1 - 0.004 17.3 8.5 0.004 17.3 8.5 7.1 3 1 4 7 7 7 2 Fibrinogen alpha/beta chain family TACC_C PF05010.14 CRG83288.1 - 0.0079 16.0 7.5 0.0079 16.0 7.5 7.4 5 1 4 9 9 9 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2935 PF11155.8 CRG83288.1 - 9.9 6.5 7.9 29 5.0 0.0 4.2 2 1 1 4 4 4 0 Domain of unknown function (DUF2935) QRPTase_C PF01729.19 CRG83289.1 - 2.2e-46 157.7 1.1 4.7e-45 153.4 1.1 2.0 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 CRG83289.1 - 3.7e-23 81.4 0.1 1e-22 79.9 0.0 1.8 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain Aldose_epim PF01263.20 CRG83290.1 - 3.4e-60 203.9 0.3 4e-60 203.7 0.3 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Zn_clus PF00172.18 CRG83291.1 - 2.3e-08 34.0 12.4 3.7e-08 33.3 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Secretin_N_2 PF07655.13 CRG83291.1 - 0.24 12.0 13.4 0.65 10.6 13.4 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 CRG83291.1 - 0.38 9.0 7.4 0.52 8.6 7.4 1.3 1 0 0 1 1 1 0 Menin TMEM171 PF15471.6 CRG83291.1 - 0.87 8.5 7.5 1.3 8.0 7.5 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 EVI2A PF05399.11 CRG83291.1 - 5.6 6.5 9.9 11 5.5 9.9 1.5 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Pterin_4a PF01329.19 CRG83292.1 - 8.3e-18 64.4 0.0 1.1e-17 63.9 0.0 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase PP28 PF10252.9 CRG83293.1 - 1.7e-27 95.7 16.3 1.7e-27 95.7 16.3 3.4 3 1 1 4 4 4 1 Casein kinase substrate phosphoprotein PP28 MFS_1 PF07690.16 CRG83293.1 - 3.5e-26 92.0 46.9 4.4e-25 88.4 36.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-50 PF05216.13 CRG83294.1 - 2.8e-88 295.2 8.5 3.5e-88 294.9 8.5 1.0 1 0 0 1 1 1 1 UNC-50 family Zn_clus PF00172.18 CRG83295.1 - 0.036 14.2 4.2 0.12 12.5 4.2 1.9 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG83296.1 - 1.6e-50 172.0 25.3 1.6e-50 172.0 25.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83296.1 - 2.4e-11 43.2 10.2 2.4e-11 43.2 10.2 1.9 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG83296.1 - 1.3e-07 30.5 4.0 1.3e-07 30.5 4.0 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CRG83296.1 - 0.031 12.7 5.6 0.025 13.0 3.2 1.9 1 1 1 2 2 2 0 Transmembrane secretion effector Sec7 PF01369.20 CRG83297.1 - 1.8e-25 89.7 0.0 3.9e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 CRG83297.1 - 3.1e-20 72.7 0.0 1.8e-19 70.3 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain Lzipper-MIP1 PF14389.6 CRG83297.1 - 0.075 13.3 0.1 0.17 12.2 0.1 1.6 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Glyco_transf_20 PF00982.21 CRG83298.1 - 1.8e-151 505.1 0.0 2.6e-151 504.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CRG83298.1 - 4.3e-81 271.5 0.0 7.6e-81 270.7 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase BRD4_CDT PF17105.5 CRG83298.1 - 0.036 13.7 0.5 0.077 12.6 0.5 1.5 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 PAP_assoc PF03828.19 CRG83299.1 - 0.0013 18.9 0.0 0.006 16.8 0.0 2.1 1 1 0 1 1 1 1 Cid1 family poly A polymerase LETM1 PF07766.13 CRG83300.1 - 4.3e-08 32.8 0.5 8.5e-06 25.3 0.5 2.3 1 1 0 1 1 1 1 LETM1-like protein Isochorismatase PF00857.20 CRG83301.1 - 4.1e-18 66.2 0.0 6.9e-18 65.4 0.0 1.4 1 1 0 1 1 1 1 Isochorismatase family Pkinase PF00069.25 CRG83302.1 - 7.1e-27 94.4 0.0 9e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83302.1 - 2.7e-10 40.0 0.0 3.7e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG83302.1 - 0.034 13.4 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like MFS_1 PF07690.16 CRG83304.1 - 2.1e-13 49.9 27.7 2.1e-13 49.9 27.7 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG83304.1 - 1.6e-06 27.9 7.5 1.6e-06 27.9 7.5 2.5 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 CRG83304.1 - 0.00014 20.9 11.2 0.00014 20.9 11.2 2.1 1 1 1 2 2 2 1 Sugar (and other) transporter TauD PF02668.16 CRG83305.1 - 2.2e-26 93.3 0.0 3e-26 92.8 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PhyH PF05721.13 CRG83306.1 - 2.7e-10 40.9 0.3 7.3e-10 39.5 0.3 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 CRG83306.1 - 2.8e-07 29.7 0.0 0.0001 21.2 0.0 3.0 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_3 PF13640.6 CRG83306.1 - 0.041 14.8 0.0 0.099 13.5 0.0 1.6 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily MFS_1 PF07690.16 CRG83307.1 - 8.8e-24 84.1 47.3 1.6e-20 73.4 29.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Ni_hydr_CYTB PF01292.20 CRG83307.1 - 0.016 14.8 3.0 0.028 14.0 1.5 2.2 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 DUF4405 PF14358.6 CRG83307.1 - 0.72 10.4 10.1 0.13 12.8 4.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) TauD PF02668.16 CRG83308.1 - 5.3e-52 177.3 2.0 6.8e-52 176.9 2.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family FAD_binding_3 PF01494.19 CRG83309.1 - 1.5e-62 211.9 0.0 1.9e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG83309.1 - 1.3e-06 28.3 0.1 0.00025 20.8 0.1 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG83309.1 - 0.00022 20.6 0.5 0.00034 20.0 0.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG83309.1 - 0.0081 16.4 0.0 0.074 13.3 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG83309.1 - 0.02 14.1 0.0 0.045 13.0 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CRG83309.1 - 0.038 14.3 0.4 0.073 13.3 0.4 1.4 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_2 PF00890.24 CRG83309.1 - 0.11 11.6 0.1 0.24 10.4 0.1 1.6 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 CRG83309.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family zf-LITAF-like PF10601.9 CRG83310.1 - 0.00085 19.5 0.2 0.0015 18.8 0.2 1.4 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain Sugar_tr PF00083.24 CRG83311.1 - 7.4e-58 196.5 3.4 1.7e-42 145.9 0.1 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG83311.1 - 1.3e-10 40.8 7.0 2.5e-10 39.8 7.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Colicin_V PF02674.16 CRG83311.1 - 1.5 8.8 6.9 2.4 8.1 0.1 3.0 3 0 0 3 3 3 0 Colicin V production protein GMC_oxred_N PF00732.19 CRG83312.1 - 1.9e-55 188.3 0.0 2.4e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG83312.1 - 3.4e-37 128.1 0.0 5.7e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CRG83312.1 - 3.3e-08 33.0 0.1 2.2e-05 23.7 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CRG83312.1 - 1.5e-06 28.0 0.1 1.7e-05 24.6 0.2 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG83312.1 - 5.9e-05 22.4 0.1 0.00014 21.2 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG83312.1 - 9.4e-05 22.6 0.6 0.00038 20.6 0.5 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG83312.1 - 0.0016 17.6 0.0 0.0024 17.0 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG83312.1 - 0.0017 17.7 0.0 0.71 9.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG83312.1 - 0.0033 16.2 0.1 0.015 14.0 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CRG83312.1 - 0.019 14.0 0.2 0.045 12.8 0.2 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CRG83312.1 - 0.07 12.4 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.18 CRG83312.1 - 0.14 12.0 0.1 0.27 11.1 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CRG83312.1 - 0.18 11.1 0.5 0.32 10.3 0.5 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CRG83312.1 - 0.22 10.3 0.6 0.49 9.2 0.3 1.6 2 0 0 2 2 2 0 Tryptophan halogenase HsbA PF12296.8 CRG83313.1 - 7.7e-17 61.8 9.2 1.2e-16 61.2 9.2 1.3 1 0 0 1 1 1 1 Hydrophobic surface binding protein A Baculo_PEP_C PF04513.12 CRG83313.1 - 0.0013 18.8 1.9 0.092 12.8 0.8 2.1 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 CRG83313.1 - 0.059 13.8 1.8 0.35 11.4 0.7 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TLV_coat PF00429.19 CRG83313.1 - 0.3 9.7 0.8 0.43 9.2 0.8 1.2 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) Lipase_3 PF01764.25 CRG83314.1 - 3.3e-30 104.8 0.0 6.3e-30 103.9 0.0 1.5 2 0 0 2 2 2 1 Lipase (class 3) HsbA PF12296.8 CRG83315.1 - 1.4e-22 80.3 12.1 2.6e-22 79.5 12.1 1.5 1 0 0 1 1 1 1 Hydrophobic surface binding protein A Fungal_trans PF04082.18 CRG83315.1 - 3.7e-19 68.8 0.6 6.5e-19 68.0 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_C41 PF05417.11 CRG83315.1 - 0.019 14.8 0.3 0.038 13.8 0.3 1.4 1 0 0 1 1 1 0 Hepatitis E cysteine protease UCH_1 PF13423.6 CRG83315.1 - 0.055 13.1 0.3 0.093 12.3 0.3 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase ThiF PF00899.21 CRG83315.1 - 0.27 10.6 1.3 6.3 6.1 0.1 2.5 3 0 0 3 3 3 0 ThiF family TauD PF02668.16 CRG83316.1 - 3e-27 96.1 0.0 4e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family 2OG-Fe_Oxy_2 PF10014.9 CRG83316.1 - 0.037 13.8 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 2OG-Fe dioxygenase TSSC4 PF15264.6 CRG83316.1 - 0.061 13.6 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Tumour suppressing sub-chromosomal transferable candidate 4 Glyco_hydro_28 PF00295.17 CRG83317.1 - 1.2e-46 159.3 8.4 2.2e-46 158.4 8.4 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 DUF3024 PF11225.8 CRG83318.1 - 0.17 12.2 4.3 0.36 11.1 4.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3024) Ham1p_like PF01725.16 CRG83319.1 - 2e-37 128.9 0.0 2.4e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Glyco_hydro_3_C PF01915.22 CRG83320.1 - 1.8e-42 145.6 0.0 5.1e-42 144.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG83320.1 - 4.5e-41 141.2 0.0 7.1e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG83320.1 - 1e-25 89.6 0.1 1.8e-25 88.9 0.1 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain APH PF01636.23 CRG83321.1 - 4.4e-11 43.2 0.0 1.4e-10 41.5 0.0 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CRG83321.1 - 0.011 15.4 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 CRG83321.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 CRG83321.1 - 0.053 12.7 0.0 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase CorA PF01544.18 CRG83322.1 - 4.6e-11 42.6 1.8 6.4e-11 42.1 1.8 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ABC2_membrane_3 PF12698.7 CRG83322.1 - 0.0012 18.1 0.4 0.0016 17.6 0.1 1.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ALIX_LYPXL_bnd PF13949.6 CRG83322.1 - 0.036 13.4 0.4 0.062 12.6 0.4 1.4 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV DUF2207 PF09972.9 CRG83322.1 - 0.046 12.5 0.2 0.053 12.3 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3433 PF11915.8 CRG83322.1 - 0.14 12.6 2.2 0.27 11.7 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3433) DUF202 PF02656.15 CRG83322.1 - 2.5 8.6 8.4 5.2 7.6 8.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Asp PF00026.23 CRG83323.1 - 1.7e-69 234.6 4.1 2.2e-69 234.3 4.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG83323.1 - 1.4e-09 38.5 2.6 2.8e-08 34.2 1.4 3.0 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG83323.1 - 0.0003 21.4 5.9 0.39 11.4 0.1 4.1 3 1 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 CRG83323.1 - 0.00072 20.1 0.0 5.5 7.6 0.0 3.7 3 1 0 3 3 3 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 CRG83323.1 - 0.037 13.8 0.1 1.4 8.7 0.1 2.4 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal adh_short PF00106.25 CRG83324.1 - 1.4e-26 93.2 0.3 3e-25 88.8 0.3 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83324.1 - 2.7e-20 72.9 0.3 1.5e-19 70.5 0.3 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83324.1 - 4.2e-07 30.1 1.6 5.5e-07 29.7 0.9 1.5 2 0 0 2 2 2 1 KR domain PALP PF00291.25 CRG83324.1 - 0.0023 17.4 0.1 0.0039 16.6 0.1 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Epimerase PF01370.21 CRG83324.1 - 0.14 11.6 0.7 0.79 9.1 0.7 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF3425 PF11905.8 CRG83325.1 - 2.9e-16 59.6 0.3 9e-16 58.0 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) Selenoprotein_S PF06936.11 CRG83325.1 - 0.0031 17.3 0.5 0.0044 16.9 0.5 1.2 1 0 0 1 1 1 1 Selenoprotein S (SelS) bZIP_Maf PF03131.17 CRG83325.1 - 0.015 15.8 1.9 0.033 14.7 1.9 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor adh_short PF00106.25 CRG83326.1 - 2e-19 69.8 2.8 2.4e-19 69.6 2.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83326.1 - 2.4e-17 63.3 0.5 3.1e-17 62.9 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83326.1 - 6.1e-10 39.3 0.7 8.6e-10 38.8 0.7 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG83326.1 - 0.028 13.9 0.5 0.072 12.5 0.5 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family PhyH PF05721.13 CRG83327.1 - 9.9e-23 81.5 0.0 1.4e-22 81.0 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Amidohydro_1 PF01979.20 CRG83328.1 - 1.3e-14 54.3 0.1 2.6e-14 53.3 0.1 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG83328.1 - 3.5e-07 30.1 4.0 8.4e-06 25.5 0.6 2.4 1 1 1 2 2 2 2 Amidohydrolase family Aa_trans PF01490.18 CRG83329.1 - 1.1e-14 54.0 29.6 1.4e-13 50.3 29.6 2.0 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Orthoreo_P10 PF07204.11 CRG83330.1 - 0.17 11.9 2.6 0.23 11.5 0.3 2.3 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 FAD_binding_4 PF01565.23 CRG83331.1 - 7.5e-22 77.6 2.7 1.5e-21 76.6 2.7 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG83331.1 - 1.2e-13 50.9 0.7 2.2e-13 50.1 0.7 1.5 1 0 0 1 1 1 1 Berberine and berberine like Fucose_iso_C PF02952.17 CRG83331.1 - 0.058 13.1 0.1 0.98 9.1 0.0 2.3 2 0 0 2 2 2 0 L-fucose isomerase, C-terminal domain MFS_1 PF07690.16 CRG83332.1 - 7.9e-41 140.1 31.3 7.9e-41 140.1 31.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83332.1 - 1.5e-06 27.4 8.7 1.5e-06 27.4 8.7 3.4 2 1 0 2 2 2 1 Sugar (and other) transporter DUF697 PF05128.12 CRG83332.1 - 0.22 11.2 0.5 0.46 10.2 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF697) GFO_IDH_MocA PF01408.22 CRG83333.1 - 2.5e-21 76.7 0.1 5.3e-21 75.7 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG83333.1 - 4.1e-07 30.0 0.0 7.7e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Mt_ATP_synt PF15704.5 CRG83333.1 - 0.00011 22.2 0.0 0.00017 21.6 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase subunit NAD_binding_3 PF03447.16 CRG83333.1 - 0.019 15.6 0.0 0.032 14.9 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Glyco_transf_54 PF04666.13 CRG83334.1 - 2.2e-09 36.6 0.0 4.1e-06 25.9 0.0 3.1 2 1 0 2 2 2 2 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region Glyco_transf_25 PF01755.17 CRG83334.1 - 0.047 13.6 0.1 0.078 12.8 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) NAD_binding_2 PF03446.15 CRG83335.1 - 1.8e-25 90.0 0.0 2.7e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG83335.1 - 1.4e-08 35.0 0.4 2.7e-08 34.1 0.1 1.6 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 CRG83335.1 - 0.00085 19.4 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 CRG83335.1 - 0.0015 18.0 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CRG83335.1 - 0.0096 16.5 0.3 0.05 14.2 0.1 2.2 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 CRG83335.1 - 0.11 11.5 0.3 0.43 9.5 0.2 1.8 1 1 1 2 2 2 0 Prephenate dehydrogenase Abhydrolase_1 PF00561.20 CRG83336.1 - 1.9e-22 80.2 0.5 4.3e-22 79.0 0.5 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG83336.1 - 2.3e-17 64.3 0.4 2.9e-17 64.0 0.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG83336.1 - 8.3e-08 31.8 0.0 4.6e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ndr PF03096.14 CRG83336.1 - 7.6e-05 21.5 0.0 0.00011 21.1 0.0 1.2 1 0 0 1 1 1 1 Ndr family MmgE_PrpD PF03972.14 CRG83338.1 - 1.8e-102 343.2 0.2 2.1e-102 342.9 0.2 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Methyltransf_31 PF13847.6 CRG83340.1 - 1.2e-27 96.6 0.0 1.5e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83340.1 - 7.2e-23 81.1 0.1 1.2e-22 80.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83340.1 - 1.2e-21 77.2 0.1 1.9e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG83340.1 - 4.6e-17 62.1 0.0 7.1e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG83340.1 - 7.9e-14 52.2 0.0 1.3e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG83340.1 - 3.9e-13 49.6 0.0 6.3e-13 48.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CRG83340.1 - 8.2e-09 35.3 0.0 1.3e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW PCMT PF01135.19 CRG83340.1 - 5.1e-07 29.7 0.1 7e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 CRG83340.1 - 7.3e-07 28.8 0.0 1.1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 CRG83340.1 - 2.6e-06 27.1 0.0 3.6e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 CRG83340.1 - 0.00013 21.2 0.0 0.0002 20.5 0.0 1.2 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_9 PF08003.11 CRG83340.1 - 0.0002 20.4 0.1 0.037 12.9 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1698) NodS PF05401.11 CRG83340.1 - 0.00037 20.2 0.0 0.00057 19.6 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) RrnaAD PF00398.20 CRG83340.1 - 0.0027 16.8 0.0 0.0037 16.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase CMAS PF02353.20 CRG83340.1 - 0.0072 15.7 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_29 PF03141.16 CRG83340.1 - 0.0075 14.9 0.0 0.01 14.4 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 CRG83340.1 - 0.018 14.9 0.0 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 Hypothetical methyltransferase GidB PF02527.15 CRG83340.1 - 0.025 13.9 0.0 0.039 13.3 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_32 PF13679.6 CRG83340.1 - 0.15 12.0 0.0 0.23 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain NmrA PF05368.13 CRG83341.1 - 1.9e-65 220.7 2.2 2.3e-65 220.4 2.2 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG83341.1 - 3.4e-21 76.0 0.3 4.4e-21 75.6 0.3 1.1 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG83341.1 - 8.5e-07 28.3 0.2 1.3e-06 27.6 0.2 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG83341.1 - 0.0079 15.7 0.6 0.014 14.9 0.3 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Fer2_4 PF13510.6 CRG83341.1 - 0.026 14.6 0.2 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain TrkA_N PF02254.18 CRG83341.1 - 0.03 14.6 0.1 0.078 13.2 0.2 1.8 2 0 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CRG83341.1 - 0.041 14.1 0.7 0.078 13.2 0.7 1.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 CRG83341.1 - 0.071 13.2 0.4 0.21 11.7 0.4 1.8 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 CRG83341.1 - 0.16 12.4 0.6 2 8.8 0.3 2.5 1 1 1 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_hydro_75 PF07335.11 CRG83342.1 - 4.5e-60 202.6 0.4 5.8e-60 202.3 0.4 1.1 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 Glyoxalase PF00903.25 CRG83343.1 - 0.00018 21.7 0.0 0.0003 21.0 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MFS_1 PF07690.16 CRG83344.1 - 1e-26 93.7 26.1 1e-26 93.7 26.1 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Herpes_TAF50 PF03326.13 CRG83345.1 - 0.13 10.9 0.0 0.17 10.5 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) Transp_cyt_pur PF02133.15 CRG83346.1 - 3.7e-14 52.4 41.7 7.5e-14 51.3 41.5 1.6 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Fzo_mitofusin PF04799.13 CRG83346.1 - 0.21 11.1 1.9 0.36 10.4 1.9 1.3 1 0 0 1 1 1 0 fzo-like conserved region Gly_transf_sug PF04488.15 CRG83347.1 - 2.1e-11 44.3 0.1 3.8e-11 43.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Pkinase PF00069.25 CRG83348.1 - 3.5e-12 46.3 0.0 3.8e-12 46.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83348.1 - 2.9e-06 26.8 0.0 3.3e-06 26.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CRG83348.1 - 4.4e-06 26.2 0.0 4.8e-06 26.1 0.0 1.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG83348.1 - 3.5e-05 23.9 0.1 4.8e-05 23.4 0.1 1.3 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG83348.1 - 0.00021 21.0 0.0 0.00031 20.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 CRG83348.1 - 0.015 14.3 0.0 0.016 14.2 0.0 1.0 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 CRG83348.1 - 0.017 14.8 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 RIO1 family Kinase-like PF14531.6 CRG83348.1 - 0.048 13.0 0.0 0.06 12.7 0.0 1.1 1 0 0 1 1 1 0 Kinase-like TMEM189_B_dmain PF10520.9 CRG83348.1 - 0.054 13.6 0.0 0.068 13.3 0.0 1.2 1 0 0 1 1 1 0 B domain of TMEM189, localisation domain NADH-G_4Fe-4S_3 PF10588.9 CRG83348.1 - 0.21 11.1 0.2 0.21 11.1 0.2 1.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Hemopexin PF00045.19 CRG83350.1 - 1e-25 89.4 1.3 1.3e-05 25.0 0.0 4.3 4 0 0 4 4 4 4 Hemopexin DUF4467 PF14729.6 CRG83350.1 - 0.053 13.9 0.0 0.97 9.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) Fungal_trans PF04082.18 CRG83351.1 - 1.3e-13 50.6 0.8 2.6e-13 49.6 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83351.1 - 2.6e-07 30.6 14.1 2.6e-07 30.6 14.1 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pilin PF00114.19 CRG83352.1 - 0.039 14.9 0.5 0.063 14.2 0.5 1.4 1 0 0 1 1 1 0 Pilin (bacterial filament) Fungal_trans PF04082.18 CRG83353.1 - 5.3e-07 28.9 0.7 4.8e-06 25.8 0.4 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83353.1 - 5.3e-06 26.5 13.4 8.7e-06 25.8 13.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_31 PF01055.26 CRG83354.1 - 4e-93 313.0 3.6 6.1e-93 312.4 3.6 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF4968 PF16338.5 CRG83354.1 - 3.1e-05 24.2 0.0 6.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) DUF5110 PF17137.4 CRG83354.1 - 0.0017 18.6 0.0 0.0034 17.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Sugar_tr PF00083.24 CRG83355.1 - 2.4e-81 273.9 20.0 2.8e-81 273.7 20.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83355.1 - 1.5e-16 60.3 26.7 1.5e-16 60.3 26.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG83355.1 - 1.1e-05 24.2 23.2 3.8e-05 22.4 3.4 2.5 3 0 0 3 3 3 2 MFS/sugar transport protein ATG22 PF11700.8 CRG83355.1 - 1.3 7.6 21.4 0.19 10.3 2.9 2.4 2 1 0 2 2 2 0 Vacuole effluxer Atg22 like Wzy_C PF04932.15 CRG83355.1 - 1.6 8.3 9.7 7 6.3 2.0 2.5 2 0 0 2 2 2 0 O-Antigen ligase But2 PF09792.9 CRG83357.1 - 2e-53 180.6 2.8 2e-53 180.6 2.8 1.7 2 0 0 2 2 2 1 Ubiquitin 3 binding protein But2 C-terminal domain RTA1 PF04479.13 CRG83357.1 - 1.1e-14 54.5 4.9 1.5e-14 54.1 4.9 1.1 1 0 0 1 1 1 1 RTA1 like protein TMEM191C PF15194.6 CRG83357.1 - 0.21 11.8 0.4 0.35 11.1 0.4 1.3 1 0 0 1 1 1 0 TMEM191C family RTA1 PF04479.13 CRG83358.1 - 2.1e-72 243.1 6.7 3.1e-72 242.5 6.7 1.2 1 0 0 1 1 1 1 RTA1 like protein Prion_bPrPp PF11587.8 CRG83358.1 - 0.024 14.5 2.6 2.2 8.2 0.5 2.8 2 0 0 2 2 2 0 Major prion protein bPrPp - N terminal Spo7 PF03907.13 CRG83358.1 - 0.32 10.4 1.6 3.8 6.9 0.1 2.1 2 0 0 2 2 2 0 Spo7-like protein MFS_1 PF07690.16 CRG83359.1 - 6.8e-49 166.7 19.5 6.8e-49 166.7 19.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG83359.1 - 2.7e-05 22.8 5.0 4.2e-05 22.2 5.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CRG83359.1 - 0.0011 17.5 1.3 0.0011 17.5 1.3 1.8 2 0 0 2 2 2 1 Transmembrane secretion effector OATP PF03137.20 CRG83359.1 - 0.028 12.7 7.1 0.028 12.7 4.0 2.4 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family GFO_IDH_MocA PF01408.22 CRG83360.1 - 0.0071 17.2 0.0 0.011 16.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG83360.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Glyco_hydro_43 PF04616.14 CRG83361.1 - 4.5e-39 134.5 2.1 5.3e-39 134.2 2.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Fringe PF02434.16 CRG83362.1 - 5.5e-12 45.7 0.0 8.2e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 CRG83362.1 - 0.027 14.3 0.0 0.06 13.2 0.0 1.6 1 1 0 1 1 1 0 Galactosyltransferase PAN_4 PF14295.6 CRG83362.1 - 0.04 13.8 3.0 0.051 13.5 1.7 1.9 2 0 0 2 2 2 0 PAN domain Polysacc_deac_1 PF01522.21 CRG83363.1 - 5.6e-22 77.9 0.0 7.5e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase SIS PF01380.22 CRG83363.1 - 0.18 11.7 0.0 0.41 10.5 0.0 1.6 2 0 0 2 2 2 0 SIS domain AA_permease_2 PF13520.6 CRG83364.1 - 3.5e-35 121.6 17.2 3.5e-35 121.6 17.2 4.1 2 1 1 3 3 3 1 Amino acid permease MFS_1 PF07690.16 CRG83364.1 - 8.1e-12 44.7 36.4 8.1e-12 44.7 36.4 4.4 1 1 2 3 3 3 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG83364.1 - 1.6e-09 37.7 7.8 2e-09 37.3 3.4 3.3 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Amino_oxidase PF01593.24 CRG83365.1 - 6.4e-59 200.4 0.1 3.8e-44 151.7 0.0 2.1 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CRG83365.1 - 9.4e-09 35.4 0.1 2.2e-08 34.2 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG83365.1 - 0.0027 18.2 0.3 0.91 10.1 0.1 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG83365.1 - 0.0037 16.6 0.1 0.026 13.8 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG83365.1 - 0.0051 16.1 0.1 0.013 14.8 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG83365.1 - 0.012 14.9 0.1 0.051 12.8 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 CRG83365.1 - 0.018 14.3 0.2 0.046 13.0 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 CRG83365.1 - 0.032 13.8 0.1 0.078 12.5 0.1 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 CRG83365.1 - 0.081 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CRG83365.1 - 0.68 8.6 2.5 0.28 9.8 0.2 1.5 2 0 0 2 2 2 0 HI0933-like protein Fringe PF02434.16 CRG83366.1 - 5.3e-07 29.3 0.1 4.9e-05 22.9 0.1 3.1 1 1 0 1 1 1 1 Fringe-like PAN_1 PF00024.26 CRG83366.1 - 0.016 15.2 1.3 0.029 14.3 1.3 1.4 1 0 0 1 1 1 0 PAN domain PAN_3 PF08277.12 CRG83366.1 - 0.016 15.0 0.8 0.03 14.1 0.8 1.3 1 0 0 1 1 1 0 PAN-like domain p450 PF00067.22 CRG83367.1 - 1.1e-67 228.8 0.0 1.3e-67 228.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 CRG83368.1 - 3.6e-83 279.9 23.2 4.2e-83 279.7 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83368.1 - 2e-22 79.6 26.4 6.6e-19 68.0 22.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CRG83369.1 - 1.5e-37 129.4 33.6 1.5e-37 129.4 33.6 2.3 3 0 0 3 3 3 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83369.1 - 1e-14 54.3 4.7 1e-14 54.3 4.7 2.9 3 2 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CRG83369.1 - 1e-07 30.8 1.4 1.8e-07 30.0 1.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Spore_YtrH PF14034.6 CRG83369.1 - 0.36 11.0 3.5 0.21 11.8 0.3 2.3 2 0 0 2 2 2 0 Sporulation protein YtrH MFS_1 PF07690.16 CRG83370.1 - 1.7e-20 73.2 41.9 1.3e-19 70.4 20.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG83371.1 - 1.4e-14 53.8 0.1 3.3e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain PD40 PF07676.12 CRG83372.1 - 5.7e-51 169.5 17.9 1.7e-08 34.2 0.3 9.8 9 0 0 9 9 9 9 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 CRG83372.1 - 9.2e-14 51.0 1.9 0.0032 16.3 0.0 6.7 5 1 2 7 7 7 6 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF3748 PF12566.8 CRG83372.1 - 0.00015 21.7 1.5 8.1 6.4 0.0 4.8 4 1 1 6 6 6 2 Protein of unknown function (DUF3748) DUF5050 PF16472.5 CRG83372.1 - 0.00019 20.8 0.0 0.19 10.9 0.0 3.8 3 1 0 3 3 3 2 Domain of unknown function (DUF5050) WD40 PF00400.32 CRG83372.1 - 0.00029 21.6 6.8 17 6.5 0.1 6.5 7 0 0 7 7 7 1 WD domain, G-beta repeat eIF2A PF08662.11 CRG83372.1 - 0.13 12.1 5.2 2.5 7.9 0.0 4.6 5 2 1 6 6 6 0 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 CRG83372.1 - 5.6 6.7 16.4 24 4.7 0.0 6.9 8 0 0 8 8 8 0 Proteasome subunit A N-terminal signature Ank_2 PF12796.7 CRG83373.1 - 2.1e-36 124.4 0.2 5.2e-11 43.0 0.0 8.3 7 1 0 7 7 7 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG83373.1 - 3.9e-30 103.8 4.5 0.00047 20.7 0.1 11.3 10 3 3 13 13 13 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG83373.1 - 7.1e-23 80.4 1.4 0.0037 17.5 0.0 8.4 8 0 0 8 8 8 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83373.1 - 3.6e-20 69.9 3.8 0.0065 16.9 0.0 11.5 12 0 0 12 12 12 3 Ankyrin repeat Ank PF00023.30 CRG83373.1 - 2.7e-15 56.0 10.0 0.0017 18.7 0.0 9.4 9 1 0 9 9 9 4 Ankyrin repeat MFS_1 PF07690.16 CRG83375.1 - 1.2e-23 83.6 48.2 1.2e-23 83.6 48.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 CRG83375.1 - 2.2e-08 34.3 0.1 4.3e-08 33.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG83375.1 - 4.6e-07 30.2 0.1 1.1e-06 29.0 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG83375.1 - 1.2e-05 25.3 0.0 1.9e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ADH_zinc_N PF00107.26 CRG83376.1 - 1.1e-07 31.9 0.1 1.9e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG83376.1 - 1.3e-07 31.5 0.0 2.9e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain MIT PF04212.18 CRG83376.1 - 0.082 13.0 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain PTR2 PF00854.21 CRG83377.1 - 2.4e-75 253.8 4.3 3.6e-75 253.2 4.3 1.2 1 0 0 1 1 1 1 POT family Metallopep PF12044.8 CRG83378.1 - 1.1e-128 429.5 0.0 1.8e-128 428.8 0.0 1.3 1 1 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.6 CRG83378.1 - 0.00061 20.3 0.4 0.002 18.7 0.1 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 CRG83378.1 - 0.0075 16.4 2.2 0.0084 16.3 0.3 2.0 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CRG83378.1 - 0.017 14.8 0.5 0.047 13.3 0.5 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CRG83378.1 - 0.033 14.1 2.2 0.034 14.0 0.6 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 CRG83378.1 - 0.035 13.1 0.1 0.068 12.1 0.1 1.4 1 0 0 1 1 1 0 Peptidase M66 RAI16-like PF10257.9 CRG83379.1 - 5.2e-88 295.3 0.1 7.3e-88 294.8 0.1 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein CBFD_NFYB_HMF PF00808.23 CRG83380.1 - 2.5e-15 56.5 2.9 4e-15 55.9 2.9 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CRG83380.1 - 5.1e-06 26.9 0.1 8.2e-06 26.2 0.0 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 DUF5101 PF17031.5 CRG83380.1 - 0.15 12.1 0.1 0.24 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) zf-C3HC4_3 PF13920.6 CRG83381.1 - 0.0008 19.2 12.3 0.0014 18.4 12.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CRG83381.1 - 1.5 8.8 6.0 2.9 7.9 6.0 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein adh_short_C2 PF13561.6 CRG83382.1 - 1.7e-33 116.2 0.0 2e-33 115.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83382.1 - 4.2e-22 78.6 0.0 5.4e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG83382.1 - 4.3e-09 36.5 0.0 6.3e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG83382.1 - 0.0086 16.0 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 CRG83382.1 - 0.038 14.6 0.0 0.073 13.7 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 CRG83382.1 - 0.058 12.8 0.0 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NAD_binding_7 PF13241.6 CRG83382.1 - 0.084 13.3 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding ADH_N PF08240.12 CRG83383.1 - 7.4e-28 96.6 0.5 1.3e-27 95.8 0.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG83383.1 - 4.7e-14 52.5 0.0 7.3e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG83383.1 - 9.4e-06 25.3 1.4 0.00014 21.4 1.4 2.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus Pyr_redox_2 PF07992.14 CRG83383.1 - 0.0033 16.7 0.2 0.62 9.2 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans_2 PF11951.8 CRG83384.1 - 7.8e-14 51.3 0.7 2.7e-12 46.2 0.1 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83385.1 - 8.6e-09 35.4 12.8 2.2e-08 34.1 12.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Melibiase_2 PF16499.5 CRG83386.1 - 3.3e-49 167.6 0.4 8.3e-49 166.3 0.4 1.7 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 CRG83386.1 - 9.4e-16 57.7 0.2 2.3e-15 56.4 0.2 1.7 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 CRG83386.1 - 0.0041 17.3 0.1 0.028 14.6 0.0 2.4 3 0 0 3 3 3 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase PF02065.18 CRG83386.1 - 0.01 14.8 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Melibiase RTA1 PF04479.13 CRG83387.1 - 2.1e-55 187.6 5.7 3.2e-55 186.9 5.7 1.2 1 0 0 1 1 1 1 RTA1 like protein RTA1 PF04479.13 CRG83388.1 - 2.5e-66 223.2 15.9 2.5e-66 223.2 15.9 1.9 1 1 1 2 2 2 1 RTA1 like protein Zn_clus PF00172.18 CRG83389.1 - 2.3e-09 37.2 9.1 4.5e-09 36.3 9.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG83389.1 - 0.00043 19.2 0.3 0.00043 19.2 0.3 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain MHYT PF03707.16 CRG83390.1 - 8.1e-19 67.5 24.0 7e-12 45.3 0.2 4.7 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat ILVD_EDD PF00920.21 CRG83391.1 - 1.8e-212 706.6 0.4 2.2e-212 706.3 0.4 1.1 1 0 0 1 1 1 1 Dehydratase family Pkinase PF00069.25 CRG83392.1 - 1.5e-38 132.6 0.0 3.7e-37 128.1 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83392.1 - 6.5e-21 74.8 0.0 1.1e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Tim17 PF02466.19 CRG83393.1 - 8.3e-27 93.8 6.7 1.2e-26 93.3 6.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2428 PF10350.9 CRG83394.1 - 1.6e-62 211.3 0.0 4.1e-62 209.9 0.0 1.8 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 CRG83394.1 - 0.0091 16.2 7.0 18 5.9 0.0 6.6 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 CRG83394.1 - 0.059 13.9 5.6 5.5 7.6 0.1 4.8 6 0 0 6 6 6 0 HEAT-like repeat AbiH PF14253.6 CRG83394.1 - 0.15 11.9 0.1 0.81 9.5 0.0 2.1 2 0 0 2 2 2 0 Bacteriophage abortive infection AbiH HEAT_2 PF13646.6 CRG83394.1 - 0.95 9.9 3.4 9.2 6.7 0.0 3.9 4 0 0 4 4 4 0 HEAT repeats ResB PF05140.14 CRG83395.1 - 0.011 14.5 0.1 0.016 14.0 0.1 1.2 1 0 0 1 1 1 0 ResB-like family PTase_Orf2 PF11468.8 CRG83396.1 - 2.8e-90 302.6 0.0 3.2e-90 302.4 0.0 1.0 1 0 0 1 1 1 1 Aromatic prenyltransferase Orf2 UCH PF00443.29 CRG83397.1 - 2.4e-67 227.2 0.0 4.2e-67 226.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PX PF00787.24 CRG83397.1 - 1.6e-17 63.5 0.0 7.3e-17 61.4 0.0 2.2 1 0 0 1 1 1 1 PX domain DUSP PF06337.12 CRG83397.1 - 1.3e-13 51.4 0.0 3e-13 50.2 0.0 1.7 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 CRG83397.1 - 1.9e-06 27.7 0.0 0.046 13.3 0.0 2.9 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Vps5 PF09325.10 CRG83397.1 - 2.3e-05 24.1 7.0 0.016 14.8 0.9 2.6 2 0 0 2 2 2 2 Vps5 C terminal like USP7_C2 PF14533.6 CRG83397.1 - 0.00051 19.8 0.0 0.0084 15.8 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal Peptidase_C10 PF01640.17 CRG83397.1 - 0.07 13.4 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase C10 family DUF4604 PF15377.6 CRG83398.1 - 0.054 13.9 0.1 0.12 12.8 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) SR-25 PF10500.9 CRG83398.1 - 0.56 9.8 22.8 1 8.9 22.8 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein QWRF PF04484.12 CRG83398.1 - 0.62 9.7 8.5 0.94 9.2 8.5 1.2 1 0 0 1 1 1 0 QWRF family CCDC106 PF15794.5 CRG83398.1 - 1.2 8.8 6.5 1.9 8.2 6.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 IMUP PF15761.5 CRG83398.1 - 3.1 8.5 13.4 7 7.4 13.4 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF3446 PF11928.8 CRG83398.1 - 3.9 7.8 20.9 0.23 11.8 15.4 1.8 2 0 0 2 2 2 0 Early growth response N-terminal domain Mlf1IP PF10248.9 CRG83398.1 - 5.8 6.8 7.1 9.5 6.2 7.1 1.2 1 0 0 1 1 1 0 Myelodysplasia-myeloid leukemia factor 1-interacting protein Epimerase PF01370.21 CRG83399.1 - 4.5e-10 39.4 0.5 6.5e-05 22.5 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG83399.1 - 6.4e-07 29.4 0.6 1.1e-06 28.6 0.6 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG83399.1 - 1.6e-05 24.6 0.1 2.5e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Semialdhyde_dh PF01118.24 CRG83399.1 - 0.00032 21.1 0.1 0.00097 19.6 0.1 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CRG83399.1 - 0.00043 19.4 0.0 0.14 11.1 0.0 2.4 2 1 1 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family DUF4859 PF16151.5 CRG83399.1 - 0.066 13.1 2.0 0.097 12.6 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4859) GDP_Man_Dehyd PF16363.5 CRG83399.1 - 0.11 11.9 0.2 8.3 5.7 0.0 2.6 1 1 2 3 3 3 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG83399.1 - 0.19 10.9 0.0 0.41 9.8 0.0 1.5 1 0 0 1 1 1 0 Male sterility protein PRK PF00485.18 CRG83400.1 - 9.9e-11 41.7 0.0 1.3e-10 41.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CRG83400.1 - 9.2e-05 23.0 0.1 0.00016 22.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 CRG83400.1 - 0.001 19.0 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG83400.1 - 0.0013 19.2 0.0 0.0021 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CRG83400.1 - 0.0018 17.5 0.0 0.0027 16.9 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 CRG83400.1 - 0.0027 17.9 0.0 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CRG83400.1 - 0.0093 16.4 0.1 0.041 14.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CRG83400.1 - 0.011 16.1 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CRG83400.1 - 0.011 15.0 0.3 0.024 13.9 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_28 PF13521.6 CRG83400.1 - 0.013 15.8 0.2 0.03 14.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CRG83400.1 - 0.015 15.3 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 CRG83400.1 - 0.017 14.9 0.0 1.1 9.0 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Viral_helicase1 PF01443.18 CRG83400.1 - 0.019 14.7 0.0 0.032 14.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 CRG83400.1 - 0.037 14.3 0.0 0.073 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CRG83400.1 - 0.04 14.3 0.0 0.057 13.9 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 CRG83400.1 - 0.045 13.0 0.0 0.051 12.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CRG83400.1 - 0.047 13.3 0.0 0.097 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 CRG83400.1 - 0.047 13.0 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_30 PF13604.6 CRG83400.1 - 0.052 13.3 0.0 0.086 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CRG83400.1 - 0.06 13.2 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NTPase MMR_HSR1 PF01926.23 CRG83400.1 - 0.079 13.0 0.1 0.9 9.6 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_11 PF13086.6 CRG83400.1 - 0.098 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CRG83400.1 - 0.1 13.1 0.1 0.44 11.1 0.0 1.9 2 0 0 2 2 2 0 ABC transporter KTI12 PF08433.10 CRG83400.1 - 0.11 11.9 0.1 0.2 11.1 0.0 1.4 2 0 0 2 2 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 CRG83400.1 - 0.15 11.7 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CRG83400.1 - 0.16 12.4 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 CRG83400.1 - 0.21 11.6 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Con-6 PF10346.9 CRG83401.1 - 2.1e-27 94.8 0.1 3.5e-15 55.7 0.0 2.1 2 0 0 2 2 2 2 Conidiation protein 6 Glyco_hydro_16 PF00722.21 CRG83403.1 - 1.3e-09 37.7 0.1 1.2e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 CVNH PF08881.10 CRG83404.1 - 8.7e-12 45.6 1.2 1.1e-11 45.3 1.2 1.1 1 0 0 1 1 1 1 CVNH domain Mob_synth_C PF06463.13 CRG83404.1 - 0.11 12.5 0.4 0.14 12.1 0.4 1.2 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C Amidohydro_3 PF07969.11 CRG83405.1 - 1.6e-49 169.6 4.7 2.4e-49 169.1 4.7 1.2 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CRG83405.1 - 1.3e-14 54.3 3.7 4.2e-13 49.3 0.6 2.3 2 0 0 2 2 2 2 Amidohydrolase family PaaX PF07848.12 CRG83405.1 - 0.068 13.4 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 PaaX-like protein Glyoxalase PF00903.25 CRG83406.1 - 3.5e-06 27.2 0.0 7.4e-06 26.2 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Lipase_3 PF01764.25 CRG83408.1 - 6.5e-20 71.4 0.0 1.4e-19 70.3 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CRG83408.1 - 0.0014 19.3 0.3 0.0014 19.3 0.3 2.3 1 1 0 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CRG83408.1 - 0.01 15.5 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Chlorophyllase2 PF12740.7 CRG83408.1 - 0.095 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Hydrolase_4 PF12146.8 CRG83408.1 - 0.14 11.4 0.0 0.96 8.7 0.0 2.0 2 0 0 2 2 2 0 Serine aminopeptidase, S33 SCIMP PF15050.6 CRG83408.1 - 0.14 12.6 0.2 0.29 11.6 0.2 1.5 1 0 0 1 1 1 0 SCIMP protein TGBp3 PF02495.17 CRG83408.1 - 0.18 11.5 0.3 0.93 9.2 0.0 2.1 2 0 0 2 2 2 0 Triple gene block 3 MFS_1 PF07690.16 CRG83409.1 - 1.1e-28 100.1 27.8 2.9e-28 98.8 16.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83409.1 - 1.3e-06 27.6 8.4 1.3e-06 27.6 8.4 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 CRG83409.1 - 0.12 11.2 12.1 0.0099 14.8 5.4 2.2 3 0 0 3 3 3 0 MFS_1 like family MFS_1 PF07690.16 CRG83410.1 - 2.5e-15 56.3 18.6 2.5e-15 56.3 18.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily CENP-F_leu_zip PF10473.9 CRG83411.1 - 6e-05 23.1 1.9 5.9 6.9 0.1 4.5 1 1 3 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Takusan PF04822.13 CRG83411.1 - 0.00012 21.9 27.7 1.9 8.4 0.8 6.9 1 1 7 8 8 8 7 Takusan Nsp1_C PF05064.13 CRG83411.1 - 0.00017 21.3 7.2 0.98 9.2 0.1 4.7 1 1 4 5 5 5 3 Nsp1-like C-terminal region GAS PF13851.6 CRG83411.1 - 0.00062 19.2 9.8 0.091 12.1 0.8 3.4 1 1 3 4 4 4 4 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.22 CRG83411.1 - 0.02 15.1 1.0 7.5 6.8 0.1 2.6 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain THOC7 PF05615.13 CRG83411.1 - 0.22 11.8 7.3 48 4.2 0.1 4.5 1 1 4 6 6 6 0 Tho complex subunit 7 DUF995 PF06191.12 CRG83411.1 - 1.9 8.1 20.4 27 4.4 0.2 6.1 1 1 5 7 7 7 0 Protein of unknown function (DUF995) GATase_7 PF13537.6 CRG83411.1 - 2.6 8.0 24.3 43 4.0 0.5 7.3 2 2 7 9 9 9 0 Glutamine amidotransferase domain DUF3328 PF11807.8 CRG83412.1 - 2.1e-58 197.7 1.5 3.4e-58 197.0 1.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF1996 PF09362.10 CRG83412.1 - 0.0046 17.0 0.0 0.0073 16.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Amidohydro_1 PF01979.20 CRG83414.1 - 4.3e-23 82.2 0.0 7.3e-23 81.4 0.0 1.4 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG83414.1 - 1.4e-16 61.0 2.2 1e-09 38.5 0.1 2.8 2 1 0 2 2 2 2 Amidohydrolase family PE-PPE PF08237.11 CRG83414.1 - 0.00015 21.4 0.0 0.00026 20.6 0.0 1.3 1 0 0 1 1 1 1 PE-PPE domain DUF1899 PF08953.11 CRG83415.1 - 6.7e-36 122.0 0.0 1.3e-35 121.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 CRG83415.1 - 8e-22 76.9 0.1 1.6e-21 75.9 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 CRG83415.1 - 1.2e-15 57.6 8.0 0.0011 19.7 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG83415.1 - 9.6e-05 22.6 0.0 1.3 9.4 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain HMMR_N PF15905.5 CRG83415.1 - 0.014 14.9 0.0 0.018 14.6 0.0 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DivIC PF04977.15 CRG83415.1 - 0.032 14.0 1.4 0.032 14.0 1.4 1.7 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 CRG83415.1 - 0.29 11.8 2.2 0.3 11.7 0.7 1.8 2 0 0 2 2 2 0 SlyX Kinesin PF00225.23 CRG83416.1 - 3.6e-103 345.0 0.1 3.6e-103 345.0 0.1 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CRG83416.1 - 1.6e-59 200.2 0.0 1.6e-59 200.2 0.0 2.4 2 1 0 2 2 2 1 Microtubule binding Bac_DnaA PF00308.18 CRG83416.1 - 0.039 13.8 0.0 0.039 13.8 0.0 2.5 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_16 PF13191.6 CRG83416.1 - 0.052 13.9 0.0 0.052 13.9 0.0 3.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 CRG83416.1 - 0.06 13.1 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain Herpes_US12 PF05363.12 CRG83416.1 - 0.08 13.7 1.2 0.2 12.4 0.1 2.4 3 0 0 3 3 3 0 Herpesvirus US12 family AAA_22 PF13401.6 CRG83416.1 - 0.27 11.5 2.9 0.54 10.5 0.0 2.8 2 1 0 2 2 2 0 AAA domain Filament PF00038.21 CRG83416.1 - 0.33 10.5 44.4 1.1 8.8 19.9 4.8 2 1 2 4 4 4 0 Intermediate filament protein Fez1 PF06818.15 CRG83416.1 - 5.1 7.5 44.4 3 8.3 9.0 3.6 2 1 1 3 3 3 0 Fez1 Tweety PF04906.13 CRG83417.1 - 0.0078 14.9 2.8 0.0078 14.9 2.8 1.6 2 0 0 2 2 2 1 Tweety DUF4112 PF13430.6 CRG83417.1 - 1.4 9.2 5.4 4.3 7.7 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4112) p450 PF00067.22 CRG83418.1 - 8.6e-64 216.0 0.0 1e-63 215.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_10 PF13460.6 CRG83419.1 - 2.1e-07 31.0 0.0 2.9e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG83419.1 - 5.4e-05 22.8 0.0 0.0031 17.0 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG83419.1 - 0.0027 16.7 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 CRG83419.1 - 0.0036 17.5 0.0 0.0052 17.0 0.0 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 CRG83419.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family Semialdhyde_dh PF01118.24 CRG83419.1 - 0.064 13.7 0.0 0.17 12.3 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CRG83419.1 - 0.075 13.2 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.12 CRG83419.1 - 0.15 11.2 0.0 0.49 9.5 0.0 1.8 2 0 0 2 2 2 0 Male sterility protein adh_short PF00106.25 CRG83420.1 - 1.1e-30 106.5 0.2 1.9e-30 105.8 0.2 1.4 1 0 0 1 1 1 1 short chain dehydrogenase FAD_binding_4 PF01565.23 CRG83420.1 - 1.2e-20 73.7 3.0 1.5e-20 73.4 0.7 2.4 3 0 0 3 3 3 1 FAD binding domain adh_short_C2 PF13561.6 CRG83420.1 - 6.1e-20 71.8 0.3 1.4e-19 70.6 0.3 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83420.1 - 4.7e-07 29.9 0.2 1.3e-06 28.4 0.1 1.7 2 0 0 2 2 2 1 KR domain BBE PF08031.12 CRG83420.1 - 3e-05 24.0 0.2 3e-05 24.0 0.2 2.0 2 0 0 2 2 2 1 Berberine and berberine like Epimerase PF01370.21 CRG83420.1 - 0.011 15.1 0.1 0.019 14.5 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GA-like PF17573.2 CRG83420.1 - 0.13 12.2 0.3 0.28 11.1 0.3 1.5 1 0 0 1 1 1 0 GA-like domain 2OG-FeII_Oxy PF03171.20 CRG83421.1 - 1.1e-06 29.1 0.0 2.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG83421.1 - 0.0004 21.1 0.0 0.00075 20.2 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal ketoacyl-synt PF00109.26 CRG83422.1 - 2e-60 204.5 0.2 3.5e-60 203.7 0.2 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG83422.1 - 1.9e-58 198.1 0.0 3e-58 197.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CRG83422.1 - 4.3e-53 179.9 0.0 8.5e-53 178.9 0.0 1.5 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CRG83422.1 - 3.5e-51 174.6 0.0 6.6e-51 173.7 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG83422.1 - 1.7e-33 115.1 0.0 4.7e-33 113.7 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG83422.1 - 1.4e-22 80.3 0.0 3.6e-22 78.9 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 CRG83422.1 - 9.8e-20 71.2 0.0 2.7e-19 69.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG83422.1 - 3.2e-11 43.3 0.0 1.2e-10 41.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83422.1 - 4.4e-11 43.3 0.0 1.8e-10 41.4 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83422.1 - 4e-09 37.0 0.0 1.3e-08 35.4 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG83422.1 - 1.8e-08 34.3 0.0 4.5e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CRG83422.1 - 2.2e-08 34.3 1.8 5.7e-08 33.0 0.0 2.6 3 0 0 3 3 2 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.18 CRG83422.1 - 0.0033 16.8 0.0 0.0068 15.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family SAT PF16073.5 CRG83422.1 - 0.011 15.5 0.5 1 9.0 0.2 2.7 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis adh_short PF00106.25 CRG83422.1 - 0.039 13.4 0.1 0.26 10.7 0.1 2.5 2 1 0 2 2 2 0 short chain dehydrogenase DUF829 PF05705.14 CRG83423.1 - 1.9e-59 201.5 0.2 2.2e-59 201.3 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Glyco_hydro_cc PF11790.8 CRG83425.1 - 7.7e-76 254.8 0.8 1.4e-75 254.0 0.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_16 PF00722.21 CRG83425.1 - 3.3e-16 59.2 0.3 6.5e-16 58.3 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_trans_2_3 PF13632.6 CRG83426.1 - 1.4e-52 178.5 1.2 1.4e-52 178.5 1.2 2.7 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CRG83426.1 - 0.0096 15.7 0.0 0.026 14.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 RIC3 PF15361.6 CRG83427.1 - 0.0032 17.8 0.0 0.0041 17.5 0.0 1.3 1 0 0 1 1 1 1 Resistance to inhibitors of cholinesterase homologue 3 DUF1180 PF06679.12 CRG83427.1 - 0.049 14.1 1.4 0.054 13.9 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Imm45 PF15572.6 CRG83428.1 - 0.12 12.8 0.7 0.23 11.9 0.7 1.6 1 1 0 1 1 1 0 Immunity protein 45 ADH_zinc_N PF00107.26 CRG83429.1 - 1.3e-05 25.2 0.1 1.5e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase WD40 PF00400.32 CRG83430.1 - 6.7e-45 150.2 30.4 2.8e-07 31.1 0.7 8.4 7 1 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 CRG83430.1 - 1.4e-14 53.7 0.2 2.6e-14 52.8 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG83430.1 - 1.8e-11 43.6 0.1 3.9e-11 42.5 0.1 1.6 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 CRG83430.1 - 1.9e-07 31.3 0.1 0.0093 16.2 0.0 4.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG83430.1 - 2.5e-07 29.7 8.1 0.31 9.7 0.4 5.7 6 1 1 7 7 7 4 Nucleoporin Nup120/160 F-box_4 PF15966.5 CRG83430.1 - 0.0037 17.1 0.2 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 F-box APG17 PF04108.12 CRG83431.1 - 2.3e-135 451.8 1.3 2.7e-135 451.5 1.3 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 FAP206 PF12018.8 CRG83431.1 - 7e-05 22.5 0.3 0.0042 16.6 0.0 2.9 3 0 0 3 3 3 1 Domain of unknown function Miga PF10265.9 CRG83431.1 - 0.0099 14.9 3.9 0.019 14.0 3.9 1.5 1 0 0 1 1 1 1 Mitoguardin Med4 PF10018.9 CRG83431.1 - 0.026 14.2 2.5 15 5.2 0.2 3.7 3 1 0 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 Sec5 PF15469.6 CRG83431.1 - 0.033 14.0 3.5 1.1 9.0 0.1 3.4 4 1 0 4 4 3 0 Exocyst complex component Sec5 COG5 PF10392.9 CRG83431.1 - 0.045 13.9 3.9 13 5.9 0.1 4.3 4 0 0 4 4 4 0 Golgi transport complex subunit 5 Snapin_Pallidin PF14712.6 CRG83431.1 - 0.052 14.0 8.6 0.18 12.2 0.3 4.0 5 1 0 5 5 3 0 Snapin/Pallidin DUF4358 PF14270.6 CRG83431.1 - 0.06 13.6 0.6 0.19 12.0 0.2 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4358) GCP_N_terminal PF17681.1 CRG83431.1 - 0.069 12.8 0.1 9.4 5.8 0.0 2.3 1 1 1 2 2 2 0 Gamma tubulin complex component N-terminal BAR PF03114.18 CRG83431.1 - 0.096 12.3 0.3 5.1 6.7 0.1 3.4 3 1 0 3 3 3 0 BAR domain ApoLp-III PF07464.11 CRG83431.1 - 0.13 12.4 0.9 23 5.1 0.0 3.6 4 0 0 4 4 4 0 Apolipophorin-III precursor (apoLp-III) HsbA PF12296.8 CRG83431.1 - 0.15 12.5 0.2 4.6 7.7 0.0 2.7 2 0 0 2 2 2 0 Hydrophobic surface binding protein A FapA PF03961.13 CRG83431.1 - 0.16 10.5 0.3 0.36 9.4 0.1 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A Baculo_PEP_C PF04513.12 CRG83431.1 - 0.21 11.6 3.0 4.7 7.3 0.9 3.6 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus SF-assemblin PF06705.11 CRG83431.1 - 0.22 10.9 10.4 11 5.3 0.1 4.6 4 1 0 5 5 5 0 SF-assemblin/beta giardin WXG100 PF06013.12 CRG83431.1 - 0.3 11.4 8.0 1.1 9.5 0.3 4.6 4 1 0 5 5 5 0 Proteins of 100 residues with WXG RasGAP_C PF03836.15 CRG83431.1 - 0.3 11.2 6.6 8.9 6.5 0.1 4.5 4 1 0 4 4 4 0 RasGAP C-terminus Tropomyosin_1 PF12718.7 CRG83431.1 - 0.43 10.7 8.2 0.57 10.3 0.1 3.9 4 0 0 4 4 4 0 Tropomyosin like SlyX PF04102.12 CRG83431.1 - 0.44 11.2 2.5 19 6.0 0.0 3.8 5 0 0 5 5 3 0 SlyX HBM PF16591.5 CRG83431.1 - 0.49 9.8 5.0 0.23 10.9 0.2 2.9 4 1 1 5 5 5 0 Helical bimodular sensor domain DUF4795 PF16043.5 CRG83431.1 - 1.3 8.5 4.1 1.5 8.4 0.1 2.7 2 2 1 3 3 3 0 Domain of unknown function (DUF4795) CC2-LZ PF16516.5 CRG83431.1 - 1.5 9.2 6.4 7.3 7.0 0.1 3.9 4 0 0 4 4 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YabA PF06156.13 CRG83431.1 - 3.4 8.3 5.5 13 6.5 0.0 3.7 4 1 1 5 5 4 0 Initiation control protein YabA DUF1664 PF07889.12 CRG83431.1 - 5.4 7.1 9.3 18 5.4 0.0 4.3 5 1 0 6 6 4 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 CRG83431.1 - 5.6 7.6 9.7 2.3e+02 2.4 5.6 4.3 2 2 0 2 2 2 0 Syntaxin 6, N-terminal Ank_2 PF12796.7 CRG83432.1 - 2.3e-136 444.7 28.5 5e-16 59.1 0.2 15.5 1 1 16 17 17 17 17 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG83432.1 - 5.9e-98 320.1 28.6 1e-09 38.8 0.0 20.0 9 6 11 21 21 21 20 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83432.1 - 2.7e-89 282.3 36.2 2.2e-05 24.5 0.0 28.0 28 1 1 29 29 29 21 Ankyrin repeat Ank_5 PF13857.6 CRG83432.1 - 1e-88 290.2 37.6 1.9e-10 40.7 0.0 22.2 9 8 14 23 23 23 18 Ankyrin repeats (many copies) Ank PF00023.30 CRG83432.1 - 7.9e-65 212.7 59.0 4.1e-05 23.8 0.2 26.1 25 2 2 27 27 27 17 Ankyrin repeat SPRY PF00622.28 CRG83432.1 - 3.3e-16 59.5 0.6 3.1e-15 56.3 0.7 2.2 2 0 0 2 2 2 1 SPRY domain Peptidase_S8 PF00082.22 CRG83434.1 - 8.7e-13 48.2 0.3 1.7e-12 47.3 0.3 1.4 1 0 0 1 1 1 1 Subtilase family Cpn60_TCP1 PF00118.24 CRG83434.1 - 0.21 10.1 0.1 1.1 7.8 0.0 1.9 2 0 0 2 2 2 0 TCP-1/cpn60 chaperonin family RIO1 PF01163.22 CRG83435.1 - 1.8e-71 239.6 0.1 1.8e-71 239.6 0.1 1.5 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 CRG83435.1 - 0.0072 15.7 0.1 0.041 13.2 0.1 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG83435.1 - 0.012 15.5 0.0 0.3 11.0 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family YL1 PF05764.13 CRG83435.1 - 7.6 6.6 21.6 7.9 6.5 6.6 2.2 2 0 0 2 2 2 0 YL1 nuclear protein SMC_N PF02463.19 CRG83436.1 - 2.4e-72 243.0 0.0 3.7e-72 242.3 0.0 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CRG83436.1 - 3.4e-31 108.0 0.1 1.9e-30 105.6 0.0 2.5 3 0 0 3 3 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 CRG83436.1 - 2e-18 67.7 2.6 2e-18 67.7 2.6 7.3 2 2 2 4 4 3 1 AAA domain AAA_21 PF13304.6 CRG83436.1 - 3.4e-17 63.2 12.1 3.6e-11 43.4 0.1 4.0 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CRG83436.1 - 1e-13 51.7 58.3 6.5e-08 32.7 26.1 4.7 2 2 1 3 3 3 2 AAA ATPase domain FlaC_arch PF05377.11 CRG83436.1 - 0.0047 17.3 2.3 0.0047 17.3 2.3 10.4 12 2 2 14 14 13 3 Flagella accessory protein C (FlaC) AAA_29 PF13555.6 CRG83436.1 - 0.0049 16.6 0.0 0.012 15.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Filament PF00038.21 CRG83436.1 - 0.0054 16.4 12.9 0.0054 16.4 12.9 5.3 2 2 2 4 4 3 1 Intermediate filament protein APG6_N PF17675.1 CRG83436.1 - 0.25 11.9 121.7 0.43 11.1 6.6 9.2 3 3 7 10 10 10 0 Apg6 coiled-coil region ABC_tran PF00005.27 CRG83436.1 - 0.36 11.3 0.0 0.36 11.3 0.0 6.5 3 2 0 4 4 3 0 ABC transporter Spc7 PF08317.11 CRG83436.1 - 1.8 7.4 109.7 0.26 10.1 12.2 7.3 2 2 4 7 7 7 0 Spc7 kinetochore protein DUF87 PF01935.17 CRG83436.1 - 2.8 8.0 0.0 2.8 8.0 0.0 6.6 3 2 1 5 5 3 0 Helicase HerA, central domain AAA_13 PF13166.6 CRG83436.1 - 4.1 5.9 86.3 0.059 12.0 8.5 6.3 3 2 2 6 6 6 0 AAA domain HsbA PF12296.8 CRG83436.1 - 7.1 7.1 21.7 2.2 8.7 0.8 6.4 7 1 0 7 7 7 0 Hydrophobic surface binding protein A DUF3605 PF12239.8 CRG83437.1 - 2.3e-59 200.1 0.1 2.8e-59 199.8 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) FAD_binding_6 PF00970.24 CRG83438.1 - 1.1e-32 112.4 0.0 1.9e-32 111.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CRG83438.1 - 3.8e-27 95.1 0.0 5.8e-27 94.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 CRG83438.1 - 1e-06 29.0 0.0 0.00013 22.1 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 CRG83438.1 - 0.017 15.3 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain PIP5K PF01504.18 CRG83439.1 - 9.3e-40 136.6 0.0 7e-38 130.4 0.0 2.0 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase tRNA-synt_1d PF00750.19 CRG83440.1 - 1.6e-97 326.6 6.4 4.4e-96 321.9 6.4 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (R) NAD_binding_4 PF07993.12 CRG83440.1 - 2.8e-36 125.0 0.0 4.6e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG83440.1 - 2.4e-29 102.2 0.0 7.5e-29 100.6 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme DALR_1 PF05746.15 CRG83440.1 - 6.1e-27 94.2 0.0 2e-26 92.5 0.0 2.0 1 0 0 1 1 1 1 DALR anticodon binding domain Epimerase PF01370.21 CRG83440.1 - 2e-09 37.2 0.0 4.5e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Arg_tRNA_synt_N PF03485.16 CRG83440.1 - 4.7e-06 27.1 0.0 1.2e-05 25.8 0.0 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain PP-binding PF00550.25 CRG83440.1 - 0.00013 22.3 0.1 0.00029 21.2 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site YabA PF06156.13 CRG83440.1 - 0.061 14.0 3.0 0.05 14.2 0.7 2.0 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 CRG83440.1 - 2.4 8.0 6.8 1.1 9.0 1.3 2.4 2 0 0 2 2 2 0 Septum formation initiator MFS_1 PF07690.16 CRG83442.1 - 4.2e-28 98.3 48.2 2e-17 63.2 24.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 CRG83442.1 - 8.2 4.9 16.3 0.017 13.8 1.2 2.9 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like FAD_binding_3 PF01494.19 CRG83444.1 - 1.5e-23 83.6 0.0 2.1e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain ADC PF06314.11 CRG83444.1 - 4.4e-08 33.0 0.1 1.2e-07 31.5 0.1 1.8 1 1 0 1 1 1 1 Acetoacetate decarboxylase (ADC) Pyr_redox_2 PF07992.14 CRG83444.1 - 8.1e-08 31.8 1.5 7e-05 22.2 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG83444.1 - 3.8e-06 27.1 1.4 9.7e-06 25.7 0.7 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG83444.1 - 0.00018 20.8 2.0 0.00018 20.8 2.0 1.8 1 1 1 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 CRG83444.1 - 0.0011 17.9 0.6 0.022 13.6 0.9 2.3 2 1 1 3 3 3 1 Tryptophan halogenase DAO PF01266.24 CRG83444.1 - 0.0017 18.0 5.3 0.0054 16.4 2.7 2.1 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG83444.1 - 0.0044 17.5 1.2 0.056 14.0 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG83444.1 - 0.0098 15.3 0.6 0.017 14.5 0.6 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG83444.1 - 0.011 15.8 0.9 0.024 14.6 0.2 2.0 2 1 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 CRG83444.1 - 0.011 14.4 1.1 0.011 14.4 1.1 1.5 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 CRG83444.1 - 0.025 13.7 0.5 0.041 13.0 0.5 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CRG83444.1 - 0.028 13.7 0.1 0.051 12.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CRG83444.1 - 0.029 13.6 0.0 0.087 12.1 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CRG83444.1 - 0.13 11.5 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Epimerase PF01370.21 CRG83445.1 - 5.2e-18 65.4 0.0 3.8e-17 62.6 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG83445.1 - 1.5e-11 43.8 0.0 2.6e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG83445.1 - 6.9e-09 35.9 0.0 1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG83445.1 - 4.9e-06 26.2 0.1 3.6e-05 23.3 0.0 2.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG83445.1 - 2.6e-05 23.5 0.3 4.4e-05 22.7 0.0 1.5 2 0 0 2 2 2 1 RmlD substrate binding domain adh_short PF00106.25 CRG83445.1 - 0.00034 20.1 0.6 0.0019 17.7 0.6 2.0 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CRG83445.1 - 0.00035 19.8 0.2 0.00087 18.5 0.2 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein DapB_N PF01113.20 CRG83445.1 - 0.0035 17.5 0.0 0.0074 16.4 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 CRG83445.1 - 0.0058 17.1 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 CRG83445.1 - 0.12 11.9 0.2 0.71 9.4 0.2 2.2 2 1 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 CRG83445.1 - 0.15 12.4 0.0 0.33 11.2 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Flavin_Reduct PF01613.18 CRG83446.1 - 1.3e-17 64.3 0.0 1.7e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Sugar_tr PF00083.24 CRG83447.1 - 2.6e-56 191.4 4.7 3.7e-56 190.9 4.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83447.1 - 6.3e-21 74.7 11.0 9.8e-21 74.0 11.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Epimerase PF01370.21 CRG83447.1 - 7.5e-08 32.1 0.0 4.2e-07 29.7 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG83447.1 - 2.6e-07 30.0 0.0 0.00043 19.4 0.0 2.0 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG83447.1 - 4.9e-05 23.3 0.0 0.00052 20.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG83447.1 - 0.0027 17.2 0.0 0.0071 15.8 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CRG83447.1 - 0.003 17.1 0.0 2.5 7.6 0.0 2.4 2 0 0 2 2 2 2 NmrA-like family Phage_Gp19 PF09355.10 CRG83447.1 - 0.043 14.2 0.0 0.098 13.1 0.0 1.6 1 0 0 1 1 1 0 Phage protein Gp19/Gp15/Gp42 MFS_2 PF13347.6 CRG83447.1 - 0.43 9.1 7.9 1 7.8 7.9 1.6 1 1 0 1 1 1 0 MFS/sugar transport protein Cupin_2 PF07883.11 CRG83448.1 - 2.2e-09 36.9 0.0 3.2e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CRG83448.1 - 0.0054 16.4 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 CRG83448.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Cupin PepX_C PF08530.10 CRG83449.1 - 8.6e-35 120.7 0.4 1.5e-34 120.0 0.4 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 CRG83449.1 - 9.1e-22 77.9 0.1 3.5e-21 76.0 0.2 1.9 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Aldedh PF00171.22 CRG83449.1 - 6.1e-18 64.6 0.0 2.8e-17 62.4 0.0 1.8 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_trans PF04082.18 CRG83450.1 - 3.8e-11 42.5 1.4 6.4e-11 41.8 1.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83450.1 - 0.00017 21.7 12.4 0.00029 20.9 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran PF00005.27 CRG83451.1 - 2.1e-44 151.3 0.0 3.1e-27 95.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG83451.1 - 1.4e-12 47.9 31.6 2e-11 44.0 13.5 3.5 2 1 0 2 2 2 1 ABC transporter transmembrane region LigB PF02900.18 CRG83451.1 - 1.2e-10 41.0 0.0 2e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase SMC_N PF02463.19 CRG83451.1 - 4.2e-09 36.2 0.3 0.31 10.5 0.0 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG83451.1 - 1.4e-08 35.5 1.3 0.001 19.6 0.2 2.3 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CRG83451.1 - 1.9e-08 34.5 0.1 0.074 12.9 0.0 4.1 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG83451.1 - 1.2e-07 31.3 1.7 0.022 14.5 0.0 3.5 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CRG83451.1 - 6.8e-05 23.2 0.0 0.26 11.6 0.0 2.9 2 1 0 2 2 2 2 AAA domain AAA_15 PF13175.6 CRG83451.1 - 8.6e-05 22.4 0.0 0.064 12.9 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 CRG83451.1 - 0.00024 21.3 0.0 0.3 11.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CRG83451.1 - 0.00026 21.1 0.0 0.016 15.2 0.0 2.4 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 CRG83451.1 - 0.00033 21.1 0.0 1.2 9.5 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 CRG83451.1 - 0.0013 18.8 0.0 0.86 9.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA PF00004.29 CRG83451.1 - 0.0017 18.8 0.0 0.1 13.0 0.0 3.3 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 CRG83451.1 - 0.0022 17.9 0.0 0.28 11.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 CRG83451.1 - 0.0031 16.6 0.1 0.68 8.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein cobW PF02492.19 CRG83451.1 - 0.0055 16.3 0.1 3.1 7.4 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_7 PF12775.7 CRG83451.1 - 0.0064 16.0 0.0 0.17 11.4 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 CRG83451.1 - 0.0075 16.8 0.0 1.1 9.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain MobB PF03205.14 CRG83451.1 - 0.012 15.5 0.1 0.94 9.4 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_24 PF13479.6 CRG83451.1 - 0.014 15.1 0.1 0.4 10.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CRG83451.1 - 0.017 15.1 0.1 1.2 9.1 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_1 PF03029.17 CRG83451.1 - 0.018 14.8 0.0 4.3 7.1 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 CRG83451.1 - 0.025 14.3 0.2 0.41 10.4 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein ABC_ATPase PF09818.9 CRG83451.1 - 0.026 13.3 1.8 0.057 12.2 0.1 2.2 3 0 0 3 3 3 0 Predicted ATPase of the ABC class ATPase_2 PF01637.18 CRG83451.1 - 0.027 14.4 0.1 9.5 6.1 0.0 2.5 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea Roc PF08477.13 CRG83451.1 - 0.037 14.3 0.0 5.2 7.3 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_19 PF13245.6 CRG83451.1 - 0.061 13.7 1.1 3.1 8.1 0.0 2.9 3 0 0 3 3 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CRG83451.1 - 0.063 12.6 0.2 3.8 6.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.14 CRG83451.1 - 0.083 12.9 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DEAD PF00270.29 CRG83451.1 - 0.12 12.1 0.3 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA_11 PF13086.6 CRG83451.1 - 0.17 11.6 1.0 1.8 8.3 0.1 2.4 3 0 0 3 3 2 0 AAA domain Adeno_IVa2 PF02456.15 CRG83451.1 - 0.18 10.6 0.1 0.61 8.8 0.0 1.8 2 0 0 2 2 2 0 Adenovirus IVa2 protein NTPase_1 PF03266.15 CRG83451.1 - 0.18 11.7 2.1 8.3 6.3 0.0 3.2 3 0 0 3 3 3 0 NTPase FTHFS PF01268.19 CRG83451.1 - 0.2 9.8 1.0 0.44 8.7 0.1 1.8 2 0 0 2 2 2 0 Formate--tetrahydrofolate ligase TrwB_AAD_bind PF10412.9 CRG83451.1 - 0.64 8.9 2.9 5.7 5.7 0.1 2.9 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain DAO PF01266.24 CRG83452.1 - 8e-37 127.6 0.0 1.1e-36 127.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG83452.1 - 2e-06 27.9 0.0 4.5e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG83452.1 - 0.00028 20.2 0.0 0.13 11.4 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG83452.1 - 0.00062 19.0 0.0 0.29 10.2 0.0 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Trp_halogenase PF04820.14 CRG83452.1 - 0.0033 16.3 0.0 0.22 10.3 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 CRG83452.1 - 0.011 15.0 0.1 0.078 12.2 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG83452.1 - 0.017 14.4 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 CRG83452.1 - 0.018 15.1 0.2 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 CRG83452.1 - 0.027 15.0 0.0 0.62 10.7 0.0 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG83452.1 - 0.029 13.4 0.1 0.062 12.4 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 CRG83452.1 - 0.052 12.2 0.0 4 6.0 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 CRG83452.1 - 0.2 10.9 0.0 0.47 9.6 0.0 1.5 2 0 0 2 2 2 0 Thi4 family AA_permease PF00324.21 CRG83453.1 - 2e-103 346.6 34.0 2.4e-103 346.3 34.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG83453.1 - 1.3e-21 77.0 37.8 1.5e-21 76.7 37.8 1.1 1 0 0 1 1 1 1 Amino acid permease Ring_hydroxyl_A PF00848.19 CRG83454.1 - 8.4e-25 88.0 3.5 5.9e-22 78.7 3.5 2.5 1 1 0 1 1 1 1 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 CRG83454.1 - 2.9e-16 59.2 0.0 5.6e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Fungal_trans PF04082.18 CRG83454.1 - 1.1e-08 34.4 0.7 1.1e-08 34.4 0.7 2.0 3 0 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83454.1 - 2.7e-05 24.2 6.8 6.7e-05 22.9 6.8 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GCV_T PF01571.21 CRG83455.1 - 1.3e-75 254.1 0.0 2.1e-75 253.4 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DAO PF01266.24 CRG83455.1 - 2.5e-45 155.6 0.5 3.6e-45 155.1 0.5 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAO_M PF16350.5 CRG83455.1 - 2.2e-19 69.5 0.0 4.7e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase central domain GCV_T_C PF08669.11 CRG83455.1 - 3e-19 68.7 0.1 9.1e-19 67.2 0.1 1.9 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Pyr_redox_2 PF07992.14 CRG83455.1 - 1.4e-05 24.5 0.1 0.068 12.4 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG83455.1 - 0.002 17.3 0.1 0.0035 16.5 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain TrkA_N PF02254.18 CRG83455.1 - 0.0038 17.5 0.1 0.015 15.6 0.1 2.0 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_9 PF13454.6 CRG83455.1 - 0.0069 16.4 0.2 0.91 9.5 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 CRG83455.1 - 0.0076 16.8 3.5 0.057 14.0 0.1 2.9 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CRG83455.1 - 0.011 15.8 0.1 0.019 15.0 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CRG83455.1 - 0.012 14.9 0.1 0.023 14.1 0.1 1.4 1 0 0 1 1 1 0 ThiF family SoxG PF04268.12 CRG83455.1 - 0.027 14.6 0.0 0.088 13.0 0.0 1.9 1 0 0 1 1 1 0 Sarcosine oxidase, gamma subunit family FAD_binding_3 PF01494.19 CRG83455.1 - 0.037 13.3 0.5 2.1 7.5 0.4 2.2 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 CRG83455.1 - 0.054 12.4 0.2 0.91 8.3 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_8 PF13450.6 CRG83455.1 - 0.15 12.3 0.0 0.64 10.3 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG83455.1 - 0.18 10.8 0.2 1.6 7.7 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein DEAD PF00270.29 CRG83456.1 - 4.1e-40 137.4 0.7 6.6e-40 136.7 0.7 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG83456.1 - 5.9e-33 113.5 0.4 1.1e-30 106.3 0.0 2.4 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 CRG83456.1 - 1e-05 25.6 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 CRG83456.1 - 0.04 13.4 0.6 0.16 11.5 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CRG83456.1 - 0.11 12.8 0.1 1 9.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Acyltransferase PF01553.21 CRG83458.1 - 3.6e-12 46.1 0.0 1.1e-11 44.5 0.0 1.8 1 1 0 1 1 1 1 Acyltransferase L31 PF09784.9 CRG83459.1 - 2e-44 150.2 1.2 2.2e-44 150.0 1.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Cas_Csy3 PF09615.10 CRG83459.1 - 0.099 12.0 0.2 0.11 11.9 0.2 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy3) DUF3235 PF11574.8 CRG83459.1 - 0.11 13.3 0.0 0.16 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) HemY_N PF07219.13 CRG83460.1 - 0.023 14.9 0.9 0.094 12.9 0.3 2.0 2 0 0 2 2 2 0 HemY protein N-terminus Methyltransf_33 PF10017.9 CRG83460.1 - 0.2 10.8 0.5 0.28 10.3 0.5 1.1 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent EBP PF05241.12 CRG83463.1 - 9.4e-65 217.4 6.7 1.1e-64 217.2 6.7 1.0 1 0 0 1 1 1 1 Emopamil binding protein Annexin PF00191.20 CRG83464.1 - 2.2e-61 203.8 4.1 3.4e-16 59.1 0.0 4.2 4 0 0 4 4 4 4 Annexin DUF5638 PF18688.1 CRG83464.1 - 0.0068 16.7 0.6 0.72 10.2 0.0 2.8 3 0 0 3 3 3 1 Family of unknown function (DUF5638) DUF1645 PF07816.11 CRG83464.1 - 0.16 12.5 0.0 0.26 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Acetyltransf_11 PF13720.6 CRG83464.1 - 0.26 11.8 0.9 59 4.2 0.1 3.3 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 SH3_9 PF14604.6 CRG83465.1 - 3e-07 30.2 0.3 2.7e-06 27.1 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain ZZ PF00569.17 CRG83465.1 - 1.7e-05 24.5 5.3 1.7e-05 24.5 5.3 2.4 2 0 0 2 2 2 1 Zinc finger, ZZ type SH3_2 PF07653.17 CRG83465.1 - 3.5e-05 23.4 0.1 0.00017 21.2 0.0 2.1 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 CRG83465.1 - 9.5e-05 21.9 0.1 0.00022 20.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain DUF4428 PF14471.6 CRG83465.1 - 0.88 9.5 5.2 9.6 6.2 2.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) FYVE PF01363.21 CRG83465.1 - 8.9 6.5 11.3 0.15 12.2 3.6 2.0 2 0 0 2 2 2 0 FYVE zinc finger PEP_mutase PF13714.6 CRG83466.1 - 7.4e-45 153.3 0.1 8.6e-45 153.0 0.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CRG83466.1 - 1.6e-21 76.4 0.1 2e-21 76.1 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Pantoate_transf PF02548.15 CRG83466.1 - 0.05 13.0 0.0 0.1 12.0 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase Ig_GlcNase PF18368.1 CRG83468.1 - 1e-33 115.6 1.1 1e-33 115.6 1.1 2.1 2 0 0 2 2 2 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 CRG83468.1 - 2e-10 41.3 5.3 2.5e-10 41.0 0.1 2.9 3 0 0 3 3 3 1 Glycosyl hydrolases family 2 Mannosidase_ig PF17786.1 CRG83468.1 - 1.2e-07 32.2 4.1 1.7e-06 28.6 0.2 3.2 3 0 0 3 3 3 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2_N PF02837.18 CRG83468.1 - 7.5e-06 25.9 0.1 1.8e-05 24.7 0.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Ig_mannosidase PF17753.1 CRG83468.1 - 0.0014 18.3 2.7 0.0048 16.6 0.1 3.0 3 0 0 3 3 3 1 Ig-fold domain Feld-I_B PF09252.10 CRG83468.1 - 0.16 11.9 0.0 0.39 10.7 0.0 1.5 1 0 0 1 1 1 0 Allergen Fel d I-B chain Dabb PF07876.12 CRG83469.1 - 1.1e-21 77.2 0.0 1.2e-21 77.1 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain ECD PF18432.1 CRG83469.1 - 0.015 15.2 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Extracellular Cadherin domain FAD_binding_3 PF01494.19 CRG83470.1 - 6e-12 45.5 0.0 1.1e-11 44.6 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG83470.1 - 2.7e-09 37.1 0.2 1.6e-08 34.6 0.1 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG83470.1 - 0.0003 20.1 0.0 0.0011 18.3 0.0 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CRG83470.1 - 0.00049 20.3 0.0 0.0013 18.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG83470.1 - 0.0041 16.4 0.0 0.12 11.5 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG83470.1 - 0.016 14.0 0.0 1.3 7.8 0.0 2.3 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_9 PF13454.6 CRG83470.1 - 0.029 14.3 0.1 0.063 13.3 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CRG83470.1 - 0.033 13.3 0.1 0.054 12.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain Mannosyl_trans PF05007.13 CRG83471.1 - 1.1e-75 254.8 16.4 1.1e-75 254.8 16.4 1.5 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 CRG83471.1 - 2.9e-11 43.0 7.2 2.9e-11 43.0 7.2 2.3 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 CRG83471.1 - 0.001 18.9 17.7 0.001 18.9 17.7 2.6 2 1 0 2 2 2 1 Glycosyltransferase family 87 FimH_man-bind PF09160.10 CRG83471.1 - 0.062 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 FimH, mannose binding NIBRIN_BRCT_II PF16508.5 CRG83473.1 - 1.1e-35 122.6 0.0 4e-35 120.7 0.0 2.0 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 CRG83473.1 - 2.2e-06 27.9 0.3 5.1e-06 26.7 0.3 1.7 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CRG83473.1 - 0.0035 17.6 0.2 0.042 14.2 0.2 2.5 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 PF16770.5 CRG83473.1 - 0.01 15.7 0.0 0.033 14.1 0.0 1.8 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain IMS PF00817.20 CRG83474.1 - 2.3e-43 147.8 0.8 4.4e-43 146.9 0.8 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CRG83474.1 - 3.1e-16 60.1 0.1 1e-15 58.5 0.1 1.8 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 CRG83474.1 - 5.4e-07 29.6 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif Vps36-NZF-N PF16988.5 CRG83474.1 - 0.091 12.2 0.2 0.25 10.8 0.2 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Zn-C2H2_12 PF18112.1 CRG83474.1 - 0.13 12.7 0.3 0.4 11.2 0.3 1.8 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain DnaJ-X PF14308.6 CRG83476.1 - 1.1e-69 234.1 6.0 1.1e-69 234.1 6.0 3.2 3 1 0 3 3 3 1 X-domain of DnaJ-containing DnaJ PF00226.31 CRG83476.1 - 3.1e-25 88.1 0.2 9.6e-25 86.5 0.2 1.9 1 0 0 1 1 1 1 DnaJ domain SQS_PSY PF00494.19 CRG83477.1 - 1.9e-37 129.2 0.0 2.6e-37 128.8 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Synaptobrevin PF00957.21 CRG83477.1 - 0.0028 17.4 1.9 0.51 10.2 0.6 2.6 1 1 1 2 2 2 2 Synaptobrevin CdiA_C PF18451.1 CRG83477.1 - 0.0037 17.4 0.0 0.02 15.1 0.0 2.2 2 0 0 2 2 2 1 Contact-dependent growth inhibition CdiA C-terminal domain PepSY_2 PF13670.6 CRG83477.1 - 0.21 11.6 0.7 1.7 8.7 0.1 2.4 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain COesterase PF00135.28 CRG83478.1 - 6.7e-28 97.8 0.0 4.4e-22 78.6 0.0 2.1 1 1 1 2 2 2 2 Carboxylesterase family Hemerythrin PF01814.23 CRG83478.1 - 5.3e-10 40.0 0.3 9.4e-10 39.2 0.3 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain PPR PF01535.20 CRG83478.1 - 0.084 13.2 0.0 36 4.9 0.0 3.1 2 0 0 2 2 2 0 PPR repeat DUF5548 PF17702.1 CRG83478.1 - 0.12 12.1 0.1 7.9 6.2 0.0 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5548) BAAT_C PF08840.11 CRG83479.1 - 0.016 15.1 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 CRG83479.1 - 0.13 11.8 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family Peptidase_A4 PF01828.17 CRG83480.1 - 7.4e-79 264.1 15.2 8.8e-79 263.8 15.2 1.1 1 0 0 1 1 1 1 Peptidase A4 family DUF11 PF01345.18 CRG83480.1 - 0.015 15.5 5.6 2.1 8.7 0.3 3.0 2 1 0 2 2 2 0 Domain of unknown function DUF11 Poly_export PF02563.16 CRG83480.1 - 0.059 13.6 0.2 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 Polysaccharide biosynthesis/export protein Translin PF01997.16 CRG83481.1 - 7.5e-72 241.6 0.3 9.5e-72 241.3 0.3 1.1 1 0 0 1 1 1 1 Translin family DUF3450 PF11932.8 CRG83481.1 - 0.015 14.6 0.1 0.1 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF3689 PF12463.8 CRG83481.1 - 0.15 11.4 0.1 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3689) RPEL PF02755.15 CRG83482.1 - 1e-23 82.2 21.7 8.8e-09 34.8 4.0 3.4 3 0 0 3 3 3 3 RPEL repeat CP12 PF02672.15 CRG83482.1 - 0.15 12.9 1.8 4 8.3 0.2 2.7 3 0 0 3 3 3 0 CP12 domain PIN_4 PF13638.6 CRG83483.1 - 0.026 14.8 0.0 1.5 9.1 0.0 2.3 2 0 0 2 2 2 0 PIN domain LLC1 PF14945.6 CRG83483.1 - 0.27 11.8 2.8 2.5 8.7 0.1 2.9 2 1 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Rhodanese PF00581.20 CRG83484.1 - 8.2e-18 64.9 0.0 5.7e-08 33.2 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain zf-ANAPC11 PF12861.7 CRG83485.1 - 6.3e-25 87.1 2.8 1.1e-24 86.3 2.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CRG83485.1 - 2.5e-05 24.5 0.5 4.6e-05 23.6 0.5 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain DMPK_coil PF08826.10 CRG83485.1 - 0.32 11.2 1.4 0.54 10.4 1.4 1.3 1 0 0 1 1 1 0 DMPK coiled coil domain like DUF3123 PF11321.8 CRG83485.1 - 1.9 9.2 4.5 7.4 7.3 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Kinesin PF00225.23 CRG83486.1 - 7.7e-109 363.6 4.2 7.7e-109 363.6 4.2 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CRG83486.1 - 6.2e-25 87.9 1.7 1.4e-24 86.7 0.1 2.5 2 0 0 2 2 2 1 Microtubule binding Microtub_bind PF13931.6 CRG83486.1 - 5e-06 26.9 2.8 5e-06 26.9 2.8 4.7 3 1 1 4 4 4 1 Kinesin-associated microtubule-binding Baculo_PEP_C PF04513.12 CRG83486.1 - 0.0045 17.0 0.1 0.0045 17.0 0.1 5.4 3 2 0 5 5 5 1 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 CRG83486.1 - 0.085 11.7 41.3 0.065 12.1 9.8 4.0 2 1 1 3 3 3 0 Spc7 kinetochore protein B2 PF11473.8 CRG83486.1 - 0.24 11.2 1.0 1.6 8.6 0.0 2.9 3 0 0 3 3 3 0 RNA binding protein B2 Apolipoprotein PF01442.18 CRG83486.1 - 0.31 10.9 44.4 0.31 10.9 21.3 4.6 2 1 2 4 4 4 0 Apolipoprotein A1/A4/E domain UPF0183 PF03676.14 CRG83487.1 - 3.6e-54 184.6 0.0 4.8e-36 124.9 0.0 2.9 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0183) tRNA-synt_1 PF00133.22 CRG83488.1 - 6.5e-157 523.4 0.0 8.5e-157 523.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CRG83488.1 - 2.1e-21 76.5 0.1 4.5e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CRG83488.1 - 1.2e-17 63.8 0.0 1.1e-11 44.2 0.0 3.9 3 1 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CRG83488.1 - 0.0096 15.3 0.0 1 8.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain zf-FPG_IleRS PF06827.14 CRG83488.1 - 0.043 13.7 4.1 0.095 12.6 4.1 1.6 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS tRNA-synt_1_2 PF13603.6 CRG83488.1 - 0.072 12.6 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 Bac_rhodopsin PF01036.18 CRG83489.1 - 6.9e-39 133.7 16.3 9.2e-39 133.3 16.3 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein DUF5596 PF18082.1 CRG83489.1 - 0.049 13.5 0.1 0.88 9.4 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5596) DUF2768 PF10966.8 CRG83489.1 - 0.09 13.2 8.7 1.2 9.6 2.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2768) S10_plectin PF03501.15 CRG83489.1 - 0.14 12.2 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Plectin/S10 domain YibE_F PF07907.11 CRG83489.1 - 0.21 11.1 12.7 0.14 11.7 7.3 2.1 2 0 0 2 2 2 0 YibE/F-like protein Phage_holin_3_6 PF07332.11 CRG83489.1 - 0.24 11.4 14.8 0.053 13.6 2.6 2.8 2 1 1 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III SUR7 PF06687.12 CRG83489.1 - 4.9 6.7 9.8 3.6 7.2 0.4 2.5 2 1 0 2 2 2 0 SUR7/PalI family FTH PF01827.27 CRG83490.1 - 0.15 11.9 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 FTH domain Ribosomal_S5 PF00333.20 CRG83491.1 - 1.1e-26 92.5 1.9 2e-26 91.7 0.5 2.1 3 0 0 3 3 3 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 CRG83491.1 - 8.8e-23 79.6 0.1 1.4e-22 78.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 CRG83491.1 - 3.6 8.2 9.8 8.2 7.1 9.8 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Mpv17_PMP22 PF04117.12 CRG83492.1 - 8.7e-22 77.1 1.4 9.2e-22 77.0 0.3 1.6 2 0 0 2 2 2 1 Mpv17 / PMP22 family IF4E PF01652.18 CRG83493.1 - 1.8e-53 180.6 0.3 2.2e-53 180.3 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Fungal_trans_2 PF11951.8 CRG83494.1 - 1.9e-09 36.8 0.7 2.4e-08 33.2 0.7 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG83495.1 - 1.9e-39 135.6 49.0 3.6e-39 134.7 49.0 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG83495.1 - 6.3e-16 57.9 19.4 7.6e-16 57.6 19.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) APH PF01636.23 CRG83496.1 - 0.00039 20.4 0.0 0.00051 20.0 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family DEAD PF00270.29 CRG83497.1 - 1.8e-49 167.9 0.0 2.6e-49 167.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG83497.1 - 1.4e-29 102.6 0.3 1.1e-28 99.8 0.0 2.5 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG83497.1 - 2e-05 24.6 0.0 4.3e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG83497.1 - 0.00073 18.8 0.1 0.0013 18.0 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 CRG83497.1 - 0.023 14.4 0.0 0.075 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain SNF2_N PF00176.23 CRG83497.1 - 0.063 12.0 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain Flavi_DEAD PF07652.14 CRG83497.1 - 0.07 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain Aldo_ket_red PF00248.21 CRG83498.1 - 2.1e-44 151.9 0.0 2.5e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PTR2 PF00854.21 CRG83499.1 - 7.7e-91 304.9 6.3 1.3e-90 304.1 6.3 1.3 1 1 0 1 1 1 1 POT family Glyco_hydro_3 PF00933.21 CRG83500.1 - 8e-48 163.4 0.0 1.1e-47 162.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CRG83500.1 - 4.5e-41 141.1 0.0 6.6e-41 140.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CRG83500.1 - 5.9e-12 45.5 0.5 1.2e-11 44.5 0.5 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CRG83500.1 - 1.3e-08 34.7 0.2 1.4e-07 31.4 0.0 2.5 2 0 0 2 2 2 1 PA14 domain CARDB PF07705.11 CRG83500.1 - 0.0083 16.4 0.9 0.032 14.5 0.5 2.1 1 1 0 1 1 1 1 CARDB Fungal_trans PF04082.18 CRG83501.1 - 2.7e-07 29.9 0.0 8.2e-07 28.3 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain MIF4G_like_2 PF09090.11 CRG83501.1 - 0.062 12.8 0.1 0.16 11.4 0.1 1.7 1 0 0 1 1 1 0 MIF4G like Zn_clus PF00172.18 CRG83501.1 - 0.079 13.1 0.7 0.18 12.0 0.7 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG83501.1 - 0.088 11.6 1.2 0.54 9.0 0.3 2.2 2 0 0 2 2 2 0 Fungal specific transcription factor domain UDPGP PF01704.18 CRG83502.1 - 6.1e-191 634.5 0.0 7.1e-191 634.3 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 CRG83502.1 - 0.6 8.9 3.2 1.8 7.3 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4301) C2 PF00168.30 CRG83503.1 - 2.1e-74 246.3 0.0 2.1e-19 69.7 0.0 5.8 6 0 0 6 6 6 5 C2 domain SMP_LBD PF17047.5 CRG83503.1 - 0.002 17.7 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain ADH_N PF08240.12 CRG83504.1 - 7.9e-19 67.5 1.8 1.4e-18 66.7 1.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG83504.1 - 1e-12 48.1 0.0 1.9e-12 47.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG83504.1 - 2.3e-05 23.8 0.1 4.3e-05 22.9 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TOM6p PF15184.6 CRG83504.1 - 0.0031 17.3 0.0 0.0067 16.2 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial import receptor subunit TOM6 homolog AlaDh_PNT_C PF01262.21 CRG83504.1 - 0.0033 16.8 0.0 0.005 16.1 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CRG83504.1 - 0.13 12.2 0.1 0.29 11.0 0.1 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 CRG83504.1 - 0.17 11.2 0.4 0.34 10.2 0.4 1.4 1 0 0 1 1 1 0 ThiF family TnpV PF14198.6 CRG83505.1 - 0.052 13.5 0.0 0.059 13.4 0.0 1.1 1 0 0 1 1 1 0 Transposon-encoded protein TnpV Peptidase_S28 PF05577.12 CRG83506.1 - 6.4e-47 160.3 0.1 1.1e-46 159.6 0.1 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase S28 MFS_1 PF07690.16 CRG83507.1 - 1.2e-06 27.7 26.7 1.4e-06 27.5 23.1 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily YscO-like PF16789.5 CRG83507.1 - 0.048 13.7 0.6 3.1 7.8 0.1 2.1 2 0 0 2 2 2 0 YscO-like protein Abhydrolase_9_N PF15420.6 CRG83507.1 - 0.96 9.4 5.0 3.4 7.6 0.0 3.0 3 0 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus Amidase PF01425.21 CRG83509.1 - 2.7e-87 293.6 0.0 6.7e-87 292.3 0.0 1.6 1 1 0 1 1 1 1 Amidase zf-CCCH PF00642.24 CRG83510.1 - 3.2e-08 33.3 20.0 3e-07 30.2 2.5 3.1 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 CRG83510.1 - 0.0033 17.2 0.0 0.0052 16.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CRG83510.1 - 0.0058 16.7 3.3 0.0058 16.7 3.3 3.3 3 0 0 3 3 3 1 Zinc finger domain Torus PF16131.5 CRG83510.1 - 0.012 16.3 3.5 0.48 11.1 0.2 2.5 2 0 0 2 2 2 0 Torus domain zf-CCCH_3 PF15663.5 CRG83510.1 - 4.6 7.5 9.3 0.31 11.3 1.2 2.5 1 1 0 2 2 2 0 Zinc-finger containing family PBP_N PF17093.5 CRG83511.1 - 0.0014 18.9 0.3 0.0019 18.5 0.3 1.2 1 0 0 1 1 1 1 Penicillin-binding protein N-terminus DUF4366 PF14283.6 CRG83511.1 - 0.02 15.0 0.0 0.023 14.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) DUF3040 PF11239.8 CRG83511.1 - 0.04 14.2 0.1 0.11 12.8 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3040) Astro_capsid_N PF03115.14 CRG83511.1 - 0.078 11.6 0.2 0.091 11.4 0.2 1.0 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF2207 PF09972.9 CRG83511.1 - 0.099 11.4 0.1 0.1 11.3 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Vezatin PF12632.7 CRG83511.1 - 0.73 9.1 2.4 1.3 8.4 2.1 1.4 2 0 0 2 2 2 0 Mysoin-binding motif of peroxisomes APH PF01636.23 CRG83512.1 - 6.5e-12 45.9 0.3 3.7e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG83512.1 - 9.8e-06 25.3 0.0 3.2e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Zn_clus PF00172.18 CRG83512.1 - 9.6e-05 22.4 12.4 0.00017 21.7 12.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EcKinase PF02958.20 CRG83512.1 - 0.00051 19.4 0.0 0.001 18.5 0.0 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CRG83512.1 - 0.017 14.0 0.0 0.03 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Fungal_trans PF04082.18 CRG83512.1 - 0.028 13.5 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Fructosamin_kin PF03881.14 CRG83512.1 - 0.032 13.4 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Fructosamine kinase PRELI PF04707.14 CRG83512.1 - 0.05 13.4 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 PRELI-like family UQ_con PF00179.26 CRG83514.1 - 8.6e-44 148.6 0.0 9.8e-44 148.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TFIIIC_delta PF12657.7 CRG83515.1 - 8.1e-45 153.0 2.5 2.1e-44 151.6 2.5 1.8 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 CRG83515.1 - 3.8e-23 81.4 0.5 1.2e-22 79.8 0.5 1.9 1 1 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex ANAPC4_WD40 PF12894.7 CRG83515.1 - 0.052 13.8 0.9 14 6.1 0.0 4.1 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Cation_efflux PF01545.21 CRG83516.1 - 1.4e-47 162.1 15.2 1.4e-47 162.1 15.2 3.9 4 0 0 4 4 4 2 Cation efflux family Zip PF02535.22 CRG83516.1 - 0.01 15.1 0.5 0.01 15.1 0.5 4.5 2 1 1 3 3 3 0 ZIP Zinc transporter Glyco_trans_1_4 PF13692.6 CRG83517.1 - 2.8e-07 31.0 0.0 5e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CRG83517.1 - 5.4e-07 29.8 0.1 1.1e-06 28.8 0.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CRG83517.1 - 9e-07 29.5 0.1 1.7e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CRG83517.1 - 0.044 14.2 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Thiolase_N PF00108.23 CRG83518.1 - 6.3e-93 310.9 1.2 1e-92 310.2 1.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG83518.1 - 2.8e-38 130.3 0.8 2.8e-38 130.3 0.8 1.9 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CRG83518.1 - 1.9e-05 24.4 0.7 5e-05 23.0 0.4 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Inhibitor_I66 PF16850.5 CRG83518.1 - 0.12 12.2 0.1 17 5.2 0.2 2.3 2 0 0 2 2 2 0 Peptidase inhibitor I66 Kinesin PF00225.23 CRG83519.1 - 5.3e-110 367.5 0.7 1.3e-109 366.2 0.7 1.6 1 0 0 1 1 1 1 Kinesin motor domain UQ_con PF00179.26 CRG83519.1 - 4.2e-47 159.3 0.0 9.6e-47 158.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Microtub_bd PF16796.5 CRG83519.1 - 1.2e-25 90.2 0.1 3.6e-25 88.7 0.1 1.8 1 0 0 1 1 1 1 Microtubule binding DUF2048 PF09752.9 CRG83519.1 - 0.032 13.3 1.5 0.067 12.3 1.5 1.4 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Hydant_A_N PF05378.13 CRG83519.1 - 0.054 13.2 0.7 0.19 11.4 0.4 2.2 1 1 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region HAP1_N PF04849.13 CRG83519.1 - 0.14 11.4 52.1 0.062 12.5 14.7 4.1 3 2 0 3 3 3 0 HAP1 N-terminal conserved region Peptidase_C1_2 PF03051.15 CRG83522.1 - 6.2e-157 522.9 0.0 7.2e-157 522.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 CRG83522.1 - 2e-07 31.3 0.2 0.013 15.6 0.2 2.4 2 0 0 2 2 2 2 Papain family cysteine protease DUF4296 PF14129.6 CRG83522.1 - 0.006 17.2 0.0 0.017 15.7 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4296) Soc PF16855.5 CRG83523.1 - 0.014 15.9 0.4 0.025 15.1 0.4 1.4 1 0 0 1 1 1 0 Small outer capsid protein FAD_binding_3 PF01494.19 CRG83524.1 - 8e-21 74.7 0.6 2.9e-09 36.7 0.0 2.3 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG83524.1 - 0.00024 21.3 0.0 0.00055 20.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG83524.1 - 0.00038 19.6 0.2 0.021 13.9 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG83524.1 - 0.0014 17.9 0.0 0.0036 16.6 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG83524.1 - 0.011 15.3 0.2 0.81 9.2 0.1 2.1 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG83524.1 - 0.02 14.2 0.2 0.031 13.5 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG83524.1 - 0.028 13.7 0.0 0.043 13.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CRG83524.1 - 0.04 14.5 0.0 0.33 11.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CRG83524.1 - 0.067 12.2 0.0 0.28 10.2 0.0 1.8 2 0 0 2 2 2 0 Squalene epoxidase NAD_Gly3P_dh_N PF01210.23 CRG83524.1 - 0.11 12.4 0.1 0.28 11.1 0.0 1.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_9 PF13454.6 CRG83524.1 - 0.14 12.1 0.1 0.31 11.0 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Caps_synth PF05704.12 CRG83525.1 - 1.5e-11 44.2 0.0 2.5e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 CRG83525.1 - 2.2e-05 25.0 0.1 5.3e-05 23.8 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF3806 PF12713.7 CRG83525.1 - 0.033 13.9 0.2 0.088 12.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3806) Methyltransf_2 PF00891.18 CRG83526.1 - 1.2e-08 34.5 0.2 2.8e-08 33.3 0.2 1.6 1 1 0 1 1 1 1 O-methyltransferase domain Sugar_tr PF00083.24 CRG83527.1 - 1.5e-93 314.2 21.4 1.7e-93 314.0 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83527.1 - 3.1e-20 72.4 44.0 2e-18 66.4 21.5 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1304 PF06993.12 CRG83527.1 - 0.26 11.3 15.6 0.59 10.2 0.6 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF1304) Glyco_hydro_31 PF01055.26 CRG83528.1 - 2.4e-154 514.8 0.1 4.4e-154 513.9 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG83528.1 - 9.7e-41 138.6 0.0 2.4e-40 137.4 0.0 1.7 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase CBM_20 PF00686.19 CRG83528.1 - 1.5e-19 69.7 0.4 3.5e-19 68.5 0.4 1.7 1 0 0 1 1 1 1 Starch binding domain Gal_mutarotas_2 PF13802.6 CRG83528.1 - 1.8e-10 41.0 1.2 4.3e-10 39.8 0.3 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like DUF3327 PF11806.8 CRG83528.1 - 0.025 15.3 0.0 0.056 14.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3327) DUF5110 PF17137.4 CRG83528.1 - 0.073 13.3 0.3 1.8 8.9 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) Lactamase_B PF00753.27 CRG83529.1 - 2e-16 60.6 3.9 2.1e-14 54.0 3.9 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG83529.1 - 3.8e-05 23.3 0.2 7.9e-05 22.3 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CRG83529.1 - 0.0048 16.8 0.1 0.01 15.7 0.1 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Fasciclin PF02469.22 CRG83530.1 - 2.9e-33 114.8 0.0 1.6e-19 70.4 0.0 2.6 2 0 0 2 2 2 2 Fasciclin domain Cu-oxidase_2 PF07731.14 CRG83531.1 - 2e-23 82.7 6.3 9.7e-23 80.4 1.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG83531.1 - 5.9e-23 81.1 1.9 8.2e-23 80.7 0.6 2.0 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG83531.1 - 8.7e-15 55.2 0.0 1.2e-13 51.5 0.0 2.6 3 1 0 3 3 3 1 Multicopper oxidase ketoacyl-synt PF00109.26 CRG83532.1 - 2.3e-70 237.1 0.0 3.5e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 CRG83532.1 - 2.1e-40 139.0 0.0 5.4e-40 137.6 0.0 1.7 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 CRG83532.1 - 7.2e-38 130.9 0.0 3.6e-36 125.3 0.0 2.2 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG83532.1 - 1.7e-32 111.9 0.1 3.4e-32 110.9 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG83532.1 - 1.5e-10 41.5 0.0 3.9e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 CRG83532.1 - 5.6e-10 39.4 0.7 1.5e-09 38.1 0.7 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CRG83532.1 - 0.0012 18.2 0.1 0.0023 17.4 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain PP2C PF00481.21 CRG83533.1 - 1.3e-33 116.7 0.0 2.1e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CRG83533.1 - 0.00014 21.6 0.0 0.00024 20.8 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CRG83533.1 - 0.014 15.3 0.1 0.96 9.3 0.0 2.8 3 1 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) 2OG-FeII_Oxy PF03171.20 CRG83534.1 - 6.5e-20 71.5 0.0 1.9e-19 70.0 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG83534.1 - 3.9e-15 56.6 0.0 6.7e-15 55.9 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal MFS_1 PF07690.16 CRG83535.1 - 1.5e-23 83.3 75.7 5e-17 61.8 46.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CRG83535.1 - 6e-06 25.8 19.2 6.1e-06 25.8 17.0 1.8 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB VIT1 PF01988.19 CRG83535.1 - 0.043 13.7 0.5 0.043 13.7 0.5 3.1 3 0 0 3 3 3 0 VIT family Ost4 PF10215.9 CRG83535.1 - 3.6 7.5 7.2 15 5.5 0.1 4.0 4 0 0 4 4 4 0 Oligosaccaryltransferase Tannase PF07519.11 CRG83536.1 - 4.3e-104 349.0 0.4 5e-104 348.8 0.4 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Neil1-DNA_bind PF09292.10 CRG83536.1 - 0.033 14.2 0.0 1.7 8.7 0.0 3.2 3 0 0 3 3 3 0 Endonuclease VIII-like 1, DNA bind YvfG PF09628.10 CRG83536.1 - 0.08 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 YvfG protein Abhydrolase_3 PF07859.13 CRG83537.1 - 1.2e-38 133.1 0.0 1.8e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG83537.1 - 4.3e-06 26.3 0.1 1.1e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family AXE1 PF05448.12 CRG83537.1 - 7.1e-05 21.6 0.0 0.0001 21.1 0.0 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CRG83537.1 - 0.0036 16.9 0.0 0.007 15.9 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CRG83537.1 - 0.008 16.0 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase COesterase PF00135.28 CRG83537.1 - 0.029 13.2 0.1 0.065 12.1 0.0 1.5 2 0 0 2 2 2 0 Carboxylesterase family Abhydrolase_6 PF12697.7 CRG83537.1 - 0.039 14.5 7.7 0.047 14.3 6.9 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.16 CRG83538.1 - 6.6e-34 117.4 28.0 6.6e-34 117.4 28.0 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83538.1 - 9.8e-10 37.9 18.6 1.4e-09 37.4 18.6 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter Phage_holin_5_1 PF06946.11 CRG83538.1 - 0.076 13.4 0.1 0.27 11.6 0.1 1.9 1 0 0 1 1 1 0 Bacteriophage A118-like holin, Hol118 adh_short_C2 PF13561.6 CRG83539.1 - 8.5e-29 100.8 0.0 1.1e-28 100.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83539.1 - 5e-19 68.5 0.0 6.8e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG83539.1 - 8.4e-05 22.6 0.0 0.00012 22.1 0.0 1.2 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 CRG83539.1 - 0.026 15.1 0.0 0.043 14.4 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent MFS_1 PF07690.16 CRG83540.1 - 7.5e-47 160.0 31.8 7.5e-47 160.0 31.8 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG83540.1 - 3.1e-06 26.3 0.0 0.00032 19.7 0.0 3.0 1 1 2 3 3 3 2 MFS_1 like family MFS_4 PF06779.14 CRG83540.1 - 0.00023 20.6 6.5 0.00023 20.6 6.5 3.3 2 1 2 4 4 4 2 Uncharacterised MFS-type transporter YbfB Baculo_11_kDa PF06143.11 CRG83540.1 - 0.057 13.0 0.1 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family DUF2615 PF11027.8 CRG83540.1 - 0.077 13.1 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) OATP PF03137.20 CRG83540.1 - 1.5 7.0 17.3 1.6 6.9 7.5 3.3 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1 PF07690.16 CRG83541.1 - 0.094 11.6 19.3 0.3 10.0 8.3 2.0 1 1 1 2 2 2 0 Major Facilitator Superfamily Kinesin PF00225.23 CRG83542.1 - 4.6e-40 137.6 0.0 8.6e-40 136.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain MFS_1 PF07690.16 CRG83542.1 - 2.8e-30 105.5 30.5 4.1e-30 104.9 30.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Microtub_bd PF16796.5 CRG83542.1 - 2.2e-09 37.4 0.0 4.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding kleA_kleC PF17383.2 CRG83542.1 - 0.12 12.7 0.0 0.38 11.1 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A SAM_PNT PF02198.16 CRG83542.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain adh_short_C2 PF13561.6 CRG83543.1 - 2.7e-53 180.9 0.5 3.2e-53 180.7 0.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83543.1 - 1.3e-44 152.0 0.5 1.8e-44 151.6 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG83543.1 - 2.1e-10 40.8 0.1 3.3e-10 40.2 0.1 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CRG83543.1 - 0.043 13.1 0.4 0.081 12.2 0.4 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Methyltransf_2 PF00891.18 CRG83544.1 - 9.7e-26 90.4 0.0 1.6e-25 89.7 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation PF08100.11 CRG83544.1 - 0.0055 16.7 0.1 0.027 14.5 0.1 2.3 2 0 0 2 2 2 1 Dimerisation domain Sugar_tr PF00083.24 CRG83545.1 - 3.9e-27 95.2 15.5 4.3e-27 95.1 15.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83545.1 - 5.2e-06 25.6 14.3 6.8e-06 25.2 14.3 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3792 PF12670.7 CRG83545.1 - 0.21 11.8 14.6 0.025 14.7 8.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) SVM_signal PF12113.8 CRG83545.1 - 0.53 10.2 0.1 0.53 10.2 0.1 3.3 3 0 0 3 3 3 0 SVM protein signal sequence TPP_enzyme_N PF02776.18 CRG83546.1 - 1.6e-54 184.1 0.1 1.6e-53 180.9 0.0 2.6 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG83546.1 - 6.8e-48 162.3 0.1 2.2e-46 157.5 0.0 2.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG83546.1 - 3.3e-38 130.5 0.2 6.2e-38 129.6 0.2 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Ank_2 PF12796.7 CRG83546.1 - 2.2e-21 76.2 0.2 4.9e-12 46.3 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG83546.1 - 4e-19 68.7 0.9 1.1e-09 38.6 0.1 3.3 2 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83546.1 - 2.6e-17 61.1 2.5 2.1e-05 24.5 0.0 5.1 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 CRG83546.1 - 1.2e-16 60.5 0.8 2.7e-09 37.1 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG83546.1 - 3.4e-13 49.4 7.2 0.00027 21.2 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat PEHE PF15275.6 CRG83546.1 - 0.21 12.2 5.1 0.079 13.6 2.2 1.7 2 0 0 2 2 2 0 PEHE domain adh_short PF00106.25 CRG83547.1 - 3.4e-35 121.3 0.2 4.4e-35 120.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83547.1 - 2e-23 83.2 0.0 2.6e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 CRG83547.1 - 2.7e-07 30.3 0.0 4.2e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 CRG83547.1 - 0.0074 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Epimerase PF01370.21 CRG83547.1 - 0.016 14.7 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 CRG83547.1 - 0.17 11.7 0.8 0.35 10.6 0.3 1.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PAE PF03283.13 CRG83547.1 - 0.21 10.7 0.1 0.25 10.4 0.1 1.3 1 0 0 1 1 1 0 Pectinacetylesterase UBA2_C PF16195.5 CRG83549.1 - 0.017 15.8 2.4 0.05 14.3 2.4 1.8 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus ANAPC1 PF12859.7 CRG83550.1 - 1.2e-28 100.2 1.0 1.2e-28 100.2 1.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 CRG83550.1 - 9.3e-05 22.7 3.4 0.076 13.5 0.0 4.2 4 0 0 4 4 4 2 Proteasome/cyclosome repeat Abhydrolase_3 PF07859.13 CRG83551.1 - 1.1e-47 162.6 0.0 1.4e-47 162.3 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CRG83551.1 - 0.0011 17.9 0.2 0.0021 17.0 0.0 1.4 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 CRG83551.1 - 0.053 13.0 0.0 1.7 8.0 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Fungal_trans_2 PF11951.8 CRG83552.1 - 4.2e-46 157.5 3.9 6.2e-46 156.9 3.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Syntaxin-6_N PF09177.11 CRG83552.1 - 0.05 14.2 0.1 0.12 12.9 0.1 1.6 1 0 0 1 1 1 0 Syntaxin 6, N-terminal MFS_1 PF07690.16 CRG83553.1 - 2.1e-27 96.0 28.3 2.1e-27 96.0 28.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG83553.1 - 0.0013 18.1 1.7 0.0013 18.1 1.7 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB ESSS PF10183.9 CRG83553.1 - 0.0091 16.2 0.1 0.029 14.6 0.1 1.8 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) RPAP1_C PF08620.10 CRG83554.1 - 5.7e-24 84.0 0.6 9.6e-24 83.3 0.0 1.7 2 0 0 2 2 2 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 CRG83554.1 - 5.7e-16 58.0 5.7 1.1e-15 57.1 5.7 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal HUN PF08729.10 CRG83555.1 - 1.3e-07 31.5 0.3 3e-07 30.3 0.3 1.7 1 0 0 1 1 1 1 HPC2 and ubinuclein domain IFRD PF05004.13 CRG83556.1 - 2.3e-87 293.0 7.7 3e-87 292.6 7.7 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) DUF4698 PF15769.5 CRG83556.1 - 0.0099 15.0 0.4 0.024 13.7 0.4 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4698) Glyco_hydro_46 PF01374.18 CRG83556.1 - 0.031 13.9 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 Cellulase PF00150.18 CRG83557.1 - 2.3e-17 63.4 1.0 3e-17 63.0 1.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PHM7_cyt PF14703.6 CRG83557.1 - 0.1 12.9 0.0 0.28 11.4 0.0 1.6 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Transp_cyt_pur PF02133.15 CRG83558.1 - 2.4e-91 306.7 43.5 2.8e-91 306.5 43.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SGL PF08450.12 CRG83559.1 - 1.8e-57 194.7 0.1 2.1e-57 194.5 0.1 1.0 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 CRG83559.1 - 0.00061 19.7 0.0 0.0021 18.0 0.0 2.0 2 0 0 2 2 2 1 NHL repeat Toxin_13 PF07822.11 CRG83559.1 - 0.008 16.3 0.1 0.014 15.5 0.1 1.3 1 0 0 1 1 1 1 Neurotoxin B-IV-like protein DUF839 PF05787.13 CRG83559.1 - 0.023 13.9 0.0 0.043 13.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) Reg_prop PF07494.11 CRG83559.1 - 0.026 14.7 0.6 3 8.4 0.1 3.8 3 0 0 3 3 3 0 Two component regulator propeller Oxysterol_BP PF01237.18 CRG83560.1 - 4e-115 384.6 0.0 7.8e-115 383.7 0.0 1.5 1 0 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 CRG83560.1 - 6.2e-38 129.0 0.2 6.2e-38 129.0 0.2 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 CRG83560.1 - 2.5e-07 31.2 0.0 6.2e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 CRG83560.1 - 0.046 14.1 1.1 0.49 10.8 1.1 2.3 1 1 0 1 1 1 0 Pleckstrin homology domain CAP160 PF07918.11 CRG83560.1 - 0.11 12.3 1.2 5 7.0 0.1 2.6 2 0 0 2 2 2 0 CAP160 repeat DUF346 PF03984.13 CRG83562.1 - 4e-11 42.5 49.8 0.0001 22.0 0.4 7.7 8 0 0 8 8 8 5 Repeat of unknown function (DUF346) DUF2510 PF10708.9 CRG83562.1 - 0.0045 16.7 0.3 0.0045 16.7 0.3 5.7 6 0 0 6 6 6 1 Protein of unknown function (DUF2510) HILPDA PF15220.6 CRG83562.1 - 0.083 13.0 0.1 0.083 13.0 0.1 5.6 7 0 0 7 7 7 0 Hypoxia-inducible lipid droplet-associated SH2_2 PF14633.6 CRG83563.1 - 7.5e-87 290.3 0.0 2.7e-86 288.5 0.0 2.0 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 CRG83563.1 - 4.2e-37 127.1 1.1 4.2e-37 127.1 1.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 CRG83563.1 - 3e-26 91.8 0.0 5.7e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 CRG83563.1 - 2.4e-22 79.3 0.0 1.9e-21 76.4 0.0 2.6 2 1 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 CRG83563.1 - 3.8e-18 65.8 23.7 3.8e-18 65.8 23.7 6.4 6 2 0 6 6 6 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 CRG83563.1 - 1.3e-07 32.4 3.6 3.9e-06 27.7 3.6 3.3 1 1 0 1 1 1 1 HHH domain SH2 PF00017.24 CRG83563.1 - 2.2e-06 27.7 0.0 6.7e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 CRG83563.1 - 0.0014 18.9 0.0 0.0051 17.0 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif Tex_N PF09371.10 CRG83563.1 - 0.063 12.9 7.5 0.18 11.5 0.0 4.1 4 0 0 4 4 4 0 Tex-like protein N-terminal domain Pkinase PF00069.25 CRG83564.1 - 4.6e-64 216.3 0.0 5.9e-64 216.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83564.1 - 8.9e-36 123.5 0.0 1.2e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG83564.1 - 8.1e-06 24.9 0.2 2.1e-05 23.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CRG83564.1 - 0.0016 17.8 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 CRG83564.1 - 0.019 14.0 0.0 0.03 13.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 CRG83564.1 - 0.079 11.9 0.0 0.079 11.9 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 CRG83564.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family SPX PF03105.19 CRG83564.1 - 0.88 9.4 16.5 1.3 8.8 16.5 1.2 1 0 0 1 1 1 0 SPX domain Abhydrolase_3 PF07859.13 CRG83565.1 - 2e-65 220.6 0.1 2.9e-65 220.1 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CRG83565.1 - 6.7e-09 35.2 0.2 1.9e-08 33.6 0.2 1.6 1 1 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 CRG83565.1 - 1.1e-05 24.5 0.0 1.6e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 CRG83565.1 - 0.00022 20.8 0.5 0.00046 19.7 0.0 1.8 2 1 0 2 2 2 1 Prolyl oligopeptidase family Ribonuc_L-PSP PF01042.21 CRG83566.1 - 5.1e-39 133.0 0.0 5.5e-39 132.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Fungal_trans PF04082.18 CRG83567.1 - 2e-48 164.8 0.0 3.1e-48 164.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 CRG83567.1 - 0.00045 20.5 1.2 0.00045 20.5 1.2 4.2 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 CRG83567.1 - 0.00049 20.4 17.2 0.00061 20.1 1.0 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG83567.1 - 0.019 15.8 0.7 0.019 15.8 0.7 4.3 4 0 0 4 4 4 0 C2H2-type zinc finger Oxidored_FMN PF00724.20 CRG83568.1 - 5e-94 315.4 0.0 5.7e-94 315.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family AP_endonuc_2 PF01261.24 CRG83568.1 - 0.0017 17.9 0.2 3.1 7.2 0.0 3.0 1 1 2 3 3 3 2 Xylose isomerase-like TIM barrel Flavin_Reduct PF01613.18 CRG83569.1 - 5.6e-20 72.0 0.0 8.1e-20 71.4 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain UbiD PF01977.16 CRG83569.1 - 0.086 11.7 0.0 0.12 11.2 0.0 1.1 1 0 0 1 1 1 0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CRAL_TRIO PF00650.20 CRG83570.1 - 6.5e-41 139.7 0.0 9.8e-41 139.1 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG83570.1 - 1.2e-09 38.2 0.1 2.7e-09 37.1 0.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CRG83570.1 - 5.5e-07 29.8 0.0 1e-06 29.0 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain DUF2400 PF09674.10 CRG83571.1 - 0.2 11.7 4.1 0.063 13.3 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) Hydin_ADK PF17213.3 CRG83571.1 - 4.2 7.6 16.2 0.32 11.2 1.2 2.7 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain ECR1_N PF14382.6 CRG83572.1 - 1.3e-13 50.5 0.7 2.9e-13 49.4 0.7 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 CRG83572.1 - 6.8e-06 26.3 0.3 1.4e-05 25.4 0.3 1.5 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 CRG83572.1 - 0.014 16.0 0.8 0.54 10.9 0.1 2.7 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 Pkinase PF00069.25 CRG83573.1 - 1.9e-12 47.1 0.0 2.3e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83573.1 - 8.9e-10 38.3 0.0 1.1e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG83573.1 - 0.03 13.7 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 CRG83573.1 - 0.087 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG83573.1 - 0.14 12.0 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family K_channel_TID PF07941.11 CRG83574.1 - 0.017 15.6 6.5 0.017 15.6 6.5 2.8 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain SNARE_assoc PF09335.11 CRG83574.1 - 0.028 14.9 0.1 0.04 14.4 0.1 1.2 1 0 0 1 1 1 0 SNARE associated Golgi protein Alpha-amylase_C PF02806.18 CRG83574.1 - 0.083 13.4 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 Alpha amylase, C-terminal all-beta domain Sugar_tr PF00083.24 CRG83575.1 - 3.4e-120 402.0 16.9 5.2e-120 401.4 16.9 1.2 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83575.1 - 9.2e-29 100.5 63.6 1.7e-24 86.4 37.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Na_Ca_ex PF01699.24 CRG83576.1 - 3.8e-27 95.1 23.5 1.2e-13 51.3 6.5 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF4131 PF13567.6 CRG83576.1 - 0.032 13.9 8.9 0.5 10.0 3.1 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4131) COX2_TM PF02790.15 CRG83576.1 - 8.2 6.7 10.3 0.57 10.4 0.1 3.7 4 0 0 4 4 4 0 Cytochrome C oxidase subunit II, transmembrane domain Acetyltransf_3 PF13302.7 CRG83577.1 - 2.8e-31 109.0 0.0 3.3e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG83577.1 - 3.4e-08 33.7 0.0 5.1e-08 33.2 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CRG83577.1 - 0.00021 21.0 0.0 0.001 18.7 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CRG83577.1 - 0.013 15.6 0.0 0.038 14.1 0.0 1.7 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG83577.1 - 0.013 15.4 0.0 0.033 14.2 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein PUB PF09409.10 CRG83577.1 - 0.098 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 PUB domain HMGL-like PF00682.19 CRG83578.1 - 4.4e-43 147.8 0.0 6.5e-43 147.2 0.0 1.3 1 0 0 1 1 1 1 HMGL-like ECH_1 PF00378.20 CRG83578.1 - 2.7e-25 89.1 0.0 4.5e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG83578.1 - 1.6e-17 64.0 0.0 2.5e-17 63.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CoA_transf_3 PF02515.17 CRG83579.1 - 7e-51 173.5 0.0 1e-50 172.9 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III Methyltransf_23 PF13489.6 CRG83579.1 - 6.1e-20 71.7 0.0 1.2e-19 70.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83579.1 - 4.6e-09 36.9 0.0 1.5e-08 35.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG83579.1 - 1.9e-08 34.2 0.1 2e-07 31.0 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG83579.1 - 5.9e-07 30.1 0.0 5.9e-06 26.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83579.1 - 7.4e-06 26.5 0.0 4.6e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain HTH_20 PF12840.7 CRG83579.1 - 0.00015 21.7 0.2 0.048 13.7 0.1 3.2 3 0 0 3 3 3 1 Helix-turn-helix domain Methyltransf_4 PF02390.17 CRG83579.1 - 0.0087 15.5 0.1 0.04 13.4 0.0 2.0 2 1 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 CRG83579.1 - 0.028 14.0 0.0 0.069 12.7 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain PhyH PF05721.13 CRG83580.1 - 2.2e-28 100.0 0.0 1.5e-27 97.2 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 CRG83580.1 - 0.11 13.4 0.0 0.18 12.7 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Ino80_Iec3 PF14612.6 CRG83581.1 - 6e-75 253.0 2.8 8.6e-75 252.4 2.8 1.2 1 0 0 1 1 1 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling RRM_1 PF00076.22 CRG83582.1 - 9.5e-25 86.2 0.2 2.3e-14 53.0 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG83582.1 - 0.0016 18.4 0.1 0.063 13.3 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 CRG83582.1 - 0.0016 18.5 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif Spt5_N PF11942.8 CRG83582.1 - 0.011 16.7 9.8 0.028 15.4 9.8 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal eIF-3c_N PF05470.12 CRG83582.1 - 1.3 7.2 7.4 1.9 6.7 7.4 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus CDC45 PF02724.14 CRG83582.1 - 3.5 5.8 10.1 6.9 4.8 10.1 1.4 1 0 0 1 1 1 0 CDC45-like protein Btz PF09405.10 CRG83583.1 - 1.6e-31 109.2 2.2 1.6e-31 109.2 2.2 2.2 2 0 0 2 2 2 1 CASC3/Barentsz eIF4AIII binding Nop14 PF04147.12 CRG83583.1 - 8.4 4.5 6.3 12 4.0 6.3 1.1 1 0 0 1 1 1 0 Nop14-like family N_BRCA1_IG PF16158.5 CRG83584.1 - 4.9e-30 104.3 0.1 4.9e-30 104.3 0.1 2.0 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 CRG83584.1 - 1.9e-20 72.4 60.1 4.7e-07 29.5 6.5 4.4 4 0 0 4 4 4 4 Zinc finger, ZZ type C1_2 PF03107.16 CRG83584.1 - 6.9e-05 23.1 50.7 0.055 13.8 5.1 4.6 4 0 0 4 4 4 4 C1 domain Trypan_PARP PF05887.11 CRG83584.1 - 0.2 11.7 12.6 0.47 10.4 12.6 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TauD PF02668.16 CRG83585.1 - 3.8e-58 197.4 0.4 7.1e-58 196.5 0.4 1.5 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Bac_luciferase PF00296.20 CRG83585.1 - 2.4e-49 168.5 0.1 4.9e-49 167.5 0.1 1.4 1 0 0 1 1 1 1 Luciferase-like monooxygenase Cation_efflux PF01545.21 CRG83585.1 - 2.7e-23 82.8 11.8 3.7e-23 82.3 11.8 1.2 1 0 0 1 1 1 1 Cation efflux family DUF1589 PF07628.11 CRG83585.1 - 0.036 14.2 0.1 0.13 12.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1589) adh_short PF00106.25 CRG83586.1 - 3.1e-09 36.6 0.1 2.9e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83586.1 - 1.9e-07 30.9 0.2 3.1e-07 30.2 0.2 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83586.1 - 0.0036 17.2 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG83588.1 - 3.3e-10 40.2 0.0 4.4e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG83588.1 - 1e-06 28.4 0.1 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CRG83588.1 - 2.9e-06 27.5 0.3 8.9e-06 25.9 0.1 1.9 2 0 0 2 2 2 1 TrkA-N domain NmrA PF05368.13 CRG83588.1 - 3.7e-06 26.7 0.0 5.8e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family ApbA PF02558.16 CRG83588.1 - 0.0064 16.1 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 CRG83588.1 - 0.058 13.6 0.0 0.088 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CRG83588.1 - 0.077 13.6 0.0 0.18 12.4 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CRG83588.1 - 0.093 12.1 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 CRG83588.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG83588.1 - 0.15 11.4 0.1 0.48 9.8 0.0 1.9 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CRG83590.1 - 1.6e-20 73.4 0.0 3.4e-19 69.1 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83590.1 - 2.2e-10 40.5 0.0 4.8e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83590.1 - 5.3e-10 39.5 0.0 8.3e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF3425 PF11905.8 CRG83591.1 - 7.6e-20 71.1 0.1 1e-19 70.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) DUF4387 PF14330.6 CRG83592.1 - 4.4e-33 113.9 0.0 1.3e-32 112.3 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4387) AtuA PF07287.11 CRG83592.1 - 9.2e-17 60.8 0.0 4.8e-16 58.4 0.0 1.8 1 1 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA PFK PF00365.20 CRG83592.1 - 0.059 12.7 0.0 0.091 12.1 0.0 1.2 1 0 0 1 1 1 0 Phosphofructokinase Fungal_trans PF04082.18 CRG83593.1 - 7.7e-07 28.4 1.6 3.6e-06 26.2 0.3 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain TLD PF07534.16 CRG83594.1 - 2.4e-09 37.5 0.0 4.5e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 TLD LRAT PF04970.13 CRG83595.1 - 0.00062 20.1 0.1 0.00092 19.5 0.1 1.2 1 0 0 1 1 1 1 Lecithin retinol acyltransferase CDH-cyt PF16010.5 CRG83596.1 - 1.5e-65 220.3 5.6 1.5e-65 220.3 4.1 1.9 2 0 0 2 2 2 1 Cytochrome domain of cellobiose dehydrogenase GMC_oxred_C PF05199.13 CRG83596.1 - 2e-24 86.8 0.2 4.7e-24 85.5 0.2 1.7 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CRG83596.1 - 2.4e-24 86.3 0.0 5.6e-24 85.0 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase CBM_1 PF00734.18 CRG83596.1 - 4.7e-09 36.0 10.8 4.7e-09 36.0 10.8 2.3 2 0 0 2 2 2 1 Fungal cellulose binding domain FAD_binding_2 PF00890.24 CRG83596.1 - 2.9e-08 33.2 0.5 0.0015 17.7 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Zn_clus PF00172.18 CRG83596.1 - 3.2e-05 23.9 14.0 3.2e-05 23.9 14.0 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_8 PF13450.6 CRG83596.1 - 0.00017 21.7 0.0 0.00048 20.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG83596.1 - 0.00023 20.9 0.1 0.0012 18.5 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG83596.1 - 0.0027 17.0 0.1 0.015 14.5 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG83596.1 - 0.0052 16.2 0.0 0.067 12.5 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG83596.1 - 0.0061 17.1 0.0 1.4 9.5 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG83596.1 - 0.0071 15.1 0.0 0.01 14.5 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Fungal_trans_2 PF11951.8 CRG83596.1 - 0.012 14.5 0.2 0.019 13.8 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Lycopene_cycl PF05834.12 CRG83596.1 - 0.085 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG83596.1 - 0.1 11.8 0.6 0.22 10.7 0.6 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_4 PF01565.23 CRG83597.1 - 2.8e-27 95.2 0.5 5e-27 94.3 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG83597.1 - 0.00084 19.4 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like NmrA PF05368.13 CRG83599.1 - 5.7e-22 78.4 0.1 6.9e-22 78.1 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG83599.1 - 7.3e-14 52.1 0.0 1.5e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CRG83599.1 - 0.0027 16.9 0.1 0.62 9.1 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain Shikimate_DH PF01488.20 CRG83599.1 - 0.056 13.5 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AP_endonuc_2 PF01261.24 CRG83600.1 - 3e-06 26.8 0.0 4.7e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF440 PF04269.12 CRG83600.1 - 0.086 13.1 0.1 0.22 11.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF440 ADH_N PF08240.12 CRG83601.1 - 1.3e-39 134.4 0.9 4.1e-27 94.2 0.1 2.8 2 0 0 2 2 2 2 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG83601.1 - 5.1e-28 97.7 5.3 1.9e-19 69.9 0.5 2.6 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG83601.1 - 2e-20 74.2 0.0 8.2e-18 65.7 0.1 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG83601.1 - 1e-06 28.4 0.5 0.026 14.0 0.0 3.3 3 0 0 3 3 3 3 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CRG83601.1 - 0.00054 19.3 3.7 0.0027 17.0 0.3 2.9 3 0 0 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 CRG83601.1 - 0.0011 17.7 0.7 0.0041 15.9 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein ADH_N_assoc PF13823.6 CRG83601.1 - 0.018 14.9 1.1 0.042 13.8 1.1 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated FAD_binding_3 PF01494.19 CRG83601.1 - 0.13 11.5 0.1 0.27 10.5 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 CRG83601.1 - 0.13 12.5 0.2 0.47 10.7 0.1 1.9 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_2 PF00891.18 CRG83602.1 - 8.3e-21 74.2 0.0 1.2e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_16 PF10294.9 CRG83602.1 - 0.067 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_25 PF13649.6 CRG83602.1 - 0.083 13.6 0.0 0.2 12.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Arylsulfotran_2 PF14269.6 CRG83603.1 - 4.6e-54 183.8 8.4 7.3e-54 183.2 8.4 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) MFS_1 PF07690.16 CRG83603.1 - 9.3e-20 70.8 33.6 9.3e-20 70.8 33.6 3.0 1 1 2 3 3 3 1 Major Facilitator Superfamily Arylsulfotrans PF05935.11 CRG83603.1 - 1.4e-19 70.2 6.0 7.4e-18 64.6 6.0 2.7 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) MLANA PF14991.6 CRG83603.1 - 3.7e-05 24.0 0.0 7.5e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Protein melan-A DUF485 PF04341.12 CRG83603.1 - 0.038 13.9 0.1 0.038 13.9 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function, DUF485 MAS20 PF02064.15 CRG83603.1 - 0.17 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor Sulfotransfer_4 PF17784.1 CRG83604.1 - 1.7e-73 247.0 0.0 2.2e-73 246.7 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CRG83604.1 - 2.7e-05 24.7 0.1 0.00055 20.4 0.1 2.2 1 1 1 2 2 2 1 Sulfotransferase family p450 PF00067.22 CRG83605.1 - 1.3e-43 149.5 0.0 1.9e-43 148.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_10 PF13460.6 CRG83606.1 - 1.3e-11 44.8 1.1 2.5e-11 43.8 0.3 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CRG83606.1 - 4.7e-10 39.4 0.0 5.8e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family DapB_N PF01113.20 CRG83606.1 - 9.8e-06 25.7 1.2 1.4e-05 25.2 0.4 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 CRG83606.1 - 3e-05 24.3 0.1 6.8e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG83606.1 - 0.0007 19.1 0.1 0.0019 17.7 0.1 1.6 1 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 CRG83606.1 - 0.0019 18.7 0.2 0.0041 17.7 0.2 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 CRG83606.1 - 0.0039 17.6 0.1 0.0076 16.7 0.1 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 CRG83606.1 - 0.0061 17.4 0.1 0.01 16.7 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold 3Beta_HSD PF01073.19 CRG83606.1 - 0.023 13.7 0.1 0.035 13.1 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 CRG83606.1 - 0.12 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CoA_binding PF02629.19 CRG83606.1 - 0.61 10.8 2.1 2 9.1 1.8 2.1 2 1 0 2 2 2 0 CoA binding domain DIOX_N PF14226.6 CRG83607.1 - 1.4e-16 61.3 0.0 2.8e-15 57.1 0.0 2.2 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG83607.1 - 2.7e-16 59.9 0.0 9.9e-16 58.1 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 CRG83608.1 - 8.3e-08 32.2 11.0 1.7e-07 31.2 11.0 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Xan_ur_permease PF00860.20 CRG83609.1 - 0.027 13.2 0.4 0.027 13.2 0.4 1.5 2 0 0 2 2 2 0 Permease family CRAL_TRIO PF00650.20 CRG83610.1 - 3.7e-44 150.3 0.0 9e-44 149.0 0.0 1.7 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG83610.1 - 7.4e-11 42.1 0.1 2.3e-10 40.5 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CRG83610.1 - 2.1e-07 31.1 0.0 4.1e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain SRP_SPB PF02978.19 CRG83610.1 - 0.11 13.2 0.4 0.25 12.0 0.4 1.6 1 0 0 1 1 1 0 Signal peptide binding domain CSTF2_hinge PF14327.6 CRG83610.1 - 0.49 10.9 3.3 7 7.2 0.0 3.2 3 1 1 4 4 4 0 Hinge domain of cleavage stimulation factor subunit 2 SKG6 PF08693.10 CRG83611.1 - 0.00089 18.6 0.0 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 CRG83611.1 - 0.0077 15.7 0.1 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity DUF4690 PF15756.5 CRG83611.1 - 0.069 13.8 1.5 2.2 8.9 0.3 2.7 1 1 1 2 2 2 0 Small Novel Rich in Cartilage Granulin PF00396.18 CRG83611.1 - 0.34 11.3 6.8 3.7 8.0 6.9 2.4 1 1 0 1 1 1 0 Granulin Mannitol_dh_C PF08125.13 CRG83612.1 - 1.7e-79 266.8 0.0 2.9e-79 266.0 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 CRG83612.1 - 4.7e-43 146.9 0.0 8.1e-43 146.2 0.0 1.4 1 0 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain NAGLU PF05089.12 CRG83613.1 - 9e-121 402.9 7.5 1.3e-120 402.3 7.5 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 CRG83613.1 - 9.4e-69 231.9 6.8 1.6e-68 231.1 6.8 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 CRG83613.1 - 9e-20 70.2 0.0 2.4e-19 68.9 0.0 1.8 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Asp PF00026.23 CRG83614.1 - 3.7e-28 98.9 1.3 5.5e-28 98.3 1.3 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CRG83614.1 - 0.012 16.3 2.1 0.031 14.9 0.2 2.4 2 0 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 CRG83614.1 - 0.042 14.4 1.0 0.11 13.1 0.0 2.2 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Shikimate_DH PF01488.20 CRG83615.1 - 0.00099 19.2 0.0 0.0016 18.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG83615.1 - 0.12 12.6 0.0 1 9.6 0.0 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AP_endonuc_2 PF01261.24 CRG83616.1 - 1.3e-28 99.9 0.0 1.7e-28 99.5 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Carot_N PF09150.10 CRG83616.1 - 0.097 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Orange carotenoid protein, N-terminal Zn_clus PF00172.18 CRG83617.1 - 1.4e-10 41.1 11.7 2.4e-10 40.4 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG83617.1 - 8.8e-05 21.7 0.3 0.00036 19.6 0.3 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain DHquinase_I PF01487.15 CRG83618.1 - 7.3e-20 72.2 0.0 1.2e-19 71.4 0.0 1.4 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 CRG83618.1 - 1.2e-19 70.3 0.0 2.7e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 CRG83618.1 - 3.4e-09 37.0 0.0 6.1e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate kinase Shikimate_DH PF01488.20 CRG83618.1 - 7.2e-08 32.6 0.0 2.8e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 CRG83618.1 - 0.0027 17.4 0.0 0.0048 16.6 0.0 1.4 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 CRG83618.1 - 0.008 16.4 0.0 0.017 15.3 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CRG83618.1 - 0.013 16.1 0.0 0.04 14.5 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 CRG83618.1 - 0.035 13.0 0.1 0.056 12.4 0.1 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family DHquinase_II PF01220.19 CRG83619.1 - 8e-63 210.2 0.1 9.1e-63 210.0 0.1 1.0 1 0 0 1 1 1 1 Dehydroquinase class II TraI_2B PF18340.1 CRG83619.1 - 0.19 11.8 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 DNA relaxase TraI 2B/2B-like domain ABM PF03992.16 CRG83620.1 - 0.00028 20.9 0.0 0.023 14.8 0.0 2.1 2 0 0 2 2 2 2 Antibiotic biosynthesis monooxygenase Dabb PF07876.12 CRG83620.1 - 0.082 13.5 0.0 0.11 13.2 0.0 1.5 1 1 0 1 1 1 0 Stress responsive A/B Barrel Domain ADH_zinc_N PF00107.26 CRG83621.1 - 5.3e-12 45.8 1.1 2.2e-11 43.9 0.2 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG83621.1 - 4.9e-07 29.6 0.3 1e-06 28.5 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CRG83621.1 - 0.037 13.5 0.1 0.076 12.5 0.1 1.5 1 0 0 1 1 1 0 short chain dehydrogenase Zn_clus PF00172.18 CRG83622.1 - 1.3e-05 25.2 7.0 2.5e-05 24.3 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG83622.1 - 0.0002 20.5 0.4 0.00034 19.7 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_N PF08240.12 CRG83623.1 - 5.6e-10 39.1 0.1 2.9e-08 33.5 0.0 2.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG83623.1 - 1.6e-08 34.6 0.0 3e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG83623.1 - 0.0011 20.0 0.0 0.0022 19.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG83623.1 - 0.0027 17.2 0.0 0.0042 16.6 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Semialdhyde_dh PF01118.24 CRG83623.1 - 0.051 14.0 0.0 0.081 13.4 0.0 1.3 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Sugar_tr PF00083.24 CRG83625.1 - 7.1e-81 272.4 22.6 1e-80 271.8 22.6 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter Phytase-like PF13449.6 CRG83625.1 - 2.9e-40 139.0 0.0 4.6e-40 138.4 0.0 1.3 1 0 0 1 1 1 1 Esterase-like activity of phytase MFS_1 PF07690.16 CRG83625.1 - 9.3e-22 77.4 35.3 5.7e-16 58.4 13.1 2.5 2 0 0 2 2 2 2 Major Facilitator Superfamily GFO_IDH_MocA PF01408.22 CRG83625.1 - 2.6e-18 67.0 0.0 5.3e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold COX14 PF14880.6 CRG83625.1 - 0.25 11.2 0.8 26 4.8 0.0 2.6 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF485 PF04341.12 CRG83625.1 - 1.7 8.7 6.1 9.4 6.3 0.6 3.6 3 0 0 3 3 3 0 Protein of unknown function, DUF485 PhyH PF05721.13 CRG83626.1 - 1.2e-08 35.5 0.2 5.5e-08 33.3 0.2 2.0 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Glyco_hydro_3 PF00933.21 CRG83627.1 - 4.1e-65 220.3 0.0 5.5e-65 219.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 CRG83627.1 - 2.9e-06 27.5 0.0 2.9e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG83627.1 - 3.7e-05 24.1 0.1 0.00043 20.6 0.0 2.7 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG83627.1 - 0.00057 19.8 0.0 0.0014 18.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG83627.1 - 0.031 14.4 0.0 0.069 13.3 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase UPF0181 PF03701.14 CRG83627.1 - 0.14 11.9 1.5 0.32 10.6 1.5 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0181) Asparaginase_II PF06089.12 CRG83628.1 - 9.4e-57 192.4 0.0 1.5e-56 191.8 0.0 1.2 1 0 0 1 1 1 1 L-asparaginase II NDT80_PhoG PF05224.12 CRG83628.1 - 2.6e-14 53.9 0.0 5.2e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Melibiase_2 PF16499.5 CRG83629.1 - 1.1e-58 198.7 1.6 2.4e-58 197.6 1.6 1.6 1 1 0 1 1 1 1 Alpha galactosidase A Ricin_B_lectin PF00652.22 CRG83629.1 - 3.8e-12 46.6 0.4 6.4e-12 45.8 0.4 1.3 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Melibiase_C PF17801.1 CRG83629.1 - 7.7e-12 45.1 1.2 2e-11 43.8 0.1 2.2 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 CRG83629.1 - 0.0024 16.9 0.0 0.0043 16.1 0.0 1.3 1 0 0 1 1 1 1 Melibiase UCR_6-4kD PF08997.10 CRG83629.1 - 0.057 13.4 0.6 0.16 11.9 0.6 1.7 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Melibiase_2_C PF17450.2 CRG83629.1 - 0.077 13.2 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain DUF3425 PF11905.8 CRG83630.1 - 2.7e-18 66.1 2.3 4.3e-18 65.5 2.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Spc7 PF08317.11 CRG83630.1 - 0.013 14.4 1.6 0.019 13.8 1.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Prefoldin PF02996.17 CRG83630.1 - 0.1 12.5 1.9 0.17 11.8 1.9 1.4 1 0 0 1 1 1 0 Prefoldin subunit Fmp27_WPPW PF10359.9 CRG83630.1 - 0.11 11.3 0.9 0.15 10.8 0.9 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain TRPM_tetra PF16519.5 CRG83630.1 - 0.14 12.3 2.1 0.22 11.6 2.1 1.3 1 0 0 1 1 1 0 Tetramerisation domain of TRPM LCD1 PF09798.9 CRG83630.1 - 0.21 10.0 0.6 0.27 9.7 0.6 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein CLZ PF16526.5 CRG83630.1 - 0.23 11.8 6.1 0.41 11.0 6.1 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phlebovirus_NSM PF07246.11 CRG83630.1 - 0.46 9.8 3.0 0.7 9.2 3.0 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M bZIP_Maf PF03131.17 CRG83630.1 - 2.6 8.6 13.9 4.1 8.0 13.9 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF4140 PF13600.6 CRG83630.1 - 4.2 7.9 5.2 7.8 7.0 5.2 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Amidohydro_2 PF04909.14 CRG83631.1 - 1.6e-37 129.9 0.3 1.9e-37 129.6 0.3 1.1 1 0 0 1 1 1 1 Amidohydrolase Esterase_phd PF10503.9 CRG83632.1 - 1.4e-07 31.3 0.0 2.6e-07 30.4 0.0 1.5 2 0 0 2 2 2 1 Esterase PHB depolymerase Hydrolase_4 PF12146.8 CRG83632.1 - 0.0057 15.9 0.0 0.033 13.5 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CRG83632.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1100 PF06500.11 CRG83632.1 - 0.077 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_1 PF00561.20 CRG83632.1 - 0.11 12.2 0.0 0.24 11.0 0.0 1.5 1 1 1 2 2 2 0 alpha/beta hydrolase fold DLH PF01738.18 CRG83632.1 - 0.11 12.1 0.0 0.43 10.1 0.0 1.9 2 1 0 2 2 2 0 Dienelactone hydrolase family ArAE_2_N PF10337.9 CRG83633.1 - 1.5e-107 360.6 9.6 5.4e-104 348.8 3.5 4.1 2 1 1 3 3 3 3 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 CRG83633.1 - 3.5e-62 210.2 0.0 6.9e-62 209.3 0.0 1.5 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 CRG83633.1 - 7.3e-08 32.6 13.8 7.3e-08 32.6 13.8 3.4 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.8 CRG83633.1 - 0.0065 15.4 2.3 0.012 14.5 2.3 1.3 1 0 0 1 1 1 1 Aluminium activated malate transporter Shikimate_dh_N PF08501.11 CRG83634.1 - 5.2e-18 65.1 0.0 1.2e-17 63.9 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain ADH_zinc_N PF00107.26 CRG83635.1 - 1.5e-14 54.1 0.1 2.5e-14 53.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG83635.1 - 8.1e-11 41.8 0.0 2.7e-10 40.1 0.0 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CRG83635.1 - 6.8e-05 22.4 0.1 0.00011 21.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase AlaDh_PNT_C PF01262.21 CRG83635.1 - 0.0038 16.6 0.6 0.1 11.9 0.2 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_2 PF16884.5 CRG83635.1 - 0.039 13.8 0.0 0.092 12.7 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase EBP PF05241.12 CRG83636.1 - 1.7e-58 197.0 13.6 2e-58 196.8 13.6 1.0 1 0 0 1 1 1 1 Emopamil binding protein GARP PF16731.5 CRG83637.1 - 0.14 11.8 6.0 0.064 12.9 1.9 2.2 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Fungal_trans PF04082.18 CRG83638.1 - 1.6e-06 27.3 0.9 2.9e-06 26.5 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain TBCC_N PF16752.5 CRG83638.1 - 0.023 15.1 0.6 1.1 9.7 0.1 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DKCLD PF08068.12 CRG83638.1 - 0.16 12.1 0.0 0.35 11.0 0.0 1.5 1 0 0 1 1 1 0 DKCLD (NUC011) domain Glyco_hydro_53 PF07745.13 CRG83640.1 - 4.9e-102 341.4 0.1 6.4e-102 341.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 PEP_mutase PF13714.6 CRG83640.1 - 1.3e-39 136.1 0.0 1.8e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CRG83640.1 - 3.4e-21 75.3 0.1 5.3e-21 74.7 0.1 1.2 1 0 0 1 1 1 1 Isocitrate lyase family Zn_clus PF00172.18 CRG83641.1 - 3.8e-06 26.9 11.2 7e-06 26.1 11.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4636 PF15468.6 CRG83641.1 - 0.24 11.1 1.6 0.4 10.3 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) Aldo_ket_red PF00248.21 CRG83642.1 - 6.1e-55 186.5 0.0 7.8e-55 186.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 CRG83643.1 - 2e-61 208.1 0.0 3.1e-61 207.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG83643.1 - 9.8e-19 67.5 31.8 9.8e-19 67.5 31.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily CENP-B_N PF04218.13 CRG83643.1 - 0.12 12.1 0.1 0.24 11.1 0.1 1.5 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain DUF4131 PF13567.6 CRG83643.1 - 0.15 11.7 0.1 0.15 11.7 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4131) TMEM238 PF15125.6 CRG83643.1 - 2.1 8.6 6.8 0.19 11.9 0.8 2.4 2 0 0 2 2 2 0 TMEM238 protein family ATPase_gene1 PF09527.10 CRG83643.1 - 5.8 7.2 16.5 13 6.1 0.0 3.8 3 0 0 3 3 3 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Bac_luciferase PF00296.20 CRG83644.1 - 4.2e-62 210.4 2.8 6.7e-62 209.7 2.8 1.3 1 0 0 1 1 1 1 Luciferase-like monooxygenase MFS_1 PF07690.16 CRG83644.1 - 2.8e-28 98.9 14.8 4.3e-28 98.2 14.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily BT1 PF03092.16 CRG83644.1 - 0.019 13.2 0.2 0.019 13.2 0.2 1.9 2 0 0 2 2 2 0 BT1 family DUF4668 PF15701.5 CRG83644.1 - 0.058 13.2 0.0 0.19 11.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) Sugar_tr PF00083.24 CRG83644.1 - 0.4 9.5 21.7 0.015 14.2 6.5 2.7 3 0 0 3 3 3 0 Sugar (and other) transporter CFEM PF05730.11 CRG83645.1 - 6.2e-13 48.6 11.1 1e-12 47.9 11.1 1.4 1 0 0 1 1 1 1 CFEM domain PLAC8 PF04749.17 CRG83646.1 - 9.2e-21 74.7 22.1 1.1e-20 74.5 22.1 1.1 1 0 0 1 1 1 1 PLAC8 family Nop25 PF09805.9 CRG83647.1 - 0.044 14.3 3.3 0.045 14.2 3.3 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) RP-C_C PF11800.8 CRG83647.1 - 0.12 12.4 3.4 0.12 12.4 3.4 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Ndc1_Nup PF09531.10 CRG83647.1 - 0.22 10.2 1.5 0.24 10.0 1.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SelP_N PF04592.14 CRG83647.1 - 0.46 9.8 8.2 0.47 9.8 8.2 1.0 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DIOX_N PF14226.6 CRG83649.1 - 4.9e-12 46.7 0.0 7.8e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal B-block_TFIIIC PF04182.12 CRG83650.1 - 4.5e-19 68.4 0.0 1.4e-18 66.8 0.0 1.9 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC MarR_2 PF12802.7 CRG83650.1 - 0.019 14.8 0.5 0.3 11.0 0.1 2.8 2 0 0 2 2 2 0 MarR family Ntox47 PF15540.6 CRG83650.1 - 0.084 13.2 0.1 0.4 11.0 0.1 2.1 2 0 0 2 2 2 0 Bacterial toxin 47 MarR PF01047.22 CRG83650.1 - 0.14 12.1 0.0 0.79 9.7 0.0 2.2 2 0 0 2 2 2 0 MarR family SMAP PF15477.6 CRG83650.1 - 0.24 12.4 1.8 0.71 10.9 0.8 2.3 2 0 0 2 2 2 0 Small acidic protein family UQ_con PF00179.26 CRG83651.1 - 9.1e-20 70.7 0.0 1.4e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CRG83651.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B DUF3439 PF11921.8 CRG83651.1 - 0.15 12.0 7.3 0.26 11.2 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 CRG83651.1 - 0.16 11.9 12.7 0.22 11.5 12.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 CRG83651.1 - 7.4 4.6 8.6 9.8 4.2 8.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Fungal_trans_2 PF11951.8 CRG83652.1 - 5.9e-07 28.6 0.0 8.5e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain 3Beta_HSD PF01073.19 CRG83653.1 - 5.9e-14 51.7 0.0 9.2e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG83653.1 - 4.8e-12 45.9 1.0 2.3e-11 43.6 1.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG83653.1 - 1.2e-07 31.4 0.0 1.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG83653.1 - 1.3e-07 31.7 0.1 2.3e-07 30.9 0.1 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG83653.1 - 1.1e-06 28.4 0.2 7.7e-06 25.6 0.2 1.9 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 CRG83653.1 - 1e-05 24.8 0.0 0.00013 21.2 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 CRG83653.1 - 0.0031 16.7 0.0 0.0043 16.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CRG83653.1 - 0.053 13.0 0.3 1.7 8.1 0.1 2.5 2 1 0 2 2 2 0 short chain dehydrogenase KR PF08659.10 CRG83653.1 - 0.15 12.0 0.2 3.1 7.7 0.2 2.5 2 1 0 2 2 2 0 KR domain DHHC PF01529.20 CRG83654.1 - 1.2e-37 129.0 9.3 2.1e-37 128.2 9.3 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase Rhomboid PF01694.22 CRG83655.1 - 1.1e-34 119.6 12.0 1.1e-34 119.6 12.0 2.1 3 0 0 3 3 3 1 Rhomboid family FeThRed_B PF02943.15 CRG83655.1 - 0.044 13.8 0.2 0.079 13.0 0.2 1.3 1 0 0 1 1 1 0 Ferredoxin thioredoxin reductase catalytic beta chain DUF2177 PF09945.9 CRG83655.1 - 0.95 9.6 9.1 0.22 11.6 1.6 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2177) TauE PF01925.19 CRG83655.1 - 1.1 8.9 17.1 0.26 10.9 10.4 2.2 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE SPT_ssu-like PF11779.8 CRG83656.1 - 1.1e-16 60.1 3.9 1.7e-16 59.6 3.9 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Kinetochor_Ybp2 PF08568.10 CRG83657.1 - 6.4e-140 467.6 0.1 7.3e-140 467.4 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin Ribonucleas_3_3 PF14622.6 CRG83658.1 - 1.4e-08 34.9 0.0 2e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CRG83658.1 - 0.0016 19.1 0.0 0.003 18.1 0.0 1.5 1 1 0 1 1 1 1 Ribonuclease III domain PLDc_2 PF13091.6 CRG83659.1 - 8.8e-19 67.7 0.0 3.6e-07 30.1 0.0 3.7 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 CRG83659.1 - 2.5e-15 55.9 0.8 8.7e-07 28.9 0.2 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Cyanate_lyase PF02560.14 CRG83660.1 - 1.9e-29 101.3 0.0 2.7e-29 100.8 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain YycC PF14174.6 CRG83660.1 - 0.042 13.6 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 YycC-like protein ORC6 PF05460.13 CRG83660.1 - 0.054 12.8 0.0 0.058 12.7 0.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) HTH_31 PF13560.6 CRG83660.1 - 0.1 13.0 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain zf-C2H2_4 PF13894.6 CRG83661.1 - 4.2e-08 33.4 15.7 0.5 11.3 0.1 5.8 6 0 0 6 6 6 4 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG83661.1 - 1.9e-07 31.1 12.3 0.043 14.3 0.1 5.5 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CRG83661.1 - 3.7e-05 23.9 8.0 0.8 10.1 1.5 4.9 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG83661.1 - 0.022 15.1 6.9 44 4.7 0.1 4.9 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 CRG83661.1 - 0.06 13.2 1.8 3.2 7.7 0.1 3.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_6 PF13912.6 CRG83661.1 - 0.062 13.3 0.4 0.062 13.3 0.4 4.0 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CRG83661.1 - 0.071 13.4 9.6 0.12 12.7 3.9 3.0 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 CRG83661.1 - 0.5 11.1 7.9 30 5.3 0.0 4.0 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 CRG83661.1 - 1.2 9.5 5.2 2.2 8.6 0.6 3.1 2 1 1 3 3 3 0 C2H2-type zinc ribbon DNA_pol_B PF00136.21 CRG83665.1 - 8.1e-149 496.2 1.7 1.3e-148 495.5 1.7 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 CRG83665.1 - 3.4e-85 286.1 0.4 7.3e-85 285.1 0.4 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 CRG83665.1 - 4.7e-18 65.4 6.8 1.3e-17 64.0 6.8 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.6 CRG83665.1 - 0.0035 17.3 0.3 0.024 14.7 0.3 2.3 1 1 0 1 1 1 1 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 CRG83665.1 - 0.011 15.5 0.1 0.023 14.4 0.1 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA_pol_B_2 PF03175.13 CRG83665.1 - 0.031 13.1 0.3 0.13 11.1 0.0 2.1 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral C1_1 PF00130.22 CRG83665.1 - 0.78 9.7 10.0 0.15 12.0 1.2 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Fungal_trans_2 PF11951.8 CRG83666.1 - 1.6e-08 33.8 1.2 1.6e-08 33.8 1.2 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Pkinase PF00069.25 CRG83667.1 - 6.9e-37 127.2 0.0 3.1e-20 72.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83667.1 - 2.2e-17 63.2 0.0 4.1e-16 59.1 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 CRG83667.1 - 0.022 14.4 0.0 2 8.0 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CRG83667.1 - 0.063 12.6 0.2 0.15 11.4 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Acyl-CoA_dh_1 PF00441.24 CRG83668.1 - 7.6e-30 104.1 0.4 1.1e-29 103.6 0.4 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CRG83668.1 - 4.7e-25 88.5 0.0 1.4e-24 86.9 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CRG83668.1 - 7.3e-16 58.1 0.0 1.7e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CRG83668.1 - 4.5e-05 23.7 0.2 7.8e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Syja_N PF02383.18 CRG83669.1 - 6.3e-78 262.3 0.0 1e-77 261.6 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Tti2 PF10521.9 CRG83670.1 - 3.2e-90 302.5 3.5 4.3e-90 302.1 3.5 1.2 1 0 0 1 1 1 1 Tti2 family PolyA_pol PF01743.20 CRG83671.1 - 1.7e-23 83.4 1.4 5.3e-23 81.8 1.4 1.9 1 1 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 CRG83671.1 - 3.5e-07 29.9 0.1 1.1e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 CRG83671.1 - 4e-05 23.6 0.0 0.00015 21.8 0.0 2.0 1 0 0 1 1 1 1 tRNA nucleotidyltransferase domain 2 putative TRAPPC-Trs85 PF12739.7 CRG83672.1 - 1.5e-113 379.9 0.0 1.3e-112 376.8 0.0 1.9 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Pex14_N PF04695.13 CRG83672.1 - 5.2 7.7 7.6 4.2 8.0 0.1 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Aldedh PF00171.22 CRG83674.1 - 9.4e-144 479.4 0.0 1.1e-143 479.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Snf7 PF03357.21 CRG83675.1 - 8e-20 71.1 16.9 1.3e-19 70.5 16.4 1.6 1 1 0 1 1 1 1 Snf7 DUF4407 PF14362.6 CRG83675.1 - 0.019 14.3 17.8 0.25 10.7 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Metalloenzyme PF01676.18 CRG83675.1 - 0.058 12.8 1.0 0.092 12.1 1.0 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily D5_N PF08706.11 CRG83675.1 - 0.13 12.5 2.2 1 9.6 0.1 2.4 2 0 0 2 2 2 0 D5 N terminal like MCU PF04678.13 CRG83675.1 - 0.25 11.4 13.1 0.23 11.6 1.9 2.6 1 1 1 2 2 2 0 Mitochondrial calcium uniporter DUF2247 PF10004.9 CRG83675.1 - 0.46 10.2 7.8 0.085 12.6 2.0 2.5 2 2 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2247) COG5 PF10392.9 CRG83675.1 - 0.91 9.7 11.4 0.74 10.0 2.7 3.0 2 1 1 3 3 3 0 Golgi transport complex subunit 5 NPV_P10 PF05531.12 CRG83675.1 - 0.95 10.0 13.4 4.9e+02 1.3 9.8 3.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein YlqD PF11068.8 CRG83675.1 - 1.7 9.1 16.5 0.11 12.8 4.5 2.8 3 0 0 3 3 3 0 YlqD protein DivIC PF04977.15 CRG83675.1 - 4.5 7.1 15.8 1.4 8.7 0.1 3.2 3 0 0 3 3 3 0 Septum formation initiator DASH_Dad3 PF08656.10 CRG83675.1 - 6.1 7.0 7.6 6.9e+02 0.4 7.6 3.4 1 1 0 1 1 1 0 DASH complex subunit Dad3 Atg14 PF10186.9 CRG83675.1 - 6.5 5.7 13.4 0.073 12.2 2.6 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Z1 PF10593.9 CRG83675.1 - 9.7 5.6 11.3 13 5.2 6.0 2.8 2 1 1 3 3 3 0 Z1 domain zf-C3HC4_2 PF13923.6 CRG83676.1 - 9.7e-11 41.3 11.9 9.7e-11 41.3 11.9 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 CRG83676.1 - 1.1e-07 31.6 5.2 2.2e-07 30.6 5.2 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 CRG83676.1 - 1.8e-07 30.9 15.5 2e-07 30.8 9.9 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG83676.1 - 1.9e-07 30.9 12.4 1.9e-07 30.9 12.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG83676.1 - 9.1e-07 28.7 12.6 9.1e-07 28.7 12.6 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CRG83676.1 - 9.8e-07 28.7 10.7 9.8e-07 28.7 10.7 2.1 2 0 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CRG83676.1 - 3.8e-05 23.4 14.0 0.03 14.2 11.3 2.6 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CRG83676.1 - 4.5e-05 23.5 12.5 4.5e-05 23.5 12.5 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CRG83676.1 - 6.6e-05 23.2 12.5 6.6e-05 23.2 12.5 2.2 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 CRG83676.1 - 0.00068 19.9 5.5 0.00068 19.9 5.5 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain Mob_synth_C PF06463.13 CRG83676.1 - 0.0014 18.5 4.8 0.0035 17.3 4.8 1.6 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C zf-RING_10 PF16685.5 CRG83676.1 - 0.0037 17.4 6.2 0.0037 17.4 6.2 1.8 2 0 0 2 2 2 1 zinc RING finger of MSL2 U-box PF04564.15 CRG83676.1 - 0.0069 16.5 0.1 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 U-box domain SAP PF02037.27 CRG83676.1 - 0.0087 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 SAP domain zf-ANAPC11 PF12861.7 CRG83676.1 - 0.078 13.0 5.1 0.051 13.6 2.1 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 CRG83676.1 - 0.36 10.6 15.2 0.22 11.3 10.6 2.6 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Glyco_hydro_125 PF06824.11 CRG83677.1 - 6.1e-175 582.1 0.0 8.3e-175 581.6 0.0 1.2 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) CDC27 PF09507.10 CRG83677.1 - 4e-86 290.1 37.7 1.5e-85 288.2 37.7 1.7 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 ALAD PF00490.21 CRG83677.1 - 0.025 13.8 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 Delta-aminolevulinic acid dehydratase Pex2_Pex12 PF04757.14 CRG83678.1 - 1.8e-55 188.0 4.9 2.4e-55 187.6 4.9 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 CRG83678.1 - 3.1e-06 27.2 3.5 5.7e-06 26.4 3.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CRG83678.1 - 0.00015 22.0 2.5 0.00032 21.0 2.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CRG83678.1 - 0.00027 20.9 3.9 0.00027 20.9 3.9 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CRG83678.1 - 0.00099 18.9 3.3 0.0011 18.8 2.0 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG83678.1 - 0.0023 17.7 1.6 0.004 17.0 1.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG83678.1 - 0.0033 17.3 2.4 0.0061 16.4 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Dynamin_M PF01031.20 CRG83678.1 - 0.14 11.4 0.0 16 4.6 0.0 2.1 2 0 0 2 2 2 0 Dynamin central region RsfS PF02410.15 CRG83679.1 - 2e-10 41.0 0.0 4.2e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation NMD3 PF04981.13 CRG83680.1 - 7.5e-81 271.2 6.2 1e-80 270.7 6.2 1.2 1 0 0 1 1 1 1 NMD3 family TackOD1 PF18551.1 CRG83680.1 - 0.28 10.8 7.7 1.8 8.2 3.7 2.5 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 Maf1 PF09174.10 CRG83681.1 - 0.083 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Maf1 regulator RRM_1 PF00076.22 CRG83682.1 - 0.012 15.4 0.0 0.19 11.5 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MinC_C PF03775.16 CRG83682.1 - 0.09 12.8 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Septum formation inhibitor MinC, C-terminal domain Nop14 PF04147.12 CRG83682.1 - 5.3 5.1 24.4 0.018 13.3 10.8 2.0 2 0 0 2 2 2 0 Nop14-like family Mito_carr PF00153.27 CRG83683.1 - 4.2e-61 202.9 4.5 1.2e-20 73.3 0.1 4.1 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CRG83683.1 - 0.0035 16.6 0.0 2 7.5 0.0 2.4 2 0 0 2 2 2 2 Gammaproteobacterial serine protease Alg6_Alg8 PF03155.15 CRG83684.1 - 7.5e-170 566.0 30.5 9.4e-170 565.7 30.5 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family WAC_Acf1_DNA_bd PF10537.9 CRG83684.1 - 1.2e-37 128.5 0.7 1.2e-37 128.5 0.7 3.6 5 0 0 5 5 5 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 CRG83684.1 - 1.2e-23 83.4 0.6 1.2e-23 83.4 0.6 2.8 2 1 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 CRG83684.1 - 5.6e-14 52.2 2.3 1.3e-13 51.0 2.3 1.7 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 CRG83684.1 - 6.3e-07 28.8 0.1 1.5e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 SURF6 PF04935.12 CRG83684.1 - 0.38 10.5 19.4 0.95 9.2 19.4 1.7 1 0 0 1 1 1 0 Surfeit locus protein 6 Lectin_leg-like PF03388.13 CRG83685.1 - 4.2e-28 98.3 0.0 6.4e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Baculo_PEP_C PF04513.12 CRG83685.1 - 0.0022 18.0 2.7 0.026 14.6 0.3 2.1 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin_2 PF14523.6 CRG83685.1 - 0.021 15.2 1.9 0.6 10.5 0.2 2.2 2 0 0 2 2 2 0 Syntaxin-like protein COG5 PF10392.9 CRG83685.1 - 0.022 14.9 2.7 0.059 13.6 2.6 1.6 1 1 0 1 1 1 0 Golgi transport complex subunit 5 KLRAQ PF10205.9 CRG83685.1 - 0.062 13.5 3.0 0.1 12.8 0.3 2.1 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein ASD2 PF08687.11 CRG83685.1 - 0.11 12.1 1.8 0.23 11.0 0.3 1.9 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Spc7 PF08317.11 CRG83685.1 - 0.13 11.1 0.5 0.19 10.6 0.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Translin PF01997.16 CRG83685.1 - 0.16 12.0 0.2 0.23 11.4 0.2 1.2 1 0 0 1 1 1 0 Translin family ABC_tran_CTD PF16326.5 CRG83685.1 - 0.16 12.2 0.3 9.5 6.6 0.1 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4795 PF16043.5 CRG83685.1 - 0.21 11.2 1.2 0.45 10.1 1.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4407 PF14362.6 CRG83685.1 - 0.31 10.3 0.8 0.46 9.8 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FadA PF09403.10 CRG83685.1 - 0.37 11.3 3.2 4.2 7.9 3.2 2.1 1 1 0 1 1 1 0 Adhesion protein FadA DUF4763 PF15960.5 CRG83685.1 - 0.44 9.8 3.5 0.52 9.6 1.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) LPP PF04728.13 CRG83685.1 - 0.59 10.6 3.7 15 6.1 0.7 2.5 2 0 0 2 2 2 0 Lipoprotein leucine-zipper MscS_porin PF12795.7 CRG83685.1 - 0.61 9.6 9.2 0.99 8.9 9.2 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Cep57_CLD_2 PF14197.6 CRG83685.1 - 2.7 8.2 6.2 1.7 8.8 0.9 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 PHD PF00628.29 CRG83686.1 - 6.2e-17 61.2 24.3 3.8e-11 42.7 8.9 2.4 2 0 0 2 2 2 2 PHD-finger DUF5610 PF18433.1 CRG83686.1 - 0.017 15.6 0.6 0.048 14.2 0.6 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5610) Vps36-NZF-N PF16988.5 CRG83686.1 - 0.034 13.6 1.3 0.76 9.2 0.1 3.1 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-PHD-like PF15446.6 CRG83686.1 - 0.26 10.9 10.0 0.048 13.3 2.5 2.6 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Peptidase_M24 PF00557.24 CRG83687.1 - 9.5e-08 32.0 0.0 1.7e-07 31.1 0.0 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 Trans_coact PF16805.5 CRG83687.1 - 0.86 9.7 3.3 0.88 9.7 0.2 2.5 3 0 0 3 3 3 0 Phage late-transcription coactivator SNF5 PF04855.12 CRG83689.1 - 1.7e-64 217.9 0.0 2e-63 214.4 0.0 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 BUD22 PF09073.10 CRG83690.1 - 2.1e-07 30.7 20.4 2.1e-07 30.7 20.4 2.2 2 0 0 2 2 2 1 BUD22 HEAT_2 PF13646.6 CRG83690.1 - 0.00041 20.7 6.9 0.00072 19.9 0.2 4.5 5 1 0 5 5 5 1 HEAT repeats HEAT PF02985.22 CRG83690.1 - 0.0014 18.7 7.6 1.1 9.7 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 CRG83690.1 - 0.0021 18.1 1.4 0.064 13.3 0.0 3.7 3 2 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 DUF4299 PF14132.6 CRG83690.1 - 0.094 12.1 0.1 0.17 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) HEAT_EZ PF13513.6 CRG83690.1 - 2 9.0 5.6 26 5.5 0.1 5.0 6 0 0 6 6 6 0 HEAT-like repeat SAPS PF04499.15 CRG83690.1 - 2.9 6.6 8.4 7.1 5.3 8.4 1.6 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ribosomal_L32e PF01655.18 CRG83691.1 - 1e-48 164.2 0.2 1.4e-48 163.8 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L32 PseudoU_synth_2 PF00849.22 CRG83692.1 - 1.3e-25 90.4 0.0 2e-25 89.7 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase Auto_anti-p27 PF06677.12 CRG83692.1 - 0.0043 17.2 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) 4HBT PF03061.22 CRG83693.1 - 4e-10 39.9 0.0 5.4e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 CRG83693.1 - 8.8e-05 21.9 0.1 0.00014 21.3 0.1 1.3 1 0 0 1 1 1 1 Acyl-ACP thioesterase 4HBT_2 PF13279.6 CRG83693.1 - 0.00018 22.0 0.0 0.00023 21.7 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily polyprenyl_synt PF00348.17 CRG83695.1 - 2.5e-53 180.8 0.2 7.7e-53 179.2 0.0 1.8 2 0 0 2 2 2 1 Polyprenyl synthetase Terpene_synth_C PF03936.16 CRG83695.1 - 0.0019 17.6 0.1 0.17 11.2 0.0 2.4 2 0 0 2 2 2 2 Terpene synthase family, metal binding domain p450 PF00067.22 CRG83696.1 - 5.6e-45 153.9 0.0 2.5e-43 148.5 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 OKR_DC_1_N PF03709.15 CRG83696.1 - 0.0022 18.2 0.6 0.0037 17.5 0.6 1.3 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain p450 PF00067.22 CRG83697.1 - 1.6e-65 221.7 0.1 2e-65 221.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Transferase PF02458.15 CRG83698.1 - 1e-25 90.3 0.0 6.8e-24 84.3 0.0 2.0 2 0 0 2 2 2 2 Transferase family Glyco_hydro_108 PF05838.12 CRG83699.1 - 0.14 12.7 0.1 0.32 11.5 0.1 1.7 1 1 0 1 1 1 0 Glycosyl hydrolase 108 ketoacyl-synt PF00109.26 CRG83700.1 - 2e-69 234.0 0.0 3.3e-69 233.3 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG83700.1 - 4.8e-59 200.0 0.0 7.2e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CRG83700.1 - 2.3e-58 197.1 3.8 2.9e-58 196.8 0.3 3.0 4 0 0 4 4 4 1 KR domain Acyl_transf_1 PF00698.21 CRG83700.1 - 2.4e-52 178.4 0.1 4.4e-52 177.6 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG83700.1 - 3.9e-32 110.7 0.2 9.7e-32 109.5 0.2 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG83700.1 - 7.1e-16 58.7 0.0 2.1e-15 57.2 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG83700.1 - 7.7e-08 32.0 0.4 2.2e-07 30.5 0.1 1.9 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83700.1 - 6.2e-07 29.2 0.3 1.7e-06 27.8 0.1 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 CRG83700.1 - 3.9e-06 26.4 0.2 5.3e-05 22.7 0.1 2.6 3 0 0 3 3 3 1 Thiolase, N-terminal domain PP-binding PF00550.25 CRG83700.1 - 3.7e-05 24.0 0.1 0.00014 22.1 0.0 2.1 2 0 0 2 2 2 1 Phosphopantetheine attachment site TIR_2 PF13676.6 CRG83700.1 - 0.14 12.8 0.0 2 9.1 0.0 2.5 2 0 0 2 2 2 0 TIR domain ILVD_EDD PF00920.21 CRG83701.1 - 3.1e-154 514.4 0.0 3.5e-154 514.2 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family DnaJ_C PF01556.18 CRG83702.1 - 4e-38 130.8 0.1 5.4e-38 130.4 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CRG83702.1 - 9.4e-19 67.3 2.2 1.7e-18 66.5 2.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CRG83702.1 - 6.9e-14 52.0 16.0 1.3e-13 51.1 16.0 1.5 1 0 0 1 1 1 1 DnaJ central domain RseC_MucC PF04246.12 CRG83702.1 - 0.036 14.0 0.3 0.036 14.0 0.3 1.8 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC HicA_toxin PF07927.12 CRG83702.1 - 0.16 12.0 0.1 0.34 11.0 0.1 1.4 1 0 0 1 1 1 0 HicA toxin of bacterial toxin-antitoxin, Anti-TRAP PF15777.5 CRG83702.1 - 1.2 9.2 17.1 1.9 8.5 3.5 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-RING_10 PF16685.5 CRG83702.1 - 1.5 9.0 5.5 5.9 7.1 0.7 2.3 2 0 0 2 2 2 0 zinc RING finger of MSL2 tRNA-synt_1c PF00749.21 CRG83703.1 - 4.5e-91 305.0 0.0 6e-91 304.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain MAP65_ASE1 PF03999.12 CRG83704.1 - 2e-77 261.3 14.5 9.1e-77 259.1 8.0 2.0 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) Baculo_PEP_C PF04513.12 CRG83704.1 - 2.7 8.0 5.1 3.1 7.8 3.2 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spectrin PF00435.21 CRG83704.1 - 5.9 7.4 12.7 15 6.1 0.8 4.1 4 0 0 4 4 4 0 Spectrin repeat DUF4407 PF14362.6 CRG83704.1 - 7.2 5.9 8.4 3.5 6.9 2.6 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) JAB PF01398.21 CRG83705.1 - 6.9e-31 106.7 0.1 1.2e-30 105.9 0.1 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 CRG83705.1 - 6.3e-20 71.9 0.0 2.4e-19 70.0 0.0 2.0 1 1 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 CRG83705.1 - 0.00031 20.5 0.0 0.00054 19.7 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Oxidored_molyb PF00174.19 CRG83706.1 - 7.8e-52 175.4 0.0 1.3e-51 174.6 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 CRG83706.1 - 2.4e-35 121.6 0.4 2.4e-35 121.6 0.4 1.7 2 0 0 2 2 2 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.21 CRG83706.1 - 5.1e-24 85.0 0.5 4.9e-23 81.9 0.0 3.0 4 0 0 4 4 4 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CRG83706.1 - 1.1e-23 83.4 0.0 2.1e-23 82.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 CRG83706.1 - 4.6e-16 58.7 0.1 1.9e-15 56.7 0.1 2.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 CRG83706.1 - 0.0031 17.6 0.1 0.45 10.6 0.0 3.2 2 1 1 3 3 3 1 Ferric reductase NAD binding domain RasGEF PF00617.19 CRG83707.1 - 1.6e-58 197.8 0.1 3.1e-58 196.9 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CRG83707.1 - 1.4e-29 102.4 0.3 3e-29 101.3 0.3 1.6 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 CRG83707.1 - 1.4e-15 56.6 0.2 3.6e-15 55.3 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG83707.1 - 8.4e-13 48.0 0.1 2.5e-12 46.4 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CRG83707.1 - 6e-12 45.1 0.0 1.4e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 CRG83707.1 - 0.00024 21.1 0.0 0.00096 19.2 0.0 2.0 2 0 0 2 2 2 1 WW domain SR-25 PF10500.9 CRG83708.1 - 0.15 11.7 3.6 0.22 11.1 3.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Amidohydro_3 PF07969.11 CRG83709.1 - 5.6e-78 263.5 2.0 7.7e-78 263.0 2.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 CRG83709.1 - 1.4e-08 34.5 0.0 0.00011 21.6 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family Fungal_trans PF04082.18 CRG83710.1 - 1.9e-20 73.0 2.0 3e-20 72.4 2.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 CRG83710.1 - 1.5e-07 31.5 15.1 1.1e-05 25.6 5.8 3.1 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 CRG83710.1 - 6.1e-05 23.3 14.5 0.0048 17.3 5.2 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 CRG83710.1 - 0.062 14.0 0.3 0.57 10.9 0.1 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 CRG83710.1 - 0.078 13.9 19.5 0.12 13.3 3.9 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger PyrI_C PF02748.15 CRG83710.1 - 0.11 12.4 0.8 0.29 11.1 0.8 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 CRG83710.1 - 0.57 10.5 6.3 0.6 10.5 3.8 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 CRG83710.1 - 3.1 7.9 6.2 2.3 8.3 1.6 2.5 1 1 1 2 2 2 0 BED zinc finger CRCB PF02537.15 CRG83711.1 - 1.4e-38 131.1 12.9 4.6e-23 81.3 5.8 2.4 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) FixQ PF05545.11 CRG83712.1 - 0.16 11.9 0.1 0.25 11.3 0.1 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ MreB_Mbl PF06723.13 CRG83713.1 - 0.0018 17.2 0.0 0.021 13.6 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein ADH_zinc_N_2 PF13602.6 CRG83714.1 - 1.1e-06 29.8 0.2 3e-05 25.1 0.0 2.5 1 1 1 2 2 2 1 Zinc-binding dehydrogenase Trp_oprn_chp PF09534.10 CRG83714.1 - 0.00046 20.0 0.8 0.0012 18.7 0.8 1.7 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Ctr PF04145.15 CRG83714.1 - 0.095 13.3 0.0 0.32 11.6 0.0 1.9 1 1 0 1 1 1 0 Ctr copper transporter family Gly-zipper_Omp PF13488.6 CRG83714.1 - 0.11 12.5 4.9 0.26 11.3 4.9 1.6 1 0 0 1 1 1 0 Glycine zipper Glyco_hydro_32N PF00251.20 CRG83715.1 - 8.3e-75 252.2 1.2 9.9e-75 251.9 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 CRG83715.1 - 2.2e-28 99.2 0.1 3.4e-28 98.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Glyco_hydro_32N PF00251.20 CRG83716.1 - 9.7e-90 301.2 3.5 1.2e-89 300.9 3.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 CRG83716.1 - 3.5e-36 124.6 1.8 6.8e-36 123.7 1.8 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal CHB_HEX_C PF03174.13 CRG83716.1 - 0.11 12.5 0.1 0.28 11.2 0.1 1.7 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain Sugar_tr PF00083.24 CRG83717.1 - 2.5e-124 415.6 22.3 2.5e-124 415.6 22.3 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83717.1 - 1.5e-21 76.8 32.3 1.5e-21 76.8 32.3 3.2 2 2 1 3 3 3 2 Major Facilitator Superfamily DUF261 PF03196.13 CRG83717.1 - 0.68 10.0 3.3 0.44 10.6 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF261 Sugar_tr PF00083.24 CRG83718.1 - 2.4e-70 237.7 25.1 1.3e-43 149.5 9.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG83718.1 - 9.3e-12 44.5 37.8 6.4e-11 41.8 34.8 3.1 2 1 1 3 3 3 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG83718.1 - 2.3e-05 23.1 1.4 2.3e-05 23.1 1.4 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF4383 PF14325.6 CRG83718.1 - 0.044 14.1 8.0 0.41 10.9 8.0 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4383) DUF2961 PF11175.8 CRG83719.1 - 7.2e-87 290.9 3.9 9.1e-87 290.6 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2961) Fungal_trans PF04082.18 CRG83720.1 - 9.8e-05 21.5 0.4 0.00013 21.1 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4937 PF16291.5 CRG83721.1 - 0.14 12.4 0.3 0.26 11.6 0.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4937 DUF202 PF02656.15 CRG83721.1 - 0.41 11.1 3.4 0.43 11.1 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF202) RNA_pol_Rpc4 PF05132.14 CRG83722.1 - 2.5e-31 109.1 0.0 2.5e-31 109.1 0.0 3.8 2 1 2 4 4 4 1 RNA polymerase III RPC4 Zn_clus PF00172.18 CRG83723.1 - 0.0018 18.4 12.2 0.0037 17.4 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 CRG83723.1 - 1.2 8.7 4.3 0.53 9.8 0.1 2.3 2 0 0 2 2 2 0 Histone chaperone domain CHZ Cyclin_N PF00134.23 CRG83724.1 - 3.7e-44 149.5 0.6 8.4e-44 148.4 0.4 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CRG83724.1 - 6.2e-32 110.2 0.1 1.3e-31 109.1 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain HA2 PF04408.23 CRG83725.1 - 5.8e-18 65.1 0.3 7.4e-17 61.6 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CRG83725.1 - 6.1e-15 55.4 0.0 1.2e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CRG83725.1 - 1.2e-13 51.3 0.0 2.8e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG83725.1 - 1.1e-10 41.5 0.2 2e-10 40.7 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.22 CRG83725.1 - 1.4e-10 41.5 0.0 3.5e-10 40.2 0.0 1.8 1 0 0 1 1 1 1 RWD domain DND1_DSRM PF14709.7 CRG83725.1 - 0.00052 20.2 0.0 0.0015 18.7 0.0 1.9 1 0 0 1 1 1 1 double strand RNA binding domain from DEAD END PROTEIN 1 PhoH PF02562.16 CRG83725.1 - 0.0043 16.5 0.0 0.0077 15.7 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein T2SSE PF00437.20 CRG83725.1 - 0.0043 16.1 0.0 0.0089 15.1 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CRG83725.1 - 0.0049 17.1 3.0 0.026 14.8 2.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CRG83725.1 - 0.028 14.2 0.4 0.18 11.5 0.0 2.4 3 0 0 3 3 3 0 AAA domain ATPase PF06745.13 CRG83725.1 - 0.039 13.3 0.0 0.076 12.3 0.0 1.4 1 0 0 1 1 1 0 KaiC IstB_IS21 PF01695.17 CRG83725.1 - 0.051 13.3 0.0 4.7 6.9 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein dsRBD2 PF17842.1 CRG83725.1 - 0.074 13.3 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 AAA_23 PF13476.6 CRG83725.1 - 0.074 13.5 1.0 0.6 10.6 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CRG83725.1 - 0.097 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-C2HE PF16278.5 CRG83726.1 - 2.1e-18 66.5 0.2 2.1e-18 66.5 0.2 2.0 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 CRG83726.1 - 3e-16 59.9 3.2 5.4e-15 55.9 3.2 2.2 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 CRG83726.1 - 1.8e-13 51.0 1.3 5.9e-13 49.4 0.6 2.1 2 1 0 2 2 2 1 HIT domain TRAP_alpha PF03896.16 CRG83727.1 - 3.9e-08 32.9 1.1 6.4e-08 32.1 1.1 1.3 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF1129 PF06570.11 CRG83727.1 - 0.11 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) zf-CCCH_4 PF18044.1 CRG83728.1 - 1.2 9.0 12.5 0.33 10.8 0.6 2.9 3 0 0 3 3 3 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CRG83728.1 - 5.8 7.1 12.1 3.2 7.9 0.6 4.0 4 0 0 4 4 4 0 Zinc finger domain POT1PC PF16686.5 CRG83729.1 - 2.3e-42 144.5 4.3 3.3e-41 140.7 1.4 2.4 2 0 0 2 2 2 2 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 CRG83729.1 - 4.4e-24 84.9 0.0 1.9e-23 82.9 0.0 2.0 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 Allexi_40kDa PF05549.11 CRG83729.1 - 0.13 11.7 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein Arm PF00514.23 CRG83730.1 - 8.7e-95 308.2 13.6 4.1e-14 52.0 0.0 8.2 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 CRG83730.1 - 6e-27 93.9 1.1 6e-27 93.9 1.1 1.8 2 0 0 2 2 1 1 Importin beta binding domain Arm_3 PF16186.5 CRG83730.1 - 1.2e-23 82.4 4.1 2.3e-23 81.5 4.1 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 CRG83730.1 - 1.5e-21 76.5 5.1 1.5e-09 38.2 0.1 6.1 3 2 3 6 6 6 4 HEAT-like repeat HEAT_2 PF13646.6 CRG83730.1 - 3.6e-20 72.1 0.1 4e-09 36.7 0.1 5.2 1 1 3 5 5 5 3 HEAT repeats HEAT PF02985.22 CRG83730.1 - 1.1e-18 65.7 0.2 3.5e-06 26.8 0.0 6.7 7 0 0 7 7 7 4 HEAT repeat Arm_2 PF04826.13 CRG83730.1 - 2.4e-09 37.1 0.0 0.001 18.6 0.0 3.9 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 CRG83730.1 - 1.5e-05 25.1 0.0 0.79 9.9 0.0 4.1 4 1 0 4 4 4 1 V-ATPase subunit H Adaptin_N PF01602.20 CRG83730.1 - 1.7e-05 23.6 0.0 0.0013 17.4 0.0 2.3 2 0 0 2 2 2 1 Adaptin N terminal region HEAT_PBS PF03130.16 CRG83730.1 - 0.00035 21.0 0.7 0.78 10.6 0.1 4.5 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Cnd1 PF12717.7 CRG83730.1 - 0.00036 20.6 0.0 0.6 10.1 0.0 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Mo25 PF08569.11 CRG83730.1 - 0.013 14.9 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Mo25-like RICTOR_V PF14668.6 CRG83730.1 - 0.038 14.2 3.4 1.1 9.6 0.0 4.4 4 2 1 5 5 5 0 Rapamycin-insensitive companion of mTOR, domain 5 NUSAP PF16006.5 CRG83730.1 - 3.2 7.4 6.6 4.8 6.9 6.6 1.2 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein STAG PF08514.11 CRG83731.1 - 4.2e-31 107.2 0.1 4.2e-31 107.2 0.1 2.3 2 0 0 2 2 2 1 STAG domain YL1 PF05764.13 CRG83731.1 - 0.00019 21.6 17.7 0.00019 21.6 17.7 5.0 4 1 1 5 5 5 1 YL1 nuclear protein HEAT PF02985.22 CRG83731.1 - 0.00025 21.0 0.0 8.9 6.9 0.1 5.6 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 CRG83731.1 - 0.0016 18.7 5.6 0.1 13.0 0.1 4.7 6 0 0 6 6 6 1 HEAT repeats BLOC1_2 PF10046.9 CRG83731.1 - 1.7 9.0 7.1 14 6.1 0.2 3.5 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 UreD PF01774.17 CRG83732.1 - 3.2e-78 262.5 0.0 3.7e-78 262.3 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein Methyltransf_11 PF08241.12 CRG83735.1 - 1.3e-11 45.0 0.0 2.7e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG83735.1 - 3.2e-11 43.4 0.0 4.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG83735.1 - 2e-09 38.0 0.0 3.7e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83735.1 - 4.8e-08 33.6 0.0 1e-07 32.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG83735.1 - 2.5e-06 27.3 0.0 4.3e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG83735.1 - 0.002 17.5 0.0 0.0027 17.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 CRG83735.1 - 0.0057 15.9 0.0 0.008 15.4 0.0 1.2 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family S1 PF00575.23 CRG83736.1 - 4.9e-74 244.7 25.2 5.5e-13 49.1 0.8 12.0 12 0 0 12 12 12 10 S1 RNA binding domain TPR_19 PF14559.6 CRG83736.1 - 3e-07 30.8 0.1 0.12 12.9 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG83736.1 - 0.00015 22.3 2.5 24 6.1 0.1 5.7 5 2 2 7 7 7 1 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 CRG83736.1 - 0.00016 21.5 0.4 0.85 9.6 0.0 4.1 5 0 0 5 5 5 2 RNase II-type exonuclease C-terminal S1 domain Suf PF05843.14 CRG83736.1 - 0.0013 18.8 10.3 0.31 11.0 1.0 4.3 2 1 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_16 PF13432.6 CRG83736.1 - 0.012 16.2 0.1 6.8 7.4 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 CRG83736.1 - 0.037 14.3 0.0 7.4 7.1 0.0 3.2 2 0 0 2 2 2 0 PPR repeat WD40 PF00400.32 CRG83737.1 - 6e-15 55.4 8.5 3.3e-05 24.5 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG83737.1 - 3.1e-06 27.4 0.1 0.0017 18.6 0.0 4.3 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CRG83737.1 - 0.022 13.3 0.0 0.034 12.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain WD40_like PF17005.5 CRG83737.1 - 0.1 11.9 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain Cpn60_TCP1 PF00118.24 CRG83738.1 - 1.6e-150 502.0 17.8 1.9e-150 501.8 17.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Dehyd-heme_bind PF09098.10 CRG83738.1 - 0.077 12.6 0.1 0.36 10.4 0.0 2.1 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding ProRS-C_1 PF09180.11 CRG83739.1 - 1.8e-23 82.5 0.2 6.3e-23 80.8 0.3 1.9 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 CRG83739.1 - 6.3e-18 65.4 0.0 9.7e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CRG83739.1 - 2.8e-12 46.6 0.0 6.6e-12 45.4 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain RNase_PH PF01138.21 CRG83741.1 - 6.4e-31 107.6 0.2 2.8e-30 105.5 0.0 2.1 3 0 0 3 3 3 1 3' exoribonuclease family, domain 1 PEMT PF04191.13 CRG83742.1 - 8.4e-61 203.0 7.3 4.9e-37 126.5 0.6 2.5 2 0 0 2 2 2 2 Phospholipid methyltransferase HECW_N PF16562.5 CRG83742.1 - 0.021 14.6 0.0 0.058 13.2 0.0 1.7 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 SKICH PF17751.1 CRG83742.1 - 0.088 13.4 0.1 2.4 8.7 0.0 2.4 2 0 0 2 2 2 0 SKICH domain MRJP PF03022.16 CRG83743.1 - 8.1e-11 41.8 0.0 1.2e-10 41.3 0.0 1.2 1 0 0 1 1 1 1 Major royal jelly protein SGL PF08450.12 CRG83743.1 - 9.3e-05 22.1 0.7 0.5 9.9 0.0 3.0 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region FAD_binding_4 PF01565.23 CRG83744.1 - 3.4e-15 56.0 0.1 5.1e-15 55.4 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain ALO PF04030.14 CRG83744.1 - 1e-08 35.4 0.5 1.6e-08 34.7 0.5 1.3 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase ParA PF10609.9 CRG83745.1 - 7.4e-94 313.8 0.0 8.7e-94 313.6 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CRG83745.1 - 5e-10 39.5 0.0 8.1e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 CRG83745.1 - 2.3e-07 30.3 0.4 2.5e-05 23.6 0.1 2.7 1 1 0 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 CRG83745.1 - 1.2e-06 28.5 0.0 1.3e-05 25.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_26 PF13500.6 CRG83745.1 - 0.00011 22.2 0.0 0.042 13.7 0.0 2.1 2 0 0 2 2 2 2 AAA domain Fer4_NifH PF00142.18 CRG83745.1 - 0.00016 21.2 0.0 0.4 10.1 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family CLP1_P PF16575.5 CRG83745.1 - 0.013 15.3 0.0 0.031 14.1 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RsgA_GTPase PF03193.16 CRG83745.1 - 0.015 15.2 0.1 0.037 13.9 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_25 PF13481.6 CRG83745.1 - 0.04 13.5 0.1 0.081 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 CRG83745.1 - 0.075 12.3 0.0 0.24 10.7 0.0 1.7 1 1 0 1 1 1 0 ATPase MipZ AAA_16 PF13191.6 CRG83745.1 - 0.091 13.1 0.0 0.17 12.2 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain KAP_NTPase PF07693.14 CRG83745.1 - 0.092 12.0 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain RNA_helicase PF00910.22 CRG83745.1 - 0.097 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 CRG83745.1 - 0.13 12.2 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) CBP_BcsQ PF06564.12 CRG83745.1 - 0.15 11.5 0.0 2.1 7.8 0.0 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ TsaE PF02367.17 CRG83745.1 - 0.16 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 CRG83745.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain NB-ARC PF00931.22 CRG83745.1 - 0.18 11.0 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 CRG83745.1 - 0.23 10.7 0.0 0.38 10.0 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 CRG83745.1 - 0.24 11.1 0.0 0.66 9.7 0.0 1.6 2 0 0 2 2 2 0 IstB-like ATP binding protein Asp PF00026.23 CRG83746.1 - 2.1e-64 217.9 13.4 3e-64 217.4 13.4 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG83746.1 - 3.7e-10 40.3 4.4 0.00011 22.5 0.8 3.4 2 2 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG83746.1 - 9.2e-07 29.4 5.9 0.0095 16.6 0.6 3.3 3 2 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 CRG83746.1 - 0.1 13.1 5.9 4 8.1 0.5 3.5 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease tRNA_bind PF01588.20 CRG83747.1 - 2.2e-21 75.8 0.1 2.7e-20 72.3 0.1 2.4 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 CRG83747.1 - 9.1e-07 28.8 0.0 1.8e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG83747.1 - 0.0028 17.8 0.0 0.0028 17.8 0.0 3.1 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG83747.1 - 0.3 11.3 0.0 0.3 11.3 0.0 2.3 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain Vfa1 PF08432.10 CRG83747.1 - 0.64 10.3 9.0 1.1 9.6 9.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Anp1 PF03452.14 CRG83748.1 - 3.6e-112 374.1 0.0 3.6e-112 374.1 0.0 1.9 2 0 0 2 2 2 1 Anp1 Smg8_Smg9 PF10220.9 CRG83748.1 - 2.3 6.4 14.1 3.4 5.9 14.1 1.2 1 0 0 1 1 1 0 Smg8_Smg9 Hid1 PF12722.7 CRG83748.1 - 8.6 4.3 16.1 13 3.8 16.1 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dcc1 PF09724.9 CRG83749.1 - 2.1e-28 99.6 0.0 2.5e-28 99.4 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Acetyltransf_9 PF13527.7 CRG83750.1 - 1.5e-05 25.1 0.0 3.2e-05 24.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG83750.1 - 0.00015 22.2 0.0 0.00033 21.0 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG83750.1 - 0.0097 15.8 0.0 0.021 14.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG83750.1 - 0.038 14.0 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_1 PF00583.25 CRG83750.1 - 0.043 14.0 0.0 0.088 13.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DUF5490 PF17593.2 CRG83750.1 - 0.062 13.3 0.4 0.14 12.2 0.4 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5490) IBR PF01485.21 CRG83751.1 - 0.00021 21.4 4.3 0.00021 21.4 4.3 3.6 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain DUF1936 PF09151.10 CRG83751.1 - 0.52 10.3 7.1 1.2 9.1 0.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1936) Methyltransf_23 PF13489.6 CRG83752.1 - 1.1e-18 67.6 0.0 2.4e-18 66.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83752.1 - 6.2e-09 36.4 0.0 2.5e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG83752.1 - 2.3e-06 28.3 0.2 2.2e-05 25.1 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83752.1 - 1.4e-05 25.7 0.0 3.8e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG83752.1 - 3.4e-05 23.7 0.0 0.00066 19.5 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain RNA_pol_3_Rpc31 PF11705.8 CRG83752.1 - 1.6 8.9 13.7 4.2 7.6 13.7 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Selenoprotein_S PF06936.11 CRG83752.1 - 5.6 6.7 13.6 11 5.8 13.6 1.4 1 0 0 1 1 1 0 Selenoprotein S (SelS) IBN_N PF03810.19 CRG83753.1 - 2.1e-07 30.7 1.5 5.8e-05 22.9 0.0 4.6 4 1 0 4 4 4 1 Importin-beta N-terminal domain RIX1 PF08167.12 CRG83753.1 - 0.00053 19.8 0.7 0.0063 16.3 0.0 3.0 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis Xpo1 PF08389.12 CRG83753.1 - 0.0011 19.1 0.0 0.027 14.5 0.0 3.3 2 0 0 2 2 2 1 Exportin 1-like protein CAS_CSE1 PF03378.15 CRG83753.1 - 0.013 14.0 0.0 0.035 12.6 0.0 1.6 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus RICTOR_N PF14664.6 CRG83753.1 - 0.028 13.4 0.0 0.079 11.9 0.0 1.7 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term TAF6_C PF07571.13 CRG83753.1 - 0.12 12.7 0.0 0.83 10.0 0.0 2.5 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain DUF4611 PF15387.6 CRG83753.1 - 0.12 12.6 0.2 0.32 11.3 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) GNAT_like PF18407.1 CRG83753.1 - 1.1 9.7 5.3 0.65 10.4 0.6 3.0 3 0 0 3 3 3 0 GCN5-related N-acetyltransferase like domain HEAT PF02985.22 CRG83753.1 - 1.8 9.1 5.7 31 5.2 0.0 4.6 4 0 0 4 4 4 0 HEAT repeat Phasin_2 PF09361.10 CRG83753.1 - 3.1 8.1 7.1 2.5 8.4 0.2 3.9 3 1 1 4 4 4 0 Phasin protein HORMA PF02301.18 CRG83754.1 - 6.7e-09 35.6 0.0 8.7e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 HORMA domain Cas_Csm6 PF09659.10 CRG83754.1 - 0.031 13.1 0.0 0.039 12.7 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) MDMPI_N PF11716.8 CRG83754.1 - 0.084 13.6 0.0 0.17 12.6 0.0 1.4 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Zn_clus PF00172.18 CRG83755.1 - 1.4e-07 31.5 11.8 2.3e-07 30.8 11.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2576 PF10845.8 CRG83755.1 - 0.0012 18.4 2.1 0.044 13.4 0.2 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2576) Uds1 PF15456.6 CRG83755.1 - 2 8.6 4.9 1.5 9.0 0.3 2.4 2 0 0 2 2 2 0 Up-regulated During Septation PhyH PF05721.13 CRG83756.1 - 8.9e-10 39.2 0.0 2.7e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Het-C PF07217.11 CRG83757.1 - 4.9e-279 926.6 0.0 6.7e-279 926.2 0.0 1.1 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C SUIM_assoc PF16619.5 CRG83757.1 - 0.59 10.2 5.2 1.3 9.2 0.7 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 CS PF04969.16 CRG83758.1 - 4.2e-06 27.7 0.1 7.4e-06 26.9 0.1 1.5 1 1 0 1 1 1 1 CS domain Snf7 PF03357.21 CRG83759.1 - 1.1e-19 70.7 17.1 1.1e-19 70.6 14.6 1.8 1 1 1 2 2 2 1 Snf7 Gon7 PF08738.10 CRG83759.1 - 0.015 15.4 5.5 0.038 14.1 3.0 2.2 2 0 0 2 2 2 0 Gon7 family PSD4 PF07631.11 CRG83759.1 - 0.064 13.8 1.4 1.6 9.3 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1592) DUF3459 PF11941.8 CRG83759.1 - 0.086 13.2 0.4 0.52 10.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3459) DUF2408 PF10303.9 CRG83759.1 - 1 9.9 9.2 0.55 10.8 6.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Fib_alpha PF08702.10 CRG83759.1 - 1.8 8.7 13.4 2.2 8.5 8.0 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.6 CRG83759.1 - 2.2 7.6 14.4 0.23 10.8 4.8 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 CRG83759.1 - 3.9 7.6 17.7 0.11 12.5 7.3 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 CRG83759.1 - 8.1 4.9 12.3 12 4.3 12.3 1.3 1 1 0 1 1 1 0 AAA domain RRM_1 PF00076.22 CRG83760.1 - 2.1e-14 53.1 0.0 3.5e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 CRG83760.1 - 7.4e-08 32.8 1.1 7.4e-08 32.8 1.1 2.6 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 CRG83760.1 - 0.00071 19.4 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif HD PF01966.22 CRG83760.1 - 0.011 15.9 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 0 HD domain ketoacyl-synt PF00109.26 CRG83761.1 - 1.2e-64 218.3 0.1 1.6e-63 214.6 0.0 2.4 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG83761.1 - 1e-57 195.0 0.0 2.8e-57 193.5 0.0 1.8 2 0 0 2 2 1 1 KR domain PS-DH PF14765.6 CRG83761.1 - 3.1e-49 167.8 0.0 6.6e-49 166.7 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG83761.1 - 8.6e-49 166.8 0.0 2.1e-48 165.5 0.0 1.7 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG83761.1 - 2.7e-36 124.1 0.0 4.7e-35 120.2 0.0 2.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG83761.1 - 7.5e-17 61.9 0.0 1.8e-16 60.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG83761.1 - 9.3e-16 58.3 0.0 2.7e-15 56.8 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 CRG83761.1 - 1.1e-11 44.9 0.0 2.3e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83761.1 - 2.9e-10 40.7 0.0 1e-09 38.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CRG83761.1 - 5.4e-10 39.0 0.0 1.3e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CRG83761.1 - 1.5e-08 34.6 0.0 3.4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CRG83761.1 - 2e-08 35.4 0.0 1.7e-07 32.3 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_11 PF08241.12 CRG83761.1 - 3.7e-08 33.9 0.0 1.4e-07 32.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CRG83761.1 - 3.8e-08 33.4 0.0 2.5e-07 30.7 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CRG83761.1 - 6.2e-06 25.9 0.0 1.2e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_16 PF10294.9 CRG83761.1 - 0.00015 21.6 0.0 0.00036 20.3 0.0 1.6 1 0 0 1 1 1 1 Lysine methyltransferase PP-binding PF00550.25 CRG83761.1 - 0.00017 21.9 0.0 0.00044 20.6 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.18 CRG83761.1 - 0.0015 17.9 0.0 0.0052 16.2 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 CRG83761.1 - 0.0017 18.3 0.2 0.0051 16.7 0.2 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF938 PF06080.12 CRG83761.1 - 0.0023 17.7 0.0 0.0066 16.2 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF938) NodS PF05401.11 CRG83761.1 - 0.006 16.2 0.0 0.019 14.6 0.0 1.9 1 0 0 1 1 1 1 Nodulation protein S (NodS) DREV PF05219.12 CRG83761.1 - 0.008 15.3 0.0 0.017 14.2 0.0 1.4 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_28 PF02636.17 CRG83761.1 - 0.11 12.1 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 CRG83761.1 - 0.16 11.0 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Thiolase_N PF00108.23 CRG83761.1 - 0.17 11.2 0.4 0.37 10.1 0.1 1.6 2 0 0 2 2 2 0 Thiolase, N-terminal domain FSH1 PF03959.13 CRG83762.1 - 4.2e-24 85.4 0.0 5.7e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 CRG83762.1 - 0.04 13.6 0.0 0.055 13.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Herpes_US9 PF06072.11 CRG83763.1 - 6.3 6.8 6.1 21 5.1 0.1 2.8 2 1 0 2 2 2 0 Alphaherpesvirus tegument protein US9 NAD_binding_4 PF07993.12 CRG83764.1 - 6e-32 110.8 0.0 8.6e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG83764.1 - 4.4e-26 91.4 0.0 6.6e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CRG83764.1 - 6.8e-11 42.1 0.0 2.1e-10 40.5 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG83764.1 - 8.5e-08 32.4 0.0 2.1e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 CRG83764.1 - 0.0067 15.5 0.0 0.025 13.6 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Unstab_antitox PF09720.10 CRG83764.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.1 2 0 0 2 2 2 0 Putative addiction module component KR PF08659.10 CRG83764.1 - 0.082 12.8 0.1 0.51 10.2 0.1 2.1 1 1 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 CRG83764.1 - 0.17 11.2 0.0 0.47 9.8 0.0 1.7 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fungal_trans_2 PF11951.8 CRG83765.1 - 3.4e-15 55.7 5.1 4.8e-15 55.2 5.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 CRG83766.1 - 6.7e-105 351.6 16.4 7.6e-105 351.4 16.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83766.1 - 3.7e-23 82.0 51.7 1.6e-19 70.1 24.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG83766.1 - 0.064 11.5 3.5 0.13 10.5 3.5 1.5 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family adh_short_C2 PF13561.6 CRG83767.1 - 9.9e-52 175.8 0.3 1.3e-51 175.4 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83767.1 - 1.1e-40 139.2 0.6 1.3e-40 138.9 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG83767.1 - 1.1e-12 48.2 1.0 1.6e-12 47.7 1.0 1.2 1 0 0 1 1 1 1 KR domain AIRC PF00731.20 CRG83767.1 - 0.015 14.9 0.1 0.085 12.4 0.0 2.0 2 0 0 2 2 2 0 AIR carboxylase Epimerase PF01370.21 CRG83767.1 - 0.041 13.3 0.4 0.17 11.3 0.4 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Transketolase_N PF00456.21 CRG83768.1 - 2.7e-128 427.6 0.0 4.5e-128 426.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CRG83768.1 - 2e-37 128.6 0.0 3.9e-37 127.7 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain DXP_synthase_N PF13292.6 CRG83768.1 - 5.7e-07 29.0 0.0 1.2e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Transketolase_C PF02780.20 CRG83768.1 - 1.6e-06 28.0 0.0 3.1e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain E1_dh PF00676.20 CRG83768.1 - 2.6e-05 23.3 0.1 3.9e-05 22.8 0.1 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component Toxin_ToxA PF11584.8 CRG83768.1 - 0.036 14.1 0.3 0.072 13.1 0.3 1.5 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA PepSY_2 PF13670.6 CRG83768.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF3405 PF11885.8 CRG83769.1 - 1.2e-169 565.3 0.2 1.5e-169 565.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Thr_synth_N PF14821.6 CRG83770.1 - 8.9e-26 89.9 0.0 2.7e-25 88.4 0.0 1.9 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 CRG83770.1 - 1.5e-17 64.0 0.0 1.8e-14 53.9 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme WYL_3 PF18488.1 CRG83770.1 - 0.0012 19.2 0.0 2.8 8.4 0.0 2.4 2 0 0 2 2 2 2 WYL domain GMC_oxred_N PF00732.19 CRG83771.1 - 8.5e-62 209.2 0.0 1.1e-61 208.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG83771.1 - 1.4e-33 116.4 0.0 2.3e-33 115.7 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CRG83771.1 - 1e-05 24.8 0.1 2.1e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CRG83771.1 - 1.2e-05 25.4 0.6 2.8e-05 24.3 0.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG83771.1 - 2.7e-05 23.5 0.9 0.0065 15.6 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CRG83771.1 - 0.00015 21.5 6.1 0.00092 18.9 4.9 2.6 1 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG83771.1 - 0.00095 18.5 0.5 0.69 9.1 0.1 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox_2 PF07992.14 CRG83771.1 - 0.012 14.9 0.1 0.08 12.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Beta-lactamase PF00144.24 CRG83773.1 - 1.8e-50 172.1 0.0 2.3e-50 171.7 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 CRG83773.1 - 0.16 11.5 0.0 0.44 10.1 0.0 1.6 2 0 0 2 2 2 0 Beta-lactamase enzyme family Peptidase_S11 PF00768.20 CRG83773.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Glyco_hydro_16 PF00722.21 CRG83774.1 - 5.2e-16 58.6 0.1 5.3e-16 58.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 PRIMA1 PF16101.5 CRG83775.1 - 0.18 11.9 5.1 0.39 10.8 5.1 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-HIT PF04438.16 CRG83776.1 - 1.5e-10 40.7 8.9 2.4e-10 40.1 8.9 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-MYND PF01753.18 CRG83776.1 - 0.44 10.7 8.2 0.9 9.7 8.2 1.5 1 0 0 1 1 1 0 MYND finger DUF3294 PF07957.11 CRG83777.1 - 0.0031 17.3 0.0 0.0052 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) LPP PF04728.13 CRG83777.1 - 0.0086 16.4 0.5 0.12 12.7 0.1 2.7 2 1 1 3 3 3 2 Lipoprotein leucine-zipper Cluap1 PF10234.9 CRG83777.1 - 0.011 15.2 0.6 0.019 14.4 0.6 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF1664 PF07889.12 CRG83777.1 - 0.015 15.4 0.2 0.13 12.3 0.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4686 PF15742.5 CRG83777.1 - 0.032 13.4 0.3 0.051 12.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) Spc7 PF08317.11 CRG83777.1 - 0.035 13.0 0.1 0.057 12.3 0.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1640 PF07798.11 CRG83777.1 - 0.041 13.9 0.8 0.087 12.9 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) CENP-F_leu_zip PF10473.9 CRG83777.1 - 0.075 13.1 0.3 0.17 11.9 0.3 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JIP_LZII PF16471.5 CRG83777.1 - 0.23 11.7 0.7 7.4 6.8 0.0 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Glyco_hydro_16 PF00722.21 CRG83778.1 - 0.033 13.6 0.1 0.052 13.0 0.1 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 16 Peptidase_C48 PF02902.19 CRG83779.1 - 3.1e-25 89.3 0.0 5.6e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain PAP2 PF01569.21 CRG83780.1 - 3e-18 65.9 2.9 1e-17 64.2 2.9 1.9 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 CRG83780.1 - 0.00059 19.6 2.6 0.0015 18.2 2.6 1.8 1 0 0 1 1 1 1 PAP2 superfamily TMEM213 PF15192.6 CRG83780.1 - 0.15 12.0 0.5 0.42 10.6 0.5 1.7 1 0 0 1 1 1 0 TMEM213 family Ras PF00071.22 CRG83781.1 - 4.5e-48 162.9 0.0 6.3e-48 162.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG83781.1 - 8.1e-21 74.5 0.0 1.3e-20 73.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG83781.1 - 6.6e-05 22.4 0.0 0.00013 21.4 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 CRG83781.1 - 0.05 13.1 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 CRG83781.1 - 0.1 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DASH_Dad1 PF08649.10 CRG83782.1 - 2.6e-24 85.2 5.5 3.2e-24 84.9 5.5 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 V_ATPase_I PF01496.19 CRG83782.1 - 0.099 10.5 0.3 0.1 10.5 0.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fungal_trans_2 PF11951.8 CRG83783.1 - 7.1e-39 133.7 0.9 2.2e-38 132.1 0.9 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG83783.1 - 2e-31 109.2 48.9 5e-28 98.1 45.9 3.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83783.1 - 1.3e-10 40.7 27.6 4.7e-07 29.0 8.1 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter Zn_clus PF00172.18 CRG83783.1 - 5.1e-09 36.1 10.8 8.4e-09 35.4 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_6 PF12697.7 CRG83784.1 - 2.9e-09 37.8 1.5 2.9e-09 37.8 1.5 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family Zn_clus PF00172.18 CRG83784.1 - 4.2e-08 33.2 11.5 7.7e-08 32.3 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG83784.1 - 0.00047 19.1 0.1 0.00047 19.1 0.1 1.8 3 0 0 3 3 3 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG83785.1 - 9.5e-26 90.5 0.2 1.3e-25 90.0 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83785.1 - 7.4e-24 84.6 0.2 1.1e-23 84.1 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83785.1 - 1.6e-08 34.7 0.5 3.2e-08 33.7 0.1 1.6 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 CRG83785.1 - 3.7e-08 33.5 0.9 7.4e-08 32.5 0.9 1.5 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG83785.1 - 7.3e-06 25.7 0.1 1.4e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 CRG83785.1 - 0.00022 21.5 0.4 0.00059 20.1 0.0 1.9 2 1 0 2 2 2 1 TrkA-N domain Epimerase PF01370.21 CRG83785.1 - 0.00071 19.1 0.0 0.027 13.9 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG83785.1 - 0.12 11.3 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Zn_clus PF00172.18 CRG83786.1 - 5.4e-05 23.2 7.1 0.0001 22.4 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-PHD-like PF15446.6 CRG83786.1 - 0.27 10.8 4.4 0.61 9.7 4.4 1.5 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain DUF2457 PF10446.9 CRG83787.1 - 0.013 14.6 4.2 0.015 14.5 4.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Haem_degrading PF03928.14 CRG83787.1 - 0.14 12.2 0.0 0.17 11.9 0.0 1.0 1 0 0 1 1 1 0 Haem-degrading DUF3435 PF11917.8 CRG83788.1 - 1.5e-12 47.2 0.0 1.6e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) APH PF01636.23 CRG83789.1 - 5.9e-13 49.3 0.1 1.4e-12 48.0 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG83789.1 - 5e-09 36.1 0.0 5.6e-08 32.6 0.0 2.1 1 1 0 1 1 1 1 Choline/ethanolamine kinase FAD_binding_3 PF01494.19 CRG83791.1 - 2e-71 241.1 0.0 2.6e-71 240.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DUF866 PF05907.13 CRG83791.1 - 4.6e-57 192.3 0.2 9.7e-57 191.2 0.2 1.5 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Phe_hydrox_dim PF07976.12 CRG83791.1 - 7.7e-38 130.1 0.0 1.3e-37 129.4 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain LSM PF01423.22 CRG83791.1 - 8.7e-17 60.6 0.0 1.6e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 LSM domain DAO PF01266.24 CRG83791.1 - 0.0041 16.8 0.0 0.053 13.1 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG83791.1 - 0.032 13.5 0.0 0.066 12.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HalOD2 PF18547.1 CRG83791.1 - 0.076 12.9 0.3 0.27 11.1 0.3 2.0 1 0 0 1 1 1 0 Halobacterial output domain 2 NAD_binding_8 PF13450.6 CRG83791.1 - 0.089 13.0 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG83791.1 - 0.1 13.2 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF4379 PF14311.6 CRG83791.1 - 0.17 12.3 0.2 0.54 10.7 0.2 1.9 1 0 0 1 1 1 0 Probable Zinc-ribbon domain ApbA PF02558.16 CRG83791.1 - 0.18 11.5 0.0 0.41 10.3 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DDHD PF02862.17 CRG83793.1 - 1.6e-27 97.1 1.0 5.3e-25 88.9 0.0 3.3 3 1 0 3 3 3 1 DDHD domain Abhydrolase_6 PF12697.7 CRG83793.1 - 0.02 15.5 0.1 0.069 13.7 0.0 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family MoCF_biosynth PF00994.24 CRG83794.1 - 8.4e-50 168.2 0.0 1.4e-25 89.6 0.0 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 CRG83794.1 - 1.9e-40 138.2 2.9 2.9e-40 137.6 2.9 1.3 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) ATP-synt_C PF00137.21 CRG83794.1 - 4.4e-23 81.4 28.0 3e-13 49.9 12.9 3.0 2 0 0 2 2 2 2 ATP synthase subunit C MoeA_C PF03454.15 CRG83794.1 - 1.7e-16 60.2 0.1 4.4e-16 58.8 0.1 1.8 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) SLATT_5 PF18160.1 CRG83794.1 - 0.42 9.9 3.9 0.17 11.2 0.8 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Ras PF00071.22 CRG83795.1 - 2.1e-59 199.8 0.2 2.7e-59 199.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG83795.1 - 5.8e-37 126.6 0.1 1e-36 125.8 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG83795.1 - 1.8e-17 63.4 0.2 2.2e-17 63.1 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG83795.1 - 6.1e-06 25.9 0.1 3.9e-05 23.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CRG83795.1 - 8.2e-06 25.4 0.0 1.3e-05 24.7 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CRG83795.1 - 1.8e-05 24.8 0.0 2.8e-05 24.1 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CRG83795.1 - 5.9e-05 22.5 0.2 7.4e-05 22.2 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CRG83795.1 - 8.4e-05 22.5 0.1 0.085 12.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase TIR_2 PF13676.6 CRG83795.1 - 0.081 13.5 0.0 0.14 12.8 0.0 1.5 1 0 0 1 1 1 0 TIR domain AAA_7 PF12775.7 CRG83795.1 - 0.093 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region NAD_binding_10 PF13460.6 CRG83796.1 - 4.2e-08 33.3 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CRG83796.1 - 0.0013 17.9 0.0 0.032 13.3 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CRG83796.1 - 0.0027 16.9 0.0 0.012 14.8 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein Epimerase PF01370.21 CRG83796.1 - 0.0037 16.7 0.0 0.0054 16.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG83796.1 - 0.042 12.8 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 CRG83796.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Kei1 PF08552.11 CRG83797.1 - 1.1e-66 224.4 1.5 1.5e-66 224.0 1.5 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 NIR_SIR PF01077.22 CRG83798.1 - 2e-50 170.4 0.0 7.6e-45 152.3 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 CRG83798.1 - 6.6e-31 106.0 0.0 1.6e-14 53.5 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 CRG83798.1 - 3.4e-26 92.2 0.0 6.5e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 CRG83798.1 - 4.5e-06 26.6 0.1 8.9e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Sin_N PF04801.13 CRG83799.1 - 1.7e-25 90.1 0.0 2.7e-25 89.5 0.0 1.3 1 1 0 1 1 1 1 Sin-like protein conserved region Flavoprotein PF02441.19 CRG83800.1 - 1.7e-43 148.1 0.0 2.2e-43 147.8 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein RNA_pol PF00940.19 CRG83801.1 - 1.6e-178 593.8 0.0 2.3e-178 593.3 0.0 1.2 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 CRG83801.1 - 2.3e-78 264.0 0.0 4.5e-78 263.0 0.0 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal HAGH_C PF16123.5 CRG83801.1 - 0.091 13.3 0.2 1.2 9.7 0.1 2.9 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus PRP21_like_P PF12230.8 CRG83801.1 - 1.2 9.0 5.2 0.44 10.4 0.5 2.2 2 0 0 2 2 2 0 Pre-mRNA splicing factor PRP21 like protein Fungal_trans PF04082.18 CRG83802.1 - 4.4e-33 114.5 0.0 7.9e-33 113.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83802.1 - 7.4e-09 35.6 9.6 1.3e-08 34.8 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Recep_L_domain PF01030.24 CRG83803.1 - 0.0019 18.3 0.1 3.3 7.9 0.0 3.4 2 2 0 2 2 2 2 Receptor L domain Radical_SAM PF04055.21 CRG83804.1 - 8.2e-09 36.1 0.0 1.2e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 CRG83804.1 - 0.00019 21.7 0.0 0.00035 20.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 CRG83804.1 - 0.04 14.1 0.1 0.14 12.3 0.1 1.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain Methyltransf_33 PF10017.9 CRG83805.1 - 1.9e-83 280.1 0.1 2.8e-83 279.6 0.1 1.2 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 CRG83805.1 - 2.8e-24 86.1 4.2 5e-24 85.3 4.2 1.5 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Fungal_trans_2 PF11951.8 CRG83806.1 - 2.3e-17 62.9 3.3 1.3e-15 57.1 3.3 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain GST_N_3 PF13417.6 CRG83807.1 - 6.5e-16 58.5 0.0 1.4e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG83807.1 - 1.4e-15 57.4 0.0 2.3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG83807.1 - 1.1e-12 48.0 0.1 1.6e-12 47.5 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG83807.1 - 2.3e-11 43.8 0.0 6e-11 42.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG83807.1 - 6.1e-05 23.1 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG83807.1 - 9.7e-05 22.3 0.1 0.00017 21.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG83807.1 - 0.019 15.7 0.0 0.04 14.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 CRG83807.1 - 0.1 12.4 0.0 0.32 10.8 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Herpes_UL14 PF03580.14 CRG83808.1 - 0.02 15.2 0.0 0.024 14.9 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL14-like protein potato_inhibit PF00280.18 CRG83808.1 - 0.093 13.4 0.1 0.19 12.4 0.1 1.6 1 1 0 1 1 1 0 Potato inhibitor I family Fungal_lectin_2 PF18647.1 CRG83809.1 - 0.81 10.2 3.2 1.4 9.4 0.0 2.7 3 0 0 3 3 3 0 Alpha-galactosyl-binding fungal lectin Ndc1_Nup PF09531.10 CRG83809.1 - 7.6 5.1 14.8 0.86 8.2 4.6 2.3 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Aldedh PF00171.22 CRG83810.1 - 2.3e-128 428.6 0.2 3e-128 428.3 0.2 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CRG83810.1 - 6.7e-05 22.1 0.0 0.00017 20.7 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF92 PF01940.16 CRG83811.1 - 1.9e-83 279.5 8.2 2.4e-83 279.2 8.2 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 Mobilization_B PF17511.2 CRG83811.1 - 0.0068 16.8 1.2 2.2 8.6 0.2 2.6 2 0 0 2 2 2 2 Mobilization protein B TFIIA_gamma_C PF02751.14 CRG83814.1 - 4.5e-26 90.7 2.1 7e-26 90.1 2.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 CRG83814.1 - 9.6e-24 83.2 0.2 1.3e-23 82.7 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Hexokinase_1 PF00349.21 CRG83815.1 - 1.5e-61 207.8 0.0 2.1e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CRG83815.1 - 1.7e-43 148.8 0.0 8e-43 146.6 0.0 1.9 1 1 0 1 1 1 1 Hexokinase K_oxygenase PF13434.6 CRG83815.1 - 0.21 10.7 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) GILT PF03227.16 CRG83816.1 - 7.1e-15 55.2 0.9 1.6e-14 54.0 0.9 1.7 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) MFS_1 PF07690.16 CRG83817.1 - 5.3e-32 111.1 28.1 8.1e-32 110.5 28.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG83817.1 - 0.0095 14.8 4.9 0.058 12.2 1.5 2.3 1 1 1 2 2 2 2 MFS_1 like family DUF2070 PF09843.9 CRG83817.1 - 8.8 4.5 8.1 18 3.5 8.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) adh_short_C2 PF13561.6 CRG83818.1 - 4.6e-55 186.7 0.7 5.8e-55 186.4 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83818.1 - 5.3e-44 150.0 0.2 6.6e-44 149.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG83818.1 - 2.7e-13 50.2 0.4 4.2e-13 49.6 0.4 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG83818.1 - 1.9e-06 27.5 0.1 2.9e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG83818.1 - 0.00014 21.4 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Glu_dehyd_C PF16912.5 CRG83818.1 - 0.032 13.7 0.0 1.7 8.0 0.0 2.2 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus GCP_N_terminal PF17681.1 CRG83819.1 - 5.1e-34 118.3 0.0 9.1e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CRG83819.1 - 1.8e-21 76.9 0.0 4.5e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal ThiF PF00899.21 CRG83820.1 - 9.1e-114 378.9 0.0 1.4e-75 253.8 0.0 2.6 3 0 0 3 3 3 2 ThiF family UBA_e1_thiolCys PF10585.9 CRG83820.1 - 2.1e-98 329.2 0.4 7.3e-97 324.2 0.5 2.3 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 CRG83820.1 - 1.4e-29 102.1 0.1 2.7e-29 101.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 CRG83820.1 - 3.1e-29 101.5 0.0 6.5e-29 100.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 CRG83820.1 - 4.2e-26 90.9 1.4 1e-25 89.7 1.4 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle GST_N_2 PF13409.6 CRG83820.1 - 4.2e-20 71.8 0.0 1.1e-19 70.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG83820.1 - 3.1e-15 55.9 0.0 1e-14 54.3 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG83820.1 - 8.3e-06 25.9 0.0 3e-05 24.1 0.0 1.9 2 0 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG83820.1 - 0.00062 20.1 0.1 0.0074 16.7 0.1 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain NAD_binding_7 PF13241.6 CRG83820.1 - 0.084 13.3 0.1 1.8 9.0 0.0 3.2 4 1 0 4 4 4 0 Putative NAD(P)-binding GST_C_3 PF14497.6 CRG83820.1 - 0.13 12.4 0.1 0.42 10.8 0.1 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Mito_carr PF00153.27 CRG83821.1 - 4.4e-66 218.9 3.8 1.4e-23 82.6 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 CRG83821.1 - 2.6e-20 70.4 3.4 0.00016 21.0 0.0 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CRG83821.1 - 5.7e-20 71.5 4.7 2.9e-10 40.4 1.4 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CRG83821.1 - 6.5e-18 63.1 6.2 2.8e-05 23.7 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CRG83821.1 - 3.5e-15 54.7 6.3 9.9e-05 21.7 0.2 3.6 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 CRG83821.1 - 1.9e-10 40.4 2.3 0.00014 21.6 0.1 3.8 2 2 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CRG83821.1 - 1.6e-08 34.9 0.2 0.00016 22.0 0.2 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 CRG83821.1 - 0.00032 20.5 0.5 0.64 9.9 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_14 PF17959.1 CRG83821.1 - 0.008 16.5 0.3 0.53 10.7 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain Arch_fla_DE PF04659.13 CRG83821.1 - 0.059 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Archaeal flagella protein DUF1456 PF07308.13 CRG83821.1 - 0.14 12.5 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1456) SurA_N_3 PF13624.6 CRG83821.1 - 0.17 11.6 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 SurA N-terminal domain Cyclin_N PF00134.23 CRG83822.1 - 3.5e-12 46.2 0.9 6.9e-12 45.2 0.9 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 CRG83822.1 - 0.073 13.5 0.3 0.35 11.3 0.0 2.2 2 0 0 2 2 2 0 Cyclin C-terminal domain DUF1421 PF07223.11 CRG83822.1 - 0.1 12.5 0.2 17 5.3 0.0 2.4 2 0 0 2 2 2 0 UBA-like domain (DUF1421) DUF4452 PF14618.6 CRG83823.1 - 1.5e-74 249.4 8.2 2.4e-74 248.9 8.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) SNARE PF05739.19 CRG83825.1 - 1.3e-08 34.7 1.9 2e-08 34.1 1.9 1.3 1 0 0 1 1 1 1 SNARE domain HrpB7 PF09486.10 CRG83825.1 - 0.0023 18.3 1.4 0.003 17.9 0.3 1.7 2 0 0 2 2 2 1 Bacterial type III secretion protein (HrpB7) XhlA PF10779.9 CRG83825.1 - 0.038 14.2 2.3 0.039 14.2 0.1 2.2 3 0 0 3 3 3 0 Haemolysin XhlA zf-TRAF PF02176.18 CRG83826.1 - 3.4e-09 37.2 39.2 4.2e-06 27.4 7.7 4.8 2 1 3 5 5 5 4 TRAF-type zinc finger zf-RING_UBOX PF13445.6 CRG83826.1 - 1.1e-06 28.6 13.5 1.1e-06 28.6 13.5 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-TRAF_2 PF15965.5 CRG83826.1 - 4.8e-06 27.0 35.8 5.4e-06 26.8 11.5 2.9 2 1 2 4 4 3 2 TRAF-like zinc-finger zf-ACC PF17848.1 CRG83826.1 - 5.1e-06 26.5 12.9 0.00081 19.4 0.3 4.7 4 0 0 4 4 4 2 Acetyl-coA carboxylase zinc finger domain zf-RING_2 PF13639.6 CRG83826.1 - 9.5e-06 25.9 14.7 9.5e-06 25.9 14.7 3.6 2 1 1 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 CRG83826.1 - 1.8e-05 24.8 13.2 1.8e-05 24.8 13.2 2.6 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CRG83826.1 - 9.5e-05 22.3 12.7 9.5e-05 22.3 12.7 3.2 2 1 0 2 2 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CRG83826.1 - 0.00021 21.1 14.2 0.00021 21.1 14.2 3.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG83826.1 - 0.017 15.0 14.2 0.017 15.0 14.2 3.9 5 1 0 5 5 5 0 Zinc finger, C3HC4 type (RING finger) zf_C2HC_14 PF18574.1 CRG83826.1 - 0.033 14.0 4.2 0.11 12.3 0.0 3.2 3 0 0 3 3 3 0 C2HC Zing finger domain Sina PF03145.16 CRG83826.1 - 0.19 11.7 19.8 1 9.3 5.1 2.5 1 1 1 2 2 2 0 Seven in absentia protein family DFRP_C PF16543.5 CRG83827.1 - 4.9e-26 91.0 7.7 4.9e-26 91.0 7.7 3.7 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH_4 PF18044.1 CRG83827.1 - 1.6e-05 24.6 11.0 0.00055 19.7 3.2 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH PF00642.24 CRG83827.1 - 0.00012 21.9 3.1 0.00012 21.9 3.1 2.4 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CRG83827.1 - 0.00014 22.5 17.2 0.00024 21.7 5.9 3.7 3 2 0 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 CRG83827.1 - 0.0051 16.8 9.1 0.0051 16.8 9.1 3.3 4 0 0 4 4 4 2 Zinc finger domain zf-CCCH_2 PF14608.6 CRG83827.1 - 0.044 14.3 14.3 0.41 11.2 4.9 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 CRG83827.1 - 0.062 13.5 7.8 0.42 10.8 0.1 3.0 3 1 0 3 3 3 0 Zinc-finger containing family PTPS PF01242.19 CRG83827.1 - 0.073 13.0 0.2 2.9 7.9 0.0 2.4 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase LRS4 PF10422.9 CRG83827.1 - 0.78 9.3 10.0 0.58 9.7 4.3 2.3 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 DAO PF01266.24 CRG83828.1 - 4.4e-25 89.0 0.5 1.9e-24 86.9 0.2 1.9 2 1 0 3 3 3 1 FAD dependent oxidoreductase adh_short PF00106.25 CRG83828.1 - 3.1e-24 85.5 0.0 4.8e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83828.1 - 3e-20 72.8 0.0 5.1e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83828.1 - 0.0073 16.2 0.0 0.018 15.0 0.0 1.7 2 0 0 2 2 2 1 KR domain DUF460 PF04312.13 CRG83828.1 - 0.1 12.3 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF460) DUF1776 PF08643.10 CRG83828.1 - 0.19 11.0 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) NACHT_N PF17100.5 CRG83829.1 - 2.3e-63 214.0 0.6 7.2e-63 212.4 0.1 2.0 2 0 0 2 2 2 1 N-terminal domain of NWD NACHT-NTPase Ank_2 PF12796.7 CRG83829.1 - 1.1e-40 138.1 1.2 4.3e-15 56.1 0.3 4.8 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG83829.1 - 9e-35 118.6 0.1 2.7e-10 40.6 0.0 5.3 2 1 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83829.1 - 1.2e-29 99.0 0.0 0.0079 16.6 0.0 8.0 7 0 0 7 7 7 7 Ankyrin repeat Ank PF00023.30 CRG83829.1 - 4.7e-26 90.0 0.2 0.016 15.7 0.0 8.7 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 CRG83829.1 - 1e-23 83.1 6.6 1.8e-06 28.1 0.0 6.2 2 1 4 6 6 6 4 Ankyrin repeats (many copies) NACHT PF05729.12 CRG83829.1 - 1.7e-05 24.8 0.0 3.7e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG83829.1 - 0.00011 22.7 0.0 0.00078 19.9 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CRG83829.1 - 0.00062 20.2 0.0 0.0023 18.3 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG83829.1 - 0.0024 18.2 0.0 0.0083 16.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Goodbye PF17109.5 CRG83829.1 - 0.031 14.7 0.0 0.12 12.9 0.0 2.0 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain AAA_33 PF13671.6 CRG83829.1 - 0.12 12.6 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain VWA_3_C PF18571.1 CRG83829.1 - 2.5 8.0 9.4 89 3.1 0.0 5.7 7 0 0 7 7 7 0 von Willebrand factor type A C-terminal domain Pro-kuma_activ PF09286.11 CRG83830.1 - 2.1e-34 118.9 0.1 3.3e-33 115.0 0.1 2.6 3 0 0 3 3 3 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG83830.1 - 3.7e-08 33.0 0.5 6.1e-08 32.3 0.5 1.2 1 0 0 1 1 1 1 Subtilase family TPR_1 PF00515.28 CRG83831.1 - 2.9e-06 26.8 0.0 2.9e-06 26.8 0.0 4.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG83831.1 - 4.9e-06 26.3 0.0 4.9e-06 26.3 0.0 5.6 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG83831.1 - 0.00068 19.7 4.3 0.11 12.7 0.0 5.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG83831.1 - 0.012 15.6 1.3 0.47 10.6 0.0 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 CRG83831.1 - 0.039 13.6 12.1 0.21 11.3 0.0 4.9 5 0 0 5 5 5 0 TPR repeat TPR_9 PF13371.6 CRG83831.1 - 0.046 13.9 0.1 3.4 7.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG83831.1 - 0.071 13.8 13.7 2.2 9.0 0.1 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat Acyltransf_C PF16076.5 CRG83831.1 - 0.15 12.2 0.1 0.44 10.7 0.1 1.7 1 0 0 1 1 1 0 Acyltransferase C-terminus TPR_14 PF13428.6 CRG83831.1 - 0.25 12.2 12.0 2.7 9.1 0.1 5.7 6 1 0 6 6 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 CRG83831.1 - 0.51 10.8 4.0 28 5.4 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CRG83831.1 - 7.1 7.0 12.3 80 3.6 2.6 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat PHD_4 PF16866.5 CRG83832.1 - 0.07 13.2 5.3 3.8 7.7 0.2 2.4 1 1 1 2 2 2 0 PHD-finger RasGEF PF00617.19 CRG83833.1 - 0.064 13.5 0.1 0.16 12.1 0.0 1.7 2 0 0 2 2 2 0 RasGEF domain Glyco_tranf_2_4 PF13704.6 CRG83833.1 - 0.19 12.3 2.2 2.1 8.9 0.5 2.5 2 0 0 2 2 2 0 Glycosyl transferase family 2 WD40 PF00400.32 CRG83834.1 - 0.6 11.1 2.4 1.1 10.2 0.1 2.7 3 0 0 3 3 3 0 WD domain, G-beta repeat Ependymin PF00811.18 CRG83835.1 - 0.013 15.8 0.6 0.027 14.7 0.1 1.8 2 0 0 2 2 2 0 Ependymin DUF5305 PF17231.2 CRG83835.1 - 0.024 14.0 0.2 0.039 13.3 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) POM121 PF15229.6 CRG83835.1 - 0.09 12.4 4.9 0.22 11.1 4.9 1.6 1 0 0 1 1 1 0 POM121 family DUF3188 PF11384.8 CRG83835.1 - 0.23 11.2 1.9 0.44 10.3 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) 2OG-FeII_Oxy_2 PF13532.6 CRG83836.1 - 4.4e-25 89.0 0.0 6.6e-25 88.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Mid2 PF04478.12 CRG83837.1 - 0.0052 16.6 0.3 0.014 15.2 0.3 1.7 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Methyltransf_2 PF00891.18 CRG83838.1 - 1.2e-29 103.2 0.0 1.7e-29 102.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 CRG83838.1 - 8.6e-05 22.4 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG83838.1 - 0.00016 22.3 0.0 0.00042 21.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG83838.1 - 0.027 15.2 0.0 0.054 14.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Luciferase_3H PF10284.9 CRG83838.1 - 0.17 12.0 0.0 0.4 10.9 0.0 1.5 1 0 0 1 1 1 0 Luciferase helical bundle domain PTR2 PF00854.21 CRG83840.1 - 3.6e-56 190.7 6.7 4.8e-56 190.3 6.7 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CRG83840.1 - 1.1e-06 27.8 30.3 8.7e-05 21.6 13.2 2.6 2 1 1 3 3 3 3 Major Facilitator Superfamily TssN PF17555.2 CRG83840.1 - 0.36 10.2 8.0 3 7.1 0.3 3.2 3 0 0 3 3 3 0 Type VI secretion system, TssN Phage_holin_3_6 PF07332.11 CRG83840.1 - 8 6.5 20.5 0.29 11.2 0.4 3.4 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Sugar_tr PF00083.24 CRG83841.1 - 3.3e-64 217.4 14.7 3.5e-63 214.0 15.0 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG83841.1 - 8.7e-18 64.4 30.7 6.7e-17 61.4 7.3 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1275 PF06912.11 CRG83842.1 - 1.6e-44 152.1 8.2 1.9e-44 151.9 8.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) DUF3953 PF13129.6 CRG83842.1 - 3.9 7.3 0.0 3.9 7.3 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF3953) Abhydrolase_1 PF00561.20 CRG83843.1 - 3.9e-20 72.6 0.0 7.6e-19 68.4 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG83843.1 - 2.8e-18 67.4 0.0 5.2e-18 66.5 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG83843.1 - 0.017 14.4 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 EHN PF06441.12 CRG83843.1 - 0.021 15.2 0.1 0.057 13.8 0.1 1.8 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Glu_syn_central PF04898.14 CRG83843.1 - 0.18 11.2 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Glutamate synthase central domain FlaG PF03646.15 CRG83844.1 - 1.6e-08 34.6 0.5 0.16 12.2 0.0 3.5 3 0 0 3 3 3 3 FlaG protein Cytochrom_D1 PF02239.16 CRG83844.1 - 5.2e-06 25.2 0.0 0.0024 16.5 0.0 3.2 4 0 0 4 4 4 2 Cytochrome D1 heme domain YfkB PF08756.10 CRG83844.1 - 0.0076 16.1 0.0 0.03 14.1 0.0 1.9 2 0 0 2 2 2 1 YfkB-like domain TolB_like PF15869.5 CRG83844.1 - 0.11 11.7 0.0 0.79 8.9 0.0 2.0 2 0 0 2 2 2 0 TolB-like 6-blade propeller-like PD40 PF07676.12 CRG83844.1 - 0.21 11.6 0.6 52 3.9 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Ank_2 PF12796.7 CRG83846.1 - 2.9e-36 123.9 0.0 2.5e-10 40.8 0.0 7.4 4 2 5 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG83846.1 - 2.7e-25 88.4 1.0 0.0083 16.7 0.0 8.7 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG83846.1 - 9.1e-23 80.0 2.1 0.0046 17.2 0.0 9.6 8 3 3 11 11 11 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83846.1 - 3.4e-20 70.0 3.5 0.11 13.1 0.1 12.3 12 0 0 12 12 12 4 Ankyrin repeat Ank PF00023.30 CRG83846.1 - 1.3e-17 63.4 8.2 0.0096 16.3 0.3 9.9 11 0 0 11 11 11 4 Ankyrin repeat F-box-like PF12937.7 CRG83846.1 - 0.0046 16.8 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like adh_short PF00106.25 CRG83847.1 - 4.5e-12 45.8 0.1 1.2e-11 44.4 0.1 1.7 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83847.1 - 7.5e-07 28.9 0.0 1.1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83847.1 - 0.0002 21.3 0.1 0.0003 20.8 0.1 1.2 1 0 0 1 1 1 1 KR domain Ank_4 PF13637.6 CRG83848.1 - 7.5e-20 71.0 1.3 2.1e-06 28.2 0.1 4.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG83848.1 - 2e-16 60.3 1.9 1.9e-09 38.0 0.3 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 CRG83848.1 - 2.4e-13 49.9 3.3 0.0076 16.7 0.2 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 CRG83848.1 - 2.1e-12 47.0 0.9 7.7e-06 26.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83848.1 - 6.8e-12 44.5 1.0 0.35 11.6 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat BRCC36_C PF18110.1 CRG83848.1 - 0.096 12.9 0.1 0.27 11.4 0.1 1.7 1 0 0 1 1 1 0 BRCC36 C-terminal helical domain WXG100 PF06013.12 CRG83848.1 - 0.3 11.3 5.7 2.1 8.6 0.3 3.0 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Fungal_trans_2 PF11951.8 CRG83849.1 - 2.3e-53 181.4 0.0 4.1e-53 180.6 0.0 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83849.1 - 7.3e-05 22.8 5.5 0.00015 21.8 5.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3385 PF11865.8 CRG83849.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) Mannosyl_trans3 PF11051.8 CRG83850.1 - 2e-55 188.1 0.0 9.8e-36 123.5 0.0 2.2 1 1 1 2 2 2 2 Mannosyltransferase putative GET2 PF08690.10 CRG83850.1 - 0.18 11.5 0.1 0.56 9.8 0.0 1.7 2 0 0 2 2 2 0 GET complex subunit GET2 Sin_N PF04801.13 CRG83851.1 - 1 8.5 12.1 1.2 8.2 12.1 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region BCIP PF13862.6 CRG83852.1 - 2.7e-73 246.1 0.1 3.7e-73 245.7 0.1 1.2 1 0 0 1 1 1 1 p21-C-terminal region-binding protein CM_2 PF01817.21 CRG83853.1 - 0.0013 19.1 1.4 0.051 13.9 0.1 2.9 3 1 0 3 3 3 1 Chorismate mutase type II DUF1910 PF08928.10 CRG83853.1 - 0.059 13.4 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) Myelin_MBP PF01669.17 CRG83853.1 - 0.2 12.3 0.0 0.33 11.6 0.0 1.3 1 0 0 1 1 1 0 Myelin basic protein WD40 PF00400.32 CRG83854.1 - 1.4e-29 101.7 10.9 3.5e-06 27.6 0.6 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 CRG83854.1 - 5e-09 35.3 3.1 0.059 12.0 0.2 4.9 3 1 2 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CRG83854.1 - 1.8e-07 31.3 0.1 0.12 12.7 0.0 4.9 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1664 PF07889.12 CRG83854.1 - 0.084 12.9 0.5 0.46 10.5 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 CRG83854.1 - 0.38 11.3 2.1 0.78 10.3 2.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4164 PF13747.6 CRG83854.1 - 1.5 9.1 4.7 0.66 10.3 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Sad1_UNC PF07738.13 CRG83855.1 - 3.6e-12 46.4 0.0 1e-07 32.0 0.0 2.5 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal Kinesin PF00225.23 CRG83856.1 - 1.2e-88 297.3 0.0 1.2e-88 297.3 0.0 3.3 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 CRG83856.1 - 1.3e-19 70.6 0.0 1.4e-15 57.5 0.0 3.5 3 0 0 3 3 3 2 Microtubule binding Filament PF00038.21 CRG83856.1 - 0.0054 16.4 6.9 0.0054 16.4 6.9 10.3 5 4 5 10 10 10 4 Intermediate filament protein SLATT_5 PF18160.1 CRG83856.1 - 0.02 14.2 1.0 0.084 12.2 1.0 2.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF4108 PF13390.6 CRG83856.1 - 0.027 14.4 2.6 8.6 6.3 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) Polo_box_3 PF18544.1 CRG83856.1 - 1 10.0 5.1 14 6.4 0.1 4.2 3 0 0 3 3 3 0 Polo box domain SirA PF10747.9 CRG83856.1 - 4.8 7.5 8.5 1.9 8.8 2.5 3.3 2 0 0 2 2 2 0 Sporulation inhibitor of replication protein SirA Glycos_transf_1 PF00534.20 CRG83857.1 - 1.4e-31 109.4 0.2 2.6e-30 105.2 0.2 2.1 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CRG83857.1 - 4.9e-18 65.7 0.0 1e-16 61.4 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 CRG83857.1 - 2.2e-14 54.0 0.0 5.6e-14 52.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CRG83857.1 - 3.6e-06 27.5 0.2 9e-06 26.2 0.2 1.7 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 CRG83857.1 - 0.00049 20.4 0.0 0.001 19.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_5 PF16994.5 CRG83857.1 - 0.071 12.7 0.0 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 Glycosyl-transferase family 4 Spc7_N PF15402.6 CRG83859.1 - 0.026 12.8 1.7 0.034 12.4 1.7 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF1192 PF06698.11 CRG83859.1 - 0.25 11.4 1.1 0.56 10.3 1.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Axin_b-cat_bind PF08833.10 CRG83859.1 - 0.47 10.6 3.2 0.47 10.6 0.0 2.3 2 1 0 2 2 2 0 Axin beta-catenin binding domain MFS_1 PF07690.16 CRG83860.1 - 5.7e-40 137.3 46.9 8.6e-29 100.5 18.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG83860.1 - 1.3e-10 40.8 10.1 1.3e-10 40.8 10.1 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 CRG83860.1 - 1.6e-09 36.7 14.2 1.4e-06 27.1 7.3 2.3 1 1 1 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DUF2530 PF10745.9 CRG83860.1 - 0.058 13.6 0.3 0.058 13.6 0.3 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF2530) ERCC4 PF02732.15 CRG83861.1 - 6.3e-32 110.9 0.7 1.3e-31 110.0 0.7 1.5 1 0 0 1 1 1 1 ERCC4 domain RR_TM4-6 PF06459.12 CRG83861.1 - 0.4 10.5 15.0 0.39 10.5 10.9 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 SpoIIP PF07454.11 CRG83861.1 - 1.1 8.7 12.7 3.2 7.1 6.5 2.2 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) eIF3_subunit PF08597.10 CRG83861.1 - 3.1 7.7 24.2 0.022 14.7 12.6 2.8 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit Vfa1 PF08432.10 CRG83861.1 - 3.4 8.0 22.3 0.46 10.8 14.3 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Trnau1ap PF17654.1 CRG83861.1 - 7.5 7.5 8.1 5.7 7.9 1.4 2.5 2 0 0 2 2 2 0 Selenocysteine tRNA 1 associated proteins MFS_1 PF07690.16 CRG83862.1 - 5.2e-15 55.2 10.3 1.1e-12 47.6 2.2 3.0 2 1 1 3 3 3 3 Major Facilitator Superfamily Nodulin-like PF06813.13 CRG83862.1 - 4.4e-06 26.4 5.4 4.4e-06 26.4 5.4 1.8 2 1 0 2 2 2 1 Nodulin-like DUF5345 PF17280.2 CRG83862.1 - 0.43 10.6 0.0 0.43 10.6 0.0 4.1 5 0 0 5 5 5 0 Family of unknown function (DUF5345) Abhydrolase_3 PF07859.13 CRG83863.1 - 1.4e-31 110.1 0.0 3.8e-31 108.6 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CRG83863.1 - 0.034 13.0 0.0 0.08 11.8 0.0 1.5 2 0 0 2 2 2 0 Carboxylesterase family Say1_Mug180 PF10340.9 CRG83863.1 - 0.15 10.9 0.0 0.52 9.1 0.0 1.8 2 1 0 2 2 2 0 Steryl acetyl hydrolase MFS_1 PF07690.16 CRG83864.1 - 3.3e-22 78.9 46.0 9.2e-22 77.4 37.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 CRG83864.1 - 3.6e-12 47.1 0.0 6.4e-12 46.3 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG83864.1 - 5.1e-12 46.2 0.1 1.6e-11 44.6 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Sugar_tr PF00083.24 CRG83864.1 - 7.6e-05 21.7 14.8 7.6e-05 21.7 14.8 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter DUF441 PF04284.13 CRG83864.1 - 0.033 14.2 0.5 0.31 11.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF441) MFS_1 PF07690.16 CRG83865.1 - 4e-18 65.5 54.6 1.2e-17 63.9 36.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4492 PF14899.6 CRG83866.1 - 0.016 15.1 1.0 6.3 6.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) Prp18 PF02840.15 CRG83866.1 - 0.19 11.8 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Prp18 domain p450 PF00067.22 CRG83867.1 - 8e-31 107.3 0.0 1.6e-30 106.3 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 TAXi_C PF14541.6 CRG83867.1 - 0.0057 16.4 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Amino_oxidase PF01593.24 CRG83868.1 - 6.5e-15 55.4 0.0 4.2e-14 52.7 0.0 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CRG83868.1 - 1.5e-11 44.4 0.0 3.2e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG83868.1 - 3.5e-06 26.8 0.3 2.7e-05 23.9 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG83868.1 - 7.7e-06 25.3 0.2 0.0064 15.8 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG83868.1 - 5.3e-05 23.2 0.0 0.073 13.1 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Med16 PF11635.8 CRG83868.1 - 0.21 9.5 0.0 0.34 8.8 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 16 IPK PF03770.16 CRG83869.1 - 6.6e-59 199.1 0.6 1.4e-58 198.1 0.1 1.8 2 0 0 2 2 2 1 Inositol polyphosphate kinase Pam17 PF08566.10 CRG83869.1 - 0.063 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 LRR_4 PF12799.7 CRG83870.1 - 2e-28 97.9 34.8 2.6e-05 24.5 0.2 8.7 6 1 0 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG83870.1 - 1.9e-19 69.1 35.8 4e-05 23.3 1.9 8.0 4 1 7 11 11 11 9 Leucine rich repeat LRR_9 PF14580.6 CRG83870.1 - 9.7e-10 38.2 9.1 0.0012 18.4 0.8 5.1 2 1 2 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 CRG83870.1 - 0.17 12.0 19.8 10 6.5 0.1 8.2 9 0 0 9 9 9 0 Leucine Rich repeat LRR_1 PF00560.33 CRG83870.1 - 0.37 11.5 29.1 20 6.2 1.2 10.3 9 1 0 9 9 9 0 Leucine Rich Repeat PAN_1 PF00024.26 CRG83871.1 - 3.2e-09 36.6 7.0 0.018 15.0 0.9 3.4 3 0 0 3 3 3 3 PAN domain PTP_tm PF18861.1 CRG83871.1 - 0.012 15.6 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J G6B PF15096.6 CRG83871.1 - 0.043 13.6 0.0 0.092 12.5 0.0 1.6 1 0 0 1 1 1 0 G6B family PAN_4 PF14295.6 CRG83871.1 - 0.049 13.6 0.4 0.049 13.6 0.4 3.1 3 0 0 3 3 3 0 PAN domain TrbC PF04956.13 CRG83871.1 - 0.073 13.3 0.2 0.17 12.1 0.0 1.7 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF2681 PF10883.8 CRG83871.1 - 0.22 12.0 0.0 0.4 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Clathrin PF00637.20 CRG83872.1 - 8.8e-22 77.5 2.0 6.7e-20 71.4 1.1 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.8 CRG83872.1 - 8.3e-20 70.7 0.8 2.2e-19 69.4 0.8 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 CRG83872.1 - 1.3e-06 28.3 7.0 2.3e-06 27.5 7.0 1.4 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 CRG83872.1 - 1.5e-05 24.8 7.5 3e-05 23.8 7.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG83872.1 - 0.00058 19.8 7.1 0.0011 18.8 7.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain TPR_11 PF13414.6 CRG83872.1 - 0.0016 18.1 0.3 0.0038 16.9 0.3 1.6 1 0 0 1 1 1 1 TPR repeat zf-RING_2 PF13639.6 CRG83872.1 - 0.0022 18.3 7.1 0.0042 17.4 7.1 1.5 1 0 0 1 1 1 1 Ring finger domain TPR_14 PF13428.6 CRG83872.1 - 0.034 15.0 0.1 0.8 10.7 0.0 3.3 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-rbx1 PF12678.7 CRG83872.1 - 0.044 14.1 5.2 0.096 13.0 5.2 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CRG83872.1 - 0.054 13.4 6.3 0.099 12.5 6.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4810 PF16068.5 CRG83872.1 - 0.066 13.8 0.1 14 6.3 0.0 3.1 3 0 0 3 3 2 0 Domain of unknown function (DUF4810) TPR_2 PF07719.17 CRG83872.1 - 0.094 12.9 0.8 0.42 10.8 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat FliS PF02561.14 CRG83872.1 - 0.16 12.2 3.6 9.1 6.6 0.0 3.7 3 0 0 3 3 3 0 Flagellar protein FliS TPR_12 PF13424.6 CRG83872.1 - 0.17 12.2 1.6 1.1 9.6 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 CRG83872.1 - 1.1 9.3 6.8 3 8.0 6.8 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Ribosomal_L27A PF00828.19 CRG83873.1 - 0.53 11.0 3.1 1.4 9.6 3.1 1.7 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Fzo_mitofusin PF04799.13 CRG83873.1 - 1.5 8.3 19.7 1.6 8.3 9.1 2.7 1 1 1 2 2 2 0 fzo-like conserved region Spc7 PF08317.11 CRG83873.1 - 1.6 7.6 31.9 0.1 11.4 9.3 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Acetyltransf_1 PF00583.25 CRG83874.1 - 2.3e-09 37.5 0.0 8.6e-09 35.7 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG83874.1 - 2e-08 34.2 0.0 3.6e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG83874.1 - 7.3e-07 29.5 0.0 1.2e-06 28.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG83874.1 - 0.14 12.2 0.0 0.82 9.8 0.0 1.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain 7TMR-HDED PF07697.11 CRG83875.1 - 0.02 15.1 0.1 0.023 14.8 0.1 1.1 1 0 0 1 1 1 0 7TM-HD extracellular RAD51_interact PF15696.5 CRG83876.1 - 0.023 14.8 0.1 0.06 13.5 0.1 1.7 1 0 0 1 1 1 0 RAD51 interacting motif AT_hook PF02178.19 CRG83876.1 - 7 6.9 25.3 0.12 12.3 2.7 3.9 3 0 0 3 3 3 0 AT hook motif Polysacc_deac_1 PF01522.21 CRG83877.1 - 6.2e-28 97.2 0.2 3.7e-27 94.7 0.0 2.3 3 0 0 3 3 3 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 CRG83877.1 - 1.4e-05 25.5 16.9 2.7e-05 24.5 16.9 1.5 1 0 0 1 1 1 1 Chitin recognition protein RTP1_C1 PF10363.9 CRG83878.1 - 1.2e-32 112.4 0.6 5e-31 107.2 0.1 3.3 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 CRG83878.1 - 2.2e-08 33.6 0.0 2.9e-07 30.1 0.0 2.6 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 2 M20_dimer PF07687.14 CRG83878.1 - 0.14 12.1 0.2 4.5 7.2 0.1 3.0 2 1 0 2 2 2 0 Peptidase dimerisation domain Arm_3 PF16186.5 CRG83878.1 - 0.18 11.4 0.0 0.48 10.0 0.0 1.7 1 0 0 1 1 1 0 Atypical Arm repeat DBR1 PF05011.13 CRG83879.1 - 7.5e-39 133.3 0.0 1.6e-38 132.3 0.0 1.6 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 CRG83879.1 - 1.8e-06 28.6 0.5 3e-06 27.9 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Rpr2 PF04032.16 CRG83880.1 - 6.9e-09 35.9 1.3 6.9e-09 35.9 1.3 1.9 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Paired_CXXCH_1 PF09699.10 CRG83880.1 - 0.072 12.8 1.6 0.23 11.2 0.2 2.2 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) C1_2 PF03107.16 CRG83880.1 - 0.079 13.3 0.6 0.82 10.0 0.1 2.2 2 0 0 2 2 2 0 C1 domain zf-ZPR1 PF03367.13 CRG83881.1 - 3.3e-104 345.6 2.4 2.2e-54 183.6 0.0 2.5 3 0 0 3 3 3 2 ZPR1 zinc-finger domain DUF4028 PF13220.6 CRG83881.1 - 0.053 13.3 0.0 0.28 11.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4028) zf-RRPl_C4 PF17026.5 CRG83881.1 - 0.24 11.5 1.6 4 7.6 0.2 2.3 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-H2C2_5 PF13909.6 CRG83881.1 - 1.9 8.3 4.7 22 4.9 1.0 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Pro_isomerase PF00160.21 CRG83882.1 - 5.5e-34 117.7 0.0 3e-33 115.3 0.0 1.9 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Arrestin_C PF02752.22 CRG83883.1 - 2.8e-12 47.2 0.0 1.6e-11 44.8 0.0 2.0 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain adh_short_C2 PF13561.6 CRG83885.1 - 7.7e-35 120.5 1.3 7.8e-30 104.2 0.2 2.4 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83885.1 - 3e-34 118.2 2.2 3e-23 82.3 0.4 2.4 1 1 0 2 2 2 2 short chain dehydrogenase tRNA_int_end_N2 PF12928.7 CRG83885.1 - 4.8e-25 87.5 0.0 9.3e-25 86.6 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term KR PF08659.10 CRG83885.1 - 5.1e-09 36.3 3.0 9.1e-08 32.2 3.0 2.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG83885.1 - 0.00073 19.1 0.0 0.0029 17.1 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CRG83885.1 - 0.12 12.4 0.1 0.54 10.3 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CRG83886.1 - 1.6e-72 243.8 0.0 2.2e-72 243.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 CRG83886.1 - 1.1e-19 70.8 0.4 2.5e-19 69.6 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 CRG83886.1 - 3.3e-06 27.2 1.3 8e-06 26.0 0.3 1.9 1 1 1 2 2 2 1 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 CRG83886.1 - 5e-05 23.7 0.1 0.00025 21.4 0.0 2.1 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CRG83886.1 - 0.031 14.3 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 CRG83886.1 - 0.084 13.4 0.1 3 8.5 0.0 2.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CM_2 PF01817.21 CRG83886.1 - 0.16 12.4 0.5 2.8 8.4 0.3 2.5 2 0 0 2 2 2 0 Chorismate mutase type II Q_salvage PF10343.9 CRG83887.1 - 5.5e-133 442.8 0.0 6.7e-133 442.6 0.0 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DUF1563 PF07599.11 CRG83887.1 - 0.16 12.1 0.6 0.3 11.2 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) DUF3658 PF12395.8 CRG83887.1 - 0.46 10.4 2.7 1.4 8.9 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function ORC6 PF05460.13 CRG83888.1 - 4.8e-84 282.7 1.0 5.5e-84 282.5 1.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) DNA_pol_delta_4 PF04081.13 CRG83889.1 - 8.6e-37 126.4 0.5 1.2e-36 125.9 0.5 1.2 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 Spore_coat_CotO PF14153.6 CRG83889.1 - 0.0092 15.9 1.1 0.012 15.6 1.1 1.1 1 0 0 1 1 1 1 Spore coat protein CotO Phage_integr_3 PF16795.5 CRG83889.1 - 0.023 14.6 0.0 0.092 12.7 0.0 1.8 1 1 1 2 2 2 0 Archaeal phage integrase Citrate_bind PF16114.5 CRG83890.1 - 1.8e-88 294.7 0.1 2.4e-88 294.3 0.1 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 CRG83890.1 - 1.2e-08 34.8 0.0 1.8e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain Citrate_synt PF00285.21 CRG83891.1 - 2.7e-20 72.8 0.0 6.2e-18 65.0 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain CoA_binding PF02629.19 CRG83891.1 - 8.8e-18 64.8 0.0 2.5e-17 63.4 0.0 1.8 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 CRG83891.1 - 1.4e-15 57.4 0.1 2.2e-15 56.8 0.1 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CRG83891.1 - 6.3e-05 22.8 0.0 0.00075 19.3 0.0 2.3 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CEP1-DNA_bind PF09287.10 CRG83891.1 - 0.16 11.6 0.0 0.35 10.5 0.0 1.5 1 0 0 1 1 1 0 CEP-1, DNA binding NifZ PF04319.13 CRG83891.1 - 0.17 11.7 0.5 0.98 9.3 0.6 2.2 2 0 0 2 2 2 0 NifZ domain RNase_P_Rpp14 PF01900.19 CRG83892.1 - 5.8e-35 119.6 0.0 7.9e-35 119.2 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family ATP_bind_1 PF03029.17 CRG83893.1 - 1.7e-76 257.2 0.0 2.2e-76 256.8 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein DJ-1_PfpI PF01965.24 CRG83893.1 - 1.2e-09 38.2 0.0 1.9e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family MeaB PF03308.16 CRG83893.1 - 0.002 17.1 0.0 0.0037 16.3 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_31 PF13614.6 CRG83893.1 - 0.0025 17.7 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_10 PF12846.7 CRG83893.1 - 0.012 14.6 0.0 0.019 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain MMR_HSR1 PF01926.23 CRG83893.1 - 0.012 15.6 0.0 0.1 12.7 0.0 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CRG83893.1 - 0.068 12.5 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin RuvB_N PF05496.12 CRG83893.1 - 0.097 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_17 PF13207.6 CRG83893.1 - 0.13 12.6 1.8 0.49 10.8 0.1 2.6 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 CRG83893.1 - 0.18 11.9 0.0 0.46 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 CRG83893.1 - 0.25 10.8 0.2 0.48 9.8 0.2 1.5 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MFS_1 PF07690.16 CRG83895.1 - 5.4e-31 107.8 35.3 5.4e-31 107.8 35.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily WD40 PF00400.32 CRG83896.1 - 1.4e-11 44.7 4.9 0.17 12.8 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG83896.1 - 0.0019 18.5 0.0 15 6.0 0.0 4.5 3 3 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Rib_5-P_isom_A PF06026.14 CRG83897.1 - 1.5e-46 158.1 0.0 2.7e-46 157.3 0.0 1.3 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 CRG83897.1 - 0.0082 16.1 0.1 4.2 7.3 0.1 2.2 2 0 0 2 2 2 2 DeoR C terminal sensor domain ThiF PF00899.21 CRG83898.1 - 4.9e-15 55.6 0.0 2.1e-14 53.5 0.0 2.2 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 CRG83898.1 - 0.0042 17.2 0.0 0.46 10.7 0.0 3.2 3 1 0 3 3 3 1 Ubiquitin-activating enzyme E1 four-helix bundle ANF_receptor PF01094.28 CRG83898.1 - 0.023 13.8 0.0 0.097 11.8 0.0 1.9 2 0 0 2 2 2 0 Receptor family ligand binding region Glyco_transf_25 PF01755.17 CRG83899.1 - 2.2e-05 24.4 0.0 0.00037 20.4 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 25 (LPS biosynthesis protein) zf-C3HC4_3 PF13920.6 CRG83901.1 - 2.1e-09 37.1 12.0 4.4e-09 36.1 12.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF5400 PF17379.2 CRG83901.1 - 0.59 10.6 4.8 0.14 12.6 0.6 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5400) 2OG-FeII_Oxy_3 PF13640.6 CRG83902.1 - 6e-10 39.9 0.4 6.2e-09 36.6 0.1 2.4 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily XAP5 PF04921.14 CRG83903.1 - 8.3e-87 291.1 0.0 1.3e-86 290.5 0.0 1.2 1 0 0 1 1 1 1 XAP5, circadian clock regulator DUF4604 PF15377.6 CRG83903.1 - 0.00089 19.7 3.9 0.00089 19.7 3.9 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4604) Fip1 PF05182.13 CRG83904.1 - 2.9e-21 74.7 1.2 5.1e-21 73.9 1.2 1.4 1 0 0 1 1 1 1 Fip1 motif Ribosomal_60s PF00428.19 CRG83904.1 - 4.5 7.9 9.0 3.2 8.4 4.9 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cpn10 PF00166.21 CRG83905.1 - 4e-29 100.5 0.0 4.4e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit TauD PF02668.16 CRG83907.1 - 6.7e-53 180.2 1.0 1.2e-52 179.4 0.6 1.6 1 1 1 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family Nucleoporin_FG PF13634.6 CRG83908.1 - 2.6e-20 73.1 109.0 2.5e-08 34.7 51.8 3.6 1 1 2 3 3 3 3 Nucleoporin FG repeat region Baculo_PEP_C PF04513.12 CRG83908.1 - 0.0011 19.0 7.7 0.38 10.8 0.0 2.6 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 CRG83908.1 - 0.058 13.4 0.6 3 7.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Neur_chan_memb PF02932.16 CRG83908.1 - 0.11 12.6 0.0 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF1351 PF07083.11 CRG83908.1 - 0.11 12.2 0.0 2.4 7.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) DUF5446 PF17522.2 CRG83908.1 - 0.14 12.3 0.4 0.51 10.5 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5446) TFIIA PF03153.13 CRG83908.1 - 0.56 10.1 14.9 0.87 9.5 14.9 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 CRG83909.1 - 9.6e-07 29.4 7.7 1.7 9.6 0.1 6.1 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG83909.1 - 0.037 14.3 0.0 5.7 7.3 0.0 3.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain HAD_2 PF13419.6 CRG83910.1 - 9e-16 58.5 0.0 1.3e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG83910.1 - 3.1e-10 40.7 0.0 2.7e-08 34.4 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG83910.1 - 0.0055 16.7 0.0 0.032 14.3 0.0 2.2 3 0 0 3 3 3 1 HAD-hyrolase-like NT5C PF06941.12 CRG83910.1 - 0.02 14.8 0.0 0.17 11.7 0.0 2.1 1 1 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Hydrolase_6 PF13344.6 CRG83910.1 - 0.083 13.0 0.0 2 8.6 0.0 2.4 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase COesterase PF00135.28 CRG83911.1 - 6.4e-53 180.4 0.0 1.2e-52 179.5 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG83911.1 - 1.4e-07 31.6 0.0 8.4e-07 29.1 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG83911.1 - 0.00019 22.1 0.7 0.00039 21.1 0.5 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Say1_Mug180 PF10340.9 CRG83911.1 - 0.033 13.0 0.0 0.27 10.1 0.0 2.0 1 1 0 1 1 1 0 Steryl acetyl hydrolase TPR_2 PF07719.17 CRG83911.1 - 0.21 11.8 3.1 23 5.4 0.4 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4407 PF14362.6 CRG83911.1 - 1.5 8.1 7.1 2.3 7.5 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_1 PF00515.28 CRG83911.1 - 1.5 8.8 3.9 12 5.9 0.7 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat COesterase PF00135.28 CRG83912.1 - 1.6e-58 198.8 0.0 1.2e-56 192.7 0.0 2.0 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG83912.1 - 0.00081 19.3 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG83912.1 - 0.021 14.1 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 HgmA PF04209.13 CRG83913.1 - 1.6e-162 541.1 0.1 1.8e-162 540.9 0.1 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Fungal_trans PF04082.18 CRG83914.1 - 6.4e-21 74.6 0.6 1.3e-20 73.6 0.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG83914.1 - 4.5e-06 26.8 13.3 0.0013 19.1 1.4 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG83914.1 - 0.00011 22.7 10.4 0.055 14.3 1.0 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HC_2 PF13913.6 CRG83914.1 - 1.1 9.2 8.8 0.37 10.7 3.0 2.5 2 0 0 2 2 2 0 zinc-finger of a C2HC-type LIM PF00412.22 CRG83914.1 - 1.1 9.5 4.1 2.5 8.4 4.1 1.6 1 0 0 1 1 1 0 LIM domain zf-H2C2_2 PF13465.6 CRG83914.1 - 2.8 8.5 16.2 0.37 11.3 5.3 3.3 3 0 0 3 3 3 0 Zinc-finger double domain adh_short_C2 PF13561.6 CRG83915.1 - 2.9e-33 115.4 0.0 8.9e-32 110.5 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG83915.1 - 6.5e-29 100.8 0.0 1.8e-28 99.3 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG83915.1 - 3.2e-07 30.5 0.3 8.1e-07 29.1 0.3 1.6 1 1 0 1 1 1 1 KR domain Pyr_redox PF00070.27 CRG83915.1 - 0.016 15.8 0.0 0.47 11.0 0.1 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG83915.1 - 0.033 13.4 0.1 0.043 13.1 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain ADH_zinc_N PF00107.26 CRG83915.1 - 0.073 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Metallophos PF00149.28 CRG83916.1 - 5.8e-38 131.5 0.4 9.7e-38 130.7 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CRG83916.1 - 0.028 14.9 0.0 0.057 13.9 0.0 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain PI31_Prot_N PF11566.8 CRG83917.1 - 2.7e-43 147.6 0.0 3.6e-43 147.2 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 CRG83917.1 - 3.9e-15 56.8 16.2 3.9e-15 56.8 16.2 3.0 3 0 0 3 3 3 1 PI31 proteasome regulator GYF PF02213.16 CRG83918.1 - 1.9e-17 62.6 0.3 3.9e-17 61.6 0.3 1.6 1 0 0 1 1 1 1 GYF domain Fis1_TPR_C PF14853.6 CRG83919.1 - 1.5e-25 89.0 0.8 2.2e-25 88.4 0.8 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 CRG83919.1 - 3.3e-16 58.7 0.1 3.3e-16 58.7 0.1 1.8 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat zf-RING_2 PF13639.6 CRG83919.1 - 2.2e-13 50.3 8.5 3.8e-13 49.6 8.5 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CRG83919.1 - 9.6e-11 41.2 2.4 1.7e-10 40.5 2.4 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CRG83919.1 - 2.7e-09 36.7 8.4 4.3e-09 36.1 8.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CRG83919.1 - 3e-07 30.6 7.5 6.9e-07 29.5 7.5 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CRG83919.1 - 2e-06 27.6 3.4 3.6e-06 26.7 3.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG83919.1 - 6.7e-06 25.9 7.7 1.1e-05 25.2 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG83919.1 - 8.5e-05 22.5 4.2 0.00018 21.5 4.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CRG83919.1 - 0.00026 20.9 5.4 0.00044 20.1 5.4 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG83919.1 - 0.00079 19.2 4.4 0.0014 18.4 4.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 TPR_2 PF07719.17 CRG83919.1 - 0.0098 15.9 1.0 0.02 15.0 1.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat zf-ANAPC11 PF12861.7 CRG83919.1 - 0.011 15.8 2.6 0.011 15.8 2.6 2.2 3 0 0 3 3 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_16 PF13432.6 CRG83919.1 - 0.057 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Zn_ribbon_17 PF17120.5 CRG83919.1 - 0.13 12.0 5.1 0.2 11.3 5.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 CRG83919.1 - 0.32 11.3 5.5 0.51 10.7 5.5 1.3 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 CRG83919.1 - 0.51 10.3 6.1 0.97 9.4 6.1 1.5 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 CRG83919.1 - 0.97 9.3 3.9 1.8 8.4 3.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 CRG83919.1 - 4.5 7.5 8.8 8.8 6.5 8.8 1.5 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 CRG83919.1 - 5.6 7.2 6.3 18 5.6 6.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Spc24 PF08286.11 CRG83920.1 - 2.5e-38 130.5 2.3 5.9e-37 126.1 0.1 2.1 2 0 0 2 2 2 1 Spc24 subunit of Ndc80 CLZ PF16526.5 CRG83920.1 - 0.0011 19.2 9.4 0.05 14.0 2.3 2.4 2 0 0 2 2 2 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Prefoldin_2 PF01920.20 CRG83920.1 - 0.016 15.2 2.6 2.2 8.3 0.7 2.3 2 0 0 2 2 2 0 Prefoldin subunit TPR_MLP1_2 PF07926.12 CRG83920.1 - 0.032 14.3 9.5 0.67 10.0 9.6 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4795 PF16043.5 CRG83920.1 - 0.037 13.6 1.9 0.072 12.7 1.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) WXG100 PF06013.12 CRG83920.1 - 0.05 13.8 1.4 1.7 8.9 0.1 2.6 2 1 1 3 3 3 0 Proteins of 100 residues with WXG XhlA PF10779.9 CRG83920.1 - 0.076 13.2 5.1 1.3 9.3 0.9 2.3 2 0 0 2 2 2 0 Haemolysin XhlA SlyX PF04102.12 CRG83920.1 - 0.096 13.3 5.2 0.9 10.2 0.7 2.5 2 1 0 2 2 2 0 SlyX DUF724 PF05266.14 CRG83920.1 - 0.13 12.1 3.9 1.5 8.6 3.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 CRG83920.1 - 0.16 9.9 0.7 0.16 9.8 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.8 CRG83920.1 - 0.39 10.8 8.1 0.15 12.1 2.0 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Wbp11 PF09429.10 CRG83920.1 - 0.42 11.0 4.0 0.46 10.9 2.1 2.0 1 1 1 2 2 2 0 WW domain binding protein 11 GAS PF13851.6 CRG83920.1 - 0.48 9.7 7.9 0.33 10.3 2.0 2.1 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4472 PF14739.6 CRG83920.1 - 0.51 11.1 6.4 2.8 8.7 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 CRG83920.1 - 0.98 9.9 10.9 1.5 9.4 10.9 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DMPK_coil PF08826.10 CRG83920.1 - 1.5 9.0 8.9 9.4 6.4 2.3 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like FlaC_arch PF05377.11 CRG83920.1 - 1.9 9.0 5.6 20 5.6 0.2 2.5 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) HR1 PF02185.16 CRG83920.1 - 8.2 6.6 10.3 10 6.3 1.2 2.4 2 1 0 2 2 2 0 Hr1 repeat adh_short PF00106.25 CRG83922.1 - 2.8e-21 75.9 0.3 4.6e-17 62.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83922.1 - 8.5e-15 54.9 0.0 1.2e-11 44.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83922.1 - 4.3e-05 23.5 0.1 0.00024 21.1 0.1 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CRG83922.1 - 0.11 11.9 0.1 0.23 10.9 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 CRG83923.1 - 6.7e-20 71.2 0.0 1.1e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pkinase PF00069.25 CRG83924.1 - 6.8e-23 81.4 0.0 3.8e-13 49.4 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83924.1 - 1.4e-09 37.7 0.1 1.7e-08 34.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase FeoB_Cyto PF17910.1 CRG83924.1 - 0.0088 16.6 0.1 0.044 14.3 0.0 2.1 3 0 0 3 3 3 1 FeoB cytosolic helical domain SGL PF08450.12 CRG83925.1 - 1.6e-27 96.6 0.1 2.5e-27 96.1 0.1 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CRG83925.1 - 4.8e-07 29.9 0.0 1.6e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 Arylesterase Str_synth PF03088.16 CRG83925.1 - 3.2e-06 27.2 0.0 9.6e-06 25.6 0.0 1.8 1 1 0 1 1 1 1 Strictosidine synthase NHL PF01436.21 CRG83925.1 - 0.0033 17.4 0.2 0.083 13.0 0.0 2.6 2 0 0 2 2 2 1 NHL repeat Ank_2 PF12796.7 CRG83926.1 - 1.1e-21 77.2 0.1 8.8e-12 45.5 0.1 4.0 3 2 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG83926.1 - 2.9e-16 59.3 4.1 1.4e-05 25.3 0.0 5.8 4 1 2 6 6 6 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG83926.1 - 6.6e-15 55.3 1.6 0.00016 22.1 0.0 5.3 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG83926.1 - 2.4e-14 52.0 0.3 0.085 13.5 0.0 6.1 5 1 1 6 6 6 4 Ankyrin repeat Ank PF00023.30 CRG83926.1 - 1.5e-08 34.7 2.1 1.7 9.3 0.0 5.0 4 1 1 5 5 5 3 Ankyrin repeat Toprim_3 PF13362.6 CRG83926.1 - 0.12 12.7 1.0 1.7 9.0 0.0 3.0 4 0 0 4 4 4 0 Toprim domain DUF2034 PF10356.9 CRG83927.1 - 5.4e-38 130.3 0.0 2.4e-23 82.5 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 CRG83927.1 - 1e-05 25.5 0.0 2.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease EAL PF00563.20 CRG83927.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 EAL domain Med21 PF11221.8 CRG83928.1 - 1.6e-52 177.6 8.3 4.6e-52 176.1 8.3 1.6 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 CRG83928.1 - 0.0054 16.8 0.9 0.02 14.9 0.9 2.0 1 1 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 CENP-F_N PF10481.9 CRG83928.1 - 0.014 15.1 0.5 0.02 14.6 0.5 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain CLZ PF16526.5 CRG83928.1 - 0.06 13.7 2.1 1.4 9.3 1.5 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SNF2_N PF00176.23 CRG83929.1 - 8.3e-60 202.3 0.0 1.3e-59 201.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG83929.1 - 3.3e-10 40.3 0.0 1.1e-09 38.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG83929.1 - 1.4e-05 25.0 0.0 2.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG83929.1 - 0.0025 17.8 0.0 0.0057 16.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 CRG83929.1 - 0.012 15.6 3.4 0.02 14.8 3.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain HIRAN PF08797.11 CRG83929.1 - 0.032 14.2 0.0 0.085 12.8 0.0 1.7 1 0 0 1 1 1 0 HIRAN domain PI3_PI4_kinase PF00454.27 CRG83930.1 - 2e-45 155.6 0.0 3.4e-45 154.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase GATA PF00320.27 CRG83931.1 - 5.3e-15 54.7 2.6 5.3e-15 54.7 2.6 2.4 2 0 0 2 2 2 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 CRG83931.1 - 0.022 14.3 0.6 0.047 13.2 0.6 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding Pox_A_type_inc PF04508.12 CRG83931.1 - 0.027 14.3 8.5 0.45 10.5 3.6 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Phosducin PF02114.16 CRG83931.1 - 0.06 12.3 0.6 0.13 11.1 0.3 1.6 2 0 0 2 2 2 0 Phosducin Nodulin-like PF06813.13 CRG83932.1 - 3.9e-24 85.5 3.0 9.1e-24 84.3 3.0 1.6 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 CRG83932.1 - 3.9e-17 62.2 30.8 4.5e-17 62.0 25.6 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Neurensin PF14927.6 CRG83932.1 - 0.0054 16.4 0.6 0.052 13.3 0.0 2.5 3 0 0 3 3 3 1 Neurensin DUF2207 PF09972.9 CRG83932.1 - 4.8 5.8 5.5 0.63 8.7 0.4 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Serinc PF03348.15 CRG83933.1 - 5.6e-160 533.0 10.8 6.4e-160 532.8 10.8 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF21 PF01595.20 CRG83933.1 - 0.12 12.1 0.2 0.12 12.1 0.2 4.0 3 1 1 4 4 4 0 Cyclin M transmembrane N-terminal domain MutL_C PF08676.11 CRG83934.1 - 3e-22 79.0 0.0 9e-22 77.4 0.0 1.9 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 CRG83934.1 - 4.8e-19 68.2 0.0 1.8e-18 66.4 0.0 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CRG83934.1 - 5.8e-11 42.4 0.1 3.5e-10 39.9 0.1 2.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CRG83934.1 - 1.1e-07 32.4 0.3 3.8e-06 27.4 0.0 2.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PI3K_1B_p101 PF10486.9 CRG83934.1 - 0.055 11.3 18.6 0.1 10.4 18.6 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GCN5L1 PF06320.13 CRG83935.1 - 5.3e-22 78.1 4.6 5.3e-22 78.1 4.6 1.7 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) DUF3552 PF12072.8 CRG83935.1 - 0.004 16.6 3.0 0.004 16.6 3.0 2.2 1 1 0 2 2 2 1 Domain of unknown function (DUF3552) DUF16 PF01519.16 CRG83935.1 - 0.49 10.9 4.6 0.14 12.7 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF16 Raftlin PF15250.6 CRG83935.1 - 1 8.1 12.4 2.4 6.8 12.4 1.7 1 1 0 1 1 1 0 Raftlin U1snRNP70_N PF12220.8 CRG83935.1 - 2.1 9.1 6.6 4.6 8.0 1.1 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF1664 PF07889.12 CRG83935.1 - 4.1 7.5 6.3 0.63 10.1 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 CRG83935.1 - 9 5.5 12.7 0.14 11.5 3.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Chitin_synth_2 PF03142.15 CRG83936.1 - 6.3e-226 751.1 0.0 8.9e-226 750.6 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 CRG83936.1 - 1.1e-15 57.5 0.1 1.3e-09 38.0 0.0 3.7 2 2 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 CRG83936.1 - 3.2e-15 55.8 0.1 3.1e-14 52.6 1.1 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 CRG83936.1 - 2.3e-13 50.5 2.1 2.3e-13 50.5 2.1 2.1 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CRG83936.1 - 1.4e-11 44.8 0.0 4.5e-11 43.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Myosin_head PF00063.21 CRG83936.1 - 3.9e-11 41.9 0.0 1.3e-10 40.2 0.0 1.8 2 1 0 2 2 2 1 Myosin head (motor domain) Glyco_transf_21 PF13506.6 CRG83936.1 - 0.00027 20.5 0.0 0.0014 18.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 CRG83936.1 - 0.0028 17.5 0.0 0.13 12.1 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Chitin_synth_2 PF03142.15 CRG83937.1 - 1.7e-245 815.6 1.5 2.6e-245 815.1 1.5 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 CRG83937.1 - 7.1e-70 236.0 0.0 5.4e-69 233.1 0.0 1.9 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 CRG83937.1 - 1e-19 70.4 0.9 8.1e-16 57.9 0.1 3.2 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 CRG83937.1 - 1.2e-15 57.1 0.2 6e-15 54.9 0.4 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 CRG83937.1 - 1.7e-12 47.7 0.1 1.1e-11 45.0 0.1 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CRG83937.1 - 2.6e-10 40.6 3.0 2.6e-10 40.6 3.0 2.3 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CRG83937.1 - 0.00079 19.3 0.0 0.31 10.8 0.0 3.0 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CRG83937.1 - 0.068 12.6 0.3 0.52 9.8 0.3 2.3 1 1 0 1 1 1 0 Glycosyl transferase family 21 AAA_16 PF13191.6 CRG83937.1 - 0.073 13.4 0.1 0.25 11.7 0.1 1.9 2 0 0 2 2 2 0 AAA ATPase domain ADH_zinc_N PF00107.26 CRG83938.1 - 1e-12 48.2 0.0 1.7e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG83938.1 - 7.6e-08 33.5 0.0 1.2e-07 32.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG83938.1 - 1.3e-05 25.1 0.2 3.2e-05 23.8 0.1 1.7 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain KH_1 PF00013.29 CRG83939.1 - 8.2e-32 108.8 0.2 9.3e-07 28.6 0.1 7.0 7 0 0 7 7 7 4 KH domain SUV3_C PF12513.8 CRG83939.1 - 0.16 11.9 0.0 0.43 10.5 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal MerR_1 PF13411.6 CRG83940.1 - 0.0092 16.0 0.3 0.023 14.8 0.3 1.7 1 0 0 1 1 1 1 MerR HTH family regulatory protein Dynactin PF12455.8 CRG83941.1 - 2.8e-97 325.4 6.7 2.8e-97 325.4 6.7 4.3 4 1 0 3 3 3 1 Dynein associated protein CAP_GLY PF01302.25 CRG83941.1 - 2.6e-23 81.8 0.1 5.1e-23 80.9 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain HAD_2 PF13419.6 CRG83941.1 - 2.9e-07 30.7 0.1 2.9e-07 30.7 0.1 4.2 4 1 0 4 4 4 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG83941.1 - 5.7e-07 30.0 2.6 3.9e-06 27.3 0.0 3.7 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF2353 PF09789.9 CRG83941.1 - 0.00017 21.0 27.1 0.00017 21.0 27.1 4.0 2 1 1 3 3 3 2 Uncharacterized coiled-coil protein (DUF2353) EzrA PF06160.12 CRG83941.1 - 0.44 8.7 77.8 0.13 10.4 21.0 4.5 2 1 2 4 4 4 0 Septation ring formation regulator, EzrA Solute_trans_a PF03619.16 CRG83943.1 - 3.6e-96 321.8 11.5 5.2e-96 321.2 11.5 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Amastin PF07344.11 CRG83943.1 - 2.2 8.1 5.6 18 5.2 5.6 2.1 1 1 0 1 1 1 0 Amastin surface glycoprotein GTP_EFTU PF00009.27 CRG83945.1 - 3.3e-67 225.8 0.3 5.7e-67 225.0 0.3 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 CRG83945.1 - 6.7e-32 109.8 0.0 2e-31 108.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CRG83945.1 - 6.3e-22 77.4 0.0 1.6e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CRG83945.1 - 1.6e-12 47.3 0.1 6.7e-12 45.3 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CRG83945.1 - 5.8e-12 45.8 0.1 7.6e-11 42.3 0.0 2.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PWI PF01480.17 CRG83945.1 - 3.4e-10 40.1 0.1 7.9e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 CRG83945.1 - 5.3e-09 35.8 0.5 3.5e-07 30.0 0.1 3.4 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG83945.1 - 0.00012 22.0 0.0 0.003 17.5 0.0 2.6 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif MMR_HSR1 PF01926.23 CRG83945.1 - 0.0015 18.6 0.9 0.0032 17.5 0.2 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF1866 PF08952.11 CRG83945.1 - 0.0015 18.4 0.0 0.0047 16.8 0.0 1.8 2 0 0 2 2 1 1 Domain of unknown function (DUF1866) zf-CCCH PF00642.24 CRG83945.1 - 0.014 15.3 2.7 0.026 14.4 2.7 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_5 PF13893.6 CRG83945.1 - 0.043 13.4 0.0 0.091 12.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.6 CRG83945.1 - 0.044 13.3 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) zf-CCCH_4 PF18044.1 CRG83945.1 - 0.12 12.2 1.7 0.21 11.4 1.7 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Whi5 PF08528.11 CRG83946.1 - 0.0043 16.6 0.7 0.0083 15.7 0.7 1.5 1 0 0 1 1 1 1 Whi5 like RIBIOP_C PF04950.12 CRG83947.1 - 1e-94 317.2 0.0 1e-94 317.2 0.0 1.5 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CRG83947.1 - 3e-28 97.7 0.0 9.4e-28 96.1 0.0 1.9 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GRDP-like PF07173.12 CRG83947.1 - 1.1e-15 58.5 9.6 4.6e-12 46.8 0.2 3.4 4 0 0 4 4 2 2 Glycine-rich domain-containing protein-like AAA_22 PF13401.6 CRG83947.1 - 2.5e-05 24.6 0.8 0.00017 21.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CRG83947.1 - 0.00011 22.4 0.0 0.0004 20.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 CRG83947.1 - 0.00066 19.3 0.0 0.065 12.8 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 CRG83947.1 - 0.00075 19.9 0.0 0.002 18.6 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG83947.1 - 0.0008 19.8 0.0 0.0022 18.4 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 CRG83947.1 - 0.004 17.2 0.0 0.012 15.7 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.22 CRG83947.1 - 0.0047 16.2 0.0 0.0086 15.3 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 CRG83947.1 - 0.0083 16.5 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Wzy_C_2 PF11846.8 CRG83947.1 - 0.012 15.5 1.0 0.023 14.6 1.0 1.4 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal AAA_18 PF13238.6 CRG83947.1 - 0.013 16.1 4.4 0.021 15.4 0.2 3.2 3 0 0 3 3 2 0 AAA domain NACHT PF05729.12 CRG83947.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 CRG83947.1 - 0.013 15.5 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 CRG83947.1 - 0.017 14.6 0.0 0.042 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 CRG83947.1 - 0.022 14.5 0.1 0.2 11.4 0.1 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 CRG83947.1 - 0.023 15.2 1.3 0.064 13.8 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_30 PF13604.6 CRG83947.1 - 0.034 13.9 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CRG83947.1 - 0.053 13.4 0.0 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 CRG83947.1 - 0.054 13.1 0.2 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 CRG83947.1 - 0.062 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 CRG83947.1 - 0.079 12.9 0.3 0.16 11.9 0.3 1.4 1 0 0 1 1 1 0 NTPase Roc PF08477.13 CRG83947.1 - 0.086 13.1 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 CRG83947.1 - 0.098 12.7 0.2 0.37 10.8 0.1 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 CRG83947.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_17 PF13207.6 CRG83947.1 - 0.1 13.0 0.1 0.1 13.0 0.1 2.4 2 0 0 2 2 1 0 AAA domain KAP_NTPase PF07693.14 CRG83947.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain SRP54 PF00448.22 CRG83947.1 - 0.14 11.8 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATP_bind_1 PF03029.17 CRG83947.1 - 0.2 11.4 0.1 0.37 10.5 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein ATPase_2 PF01637.18 CRG83947.1 - 0.21 11.5 0.0 0.21 11.5 0.0 1.9 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea Lon_C PF05362.13 CRG83948.1 - 1.4e-69 233.8 0.1 3.1e-69 232.6 0.1 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CRG83948.1 - 2.3e-31 109.3 0.3 4.6e-31 108.3 0.3 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CRG83948.1 - 1.9e-23 83.3 0.0 6.1e-23 81.7 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CRG83948.1 - 7.3e-08 32.5 0.0 2.9e-07 30.6 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 CRG83948.1 - 2.3e-06 27.4 0.0 5.9e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 CRG83948.1 - 8.2e-06 26.3 0.7 5.7e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 CRG83948.1 - 0.00012 21.8 0.0 0.00037 20.3 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 CRG83948.1 - 0.00021 21.2 0.0 0.00073 19.4 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CRG83948.1 - 0.00022 21.0 0.1 0.0009 19.0 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CRG83948.1 - 0.0003 21.1 0.1 0.0049 17.1 0.0 3.0 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 CRG83948.1 - 0.0014 17.9 0.1 0.0039 16.5 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_33 PF13671.6 CRG83948.1 - 0.0017 18.5 0.0 0.0057 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CRG83948.1 - 0.0045 17.1 0.0 0.015 15.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 CRG83948.1 - 0.0065 15.9 0.0 0.015 14.8 0.0 1.5 1 0 0 1 1 1 1 PhoH-like protein AAA_7 PF12775.7 CRG83948.1 - 0.018 14.6 0.0 0.034 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 CRG83948.1 - 0.018 15.1 0.0 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CRG83948.1 - 0.021 14.4 0.0 0.056 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CRG83948.1 - 0.029 14.9 0.0 0.073 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CRG83948.1 - 0.031 14.2 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_11 PF13086.6 CRG83948.1 - 0.037 13.8 0.8 0.086 12.6 0.0 1.9 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 CRG83948.1 - 0.038 13.4 0.1 0.093 12.1 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 CRG83948.1 - 0.041 14.2 1.1 0.25 11.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG83948.1 - 0.064 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_PrkA PF08298.11 CRG83948.1 - 0.08 11.8 0.1 0.58 9.0 0.1 2.1 2 0 0 2 2 2 0 PrkA AAA domain TniB PF05621.11 CRG83948.1 - 0.08 12.3 0.0 0.31 10.4 0.0 2.0 1 0 0 1 1 1 0 Bacterial TniB protein AAA_30 PF13604.6 CRG83948.1 - 0.09 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CRG83948.1 - 0.093 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SOAR PF16533.5 CRG83948.1 - 0.098 12.6 0.2 0.34 10.9 0.2 1.9 1 0 0 1 1 1 0 STIM1 Orai1-activating region NACHT PF05729.12 CRG83948.1 - 0.13 12.2 0.0 0.56 10.1 0.0 2.1 1 0 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 CRG83948.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain LPD1 PF18796.1 CRG83948.1 - 0.16 12.1 0.1 0.4 10.8 0.1 1.7 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 1 AAA_23 PF13476.6 CRG83948.1 - 0.89 10.0 0.0 0.89 10.0 0.0 2.8 1 1 1 2 2 1 0 AAA domain Ribosomal_L23 PF00276.20 CRG83949.1 - 1.6e-10 41.2 0.0 4e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L23 RIO1 PF01163.22 CRG83950.1 - 5.2e-41 140.3 0.1 1e-28 100.3 0.0 2.3 2 0 0 2 2 2 2 RIO1 family Rio2_N PF09202.11 CRG83950.1 - 1.5e-32 111.7 0.0 3.5e-32 110.5 0.0 1.6 2 0 0 2 2 2 1 Rio2, N-terminal Kdo PF06293.14 CRG83950.1 - 2.5e-08 33.6 0.0 1.9e-06 27.4 0.0 2.3 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG83950.1 - 1.1e-06 28.8 0.0 0.024 14.6 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family CobT PF06213.12 CRG83950.1 - 0.76 9.1 15.1 1.2 8.4 15.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 CRG83950.1 - 1 8.6 12.7 1.5 8.1 12.7 1.2 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 CRG83950.1 - 1.7 8.4 9.2 2.8 7.7 9.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RPN1_RPN2_N PF17781.1 CRG83951.1 - 5.7e-118 393.8 7.0 9.6e-118 393.1 7.0 1.4 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 CRG83951.1 - 1.6e-29 101.7 0.0 2.9e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 CRG83951.1 - 3.7e-16 58.6 15.9 0.00036 20.8 0.1 7.6 8 0 0 8 8 8 4 Proteasome/cyclosome repeat AbbA_antirepres PF14156.6 CRG83951.1 - 0.051 13.5 0.7 0.36 10.7 0.1 2.9 2 0 0 2 2 2 0 Antirepressor AbbA TPR_12 PF13424.6 CRG83951.1 - 0.22 11.8 1.7 6 7.2 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Mlh1_C PF16413.5 CRG83953.1 - 2.4e-99 332.1 0.0 6.8e-99 330.6 0.0 1.7 2 0 0 2 2 2 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 CRG83953.1 - 1.4e-32 111.8 0.2 2.3e-32 111.1 0.2 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 CRG83953.1 - 3.4e-14 52.8 0.0 7.4e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CRG83953.1 - 7.6e-08 32.8 0.0 3.2e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF5540 PF17694.1 CRG83953.1 - 0.13 12.8 0.0 0.31 11.6 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5540) DSPc PF00782.20 CRG83954.1 - 2e-27 95.6 0.0 2.7e-20 72.6 0.0 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CRG83954.1 - 4.1e-05 23.3 0.0 0.0031 17.1 0.0 2.3 2 0 0 2 2 2 2 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 CRG83954.1 - 0.0083 16.3 0.1 0.53 10.4 0.1 2.5 2 0 0 2 2 2 1 Inositol hexakisphosphate Cupin_8 PF13621.6 CRG83955.1 - 5.4e-42 144.3 0.0 9.5e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain LCM PF04072.14 CRG83955.1 - 1.2e-19 71.0 0.0 1.9e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 CRG83955.1 - 1.6e-06 28.0 5.4 0.043 13.8 0.1 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Cupin_4 PF08007.12 CRG83955.1 - 1.8e-06 27.6 0.0 7.7e-06 25.6 0.0 1.8 2 1 0 2 2 2 1 Cupin superfamily protein Kelch_5 PF13854.6 CRG83955.1 - 4e-06 26.7 2.5 0.063 13.3 0.0 4.1 4 0 0 4 4 4 2 Kelch motif ANAPC4_WD40 PF12894.7 CRG83956.1 - 0.00032 20.9 0.0 1.6 9.1 0.0 4.0 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG83956.1 - 0.0017 19.1 0.2 0.095 13.6 0.0 3.5 3 1 1 4 4 4 1 WD domain, G-beta repeat CNH PF00780.22 CRG83956.1 - 0.0023 17.6 0.0 0.56 9.8 0.1 2.9 2 1 0 2 2 2 2 CNH domain Coatomer_WDAD PF04053.14 CRG83956.1 - 0.004 16.2 0.0 0.03 13.4 0.0 2.2 3 0 0 3 3 3 1 Coatomer WD associated region MMS1_N PF10433.9 CRG83956.1 - 0.049 12.3 0.1 1.6 7.3 0.0 2.6 3 0 0 3 3 3 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Hira PF07569.11 CRG83956.1 - 0.11 12.2 0.0 0.79 9.4 0.0 2.3 3 0 0 3 3 3 0 TUP1-like enhancer of split DUF3337 PF11816.8 CRG83957.1 - 1.1e-54 184.8 0.0 2.6e-54 183.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) WD40 PF00400.32 CRG83957.1 - 3.7e-17 62.4 19.2 0.003 18.4 0.0 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 CRG83957.1 - 0.0012 17.6 3.9 0.13 10.8 0.1 2.6 3 0 0 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CRG83957.1 - 0.014 15.7 0.4 0.5 10.7 0.1 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG83957.1 - 0.1 11.5 0.0 1.2 8.0 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein APP_N PF02177.16 CRG83957.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 Amyloid A4 N-terminal heparin-binding ATP_bind_3 PF01171.20 CRG83958.1 - 2e-40 138.5 0.0 3.6e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 PP-loop family adh_short PF00106.25 CRG83960.1 - 5.3e-14 52.1 0.0 6e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG83960.1 - 1.8e-07 31.0 0.0 2.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG83960.1 - 0.00022 21.2 0.0 0.00026 21.0 0.0 1.0 1 0 0 1 1 1 1 KR domain RhoGEF PF00621.20 CRG83961.1 - 9.7e-22 78.1 1.0 4.8e-21 75.8 0.1 2.3 2 0 0 2 2 2 1 RhoGEF domain DUF3507 PF12015.8 CRG83961.1 - 7.6e-07 29.0 0.0 1.5e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Nod1 PF17114.5 CRG83961.1 - 0.00022 21.4 0.0 0.00096 19.3 0.0 2.2 1 0 0 1 1 1 1 Gef2-related medial cortical node protein Nod1 Sec7 PF01369.20 CRG83962.1 - 6.9e-63 211.6 0.0 1.1e-62 210.9 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CRG83962.1 - 9.9e-17 61.3 0.1 1.3e-15 57.6 0.0 2.8 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_14 PF13428.6 CRG83963.1 - 4.6e-13 48.8 20.5 0.14 13.1 0.0 11.6 9 3 5 14 14 13 3 Tetratricopeptide repeat Suf PF05843.14 CRG83963.1 - 8.3e-13 49.0 8.9 0.013 15.5 0.1 5.6 3 1 3 6 6 6 5 Suppressor of forked protein (Suf) TPR_8 PF13181.6 CRG83963.1 - 4.4e-09 35.8 2.2 0.13 12.5 0.0 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 CRG83963.1 - 9e-09 35.7 0.2 1.1 9.8 0.0 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG83963.1 - 6.1e-08 32.9 3.4 0.31 11.3 0.0 7.4 6 1 0 6 6 6 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 CRG83963.1 - 5.6e-06 26.3 12.7 0.76 9.8 0.2 7.5 5 3 2 7 7 7 2 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 CRG83963.1 - 5.2e-05 23.1 17.1 1.1 9.6 0.0 7.7 9 0 0 9 9 8 2 Tetratricopeptide repeat HAT PF02184.16 CRG83963.1 - 0.00028 20.8 1.0 2.8 8.0 0.0 5.4 5 0 0 5 5 4 1 HAT (Half-A-TPR) repeat TPR_17 PF13431.6 CRG83963.1 - 0.01 16.2 3.9 2.6 8.6 0.1 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 CRG83963.1 - 0.021 14.7 0.1 48 4.0 0.0 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat NRDE-2 PF08424.10 CRG83963.1 - 0.028 13.5 12.6 0.072 12.2 0.6 5.8 2 2 0 3 3 3 0 NRDE-2, necessary for RNA interference MIT PF04212.18 CRG83963.1 - 0.07 13.2 0.1 6.2 7.0 0.0 3.8 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain AsiA PF09010.10 CRG83963.1 - 0.12 12.5 0.0 5.5 7.2 0.0 2.6 2 0 0 2 2 2 0 Anti-Sigma Factor A TPR_10 PF13374.6 CRG83963.1 - 0.59 10.1 5.8 1.3e+02 2.7 0.4 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat PPR PF01535.20 CRG83963.1 - 1.6 9.1 5.5 61 4.2 0.0 4.9 6 0 0 6 6 6 0 PPR repeat ATP-synt_D PF01813.17 CRG83964.1 - 5.2e-68 228.8 3.0 6.5e-68 228.4 3.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit D DUF3919 PF13057.6 CRG83964.1 - 0.056 13.0 0.9 0.084 12.4 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) HtrL_YibB PF09612.10 CRG83964.1 - 0.056 13.0 0.2 0.082 12.4 0.2 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) CobA_CobO_BtuR PF02572.15 CRG83964.1 - 0.14 12.4 2.1 0.58 10.4 0.1 2.3 2 1 1 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Ribosomal_L6e PF01159.19 CRG83964.1 - 0.14 12.7 2.9 0.54 10.8 2.9 1.9 1 0 0 1 1 1 0 Ribosomal protein L6e DUF5446 PF17522.2 CRG83964.1 - 0.49 10.6 2.3 0.8 9.9 0.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5446) HAUS6_N PF14661.6 CRG83964.1 - 0.95 9.0 5.7 3.7 7.1 2.4 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus RRM_1 PF00076.22 CRG83965.1 - 5.3e-27 93.4 0.5 4.5e-13 48.8 0.4 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG83965.1 - 7.7e-07 28.7 0.0 2.5e-05 23.8 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG83965.1 - 0.00014 21.7 0.0 0.055 13.3 0.0 2.3 2 0 0 2 2 2 2 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CRG83965.1 - 0.0063 16.6 0.0 0.015 15.3 0.0 1.7 1 0 0 1 1 1 1 Limkain b1 DUF4523 PF15023.6 CRG83965.1 - 0.025 14.4 0.0 0.1 12.4 0.0 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4523) RRM_7 PF16367.5 CRG83965.1 - 0.061 13.5 0.1 8.7 6.5 0.0 2.7 2 1 0 2 2 2 0 RNA recognition motif PHM7_cyt PF14703.6 CRG83965.1 - 0.17 12.1 1.7 4.8 7.4 0.1 3.1 3 2 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter TFCD_C PF12612.8 CRG83967.1 - 1.4e-36 126.1 1.2 4.1e-36 124.6 0.7 2.1 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT PF02985.22 CRG83967.1 - 1.1e-07 31.5 9.9 0.49 10.8 0.1 7.8 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 CRG83967.1 - 2.4e-06 27.8 3.6 3.4 8.1 0.0 6.1 5 1 1 6 6 6 2 HEAT repeats IFRD PF05004.13 CRG83967.1 - 0.00019 20.6 1.0 0.00019 20.6 1.0 3.0 3 2 1 4 4 4 1 Interferon-related developmental regulator (IFRD) TetR_C_28 PF17937.1 CRG83967.1 - 0.096 13.1 0.8 5.9 7.4 0.1 3.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HEAT_EZ PF13513.6 CRG83967.1 - 0.24 12.0 22.6 18 6.0 0.2 8.9 11 0 0 11 11 11 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CRG83967.1 - 0.53 10.9 2.6 12 6.5 0.0 4.0 6 0 0 6 6 6 0 Vacuolar 14 Fab1-binding region TAN PF11640.8 CRG83967.1 - 0.8 9.8 5.3 0.21 11.7 0.3 2.7 3 0 0 3 3 3 0 Telomere-length maintenance and DNA damage repair HEAT_PBS PF03130.16 CRG83967.1 - 4.9 8.1 0.0 4.9 8.1 0.0 3.9 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Pkinase PF00069.25 CRG83969.1 - 3.2e-59 200.4 0.0 5.6e-59 199.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG83969.1 - 1.1e-35 123.2 0.0 1.8e-35 122.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 CRG83969.1 - 1.5e-29 101.9 13.3 2.8e-15 56.2 4.5 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 CRG83969.1 - 1.8e-20 72.5 29.0 4.3e-12 45.7 9.3 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 CRG83969.1 - 7.8e-14 52.1 1.1 3e-13 50.3 1.1 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 CRG83969.1 - 7.5e-07 29.4 0.0 1.4e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 CRG83969.1 - 0.14 11.5 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Uds1 PF15456.6 CRG83969.1 - 2.2 8.5 5.7 1.1 9.4 0.6 2.5 2 0 0 2 2 2 0 Up-regulated During Septation MFS_1 PF07690.16 CRG83970.1 - 8.6e-32 110.4 69.5 1.8e-26 92.9 43.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG83970.1 - 0.00018 20.2 21.1 0.0023 16.6 5.2 2.3 1 1 0 2 2 2 2 MFS/sugar transport protein eIF-1a PF01176.19 CRG83971.1 - 6.8e-20 70.6 0.1 9.1e-20 70.2 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 CSD2 PF17876.1 CRG83971.1 - 0.079 13.1 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Cold shock domain ALG3 PF05208.13 CRG83972.1 - 1.2e-139 465.7 9.0 1.4e-139 465.5 9.0 1.0 1 0 0 1 1 1 1 ALG3 protein COA2 PF17051.5 CRG83973.1 - 0.0068 16.4 0.0 0.0099 15.9 0.0 1.4 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Metallophos PF00149.28 CRG83974.1 - 6.1e-31 108.5 0.0 4.3e-22 79.6 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CRG83974.1 - 0.13 12.8 0.1 0.33 11.4 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Fungal_trans PF04082.18 CRG83977.1 - 3.9e-45 154.0 0.1 7.9e-45 153.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG83977.1 - 6.9e-08 32.5 8.3 1.6e-07 31.3 8.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHD PF00628.29 CRG83977.1 - 0.0024 17.7 4.4 0.0065 16.3 4.4 1.8 1 0 0 1 1 1 1 PHD-finger HypA PF01155.19 CRG83977.1 - 1.9 8.6 0.0 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Methyltransf_2 PF00891.18 CRG83980.1 - 2.5e-28 98.8 0.0 4.2e-28 98.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CRG83980.1 - 2e-05 25.2 0.0 5e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG83980.1 - 0.0001 23.0 0.0 0.00025 21.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG83980.1 - 0.00071 20.2 0.0 0.0016 19.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG83980.1 - 0.0022 17.8 0.0 0.0036 17.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 CRG83980.1 - 0.0047 16.5 0.0 0.0084 15.7 0.0 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 CRG83980.1 - 0.0048 16.7 0.0 0.0091 15.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CRG83980.1 - 0.0054 16.6 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG83980.1 - 0.0078 15.8 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CRG83980.1 - 0.017 14.9 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AMP-binding PF00501.28 CRG83981.1 - 4.9e-55 186.8 0.0 6.6e-55 186.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.20 CRG83981.1 - 1.2e-27 97.5 0.0 3.9e-27 95.8 0.0 1.9 1 1 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 CRG83981.1 - 4.5e-14 52.6 0.2 1.2e-13 51.2 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_1 PF00561.20 CRG83981.1 - 0.017 14.8 0.0 0.032 13.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG83981.1 - 0.028 15.0 0.0 0.049 14.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family CCDC-167 PF15188.6 CRG83981.1 - 0.12 12.8 0.1 0.29 11.5 0.1 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Methyltransf_2 PF00891.18 CRG83982.1 - 2e-20 73.0 0.0 2.7e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CRG83982.1 - 0.0051 16.8 0.3 0.017 15.1 0.2 1.9 2 0 0 2 2 2 1 Dimerisation domain Ribosomal_L18p PF00861.22 CRG83982.1 - 0.053 13.9 0.0 0.093 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Dimerisation PF08100.11 CRG83982.1 - 0.058 13.4 0.1 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 Dimerisation domain DNA_ligase_A_M PF01068.21 CRG83984.1 - 9.6e-48 162.5 0.3 6.8e-47 159.7 0.0 2.4 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CRG83984.1 - 3.6e-46 157.6 0.0 1.2e-44 152.6 0.0 2.5 2 0 0 2 2 2 1 DNA ligase N terminus RNA_ligase PF09414.10 CRG83984.1 - 4.1e-18 66.2 0.0 8.1e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 RNA ligase DNA_ligase_A_C PF04679.15 CRG83984.1 - 7.2e-18 65.0 0.0 4.6e-16 59.2 0.0 3.0 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 CRG83984.1 - 1.9e-16 60.2 0.1 1e-12 48.3 0.1 2.8 3 0 0 3 3 3 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CRG83984.1 - 5.5e-07 29.9 0.2 5.4e-06 26.7 0.1 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.8 CRG83984.1 - 0.00013 22.0 0.1 0.00028 20.9 0.1 1.6 1 0 0 1 1 1 1 DNA ligase IV LIG3_BRCT PF16759.5 CRG83984.1 - 0.0027 17.9 1.5 0.039 14.3 0.0 2.7 2 1 0 2 2 2 1 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 CRG83984.1 - 0.014 15.3 0.3 1.2 9.1 0.1 2.5 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain Fungal_trans PF04082.18 CRG83985.1 - 1.5e-19 70.1 2.4 2.8e-19 69.2 2.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain EF-hand_4 PF12763.7 CRG83986.1 - 0.0044 16.9 0.0 0.0086 16.0 0.0 1.4 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Fungal_trans PF04082.18 CRG83987.1 - 0.22 10.5 5.1 0.11 11.5 1.9 2.2 2 1 0 2 2 2 0 Fungal specific transcription factor domain Spb1_C PF07780.12 CRG83989.1 - 2.3e-85 285.5 22.7 2.3e-85 285.5 22.7 3.2 2 1 1 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 CRG83989.1 - 5.2e-57 192.8 0.1 1.3e-56 191.6 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 CRG83989.1 - 1.5e-50 171.2 12.3 1.5e-50 171.2 12.3 4.7 4 1 2 6 6 6 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 CRG83989.1 - 0.032 14.1 0.0 0.089 12.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain DOT1 PF08123.13 CRG83990.1 - 1.9e-76 256.1 0.0 2.6e-76 255.7 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 ATG16 PF08614.11 CRG83991.1 - 2e-55 188.1 28.5 2e-55 188.1 28.5 1.8 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) HTH_7 PF02796.15 CRG83991.1 - 0.00041 20.3 0.1 0.001 19.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_32 PF13565.6 CRG83991.1 - 0.00044 20.8 0.8 0.00044 20.8 0.8 4.4 2 1 3 5 5 5 1 Homeodomain-like domain BST2 PF16716.5 CRG83991.1 - 0.76 10.4 17.5 0.065 13.8 5.2 3.4 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 GrpE PF01025.19 CRG83991.1 - 3.5 7.3 13.6 0.038 13.7 2.2 2.7 3 0 0 3 3 3 0 GrpE BRE1 PF08647.11 CRG83991.1 - 3.5 7.8 20.9 0.17 12.0 9.8 3.2 3 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase IFT57 PF10498.9 CRG83991.1 - 3.5 6.5 14.9 6.1 5.7 13.2 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF4201 PF13870.6 CRG83991.1 - 4 7.2 21.7 0.022 14.5 11.4 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) FlaC_arch PF05377.11 CRG83991.1 - 5.2 7.5 5.2 20 5.7 0.4 3.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Fungal_trans PF04082.18 CRG83993.1 - 1.1e-18 67.2 0.1 2.4e-18 66.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ras PF00071.22 CRG83995.1 - 3.8e-56 189.1 0.1 4.7e-56 188.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG83995.1 - 7.1e-32 110.1 0.0 1e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG83995.1 - 2.1e-12 46.9 0.0 2.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CRG83995.1 - 1.9e-07 31.1 0.0 3.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CRG83995.1 - 5.2e-06 26.0 0.0 6.7e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CRG83995.1 - 2.6e-05 23.8 0.0 0.00078 19.0 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CRG83995.1 - 0.00046 20.1 0.3 0.0057 16.6 0.1 2.3 1 1 2 3 3 3 1 RsgA GTPase ATP_bind_1 PF03029.17 CRG83995.1 - 0.0033 17.3 0.2 0.068 12.9 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 CRG83995.1 - 0.0039 16.9 0.1 0.19 11.5 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 CRG83995.1 - 0.0098 15.2 0.1 0.1 11.9 0.0 2.1 2 0 0 2 2 2 1 Septin cobW PF02492.19 CRG83995.1 - 0.012 15.2 0.0 0.042 13.4 0.0 1.7 1 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CRG83995.1 - 0.016 15.5 0.0 0.03 14.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 CRG83995.1 - 0.017 14.5 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_5 PF07728.14 CRG83995.1 - 0.018 15.1 0.0 0.036 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG83995.1 - 0.018 15.4 0.0 0.051 14.0 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CRG83995.1 - 0.032 13.7 0.0 0.053 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 CRG83995.1 - 0.035 13.8 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CRG83995.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 CRG83995.1 - 0.15 11.4 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RuvB_N PF05496.12 CRG83995.1 - 0.16 11.7 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain EamA PF00892.20 CRG83996.1 - 1.5e-12 47.9 39.2 2.8e-07 30.8 3.6 3.1 3 0 0 3 3 3 3 EamA-like transporter family DUF3955 PF13127.6 CRG83996.1 - 0.00017 21.3 2.9 0.00017 21.3 2.9 3.4 5 0 0 5 5 5 1 Protein of unknown function (DUF3955) UAA PF08449.11 CRG83996.1 - 0.0002 20.6 6.4 0.0002 20.6 6.4 1.9 2 0 0 2 2 2 1 UAA transporter family PUNUT PF16913.5 CRG83996.1 - 0.00029 20.2 2.5 0.00029 20.2 2.5 2.8 3 0 0 3 3 3 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 CRG83996.1 - 0.0009 18.8 6.2 0.0009 18.8 6.2 2.8 2 1 1 3 3 3 1 Solute carrier family 35 PH PF00169.29 CRG83997.1 - 8.1e-25 87.4 0.4 2.2e-11 44.2 0.0 2.2 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 CRG83997.1 - 1.3e-07 32.0 0.9 0.00097 19.5 0.1 3.3 2 2 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 CRG83997.1 - 1.9e-07 31.5 0.2 0.15 12.4 0.0 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain BCL_N PF04714.13 CRG83997.1 - 0.066 13.3 0.2 0.15 12.2 0.2 1.5 1 0 0 1 1 1 0 BCL7, N-terminal conserver region Glyco_transf_15 PF01793.16 CRG83999.1 - 3.6e-95 318.9 10.1 9.9e-95 317.5 10.1 1.6 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase OPT PF03169.15 CRG84000.1 - 3.8e-173 577.4 54.8 4.3e-173 577.3 54.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein p450 PF00067.22 CRG84001.1 - 1e-51 176.1 0.0 1.5e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 His_Phos_1 PF00300.22 CRG84004.1 - 4e-16 59.3 0.0 8.3e-09 35.4 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF1248 PF06852.12 CRG84004.1 - 0.011 15.2 0.0 0.08 12.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1248) HECT PF00632.25 CRG84005.1 - 7.1e-71 239.2 0.0 1.3e-70 238.3 0.0 1.5 1 1 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 CRG84005.1 - 8.1e-22 77.2 2.7 2.7e-21 75.6 2.7 2.0 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zf-C2H2_2 PF12756.7 CRG84006.1 - 1e-38 131.7 7.9 1.9e-31 108.4 1.2 3.4 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 CRG84006.1 - 2.8e-07 30.6 17.0 7.1e-07 29.4 6.8 4.0 3 1 1 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG84006.1 - 6.9e-07 29.4 4.7 6.9e-07 29.4 4.7 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type Cytochrome-c551 PF10643.9 CRG84006.1 - 0.0022 17.6 0.7 0.46 10.0 0.1 2.4 2 0 0 2 2 2 2 Photosystem P840 reaction-centre cytochrome c-551 zf-C2H2_4 PF13894.6 CRG84006.1 - 0.017 15.9 12.7 1.1 10.3 0.6 4.5 4 0 0 4 4 4 0 C2H2-type zinc finger Phage_sheath_1C PF17482.2 CRG84006.1 - 0.031 14.2 0.2 0.081 12.9 0.0 1.8 2 0 0 2 2 2 0 Phage tail sheath C-terminal domain zf-C2H2 PF00096.26 CRG84006.1 - 1.3 9.6 14.6 2.2 8.9 1.9 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-LYAR PF08790.11 CRG84006.1 - 1.6 8.7 12.5 0.17 11.8 2.4 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DUF21 PF01595.20 CRG84007.1 - 2.1e-33 115.5 0.1 3.5e-33 114.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 CRG84007.1 - 6.7e-06 26.5 0.6 0.041 14.3 0.1 2.9 2 0 0 2 2 2 2 CBS domain Transket_pyr PF02779.24 CRG84009.1 - 6.4e-42 143.2 0.1 1.2e-41 142.3 0.1 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CRG84009.1 - 2.3e-31 108.2 0.0 4.9e-31 107.2 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 CRG84009.1 - 0.1 12.9 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Fez1 PF06818.15 CRG84011.1 - 0.0018 18.8 18.1 0.0018 18.8 18.1 3.0 1 1 2 3 3 3 1 Fez1 DUF4250 PF14056.6 CRG84011.1 - 0.073 13.0 0.2 0.073 13.0 0.2 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4250) ATG16 PF08614.11 CRG84011.1 - 0.63 10.2 59.6 2.7 8.2 20.3 3.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Tropomyosin PF00261.20 CRG84011.1 - 0.98 8.7 35.1 0.089 12.1 10.5 3.2 2 1 1 3 3 3 0 Tropomyosin DUF4200 PF13863.6 CRG84011.1 - 8.7 6.8 37.5 0.93 9.9 11.8 3.9 3 1 0 4 4 4 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 CRG84011.1 - 9.4 6.3 18.2 0.4 10.7 4.2 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) KCH PF16944.5 CRG84012.1 - 1.2e-104 349.6 10.4 1.4e-104 349.3 10.4 1.1 1 0 0 1 1 1 1 Fungal potassium channel Fzo_mitofusin PF04799.13 CRG84012.1 - 0.19 11.2 0.1 0.33 10.5 0.1 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF4381 PF14316.6 CRG84012.1 - 0.79 10.0 2.3 1.7 8.9 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Glyoxalase PF00903.25 CRG84013.1 - 1.2e-22 80.5 0.9 1.4e-15 57.7 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CRG84013.1 - 3e-11 43.5 0.2 0.00013 22.2 0.0 2.5 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 CRG84013.1 - 6e-05 23.2 0.5 0.51 10.4 0.5 3.0 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 CRG84013.1 - 0.00025 21.3 0.4 0.041 14.1 0.1 2.3 1 1 1 2 2 2 2 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DUF4844 PF16133.5 CRG84013.1 - 0.12 12.9 0.0 0.37 11.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) HgmA PF04209.13 CRG84014.1 - 1.3e-209 696.2 0.2 1.5e-209 696.0 0.2 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase TPR_17 PF13431.6 CRG84015.1 - 0.22 12.0 0.9 3 8.4 0.2 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat FAA_hydrolase PF01557.18 CRG84016.1 - 1.3e-55 188.5 0.0 1.8e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CRG84016.1 - 1.4e-31 108.8 0.0 2.5e-31 108.0 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal GST_N_2 PF13409.6 CRG84017.1 - 2.4e-12 46.9 0.1 4.9e-11 42.8 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG84017.1 - 1.7e-08 34.7 0.0 2.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CRG84017.1 - 1.9e-08 34.6 0.1 3.5e-08 33.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG84017.1 - 3.2e-07 30.5 0.0 6.4e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG84017.1 - 8.8e-06 25.8 0.0 1.8e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG84017.1 - 0.0027 17.7 0.2 0.0058 16.6 0.2 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 CRG84017.1 - 0.039 14.2 0.0 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 Glutaredoxin Glyco_hydro_92 PF07971.12 CRG84018.1 - 2.5e-148 494.9 3.7 3e-148 494.6 3.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CRG84018.1 - 6.8e-62 209.5 0.2 1.1e-61 208.7 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Gln-synt_N PF03951.19 CRG84018.1 - 0.002 17.8 0.1 0.041 13.6 0.0 2.6 1 1 1 2 2 2 1 Glutamine synthetase, beta-Grasp domain Zn_clus PF00172.18 CRG84019.1 - 6.2e-06 26.2 11.3 1.1e-05 25.5 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF747 PF05346.11 CRG84020.1 - 7.3e-120 400.2 9.4 1e-119 399.8 9.4 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF4834 PF16118.5 CRG84020.1 - 1.3 10.0 3.0 2.1 9.4 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Peptidase_M20 PF01546.28 CRG84021.1 - 5e-22 78.6 0.0 4.6e-21 75.5 0.0 2.4 3 0 0 3 3 3 1 Peptidase family M20/M25/M40 WD40 PF00400.32 CRG84021.1 - 1e-06 29.3 4.5 0.51 11.3 0.0 5.6 5 0 0 5 5 5 3 WD domain, G-beta repeat M20_dimer PF07687.14 CRG84021.1 - 1.6e-06 28.0 0.0 3.3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CRG84021.1 - 0.00085 19.1 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Endomucin PF07010.12 CRG84021.1 - 1.8 8.4 17.3 3.4 7.6 17.3 1.3 1 0 0 1 1 1 0 Endomucin TraQ PF09679.10 CRG84022.1 - 0.074 13.0 0.7 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin chaperone (TraQ) DAG_kinase_N PF14513.6 CRG84022.1 - 1.2 9.3 4.2 3 8.0 1.0 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus DUF349 PF03993.12 CRG84022.1 - 3.4 8.0 9.5 1.3 9.4 5.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) p450 PF00067.22 CRG84023.1 - 3.8e-68 230.3 0.0 5.3e-68 229.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 CRG84023.1 - 1.4e-13 50.8 0.0 3.1e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG84023.1 - 0.00022 20.6 0.1 0.11 11.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG84023.1 - 0.0047 17.1 0.2 0.013 15.7 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG84023.1 - 0.0057 15.7 0.0 0.011 14.8 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Amino_oxidase PF01593.24 CRG84023.1 - 0.033 13.5 1.2 1.7 7.8 0.2 2.4 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CRG84023.1 - 0.052 12.9 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Coiled-coil_56 PF09813.9 CRG84023.1 - 0.056 13.5 0.1 0.19 11.8 0.1 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 DAO PF01266.24 CRG84023.1 - 0.15 11.6 4.1 3 7.3 1.7 2.4 1 1 1 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG84023.1 - 0.2 10.7 1.3 2.1 7.3 0.7 2.2 1 1 1 2 2 2 0 FAD binding domain Oxidored_FMN PF00724.20 CRG84025.1 - 1.9e-63 214.8 0.0 2.3e-63 214.5 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CRG84025.1 - 2.1e-05 23.8 0.2 0.0011 18.2 0.0 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) p450 PF00067.22 CRG84026.1 - 7.5e-72 242.5 0.0 9.1e-72 242.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 zf-CHY PF05495.12 CRG84027.1 - 9.8e-11 42.0 10.6 9.8e-11 42.0 10.6 3.6 3 1 0 3 3 3 1 CHY zinc finger zf_CCCH_4 PF18345.1 CRG84027.1 - 0.0013 18.7 2.9 0.0013 18.7 2.9 2.1 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH PF00642.24 CRG84027.1 - 0.0015 18.4 0.7 0.0015 18.4 0.7 2.0 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CRG84027.1 - 0.0045 16.8 1.4 0.014 15.2 1.4 1.9 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CRG84027.1 - 0.0055 17.1 2.2 0.014 15.9 2.2 1.7 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger CENP-B_dimeris PF09026.10 CRG84027.1 - 9.8 6.6 14.1 12 6.4 7.2 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3295 PF11702.8 CRG84029.1 - 3.5e-177 590.7 24.1 4.3e-177 590.4 24.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 CRG84029.1 - 1.7e-11 43.7 2.1 3.2e-11 42.8 2.1 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Cpn60_TCP1 PF00118.24 CRG84030.1 - 8.7e-149 496.3 1.5 1.2e-148 495.8 1.5 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family 3Beta_HSD PF01073.19 CRG84030.1 - 1.8e-08 33.8 0.0 3.6e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG84030.1 - 0.00027 20.2 0.0 0.00054 19.2 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CRG84030.1 - 0.00067 19.6 0.0 0.0027 17.6 0.0 2.1 1 0 0 1 1 1 1 NAD(P)H-binding Chromo_shadow PF01393.19 CRG84031.1 - 4.2e-16 58.8 1.7 9e-12 44.9 0.5 2.2 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 CRG84031.1 - 1.2e-08 34.7 0.0 2.9e-08 33.5 0.0 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TT_ORF2 PF02957.15 CRG84031.1 - 2.8 8.9 6.9 0.42 11.5 1.8 1.9 2 0 0 2 2 2 0 TT viral ORF2 Myb_DNA-bind_2 PF08914.11 CRG84032.1 - 1.7e-21 76.1 1.0 5.7e-21 74.5 0.5 2.2 2 0 0 2 2 2 1 Rap1 Myb domain Rap1_C PF11626.8 CRG84032.1 - 6e-19 67.9 0.1 2.6e-17 62.7 0.0 2.4 2 0 0 2 2 2 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain BRCT_2 PF16589.5 CRG84032.1 - 5.2e-09 36.4 0.0 1.9e-08 34.6 0.0 1.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain Rap1-DNA-bind PF09197.10 CRG84032.1 - 0.00089 19.8 0.1 0.0025 18.4 0.1 1.8 1 0 0 1 1 1 1 Rap1, DNA-binding Myb_DNA-bind_6 PF13921.6 CRG84032.1 - 0.039 14.2 0.3 18 5.7 0.0 2.9 2 1 0 2 2 2 0 Myb-like DNA-binding domain TFIIA PF03153.13 CRG84032.1 - 0.11 12.4 10.4 0.15 12.0 10.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NIBRIN_BRCT_II PF16508.5 CRG84032.1 - 0.16 12.3 0.0 0.85 10.0 0.0 2.1 2 0 0 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein Totivirus_coat PF05518.11 CRG84032.1 - 4.9 5.1 9.1 6.6 4.7 9.1 1.1 1 0 0 1 1 1 0 Totivirus coat protein Ndc1_Nup PF09531.10 CRG84032.1 - 8.3 5.0 5.1 12 4.4 5.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DHHC PF01529.20 CRG84033.1 - 0.013 15.6 0.3 0.016 15.3 0.3 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase Gln-synt_N PF03951.19 CRG84033.1 - 0.14 11.9 0.0 3.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain Atx10homo_assoc PF09759.9 CRG84034.1 - 1.3e-31 108.5 1.8 1.3e-31 108.5 0.2 1.9 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain zf-RING_2 PF13639.6 CRG84035.1 - 1.4e-08 34.9 2.2 2.2e-08 34.3 2.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CRG84035.1 - 5.2e-06 26.6 2.5 7.9e-05 22.9 2.7 2.2 1 1 1 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CRG84035.1 - 0.00037 20.4 5.7 0.00063 19.7 5.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CRG84035.1 - 0.002 18.2 0.5 0.0029 17.6 0.5 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 CRG84035.1 - 0.006 16.4 3.9 0.054 13.3 4.1 2.1 1 1 1 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CRG84035.1 - 0.036 13.8 1.1 0.065 13.0 1.1 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_3 PF13920.6 CRG84035.1 - 0.084 12.7 1.4 0.87 9.5 1.4 2.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG84035.1 - 0.24 11.3 1.8 6 6.8 0.2 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Fungal_lectin_2 PF18647.1 CRG84036.1 - 6.6e-06 26.5 1.2 1.2e-05 25.6 0.5 1.7 2 0 0 2 2 2 1 Alpha-galactosyl-binding fungal lectin Ank_2 PF12796.7 CRG84038.1 - 1.6e-13 51.0 2.7 0.043 14.4 0.0 9.3 4 2 7 12 12 11 3 Ankyrin repeats (3 copies) NACHT PF05729.12 CRG84038.1 - 6e-09 36.0 0.2 3.5e-08 33.5 0.0 2.3 2 0 0 2 2 2 1 NACHT domain PNP_UDP_1 PF01048.20 CRG84038.1 - 6e-08 32.2 0.1 2.5e-07 30.2 0.1 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG84038.1 - 1.5e-06 28.7 0.0 6.6e-06 26.6 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CRG84038.1 - 0.00063 20.0 0.0 0.0029 17.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 CRG84038.1 - 0.006 17.0 0.0 0.018 15.4 0.0 1.8 1 0 0 1 1 1 1 RNA helicase AAA PF00004.29 CRG84038.1 - 0.026 15.0 0.0 0.026 15.0 0.0 4.6 6 0 0 6 6 5 0 ATPase family associated with various cellular activities (AAA) Ank_3 PF13606.6 CRG84038.1 - 0.034 14.7 0.0 37 5.3 0.0 5.3 3 0 0 3 3 3 0 Ankyrin repeat TFIIA_gamma_N PF02268.16 CRG84038.1 - 0.039 14.0 8.1 9 6.4 0.0 4.8 4 0 0 4 4 4 0 Transcription initiation factor IIA, gamma subunit, helical domain AAA_24 PF13479.6 CRG84038.1 - 0.052 13.3 0.5 0.21 11.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 CRG84038.1 - 0.054 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 CRG84038.1 - 0.084 12.4 0.1 1 8.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CRG84038.1 - 0.12 12.4 0.0 0.65 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) YflT PF11181.8 CRG84038.1 - 0.23 12.0 11.2 8.3 7.0 0.1 5.4 4 2 1 5 5 5 0 Heat induced stress protein YflT Hypoth_Ymh PF09509.10 CRG84038.1 - 0.8 9.6 2.5 19 5.2 0.1 4.2 5 0 0 5 5 5 0 Protein of unknown function (Hypoth_ymh) MARVEL PF01284.23 CRG84039.1 - 0.0059 16.6 17.9 0.011 15.7 17.7 1.5 1 1 0 1 1 1 1 Membrane-associating domain NTP_transferase PF00483.23 CRG84040.1 - 1.3e-31 110.0 0.0 1.9e-31 109.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 CRG84040.1 - 2.8e-08 33.2 7.7 4.9e-05 22.9 0.1 3.8 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CRG84040.1 - 3.9e-07 30.5 0.0 5.9e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 CRG84040.1 - 0.019 14.7 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Fucokinase PF07959.12 CRG84040.1 - 0.027 13.4 0.1 5.4 5.8 0.0 2.2 2 0 0 2 2 2 0 L-fucokinase Dynamin_N PF00350.23 CRG84041.1 - 1.5e-23 83.7 0.2 3.3e-22 79.3 0.0 2.9 2 1 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 CRG84041.1 - 9.8e-19 67.6 3.1 4.2e-16 59.0 0.0 2.7 3 0 0 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.23 CRG84041.1 - 0.0023 18.0 0.0 0.02 15.0 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CRG84041.1 - 0.025 14.8 0.0 0.27 11.5 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GED PF02212.18 CRG84041.1 - 0.073 13.2 1.5 0.24 11.6 0.2 2.6 2 0 0 2 2 2 0 Dynamin GTPase effector domain CM_1 PF07736.11 CRG84041.1 - 0.08 13.3 0.1 1.5 9.2 0.1 2.6 2 0 0 2 2 2 0 Chorismate mutase type I Trimer_CC PF08954.11 CRG84041.1 - 0.3 10.7 2.2 0.64 9.6 0.3 2.6 2 0 0 2 2 2 0 Trimerisation motif HTH_40 PF14493.6 CRG84041.1 - 0.3 11.6 1.6 2 8.9 0.4 3.0 3 0 0 3 3 3 0 Helix-turn-helix domain tRNA-synt_2 PF00152.20 CRG84043.1 - 8.3e-78 261.6 0.1 1.1e-77 261.2 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CRG84043.1 - 2.6e-13 49.8 0.2 6.7e-13 48.4 0.1 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CRG84043.1 - 2.1e-05 24.1 0.3 0.04 13.4 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti-like PF12869.7 CRG84043.1 - 0.011 15.3 0.5 0.011 15.3 0.5 2.3 1 1 1 2 2 2 0 tRNA_anti-like DUF2956 PF11169.8 CRG84043.1 - 2.2 8.5 8.7 5.1 7.3 8.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) COX15-CtaA PF02628.15 CRG84044.1 - 1.4e-116 389.1 2.0 1.7e-116 388.8 2.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein PQ-loop PF04193.14 CRG84044.1 - 7.8 6.4 6.8 12 5.7 0.2 3.0 3 0 0 3 3 3 0 PQ loop repeat zf-C3HC PF07967.13 CRG84045.1 - 3.6e-41 140.3 0.2 2.3e-36 124.7 0.1 2.3 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 CRG84045.1 - 2.7e-31 107.6 0.2 4e-28 97.4 0.0 2.5 2 0 0 2 2 2 2 Rsm1-like DM PF00751.18 CRG84045.1 - 0.026 14.4 0.9 0.35 10.8 0.2 2.4 2 0 0 2 2 2 0 DM DNA binding domain Peptidase_M29 PF02073.15 CRG84045.1 - 0.14 10.9 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) Pox_MCEL PF03291.16 CRG84046.1 - 6.5e-68 229.3 0.0 1.8e-65 221.3 0.0 3.1 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_12 PF08242.12 CRG84046.1 - 4.7e-09 36.9 0.0 2e-08 34.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84046.1 - 8.1e-09 36.1 0.0 0.00029 21.5 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CRG84046.1 - 3.5e-05 24.4 0.0 0.44 11.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 CRG84046.1 - 0.00024 20.9 0.0 0.019 14.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CRG84046.1 - 0.0032 16.7 0.0 0.0055 15.9 0.0 1.3 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 CRG84046.1 - 0.0034 17.2 0.0 0.0075 16.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CRG84047.1 - 1e-24 87.1 0.0 5.6e-18 65.1 0.1 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG84047.1 - 3.2e-13 49.8 0.0 1.2e-06 28.2 0.0 2.1 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG84047.1 - 7.8e-06 25.9 0.1 1.2e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG84047.1 - 0.088 11.9 0.1 0.21 10.7 0.0 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Lactamase_B PF00753.27 CRG84048.1 - 8.7e-06 25.9 0.0 1.6e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Glyco_hydro_106 PF17132.4 CRG84050.1 - 1.7e-24 86.1 0.0 2.3e-21 75.8 0.4 2.1 2 0 0 2 2 2 2 alpha-L-rhamnosidase FAD_binding_4 PF01565.23 CRG84052.1 - 1e-21 77.1 1.2 2.4e-21 75.9 1.2 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG84052.1 - 0.00032 20.7 0.0 0.0007 19.6 0.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like DUF3124 PF11322.8 CRG84052.1 - 0.026 14.7 0.3 1.8 8.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3124) p450 PF00067.22 CRG84054.1 - 2.4e-35 122.2 0.0 3e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CRG84055.1 - 7.7e-19 67.9 0.0 4.9e-14 52.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CRG84055.1 - 2.8e-06 27.4 0.0 4.6e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG84055.1 - 0.00096 18.7 0.1 0.0054 16.2 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG84055.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG84055.1 - 0.072 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family p450 PF00067.22 CRG84056.1 - 5e-34 117.8 0.1 1.1e-33 116.7 0.0 1.6 2 0 0 2 2 2 1 Cytochrome P450 p450 PF00067.22 CRG84057.1 - 3.9e-49 167.6 0.0 5.6e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 CRG84058.1 - 9e-48 161.5 7.6 1e-23 83.6 0.2 2.5 2 0 0 2 2 2 2 FAD binding domain BBE PF08031.12 CRG84058.1 - 0.00012 22.0 0.0 0.0085 16.2 0.0 2.6 2 0 0 2 2 2 1 Berberine and berberine like zf-Nse PF11789.8 CRG84059.1 - 1.8e-21 75.7 0.1 3.5e-21 74.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 CRG84059.1 - 0.00013 21.9 0.0 0.00085 19.3 0.0 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-MIZ PF02891.20 CRG84059.1 - 0.00013 21.6 0.9 0.0017 18.1 0.1 2.2 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger ApoC-I PF04691.12 CRG84059.1 - 0.00094 19.1 1.1 0.079 12.9 0.1 2.9 3 0 0 3 3 3 1 Apolipoprotein C-I (ApoC-1) NOA36 PF06524.12 CRG84059.1 - 0.0018 17.6 1.7 0.0018 17.6 1.7 3.4 4 0 0 4 4 4 2 NOA36 protein DUF2457 PF10446.9 CRG84059.1 - 0.0055 15.9 4.0 0.0055 15.9 4.0 3.8 2 1 2 4 4 4 1 Protein of unknown function (DUF2457) zf-C3HC4_2 PF13923.6 CRG84059.1 - 0.0064 16.3 0.3 0.057 13.3 0.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG84059.1 - 0.23 11.4 0.1 1 9.3 0.1 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) COG2 PF06148.11 CRG84059.1 - 6.6 6.8 9.8 2 8.5 2.1 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 YtxH PF12732.7 CRG84059.1 - 7.9 7.1 8.8 7.4 7.2 1.3 2.6 2 0 0 2 2 2 0 YtxH-like protein Mito_carr PF00153.27 CRG84060.1 - 4.2e-54 180.5 3.3 8.3e-18 64.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Aldo_ket_red PF00248.21 CRG84061.1 - 3.2e-39 134.9 0.0 2.6e-37 128.6 0.0 2.5 1 1 1 2 2 2 1 Aldo/keto reductase family HTH_Tnp_1 PF01527.20 CRG84061.1 - 0.019 15.3 0.0 3.5 8.0 0.0 3.2 3 0 0 3 3 3 0 Transposase APH PF01636.23 CRG84062.1 - 6e-15 55.8 0.2 3.3e-14 53.4 0.2 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family HNH_2 PF13391.6 CRG84062.1 - 0.018 15.1 1.3 0.11 12.6 0.0 2.4 2 0 0 2 2 2 0 HNH endonuclease Choline_kinase PF01633.20 CRG84062.1 - 0.095 12.3 0.1 0.2 11.2 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Tri3 PF07428.11 CRG84063.1 - 2.4e-08 33.3 0.1 9.1e-07 28.1 0.0 2.3 1 1 2 3 3 3 2 15-O-acetyltransferase Tri3 Fungal_trans PF04082.18 CRG84064.1 - 2.8e-11 43.0 2.5 4.2e-11 42.4 2.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG84065.1 - 1.1e-27 96.9 77.6 2.3e-22 79.4 49.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG84065.1 - 0.84 7.8 15.2 0.011 14.1 2.4 2.8 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Na_H_Exchanger PF00999.21 CRG84067.1 - 1.3e-46 159.2 7.6 1.8e-46 158.7 7.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family HupE_UreJ PF04955.12 CRG84067.1 - 0.11 11.9 0.1 0.11 11.9 0.1 2.5 3 0 0 3 3 3 0 HupE / UreJ protein Virul_fac_BrkB PF03631.15 CRG84067.1 - 0.19 11.3 8.8 0.39 10.3 1.8 3.1 1 1 1 2 2 2 0 Virulence factor BrkB PEX11 PF05648.14 CRG84068.1 - 9.7e-74 247.6 0.1 1.1e-73 247.4 0.1 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Sugar_tr PF00083.24 CRG84070.1 - 2.5e-32 112.3 25.6 1.5e-20 73.5 7.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG84070.1 - 2.4e-15 56.3 35.7 2.4e-15 56.3 35.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily RPN7 PF10602.9 CRG84071.1 - 1.6e-54 184.3 1.1 2.8e-54 183.5 1.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 Aminotran_1_2 PF00155.21 CRG84071.1 - 2.9e-41 141.9 0.0 6.6e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II PCI PF01399.27 CRG84071.1 - 3.3e-13 50.1 0.0 9.5e-13 48.6 0.0 1.9 1 0 0 1 1 1 1 PCI domain TPR_7 PF13176.6 CRG84071.1 - 0.064 13.3 0.0 0.23 11.6 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat LigB PF02900.18 CRG84071.1 - 0.17 10.9 0.0 0.42 9.6 0.0 1.6 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Copper-fist PF00649.18 CRG84072.1 - 1.9e-21 75.2 2.6 5.4e-21 73.8 2.6 1.8 1 0 0 1 1 1 1 Copper fist DNA binding domain Zn_clus PF00172.18 CRG84074.1 - 1.8e-10 40.8 8.9 3e-10 40.0 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex14_N PF04695.13 CRG84074.1 - 0.2 12.3 2.4 0.78 10.4 2.4 2.0 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SSP160 PF06933.11 CRG84074.1 - 2.4 6.3 8.9 4.6 5.3 8.9 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Meiotic_rec114 PF03525.14 CRG84075.1 - 0.0033 16.4 11.6 0.11 11.5 0.3 2.6 2 1 0 2 2 2 2 Meiotic recombination protein rec114 Pre-PUA PF17832.1 CRG84075.1 - 0.4 11.4 3.0 4.6 8.0 0.3 3.1 3 1 1 4 4 4 0 Pre-PUA-like domain ARID PF01388.21 CRG84076.1 - 1.1e-06 29.3 0.0 2.6e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain zf_ZIC PF18366.1 CRG84076.1 - 0.024 14.7 0.2 0.085 13.0 0.1 2.0 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2 PF00096.26 CRG84076.1 - 0.062 13.8 0.3 0.19 12.3 0.3 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type RFX_DNA_binding PF02257.15 CRG84076.1 - 0.13 12.9 0.0 0.31 11.7 0.0 1.5 1 0 0 1 1 1 0 RFX DNA-binding domain DUF2967 PF11179.8 CRG84077.1 - 0.64 8.0 33.1 0.76 7.8 33.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Apt1 PF10351.9 CRG84077.1 - 0.83 8.4 17.9 1 8.2 17.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 CRG84077.1 - 1.1 7.7 19.0 1.3 7.5 19.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF4614 PF15391.6 CRG84077.1 - 3.2 7.7 21.4 3.6 7.5 18.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) DUF572 PF04502.13 CRG84077.1 - 3.3 7.2 6.6 3.6 7.1 6.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2057 PF09829.9 CRG84077.1 - 5 7.2 12.9 5.1 7.2 11.9 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) SPX PF03105.19 CRG84077.1 - 6.5 6.6 16.0 7.3 6.4 16.0 1.1 1 0 0 1 1 1 0 SPX domain HSD3 PF15244.6 CRG84077.1 - 9.2 5.7 15.2 12 5.2 15.2 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 DUF1771 PF08590.10 CRG84078.1 - 2e-11 44.1 4.5 4.1e-11 43.1 4.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.16 CRG84078.1 - 4.3e-06 26.3 0.0 9e-06 25.3 0.0 1.6 1 0 0 1 1 1 1 CUE domain Smr PF01713.21 CRG84078.1 - 0.00034 20.9 0.4 0.001 19.4 0.4 1.9 1 0 0 1 1 1 1 Smr domain HalX PF08663.10 CRG84078.1 - 0.11 12.8 0.2 0.3 11.4 0.2 1.6 1 0 0 1 1 1 0 HalX domain SelR PF01641.18 CRG84079.1 - 6.3e-51 171.5 0.1 1.3e-50 170.5 0.1 1.5 2 0 0 2 2 2 1 SelR domain DZR PF12773.7 CRG84079.1 - 0.033 14.2 0.3 8.8 6.4 0.1 2.4 2 0 0 2 2 2 0 Double zinc ribbon GFA PF04828.14 CRG84079.1 - 0.04 14.2 0.2 1.9 8.9 0.0 2.3 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_10 PF10058.9 CRG84079.1 - 0.048 13.4 0.2 0.6 9.9 0.0 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Tnp_zf-ribbon_2 PF13842.6 CRG84079.1 - 0.11 13.3 0.2 15 6.5 0.0 2.6 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DUF2076 PF09849.9 CRG84079.1 - 0.12 12.4 0.1 0.17 11.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-ribbon_3 PF13248.6 CRG84079.1 - 0.49 9.9 2.6 19 4.8 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain ArfGap PF01412.18 CRG84080.1 - 2.4e-40 137.2 0.4 3.6e-40 136.7 0.4 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf FSA_C PF10479.9 CRG84080.1 - 2.2 6.3 12.3 4.1 5.4 12.3 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ANAPC4_WD40 PF12894.7 CRG84081.1 - 2.3e-10 40.6 0.2 0.017 15.4 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG84081.1 - 1.7e-06 28.6 14.1 0.00027 21.7 0.1 5.5 5 1 0 5 5 5 1 WD domain, G-beta repeat IKI3 PF04762.12 CRG84081.1 - 0.00051 18.2 0.0 0.01 13.9 0.0 2.0 1 1 1 2 2 2 2 IKI3 family Nup160 PF11715.8 CRG84081.1 - 0.0085 14.8 0.0 0.015 13.9 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CRG84081.1 - 0.011 14.3 0.0 0.024 13.2 0.0 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain eIF2A PF08662.11 CRG84081.1 - 0.025 14.5 0.0 0.33 10.8 0.0 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A EF_assoc_2 PF08356.12 CRG84085.1 - 1.7e-35 120.8 0.0 3.4e-35 119.9 0.0 1.5 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 CRG84085.1 - 1.5e-30 104.6 0.6 3e-30 103.6 0.2 1.7 2 0 0 2 2 1 1 EF hand associated Ras PF00071.22 CRG84085.1 - 4.1e-24 85.0 0.0 2.4e-13 50.0 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CRG84085.1 - 3e-13 50.0 0.0 4.1e-08 33.5 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CRG84085.1 - 5e-09 36.2 0.0 0.00023 21.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG84085.1 - 1.9e-05 25.1 0.3 0.076 13.4 0.0 2.6 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CRG84085.1 - 3e-05 23.7 0.2 0.026 14.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CRG84085.1 - 0.00017 21.9 0.3 1.5 9.1 0.0 3.0 2 1 1 3 3 3 2 AAA domain EF-hand_1 PF00036.32 CRG84085.1 - 0.00026 20.3 1.0 0.22 11.2 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CRG84085.1 - 0.00043 20.7 0.1 0.094 13.2 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair AAA_28 PF13521.6 CRG84085.1 - 0.0014 18.9 0.1 0.77 10.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain EF-hand_6 PF13405.6 CRG84085.1 - 0.002 17.9 0.9 2.5 8.3 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain Viral_helicase1 PF01443.18 CRG84085.1 - 0.002 17.9 0.3 0.056 13.2 0.0 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Dynamin_N PF00350.23 CRG84085.1 - 0.0027 17.8 0.1 0.56 10.2 0.0 2.6 2 0 0 2 2 2 1 Dynamin family AAA_18 PF13238.6 CRG84085.1 - 0.0048 17.4 0.1 2 9.0 0.1 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CRG84085.1 - 0.0066 16.4 0.8 4.9 7.1 0.0 3.2 3 1 0 3 3 3 1 NACHT domain RsgA_GTPase PF03193.16 CRG84085.1 - 0.0076 16.2 0.1 2 8.3 0.0 3.2 3 0 0 3 3 3 1 RsgA GTPase RNA_helicase PF00910.22 CRG84085.1 - 0.0091 16.4 0.0 1.1 9.6 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 CRG84085.1 - 0.01 15.5 0.1 3.3 7.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain Ploopntkinase3 PF18751.1 CRG84085.1 - 0.014 15.4 0.0 1.4 8.8 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 ABC_tran PF00005.27 CRG84085.1 - 0.014 15.9 0.0 10 6.6 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 CRG84085.1 - 0.034 13.9 0.1 0.43 10.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CRG84085.1 - 0.034 13.6 0.1 1.7 8.1 0.0 2.5 2 1 0 2 2 2 0 P-loop containing dynein motor region EF-hand_10 PF14788.6 CRG84085.1 - 0.041 13.7 1.0 0.38 10.6 0.2 2.3 2 0 0 2 2 2 0 EF hand FtsK_SpoIIIE PF01580.18 CRG84085.1 - 0.042 13.2 0.1 4 6.7 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.14 CRG84085.1 - 0.048 13.7 0.2 24 4.9 0.0 3.2 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF815 PF05673.13 CRG84085.1 - 0.073 12.2 0.1 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Septin PF00735.18 CRG84085.1 - 0.091 12.0 0.0 0.81 8.9 0.1 2.1 2 0 0 2 2 2 0 Septin AAA_33 PF13671.6 CRG84085.1 - 0.096 12.8 0.3 22 5.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 CRG84085.1 - 0.11 12.1 0.0 28 4.2 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain SMC_N PF02463.19 CRG84085.1 - 0.25 10.7 0.5 6.5 6.1 0.1 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Ysc84 PF04366.12 CRG84086.1 - 4.1e-43 146.2 0.3 7.2e-43 145.4 0.3 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 CRG84086.1 - 9.5e-14 50.7 0.2 3.4e-13 49.0 0.1 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 CRG84086.1 - 6.6e-11 41.7 0.0 1.4e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 CRG84086.1 - 8.7e-11 41.5 0.0 1.9e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Arrestin_C PF02752.22 CRG84087.1 - 2.2e-18 67.0 0.1 3.9e-18 66.2 0.1 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 CRG84087.1 - 1.2e-08 35.1 0.0 2.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain HIT PF01230.23 CRG84088.1 - 0.00014 22.5 0.0 0.87 10.4 0.0 2.4 2 0 0 2 2 2 2 HIT domain GAF_3 PF13492.6 CRG84088.1 - 0.091 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 GAF domain HCBP_related PF06594.11 CRG84089.1 - 0.076 13.0 0.6 0.22 11.5 0.6 1.8 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain PH PF00169.29 CRG84089.1 - 0.13 12.8 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 PH domain Acetyltransf_3 PF13302.7 CRG84090.1 - 5.8e-10 40.0 0.2 1.3e-09 38.8 0.2 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG84090.1 - 0.00012 22.3 0.0 0.00024 21.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CRG84090.1 - 0.0071 16.5 0.0 0.018 15.1 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Glyoxalase PF00903.25 CRG84092.1 - 1.6e-33 115.6 0.0 2.6e-18 66.4 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CRG84092.1 - 1.9e-17 63.5 0.0 2.9e-08 34.0 0.0 3.7 2 2 1 3 3 3 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 CRG84092.1 - 7.2e-07 30.0 0.0 0.008 17.0 0.0 2.6 2 1 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CRG84092.1 - 1.1e-06 28.9 0.0 0.014 15.5 0.0 2.5 1 1 1 2 2 2 2 Glyoxalase-like domain Glyoxalase_2 PF12681.7 CRG84092.1 - 0.015 15.2 0.4 15 5.6 0.0 3.4 4 0 0 4 4 4 0 Glyoxalase-like domain MoaF PF10703.9 CRG84092.1 - 0.08 12.9 0.0 4.2 7.4 0.0 2.5 2 0 0 2 2 2 0 MoaF N-terminal domain Fungal_trans PF04082.18 CRG84093.1 - 1.9e-16 59.9 0.0 5.4e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_23 PF13489.6 CRG84093.1 - 5.4e-14 52.4 0.0 2.3e-13 50.3 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84093.1 - 3.8e-11 43.5 0.0 1.4e-10 41.8 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG84093.1 - 5.2e-11 43.1 0.1 2.6e-10 40.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG84093.1 - 2.1e-10 40.6 0.0 6.2e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG84093.1 - 2.8e-10 40.8 0.3 5e-09 36.8 0.0 3.0 3 0 0 3 3 3 1 Methyltransferase domain Zn_clus PF00172.18 CRG84093.1 - 5.5e-10 39.2 22.9 5.6e-08 32.8 13.3 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Ubie_methyltran PF01209.18 CRG84093.1 - 0.0042 16.5 0.0 0.0087 15.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DREV PF05219.12 CRG84093.1 - 0.017 14.2 0.0 0.041 13.0 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase COesterase PF00135.28 CRG84094.1 - 4.8e-93 312.8 0.0 5.9e-93 312.5 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG84094.1 - 3.7e-07 30.2 0.0 1.2e-06 28.6 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG84094.1 - 0.025 14.1 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Fungal_trans_2 PF11951.8 CRG84096.1 - 1.9e-09 36.8 0.3 3.6e-09 35.9 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84096.1 - 3.5e-07 30.2 12.8 7e-07 29.3 12.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fe-ADH PF00465.19 CRG84097.1 - 6.3e-102 341.1 0.0 8.2e-102 340.7 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CRG84097.1 - 3.2e-15 56.5 0.1 1.4e-11 44.6 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 CRG84097.1 - 0.0015 18.3 0.1 0.0026 17.5 0.1 1.4 1 0 0 1 1 1 1 Periplasmic binding protein Ion_trans PF00520.31 CRG84098.1 - 1.5e-07 30.9 2.0 2e-07 30.5 2.0 1.1 1 0 0 1 1 1 1 Ion transport protein Vac_Fusion PF02346.16 CRG84098.1 - 0.14 11.8 2.3 0.39 10.4 0.9 2.1 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Bys1 PF04681.12 CRG84100.1 - 1.2e-14 54.6 0.9 1.4e-14 54.3 0.9 1.0 1 0 0 1 1 1 1 Blastomyces yeast-phase-specific protein Sugar_tr PF00083.24 CRG84102.1 - 6e-108 361.6 28.7 6.9e-108 361.4 28.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84102.1 - 2.7e-15 56.2 34.7 2.7e-15 56.2 34.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily HPP PF04982.13 CRG84102.1 - 3.3 7.9 14.0 0.096 12.9 2.8 3.6 2 2 2 4 4 4 0 HPP family ATP1G1_PLM_MAT8 PF02038.16 CRG84102.1 - 3.6 7.1 4.7 0.92 9.0 0.6 2.2 2 0 0 2 2 2 0 ATP1G1/PLM/MAT8 family Zn_clus PF00172.18 CRG84103.1 - 1e-06 28.7 8.1 1e-06 28.7 8.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ldl_recept_a PF00057.18 CRG84103.1 - 2.3 8.5 8.0 10 6.4 3.3 2.5 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A ADH_zinc_N PF00107.26 CRG84104.1 - 2.2e-25 89.1 0.1 3.8e-25 88.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG84104.1 - 6e-21 74.4 1.9 6e-21 74.4 1.9 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CRG84104.1 - 3e-05 25.1 0.0 6.9e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG84104.1 - 0.0085 15.6 0.5 0.016 14.7 0.5 1.5 1 0 0 1 1 1 1 short chain dehydrogenase AlaDh_PNT_C PF01262.21 CRG84104.1 - 0.023 14.0 1.6 0.038 13.3 1.6 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Haem_degrading PF03928.14 CRG84105.1 - 1.7e-36 124.9 0.1 2.1e-36 124.5 0.1 1.1 1 0 0 1 1 1 1 Haem-degrading FUSC PF04632.12 CRG84105.1 - 0.031 12.8 0.1 0.039 12.5 0.1 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family HSP70 PF00012.20 CRG84107.1 - 6.8e-261 866.7 11.4 7.8e-261 866.5 11.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CRG84107.1 - 1.9e-17 63.1 1.1 2.8e-16 59.2 0.3 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 CRG84107.1 - 0.0043 16.1 0.7 0.021 13.8 0.2 2.0 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain DUF1464 PF07318.12 CRG84107.1 - 0.029 13.5 0.2 1.2 8.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1464) FtsA PF14450.6 CRG84107.1 - 0.14 12.6 6.8 17 5.9 0.2 3.8 3 2 0 3 3 3 0 Cell division protein FtsA HEPPP_synt_1 PF07307.11 CRG84107.1 - 0.17 11.5 0.7 0.3 10.7 0.7 1.4 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Hydantoinase_A PF01968.18 CRG84107.1 - 0.28 10.4 3.4 0.64 9.2 0.1 2.8 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase FIVAR PF07554.13 CRG84107.1 - 0.93 10.3 3.1 87 4.0 0.0 3.8 3 1 0 3 3 3 0 FIVAR domain AXE1 PF05448.12 CRG84108.1 - 4.6e-09 35.4 0.0 2.7e-05 23.0 0.0 3.0 2 1 0 2 2 2 2 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 CRG84108.1 - 8.8e-09 35.3 0.0 1.3e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 CRG84108.1 - 1e-07 31.6 0.1 2.7e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CRG84108.1 - 2.1e-07 30.9 0.1 4.8e-07 29.7 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG84108.1 - 2.9e-07 31.3 0.1 4.1e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 CRG84108.1 - 1.5e-05 25.1 0.0 0.00013 22.0 0.0 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 CRG84108.1 - 2.7e-05 23.6 0.0 0.064 12.5 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 CRG84108.1 - 0.025 14.1 0.0 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family PS_Dcarbxylase PF02666.15 CRG84109.1 - 5.2e-60 202.4 0.1 8.7e-60 201.7 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase GTP_EFTU PF00009.27 CRG84110.1 - 1.4e-50 171.6 0.0 2.5e-50 170.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 CRG84110.1 - 1.3e-17 63.9 3.9 2.7e-17 62.8 3.9 1.5 1 0 0 1 1 1 1 HBS1 N-terminus MMR_HSR1 PF01926.23 CRG84110.1 - 1.8e-08 34.4 0.1 4.7e-07 29.9 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D3 PF03143.17 CRG84110.1 - 3.3e-08 33.8 0.0 1.2e-07 32.0 0.0 2.1 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CRG84110.1 - 4.7e-06 26.9 0.0 1.4e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Gtr1_RagA PF04670.12 CRG84110.1 - 0.00014 21.3 0.1 0.00029 20.3 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 CRG84110.1 - 0.0032 17.0 0.5 0.087 12.4 0.1 2.9 2 1 0 2 2 2 1 Ferrous iron transport protein B SRPRB PF09439.10 CRG84110.1 - 0.0033 16.9 0.0 0.35 10.3 0.0 2.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CRG84110.1 - 0.0076 16.5 0.0 1.9 8.7 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG84110.1 - 0.0084 15.6 0.0 2.5 7.5 0.0 2.3 1 1 1 2 2 2 2 ADP-ribosylation factor family Septin PF00735.18 CRG84110.1 - 0.042 13.1 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Septin G-alpha PF00503.20 CRG84110.1 - 0.1 11.7 0.0 6.4 5.8 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit Dynamin_N PF00350.23 CRG84110.1 - 0.12 12.4 0.3 9.6 6.2 0.0 2.9 2 1 1 3 3 3 0 Dynamin family MSA-2c PF12238.8 CRG84110.1 - 0.87 9.6 5.3 2.1 8.3 5.3 1.7 1 0 0 1 1 1 0 Merozoite surface antigen 2c Nefa_Nip30_N PF10187.9 CRG84110.1 - 2.1 8.7 12.6 1.3 9.4 2.4 2.5 2 0 0 2 2 2 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 PBP1_TM PF14812.6 CRG84110.1 - 3.4 8.1 4.9 11 6.5 4.9 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pro-kuma_activ PF09286.11 CRG84112.1 - 9e-39 133.0 0.1 1.4e-38 132.4 0.1 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG84112.1 - 2.9e-05 23.5 0.0 6.2e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Subtilase family UCH_1 PF13423.6 CRG84113.1 - 1.2e-94 317.5 0.4 1.7e-94 317.0 0.4 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 CRG84113.1 - 5.8e-16 59.5 0.0 3e-15 57.2 0.0 2.1 2 0 0 2 2 2 1 Exonuclease UCH PF00443.29 CRG84113.1 - 0.0002 21.0 0.0 0.00077 19.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Lipase_3 PF01764.25 CRG84115.1 - 4.9e-36 123.7 0.0 8.5e-36 122.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 CRG84115.1 - 4.5e-10 39.4 1.1 8.1e-10 38.6 0.2 1.9 2 0 0 2 2 2 1 Lipase 3 N-terminal region Hydrolase_4 PF12146.8 CRG84115.1 - 0.00072 18.9 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CRG84115.1 - 0.012 15.7 0.1 0.02 15.0 0.1 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_6 PF12697.7 CRG84115.1 - 0.015 15.9 0.0 0.019 15.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 CRG84115.1 - 0.056 13.0 0.1 0.49 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Pkinase PF00069.25 CRG84116.1 - 4.1e-72 242.7 0.0 7.2e-72 241.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84116.1 - 5.5e-46 156.9 0.0 1.1e-45 156.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase VHS PF00790.19 CRG84116.1 - 4.3e-35 120.6 0.6 1.1e-34 119.4 0.6 1.6 1 0 0 1 1 1 1 VHS domain PBD PF00786.28 CRG84116.1 - 7.6e-21 74.2 0.1 3.2e-20 72.2 0.1 2.2 1 0 0 1 1 1 1 P21-Rho-binding domain SH3_1 PF00018.28 CRG84116.1 - 3.1e-16 58.7 0.1 1.2e-15 56.9 0.0 2.1 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 CRG84116.1 - 1.8e-14 53.3 0.1 3.8e-14 52.3 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CRG84116.1 - 6.3e-14 51.4 0.0 1.3e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 CRG84116.1 - 5e-10 39.6 1.5 1.5e-09 38.1 1.5 1.9 1 0 0 1 1 1 1 GAT domain Kinase-like PF14531.6 CRG84116.1 - 2.9e-07 30.1 0.0 5.8e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CRG84116.1 - 3.3e-07 29.4 1.0 2.2e-06 26.7 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase UIM PF02809.20 CRG84116.1 - 0.015 15.2 1.3 0.048 13.6 1.3 2.0 1 0 0 1 1 1 0 Ubiquitin interaction motif DSHCT PF08148.12 CRG84116.1 - 0.037 13.7 0.2 0.28 10.8 0.0 2.5 3 0 0 3 3 3 0 DSHCT (NUC185) domain Ilar_coat PF01787.16 CRG84116.1 - 0.05 13.4 3.1 0.18 11.6 3.1 2.0 1 0 0 1 1 1 0 Ilarvirus coat protein Kdo PF06293.14 CRG84116.1 - 0.077 12.3 0.0 0.077 12.3 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4598 PF15370.6 CRG84116.1 - 0.21 12.1 0.1 0.21 12.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4598) APH PF01636.23 CRG84116.1 - 1.1 9.1 4.3 0.76 9.6 0.0 2.6 2 1 1 3 3 2 0 Phosphotransferase enzyme family Trypan_PARP PF05887.11 CRG84117.1 - 0.0036 17.3 7.9 0.0054 16.7 7.9 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) KH_1 PF00013.29 CRG84118.1 - 1.1e-97 319.9 31.9 1.1e-12 47.5 0.2 14.1 13 2 0 13 13 13 9 KH domain SLS PF14611.6 CRG84118.1 - 8.2e-15 55.2 6.3 0.29 10.9 0.0 7.7 5 4 2 8 8 8 5 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 CRG84118.1 - 7.3e-13 48.2 21.3 0.0088 15.9 0.0 7.7 6 1 1 7 7 7 4 KH domain KH_4 PF13083.6 CRG84118.1 - 0.00051 19.9 1.3 39 4.2 0.1 5.0 4 0 0 4 4 4 0 KH domain LeuA_dimer PF08502.10 CRG84118.1 - 0.013 15.4 0.2 1.5 8.7 0.0 2.9 2 0 0 2 2 2 0 LeuA allosteric (dimerisation) domain RL10P_insert PF17777.1 CRG84118.1 - 0.07 13.1 0.1 0.23 11.5 0.1 1.9 1 0 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P KH_5 PF13184.6 CRG84118.1 - 1 9.5 10.0 58 3.9 0.2 5.8 6 0 0 6 6 6 0 NusA-like KH domain Glyoxalase_6 PF18029.1 CRG84120.1 - 0.002 18.9 0.0 0.0031 18.3 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain PalH PF08733.10 CRG84121.1 - 2.3e-113 378.6 0.0 2.7e-113 378.3 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 PLAC8 PF04749.17 CRG84122.1 - 6.5e-19 68.8 18.0 9.6e-19 68.2 18.0 1.3 1 0 0 1 1 1 1 PLAC8 family TIP120 PF08623.10 CRG84123.1 - 5.4e-64 215.0 0.4 2.6e-62 209.5 0.2 3.4 3 0 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 CRG84123.1 - 1.1e-11 43.9 16.0 0.05 13.9 0.0 11.8 13 0 0 13 13 10 2 HEAT repeat HEAT_2 PF13646.6 CRG84123.1 - 2e-11 44.1 17.6 0.055 13.9 0.0 8.8 9 1 1 10 10 9 3 HEAT repeats Adaptin_N PF01602.20 CRG84123.1 - 4.4e-10 38.7 3.6 0.0015 17.2 0.1 5.5 5 2 1 6 6 6 3 Adaptin N terminal region HEAT_EZ PF13513.6 CRG84123.1 - 1e-05 25.9 23.3 0.51 10.9 0.0 10.8 13 0 0 13 13 12 1 HEAT-like repeat ParcG PF10274.9 CRG84123.1 - 0.0097 16.0 1.4 30 4.7 0.0 4.2 3 1 1 4 4 4 0 Parkin co-regulated protein UME PF08064.13 CRG84123.1 - 0.011 15.6 3.0 4.2 7.3 0.0 5.6 6 1 0 7 7 7 0 UME (NUC010) domain RTP1_C1 PF10363.9 CRG84123.1 - 0.011 15.9 6.5 3.5 7.8 0.0 5.6 6 0 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 CRG84123.1 - 0.015 15.4 2.9 9.8 6.2 0.0 5.0 6 0 0 6 6 5 0 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 CRG84123.1 - 0.03 14.3 1.9 56 3.7 0.0 4.5 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central ERAP1_C PF11838.8 CRG84123.1 - 0.036 13.6 3.7 13 5.3 0.1 5.4 5 2 3 8 8 8 0 ERAP1-like C-terminal domain PWI PF01480.17 CRG84123.1 - 0.099 13.0 0.7 2 8.8 0.0 3.1 3 0 0 3 3 2 0 PWI domain BAG6 PF12057.8 CRG84123.1 - 0.1 12.2 0.1 30 4.3 0.0 3.2 2 0 0 2 2 2 0 BCL2-associated athanogene 6 TAF6_C PF07571.13 CRG84123.1 - 0.12 12.8 0.0 2.1 8.7 0.0 3.3 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain DUF3295 PF11702.8 CRG84123.1 - 0.18 11.1 1.8 0.36 10.1 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DUF3385 PF11865.8 CRG84123.1 - 0.48 10.3 3.9 20 5.0 0.0 4.4 5 1 0 6 6 6 0 Domain of unknown function (DUF3385) PATR PF12951.7 CRG84123.1 - 3.9 7.7 5.0 5.3 7.2 0.8 2.6 2 0 0 2 2 2 0 Passenger-associated-transport-repeat TRAM_LAG1_CLN8 PF03798.16 CRG84126.1 - 1.5e-39 135.8 23.0 1.5e-39 135.8 23.0 1.5 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 CRG84126.1 - 8.7e-23 79.8 0.0 8.7e-23 79.8 0.0 2.2 2 1 0 2 2 2 1 TRAM1-like protein Glyco_hydro_127 PF07944.12 CRG84128.1 - 1.1e-19 70.4 0.0 9.5e-17 60.7 0.0 2.1 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 DUF5011 PF16403.5 CRG84128.1 - 0.13 12.5 0.5 0.34 11.1 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5011) Transglut_core PF01841.19 CRG84130.1 - 1.1e-12 48.4 0.0 1.9e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF553 PF04473.12 CRG84130.1 - 0.0073 15.8 0.0 0.034 13.7 0.0 2.0 1 1 0 1 1 1 1 Transglutaminase-like domain Gln_amidase PF15644.6 CRG84130.1 - 0.071 14.1 0.0 0.21 12.6 0.0 1.9 1 0 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase Ras PF00071.22 CRG84131.1 - 1.5e-30 105.9 0.1 1.9e-30 105.6 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG84131.1 - 2.7e-23 82.4 0.1 4.6e-23 81.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG84131.1 - 1.7e-06 27.6 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CRG84131.1 - 0.00013 21.4 0.1 0.00017 21.0 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 CRG84131.1 - 0.016 14.0 0.1 2.6 6.8 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) G-alpha PF00503.20 CRG84131.1 - 0.044 12.9 0.7 0.19 10.9 0.7 2.1 1 1 0 1 1 1 0 G-protein alpha subunit CAF1C_H4-bd PF12265.8 CRG84132.1 - 5.9e-16 58.5 0.0 4.4e-15 55.7 0.0 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CRG84132.1 - 3.8e-11 43.4 11.8 4.8e-06 27.2 0.1 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG84132.1 - 1.7e-08 34.6 0.5 0.00042 20.6 0.1 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG84132.1 - 0.042 12.5 2.5 0.6 8.7 0.2 2.1 1 1 0 2 2 2 0 Nucleoporin Nup120/160 MFS_1 PF07690.16 CRG84133.1 - 1.7e-34 119.3 24.9 1.7e-34 119.3 24.9 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily NAD_binding_2 PF03446.15 CRG84134.1 - 5.9e-30 104.5 0.0 8.1e-30 104.1 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG84134.1 - 3.6e-13 49.8 0.0 5.3e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CRG84134.1 - 1e-07 32.4 0.0 1.9e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 CRG84134.1 - 0.00035 19.6 0.0 0.00048 19.2 0.0 1.1 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 CRG84134.1 - 0.0023 18.0 0.0 0.0038 17.3 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase IlvN PF07991.12 CRG84134.1 - 0.015 14.8 0.0 0.063 12.8 0.0 1.9 3 0 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA PF01408.22 CRG84134.1 - 0.022 15.6 0.0 0.041 14.7 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 CRG84134.1 - 0.073 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CRG84134.1 - 0.14 12.4 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain CMD PF02627.20 CRG84135.1 - 2.2e-23 82.1 0.2 3.5e-23 81.5 0.2 1.3 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family TFX_C PF14601.6 CRG84135.1 - 0.074 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Flu_B_NS1 PF02942.14 CRG84135.1 - 0.14 11.2 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Influenza B non-structural protein (NS1) Fungal_trans PF04082.18 CRG84136.1 - 1.2e-11 44.1 6.1 1.4e-11 44.0 2.4 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 CRG84136.1 - 3.6e-06 27.2 9.0 3.6e-06 27.2 9.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 CRG84136.1 - 1.9e-05 24.8 22.5 0.0028 18.0 4.1 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG84136.1 - 0.012 16.4 25.3 0.071 14.0 3.5 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG84136.1 - 0.11 12.8 6.8 0.19 12.1 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding ATPase-cat_bd PF12156.8 CRG84136.1 - 0.29 11.9 7.1 0.63 10.8 7.1 1.5 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase zf-C2H2_11 PF16622.5 CRG84136.1 - 3.2 7.6 11.5 0.89 9.4 0.9 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type YacG PF03884.14 CRG84136.1 - 5.5 6.8 7.2 27 4.6 7.2 2.3 1 1 0 1 1 1 0 DNA gyrase inhibitor YacG Lactamase_B PF00753.27 CRG84137.1 - 1.7e-06 28.2 4.8 2.8e-06 27.5 4.8 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG84137.1 - 1.4e-05 24.7 0.7 2.2e-05 24.0 0.2 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Sugar_tr PF00083.24 CRG84138.1 - 6.5e-96 321.9 26.5 8.2e-96 321.6 26.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84138.1 - 4e-22 78.6 39.2 8.9e-13 47.9 18.1 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily Aldedh PF00171.22 CRG84139.1 - 2.4e-156 520.9 0.7 2.7e-156 520.7 0.7 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Fungal_trans PF04082.18 CRG84142.1 - 1.1e-21 77.0 0.3 2e-21 76.3 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG84142.1 - 7e-10 38.8 13.6 0.00019 21.7 2.0 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG84142.1 - 1.8e-07 31.3 13.5 2.2e-06 27.8 7.1 2.9 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG84142.1 - 0.0013 19.4 19.4 0.037 14.9 2.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG84142.1 - 0.9 9.9 2.6 0.81 10.0 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4072 PF13284.6 CRG84142.1 - 1.2 9.7 4.0 5.3 7.6 1.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4072) zf-C2H2_11 PF16622.5 CRG84142.1 - 1.6 8.6 8.5 9.9 6.0 1.5 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type Utp8 PF10395.9 CRG84143.1 - 6.9e-08 31.5 0.7 4e-05 22.4 0.0 3.1 2 1 0 2 2 2 2 Utp8 family PSII_Pbs31 PF18240.1 CRG84143.1 - 0.081 13.4 1.0 1.5 9.3 0.0 2.6 2 0 0 2 2 2 0 Photosystem II Psb31 protein AAA PF00004.29 CRG84144.1 - 3.2e-08 34.1 0.0 1.1e-05 25.9 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CRG84144.1 - 8.6e-06 25.8 0.6 0.0018 18.3 0.0 3.3 4 0 0 4 4 4 1 Rad17 P-loop domain AAA_16 PF13191.6 CRG84144.1 - 0.00013 22.4 0.0 0.00033 21.1 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 CRG84144.1 - 0.0021 18.3 0.0 0.011 16.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 CRG84144.1 - 0.0046 17.5 0.4 0.25 11.9 0.0 3.0 2 0 0 2 2 2 1 ABC transporter DUF815 PF05673.13 CRG84144.1 - 0.015 14.5 0.0 0.031 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CRG84144.1 - 0.048 14.2 0.0 0.17 12.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain LOR PF04525.12 CRG84146.1 - 2.8e-07 30.3 0.1 5.4e-07 29.4 0.1 1.4 1 1 0 1 1 1 1 LURP-one-related SAM_2 PF07647.17 CRG84147.1 - 3e-15 56.1 0.0 4.7e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CRG84147.1 - 2.8e-13 50.1 0.0 4.2e-13 49.5 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 CRG84147.1 - 8.5e-13 48.8 0.0 1.7e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 CRG84147.1 - 0.0059 16.6 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Angiomotin_C PF12240.8 CRG84147.1 - 0.12 11.9 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 Angiomotin C terminal Nha1_C PF08619.10 CRG84148.1 - 1.1e-112 377.7 44.0 1.4e-112 377.3 44.0 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 CRG84148.1 - 1e-74 251.6 16.1 1.2e-74 251.4 16.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 CRG84148.1 - 2.1 8.5 4.9 0.97 9.6 0.8 2.4 2 0 0 2 2 2 0 YrhC-like protein DUF21 PF01595.20 CRG84148.1 - 2.8 7.6 5.0 0.73 9.5 1.3 1.9 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain PX PF00787.24 CRG84149.1 - 4.2e-17 62.1 0.2 9.1e-17 61.1 0.2 1.5 1 0 0 1 1 1 1 PX domain Tmemb_cc2 PF10267.9 CRG84149.1 - 0.007 15.6 0.9 0.012 14.8 0.9 1.3 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Prefoldin_3 PF13758.6 CRG84149.1 - 0.028 14.5 2.0 0.041 13.9 0.1 2.2 2 0 0 2 2 2 0 Prefoldin subunit EnY2 PF10163.9 CRG84150.1 - 0.00023 21.5 0.0 0.00044 20.6 0.0 1.4 1 0 0 1 1 1 1 Transcription factor e(y)2 RAP1 PF07218.11 CRG84150.1 - 3.2 5.9 6.7 5.5 5.1 6.7 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Coilin_N PF15862.5 CRG84150.1 - 8.1 6.2 8.1 1.1 9.1 4.0 1.6 2 0 0 2 2 2 0 Coilin N-terminus AAA PF00004.29 CRG84151.1 - 6.3e-97 321.1 0.0 4.7e-47 159.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG84151.1 - 2.8e-22 78.2 1.3 2.9e-12 46.2 0.5 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 CRG84151.1 - 4e-20 71.8 1.6 8.9e-20 70.7 0.7 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 CRG84151.1 - 3.7e-14 53.2 0.0 1.1e-07 32.2 0.0 3.0 3 1 0 3 3 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CRG84151.1 - 3.7e-14 52.8 0.0 6.5e-06 26.0 0.0 3.1 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CRG84151.1 - 3.5e-12 46.7 0.0 2.8e-05 24.3 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 CRG84151.1 - 4.3e-12 46.7 0.0 0.00017 22.0 0.0 4.4 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 CRG84151.1 - 3.9e-11 43.1 0.3 3e-05 24.0 0.1 3.8 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CRG84151.1 - 3.3e-09 36.4 0.7 0.0013 18.0 0.0 3.0 3 1 0 3 3 3 2 TIP49 P-loop domain AAA_22 PF13401.6 CRG84151.1 - 3.9e-09 36.9 0.4 0.03 14.6 0.0 4.1 2 2 2 4 4 4 2 AAA domain CDC48_2 PF02933.17 CRG84151.1 - 1.8e-08 34.0 0.0 4.3e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Mg_chelatase PF01078.21 CRG84151.1 - 6.4e-08 32.2 0.2 0.0061 16.0 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CRG84151.1 - 5e-07 29.3 0.2 0.52 9.6 0.0 3.6 3 0 0 3 3 3 2 KaiC IstB_IS21 PF01695.17 CRG84151.1 - 5.6e-07 29.5 0.0 0.019 14.7 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.6 CRG84151.1 - 6.4e-07 29.1 4.2 0.14 11.7 0.0 4.8 3 2 2 5 5 5 2 AAA domain RNA_helicase PF00910.22 CRG84151.1 - 7.3e-07 29.6 0.0 0.031 14.6 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 CRG84151.1 - 8.2e-07 29.6 0.0 0.029 14.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 CRG84151.1 - 1.1e-06 28.8 0.0 0.017 15.1 0.0 2.8 3 0 0 3 3 2 2 AAA domain Vps4_C PF09336.10 CRG84151.1 - 1.9e-06 27.8 0.1 1.9e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 CRG84151.1 - 5.1e-06 26.1 0.0 0.034 13.6 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 CRG84151.1 - 7.4e-06 25.8 0.0 0.13 11.9 0.0 2.8 3 0 0 3 3 2 2 AAA domain DUF815 PF05673.13 CRG84151.1 - 9.4e-06 25.0 0.0 0.005 16.0 0.0 2.7 3 0 0 3 3 2 1 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 CRG84151.1 - 1.5e-05 24.3 0.1 0.052 12.6 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 CRG84151.1 - 1.9e-05 25.0 0.0 0.18 12.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain Sigma54_activat PF00158.26 CRG84151.1 - 5e-05 23.1 0.0 0.51 10.0 0.0 3.2 2 2 0 2 2 2 2 Sigma-54 interaction domain Bac_DnaA PF00308.18 CRG84151.1 - 5.8e-05 23.0 0.0 0.2 11.4 0.0 2.8 3 0 0 3 3 2 2 Bacterial dnaA protein ABC_tran PF00005.27 CRG84151.1 - 7.5e-05 23.3 0.0 0.28 11.7 0.0 3.4 2 1 0 2 2 2 1 ABC transporter TsaE PF02367.17 CRG84151.1 - 0.00019 21.4 0.0 0.4 10.7 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 CRG84151.1 - 0.00022 21.7 0.0 0.6 10.5 0.0 3.0 3 0 0 3 3 2 1 AAA domain ResIII PF04851.15 CRG84151.1 - 0.00025 21.1 0.0 0.087 12.8 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 CRG84151.1 - 0.00027 20.5 0.4 0.68 9.3 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein NACHT PF05729.12 CRG84151.1 - 0.00034 20.6 0.1 0.18 11.7 0.0 2.8 3 0 0 3 3 3 1 NACHT domain AAA_11 PF13086.6 CRG84151.1 - 0.00036 20.4 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 CRG84151.1 - 0.0004 20.3 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 CRG84151.1 - 0.00059 19.8 0.0 2.3 8.1 0.0 3.6 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 CRG84151.1 - 0.0013 18.5 0.4 1.1 8.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 CRG84151.1 - 0.0019 17.5 0.0 1.4 8.1 0.0 2.2 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Viral_helicase1 PF01443.18 CRG84151.1 - 0.0047 16.7 0.0 0.34 10.6 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 CRG84151.1 - 0.0051 17.2 0.8 5.9 7.2 0.0 3.4 3 1 0 4 4 2 0 AAA domain NB-ARC PF00931.22 CRG84151.1 - 0.0077 15.4 0.0 1.4 8.0 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain UFD1 PF03152.14 CRG84151.1 - 0.009 15.5 0.0 0.075 12.5 0.0 2.0 1 1 1 2 2 2 1 Ubiquitin fusion degradation protein UFD1 NTPase_1 PF03266.15 CRG84151.1 - 0.011 15.7 0.8 2.5 8.0 0.0 3.8 4 0 0 4 4 3 0 NTPase Zeta_toxin PF06414.12 CRG84151.1 - 0.012 14.9 0.0 6.1 6.1 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin IPT PF01745.16 CRG84151.1 - 0.017 14.5 0.0 2.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.14 CRG84151.1 - 0.02 14.1 0.3 0.94 8.6 0.0 2.9 2 2 0 4 4 4 0 KAP family P-loop domain Sigma54_activ_2 PF14532.6 CRG84151.1 - 0.027 14.6 0.0 3.8 7.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Zot PF05707.12 CRG84151.1 - 0.046 13.4 0.0 2 8.0 0.0 3.0 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Cytidylate_kin PF02224.18 CRG84151.1 - 0.051 13.3 0.0 10 5.8 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase AAA_6 PF12774.7 CRG84151.1 - 0.063 12.2 0.1 9 5.2 0.0 2.4 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region eIF-1a PF01176.19 CRG84151.1 - 0.076 12.8 1.6 0.46 10.3 0.7 2.6 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 AFG1_ATPase PF03969.16 CRG84151.1 - 0.078 11.8 0.0 11 4.8 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase T2SSE PF00437.20 CRG84151.1 - 0.1 11.6 0.0 4.1 6.4 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Sec2p PF06428.11 CRG84151.1 - 0.13 12.3 1.3 1.1 9.3 1.3 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p TniB PF05621.11 CRG84151.1 - 0.16 11.3 0.1 22 4.4 0.0 3.3 4 0 0 4 4 4 0 Bacterial TniB protein PEX11 PF05648.14 CRG84154.1 - 2.6e-13 50.0 0.2 1.8e-11 43.9 0.3 2.1 2 0 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) 2TM PF13239.6 CRG84154.1 - 0.044 14.1 0.3 0.11 12.8 0.3 1.7 1 0 0 1 1 1 0 2TM domain DUF4159 PF13709.6 CRG84157.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4159) FAD_binding_3 PF01494.19 CRG84158.1 - 3.5e-16 59.4 0.1 4.6e-06 26.1 0.0 3.0 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 CRG84158.1 - 6.5e-07 29.5 0.1 1.7e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG84158.1 - 0.0006 19.0 0.0 0.0016 17.5 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CRG84158.1 - 0.0016 17.6 0.0 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG84158.1 - 0.0036 16.9 0.0 0.0057 16.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG84158.1 - 0.011 15.0 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 CRG84158.1 - 0.039 13.2 0.0 0.085 12.1 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG84158.1 - 0.057 12.1 0.0 0.083 11.6 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_9 PF13454.6 CRG84158.1 - 0.092 12.7 0.0 0.85 9.6 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG84158.1 - 0.23 10.7 0.0 0.36 10.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase SesA PF17107.5 CRG84159.1 - 9.9e-06 25.7 0.0 1.9e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases VIT PF08487.10 CRG84160.1 - 5.7e-29 100.6 0.1 1.1e-28 99.7 0.1 1.5 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_3 PF13768.6 CRG84160.1 - 6.2e-27 94.4 0.0 1.4e-26 93.3 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 CRG84160.1 - 2.1e-13 50.9 0.0 3.9e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CRG84160.1 - 9.4e-08 32.7 0.0 2e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT_2 PF13757.6 CRG84160.1 - 1.2e-05 25.1 0.0 2.7e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Vault protein inter-alpha-trypsin domain VWA_CoxE PF05762.14 CRG84160.1 - 5.9e-05 22.6 0.0 0.00011 21.7 0.0 1.3 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Aldo_ket_red PF00248.21 CRG84161.1 - 9.3e-46 156.3 0.1 1.4e-41 142.7 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family CNPase PF05881.12 CRG84161.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) Mpv17_PMP22 PF04117.12 CRG84162.1 - 1.5e-12 47.5 2.9 8.2e-12 45.2 1.0 2.3 1 1 1 2 2 2 1 Mpv17 / PMP22 family Cullin_binding PF03556.15 CRG84163.1 - 2.6e-29 102.1 2.6 2.8e-29 102.0 1.5 1.6 2 0 0 2 2 2 1 Cullin binding UPF0113_N PF17833.1 CRG84163.1 - 5.2e-25 87.8 0.1 1.3e-24 86.5 0.1 1.7 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 CRG84163.1 - 2.1e-18 66.3 0.0 3.7e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 UPF0113 PUA domain UBA_4 PF14555.6 CRG84163.1 - 2.4e-11 43.3 0.1 6.6e-11 41.8 0.1 1.7 1 0 0 1 1 1 1 UBA-like domain CRAL_TRIO_N PF03765.15 CRG84163.1 - 0.0043 17.2 0.0 0.011 15.9 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain TAP_C PF03943.13 CRG84163.1 - 0.1 12.2 0.1 0.62 9.7 0.0 2.3 2 1 0 2 2 2 0 TAP C-terminal domain NOC3p PF07540.11 CRG84164.1 - 3.5e-28 97.9 0.9 1.3e-27 96.1 0.9 2.1 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 CRG84164.1 - 2.7e-25 89.4 3.9 3.7e-25 88.9 0.0 2.7 3 0 0 3 3 3 1 CBF/Mak21 family DUF1349 PF07081.11 CRG84166.1 - 6.9e-21 74.8 0.0 9.2e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Aldo_ket_red PF00248.21 CRG84167.1 - 1.2e-65 221.7 0.0 1.5e-65 221.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NTase_sub_bind PF08780.11 CRG84167.1 - 0.022 14.7 0.3 0.051 13.5 0.3 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like MRP-L46 PF11788.8 CRG84168.1 - 2.9e-38 131.3 0.7 4.6e-38 130.6 0.7 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 CRG84168.1 - 0.00043 20.3 0.0 0.00089 19.3 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain COX_ARM PF06481.14 CRG84168.1 - 0.031 14.2 0.1 0.065 13.1 0.1 1.5 1 0 0 1 1 1 0 COX Aromatic Rich Motif CAF1 PF04857.20 CRG84169.1 - 8.9e-73 245.2 0.0 1.2e-72 244.9 0.0 1.1 1 0 0 1 1 1 1 CAF1 family ribonuclease SBF_like PF13593.6 CRG84170.1 - 2e-94 316.4 19.1 2.7e-94 316.0 19.1 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Mem_trans PF03547.18 CRG84170.1 - 0.032 12.6 0.0 0.032 12.6 0.0 2.4 3 0 0 3 3 3 0 Membrane transport protein Macoilin PF09726.9 CRG84170.1 - 0.097 11.2 7.3 0.16 10.5 7.3 1.3 1 0 0 1 1 1 0 Macoilin family TFIIF_alpha PF05793.12 CRG84170.1 - 0.56 8.7 16.7 0.82 8.2 16.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Pol_alpha_B_N PF08418.10 CRG84170.1 - 1.2 9.0 8.1 2.4 8.1 8.1 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Mito_carr PF00153.27 CRG84171.1 - 2.3e-67 223.0 0.8 5.2e-23 80.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Sod_Cu PF00080.20 CRG84172.1 - 1.5e-45 154.9 1.7 1.8e-45 154.6 1.7 1.1 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) BppL_N PF18338.1 CRG84172.1 - 0.039 13.7 0.1 0.21 11.4 0.2 2.2 2 0 0 2 2 2 0 Lower baseplate protein N-terminal domain NMO PF03060.15 CRG84173.1 - 3.8e-30 105.4 0.3 6.9e-23 81.6 0.1 2.4 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 CRG84173.1 - 3.5e-07 29.6 0.1 4.8e-07 29.1 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CRG84173.1 - 0.00017 20.9 0.0 0.00028 20.2 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG84173.1 - 0.0092 15.0 0.0 0.57 9.1 0.1 2.2 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain Tautomerase_2 PF14552.6 CRG84174.1 - 1.9e-29 101.6 0.0 2.7e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase PF01361.21 CRG84174.1 - 9.5e-14 51.1 0.0 3.6e-07 30.0 0.0 2.2 1 1 0 2 2 2 2 Tautomerase enzyme DUF1548 PF07579.11 CRG84174.1 - 0.02 15.2 0.3 0.32 11.3 0.1 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1548) Sugar_tr PF00083.24 CRG84175.1 - 6.8e-32 110.9 20.1 5e-30 104.8 14.4 2.9 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG84175.1 - 2.7e-30 105.5 25.5 5.8e-30 104.4 25.4 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG84175.1 - 0.023 13.1 3.4 0.41 9.0 0.2 2.2 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) BatA PF07584.11 CRG84175.1 - 7.5 7.0 7.7 94 3.5 0.0 3.9 3 1 0 3 3 3 0 Aerotolerance regulator N-terminal Sacchrp_dh_NADP PF03435.18 CRG84177.1 - 6.1e-16 58.9 0.0 9.1e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RRM_1 PF00076.22 CRG84180.1 - 9.3e-12 44.6 0.0 1.9e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 CRG84181.1 - 4.3e-55 187.0 31.0 6.2e-49 166.8 18.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CRG84181.1 - 6e-08 31.5 4.3 6e-08 31.5 4.3 2.3 3 0 0 3 3 3 1 Transmembrane secretion effector OATP PF03137.20 CRG84181.1 - 8.8e-08 30.9 4.7 0.00014 20.3 1.4 3.5 2 1 2 4 4 4 3 Organic Anion Transporter Polypeptide (OATP) family Flavi_NS4A PF01350.17 CRG84181.1 - 0.0037 17.2 1.1 0.64 9.9 0.1 2.8 2 0 0 2 2 2 2 Flavivirus non-structural protein NS4A Folate_carrier PF01770.18 CRG84181.1 - 0.007 15.1 0.2 0.014 14.1 0.0 1.6 2 0 0 2 2 2 1 Reduced folate carrier MFS_1_like PF12832.7 CRG84181.1 - 0.27 10.1 14.3 0.013 14.4 2.5 3.2 1 1 2 3 3 3 0 MFS_1 like family Sec2p PF06428.11 CRG84182.1 - 1.5e-10 40.9 11.6 1.5e-10 40.9 11.6 1.9 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Cluap1 PF10234.9 CRG84182.1 - 0.00058 19.3 3.3 0.00058 19.3 3.3 1.6 2 0 0 2 2 2 1 Clusterin-associated protein-1 Rop-like PF05082.13 CRG84182.1 - 0.023 14.5 0.9 0.084 12.7 0.0 2.3 2 1 0 2 2 2 0 Rop-like DUF2802 PF10975.8 CRG84182.1 - 0.27 11.4 12.3 1.3 9.2 0.5 3.4 2 2 0 3 3 3 0 Protein of unknown function (DUF2802) Jnk-SapK_ap_N PF09744.9 CRG84182.1 - 0.31 11.3 17.5 0.22 11.8 11.0 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 CRG84182.1 - 0.46 9.8 8.9 1.2 8.4 5.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SlyX PF04102.12 CRG84182.1 - 0.6 10.8 0.1 0.6 10.8 0.1 4.1 4 1 0 4 4 4 0 SlyX FAM76 PF16046.5 CRG84182.1 - 2 7.7 8.1 3.3 7.0 8.0 1.4 1 1 0 1 1 1 0 FAM76 protein Spc7 PF08317.11 CRG84182.1 - 5.7 5.7 14.0 1 8.2 8.8 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Heme_oxygenase PF01126.20 CRG84184.1 - 3.3e-12 46.6 0.0 1.7e-11 44.3 0.0 1.8 1 1 0 1 1 1 1 Heme oxygenase MFS_1 PF07690.16 CRG84185.1 - 9.9e-43 146.4 39.1 9.9e-43 146.4 39.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84185.1 - 4.9e-11 42.2 7.6 4.9e-11 42.2 7.6 2.2 3 0 0 3 3 3 1 Sugar (and other) transporter PHD PF00628.29 CRG84186.1 - 6.1e-10 38.8 6.6 6.1e-10 38.8 6.6 2.6 2 0 0 2 2 2 1 PHD-finger zf-rbx1 PF12678.7 CRG84186.1 - 1.6e-08 34.7 0.6 1.6e-08 34.7 0.6 2.7 3 0 0 3 3 3 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CRG84186.1 - 3.3e-08 33.7 1.6 3.3e-08 33.7 1.6 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG84186.1 - 1.3e-06 28.1 1.7 1.3e-06 28.1 1.7 2.5 4 0 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG84186.1 - 1.2e-05 25.1 0.2 1.2e-05 25.1 0.2 2.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG84186.1 - 0.00012 21.9 0.1 0.00012 21.9 0.1 2.9 4 0 0 4 4 3 1 zinc-RING finger domain PHD_2 PF13831.6 CRG84186.1 - 0.00024 20.6 2.3 0.00024 20.6 2.3 2.0 2 0 0 2 2 2 1 PHD-finger Prok-RING_4 PF14447.6 CRG84186.1 - 0.00035 20.4 1.0 0.00035 20.4 1.0 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CRG84186.1 - 0.00036 20.2 0.4 0.02 14.6 0.1 2.8 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 CRG84186.1 - 0.00099 19.1 0.1 0.00099 19.1 0.1 1.8 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 CRG84186.1 - 0.0023 17.8 0.6 0.0023 17.8 0.6 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG84186.1 - 0.0061 16.6 1.1 0.0061 16.6 1.1 2.9 3 1 0 3 3 3 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CRG84186.1 - 0.031 13.9 0.7 0.031 13.9 0.7 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DZR PF12773.7 CRG84186.1 - 0.27 11.3 6.1 5.4 7.1 2.1 2.9 1 1 1 2 2 2 0 Double zinc ribbon zf-UDP PF14569.6 CRG84186.1 - 0.29 11.3 6.9 0.49 10.5 2.1 2.5 2 0 0 2 2 2 0 Zinc-binding RING-finger CDC24_OB3 PF17244.2 CRG84186.1 - 0.49 10.1 1.8 2.5 7.8 0.3 2.2 1 1 0 2 2 2 0 Cell division control protein 24, OB domain 3 Prok-RING_1 PF14446.6 CRG84186.1 - 4.7 7.2 11.7 1.2 9.1 3.5 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-met PF12874.7 CRG84186.1 - 9 6.8 5.7 51 4.5 1.0 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type FYVE_2 PF02318.16 CRG84186.1 - 9.9 6.4 6.5 7.9 6.7 2.1 2.8 2 1 0 2 2 2 0 FYVE-type zinc finger Cofilin_ADF PF00241.20 CRG84189.1 - 1.7e-26 92.4 0.0 1.5e-17 63.5 0.0 2.3 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein DUF5553 PF17707.1 CRG84189.1 - 0.029 13.8 0.4 0.37 10.2 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5553) PHF5 PF03660.14 CRG84190.1 - 7.6e-53 177.1 9.7 8.5e-53 176.9 9.7 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 CRG84190.1 - 0.13 10.1 4.7 0.13 10.1 4.7 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 CRG84190.1 - 1.3 9.1 14.7 2.3 8.3 1.3 3.0 1 1 1 2 2 2 0 Double zinc ribbon Pinin_SDK_memA PF04696.13 CRG84191.1 - 2e-29 102.3 11.9 2e-29 102.3 11.9 2.9 2 1 1 3 3 3 1 pinin/SDK/memA/ protein conserved region RSB_motif PF16294.5 CRG84191.1 - 0.019 15.3 5.1 0.019 15.3 5.1 4.2 2 1 2 4 4 4 0 RNSP1-SAP18 binding (RSB) motif Abhydrolase_1 PF00561.20 CRG84193.1 - 4.6e-21 75.6 0.4 3.4e-20 72.8 0.4 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG84193.1 - 4.2e-13 50.4 0.1 5.6e-13 50.0 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG84193.1 - 2.4e-09 36.8 0.0 1.6e-08 34.1 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 CRG84193.1 - 0.0063 16.4 0.0 0.015 15.1 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_4 PF08386.10 CRG84193.1 - 0.0077 16.3 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein MFS_1 PF07690.16 CRG84194.1 - 6.9e-16 58.1 53.9 3e-10 39.5 19.4 3.5 2 1 2 4 4 4 3 Major Facilitator Superfamily TRI12 PF06609.13 CRG84194.1 - 2e-10 39.7 23.4 3e-10 39.1 23.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GMC_oxred_N PF00732.19 CRG84195.1 - 1.4e-63 215.1 0.0 2e-63 214.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG84195.1 - 1.3e-31 110.0 0.0 2.4e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CRG84195.1 - 2.2e-05 23.7 1.0 3.2e-05 23.1 1.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 CRG84195.1 - 0.0016 17.7 0.2 0.0036 16.6 0.2 1.5 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 CRG84195.1 - 0.0048 16.0 1.8 0.011 14.8 1.5 1.7 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 CRG84195.1 - 0.019 13.8 0.3 0.026 13.4 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase DAO PF01266.24 CRG84195.1 - 0.03 13.9 1.4 0.068 12.7 0.9 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG84195.1 - 0.048 13.9 0.3 0.12 12.6 0.3 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Peptidase_S8 PF00082.22 CRG84196.1 - 2.6e-15 56.5 3.0 2.6e-15 56.5 3.0 3.8 3 1 0 3 3 3 1 Subtilase family Tim17 PF02466.19 CRG84197.1 - 0.015 15.7 1.2 0.28 11.6 1.2 2.2 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Osmo_CC PF08946.10 CRG84197.1 - 0.27 11.5 1.5 0.5 10.7 1.5 1.4 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Fmp27 PF10344.9 CRG84198.1 - 1.2e-228 761.5 0.0 2.2e-228 760.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Apt1 PF10351.9 CRG84198.1 - 9.4e-194 644.7 0.2 9.4e-194 644.7 0.2 3.5 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 CRG84198.1 - 2.9e-173 577.2 8.4 2.5e-172 574.1 6.0 2.4 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 CRG84198.1 - 8.6e-54 181.9 0.0 4.7e-53 179.5 0.0 2.2 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 CRG84198.1 - 1.6e-52 177.6 0.0 3.6e-52 176.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 CRG84198.1 - 1.4e-32 112.5 0.1 2.6e-31 108.4 0.0 3.2 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain Serine_rich PF08824.10 CRG84198.1 - 4.2 7.4 5.3 0.87 9.6 0.0 2.5 3 0 0 3 3 3 0 Serine rich protein interaction domain Pro-kuma_activ PF09286.11 CRG84200.1 - 4.7e-48 163.1 0.0 4.8e-47 159.8 0.0 2.1 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG84200.1 - 0.0096 15.2 0.0 0.022 14.0 0.0 1.5 1 1 0 1 1 1 1 Subtilase family Oxidored_FMN PF00724.20 CRG84201.1 - 1.8e-35 122.8 0.0 2.7e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Ysc84 PF04366.12 CRG84201.1 - 2.4e-30 104.9 0.4 5.7e-30 103.7 0.1 1.8 2 0 0 2 2 2 1 Las17-binding protein actin regulator FMN_dh PF01070.18 CRG84201.1 - 0.0026 16.9 0.0 0.005 15.9 0.0 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Dus PF01207.17 CRG84201.1 - 0.028 13.5 0.0 0.08 12.0 0.0 1.8 2 1 0 2 2 2 0 Dihydrouridine synthase (Dus) MTHFR PF02219.17 CRG84201.1 - 0.04 13.2 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 Methylenetetrahydrofolate reductase FA_hydroxylase PF04116.13 CRG84202.1 - 5.6e-23 81.8 14.5 5.6e-23 81.8 14.5 2.3 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Cellulase PF00150.18 CRG84203.1 - 3.8e-20 72.5 2.5 5.5e-20 71.9 2.5 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) FAD_binding_3 PF01494.19 CRG84204.1 - 2.7e-22 79.5 0.0 8.9e-22 77.8 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG84204.1 - 1.1e-11 44.5 0.1 7.3e-05 22.1 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG84204.1 - 2.4e-09 37.2 1.4 6.5e-06 26.0 0.4 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG84204.1 - 3e-07 29.9 0.4 1.4e-06 27.7 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 CRG84204.1 - 7.7e-07 28.2 0.5 0.00013 20.8 0.2 2.1 2 0 0 2 2 2 2 HI0933-like protein Trp_halogenase PF04820.14 CRG84204.1 - 8.5e-07 28.2 0.2 0.002 17.1 0.1 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 CRG84204.1 - 1.1e-06 29.0 0.1 0.00027 21.4 0.1 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG84204.1 - 3.9e-06 27.0 0.1 2.3e-05 24.5 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG84204.1 - 5.6e-06 25.6 0.1 0.0071 15.4 0.1 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_oxidored PF12831.7 CRG84204.1 - 8e-06 25.5 0.2 7.2e-05 22.3 0.2 2.2 2 1 0 2 2 2 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CRG84204.1 - 0.00053 19.4 0.1 0.079 12.2 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase AlaDh_PNT_C PF01262.21 CRG84204.1 - 0.0013 18.1 0.0 0.0023 17.3 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 CRG84204.1 - 0.0017 17.5 0.6 0.011 14.9 0.2 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 CRG84204.1 - 0.0018 18.3 0.3 0.23 11.5 0.1 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding NdhN PF11909.8 CRG84204.1 - 0.0038 16.9 0.0 0.0068 16.1 0.0 1.3 1 0 0 1 1 1 1 NADH-quinone oxidoreductase cyanobacterial subunit N Pyr_redox_3 PF13738.6 CRG84204.1 - 0.0055 16.0 0.1 0.016 14.5 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG84204.1 - 0.0091 15.3 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 1 Thi4 family ApbA PF02558.16 CRG84204.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA adh_short PF00106.25 CRG84205.1 - 2.2e-22 79.5 0.0 1.4e-17 63.8 0.0 2.5 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG84205.1 - 6.2e-11 42.3 0.0 4.2e-09 36.3 0.0 2.4 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG84205.1 - 1.2e-05 25.3 0.0 2.4e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG84205.1 - 0.012 15.1 0.0 0.031 13.7 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Csm1_B PF18211.1 CRG84205.1 - 0.037 13.8 0.0 0.097 12.5 0.0 1.7 1 0 0 1 1 1 0 Csm1 subunit domain B PPC PF04151.15 CRG84205.1 - 0.14 13.3 0.1 0.34 12.0 0.1 1.7 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain Fungal_trans PF04082.18 CRG84206.1 - 6.8e-06 25.3 0.3 1.6e-05 24.1 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain AhpC-TSA PF00578.21 CRG84207.1 - 6.7e-25 87.4 0.0 9.5e-25 86.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CRG84207.1 - 1e-17 64.2 0.0 1.2e-16 60.7 0.0 2.0 1 1 0 1 1 1 1 Redoxin DUF899 PF05988.12 CRG84207.1 - 3.9e-06 26.5 0.0 5.3e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) Thioredoxin_2 PF13098.6 CRG84207.1 - 0.014 15.9 0.0 0.024 15.1 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin PF00085.20 CRG84207.1 - 0.023 14.7 0.0 0.061 13.3 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin Peptidase_C14 PF00656.22 CRG84208.1 - 5.6e-51 173.9 0.0 8.4e-51 173.3 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Zn_clus PF00172.18 CRG84209.1 - 1.3e-08 34.8 10.1 2.3e-08 34.0 10.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG84210.1 - 1.7e-31 109.4 38.2 1.7e-31 109.4 38.2 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84210.1 - 1.9e-11 43.5 7.6 1.9e-11 43.5 7.6 2.7 1 1 3 4 4 4 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84211.1 - 9e-10 38.0 23.2 9e-10 38.0 23.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84211.1 - 0.00016 20.7 9.5 0.00026 20.0 9.5 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter UNC-93 PF05978.16 CRG84211.1 - 0.00021 21.1 4.7 0.00021 21.1 4.7 1.9 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 Epimerase PF01370.21 CRG84213.1 - 2.6e-17 63.1 0.0 4.6e-17 62.3 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG84213.1 - 2.9e-13 49.5 0.0 5.7e-13 48.5 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG84213.1 - 1.4e-09 37.8 0.9 1.5e-08 34.5 0.2 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG84213.1 - 3.2e-07 29.8 0.0 7.5e-07 28.6 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 CRG84213.1 - 5.1e-05 22.6 0.7 7.4e-05 22.0 0.7 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CRG84213.1 - 5.9e-05 23.0 0.7 0.0001 22.2 0.1 1.8 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 CRG84213.1 - 0.00058 19.8 0.5 0.001 19.0 0.5 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CRG84213.1 - 0.00062 19.3 0.3 0.0061 16.0 0.2 2.1 2 0 0 2 2 2 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CRG84213.1 - 0.0041 16.3 0.2 0.0064 15.6 0.2 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 CRG84213.1 - 0.028 14.0 0.1 0.22 11.1 0.1 2.1 2 0 0 2 2 2 0 NmrA-like family Gamma_PGA_hydro PF05908.11 CRG84213.1 - 0.11 11.8 0.1 0.19 11.1 0.1 1.3 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase MerR-DNA-bind PF09278.11 CRG84213.1 - 0.14 12.7 0.0 0.57 10.8 0.0 1.9 2 0 0 2 2 2 0 MerR, DNA binding Amidohydro_2 PF04909.14 CRG84216.1 - 2.1e-12 47.4 0.1 3.1e-12 46.9 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase Fungal_trans PF04082.18 CRG84216.1 - 1.6e-06 27.4 0.1 2.4e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phage_holin_2_1 PF04971.12 CRG84216.1 - 0.093 12.7 0.3 12 6.0 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage P21 holin S RraA-like PF03737.15 CRG84218.1 - 6.7e-34 117.2 0.0 8.4e-34 116.9 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA Aconitase PF00330.20 CRG84219.1 - 9.1e-129 430.4 0.0 1.3e-128 429.9 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CRG84219.1 - 2.2e-34 118.6 0.0 3.4e-34 118.0 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Methyltr_RsmF_N PF17125.5 CRG84219.1 - 0.08 13.4 0.0 1.2 9.7 0.0 2.7 3 0 0 3 3 3 0 N-terminal domain of 16S rRNA methyltransferase RsmF DUF521 PF04412.13 CRG84219.1 - 0.092 11.4 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) FAD_binding_3 PF01494.19 CRG84220.1 - 6.7e-21 74.9 0.0 8.8e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG84220.1 - 2.1e-05 23.9 0.0 0.029 13.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG84220.1 - 8e-05 22.4 0.0 0.0021 17.7 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG84220.1 - 0.00011 22.3 0.0 0.00026 21.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG84220.1 - 0.00012 22.6 0.1 0.0021 18.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG84220.1 - 0.018 14.3 0.2 0.74 9.0 0.1 2.2 2 0 0 2 2 2 0 Thi4 family AlaDh_PNT_C PF01262.21 CRG84220.1 - 0.043 13.1 0.1 0.065 12.5 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CRG84220.1 - 0.18 10.9 0.0 0.34 10.0 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CRG84220.1 - 0.19 10.4 0.0 18 3.9 0.0 3.1 4 0 0 4 4 4 0 HI0933-like protein Trp_halogenase PF04820.14 CRG84220.1 - 0.26 10.1 1.2 6 5.6 0.3 2.5 2 1 1 3 3 3 0 Tryptophan halogenase Fungal_trans PF04082.18 CRG84221.1 - 7.2e-14 51.5 0.0 6.5e-13 48.3 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain AP_endonuc_2 PF01261.24 CRG84221.1 - 0.15 11.5 0.0 5.7 6.3 0.0 3.0 2 1 1 4 4 4 0 Xylose isomerase-like TIM barrel p450 PF00067.22 CRG84223.1 - 1.8e-54 185.2 0.0 2.4e-54 184.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PI-PLC-X PF00388.19 CRG84224.1 - 5.9e-07 29.2 0.0 1.1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain DUF1586 PF07625.11 CRG84224.1 - 0.063 13.3 4.8 3.1 7.9 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1586) His_Phos_2 PF00328.22 CRG84225.1 - 1.1e-05 25.0 0.0 0.0046 16.4 0.0 2.1 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) GMC_oxred_N PF00732.19 CRG84226.1 - 3.8e-54 184.1 0.0 4.9e-54 183.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG84226.1 - 1.2e-35 123.2 0.0 2e-35 122.4 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CRG84226.1 - 0.00061 20.0 0.1 0.0019 18.4 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG84226.1 - 0.014 14.6 0.1 0.06 12.6 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG84226.1 - 0.02 13.9 0.0 0.035 13.2 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 CRG84226.1 - 0.027 13.7 0.0 0.05 12.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CRG84226.1 - 0.035 13.4 0.0 0.36 10.0 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG84226.1 - 0.037 13.1 0.1 0.24 10.4 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain DAO PF01266.24 CRG84226.1 - 0.055 13.0 0.4 0.26 10.8 0.1 2.2 2 1 1 3 3 3 0 FAD dependent oxidoreductase Fungal_lectin_2 PF18647.1 CRG84227.1 - 0.019 15.4 0.0 0.081 13.4 0.0 2.0 2 0 0 2 2 2 0 Alpha-galactosyl-binding fungal lectin SAP130_C PF16014.5 CRG84227.1 - 2.3 7.2 15.1 8.5 5.4 0.4 2.1 1 1 1 2 2 2 0 Histone deacetylase complex subunit SAP130 C-terminus DLH PF01738.18 CRG84228.1 - 3.2e-10 40.0 0.0 4.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CRG84228.1 - 0.044 13.2 0.0 0.27 10.7 0.0 1.9 1 1 1 2 2 2 0 Prolyl oligopeptidase family Acyl-CoA_dh_M PF02770.19 CRG84228.1 - 0.12 12.6 0.0 0.31 11.2 0.0 1.7 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, middle domain Fungal_trans_2 PF11951.8 CRG84230.1 - 3.3e-07 29.5 5.2 6e-07 28.6 5.2 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain MIT PF04212.18 CRG84230.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain p450 PF00067.22 CRG84231.1 - 1.6e-56 192.0 0.0 2.4e-56 191.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 YMF19 PF02326.15 CRG84231.1 - 0.2 12.5 2.0 0.48 11.2 2.0 1.6 1 0 0 1 1 1 0 Plant ATP synthase F0 MHYT PF03707.16 CRG84231.1 - 4.3 7.6 7.8 2.7 8.2 4.3 2.4 1 1 1 2 2 2 0 Bacterial signalling protein N terminal repeat Methyltransf_23 PF13489.6 CRG84232.1 - 2.2e-20 73.1 0.0 3.2e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84232.1 - 2.3e-10 41.0 0.0 9.3e-10 39.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG84232.1 - 2.6e-10 40.3 0.0 4.2e-09 36.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG84232.1 - 2.1e-07 31.6 0.0 1.6e-06 28.8 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG84232.1 - 3.1e-07 30.9 0.0 1.2e-06 29.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain FtsJ PF01728.19 CRG84232.1 - 0.0047 17.1 0.0 0.025 14.7 0.0 1.9 1 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_16 PF10294.9 CRG84232.1 - 0.0053 16.5 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_2 PF00891.18 CRG84232.1 - 0.015 14.6 0.0 0.043 13.1 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain MTS PF05175.14 CRG84232.1 - 0.032 13.8 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 CRG84232.1 - 0.039 13.4 0.0 0.061 12.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 CRG84232.1 - 0.065 12.7 1.0 0.086 12.3 0.0 1.7 2 0 0 2 2 1 0 Putative methyltransferase DUF938 PF06080.12 CRG84232.1 - 0.2 11.4 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Pyridoxal_deC PF00282.19 CRG84233.1 - 1.3e-64 218.3 0.0 1.8e-64 217.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 CRG84233.1 - 1.1e-11 44.6 0.0 2.1e-11 43.6 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CRG84233.1 - 1.9e-07 30.7 0.0 2.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase SepSecS PF05889.13 CRG84233.1 - 7.4e-06 24.9 0.0 1e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Aminotran_5 PF00266.19 CRG84233.1 - 8.5e-06 25.0 0.0 1.2e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG84233.1 - 0.087 12.1 0.1 0.14 11.4 0.1 1.5 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family HLH PF00010.26 CRG84234.1 - 1.1e-08 34.8 0.2 2.7e-08 33.6 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TAL_FSA PF00923.19 CRG84235.1 - 1.5e-32 113.1 0.0 2.4e-32 112.4 0.0 1.3 2 0 0 2 2 2 1 Transaldolase/Fructose-6-phosphate aldolase Sugar_tr PF00083.24 CRG84237.1 - 6e-87 292.4 25.1 7.6e-87 292.0 25.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84237.1 - 7.1e-15 54.8 52.5 3e-08 33.0 22.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_S17e PF00833.18 CRG84238.1 - 4.4e-59 197.7 0.4 5.4e-59 197.5 0.4 1.1 1 0 0 1 1 1 1 Ribosomal S17 Fungal_trans PF04082.18 CRG84239.1 - 9e-13 47.8 0.3 1.6e-12 47.0 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84239.1 - 2.8e-10 40.2 4.4 7.4e-10 38.8 4.4 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MinC_N PF05209.13 CRG84239.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain CDO_I PF05995.12 CRG84240.1 - 7.3e-39 132.8 0.1 9.9e-39 132.4 0.1 1.1 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 CRG84240.1 - 0.00044 19.8 0.0 0.0006 19.3 0.0 1.3 1 0 0 1 1 1 1 PCO_ADO Exo_endo_phos PF03372.23 CRG84241.1 - 2.1e-06 27.5 4.0 1.1e-05 25.1 4.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Peptidase_A4 PF01828.17 CRG84242.1 - 1.4e-69 233.8 16.1 1.7e-69 233.5 16.1 1.1 1 0 0 1 1 1 1 Peptidase A4 family Big_8 PF17961.1 CRG84242.1 - 0.87 9.8 6.7 4.1 7.6 0.9 2.7 2 1 1 3 3 3 0 Bacterial Ig domain DUF2786 PF10979.8 CRG84243.1 - 1.2e-11 44.3 0.4 1.2e-11 44.3 0.4 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2786) Pkinase PF00069.25 CRG84244.1 - 3.8e-56 190.4 0.0 5.2e-56 189.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84244.1 - 2.1e-42 145.2 0.0 3e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG84244.1 - 3.5e-07 29.9 0.0 5.8e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CRG84244.1 - 0.00031 19.6 0.0 0.00091 18.1 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 CRG84244.1 - 0.012 15.5 0.1 0.075 12.9 0.1 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CRG84244.1 - 0.024 14.0 0.1 0.048 13.0 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CRG84244.1 - 0.052 13.2 0.0 0.13 11.8 0.0 1.7 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 CRG84244.1 - 0.11 12.1 0.1 0.93 9.0 0.1 2.3 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Pro-kuma_activ PF09286.11 CRG84245.1 - 1.6e-44 151.7 0.0 8.9e-44 149.2 0.0 2.1 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain ACC_epsilon PF13822.6 CRG84245.1 - 0.065 13.9 4.4 0.14 12.8 4.4 1.6 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Aminotran_1_2 PF00155.21 CRG84246.1 - 1.7e-14 53.8 0.0 2.2e-14 53.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 CRG84246.1 - 0.0004 19.3 0.0 0.00073 18.4 0.0 1.3 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Beta_elim_lyase PF01212.21 CRG84246.1 - 0.041 13.2 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Dak1 PF02733.17 CRG84247.1 - 1.7e-110 368.8 0.1 2.6e-110 368.2 0.1 1.3 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 CRG84247.1 - 2.7e-37 128.3 0.4 1.5e-35 122.6 0.0 2.4 2 0 0 2 2 2 2 DAK2 domain Thioredoxin PF00085.20 CRG84249.1 - 6.7e-28 96.7 0.0 8.3e-28 96.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CRG84249.1 - 1.2e-08 35.3 0.1 4e-08 33.7 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CRG84249.1 - 1.8e-06 28.2 0.0 0.00026 21.2 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 CRG84249.1 - 6.6e-06 26.1 0.1 2.8e-05 24.0 0.1 1.8 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 CRG84249.1 - 0.00018 21.6 0.0 0.00031 20.9 0.0 1.4 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CRG84249.1 - 0.00028 20.6 0.1 0.01 15.6 0.0 2.0 1 1 1 2 2 2 2 Redoxin OST3_OST6 PF04756.13 CRG84249.1 - 0.00076 18.9 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 CRG84249.1 - 0.0016 18.2 0.1 0.0018 18.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 CRG84249.1 - 0.015 15.2 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TraF PF13728.6 CRG84249.1 - 0.14 12.0 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein TPP_enzyme_N PF02776.18 CRG84251.1 - 2.4e-30 105.4 0.1 1.3e-28 99.8 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG84251.1 - 8.9e-21 74.3 0.0 2.4e-20 72.9 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG84251.1 - 7.4e-13 48.4 0.0 1.1e-11 44.6 0.0 2.6 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain MFS_1 PF07690.16 CRG84253.1 - 0.00044 19.3 13.1 0.00051 19.1 13.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily HalX PF08663.10 CRG84256.1 - 0.012 15.9 1.7 0.019 15.3 0.6 1.9 2 0 0 2 2 2 0 HalX domain Laminin_I PF06008.14 CRG84256.1 - 0.073 12.8 0.9 0.12 12.1 0.9 1.2 1 0 0 1 1 1 0 Laminin Domain I Telomere_reg-2 PF10193.9 CRG84258.1 - 3.7e-30 104.6 0.0 8.2e-30 103.5 0.0 1.6 1 0 0 1 1 1 1 Telomere length regulation protein ThiF PF00899.21 CRG84260.1 - 2.7e-60 203.8 0.0 4e-60 203.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 CRG84260.1 - 2.8e-29 101.1 0.1 5.1e-29 100.3 0.1 1.4 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 CRG84260.1 - 0.00028 21.0 0.7 0.0014 18.7 0.0 2.3 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG84260.1 - 0.024 14.9 0.1 0.36 11.1 0.2 2.7 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain PglD_N PF17836.1 CRG84260.1 - 0.035 14.8 0.9 0.12 13.0 0.4 2.1 1 1 1 2 2 2 0 PglD N-terminal domain Pyr_redox PF00070.27 CRG84260.1 - 0.052 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ecm33 PF12454.8 CRG84260.1 - 0.07 13.3 0.7 0.15 12.2 0.7 1.5 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein E1_UFD PF09358.10 CRG84260.1 - 0.082 13.6 0.0 0.2 12.4 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin fold domain NAD_binding_7 PF13241.6 CRG84260.1 - 0.15 12.5 0.1 0.46 10.9 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding UBA_e1_thiolCys PF10585.9 CRG84260.1 - 0.24 11.3 1.9 9.9 6.0 0.0 2.3 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site RNA_pol_A_bac PF01000.26 CRG84261.1 - 3.6e-26 91.8 0.0 7.4e-26 90.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CRG84261.1 - 5.7e-20 70.5 0.0 8.4e-20 70.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Complex1_49kDa PF00346.19 CRG84262.1 - 1.6e-124 414.4 0.0 2.3e-124 413.9 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 CRG84262.1 - 0.0094 14.9 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Nickel-dependent hydrogenase UQ_con PF00179.26 CRG84263.1 - 3.5e-25 88.3 0.1 4e-25 88.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CRG84263.1 - 8e-05 22.4 0.0 0.00013 21.7 0.0 1.4 1 1 1 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 CRG84263.1 - 0.059 13.7 0.1 0.084 13.2 0.1 1.4 1 0 0 1 1 1 0 RWD domain DUF4305 PF14146.6 CRG84267.1 - 0.028 14.6 0.0 0.1 12.8 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4305) Lipase_GDSL PF00657.22 CRG84268.1 - 8.3e-14 52.0 0.0 1.3e-13 51.4 0.0 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CRG84268.1 - 8.2e-06 26.3 0.4 8.2e-06 26.3 0.4 1.6 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Toxin_35 PF10530.9 CRG84269.1 - 0.0011 18.9 1.4 0.0019 18.1 1.4 1.4 1 0 0 1 1 1 1 Toxin with inhibitor cystine knot ICK or Knottin scaffold Toxin_12 PF07740.12 CRG84269.1 - 0.042 14.6 3.8 0.062 14.0 3.8 1.3 1 0 0 1 1 1 0 Ion channel inhibitory toxin Conotoxin PF02950.17 CRG84269.1 - 0.35 11.9 2.8 0.67 11.0 2.8 1.5 1 1 0 1 1 1 0 Conotoxin Methyltransf_3 PF01596.17 CRG84270.1 - 1.6e-19 69.9 0.0 2e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CRG84270.1 - 2e-12 48.0 0.1 3.1e-12 47.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84270.1 - 1.7e-06 28.6 0.1 2.6e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG84270.1 - 0.00022 21.8 0.0 0.00034 21.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CRG84270.1 - 0.0013 18.5 0.0 0.0018 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 CRG84270.1 - 0.0029 17.5 0.0 0.0076 16.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 CRG84270.1 - 0.0083 15.8 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 CRG84270.1 - 0.05 13.2 0.0 0.066 12.8 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase BCDHK_Adom3 PF10436.9 CRG84271.1 - 3.4e-45 153.8 0.0 4.7e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CRG84271.1 - 4.1e-13 49.8 0.0 2.5e-12 47.3 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 CRG84271.1 - 0.023 14.7 0.0 0.13 12.2 0.0 2.0 1 1 0 1 1 1 0 Histidine kinase-like ATPase domain Inhibitor_I9 PF05922.16 CRG84272.1 - 0.0015 19.2 0.2 0.0017 19.0 0.2 1.1 1 0 0 1 1 1 1 Peptidase inhibitor I9 DUF5611 PF18446.1 CRG84272.1 - 0.079 13.8 0.1 0.093 13.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5611) DUF1892 PF08987.10 CRG84272.1 - 0.083 13.1 0.0 0.084 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1892) DUF1989 PF09347.10 CRG84273.1 - 4e-63 212.0 0.0 5.8e-63 211.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Porphobil_deam PF01379.20 CRG84274.1 - 2.9e-71 239.2 0.0 4.1e-71 238.7 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 CRG84274.1 - 1.5e-17 63.7 0.1 2.7e-17 62.9 0.1 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain TAP42 PF04177.12 CRG84275.1 - 7.2e-107 357.2 9.0 8.2e-107 357.0 9.0 1.0 1 0 0 1 1 1 1 TAP42-like family Atg31 PF09795.9 CRG84275.1 - 0.029 14.4 0.8 0.1 12.6 0.1 2.0 1 1 1 2 2 2 0 Autophagy-related protein 31 Ribonuclease_3 PF00636.26 CRG84276.1 - 4.3e-39 133.4 0.0 7.1e-18 65.2 0.0 3.0 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 CRG84276.1 - 6e-23 80.8 0.4 4.2e-22 78.1 0.3 2.4 2 0 0 2 2 2 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 CRG84276.1 - 2.2e-20 73.1 0.0 7.8e-10 39.0 0.0 3.8 2 2 0 2 2 2 2 Ribonuclease-III-like Helicase_C PF00271.31 CRG84276.1 - 3.2e-17 62.9 0.1 8.9e-17 61.4 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG84276.1 - 1.8e-10 41.0 0.1 8.3e-10 38.9 0.1 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CRG84276.1 - 2.5e-09 37.1 0.1 8.8e-09 35.4 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase DHC_N1 PF08385.12 CRG84277.1 - 1.6e-126 423.2 5.4 1.6e-126 423.2 5.4 4.4 6 0 0 6 6 6 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 CRG84277.1 - 1.1e-125 419.0 0.0 6.2e-125 416.5 0.0 2.4 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 CRG84277.1 - 4.4e-116 388.3 9.4 4.4e-116 388.3 9.4 4.4 6 1 0 6 6 4 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 CRG84277.1 - 4.4e-75 251.6 1.8 4.4e-75 251.6 1.8 4.7 5 1 0 5 5 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 CRG84277.1 - 2.4e-58 197.5 0.1 4.6e-57 193.3 0.1 2.7 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 CRG84277.1 - 2.8e-41 141.0 0.0 7.6e-36 123.3 0.0 4.9 5 0 0 5 5 4 2 P-loop containing dynein motor region MT PF12777.7 CRG84277.1 - 9.6e-40 136.7 7.8 1.8e-39 135.7 7.8 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 CRG84277.1 - 1.2e-34 119.0 1.1 6e-27 94.1 0.0 5.3 5 0 0 5 5 4 2 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 CRG84277.1 - 2.9e-31 108.3 0.3 1.3e-09 38.2 0.0 6.3 5 1 0 5 5 5 4 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 CRG84277.1 - 6.1e-27 94.4 0.0 1.6e-26 93.1 0.0 1.8 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_AAA_lid PF17852.1 CRG84277.1 - 7.5e-19 68.1 0.1 1.2e-17 64.1 0.0 2.9 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 CRG84277.1 - 6.1e-15 55.7 0.0 0.01 16.1 0.0 5.8 4 0 0 4 4 4 3 AAA domain AAA PF00004.29 CRG84277.1 - 2.6e-14 53.8 0.0 0.0003 21.2 0.0 4.7 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CRG84277.1 - 2e-09 37.8 3.3 0.25 11.5 0.0 5.7 5 1 0 5 5 4 3 AAA domain AAA_16 PF13191.6 CRG84277.1 - 2.8e-09 37.6 0.9 1.2 9.5 0.0 7.0 6 0 0 6 6 5 2 AAA ATPase domain AAA_18 PF13238.6 CRG84277.1 - 3.2e-09 37.4 0.1 0.026 15.1 0.0 5.3 4 0 0 4 4 4 2 AAA domain ABC_tran PF00005.27 CRG84277.1 - 1.5e-05 25.5 0.6 1.7 9.2 0.0 5.1 4 0 0 4 4 3 1 ABC transporter T2SSE PF00437.20 CRG84277.1 - 3.2e-05 23.1 0.0 0.035 13.2 0.0 3.3 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_14 PF13173.6 CRG84277.1 - 5.2e-05 23.3 0.0 1.7 8.7 0.0 4.4 4 0 0 4 4 4 2 AAA domain AAA_lid_1 PF17857.1 CRG84277.1 - 0.00014 22.0 0.2 0.0024 18.1 0.0 3.2 3 0 0 3 3 2 1 AAA+ lid domain Mg_chelatase PF01078.21 CRG84277.1 - 0.00027 20.4 0.4 0.66 9.3 0.0 3.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CRG84277.1 - 0.00027 20.7 0.6 39 3.9 0.0 5.3 5 0 0 5 5 5 0 AAA domain AAA_29 PF13555.6 CRG84277.1 - 0.00031 20.4 0.1 2.3 8.1 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_25 PF13481.6 CRG84277.1 - 0.0011 18.5 0.0 0.26 10.8 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 CRG84277.1 - 0.0012 19.2 1.3 0.27 11.5 0.0 4.2 4 0 0 4 4 3 1 AAA domain AAA_24 PF13479.6 CRG84277.1 - 0.0019 18.0 0.0 11 5.7 0.0 4.3 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 CRG84277.1 - 0.0028 17.0 1.3 1.7 7.9 0.0 4.3 4 0 0 4 4 3 1 FtsK/SpoIIIE family IstB_IS21 PF01695.17 CRG84277.1 - 0.0066 16.2 2.1 0.86 9.3 0.0 4.5 5 0 0 5 5 4 1 IstB-like ATP binding protein Rad17 PF03215.15 CRG84277.1 - 0.018 15.0 0.4 7.1 6.5 0.0 4.1 5 0 0 5 5 4 0 Rad17 P-loop domain ERM PF00769.19 CRG84277.1 - 0.028 14.2 23.5 0.31 10.8 12.6 3.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family RNA_helicase PF00910.22 CRG84277.1 - 0.035 14.5 0.6 1.1e+02 3.2 0.0 4.9 5 0 0 5 5 4 0 RNA helicase DUF4482 PF14818.6 CRG84277.1 - 0.043 14.7 10.8 19 6.1 9.9 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Vps23_core PF09454.10 CRG84277.1 - 0.066 13.2 0.3 3.5 7.6 0.2 2.9 2 0 0 2 2 2 0 Vps23 core domain COG2 PF06148.11 CRG84277.1 - 0.13 12.4 0.0 0.13 12.4 0.0 5.8 6 0 0 6 6 4 0 COG (conserved oligomeric Golgi) complex component, COG2 cobW PF02492.19 CRG84277.1 - 1.5 8.3 3.7 52 3.4 0.0 4.2 5 0 0 5 5 4 0 CobW/HypB/UreG, nucleotide-binding domain ALMT PF11744.8 CRG84277.1 - 1.8 7.3 6.4 4.2 6.1 6.4 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Hemerythrin PF01814.23 CRG84277.1 - 2.3 8.9 8.8 1.1 9.9 0.3 4.6 5 0 0 5 5 2 0 Hemerythrin HHE cation binding domain Phage_GP20 PF06810.11 CRG84277.1 - 5.5 6.8 19.9 9.3 6.0 9.7 3.9 3 0 0 3 3 3 0 Phage minor structural protein GP20 Acetyltransf_1 PF00583.25 CRG84279.1 - 1.6e-05 25.1 0.0 3.6e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG84279.1 - 0.034 14.6 0.0 0.11 13.0 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CRG84279.1 - 0.064 13.2 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase PrkA PF06798.12 CRG84280.1 - 0.035 13.7 0.0 0.042 13.5 0.0 1.1 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain Svf1_C PF17187.4 CRG84281.1 - 1.8e-57 193.8 0.1 9.6e-57 191.4 0.0 2.0 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 CRG84281.1 - 2.9e-57 193.3 0.0 4.4e-57 192.7 0.0 1.3 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Ribosomal_L11 PF00298.19 CRG84282.1 - 2.3e-27 95.3 0.0 3.4e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 CRG84282.1 - 1.3e-25 89.0 0.1 2.3e-25 88.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain DUF3613 PF12266.8 CRG84282.1 - 0.16 11.8 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) Pkinase PF00069.25 CRG84283.1 - 1.6e-46 158.8 0.0 3.8e-43 147.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84283.1 - 1.7e-20 73.4 0.0 2.9e-20 72.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CRG84283.1 - 0.0097 15.9 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CRG84283.1 - 0.023 13.6 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 CRG84283.1 - 0.054 13.1 0.0 1.6 8.3 0.0 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CRG84283.1 - 0.22 10.8 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mito_carr PF00153.27 CRG84284.1 - 1.1e-44 150.2 2.2 5.1e-19 68.0 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Met_10 PF02475.16 CRG84285.1 - 0.00014 21.7 0.0 0.0005 19.9 0.0 1.8 1 1 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 CRG84285.1 - 0.19 11.3 0.0 0.37 10.4 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 EF-hand_6 PF13405.6 CRG84286.1 - 1.8e-07 30.5 0.0 0.0023 17.7 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 CRG84286.1 - 0.0006 20.2 0.1 0.0018 18.7 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 CRG84286.1 - 0.11 12.1 0.0 2.4 7.9 0.0 2.4 2 0 0 2 2 2 0 EF hand Sigma70_ner PF04546.13 CRG84287.1 - 0.0092 15.9 0.0 0.26 11.1 0.1 2.5 2 1 0 2 2 2 1 Sigma-70, non-essential region WASH_WAHD PF11945.8 CRG84287.1 - 0.094 12.2 1.2 0.29 10.6 0.0 2.1 2 1 0 2 2 2 0 WAHD domain of WASH complex OB_NTP_bind PF07717.16 CRG84288.1 - 6.3e-22 77.7 0.1 5.1e-21 74.8 0.1 2.4 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CRG84288.1 - 4.6e-19 68.7 0.0 1e-18 67.6 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CRG84288.1 - 1.3e-10 41.6 0.0 4.9e-10 39.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG84288.1 - 2.6e-08 33.8 0.3 4.4e-08 33.1 0.3 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CRG84288.1 - 1e-05 25.8 0.1 3.7e-05 24.0 0.1 1.9 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 CRG84288.1 - 0.00022 20.9 0.4 0.00064 19.4 0.4 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 CRG84288.1 - 0.00049 20.4 0.2 0.00092 19.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 CRG84288.1 - 0.00092 19.2 0.2 0.0018 18.3 0.2 1.4 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 CRG84288.1 - 0.0071 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CRG84288.1 - 0.0078 15.3 0.0 0.037 13.1 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_7 PF12775.7 CRG84288.1 - 0.044 13.3 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 CRG84288.1 - 0.057 13.9 0.0 0.097 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRMT5_TIM PF17285.2 CRG84289.1 - 2.1e-74 250.0 0.0 3e-74 249.5 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 CRG84289.1 - 1.8e-66 223.2 0.0 3.8e-66 222.2 0.0 1.6 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 CRG84289.1 - 5.1e-58 195.8 0.0 1.5e-57 194.3 0.0 1.9 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_28 PF02636.17 CRG84289.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase GDPD PF03009.17 CRG84290.1 - 8.8e-74 248.5 0.0 2e-73 247.3 0.0 1.7 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 CRG84290.1 - 2.4e-26 92.1 0.0 9.5e-16 58.2 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) SPX PF03105.19 CRG84290.1 - 2.9e-21 76.8 17.0 2.4e-11 44.2 0.1 4.3 2 2 2 4 4 4 3 SPX domain Ank_4 PF13637.6 CRG84290.1 - 4.9e-20 71.6 1.0 1.2e-06 28.9 0.1 4.7 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG84290.1 - 4.8e-17 60.3 0.3 0.0051 17.2 0.0 7.0 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 CRG84290.1 - 1.9e-14 53.5 0.4 1.7e-05 25.0 0.1 5.4 3 1 3 6 6 6 3 Ankyrin repeats (many copies) Ank PF00023.30 CRG84290.1 - 2.1e-12 46.9 2.9 0.018 15.4 0.0 6.7 6 1 0 6 6 6 3 Ankyrin repeat Dynamitin PF04912.14 CRG84290.1 - 0.078 12.3 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Dynamitin Caps_synth_GfcC PF06251.11 CRG84290.1 - 0.17 11.5 0.3 0.98 9.0 0.1 2.1 2 0 0 2 2 2 0 Capsule biosynthesis GfcC CRR7 PF12095.8 CRG84290.1 - 0.18 12.3 0.6 16 6.0 0.0 3.5 3 0 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 UNC45-central PF11701.8 CRG84291.1 - 5.5e-47 159.5 1.5 3.1e-46 157.1 0.2 2.9 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central TPR_15 PF13429.6 CRG84291.1 - 0.036 13.3 0.1 0.036 13.3 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Arm PF00514.23 CRG84291.1 - 0.036 14.1 16.5 1.6 8.8 0.0 6.8 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat TPR_2 PF07719.17 CRG84291.1 - 0.22 11.7 1.5 0.51 10.6 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Tfb4 PF03850.14 CRG84292.1 - 4e-120 400.4 1.0 4.8e-120 400.2 1.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Asparaginase_2 PF01112.18 CRG84294.1 - 9.7e-46 156.2 1.3 9.1e-45 153.0 1.3 2.0 1 1 0 1 1 1 1 Asparaginase Actin PF00022.19 CRG84295.1 - 7.7e-88 294.8 0.0 1.5e-85 287.2 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CRG84295.1 - 0.036 12.9 0.0 0.86 8.4 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein tRNA_U5-meth_tr PF05958.11 CRG84296.1 - 6.7e-13 48.4 0.1 1.2e-05 24.5 0.0 2.5 3 0 0 3 3 3 2 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 CRG84296.1 - 0.00032 20.3 0.1 0.00061 19.4 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 CRG84296.1 - 0.0028 17.5 0.0 0.0059 16.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84296.1 - 0.0044 17.7 0.0 0.011 16.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CRG84296.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) SidC_N PF18219.1 CRG84296.1 - 0.072 12.1 0.1 1.4 7.8 0.0 2.1 2 0 0 2 2 2 0 SidC N-terminal domain Methyltransf_11 PF08241.12 CRG84296.1 - 0.14 12.8 0.0 0.35 11.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CRG84296.1 - 0.19 11.3 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain BNIP3 PF06553.12 CRG84296.1 - 0.22 11.2 2.5 0.87 9.2 2.4 1.8 1 1 1 2 2 2 0 BNIP3 Ribosomal_S5_C PF03719.15 CRG84297.1 - 2.5e-24 84.5 0.0 4.6e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 CRG84297.1 - 6.3e-18 64.5 0.7 1.2e-17 63.7 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain DASH_Dad3 PF08656.10 CRG84298.1 - 3.2e-27 94.4 0.9 4.9e-27 93.8 0.9 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad3 Pkinase PF00069.25 CRG84299.1 - 4.3e-74 249.2 0.0 5.8e-74 248.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84299.1 - 4e-30 105.0 0.0 6.7e-22 78.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CRG84299.1 - 1.3e-06 27.9 0.0 0.69 9.2 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 CRG84299.1 - 0.026 13.3 0.0 0.052 12.3 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 CRG84299.1 - 0.042 13.2 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG84299.1 - 0.13 12.2 0.0 2.8 7.8 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1631 PF07793.11 CRG84300.1 - 2.3 6.5 6.6 5.5 5.3 6.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) His_Phos_2 PF00328.22 CRG84301.1 - 1.8e-08 34.2 0.0 5.1e-08 32.7 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) TRF PF08558.10 CRG84302.1 - 1.4e-88 296.5 5.9 2.3e-88 295.8 5.9 1.3 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 CRG84302.1 - 0.00045 20.4 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain CPSF100_C PF13299.6 CRG84302.1 - 7.5 6.7 8.2 33 4.6 4.7 2.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Hexokinase_2 PF03727.16 CRG84303.1 - 1.5e-62 211.2 0.0 3.4e-46 157.6 0.0 2.1 1 1 1 2 2 2 2 Hexokinase Hexokinase_1 PF00349.21 CRG84303.1 - 1.1e-29 103.8 0.0 1.8e-29 103.1 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Lambda_CIII PF02061.16 CRG84303.1 - 0.041 13.9 0.1 0.084 12.9 0.1 1.5 1 0 0 1 1 1 0 Lambda Phage CIII Zn_clus PF00172.18 CRG84304.1 - 7.3e-07 29.2 8.9 7.3e-07 29.2 8.9 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glucosamine_iso PF01182.20 CRG84305.1 - 1.8e-20 73.8 0.0 2.7e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase AA_permease_2 PF13520.6 CRG84307.1 - 3.3e-55 187.7 55.7 3.9e-55 187.4 55.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG84307.1 - 1.4e-21 76.7 43.2 1.8e-21 76.3 43.2 1.0 1 0 0 1 1 1 1 Amino acid permease TFIID_30kDa PF03540.13 CRG84310.1 - 1.1e-22 79.7 0.1 1.6e-22 79.2 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit FoP_duplication PF13865.6 CRG84310.1 - 0.079 13.5 4.9 0.25 11.9 4.8 2.0 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 IPK PF03770.16 CRG84311.1 - 5.9e-61 205.8 0.0 8.6e-61 205.2 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase Arb1 PF09692.10 CRG84312.1 - 2.9e-116 389.0 0.0 3.7e-116 388.6 0.0 1.1 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 ADH_zinc_N PF00107.26 CRG84313.1 - 3.3e-26 91.8 0.0 6.1e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG84313.1 - 5.5e-22 79.2 0.0 9.6e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG84313.1 - 1.6e-08 34.4 0.0 6.2e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain PyrI PF01948.18 CRG84313.1 - 0.1 12.8 0.3 0.35 11.1 0.1 2.0 2 1 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain CLP1_N PF16573.5 CRG84316.1 - 6.5e-33 112.8 0.0 2e-32 111.2 0.0 1.9 1 1 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor CLP1_P PF16575.5 CRG84316.1 - 1.6e-27 96.5 0.0 1.4e-26 93.5 0.0 2.4 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 CRG84316.1 - 2.8e-25 89.0 0.1 5.2e-24 84.9 0.1 2.5 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 ATP_bind_1 PF03029.17 CRG84316.1 - 0.01 15.6 0.1 0.028 14.2 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 CRG84316.1 - 0.02 14.9 0.0 0.16 12.1 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_35 PF14516.6 CRG84316.1 - 0.06 12.2 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain KilA-N PF04383.13 CRG84317.1 - 0.0011 18.8 0.2 0.016 15.0 0.0 2.7 2 1 0 2 2 2 1 KilA-N domain Hamartin PF04388.12 CRG84317.1 - 5.3 5.6 25.2 7 5.2 25.2 1.1 1 0 0 1 1 1 0 Hamartin protein Rho_GDI PF02115.17 CRG84318.1 - 1.3e-63 214.3 0.2 1.5e-63 214.1 0.2 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.28 CRG84319.1 - 6.7e-37 128.0 0.7 8.6e-37 127.6 0.7 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CRG84319.1 - 0.012 16.1 0.4 0.036 14.5 0.4 1.8 1 1 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 CRG84319.1 - 0.12 12.5 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Adaptin_N PF01602.20 CRG84322.1 - 7.8e-106 354.7 0.0 9.3e-106 354.4 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CRG84322.1 - 4.5e-17 62.6 0.2 3.4e-12 46.7 0.0 3.8 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CRG84322.1 - 6.7e-10 39.2 0.7 0.00042 20.6 0.0 3.8 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 CRG84322.1 - 8.1e-07 28.8 0.1 0.11 12.8 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Arm PF00514.23 CRG84322.1 - 0.00089 19.2 0.6 1.1 9.4 0.1 4.3 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat MOR2-PAG1_N PF14222.6 CRG84322.1 - 0.0039 16.2 0.1 0.0066 15.5 0.1 1.3 1 0 0 1 1 1 1 Cell morphogenesis N-terminal VHS PF00790.19 CRG84322.1 - 0.0043 16.9 0.7 10 6.0 0.0 3.4 3 0 0 3 3 3 1 VHS domain CRISPR_Cse2 PF09485.10 CRG84322.1 - 0.0092 16.5 0.4 18 5.8 0.1 3.8 3 0 0 3 3 3 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Cnd3 PF12719.7 CRG84322.1 - 0.012 14.8 0.0 0.057 12.6 0.0 2.0 2 0 0 2 2 2 0 Nuclear condensing complex subunits, C-term domain SPO22 PF08631.10 CRG84322.1 - 0.055 13.0 0.1 16 4.8 0.0 2.9 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like Cohesin_HEAT PF12765.7 CRG84322.1 - 0.14 12.5 6.3 1.2 9.5 0.0 4.2 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion CNDH2_C PF16858.5 CRG84322.1 - 6.7 6.5 15.8 0.17 11.8 8.9 1.8 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term AIRS PF00586.24 CRG84323.1 - 0.027 15.1 0.0 1.4 9.6 0.0 2.2 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain Nuf2 PF03800.14 CRG84324.1 - 6.4e-42 143.0 0.1 6.4e-42 143.0 0.1 2.1 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 CRG84324.1 - 3.3e-35 120.6 20.3 3.3e-35 120.6 20.3 4.0 2 2 1 3 3 3 1 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 CRG84324.1 - 0.61 10.5 0.1 0.61 10.5 0.1 5.4 3 3 2 5 5 5 0 Flagella accessory protein C (FlaC) DASH_Dam1 PF08653.10 CRG84324.1 - 0.98 9.3 7.1 3.4 7.5 0.1 4.2 4 2 0 4 4 4 0 DASH complex subunit Dam1 IF-2B PF01008.17 CRG84325.1 - 5.3e-48 163.6 0.0 1e-47 162.7 0.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family DeoRC PF00455.22 CRG84325.1 - 0.12 12.3 0.0 24 4.8 0.0 2.6 2 1 0 2 2 2 0 DeoR C terminal sensor domain DUF1681 PF07933.14 CRG84327.1 - 5.6e-58 194.9 0.0 7.5e-58 194.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) KCNQ2_u3 PF16642.5 CRG84327.1 - 0.029 15.4 2.0 0.054 14.5 2.0 1.4 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Eisosome1 PF12757.7 CRG84328.1 - 0.0056 16.9 2.5 0.0056 16.9 2.5 2.1 2 0 0 2 2 2 1 Eisosome protein 1 Thioredoxin PF00085.20 CRG84329.1 - 4e-31 107.1 0.1 4.8e-31 106.8 0.1 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 CRG84329.1 - 6.5e-08 33.0 0.0 1e-07 32.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CRG84329.1 - 9.9e-08 32.2 0.0 2.1e-07 31.2 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 CRG84329.1 - 1.9e-05 24.2 0.0 2.2e-05 24.0 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Redoxin PF08534.10 CRG84329.1 - 0.00021 21.0 0.1 0.0012 18.6 0.1 1.8 1 1 0 1 1 1 1 Redoxin Thioredoxin_9 PF14595.6 CRG84329.1 - 0.00029 20.6 0.0 0.00031 20.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CRG84329.1 - 0.00034 20.5 0.0 0.00041 20.2 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 CRG84329.1 - 0.0027 17.8 0.0 0.0045 17.1 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 CRG84329.1 - 0.0032 17.4 0.1 0.0044 16.9 0.1 1.3 1 1 0 1 1 1 1 AhpC/TSA family HyaE PF07449.11 CRG84329.1 - 0.0045 16.9 0.1 0.0054 16.7 0.1 1.3 1 1 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_6 PF13848.6 CRG84329.1 - 0.0054 16.7 0.0 0.0069 16.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain Glutaredoxin PF00462.24 CRG84329.1 - 0.0083 16.3 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_5 PF13743.6 CRG84329.1 - 0.02 14.6 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin DUF953 PF06110.11 CRG84329.1 - 0.053 13.1 0.1 0.15 11.7 0.1 1.9 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) MFS_1 PF07690.16 CRG84330.1 - 5e-45 153.9 48.3 5e-45 153.9 48.3 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG84330.1 - 2.8e-15 55.8 11.5 2.8e-15 55.8 11.5 2.3 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG84330.1 - 2.4e-11 43.2 10.2 2.4e-11 43.2 10.2 3.0 2 1 1 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 CRG84330.1 - 0.83 7.9 22.5 0.11 10.7 7.5 3.1 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Acetyltransf_7 PF13508.7 CRG84331.1 - 6.2e-08 32.9 0.0 8.4e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG84331.1 - 1.1e-05 25.3 0.0 1.6e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG84331.1 - 1.5e-05 25.2 0.0 1.9e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 CRG84331.1 - 0.02 14.8 0.0 0.054 13.5 0.0 1.6 1 1 0 1 1 1 0 FR47-like protein HNH_2 PF13391.6 CRG84332.1 - 1.6e-14 53.7 0.0 3.4e-14 52.7 0.0 1.5 1 0 0 1 1 1 1 HNH endonuclease p450 PF00067.22 CRG84333.1 - 4e-64 217.1 0.0 4.5e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HAD_2 PF13419.6 CRG84334.1 - 1.4e-07 31.8 0.0 1.9e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG84334.1 - 5.4e-05 23.6 0.0 6.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG84334.1 - 0.023 14.8 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like Prenyltrans PF00432.21 CRG84335.1 - 0.12 12.2 0.4 0.33 10.7 0.4 1.9 1 1 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat BNR_2 PF13088.6 CRG84336.1 - 7.3e-18 64.8 2.1 2e-07 30.6 0.1 3.1 1 1 2 3 3 3 3 BNR repeat-like domain Sortilin-Vps10 PF15902.5 CRG84336.1 - 6e-10 38.5 5.2 2.6e-07 29.8 0.7 2.3 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, BNR_4 PF15892.5 CRG84336.1 - 1.2e-09 37.9 2.0 3.9e-06 26.4 1.2 2.6 1 1 1 2 2 2 2 BNR repeat-containing family member BNR_3 PF13859.6 CRG84336.1 - 3.4e-07 29.9 1.2 0.00038 19.9 0.1 2.3 2 0 0 2 2 2 2 BNR repeat-like domain BNR PF02012.20 CRG84336.1 - 1e-06 27.8 29.2 0.04 13.9 0.7 5.9 5 0 0 5 5 5 3 BNR/Asp-box repeat Glyco_hydro_32N PF00251.20 CRG84336.1 - 0.0046 16.6 0.2 0.61 9.6 0.5 2.7 1 1 1 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain DUF4185 PF13810.6 CRG84336.1 - 0.11 11.7 14.6 2 7.5 0.7 4.7 1 1 2 4 4 4 0 Domain of unknown function (DUF4185) CyRPA PF18638.1 CRG84336.1 - 0.56 9.3 4.9 19 4.3 0.0 4.1 4 1 1 5 5 5 0 Cysteine-Rich Protective Antigen 6 bladed domain CHB_HEX_C PF03174.13 CRG84336.1 - 2.2 8.3 7.5 64 3.6 0.1 4.5 5 0 0 5 5 5 0 Chitobiase/beta-hexosaminidase C-terminal domain DUF1214 PF06742.11 CRG84337.1 - 1.6e-07 31.8 0.1 2.7e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1214) OTU PF02338.19 CRG84339.1 - 1.3e-09 38.6 0.0 5.2e-09 36.7 0.0 1.9 1 1 0 1 1 1 1 OTU-like cysteine protease Tti2 PF10521.9 CRG84339.1 - 0.058 12.9 1.5 0.11 12.0 1.5 1.4 1 0 0 1 1 1 0 Tti2 family CUE PF02845.16 CRG84339.1 - 0.065 13.0 0.2 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 CUE domain PGA_cap PF09587.10 CRG84340.1 - 2.1e-56 191.3 0.1 4.5e-56 190.1 0.1 1.6 1 1 0 1 1 1 1 Bacterial capsule synthesis protein PGA_cap GATA PF00320.27 CRG84341.1 - 3e-28 97.1 17.8 1.8e-14 53.1 5.9 2.6 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 CRG84341.1 - 2.7e-06 26.8 2.9 0.0014 18.1 0.1 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 CRG84341.1 - 6.1e-05 23.0 2.2 0.073 13.2 0.2 2.8 2 0 0 2 2 2 2 Zinc ribbon domain OrfB_Zn_ribbon PF07282.11 CRG84341.1 - 0.00028 20.7 3.2 0.05 13.5 0.4 2.6 2 0 0 2 2 2 2 Putative transposase DNA-binding domain Auto_anti-p27 PF06677.12 CRG84341.1 - 0.0006 19.9 4.8 0.024 14.8 0.3 2.7 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) eIF-5_eIF-2B PF01873.17 CRG84341.1 - 0.0071 16.2 3.3 1.8 8.4 0.4 2.3 2 0 0 2 2 2 2 Domain found in IF2B/IF5 DZR PF12773.7 CRG84341.1 - 0.032 14.2 11.1 2.5 8.2 0.7 3.1 1 1 1 2 2 2 0 Double zinc ribbon TDP43_N PF18694.1 CRG84341.1 - 0.051 13.4 0.1 2.9 7.8 0.0 2.5 2 0 0 2 2 2 0 Transactive response DNA-binding protein N-terminal domain ArfGap PF01412.18 CRG84341.1 - 0.055 13.5 4.3 0.31 11.1 0.2 2.3 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Fungal_trans_2 PF11951.8 CRG84342.1 - 2.9e-41 141.6 0.0 3.8e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84342.1 - 3.1e-07 30.4 6.4 6.7e-07 29.3 6.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 CRG84344.1 - 8.6e-08 31.9 0.1 5.5e-06 26.0 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG84344.1 - 9.2e-08 31.9 0.0 1.1e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 2-Hacid_dh_C PF02826.19 CRG84344.1 - 0.0071 15.7 0.0 0.013 14.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CRG84344.1 - 0.013 14.6 0.1 0.022 13.9 0.0 1.4 2 0 0 2 2 2 0 RmlD substrate binding domain Epimerase PF01370.21 CRG84344.1 - 0.047 13.1 0.0 0.11 12.0 0.0 1.5 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CRG84344.1 - 0.092 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain LigB PF02900.18 CRG84345.1 - 2.9e-32 111.8 0.0 3.7e-32 111.5 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase PGA_cap PF09587.10 CRG84345.1 - 0.03 13.8 0.1 3.5 7.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap COPI_assoc PF08507.10 CRG84346.1 - 1.8e-31 108.9 8.3 1.9e-31 108.8 8.3 1.0 1 0 0 1 1 1 1 COPI associated protein adh_short PF00106.25 CRG84347.1 - 1.6e-54 184.3 0.2 2.1e-54 184.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG84347.1 - 3e-35 121.9 0.1 3.9e-35 121.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG84347.1 - 3.4e-12 46.7 0.0 4.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG84347.1 - 0.0003 20.0 0.1 0.00062 19.0 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CRG84347.1 - 0.0044 17.3 0.1 0.0082 16.4 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG84347.1 - 0.0069 15.9 0.1 0.022 14.2 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Ras PF00071.22 CRG84349.1 - 1.8e-59 199.9 0.2 2.2e-59 199.7 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG84349.1 - 1.3e-20 73.8 0.0 2e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG84349.1 - 1.1e-08 34.7 0.0 1.2e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG84349.1 - 1.7e-06 27.7 0.1 1e-05 25.1 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CRG84349.1 - 7.4e-05 22.7 0.6 0.26 11.2 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CRG84349.1 - 0.002 18.2 0.0 0.0029 17.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 CRG84349.1 - 0.0032 17.4 0.0 0.0066 16.4 0.0 1.6 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 CRG84349.1 - 0.021 14.3 0.0 0.038 13.5 0.0 1.4 1 1 0 1 1 1 0 Ferrous iron transport protein B Ser_hydrolase PF06821.13 CRG84349.1 - 0.048 13.5 0.0 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase DUF2075 PF09848.9 CRG84349.1 - 0.12 11.6 0.7 10 5.2 0.0 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 CRG84349.1 - 0.19 11.5 0.9 2.6 7.7 0.2 2.2 1 1 1 2 2 2 0 IstB-like ATP binding protein MoCF_biosynth PF00994.24 CRG84350.1 - 4.2e-32 110.8 0.0 7e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain FAD_syn PF06574.12 CRG84350.1 - 0.18 11.7 0.0 0.46 10.4 0.0 1.6 2 0 0 2 2 2 0 FAD synthetase Cofilin_ADF PF00241.20 CRG84351.1 - 3.3e-18 65.6 0.0 4e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DZR PF12773.7 CRG84352.1 - 0.017 15.2 2.2 0.017 15.2 2.2 3.7 2 2 1 3 3 3 0 Double zinc ribbon zinc_ribbon_9 PF14369.6 CRG84352.1 - 0.49 10.7 10.7 0.21 11.9 1.5 3.2 2 1 0 2 2 2 0 zinc-ribbon IBR PF01485.21 CRG84352.1 - 2.6 8.3 18.6 0.93 9.8 4.6 3.3 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain FYVE_2 PF02318.16 CRG84352.1 - 3.2 8.0 14.0 1.3 9.3 3.4 3.1 3 0 0 3 3 3 0 FYVE-type zinc finger zf-C3HC4_3 PF13920.6 CRG84352.1 - 8.8 6.3 24.1 4.5 7.2 1.4 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 CRG84353.1 - 2.1e-54 184.6 0.0 3.1e-54 184.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG84353.1 - 5.7e-11 42.8 0.0 6.9e-10 39.3 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG84353.1 - 5.1e-10 39.6 0.0 1.1e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CRG84353.1 - 8.6e-10 38.6 0.0 1.8e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CRG84353.1 - 2.6e-07 30.6 0.0 5.2e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF3861 PF12977.7 CRG84353.1 - 0.0048 17.0 0.2 1.3 9.2 0.0 2.9 2 0 0 2 2 2 1 Domain of Unknown Function with PDB structure (DUF3861) AAA_22 PF13401.6 CRG84353.1 - 0.048 13.9 0.0 0.21 11.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain UPF0086 PF01868.16 CRG84355.1 - 2.3e-31 107.6 0.1 7.6e-31 105.9 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function UPF0086 tRNA_int_endo PF01974.17 CRG84356.1 - 2.4e-15 56.3 0.0 5.1e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PAXNEB PF05625.11 CRG84357.1 - 2.4e-106 356.0 0.0 9.5e-73 245.5 0.0 2.0 1 1 1 2 2 2 2 PAXNEB protein DUF1773 PF08593.10 CRG84357.1 - 0.039 15.0 0.0 0.16 13.0 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function RNA_pol_Rpb8 PF03870.15 CRG84358.1 - 2.7e-45 154.0 0.0 3e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 CRG84358.1 - 4.5e-05 23.5 0.0 0.17 11.9 0.1 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G NUDIX PF00293.28 CRG84360.1 - 3.2e-13 49.9 0.0 5.9e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 CRG84360.1 - 1.7e-12 47.4 0.0 2.4e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) DUF775 PF05603.12 CRG84361.1 - 1.4e-68 230.4 0.1 1.6e-68 230.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) GATase PF00117.28 CRG84362.1 - 3.3e-13 49.8 0.0 4.4e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 CRG84362.1 - 0.00078 19.1 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 CRG84362.1 - 0.014 15.1 0.1 4.4 7.0 0.2 2.8 2 1 0 2 2 2 0 Peptidase C26 RecX PF02631.16 CRG84362.1 - 0.064 13.7 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 RecX family MFS_1 PF07690.16 CRG84363.1 - 4.8e-41 140.8 39.4 4.8e-41 140.8 39.4 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG84363.1 - 1e-09 37.4 15.8 1.2e-09 37.2 14.8 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG84363.1 - 4.3e-09 35.8 26.3 1.1e-08 34.4 16.5 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 CRG84363.1 - 0.7 8.2 14.0 0.024 13.0 4.1 2.6 2 1 0 2 2 2 0 Transmembrane secretion effector YwcE PF17368.2 CRG84364.1 - 7.2 7.4 7.5 2.3 8.9 0.1 3.0 3 1 0 3 3 3 0 Spore morphogenesis and germination YwcE Tannase PF07519.11 CRG84365.1 - 5.7e-111 371.7 0.1 6.9e-111 371.4 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 CRG84365.1 - 0.0024 17.5 0.0 0.0055 16.4 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG84365.1 - 0.021 14.1 0.0 0.043 13.1 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CRG84365.1 - 0.098 12.1 0.1 9.6 5.6 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family SIR2 PF02146.17 CRG84367.1 - 1.3e-47 162.0 0.0 1.7e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CRG84367.1 - 0.00011 22.0 0.0 0.0039 16.9 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain FAD_binding_3 PF01494.19 CRG84368.1 - 8.1e-37 127.3 0.0 6.4e-36 124.3 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain ThiF PF00899.21 CRG84368.1 - 0.067 12.5 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 ThiF family zf-H2C2_2 PF13465.6 CRG84369.1 - 4.1e-06 27.0 5.2 4.1e-06 27.0 5.2 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG84369.1 - 0.004 17.9 22.3 0.012 16.4 2.5 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger DIT1_PvcA PF05141.12 CRG84369.1 - 0.015 14.8 0.1 0.031 13.7 0.1 1.5 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein zf-C2H2 PF00096.26 CRG84369.1 - 0.016 15.7 5.6 0.016 15.7 5.6 3.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type DZR PF12773.7 CRG84369.1 - 0.06 13.4 1.9 0.073 13.1 0.8 1.7 2 0 0 2 2 2 0 Double zinc ribbon BIR PF00653.21 CRG84369.1 - 0.75 10.5 4.9 2.3 8.9 2.4 2.8 3 0 0 3 3 3 0 Inhibitor of Apoptosis domain zf-met PF12874.7 CRG84369.1 - 6.3 7.3 7.1 13 6.3 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Fungal_trans_2 PF11951.8 CRG84370.1 - 3e-08 32.9 2.8 1.5e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84370.1 - 8e-06 25.9 9.8 8e-06 25.9 9.8 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WD40 PF00400.32 CRG84371.1 - 5.4e-13 49.2 1.7 0.0023 18.7 0.1 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG84371.1 - 0.019 15.3 0.6 6.6 7.1 0.1 4.1 5 1 0 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain DEAD PF00270.29 CRG84372.1 - 8.4e-42 142.9 0.1 1.2e-41 142.4 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG84372.1 - 5.3e-20 71.8 0.0 5.5e-19 68.6 0.0 2.4 1 1 1 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CRG84372.1 - 1.2e-17 63.8 0.2 3.2e-17 62.5 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CRG84372.1 - 1.9e-05 24.7 0.1 9.1e-05 22.5 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG84372.1 - 0.0023 17.2 0.0 0.0048 16.1 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF1045 PF06299.12 CRG84372.1 - 0.07 13.1 0.3 0.18 11.7 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) Pyridox_oxase_2 PF12766.7 CRG84375.1 - 1.4e-26 93.0 0.0 2.4e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 CRG84375.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase SKG6 PF08693.10 CRG84377.1 - 0.00012 21.4 0.2 0.00023 20.5 0.2 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Rax2 PF12768.7 CRG84377.1 - 0.0012 18.4 0.1 0.0055 16.2 0.1 1.8 1 1 1 2 2 2 1 Cortical protein marker for cell polarity Podoplanin PF05808.11 CRG84377.1 - 0.0032 17.6 0.1 0.0049 17.0 0.1 1.4 1 0 0 1 1 1 1 Podoplanin Gram_pos_anchor PF00746.21 CRG84377.1 - 0.024 14.6 0.1 0.024 14.6 0.1 1.9 2 1 0 2 2 2 0 LPXTG cell wall anchor motif GDA1_CD39 PF01150.17 CRG84378.1 - 4.2e-105 351.9 0.0 5.8e-105 351.4 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family LRR_9 PF14580.6 CRG84378.1 - 7.6e-41 139.5 0.2 1.3e-40 138.7 0.2 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_8 PF13855.6 CRG84378.1 - 4.1e-05 23.3 0.3 8.4e-05 22.3 0.3 1.5 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 CRG84378.1 - 0.00094 19.5 2.3 0.01 16.3 0.9 2.5 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) HTH_38 PF13936.6 CRG84378.1 - 0.048 13.4 1.7 0.062 13.1 0.4 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain DUF4349 PF14257.6 CRG84378.1 - 0.098 12.1 0.8 0.18 11.3 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Ammonium_transp PF00909.21 CRG84379.1 - 5.6e-111 371.1 25.2 6.6e-111 370.8 25.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Acyltransferase PF01553.21 CRG84380.1 - 1.4e-16 60.4 0.0 2.9e-16 59.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase DUF1117 PF06547.12 CRG84380.1 - 0.75 10.4 3.0 9.3 6.8 1.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) Pantoate_ligase PF02569.15 CRG84381.1 - 2.9e-94 315.2 0.0 3.4e-94 315.0 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase ATP-sulfurylase PF01747.17 CRG84381.1 - 0.12 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 ATP-sulfurylase RSN1_7TM PF02714.15 CRG84384.1 - 1.5e-90 303.2 25.3 3e-90 302.3 16.3 3.0 3 0 0 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CRG84384.1 - 1.8e-44 151.2 6.6 1.8e-44 151.2 6.6 2.4 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CRG84384.1 - 2.7e-41 141.7 0.1 4.3e-41 141.1 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 CRG84384.1 - 1.8e-32 111.4 0.6 4.8e-32 110.0 0.6 1.8 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter DUF5533 PF17685.1 CRG84385.1 - 0.15 12.5 0.0 0.3 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5533) MCM PF00493.23 CRG84386.1 - 4.9e-101 336.5 0.1 9.1e-101 335.6 0.1 1.5 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CRG84386.1 - 4.5e-39 133.2 0.3 9.5e-39 132.1 0.3 1.5 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 CRG84386.1 - 7.5e-35 119.4 0.7 2.9e-34 117.5 0.7 2.1 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 CRG84386.1 - 2.6e-24 85.5 0.6 7e-24 84.1 0.6 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CRG84386.1 - 1.6e-22 80.0 2.1 2.9e-22 79.2 0.7 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 CRG84386.1 - 5e-06 26.1 0.0 3.5e-05 23.3 0.0 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CRG84386.1 - 0.0026 17.7 0.0 0.008 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CRG84386.1 - 0.0029 17.5 0.0 0.013 15.4 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CRG84386.1 - 0.011 15.4 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Lyase_aromatic PF00221.19 CRG84387.1 - 8e-155 516.0 9.9 1e-154 515.7 9.9 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase She9_MDM33 PF05546.11 CRG84388.1 - 1.1e-89 299.5 8.2 1.4e-89 299.1 8.2 1.1 1 0 0 1 1 1 1 She9 / Mdm33 family PsbH PF00737.20 CRG84388.1 - 0.039 13.7 1.1 0.085 12.6 1.1 1.5 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein FliJ PF02050.16 CRG84388.1 - 0.21 11.8 9.6 0.51 10.6 2.8 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein Pmp3 PF01679.17 CRG84389.1 - 1.1e-18 67.2 9.7 1.4e-18 66.9 9.7 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator SH3_9 PF14604.6 CRG84390.1 - 2.5e-05 24.1 0.2 5.5e-05 22.9 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG84390.1 - 0.00014 21.4 0.2 0.0003 20.3 0.2 1.5 1 0 0 1 1 1 1 SH3 domain Mid2 PF04478.12 CRG84390.1 - 0.0038 17.1 0.0 0.009 15.9 0.0 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 CRG84390.1 - 0.02 14.6 0.4 0.037 13.8 0.4 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEM154 PF15102.6 CRG84390.1 - 0.078 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 CRG84390.1 - 0.1 13.5 0.0 0.2 12.5 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4690 PF15756.5 CRG84390.1 - 0.12 13.0 0.2 0.4 11.3 0.2 1.9 1 0 0 1 1 1 0 Small Novel Rich in Cartilage UPF0240 PF06784.11 CRG84390.1 - 0.24 11.4 0.0 0.48 10.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) VPDSG-CTERM PF18205.1 CRG84390.1 - 6 6.8 5.7 15 5.5 5.7 1.7 1 0 0 1 1 1 0 VPDSG-CTERM motif Nup192 PF11894.8 CRG84391.1 - 0 1362.8 21.3 0 1362.4 21.3 1.1 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Cullin PF00888.22 CRG84391.1 - 2.7e-176 587.8 7.9 2.7e-176 587.8 7.9 2.0 2 0 0 2 2 2 1 Cullin family SNF2_N PF00176.23 CRG84391.1 - 1.1e-44 152.7 0.0 2.6e-44 151.4 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Cullin_Nedd8 PF10557.9 CRG84391.1 - 1.6e-23 82.5 1.2 4.7e-23 81.0 1.2 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain Helicase_C PF00271.31 CRG84391.1 - 1.5e-09 38.1 0.0 5.3e-09 36.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 CRG84391.1 - 0.002 18.0 9.1 0.0041 16.9 9.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG84391.1 - 0.0033 17.2 8.9 0.007 16.2 8.9 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CRG84391.1 - 0.0059 16.6 2.2 0.017 15.1 2.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CRG84391.1 - 0.0082 16.0 4.5 0.023 14.5 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG84391.1 - 1.4 9.0 5.6 3.4 7.7 5.6 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 CRG84391.1 - 7.3 7.0 5.9 19 5.7 5.9 1.8 1 0 0 1 1 1 0 Ring finger domain GATA PF00320.27 CRG84392.1 - 4.6e-05 22.9 4.6 0.01 15.4 1.4 2.6 2 0 0 2 2 2 2 GATA zinc finger LSM PF01423.22 CRG84394.1 - 8.8e-13 47.8 0.1 1.2e-12 47.3 0.1 1.2 1 0 0 1 1 1 1 LSM domain Dak1 PF02733.17 CRG84395.1 - 1.9e-103 345.6 0.1 2.7e-103 345.1 0.1 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 CRG84395.1 - 1.3e-47 161.9 1.8 2.1e-47 161.3 1.8 1.3 1 0 0 1 1 1 1 DAK2 domain MFS_1 PF07690.16 CRG84396.1 - 6.5e-25 87.8 31.6 8.6e-25 87.4 31.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG84396.1 - 3.2e-05 23.4 17.0 0.011 15.1 3.9 2.5 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB FAD_binding_3 PF01494.19 CRG84397.1 - 1e-10 41.4 1.1 3.3e-10 39.7 1.1 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG84397.1 - 0.00057 20.1 0.1 0.0016 18.6 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG84397.1 - 0.018 15.0 0.2 0.05 13.6 0.2 1.7 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CRG84397.1 - 0.033 13.4 0.6 3.4 6.8 0.2 2.2 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG84397.1 - 0.034 13.0 0.1 0.14 11.0 0.0 1.9 1 1 1 2 2 2 0 Tryptophan halogenase DAO PF01266.24 CRG84397.1 - 0.32 10.5 4.2 0.11 12.1 0.5 2.0 3 1 0 3 3 3 0 FAD dependent oxidoreductase MFAP1 PF06991.11 CRG84398.1 - 6.6e-66 222.3 33.5 6.6e-66 222.3 33.5 3.9 2 1 2 4 4 4 1 Microfibril-associated/Pre-mRNA processing Y2_Tnp PF04986.13 CRG84398.1 - 9.3 6.3 6.3 98 2.9 6.3 2.2 1 1 0 1 1 1 0 Putative transposase TRAPP PF04051.16 CRG84399.1 - 3.9e-41 140.2 0.0 5.1e-41 139.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component NAD_kinase PF01513.21 CRG84400.1 - 1.2e-73 247.9 0.0 1.8e-73 247.3 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Las1 PF04031.13 CRG84402.1 - 2.5e-48 164.1 1.0 6.3e-48 162.8 0.0 2.0 2 0 0 2 2 2 1 Las1-like HAGH_C PF16123.5 CRG84402.1 - 7.3e-18 64.9 0.1 2.4e-17 63.2 0.1 1.9 2 0 0 2 2 2 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 CRG84402.1 - 6e-16 59.0 1.5 5.6e-09 36.3 0.2 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG84402.1 - 0.0078 15.7 1.3 0.11 12.0 1.3 2.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF1264 PF06884.11 CRG84403.1 - 9.6e-77 256.4 0.0 1.1e-76 256.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) Peptidase_S26 PF10502.9 CRG84404.1 - 4.6e-06 26.5 0.0 0.00052 19.8 0.0 2.6 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 CRG84404.1 - 6.5e-06 26.0 0.1 1.9e-05 24.5 0.0 1.8 2 1 0 2 2 2 1 Peptidase S24-like PEN-2 PF10251.9 CRG84404.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase PBP PF01161.20 CRG84405.1 - 3e-09 37.3 0.0 5.1e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Ribosomal_L4 PF00573.22 CRG84406.1 - 7.4e-47 159.5 0.0 1.1e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Sdh5 PF03937.16 CRG84406.1 - 0.11 12.5 0.1 22 5.1 0.0 2.3 2 0 0 2 2 2 0 Flavinator of succinate dehydrogenase ECH_2 PF16113.5 CRG84407.1 - 1.2e-130 435.9 0.0 1.4e-130 435.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 CRG84407.1 - 2.9e-24 85.7 0.0 1.3e-23 83.6 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase SesA PF17107.5 CRG84407.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases FPN1 PF06963.12 CRG84408.1 - 4.8e-134 447.2 17.7 6e-134 446.9 17.7 1.0 1 0 0 1 1 1 1 Ferroportin1 (FPN1) Sulfatase PF00884.23 CRG84410.1 - 2.6e-74 250.4 0.0 3.3e-74 250.1 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF4994 PF16385.5 CRG84410.1 - 0.028 14.3 0.0 0.068 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function Sulfatase_C PF14707.6 CRG84410.1 - 0.1 13.4 0.1 2 9.1 0.1 2.4 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase Sugar_tr PF00083.24 CRG84411.1 - 7.4e-103 344.8 20.8 9.5e-103 344.5 20.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84411.1 - 8.8e-18 64.3 23.3 8.8e-18 64.3 23.3 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily TPR_14 PF13428.6 CRG84411.1 - 0.062 14.1 1.9 2.1 9.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat bZIP_1 PF00170.21 CRG84412.1 - 4.7e-10 39.4 12.5 8.6e-10 38.6 12.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CRG84412.1 - 2.8e-05 24.1 10.4 8.7e-05 22.5 10.4 1.9 1 1 0 1 1 1 1 Basic region leucine zipper NUDE_C PF04880.13 CRG84412.1 - 0.0013 19.2 0.5 0.0013 19.2 0.5 3.1 2 1 1 3 3 3 1 NUDE protein, C-terminal conserved region Herpes_BLRF2 PF05812.12 CRG84412.1 - 0.0093 16.1 0.1 0.023 14.9 0.1 1.7 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein bZIP_Maf PF03131.17 CRG84412.1 - 0.015 15.8 9.0 0.031 14.8 9.0 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor DUF908 PF06012.12 CRG84413.1 - 0.24 10.8 11.0 17 4.7 0.0 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Med13_C PF06333.12 CRG84413.1 - 0.31 10.3 13.2 0.53 9.5 13.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain HNF-1_N PF04814.13 CRG84413.1 - 1.9 9.1 7.6 3.3 8.3 6.8 1.8 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus CBS PF00571.28 CRG84415.1 - 1.2e-21 76.9 4.8 2.8e-10 40.5 0.1 3.7 4 0 0 4 4 4 3 CBS domain CRAL_TRIO PF00650.20 CRG84416.1 - 3e-38 131.0 0.0 4.1e-38 130.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG84416.1 - 2.9e-16 59.4 0.0 6e-16 58.4 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CRG84416.1 - 7.2e-05 23.0 0.0 0.0001 22.5 0.0 1.2 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Pol_alpha_B_N PF08418.10 CRG84417.1 - 8.6e-83 278.1 0.0 1.1e-82 277.7 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 CRG84417.1 - 1.2e-37 129.4 0.1 1.7e-37 128.8 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Apc13p PF05839.11 CRG84418.1 - 3.3e-16 59.2 0.0 5.1e-15 55.4 0.0 2.1 2 0 0 2 2 2 1 Apc13p protein IF-2B PF01008.17 CRG84419.1 - 2.6e-72 243.4 0.1 3.3e-72 243.1 0.1 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Ndc1_Nup PF09531.10 CRG84419.1 - 0.089 11.5 5.2 0.12 11.0 5.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Kinesin PF00225.23 CRG84421.1 - 2.1e-114 381.9 0.7 2.8e-114 381.5 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CRG84421.1 - 1.4e-26 93.2 1.7 2e-26 92.7 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding DUF87 PF01935.17 CRG84421.1 - 0.77 9.8 0.0 0.77 9.8 0.0 3.1 2 1 0 2 2 2 0 Helicase HerA, central domain FapA PF03961.13 CRG84421.1 - 1.1 7.8 9.2 2 6.9 8.6 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A PTPA PF03095.15 CRG84421.1 - 1.2 8.5 5.1 0.96 8.8 2.8 2.0 2 1 0 2 2 2 0 Phosphotyrosyl phosphate activator (PTPA) protein Tau95 PF09734.9 CRG84421.1 - 1.6 9.5 7.7 0.82 10.5 2.1 2.5 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain MukB PF04310.12 CRG84421.1 - 4.9 6.9 5.8 9.7 5.9 3.7 2.4 3 0 0 3 3 3 0 MukB N-terminal PUL PF08324.11 CRG84422.1 - 1.1e-67 228.2 0.3 1.5e-67 227.7 0.3 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 CRG84422.1 - 6.3e-40 136.5 0.0 1.1e-39 135.6 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 CRG84422.1 - 1.3e-14 54.0 0.0 2.7e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 CRG84422.1 - 2.9e-06 27.3 0.1 5.1e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 CRG84422.1 - 0.0067 16.5 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_2 PF13098.6 CRG84422.1 - 0.011 16.2 0.3 0.07 13.6 0.2 2.3 2 1 0 2 2 2 0 Thioredoxin-like domain OST3_OST6 PF04756.13 CRG84422.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HeLo PF14479.6 CRG84425.1 - 1.3e-08 34.9 1.8 3.2e-08 33.7 1.8 1.5 1 0 0 1 1 1 1 Prion-inhibition and propagation Pkinase PF00069.25 CRG84425.1 - 0.11 11.8 0.0 0.47 9.8 0.0 1.9 1 1 1 2 2 2 0 Protein kinase domain Ank_2 PF12796.7 CRG84426.1 - 1.5e-23 83.2 0.3 5.2e-10 39.8 0.0 5.1 4 1 0 4 4 4 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 CRG84426.1 - 2.4e-18 66.5 0.0 5e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 CRG84426.1 - 2.5e-16 59.8 0.8 9.1e-07 29.3 0.0 6.5 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG84426.1 - 2.2e-14 52.1 1.1 0.0062 17.0 0.0 7.3 9 0 0 9 9 9 3 Ankyrin repeat Ank PF00023.30 CRG84426.1 - 5.7e-12 45.5 5.0 0.042 14.3 0.0 7.5 7 1 1 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 CRG84426.1 - 8.4e-11 41.9 2.8 0.00047 20.4 0.0 6.2 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 CRG84426.1 - 5.6e-10 38.9 0.0 1.1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CRG84426.1 - 0.015 14.7 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CRG84426.1 - 0.21 11.2 0.0 0.43 10.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 CRG84426.1 - 0.22 10.4 0.0 1 8.3 0.0 1.9 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase UCH PF00443.29 CRG84428.1 - 9e-36 123.7 0.1 1.4e-35 123.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1604 PF07713.13 CRG84428.1 - 0.16 11.8 1.1 28 4.6 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1604) Alb1 PF09135.11 CRG84429.1 - 4.9e-27 94.9 13.1 1e-26 93.8 13.1 1.6 1 0 0 1 1 1 1 Alb1 FIVAR PF07554.13 CRG84429.1 - 0.048 14.4 2.8 0.11 13.3 2.8 1.6 1 0 0 1 1 1 0 FIVAR domain V_ATPase_I PF01496.19 CRG84429.1 - 1.2 6.9 4.2 1.4 6.7 4.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vps16_N PF04841.13 CRG84430.1 - 1.6e-97 326.9 0.0 2.8e-97 326.1 0.0 1.4 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 CRG84430.1 - 1.4e-88 297.0 0.2 2.1e-88 296.4 0.2 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 CRG84430.1 - 0.05 13.9 0.0 4.6 7.6 0.0 2.9 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain AAA_lid_2 PF17863.1 CRG84431.1 - 2.3e-06 27.3 0.4 5.2e-06 26.2 0.4 1.6 1 0 0 1 1 1 1 AAA lid domain K_channel_TID PF07941.11 CRG84431.1 - 0.056 13.9 2.8 0.12 12.8 2.8 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Bestrophin PF01062.21 CRG84433.1 - 1.2e-53 182.4 0.0 1.8e-53 181.9 0.0 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel FHA PF00498.26 CRG84433.1 - 8.5e-14 51.7 0.0 1.7e-13 50.7 0.0 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 CRG84433.1 - 4.7e-10 39.0 4.2 9.6e-10 38.0 4.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 CRG84433.1 - 5.6e-07 29.8 8.7 1.1e-06 28.9 8.7 1.5 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 CRG84433.1 - 0.00048 20.4 0.0 0.0013 19.0 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_5 PF14634.6 CRG84433.1 - 0.0031 17.4 6.6 0.0059 16.5 6.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 CRG84433.1 - 0.024 14.5 7.7 0.045 13.6 7.7 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 CRG84433.1 - 0.025 14.9 6.0 0.051 13.9 6.0 1.5 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.6 CRG84433.1 - 0.026 14.4 8.4 0.049 13.5 8.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG84433.1 - 0.072 13.1 6.0 0.15 12.1 6.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 CRG84433.1 - 0.15 12.1 2.6 0.3 11.1 2.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 CRG84433.1 - 0.19 12.1 8.6 0.47 10.8 8.6 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain PHD PF00628.29 CRG84433.1 - 0.55 10.2 6.1 1.1 9.2 6.1 1.4 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 CRG84433.1 - 6 6.6 8.5 15 5.3 8.5 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Arm PF00514.23 CRG84435.1 - 4.7e-76 248.8 30.5 2.1e-13 49.8 0.1 11.7 11 1 1 12 12 12 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CRG84435.1 - 9e-19 67.6 16.0 4.8e-05 23.8 0.1 8.8 7 2 2 9 9 9 5 HEAT-like repeat HEAT_2 PF13646.6 CRG84435.1 - 4.9e-17 62.1 12.7 0.0019 18.5 0.4 7.3 3 3 3 7 7 7 4 HEAT repeats HEAT PF02985.22 CRG84435.1 - 1.5e-14 52.8 20.4 0.055 13.8 0.1 9.8 11 0 0 11 11 10 4 HEAT repeat Arm_2 PF04826.13 CRG84435.1 - 6e-13 48.8 5.3 4e-08 33.0 2.9 2.4 1 1 1 2 2 2 2 Armadillo-like Adaptin_N PF01602.20 CRG84435.1 - 5.1e-12 45.1 10.0 5.4e-09 35.2 1.2 3.0 1 1 1 2 2 2 2 Adaptin N terminal region KAP PF05804.12 CRG84435.1 - 3.6e-10 38.7 0.1 9.1e-10 37.3 0.1 1.5 1 1 1 2 2 2 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 CRG84435.1 - 7.9e-09 35.2 3.2 0.00024 20.5 2.1 2.9 2 1 1 3 3 3 2 V-ATPase subunit H Cnd1 PF12717.7 CRG84435.1 - 3.1e-05 24.1 7.1 0.022 14.8 1.0 4.8 2 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 CRG84435.1 - 5.9e-05 23.1 8.2 0.34 10.9 0.1 4.0 1 1 3 4 4 4 2 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 CRG84435.1 - 0.00045 20.3 4.2 5.3 7.2 0.3 4.9 2 1 4 7 7 7 2 V-ATPase subunit H IFRD PF05004.13 CRG84435.1 - 0.00069 18.8 7.7 0.19 10.8 0.5 4.5 2 2 2 4 4 4 2 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.16 CRG84435.1 - 0.00088 19.7 7.2 6.5 7.7 0.4 7.0 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat DUF5578 PF17741.1 CRG84435.1 - 0.0011 18.5 8.8 0.64 9.4 0.0 5.0 3 2 3 6 6 6 1 Family of unknown function (DUF5578) Atx10homo_assoc PF09759.9 CRG84435.1 - 0.0018 18.3 6.0 4.4 7.4 0.0 5.3 3 1 3 6 6 6 1 Spinocerebellar ataxia type 10 protein domain Vac14_Fab1_bd PF12755.7 CRG84435.1 - 0.0027 18.3 0.2 0.66 10.6 0.1 3.3 2 1 2 4 4 3 1 Vacuolar 14 Fab1-binding region UNC45-central PF11701.8 CRG84435.1 - 0.036 14.0 4.6 3.6 7.5 0.2 3.6 3 1 1 4 4 4 0 Myosin-binding striated muscle assembly central Sigma70_r1_1 PF03979.14 CRG84435.1 - 0.13 12.3 1.6 0.36 10.9 0.0 2.5 3 0 0 3 3 2 0 Sigma-70 factor, region 1.1 DAP_B PF07930.12 CRG84435.1 - 0.15 12.1 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 D-aminopeptidase, domain B YqfD PF06898.11 CRG84435.1 - 0.19 10.5 0.0 0.32 9.8 0.0 1.3 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD IBB PF01749.20 CRG84435.1 - 2 8.9 4.1 48 4.5 0.0 4.1 4 1 0 4 4 4 0 Importin beta binding domain EXOSC1 PF10447.9 CRG84436.1 - 7.4e-26 90.9 2.9 1.4e-25 90.0 2.9 1.5 1 0 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 CRG84436.1 - 2.1e-10 40.2 0.2 4.5e-10 39.2 0.2 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region zf-C3HC4_2 PF13923.6 CRG84437.1 - 0.013 15.3 0.5 0.013 15.3 0.5 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG84437.1 - 0.014 15.4 3.5 0.029 14.4 3.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger IBR PF01485.21 CRG84437.1 - 0.024 14.9 4.5 0.22 11.8 0.8 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain PhnA_Zn_Ribbon PF08274.12 CRG84437.1 - 0.03 14.3 0.0 0.071 13.1 0.0 1.6 1 0 0 1 1 1 0 PhnA Zinc-Ribbon zf-RING_5 PF14634.6 CRG84437.1 - 0.046 13.7 4.6 0.092 12.7 4.6 1.6 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 CRG84437.1 - 0.059 13.7 4.6 0.18 12.1 4.8 1.8 1 1 0 1 1 1 0 Ring finger domain FYVE PF01363.21 CRG84437.1 - 0.12 12.5 2.9 0.25 11.5 2.9 1.6 1 1 0 1 1 1 0 FYVE zinc finger zf-C3HC4_4 PF15227.6 CRG84437.1 - 0.16 12.2 1.2 0.41 10.8 0.1 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 CRG84437.1 - 0.25 11.2 4.9 0.98 9.3 4.9 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG84437.1 - 0.26 11.2 5.4 0.2 11.5 1.4 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CRG84437.1 - 1 9.3 5.2 5.6 6.9 5.5 2.0 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prp19 PF08606.11 CRG84438.1 - 4.8e-33 112.9 1.1 9.2e-33 112.1 1.1 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 CRG84438.1 - 4.4e-13 49.3 0.1 3.4e-06 27.3 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG84438.1 - 3.8e-12 46.5 2.9 0.012 16.4 0.0 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat eIF2A PF08662.11 CRG84438.1 - 1.5e-05 25.0 0.1 0.0095 15.8 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CRG84438.1 - 3.3e-05 23.4 0.1 0.014 14.8 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain V_ATPase_I_N PF18670.1 CRG84438.1 - 0.0012 19.2 0.2 0.0026 18.1 0.2 1.6 1 0 0 1 1 1 1 V-type ATPase subunit I, N-terminal domain Cytochrom_D1 PF02239.16 CRG84438.1 - 0.0042 15.7 0.0 0.16 10.5 0.0 2.0 1 1 1 2 2 2 1 Cytochrome D1 heme domain U-box PF04564.15 CRG84438.1 - 0.0091 16.1 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 U-box domain Ge1_WD40 PF16529.5 CRG84438.1 - 0.014 14.4 1.0 0.1 11.5 0.1 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-Nse PF11789.8 CRG84438.1 - 0.026 14.3 0.0 0.084 12.7 0.0 1.8 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit PT-TG PF14449.6 CRG84438.1 - 0.042 13.7 0.1 0.19 11.7 0.1 2.1 1 0 0 1 1 1 0 Pre-toxin TG Frtz PF11768.8 CRG84438.1 - 0.052 11.9 0.0 2 6.7 0.0 2.1 1 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz LrgB PF04172.16 CRG84438.1 - 0.062 12.8 1.3 0.12 11.9 1.3 1.4 1 0 0 1 1 1 0 LrgB-like family PQQ_3 PF13570.6 CRG84438.1 - 3.6 8.2 6.3 19 5.9 0.2 3.6 3 0 0 3 3 3 0 PQQ-like domain Augurin PF15187.6 CRG84439.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Oesophageal cancer-related gene 4 DUF4604 PF15377.6 CRG84440.1 - 2.9e-22 79.9 23.2 3.3e-22 79.7 23.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) SRP-alpha_N PF04086.13 CRG84440.1 - 1.8 8.4 16.6 2.3 8.1 16.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal GTP_EFTU PF00009.27 CRG84441.1 - 1.5e-58 197.5 0.0 3.1e-58 196.5 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 CRG84441.1 - 7.9e-16 57.9 0.0 2.6e-15 56.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 CRG84441.1 - 5.2e-07 29.7 0.0 1.6e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 CRG84441.1 - 4.8e-06 26.9 0.0 1.4e-05 25.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 CRG84441.1 - 0.00014 21.6 0.0 0.00041 20.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV SET PF00856.28 CRG84441.1 - 0.041 14.3 0.2 3.3 8.1 0.0 3.2 3 1 0 3 3 3 0 SET domain MMR_HSR1 PF01926.23 CRG84441.1 - 0.047 13.8 0.0 0.23 11.5 0.0 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase L51_S25_CI-B8 PF05047.16 CRG84442.1 - 6.4e-12 45.2 0.0 1.2e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain U1snRNP70_N PF12220.8 CRG84443.1 - 9.2e-27 93.5 0.2 2e-26 92.5 0.2 1.6 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 CRG84443.1 - 7.6e-18 64.1 0.1 1.8e-17 62.9 0.1 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG84443.1 - 2.5e-05 24.3 0.0 4.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif RL10P_insert PF17777.1 CRG84444.1 - 8.1e-21 73.8 0.0 1.3e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 CRG84444.1 - 1.7e-18 66.6 0.0 3.8e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 MDM10 PF12519.8 CRG84445.1 - 2.3e-146 488.4 4.3 4.6e-127 424.7 2.0 2.0 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 TIM PF00121.18 CRG84447.1 - 4.5e-87 291.5 0.0 5e-87 291.3 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Ank_2 PF12796.7 CRG84448.1 - 0.00022 21.8 0.0 0.0007 20.1 0.0 1.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG84448.1 - 0.018 15.5 0.1 2.3 9.0 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 CRG84448.1 - 0.023 15.3 0.1 6.3 7.5 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.30 CRG84448.1 - 0.052 14.0 0.1 2.9 8.5 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 CRG84448.1 - 0.13 12.6 0.3 0.65 10.4 0.1 2.3 3 0 0 3 3 3 0 Ankyrin repeats (many copies) MFS_1 PF07690.16 CRG84449.1 - 1.9e-34 119.2 18.4 1.9e-34 119.2 18.4 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84449.1 - 4.9e-08 32.3 8.5 4.9e-08 32.3 8.5 2.6 1 1 1 2 2 2 1 Sugar (and other) transporter SRR1 PF07985.12 CRG84450.1 - 4.2e-06 26.7 0.1 1.1e-05 25.4 0.1 1.7 1 1 0 1 1 1 1 SRR1 Pro_isomerase PF00160.21 CRG84451.1 - 5.6e-41 140.5 0.0 1.2e-40 139.3 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD YjeF_N PF03853.15 CRG84451.1 - 3.5e-37 127.9 0.1 5.7e-37 127.2 0.1 1.4 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 CRG84451.1 - 1.5e-06 29.0 1.1 1.5e-06 29.0 1.1 3.4 4 0 0 4 4 4 1 FDF domain Rtf2 PF04641.12 CRG84451.1 - 9.8e-05 21.8 2.4 0.00015 21.3 0.2 2.4 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 CRG84451.1 - 0.0051 16.9 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 CRG84451.1 - 0.017 15.3 0.0 0.046 13.9 0.0 1.8 1 0 0 1 1 1 0 U-box domain PIF1 PF05970.14 CRG84452.1 - 3e-66 224.1 0.1 1.6e-50 172.3 0.0 2.1 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 CRG84452.1 - 2.2e-24 86.2 0.0 4.1e-24 85.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG84452.1 - 5.6e-13 49.5 0.0 1.3e-12 48.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CRG84452.1 - 5e-08 33.3 0.0 1.2e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CRG84452.1 - 5.7e-05 22.9 0.0 0.00018 21.3 0.0 1.9 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_7 PF12775.7 CRG84452.1 - 6.9e-05 22.4 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CRG84452.1 - 9e-05 22.9 0.0 0.0002 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 CRG84452.1 - 0.00033 21.0 0.1 0.0037 17.6 0.0 2.7 3 1 0 3 3 2 1 RNA helicase Viral_helicase1 PF01443.18 CRG84452.1 - 0.00045 20.0 0.0 0.4 10.4 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Herpes_Helicase PF02689.14 CRG84452.1 - 0.00056 18.0 0.0 0.0026 15.8 0.0 1.8 2 0 0 2 2 2 1 Helicase AAA PF00004.29 CRG84452.1 - 0.0036 17.7 0.0 0.0075 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CRG84452.1 - 0.0046 17.1 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CRG84452.1 - 0.0084 15.2 0.0 0.018 14.1 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 CRG84452.1 - 0.0088 15.3 0.0 0.0088 15.3 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 CRG84452.1 - 0.013 14.7 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.6 CRG84452.1 - 0.013 15.5 0.0 0.053 13.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 CRG84452.1 - 0.014 15.4 0.2 0.056 13.4 0.1 2.0 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.9 CRG84452.1 - 0.014 14.3 0.0 0.028 13.4 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_11 PF13086.6 CRG84452.1 - 0.022 14.6 3.2 0.061 13.1 0.0 2.9 3 1 0 3 3 3 0 AAA domain UvrD-helicase PF00580.21 CRG84452.1 - 0.028 14.0 0.1 0.028 14.0 0.1 1.8 1 1 1 2 2 2 0 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 CRG84452.1 - 0.041 13.7 0.1 0.11 12.3 0.1 1.7 1 1 0 1 1 1 0 Helicase ABC_tran PF00005.27 CRG84452.1 - 0.043 14.3 0.1 0.23 11.9 0.1 2.1 1 1 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 CRG84452.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 CRG84452.1 - 0.052 13.6 0.4 0.91 9.5 0.4 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SH3_13 PF18335.1 CRG84452.1 - 0.068 13.0 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain NACHT PF05729.12 CRG84452.1 - 0.077 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain PhoH PF02562.16 CRG84452.1 - 0.079 12.4 0.0 0.25 10.8 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein DUF5605 PF18310.1 CRG84452.1 - 0.17 11.8 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) ATPase_2 PF01637.18 CRG84452.1 - 0.22 11.4 3.5 0.11 12.3 0.4 2.1 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea PTCB-BRCT PF12738.7 CRG84453.1 - 1.6e-48 162.5 1.1 2e-22 78.9 0.1 4.3 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 CRG84453.1 - 1.1e-30 105.9 1.6 1.4e-12 47.8 0.1 4.4 4 0 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CRG84453.1 - 2.5e-12 47.0 0.0 0.00059 20.2 0.0 4.3 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CRG84453.1 - 4.6e-07 30.0 0.7 0.0077 16.5 0.0 4.0 4 0 0 4 4 4 2 DNA ligase 3 BRCT domain Dynamin_N PF00350.23 CRG84455.1 - 9.1e-19 68.1 0.8 5.2e-18 65.7 0.0 2.5 2 1 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 CRG84455.1 - 6.8e-11 42.3 0.0 9.6e-09 35.3 0.0 3.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG84455.1 - 3.4e-06 26.7 0.8 7.3e-05 22.4 0.9 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IIGP PF05049.13 CRG84455.1 - 0.0088 15.1 0.1 0.035 13.2 0.0 1.9 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) PACT_coil_coil PF10495.9 CRG84455.1 - 0.017 15.7 1.9 28 5.4 0.0 4.2 3 1 1 4 4 4 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein TsaE PF02367.17 CRG84455.1 - 0.076 13.0 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CRG84455.1 - 0.076 13.6 0.0 0.24 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF2205 PF10224.9 CRG84455.1 - 0.079 13.0 0.1 0.29 11.2 0.1 2.0 1 0 0 1 1 1 0 Short coiled-coil protein EcoR124_C PF12008.8 CRG84455.1 - 0.44 10.2 5.9 1.3 8.7 0.1 2.6 2 1 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal DUF883 PF05957.13 CRG84455.1 - 0.62 10.7 4.8 49 4.6 0.0 4.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF883) PP2C PF00481.21 CRG84456.1 - 1.8e-62 211.3 0.1 2.5e-50 171.5 0.0 3.4 3 1 0 3 3 3 2 Protein phosphatase 2C Snf7 PF03357.21 CRG84456.1 - 6.2e-35 120.3 17.0 1.5e-34 119.0 16.7 1.8 2 0 0 2 2 2 1 Snf7 Mhr1 PF12829.7 CRG84457.1 - 4.8e-29 100.3 0.2 8.5e-29 99.5 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Atg14 PF10186.9 CRG84458.1 - 8e-16 58.0 11.5 3.3e-13 49.4 0.3 2.2 2 0 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 CRG84458.1 - 1e-06 27.9 0.6 0.085 11.7 0.0 3.1 3 0 0 3 3 3 3 Vacuolar protein sorting 38 APG6 PF04111.12 CRG84458.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Apg6 BARA domain Zn_clus PF00172.18 CRG84459.1 - 5.3e-07 29.7 14.8 8.2e-07 29.0 14.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asp PF00026.23 CRG84460.1 - 3.7e-58 197.4 0.1 4.3e-58 197.2 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 CRG84460.1 - 3.9e-07 30.6 0.1 0.00069 20.2 0.1 3.2 2 1 0 2 2 2 2 Aspartyl protease TAXi_N PF14543.6 CRG84460.1 - 6.2e-06 26.6 0.8 0.00042 20.6 0.3 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 CRG84460.1 - 0.00028 21.4 0.2 0.28 11.8 0.0 4.1 3 2 0 3 3 3 1 gag-polyprotein putative aspartyl protease DUF3443 PF11925.8 CRG84460.1 - 0.00066 18.6 0.0 0.04 12.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3443) DUF4459 PF14673.6 CRG84460.1 - 0.12 12.3 0.0 0.27 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4459) F-box-like PF12937.7 CRG84462.1 - 5.3e-06 26.2 0.5 1.4e-05 24.9 0.1 2.0 2 0 0 2 2 2 1 F-box-like UCH PF00443.29 CRG84463.1 - 7.9e-52 176.3 0.0 1.2e-51 175.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Cyt-b5 PF00173.28 CRG84463.1 - 1.5e-19 69.9 0.1 3e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UCH_1 PF13423.6 CRG84463.1 - 6.5e-15 55.5 1.1 5.4e-12 45.9 0.2 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 CRG84463.1 - 5.1e-08 33.1 0.0 1.5e-07 31.6 0.0 1.8 1 0 0 1 1 1 1 USP8 dimerisation domain Rhodanese PF00581.20 CRG84463.1 - 0.0061 17.1 0.0 0.025 15.1 0.0 2.1 1 0 0 1 1 1 1 Rhodanese-like domain Glyco_hydro_28 PF00295.17 CRG84464.1 - 2.6e-13 49.8 5.3 9e-13 48.0 5.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CRG84464.1 - 5.8e-09 36.1 12.3 4.2e-08 33.3 6.4 3.2 1 1 1 2 2 2 2 Pectate lyase superfamily protein GSH_synth_ATP PF03917.17 CRG84466.1 - 5e-109 364.5 0.0 5.9e-109 364.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CRG84466.1 - 2.6e-24 85.6 0.0 5.3e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Med13_C PF06333.12 CRG84467.1 - 2.1e-89 300.1 1.1 2.1e-89 300.1 1.1 2.5 2 1 1 3 3 3 1 Mediator complex subunit 13 C-terminal domain Med13_N PF11597.8 CRG84467.1 - 5.4e-68 229.7 0.3 9.6e-68 228.9 0.3 1.4 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal MID_MedPIWI PF18296.1 CRG84467.1 - 1.4e-30 106.9 4.9 1.3e-16 61.1 0.0 3.5 3 1 1 4 4 4 2 MID domain of medPIWI NUC153 PF08159.12 CRG84470.1 - 7e-13 48.1 0.9 1.6e-12 47.0 0.9 1.7 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 CRG84470.1 - 0.012 16.4 0.0 52 4.9 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat ATG13 PF10033.9 CRG84471.1 - 7.4e-70 235.4 0.0 1.3e-69 234.6 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 RCC1 PF00415.18 CRG84472.1 - 2.4e-21 76.1 0.3 2.5e-06 28.0 0.0 5.7 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 CRG84472.1 - 1.7e-15 57.2 0.1 1.6e-09 38.0 0.0 3.0 3 0 0 3 3 3 2 BTB/POZ domain RCC1_2 PF13540.6 CRG84472.1 - 9.9e-11 41.2 2.8 1.3e-08 34.4 0.2 4.1 4 0 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 CRG84472.1 - 5.5e-06 26.8 0.1 4.1e-05 24.1 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG84472.1 - 6.9e-06 26.0 0.1 0.35 11.6 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 CRG84472.1 - 0.00045 20.8 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG84472.1 - 0.036 14.4 0.8 6.4 7.2 0.0 3.8 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Ank PF00023.30 CRG84472.1 - 0.065 13.7 0.1 0.63 10.6 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat K_channel_TID PF07941.11 CRG84472.1 - 1.7 9.2 8.1 5.4 7.5 8.1 1.9 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain TCO89 PF10452.9 CRG84473.1 - 0.0001 21.5 6.9 0.033 13.2 0.1 2.9 3 0 0 3 3 3 2 TORC1 subunit TCO89 VHS PF00790.19 CRG84474.1 - 8.2e-40 135.9 2.5 3.6e-39 133.8 0.2 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 CRG84474.1 - 3.1e-16 59.3 1.3 5.1e-16 58.6 1.3 1.3 1 0 0 1 1 1 1 FYVE zinc finger GAT PF03127.14 CRG84474.1 - 2.5e-05 24.5 0.2 0.00028 21.1 0.0 2.5 2 0 0 2 2 2 1 GAT domain UIM PF02809.20 CRG84474.1 - 0.00018 21.2 17.4 0.0038 17.1 2.0 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif Npa1 PF11707.8 CRG84474.1 - 0.039 13.3 0.1 0.071 12.5 0.1 1.3 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal FYVE_2 PF02318.16 CRG84474.1 - 0.096 12.9 0.5 0.22 11.7 0.5 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger OrfB_Zn_ribbon PF07282.11 CRG84474.1 - 0.8 9.7 3.7 2 8.4 3.7 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Pkinase PF00069.25 CRG84476.1 - 6.5e-62 209.3 0.0 8.8e-62 208.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84476.1 - 2.7e-32 112.1 0.0 3.6e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG84476.1 - 4.3e-05 23.0 0.0 7.1e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CRG84476.1 - 0.001 18.5 0.1 0.0018 17.7 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG84476.1 - 0.0036 17.2 1.6 0.0067 16.4 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CRG84476.1 - 0.023 13.7 0.0 0.035 13.0 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 CRG84476.1 - 0.05 12.4 0.0 0.08 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Endonuc_Holl PF10107.9 CRG84476.1 - 0.11 12.3 0.1 0.77 9.6 0.0 2.0 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Cellulase PF00150.18 CRG84477.1 - 1.7e-07 30.9 0.1 1.7e-07 30.9 0.1 2.0 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) EphA2_TM PF14575.6 CRG84477.1 - 0.37 11.7 2.2 0.83 10.6 0.0 2.7 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain OapA_N PF08525.11 CRG84477.1 - 1.5 8.9 3.4 2.3 8.2 3.4 1.3 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif PHY PF00360.20 CRG84479.1 - 1.6e-30 105.8 0.0 3.5e-30 104.7 0.0 1.5 1 0 0 1 1 1 1 Phytochrome region HATPase_c PF02518.26 CRG84479.1 - 1.5e-17 64.1 0.5 3.3e-17 63.0 0.5 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG84479.1 - 5.8e-16 58.7 0.1 2.1e-15 56.8 0.0 2.1 2 1 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 CRG84479.1 - 3.9e-11 42.8 0.8 1.1e-10 41.3 0.8 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 CRG84479.1 - 5.3e-11 43.3 0.0 2e-10 41.4 0.0 2.1 1 0 0 1 1 1 1 GAF domain PAS_2 PF08446.11 CRG84479.1 - 2.2e-09 37.9 0.0 7.9e-09 36.2 0.0 2.1 1 0 0 1 1 1 1 PAS fold HATPase_c_3 PF13589.6 CRG84479.1 - 0.0038 17.1 0.0 0.0081 16.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GNAT_acetyltr_2 PF13718.6 CRG84479.1 - 0.038 13.4 0.0 2.3 7.6 0.0 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Cytochrom_B558a PF05038.13 CRG84480.1 - 0.013 15.0 0.1 0.019 14.5 0.1 1.2 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Amnionless PF14828.6 CRG84480.1 - 0.019 13.9 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Amnionless TMEM154 PF15102.6 CRG84480.1 - 0.036 14.0 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 TMEM154 protein family SIT PF15330.6 CRG84480.1 - 0.052 14.0 0.2 0.11 12.9 0.2 1.7 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4491 PF14898.6 CRG84480.1 - 0.11 13.0 0.5 0.21 12.1 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) Bac_thur_toxin PF01338.18 CRG84480.1 - 0.11 12.0 0.2 0.28 10.6 0.0 1.7 2 0 0 2 2 2 0 Bacillus thuringiensis toxin COX14 PF14880.6 CRG84480.1 - 0.17 11.7 0.4 0.67 9.8 0.1 2.0 1 1 1 2 2 2 0 Cytochrome oxidase c assembly DUF3302 PF11742.8 CRG84480.1 - 1.3 9.2 3.8 0.46 10.6 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3302) SNF2_N PF00176.23 CRG84481.1 - 1.6e-69 234.3 0.2 5.9e-67 225.9 0.0 3.3 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG84481.1 - 1.5e-14 54.2 0.0 3.8e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG84481.1 - 2.3e-07 31.0 0.0 8.3e-07 29.2 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Tub_N PF16322.5 CRG84481.1 - 1.1 9.7 30.3 4.7 7.6 3.4 3.7 3 0 0 3 3 3 0 Tubby N-terminal SIR2 PF02146.17 CRG84482.1 - 2.9e-41 141.3 0.0 1.3e-40 139.2 0.0 1.8 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CRG84482.1 - 0.14 11.9 0.0 0.91 9.3 0.0 2.2 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain Pyridox_ox_2 PF12900.7 CRG84483.1 - 4.8e-40 136.8 0.0 7.6e-40 136.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Peptidase_M24 PF00557.24 CRG84484.1 - 9.8e-50 169.1 0.0 1.6e-49 168.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CRG84484.1 - 1.7e-36 124.7 0.0 2.8e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Creatinase_N PF01321.18 CRG84484.1 - 0.11 13.2 0.0 0.4 11.3 0.0 2.0 1 1 0 1 1 1 0 Creatinase/Prolidase N-terminal domain SUKH_6 PF14568.6 CRG84484.1 - 0.15 12.5 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall Dfp1_Him1_M PF08630.10 CRG84485.1 - 6.4e-44 149.2 0.2 9.6e-43 145.4 0.0 2.5 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 CRG84485.1 - 3.1e-21 75.2 0.0 5.3e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 DBF zinc finger NmrA PF05368.13 CRG84486.1 - 5.7e-31 107.9 1.6 7.2e-31 107.5 1.6 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG84486.1 - 5.6e-18 65.5 0.4 1.3e-17 64.3 0.1 1.7 1 1 1 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG84486.1 - 2.4e-06 27.8 2.1 0.0003 21.0 0.0 2.6 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG84486.1 - 0.00026 20.5 0.6 0.00059 19.4 0.1 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CRG84486.1 - 0.0019 18.2 2.8 0.029 14.5 0.1 2.6 2 1 1 3 3 3 1 Shikimate / quinate 5-dehydrogenase KR PF08659.10 CRG84486.1 - 0.0035 17.3 1.1 0.0076 16.2 0.1 1.9 2 0 0 2 2 2 1 KR domain DapB_N PF01113.20 CRG84486.1 - 0.0048 17.0 1.5 0.017 15.2 0.1 2.4 2 1 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.18 CRG84486.1 - 0.0086 16.3 1.0 0.017 15.3 0.1 1.9 2 0 0 2 2 2 1 TrkA-N domain 3Beta_HSD PF01073.19 CRG84486.1 - 0.027 13.5 0.0 0.049 12.6 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Gp_dh_N PF00044.24 CRG84486.1 - 0.058 13.7 0.1 0.22 11.9 0.0 1.9 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 CRG84486.1 - 0.061 13.8 1.4 0.11 13.0 0.3 1.9 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Pantoate_transf PF02548.15 CRG84487.1 - 1.5e-106 355.5 3.5 1.8e-106 355.3 3.5 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 CRG84487.1 - 9e-08 31.9 3.1 2.4e-07 30.5 3.1 1.7 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Glyco_transf_28 PF03033.20 CRG84487.1 - 0.079 13.0 1.2 0.43 10.6 1.2 2.1 1 1 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain DUF2011 PF09428.10 CRG84488.1 - 8e-30 102.9 1.2 6e-29 100.1 0.0 2.2 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2011) LAMTOR PF15454.6 CRG84489.1 - 1.1e-11 45.1 0.0 2.8e-11 43.9 0.0 1.6 1 1 1 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF3439 PF11921.8 CRG84489.1 - 0.18 11.8 7.6 0.24 11.4 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 CRG84489.1 - 0.36 10.8 16.5 0.47 10.4 16.5 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 CRG84489.1 - 0.98 7.3 5.2 1.1 7.2 5.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 CRG84489.1 - 8.6 4.4 14.0 10 4.2 14.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 UQ_con PF00179.26 CRG84490.1 - 1.5e-36 125.1 0.2 1.7e-36 124.9 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme APG12 PF04110.13 CRG84491.1 - 4.5e-27 94.3 0.0 7.1e-27 93.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 CRG84491.1 - 0.0054 16.9 0.0 0.007 16.5 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like UPF0767 PF15990.5 CRG84492.1 - 0.017 15.2 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 UPF0767 family MFS_1 PF07690.16 CRG84493.1 - 2.4e-42 145.1 45.7 2.4e-42 145.1 45.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84493.1 - 3.1e-18 65.9 31.0 3.9e-17 62.2 14.1 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 CRG84493.1 - 1.2e-05 23.9 24.8 1.4e-05 23.7 22.0 2.2 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF2140 PF09911.9 CRG84493.1 - 0.15 11.6 0.1 0.39 10.3 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) Flavoprotein PF02441.19 CRG84494.1 - 2e-15 56.9 0.0 3.4e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Flavoprotein Ank_4 PF13637.6 CRG84494.1 - 5.2e-06 26.9 0.0 0.31 11.7 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) COesterase PF00135.28 CRG84495.1 - 6.2e-96 322.3 0.0 8.1e-96 321.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG84495.1 - 7.2e-10 39.1 0.6 0.00053 19.9 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG84495.1 - 0.008 15.7 0.1 0.036 13.5 0.1 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CRG84495.1 - 0.058 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Tht1 PF04163.12 CRG84496.1 - 1.4e-05 24.1 7.1 0.00011 21.1 6.9 2.3 1 1 0 1 1 1 1 Tht1-like nuclear fusion protein DUF148 PF02520.17 CRG84496.1 - 0.02 15.0 6.9 0.06 13.5 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function DUF148 DUF16 PF01519.16 CRG84496.1 - 0.092 13.2 8.7 0.14 12.7 1.6 3.5 2 1 2 4 4 4 0 Protein of unknown function DUF16 CENP-K PF11802.8 CRG84496.1 - 0.98 8.9 6.3 1.9 8.0 0.1 2.9 1 1 2 3 3 3 0 Centromere-associated protein K Cytochrom_B562 PF07361.11 CRG84496.1 - 1 10.0 5.3 0.24 12.1 0.4 2.5 2 2 0 2 2 2 0 Cytochrome b562 Ribosomal_L6 PF00347.23 CRG84497.1 - 6.9e-24 84.3 0.1 2.1e-11 44.4 0.0 2.6 2 1 0 2 2 2 2 Ribosomal protein L6 Inositol_P PF00459.25 CRG84498.1 - 2.8e-55 187.8 0.9 7.3e-55 186.4 0.9 1.6 1 1 0 1 1 1 1 Inositol monophosphatase family Surface_antigen PF11054.8 CRG84498.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Sporozoite TA4 surface antigen VHS PF00790.19 CRG84499.1 - 1.5e-23 83.2 0.0 4.1e-23 81.8 0.0 1.7 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 CRG84499.1 - 0.00037 20.8 0.3 0.0009 19.5 0.3 1.7 1 0 0 1 1 1 1 GAT domain ENTH PF01417.20 CRG84499.1 - 0.0005 20.1 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 ENTH domain Pyr_redox_2 PF07992.14 CRG84500.1 - 1.3e-05 24.6 0.0 0.0018 17.5 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG84500.1 - 3.7e-05 23.1 0.0 0.00061 19.1 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG84500.1 - 0.00039 20.9 0.1 0.027 15.0 0.1 3.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG84500.1 - 0.0007 18.8 0.1 0.0012 18.0 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 CRG84500.1 - 0.0011 18.2 0.1 0.0098 15.2 0.3 2.0 1 1 1 2 2 2 1 FAD binding domain FMO-like PF00743.19 CRG84500.1 - 0.0071 14.8 0.0 2.5 6.4 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG84500.1 - 0.013 15.7 0.0 0.036 14.3 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG84500.1 - 0.022 14.4 0.5 7.8 6.0 0.8 2.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG84500.1 - 0.023 13.4 0.0 0.039 12.7 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 CRG84500.1 - 0.026 13.6 0.2 0.039 13.0 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 CRG84500.1 - 0.067 13.2 0.0 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CRG84500.1 - 0.13 11.3 0.0 14 4.7 0.0 2.7 3 0 0 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 CRG84500.1 - 0.15 11.1 0.1 1.3 8.1 0.1 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Thi4 PF01946.17 CRG84500.1 - 0.2 10.9 0.1 0.62 9.3 0.1 1.7 2 0 0 2 2 2 0 Thi4 family 2-Hacid_dh_C PF02826.19 CRG84500.1 - 0.2 11.0 0.0 0.39 10.1 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Tannase PF07519.11 CRG84502.1 - 4.2e-120 401.8 1.0 4.9e-120 401.6 1.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CRG84502.1 - 0.037 13.5 0.7 0.65 9.4 0.4 2.5 2 1 0 2 2 2 0 Prolyl oligopeptidase family Lectin_legB PF00139.19 CRG84504.1 - 0.15 11.6 0.2 0.21 11.1 0.2 1.1 1 0 0 1 1 1 0 Legume lectin domain Gpi16 PF04113.14 CRG84505.1 - 3.6e-240 798.2 0.0 4.4e-240 797.9 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component LUC7 PF03194.15 CRG84506.1 - 9.9e-74 248.2 1.3 1.2e-73 247.9 1.3 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Occludin_ELL PF07303.13 CRG84506.1 - 0.01 16.5 1.5 0.56 11.0 0.3 2.5 3 0 0 3 3 2 0 Occludin homology domain TelA PF05816.11 CRG84506.1 - 0.018 14.1 0.8 0.027 13.6 0.8 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) T4SS PF07996.11 CRG84506.1 - 0.034 14.5 0.6 0.054 13.9 0.2 1.5 2 0 0 2 2 2 0 Type IV secretion system proteins MCPsignal PF00015.21 CRG84506.1 - 0.038 13.8 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Glutaredoxin2_C PF04399.13 CRG84506.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain PIN_8 PF18476.1 CRG84506.1 - 0.074 12.9 0.1 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 PIN like domain DUF2130 PF09903.9 CRG84506.1 - 0.088 12.1 1.1 0.16 11.2 1.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) DASH_Duo1 PF08651.10 CRG84506.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 DASH complex subunit Duo1 HMG_box_5 PF14887.6 CRG84506.1 - 0.12 12.4 0.1 1.6 8.8 0.0 2.3 1 1 1 2 2 2 0 HMG (high mobility group) box 5 DegS PF05384.11 CRG84506.1 - 0.12 11.9 1.5 0.4 10.1 0.3 2.3 1 1 1 2 2 2 0 Sensor protein DegS XhlA PF10779.9 CRG84506.1 - 0.53 10.5 5.2 0.26 11.5 1.5 2.1 2 0 0 2 2 2 0 Haemolysin XhlA GRP PF07172.11 CRG84506.1 - 3.2 8.5 23.0 5.9 7.6 23.0 1.5 1 0 0 1 1 1 0 Glycine rich protein family SPOC PF07744.13 CRG84507.1 - 4.4e-25 88.4 0.0 8.5e-25 87.4 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 CRG84507.1 - 5.5e-21 75.1 0.1 5.5e-21 75.1 0.1 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 CRG84507.1 - 1.5e-10 40.8 12.0 2.7e-10 40.0 12.0 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CRG84507.1 - 0.014 15.0 5.4 0.028 14.0 5.4 1.5 1 0 0 1 1 1 0 PHD-finger PHD_3 PF13922.6 CRG84507.1 - 0.053 13.9 4.2 0.37 11.2 4.2 2.6 1 1 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx Mucin PF01456.17 CRG84507.1 - 0.13 12.2 10.2 0.023 14.7 2.6 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2149 PF09919.9 CRG84507.1 - 1.7 8.9 6.3 7.2 6.9 0.7 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) GBP_C PF02841.14 CRG84508.1 - 0.91 8.9 17.3 1.5 8.1 17.3 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF1043 PF06295.12 CRG84508.1 - 1.5 8.9 7.8 2.8 7.9 7.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF1168 PF06658.12 CRG84508.1 - 2.2 8.1 18.6 0.14 11.9 12.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) FF PF01846.19 CRG84509.1 - 1e-12 48.0 7.5 3.2e-10 40.0 0.1 3.5 3 0 0 3 3 3 2 FF domain WW PF00397.26 CRG84509.1 - 1.8e-09 37.5 2.3 1.8e-09 37.5 2.3 3.4 4 0 0 4 4 4 2 WW domain VGLL4 PF15245.6 CRG84509.1 - 0.075 13.1 2.0 0.17 11.9 2.0 1.6 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 Proteasome PF00227.26 CRG84510.1 - 1.8e-61 207.0 0.2 2.2e-61 206.7 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CRG84510.1 - 2.6e-13 49.4 0.1 8.6e-13 47.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 CRG84510.1 - 0.02 15.0 0.5 0.049 13.7 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 CRG84510.1 - 0.022 14.3 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Epimerase PF01370.21 CRG84511.1 - 7.7e-07 28.8 0.0 4e-06 26.5 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG84511.1 - 3.4e-06 27.1 0.0 5.4e-06 26.4 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding HIM1 PF08732.10 CRG84511.1 - 0.0001 21.9 0.0 0.00014 21.4 0.0 1.2 1 0 0 1 1 1 1 HIM1 Semialdhyde_dh PF01118.24 CRG84511.1 - 0.002 18.6 0.1 0.0067 16.9 0.1 1.9 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 CRG84511.1 - 0.03 13.5 0.2 3 6.9 0.0 2.6 2 2 1 3 3 3 0 Male sterility protein DUF1471 PF07338.13 CRG84511.1 - 0.033 14.2 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1471) FAD_binding_1 PF00667.20 CRG84512.1 - 1.3e-64 217.8 0.0 2.2e-64 217.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain RCC1 PF00415.18 CRG84512.1 - 6.3e-49 164.4 6.2 4e-11 43.4 0.2 7.5 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CRG84512.1 - 6.8e-28 95.9 25.8 1.1e-05 25.0 0.2 7.4 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat NAD_binding_1 PF00175.21 CRG84512.1 - 5.2e-09 36.7 0.0 1.5e-08 35.2 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain POR PF01558.18 CRG84512.1 - 1.4e-08 35.0 0.1 4.6e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 CRG84512.1 - 0.0022 18.3 0.0 0.0055 17.0 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II FtsJ PF01728.19 CRG84514.1 - 7.7e-63 211.8 0.0 1e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase DEAD PF00270.29 CRG84515.1 - 3e-40 137.9 0.0 5.9e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG84515.1 - 3.7e-29 101.3 0.0 2.4e-28 98.7 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG84515.1 - 0.0044 17.0 0.0 0.012 15.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CRG84515.1 - 0.056 13.7 0.5 0.31 11.3 0.5 2.4 1 1 0 1 1 1 0 AAA domain CFIA_Pcf11 PF11526.8 CRG84515.1 - 3.1 8.4 7.9 4.4 7.8 5.8 2.3 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 Zn_clus PF00172.18 CRG84516.1 - 4e-08 33.3 10.4 5.8e-08 32.7 10.4 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BAR PF03114.18 CRG84516.1 - 0.004 16.8 0.2 0.006 16.3 0.2 1.2 1 0 0 1 1 1 1 BAR domain DUF615 PF04751.14 CRG84516.1 - 0.009 16.0 0.3 0.011 15.7 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF615) TRADD_N PF09034.10 CRG84516.1 - 0.049 13.7 0.7 0.079 13.0 0.7 1.4 1 0 0 1 1 1 0 TRADD, N-terminal domain SfsA_N PF17746.1 CRG84516.1 - 0.11 12.7 0.1 0.4 10.9 0.1 1.8 1 1 1 2 2 2 0 SfsA N-terminal OB domain Dickkopf_N PF04706.12 CRG84516.1 - 1.5 9.3 11.0 3.3 8.3 10.6 1.7 1 1 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Peptidase_M20 PF01546.28 CRG84517.1 - 2e-31 109.3 0.0 2.5e-31 109.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG84517.1 - 5e-16 58.6 0.0 1.1e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Fungal_trans PF04082.18 CRG84518.1 - 1.3e-21 76.8 0.0 3.2e-17 62.5 0.0 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84518.1 - 9.2e-08 32.1 9.8 1.7e-07 31.2 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF5643 PF18705.1 CRG84519.1 - 0.035 14.1 0.2 0.057 13.4 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5643) SET PF00856.28 CRG84524.1 - 0.07 13.5 0.1 0.48 10.8 0.0 2.2 2 1 0 2 2 2 0 SET domain PLA2_B PF01735.18 CRG84525.1 - 4.8e-24 84.6 0.0 1.2e-23 83.4 0.0 1.5 1 1 0 1 1 1 1 Lysophospholipase catalytic domain PAD_porph PF04371.15 CRG84526.1 - 2.2e-97 326.2 0.0 2.5e-97 326.0 0.0 1.0 1 0 0 1 1 1 1 Porphyromonas-type peptidyl-arginine deiminase IMS PF00817.20 CRG84527.1 - 1.8e-38 131.9 0.0 3.7e-38 130.9 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 CRG84527.1 - 7.7e-22 77.5 0.3 1.8e-21 76.3 0.3 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain UBM PF14377.6 CRG84527.1 - 7.7e-16 57.0 13.7 2.9e-08 32.9 2.0 4.1 4 0 0 4 4 4 2 Ubiquitin binding region IMS_C PF11799.8 CRG84527.1 - 2.1e-12 47.8 0.0 5.2e-12 46.5 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 CRG84527.1 - 5e-09 36.5 0.0 1.2e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain mCpol PF18182.1 CRG84527.1 - 0.00012 22.3 0.1 0.00051 20.4 0.1 1.9 2 0 0 2 2 2 1 minimal CRISPR polymerase domain BRCT PF00533.26 CRG84527.1 - 0.00016 22.0 0.0 0.00048 20.4 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain IMS_HHH PF11798.8 CRG84527.1 - 0.0013 19.0 0.4 0.0053 17.0 0.0 2.3 2 0 0 2 2 2 1 IMS family HHH motif PTCB-BRCT PF12738.7 CRG84527.1 - 0.0095 15.9 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 twin BRCT domain DUF1805 PF08827.11 CRG84527.1 - 0.02 15.2 0.0 0.083 13.2 0.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) FKBP_C PF00254.28 CRG84528.1 - 1.1e-32 112.2 0.1 3.7e-32 110.5 0.0 1.9 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 CRG84528.1 - 2.2e-30 105.3 4.1 2.2e-30 105.3 4.1 2.8 3 1 0 3 3 3 1 Nucleoplasmin-like domain Pkinase PF00069.25 CRG84529.1 - 7.1e-47 160.0 0.2 3.7e-28 98.6 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84529.1 - 1e-20 74.1 0.0 1.4e-11 44.2 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Ribosomal_L19e PF01280.20 CRG84529.1 - 0.023 14.7 0.3 0.023 14.7 0.3 2.1 2 0 0 2 2 2 0 Ribosomal protein L19e APH PF01636.23 CRG84529.1 - 0.086 12.7 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3591 PF12157.8 CRG84530.1 - 7.5e-173 575.2 4.0 9.5e-173 574.9 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) Methyltransf_15 PF09445.10 CRG84531.1 - 8.5e-52 175.0 0.0 1.1e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 CRG84531.1 - 7.6e-11 42.1 0.0 1.2e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 CRG84531.1 - 8.2e-07 28.8 0.0 1.1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 UPF0020 PF01170.18 CRG84531.1 - 5.6e-05 22.9 0.0 9e-05 22.2 0.0 1.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 CRG84531.1 - 0.0016 19.1 0.0 0.0038 17.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 CRG84531.1 - 0.0017 17.9 0.0 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 MraW methylase family Methyltransf_18 PF12847.7 CRG84531.1 - 0.0042 17.0 0.0 0.0063 16.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG84531.1 - 0.038 13.5 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_11 PF08241.12 CRG84531.1 - 0.051 14.2 0.0 0.086 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 CRG84531.1 - 0.083 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase GRASP55_65 PF04495.14 CRG84533.1 - 1.2e-40 139.0 0.0 7.7e-39 133.2 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 CRG84533.1 - 0.0024 17.7 0.0 0.2 11.5 0.0 2.5 2 0 0 2 2 2 2 PDZ domain ApoO PF09769.9 CRG84534.1 - 1.4e-39 135.0 0.4 3e-39 133.9 0.1 1.7 2 0 0 2 2 2 1 Apolipoprotein O Peptidase_M3 PF01432.20 CRG84535.1 - 6.6e-115 385.0 0.0 9.8e-115 384.4 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Hemocyanin_M PF00372.19 CRG84535.1 - 0.098 11.8 0.0 0.22 10.7 0.0 1.6 1 0 0 1 1 1 0 Hemocyanin, copper containing domain ATP-grasp_5 PF13549.6 CRG84535.1 - 0.21 11.0 0.1 4.7 6.6 0.0 2.6 3 0 0 3 3 3 0 ATP-grasp domain Methyltransf_23 PF13489.6 CRG84536.1 - 7.2e-17 61.7 0.0 9.8e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84536.1 - 7e-12 45.9 0.0 1.9e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG84536.1 - 7.4e-10 39.3 0.0 1.6e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG84536.1 - 2.1e-09 38.0 0.0 6.7e-09 36.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG84536.1 - 2e-07 30.9 0.0 3.1e-06 27.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG84536.1 - 6.1e-05 22.5 0.0 0.0004 19.8 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 CRG84536.1 - 9.8e-05 21.9 0.0 0.0034 16.9 0.0 3.1 4 0 0 4 4 4 1 Putative methyltransferase PrmA PF06325.13 CRG84536.1 - 0.0063 16.0 0.0 0.016 14.6 0.0 1.7 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CRG84536.1 - 0.01 15.6 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_2 PF00891.18 CRG84536.1 - 0.021 14.2 0.0 0.045 13.0 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase domain MTS PF05175.14 CRG84536.1 - 0.032 13.8 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain GidB PF02527.15 CRG84536.1 - 0.038 13.3 0.0 0.082 12.2 0.0 1.5 2 0 0 2 2 2 0 rRNA small subunit methyltransferase G Proteasome PF00227.26 CRG84538.1 - 8.7e-46 155.8 0.0 1.1e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 CRG84538.1 - 1.1e-14 53.6 0.2 1.1e-14 53.6 0.2 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal ANAPC4_WD40 PF12894.7 CRG84540.1 - 8.6e-05 22.8 0.0 0.0011 19.2 0.0 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Syntaxin-6_N PF09177.11 CRG84540.1 - 0.039 14.5 1.0 0.11 13.0 1.0 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal IFP_35_N PF07334.13 CRG84540.1 - 0.073 13.1 3.1 0.2 11.7 0.0 3.0 3 0 0 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus FapA PF03961.13 CRG84540.1 - 0.12 11.0 0.4 0.17 10.4 0.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A YkyA PF10368.9 CRG84540.1 - 0.19 11.4 0.8 0.4 10.3 0.8 1.4 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Fungal_trans PF04082.18 CRG84545.1 - 8.3e-12 44.7 0.0 2e-11 43.5 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84545.1 - 4e-07 30.0 8.5 7.1e-07 29.3 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dioxygenase_C PF00775.21 CRG84548.1 - 1.6e-07 30.9 0.0 3.1e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Dioxygenase Cupin_1 PF00190.22 CRG84549.1 - 8.1e-39 132.6 0.0 4.2e-18 65.4 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CRG84549.1 - 1.9e-29 101.2 0.1 2.8e-15 55.8 0.1 2.5 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CRG84549.1 - 1.5e-12 47.0 0.0 8.2e-05 22.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CRG84549.1 - 3.9e-09 36.5 0.1 3.3e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain MannoseP_isomer PF01050.18 CRG84549.1 - 6e-06 26.2 0.0 0.00021 21.2 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase Cupin_4 PF08007.12 CRG84549.1 - 0.0054 16.2 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 1 Cupin superfamily protein Ectoine_synth PF06339.12 CRG84549.1 - 0.0075 16.5 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 1 Ectoine synthase 3-HAO PF06052.12 CRG84549.1 - 0.011 15.4 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Cupin_6 PF12852.7 CRG84549.1 - 0.028 14.1 0.0 2 8.1 0.0 2.3 2 0 0 2 2 2 0 Cupin cNMP_binding PF00027.29 CRG84549.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain FAD_binding_3 PF01494.19 CRG84550.1 - 2e-57 195.1 0.0 2.5e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG84550.1 - 7.5e-09 35.6 0.1 0.0023 17.6 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG84550.1 - 4.4e-05 22.4 1.0 0.01 14.6 0.2 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox PF00070.27 CRG84550.1 - 0.00038 21.0 0.8 0.77 10.4 0.1 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG84550.1 - 0.0011 18.3 0.1 0.91 8.7 0.0 3.2 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG84550.1 - 0.0012 18.1 0.0 0.0021 17.3 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CRG84550.1 - 0.0023 18.1 0.1 0.013 15.7 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CRG84550.1 - 0.0038 16.5 0.0 0.0094 15.2 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG84550.1 - 0.05 12.9 0.1 0.17 11.2 0.0 1.7 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CRG84550.1 - 0.052 12.6 0.2 0.13 11.3 0.1 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein ApbA PF02558.16 CRG84550.1 - 0.073 12.7 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ABM PF03992.16 CRG84551.1 - 0.03 14.4 0.5 2.7 8.2 0.1 2.3 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase KH_1 PF00013.29 CRG84552.1 - 7.8e-43 144.2 2.2 9.5e-18 63.8 0.2 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 CRG84552.1 - 9.3e-11 41.4 1.0 0.0091 15.8 0.1 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 CRG84552.1 - 5.6e-05 23.1 7.8 0.2 11.8 0.2 3.4 3 0 0 3 3 3 3 NusA-like KH domain KH_4 PF13083.6 CRG84552.1 - 6.6e-05 22.7 0.1 0.55 10.1 0.0 3.3 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 CRG84552.1 - 0.0002 21.3 0.0 0.013 15.5 0.0 2.3 2 0 0 2 2 2 1 KH-like RNA-binding domain DUF4110 PF13422.6 CRG84553.1 - 3.3e-34 116.8 2.7 3.3e-34 116.8 2.7 3.3 4 0 0 4 4 4 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 CRG84553.1 - 1.3e-26 92.4 13.4 1.6e-08 34.4 0.0 6.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 CRG84553.1 - 1.2e-25 89.2 12.3 2.3e-09 37.3 0.1 6.3 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CRG84553.1 - 2e-17 62.7 7.2 4.3e-06 26.6 0.1 6.3 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 CRG84553.1 - 3.3e-15 55.7 7.2 0.00088 19.5 0.2 5.0 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 CRG84553.1 - 1.5e-13 50.0 2.7 0.00014 21.4 0.1 4.8 4 1 0 4 4 4 4 Kelch motif Kelch_2 PF07646.15 CRG84553.1 - 5.1e-13 48.4 9.5 6.9e-05 22.7 0.0 5.9 6 1 0 6 6 6 3 Kelch motif Pyridoxal_deC PF00282.19 CRG84554.1 - 2.6e-23 82.4 0.0 4.2e-23 81.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 CRG84554.1 - 0.0055 15.9 0.0 0.0087 15.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Abhydrolase_1 PF00561.20 CRG84555.1 - 6.1e-14 52.3 0.0 1.5e-13 51.0 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG84555.1 - 1.2e-09 37.8 0.0 3.2e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CRG84555.1 - 0.022 14.2 0.0 0.17 11.4 0.0 2.2 1 1 0 1 1 1 0 Prolyl oligopeptidase family YozE_SAM_like PF06855.12 CRG84555.1 - 0.035 14.3 0.1 6.4 7.0 0.1 2.6 2 0 0 2 2 2 0 YozE SAM-like fold CENP-K PF11802.8 CRG84556.1 - 0.0022 17.7 12.7 0.15 11.6 0.0 2.9 2 1 1 3 3 3 1 Centromere-associated protein K HD_6 PF18019.1 CRG84556.1 - 0.025 14.7 0.4 0.043 13.9 0.0 1.7 2 0 0 2 2 2 0 HD domain Fib_alpha PF08702.10 CRG84556.1 - 0.062 13.5 0.5 0.062 13.5 0.5 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DivIVA PF05103.13 CRG84556.1 - 1 9.5 9.3 1.5 8.9 3.5 2.4 2 0 0 2 2 2 0 DivIVA protein Exonuc_VII_L PF02601.15 CRG84556.1 - 4.4 6.8 13.4 0.71 9.4 0.3 2.6 1 1 1 2 2 2 0 Exonuclease VII, large subunit DEAD PF00270.29 CRG84557.1 - 6.6e-22 78.1 0.0 1.7e-21 76.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG84557.1 - 2.1e-20 73.1 1.2 2.2e-17 63.4 0.0 4.3 4 0 0 4 4 4 1 Helicase conserved C-terminal domain RQC PF09382.10 CRG84557.1 - 2e-19 69.4 0.4 5.9e-19 67.9 0.2 1.9 2 0 0 2 2 2 1 RQC domain RecQ_Zn_bind PF16124.5 CRG84557.1 - 2.2e-16 60.3 7.7 7.9e-16 58.6 7.7 2.1 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 CRG84557.1 - 3.1e-08 33.8 0.0 8.2e-08 32.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HRDC PF00570.23 CRG84557.1 - 3.4e-07 30.1 0.0 1.8e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 HRDC domain NFACT-C PF11923.8 CRG84558.1 - 1.9e-34 117.8 0.0 1.9e-34 117.8 0.0 3.9 4 0 0 4 4 4 1 NFACT protein C-terminal domain FbpA PF05833.11 CRG84558.1 - 2.1e-32 112.5 14.8 2.1e-32 112.5 14.8 2.1 2 1 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 CRG84558.1 - 1.3e-25 90.1 0.0 4.9e-25 88.3 0.0 2.0 2 0 0 2 2 2 1 NFACT protein RNA binding domain Clat_adaptor_s PF01217.20 CRG84559.1 - 3.9e-12 46.3 0.0 1.2e-11 44.7 0.1 1.6 2 0 0 2 2 2 1 Clathrin adaptor complex small chain LegC3_N PF18654.1 CRG84560.1 - 0.25 10.6 25.6 0.72 9.0 4.4 2.4 1 1 1 2 2 2 0 LegC3 N-terminal coiled-coil domain DUF948 PF06103.11 CRG84560.1 - 6.7 7.0 7.7 0.27 11.5 1.4 2.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) V_ATPase_I PF01496.19 CRG84560.1 - 8.8 4.1 8.4 18 3.1 8.4 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ribosomal_L16 PF00252.18 CRG84562.1 - 1.2e-43 148.2 0.1 1.6e-43 147.8 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e ANAPC2 PF08672.11 CRG84565.1 - 6.7e-23 81.0 0.1 1.1e-21 77.0 0.1 2.9 3 0 0 3 3 3 1 Anaphase promoting complex (APC) subunit 2 Cullin PF00888.22 CRG84565.1 - 8.1e-22 77.6 0.2 1.4e-21 76.8 0.2 1.3 1 0 0 1 1 1 1 Cullin family Pkr1 PF08636.10 CRG84567.1 - 1.6e-31 108.3 4.4 2e-31 107.9 4.4 1.1 1 0 0 1 1 1 1 ER protein Pkr1 DUF1761 PF08570.10 CRG84567.1 - 0.019 15.2 1.4 0.035 14.4 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1761) OAD_gamma PF04277.13 CRG84567.1 - 0.02 15.4 0.1 0.04 14.5 0.1 1.6 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TssO PF17561.2 CRG84567.1 - 0.036 14.2 0.3 0.05 13.7 0.3 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssO DUF4834 PF16118.5 CRG84567.1 - 0.075 14.0 0.7 0.18 12.8 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FHIPEP PF00771.20 CRG84567.1 - 0.13 10.7 0.1 0.16 10.4 0.1 1.1 1 0 0 1 1 1 0 FHIPEP family FUSC-like PF12805.7 CRG84567.1 - 0.34 10.0 5.2 0.65 9.0 5.1 1.5 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS Phage_Gp23 PF10669.9 CRG84567.1 - 1 9.7 4.0 4.9 7.5 4.0 1.9 1 1 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Motilin_ghrelin PF04644.12 CRG84567.1 - 3.4 7.5 7.3 8.3 6.3 7.3 1.6 1 0 0 1 1 1 0 Motilin/ghrelin Sugar_tr PF00083.24 CRG84569.1 - 7.4e-118 394.3 21.8 8.9e-118 394.0 21.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84569.1 - 4.4e-22 78.5 44.5 3.5e-20 72.2 34.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG84569.1 - 0.00014 20.4 4.9 0.00014 20.4 4.9 1.9 3 0 0 3 3 3 1 Fungal trichothecene efflux pump (TRI12) zf-C2H2 PF00096.26 CRG84570.1 - 4.4e-05 23.7 3.6 0.18 12.3 0.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG84570.1 - 0.0019 18.9 2.5 0.5 11.3 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger Glyco_hydro_26 PF02156.15 CRG84571.1 - 6.5e-70 236.0 1.7 7.6e-70 235.8 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 26 GTP_EFTU PF00009.27 CRG84572.1 - 2.9e-06 27.0 0.0 6.4e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CRG84572.1 - 0.013 15.4 0.1 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 CRG84572.1 - 0.019 15.4 0.8 0.05 14.0 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain LSM PF01423.22 CRG84573.1 - 1.6e-16 59.7 0.0 3.5e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 LSM domain F-box-like PF12937.7 CRG84573.1 - 0.00021 21.1 0.6 0.001 18.9 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CRG84573.1 - 0.0082 16.0 0.2 0.025 14.4 0.2 1.9 1 0 0 1 1 1 1 F-box domain SM-ATX PF14438.6 CRG84573.1 - 0.011 15.9 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain MTS PF05175.14 CRG84574.1 - 0.029 13.9 0.0 0.077 12.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase small domain Complex1_LYR_2 PF13233.6 CRG84575.1 - 3.2e-20 72.7 0.0 4.2e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 CRG84575.1 - 1.1e-07 31.8 0.0 2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) HA2 PF04408.23 CRG84576.1 - 7.8e-21 74.4 0.1 7.8e-21 74.4 0.1 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CRG84576.1 - 9.3e-13 48.4 0.0 2e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CRG84576.1 - 5e-11 42.9 0.0 1.4e-10 41.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG84576.1 - 8.8e-05 22.3 0.0 0.00023 21.0 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CRG84576.1 - 0.00014 22.2 0.0 0.0004 20.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 CRG84576.1 - 0.0088 15.8 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 CRG84576.1 - 0.019 14.7 0.0 0.055 13.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CRG84576.1 - 0.031 14.6 0.0 0.21 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 CRG84576.1 - 0.051 13.3 0.0 0.16 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 CRG84576.1 - 0.086 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.6 CRG84576.1 - 0.33 11.4 4.1 0.44 11.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain F-box-like PF12937.7 CRG84577.1 - 4.8e-08 32.8 0.1 9.8e-08 31.8 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG84577.1 - 0.00017 21.4 0.2 0.00047 20.0 0.2 1.8 1 0 0 1 1 1 1 F-box domain Mito_carr PF00153.27 CRG84578.1 - 3.5e-62 206.3 2.7 2.3e-19 69.1 0.1 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Lactonase PF10282.9 CRG84580.1 - 1.5e-82 277.6 0.1 1.9e-82 277.3 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PQQ PF01011.21 CRG84580.1 - 0.069 13.1 1.1 24 5.1 0.0 3.8 2 1 1 3 3 3 0 PQQ enzyme repeat PQQ_3 PF13570.6 CRG84580.1 - 6.1 7.5 9.5 31 5.2 3.5 4.4 3 1 0 3 3 3 0 PQQ-like domain TauD PF02668.16 CRG84582.1 - 6.4e-34 118.0 0.0 8.8e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RicinB_lectin_2 PF14200.6 CRG84583.1 - 1.3e-28 99.6 4.9 2.3e-15 57.1 0.8 2.9 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 CRG84583.1 - 1.1e-10 41.8 2.0 2.1e-10 41.0 1.1 1.9 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Bac_rhamnosid6H PF17389.2 CRG84583.1 - 0.0023 17.2 3.6 0.0058 15.9 3.6 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain SUKH_6 PF14568.6 CRG84583.1 - 0.11 13.0 0.2 5.3 7.5 0.0 2.8 2 1 0 2 2 2 0 SMI1-KNR4 cell-wall Amidase PF01425.21 CRG84584.1 - 3.2e-82 276.9 0.0 5.5e-82 276.1 0.0 1.4 1 1 0 1 1 1 1 Amidase SNO PF01174.19 CRG84585.1 - 0.16 11.8 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 SNO glutamine amidotransferase family Acetyltransf_1 PF00583.25 CRG84586.1 - 8.1e-06 26.1 0.3 2.8e-05 24.3 0.3 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CRG84586.1 - 0.00021 21.9 0.0 0.00029 21.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CRG84586.1 - 0.04 14.0 0.0 0.054 13.6 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain KAR9 PF08580.10 CRG84589.1 - 2.8e-230 766.5 5.4 2.8e-230 766.5 5.4 3.0 2 1 1 3 3 3 1 Yeast cortical protein KAR9 Mod_r PF07200.13 CRG84589.1 - 4.1 7.5 5.0 7.9 6.6 0.1 3.5 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Abhydrolase_6 PF12697.7 CRG84590.1 - 2.3e-05 25.1 2.2 6.4e-05 23.7 0.1 2.3 1 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG84591.1 - 5e-33 114.8 0.1 6.7e-33 114.4 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG84591.1 - 1.5e-10 40.8 0.0 2.3e-09 36.9 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG84591.1 - 1.4e-06 29.1 1.3 1.7e-06 28.8 1.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 CRG84591.1 - 0.0011 19.1 0.0 0.0021 18.1 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Esterase PF00756.20 CRG84591.1 - 0.0051 16.5 0.0 0.011 15.4 0.0 1.9 1 1 0 1 1 1 1 Putative esterase Kelch_3 PF13415.6 CRG84591.1 - 0.036 14.4 1.1 0.13 12.5 0.6 2.5 2 1 0 2 2 2 0 Galactose oxidase, central domain tRNA_m1G_MT PF01746.21 CRG84591.1 - 0.056 13.1 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 tRNA (Guanine-1)-methyltransferase Ndr PF03096.14 CRG84591.1 - 0.083 11.6 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Ndr family AOX PF01786.17 CRG84592.1 - 1.1e-98 329.1 2.2 1.3e-98 328.8 2.2 1.1 1 0 0 1 1 1 1 Alternative oxidase Peptidase_S66C PF17676.1 CRG84592.1 - 0.065 13.8 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain Acylphosphatase PF00708.18 CRG84593.1 - 2.7e-27 95.0 1.0 3e-27 94.8 1.0 1.0 1 0 0 1 1 1 1 Acylphosphatase BLUF PF04940.12 CRG84593.1 - 0.00037 20.5 0.1 0.00045 20.3 0.1 1.2 1 0 0 1 1 1 1 Sensors of blue-light using FAD Virulence_RhuM PF13310.6 CRG84593.1 - 0.074 12.3 0.0 0.086 12.1 0.0 1.1 1 0 0 1 1 1 0 Virulence protein RhuM family MBOAT PF03062.19 CRG84594.1 - 1.8e-45 155.8 23.5 4.5e-37 128.2 10.6 2.5 2 1 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family zf-HIT PF04438.16 CRG84596.1 - 1e-09 38.1 9.1 1.7e-09 37.4 9.1 1.3 1 0 0 1 1 1 1 HIT zinc finger JIP_LZII PF16471.5 CRG84597.1 - 0.085 13.0 0.2 0.12 12.5 0.2 1.2 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 CRG84597.1 - 0.54 10.3 2.0 0.89 9.6 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Dopey_N PF04118.14 CRG84598.1 - 4.1e-119 397.3 0.8 1.1e-118 395.8 0.0 2.3 4 0 0 4 4 4 1 Dopey, N-terminal HEAT_EZ PF13513.6 CRG84598.1 - 5.8 7.5 11.1 14 6.3 0.1 5.7 6 0 0 6 6 6 0 HEAT-like repeat Mon1 PF03164.14 CRG84599.1 - 3e-157 523.9 0.0 3.6e-157 523.6 0.0 1.1 1 0 0 1 1 1 1 Trafficking protein Mon1 Sua5_yciO_yrdC PF01300.18 CRG84600.1 - 2.2e-56 190.2 0.0 3.8e-56 189.4 0.0 1.4 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 CRG84600.1 - 9.1e-32 110.4 0.0 2.4e-31 109.1 0.0 1.6 2 0 0 2 2 2 1 Putative GTP-binding controlling metal-binding EHN PF06441.12 CRG84602.1 - 3.9e-28 98.0 0.1 6.9e-28 97.2 0.1 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG84602.1 - 1.8e-08 34.3 1.2 2.7e-08 33.8 0.1 1.8 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG84602.1 - 0.029 15.0 7.6 0.11 13.1 7.6 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase family A_deaminase PF00962.22 CRG84603.1 - 2.8e-78 263.5 0.0 3.4e-78 263.3 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase SpoVS PF04232.12 CRG84604.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) 2Fe-2S_thioredx PF01257.19 CRG84605.1 - 4.4e-60 201.7 0.1 5.5e-60 201.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin SNF2_N PF00176.23 CRG84606.1 - 1.1e-17 63.9 0.0 3.5e-13 49.0 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.17 CRG84606.1 - 4.7e-15 55.8 0.0 9.6e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.31 CRG84606.1 - 3.6e-06 27.3 0.1 8e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 CRG84606.1 - 0.2 11.5 9.5 0.52 10.2 9.5 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CSTF2_hinge PF14327.6 CRG84607.1 - 1.5e-32 111.9 1.3 1.5e-32 111.9 1.3 2.4 3 0 0 3 3 3 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 CRG84607.1 - 2.9e-19 68.7 0.0 4.5e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 CRG84607.1 - 3.8e-15 55.2 12.7 3.8e-15 55.2 12.7 2.3 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 CRG84607.1 - 0.0051 16.9 0.1 0.7 10.0 0.0 2.5 1 1 1 2 2 2 1 RNA recognition motif Spo7_2_N PF15407.6 CRG84607.1 - 0.012 15.3 0.0 0.038 13.6 0.0 1.8 2 0 0 2 2 2 0 Sporulation protein family 7 RRM_occluded PF16842.5 CRG84607.1 - 0.016 15.1 0.0 0.046 13.6 0.0 1.7 1 1 0 1 1 1 0 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 CRG84607.1 - 0.14 12.0 0.0 6.3 6.6 0.0 2.2 1 1 1 2 2 2 0 Rrp7 RRM-like N-terminal domain RRM_5 PF13893.6 CRG84607.1 - 0.2 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Band_7 PF01145.25 CRG84608.1 - 4.6e-22 78.9 5.9 8.8e-22 78.0 5.9 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Ank_2 PF12796.7 CRG84610.1 - 0.0015 19.1 0.4 1.6 9.4 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CRG84610.1 - 0.021 15.3 0.4 0.17 12.4 0.4 2.5 1 1 0 1 1 1 0 Ankyrin repeat IHABP4_N PF16174.5 CRG84610.1 - 0.032 14.8 1.7 0.032 14.8 1.7 2.1 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Ank_4 PF13637.6 CRG84610.1 - 0.082 13.5 0.1 6.7 7.4 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeats (many copies) BUD22 PF09073.10 CRG84610.1 - 0.58 9.5 7.6 0.89 8.8 7.6 1.2 1 0 0 1 1 1 0 BUD22 RSN1_7TM PF02714.15 CRG84611.1 - 5e-84 281.9 25.8 5e-84 281.9 25.8 2.0 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CRG84611.1 - 1.3e-46 158.2 1.6 1.3e-46 158.2 1.6 3.0 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CRG84611.1 - 5.5e-30 104.9 3.8 4.9e-18 66.0 0.0 2.8 2 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 CRG84611.1 - 2.6e-13 50.0 0.0 6.7e-13 48.6 0.0 1.7 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter DUF1845 PF08900.11 CRG84611.1 - 0.1 12.3 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1845) TLV_coat PF00429.19 CRG84611.1 - 2.4 6.7 3.9 4.3 5.9 3.9 1.3 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) MCM PF00493.23 CRG84612.1 - 8.7e-102 339.0 0.0 1.3e-101 338.4 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain VTC PF09359.10 CRG84612.1 - 3.9e-99 331.5 0.0 7.5e-99 330.6 0.0 1.5 1 0 0 1 1 1 1 VTC domain MCM_OB PF17207.3 CRG84612.1 - 2.1e-39 134.3 2.3 3.8e-39 133.4 2.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CRG84612.1 - 7.2e-28 96.8 2.6 7.2e-28 96.8 2.6 2.0 2 0 0 2 2 1 1 MCM AAA-lid domain MCM_N PF14551.6 CRG84612.1 - 8.8e-17 61.6 0.0 3.9e-16 59.5 0.0 2.2 1 0 0 1 1 1 1 MCM N-terminal domain DUF202 PF02656.15 CRG84612.1 - 4e-13 49.6 3.8 8.8e-13 48.5 3.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) AAA_5 PF07728.14 CRG84612.1 - 1.3e-05 25.2 0.0 4e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CRG84612.1 - 3.2e-05 23.4 0.0 0.00047 19.6 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI SPX PF03105.19 CRG84612.1 - 6.4e-05 23.0 0.4 6.4e-05 23.0 0.4 5.0 5 1 1 6 6 6 2 SPX domain AAA_3 PF07726.11 CRG84612.1 - 0.0025 17.7 0.0 0.0075 16.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Myb_DNA-binding PF00249.31 CRG84612.1 - 1.2 9.4 2.8 13 6.1 0.4 3.4 3 0 0 3 3 3 0 Myb-like DNA-binding domain Ribophorin_I PF04597.14 CRG84613.1 - 1e-147 492.9 0.1 1.2e-147 492.7 0.1 1.0 1 0 0 1 1 1 1 Ribophorin I Indigoidine_A PF04227.12 CRG84614.1 - 7.4e-120 399.7 0.3 1.3e-119 398.9 0.3 1.4 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 CRG84614.1 - 7.6e-13 48.4 1.3 1.3e-06 28.0 0.0 2.6 3 0 0 3 3 3 2 pfkB family carbohydrate kinase Flavokinase PF01687.17 CRG84615.1 - 7.2e-21 74.6 0.0 1.5e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Riboflavin kinase Zn_clus PF00172.18 CRG84615.1 - 0.39 10.9 14.9 0.022 14.9 9.2 1.9 3 0 0 3 3 3 0 Fungal Zn(2)-Cys(6) binuclear cluster domain ECH_1 PF00378.20 CRG84616.1 - 1.2e-46 159.1 0.0 1.7e-46 158.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG84616.1 - 2.3e-25 89.8 0.2 1.1e-20 74.4 0.1 2.5 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CRG84616.1 - 0.0027 17.7 0.0 0.037 14.0 0.0 2.2 2 0 0 2 2 2 1 Peptidase family S49 Hexokinase_2 PF03727.16 CRG84617.1 - 4.2e-82 275.2 0.0 5.8e-82 274.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CRG84617.1 - 3.8e-73 245.7 0.0 5e-73 245.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase DUF2587 PF10759.9 CRG84617.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) SIR2 PF02146.17 CRG84619.1 - 8.3e-56 188.7 0.0 1.4e-55 188.0 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 CRG84619.1 - 0.0075 16.0 0.0 0.023 14.4 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain COG4 PF08318.12 CRG84620.1 - 6.4e-124 413.4 0.0 9.3e-124 412.9 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein Ammonium_transp PF00909.21 CRG84621.1 - 2.8e-116 388.5 31.3 3.2e-116 388.3 31.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family E1-E2_ATPase PF00122.20 CRG84622.1 - 4.5e-48 163.2 0.4 4.5e-48 163.2 0.4 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CRG84622.1 - 4.6e-44 150.3 0.3 4.6e-44 150.3 0.3 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CRG84622.1 - 1.8e-21 77.4 0.1 2.3e-20 73.8 0.0 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG84622.1 - 8.9e-20 70.2 0.5 2.4e-19 68.8 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CRG84622.1 - 3.6e-13 49.4 0.0 7.3e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CRG84622.1 - 1.5e-05 24.9 1.9 1.7e-05 24.7 0.7 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rad21_Rec8_N PF04825.13 CRG84623.1 - 1.4e-37 128.2 0.7 2.7e-37 127.3 0.1 1.8 2 0 0 2 2 2 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 CRG84623.1 - 1.8e-08 33.6 0.1 5.7e-08 31.9 0.1 1.9 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein MFS_1 PF07690.16 CRG84626.1 - 1.5e-40 139.2 36.7 4.6e-40 137.6 31.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Abhydrolase_1 PF00561.20 CRG84627.1 - 2.9e-18 66.5 0.1 4.4e-17 62.6 0.1 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG84627.1 - 1.2e-13 52.3 0.6 1.6e-13 51.8 0.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG84627.1 - 5.6e-11 42.2 0.0 1.1e-10 41.2 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 AXE1 PF05448.12 CRG84627.1 - 0.071 11.8 0.1 0.13 10.9 0.1 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Peptidase_S10 PF00450.22 CRG84629.1 - 8e-92 308.8 3.6 1.6e-91 307.8 3.6 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase TLP1_add_C PF18313.1 CRG84630.1 - 1.2e-24 86.0 0.0 2.9e-24 84.8 0.0 1.6 2 0 0 2 2 2 1 Thiolase-like protein type 1 additional C-terminal domain Thiolase_C PF02803.18 CRG84630.1 - 0.13 11.9 0.0 0.45 10.2 0.0 1.8 2 0 0 2 2 2 0 Thiolase, C-terminal domain ANAPC4_WD40 PF12894.7 CRG84631.1 - 2.6e-06 27.6 0.3 0.28 11.5 0.2 4.6 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG84631.1 - 0.003 18.3 9.5 0.15 13.0 0.0 5.8 6 0 0 6 6 6 1 WD domain, G-beta repeat STIMATE PF12400.8 CRG84633.1 - 7.2e-39 133.2 6.5 1.3e-38 132.3 6.5 1.4 1 0 0 1 1 1 1 STIMATE family RRM_1 PF00076.22 CRG84635.1 - 4.8e-14 51.9 0.2 8.9e-14 51.1 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG84635.1 - 0.00024 20.7 0.0 0.00026 20.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Vps62 PF06101.11 CRG84637.1 - 1e-10 40.6 0.3 1.5e-10 40.0 0.3 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 TFIIIC_sub6 PF10419.9 CRG84638.1 - 1e-22 79.8 0.0 2.2e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain FOG_N PF15888.5 CRG84638.1 - 1 9.8 4.2 0.62 10.4 0.2 2.6 3 0 0 3 3 3 0 Folded gastrulation N-terminus HPS6 PF15702.5 CRG84639.1 - 0.27 9.2 0.1 0.29 9.1 0.1 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 6 protein ELFV_dehydrog PF00208.21 CRG84640.1 - 1.3e-66 224.8 0.0 1.8e-66 224.3 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 CRG84640.1 - 8.7e-18 63.3 0.1 4.5e-12 44.4 0.0 2.3 2 1 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 CRG84640.1 - 0.0072 16.2 0.0 0.041 13.8 0.0 2.1 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Interferon PF00143.19 CRG84640.1 - 0.11 12.7 0.3 0.25 11.5 0.0 1.8 2 0 0 2 2 2 0 Interferon alpha/beta domain PPR_2 PF13041.6 CRG84641.1 - 0.0016 18.6 0.1 0.99 9.6 0.0 3.4 3 0 0 3 3 3 2 PPR repeat family WD40 PF00400.32 CRG84642.1 - 3.8e-32 109.8 25.9 4.6e-05 24.1 0.2 10.9 10 0 0 10 10 10 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG84642.1 - 2.3e-19 69.5 3.8 6e-06 26.5 0.0 7.0 4 3 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_S18 PF01084.20 CRG84642.1 - 5.2e-14 52.2 0.8 1.6e-13 50.6 0.2 2.2 2 0 0 2 2 2 1 Ribosomal protein S18 Cro PF09048.10 CRG84642.1 - 0.088 12.9 0.1 1 9.4 0.0 2.4 2 0 0 2 2 2 0 Cro SAGA-Tad1 PF12767.7 CRG84643.1 - 1.8e-56 191.5 0.0 3.6e-56 190.5 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit FUSC_2 PF13515.6 CRG84643.1 - 4.5e-31 107.6 8.5 4.5e-31 107.6 8.5 2.9 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 CRG84643.1 - 5.5e-05 23.1 0.8 5.5e-05 23.1 0.8 2.1 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 Phage_holin_Dp1 PF16938.5 CRG84643.1 - 0.031 14.5 1.4 0.12 12.6 0.1 2.6 2 0 0 2 2 2 0 Putative phage holin Dp-1 ALMT PF11744.8 CRG84643.1 - 0.8 8.5 22.4 0.44 9.3 8.4 4.3 4 2 0 4 4 4 0 Aluminium activated malate transporter PRP1_N PF06424.12 CRG84645.1 - 9.3e-54 181.9 10.0 2.1e-53 180.7 10.0 1.7 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 CRG84645.1 - 2.6e-25 86.9 29.3 1.6e-05 25.3 0.3 12.8 5 3 10 15 15 14 6 Tetratricopeptide repeat TPR_19 PF14559.6 CRG84645.1 - 2.9e-25 88.6 9.0 5.7e-06 26.7 0.2 9.6 6 2 3 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 CRG84645.1 - 5.3e-13 48.0 8.2 0.029 14.5 0.0 8.3 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 CRG84645.1 - 1.4e-11 44.9 13.9 0.0014 19.3 0.0 7.3 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 CRG84645.1 - 9.2e-11 41.2 1.4 0.17 11.6 0.0 7.3 7 1 1 8 8 8 3 TPR repeat TPR_8 PF13181.6 CRG84645.1 - 1.2e-09 37.6 2.8 0.21 11.9 0.0 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 CRG84645.1 - 4.3e-08 32.6 4.0 0.02 14.7 0.0 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG84645.1 - 1.8e-06 27.9 4.1 12 6.6 0.0 7.9 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 CRG84645.1 - 0.00046 20.3 6.7 0.39 10.9 0.0 5.8 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 CRG84645.1 - 0.00053 19.7 13.2 0.39 10.4 0.8 4.7 2 1 2 4 4 4 2 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 CRG84645.1 - 0.001 19.3 3.7 0.38 11.1 0.0 5.7 6 1 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG84645.1 - 0.0094 16.2 0.4 6.9 7.0 0.0 4.3 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 ZNRF_3_ecto PF18212.1 CRG84645.1 - 0.019 15.0 0.1 12 5.9 0.0 4.6 5 1 0 5 5 5 0 ZNRF-3 Ectodomain Suf PF05843.14 CRG84645.1 - 0.098 12.6 2.5 18 5.2 0.0 3.8 3 1 0 3 3 3 0 Suppressor of forked protein (Suf) TPR_7 PF13176.6 CRG84645.1 - 1.1 9.4 5.2 16 5.8 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat RabGAP-TBC PF00566.18 CRG84646.1 - 2.5e-52 177.7 0.0 5.8e-52 176.5 0.0 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RRM_1 PF00076.22 CRG84647.1 - 2.1e-33 113.9 0.2 1.1e-15 57.1 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG84647.1 - 1.3e-10 41.2 0.3 0.00027 21.0 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 CRG84647.1 - 0.014 15.4 0.0 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif Nup35_RRM_2 PF14605.6 CRG84647.1 - 0.029 14.4 0.0 6.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Med14 PF08638.11 CRG84648.1 - 1.1e-64 217.4 0.4 1.7e-64 216.8 0.4 1.3 1 0 0 1 1 1 1 Mediator complex subunit MED14 ATG22 PF11700.8 CRG84649.1 - 3.5e-200 665.7 10.0 4e-200 665.5 10.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 CRG84649.1 - 2e-10 40.2 39.7 1.6e-05 24.1 5.5 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 CRG84649.1 - 0.00055 18.6 24.3 0.04 12.5 9.0 2.7 2 1 0 2 2 2 2 MFS/sugar transport protein Thioredoxin PF00085.20 CRG84650.1 - 3.5e-63 210.0 1.5 4.4e-31 106.9 0.0 4.2 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 CRG84650.1 - 1.7e-48 165.0 1.3 7e-37 127.1 0.4 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 CRG84650.1 - 1.3e-10 41.1 2.8 0.00036 20.0 0.0 3.3 2 1 0 3 3 3 3 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 CRG84650.1 - 5.1e-10 38.9 0.6 1.2e-09 37.7 0.6 1.7 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_2 PF13098.6 CRG84650.1 - 1.8e-08 34.8 0.7 0.017 15.6 0.0 3.7 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CRG84650.1 - 4.3e-08 33.2 0.0 0.011 16.0 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like AhpC-TSA PF00578.21 CRG84650.1 - 4.5e-08 33.1 0.7 0.0017 18.3 0.2 3.4 3 1 0 3 3 3 2 AhpC/TSA family Thioredoxin_8 PF13905.6 CRG84650.1 - 5e-08 33.2 0.0 0.038 14.3 0.0 3.4 3 0 0 3 3 3 2 Thioredoxin-like Redoxin PF08534.10 CRG84650.1 - 6.1e-07 29.3 2.6 0.51 10.0 0.1 3.6 3 0 0 3 3 3 3 Redoxin Thioredoxin_3 PF13192.6 CRG84650.1 - 0.036 14.1 0.1 0.57 10.3 0.1 2.6 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_4 PF13462.6 CRG84650.1 - 0.22 11.7 3.5 7.1 6.8 0.1 3.8 4 2 0 4 4 4 0 Thioredoxin UDG PF03167.19 CRG84651.1 - 3.5e-22 79.1 0.1 5.5e-22 78.4 0.1 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Actin PF00022.19 CRG84653.1 - 1.9e-147 491.2 0.0 2.1e-147 491.0 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CRG84653.1 - 0.042 12.7 0.0 9.7 4.9 0.0 2.7 3 0 0 3 3 3 0 MreB/Mbl protein FtsA PF14450.6 CRG84653.1 - 0.15 12.5 0.1 0.5 10.8 0.1 1.7 2 1 0 2 2 2 0 Cell division protein FtsA Hep_59 PF07052.11 CRG84654.1 - 2.1e-18 67.0 1.3 2.1e-18 67.0 1.3 2.9 3 1 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 HAUS6_N PF14661.6 CRG84654.1 - 5.7 6.4 7.5 0.63 9.6 1.7 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TRP PF06011.12 CRG84655.1 - 6e-136 453.6 16.9 7.6e-136 453.2 16.9 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CRG84655.1 - 1.6e-38 132.2 0.6 2.9e-38 131.3 0.6 1.5 1 0 0 1 1 1 1 ML-like domain Na_H_antiport_2 PF13726.6 CRG84655.1 - 1.6 8.9 10.8 0.19 11.9 0.3 3.6 3 0 0 3 3 3 0 Na+-H+ antiporter family DNA_pol_E_B PF04042.16 CRG84656.1 - 5.7e-49 166.3 0.1 8.3e-49 165.8 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B SHNi-TPR PF10516.9 CRG84657.1 - 3.2e-14 52.1 0.3 3.2e-14 52.1 0.3 3.4 4 0 0 4 4 4 1 SHNi-TPR TPR_12 PF13424.6 CRG84657.1 - 0.13 12.5 3.2 11 6.4 0.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Snapin_Pallidin PF14712.6 CRG84657.1 - 0.14 12.6 5.9 0.33 11.4 1.1 3.2 3 0 0 3 3 3 0 Snapin/Pallidin TPR_1 PF00515.28 CRG84657.1 - 0.14 12.0 1.7 23 5.0 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CRG84657.1 - 0.15 12.4 7.8 1.8 9.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 CRG84657.1 - 0.42 10.6 3.5 31 4.6 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF948 PF06103.11 CRG84657.1 - 1.3 9.3 3.5 4.6 7.6 0.1 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 CRG84657.1 - 7.9 6.5 7.6 3.5 7.7 2.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) ODC_AZ PF02100.17 CRG84658.1 - 1.5e-30 105.5 0.0 2.7e-30 104.7 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Yippee-Mis18 PF03226.14 CRG84658.1 - 4.6e-22 78.2 2.5 1.4e-21 76.7 2.0 1.9 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CRG84658.1 - 0.00062 20.0 0.8 0.96 9.7 0.0 2.6 3 0 0 3 3 3 2 C-terminal domain of RIG-I Transp_Tc5_C PF04236.15 CRG84658.1 - 0.12 12.8 1.5 0.28 11.6 0.1 2.3 3 0 0 3 3 3 0 Tc5 transposase C-terminal domain DUF5594 PF18057.1 CRG84658.1 - 0.15 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5594) DWNN PF08783.11 CRG84659.1 - 1.9e-34 117.8 0.0 4.1e-34 116.7 0.0 1.6 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 CRG84659.1 - 3.6e-08 33.1 5.0 6.4e-08 32.3 5.0 1.4 1 0 0 1 1 1 1 Zinc knuckle Dicty_REP PF05086.12 CRG84659.1 - 0.0008 17.5 5.4 0.0011 17.1 5.4 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein zf-CCHC PF00098.23 CRG84659.1 - 0.0019 18.2 0.7 0.0041 17.1 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 CRG84659.1 - 0.0047 16.7 9.0 0.0098 15.7 9.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CRG84659.1 - 0.18 11.6 4.7 0.44 10.4 4.7 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_2 PF13639.6 CRG84659.1 - 0.22 11.9 7.1 0.49 10.8 7.1 1.6 1 0 0 1 1 1 0 Ring finger domain Virul_Fac PF10139.9 CRG84659.1 - 0.36 9.0 2.5 0.55 8.4 2.5 1.2 1 0 0 1 1 1 0 Putative bacterial virulence factor Hamartin PF04388.12 CRG84659.1 - 1.8 7.1 9.8 2.4 6.7 9.8 1.2 1 0 0 1 1 1 0 Hamartin protein zf-RING_5 PF14634.6 CRG84659.1 - 3.9 7.5 12.2 0.23 11.5 6.0 2.1 2 0 0 2 2 2 0 zinc-RING finger domain TP53IP5 PF15331.6 CRG84659.1 - 4.6 7.3 9.8 9.8 6.3 9.8 1.5 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 zf-C3HC4_4 PF15227.6 CRG84659.1 - 6.1 7.1 9.9 17 5.7 9.9 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING His_biosynth PF00977.21 CRG84660.1 - 2.2e-46 158.1 1.2 6.3e-46 156.7 1.2 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 CRG84660.1 - 2.3e-24 86.2 0.0 3.6e-24 85.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 CRG84660.1 - 2.3e-11 43.9 0.0 2.2e-10 40.7 0.0 2.1 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 CRG84660.1 - 1.3e-08 34.7 0.0 3.7e-08 33.2 0.0 1.8 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 CRG84660.1 - 0.017 14.9 0.2 0.91 9.2 0.0 2.3 2 0 0 2 2 2 0 Peptidase C26 dCMP_cyt_deam_1 PF00383.23 CRG84662.1 - 4.9e-18 64.9 0.0 8.1e-18 64.2 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CRG84662.1 - 3.4e-06 26.8 0.0 6.3e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 CRG84662.1 - 0.0081 16.7 0.0 0.022 15.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 CRG84662.1 - 0.033 13.8 0.0 0.07 12.8 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase ATG7_N PF16420.5 CRG84663.1 - 2.7e-104 349.1 0.0 3.4e-104 348.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 CRG84663.1 - 1.7e-45 155.3 0.0 2.5e-45 154.7 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 CRG84663.1 - 0.016 15.3 0.0 0.29 11.2 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase COPIIcoated_ERV PF07970.12 CRG84663.1 - 0.14 12.0 0.2 0.24 11.2 0.2 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum vesicle transporter ApbA PF02558.16 CRG84663.1 - 0.23 11.1 0.2 1 9.0 0.0 2.1 2 1 1 3 3 3 0 Ketopantoate reductase PanE/ApbA FtsJ PF01728.19 CRG84664.1 - 1.4e-58 197.9 0.0 1.7e-58 197.6 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 CRG84664.1 - 0.0053 16.6 0.0 0.013 15.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG84664.1 - 0.0054 16.5 0.0 0.1 12.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG84664.1 - 0.036 14.8 0.0 0.22 12.2 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain DEAD PF00270.29 CRG84665.1 - 5.5e-49 166.3 0.0 3.3e-48 163.8 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG84665.1 - 1.5e-31 109.0 0.1 8.7e-30 103.3 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG84665.1 - 2.2e-06 27.8 0.0 5.4e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CRG84665.1 - 0.00023 20.6 7.8 0.00027 20.4 0.1 2.3 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 CRG84665.1 - 0.0053 16.0 0.0 0.011 14.9 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Rft-1 PF04506.13 CRG84666.1 - 1.4e-138 462.9 12.9 1.6e-138 462.7 12.9 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 CRG84666.1 - 3.2e-07 30.0 21.1 1.1e-05 25.0 3.6 3.1 3 0 0 3 3 3 3 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.6 CRG84666.1 - 0.00027 21.0 1.0 0.00027 21.0 1.0 2.8 2 1 0 2 2 2 1 Polysaccharide biosynthesis C-terminal domain Polysacc_synt_3 PF13440.6 CRG84666.1 - 0.012 14.9 20.1 1.3 8.2 5.9 3.3 1 1 0 2 2 2 0 Polysaccharide biosynthesis protein OST3_OST6 PF04756.13 CRG84667.1 - 2e-104 349.0 0.0 2.6e-104 348.7 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family HXXEE PF13787.6 CRG84667.1 - 0.011 16.5 1.1 0.031 15.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif Thioredoxin PF00085.20 CRG84667.1 - 0.052 13.5 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin BaxI_1 PF12811.7 CRG84667.1 - 0.18 11.3 6.1 0.28 10.7 6.1 1.2 1 0 0 1 1 1 0 Bax inhibitor 1 like QCR10 PF09796.9 CRG84667.1 - 1.4 9.1 4.3 5.4 7.2 0.0 3.3 2 1 1 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) GAS PF13851.6 CRG84668.1 - 0.37 10.1 42.1 0.055 12.8 7.0 3.7 2 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding Rep_fac-A_C PF08646.10 CRG84669.1 - 2.4e-52 176.6 3.7 6.1e-51 172.0 1.5 2.4 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 CRG84669.1 - 6.6e-38 128.6 0.4 2.4e-37 126.8 0.2 2.0 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 CRG84669.1 - 7.8e-23 80.4 0.0 2e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 CRG84669.1 - 5.9e-13 48.6 0.0 5.8e-09 35.8 0.0 3.6 3 0 0 3 3 3 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 CRG84669.1 - 0.00061 19.6 0.4 0.025 14.3 0.1 2.8 3 0 0 3 3 3 1 Cell division control protein 24, OB domain 3 UCH PF00443.29 CRG84671.1 - 6.1e-39 134.1 0.0 9.4e-39 133.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 CRG84671.1 - 1.7e-24 85.3 1.2 2.7e-23 81.5 0.1 2.7 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 CRG84671.1 - 1.2e-22 80.0 13.1 2.2e-20 72.7 1.2 3.2 2 1 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UBA PF00627.31 CRG84671.1 - 1.9e-17 62.8 0.1 2.8e-10 39.9 0.0 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 CRG84671.1 - 2.2e-16 60.4 0.7 1.5e-14 54.3 0.0 3.2 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase HEAT_2 PF13646.6 CRG84671.1 - 0.15 12.5 0.0 0.41 11.1 0.0 1.7 1 0 0 1 1 1 0 HEAT repeats zf-RING_UBOX PF13445.6 CRG84671.1 - 0.74 9.9 6.7 3.5 7.7 3.0 3.5 3 0 0 3 3 3 0 RING-type zinc-finger Aldedh PF00171.22 CRG84673.1 - 1.6e-10 40.1 8.5 7.3e-09 34.7 4.2 2.8 2 1 0 2 2 2 2 Aldehyde dehydrogenase family Ribosomal_L18 PF17135.4 CRG84674.1 - 7.3e-95 315.7 3.6 9.8e-95 315.3 3.6 1.2 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Mito_carr PF00153.27 CRG84674.1 - 3.6e-67 222.3 0.8 1.8e-21 75.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CRG84674.1 - 0.00016 21.0 0.1 0.044 12.9 0.0 2.9 3 1 0 3 3 3 2 Gammaproteobacterial serine protease Ribosomal_L27A PF00828.19 CRG84674.1 - 0.00047 20.8 0.0 0.001 19.8 0.0 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A RRM_1 PF00076.22 CRG84675.1 - 2.1e-12 46.7 0.0 2.8e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG84675.1 - 0.00056 19.9 0.0 0.00077 19.4 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Atrophin-1 PF03154.15 CRG84675.1 - 3 6.0 16.0 4.5 5.4 16.0 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF1473 PF07341.11 CRG84676.1 - 0.095 12.5 0.0 0.18 11.6 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1473) FAD_binding_4 PF01565.23 CRG84677.1 - 6.9e-06 25.9 0.0 9.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain MFS_1 PF07690.16 CRG84678.1 - 1.7e-10 40.4 20.6 2.9e-09 36.3 14.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84678.1 - 0.00011 21.2 0.8 0.00011 21.2 0.8 2.1 1 1 1 2 2 2 1 Sugar (and other) transporter SirB PF04247.12 CRG84678.1 - 0.13 12.4 3.9 0.2 11.7 3.9 1.3 1 0 0 1 1 1 0 Invasion gene expression up-regulator, SirB Chorion_2 PF03964.15 CRG84680.1 - 2.3 9.1 13.1 5.9 7.8 3.8 2.2 1 1 1 2 2 2 0 Chorion family 2 NmrA PF05368.13 CRG84681.1 - 3.1e-56 190.6 1.1 3.7e-56 190.3 1.1 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG84681.1 - 3.3e-15 56.4 0.0 4.7e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG84681.1 - 5.3e-06 25.6 0.1 7.4e-06 25.2 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG84681.1 - 4.3e-05 23.1 0.0 6.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CRG84681.1 - 0.0057 16.8 0.1 0.013 15.6 0.1 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Polysacc_synt_2 PF02719.15 CRG84681.1 - 0.014 14.5 0.0 0.021 14.0 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TrkA_N PF02254.18 CRG84681.1 - 0.081 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain GDP_Man_Dehyd PF16363.5 CRG84681.1 - 0.082 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 CRG84681.1 - 0.14 12.6 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DUF775 PF05603.12 CRG84682.1 - 0.045 13.3 0.2 0.045 13.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF4106 PF13388.6 CRG84682.1 - 2.2 7.4 7.3 2.3 7.3 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) ABC_tran PF00005.27 CRG84683.1 - 4e-49 166.6 0.1 2.3e-29 102.7 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG84683.1 - 1.5e-30 106.8 31.6 3.6e-23 82.6 12.2 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG84683.1 - 2.2e-10 40.4 7.6 0.0037 16.7 0.1 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG84683.1 - 8e-07 29.2 1.2 0.014 15.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG84683.1 - 1.2e-06 28.1 1.0 0.0099 15.6 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 CRG84683.1 - 1.4e-06 28.6 0.1 0.018 15.3 0.0 2.8 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CRG84683.1 - 0.00064 19.7 0.6 0.54 10.1 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 CRG84683.1 - 0.001 19.5 0.0 3 8.3 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CRG84683.1 - 0.0018 18.4 0.2 1.3 9.2 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 CRG84683.1 - 0.0022 17.9 0.0 0.081 12.8 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_7 PF12775.7 CRG84683.1 - 0.0039 16.7 0.2 0.38 10.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 CRG84683.1 - 0.0053 17.2 0.1 1.8 8.9 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain T2SSE PF00437.20 CRG84683.1 - 0.0072 15.4 0.3 1.8 7.6 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_15 PF13175.6 CRG84683.1 - 0.0073 16.1 0.2 3.1 7.4 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain ABC_ATPase PF09818.9 CRG84683.1 - 0.021 13.7 5.7 0.87 8.3 0.0 3.3 3 0 0 3 3 3 0 Predicted ATPase of the ABC class AAA_23 PF13476.6 CRG84683.1 - 0.022 15.3 11.2 0.38 11.2 0.2 3.1 2 1 0 2 2 2 0 AAA domain cobW PF02492.19 CRG84683.1 - 0.027 14.1 1.9 0.85 9.2 0.1 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 CRG84683.1 - 0.046 13.1 0.5 7.7 5.8 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family NB-ARC PF00931.22 CRG84683.1 - 0.057 12.6 0.3 5 6.2 0.0 2.8 3 0 0 3 3 3 0 NB-ARC domain Zeta_toxin PF06414.12 CRG84683.1 - 0.071 12.4 0.1 5.8 6.1 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 CRG84683.1 - 0.095 12.3 0.3 2.7 7.5 0.1 2.9 3 0 0 3 3 3 0 AAA domain Dynamin_N PF00350.23 CRG84683.1 - 0.12 12.4 0.4 20 5.2 0.0 2.5 2 0 0 2 2 2 0 Dynamin family AAA_5 PF07728.14 CRG84683.1 - 0.13 12.2 1.2 3.4 7.7 0.1 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) FKBP_N_2 PF18023.1 CRG84683.1 - 0.18 11.9 0.2 0.62 10.2 0.1 1.9 2 0 0 2 2 2 0 BDBT FKBP like N-terminal DUF87 PF01935.17 CRG84683.1 - 4.2 7.4 5.7 3.5 7.7 0.6 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain DUF3328 PF11807.8 CRG84685.1 - 5.6e-19 68.8 0.0 7.6e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Peptidase_M3 PF01432.20 CRG84736.1 - 2.7e-137 458.8 1.4 3.2e-137 458.5 0.3 1.5 2 0 0 2 2 2 1 Peptidase family M3 HECT PF00632.25 CRG84736.1 - 0.064 12.7 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 HECT-domain (ubiquitin-transferase) Imm42 PF15593.6 CRG84736.1 - 0.1 13.0 0.6 2.6 8.5 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 42 DUF3328 PF11807.8 CRG84738.1 - 5e-36 124.5 0.6 5e-36 124.5 0.6 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF3328) DUF3813 PF12758.7 CRG84738.1 - 4.1 7.8 6.5 1.1 9.6 1.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) SAPS PF04499.15 CRG84741.1 - 6.6e-198 658.4 0.4 9.2e-197 654.7 0.0 2.7 3 0 0 3 3 3 1 SIT4 phosphatase-associated protein Snf7 PF03357.21 CRG84742.1 - 1.6e-42 145.1 16.9 1.9e-42 144.8 16.9 1.0 1 0 0 1 1 1 1 Snf7 DUF4201 PF13870.6 CRG84742.1 - 0.002 17.9 7.4 0.002 17.9 7.4 2.0 1 1 2 3 3 3 1 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 CRG84742.1 - 0.014 15.9 6.0 0.68 10.4 1.0 2.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 CRG84742.1 - 0.016 15.3 4.5 4.7 7.4 1.1 3.2 2 1 0 3 3 3 0 bZIP transcription factor Alpha-2-MRAP_C PF06401.11 CRG84742.1 - 0.028 14.4 4.9 0.032 14.2 3.4 1.8 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF848 PF05852.11 CRG84742.1 - 0.028 14.5 5.9 0.044 13.9 5.0 1.8 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Zwint PF15556.6 CRG84742.1 - 0.028 13.9 9.6 0.034 13.6 9.2 1.3 1 1 0 1 1 1 0 ZW10 interactor CLZ PF16526.5 CRG84742.1 - 0.035 14.5 6.2 1.8 8.9 0.1 3.4 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Prefoldin_2 PF01920.20 CRG84742.1 - 0.055 13.4 8.6 0.84 9.6 0.0 3.4 2 1 0 2 2 2 0 Prefoldin subunit HHH_2 PF12826.7 CRG84742.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif FlaC_arch PF05377.11 CRG84742.1 - 0.14 12.5 7.7 11 6.5 0.0 3.4 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) Exonuc_VII_L PF02601.15 CRG84742.1 - 0.19 11.2 3.5 0.24 11.0 3.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCDC-167 PF15188.6 CRG84742.1 - 7 7.1 7.3 3.1 8.2 0.0 3.1 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 Uso1_p115_C PF04871.13 CRG84742.1 - 8.2 6.8 15.2 7.4 7.0 11.0 2.6 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Nramp PF01566.18 CRG84743.1 - 2.4e-90 303.1 18.6 2.4e-90 303.1 18.6 1.4 2 0 0 2 2 2 1 Natural resistance-associated macrophage protein Drf_GBD PF06371.13 CRG84744.1 - 2.3e-15 56.7 1.2 7.5e-14 51.7 1.2 2.5 1 1 0 1 1 1 1 Diaphanous GTPase-binding Domain Thiolase_N PF00108.23 CRG84746.1 - 1.3e-73 247.6 2.6 1.3e-73 247.6 2.6 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG84746.1 - 1.9e-43 147.1 0.2 4.6e-43 145.8 0.2 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CRG84746.1 - 0.028 14.0 0.8 0.16 11.5 0.3 2.2 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain BLM10_mid PF16507.5 CRG84747.1 - 7.3e-215 714.6 0.0 1.3e-214 713.8 0.0 1.4 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 CRG84747.1 - 2.4e-29 101.1 0.0 1.5e-28 98.6 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 CRG84747.1 - 2.6e-20 72.5 0.1 9.8e-20 70.6 0.0 2.0 2 0 0 2 2 2 1 Proteasome-substrate-size regulator, N-terminal CLASP_N PF12348.8 CRG84747.1 - 0.018 14.6 1.6 2.3 7.7 0.0 3.7 3 1 0 3 3 3 0 CLASP N terminal NMN_transporter PF04973.12 CRG84747.1 - 0.066 13.2 0.8 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 Nicotinamide mononucleotide transporter HEAT PF02985.22 CRG84747.1 - 0.15 12.4 0.0 73 4.0 0.0 4.5 5 0 0 5 5 5 0 HEAT repeat FA_hydroxylase PF04116.13 CRG84748.1 - 3.1e-21 76.1 12.4 3.1e-21 76.1 12.4 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Mannosyl_trans2 PF04188.13 CRG84749.1 - 7.1e-49 167.3 14.1 1.8e-48 166.0 13.3 1.9 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) Pro_CA PF00484.19 CRG84750.1 - 1.2e-44 152.4 0.2 1.5e-44 152.0 0.2 1.1 1 0 0 1 1 1 1 Carbonic anhydrase PMG PF05287.12 CRG84750.1 - 0.02 15.0 0.2 0.029 14.4 0.2 1.1 1 0 0 1 1 1 0 PMG protein RCS1 PF07326.11 CRG84750.1 - 0.12 12.3 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Regulator of chromosome segregation 1 PBP1_TM PF14812.6 CRG84751.1 - 0.0096 16.3 0.3 0.0096 16.3 0.3 3.8 4 0 0 4 4 4 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Velvet PF11754.8 CRG84753.1 - 4.9e-47 161.0 9.7 1.5e-31 110.3 0.2 3.2 2 1 1 3 3 3 2 Velvet factor MOZ_SAS PF01853.18 CRG84754.1 - 1e-74 250.1 0.0 1.6e-74 249.4 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CRG84754.1 - 4.7e-21 74.2 3.3 1.1e-20 73.0 3.3 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain PHD_4 PF16866.5 CRG84754.1 - 2.9e-11 43.3 7.7 9.5e-11 41.6 7.7 1.9 1 0 0 1 1 1 1 PHD-finger PHD PF00628.29 CRG84754.1 - 0.0066 16.3 9.3 0.0066 16.3 9.3 2.3 2 0 0 2 2 2 1 PHD-finger Prok-RING_1 PF14446.6 CRG84754.1 - 0.54 10.2 4.1 1.8 8.5 4.1 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-piccolo PF05715.13 CRG84754.1 - 4.3 7.6 6.2 8.8 6.6 6.2 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger MWFE PF15879.5 CRG84755.1 - 7.6e-26 90.0 0.1 9.5e-26 89.7 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit V_ATPase_I PF01496.19 CRG84756.1 - 0 1068.5 0.0 0 1068.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family RraA-like PF03737.15 CRG84756.1 - 4.2e-26 91.9 0.1 6.6e-26 91.3 0.1 1.3 1 0 0 1 1 1 1 Aldolase/RraA CheZ PF04344.13 CRG84756.1 - 0.012 15.6 1.3 0.045 13.7 0.1 2.2 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ DUF3552 PF12072.8 CRG84756.1 - 0.033 13.6 0.6 4.2 6.7 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) Filament PF00038.21 CRG84756.1 - 0.061 12.9 1.5 8 5.9 0.1 2.3 2 0 0 2 2 2 0 Intermediate filament protein CdvA PF18822.1 CRG84756.1 - 0.16 11.8 1.5 26 4.7 0.0 3.4 2 1 1 3 3 3 0 CdvA-like coiled-coil domain Linker_histone PF00538.19 CRG84756.1 - 0.17 12.2 0.1 0.39 11.1 0.1 1.5 1 0 0 1 1 1 0 linker histone H1 and H5 family DUF1515 PF07439.11 CRG84756.1 - 0.19 11.7 0.2 0.54 10.3 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DivIC PF04977.15 CRG84756.1 - 0.27 11.0 1.4 0.63 9.8 0.3 2.3 2 0 0 2 2 2 0 Septum formation initiator DUF1218 PF06749.12 CRG84756.1 - 0.6 10.7 2.9 2 9.0 2.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) PspB PF06667.12 CRG84756.1 - 0.63 10.1 2.3 23 5.1 0.1 3.7 4 0 0 4 4 4 0 Phage shock protein B FBPase PF00316.20 CRG84758.1 - 9.9e-68 227.3 0.1 1.3e-67 227.0 0.1 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 CRG84758.1 - 0.063 12.8 0.0 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 Inositol monophosphatase family Aha1_N PF09229.11 CRG84761.1 - 1.7e-40 138.4 3.1 3.3e-40 137.5 3.1 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 CRG84761.1 - 1e-19 71.0 0.5 2e-19 70.0 0.5 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Sacchrp_dh_C PF16653.5 CRG84762.1 - 4.3e-94 315.5 0.0 7.3e-94 314.8 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 CRG84762.1 - 9.2e-24 84.2 0.6 1.8e-23 83.2 0.6 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CRG84762.1 - 1.9e-05 24.8 0.1 3.6e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 CRG84762.1 - 5.7e-05 23.1 0.5 0.00011 22.2 0.5 1.5 1 0 0 1 1 1 1 NAD(P)H-binding AlaDh_PNT_C PF01262.21 CRG84762.1 - 0.0018 17.6 0.6 0.0027 17.0 0.6 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 CRG84762.1 - 0.0049 17.3 0.2 0.0089 16.5 0.2 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Epimerase PF01370.21 CRG84762.1 - 0.021 14.3 0.1 0.034 13.6 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family IlvN PF07991.12 CRG84762.1 - 0.078 12.5 0.5 0.21 11.2 0.2 1.9 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NmrA PF05368.13 CRG84762.1 - 0.087 12.4 0.3 0.14 11.7 0.3 1.3 1 0 0 1 1 1 0 NmrA-like family Semialdhyde_dh PF01118.24 CRG84762.1 - 0.096 13.1 0.2 0.18 12.2 0.2 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 CRG84762.1 - 0.11 13.2 0.6 0.17 12.6 0.6 1.3 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Prenyltransf PF01255.19 CRG84763.1 - 7.3e-79 264.4 0.0 1.2e-78 263.7 0.0 1.3 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Acyltransferase PF01553.21 CRG84764.1 - 1.6e-09 37.5 0.0 0.00065 19.3 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase PRA-PH PF01503.17 CRG84764.1 - 0.17 12.3 0.0 0.58 10.6 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase DUF4220 PF13968.6 CRG84764.1 - 0.26 10.6 2.7 0.52 9.7 2.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) Vps36_ESCRT-II PF11605.8 CRG84765.1 - 4.3e-05 23.6 0.0 0.0003 20.9 0.0 2.0 1 1 1 2 2 2 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 CRG84765.1 - 0.07 13.0 0.0 0.14 12.1 0.0 1.5 1 1 0 1 1 1 0 GRAM domain UCR_hinge PF02320.16 CRG84766.1 - 3.9e-27 94.2 8.6 3.9e-27 94.2 8.6 1.9 2 1 0 2 2 1 1 Ubiquinol-cytochrome C reductase hinge protein Hamartin PF04388.12 CRG84766.1 - 0.43 9.2 10.1 0.49 9.0 10.1 1.0 1 0 0 1 1 1 0 Hamartin protein DUF4045 PF13254.6 CRG84766.1 - 0.84 9.2 19.3 1 9.0 19.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) BUD22 PF09073.10 CRG84766.1 - 1.1 8.5 23.4 1.3 8.3 23.4 1.1 1 0 0 1 1 1 0 BUD22 VIR_N PF15912.5 CRG84766.1 - 1.5 8.4 17.1 1.8 8.1 17.1 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Mitofilin PF09731.9 CRG84766.1 - 2.1 7.1 21.2 2.5 6.8 21.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SAPS PF04499.15 CRG84766.1 - 2.5 6.8 10.9 2.7 6.7 10.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 CRG84766.1 - 3.5 6.5 8.2 4 6.4 8.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Nop14 PF04147.12 CRG84766.1 - 3.6 5.7 25.2 4 5.5 25.2 1.0 1 0 0 1 1 1 0 Nop14-like family COG4 PF08318.12 CRG84766.1 - 4.5 6.2 8.0 7.9 5.4 8.0 1.5 1 1 0 1 1 1 0 COG4 transport protein SDA1 PF05285.12 CRG84766.1 - 5 6.5 25.7 6.1 6.2 25.7 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CRG84766.1 - 5.2 5.2 16.8 6.1 5.0 16.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 CRG84766.1 - 6.6 5.4 16.7 8.7 5.0 16.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Raftlin PF15250.6 CRG84766.1 - 7.6 5.2 12.8 8.7 5.0 12.8 1.2 1 0 0 1 1 1 0 Raftlin CCSAP PF15748.5 CRG84766.1 - 7.7 6.6 19.1 9.9 6.3 19.1 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Neur_chan_memb PF02932.16 CRG84766.1 - 8.1 6.4 6.9 10 6.1 6.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MFS_1 PF07690.16 CRG84768.1 - 1.2e-25 90.2 34.2 1.2e-25 90.2 34.2 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 CRG84768.1 - 2.4e-07 29.7 1.7 2.4e-07 29.7 1.7 2.4 2 1 1 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 CRG84768.1 - 9.1e-07 28.1 6.8 0.00048 19.1 0.2 3.0 1 1 2 3 3 3 3 MFS_1 like family DUF805 PF05656.14 CRG84768.1 - 0.046 14.1 1.0 0.046 14.1 1.0 2.9 3 2 0 3 3 3 0 Protein of unknown function (DUF805) Uds1 PF15456.6 CRG84769.1 - 3.9e-40 137.0 0.0 3.9e-40 137.0 0.0 5.4 4 2 0 4 4 4 1 Up-regulated During Septation HALZ PF02183.18 CRG84769.1 - 0.052 13.8 0.1 0.052 13.8 0.1 5.3 5 0 0 5 5 5 0 Homeobox associated leucine zipper WD40 PF00400.32 CRG84770.1 - 8.5e-29 99.2 15.6 0.00014 22.6 0.0 7.9 9 0 0 9 9 9 5 WD domain, G-beta repeat F-box-like PF12937.7 CRG84770.1 - 1.7e-11 43.8 0.6 4.3e-11 42.5 0.6 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG84770.1 - 2.7e-07 30.3 0.0 5.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 CRG84770.1 - 0.0017 17.7 0.1 0.14 11.5 0.0 2.5 2 0 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 CRG84770.1 - 0.002 18.4 0.3 0.14 12.5 0.0 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG84770.1 - 0.078 11.6 1.2 8.5 4.9 0.0 2.9 3 0 0 3 3 3 0 Nucleoporin Nup120/160 TFIIA PF03153.13 CRG84770.1 - 4.2 7.3 31.6 9.6 6.1 31.6 1.5 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PH_10 PF15411.6 CRG84771.1 - 9.6e-41 138.9 0.0 1.7e-40 138.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 CRG84771.1 - 5.4e-31 106.7 0.0 1.1e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 CRG84771.1 - 2.7e-24 86.4 2.4 7.8e-24 84.9 1.6 2.1 2 0 0 2 2 2 1 RhoGEF domain PB1 PF00564.24 CRG84771.1 - 2.9e-09 36.7 0.1 7.9e-09 35.3 0.1 1.7 1 0 0 1 1 1 1 PB1 domain YppF PF14178.6 CRG84771.1 - 0.045 13.6 1.4 12 5.9 0.1 3.4 3 0 0 3 3 3 0 YppF-like protein Aminotran_1_2 PF00155.21 CRG84772.1 - 4.7e-32 111.5 0.0 5.2e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Suc_Fer-like PF06999.12 CRG84773.1 - 3.4e-67 226.1 0.0 4.8e-67 225.6 0.0 1.2 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DUF4129 PF13559.6 CRG84773.1 - 0.026 14.8 0.0 0.1 12.9 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) MMtag PF10159.9 CRG84773.1 - 0.085 13.2 0.3 0.18 12.1 0.3 1.4 1 0 0 1 1 1 0 Multiple myeloma tumor-associated zf-C2H2 PF00096.26 CRG84774.1 - 1e-18 66.6 33.9 2.1e-05 24.7 3.4 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG84774.1 - 1.8e-16 59.7 27.5 1.6e-05 25.1 2.1 5.1 4 1 1 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG84774.1 - 1.7e-07 31.5 31.1 0.053 14.4 2.6 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger FOXP-CC PF16159.5 CRG84774.1 - 0.0029 18.2 13.5 0.051 14.2 0.4 3.5 3 1 0 3 3 3 3 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 CRG84774.1 - 0.02 15.2 10.2 2.4 8.5 0.2 3.4 1 1 0 2 2 2 0 C2H2-type zinc ribbon adh_short PF00106.25 CRG84775.1 - 8.1e-10 38.5 0.0 0.00062 19.3 0.1 3.1 2 1 0 2 2 2 2 short chain dehydrogenase DUF2568 PF10823.8 CRG84775.1 - 0.0062 16.8 0.3 0.014 15.7 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2568) adh_short_C2 PF13561.6 CRG84775.1 - 0.007 15.9 0.0 3 7.3 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG84775.1 - 0.039 13.9 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 KR domain NTP_transferase PF00483.23 CRG84777.1 - 4.1e-53 180.5 0.0 8.1e-53 179.5 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 CRG84777.1 - 1e-13 50.4 6.9 3.1e-10 39.4 1.8 3.2 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 CRG84777.1 - 8.1e-10 39.3 0.0 1.2e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 CRG84777.1 - 4e-06 26.5 6.2 7.2e-06 25.7 0.6 3.0 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 CRG84777.1 - 0.029 12.5 0.1 0.044 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) IspD PF01128.19 CRG84777.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase SRP54 PF00448.22 CRG84777.1 - 0.16 11.6 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Syntaxin_2 PF14523.6 CRG84779.1 - 0.74 10.2 3.2 8.7 6.8 0.8 3.2 2 1 0 2 2 2 0 Syntaxin-like protein Plasmid_RAQPRD PF09686.10 CRG84780.1 - 0.076 13.2 2.7 1 9.6 0.2 2.5 1 1 1 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) Fes1 PF08609.10 CRG84780.1 - 0.089 13.7 2.2 0.19 12.6 2.2 1.7 1 1 0 1 1 1 0 Nucleotide exchange factor Fes1 Helicase_C PF00271.31 CRG84781.1 - 1.4e-10 41.5 0.0 3.1e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CRG84781.1 - 1.6e-10 40.2 0.0 2.9e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain GST_C PF00043.25 CRG84785.1 - 3.6e-16 59.2 0.0 5.7e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG84785.1 - 4.8e-10 39.5 0.0 8.3e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG84785.1 - 2.2e-08 34.0 0.0 4.9e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain p450 PF00067.22 CRG84785.1 - 0.00049 19.0 0.0 0.00074 18.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 GST_N_2 PF13409.6 CRG84785.1 - 0.061 13.6 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GMC_oxred_N PF00732.19 CRG84786.1 - 1.2e-58 198.9 0.9 1.6e-58 198.5 0.9 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG84786.1 - 1.6e-27 96.8 0.0 2.9e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Thi4 PF01946.17 CRG84786.1 - 6.6e-06 25.5 0.1 1.3e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CRG84786.1 - 2.1e-05 23.8 0.1 0.00012 21.2 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CRG84786.1 - 0.00023 21.3 0.1 0.00084 19.5 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG84786.1 - 0.00028 20.6 1.1 0.0027 17.3 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG84786.1 - 0.00028 20.3 0.7 0.14 11.4 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG84786.1 - 0.00039 19.2 0.8 0.06 12.0 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 CRG84786.1 - 0.00075 18.7 0.8 0.0081 15.3 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG84786.1 - 0.021 14.1 1.4 0.03 13.6 0.3 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CRG84786.1 - 0.031 14.5 0.2 0.06 13.6 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_9 PF13454.6 CRG84786.1 - 0.037 14.0 0.1 0.097 12.6 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 CRG84786.1 - 0.042 14.4 0.1 0.25 11.9 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DUF4267 PF14087.6 CRG84787.1 - 1.6e-19 70.0 0.5 4.5e-19 68.6 0.4 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4267) DUF4345 PF14248.6 CRG84787.1 - 0.014 15.3 0.9 0.031 14.2 0.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4345) Pet20 PF08692.10 CRG84788.1 - 0.17 12.6 0.0 31 5.3 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Peptidase_M41 PF01434.18 CRG84789.1 - 2.8e-58 196.9 0.5 5.4e-58 196.0 0.5 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CRG84789.1 - 6.1e-43 146.4 0.0 2.2e-42 144.6 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG84789.1 - 1.7e-10 40.5 0.0 6.2e-10 38.7 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 CRG84789.1 - 2.7e-05 24.2 0.0 9.2e-05 22.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CRG84789.1 - 5.1e-05 22.6 0.4 0.00013 21.3 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 CRG84789.1 - 5.8e-05 23.4 1.0 0.057 13.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CRG84789.1 - 6.1e-05 23.5 3.0 0.00028 21.3 0.6 3.0 3 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 CRG84789.1 - 0.00038 20.2 0.0 0.0013 18.5 0.0 2.0 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CRG84789.1 - 0.0029 17.8 0.0 0.012 15.8 0.0 2.2 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CRG84789.1 - 0.0084 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 CRG84789.1 - 0.011 14.9 0.0 0.026 13.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_18 PF13238.6 CRG84789.1 - 0.017 15.6 0.0 0.063 13.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 CRG84789.1 - 0.019 15.1 0.2 0.075 13.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 CRG84789.1 - 0.024 14.0 0.3 0.049 13.0 0.3 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CRG84789.1 - 0.033 13.7 1.6 0.8 9.2 0.3 2.6 1 1 0 2 2 2 0 AAA domain ATPase PF06745.13 CRG84789.1 - 0.049 13.0 1.5 1.2 8.4 0.0 2.9 3 0 0 3 3 3 0 KaiC NACHT PF05729.12 CRG84789.1 - 0.054 13.4 0.4 1.7 8.5 0.1 2.6 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 CRG84789.1 - 0.054 13.9 0.2 0.23 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CRG84789.1 - 0.065 13.5 0.2 0.19 11.9 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_14 PF13173.6 CRG84789.1 - 0.12 12.4 0.0 0.38 10.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 CRG84789.1 - 0.17 11.4 0.1 0.49 9.9 0.1 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region FGGY_C PF02782.16 CRG84790.1 - 6.9e-74 247.9 0.7 1.1e-73 247.2 0.7 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CRG84790.1 - 6e-62 209.4 0.0 8.1e-62 209.0 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CRG84790.1 - 0.052 13.0 0.6 1.9 7.9 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family AA_permease PF00324.21 CRG84791.1 - 1.1e-41 143.0 31.9 2e-41 142.1 31.9 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG84791.1 - 1.9e-19 69.8 34.1 5.6e-19 68.3 34.1 1.8 1 1 0 1 1 1 1 Amino acid permease CorA PF01544.18 CRG84792.1 - 1.2e-13 51.1 1.5 1.8e-13 50.5 1.5 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PMT_4TMC PF16192.5 CRG84792.1 - 0.0013 18.4 4.1 0.89 9.1 1.9 2.8 2 1 0 2 2 2 2 C-terminal four TMM region of protein-O-mannosyltransferase Virul_fac_BrkB PF03631.15 CRG84792.1 - 0.0077 15.9 1.4 0.014 15.0 1.4 1.4 1 0 0 1 1 1 1 Virulence factor BrkB Lig_chan PF00060.26 CRG84792.1 - 0.027 14.3 1.1 0.082 12.7 1.1 1.8 1 0 0 1 1 1 0 Ligand-gated ion channel LPG_synthase_TM PF03706.13 CRG84792.1 - 0.038 13.5 0.2 0.07 12.6 0.2 1.4 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region Orf78 PF06024.12 CRG84792.1 - 0.17 12.2 1.2 0.64 10.3 0.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Pkinase PF00069.25 CRG84793.1 - 8.9e-20 71.1 0.7 3e-19 69.4 0.7 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84793.1 - 1.4e-15 57.3 0.0 5.5e-13 48.8 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 CRG84793.1 - 0.075 12.0 0.2 0.13 11.2 0.2 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3429 PF11911.8 CRG84795.1 - 8.6e-43 146.1 11.0 1.4e-42 145.4 11.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) SHR-BD PF06650.12 CRG84796.1 - 4.7e-98 327.9 1.2 1e-96 323.5 0.0 3.4 4 1 0 4 4 4 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 CRG84796.1 - 2.8e-91 305.1 19.0 5e-89 297.8 1.9 5.9 6 0 0 6 6 6 2 Repeating coiled region of VPS13 VPS13 PF16908.5 CRG84796.1 - 4.6e-81 272.1 0.1 6.9e-79 265.0 0.0 3.8 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_C PF16909.5 CRG84796.1 - 1.1e-71 240.3 3.3 9.1e-69 230.8 0.1 2.6 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 CRG84796.1 - 1e-40 138.5 0.0 2.9e-40 137.0 0.0 1.9 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 CRG84796.1 - 8.1e-07 29.3 0.2 4.5e-06 26.9 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain PemK_toxin PF02452.17 CRG84796.1 - 0.003 18.0 0.2 0.018 15.4 0.1 2.4 2 0 0 2 2 2 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system DUF896 PF05979.12 CRG84796.1 - 0.043 13.7 6.2 0.38 10.6 0.3 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) GCFC PF07842.12 CRG84797.1 - 9.2e-85 284.6 5.2 9.2e-85 284.6 5.2 1.7 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 CRG84797.1 - 1.8e-15 56.5 0.9 4.1e-15 55.4 0.9 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 CRG84797.1 - 9.6e-09 35.2 0.2 3e-08 33.6 0.2 1.9 1 0 0 1 1 1 1 G-patch domain DUF5344 PF17279.2 CRG84797.1 - 0.15 12.6 1.2 0.37 11.4 1.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5344) DUF4100 PF13352.6 CRG84797.1 - 1.1 9.0 5.7 1.7 8.4 5.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4100) Sod_Fe_C PF02777.18 CRG84798.1 - 1e-36 125.2 0.6 1.9e-36 124.3 0.6 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CRG84798.1 - 6.5e-28 97.0 1.2 1.1e-27 96.3 1.2 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Cnn_1N PF07989.11 CRG84799.1 - 4.7e-08 33.1 9.3 1.2e-07 31.7 9.3 1.8 1 0 0 1 1 1 1 Centrosomin N-terminal motif 1 MAD PF05557.13 CRG84799.1 - 0.00015 20.4 6.9 0.0002 19.9 6.9 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein AAA_23 PF13476.6 CRG84799.1 - 0.0012 19.4 4.5 0.0021 18.6 4.5 1.4 1 0 0 1 1 1 1 AAA domain Prominin PF05478.11 CRG84799.1 - 0.017 13.1 2.3 0.024 12.6 2.3 1.2 1 0 0 1 1 1 0 Prominin EzrA PF06160.12 CRG84799.1 - 0.053 11.7 6.7 0.089 11.0 6.7 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF724 PF05266.14 CRG84799.1 - 0.13 12.1 5.8 0.29 10.9 5.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.11 CRG84799.1 - 0.27 10.1 8.2 0.45 9.3 8.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 CRG84799.1 - 0.65 10.5 16.4 2.1 8.9 16.4 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region PCRF PF03462.18 CRG84799.1 - 1.2 9.0 6.1 2.5 7.9 6.1 1.5 1 0 0 1 1 1 0 PCRF domain Uso1_p115_C PF04871.13 CRG84799.1 - 1.3 9.4 12.8 4 7.8 12.8 1.8 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region BRE1 PF08647.11 CRG84799.1 - 2.4 8.3 12.3 4.9 7.3 12.3 1.5 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 CRG84799.1 - 2.8 8.6 6.6 8.7 7.0 6.6 1.8 1 0 0 1 1 1 0 Initiation control protein YabA ZapB PF06005.12 CRG84799.1 - 3 8.3 15.3 17 5.9 0.1 2.5 1 1 1 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 CRG84799.1 - 5.4 7.1 7.6 2.9 8.0 3.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 CRG84799.1 - 7.7 7.3 8.2 7.3 7.3 5.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Sld5 PF05916.11 CRG84800.1 - 4e-22 78.8 0.0 5.2e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein DUF775 PF05603.12 CRG84801.1 - 0.25 10.8 0.8 0.66 9.5 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Aldo_ket_red PF00248.21 CRG84802.1 - 7.6e-68 228.8 0.0 8.7e-68 228.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3580 PF12117.8 CRG84802.1 - 0.023 14.9 0.0 0.085 13.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3580) LD_cluster3 PF18180.1 CRG84802.1 - 0.17 11.5 0.0 0.28 10.8 0.0 1.3 1 0 0 1 1 1 0 SLOG cluster3 family Transket_pyr PF02779.24 CRG84804.1 - 1.6e-64 216.9 0.0 2.5e-64 216.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 CRG84804.1 - 2e-59 201.0 0.0 3e-59 200.4 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 CRG84804.1 - 5.7e-57 191.7 0.1 1.3e-56 190.6 0.0 1.6 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 CRG84804.1 - 1.7e-19 69.1 0.9 1.7e-19 69.1 0.9 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus ING PF12998.7 CRG84805.1 - 2.8e-11 43.9 0.0 6.4e-11 42.7 0.0 1.6 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CRG84805.1 - 8.2e-06 25.6 7.7 1.4e-05 24.9 7.7 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CRG84805.1 - 0.055 13.7 1.6 0.12 12.7 1.6 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 CRG84805.1 - 0.082 12.5 1.6 0.15 11.6 1.6 1.5 1 0 0 1 1 1 0 PHD-finger LRR_4 PF12799.7 CRG84806.1 - 4e-09 36.6 10.2 0.0008 19.8 0.3 5.9 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CRG84806.1 - 1.8e-07 30.9 0.1 6.1e-07 29.2 0.1 2.0 1 0 0 1 1 1 1 F-box-like LRR_6 PF13516.6 CRG84806.1 - 0.00015 21.5 5.6 7.2 6.9 0.2 6.1 5 0 0 5 5 5 1 Leucine Rich repeat LRR_8 PF13855.6 CRG84806.1 - 0.00031 20.4 10.1 0.0083 15.9 2.6 4.6 4 1 1 5 5 5 1 Leucine rich repeat F-box PF00646.33 CRG84806.1 - 0.19 11.7 5.1 0.59 10.1 1.6 3.6 3 1 0 3 3 3 0 F-box domain LRR_1 PF00560.33 CRG84806.1 - 0.5 11.1 17.9 16 6.5 0.1 7.0 8 0 0 8 8 8 0 Leucine Rich Repeat Cyt_bd_oxida_I PF01654.17 CRG84806.1 - 0.79 8.3 2.4 1.2 7.7 2.4 1.1 1 0 0 1 1 1 0 Cytochrome bd terminal oxidase subunit I BSD PF03909.17 CRG84808.1 - 8.2e-30 102.6 9.3 5.4e-15 55.1 0.9 3.1 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 CRG84808.1 - 2.8e-26 91.7 0.6 4.8e-26 90.9 0.1 1.7 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain Rx_N PF18052.1 CRG84808.1 - 0.12 12.7 0.1 0.32 11.3 0.1 1.7 1 0 0 1 1 1 0 Rx N-terminal domain DUF1751 PF08551.10 CRG84809.1 - 0.011 16.2 0.3 0.011 16.2 0.3 1.8 2 0 0 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) ANAPC_CDC26 PF10471.9 CRG84809.1 - 5.1 8.0 7.6 7.2 7.5 2.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 adh_short_C2 PF13561.6 CRG84810.1 - 5.6e-60 202.8 0.0 7.3e-60 202.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG84810.1 - 4.4e-47 160.1 0.1 5.7e-47 159.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG84810.1 - 1.5e-08 34.8 0.2 3.2e-08 33.7 0.2 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG84810.1 - 0.003 17.1 0.1 0.0062 16.0 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CRG84810.1 - 0.0033 17.7 0.0 0.0051 17.1 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 CRG84810.1 - 0.016 15.1 0.1 0.022 14.6 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Glyco_hydro_127 PF07944.12 CRG84815.1 - 2.1e-115 386.2 0.0 2.5e-115 385.9 0.0 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Fungal_trans PF04082.18 CRG84816.1 - 1.5e-11 43.8 0.7 2.9e-11 42.9 0.2 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF722 PF05263.11 CRG84816.1 - 0.26 11.5 0.7 0.88 9.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF722) Hydrolase_6 PF13344.6 CRG84817.1 - 4.7e-23 81.2 0.0 8.1e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG84817.1 - 7.1e-19 67.6 0.0 1.8e-18 66.3 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 CRG84817.1 - 0.012 15.8 0.0 0.21 11.7 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG84817.1 - 0.025 14.9 0.0 1.4 9.2 0.0 2.5 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase 5-nucleotidase PF06189.12 CRG84817.1 - 0.11 11.4 0.1 0.17 10.7 0.1 1.2 1 0 0 1 1 1 0 5'-nucleotidase Aldo_ket_red PF00248.21 CRG84818.1 - 1.8e-50 171.8 0.0 5.1e-50 170.3 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family DJ-1_PfpI PF01965.24 CRG84819.1 - 4.9e-12 46.0 0.0 1.3e-11 44.6 0.0 1.7 1 1 1 2 2 2 1 DJ-1/PfpI family ThiJ_like PF17124.5 CRG84819.1 - 0.056 13.1 0.0 0.076 12.7 0.0 1.3 1 0 0 1 1 1 0 ThiJ/PfpI family-like BacteriocIIc_cy PF12173.8 CRG84819.1 - 0.096 13.0 0.2 23 5.3 0.1 2.4 2 0 0 2 2 2 0 Bacteriocin class IIc cyclic gassericin A-like SUZ PF12752.7 CRG84821.1 - 0.00013 22.7 8.1 0.00013 22.7 8.1 4.8 3 2 0 3 3 3 1 SUZ domain Hexapep PF00132.24 CRG84822.1 - 5.6e-11 41.7 14.2 8e-10 38.1 4.4 2.8 3 0 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG84822.1 - 2.8e-09 36.5 7.6 5.6e-08 32.4 3.7 2.7 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Mac PF12464.8 CRG84822.1 - 0.00013 22.2 0.0 0.00024 21.2 0.0 1.5 1 0 0 1 1 1 1 Maltose acetyltransferase GST_C_5 PF16865.5 CRG84822.1 - 0.0017 18.9 0.0 0.004 17.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG84822.1 - 0.0022 18.0 0.0 0.0049 16.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ATP_bind_1 PF03029.17 CRG84823.1 - 3.5e-70 236.5 0.0 4.7e-70 236.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 CRG84823.1 - 0.00021 20.9 0.0 0.0041 16.7 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 CRG84823.1 - 0.0025 16.8 0.0 0.08 11.9 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 CRG84823.1 - 0.038 13.5 0.0 0.082 12.4 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B Methyltransf_32 PF13679.6 CRG84823.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PRK PF00485.18 CRG84823.1 - 0.062 13.0 0.0 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family CLP1_P PF16575.5 CRG84823.1 - 0.14 11.9 0.0 0.48 10.2 0.0 1.8 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NACHT PF05729.12 CRG84823.1 - 0.19 11.6 0.0 0.42 10.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain CwfJ_C_2 PF04676.14 CRG84824.1 - 2.3e-30 105.4 0.1 1e-29 103.3 0.1 2.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 CRG84824.1 - 3.6e-30 104.3 0.0 1.9e-29 102.0 0.0 2.0 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 FumaraseC_C PF10415.9 CRG84824.1 - 0.062 13.7 0.2 11 6.5 0.1 2.9 2 0 0 2 2 2 0 Fumarase C C-terminus 2-Hacid_dh_C PF02826.19 CRG84825.1 - 2.3e-58 196.5 0.0 3.3e-58 196.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG84825.1 - 1.4e-14 53.9 0.0 2e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG84825.1 - 9.8e-06 25.8 0.0 1.6e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CRG84825.1 - 0.0029 17.2 0.0 0.0053 16.3 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 CRG84825.1 - 0.13 12.8 0.0 0.25 12.0 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 CRG84825.1 - 0.14 12.2 0.1 0.42 10.7 0.0 1.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Zn_clus PF00172.18 CRG84826.1 - 1.4e-08 34.7 8.7 2.2e-08 34.1 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CAP_GLY PF01302.25 CRG84828.1 - 6.5e-20 70.9 0.1 1.7e-19 69.6 0.1 1.7 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 CRG84828.1 - 3.7e-11 43.1 20.2 0.0053 17.2 0.0 5.9 5 1 3 8 8 8 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 CRG84828.1 - 4.5e-09 36.1 6.6 0.0093 15.5 0.5 4.1 1 1 3 4 4 4 3 Leucine-rich repeat zf-U1 PF06220.12 CRG84828.1 - 3.4e-06 26.7 0.1 7.5e-06 25.6 0.1 1.6 1 0 0 1 1 1 1 U1 zinc finger LRR_8 PF13855.6 CRG84828.1 - 2.4e-05 24.0 21.4 0.019 14.7 4.5 5.2 4 2 2 6 6 6 4 Leucine rich repeat LRR_6 PF13516.6 CRG84828.1 - 0.00026 20.8 10.9 1.6 8.9 0.1 6.8 7 0 0 7 7 7 2 Leucine Rich repeat ABC_tran_Xtn PF12848.7 CRG84828.1 - 3.6 7.7 10.2 0.14 12.3 3.1 2.4 2 1 0 2 2 2 0 ABC transporter LRR_1 PF00560.33 CRG84828.1 - 4.5 8.2 17.9 22 6.1 0.4 6.8 7 1 1 8 8 8 0 Leucine Rich Repeat SF3A2 PF16835.5 CRG84829.1 - 5e-36 123.0 0.1 7.6e-36 122.4 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 CRG84829.1 - 1.1e-05 25.7 0.5 2e-05 24.8 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type PRP4 PF08799.11 CRG84829.1 - 0.045 13.3 1.5 0.11 12.1 1.5 1.7 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like Pkinase PF00069.25 CRG84830.1 - 1.4e-55 188.5 0.3 9.1e-54 182.6 0.0 2.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG84830.1 - 4.6e-24 85.1 2.8 7.6e-19 68.0 0.1 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG84830.1 - 2.8e-06 26.6 0.1 3.8e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CRG84830.1 - 0.00049 19.5 0.5 0.0028 17.1 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG84830.1 - 0.00072 19.5 1.4 0.029 14.3 0.1 2.6 2 1 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 CRG84830.1 - 0.0013 18.1 0.5 0.0026 17.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 CRG84830.1 - 0.025 13.6 0.0 0.039 13.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 CRG84830.1 - 0.035 12.9 0.0 0.061 12.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 CRG84830.1 - 0.076 12.0 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_C PF00433.24 CRG84830.1 - 0.11 13.3 0.0 0.32 11.7 0.0 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain NFACT-C PF11923.8 CRG84830.1 - 0.19 11.6 0.2 0.41 10.6 0.2 1.5 1 0 0 1 1 1 0 NFACT protein C-terminal domain RIO1 PF01163.22 CRG84830.1 - 0.21 11.2 2.0 0.87 9.2 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Tim54 PF11711.8 CRG84831.1 - 6.4e-148 492.5 0.3 7.9e-148 492.2 0.3 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF3438 PF11920.8 CRG84831.1 - 0.039 13.2 0.7 0.085 12.1 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) NARP1 PF12569.8 CRG84832.1 - 5.4e-216 718.5 19.7 2.7e-213 709.5 15.9 2.4 3 0 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 CRG84832.1 - 1.1e-20 73.9 21.5 0.00045 20.7 0.3 7.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 CRG84832.1 - 5.7e-17 60.4 37.1 0.001 19.0 0.2 11.6 12 0 0 12 12 11 5 Tetratricopeptide repeat TPR_14 PF13428.6 CRG84832.1 - 2.6e-15 55.8 19.6 0.095 13.6 0.1 10.8 7 3 4 11 11 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 CRG84832.1 - 1.2e-12 47.8 8.0 0.00094 19.3 0.1 6.0 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG84832.1 - 8.2e-12 44.6 5.3 1.7e-05 24.4 0.2 5.7 5 0 0 5 5 4 2 TPR repeat TPR_16 PF13432.6 CRG84832.1 - 1.2e-11 45.1 23.4 0.072 13.7 0.6 8.9 7 1 3 10 10 8 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG84832.1 - 2.5e-10 40.4 14.5 3.3e-05 24.0 0.9 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CRG84832.1 - 1.5e-06 27.8 37.0 1.7e-05 24.4 0.6 10.1 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG84832.1 - 8.9e-06 25.9 31.8 0.17 12.2 2.3 8.2 7 2 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG84832.1 - 1.3e-05 25.1 28.7 0.00063 19.8 0.1 8.3 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG84832.1 - 0.00015 21.9 9.5 8.1 7.1 0.0 6.6 8 0 0 8 8 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG84832.1 - 0.00026 20.5 6.8 0.48 9.7 0.4 3.7 2 2 1 3 3 3 2 MalT-like TPR region TPR_4 PF07721.14 CRG84832.1 - 0.0066 17.0 7.1 1.7 9.5 0.1 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CRG84832.1 - 0.0076 16.3 3.0 1.6 8.9 0.1 4.1 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.9 CRG84832.1 - 0.0083 15.9 0.1 0.0083 15.9 0.1 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 CRG84832.1 - 0.043 14.5 18.7 1.2 9.9 0.2 7.5 9 0 0 9 9 6 0 Tetratricopeptide repeat RPN7 PF10602.9 CRG84832.1 - 1.1 9.0 12.6 0.74 9.5 0.4 4.3 4 1 0 4 4 4 0 26S proteasome subunit RPN7 Alkyl_sulf_dimr PF14863.6 CRG84832.1 - 1.2 9.6 10.8 1.8 9.0 0.1 4.0 5 0 0 5 5 5 0 Alkyl sulfatase dimerisation TPR_7 PF13176.6 CRG84832.1 - 3 8.1 16.3 5.8 7.2 0.0 7.1 8 0 0 8 8 7 0 Tetratricopeptide repeat Cid2 PF09774.9 CRG84833.1 - 6e-54 182.8 3.5 7e-54 182.6 3.5 1.0 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Fapy_DNA_glyco PF01149.24 CRG84834.1 - 2e-33 115.4 0.0 3.8e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 CRG84834.1 - 1.1e-22 79.8 0.0 2.1e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 CRG84834.1 - 0.009 14.8 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) FAD_binding_4 PF01565.23 CRG84835.1 - 1.2e-22 80.1 2.7 1.2e-22 80.1 2.7 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CRG84835.1 - 5.3e-13 48.8 0.1 1e-12 48.0 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like AAA-ATPase_like PF09820.9 CRG84835.1 - 0.15 11.5 0.2 0.22 10.9 0.2 1.2 1 0 0 1 1 1 0 Predicted AAA-ATPase Cytokin-bind PF09265.10 CRG84835.1 - 0.19 11.1 0.0 0.32 10.3 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding adh_short PF00106.25 CRG84836.1 - 5.6e-25 87.9 1.5 7.2e-25 87.6 1.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG84836.1 - 6.3e-19 68.5 2.2 2.5e-18 66.5 2.2 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sacchrp_dh_NADP PF03435.18 CRG84836.1 - 2e-05 24.8 0.2 3.3e-05 24.1 0.2 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 CRG84836.1 - 6e-05 23.0 2.9 0.0001 22.3 0.3 2.3 1 1 1 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 CRG84836.1 - 0.00042 19.5 0.1 0.00049 19.3 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 CRG84836.1 - 0.0038 17.3 0.0 0.0068 16.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Epimerase PF01370.21 CRG84836.1 - 0.0068 15.9 0.3 0.054 12.9 0.3 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 CRG84836.1 - 0.0077 15.6 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 CRG84836.1 - 0.14 11.5 2.5 0.2 10.9 0.9 2.1 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FAD_binding_4 PF01565.23 CRG84838.1 - 4.2e-23 81.6 1.2 7.9e-23 80.7 1.2 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG84838.1 - 3.6e-11 43.0 2.0 7e-11 42.1 2.0 1.5 1 0 0 1 1 1 1 Berberine and berberine like UbiA PF01040.18 CRG84839.1 - 1.4e-20 73.7 12.5 1.9e-20 73.2 12.5 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family p450 PF00067.22 CRG84840.1 - 1.8e-44 152.3 0.0 2.6e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 EthD PF07110.11 CRG84842.1 - 1.4e-10 42.2 0.0 1.7e-10 41.9 0.0 1.2 1 0 0 1 1 1 1 EthD domain Glyco_hydro_18 PF00704.28 CRG84843.1 - 4.7e-74 249.9 10.5 4.7e-74 249.9 10.5 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 p450 PF00067.22 CRG84843.1 - 4e-44 151.1 0.0 3.5e-32 111.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 Rgp1 PF08737.10 CRG84844.1 - 0.029 13.5 0.1 0.04 13.1 0.1 1.2 1 0 0 1 1 1 0 Rgp1 Epimerase PF01370.21 CRG84846.1 - 3.4e-15 56.2 0.0 6.5e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG84846.1 - 4e-08 33.4 0.0 7.3e-08 32.5 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG84846.1 - 1.7e-07 31.0 0.0 3e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG84846.1 - 0.0002 20.6 0.1 0.00032 19.9 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 CRG84846.1 - 0.00053 19.1 0.0 0.001 18.1 0.0 1.3 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG84846.1 - 0.0013 17.9 0.0 0.031 13.5 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 CRG84846.1 - 0.0024 17.4 0.2 0.0037 16.7 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 CRG84846.1 - 0.014 15.0 0.6 0.023 14.2 0.6 1.4 1 0 0 1 1 1 0 NmrA-like family KR PF08659.10 CRG84846.1 - 0.058 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 KR domain DUF2099 PF09872.9 CRG84846.1 - 0.088 12.0 0.3 0.13 11.4 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2099) Fungal_trans PF04082.18 CRG84847.1 - 3.5e-12 45.9 0.2 5.3e-12 45.3 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain GFO_IDH_MocA PF01408.22 CRG84848.1 - 2.6e-20 73.4 0.0 4.4e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG84848.1 - 0.0016 19.0 0.1 0.0029 18.3 0.1 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 CRG84848.1 - 0.012 15.7 0.0 0.026 14.5 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain Fe_hyd_lg_C PF02906.14 CRG84851.1 - 1.6e-51 175.4 0.0 3.5e-51 174.2 0.0 1.6 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Glycos_transf_3 PF00591.21 CRG84852.1 - 5.5e-55 186.7 0.0 6.1e-46 157.1 0.0 2.2 1 1 1 2 2 2 2 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 CRG84852.1 - 9.2e-06 25.4 0.3 2e-05 24.3 0.3 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain CENP-B_dimeris PF09026.10 CRG84852.1 - 0.33 11.4 5.1 0.84 10.1 5.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ribosomal_L10 PF00466.20 CRG84853.1 - 0.013 15.6 0.0 0.079 13.1 0.0 2.1 2 1 0 2 2 2 0 Ribosomal protein L10 PI-PLC-X PF00388.19 CRG84854.1 - 1.2e-09 37.9 0.0 2.3e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain 2-oxoacid_dh PF00198.23 CRG84855.1 - 5.5e-80 268.2 0.2 8.7e-80 267.5 0.2 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CRG84855.1 - 3.9e-14 52.2 0.0 7.4e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 CRG84855.1 - 9.6e-14 51.4 0.1 3.2e-13 49.8 0.1 1.9 2 0 0 2 2 2 1 e3 binding domain AAA_33 PF13671.6 CRG84856.1 - 3.1e-11 43.6 0.0 1.4e-10 41.5 0.0 1.8 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 CRG84856.1 - 1.4e-10 41.8 0.0 6.3e-09 36.5 0.0 2.8 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 CRG84856.1 - 1.9e-07 31.6 0.4 6.2e-06 26.7 0.1 2.8 1 1 1 2 2 2 1 AAA domain SKI PF01202.22 CRG84856.1 - 2.1e-06 28.0 0.0 9e-06 25.9 0.0 1.9 1 1 0 1 1 1 1 Shikimate kinase dNK PF01712.19 CRG84856.1 - 0.00022 21.1 0.0 0.24 11.2 0.0 2.3 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_22 PF13401.6 CRG84856.1 - 0.00067 19.9 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 CRG84856.1 - 0.0011 18.7 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 Cytidylate kinase AAA_16 PF13191.6 CRG84856.1 - 0.0016 18.8 0.0 0.0034 17.8 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CRG84856.1 - 0.0053 17.2 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CRG84856.1 - 0.0079 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Rad17 PF03215.15 CRG84856.1 - 0.0086 16.0 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_28 PF13521.6 CRG84856.1 - 0.0096 16.2 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK PF00406.22 CRG84856.1 - 0.01 16.0 0.1 0.087 12.9 0.1 2.1 1 1 0 1 1 1 0 Adenylate kinase NTPase_1 PF03266.15 CRG84856.1 - 0.013 15.4 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 CRG84856.1 - 0.019 14.7 0.1 0.032 13.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain Cytidylate_kin2 PF13189.6 CRG84856.1 - 0.022 14.9 0.1 0.11 12.7 0.1 2.3 1 1 0 1 1 1 0 Cytidylate kinase-like family CoaE PF01121.20 CRG84856.1 - 0.025 14.3 0.0 0.055 13.1 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase T2SSE PF00437.20 CRG84856.1 - 0.025 13.6 0.0 0.041 12.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein APS_kinase PF01583.20 CRG84856.1 - 0.031 14.2 0.0 0.079 12.9 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Mg_chelatase PF01078.21 CRG84856.1 - 0.038 13.4 0.0 0.067 12.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 CRG84856.1 - 0.038 13.2 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 CRG84856.1 - 0.042 14.3 0.0 0.074 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CRG84856.1 - 0.055 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CRG84856.1 - 0.058 12.7 0.0 0.13 11.5 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 CRG84856.1 - 0.066 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase PRK PF00485.18 CRG84856.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_5 PF07728.14 CRG84856.1 - 0.079 13.0 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CRG84856.1 - 0.091 12.3 0.0 0.65 9.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CRG84856.1 - 0.094 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CRG84856.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CRG84856.1 - 0.11 12.5 0.0 0.37 10.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CRG84856.1 - 0.12 12.7 0.1 0.26 11.6 0.1 1.6 1 0 0 1 1 1 0 AAA domain Thermopsin PF05317.11 CRG84856.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Thermopsin NB-ARC PF00931.22 CRG84856.1 - 0.15 11.2 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Thymidylate_kin PF02223.17 CRG84856.1 - 0.16 11.7 0.1 3.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase cobW PF02492.19 CRG84856.1 - 0.16 11.6 0.1 0.27 10.8 0.1 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 CRG84856.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Vps26 PF03643.15 CRG84858.1 - 2.4e-129 430.2 0.2 3.2e-129 429.8 0.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 CRG84858.1 - 0.00016 21.7 0.1 0.92 9.6 0.0 3.3 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain DCB PF16213.5 CRG84860.1 - 3.8e-40 137.4 5.0 1.2e-39 135.8 5.0 2.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 CRG84860.1 - 1.1e-38 132.7 0.3 1.1e-38 132.7 0.3 3.7 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 CRG84860.1 - 8.3e-23 80.5 4.6 5.3e-22 77.8 1.2 2.8 3 0 0 3 3 3 2 C-terminal region of Mon2 protein DUF1981 PF09324.10 CRG84860.1 - 0.0004 20.2 0.2 0.27 11.1 0.0 5.3 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) Ipi1_N PF12333.8 CRG84860.1 - 0.022 15.3 0.8 4.8 7.8 0.1 3.8 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation UQ_con PF00179.26 CRG84861.1 - 3.8e-13 49.3 0.0 3.1e-12 46.3 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.22 CRG84861.1 - 0.00027 21.2 0.4 0.38 11.0 0.0 2.9 1 1 0 2 2 2 2 RWD domain RWD PF05773.22 CRG84863.1 - 2.6e-24 85.7 2.5 2.6e-24 85.7 2.5 1.6 2 0 0 2 2 2 1 RWD domain FG-GAP PF01839.23 CRG84863.1 - 0.032 14.3 0.8 0.059 13.5 0.8 1.4 1 0 0 1 1 1 0 FG-GAP repeat DFRP_C PF16543.5 CRG84863.1 - 0.24 11.9 18.3 0.44 11.1 17.0 2.1 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Zip PF02535.22 CRG84863.1 - 0.47 9.6 1.0 0.56 9.4 1.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mit_KHE1 PF10173.9 CRG84863.1 - 4.8 7.2 5.4 8.5 6.4 5.4 1.4 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related TPR_12 PF13424.6 CRG84864.1 - 4.6e-13 49.2 0.5 4.1e-08 33.4 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG84864.1 - 1.9e-11 44.3 2.1 6.8e-05 23.3 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 CRG84864.1 - 3.2e-11 43.7 0.3 7.8e-06 26.4 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 CRG84864.1 - 3.7e-09 36.1 0.3 3.2e-05 23.8 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG84864.1 - 5.9e-08 32.9 3.0 2.9 9.0 0.3 5.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CRG84864.1 - 4.2e-07 29.6 1.1 0.0088 16.1 0.0 4.9 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 CRG84864.1 - 7.2e-07 29.3 5.7 0.0012 19.0 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG84864.1 - 1.3e-06 28.1 0.8 6.3e-05 22.5 0.0 2.6 2 1 1 3 3 2 1 MalT-like TPR region TPR_1 PF00515.28 CRG84864.1 - 1.4e-05 24.7 0.1 0.049 13.5 0.0 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG84864.1 - 4.6e-05 23.5 0.1 15 6.2 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG84864.1 - 6.8e-05 23.0 0.0 0.86 9.9 0.0 3.6 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CRG84864.1 - 0.00076 19.1 0.0 0.0068 16.1 0.0 2.6 3 0 0 3 3 3 1 TPR repeat TPR_6 PF13174.6 CRG84864.1 - 0.0012 19.3 2.1 11 6.9 0.0 5.0 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CRG84864.1 - 0.0022 17.9 0.2 5.5 7.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CRG84864.1 - 0.0024 17.7 3.1 3.3 7.7 0.1 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 CRG84864.1 - 0.039 13.7 0.0 0.23 11.1 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TFIIA PF03153.13 CRG84864.1 - 0.39 10.7 6.4 0.59 10.1 6.4 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_4 PF07721.14 CRG84864.1 - 4.2 8.3 9.2 17 6.4 0.0 3.4 4 0 0 4 4 2 0 Tetratricopeptide repeat SIR2 PF02146.17 CRG84866.1 - 4.2e-59 199.4 0.0 8.2e-59 198.5 0.0 1.5 1 0 0 1 1 1 1 Sir2 family UPF0020 PF01170.18 CRG84866.1 - 2.1e-07 30.8 0.3 8.4e-05 22.3 0.3 2.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 DUF592 PF04574.13 CRG84866.1 - 0.0015 18.3 0.0 0.0039 17.0 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 CRG84866.1 - 0.021 14.6 0.0 3.4 7.4 0.0 2.5 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain N6_N4_Mtase PF01555.18 CRG84866.1 - 0.051 13.3 0.0 0.39 10.4 0.0 2.4 3 0 0 3 3 3 0 DNA methylase Adenosine_kin PF04008.14 CRG84866.1 - 0.13 12.1 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Adenosine specific kinase HIT PF01230.23 CRG84869.1 - 1.2e-15 58.0 0.1 3.7e-15 56.4 0.1 1.7 2 0 0 2 2 2 1 HIT domain CwfJ_C_1 PF04677.15 CRG84869.1 - 0.0059 16.5 0.1 0.047 13.6 0.1 2.2 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DcpS_C PF11969.8 CRG84869.1 - 0.031 14.8 0.0 0.05 14.1 0.0 1.3 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding Cyclin_N PF00134.23 CRG84870.1 - 3.5e-47 159.3 0.1 6.3e-45 152.0 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 CRG84870.1 - 6e-37 126.4 0.3 1.1e-36 125.5 0.3 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain Macoilin PF09726.9 CRG84870.1 - 5.2 5.5 7.0 6.8 5.1 7.0 1.1 1 0 0 1 1 1 0 Macoilin family Ribosomal_L2_C PF03947.18 CRG84871.1 - 9.3e-52 174.5 3.6 2.5e-50 169.9 3.6 2.5 1 1 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CRG84871.1 - 3.6e-24 84.5 0.3 8.2e-24 83.4 0.3 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain RicinB_lectin_2 PF14200.6 CRG84872.1 - 1e-36 125.5 26.8 5.7e-20 71.8 3.8 3.8 2 1 2 4 4 4 3 Ricin-type beta-trefoil lectin domain-like Glyco_hydro_76 PF03663.14 CRG84872.1 - 7.3e-24 85.0 15.2 1.2e-23 84.2 15.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Ricin_B_lectin PF00652.22 CRG84872.1 - 5.8e-10 39.5 6.3 5.8e-10 39.5 6.3 1.8 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Glyco_hydro_88 PF07470.13 CRG84872.1 - 4.8e-08 32.5 3.9 3.8e-07 29.5 0.6 2.2 1 1 2 3 3 3 2 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 CRG84872.1 - 0.00027 19.6 0.0 0.026 13.0 0.2 2.2 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 C5-epim_C PF06662.13 CRG84872.1 - 0.0022 17.6 3.5 7 6.1 0.2 3.5 2 2 1 3 3 3 3 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.11 CRG84872.1 - 0.0028 16.9 0.2 0.13 11.4 0.1 2.3 1 1 0 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Pkinase_fungal PF17667.1 CRG84873.1 - 2.6e-49 168.1 0.0 4.4e-49 167.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase WD40 PF00400.32 CRG84873.1 - 1.3e-20 73.3 11.3 0.00016 22.4 0.0 8.3 8 0 0 8 8 8 5 WD domain, G-beta repeat Fungal_trans PF04082.18 CRG84873.1 - 4.4e-15 55.4 0.0 1e-14 54.2 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain ANAPC4_WD40 PF12894.7 CRG84873.1 - 6.3e-14 52.0 0.0 0.0016 18.7 0.0 5.6 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 CRG84873.1 - 2.3e-09 37.2 10.6 5.3e-09 36.0 10.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cytochrom_D1 PF02239.16 CRG84873.1 - 0.0001 20.9 0.0 0.17 10.4 0.0 2.4 2 0 0 2 2 2 2 Cytochrome D1 heme domain Pkinase PF00069.25 CRG84873.1 - 0.0045 16.4 0.0 0.0075 15.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain F-box-like PF12937.7 CRG84875.1 - 0.00032 20.5 0.3 0.00074 19.4 0.3 1.6 1 0 0 1 1 1 1 F-box-like Ribonuc_P_40 PF08584.11 CRG84876.1 - 4.6e-67 226.3 0.0 6.9e-67 225.7 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit DUF2555 PF10742.9 CRG84876.1 - 0.0071 16.1 0.1 1.8 8.5 0.1 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF2555) Dna2 PF08696.11 CRG84877.1 - 8.8e-70 234.7 0.5 2e-69 233.5 0.5 1.6 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_12 PF13087.6 CRG84877.1 - 3.5e-55 186.7 0.0 4.4e-53 179.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CRG84877.1 - 2.4e-33 116.0 0.5 6.4e-17 62.2 0.0 2.9 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 CRG84877.1 - 1.3e-14 54.4 0.0 2.4e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG84877.1 - 7.3e-13 49.1 0.2 2.6e-12 47.3 0.2 2.0 1 0 0 1 1 1 1 AAA domain Cas_Cas4 PF01930.17 CRG84877.1 - 1.4e-10 41.5 1.0 1.5e-09 38.2 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 CRG84877.1 - 5.4e-10 39.6 0.2 5.4e-10 39.6 0.2 1.7 2 0 0 2 2 1 1 PD-(D/E)XK nuclease superfamily Viral_helicase1 PF01443.18 CRG84877.1 - 1.1e-07 31.8 1.2 0.35 10.6 0.0 3.8 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 CRG84877.1 - 6.1e-05 22.7 0.5 0.00035 20.2 0.3 2.4 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 CRG84877.1 - 0.00012 21.9 0.0 0.00031 20.6 0.0 1.7 1 0 0 1 1 1 1 Helicase Csa1 PF06023.12 CRG84877.1 - 0.00036 20.0 0.9 0.001 18.5 0.9 1.7 1 1 0 1 1 1 1 CRISPR-associated exonuclease Csa1 PIF1 PF05970.14 CRG84877.1 - 0.0012 18.1 0.1 0.0031 16.7 0.1 1.7 1 1 0 1 1 1 1 PIF1-like helicase SRP54 PF00448.22 CRG84877.1 - 0.0012 18.5 0.1 0.0023 17.6 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_16 PF13191.6 CRG84877.1 - 0.0026 18.2 0.0 0.0075 16.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 CRG84877.1 - 0.0073 15.6 0.0 0.015 14.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 CRG84877.1 - 0.0098 15.9 0.1 0.035 14.2 0.1 1.9 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ResIII PF04851.15 CRG84877.1 - 0.024 14.7 0.1 0.065 13.2 0.1 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 CRG84877.1 - 0.027 14.0 0.0 0.073 12.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region MobB PF03205.14 CRG84877.1 - 0.029 14.3 0.1 0.068 13.1 0.1 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_25 PF13481.6 CRG84877.1 - 0.05 13.2 0.0 0.21 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CRG84877.1 - 0.071 12.7 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 CRG84877.1 - 0.094 12.6 0.2 0.26 11.2 0.2 1.7 1 0 0 1 1 1 0 NTPase AAA PF00004.29 CRG84877.1 - 0.12 12.8 0.0 0.39 11.1 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CRG84877.1 - 0.12 12.9 0.0 0.45 11.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 CRG84877.1 - 0.15 11.0 0.1 0.3 10.0 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 CRG84877.1 - 0.18 11.9 2.4 0.14 12.2 0.3 1.9 2 0 0 2 2 1 0 Helicase HerA, central domain ESSS PF10183.9 CRG84878.1 - 1.8e-18 66.7 0.0 2.4e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) CN_hydrolase PF00795.22 CRG84879.1 - 4.7e-53 180.2 0.0 5.3e-53 180.0 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase RNB PF00773.19 CRG84880.1 - 6.3e-99 331.4 0.1 9.1e-99 330.9 0.1 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 CRG84880.1 - 2e-31 108.7 0.0 4.5e-31 107.6 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 CRG84880.1 - 5.3e-25 87.2 0.5 1.3e-24 85.9 0.5 1.7 1 0 0 1 1 1 1 S1 domain OB_Dis3 PF17849.1 CRG84880.1 - 1.4e-20 73.1 0.0 4.4e-20 71.5 0.0 2.0 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 CRG84880.1 - 5.4e-10 39.7 0.1 1.3e-09 38.5 0.1 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 CRG84880.1 - 7.6e-09 35.6 0.0 3.7e-05 23.8 0.0 3.0 3 0 0 3 3 3 2 Cold shock domain LIM PF00412.22 CRG84882.1 - 1.3e-29 102.2 21.0 2.1e-10 40.7 4.0 3.7 3 1 0 3 3 3 3 LIM domain Zn_ribbon_recom PF13408.6 CRG84882.1 - 0.041 14.4 3.1 0.08 13.5 0.2 2.7 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DZR PF12773.7 CRG84882.1 - 1.1 9.3 27.2 0.17 11.9 1.8 4.3 1 1 2 3 3 3 0 Double zinc ribbon Paired_CXXCH_1 PF09699.10 CRG84882.1 - 8.3 6.3 8.5 0.93 9.3 0.2 3.1 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Methyltransf_4 PF02390.17 CRG84883.1 - 1.7e-44 151.3 0.7 7e-30 103.7 0.0 3.1 2 1 1 3 3 3 3 Putative methyltransferase Methyltransf_25 PF13649.6 CRG84883.1 - 0.021 15.5 0.1 0.25 12.1 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain MTS PF05175.14 CRG84883.1 - 0.024 14.2 0.1 0.37 10.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain DUF913 PF06025.12 CRG84883.1 - 0.027 13.4 0.1 0.87 8.5 0.0 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Methyltransf_12 PF08242.12 CRG84883.1 - 0.036 14.8 0.0 0.16 12.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 CRG84883.1 - 0.094 12.7 0.1 0.3 11.1 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 CRG84883.1 - 0.095 12.5 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain ESCRT-II PF05871.12 CRG84885.1 - 7.6e-46 155.8 0.0 1e-45 155.4 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit PTCB-BRCT PF12738.7 CRG84886.1 - 1.7e-37 127.2 0.2 2.3e-20 72.3 0.2 6.4 6 1 0 6 6 6 4 twin BRCT domain RTT107_BRCT_5 PF16770.5 CRG84886.1 - 1.5e-36 124.3 0.0 2.5e-33 113.9 0.0 3.7 4 0 0 4 4 4 2 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 CRG84886.1 - 1.3e-34 118.4 0.0 1.5e-08 34.9 0.0 6.8 6 1 0 6 6 6 5 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CRG84886.1 - 8e-30 103.1 0.0 7.1e-06 26.3 0.0 6.4 6 0 0 6 6 6 5 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CRG84886.1 - 4.2e-12 46.2 0.0 4.9e-05 23.5 0.0 4.1 4 0 0 4 4 4 3 DNA ligase 3 BRCT domain Abhydrolase_6 PF12697.7 CRG84887.1 - 3e-15 57.4 1.6 5.5e-15 56.6 1.6 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG84887.1 - 1.1e-06 28.2 0.0 1.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG84887.1 - 0.024 14.3 0.0 0.056 13.1 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 CRG84887.1 - 0.096 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Ceramidase PF05875.12 CRG84888.1 - 8.3e-107 356.5 8.2 9.9e-107 356.3 8.2 1.0 1 0 0 1 1 1 1 Ceramidase DUF4381 PF14316.6 CRG84888.1 - 2 8.6 7.0 4.5 7.5 2.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF4131 PF13567.6 CRG84888.1 - 4.8 6.8 10.2 0.46 10.1 1.7 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4131) Prefoldin_2 PF01920.20 CRG84889.1 - 1.5e-21 76.4 2.8 1.8e-21 76.1 2.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit T6PP_N PF18572.1 CRG84889.1 - 0.0028 17.5 1.7 0.0093 15.8 1.7 1.9 1 1 0 1 1 1 1 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain CCDC-167 PF15188.6 CRG84889.1 - 0.018 15.4 0.8 0.036 14.4 0.7 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 FlxA PF14282.6 CRG84889.1 - 0.032 14.2 7.5 0.54 10.3 0.2 2.3 2 0 0 2 2 2 0 FlxA-like protein DUF4618 PF15397.6 CRG84889.1 - 0.039 13.4 2.1 0.45 9.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DUF3450 PF11932.8 CRG84889.1 - 0.04 13.2 2.4 0.44 9.8 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF5082 PF16888.5 CRG84889.1 - 0.046 14.0 4.0 1.6 9.0 3.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) TSC22 PF01166.18 CRG84889.1 - 0.058 13.7 1.8 0.57 10.5 0.2 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF4200 PF13863.6 CRG84889.1 - 0.17 12.3 3.6 9.4 6.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Fib_alpha PF08702.10 CRG84889.1 - 0.32 11.2 3.4 4.4 7.5 0.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family YabA PF06156.13 CRG84889.1 - 0.38 11.4 4.4 17 6.1 4.4 2.0 1 1 0 1 1 1 0 Initiation control protein YabA Csm1_N PF18504.1 CRG84889.1 - 6.2 7.2 7.9 1.5 9.2 0.7 2.6 2 1 0 2 2 2 0 Csm1 N-terminal domain DUF4400 PF14348.6 CRG84892.1 - 0.18 11.3 0.3 0.36 10.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) Mito_carr PF00153.27 CRG84893.1 - 2.3e-53 178.1 2.6 8.4e-19 67.3 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein CYYR1 PF10873.8 CRG84895.1 - 0.0018 18.7 1.0 0.0018 18.7 1.0 2.8 3 1 2 5 5 5 1 Cysteine and tyrosine-rich protein 1 Glycophorin_A PF01102.18 CRG84895.1 - 0.0067 16.7 0.1 0.02 15.1 0.1 1.8 1 0 0 1 1 1 1 Glycophorin A TMIE PF16038.5 CRG84895.1 - 0.044 13.6 1.3 0.088 12.7 1.3 1.4 1 0 0 1 1 1 0 TMIE protein EphA2_TM PF14575.6 CRG84895.1 - 0.055 14.3 0.0 18 6.3 0.1 2.6 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF202 PF02656.15 CRG84895.1 - 0.069 13.6 1.0 4.7 7.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Gram_pos_anchor PF00746.21 CRG84895.1 - 1.5 8.8 0.0 1.5 8.8 0.0 3.3 3 0 0 3 3 3 0 LPXTG cell wall anchor motif Podoplanin PF05808.11 CRG84895.1 - 1.6 8.8 11.0 14 5.7 11.1 2.3 2 1 0 2 2 2 0 Podoplanin Rhodanese PF00581.20 CRG84896.1 - 5.4e-08 33.3 0.0 7.9e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain GST_N_3 PF13417.6 CRG84898.1 - 3.5e-13 49.7 0.0 1.8e-12 47.5 0.0 2.2 3 1 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG84898.1 - 1.8e-12 47.3 0.0 2.6e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CRG84898.1 - 3.6e-10 40.1 0.0 1.8e-09 37.8 0.0 2.2 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG84898.1 - 3.6e-06 27.2 0.0 9.5e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG84898.1 - 3.7e-05 23.8 0.1 6.1e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG84898.1 - 0.00035 20.5 0.0 0.00072 19.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain motB PF17613.2 CRG84898.1 - 0.046 13.6 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 Modifier of transcription FAD_binding_3 PF01494.19 CRG84899.1 - 2.5e-05 23.7 0.0 9.8e-05 21.7 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG84899.1 - 0.071 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AP_endonuc_2 PF01261.24 CRG84900.1 - 1.2e-32 113.1 0.0 1.4e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Rcd1 PF04078.13 CRG84901.1 - 2.1e-126 420.5 3.6 2.7e-126 420.1 3.6 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like DHquinase_II PF01220.19 CRG84901.1 - 1.1e-43 148.2 0.8 1.8e-43 147.5 0.0 1.8 2 0 0 2 2 2 1 Dehydroquinase class II TMEM156 PF15106.6 CRG84901.1 - 0.094 12.1 0.1 2 7.8 0.0 2.4 2 0 0 2 2 2 0 TMEM156 protein family baeRF_family10 PF18854.1 CRG84901.1 - 0.31 11.3 12.0 1.2 9.3 8.5 2.4 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 CnrY PF17524.2 CRG84901.1 - 0.31 11.3 2.6 2.2 8.6 0.1 2.7 2 0 0 2 2 2 0 Anti-sigma factor CnrY ArabFuran-catal PF09206.11 CRG84902.1 - 1.5e-146 487.7 9.5 1.5e-146 487.7 9.5 1.5 2 0 0 2 2 2 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 CRG84902.1 - 1.5e-56 190.2 1.1 2.3e-56 189.7 1.1 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain DUF659 PF04937.15 CRG84903.1 - 1.5e-15 57.4 0.0 2.7e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF 659) Dimer_Tnp_hAT PF05699.14 CRG84903.1 - 2.7e-05 23.9 0.3 0.00012 21.8 0.1 2.2 2 0 0 2 2 2 1 hAT family C-terminal dimerisation region NAD_binding_4 PF07993.12 CRG84906.1 - 5e-34 117.6 0.0 9.6e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG84906.1 - 1.2e-24 86.8 0.0 1.8e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CRG84906.1 - 1.7e-10 40.8 0.0 3.1e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG84906.1 - 0.00026 21.3 0.1 0.00072 19.9 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CRG84906.1 - 0.0087 16.0 0.0 0.054 13.4 0.0 2.2 2 0 0 2 2 2 1 KR domain RmlD_sub_bind PF04321.17 CRG84906.1 - 0.18 10.9 0.3 1.4 7.9 0.0 2.3 3 0 0 3 3 3 0 RmlD substrate binding domain PHD PF00628.29 CRG84907.1 - 2.3e-07 30.6 9.5 5.6e-07 29.4 9.5 1.7 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CRG84907.1 - 0.22 11.1 9.7 0.038 13.5 5.5 1.9 2 0 0 2 2 2 0 PHD-finger zf-RING_9 PF13901.6 CRG84907.1 - 8.1 6.4 9.4 13 5.7 9.4 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon HMG_box PF00505.19 CRG84909.1 - 2.8e-10 40.5 1.2 4.8e-10 39.7 1.2 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box MATalpha_HMGbox PF04769.12 CRG84909.1 - 0.1 11.9 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box CobT PF06213.12 CRG84910.1 - 0.51 9.7 44.3 0.69 9.3 44.3 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 CRG84910.1 - 1.3 7.1 51.4 1.4 7.0 51.4 1.0 1 0 0 1 1 1 0 Nop14-like family Mpp10 PF04006.12 CRG84910.1 - 2.2 6.6 51.4 2.6 6.4 51.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Paf1 PF03985.13 CRG84910.1 - 5.5 5.9 52.1 7.6 5.4 52.1 1.3 1 0 0 1 1 1 0 Paf1 DUF5427 PF10310.9 CRG84910.1 - 5.7 5.8 32.7 7 5.5 32.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 CRG84910.1 - 5.8 6.7 37.7 6.6 6.5 37.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 CRG84910.1 - 9.6 5.1 22.2 12 4.8 22.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PIP5K PF01504.18 CRG84910.1 - 9.9 5.3 14.7 11 5.1 14.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Sulfate_transp PF00916.20 CRG84911.1 - 1.3e-59 201.9 26.6 2.1e-59 201.2 26.6 1.2 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 CRG84911.1 - 1.7e-15 56.8 0.0 3.4e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Sld5 PF05916.11 CRG84911.1 - 1.9e-11 44.3 0.0 5e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 GINS complex protein STAS PF01740.21 CRG84911.1 - 2.6e-09 36.7 0.2 4.8e-09 35.9 0.2 1.4 1 0 0 1 1 1 1 STAS domain DUF1524 PF07510.11 CRG84911.1 - 1e-08 35.1 0.1 2.1e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) Peptidase_S26 PF10502.9 CRG84911.1 - 0.058 13.2 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Signal peptidase, peptidase S26 Spt20 PF12090.8 CRG84911.1 - 0.1 12.2 3.9 0.19 11.3 3.9 1.3 1 0 0 1 1 1 0 Spt20 family PH_6 PF15406.6 CRG84912.1 - 1.5e-37 128.3 5.7 1.5e-37 128.3 5.7 3.3 3 1 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 CRG84912.1 - 5.5e-07 30.0 0.0 2.1e-06 28.2 0.0 2.1 1 1 0 1 1 1 1 PH domain Rsc14 PF08586.10 CRG84912.1 - 0.13 13.1 7.6 0.85 10.5 0.1 3.4 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit DUF1768 PF08719.11 CRG84913.1 - 5.8e-57 192.4 0.0 7.3e-57 192.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) NACHT PF05729.12 CRG84914.1 - 2e-15 57.1 0.0 5.6e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 NACHT domain HEAT_2 PF13646.6 CRG84914.1 - 3.7e-15 56.1 11.9 1.1e-08 35.4 4.1 4.4 3 2 2 5 5 4 4 HEAT repeats NB-ARC PF00931.22 CRG84914.1 - 1.1e-07 31.4 0.0 2.1e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain NLRC4_HD2 PF17776.1 CRG84914.1 - 1.6e-06 28.7 0.0 1.9e-05 25.2 0.0 3.0 3 0 0 3 3 1 1 NLRC4 helical domain HD2 HEAT_EZ PF13513.6 CRG84914.1 - 2.2e-06 28.0 3.3 0.0017 18.8 0.4 4.5 4 0 0 4 4 4 1 HEAT-like repeat AAA_16 PF13191.6 CRG84914.1 - 1.7e-05 25.2 1.4 0.00014 22.2 0.0 3.1 2 2 1 3 3 3 1 AAA ATPase domain Arm PF00514.23 CRG84914.1 - 2.4e-05 24.2 0.2 0.39 10.8 0.0 3.4 2 1 1 3 3 3 2 Armadillo/beta-catenin-like repeat bZIP_2 PF07716.15 CRG84914.1 - 3.9e-05 23.6 6.2 3.9e-05 23.6 6.2 2.4 2 0 0 2 2 1 1 Basic region leucine zipper HEAT PF02985.22 CRG84914.1 - 0.00013 22.0 3.3 0.055 13.7 0.1 4.1 5 0 0 5 5 2 1 HEAT repeat AAA PF00004.29 CRG84914.1 - 0.0002 21.8 0.0 0.002 18.5 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) bZIP_1 PF00170.21 CRG84914.1 - 0.00022 21.2 6.2 0.00022 21.2 6.2 2.8 2 0 0 2 2 2 1 bZIP transcription factor AAA_22 PF13401.6 CRG84914.1 - 0.00022 21.5 0.0 0.0014 18.9 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 CRG84914.1 - 0.0023 18.5 0.0 0.014 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CRG84914.1 - 0.0061 17.0 0.0 0.073 13.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CRG84914.1 - 0.0067 16.5 0.0 0.024 14.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain RasGEF_N_2 PF14663.6 CRG84914.1 - 0.017 15.5 0.0 1.3 9.4 0.0 3.6 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain MeaB PF03308.16 CRG84914.1 - 0.029 13.4 0.0 0.059 12.3 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Adaptin_N PF01602.20 CRG84914.1 - 0.029 12.9 2.5 0.073 11.6 1.5 2.1 2 1 0 2 2 2 0 Adaptin N terminal region NTPase_1 PF03266.15 CRG84914.1 - 0.031 14.2 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.6 CRG84914.1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 CRG84914.1 - 0.069 13.3 0.0 7.2 6.7 0.0 2.7 2 0 0 2 2 2 0 Torsin ATPase_2 PF01637.18 CRG84914.1 - 0.11 12.4 0.0 0.36 10.7 0.0 1.9 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CRG84914.1 - 0.11 12.5 0.0 4.4 7.3 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 CRG84914.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 CRG84914.1 - 0.13 12.6 0.0 0.69 10.3 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Zeta_toxin PF06414.12 CRG84914.1 - 0.17 11.1 0.0 0.4 9.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TPR_20 PF14561.6 CRG84914.1 - 0.85 10.0 3.0 3.3 8.1 0.3 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat HEAT_PBS PF03130.16 CRG84914.1 - 4.1 8.4 4.6 1.9e+02 3.2 0.0 4.1 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat Asn_synthase PF00733.21 CRG84916.1 - 6.3e-13 49.1 0.0 0.00077 19.2 0.0 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 CRG84916.1 - 1.7e-05 24.8 0.0 0.00032 20.6 0.0 2.3 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 CRG84916.1 - 0.0043 16.5 0.0 0.008 15.6 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein VPS9 PF02204.18 CRG84917.1 - 6.7e-30 103.4 0.0 1.2e-29 102.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 CRG84917.1 - 9.9e-15 54.6 0.2 2.6e-14 53.2 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) Mac PF12464.8 CRG84917.1 - 3.2e-11 43.3 0.0 7.8e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 CRG84917.1 - 1.1e-10 40.7 5.3 3.4e-09 36.0 2.8 2.9 3 0 0 3 3 3 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG84917.1 - 1.3e-09 37.7 3.8 3.2e-09 36.4 2.1 2.5 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase CUE PF02845.16 CRG84917.1 - 3.4e-08 33.0 0.1 3.2e-07 29.9 0.0 2.3 2 0 0 2 2 2 1 CUE domain FSA_C PF10479.9 CRG84918.1 - 5.6 5.0 10.0 6.1 4.9 10.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Fungal_trans PF04082.18 CRG84919.1 - 1.5e-12 47.1 1.2 2.7e-12 46.3 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84919.1 - 5.4e-07 29.6 9.8 5.4e-07 29.6 9.8 2.5 4 0 0 4 4 4 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rox3 PF08633.10 CRG84920.1 - 4.3e-63 213.3 0.4 9.3e-63 212.2 0.4 1.5 1 0 0 1 1 1 1 Rox3 mediator complex subunit Fungal_trans PF04082.18 CRG84920.1 - 2.1e-12 46.7 0.0 4.2e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84920.1 - 8.1e-09 35.5 10.5 1.4e-08 34.7 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4202 PF13875.6 CRG84921.1 - 1.2e-78 263.3 3.0 1.4e-78 263.1 3.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) RuvA_C PF07499.13 CRG84921.1 - 0.1 13.1 1.8 14 6.2 0.0 2.7 3 0 0 3 3 3 0 RuvA, C-terminal domain VIT1 PF01988.19 CRG84922.1 - 2.7e-61 207.2 4.5 3.3e-61 206.9 4.5 1.1 1 0 0 1 1 1 1 VIT family PMT_4TMC PF16192.5 CRG84922.1 - 0.048 13.2 0.9 0.068 12.7 0.9 1.1 1 0 0 1 1 1 0 C-terminal four TMM region of protein-O-mannosyltransferase Glyco_hydro_76 PF03663.14 CRG84923.1 - 4.4e-101 339.0 17.5 5.7e-101 338.7 17.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF202 PF02656.15 CRG84925.1 - 3e-16 59.6 0.0 4.8e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF202) Peptidase_A4 PF01828.17 CRG84926.1 - 5e-66 222.1 3.8 6.3e-66 221.8 3.8 1.1 1 0 0 1 1 1 1 Peptidase A4 family Hydrolase_4 PF12146.8 CRG84927.1 - 5.7e-13 48.7 0.0 2.2e-12 46.7 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG84927.1 - 2.3e-12 47.1 0.0 1.6e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG84927.1 - 5.9e-10 40.1 0.0 7.7e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family UPF0227 PF05728.12 CRG84927.1 - 1.7e-06 28.1 0.0 3.1e-05 24.0 0.0 2.1 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_3 PF07859.13 CRG84927.1 - 6.9e-05 22.8 0.0 0.00028 20.8 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 CRG84927.1 - 0.0003 20.5 0.0 0.0036 17.0 0.0 2.0 2 0 0 2 2 2 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 CRG84927.1 - 0.00032 20.2 0.0 0.39 10.2 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Palm_thioest PF02089.15 CRG84927.1 - 0.003 17.4 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF885 PF05960.11 CRG84927.1 - 0.042 13.5 0.0 0.055 13.1 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Esterase PF00756.20 CRG84927.1 - 0.07 12.8 0.0 0.092 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative esterase LIDHydrolase PF10230.9 CRG84927.1 - 0.21 11.1 0.0 0.49 9.9 0.0 1.3 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase FAD_binding_4 PF01565.23 CRG84928.1 - 2.6e-10 40.2 1.1 7.2e-10 38.7 1.1 1.8 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG84928.1 - 3.2e-09 36.8 0.7 6.1e-09 35.8 0.7 1.4 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 CRG84928.1 - 0.16 11.4 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding MARVEL PF01284.23 CRG84930.1 - 1.8e-07 31.3 11.4 3.1e-07 30.5 11.4 1.4 1 1 0 1 1 1 1 Membrane-associating domain DUF4328 PF14219.6 CRG84930.1 - 0.044 13.3 0.2 0.044 13.3 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4328) Pyr_redox_2 PF07992.14 CRG84932.1 - 1.8e-12 47.1 0.0 1.4e-10 40.9 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CRG84932.1 - 6e-11 41.5 0.0 4e-10 38.8 0.0 2.1 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG84932.1 - 4e-09 36.2 0.0 1.6e-06 27.6 0.0 3.2 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG84932.1 - 2.6e-08 33.4 0.0 2.9e-05 23.4 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CRG84932.1 - 1.5e-05 25.2 3.9 0.0001 22.5 0.3 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG84932.1 - 5.8e-05 23.1 1.9 0.0017 18.3 0.2 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 CRG84932.1 - 9.4e-05 21.9 0.0 0.34 10.2 0.0 2.9 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase DAO PF01266.24 CRG84932.1 - 0.00036 20.2 2.6 0.41 10.2 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG84932.1 - 0.0032 18.0 0.0 4 8.1 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG84932.1 - 0.026 13.8 0.1 0.026 13.8 0.1 1.9 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 CRG84932.1 - 0.064 12.0 0.0 0.4 9.3 0.3 1.9 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_3 PF01494.19 CRG84932.1 - 0.11 11.7 0.0 0.11 11.7 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain SURF4 PF02077.15 CRG84933.1 - 9.6e-100 333.6 8.2 1.1e-99 333.4 8.2 1.0 1 0 0 1 1 1 1 SURF4 family HR_lesion PF05514.11 CRG84933.1 - 0.36 11.0 7.6 0.79 9.9 2.2 3.0 3 0 0 3 3 3 0 HR-like lesion-inducing Ank_2 PF12796.7 CRG84938.1 - 1.2e-40 138.0 3.1 2.3e-14 53.7 0.0 5.3 3 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG84938.1 - 1.8e-39 133.6 5.6 7e-12 45.6 0.2 9.2 4 2 6 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG84938.1 - 2.5e-32 107.3 11.2 3e-06 27.1 0.0 9.3 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 CRG84938.1 - 6.9e-32 109.1 8.8 3.4e-05 24.0 0.1 8.1 4 3 4 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 CRG84938.1 - 2.3e-31 106.8 12.2 2.3e-08 34.1 0.1 8.7 9 0 0 9 9 9 6 Ankyrin repeat RXLR_WY PF18634.1 CRG84938.1 - 0.11 12.4 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 RXLR phytopathogen effector protein WY-domain Asp PF00026.23 CRG84939.1 - 5.3e-22 78.7 0.0 9.4e-11 41.7 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG84939.1 - 0.00088 19.6 0.0 0.0012 19.1 0.0 1.2 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal DMRT-like PF15791.5 CRG84939.1 - 0.2 12.1 0.1 1.7 9.0 0.0 2.0 2 0 0 2 2 2 0 Doublesex-and mab-3-related transcription factor C1 and C2 Glyco_hydro_31 PF01055.26 CRG84940.1 - 1.6e-145 485.7 7.7 2.1e-145 485.3 7.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG84940.1 - 8.3e-37 125.9 0.1 1.7e-36 124.9 0.1 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG84940.1 - 5.5e-11 42.6 0.5 1.5e-10 41.3 0.5 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like IU_nuc_hydro PF01156.19 CRG84941.1 - 6.1e-54 183.6 0.1 9.1e-54 183.1 0.1 1.2 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF2249 PF10006.9 CRG84941.1 - 0.049 13.5 0.1 0.2 11.6 0.1 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) Transketolase_C PF02780.20 CRG84941.1 - 0.083 12.8 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Transketolase, C-terminal domain DUF4816 PF16086.5 CRG84943.1 - 3.5 7.6 12.5 7.6 6.5 12.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4816) HLH PF00010.26 CRG84944.1 - 8.4e-14 51.3 0.9 1.6e-13 50.4 0.9 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mitofilin PF09731.9 CRG84944.1 - 0.18 10.6 7.7 0.26 10.1 7.7 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein LSM PF01423.22 CRG84948.1 - 5.9e-17 61.1 0.2 9.3e-17 60.5 0.2 1.3 1 0 0 1 1 1 1 LSM domain WH2 PF02205.20 CRG84949.1 - 2.8e-09 36.5 0.1 6e-09 35.4 0.1 1.6 1 0 0 1 1 1 1 WH2 motif PMC2NT PF08066.12 CRG84950.1 - 0.00025 21.6 1.0 0.24 12.1 0.1 2.5 1 1 1 2 2 2 2 PMC2NT (NUC016) domain DUF4698 PF15769.5 CRG84950.1 - 0.23 10.5 3.7 0.3 10.1 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Ribosomal_L1 PF00687.21 CRG84951.1 - 1e-45 156.0 0.1 1.1e-45 155.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family SNF PF00209.18 CRG84951.1 - 0.038 12.7 0.1 0.051 12.3 0.1 1.1 1 0 0 1 1 1 0 Sodium:neurotransmitter symporter family Acetyltransf_1 PF00583.25 CRG84952.1 - 9.4e-12 45.2 0.0 1.3e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG84952.1 - 1.8e-09 37.9 0.0 2.9e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG84952.1 - 3.5e-08 33.4 0.0 5.8e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG84952.1 - 1.4e-05 25.0 0.1 6.5e-05 22.8 0.1 2.1 2 1 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 CRG84952.1 - 0.00055 20.0 0.0 0.0009 19.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CRG84952.1 - 0.0048 17.0 0.1 0.0088 16.1 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 CRG84952.1 - 0.053 13.5 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_3 PF13302.7 CRG84952.1 - 0.066 13.9 0.0 0.095 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CRG84952.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pox_ATPase-GT PF10640.9 CRG84952.1 - 0.11 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase Arf PF00025.21 CRG84953.1 - 1.9e-79 265.2 0.2 2.2e-79 264.9 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 CRG84953.1 - 5.1e-15 55.4 0.0 6.3e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 CRG84953.1 - 3e-14 53.3 0.0 4.3e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CRG84953.1 - 2.2e-13 50.1 1.3 1.9e-09 37.1 0.5 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 CRG84953.1 - 2.9e-13 49.7 0.0 3.3e-13 49.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 CRG84953.1 - 2.1e-10 40.4 0.0 2.6e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CRG84953.1 - 4.3e-06 26.8 0.0 6.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CRG84953.1 - 0.011 15.1 0.4 0.022 14.1 0.4 1.7 1 1 0 1 1 1 0 6-phosphofructo-2-kinase DUF3405 PF11885.8 CRG84955.1 - 8.8e-230 763.7 0.3 1.1e-229 763.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) MFS_1 PF07690.16 CRG84955.1 - 2.2e-45 155.2 50.0 2.2e-45 155.2 50.0 3.1 3 1 0 3 3 3 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG84955.1 - 3.1e-18 65.5 10.5 6.6e-18 64.5 10.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Gpr1_Fun34_YaaH PF01184.19 CRG84955.1 - 3.3e-18 66.0 22.7 3.3e-18 66.0 22.7 2.2 3 0 0 3 3 3 1 GPR1/FUN34/yaaH family Sugar_tr PF00083.24 CRG84955.1 - 1.7e-14 53.5 9.2 1.7e-14 53.5 9.2 3.8 3 1 0 4 4 4 2 Sugar (and other) transporter JSRP PF15312.6 CRG84955.1 - 0.073 13.0 0.1 0.34 10.9 0.1 2.2 1 1 0 1 1 1 0 Junctional sarcoplasmic reticulum protein Pyr_redox_3 PF13738.6 CRG84959.1 - 2.6e-24 86.0 0.0 3.8e-22 78.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CRG84959.1 - 1.9e-23 82.7 0.0 4.9e-21 74.7 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG84959.1 - 7.3e-18 64.8 0.1 3.3e-13 49.5 0.0 2.7 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG84959.1 - 5.9e-14 51.9 0.2 5.3e-10 39.0 0.0 3.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CRG84959.1 - 2.2e-08 34.6 0.1 0.004 17.7 0.1 3.3 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CRG84959.1 - 4e-08 32.8 0.2 0.0055 16.1 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CRG84959.1 - 4.3e-08 32.8 0.7 1.7e-05 24.2 0.1 2.5 3 0 0 3 3 3 2 FAD binding domain NAD_binding_9 PF13454.6 CRG84959.1 - 3.5e-06 27.1 0.2 0.18 11.8 0.0 3.9 3 1 1 4 4 4 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CRG84959.1 - 5.5e-06 26.5 0.3 0.00016 21.9 0.0 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain IlvN PF07991.12 CRG84959.1 - 0.00014 21.5 0.2 0.0014 18.2 0.1 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 CRG84959.1 - 0.00023 21.6 0.0 0.0091 16.4 0.1 2.6 2 1 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CRG84959.1 - 0.00066 19.7 0.1 0.074 13.1 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 CRG84959.1 - 0.00074 19.8 0.1 0.35 11.1 0.0 2.7 3 0 0 3 3 2 1 TrkA-N domain 3HCDH_N PF02737.18 CRG84959.1 - 0.00077 19.4 0.2 0.028 14.3 0.1 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 CRG84959.1 - 0.00079 19.1 0.0 1.7 8.3 0.0 2.6 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 CRG84959.1 - 0.0016 17.2 0.1 0.43 9.2 0.0 2.9 3 0 0 3 3 3 1 HI0933-like protein F420_oxidored PF03807.17 CRG84959.1 - 0.0021 18.6 0.0 1.3 9.6 0.0 3.3 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Lycopene_cycl PF05834.12 CRG84959.1 - 0.0052 15.9 0.0 1.2 8.1 0.0 3.2 3 0 0 3 3 3 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CRG84959.1 - 0.0095 15.2 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CRG84959.1 - 0.011 14.9 0.1 0.064 12.3 0.1 2.1 3 0 0 3 3 3 0 FAD binding domain NAD_binding_2 PF03446.15 CRG84959.1 - 0.015 15.5 0.1 0.86 9.8 0.1 2.4 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase GIDA PF01134.22 CRG84959.1 - 0.016 14.3 0.0 10 5.0 0.0 3.1 4 0 0 4 4 4 0 Glucose inhibited division protein A Thi4 PF01946.17 CRG84959.1 - 0.07 12.4 0.0 7.7 5.7 0.0 3.1 4 0 0 4 4 4 0 Thi4 family NAD_Gly3P_dh_N PF01210.23 CRG84959.1 - 0.083 12.9 0.2 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Sod_Cu PF00080.20 CRG84960.1 - 2.8e-11 43.8 0.0 4.6e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Fungal_trans PF04082.18 CRG84961.1 - 7.2e-11 41.6 0.0 1.2e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG84961.1 - 6.4e-08 32.6 10.3 1.1e-07 31.8 10.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dabb PF07876.12 CRG84962.1 - 2.1e-13 50.7 0.7 3.3e-13 50.1 0.7 1.3 1 1 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF3198 PF11433.8 CRG84962.1 - 0.057 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) Ldh_2 PF02615.14 CRG84964.1 - 3.7e-128 427.4 0.2 4.2e-128 427.2 0.2 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Sugar_tr PF00083.24 CRG84965.1 - 4e-95 319.3 12.3 5.1e-95 319.0 12.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG84965.1 - 3.5e-35 121.6 35.2 1.4e-27 96.6 13.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PsbJ PF01788.17 CRG84965.1 - 0.023 14.5 0.4 11 6.0 0.4 3.1 2 0 0 2 2 2 0 PsbJ YMF19 PF02326.15 CRG84965.1 - 0.25 12.1 0.1 0.25 12.1 0.1 2.0 2 0 0 2 2 2 0 Plant ATP synthase F0 adh_short_C2 PF13561.6 CRG84966.1 - 4.9e-54 183.4 2.3 7.5e-54 182.8 2.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG84966.1 - 1.8e-38 132.0 0.4 3.3e-38 131.1 0.4 1.4 1 0 0 1 1 1 1 short chain dehydrogenase SWIRM-assoc_3 PF16498.5 CRG84966.1 - 0.021 15.1 0.6 0.17 12.1 0.3 2.3 2 0 0 2 2 2 0 SWIRM-associated domain at the C-terminal Podoplanin PF05808.11 CRG84967.1 - 0.017 15.2 0.2 0.024 14.7 0.2 1.2 1 0 0 1 1 1 0 Podoplanin OpcA PF07239.11 CRG84967.1 - 0.058 13.1 0.0 0.088 12.5 0.0 1.2 1 0 0 1 1 1 0 Outer membrane protein OpcA SKG6 PF08693.10 CRG84967.1 - 0.15 11.5 0.7 0.37 10.2 0.0 2.0 2 0 0 2 2 2 0 Transmembrane alpha-helix domain MFS_1 PF07690.16 CRG84969.1 - 1.7e-33 116.0 32.7 4.2e-33 114.7 27.2 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84969.1 - 5.1e-10 38.8 3.9 5.1e-10 38.8 3.9 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter Choline_kinase PF01633.20 CRG84971.1 - 7.1e-48 163.0 0.0 1.6e-46 158.6 0.0 2.1 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 CRG84971.1 - 1.1e-08 35.3 1.6 2.8e-08 34.0 0.4 2.2 2 1 0 2 2 2 1 Phosphotransferase enzyme family EcKinase PF02958.20 CRG84971.1 - 0.0059 16.0 0.0 0.018 14.3 0.0 1.8 1 1 0 1 1 1 1 Ecdysteroid kinase CHORD PF04968.12 CRG84973.1 - 4.5e-51 171.4 19.7 9e-27 93.6 6.9 2.2 2 0 0 2 2 2 2 CHORD CS PF04969.16 CRG84973.1 - 1.8e-13 51.3 0.0 2.7e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 CS domain BTK PF00779.19 CRG84973.1 - 0.072 12.9 7.9 1.8 8.4 0.4 3.3 3 0 0 3 3 3 0 BTK motif Pheromone PF08015.11 CRG84973.1 - 0.59 11.2 3.4 1.9 9.6 3.4 1.9 1 1 0 1 1 1 0 Fungal mating-type pheromone DUF836 PF05768.14 CRG84975.1 - 5.1e-14 52.5 0.1 5.8e-14 52.3 0.1 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 CRG84975.1 - 0.01 16.0 0.1 0.017 15.3 0.1 1.5 1 0 0 1 1 1 0 Glutaredoxin Fungal_trans_2 PF11951.8 CRG84976.1 - 0.016 14.0 3.5 0.022 13.6 3.5 1.5 1 1 0 1 1 1 0 Fungal specific transcription factor domain 14-3-3 PF00244.20 CRG84977.1 - 4e-08 33.0 0.4 1e-07 31.7 0.0 1.6 2 0 0 2 2 2 1 14-3-3 protein DUF3237 PF11578.8 CRG84978.1 - 1.4e-46 158.1 0.1 1.5e-46 157.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) RsgI_N PF12791.7 CRG84978.1 - 0.074 13.0 1.1 0.36 10.8 0.0 2.4 3 0 0 3 3 3 0 Anti-sigma factor N-terminus adh_short PF00106.25 CRG84980.1 - 1e-15 57.7 0.4 2e-15 56.8 0.2 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG84980.1 - 4.8e-07 29.8 0.1 7.3e-07 29.3 0.1 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG84980.1 - 6.2e-07 29.2 0.1 9.9e-07 28.5 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CRG84980.1 - 0.014 14.8 0.1 0.11 12.0 0.1 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Ribosomal_L18p PF00861.22 CRG84980.1 - 0.12 12.7 0.1 0.28 11.5 0.1 1.6 1 0 0 1 1 1 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Metallophos PF00149.28 CRG84981.1 - 2.2e-12 47.9 1.4 3.5e-12 47.3 1.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mito_carr PF00153.27 CRG84982.1 - 2.3e-66 219.7 2.5 3.7e-23 81.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CRG84982.1 - 0.0048 16.1 0.6 0.066 12.4 0.0 2.7 2 1 0 2 2 2 1 Gammaproteobacterial serine protease MFS_1 PF07690.16 CRG84983.1 - 6.9e-45 153.5 44.7 2.3e-44 151.8 39.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG84983.1 - 2.6e-05 23.3 10.0 2.6e-05 23.3 10.0 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter DUF1129 PF06570.11 CRG84983.1 - 2.1 7.8 3.9 3 7.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) SnoaL_4 PF13577.6 CRG84985.1 - 1.2e-08 35.2 0.1 1.5e-08 34.8 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CRG84985.1 - 0.0034 17.8 0.0 0.0045 17.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Ring_hydroxyl_B PF00866.18 CRG84985.1 - 0.066 13.3 0.0 0.095 12.8 0.0 1.3 1 1 0 1 1 1 0 Ring hydroxylating beta subunit BRCT_assoc PF12820.7 CRG84986.1 - 0.047 13.5 0.8 0.073 12.9 0.8 1.2 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT Acyl-CoA_dh_1 PF00441.24 CRG84987.1 - 1.4e-34 119.5 0.9 1.9e-34 119.1 0.9 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CRG84987.1 - 2e-23 82.4 0.1 4.3e-23 81.3 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CRG84987.1 - 6.1e-14 52.6 0.0 4e-13 50.0 0.0 2.4 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CRG84987.1 - 3.5e-08 33.8 1.1 5e-08 33.3 1.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain EMP24_GP25L PF01105.24 CRG84989.1 - 1.7e-48 165.0 0.4 2.2e-48 164.6 0.4 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3425 PF11905.8 CRG84992.1 - 5.4e-14 52.2 0.1 1.2e-13 51.1 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CRG84992.1 - 0.00082 19.4 17.6 0.0013 18.8 17.0 1.7 1 1 0 1 1 1 1 bZIP transcription factor LCD1 PF09798.9 CRG84992.1 - 0.019 13.5 1.0 0.025 13.1 1.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein HIP1_clath_bdg PF16515.5 CRG84992.1 - 0.072 13.7 6.5 0.15 12.7 6.5 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 IATP PF04568.12 CRG84992.1 - 0.88 10.0 5.2 1.9 9.0 5.2 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP GLE1 PF07817.13 CRG84993.1 - 2.6e-50 171.0 0.1 1.5e-49 168.5 0.0 1.9 2 0 0 2 2 2 1 GLE1-like protein DUF4778 PF16008.5 CRG84993.1 - 0.74 9.8 20.4 1.2 9.1 20.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) DNA_pack_N PF02500.15 CRG84993.1 - 9.6 5.9 9.8 3.2 7.5 6.7 1.7 1 1 0 1 1 1 0 Probable DNA packing protein, N-terminus RNB PF00773.19 CRG84994.1 - 1.1e-90 304.3 0.0 2.5e-90 303.1 0.0 1.6 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 CRG84994.1 - 1.6e-26 92.2 0.1 7.9e-26 89.9 0.0 2.3 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 CRG84994.1 - 1.4e-25 89.4 0.0 5.8e-25 87.4 0.0 2.2 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Rrp44_CSD1 PF17216.3 CRG84994.1 - 8.9e-05 22.3 0.0 0.00021 21.0 0.0 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 CRG84994.1 - 0.00044 20.4 0.0 0.027 14.6 0.0 2.8 2 0 0 2 2 2 1 Cold shock domain UQ_con PF00179.26 CRG84995.1 - 4.5e-36 123.6 0.0 7.9e-36 122.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CRG84995.1 - 0.02 14.6 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 Prokaryotic E2 family B adh_short_C2 PF13561.6 CRG84997.1 - 3.2e-27 95.6 0.0 4.1e-27 95.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG84997.1 - 5.8e-16 58.5 0.0 8e-16 58.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG84997.1 - 0.0043 17.0 0.0 0.0061 16.5 0.0 1.3 1 0 0 1 1 1 1 KR domain PEP-utilisers_N PF05524.13 CRG84997.1 - 0.021 15.0 0.0 0.37 11.0 0.0 2.2 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal MMgT PF10270.9 CRG84998.1 - 8e-33 112.8 0.0 9.5e-33 112.5 0.0 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter RanGAP1_C PF07834.11 CRG84998.1 - 0.14 11.7 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 RanGAP1 C-terminal domain ApoL PF05461.11 CRG84998.1 - 3.6 6.8 4.6 5 6.3 4.1 1.4 1 1 1 2 2 2 0 Apolipoprotein L EF1_GNE PF00736.19 CRG84999.1 - 4.9e-33 113.2 3.6 1e-32 112.2 3.6 1.5 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 CRG84999.1 - 7.5e-09 35.9 6.9 7.5e-09 35.9 6.9 2.5 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 CRG84999.1 - 0.00056 20.1 0.4 0.0011 19.1 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG84999.1 - 0.00098 19.3 1.6 0.0027 17.9 0.1 2.4 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG84999.1 - 0.0095 15.9 0.2 0.14 12.2 0.2 2.3 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Thioesterase PF00975.20 CRG84999.1 - 0.058 13.5 0.2 0.094 12.8 0.2 1.3 1 0 0 1 1 1 0 Thioesterase domain AAA_2 PF07724.14 CRG85000.1 - 1.2e-45 155.7 0.6 6.8e-44 150.0 0.0 2.7 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CRG85000.1 - 8.4e-36 122.1 2.7 8.4e-36 122.1 2.7 2.5 1 1 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 CRG85000.1 - 1.6e-26 92.1 0.4 5.5e-26 90.4 0.4 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 CRG85000.1 - 3.7e-19 69.4 1.3 3.4e-10 40.5 0.0 2.9 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CRG85000.1 - 4.5e-12 46.2 0.0 2.2e-07 31.0 0.0 3.0 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG85000.1 - 2.8e-09 37.6 7.1 0.00016 22.1 0.2 4.4 3 2 0 3 3 2 2 AAA ATPase domain Sigma54_activat PF00158.26 CRG85000.1 - 5.6e-08 32.7 1.1 0.00019 21.2 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 CRG85000.1 - 1.6e-06 28.4 4.9 0.055 13.7 0.1 4.2 3 3 1 4 4 4 2 AAA domain TniB PF05621.11 CRG85000.1 - 4.9e-06 26.1 0.0 0.015 14.7 0.0 3.7 3 1 0 3 3 2 1 Bacterial TniB protein AAA_14 PF13173.6 CRG85000.1 - 5.6e-06 26.4 0.0 0.048 13.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 CRG85000.1 - 1e-05 25.5 0.1 0.11 12.4 0.0 2.7 2 0 0 2 2 2 2 NACHT domain AAA_7 PF12775.7 CRG85000.1 - 1.3e-05 24.8 0.0 0.034 13.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 CRG85000.1 - 8.6e-05 22.3 0.7 0.063 13.0 0.0 2.6 3 0 0 3 3 2 1 AAA domain IstB_IS21 PF01695.17 CRG85000.1 - 0.00012 21.8 0.0 0.47 10.2 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_28 PF13521.6 CRG85000.1 - 0.00017 21.9 0.4 0.05 13.8 0.0 3.3 3 1 0 3 3 3 1 AAA domain SRP54 PF00448.22 CRG85000.1 - 0.00027 20.6 0.1 0.046 13.3 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_18 PF13238.6 CRG85000.1 - 0.00073 20.1 1.2 1.6 9.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CRG85000.1 - 0.0012 19.2 0.0 0.79 10.1 0.0 3.0 2 0 0 2 2 2 1 RNA helicase FapA PF03961.13 CRG85000.1 - 0.0015 17.2 6.1 0.0028 16.3 6.1 1.4 1 0 0 1 1 1 1 Flagellar Assembly Protein A ATPase_2 PF01637.18 CRG85000.1 - 0.0015 18.5 8.8 5.4 6.8 0.0 4.5 3 2 2 5 5 4 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CRG85000.1 - 0.0021 18.1 0.1 4.1 7.4 0.0 3.1 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 CRG85000.1 - 0.0028 17.9 0.1 1 9.6 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 CRG85000.1 - 0.0037 16.7 1.3 3 7.2 0.1 3.6 3 1 0 3 3 3 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 CRG85000.1 - 0.0043 17.6 2.6 1.5 9.3 0.0 3.4 3 0 0 3 3 3 1 ABC transporter PduV-EutP PF10662.9 CRG85000.1 - 0.0071 16.1 0.0 0.49 10.1 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 CRG85000.1 - 0.0072 16.7 1.8 0.14 12.5 0.3 3.2 2 2 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CRG85000.1 - 0.0083 16.0 1.9 4.1 7.3 0.0 3.2 3 0 0 3 3 3 0 RsgA GTPase AAA_30 PF13604.6 CRG85000.1 - 0.016 14.9 4.3 0.098 12.4 0.0 3.6 3 1 1 4 4 3 0 AAA domain Zeta_toxin PF06414.12 CRG85000.1 - 0.023 14.0 0.0 2.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 CRG85000.1 - 0.029 14.0 0.7 0.44 10.1 0.1 2.8 2 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CRG85000.1 - 0.029 14.5 0.0 12 6.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CRG85000.1 - 0.031 13.4 0.3 0.87 8.7 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF815) RuvB_N PF05496.12 CRG85000.1 - 0.037 13.8 0.6 6.7 6.4 0.0 3.3 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain PhoH PF02562.16 CRG85000.1 - 0.037 13.5 0.2 1 8.7 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_6 PF12774.7 CRG85000.1 - 0.044 12.8 0.0 4.7 6.1 0.0 3.0 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region AAA_21 PF13304.6 CRG85000.1 - 0.051 13.4 1.6 0.48 10.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system UvrD-helicase PF00580.21 CRG85000.1 - 0.057 12.9 5.5 0.61 9.6 0.1 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain NTPase_1 PF03266.15 CRG85000.1 - 0.094 12.6 1.8 1.1 9.1 0.0 3.0 3 0 0 3 3 3 0 NTPase AAA_29 PF13555.6 CRG85000.1 - 0.097 12.4 0.1 6.3 6.6 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain ResIII PF04851.15 CRG85000.1 - 0.1 12.6 4.8 6 6.8 0.1 3.3 3 1 0 4 4 3 0 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.9 CRG85000.1 - 0.14 11.0 2.5 1.2 8.0 0.1 2.7 3 0 0 3 3 2 0 Type IV secretion-system coupling protein DNA-binding domain ATP_bind_1 PF03029.17 CRG85000.1 - 0.23 11.2 2.7 1.4 8.7 0.0 2.7 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein DUF1640 PF07798.11 CRG85000.1 - 0.71 9.9 9.7 1.4 8.9 9.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Seryl_tRNA_N PF02403.22 CRG85000.1 - 1.4 9.2 17.9 1.8 8.8 15.5 2.6 2 0 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 CRG85000.1 - 1.4 8.2 17.1 2.9 7.2 17.1 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 CRG85000.1 - 1.9 8.3 13.3 3.8 7.4 5.8 2.6 1 1 1 2 2 2 0 Septum formation initiator DUF853 PF05872.12 CRG85000.1 - 2.7 6.5 7.0 0.12 10.9 0.1 2.1 3 0 0 3 3 2 0 Bacterial protein of unknown function (DUF853) DUF87 PF01935.17 CRG85000.1 - 3.3 7.7 8.1 30 4.6 0.0 3.4 3 0 0 3 3 3 0 Helicase HerA, central domain UPF0242 PF06785.11 CRG85000.1 - 3.5 7.7 13.1 8 6.5 13.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CRR7 PF12095.8 CRG85000.1 - 3.5 8.1 6.5 7.8 7.0 5.6 2.1 2 0 0 2 2 1 0 Protein CHLORORESPIRATORY REDUCTION 7 V_ATPase_I PF01496.19 CRG85000.1 - 3.8 5.3 5.8 5.2 4.9 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 CRG85000.1 - 4.9 6.0 16.0 8.4 5.2 16.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4407 PF14362.6 CRG85000.1 - 5.9 6.2 7.8 13 5.1 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4446 PF14584.6 CRG85000.1 - 5.9 6.9 6.0 6.8 6.7 4.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4337 PF14235.6 CRG85000.1 - 8.7 6.4 7.3 16 5.6 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MutS_V PF00488.21 CRG85001.1 - 5.2e-39 134.2 0.0 3.3e-37 128.4 0.0 2.4 1 1 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CRG85001.1 - 3.8e-18 66.4 0.0 7.6e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 CRG85001.1 - 0.00053 20.3 0.0 0.0023 18.3 0.0 2.1 2 0 0 2 2 2 1 MutS family domain IV AAA_14 PF13173.6 CRG85001.1 - 0.067 13.2 0.1 0.27 11.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain Sas10 PF09368.10 CRG85002.1 - 1.3e-29 102.5 10.3 1.3e-29 102.5 10.3 3.7 4 0 0 4 4 4 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 CRG85002.1 - 8.5e-14 52.0 0.8 4.6e-13 49.6 0.0 2.6 2 0 0 2 2 2 1 Sas10/Utp3/C1D family adh_short PF00106.25 CRG85003.1 - 3.2e-19 69.2 0.0 4.6e-19 68.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85003.1 - 4.6e-12 46.0 0.0 6.8e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85003.1 - 1.5e-08 34.8 0.0 2.1e-08 34.3 0.0 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG85003.1 - 0.0005 19.6 0.0 0.00079 19.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG85003.1 - 0.00051 19.5 0.0 0.00072 19.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase THF_DHG_CYH_C PF02882.19 CRG85003.1 - 0.001 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ADH_zinc_N PF00107.26 CRG85003.1 - 0.0015 18.5 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 CRG85003.1 - 0.0041 17.5 0.0 0.0073 16.7 0.0 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 CRG85003.1 - 0.0047 16.8 0.0 0.007 16.3 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.8 CRG85003.1 - 0.017 14.9 0.1 0.097 12.4 0.2 2.0 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Sacchrp_dh_NADP PF03435.18 CRG85003.1 - 0.019 15.2 0.0 0.027 14.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_Gly3P_dh_N PF01210.23 CRG85003.1 - 0.055 13.4 0.0 1.6 8.7 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Shikimate_DH PF01488.20 CRG85003.1 - 0.063 13.3 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Lactonase PF10282.9 CRG85003.1 - 0.17 11.1 0.4 2.9 7.0 0.0 2.5 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller FA_hydroxylase PF04116.13 CRG85004.1 - 1.2e-17 64.5 3.8 1.2e-17 64.5 3.8 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Ribosomal_L6e PF01159.19 CRG85006.1 - 6.7e-41 139.3 0.6 1.2e-40 138.5 0.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e GNAT_acetyltr_2 PF13718.6 CRG85006.1 - 0.12 11.8 0.2 0.18 11.2 0.2 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Proteasom_Rpn13 PF04683.13 CRG85007.1 - 7.2e-28 97.0 0.0 1.2e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 CRG85007.1 - 9e-13 48.4 1.1 5.8e-10 39.3 1.6 3.0 2 1 0 2 2 2 2 UCH-binding domain Ion_trans PF00520.31 CRG85008.1 - 7.2e-121 402.0 100.1 1.2e-39 136.0 11.1 4.8 4 1 0 4 4 4 4 Ion transport protein GPHH PF16905.5 CRG85008.1 - 0.00056 19.6 0.0 0.0019 17.9 0.0 1.9 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated EF-hand_1 PF00036.32 CRG85008.1 - 0.023 14.2 0.0 0.065 12.8 0.0 1.9 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 CRG85008.1 - 0.042 13.8 0.0 0.19 11.8 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 CRG85008.1 - 0.096 13.1 0.0 0.32 11.5 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair DUF2149 PF09919.9 CRG85008.1 - 3.4 8.0 4.7 13 6.1 0.1 4.0 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2149) SET PF00856.28 CRG85011.1 - 8.7e-20 71.8 0.0 4.3e-19 69.5 0.0 2.2 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 CRG85011.1 - 3.5e-14 53.4 4.5 3.5e-14 53.4 4.5 2.1 3 0 0 3 3 3 1 Pre-SET motif AWS PF17907.1 CRG85011.1 - 0.00055 19.9 1.2 0.00055 19.9 1.2 2.7 2 0 0 2 2 2 1 AWS domain Dabb PF07876.12 CRG85012.1 - 1.1e-23 83.6 0.0 1.4e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain DUF4390 PF14334.6 CRG85012.1 - 0.19 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4390) Pkinase PF00069.25 CRG85015.1 - 7.3e-69 232.1 0.0 1.1e-68 231.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85015.1 - 5.2e-38 130.8 0.0 1.1e-37 129.8 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 CRG85015.1 - 2e-16 59.5 0.4 3.5e-16 58.7 0.4 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kdo PF06293.14 CRG85015.1 - 2e-05 24.0 0.0 3.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CRG85015.1 - 8.1e-05 22.1 0.0 0.00072 19.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CRG85015.1 - 0.00012 21.2 0.0 0.00019 20.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CRG85015.1 - 0.0019 18.2 0.0 0.0076 16.2 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 CRG85015.1 - 0.071 12.6 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL RIO1 PF01163.22 CRG85015.1 - 0.098 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 RIO1 family DUF1604 PF07713.13 CRG85016.1 - 9.5e-43 143.9 2.4 9.5e-43 143.9 2.4 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF1604) UBD PF16455.5 CRG85016.1 - 1.2e-41 141.1 0.0 2.6e-41 140.1 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-binding domain G-patch PF01585.23 CRG85016.1 - 3.3e-07 30.1 1.5 9.1e-07 28.7 1.5 1.7 1 0 0 1 1 1 1 G-patch domain ubiquitin PF00240.23 CRG85016.1 - 0.0025 17.5 0.0 0.0041 16.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family G-patch_2 PF12656.7 CRG85016.1 - 0.0031 17.6 0.2 0.017 15.2 0.2 2.4 1 0 0 1 1 1 1 G-patch domain Rad60-SLD PF11976.8 CRG85016.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Nop52 PF05997.12 CRG85018.1 - 1.5e-54 185.0 1.2 1.2e-53 182.1 1.2 2.0 1 1 0 1 1 1 1 Nucleolar protein,Nop52 NOT2_3_5 PF04153.18 CRG85018.1 - 0.012 15.7 0.1 0.031 14.4 0.1 1.6 1 0 0 1 1 1 0 NOT2 / NOT3 / NOT5 family RNA_pol_Rpc82 PF05645.13 CRG85018.1 - 0.1 12.3 3.8 0.04 13.7 1.1 1.7 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 NPR3 PF03666.13 CRG85018.1 - 0.14 11.0 2.0 0.17 10.6 2.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NARP1 PF12569.8 CRG85018.1 - 0.16 10.9 3.4 0.23 10.3 3.4 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FancD2 PF14631.6 CRG85018.1 - 0.22 8.9 1.0 0.28 8.5 1.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Spore_coat_CotO PF14153.6 CRG85018.1 - 0.38 10.7 6.2 0.61 10.0 6.2 1.3 1 0 0 1 1 1 0 Spore coat protein CotO CotH PF08757.11 CRG85018.1 - 0.68 9.4 4.9 0.26 10.7 2.5 1.5 2 0 0 2 2 2 0 CotH kinase protein Presenilin PF01080.17 CRG85018.1 - 1 8.0 2.2 1.4 7.6 2.2 1.1 1 0 0 1 1 1 0 Presenilin ORC_WH_C PF18137.1 CRG85018.1 - 2.4 8.3 10.7 26 4.9 0.0 2.5 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal RR_TM4-6 PF06459.12 CRG85018.1 - 2.6 7.8 7.6 4.7 7.0 7.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DAGK_cat PF00781.24 CRG85019.1 - 2.1e-26 92.0 0.0 3.7e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain TIMELESS PF04821.14 CRG85019.1 - 0.19 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Timeless protein Cupin_7 PF12973.7 CRG85020.1 - 2.6e-10 40.1 0.3 4e-10 39.5 0.3 1.3 1 0 0 1 1 1 1 ChrR Cupin-like domain Cupin_2 PF07883.11 CRG85020.1 - 0.00029 20.5 1.2 0.00095 18.8 1.2 1.8 1 1 1 2 2 2 1 Cupin domain AraC_binding PF02311.19 CRG85020.1 - 0.039 13.9 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 AraC-like ligand binding domain ETX_MTX2 PF03318.13 CRG85020.1 - 2.6 7.7 7.1 5.3 6.8 7.1 1.5 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Adaptin_N PF01602.20 CRG85021.1 - 1.5e-97 327.4 9.9 2.4e-97 326.7 9.9 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 CRG85021.1 - 1.7e-58 196.5 0.3 4e-58 195.3 0.3 1.7 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 CRG85021.1 - 1.5e-56 189.9 0.0 4.1e-56 188.4 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 CRG85021.1 - 1.1e-14 54.9 7.1 1.4e-10 41.5 0.1 3.0 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CRG85021.1 - 2e-10 40.9 2.3 2.4e-05 24.6 0.0 4.9 1 1 3 4 4 4 3 HEAT repeats Coatomer_g_Cpla PF16381.5 CRG85021.1 - 0.00017 21.7 0.0 0.00078 19.6 0.0 2.2 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 CRG85021.1 - 0.00019 21.4 0.5 0.69 10.3 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 CRG85021.1 - 0.0032 17.9 0.2 0.61 10.7 0.0 4.3 3 1 1 4 4 4 2 HEAT-like repeat AP4E_app_platf PF14807.6 CRG85021.1 - 0.016 15.5 0.2 0.06 13.7 0.2 2.0 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform DUF5578 PF17741.1 CRG85021.1 - 0.11 12.0 2.7 2.2 7.6 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5578) Arm PF00514.23 CRG85021.1 - 0.16 12.1 3.9 2.9 8.1 0.0 4.6 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Mago_nashi PF02792.14 CRG85023.1 - 5.5e-71 237.3 0.0 6.2e-71 237.1 0.0 1.0 1 0 0 1 1 1 1 Mago nashi protein Vac_ImportDeg PF09783.9 CRG85024.1 - 1.4e-11 44.5 0.0 2.1e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Vacuolar import and degradation protein Sec23_helical PF04815.15 CRG85024.1 - 0.03 14.1 0.2 0.043 13.6 0.2 1.2 1 0 0 1 1 1 0 Sec23/Sec24 helical domain SR-25 PF10500.9 CRG85024.1 - 6.2 6.4 9.3 9.7 5.7 9.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Vac_ImportDeg PF09783.9 CRG85025.1 - 1.1e-33 116.3 1.5 1.2e-33 116.2 1.5 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein Pkinase PF00069.25 CRG85026.1 - 7.9e-66 222.1 0.0 1.8e-65 220.9 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85026.1 - 2.6e-37 128.5 0.0 3.8e-25 88.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CRG85026.1 - 5.6e-05 22.6 0.0 0.0034 16.7 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CRG85026.1 - 0.002 18.1 0.0 0.0075 16.2 0.0 2.0 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG85026.1 - 0.0063 15.3 0.0 0.013 14.3 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 CRG85026.1 - 0.0097 15.0 0.0 0.017 14.2 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 FtsX_ECD PF18075.1 CRG85026.1 - 0.018 15.7 0.0 0.066 13.8 0.0 2.0 1 0 0 1 1 1 0 FtsX extracellular domain DUF4735 PF15882.5 CRG85026.1 - 0.11 11.9 0.3 7 6.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4735) Ammonium_transp PF00909.21 CRG85028.1 - 1.5e-121 405.9 30.7 1.7e-121 405.7 30.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF441 PF04284.13 CRG85028.1 - 0.19 11.7 3.6 0.67 10.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF441) Phage_holin_2_1 PF04971.12 CRG85028.1 - 0.63 10.1 5.0 0.48 10.5 1.0 2.8 2 0 0 2 2 2 0 Bacteriophage P21 holin S Tubulin PF00091.25 CRG85029.1 - 1.1e-67 228.0 0.0 2.3e-67 227.0 0.0 1.6 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CRG85029.1 - 2.2e-41 140.9 0.0 4.4e-41 140.0 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain RRM_1 PF00076.22 CRG85029.1 - 4e-13 49.0 0.0 1.5e-05 24.7 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Misat_Tub_SegII PF10644.9 CRG85029.1 - 9.4e-05 22.7 0.1 0.00036 20.8 0.0 2.1 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 CRG85029.1 - 0.0007 18.9 0.1 0.054 12.7 0.0 2.9 3 0 0 3 3 3 1 Tubulin like Tubulin_3 PF14881.6 CRG85029.1 - 0.009 15.7 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain DUF2236 PF09995.9 CRG85030.1 - 3.4e-09 37.2 1.4 7.5e-09 36.1 1.4 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Cation_ATPase_C PF00689.21 CRG85033.1 - 3.3e-46 157.3 11.0 3.3e-46 157.3 11.0 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CRG85033.1 - 2e-38 131.7 0.8 2e-38 131.7 0.8 2.8 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 CRG85033.1 - 3.1e-23 81.6 0.1 6e-23 80.7 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG85033.1 - 2.1e-17 64.1 0.0 8.8e-17 62.1 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG85033.1 - 1.7e-08 34.0 0.1 9.5e-08 31.6 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CRG85033.1 - 0.00021 21.1 1.3 0.00052 19.8 1.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HD PF01966.22 CRG85035.1 - 3.7e-05 23.9 0.0 6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 HD domain Nup84_Nup100 PF04121.13 CRG85036.1 - 5.5e-149 497.5 13.3 6.8e-149 497.3 13.3 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 LpqV PF17301.2 CRG85036.1 - 0.018 15.3 1.0 0.043 14.1 0.2 2.0 2 0 0 2 2 2 0 Putative lipoprotein LpqV DUF2802 PF10975.8 CRG85036.1 - 0.6 10.3 3.1 0.56 10.4 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) Nop14 PF04147.12 CRG85036.1 - 5.6 5.0 11.0 13 3.8 11.0 1.5 1 0 0 1 1 1 0 Nop14-like family Rad60-SLD PF11976.8 CRG85037.1 - 1.7e-20 72.6 0.1 1.9e-20 72.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CRG85037.1 - 6.4e-11 41.9 0.1 7.2e-11 41.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family TPX2 PF06886.11 CRG85038.1 - 0.23 11.7 14.1 0.47 10.7 14.1 1.5 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Jak1_Phl PF17887.1 CRG85038.1 - 0.29 11.1 3.8 0.13 12.2 1.0 1.7 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Di19_C PF14571.6 CRG85038.1 - 9.3 6.8 9.9 3.8 8.1 1.7 2.2 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Ligase_CoA PF00549.19 CRG85039.1 - 1.4e-34 119.2 0.1 3.9e-16 59.2 0.0 2.6 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.19 CRG85039.1 - 3.1e-18 66.2 0.1 8.2e-18 64.9 0.1 1.7 1 0 0 1 1 1 1 CoA binding domain Succ_CoA_lig PF13607.6 CRG85039.1 - 5.8e-12 45.6 0.0 1.3e-09 38.0 0.0 2.7 3 0 0 3 3 3 2 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CRG85039.1 - 0.0041 17.6 0.3 0.019 15.5 0.1 2.1 2 0 0 2 2 2 1 CoA binding domain 4HBT PF03061.22 CRG85041.1 - 2.2e-11 44.0 0.0 3.8e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily V-ATPase_C PF03223.15 CRG85042.1 - 8.5e-122 407.1 0.0 9.9e-122 406.9 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C APS_kinase PF01583.20 CRG85043.1 - 6.8e-72 240.5 0.0 8.3e-72 240.2 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 CRG85043.1 - 4.6e-06 26.9 0.0 1.1e-05 25.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG85043.1 - 5.7e-05 23.7 0.0 8.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 CRG85043.1 - 0.0042 16.6 0.0 0.0066 15.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 CRG85043.1 - 0.0042 17.5 0.1 0.0066 16.8 0.1 1.2 1 1 0 1 1 1 1 AAA ATPase domain G-alpha PF00503.20 CRG85043.1 - 0.034 13.3 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit NCD2 PF04905.13 CRG85043.1 - 0.092 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) AAA_29 PF13555.6 CRG85043.1 - 0.098 12.4 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CRG85043.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin MFS_1 PF07690.16 CRG85045.1 - 9.9e-26 90.5 28.0 3e-24 85.6 25.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Ycf9 PF01737.17 CRG85045.1 - 0.032 14.1 0.2 0.032 14.1 0.2 2.3 2 0 0 2 2 2 0 YCF9 GCV_T PF01571.21 CRG85047.1 - 5.9e-77 258.5 0.0 7.4e-77 258.2 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 CRG85047.1 - 3.2e-17 62.2 0.1 6.6e-17 61.2 0.1 1.5 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Aa_trans PF01490.18 CRG85048.1 - 3.4e-27 95.2 37.4 3.9e-27 95.0 37.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CBF PF03914.17 CRG85049.1 - 2e-55 187.4 0.3 2e-55 187.4 0.3 3.9 4 0 0 4 4 4 1 CBF/Mak21 family ELM2 PF01448.24 CRG85049.1 - 0.0016 19.1 1.9 0.017 15.9 1.9 2.9 1 0 0 1 1 1 1 ELM2 domain tRNA-synt_2b PF00587.25 CRG85050.1 - 8.6e-29 100.8 0.0 2.6e-28 99.2 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CRG85050.1 - 1.6e-07 31.4 0.0 3.2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain Prefoldin PF02996.17 CRG85052.1 - 4.9e-25 87.8 0.0 6.4e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 CRG85052.1 - 0.0019 18.1 0.3 0.066 13.2 0.1 2.0 2 0 0 2 2 2 1 Prefoldin subunit CLZ PF16526.5 CRG85052.1 - 0.04 14.3 2.3 2 8.9 0.2 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4315 PF14193.6 CRG85052.1 - 0.042 13.8 0.3 0.15 12.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) CC2-LZ PF16516.5 CRG85052.1 - 0.14 12.6 0.4 1.6 9.1 0.1 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Bac_transf PF02397.16 CRG85054.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial sugar transferase AAA PF00004.29 CRG85056.1 - 1.4e-15 57.8 0.0 2.9e-15 56.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 CRG85056.1 - 1.1e-12 47.9 0.9 6.4e-12 45.5 0.6 2.2 1 1 1 2 2 2 1 AAA lid domain AAA_22 PF13401.6 CRG85056.1 - 8.8e-10 39.0 0.0 2.2e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG85056.1 - 4.7e-09 36.8 0.0 3.7e-08 33.9 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain BAH PF01426.18 CRG85056.1 - 7.8e-06 25.8 0.0 2e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 BAH domain AAA_28 PF13521.6 CRG85056.1 - 0.0015 18.8 0.0 0.0071 16.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CRG85056.1 - 0.0037 17.6 0.0 0.0083 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CRG85056.1 - 0.0074 16.5 0.0 0.56 10.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CRG85056.1 - 0.0079 16.1 0.0 0.026 14.4 0.0 1.9 1 1 0 1 1 1 1 NACHT domain AAA_11 PF13086.6 CRG85056.1 - 0.0081 16.0 0.2 0.023 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CRG85056.1 - 0.013 16.0 0.0 0.035 14.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CRG85056.1 - 0.029 13.6 0.0 0.052 12.8 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 CRG85056.1 - 0.09 12.7 0.0 1.4 8.7 0.0 2.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CRG85056.1 - 0.14 12.6 0.0 0.53 10.7 0.0 2.0 2 0 0 2 2 2 0 RNA helicase ssDBP PF17878.1 CRG85056.1 - 0.14 12.4 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Single-stranded DNA-binding protein NTPase_1 PF03266.15 CRG85056.1 - 0.18 11.7 0.1 0.64 9.9 0.0 2.0 2 0 0 2 2 2 0 NTPase WD40 PF00400.32 CRG85057.1 - 1.6e-43 145.8 17.9 5.8e-09 36.4 0.1 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85057.1 - 4.3e-06 26.9 0.6 5 7.5 0.0 5.4 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CRG85057.1 - 0.0027 17.1 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 CRG85057.1 - 0.056 12.1 2.9 18 3.8 0.1 4.2 1 1 4 5 5 5 0 Nucleoporin Nup120/160 Herpes_capsid PF06112.11 CRG85057.1 - 0.13 12.3 3.3 0.24 11.5 3.3 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Ank_2 PF12796.7 CRG85058.1 - 1.1e-41 141.3 7.1 2.2e-14 53.8 0.4 3.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG85058.1 - 8.1e-35 118.8 5.6 6.9e-09 36.1 0.1 4.9 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG85058.1 - 1.4e-31 108.1 0.9 1.1e-08 35.1 0.0 4.6 1 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG85058.1 - 4.7e-28 94.1 1.1 0.00017 21.7 0.0 6.3 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 CRG85058.1 - 2.2e-23 81.6 3.9 5e-05 23.6 0.0 6.3 6 0 0 6 6 6 6 Ankyrin repeat TMF_TATA_bd PF12325.8 CRG85062.1 - 1.7e-40 137.8 11.6 1.7e-40 137.8 11.6 7.3 3 2 3 6 6 6 1 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 CRG85062.1 - 1.1e-16 60.6 17.2 1.1e-16 60.6 17.2 10.6 7 4 2 10 10 10 2 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 CRG85062.1 - 9.3e-06 26.0 5.0 9.3e-06 26.0 5.0 6.0 2 1 3 5 5 5 1 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 CRG85062.1 - 1.2 9.7 16.1 1.8 9.1 0.6 5.7 4 2 2 6 6 6 0 Nucleopolyhedrovirus P10 protein DASH_Duo1 PF08651.10 CRG85062.1 - 2.6 7.9 9.3 0.17 11.6 0.5 3.8 4 0 0 4 4 4 0 DASH complex subunit Duo1 V-ATPase_H_N PF03224.14 CRG85063.1 - 1.2e-81 274.4 0.1 1.8e-81 273.9 0.1 1.3 1 0 0 1 1 1 1 V-ATPase subunit H Fungal_trans_2 PF11951.8 CRG85063.1 - 2.2e-59 201.2 0.1 2.2e-59 201.2 0.1 1.8 3 0 0 3 3 3 1 Fungal specific transcription factor domain V-ATPase_H_C PF11698.8 CRG85063.1 - 5e-36 123.4 0.0 1.7e-35 121.7 0.0 2.0 2 0 0 2 2 2 1 V-ATPase subunit H MatP_C PF17414.2 CRG85064.1 - 0.19 11.9 7.6 0.082 13.1 1.6 3.4 3 0 0 3 3 3 0 MatP C-terminal ribbon-helix-helix domain DUF5133 PF17196.4 CRG85064.1 - 0.49 10.6 3.4 8.8 6.6 0.1 3.6 2 0 0 2 2 2 0 Protein of unknown function (DUF5133) ALS2CR8 PF15299.6 CRG85064.1 - 1.9 8.4 12.7 12 5.7 12.7 2.2 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 MCC-bdg_PDZ PF10506.9 CRG85064.1 - 1.9 8.6 11.9 1.1 9.3 0.9 4.2 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Apq12 PF12716.7 CRG85065.1 - 3.6e-17 62.0 15.6 6.6e-17 61.2 15.6 1.5 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis DUF3810 PF12725.7 CRG85065.1 - 2.6 7.3 7.7 3.7 6.8 7.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) ATP_bind_1 PF03029.17 CRG85066.1 - 8.6e-76 254.9 0.0 1.2e-75 254.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 CRG85066.1 - 0.00018 21.5 0.0 0.00037 20.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG85066.1 - 0.00042 20.7 0.0 0.0032 17.9 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CRG85066.1 - 0.00064 20.2 0.0 0.0016 18.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CLP1_P PF16575.5 CRG85066.1 - 0.00066 19.5 0.0 0.0014 18.5 0.0 1.5 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop T2SSE PF00437.20 CRG85066.1 - 0.0012 18.0 0.0 0.0022 17.1 0.0 1.5 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 CRG85066.1 - 0.0023 18.2 0.0 0.0059 16.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG85066.1 - 0.0034 17.7 0.0 0.022 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CRG85066.1 - 0.0039 16.9 0.0 0.0071 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG85066.1 - 0.0041 17.7 0.0 0.008 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CRG85066.1 - 0.0056 16.2 0.0 0.013 15.0 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region RNA_helicase PF00910.22 CRG85066.1 - 0.0063 16.9 0.0 0.013 15.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 CRG85066.1 - 0.0071 16.9 0.0 0.019 15.5 0.0 1.7 2 0 0 2 2 1 1 ABC transporter KAP_NTPase PF07693.14 CRG85066.1 - 0.0096 15.2 0.0 0.021 14.1 0.0 1.7 1 1 0 1 1 1 1 KAP family P-loop domain AAA_30 PF13604.6 CRG85066.1 - 0.011 15.4 0.0 0.036 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CRG85066.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 CRG85066.1 - 0.018 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 CRG85066.1 - 0.018 15.0 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 CRG85066.1 - 0.019 14.8 0.0 0.18 11.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 CRG85066.1 - 0.023 14.8 0.0 0.038 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 CRG85066.1 - 0.024 14.5 0.0 4.9 7.0 0.1 2.3 1 1 1 2 2 2 0 AAA domain NTPase_1 PF03266.15 CRG85066.1 - 0.026 14.4 0.1 0.053 13.4 0.0 1.5 2 0 0 2 2 1 0 NTPase Sigma54_activat PF00158.26 CRG85066.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Septin PF00735.18 CRG85066.1 - 0.038 13.3 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Septin MMR_HSR1 PF01926.23 CRG85066.1 - 0.039 14.0 0.0 0.15 12.1 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CRG85066.1 - 0.04 13.7 0.0 0.088 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 CRG85066.1 - 0.047 13.3 0.0 0.091 12.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase PF06745.13 CRG85066.1 - 0.049 13.0 0.0 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.22 CRG85066.1 - 0.051 12.8 0.0 0.077 12.2 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain cobW PF02492.19 CRG85066.1 - 0.051 13.2 0.1 0.23 11.0 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Thymidylate_kin PF02223.17 CRG85066.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase GTP_EFTU PF00009.27 CRG85066.1 - 0.092 12.3 0.0 4.5 6.8 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 CRG85066.1 - 0.095 12.4 0.1 0.37 10.5 0.0 1.9 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 CRG85066.1 - 0.13 12.6 0.0 0.35 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CRG85066.1 - 0.15 11.8 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein CbiA PF01656.23 CRG85066.1 - 0.16 12.1 0.0 0.17 11.9 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 CRG85066.1 - 0.16 12.0 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 CRG85066.1 - 0.18 11.1 0.0 0.35 10.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin S-AdoMet_synt_C PF02773.16 CRG85068.1 - 1.4e-66 222.7 0.3 4.2e-66 221.2 0.1 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 CRG85068.1 - 1.1e-44 151.1 0.5 2.3e-44 150.1 0.1 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 CRG85068.1 - 2e-43 147.5 0.0 3.8e-43 146.5 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 CRG85068.1 - 0.16 10.8 0.1 1.3 7.7 0.1 2.0 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) SLD3 PF08639.10 CRG85069.1 - 3.3e-161 537.7 10.7 3.3e-161 537.7 10.7 1.5 2 0 0 2 2 2 1 DNA replication regulator SLD3 CRC_subunit PF08624.10 CRG85070.1 - 2.3e-52 177.0 0.0 3.3e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit AT_hook PF02178.19 CRG85070.1 - 7 6.9 9.0 22 5.4 9.0 1.9 1 0 0 1 1 1 0 AT hook motif Homeodomain PF00046.29 CRG85071.1 - 5.3e-16 58.2 1.8 1.2e-15 57.1 1.8 1.6 1 0 0 1 1 1 1 Homeodomain His_Phos_1 PF00300.22 CRG85071.1 - 3.2e-07 30.2 0.1 8.7e-07 28.8 0.1 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Homeobox_KN PF05920.11 CRG85071.1 - 3.8e-05 23.5 1.0 0.00012 21.9 1.0 1.9 1 0 0 1 1 1 1 Homeobox KN domain DUF4638 PF15472.6 CRG85071.1 - 1.1 9.0 7.1 1.9 8.2 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) HAD_2 PF13419.6 CRG85073.1 - 1.2e-24 87.3 0.0 1.8e-24 86.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG85073.1 - 8e-14 52.4 0.2 9.1e-09 35.9 0.0 2.9 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 CRG85073.1 - 1.6e-08 35.2 0.0 2.3e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 CRG85073.1 - 0.00034 20.7 0.0 0.063 13.4 0.0 2.6 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG85073.1 - 0.00064 19.7 0.0 0.0015 18.5 0.0 1.7 2 0 0 2 2 2 1 HAD-hyrolase-like IF2_N PF04760.15 CRG85073.1 - 0.03 14.1 0.0 0.12 12.3 0.0 2.0 3 0 0 3 3 3 0 Translation initiation factor IF-2, N-terminal region GN3L_Grn1 PF08701.11 CRG85074.1 - 2.2e-24 85.4 14.2 6.5e-24 83.8 14.2 1.9 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 CRG85074.1 - 6.6e-18 64.9 0.4 1.4e-13 50.9 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG85074.1 - 1.8e-07 31.2 0.1 1.9e-06 27.9 0.1 2.1 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 CRG85074.1 - 2.6e-05 23.8 0.0 0.00017 21.2 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CRG85074.1 - 3.5e-05 23.9 3.8 0.5 10.4 0.1 3.6 3 1 1 4 4 4 2 Dynamin family GTP_EFTU PF00009.27 CRG85074.1 - 7.4e-05 22.4 0.0 0.27 10.8 0.0 2.6 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 CRG85074.1 - 0.0066 15.5 1.8 0.0089 15.0 0.0 1.9 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 CRG85074.1 - 0.0079 15.5 0.1 0.18 11.1 0.1 2.2 2 0 0 2 2 2 1 AIG1 family RRN3 PF05327.11 CRG85074.1 - 0.042 12.4 7.2 0.056 12.0 7.2 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Roc PF08477.13 CRG85074.1 - 0.061 13.5 0.0 17 5.7 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 CRG85074.1 - 0.12 12.9 0.0 0.12 12.9 0.0 2.7 3 1 1 4 4 3 0 AAA domain AAA_16 PF13191.6 CRG85074.1 - 0.47 10.8 0.0 0.47 10.8 0.0 3.0 2 1 0 2 2 1 0 AAA ATPase domain Nop14 PF04147.12 CRG85074.1 - 2.7 6.1 25.9 4.6 5.3 25.9 1.3 1 0 0 1 1 1 0 Nop14-like family CBFD_NFYB_HMF PF00808.23 CRG85075.1 - 4.9e-06 26.7 0.0 9.3e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Peptidase_M15 PF01427.17 CRG85075.1 - 0.13 12.0 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 D-ala-D-ala dipeptidase Histone PF00125.24 CRG85075.1 - 0.14 12.5 0.0 0.14 12.5 0.0 2.5 2 1 1 3 3 3 0 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 CRG85075.1 - 1.8 8.9 0.0 1.8 8.9 0.0 3.0 3 1 0 3 3 3 0 CENP-S associating Centromere protein X CDC27 PF09507.10 CRG85075.1 - 4.2 6.7 25.4 5.7 6.2 25.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SIR2 PF02146.17 CRG85076.1 - 4.7e-30 104.8 0.0 1.3e-29 103.4 0.0 1.8 1 1 0 1 1 1 1 Sir2 family ACP_PD PF04336.12 CRG85076.1 - 0.017 15.5 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase Zn-ribbon_8 PF09723.10 CRG85076.1 - 0.055 13.6 1.4 0.16 12.1 1.4 1.8 1 0 0 1 1 1 0 Zinc ribbon domain Med16 PF11635.8 CRG85078.1 - 2.1e-190 634.4 0.0 2.5e-190 634.2 0.0 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 CRG85078.1 - 0.1 12.9 0.0 4 7.8 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ribosomal_L29 PF00831.23 CRG85079.1 - 1.4e-18 66.6 0.4 1.4e-18 66.6 0.4 1.9 2 0 0 2 2 2 1 Ribosomal L29 protein Cortex-I_coil PF09304.10 CRG85079.1 - 0.073 13.3 2.2 0.13 12.4 1.2 1.8 2 0 0 2 2 2 0 Cortexillin I, coiled coil CorA PF01544.18 CRG85079.1 - 0.11 11.8 2.1 0.14 11.4 2.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein V-SNARE_C PF12352.8 CRG85080.1 - 1.4e-12 47.7 0.1 1.4e-12 47.7 0.1 2.6 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec34 PF04136.15 CRG85080.1 - 0.048 13.5 4.4 1 9.2 2.4 2.4 2 1 0 2 2 2 0 Sec34-like family Syntaxin-6_N PF09177.11 CRG85080.1 - 0.064 13.8 5.3 0.14 12.7 4.8 1.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal GOLGA2L5 PF15070.6 CRG85080.1 - 0.066 11.9 8.4 0.092 11.4 8.4 1.1 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 STAT_alpha PF01017.20 CRG85080.1 - 0.092 12.6 6.0 0.24 11.3 5.6 1.9 2 1 0 2 2 2 0 STAT protein, all-alpha domain Syntaxin_2 PF14523.6 CRG85080.1 - 0.34 11.3 6.6 3.8 7.9 6.3 2.5 1 1 1 2 2 2 0 Syntaxin-like protein YlqD PF11068.8 CRG85080.1 - 1.6 9.1 6.0 1.5 9.2 4.7 1.5 1 1 1 2 2 2 0 YlqD protein FUSC PF04632.12 CRG85080.1 - 3.1 6.2 6.2 4.5 5.7 6.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family CENP-H PF05837.12 CRG85080.1 - 3.7 8.0 7.6 4.5 7.7 6.5 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Snapin_Pallidin PF14712.6 CRG85080.1 - 7.8 7.0 10.6 1.4 9.3 6.4 2.0 2 0 0 2 2 2 0 Snapin/Pallidin FliJ PF02050.16 CRG85080.1 - 7.9 6.7 11.1 1.3 9.3 4.8 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein ATP-synt_10 PF05176.14 CRG85082.1 - 1.3e-77 260.5 0.0 1.6e-77 260.2 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein GAF_2 PF13185.6 CRG85082.1 - 0.054 13.8 0.0 2.5 8.4 0.0 2.2 2 0 0 2 2 2 0 GAF domain adh_short PF00106.25 CRG85083.1 - 3.2e-38 131.2 0.1 5.9e-38 130.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85083.1 - 5.7e-29 101.3 0.0 9e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85083.1 - 7.8e-10 39.0 0.1 1.3e-09 38.2 0.1 1.4 1 0 0 1 1 1 1 KR domain Zn_clus PF00172.18 CRG85083.1 - 1.4e-08 34.7 8.7 2.6e-08 33.8 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1776 PF08643.10 CRG85083.1 - 1.4e-07 31.2 0.0 3.4e-05 23.4 0.0 2.2 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CRG85083.1 - 2.8e-05 24.1 0.1 5.9e-05 23.0 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Fungal_trans PF04082.18 CRG85083.1 - 3.8e-05 22.8 0.0 6.3e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 CRG85083.1 - 0.005 16.4 0.1 0.0082 15.7 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CRG85083.1 - 0.0094 15.4 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 CRG85083.1 - 0.02 15.5 0.0 0.083 13.5 0.0 2.0 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DIOX_N PF14226.6 CRG85085.1 - 5.4e-34 117.5 0.0 8.1e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG85085.1 - 2.6e-20 72.8 0.0 4.9e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FAA_hydrolase PF01557.18 CRG85087.1 - 4.5e-63 212.8 0.0 7.4e-63 212.1 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_1 PF00561.20 CRG85087.1 - 1.6e-25 90.2 0.0 8.3e-25 87.9 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG85087.1 - 1.3e-18 67.2 0.0 2.2e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG85087.1 - 7e-18 66.0 3.6 1.7e-17 64.8 3.6 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Amidohydro_1 PF01979.20 CRG85087.1 - 2.7e-16 59.8 0.6 4.2e-16 59.2 0.6 1.3 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG85087.1 - 2e-08 34.1 2.7 1.1e-05 25.1 0.3 3.8 2 1 0 2 2 2 2 Amidohydrolase family Abhydrolase_4 PF08386.10 CRG85087.1 - 0.0013 18.9 0.0 0.0059 16.7 0.0 2.1 2 0 0 2 2 2 1 TAP-like protein DUF2437 PF10370.9 CRG85087.1 - 0.0078 17.1 0.0 0.033 15.1 0.0 2.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2437) UPF0227 PF05728.12 CRG85087.1 - 0.02 14.9 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Abhydrolase_2 PF02230.16 CRG85087.1 - 0.13 12.1 0.0 7.1 6.4 0.0 2.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 CRG85087.1 - 0.14 12.3 0.1 0.26 11.4 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_9 PF10081.9 CRG85089.1 - 0.14 11.2 0.1 0.31 10.1 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta-hydrolase family MFS_1 PF07690.16 CRG85091.1 - 3.8e-22 78.7 36.1 3.8e-22 78.7 36.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MMPL PF03176.15 CRG85091.1 - 7.8 5.3 6.9 0.31 9.9 0.3 1.8 2 0 0 2 2 2 0 MMPL family DNA_pol_B_palm PF14792.6 CRG85094.1 - 2.4e-34 118.0 0.0 5e-34 116.9 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 CRG85094.1 - 9.8e-25 86.5 0.0 7.5e-24 83.7 0.0 2.3 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 CRG85094.1 - 3.2e-19 68.5 0.3 1.1e-18 66.7 0.3 2.0 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 CRG85094.1 - 1.8e-18 66.6 0.8 3.8e-18 65.6 0.8 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain BRCT PF00533.26 CRG85094.1 - 0.00097 19.5 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CRG85094.1 - 0.033 14.6 0.0 0.066 13.6 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain NTP_transf_2 PF01909.23 CRG85094.1 - 0.12 12.6 0.1 0.31 11.4 0.1 1.6 1 0 0 1 1 1 0 Nucleotidyltransferase domain Zn_clus PF00172.18 CRG85095.1 - 0.031 14.4 7.3 0.079 13.1 7.3 1.7 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-BED PF02892.15 CRG85095.1 - 0.044 13.8 0.1 0.092 12.8 0.1 1.5 1 0 0 1 1 1 0 BED zinc finger PH_12 PF16457.5 CRG85095.1 - 0.12 12.9 0.1 2.2 8.8 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Tropomyosin PF00261.20 CRG85097.1 - 0.0043 16.5 0.3 0.84 9.0 0.1 2.3 2 0 0 2 2 2 2 Tropomyosin CPL PF08144.11 CRG85098.1 - 1.1e-31 110.1 0.0 3.4e-29 102.0 0.0 3.7 3 0 0 3 3 3 1 CPL (NUC119) domain SCHIP-1 PF10148.9 CRG85098.1 - 0.6 9.7 8.1 0.068 12.8 3.2 1.9 1 1 1 2 2 2 0 Schwannomin-interacting protein 1 DUF2157 PF09925.9 CRG85101.1 - 0.021 14.6 0.2 0.021 14.6 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) GspL_C PF12693.7 CRG85101.1 - 0.082 12.7 1.4 0.14 12.0 1.4 1.3 1 0 0 1 1 1 0 GspL periplasmic domain LapA_dom PF06305.11 CRG85101.1 - 0.15 11.9 0.2 0.22 11.4 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SCIMP PF15050.6 CRG85101.1 - 0.32 11.4 2.1 0.97 9.9 0.6 2.0 2 0 0 2 2 2 0 SCIMP protein Nup160 PF11715.8 CRG85102.1 - 1.6e-154 515.5 3.4 2.6e-154 514.8 3.4 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Rad51 PF08423.11 CRG85102.1 - 1.1e-127 424.7 0.0 1.5e-127 424.2 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 CRG85102.1 - 1.7e-09 37.5 0.4 4.1e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain RecA PF00154.21 CRG85102.1 - 2.9e-08 33.5 0.0 4.9e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 CRG85102.1 - 2e-05 25.1 0.6 6.2e-05 23.5 0.6 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 CRG85102.1 - 0.0003 20.2 0.2 0.00095 18.6 0.2 1.9 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 CRG85102.1 - 0.045 13.1 0.1 0.17 11.2 0.0 1.8 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain MFS_1 PF07690.16 CRG85103.1 - 8.5e-37 126.9 34.1 8.5e-37 126.9 34.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_5_2 PF16079.5 CRG85103.1 - 0.67 10.3 7.3 5.2 7.5 0.6 3.2 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V DUF3808 PF10300.9 CRG85104.1 - 1e-149 499.4 0.0 1.2e-149 499.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) YscO PF07321.12 CRG85104.1 - 0.001 19.1 0.1 0.001 19.1 0.1 3.1 4 0 0 4 4 4 1 Type III secretion protein YscO DSS1_SEM1 PF05160.13 CRG85105.1 - 2.7e-23 81.8 17.2 3.6e-23 81.4 17.2 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family baeRF_family12 PF18856.1 CRG85105.1 - 0.036 14.6 2.1 0.039 14.5 2.1 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Strep_pep PF14404.6 CRG85105.1 - 0.081 13.2 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Ribosomally synthesized peptide in Streptomyces species Nuc_deoxyri_tr2 PF15891.5 CRG85105.1 - 4 7.8 6.4 1.9 8.9 4.4 1.5 1 1 1 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like PGK PF00162.19 CRG85106.1 - 4e-145 483.5 0.5 4.5e-145 483.3 0.5 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 CRG85106.1 - 0.0043 17.0 0.0 0.23 11.5 0.0 3.2 3 1 0 3 3 3 1 PA domain DUF3530 PF12048.8 CRG85106.1 - 0.055 12.9 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Trs65 PF12735.7 CRG85107.1 - 2.8e-97 326.0 0.0 3.8e-97 325.5 0.0 1.2 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Mpv17_PMP22 PF04117.12 CRG85107.1 - 4.3e-19 68.5 0.1 9.4e-19 67.4 0.1 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family FF PF01846.19 CRG85108.1 - 3.3e-52 174.5 19.4 1.7e-15 56.9 0.3 7.0 6 1 0 6 6 6 6 FF domain WW PF00397.26 CRG85108.1 - 8e-16 57.8 12.6 6.8e-08 32.5 0.4 2.7 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 CRG85108.1 - 0.00026 21.6 10.4 1 10.1 0.1 4.8 2 1 2 4 4 4 2 p190-A and -B Rho GAPs FF domain Glyco_hyd_101C PF17451.2 CRG85108.1 - 0.34 11.2 7.1 6.3 7.1 2.3 2.7 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Cytochrom_B562 PF07361.11 CRG85108.1 - 3.1 8.5 7.2 0.74 10.5 0.2 3.1 3 0 0 3 3 3 0 Cytochrome b562 SNF2_N PF00176.23 CRG85109.1 - 3.6e-56 190.4 0.0 5.7e-56 189.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 CRG85109.1 - 3.9e-21 74.7 3.0 2.1e-13 49.9 0.6 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 CRG85109.1 - 2e-19 70.0 0.0 4.4e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 CRG85109.1 - 1.5e-10 41.3 0.1 6.3e-10 39.4 0.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4208) ResIII PF04851.15 CRG85109.1 - 5.7e-07 29.7 0.0 0.00012 22.1 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 CRG85109.1 - 7.3e-07 29.5 15.8 8.9e-06 26.0 0.3 4.1 2 2 1 4 4 4 2 Chromodomain helicase DNA-binding domain 1 HDA2-3 PF11496.8 CRG85109.1 - 1.6e-06 27.5 0.0 5.2e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 CHDCT2 PF08074.11 CRG85109.1 - 0.034 14.3 0.3 0.15 12.3 0.0 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain CDH1_2_SANT_HL1 PF18375.1 CRG85109.1 - 3.9 8.2 8.3 0.18 12.5 0.9 2.7 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 zf-H2C2_2 PF13465.6 CRG85110.1 - 8.6e-08 32.3 7.2 2.3e-06 27.7 0.6 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_6 PF13912.6 CRG85110.1 - 5.7e-07 29.4 1.5 0.01 15.8 0.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG85110.1 - 7.1e-06 26.2 0.3 7.1e-06 26.2 0.3 3.8 3 1 0 3 3 3 1 Zinc finger, C2H2 type FOXP-CC PF16159.5 CRG85110.1 - 7.6e-06 26.5 4.9 0.16 12.6 1.3 3.3 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 CRG85110.1 - 0.0005 20.7 7.4 0.0049 17.6 0.2 3.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CRG85110.1 - 0.16 11.8 0.6 0.53 10.1 0.0 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 CRG85110.1 - 1.7 9.0 4.3 2.6 8.5 0.2 2.9 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Zap1_zf2 PF18217.1 CRG85110.1 - 1.9 8.5 11.4 8.5 6.5 4.1 2.7 2 1 0 2 2 2 0 Zap1 zinc finger 2 zf_ZIC PF18366.1 CRG85110.1 - 7.3 6.8 9.8 19 5.4 2.9 3.6 3 1 0 3 3 3 0 Zic proteins zinc finger domain Aldo_ket_red PF00248.21 CRG85112.1 - 2.5e-62 210.7 0.0 2.9e-62 210.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Nop14 PF04147.12 CRG85113.1 - 0.0013 17.1 2.4 0.0014 17.0 2.4 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2076 PF09849.9 CRG85113.1 - 0.15 12.1 3.5 0.18 11.8 3.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Cnd2 PF05786.14 CRG85113.1 - 0.16 10.6 8.1 0.18 10.5 8.1 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 RXT2_N PF08595.11 CRG85113.1 - 0.72 9.9 5.1 0.91 9.5 5.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 CRG85113.1 - 1 9.8 16.4 1.8 9.0 16.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GCIP PF13324.6 CRG85113.1 - 1.2 8.7 6.3 1.6 8.3 6.3 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 CRG85113.1 - 1.8 7.8 19.0 2.4 7.4 19.0 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CRG85113.1 - 2.5 6.1 15.3 2.9 5.9 15.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 CRG85113.1 - 4.7 6.5 10.9 5.5 6.3 10.9 1.0 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 CRG85113.1 - 4.9 6.2 19.6 6.6 5.8 19.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 CRG85113.1 - 5.2 5.2 9.6 6.2 5.0 9.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.13 CRG85113.1 - 6.1 6.7 8.9 8.1 6.3 8.9 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Fungal_trans PF04082.18 CRG85114.1 - 6e-05 22.2 1.0 0.00028 20.0 0.1 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain N-glycanase_C PF09113.10 CRG85114.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Peptide-N-glycosidase F, C terminal AdoHcyase PF05221.17 CRG85115.1 - 3.5e-128 426.9 0.0 1.1e-73 248.0 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 CRG85115.1 - 7.6e-83 276.4 2.0 1.2e-82 275.8 2.0 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 CRG85115.1 - 1.7e-06 27.5 0.1 3.4e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CRG85115.1 - 0.0033 17.0 0.4 0.0061 16.1 0.4 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 CRG85115.1 - 0.0082 15.9 0.1 0.014 15.2 0.1 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 CRG85115.1 - 0.021 15.1 0.1 0.043 14.1 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Urocanase PF01175.18 CRG85115.1 - 0.096 12.3 0.3 0.18 11.4 0.3 1.4 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Nop PF01798.18 CRG85118.1 - 1.1e-62 211.5 0.1 1.7e-62 210.9 0.1 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 CRG85118.1 - 5.2e-45 153.3 0.7 1.3e-44 152.0 0.7 1.7 1 0 0 1 1 1 1 Prp31 C terminal domain HAT PF02184.16 CRG85119.1 - 7.4e-28 96.2 76.7 3e-13 49.5 4.1 14.3 15 0 0 15 15 15 6 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 CRG85119.1 - 3.3e-20 71.0 23.5 0.015 16.0 0.3 11.3 7 3 6 13 13 12 7 Tetratricopeptide repeat TPR_19 PF14559.6 CRG85119.1 - 6.6e-18 65.0 0.0 5.2e-05 23.7 0.0 7.6 7 0 0 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 CRG85119.1 - 8.7e-14 52.2 25.6 0.0006 19.9 0.7 6.8 2 1 3 6 6 6 5 Suppressor of forked protein (Suf) TPR_17 PF13431.6 CRG85119.1 - 6.7e-11 41.8 0.4 0.08 13.4 0.0 6.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG85119.1 - 0.00012 22.0 9.4 10 6.6 0.1 8.0 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 CRG85119.1 - 0.00093 19.7 20.4 16 6.4 0.1 8.2 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_2 PF07719.17 CRG85119.1 - 0.037 14.1 20.2 1.1 9.5 0.0 7.9 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG85119.1 - 0.099 13.3 12.1 6.6 7.5 0.0 6.4 8 1 1 9 9 8 0 Tetratricopeptide repeat NRDE-2 PF08424.10 CRG85119.1 - 0.1 11.7 32.8 0.16 11.1 3.4 6.2 3 3 3 6 6 6 0 NRDE-2, necessary for RNA interference TPR_12 PF13424.6 CRG85119.1 - 0.11 12.8 16.6 6.6 7.1 0.0 7.2 8 1 1 9 9 8 0 Tetratricopeptide repeat TPR_1 PF00515.28 CRG85119.1 - 0.14 12.0 6.5 38 4.3 0.2 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat ECSIT PF06239.11 CRG85119.1 - 0.16 11.1 6.2 0.17 11.0 0.3 2.6 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway DUF3391 PF11871.8 CRG85119.1 - 0.61 10.6 12.6 13 6.3 0.0 4.2 3 1 0 3 3 3 0 Domain of unknown function (DUF3391) U3_assoc_6 PF08640.11 CRG85119.1 - 0.98 9.5 29.8 0.032 14.3 1.9 7.0 6 2 2 8 8 8 0 U3 small nucleolar RNA-associated protein 6 Fis1_TPR_C PF14853.6 CRG85119.1 - 1.1 9.4 10.7 11 6.2 0.2 5.7 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Kelch_6 PF13964.6 CRG85120.1 - 2e-06 27.9 3.3 0.3 11.4 0.0 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 CRG85120.1 - 9.3e-06 25.5 1.8 0.38 10.8 0.1 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 CRG85120.1 - 0.00041 19.9 0.9 0.13 11.8 0.1 3.5 3 0 0 3 3 3 1 Kelch motif TMEM154 PF15102.6 CRG85120.1 - 0.00046 20.1 0.0 0.0013 18.7 0.0 1.7 1 0 0 1 1 1 1 TMEM154 protein family Kelch_4 PF13418.6 CRG85120.1 - 0.0013 18.7 0.1 3.4 7.7 0.0 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Podoplanin PF05808.11 CRG85120.1 - 0.03 14.4 2.8 0.14 12.2 2.8 2.1 1 0 0 1 1 1 0 Podoplanin RIFIN PF02009.16 CRG85120.1 - 0.16 11.9 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 Rifin Alpha_GJ PF03229.13 CRG85120.1 - 0.81 10.2 21.5 2.1 8.9 10.1 3.7 3 0 0 3 3 3 0 Alphavirus glycoprotein J Rax2 PF12768.7 CRG85120.1 - 5.9 6.3 8.4 7.5 5.9 0.5 3.7 3 1 1 4 4 4 0 Cortical protein marker for cell polarity MGC-24 PF05283.11 CRG85120.1 - 7.3 7.0 9.5 0.29 11.6 1.4 2.6 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MFS_1 PF07690.16 CRG85121.1 - 6e-21 74.7 13.6 6e-21 74.7 13.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG85121.1 - 1.3e-05 24.3 7.2 2e-05 23.6 7.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter SecE PF00584.20 CRG85121.1 - 0.065 13.2 0.0 0.065 13.2 0.0 2.9 4 0 0 4 4 4 0 SecE/Sec61-gamma subunits of protein translocation complex Aldo_ket_red PF00248.21 CRG85122.1 - 2.8e-38 131.8 0.0 2.5e-25 89.3 0.0 3.0 2 1 0 2 2 2 2 Aldo/keto reductase family Clenterotox PF03505.14 CRG85122.1 - 0.058 13.0 0.0 0.092 12.3 0.0 1.4 1 0 0 1 1 1 0 Clostridium enterotoxin Dak1 PF02733.17 CRG85123.1 - 1.1e-106 356.2 1.7 1.1e-106 356.2 1.7 1.7 2 0 0 2 2 2 1 Dak1 domain Dak2 PF02734.17 CRG85123.1 - 7.5e-42 143.2 0.4 7.5e-42 143.2 0.4 2.2 3 0 0 3 3 3 1 DAK2 domain NAD_binding_4 PF07993.12 CRG85128.1 - 1.2e-37 129.5 0.0 1.7e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG85128.1 - 9.1e-27 93.7 0.0 1.6e-26 92.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CRG85128.1 - 7.8e-12 45.2 0.0 2e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG85128.1 - 0.00013 22.3 0.1 0.00026 21.3 0.1 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CRG85128.1 - 0.071 13.0 0.0 0.24 11.3 0.0 1.9 1 1 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 CRG85128.1 - 0.091 12.1 0.0 0.74 9.2 0.0 2.2 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase MFS_1 PF07690.16 CRG85130.1 - 8e-26 90.8 22.9 1.2e-25 90.2 22.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Saf_2TM PF18303.1 CRG85130.1 - 0.44 10.1 0.0 0.44 10.1 0.0 2.7 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain zf-C2H2 PF00096.26 CRG85131.1 - 2.7e-06 27.5 11.2 7.2e-05 23.0 3.0 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG85131.1 - 1.8e-05 24.9 2.5 1.8e-05 24.9 2.5 3.5 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG85131.1 - 0.0015 19.2 9.4 0.0016 19.1 1.4 2.9 3 0 0 3 3 2 1 C2H2-type zinc finger zf-met PF12874.7 CRG85131.1 - 0.002 18.5 1.1 0.002 18.5 1.1 2.9 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-Di19 PF05605.12 CRG85131.1 - 0.0047 17.2 4.4 0.011 16.0 4.4 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding BolA PF01722.18 CRG85131.1 - 0.025 14.9 1.0 0.053 13.8 1.0 1.5 1 0 0 1 1 1 0 BolA-like protein DUF2225 PF09986.9 CRG85131.1 - 0.026 14.3 0.4 0.05 13.3 0.4 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_jaz PF12171.8 CRG85131.1 - 0.066 13.5 0.4 0.27 11.6 0.4 2.0 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CRG85131.1 - 0.12 12.4 0.6 0.12 12.4 0.6 2.5 3 0 0 3 3 3 0 C2H2-type zinc finger FYDLN_acid PF09538.10 CRG85131.1 - 0.15 12.7 3.1 0.15 12.7 1.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CTU2 PF10288.9 CRG85131.1 - 0.58 10.4 6.5 1.3 9.3 6.4 1.6 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Spem1 PF15670.5 CRG85131.1 - 1.1 8.8 6.6 2.4 7.7 6.6 1.5 1 0 0 1 1 1 0 Spermatid maturation protein 1 UPF0261 PF06792.11 CRG85132.1 - 3.3e-165 549.9 0.3 3.7e-165 549.8 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) PNPase_C PF12111.8 CRG85132.1 - 0.12 11.8 0.2 0.36 10.3 0.2 1.8 1 0 0 1 1 1 0 Polyribonucleotide phosphorylase C terminal PEP_hydrolase PF09370.10 CRG85133.1 - 1.4e-135 450.7 0.4 1.6e-135 450.5 0.4 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 CRG85133.1 - 0.0015 18.0 0.5 0.002 17.6 0.1 1.4 2 0 0 2 2 2 1 Nitronate monooxygenase MFS_1 PF07690.16 CRG85135.1 - 9.9e-40 136.5 29.9 1.5e-39 135.9 29.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 CRG85135.1 - 0.00087 17.7 8.5 0.00087 17.7 8.5 2.8 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family CMD PF02627.20 CRG85136.1 - 1.3e-14 54.0 0.1 4.3e-06 26.7 0.0 2.5 2 0 0 2 2 2 2 Carboxymuconolactone decarboxylase family Lactamase_B PF00753.27 CRG85136.1 - 1.8e-10 41.1 2.4 7e-10 39.2 2.4 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG85136.1 - 0.0091 15.5 0.1 0.033 13.7 0.0 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain NAD_binding_2 PF03446.15 CRG85137.1 - 9.7e-33 113.6 0.0 1.3e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG85137.1 - 3.1e-21 75.8 0.0 5.1e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CRG85137.1 - 0.0027 18.3 0.0 0.005 17.4 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CRG85137.1 - 0.032 14.3 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase OCD_Mu_crystall PF02423.15 CRG85137.1 - 0.13 11.2 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family NAD_binding_4 PF07993.12 CRG85138.1 - 6.1e-26 91.1 0.0 9.3e-26 90.5 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG85138.1 - 2.3e-24 85.8 0.0 3.4e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CRG85138.1 - 7e-12 45.3 0.0 1.2e-11 44.6 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG85138.1 - 4.8e-08 33.2 0.5 2.3e-07 31.1 0.1 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site KR PF08659.10 CRG85138.1 - 0.053 13.4 0.1 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 KR domain Polysacc_synt_2 PF02719.15 CRG85138.1 - 0.13 11.4 0.3 1.1 8.3 0.1 2.7 4 0 0 4 4 4 0 Polysaccharide biosynthesis protein PcrB PF01884.17 CRG85138.1 - 0.18 11.2 0.0 0.36 10.3 0.0 1.4 1 0 0 1 1 1 0 PcrB family CMD PF02627.20 CRG85139.1 - 3.2e-21 75.2 0.0 4.8e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family TFX_C PF14601.6 CRG85139.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term Fungal_trans PF04082.18 CRG85140.1 - 2.1e-10 40.1 2.3 2.1e-10 40.1 2.3 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain NAD_binding_11 PF14833.6 CRG85141.1 - 2.1e-22 79.6 0.0 4.3e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 CRG85141.1 - 2.1e-21 76.7 0.7 4.3e-21 75.7 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_N PF08240.12 CRG85141.1 - 2.9e-17 62.5 1.4 1e-16 60.8 0.3 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG85141.1 - 2.5e-14 53.4 0.2 9.2e-14 51.5 0.2 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG85141.1 - 0.069 12.5 1.0 0.62 9.4 0.5 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 CRG85142.1 - 1.7e-40 139.0 0.0 1.1e-35 123.4 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG85142.1 - 2.1e-38 131.8 0.0 2.8e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG85142.1 - 3e-12 46.8 0.1 5.2e-12 46.1 0.1 1.3 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG85142.1 - 4.6e-05 23.0 0.1 0.00093 18.7 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG85142.1 - 0.0052 16.2 0.0 0.078 12.4 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Blt1_C PF17183.4 CRG85142.1 - 0.31 10.7 1.0 0.85 9.3 1.0 1.7 1 0 0 1 1 1 0 Get5 carboxyl domain WLM PF08325.10 CRG85143.1 - 0.001 19.2 0.4 0.001 19.2 0.4 1.6 2 0 0 2 2 2 1 WLM domain DEAD PF00270.29 CRG85146.1 - 1.5e-49 168.2 0.0 3.7e-49 166.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG85146.1 - 1.4e-27 96.3 0.0 4.8e-27 94.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG85146.1 - 0.018 15.1 0.0 0.045 13.7 0.0 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Alpha-L-AF_C PF06964.12 CRG85147.1 - 4.6e-29 101.7 0.0 6.8e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Glyco_hydro_30C PF17189.4 CRG85147.1 - 0.1 12.8 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 30 beta sandwich domain Nefa_Nip30_N PF10187.9 CRG85150.1 - 1e-33 115.8 12.6 1e-33 115.8 12.6 2.3 3 0 0 3 3 3 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Seryl_tRNA_N PF02403.22 CRG85150.1 - 0.0031 17.7 4.0 0.0031 17.7 4.0 2.5 2 1 1 3 3 3 1 Seryl-tRNA synthetase N-terminal domain Fmp27_WPPW PF10359.9 CRG85150.1 - 0.14 11.0 5.5 0.18 10.6 5.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain CsgA PF17334.2 CRG85150.1 - 0.46 11.3 3.7 1.1 10.1 2.6 2.2 1 1 0 1 1 1 0 Minor curli fiber component A Aldo_ket_red PF00248.21 CRG85151.1 - 8.1e-42 143.4 0.0 3.1e-40 138.2 0.0 2.3 1 1 0 1 1 1 1 Aldo/keto reductase family CK_II_beta PF01214.18 CRG85152.1 - 1.4e-76 256.4 0.1 1.8e-76 256.0 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Abhydrolase_3 PF07859.13 CRG85154.1 - 1.9e-08 34.4 0.1 4e-08 33.4 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG85154.1 - 0.0025 18.5 0.2 0.0039 17.8 0.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG85154.1 - 0.0078 15.5 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3089 PF11288.8 CRG85154.1 - 0.013 15.0 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) Abhydrolase_1 PF00561.20 CRG85154.1 - 0.041 13.5 0.0 0.061 13.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF915 PF06028.11 CRG85154.1 - 0.048 13.0 0.0 0.082 12.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 CRG85154.1 - 0.082 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Mito_carr PF00153.27 CRG85155.1 - 3.6e-34 116.5 1.8 8.4e-15 54.5 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein JAB PF01398.21 CRG85155.1 - 1.8e-06 27.9 0.2 3.4e-05 23.8 0.2 2.4 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PDR_CDR PF06422.12 CRG85155.1 - 0.13 12.2 0.0 0.38 10.7 0.0 1.8 1 0 0 1 1 1 0 CDR ABC transporter Trypan_PARP PF05887.11 CRG85156.1 - 1.9e-06 27.9 21.0 1.9e-06 27.9 21.0 15.8 11 5 5 17 17 17 6 Procyclic acidic repetitive protein (PARP) HMG_box PF00505.19 CRG85157.1 - 1.8e-05 25.1 4.3 1.8e-05 25.1 4.3 3.6 3 2 0 3 3 3 2 HMG (high mobility group) box HMG_box_2 PF09011.10 CRG85157.1 - 5e-05 23.8 1.6 5e-05 23.8 1.6 3.2 3 1 0 3 3 3 1 HMG-box domain eIF3_subunit PF08597.10 CRG85157.1 - 2.1 8.2 25.2 0.41 10.5 19.6 2.0 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit DIOX_N PF14226.6 CRG85157.1 - 5.6 7.8 8.3 3.9 8.3 0.0 3.0 3 0 0 3 3 3 0 non-haem dioxygenase in morphine synthesis N-terminal Inhibitor_I78 PF11720.8 CRG85159.1 - 4.3e-07 29.9 0.0 5.6e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 CRG85159.1 - 0.012 16.3 0.1 0.013 16.1 0.1 1.3 1 1 0 1 1 1 0 Potato inhibitor I family DUF4407 PF14362.6 CRG85160.1 - 0.12 11.7 1.5 0.18 11.2 1.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CCT_2 PF09425.10 CRG85160.1 - 0.16 11.9 2.9 0.41 10.6 2.9 1.7 1 0 0 1 1 1 0 Divergent CCT motif DUF4690 PF15756.5 CRG85160.1 - 0.44 11.2 3.4 0.94 10.1 0.1 2.5 2 1 0 2 2 2 0 Small Novel Rich in Cartilage DUF2897 PF11446.8 CRG85160.1 - 2.8 7.9 7.0 0.49 10.3 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) VPS9 PF02204.18 CRG85161.1 - 8.6e-17 61.3 0.0 2e-16 60.1 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 CRG85161.1 - 5.7e-16 58.4 0.3 4.9e-13 49.0 0.0 4.1 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG85161.1 - 2.3e-10 40.9 0.0 0.008 16.7 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) PX PF00787.24 CRG85161.1 - 7e-07 29.2 0.1 2e-06 27.7 0.1 1.8 1 0 0 1 1 1 1 PX domain Ribosomal_S11 PF00411.19 CRG85161.1 - 1.8e-05 25.1 0.0 5.1e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 Ribosomal protein S11 Ank_4 PF13637.6 CRG85161.1 - 0.00015 22.3 0.1 2.6 8.7 0.0 4.3 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG85161.1 - 0.031 14.7 0.3 16 6.2 0.0 3.7 4 0 0 4 4 4 0 Ankyrin repeat Ank_3 PF13606.6 CRG85161.1 - 0.13 12.9 0.1 70 4.5 0.0 4.6 4 0 0 4 4 4 0 Ankyrin repeat BsuBI_PstI_RE_N PF17728.1 CRG85161.1 - 0.34 10.8 1.7 0.53 10.1 0.4 2.0 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease HTH domain Tim44 PF04280.15 CRG85162.1 - 2.1e-35 122.0 0.0 5.7e-35 120.6 0.0 1.7 2 0 0 2 2 2 1 Tim44-like domain FancD2 PF14631.6 CRG85162.1 - 0.16 9.4 3.3 0.21 8.9 3.3 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease LRRC37AB_C PF14914.6 CRG85162.1 - 0.54 10.2 2.4 1.3 9.0 2.4 1.6 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Ndc1_Nup PF09531.10 CRG85162.1 - 4.5 5.8 10.3 5.7 5.5 10.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Vpu PF00558.19 CRG85162.1 - 7.4 6.4 6.2 20 5.0 6.2 1.7 1 0 0 1 1 1 0 Vpu protein Neur_chan_memb PF02932.16 CRG85162.1 - 8.9 6.3 13.4 4.2 7.4 9.9 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SGTA_dimer PF16546.5 CRG85164.1 - 1.8e-25 88.5 0.4 3e-25 87.8 0.4 1.4 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 CRG85164.1 - 3e-14 52.1 4.8 9.8e-05 22.0 0.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 CRG85164.1 - 6.8e-13 47.7 7.6 0.00037 20.4 0.8 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 CRG85164.1 - 9.2e-10 38.1 10.2 1.3e-05 24.8 1.6 3.3 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 CRG85164.1 - 2.4e-08 33.6 5.3 0.002 18.2 0.2 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG85164.1 - 1.6e-06 28.1 1.0 0.00051 20.2 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG85164.1 - 3e-06 27.4 5.6 0.0019 18.5 0.8 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG85164.1 - 4.4e-06 26.4 0.7 1.3 9.2 0.1 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG85164.1 - 1.4e-05 25.5 5.5 0.11 13.3 0.3 3.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 CRG85164.1 - 3.2e-05 24.5 18.5 0.00088 19.9 2.5 3.1 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG85164.1 - 0.00012 22.5 3.9 0.0019 18.7 0.5 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG85164.1 - 0.0002 21.5 1.6 0.00097 19.2 0.6 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat STI1 PF17830.1 CRG85164.1 - 0.00039 20.3 8.7 0.00067 19.5 3.7 2.3 2 0 0 2 2 2 1 STI1 domain XPC-binding PF09280.11 CRG85164.1 - 0.0013 18.4 1.7 0.0026 17.5 1.7 1.5 1 0 0 1 1 1 1 XPC-binding domain TPR_6 PF13174.6 CRG85164.1 - 0.0023 18.5 4.3 0.28 11.9 0.4 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 CRG85164.1 - 0.005 16.7 8.2 0.1 12.5 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 CRG85164.1 - 0.021 14.9 1.9 1.6 8.9 0.1 2.8 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_4 PF07721.14 CRG85164.1 - 0.026 15.1 0.9 8.8 7.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat RIC1 PF07064.13 CRG85165.1 - 2.4e-86 289.3 0.1 4.1e-86 288.5 0.1 1.4 1 0 0 1 1 1 1 RIC1 Pre-PUA PF17832.1 CRG85166.1 - 5.9e-22 78.2 0.1 8.6e-22 77.6 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 CRG85166.1 - 5.4e-16 58.3 0.3 7.9e-16 57.8 0.3 1.3 1 0 0 1 1 1 1 PUA domain DUF1947 PF09183.10 CRG85166.1 - 0.16 12.3 0.1 0.39 11.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) EHN PF06441.12 CRG85167.1 - 5e-31 107.3 0.0 8.8e-31 106.5 0.0 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG85167.1 - 3.7e-07 30.1 0.0 6.3e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold YchF-GTPase_C PF06071.13 CRG85169.1 - 5.4e-36 122.6 0.1 1.4e-35 121.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 CRG85169.1 - 2.5e-16 59.8 0.0 7.6e-16 58.2 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 CRG85169.1 - 0.00063 19.7 0.0 0.002 18.1 0.0 1.9 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 CRG85169.1 - 0.00075 19.1 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Sugar_tr PF00083.24 CRG85171.1 - 4.7e-105 352.1 21.3 5.5e-105 351.8 21.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG85171.1 - 1.1e-30 106.8 51.2 4.1e-26 91.8 25.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Band_7 PF01145.25 CRG85172.1 - 1.1e-29 103.7 0.5 1.1e-29 103.7 0.5 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 CRG85172.1 - 1.4e-24 85.9 0.7 1.4e-24 85.9 0.7 2.3 2 0 0 2 2 2 1 C-terminal region of band_7 Pox_A11 PF05061.13 CRG85172.1 - 0.12 11.6 0.2 0.19 11.0 0.2 1.2 1 0 0 1 1 1 0 Poxvirus A11 Protein Hira PF07569.11 CRG85173.1 - 3.4e-83 278.7 0.1 6.8e-83 277.8 0.1 1.5 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 CRG85173.1 - 3.6e-26 90.9 27.2 2.7e-05 24.9 0.0 8.9 7 1 1 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85173.1 - 9.3e-13 48.3 0.0 0.4 11.0 0.1 5.8 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 CRG85173.1 - 9.5e-11 41.3 0.1 3.4e-10 39.5 0.1 2.1 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 CRG85173.1 - 1e-05 25.3 1.1 0.45 10.5 0.0 5.5 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CRG85173.1 - 0.0029 16.6 0.1 1.9 7.4 0.0 3.9 3 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 CRG85173.1 - 0.27 9.2 0.0 0.51 8.3 0.0 1.3 1 0 0 1 1 1 0 IKI3 family Mucin PF01456.17 CRG85173.1 - 0.67 9.9 13.9 1.7 8.6 13.9 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein La PF05383.17 CRG85175.1 - 5.4e-19 68.0 0.4 9.6e-19 67.2 0.4 1.4 1 0 0 1 1 1 1 La domain RRN9 PF10680.9 CRG85175.1 - 0.71 10.2 5.9 9.1 6.6 2.1 3.8 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor NPR3 PF03666.13 CRG85176.1 - 1.5e-152 508.7 0.5 1.5e-152 508.7 0.5 2.5 3 0 0 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 DFRP_C PF16543.5 CRG85176.1 - 0.95 10.0 9.8 0.24 11.9 5.6 2.2 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 CHCH PF06747.13 CRG85177.1 - 0.0011 19.0 1.1 0.0022 18.1 1.1 1.6 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.13 CRG85177.1 - 0.017 14.8 0.3 0.021 14.5 0.3 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 CRG85177.1 - 0.024 14.9 1.9 0.088 13.1 1.9 1.8 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Pox_F12L PF03337.13 CRG85177.1 - 0.046 11.9 0.0 0.054 11.6 0.0 1.0 1 0 0 1 1 1 0 Poxvirus F12L protein COX17 PF05051.13 CRG85177.1 - 0.054 13.9 2.1 0.28 11.6 0.3 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Aldo_ket_red PF00248.21 CRG85179.1 - 2.7e-48 164.7 0.0 5.7e-48 163.6 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family PAP2 PF01569.21 CRG85180.1 - 1.4e-27 96.1 2.6 8.3e-27 93.6 2.6 2.2 1 1 0 1 1 1 1 PAP2 superfamily DUF805 PF05656.14 CRG85180.1 - 0.1 13.0 0.7 9.2 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF805) Mod_r PF07200.13 CRG85181.1 - 2.7e-26 92.4 4.3 3.3e-26 92.1 4.3 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein Nbl1_Borealin_N PF10444.9 CRG85181.1 - 0.021 14.5 0.7 0.32 10.7 0.0 2.3 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal PSK_trans_fac PF07704.11 CRG85181.1 - 4.5 8.1 6.8 1.1 10.0 2.4 2.0 2 0 0 2 2 2 0 Rv0623-like transcription factor Ank_5 PF13857.6 CRG85182.1 - 4.4e-12 46.0 0.1 7.2e-10 38.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG85182.1 - 7.8e-09 35.9 0.1 7.6e-07 29.6 0.1 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG85182.1 - 1.8e-08 34.9 0.2 2.8e-08 34.2 0.2 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG85182.1 - 4.4e-07 29.7 0.3 3.2e-05 24.0 0.2 3.0 2 1 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 CRG85182.1 - 1.3e-05 25.4 0.2 0.0026 18.1 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeat VHL_C PF17211.3 CRG85182.1 - 0.0056 16.7 0.0 0.073 13.1 0.0 2.3 2 0 0 2 2 2 1 VHL box domain YejG PF13989.6 CRG85182.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 YejG-like protein RNA_lig_T4_1 PF09511.10 CRG85183.1 - 6.1e-86 287.8 0.1 1.1e-85 287.0 0.1 1.4 1 0 0 1 1 1 1 RNA ligase tRNA_lig_CPD PF08302.11 CRG85183.1 - 4.8e-83 278.5 0.0 7e-83 278.0 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 CRG85183.1 - 2.8e-51 173.9 0.2 9.5e-51 172.2 0.2 1.9 2 0 0 2 2 2 1 tRNA ligase kinase domain COQ7 PF03232.13 CRG85183.1 - 0.14 11.9 0.1 0.36 10.6 0.1 1.6 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 Got1 PF04178.12 CRG85184.1 - 5.5e-36 123.4 15.4 7.4e-36 123.0 15.4 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family HLH PF00010.26 CRG85185.1 - 5.3e-12 45.5 0.0 2.1e-11 43.6 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mito_carr PF00153.27 CRG85186.1 - 3.4e-66 219.2 1.3 2.4e-24 85.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CRG85186.1 - 0.016 14.3 0.6 13 4.8 0.0 3.4 4 0 0 4 4 4 0 Gammaproteobacterial serine protease CytB6-F_Fe-S PF08802.10 CRG85186.1 - 3.2 7.9 5.0 1.1 9.3 0.4 2.4 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit AIP3 PF03915.13 CRG85189.1 - 4.4e-155 516.8 10.8 4.4e-155 516.8 10.8 1.5 2 0 0 2 2 2 1 Actin interacting protein 3 Med11 PF10280.9 CRG85189.1 - 0.021 15.3 0.3 0.13 12.7 0.0 2.5 2 0 0 2 2 2 0 Mediator complex protein Lectin_N PF03954.14 CRG85189.1 - 0.029 14.1 2.7 0.029 14.1 0.1 2.4 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain NPV_P10 PF05531.12 CRG85189.1 - 0.083 13.4 3.1 0.18 12.3 0.1 3.1 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein RasGAP_C PF03836.15 CRG85189.1 - 0.099 12.8 0.1 1.1 9.4 0.0 2.9 3 1 0 3 3 3 0 RasGAP C-terminus Syntaxin_2 PF14523.6 CRG85189.1 - 0.95 9.9 4.5 3 8.3 0.2 3.3 2 1 1 3 3 3 0 Syntaxin-like protein Sec34 PF04136.15 CRG85189.1 - 1.6 8.6 7.0 0.81 9.6 0.8 3.2 4 1 1 5 5 5 0 Sec34-like family DUF1664 PF07889.12 CRG85189.1 - 3.9 7.5 7.1 1.8 8.6 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) LsmAD PF06741.13 CRG85190.1 - 9.2e-28 96.6 4.1 9.2e-28 96.6 4.1 2.3 3 0 0 3 3 3 1 LsmAD domain SM-ATX PF14438.6 CRG85190.1 - 1.8e-21 76.1 0.1 3.8e-21 75.0 0.1 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain Pkinase PF00069.25 CRG85191.1 - 1.7e-10 40.8 0.0 3.4e-10 39.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 CRG85191.1 - 3e-07 30.1 0.2 0.065 13.5 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 CRG85191.1 - 5.1e-07 29.9 0.0 1.6e-06 28.2 0.0 1.8 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Pkinase_Tyr PF07714.17 CRG85191.1 - 7.3e-05 22.2 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_EZ PF13513.6 CRG85191.1 - 0.00012 22.5 0.3 0.26 11.8 0.1 3.4 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 CRG85191.1 - 0.004 17.5 0.2 0.44 11.0 0.0 3.2 1 1 2 3 3 3 2 HEAT repeats Adaptin_N PF01602.20 CRG85191.1 - 0.055 12.0 0.0 1.1 7.8 0.0 2.0 1 1 0 1 1 1 0 Adaptin N terminal region Kinase-like PF14531.6 CRG85191.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like CoA_trans PF01144.23 CRG85191.1 - 0.16 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 Coenzyme A transferase CLASP_N PF12348.8 CRG85191.1 - 0.18 11.4 0.1 15 5.1 0.0 2.7 1 1 0 2 2 2 0 CLASP N terminal Acetyltransf_1 PF00583.25 CRG85195.1 - 4.5e-11 43.0 0.0 7.6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG85195.1 - 2.2e-07 30.9 0.2 3.2e-07 30.3 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG85195.1 - 3.8e-07 30.0 0.1 6.9e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 CRG85195.1 - 2.4e-05 24.6 0.0 5.5e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG85195.1 - 0.0086 16.2 0.3 0.013 15.5 0.3 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ketoacyl-synt PF00109.26 CRG85198.1 - 1.2e-56 192.2 0.0 2e-56 191.4 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG85198.1 - 4.2e-53 179.9 1.3 8.8e-53 178.9 0.3 2.1 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 CRG85198.1 - 4.3e-47 160.8 0.0 7.4e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG85198.1 - 1.4e-38 133.2 0.0 2.7e-38 132.3 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG85198.1 - 3.2e-32 111.0 1.6 1.9e-31 108.5 1.7 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG85198.1 - 2.3e-17 63.5 0.0 5.7e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 CRG85198.1 - 2.7e-17 64.1 0.0 1.1e-16 62.0 0.0 2.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG85198.1 - 6.7e-13 48.8 0.0 2.8e-12 46.7 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG85198.1 - 9.3e-09 35.0 0.6 8.4e-08 31.9 0.2 2.6 3 0 0 3 3 3 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85198.1 - 2.7e-07 30.4 0.1 7.7e-07 28.9 0.1 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CRG85198.1 - 2.1e-06 28.0 0.0 6.2e-06 26.5 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 CRG85198.1 - 1.8e-05 24.5 0.8 4.5e-05 23.3 0.8 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain SAT PF16073.5 CRG85198.1 - 0.00051 19.9 0.2 0.0036 17.0 0.2 2.1 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis AXE1 PF05448.12 CRG85199.1 - 6.7e-13 48.0 0.0 4.9e-09 35.3 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 CRG85199.1 - 5.7e-11 43.4 0.0 7.7e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG85199.1 - 7.9e-07 28.6 0.0 5.2e-05 22.6 0.0 2.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG85199.1 - 9.8e-05 22.1 0.0 0.064 12.9 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG85199.1 - 0.00087 18.8 0.0 0.26 10.7 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 CRG85199.1 - 0.0054 16.3 0.0 0.0085 15.7 0.0 1.3 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 CRG85199.1 - 0.047 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 CRG85199.1 - 0.051 13.1 0.0 0.075 12.6 0.0 1.1 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase BAAT_C PF08840.11 CRG85199.1 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 CRG85199.1 - 0.19 11.3 0.1 0.48 10.0 0.1 1.8 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) p450 PF00067.22 CRG85200.1 - 2.2e-53 181.7 0.0 5.3e-53 180.4 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CRG85200.1 - 1.3e-14 54.1 0.0 2.1e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85200.1 - 1.5e-08 34.5 0.0 2.3e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85200.1 - 2.9e-05 24.0 0.0 5.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG85200.1 - 0.00031 20.7 0.1 0.0005 20.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding HTH_51 PF18558.1 CRG85201.1 - 1.6e-29 101.6 0.0 2.8e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Methyltransf_12 PF08242.12 CRG85201.1 - 1.1e-14 54.9 0.0 2.7e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG85201.1 - 1.7e-10 41.0 0.0 6e-10 39.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85201.1 - 3.1e-07 31.0 0.0 6.9e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85201.1 - 5.9e-06 26.9 0.0 1.7e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85201.1 - 2.2e-05 24.3 0.0 3.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_33 PF10017.9 CRG85201.1 - 0.0012 18.1 0.0 0.0025 17.0 0.0 1.5 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent DREV PF05219.12 CRG85201.1 - 0.01 14.9 0.0 0.17 10.9 0.0 2.2 2 0 0 2 2 2 0 DREV methyltransferase Methyltransf_24 PF13578.6 CRG85201.1 - 0.086 13.9 0.1 0.79 10.8 0.1 2.3 1 1 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 CRG85201.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ank_2 PF12796.7 CRG85202.1 - 1.8e-25 89.3 0.1 1.1e-12 48.3 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG85202.1 - 8.3e-22 77.3 0.3 3.6e-10 40.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG85202.1 - 8.4e-18 62.6 1.7 0.00092 19.5 0.1 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 CRG85202.1 - 1.2e-17 63.5 2.4 0.00017 21.9 0.1 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 CRG85202.1 - 4.5e-14 52.3 0.8 2.7e-07 30.7 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) MAGE_N PF12440.8 CRG85202.1 - 0.056 14.1 1.4 0.091 13.4 1.4 1.3 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal bZIP_1 PF00170.21 CRG85202.1 - 0.18 11.9 7.1 0.34 11.0 7.1 1.4 1 0 0 1 1 1 0 bZIP transcription factor FAD_binding_4 PF01565.23 CRG85203.1 - 6.6e-20 71.3 0.8 1.4e-19 70.3 0.8 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG85203.1 - 3.7e-07 30.1 1.9 8.8e-07 28.9 1.9 1.6 1 0 0 1 1 1 1 Berberine and berberine like SUR7 PF06687.12 CRG85205.1 - 5.5e-43 147.1 15.5 8.5e-43 146.4 15.5 1.3 1 0 0 1 1 1 1 SUR7/PalI family WD40 PF00400.32 CRG85205.1 - 2.3e-33 113.6 15.1 2.9e-09 37.4 0.1 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85205.1 - 1.4e-06 28.5 0.3 1 9.7 0.0 4.7 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 CRG85205.1 - 0.0039 16.2 1.8 0.0052 15.8 0.1 2.0 2 0 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 CRG85205.1 - 0.0059 15.3 9.2 0.45 9.1 0.1 3.5 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CRG85205.1 - 0.06 12.3 0.0 10 4.9 0.0 3.1 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CRG85205.1 - 0.063 13.2 0.1 0.33 10.8 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DMT_YdcZ PF04657.13 CRG85205.1 - 1.4 9.2 11.7 0.28 11.5 7.8 1.9 2 0 0 2 2 2 0 Putative inner membrane exporter, YdcZ Fig1 PF12351.8 CRG85205.1 - 2.7 7.9 13.7 0.6 10.0 9.3 2.1 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 DUF2207 PF09972.9 CRG85205.1 - 3.3 6.4 4.6 1.9 7.2 1.4 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Tetraspanin PF00335.20 CRG85205.1 - 6 6.5 9.2 15 5.2 7.0 2.3 2 0 0 2 2 2 0 Tetraspanin family Tctex-1 PF03645.13 CRG85206.1 - 2.4e-34 117.6 0.0 2.8e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Tctex-1 family DUF202 PF02656.15 CRG85207.1 - 8.6e-14 51.7 7.8 1.4e-13 51.1 5.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF5337 PF17272.2 CRG85207.1 - 6.5 6.7 9.5 1.6 8.6 5.3 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5337) SPATA3 PF15662.5 CRG85208.1 - 0.021 15.5 7.8 0.021 15.5 7.8 2.6 2 0 0 2 2 2 0 Spermatogenesis-associated protein 3 family Macoilin PF09726.9 CRG85210.1 - 0.043 12.4 1.3 0.043 12.4 1.3 1.0 1 0 0 1 1 1 0 Macoilin family CFEM PF05730.11 CRG85210.1 - 0.88 9.7 13.7 2.4 8.3 13.7 2.0 1 1 0 1 1 1 0 CFEM domain FAM199X PF15814.5 CRG85210.1 - 1.3 8.0 10.5 1.5 7.8 10.5 1.2 1 0 0 1 1 1 0 Protein family FAM199X HECT PF00632.25 CRG85212.1 - 7.6e-98 327.8 0.0 1.1e-97 327.3 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 CRG85212.1 - 9.2e-34 115.2 21.7 3.8e-12 46.1 2.7 3.9 4 0 0 4 4 4 3 WW domain C2 PF00168.30 CRG85212.1 - 7.7e-19 67.9 0.0 1.9e-18 66.6 0.0 1.7 1 0 0 1 1 1 1 C2 domain RRM_1 PF00076.22 CRG85212.1 - 5.9e-15 54.8 0.0 1.6e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GGDEF PF00990.21 CRG85212.1 - 0.099 12.4 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Diguanylate cyclase, GGDEF domain Nup35_RRM_2 PF14605.6 CRG85212.1 - 0.12 12.4 0.0 0.44 10.6 0.0 2.0 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF724 PF05266.14 CRG85212.1 - 1.6 8.5 6.3 2.8 7.7 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) GPS2_interact PF15784.5 CRG85212.1 - 1.7 9.2 4.9 4.5 7.8 4.9 1.7 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Spc7 PF08317.11 CRG85212.1 - 1.7 7.5 6.0 2.8 6.8 6.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein bZIP_1 PF00170.21 CRG85212.1 - 2.5 8.3 5.6 6.3 7.0 5.6 1.7 1 0 0 1 1 1 0 bZIP transcription factor Troponin PF00992.20 CRG85212.1 - 5.7 7.2 11.9 3.9 7.8 9.3 1.9 2 0 0 2 2 2 0 Troponin DivIC PF04977.15 CRG85212.1 - 8.9 6.2 6.4 23 4.9 6.4 1.7 1 0 0 1 1 1 0 Septum formation initiator Metallophos_2 PF12850.7 CRG85213.1 - 2.8e-12 47.1 0.0 3.4e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Aminotran_5 PF00266.19 CRG85214.1 - 8.8e-31 107.2 0.0 1.1e-30 106.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CRG85214.1 - 0.0021 17.3 0.0 0.004 16.4 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II KR PF08659.10 CRG85214.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 KR domain B12-binding PF02310.19 CRG85214.1 - 0.077 13.0 0.5 0.2 11.7 0.0 2.0 2 0 0 2 2 2 0 B12 binding domain OspD PF03207.13 CRG85214.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) NIF PF03031.18 CRG85215.1 - 5.4e-56 188.7 0.0 8.8e-56 188.0 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase IF-2B PF01008.17 CRG85216.1 - 4.8e-61 206.4 1.6 1.3e-58 198.4 1.6 2.7 1 1 0 1 1 1 1 Initiation factor 2 subunit family Ribosom_S12_S23 PF00164.25 CRG85217.1 - 1.3e-50 169.8 0.8 1.6e-50 169.5 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF5315 PF17242.2 CRG85219.1 - 3.5e-23 81.2 5.9 3.5e-23 81.2 5.9 1.9 2 0 0 2 2 2 1 Disordered region of unknown function (DUF5315) Cluap1 PF10234.9 CRG85219.1 - 0.0041 16.5 7.4 0.0063 15.9 7.4 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 AIM5 PF17050.5 CRG85220.1 - 1.1e-13 51.7 0.9 1.8e-13 51.1 0.9 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 Tom5 PF10642.9 CRG85220.1 - 2.8 8.0 4.2 19 5.4 0.3 2.8 2 1 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Ribosomal_L17 PF01196.19 CRG85221.1 - 1.7e-34 118.6 0.0 2.7e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 SUZ PF12752.7 CRG85222.1 - 2.1e-17 63.6 9.4 2.1e-17 63.6 9.4 3.9 3 1 0 3 3 3 1 SUZ domain R3H PF01424.22 CRG85222.1 - 2.4e-08 33.8 0.0 5.8e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 R3H domain cwf18 PF08315.12 CRG85223.1 - 7.2e-44 149.7 6.4 1.1e-43 149.2 6.4 1.2 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor PPR_2 PF13041.6 CRG85224.1 - 6.9e-13 48.6 10.9 0.00024 21.2 0.1 5.3 5 1 1 6 6 6 3 PPR repeat family PPR_3 PF13812.6 CRG85224.1 - 6.6e-11 42.1 0.6 0.0016 18.5 0.0 4.1 2 2 2 4 4 4 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 CRG85224.1 - 0.00025 20.7 0.8 3.6 7.4 0.0 4.6 6 0 0 6 6 6 2 PPR repeat PPR PF01535.20 CRG85224.1 - 0.0018 18.4 5.1 4.6 7.7 0.0 5.6 6 0 0 6 6 6 2 PPR repeat NYD-SP28 PF14772.6 CRG85224.1 - 0.0067 16.5 0.9 0.0067 16.5 0.9 1.9 2 0 0 2 2 2 1 Sperm tail PPR_long PF17177.4 CRG85224.1 - 0.015 14.7 0.1 0.26 10.6 0.0 2.6 2 1 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP TFIID-18kDa PF02269.16 CRG85226.1 - 6.8e-23 80.5 0.0 1e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 CRG85226.1 - 7.7e-05 22.6 0.1 0.00014 21.8 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 CRG85226.1 - 0.0021 18.4 0.1 0.0021 18.4 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CRG85226.1 - 0.0057 16.8 0.3 0.0096 16.0 0.3 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 CRG85226.1 - 0.0081 16.2 0.1 0.013 15.6 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 CRG85226.1 - 0.017 15.5 0.3 0.032 14.6 0.3 1.4 1 0 0 1 1 1 0 CENP-S protein CBFD_NFYB_HMF PF00808.23 CRG85226.1 - 0.019 15.2 0.8 0.035 14.4 0.2 1.8 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 CRG85226.1 - 0.051 13.7 1.8 0.068 13.4 0.4 1.8 2 0 0 2 2 2 0 TATA box binding protein associated factor (TAF) HTH_11 PF08279.12 CRG85226.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.5 1 1 0 1 1 1 0 HTH domain Sulfotransfer_4 PF17784.1 CRG85227.1 - 3.7e-64 216.5 0.0 4.5e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CRG85227.1 - 0.00038 20.9 0.2 0.0052 17.2 0.1 2.6 2 2 0 2 2 2 1 Sulfotransferase family JAB PF01398.21 CRG85228.1 - 2.7e-20 72.5 0.0 5.2e-20 71.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CRG85228.1 - 4e-19 69.1 0.2 7.1e-19 68.3 0.2 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function UPF0172 PF03665.13 CRG85228.1 - 0.00021 21.4 0.0 0.00042 20.4 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) UTP25 PF06862.12 CRG85229.1 - 1.4e-187 624.2 0.3 2.1e-187 623.7 0.3 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 EamA PF00892.20 CRG85229.1 - 1.4e-17 64.1 27.2 5.3e-14 52.6 5.8 2.5 2 1 0 2 2 2 2 EamA-like transporter family CTP_transf_like PF01467.26 CRG85232.1 - 1e-29 103.6 0.0 2.2e-29 102.5 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like MCM_bind PF09739.9 CRG85232.1 - 0.071 11.5 2.4 0.12 10.8 2.4 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor HIGH_NTase1 PF05636.11 CRG85232.1 - 0.12 11.5 2.8 0.65 9.1 0.0 2.1 2 0 0 2 2 2 0 HIGH Nucleotidyl Transferase PP2C PF00481.21 CRG85233.1 - 1.4e-81 274.0 0.1 2e-81 273.4 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C He_PIG PF05345.12 CRG85234.1 - 1.4e-17 63.5 18.3 7.9e-05 22.8 0.6 4.8 4 0 0 4 4 4 4 Putative Ig domain DUF4448 PF14610.6 CRG85234.1 - 0.00037 20.3 0.0 0.00089 19.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SKG6 PF08693.10 CRG85234.1 - 0.0004 19.7 2.4 0.00083 18.7 2.4 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 CRG85234.1 - 0.0066 16.4 0.1 0.017 15.0 0.1 1.8 1 0 0 1 1 1 1 TMEM154 protein family Shisa PF13908.6 CRG85234.1 - 0.011 16.0 0.8 0.031 14.5 0.1 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Adeno_E3_CR2 PF02439.15 CRG85234.1 - 0.034 13.9 5.4 0.063 13.0 5.4 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 CRG85234.1 - 0.043 14.7 0.0 0.14 13.0 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Phage_tail_APC PF16778.5 CRG85234.1 - 0.11 12.4 0.2 0.25 11.3 0.2 1.6 1 0 0 1 1 1 0 Phage tail assembly chaperone protein MOZART1 PF12554.8 CRG85235.1 - 1.1e-25 89.1 0.9 1.3e-25 88.9 0.9 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated PRA-PH PF01503.17 CRG85235.1 - 0.016 15.6 0.0 4 7.9 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase CUE PF02845.16 CRG85236.1 - 7.7e-12 44.7 0.0 1.2e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 CUE domain HA2 PF04408.23 CRG85237.1 - 1.7e-16 60.4 0.0 4e-16 59.2 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CRG85237.1 - 4.2e-16 59.1 0.0 1e-15 57.9 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CRG85237.1 - 2.9e-12 46.9 0.0 6.5e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 CRG85237.1 - 5.6e-05 23.4 0.0 0.00015 22.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG85237.1 - 8.1e-05 22.4 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG85237.1 - 0.00013 22.3 0.0 0.00034 21.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 CRG85237.1 - 0.0014 18.4 0.7 0.0056 16.5 0.7 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase cobW PF02492.19 CRG85237.1 - 0.0093 15.6 0.3 0.34 10.5 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 CRG85237.1 - 0.056 13.6 0.2 0.22 11.7 0.2 2.0 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CRG85237.1 - 0.061 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 CRG85237.1 - 0.089 11.8 0.2 0.22 10.6 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CRG85237.1 - 0.15 11.4 0.0 2.2 7.6 0.0 2.5 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_23 PF13476.6 CRG85237.1 - 1.3 9.5 3.7 0.6 10.6 0.2 2.1 3 0 0 3 3 3 0 AAA domain PITH PF06201.13 CRG85239.1 - 2.5e-42 144.7 0.0 3e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 PITH domain NicO PF03824.16 CRG85239.1 - 0.096 12.0 1.1 0.15 11.4 1.1 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Snf7 PF03357.21 CRG85240.1 - 4.1e-32 111.2 10.4 4.1e-32 111.2 10.4 1.3 1 1 0 1 1 1 1 Snf7 IL22 PF14565.6 CRG85240.1 - 0.053 13.8 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor Adenine_deam_C PF13382.6 CRG85240.1 - 0.063 12.6 0.4 0.11 11.8 0.4 1.4 1 0 0 1 1 1 0 Adenine deaminase C-terminal domain AAA PF00004.29 CRG85241.1 - 2.9e-89 296.3 0.0 6.8e-44 149.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG85241.1 - 1e-20 73.2 3.7 3.2e-10 39.6 0.2 2.8 2 0 0 2 2 2 2 AAA+ lid domain AAA_22 PF13401.6 CRG85241.1 - 7.7e-14 52.1 0.2 0.0071 16.6 0.0 5.3 2 2 3 5 5 5 2 AAA domain RuvB_N PF05496.12 CRG85241.1 - 1.3e-13 51.0 0.0 4.1e-06 26.6 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CRG85241.1 - 2e-13 51.1 2.6 0.00013 22.4 0.1 4.6 3 2 1 4 4 4 2 AAA ATPase domain AAA_2 PF07724.14 CRG85241.1 - 3.7e-11 43.4 0.0 0.00012 22.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CRG85241.1 - 4.2e-11 43.0 0.2 0.00058 19.9 0.1 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CRG85241.1 - 3.4e-10 40.3 0.0 0.00011 22.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 CRG85241.1 - 1.3e-08 34.4 0.0 0.00031 20.0 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 CRG85241.1 - 2.1e-08 34.5 0.0 0.0017 18.8 0.0 2.8 2 1 0 2 2 2 2 RNA helicase AAA_14 PF13173.6 CRG85241.1 - 1.4e-07 31.6 0.0 0.0066 16.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CRG85241.1 - 2.9e-07 30.4 0.1 0.026 14.3 0.0 2.6 2 1 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 CRG85241.1 - 3.5e-07 29.8 0.4 0.018 14.4 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CRG85241.1 - 3.6e-07 30.6 0.0 0.0073 16.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 CRG85241.1 - 7.9e-07 29.1 0.3 0.021 14.7 0.0 3.9 4 1 0 5 5 4 2 NACHT domain AAA_18 PF13238.6 CRG85241.1 - 8e-07 29.7 0.0 0.042 14.4 0.0 3.1 2 1 1 3 3 3 2 AAA domain AAA_3 PF07726.11 CRG85241.1 - 8.5e-07 28.9 0.0 0.0041 17.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 CRG85241.1 - 3e-06 26.7 0.0 0.065 12.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin TsaE PF02367.17 CRG85241.1 - 3.1e-06 27.2 0.0 0.037 14.0 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 CRG85241.1 - 1.1e-05 25.1 0.8 0.47 10.0 0.0 3.5 2 1 1 3 3 3 2 AAA domain AAA_17 PF13207.6 CRG85241.1 - 2.5e-05 24.7 0.1 0.088 13.2 0.1 3.4 2 1 0 2 2 2 1 AAA domain ATPase PF06745.13 CRG85241.1 - 2.7e-05 23.6 0.0 0.48 9.7 0.0 3.2 2 1 0 3 3 3 2 KaiC Cytidylate_kin2 PF13189.6 CRG85241.1 - 3.8e-05 23.9 0.0 0.0063 16.7 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_7 PF12775.7 CRG85241.1 - 4.2e-05 23.1 0.0 0.15 11.6 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region ABC_tran PF00005.27 CRG85241.1 - 7.1e-05 23.3 0.0 0.48 10.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PhoH PF02562.16 CRG85241.1 - 0.00011 21.8 0.0 0.13 11.6 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AFG1_ATPase PF03969.16 CRG85241.1 - 0.00011 21.2 0.0 0.025 13.5 0.0 2.4 2 0 0 2 2 2 1 AFG1-like ATPase Rad17 PF03215.15 CRG85241.1 - 0.00011 22.2 0.0 0.52 10.2 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain TniB PF05621.11 CRG85241.1 - 0.00014 21.3 0.0 0.22 10.9 0.0 3.8 4 0 0 4 4 4 1 Bacterial TniB protein Sigma54_activat PF00158.26 CRG85241.1 - 0.00018 21.2 0.0 0.3 10.8 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain ATPase_2 PF01637.18 CRG85241.1 - 0.00021 21.3 0.1 1.9 8.3 0.0 4.0 3 2 1 4 4 4 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 CRG85241.1 - 0.0003 20.0 0.0 1 8.5 0.0 3.2 3 0 0 3 3 3 2 NB-ARC domain AAA_24 PF13479.6 CRG85241.1 - 0.00044 20.0 0.0 0.93 9.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CRG85241.1 - 0.0013 18.5 0.0 1.7 8.4 0.0 2.7 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 CRG85241.1 - 0.0014 17.8 0.0 0.045 12.9 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 CRG85241.1 - 0.0014 18.5 0.9 1.9 8.2 0.0 2.7 3 0 0 3 3 2 2 AAA domain Parvo_NS1 PF01057.17 CRG85241.1 - 0.0015 17.7 0.0 1.6 7.7 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Sigma54_activ_2 PF14532.6 CRG85241.1 - 0.0025 17.9 0.0 2.7 8.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain SKI PF01202.22 CRG85241.1 - 0.0035 17.5 0.0 4 7.6 0.0 2.8 2 0 0 2 2 2 0 Shikimate kinase L27_1 PF09058.10 CRG85241.1 - 0.032 14.2 0.2 0.22 11.5 0.1 2.4 2 0 0 2 2 2 0 L27_1 AAA_19 PF13245.6 CRG85241.1 - 0.033 14.5 2.0 11 6.3 0.2 3.2 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CRG85241.1 - 0.05 13.5 0.0 6.9 6.6 0.0 2.8 2 1 1 3 3 2 0 NTPase Vps4_C PF09336.10 CRG85241.1 - 0.054 13.5 0.2 1.9 8.6 0.1 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain SRPRB PF09439.10 CRG85241.1 - 0.055 12.9 0.0 13 5.2 0.0 2.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit CPT PF07931.12 CRG85241.1 - 0.069 13.0 0.0 1.8 8.4 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF2075 PF09848.9 CRG85241.1 - 0.09 12.0 0.0 8.1 5.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 CRG85241.1 - 0.15 11.7 0.2 26 4.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CRG85241.1 - 0.16 11.7 0.0 10 5.9 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IPT PF01745.16 CRG85241.1 - 0.17 11.2 0.0 15 4.9 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase COG5 PF10392.9 CRG85242.1 - 1.6e-38 131.9 4.7 5.6e-38 130.1 0.5 3.2 3 0 0 3 3 3 1 Golgi transport complex subunit 5 COG2 PF06148.11 CRG85242.1 - 0.00044 20.3 0.2 0.0015 18.6 0.2 1.9 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 RTBV_P12 PF06361.11 CRG85242.1 - 0.12 12.8 0.1 0.59 10.6 0.1 2.2 2 1 0 2 2 2 0 Rice tungro bacilliform virus P12 protein Aldolase_II PF00596.21 CRG85243.1 - 5e-46 157.0 0.1 7.3e-46 156.4 0.1 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Amidase PF01425.21 CRG85245.1 - 1.1e-120 403.6 0.0 1.3e-120 403.4 0.0 1.1 1 0 0 1 1 1 1 Amidase SYS1 PF09801.9 CRG85246.1 - 2.1e-55 186.9 12.5 2.4e-55 186.7 12.5 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Filaggrin PF03516.13 CRG85246.1 - 0.32 11.7 6.8 0.52 11.1 6.8 1.2 1 0 0 1 1 1 0 Filaggrin COX6B PF02297.17 CRG85247.1 - 1.8e-24 85.8 3.4 2.2e-24 85.5 3.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb UBA_2 PF08587.11 CRG85247.1 - 0.019 15.1 1.9 3.1 8.0 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) Abi_2 PF07751.11 CRG85247.1 - 0.045 14.0 0.1 0.055 13.7 0.1 1.0 1 0 0 1 1 1 0 Abi-like protein Pet191_N PF10203.9 CRG85247.1 - 0.057 13.7 0.6 0.14 12.5 0.6 1.6 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 Prolamin_like PF05617.11 CRG85247.1 - 0.089 13.0 0.2 0.12 12.6 0.2 1.2 1 0 0 1 1 1 0 Prolamin-like RRM_1 PF00076.22 CRG85248.1 - 6.9e-09 35.4 0.0 1.2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG85248.1 - 0.00025 20.6 0.0 0.00055 19.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BOP1NT PF08145.12 CRG85250.1 - 4.7e-107 357.8 7.7 7.2e-107 357.2 7.7 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 CRG85250.1 - 1.7e-22 79.3 10.8 8.1e-10 39.1 0.2 5.5 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85250.1 - 3.2e-06 27.3 0.0 0.0022 18.3 0.0 3.3 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain zf-C2H2 PF00096.26 CRG85251.1 - 2.8e-05 24.3 11.9 0.0089 16.4 1.8 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG85251.1 - 0.00026 21.3 3.8 0.00026 21.3 3.8 2.0 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG85251.1 - 0.002 18.8 11.5 0.07 14.0 2.9 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger TylF PF05711.11 CRG85251.1 - 0.22 10.7 0.0 0.33 10.2 0.0 1.1 1 0 0 1 1 1 0 Macrocin-O-methyltransferase (TylF) zf-H2C2_5 PF13909.6 CRG85251.1 - 6.9 6.5 7.7 5.3 6.9 1.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Apolipoprotein PF01442.18 CRG85252.1 - 0.0027 17.6 5.2 0.0043 17.0 5.2 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Grg1 PF11034.8 CRG85252.1 - 0.0074 16.5 7.4 0.0074 16.5 7.4 1.5 2 0 0 2 2 2 1 Glucose-repressible protein Grg1 Phasin PF05597.11 CRG85252.1 - 0.015 15.3 3.8 0.016 15.2 2.2 1.8 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) TraB PF01963.17 CRG85252.1 - 0.015 15.2 1.0 0.02 14.8 1.0 1.1 1 0 0 1 1 1 0 TraB family Syntaxin_2 PF14523.6 CRG85252.1 - 0.072 13.5 1.7 0.097 13.1 1.7 1.3 1 0 0 1 1 1 0 Syntaxin-like protein RapA_C PF12137.8 CRG85252.1 - 0.25 10.3 4.7 0.29 10.1 4.7 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal DUF883 PF05957.13 CRG85252.1 - 0.49 11.0 12.8 0.17 12.5 7.1 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Muted PF14942.6 CRG85252.1 - 0.57 10.5 4.6 0.78 10.1 4.6 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Arm-DNA-bind_3 PF13356.6 CRG85252.1 - 1 9.8 11.1 0.72 10.3 0.6 3.1 1 1 2 3 3 3 0 Arm DNA-binding domain CDPS PF16715.5 CRG85252.1 - 7.2 6.2 7.2 37 3.9 7.2 1.9 1 1 0 1 1 1 0 Cyclodipeptide synthase CDT1_C PF16679.5 CRG85253.1 - 4.4e-18 65.5 0.0 4.4e-18 65.5 0.0 2.6 2 1 1 3 3 3 1 DNA replication factor Cdt1 C-terminal domain Spc24 PF08286.11 CRG85253.1 - 0.013 15.7 4.9 0.022 15.0 0.0 2.6 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 RasGAP PF00616.19 CRG85253.1 - 0.086 12.5 3.0 0.56 9.9 1.9 2.2 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase Presenilin PF01080.17 CRG85253.1 - 0.44 9.3 3.3 0.66 8.7 3.3 1.2 1 0 0 1 1 1 0 Presenilin BSP_II PF05432.11 CRG85253.1 - 0.87 9.2 10.8 1.4 8.5 10.8 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Spc7_C2 PF15577.6 CRG85253.1 - 3.2 7.9 7.4 4 7.6 0.3 2.9 3 0 0 3 3 3 0 Spc7_C2 SURF6 PF04935.12 CRG85253.1 - 8.3 6.1 17.8 0.25 11.1 9.6 2.2 2 0 0 2 2 2 0 Surfeit locus protein 6 MutS_V PF00488.21 CRG85254.1 - 2.2e-81 272.4 0.1 3.6e-81 271.7 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CRG85254.1 - 4.4e-38 131.4 1.2 1.4e-37 129.8 1.2 1.9 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 CRG85254.1 - 5.5e-18 65.6 1.8 2e-17 63.8 0.1 2.5 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 CRG85254.1 - 2.5e-17 63.0 1.3 8.4e-17 61.3 1.3 2.0 1 0 0 1 1 1 1 MutS family domain IV MutS_I PF01624.20 CRG85254.1 - 1.2e-14 54.5 0.0 9.7e-14 51.6 0.0 2.3 2 0 0 2 2 2 1 MutS domain I SUR7 PF06687.12 CRG85254.1 - 0.097 12.3 0.0 0.75 9.4 0.0 2.2 2 0 0 2 2 2 0 SUR7/PalI family Sigma70_r2 PF04542.14 CRG85254.1 - 0.17 11.7 0.8 0.67 9.8 0.1 2.4 3 0 0 3 3 3 0 Sigma-70 region 2 Gpi1 PF05024.15 CRG85255.1 - 6.9e-78 261.0 6.4 1.3e-77 260.1 6.4 1.5 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) 7tm_1 PF00001.21 CRG85255.1 - 0.034 13.5 0.8 0.083 12.2 0.5 1.7 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) TauD PF02668.16 CRG85257.1 - 5.5e-48 164.1 0.1 6.9e-48 163.8 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fn3-like PF14310.6 CRG85257.1 - 0.073 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Fibronectin type III-like domain APH PF01636.23 CRG85259.1 - 2.7e-15 57.0 0.0 4.6e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 CRG85259.1 - 0.069 12.0 0.0 0.18 10.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Myb_DNA-binding PF00249.31 CRG85260.1 - 0.0023 18.1 0.0 0.0044 17.2 0.0 1.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 CRG85260.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.4 1 1 0 1 1 1 0 Myb/SANT-like DNA-binding domain UPF0203 PF05254.12 CRG85261.1 - 3.6e-26 91.2 2.6 4.2e-26 91.0 2.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) COX17 PF05051.13 CRG85261.1 - 1.4e-05 25.3 1.2 2.7e-05 24.4 1.2 1.4 1 1 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 CRG85261.1 - 0.00038 20.4 4.2 0.01 15.9 1.3 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 CRG85261.1 - 0.0046 17.1 4.0 0.46 10.7 0.2 2.1 1 1 1 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein NDUF_B7 PF05676.13 CRG85261.1 - 0.01 15.5 5.2 0.1 12.3 0.6 2.2 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF5339 PF17274.2 CRG85261.1 - 0.24 12.3 4.2 0.27 12.1 0.4 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5339) COX6B PF02297.17 CRG85261.1 - 0.49 10.7 6.1 0.5 10.6 0.4 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb DNA_pol_A_exo1 PF01612.20 CRG85262.1 - 2.4e-44 151.2 0.2 3.6e-44 150.6 0.2 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 CRG85262.1 - 2.6e-31 108.2 0.6 2.6e-31 108.2 0.6 2.8 3 0 0 3 3 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 CRG85262.1 - 5.1e-12 45.6 0.4 1.2e-11 44.4 0.0 1.9 2 0 0 2 2 2 1 HRDC domain SR-25 PF10500.9 CRG85262.1 - 7.4e-05 22.5 28.8 0.00013 21.7 28.8 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CRG85262.1 - 0.27 10.9 17.8 0.53 10.0 17.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SRP-alpha_N PF04086.13 CRG85262.1 - 0.29 11.0 16.3 0.53 10.2 16.3 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF515 PF04415.12 CRG85262.1 - 1.3 7.4 15.7 2 6.7 15.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF4614 PF15391.6 CRG85262.1 - 1.7 8.6 17.3 3.3 7.7 17.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) DUF3807 PF12720.7 CRG85262.1 - 3.3 7.9 13.1 7.1 6.9 13.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CDC45 PF02724.14 CRG85262.1 - 4.2 5.5 13.4 7.4 4.7 13.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 CRG85262.1 - 6.3 5.0 9.9 12 4.1 9.9 1.4 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 CRG85262.1 - 7.2 5.0 15.3 12 4.3 15.3 1.3 1 0 0 1 1 1 0 Macoilin family RasGAP PF00616.19 CRG85263.1 - 8.5e-58 195.5 0.0 8.5e-58 195.5 0.0 2.3 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 CRG85263.1 - 2.2e-31 108.8 4.4 2.2e-31 108.8 4.4 2.8 3 0 0 3 3 3 1 RasGAP C-terminus DDE_Tnp_1 PF01609.21 CRG85263.1 - 0.28 10.8 1.6 2 8.0 0.2 2.2 2 0 0 2 2 2 0 Transposase DDE domain SOGA PF11365.8 CRG85263.1 - 2.5 9.3 8.0 2.8 9.2 1.9 3.1 2 0 0 2 2 2 0 Protein SOGA CRAL_TRIO PF00650.20 CRG85264.1 - 4.1e-37 127.4 0.0 6.9e-37 126.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG85264.1 - 8.1e-09 35.5 0.3 1.9e-08 34.3 0.3 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CRG85264.1 - 9.5e-05 22.6 0.0 0.00016 21.9 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Mis14 PF08641.12 CRG85266.1 - 1.1e-25 90.5 1.8 3.3e-25 88.9 0.2 2.3 3 0 0 3 3 3 1 Kinetochore protein Mis14 like Seryl_tRNA_N PF02403.22 CRG85266.1 - 0.032 14.5 0.8 3.1 8.1 0.0 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain CLZ PF16526.5 CRG85266.1 - 0.059 13.7 0.0 0.35 11.3 0.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Pex24p PF06398.11 CRG85267.1 - 4.5e-05 22.6 6.7 4.5e-05 22.6 6.7 1.5 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin DUF4476 PF14771.6 CRG85267.1 - 0.042 14.2 0.0 0.098 13.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) RNase_H2_suC PF08615.11 CRG85267.1 - 0.044 14.0 0.0 0.083 13.1 0.0 1.6 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DIOX_N PF14226.6 CRG85268.1 - 0.11 13.3 0.8 2.1 9.2 0.1 2.5 2 0 0 2 2 2 0 non-haem dioxygenase in morphine synthesis N-terminal LCAT PF02450.15 CRG85269.1 - 3.2e-111 372.3 0.2 3.8e-111 372.0 0.2 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF900 PF05990.12 CRG85269.1 - 0.026 14.0 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_2 PF01674.18 CRG85269.1 - 0.047 13.2 0.1 0.12 11.9 0.1 1.6 1 0 0 1 1 1 0 Lipase (class 2) DUF1749 PF08538.10 CRG85269.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) PAP2_3 PF14378.6 CRG85271.1 - 7.3e-24 84.5 14.1 7.3e-24 84.5 14.1 1.8 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 CRG85271.1 - 5.6e-10 39.1 4.5 5.6e-10 39.1 4.5 2.1 2 0 0 2 2 2 1 PAP2 superfamily VIT1 PF01988.19 CRG85272.1 - 2.2e-60 204.2 2.4 2.6e-60 204.0 2.4 1.1 1 0 0 1 1 1 1 VIT family SLATT_fungal PF18142.1 CRG85272.1 - 0.084 12.9 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain MetallophosC PF16370.5 CRG85273.1 - 0.00018 21.8 1.2 0.0002 21.6 1.2 1.1 1 0 0 1 1 1 1 C terminal of Calcineurin-like phosphoesterase ACP PF06857.11 CRG85273.1 - 0.03 14.5 0.0 0.04 14.1 0.0 1.2 1 0 0 1 1 1 0 Malonate decarboxylase delta subunit (MdcD) DUF3989 PF13150.6 CRG85273.1 - 0.054 13.2 0.1 0.071 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) TMEMspv1-c74-12 PF11044.8 CRG85273.1 - 0.054 13.5 0.5 0.054 13.5 0.5 1.7 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein SecD_SecF PF02355.16 CRG85273.1 - 0.065 12.6 0.2 0.085 12.2 0.2 1.1 1 0 0 1 1 1 0 Protein export membrane protein Brr6_like_C_C PF10104.9 CRG85273.1 - 0.071 12.9 0.1 0.1 12.4 0.1 1.2 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain AMPK1_CBM PF16561.5 CRG85275.1 - 5.3e-17 61.8 0.2 1e-16 60.9 0.2 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 CRG85275.1 - 0.018 15.4 0.1 0.038 14.4 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 CRG85275.1 - 0.086 13.4 0.3 0.19 12.3 0.3 1.5 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) cNMP_binding PF00027.29 CRG85276.1 - 2.2e-42 143.1 0.0 5.1e-22 77.7 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Methyltransf_23 PF13489.6 CRG85277.1 - 5e-17 62.2 0.0 9.3e-17 61.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85277.1 - 1.2e-08 35.5 0.0 3.6e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85277.1 - 1.1e-07 32.5 0.6 1.5e-06 28.9 0.0 2.9 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85277.1 - 9.3e-07 29.4 0.0 2.3e-06 28.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85277.1 - 3.5e-05 23.6 0.0 0.19 11.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain MTS PF05175.14 CRG85277.1 - 0.00087 18.9 0.0 0.0015 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CRG85277.1 - 0.0088 15.5 0.0 0.025 14.0 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 CRG85277.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 CRG85277.1 - 0.043 13.1 0.0 0.13 11.6 0.0 1.8 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 CRG85277.1 - 0.14 11.5 0.0 0.41 9.9 0.0 2.0 2 1 0 2 2 2 0 O-methyltransferase domain FtsJ PF01728.19 CRG85277.1 - 0.15 12.2 0.0 0.47 10.5 0.0 1.8 2 0 0 2 2 2 0 FtsJ-like methyltransferase p450 PF00067.22 CRG85278.1 - 3e-52 177.9 0.0 4.5e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Forkhead PF00250.18 CRG85280.1 - 1.3e-17 63.9 0.0 2.4e-17 63.0 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain 2OG-FeII_Oxy_3 PF13640.6 CRG85280.1 - 6.3e-10 39.8 0.1 1.5e-09 38.6 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FHA PF00498.26 CRG85280.1 - 4.3e-06 27.0 0.0 9e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 FHA domain Snf7 PF03357.21 CRG85281.1 - 1.5e-35 122.3 26.2 1.5e-35 122.3 26.2 2.0 1 1 1 2 2 2 1 Snf7 DUF3138 PF11336.8 CRG85281.1 - 4 5.9 13.8 0.63 8.6 1.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3138) Ten1 PF12658.7 CRG85282.1 - 2.2e-36 124.5 0.0 2.5e-36 124.3 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Ten1_2 PF15490.6 CRG85282.1 - 0.00097 18.8 0.0 0.0015 18.2 0.0 1.4 1 1 0 1 1 1 1 Telomere-capping, CST complex subunit MFS_1 PF07690.16 CRG85283.1 - 7e-37 127.2 40.7 2.1e-35 122.3 37.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG85283.1 - 2e-13 50.1 10.9 2e-13 50.1 10.9 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG85283.1 - 7.9e-08 31.2 3.7 7.9e-08 31.2 3.7 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CRG85283.1 - 0.14 10.5 7.4 1.3 7.3 4.4 2.2 2 0 0 2 2 2 0 Transmembrane secretion effector BCAS2 PF05700.11 CRG85284.1 - 5.1e-64 215.8 6.3 5.7e-64 215.6 6.3 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) APC1_C PF18122.1 CRG85284.1 - 0.021 14.8 0.3 0.029 14.3 0.3 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain Ceramidase_alk PF04734.13 CRG85286.1 - 4e-210 698.8 0.1 4.6e-210 698.6 0.1 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 CRG85286.1 - 1.2e-56 191.2 0.0 1.9e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Gamma_PGA_hydro PF05908.11 CRG85286.1 - 0.1 12.0 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase EI24 PF07264.11 CRG85290.1 - 5.3e-16 59.4 10.5 9e-16 58.6 10.5 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Zn_clus PF00172.18 CRG85290.1 - 0.0094 16.1 1.9 0.018 15.2 1.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GTP_EFTU PF00009.27 CRG85293.1 - 3e-32 111.7 8.2 6.8e-32 110.6 3.7 2.8 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CRG85293.1 - 1.2e-27 96.1 0.1 4.8e-27 94.2 0.1 2.1 1 0 0 1 1 1 1 Translation-initiation factor 2 IF2_N PF04760.15 CRG85293.1 - 8.3e-12 44.7 0.0 2e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region MMR_HSR1 PF01926.23 CRG85293.1 - 8.8e-11 41.9 0.0 2.7e-10 40.3 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 CRG85293.1 - 0.00018 21.0 0.0 0.00035 20.1 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CRG85293.1 - 0.00062 19.7 3.7 0.017 15.1 0.5 2.5 1 1 1 2 2 2 1 RsgA GTPase SRPRB PF09439.10 CRG85293.1 - 0.001 18.5 0.1 0.0031 17.0 0.1 1.7 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 CRG85293.1 - 0.0021 17.6 0.7 0.0079 15.7 0.7 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU_D2 PF03144.25 CRG85293.1 - 0.0099 16.2 1.1 2.5 8.6 0.1 2.8 2 0 0 2 2 2 1 Elongation factor Tu domain 2 PduV-EutP PF10662.9 CRG85293.1 - 0.03 14.1 0.2 0.11 12.3 0.2 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Roc PF08477.13 CRG85293.1 - 0.067 13.4 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CRG85293.1 - 0.78 9.8 4.9 10 6.1 0.2 3.3 3 1 1 4 4 4 0 Dynamin family Mito_carr PF00153.27 CRG85295.1 - 9.5e-59 195.3 2.5 3e-19 68.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein MFS_1 PF07690.16 CRG85298.1 - 4.9e-30 104.7 27.8 7.2e-30 104.1 27.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1430 PF07242.11 CRG85298.1 - 0.8 10.0 8.2 9.1 6.6 0.4 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1430) Ceramidase PF05875.12 CRG85299.1 - 3.9e-62 210.0 8.9 4.8e-62 209.8 8.9 1.0 1 0 0 1 1 1 1 Ceramidase MASE2 PF05230.11 CRG85299.1 - 0.022 14.8 0.3 0.022 14.8 0.3 2.1 3 0 0 3 3 3 0 MASE2 domain DUF4407 PF14362.6 CRG85299.1 - 0.15 11.4 1.3 0.26 10.6 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2070 PF09843.9 CRG85299.1 - 0.72 8.1 4.3 0.98 7.6 4.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Glyco_hydro_31 PF01055.26 CRG85300.1 - 4.8e-87 293.0 0.0 6.2e-87 292.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CRG85300.1 - 1.3e-10 41.5 0.0 3e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 CRG85300.1 - 0.045 14.0 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5110) Ribosomal_S2 PF00318.20 CRG85301.1 - 6.3e-68 228.2 0.1 6.8e-67 224.8 0.1 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 Dicty_REP PF05086.12 CRG85301.1 - 0.9 7.4 2.8 1.1 7.1 2.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 CRG85301.1 - 2.6 8.0 7.9 5.1 7.1 7.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rick_17kDa_Anti PF05433.15 CRG85302.1 - 2.1e-06 27.5 11.4 4.3e-06 26.5 11.4 1.5 1 0 0 1 1 1 1 Glycine zipper 2TM domain NmrA PF05368.13 CRG85304.1 - 3.3e-20 72.7 0.1 4.4e-20 72.2 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG85304.1 - 9e-15 55.0 0.1 3.2e-14 53.2 0.1 1.9 1 1 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG85304.1 - 1.6e-06 28.4 0.0 2.6e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG85304.1 - 2.2e-05 24.1 0.4 0.028 13.9 0.4 2.7 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 CRG85304.1 - 0.00014 21.8 0.0 0.00038 20.4 0.0 1.6 2 0 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 CRG85304.1 - 0.00017 20.7 0.3 0.00032 19.8 0.3 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 CRG85304.1 - 0.00062 20.0 0.2 0.0013 18.9 0.2 1.6 1 0 0 1 1 1 1 TrkA-N domain Glyco_trans_4_4 PF13579.6 CRG85304.1 - 0.019 15.4 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Polysacc_synt_2 PF02719.15 CRG85304.1 - 0.035 13.2 0.4 0.06 12.5 0.1 1.6 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 CRG85304.1 - 0.047 14.3 0.0 0.11 13.1 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 CRG85304.1 - 0.071 13.2 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 CRG85304.1 - 0.15 11.5 0.3 0.3 10.5 0.3 1.6 1 1 0 1 1 1 0 short chain dehydrogenase Semialdhyde_dh PF01118.24 CRG85304.1 - 0.31 11.5 0.9 1.3 9.5 0.9 1.9 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain SURF6 PF04935.12 CRG85305.1 - 3.1e-49 167.5 35.5 3.1e-49 167.5 35.5 4.3 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 CRG85305.1 - 1.5e-16 60.7 0.6 1.5e-16 60.7 0.6 8.1 6 2 0 6 6 6 2 60S ribosome biogenesis protein Rrp14 DUF2486 PF10667.9 CRG85305.1 - 0.69 10.1 27.9 0.067 13.4 21.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2486) Fer4 PF00037.27 CRG85306.1 - 9.7e-14 50.5 17.0 3.6e-08 32.9 4.1 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 CRG85306.1 - 4.6e-13 49.5 10.5 7.4e-13 48.9 10.5 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 CRG85306.1 - 1.1e-10 42.3 7.4 1.9e-05 25.5 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 CRG85306.1 - 3.5e-10 39.9 21.7 3.4e-07 30.3 12.4 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 CRG85306.1 - 5.9e-10 39.2 21.0 6e-08 32.7 11.0 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 CRG85306.1 - 1.7e-09 37.6 5.3 0.0002 21.4 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 CRG85306.1 - 1.4e-06 28.6 9.5 0.00052 20.4 1.1 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 CRG85306.1 - 1.7e-06 27.9 17.5 0.00038 20.4 5.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 CRG85306.1 - 5.1e-06 26.3 12.1 0.01 15.9 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 CRG85306.1 - 2.3e-05 24.6 11.5 0.00029 21.1 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 CRG85306.1 - 0.00014 22.4 12.3 0.024 15.2 2.1 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 CRG85306.1 - 0.011 15.9 6.0 0.34 11.1 0.2 2.2 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Fer4_18 PF13746.6 CRG85306.1 - 0.051 13.8 9.2 1.2 9.4 1.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 CRG85306.1 - 0.052 14.1 15.5 0.72 10.4 4.3 2.6 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 CRG85306.1 - 0.065 14.2 15.7 0.11 13.4 3.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 CRG85306.1 - 0.12 12.5 6.0 0.54 10.4 0.6 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 CRG85306.1 - 0.38 11.6 11.5 3.3 8.6 1.9 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain GPP34 PF05719.11 CRG85307.1 - 5.9e-65 219.1 0.1 8.7e-65 218.6 0.1 1.2 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) PP-binding PF00550.25 CRG85307.1 - 7.4e-09 35.8 0.1 1.4e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 CRG85307.1 - 4e-06 27.0 0.1 9.2e-06 25.8 0.1 1.5 1 0 0 1 1 1 1 Acyl-carrier ADH_zinc_N_2 PF13602.6 CRG85308.1 - 1.9e-09 38.7 0.0 3.1e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Exop_C PF18559.1 CRG85308.1 - 0.0038 17.1 0.0 0.0064 16.4 0.0 1.3 1 0 0 1 1 1 1 Galactose-binding domain-like ADH_zinc_N PF00107.26 CRG85308.1 - 0.033 14.2 0.1 0.061 13.3 0.1 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF2183 PF09949.9 CRG85309.1 - 4.3e-32 110.4 0.0 8.4e-32 109.5 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) APG6_N PF17675.1 CRG85310.1 - 0.0009 19.8 0.7 0.0009 19.8 0.7 1.9 2 0 0 2 2 2 1 Apg6 coiled-coil region SOGA PF11365.8 CRG85310.1 - 0.0011 20.1 2.8 4 8.6 0.0 3.7 2 1 2 4 4 4 2 Protein SOGA ADIP PF11559.8 CRG85310.1 - 0.0024 18.0 1.1 0.0024 18.0 1.1 1.8 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding Lebercilin PF15619.6 CRG85310.1 - 0.008 15.9 3.0 0.014 15.0 0.5 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease FPP PF05911.11 CRG85310.1 - 0.0084 14.4 0.3 0.01 14.1 0.3 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil DivIC PF04977.15 CRG85310.1 - 0.023 14.5 0.4 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 Septum formation initiator HMMR_N PF15905.5 CRG85310.1 - 0.026 14.0 1.1 0.047 13.2 1.1 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Cluap1 PF10234.9 CRG85310.1 - 0.032 13.7 0.5 0.049 13.0 0.5 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 TSC22 PF01166.18 CRG85310.1 - 0.24 11.8 0.2 0.24 11.8 0.2 3.2 4 0 0 4 4 4 0 TSC-22/dip/bun family DUF641 PF04859.12 CRG85310.1 - 0.98 9.8 3.6 0.54 10.6 0.7 2.0 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) ZapB PF06005.12 CRG85310.1 - 1.3 9.6 4.6 1.2 9.6 0.9 2.6 2 1 0 2 2 2 0 Cell division protein ZapB Pox_A_type_inc PF04508.12 CRG85310.1 - 3.5 7.6 0.0 3.5 7.6 0.0 4.0 4 1 1 5 5 5 0 Viral A-type inclusion protein repeat CbbQ_C PF08406.10 CRG85311.1 - 0.18 12.1 0.1 0.8 10.0 0.1 2.1 1 1 1 2 2 2 0 CbbQ/NirQ/NorQ C-terminal CBS PF00571.28 CRG85312.1 - 6.1e-19 68.2 4.0 1.2e-06 28.9 0.0 5.0 5 0 0 5 5 5 4 CBS domain PRP1_N PF06424.12 CRG85314.1 - 0.04 14.3 3.7 0.067 13.6 3.7 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DAP_B PF07930.12 CRG85314.1 - 0.16 11.9 1.0 0.27 11.2 1.0 1.3 1 0 0 1 1 1 0 D-aminopeptidase, domain B VHS PF00790.19 CRG85315.1 - 1.7e-46 157.6 0.1 1.8e-45 154.3 0.0 2.5 2 1 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 CRG85315.1 - 1e-19 70.8 0.0 2e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 CRG85315.1 - 2.3e-18 66.3 1.6 3.7e-18 65.6 0.2 2.2 2 0 0 2 2 2 1 GAT domain GGA_N-GAT PF18308.1 CRG85315.1 - 7.9e-08 31.8 0.0 2.7e-06 26.9 0.1 2.8 2 0 0 2 2 2 1 GGA N-GAT domain ERK-JNK_inhib PF15002.6 CRG85315.1 - 0.073 12.8 0.7 0.38 10.4 0.0 2.2 2 0 0 2 2 2 0 ERK and JNK pathways, inhibitor HR1 PF02185.16 CRG85315.1 - 0.19 11.9 5.2 0.28 11.3 0.5 3.4 4 0 0 4 4 4 0 Hr1 repeat DUF349 PF03993.12 CRG85315.1 - 4.8 7.6 5.6 0.99 9.7 0.1 2.6 1 1 2 3 3 3 0 Domain of Unknown Function (DUF349) Ribo_biogen_C PF04034.13 CRG85316.1 - 6.5e-52 174.6 0.0 9.1e-52 174.1 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 CRG85316.1 - 1.1e-10 41.1 0.2 1.1e-10 41.1 0.2 1.7 2 0 0 2 2 2 1 Possible Fer4-like domain in RNase L inhibitor, RLI Vfa1 PF08432.10 CRG85316.1 - 0.2 11.9 6.8 0.4 11.0 6.8 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 CRG85316.1 - 0.75 8.0 9.0 0.91 7.7 9.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 CRG85316.1 - 2 6.5 20.7 2.6 6.1 20.7 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 CRG85316.1 - 4.3 6.7 19.6 8.1 5.8 19.6 1.5 1 0 0 1 1 1 0 SDA1 CRA PF06589.11 CRG85316.1 - 4.7 7.3 8.2 1.7 8.7 5.3 1.8 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) Peptidase_C14 PF00656.22 CRG85317.1 - 1.3e-62 212.0 0.0 1.5e-62 211.7 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 CRG85317.1 - 0.07 13.1 0.6 0.31 11.0 0.0 2.4 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain Cpn60_TCP1 PF00118.24 CRG85318.1 - 2.1e-154 514.8 3.6 2.4e-154 514.6 3.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rep_fac_C PF08542.11 CRG85318.1 - 0.029 14.8 0.0 4.1 7.9 0.0 2.7 2 0 0 2 2 2 0 Replication factor C C-terminal domain Beta_helix_2 PF18835.1 CRG85318.1 - 0.15 11.8 0.0 2 8.2 0.2 2.5 2 0 0 2 2 2 0 Beta helix repeat of Inulin fructotransferase zf-H2C2 PF09337.10 CRG85320.1 - 9.8e-17 60.9 2.1 1.9e-16 59.9 2.1 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 CRG85320.1 - 6.7e-11 42.1 0.7 1.5e-10 41.0 0.7 1.6 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 CRG85320.1 - 0.00023 21.4 0.0 0.00045 20.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 CRG85320.1 - 0.0079 16.9 0.1 0.037 14.7 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CRG85320.1 - 0.045 13.9 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain LANC_like PF05147.13 CRG85321.1 - 2.5e-24 85.5 0.0 5.2e-24 84.5 0.0 1.5 1 1 0 1 1 1 1 Lanthionine synthetase C-like protein F-box-like PF12937.7 CRG85322.1 - 1.8e-06 27.7 2.6 2.1e-06 27.5 0.4 2.1 2 0 0 2 2 2 1 F-box-like F-box_5 PF18511.1 CRG85322.1 - 0.0036 16.9 0.1 0.0095 15.5 0.1 1.7 1 0 0 1 1 1 1 F-box LRR_4 PF12799.7 CRG85322.1 - 0.0042 17.5 3.9 5.9 7.5 0.0 4.6 4 1 1 6 6 6 1 Leucine Rich repeats (2 copies) F-box PF00646.33 CRG85322.1 - 0.0058 16.5 0.5 0.052 13.4 0.1 2.5 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 CRG85322.1 - 0.11 12.7 0.4 6.2 7.1 0.1 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Ribosomal_S26e PF01283.19 CRG85323.1 - 1.3e-49 167.1 3.7 1.7e-49 166.7 3.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf_CopZ PF18423.1 CRG85323.1 - 0.027 14.4 0.5 0.06 13.3 0.0 1.8 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 CRG85323.1 - 0.091 12.6 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4668) CBS PF00571.28 CRG85325.1 - 8.9e-33 112.5 3.4 1.6e-08 34.9 0.0 5.2 4 0 0 4 4 4 4 CBS domain Importin_rep_4 PF18808.1 CRG85325.1 - 1.3e-32 111.9 3.6 1.9e-31 108.2 1.2 3.9 2 1 1 3 3 3 1 Importin repeat Importin_rep_5 PF18816.1 CRG85325.1 - 1.2e-23 83.1 1.7 2.4e-23 82.2 0.4 2.4 2 0 0 2 2 1 1 Importin repeat HEAT_EZ PF13513.6 CRG85325.1 - 4.8e-21 74.8 15.5 2.3e-09 37.5 0.1 7.7 7 1 1 8 8 7 3 HEAT-like repeat HEAT PF02985.22 CRG85325.1 - 1.5e-15 55.9 3.5 0.0011 19.0 0.0 9.5 9 0 0 9 9 9 2 HEAT repeat Importin_rep_6 PF18829.1 CRG85325.1 - 3.4e-15 56.1 0.7 3e-14 53.1 0.2 2.8 2 0 0 2 2 2 1 Importin repeat 6 HEAT_2 PF13646.6 CRG85325.1 - 1.1e-14 54.6 5.2 0.00064 20.1 0.0 8.0 5 2 2 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.7 CRG85325.1 - 1.1e-10 41.9 0.1 0.0079 16.8 0.0 6.3 5 2 2 7 7 5 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 CRG85325.1 - 2.5e-09 36.8 4.5 1.1e-05 24.7 0.1 5.2 4 1 1 5 5 5 1 RNAPII transcription regulator C-terminal PB1 PF00564.24 CRG85325.1 - 8.2e-09 35.3 0.0 2.9e-08 33.5 0.0 2.0 1 0 0 1 1 1 1 PB1 domain DUF3385 PF11865.8 CRG85325.1 - 1e-06 28.7 2.3 0.046 13.6 0.2 5.4 3 3 1 5 5 5 1 Domain of unknown function (DUF3385) CLASP_N PF12348.8 CRG85325.1 - 7.6e-06 25.6 3.5 0.05 13.2 0.2 5.8 6 1 1 7 7 6 1 CLASP N terminal Cnd1 PF12717.7 CRG85325.1 - 2.1e-05 24.6 0.8 0.12 12.4 0.0 4.5 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 CRG85325.1 - 0.00043 20.1 0.3 0.028 14.2 0.1 3.1 2 1 0 3 3 2 1 rRNA processing/ribosome biogenesis Arm PF00514.23 CRG85325.1 - 0.00069 19.6 0.2 1 9.5 0.0 3.7 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat DRIM PF07539.12 CRG85325.1 - 0.0015 16.9 3.2 0.085 11.1 0.3 3.5 2 2 1 3 3 3 1 Down-regulated in metastasis RTP1_C1 PF10363.9 CRG85325.1 - 0.0021 18.2 1.0 0.29 11.3 0.4 4.4 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF4042 PF13251.6 CRG85325.1 - 0.0032 17.2 0.1 17 5.0 0.0 4.4 4 0 0 4 4 3 0 Domain of unknown function (DUF4042) UNC45-central PF11701.8 CRG85325.1 - 0.0043 17.0 7.3 2.4 8.1 0.1 4.3 4 1 0 4 4 3 2 Myosin-binding striated muscle assembly central IBN_N PF03810.19 CRG85325.1 - 0.0074 16.2 0.1 0.075 13.0 0.0 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cnd3 PF12719.7 CRG85325.1 - 0.0083 15.4 0.5 3.9 6.6 0.1 3.9 3 1 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain MMS19_N PF14500.6 CRG85325.1 - 0.015 14.9 1.4 17 4.9 0.0 4.1 4 0 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II RdRP_3 PF00998.23 CRG85325.1 - 0.031 13.0 0.0 0.055 12.2 0.0 1.3 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase DNA_alkylation PF08713.11 CRG85325.1 - 0.043 13.5 0.0 0.16 11.6 0.0 2.0 1 0 0 1 1 1 0 DNA alkylation repair enzyme V-ATPase_H_N PF03224.14 CRG85325.1 - 0.045 13.0 3.1 0.25 10.6 0.3 2.8 3 0 0 3 3 3 0 V-ATPase subunit H TFCD_C PF12612.8 CRG85325.1 - 0.061 13.1 0.1 3.7 7.4 0.0 3.0 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal PIN_2 PF10130.9 CRG85325.1 - 0.25 11.6 0.9 8 6.7 0.0 2.7 2 0 0 2 2 2 0 PIN domain Telomere_reg-2 PF10193.9 CRG85325.1 - 0.33 11.4 2.6 1.6 9.2 0.5 3.1 3 0 0 3 3 2 0 Telomere length regulation protein DUF3535 PF12054.8 CRG85325.1 - 0.36 10.0 4.4 0.54 9.4 0.2 3.2 4 1 0 4 4 3 0 Domain of unknown function (DUF3535) NmrA PF05368.13 CRG85327.1 - 1.9e-28 99.6 0.5 2.3e-28 99.3 0.5 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG85327.1 - 6.7e-12 45.7 0.1 1.1e-11 45.0 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CRG85327.1 - 0.00025 21.0 0.1 0.00053 19.9 0.1 1.5 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CRG85327.1 - 0.0004 19.5 0.3 0.00075 18.6 0.3 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 CRG85327.1 - 0.00077 19.9 0.2 0.0017 18.8 0.2 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG85327.1 - 0.00077 18.7 0.3 0.0012 18.1 0.3 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CRG85327.1 - 0.002 18.4 0.1 0.0049 17.1 0.1 1.8 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG85327.1 - 0.0077 15.7 0.2 0.015 14.8 0.1 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CRG85327.1 - 0.029 14.5 0.1 0.054 13.6 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GDP_Man_Dehyd PF16363.5 CRG85327.1 - 0.043 13.2 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Fe-ADH PF00465.19 CRG85328.1 - 3.6e-73 246.5 0.0 4.4e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CRG85328.1 - 1e-10 41.8 0.1 4.1e-05 23.4 0.4 2.1 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase baeRF_family10 PF18854.1 CRG85328.1 - 0.17 12.2 0.1 0.31 11.3 0.1 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 Aconitase PF00330.20 CRG85329.1 - 5.5e-145 483.9 0.0 7.3e-145 483.5 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CRG85329.1 - 2.1e-39 134.8 0.0 3.3e-39 134.2 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF2408 PF10303.9 CRG85330.1 - 2.1e-46 157.8 6.2 2.2e-29 102.8 1.9 4.9 3 2 1 4 4 4 4 Protein of unknown function (DUF2408) Ribosomal_60s PF00428.19 CRG85331.1 - 6.9e-27 93.9 11.7 8.4e-27 93.6 11.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 CRG85331.1 - 0.34 11.4 2.6 0.61 10.5 0.2 2.0 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) DUF3824 PF12868.7 CRG85331.1 - 6.1 7.5 6.7 8.4 7.0 6.7 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) PQ-loop PF04193.14 CRG85333.1 - 1.4e-40 136.8 4.9 1.1e-20 73.1 0.1 2.7 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 CRG85333.1 - 0.016 15.2 0.5 0.054 13.5 0.0 2.0 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange ER_lumen_recept PF00810.18 CRG85333.1 - 0.11 13.3 0.4 7.2 7.4 0.0 2.6 2 1 1 3 3 3 0 ER lumen protein retaining receptor Tcf25 PF04910.14 CRG85334.1 - 1.2e-77 261.4 0.0 1.7e-77 260.9 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_12 PF13424.6 CRG85334.1 - 0.00015 22.0 0.4 0.26 11.6 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG85334.1 - 0.065 13.4 0.0 2.6 8.4 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG85334.1 - 0.47 11.4 4.8 4 8.5 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF2894 PF11445.8 CRG85334.1 - 6.4 7.2 10.9 16 5.9 10.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) Stm1_N PF09598.10 CRG85334.1 - 7.7 7.5 17.3 1.1 10.1 11.6 2.4 1 1 1 2 2 2 0 Stm1 PP2C PF00481.21 CRG85335.1 - 3.3e-42 144.9 0.0 7.2e-42 143.8 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CRG85335.1 - 1.4e-05 24.9 0.0 2.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 CRG85335.1 - 0.00094 19.1 0.0 2.2 8.2 0.0 3.1 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) 60KD_IMP PF02096.20 CRG85336.1 - 2e-10 40.9 0.2 1.5e-09 38.0 0.2 2.0 1 1 0 1 1 1 1 60Kd inner membrane protein UPF0715 PF17094.5 CRG85336.1 - 0.095 13.3 0.9 0.29 11.7 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0715) ALG11_N PF15924.5 CRG85337.1 - 1.7e-81 273.3 0.1 2.3e-81 272.9 0.1 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 CRG85337.1 - 1.3e-19 70.4 0.0 2.7e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG85337.1 - 2.9e-08 34.2 0.0 9.2e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 AAA_5 PF07728.14 CRG85337.1 - 0.012 15.7 0.0 0.033 14.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Glyco_transf_4 PF13439.6 CRG85337.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 Glycosyltransferase Family 4 zf-C2H2 PF00096.26 CRG85338.1 - 9.6e-13 47.8 12.0 3.8e-06 27.0 2.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG85338.1 - 7.5e-12 45.1 10.9 2e-07 31.1 0.2 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG85338.1 - 1e-08 35.3 10.4 0.00043 20.9 1.5 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CRG85338.1 - 3.6e-08 33.2 5.4 0.00034 20.5 0.3 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG85338.1 - 3.1e-06 27.3 0.4 0.093 13.1 0.1 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG85338.1 - 3.4e-05 24.1 0.8 0.014 15.8 0.2 3.3 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CRG85338.1 - 0.0065 16.2 4.8 0.43 10.4 0.7 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-Di19 PF05605.12 CRG85338.1 - 0.083 13.2 1.4 0.19 12.1 1.4 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_recom PF13408.6 CRG85338.1 - 0.088 13.3 1.0 0.21 12.1 1.0 1.6 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain zf-C2HE PF16278.5 CRG85338.1 - 0.15 12.5 2.2 4.3 7.9 0.4 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger LIM PF00412.22 CRG85338.1 - 0.76 10.1 3.1 17 5.8 1.8 2.4 1 1 1 2 2 2 0 LIM domain SUIM_assoc PF16619.5 CRG85338.1 - 1.2 9.3 15.7 0.028 14.5 3.6 3.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 CRG85339.1 - 6e-54 183.2 0.1 3.3e-36 125.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85339.1 - 1.1e-25 90.4 0.0 6e-24 84.7 0.0 3.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG85339.1 - 4.1e-05 22.5 0.0 0.00014 20.8 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CRG85339.1 - 4.7e-05 22.9 0.0 0.00015 21.2 0.0 1.8 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 CRG85339.1 - 0.00058 19.8 0.1 0.0041 17.1 0.1 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kelch_6 PF13964.6 CRG85341.1 - 1.9e-05 24.8 4.0 0.33 11.3 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 CRG85341.1 - 0.0004 20.3 10.8 0.19 11.8 0.1 4.4 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 CRG85341.1 - 0.00086 19.5 19.4 0.053 13.8 1.4 5.1 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 CRG85341.1 - 0.0011 18.9 0.6 0.038 14.0 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 CRG85341.1 - 0.022 14.7 1.5 4.9 7.3 0.1 4.0 3 1 0 3 3 3 0 Kelch motif BPL_LplA_LipB PF03099.19 CRG85342.1 - 1.5e-06 28.1 0.0 5.9e-06 26.2 0.0 2.0 2 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family Chorismate_synt PF01264.21 CRG85343.1 - 7.9e-141 468.5 0.0 9e-141 468.3 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase Ima1_N PF09779.9 CRG85344.1 - 1.5e-33 116.5 6.4 3.9e-33 115.2 6.4 1.8 1 0 0 1 1 1 1 Ima1 N-terminal domain DZR PF12773.7 CRG85344.1 - 0.015 15.3 4.8 0.81 9.8 0.7 2.5 2 0 0 2 2 2 0 Double zinc ribbon FYVE PF01363.21 CRG85344.1 - 0.044 13.9 1.5 1.2 9.4 0.2 2.4 2 0 0 2 2 2 0 FYVE zinc finger OrfB_Zn_ribbon PF07282.11 CRG85344.1 - 0.39 10.7 6.4 0.082 12.8 1.4 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain adh_short_C2 PF13561.6 CRG85345.1 - 1.9e-43 148.7 1.6 2.3e-43 148.4 1.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG85345.1 - 2.2e-34 118.6 0.5 3.8e-34 117.9 0.5 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Alg14 PF08660.11 CRG85345.1 - 1.5e-29 103.2 0.0 6.1e-29 101.2 0.0 2.0 1 1 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like KR PF08659.10 CRG85345.1 - 2.4e-07 30.9 0.8 3.8e-07 30.2 0.8 1.2 1 0 0 1 1 1 1 KR domain Formyl_trans_N PF00551.19 CRG85347.1 - 2.4e-23 82.8 0.0 3.8e-23 82.2 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 CRG85347.1 - 0.015 15.5 0.7 0.17 12.2 0.7 2.4 2 1 0 2 2 2 0 Formyl transferase, C-terminal domain DUF1712 PF08217.11 CRG85348.1 - 1.8e-15 56.5 0.0 1.5e-14 53.5 0.0 2.3 2 1 0 2 2 2 1 Fungal domain of unknown function (DUF1712) TFIIA PF03153.13 CRG85348.1 - 0.006 16.6 8.9 0.47 10.4 2.7 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit CFIA_Pcf11 PF11526.8 CRG85348.1 - 5.2 7.6 8.4 0.91 10.0 2.4 2.9 3 0 0 3 3 3 0 Subunit of cleavage factor IA Pcf11 Pex14_N PF04695.13 CRG85348.1 - 7.2 7.2 13.6 4.8 7.8 3.0 3.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ras PF00071.22 CRG85350.1 - 5.7e-56 188.6 0.0 6.7e-56 188.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG85350.1 - 4.2e-22 78.6 0.0 6.2e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG85350.1 - 1.1e-07 31.5 0.0 1.9e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG85350.1 - 0.00046 19.8 0.1 0.0012 18.4 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CRG85350.1 - 0.0019 17.7 0.0 0.0025 17.3 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CRG85350.1 - 0.072 12.4 0.0 0.083 12.2 0.0 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CRG85350.1 - 0.097 12.6 0.1 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase KOW PF00467.29 CRG85351.1 - 0.00013 21.8 0.7 0.00023 21.0 0.7 1.4 1 0 0 1 1 1 1 KOW motif CusF_Ec PF11604.8 CRG85351.1 - 0.073 13.1 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF MHB PF16525.5 CRG85351.1 - 4.5 7.6 6.4 3.7 7.9 1.0 2.5 2 0 0 2 2 2 0 Haemophore, haem-binding Rtt106 PF08512.12 CRG85353.1 - 4e-32 110.5 0.0 2.3e-31 108.1 0.0 2.1 2 1 0 2 2 2 1 Histone chaperone Rttp106-like PH_18 PF18469.1 CRG85353.1 - 0.0044 17.0 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Pkinase PF00069.25 CRG85355.1 - 3.4e-27 95.5 0.0 4.1e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85355.1 - 3.5e-14 52.7 0.0 4.5e-14 52.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG85355.1 - 4.8e-07 28.9 0.0 6.8e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase NmrA PF05368.13 CRG85360.1 - 4.3e-24 85.4 0.0 7.1e-24 84.6 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG85360.1 - 6.2e-18 65.3 0.0 8.4e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG85360.1 - 2e-05 24.2 0.1 0.072 12.5 0.1 3.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CRG85360.1 - 0.00014 22.1 0.0 0.00027 21.2 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CRG85360.1 - 0.0056 17.1 0.3 0.013 16.0 0.1 1.7 2 0 0 2 2 2 1 Putative NAD(P)-binding DapB_N PF01113.20 CRG85360.1 - 0.017 15.3 0.1 0.035 14.2 0.1 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RGS PF00615.19 CRG85362.1 - 1.2e-10 41.7 0.0 1.8e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF647 PF04884.14 CRG85363.1 - 5.8e-89 297.9 8.8 3.7e-87 292.0 8.8 2.1 1 1 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis S36_mt PF10937.8 CRG85364.1 - 2.9e-42 144.9 0.4 3.3e-42 144.7 0.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial PNK3P PF08645.11 CRG85366.1 - 6.7e-56 188.5 0.0 1.2e-55 187.6 0.0 1.5 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase Med18 PF09637.10 CRG85366.1 - 8.6e-48 163.3 0.0 1.9e-47 162.2 0.0 1.5 1 0 0 1 1 1 1 Med18 protein AAA_33 PF13671.6 CRG85366.1 - 6.3e-28 97.7 0.0 1.6e-25 89.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 CRG85366.1 - 0.0006 19.4 0.4 0.8 9.1 0.0 2.8 2 1 0 3 3 3 2 Chromatin associated protein KTI12 EMP24_GP25L PF01105.24 CRG85369.1 - 1.5e-50 171.7 0.1 1.7e-50 171.5 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GspH PF12019.8 CRG85369.1 - 0.1 13.1 0.6 0.18 12.2 0.4 1.5 1 1 0 1 1 1 0 Type II transport protein GspH CarboxypepD_reg PF13620.6 CRG85369.1 - 0.15 12.3 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain DUF2721 PF11026.8 CRG85369.1 - 0.41 10.5 2.7 0.17 11.8 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) SANT_DAMP1_like PF16282.5 CRG85371.1 - 6.5e-31 106.4 1.5 1.4e-30 105.3 1.5 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 CRG85371.1 - 0.0001 22.2 4.0 0.0001 22.2 4.0 3.2 2 1 1 3 3 3 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-binding PF00249.31 CRG85371.1 - 0.0075 16.4 0.1 0.086 13.0 0.1 2.6 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG85371.1 - 0.028 14.7 0.0 0.11 12.8 0.0 2.1 2 1 0 2 2 2 0 Myb-like DNA-binding domain Ufd2P_core PF10408.9 CRG85375.1 - 2.3e-220 733.4 9.2 2.9e-220 733.1 9.2 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 CRG85375.1 - 4.4e-19 68.4 2.9 5.9e-19 68.0 0.5 2.5 2 0 0 2 2 2 1 U-box domain Steroid_dh PF02544.16 CRG85375.1 - 4.2e-10 39.8 2.2 0.0055 16.7 0.5 3.8 3 0 0 3 3 3 3 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 CRG85375.1 - 0.0024 17.5 2.3 0.0027 17.3 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) adh_short PF00106.25 CRG85376.1 - 2.6e-31 108.6 0.4 4.3e-31 107.9 0.4 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85376.1 - 2e-22 79.9 0.2 8.2e-22 77.9 0.2 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Fungal_trans PF04082.18 CRG85376.1 - 8.2e-15 54.5 0.0 1.2e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain KR PF08659.10 CRG85376.1 - 1.9e-09 37.7 0.0 4.1e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG85376.1 - 0.024 14.1 0.1 0.43 10.0 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Transglut_core2 PF13369.6 CRG85376.1 - 0.032 13.8 0.0 0.086 12.4 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase-like superfamily Polysacc_synt_2 PF02719.15 CRG85376.1 - 0.059 12.5 0.1 0.094 11.8 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF4349 PF14257.6 CRG85376.1 - 0.19 11.2 0.3 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) adh_short PF00106.25 CRG85377.1 - 3.7e-22 78.7 0.0 1.8e-18 66.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85377.1 - 1.6e-12 47.5 0.0 3.4e-11 43.2 0.0 2.1 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85377.1 - 2.1e-06 27.8 0.1 4.2e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 KR domain DUF1977 PF09320.11 CRG85378.1 - 5.8e-32 110.1 0.1 1e-31 109.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 CRG85378.1 - 3.8e-22 78.2 0.2 7e-22 77.3 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain Aim19 PF10315.9 CRG85380.1 - 0.002 18.4 0.3 0.0021 18.3 0.3 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 DUF4536 PF15055.6 CRG85380.1 - 0.064 13.5 0.2 0.12 12.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) CTP_transf_like PF01467.26 CRG85382.1 - 0.0019 18.4 0.0 0.0045 17.2 0.0 1.7 2 0 0 2 2 2 1 Cytidylyltransferase-like Tcp11 PF05794.13 CRG85386.1 - 5.2e-96 322.4 0.7 9.6e-96 321.5 0.1 1.8 2 0 0 2 2 2 1 T-complex protein 11 Ydc2-catalyt PF09159.10 CRG85386.1 - 2.2e-73 247.4 0.2 3.8e-73 246.7 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Pox_A22 PF04848.13 CRG85386.1 - 0.0011 19.1 0.0 6.5 6.9 0.0 3.9 4 0 0 4 4 4 2 Poxvirus A22 protein SOG2 PF10428.9 CRG85387.1 - 3.4e-102 343.3 0.0 9.6e-52 176.8 0.1 4.4 4 1 1 5 5 5 2 RAM signalling pathway protein LRR_8 PF13855.6 CRG85387.1 - 5.1e-14 51.8 2.8 5.3e-08 32.5 0.4 2.6 1 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 CRG85387.1 - 4e-11 43.0 2.8 5.7e-05 23.4 0.3 3.5 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CRG85387.1 - 0.0033 17.8 3.5 33 5.6 0.1 5.2 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 CRG85387.1 - 4 7.7 6.3 19 5.6 0.1 4.2 5 0 0 5 5 5 0 Leucine Rich repeat Cupin_2 PF07883.11 CRG85388.1 - 1.2e-07 31.4 0.0 2e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CRG85388.1 - 2.3e-05 24.0 0.0 3.6e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF861) adh_short PF00106.25 CRG85390.1 - 2.4e-14 53.2 0.2 3.2e-14 52.9 0.2 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85390.1 - 1.9e-09 37.4 0.3 2.3e-09 37.2 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85390.1 - 2e-07 31.1 0.3 3.4e-07 30.3 0.1 1.4 2 0 0 2 2 2 1 KR domain NmrA PF05368.13 CRG85390.1 - 5e-06 26.2 2.6 8.4e-06 25.5 2.6 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG85390.1 - 3.7e-05 23.7 0.5 6.3e-05 23.0 0.5 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG85390.1 - 0.00039 19.9 0.0 0.00063 19.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CRG85390.1 - 0.00046 19.7 0.4 0.0015 18.1 0.2 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 CRG85390.1 - 0.027 15.1 0.2 0.066 13.8 0.2 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 CRG85390.1 - 0.062 13.8 1.6 0.22 12.0 1.6 2.0 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CRG85390.1 - 0.21 11.7 2.7 0.25 11.5 0.8 1.9 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus MRP-S25 PF13741.6 CRG85391.1 - 9.7e-82 274.0 3.6 1.1e-81 273.8 3.6 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 CRG85391.1 - 0.047 14.0 1.3 1.5 9.1 0.0 2.8 3 0 0 3 3 3 0 Mitochondrial ribosomal protein S23 PPR_2 PF13041.6 CRG85394.1 - 2e-05 24.7 0.1 1.5 9.0 0.0 4.8 4 1 1 5 5 5 2 PPR repeat family PPR_long PF17177.4 CRG85394.1 - 0.0012 18.3 0.0 0.0047 16.3 0.0 1.8 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP Methyltransf_23 PF13489.6 CRG85398.1 - 1.7e-19 70.3 0.0 2.5e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85398.1 - 5.4e-11 43.1 0.0 1.4e-10 41.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85398.1 - 2e-07 30.9 0.0 0.0089 15.8 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85398.1 - 8.9e-07 29.5 0.0 1.7e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85398.1 - 4.5e-06 27.3 0.0 2.6e-05 24.9 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG85398.1 - 0.025 14.0 0.1 0.079 12.4 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase PrmA PF06325.13 CRG85398.1 - 0.042 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CRG85398.1 - 0.054 13.1 0.0 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 CRG85398.1 - 0.08 12.7 0.0 0.19 11.4 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase CMAS PF02353.20 CRG85398.1 - 0.09 12.0 0.0 0.16 11.2 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 CRG85398.1 - 0.093 12.0 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain DUF938 PF06080.12 CRG85398.1 - 0.12 12.1 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 CRG85398.1 - 0.18 11.1 0.0 0.84 8.9 0.0 2.1 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family Helicase_C PF00271.31 CRG85399.1 - 1.5e-17 63.9 0.0 7.2e-13 48.9 0.0 2.7 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 CRG85399.1 - 7.3e-17 61.7 0.0 3.5e-16 59.5 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 CRG85399.1 - 1.3e-06 29.0 0.8 2.9e-06 27.9 0.8 1.6 1 0 0 1 1 1 1 RecQ zinc-binding HTH_DeoR PF08220.12 CRG85399.1 - 0.31 10.8 1.1 0.46 10.3 0.1 1.8 2 0 0 2 2 2 0 DeoR-like helix-turn-helix domain KH_1 PF00013.29 CRG85401.1 - 3.2e-11 42.9 0.0 9.3e-08 31.8 0.0 2.8 2 0 0 2 2 2 2 KH domain ALS_ss_C PF10369.9 CRG85403.1 - 1.6e-15 57.0 0.0 4.4e-14 52.4 0.0 2.5 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 CRG85403.1 - 4.4e-12 45.5 0.2 9.4e-12 44.5 0.2 1.6 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 CRG85403.1 - 6.9e-10 38.6 0.1 1.4e-07 31.3 0.0 2.3 2 0 0 2 2 2 2 ACT domain Limkain-b1 PF11608.8 CRG85403.1 - 0.01 15.9 0.0 0.03 14.4 0.0 1.7 2 0 0 2 2 2 0 Limkain b1 ACT_6 PF13740.6 CRG85403.1 - 0.037 14.0 0.1 7.8 6.6 0.0 2.6 2 0 0 2 2 2 0 ACT domain MEIOC PF15189.6 CRG85403.1 - 0.11 12.0 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Meiosis-specific coiled-coil domain-containing protein MEIOC DUF3712 PF12505.8 CRG85405.1 - 2.1e-07 31.2 0.2 1.4e-06 28.6 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) LEA_2 PF03168.13 CRG85405.1 - 9.3e-07 29.3 2.1 0.11 13.0 0.1 4.4 5 0 0 5 5 5 2 Late embryogenesis abundant protein GMC_oxred_N PF00732.19 CRG85408.1 - 1e-58 199.1 0.0 1.6e-58 198.4 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase p450 PF00067.22 CRG85408.1 - 5.3e-54 183.7 0.0 7.8e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 GMC_oxred_C PF05199.13 CRG85408.1 - 3.2e-35 121.7 0.0 7.1e-35 120.6 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Fungal_trans PF04082.18 CRG85408.1 - 8.1e-15 54.6 0.2 4.5e-14 52.1 0.0 2.1 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85408.1 - 3e-07 30.4 13.1 6.9e-07 29.3 13.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAD_binding_2 PF00890.24 CRG85408.1 - 4.2e-05 22.8 0.2 0.11 11.5 0.2 2.3 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CRG85408.1 - 0.00017 20.9 0.2 0.00031 20.1 0.2 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CRG85408.1 - 0.00083 18.5 0.4 0.0015 17.6 0.4 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CRG85408.1 - 0.00089 18.9 0.3 0.0056 16.3 0.4 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG85408.1 - 0.0036 17.5 0.2 0.025 14.8 0.2 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG85408.1 - 0.017 14.3 0.0 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG85408.1 - 0.11 12.5 0.3 0.93 9.5 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 CRG85408.1 - 0.13 11.1 0.5 0.2 10.5 0.5 1.2 1 0 0 1 1 1 0 Tryptophan halogenase OTCace_N PF02729.21 CRG85409.1 - 2.1e-46 157.6 0.0 3.2e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 CRG85409.1 - 6.3e-44 149.8 0.0 9.4e-44 149.3 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Bac_rhamnosid PF05592.11 CRG85409.1 - 0.15 12.0 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain DUF3984 PF13136.6 CRG85410.1 - 3.6e-88 296.2 23.0 5.8e-88 295.5 23.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3984) FAD_binding_3 PF01494.19 CRG85410.1 - 1.2e-13 51.1 0.1 8.4e-13 48.3 0.1 2.1 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CRG85410.1 - 0.0065 16.5 0.0 0.018 15.0 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CRG85410.1 - 0.2 10.8 1.1 1.4 8.1 0.3 2.0 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_23 PF13489.6 CRG85412.1 - 6.9e-23 81.3 0.0 3.4e-22 79.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85412.1 - 8.7e-09 36.0 0.0 1.2e-07 32.3 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85412.1 - 3.5e-06 27.6 0.0 0.00016 22.2 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85412.1 - 4.3e-06 26.6 0.0 0.095 12.5 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85412.1 - 9e-06 26.4 0.0 0.0013 19.5 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_16 PF10294.9 CRG85412.1 - 0.048 13.4 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase MTS PF05175.14 CRG85412.1 - 0.052 13.1 0.0 0.15 11.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CRG85412.1 - 0.16 11.4 0.0 0.47 9.9 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Cut8 PF08559.10 CRG85414.1 - 3.9e-77 259.1 0.0 4.7e-77 258.8 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein rRNA_proc-arch PF13234.6 CRG85416.1 - 7.8e-88 294.9 0.2 2e-87 293.6 0.0 1.8 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 CRG85416.1 - 1.8e-55 187.1 2.4 4.5e-55 185.8 2.4 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 CRG85416.1 - 1.9e-18 66.9 0.3 2.3e-17 63.3 0.0 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG85416.1 - 6.5e-07 29.7 0.0 2.1e-06 28.1 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG85416.1 - 4.5e-05 23.5 0.0 0.00012 22.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 CRG85416.1 - 0.013 14.6 0.0 0.039 13.0 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 CRG85416.1 - 0.075 13.3 0.0 0.41 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF5388 PF17363.2 CRG85416.1 - 0.17 12.1 1.1 0.56 10.4 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5388) IKI3 PF04762.12 CRG85418.1 - 0 1018.0 0.0 0 1017.7 0.0 1.0 1 0 0 1 1 1 1 IKI3 family COX7C PF02935.16 CRG85418.1 - 2.5e-19 69.3 2.3 6.5e-19 68.0 2.3 1.8 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc ANAPC4_WD40 PF12894.7 CRG85418.1 - 0.0053 17.0 0.5 4.8 7.6 0.0 4.6 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain DHR-2 PF06920.13 CRG85418.1 - 0.011 14.4 1.4 0.02 13.6 1.4 1.3 1 0 0 1 1 1 0 Dock homology region 2 Gmad1 PF10647.9 CRG85418.1 - 0.066 12.9 0.0 2.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain MDD_C PF18376.1 CRG85419.1 - 6.4e-63 211.9 0.0 8.8e-63 211.4 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 CRG85419.1 - 6.5e-10 39.1 1.0 2e-09 37.6 1.0 1.8 2 0 0 2 2 2 1 GHMP kinases N terminal domain Cyto_heme_lyase PF01265.17 CRG85420.1 - 2.9e-35 122.3 0.4 6.2e-32 111.4 0.0 3.2 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase Asp PF00026.23 CRG85421.1 - 5.2e-70 236.4 7.3 6.3e-70 236.1 7.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG85421.1 - 1.3e-11 45.1 6.7 3.6e-09 37.1 5.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG85421.1 - 0.0014 19.2 0.4 0.31 11.7 0.0 3.4 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.6 CRG85421.1 - 0.015 15.1 0.0 0.33 10.7 0.0 2.3 1 1 1 2 2 2 0 Xylanase inhibitor C-terminal 4HBT PF03061.22 CRG85422.1 - 0.0033 17.7 0.2 0.41 11.0 0.1 2.5 2 0 0 2 2 2 2 Thioesterase superfamily Vfa1 PF08432.10 CRG85423.1 - 3.1e-61 206.9 21.2 3.5e-61 206.7 21.2 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 CRG85423.1 - 0.0023 17.8 15.2 0.0032 17.3 15.2 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 TAF4 PF05236.14 CRG85423.1 - 0.005 16.6 14.4 0.0058 16.4 14.4 1.1 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family MTBP_N PF14918.6 CRG85423.1 - 0.014 14.9 0.5 0.014 14.9 0.5 1.8 1 1 1 2 2 2 0 MDM2-binding NPR3 PF03666.13 CRG85423.1 - 0.064 12.0 14.3 0.073 11.9 14.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 CRG85423.1 - 0.13 11.3 5.5 0.14 11.1 5.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF262 PF03235.14 CRG85423.1 - 0.13 12.4 9.0 0.15 12.3 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 DDHD PF02862.17 CRG85423.1 - 0.13 12.4 5.8 0.16 12.1 5.8 1.1 1 0 0 1 1 1 0 DDHD domain Tim54 PF11711.8 CRG85423.1 - 0.13 11.0 11.9 0.2 10.4 11.9 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Rrn6 PF10214.9 CRG85423.1 - 0.19 10.2 6.3 0.19 10.2 6.3 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF908 PF06012.12 CRG85423.1 - 0.24 10.8 2.4 0.25 10.7 2.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SLC12 PF03522.15 CRG85423.1 - 0.35 9.8 12.1 0.41 9.6 12.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PPL5 PF18168.1 CRG85423.1 - 0.46 9.7 10.9 0.58 9.4 10.9 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Presenilin PF01080.17 CRG85423.1 - 0.61 8.8 12.3 0.74 8.5 12.3 1.1 1 0 0 1 1 1 0 Presenilin MCM_bind PF09739.9 CRG85423.1 - 0.75 8.2 13.7 0.88 7.9 13.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SAPS PF04499.15 CRG85423.1 - 0.89 8.3 13.4 1 8.0 13.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC27 PF09507.10 CRG85423.1 - 1.1 8.6 27.4 1.4 8.3 27.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 CRG85423.1 - 1.5 7.1 21.0 1.6 6.9 21.0 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF87 PF01935.17 CRG85423.1 - 1.9 8.5 8.1 2.4 8.2 8.1 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain SID-1_RNA_chan PF13965.6 CRG85423.1 - 1.9 6.8 3.7 2.1 6.7 3.7 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF5401 PF17380.2 CRG85423.1 - 2.5 6.1 21.1 3 5.8 21.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Neur_chan_memb PF02932.16 CRG85423.1 - 4 7.4 6.2 4.6 7.2 6.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Borrelia_P83 PF05262.11 CRG85423.1 - 4.5 5.6 26.9 5.7 5.3 26.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein U79_P34 PF03064.16 CRG85423.1 - 4.6 6.5 28.6 6.9 6.0 28.6 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DASH_Spc19 PF08287.11 CRG85423.1 - 4.7 7.1 20.7 6.7 6.6 20.7 1.2 1 0 0 1 1 1 0 Spc19 FAM60A PF15396.6 CRG85423.1 - 5.6 6.9 18.8 0.69 9.9 14.9 1.5 2 0 0 2 2 2 0 Protein Family FAM60A Hid1 PF12722.7 CRG85423.1 - 6.7 4.7 11.2 7.7 4.5 11.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2828 PF11443.8 CRG85423.1 - 6.9 4.6 15.6 8.3 4.4 15.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4746 PF15928.5 CRG85423.1 - 7.4 5.9 20.1 9.7 5.5 20.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 CRG85423.1 - 8 5.3 4.9 8.8 5.1 4.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) NARP1 PF12569.8 CRG85423.1 - 8.8 5.1 25.5 10 4.9 25.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Paramyxo_ncap PF00973.19 CRG85423.1 - 9 5.1 13.6 11 4.7 13.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SUFU_C PF12470.8 CRG85423.1 - 9.1 6.3 8.4 12 5.9 8.4 1.2 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain DSPc PF00782.20 CRG85424.1 - 4.9e-25 87.9 0.0 7.3e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CRG85424.1 - 0.0048 17.2 0.0 0.0096 16.2 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain DUF674 PF05056.12 CRG85424.1 - 0.078 11.8 0.0 4.4 6.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF674) zf-C2H2 PF00096.26 CRG85426.1 - 0.0025 18.2 22.0 0.026 15.0 1.6 5.2 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-FCS PF06467.14 CRG85426.1 - 0.079 12.9 3.4 4 7.4 0.2 2.8 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_jaz PF12171.8 CRG85426.1 - 0.081 13.2 15.9 0.27 11.6 4.6 4.2 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-CHCC PF10276.9 CRG85426.1 - 0.17 12.0 4.9 6.7 6.9 0.4 2.7 2 0 0 2 2 2 0 Zinc-finger domain PyrI_C PF02748.15 CRG85426.1 - 0.22 11.4 4.1 4.6 7.2 2.8 2.5 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn_ribbon_SprT PF17283.2 CRG85426.1 - 0.37 10.7 7.8 0.58 10.1 4.0 2.9 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zf-BED PF02892.15 CRG85426.1 - 1.2 9.2 8.8 2.8 8.0 0.9 3.8 3 0 0 3 3 3 0 BED zinc finger zf-C2H2_4 PF13894.6 CRG85426.1 - 1.5 9.8 25.1 0.58 11.2 1.8 5.6 5 0 0 5 5 5 0 C2H2-type zinc finger HNH_5 PF14279.6 CRG85426.1 - 6.6 6.7 7.3 3.9 7.4 1.2 3.3 3 0 0 3 3 3 0 HNH endonuclease Ndc1_Nup PF09531.10 CRG85427.1 - 1.8e-159 532.3 0.3 2e-159 532.1 0.3 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Syntaxin_2 PF14523.6 CRG85428.1 - 3.5e-27 94.7 2.2 3.5e-27 94.7 2.2 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 CRG85428.1 - 2.3e-15 56.3 1.7 2.3e-15 56.3 1.7 2.1 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 CRG85428.1 - 4.2e-05 23.3 10.9 0.00015 21.5 10.9 2.0 1 1 0 1 1 1 1 Syntaxin Synaptobrevin PF00957.21 CRG85428.1 - 0.0006 19.6 0.3 0.0023 17.7 0.3 2.0 2 0 0 2 2 2 1 Synaptobrevin DUF883 PF05957.13 CRG85428.1 - 0.0053 17.3 7.8 0.015 15.9 0.1 3.1 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF883) Prominin PF05478.11 CRG85428.1 - 0.13 10.1 4.4 0.2 9.6 4.4 1.4 1 1 0 1 1 1 0 Prominin DUF1664 PF07889.12 CRG85428.1 - 1.1 9.3 6.0 16 5.5 1.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CEP209_CC5 PF16574.5 CRG85428.1 - 2 8.6 11.1 1.9 8.6 7.6 2.3 1 1 2 3 3 3 0 Coiled-coil region of centrosome protein CE290 LPP PF04728.13 CRG85428.1 - 2.3 8.6 5.6 5.6 7.4 0.1 3.5 3 1 0 3 3 3 0 Lipoprotein leucine-zipper FUSC PF04632.12 CRG85428.1 - 8.5 4.8 7.4 11 4.4 2.5 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family SAP PF02037.27 CRG85430.1 - 1.2e-10 40.9 0.1 2.2e-10 40.1 0.1 1.5 1 0 0 1 1 1 1 SAP domain ADH_zinc_N PF00107.26 CRG85431.1 - 0.033 14.2 0.0 0.063 13.3 0.0 1.5 1 1 0 1 1 1 0 Zinc-binding dehydrogenase MFS_1 PF07690.16 CRG85432.1 - 1.5e-41 142.5 59.3 3.5e-39 134.7 59.9 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TPK_B1_binding PF04265.14 CRG85432.1 - 0.021 14.5 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain p450 PF00067.22 CRG85433.1 - 3.1e-21 75.7 0.0 3.5e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ank_2 PF12796.7 CRG85434.1 - 7.9e-10 39.2 0.0 0.0017 18.9 0.0 4.3 3 2 2 5 5 5 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG85434.1 - 3e-06 27.7 0.1 0.52 11.0 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG85434.1 - 8.8e-06 25.9 0.0 0.0045 17.4 0.0 4.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 CRG85434.1 - 0.0004 20.6 0.0 0.021 15.2 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Helo_like_N PF17111.5 CRG85434.1 - 0.00058 19.3 0.2 0.0014 18.0 0.1 1.7 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins Chlamy_scaf PF09675.10 CRG85434.1 - 0.026 14.9 0.0 0.17 12.2 0.1 2.2 2 0 0 2 2 2 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) Filament PF00038.21 CRG85434.1 - 0.14 11.7 0.6 3 7.4 0.0 2.2 2 0 0 2 2 2 0 Intermediate filament protein DHC_N1 PF08385.12 CRG85434.1 - 0.18 10.4 0.2 2.1 6.9 0.0 2.1 2 0 0 2 2 2 0 Dynein heavy chain, N-terminal region 1 FMN_dh PF01070.18 CRG85435.1 - 3.3e-103 345.4 0.0 4.2e-103 345.0 0.0 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG85435.1 - 5.3e-20 71.4 0.0 9.8e-20 70.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CRG85435.1 - 6.9e-06 25.4 0.0 1.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 CRG85435.1 - 0.00031 20.1 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 CRG85435.1 - 0.00075 18.6 0.0 0.0014 17.7 0.0 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CRG85435.1 - 0.034 13.6 0.1 0.11 11.9 0.1 1.7 1 1 1 2 2 2 0 Nitronate monooxygenase B2-adapt-app_C PF09066.10 CRG85435.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain TatD_DNase PF01026.21 CRG85436.1 - 9.6e-53 179.2 0.0 1.2e-52 178.9 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Aa_trans PF01490.18 CRG85438.1 - 9e-78 261.8 30.1 1.1e-77 261.5 30.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Rad52_Rad22 PF04098.15 CRG85441.1 - 6.9e-60 201.4 0.0 9.7e-60 200.9 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein UBA PF00627.31 CRG85442.1 - 0.00058 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain UBX PF00789.20 CRG85442.1 - 0.00075 19.7 0.0 0.0023 18.1 0.0 2.0 1 0 0 1 1 1 1 UBX domain Utp11 PF03998.13 CRG85442.1 - 0.057 13.3 21.8 0.081 12.8 21.8 1.2 1 0 0 1 1 1 0 Utp11 protein CDC45 PF02724.14 CRG85442.1 - 0.072 11.4 12.3 0.087 11.1 12.3 1.2 1 0 0 1 1 1 0 CDC45-like protein GATA PF00320.27 CRG85442.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 GATA zinc finger Exonuc_VII_L PF02601.15 CRG85442.1 - 0.34 10.5 8.3 0.4 10.2 8.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C2H2_2 PF12756.7 CRG85442.1 - 0.47 10.8 3.2 0.24 11.7 0.9 1.7 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) ArfGap PF01412.18 CRG85442.1 - 0.61 10.2 9.1 0.035 14.2 2.8 2.1 2 1 1 3 3 3 0 Putative GTPase activating protein for Arf DUF4551 PF15087.6 CRG85442.1 - 2.8 6.7 11.9 3.5 6.4 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC27 PF09507.10 CRG85442.1 - 6.8 6.0 28.3 8.5 5.6 28.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 V_ATPase_I PF01496.19 CRG85442.1 - 7.5 4.3 7.4 7.8 4.3 7.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 CRG85442.1 - 7.8 5.2 9.2 10 4.8 9.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 CRG85442.1 - 9 3.3 10.0 9.9 3.1 10.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Motile_Sperm PF00635.26 CRG85443.1 - 3.2e-25 88.1 0.0 8.9e-25 86.7 0.0 1.7 1 1 0 1 1 1 1 MSP (Major sperm protein) domain DotU PF09850.9 CRG85443.1 - 0.0023 17.7 0.2 0.0034 17.1 0.2 1.2 1 0 0 1 1 1 1 Type VI secretion system protein DotU FixG_C PF11614.8 CRG85443.1 - 0.017 15.4 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase Phage_lysis PF03245.13 CRG85443.1 - 0.028 14.5 0.9 0.048 13.8 0.9 1.4 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein DUF756 PF05506.12 CRG85443.1 - 0.085 13.8 0.0 0.17 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF756) ATG16 PF08614.11 CRG85443.1 - 2.4 8.3 7.1 3.9 7.7 7.1 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GET2 PF08690.10 CRG85443.1 - 7.7 6.1 8.2 12 5.5 8.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 FA_desaturase PF00487.24 CRG85444.1 - 1.9e-28 100.0 4.3 2.5e-28 99.6 4.3 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 CRG85444.1 - 4.4e-18 64.5 0.1 7.3e-18 63.8 0.1 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Peptidase_M24 PF00557.24 CRG85445.1 - 7.1e-43 146.7 0.1 9.8e-43 146.3 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Pectinesterase PF01095.19 CRG85445.1 - 0.023 13.4 0.1 0.036 12.8 0.1 1.2 1 0 0 1 1 1 0 Pectinesterase YL1 PF05764.13 CRG85445.1 - 0.046 13.8 8.3 0.073 13.2 8.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Med3 PF11593.8 CRG85445.1 - 0.11 11.7 2.2 0.18 11.0 2.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal PGA2 PF07543.12 CRG85445.1 - 0.13 12.2 6.9 0.32 11.0 6.9 1.6 1 0 0 1 1 1 0 Protein trafficking PGA2 Casc1 PF12366.8 CRG85445.1 - 2.5 7.6 5.5 5.5 6.4 3.3 2.1 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 DnaJ PF00226.31 CRG85446.1 - 9.4e-23 80.1 0.7 1.6e-22 79.4 0.7 1.4 1 0 0 1 1 1 1 DnaJ domain Porin_3 PF01459.22 CRG85447.1 - 2.9e-76 256.5 2.7 3.3e-76 256.3 2.7 1.0 1 0 0 1 1 1 1 Eukaryotic porin Asn_synthase PF00733.21 CRG85448.1 - 1e-90 305.0 0.2 1e-87 295.1 0.2 2.2 1 1 0 1 1 1 1 Asparagine synthase UQ_con PF00179.26 CRG85448.1 - 1.8e-44 150.8 0.0 3.4e-44 149.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme GATase_7 PF13537.6 CRG85448.1 - 3.1e-35 120.8 0.0 5.4e-35 120.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 CRG85448.1 - 3.4e-25 88.8 0.0 6.2e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain G-patch PF01585.23 CRG85448.1 - 2.4e-10 40.1 2.2 5.2e-10 39.1 2.2 1.5 1 0 0 1 1 1 1 G-patch domain DUF3700 PF12481.8 CRG85448.1 - 5.9e-07 29.2 0.0 1.2e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein RRM_1 PF00076.22 CRG85448.1 - 0.00098 18.9 0.1 0.0069 16.2 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Prok-E2_B PF14461.6 CRG85448.1 - 0.0024 17.5 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B NAD_synthase PF02540.17 CRG85448.1 - 0.044 12.9 0.0 0.078 12.1 0.0 1.4 1 0 0 1 1 1 0 NAD synthase Aminotran_4 PF01063.19 CRG85449.1 - 2.3e-37 129.0 0.0 3e-37 128.6 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Amidohydro_2 PF04909.14 CRG85450.1 - 1e-47 163.3 0.1 1.2e-47 163.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase bZIP_1 PF00170.21 CRG85452.1 - 0.00095 19.2 8.6 0.0023 18.0 8.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CRG85452.1 - 0.011 15.9 8.3 0.019 15.0 8.3 1.4 1 0 0 1 1 1 0 Basic region leucine zipper CK_II_beta PF01214.18 CRG85453.1 - 5.3e-78 261.0 0.0 9.4e-78 260.2 0.0 1.4 1 1 0 1 1 1 1 Casein kinase II regulatory subunit DUF4637 PF15470.6 CRG85453.1 - 0.071 12.8 4.0 0.19 11.5 4.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Spt5_N PF11942.8 CRG85453.1 - 0.095 13.7 12.2 0.067 14.2 6.7 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal RRN3 PF05327.11 CRG85453.1 - 0.72 8.3 1.3 0.95 7.9 1.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 CRG85453.1 - 5.2 5.0 5.5 7.3 4.6 5.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 CRG85453.1 - 6.5 6.0 6.3 11 5.2 6.3 1.3 1 0 0 1 1 1 0 NOA36 protein Fungal_trans PF04082.18 CRG85454.1 - 1.5e-18 66.8 0.0 2.8e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85454.1 - 2.2e-08 34.0 8.3 3.8e-08 33.3 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Laminin_II PF06009.12 CRG85454.1 - 0.17 11.9 0.1 0.33 11.0 0.1 1.4 1 0 0 1 1 1 0 Laminin Domain II Pyr_redox_3 PF13738.6 CRG85456.1 - 1.7e-08 34.1 0.3 0.00068 19.0 0.1 3.3 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG85456.1 - 3e-08 33.2 0.5 0.00023 20.4 0.0 3.5 3 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CRG85456.1 - 8.4e-07 29.1 0.0 2.3e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 CRG85456.1 - 1.8e-06 26.7 0.3 5.4e-06 25.1 0.3 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like DAO PF01266.24 CRG85456.1 - 0.0029 17.3 0.2 0.7 9.4 0.1 2.5 3 0 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 CRG85456.1 - 0.018 14.3 0.2 0.13 11.5 0.0 2.1 2 0 0 2 2 2 0 Thi4 family Pyr_redox_2 PF07992.14 CRG85456.1 - 0.024 13.9 1.2 4.2 6.5 1.7 3.0 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Cupin_8 PF13621.6 CRG85457.1 - 1.6e-24 87.0 0.0 2.2e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CRG85457.1 - 0.0015 18.1 0.0 0.0032 17.0 0.0 1.5 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 CRG85457.1 - 0.031 14.7 0.0 0.15 12.5 0.0 2.2 2 1 0 2 2 2 0 JmjC domain, hydroxylase Cupin_2 PF07883.11 CRG85457.1 - 0.13 12.0 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Cupin domain DUF5580 PF17743.1 CRG85457.1 - 0.2 10.1 0.0 0.29 9.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) BRO1 PF03097.18 CRG85458.1 - 4.4e-124 414.2 0.3 8.7e-124 413.3 0.0 1.6 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CRG85458.1 - 9.5e-83 277.9 15.5 9.5e-83 277.9 15.5 1.9 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV DUF842 PF05811.13 CRG85458.1 - 2.7 7.7 5.1 5.4 6.7 0.0 2.9 4 0 0 4 4 4 0 Eukaryotic protein of unknown function (DUF842) Mito_carr PF00153.27 CRG85459.1 - 2.3e-43 146.0 5.7 9.4e-16 57.5 0.1 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Thiolase_N PF00108.23 CRG85460.1 - 3.1e-17 62.8 0.0 7.1e-17 61.6 0.0 1.6 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG85460.1 - 5.8e-12 45.3 1.1 7.6e-11 41.7 1.3 2.3 1 1 1 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 CRG85460.1 - 7.7e-07 28.9 1.4 1.6e-05 24.7 0.1 2.8 2 1 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 CRG85460.1 - 0.0035 16.9 0.1 0.0089 15.6 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SpoVAD PF07451.11 CRG85460.1 - 0.0089 14.8 0.1 0.021 13.6 0.1 1.5 1 0 0 1 1 1 1 Stage V sporulation protein AD (SpoVAD) Peptidase_S49 PF01343.18 CRG85460.1 - 0.083 12.8 0.1 0.39 10.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase family S49 PRP38_assoc PF12871.7 CRG85465.1 - 0.97 10.1 5.3 2.6 8.7 5.3 1.8 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term FTR_C PF02741.15 CRG85465.1 - 1.2 9.1 6.5 6.3 6.8 6.6 1.8 1 1 1 2 2 2 0 FTR, proximal lobe SAP130_C PF16014.5 CRG85465.1 - 7.8 5.5 14.8 9.7 5.2 14.8 1.0 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus PPTA PF01239.22 CRG85466.1 - 0.00024 20.7 2.3 0.69 9.7 0.2 3.6 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat CHD5 PF04420.14 CRG85467.1 - 1.4e-58 197.2 0.3 1.8e-58 196.9 0.3 1.1 1 0 0 1 1 1 1 CHD5-like protein Raftlin PF15250.6 CRG85467.1 - 0.022 13.5 0.0 0.029 13.1 0.0 1.1 1 0 0 1 1 1 0 Raftlin CcmD PF04995.14 CRG85467.1 - 0.097 12.8 0.1 0.097 12.8 0.1 2.3 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) zf-MYND PF01753.18 CRG85468.1 - 1.4e-10 41.0 16.1 3.1e-10 40.0 16.1 1.6 1 0 0 1 1 1 1 MYND finger BUD22 PF09073.10 CRG85468.1 - 0.00014 21.3 8.6 0.00019 21.0 8.6 1.1 1 0 0 1 1 1 1 BUD22 Ku_C PF03730.14 CRG85468.1 - 0.11 13.2 0.1 0.11 13.2 0.1 2.0 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm Ecl1 PF12855.7 CRG85468.1 - 0.11 13.7 33.7 0.46 11.6 33.7 2.0 1 1 0 1 1 1 0 ECL1/2/3 zinc binding proteins MSP1_C PF07462.11 CRG85468.1 - 2.1 6.9 5.7 3.1 6.4 5.7 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus RRM_1 PF00076.22 CRG85469.1 - 2e-14 53.1 0.7 5.8e-14 51.7 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG85469.1 - 0.03 14.3 0.2 0.14 12.2 0.1 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 CRG85469.1 - 0.035 13.7 0.0 0.071 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SMN PF06003.12 CRG85470.1 - 2e-09 37.1 0.5 2.5e-05 23.7 0.1 2.1 2 0 0 2 2 2 2 Survival motor neuron protein (SMN) AHSP PF09236.10 CRG85470.1 - 0.75 10.3 4.4 2.4 8.7 1.8 2.1 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein Neurensin PF14927.6 CRG85471.1 - 0.029 14.1 0.1 0.054 13.2 0.1 1.5 1 0 0 1 1 1 0 Neurensin TRAM_LAG1_CLN8 PF03798.16 CRG85473.1 - 7.1e-42 143.4 22.4 7.7e-41 140.0 20.6 2.0 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.11 CRG85473.1 - 1.7e-18 66.0 0.2 1.7e-18 66.0 0.2 2.4 3 0 0 3 3 3 1 TRAM1-like protein DUF957 PF06117.11 CRG85474.1 - 0.15 11.7 1.7 0.8 9.3 0.2 2.3 2 0 0 2 2 2 0 Enterobacterial protein of unknown function (DUF957) Fungal_trans_2 PF11951.8 CRG85476.1 - 4.9e-13 48.6 0.1 1.6e-12 47.0 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain HNH_2 PF13391.6 CRG85476.1 - 4.7e-09 36.2 0.0 1e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease DUF1992 PF09350.10 CRG85476.1 - 0.12 12.5 0.1 0.3 11.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1992) Rad10 PF03834.14 CRG85478.1 - 4.1e-47 158.9 0.1 6.2e-47 158.3 0.1 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 CRG85478.1 - 5.2e-05 23.8 0.0 0.00013 22.5 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 CRG85478.1 - 0.0032 17.3 0.0 0.0072 16.1 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif ssDNA_DBD PF18333.1 CRG85478.1 - 0.028 14.5 0.2 0.061 13.4 0.2 1.5 1 0 0 1 1 1 0 Non-canonical single-stranded DNA-binding domain HHH_2 PF12826.7 CRG85478.1 - 0.057 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif T4SS-DNA_transf PF02534.14 CRG85478.1 - 0.083 11.7 0.0 8.5 5.0 0.1 2.1 1 1 1 2 2 2 0 Type IV secretory system Conjugative DNA transfer RRM_1 PF00076.22 CRG85479.1 - 5.9e-60 199.0 0.1 7.4e-19 67.3 0.0 5.4 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 CRG85479.1 - 1.2e-07 32.2 0.5 15 5.8 0.0 7.0 5 3 3 8 8 8 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 CRG85479.1 - 0.00013 21.5 0.0 0.094 12.3 0.0 2.5 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 CRG85479.1 - 0.0037 17.1 0.0 1.7 8.4 0.0 3.2 2 1 1 3 3 3 1 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 CRG85479.1 - 0.004 17.2 0.1 16 5.7 0.0 3.7 3 1 0 3 3 3 0 RNA recognition motif DbpA PF03880.15 CRG85479.1 - 0.0046 16.9 0.3 0.81 9.7 0.0 2.6 2 0 0 2 2 2 1 DbpA RNA binding domain RRM_occluded PF16842.5 CRG85479.1 - 0.0069 16.2 0.1 0.25 11.2 0.0 2.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CRG85479.1 - 0.018 15.0 0.0 38 4.4 0.0 3.4 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DUF1491 PF07372.12 CRG85479.1 - 0.051 13.9 0.5 0.051 13.9 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1491) SET_assoc PF11767.8 CRG85479.1 - 0.073 12.7 0.0 3.8 7.2 0.0 3.0 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Limkain-b1 PF11608.8 CRG85479.1 - 0.087 12.9 2.0 0.73 10.0 0.0 3.5 4 1 0 4 4 4 0 Limkain b1 RRN3 PF05327.11 CRG85479.1 - 0.7 8.4 11.5 1.7 7.1 11.5 1.7 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cyt-b5 PF00173.28 CRG85480.1 - 9.8e-09 35.2 0.0 1.1e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Fungal_trans PF04082.18 CRG85483.1 - 4.2e-20 71.9 0.0 8.5e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85483.1 - 6e-06 26.3 16.8 1.2e-05 25.3 16.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHquinase_I PF01487.15 CRG85484.1 - 3.1e-44 151.9 0.0 8.2e-44 150.5 0.0 1.7 2 0 0 2 2 2 1 Type I 3-dehydroquinase DENN PF02141.21 CRG85486.1 - 3.1e-56 190.3 0.1 6.3e-56 189.3 0.1 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 CRG85486.1 - 8.9e-14 52.0 0.0 2.4e-13 50.6 0.0 1.8 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 CRG85486.1 - 1.4e-13 50.6 0.1 4.1e-13 49.1 0.1 1.9 1 0 0 1 1 1 1 dDENN domain C1_2 PF03107.16 CRG85486.1 - 0.00018 21.7 3.5 0.00037 20.7 3.5 1.5 1 0 0 1 1 1 1 C1 domain PHD PF00628.29 CRG85486.1 - 0.082 12.8 8.1 0.072 13.0 6.0 1.9 1 1 1 2 2 2 0 PHD-finger C1_1 PF00130.22 CRG85486.1 - 1.4 8.9 8.3 2.8 7.9 8.3 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF974 PF06159.13 CRG85487.1 - 2.1e-79 266.8 0.0 2.6e-79 266.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF974) zf-RING_2 PF13639.6 CRG85488.1 - 2.9e-07 30.7 5.3 2.9e-07 30.7 5.3 1.9 2 1 0 2 2 2 1 Ring finger domain SWIM PF04434.17 CRG85488.1 - 2.3e-05 23.9 0.3 4.9e-05 22.9 0.3 1.5 1 0 0 1 1 1 1 SWIM zinc finger Prok-RING_1 PF14446.6 CRG85488.1 - 0.00058 19.7 1.8 0.00058 19.7 1.8 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 CRG85488.1 - 0.00064 19.5 6.9 0.0013 18.4 6.9 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 CRG85488.1 - 0.01 16.0 6.9 0.01 16.0 6.9 2.1 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING_UBOX PF13445.6 CRG85488.1 - 0.059 13.4 5.4 0.17 11.9 5.4 1.8 1 0 0 1 1 1 0 RING-type zinc-finger UBA2_C PF16195.5 CRG85488.1 - 0.094 13.4 0.6 0.094 13.4 0.6 1.6 2 0 0 2 2 1 0 SUMO-activating enzyme subunit 2 C-terminus RINGv PF12906.7 CRG85488.1 - 0.22 11.7 8.4 0.49 10.6 8.4 1.6 1 0 0 1 1 1 0 RING-variant domain C1_1 PF00130.22 CRG85488.1 - 1.6 8.7 8.9 0.38 10.7 3.6 2.3 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SCRL PF06876.12 CRG85488.1 - 2.8 8.2 9.3 0.34 11.1 2.3 2.3 2 0 0 2 2 2 0 Plant self-incompatibility response (SCRL) protein zf-C3HC4_3 PF13920.6 CRG85488.1 - 6.6 6.7 7.6 1.2 9.1 3.9 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CENP-N PF05238.13 CRG85489.1 - 3.1e-128 428.6 0.0 3.5e-128 428.4 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like CDC45 PF02724.14 CRG85489.1 - 1.1 7.4 5.1 1.8 6.7 5.1 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4484 PF14831.6 CRG85489.1 - 1.9 8.4 5.7 0.29 11.2 1.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) bZIP_2 PF07716.15 CRG85490.1 - 7.5e-11 41.9 16.5 7.5e-11 41.9 16.5 1.8 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 CRG85490.1 - 0.018 15.1 13.3 0.038 14.1 13.3 1.6 1 0 0 1 1 1 0 bZIP transcription factor DDRGK PF09756.9 CRG85490.1 - 1.5 8.4 20.1 0.24 11.0 16.3 1.5 2 0 0 2 2 2 0 DDRGK domain HATPase_c_3 PF13589.6 CRG85492.1 - 9.4e-20 70.8 0.0 1.9e-19 69.8 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 CRG85492.1 - 9.2e-09 35.2 0.0 3e-07 30.3 0.0 2.5 2 0 0 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 CRG85492.1 - 4.4e-06 27.2 0.0 1e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RasGEF PF00617.19 CRG85493.1 - 2.4e-50 171.2 0.1 5.5e-50 170.0 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CRG85493.1 - 1.2e-13 51.2 0.0 4.7e-13 49.3 0.0 2.1 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 CRG85493.1 - 2.7e-06 27.2 0.0 5.6e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG85493.1 - 2.7e-05 23.7 0.0 6.2e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CRG85493.1 - 0.0079 15.9 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain CHASE3 PF05227.13 CRG85493.1 - 0.058 13.3 1.0 44 4.0 0.0 3.4 3 0 0 3 3 3 0 CHASE3 domain Med5 PF08689.10 CRG85494.1 - 1.5e-161 539.6 0.0 6.1e-160 534.3 0.0 2.4 1 1 0 1 1 1 1 Mediator complex subunit Med5 DUF3827 PF12877.7 CRG85496.1 - 0.28 9.5 4.1 0.33 9.3 4.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Med12-LCEWAV PF12145.8 CRG85496.1 - 0.28 10.0 1.1 0.84 8.4 0.0 1.8 1 1 1 2 2 2 0 Eukaryotic Mediator 12 subunit domain Ilar_coat PF01787.16 CRG85496.1 - 0.3 10.9 3.1 0.51 10.1 3.1 1.3 1 0 0 1 1 1 0 Ilarvirus coat protein SURF2 PF05477.11 CRG85496.1 - 0.58 9.8 5.0 0.73 9.5 5.0 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) zf-GRF PF06839.12 CRG85498.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 GRF zinc finger Aldo_ket_red PF00248.21 CRG85499.1 - 9.3e-38 130.1 0.0 4e-29 101.8 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family ELFV_dehydrog PF00208.21 CRG85500.1 - 8.1e-81 271.3 5.4 1e-80 271.0 5.4 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 CRG85500.1 - 1.6e-51 173.5 0.0 3.1e-51 172.6 0.0 1.5 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Qn_am_d_aIV PF09100.10 CRG85500.1 - 0.15 11.9 1.1 0.26 11.1 0.2 1.9 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain IV MFS_1 PF07690.16 CRG85501.1 - 4.3e-11 42.3 34.6 4.3e-11 42.3 34.6 3.5 2 2 0 2 2 2 1 Major Facilitator Superfamily DPBB_1 PF03330.18 CRG85504.1 - 2.8e-07 30.7 0.2 6.8e-07 29.5 0.2 1.7 1 1 0 1 1 1 1 Lytic transglycolase FAP PF07174.11 CRG85504.1 - 4.3 6.7 35.9 6.5 6.1 35.9 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Ribonuc_red_lgC PF02867.15 CRG85505.1 - 1.8e-187 624.0 0.0 2.7e-187 623.5 0.0 1.2 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 CRG85505.1 - 2.4e-25 88.4 0.0 6.5e-25 87.0 0.0 1.8 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 CRG85505.1 - 3.8e-17 62.6 0.0 2.1e-16 60.3 0.0 2.4 2 0 0 2 2 2 1 ATP cone domain PRK PF00485.18 CRG85505.1 - 0.0025 17.6 0.0 0.0074 16.0 0.0 1.8 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CRG85505.1 - 0.057 14.0 0.0 0.52 10.9 0.0 2.5 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 CRG85505.1 - 0.063 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF5071 PF16804.5 CRG85505.1 - 0.11 12.8 0.0 0.37 11.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5071) AAA_33 PF13671.6 CRG85505.1 - 0.16 12.1 0.5 14 5.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain Mur_ligase_M PF08245.12 CRG85507.1 - 3e-08 33.9 0.1 7.3e-08 32.6 0.2 1.5 1 1 0 1 1 1 1 Mur ligase middle domain Pkinase PF00069.25 CRG85508.1 - 1e-72 244.7 0.0 3.1e-72 243.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85508.1 - 6e-51 173.2 0.0 3.6e-50 170.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG85508.1 - 0.0017 17.2 0.0 0.0032 16.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase HEAT PF02985.22 CRG85508.1 - 0.014 15.6 1.4 27 5.4 0.0 4.6 3 0 0 3 3 3 0 HEAT repeat Kinase-like PF14531.6 CRG85508.1 - 0.022 14.1 0.0 0.26 10.6 0.0 2.3 2 0 0 2 2 2 0 Kinase-like GerD PF17898.1 CRG85508.1 - 0.037 14.0 0.9 0.089 12.7 0.9 1.7 1 0 0 1 1 1 0 Spore germination GerD central core domain DUF383 PF04063.14 CRG85508.1 - 0.32 10.6 2.3 0.57 9.8 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF383) ABC1 PF03109.16 CRG85509.1 - 3.5e-33 114.3 0.0 6.1e-33 113.5 0.0 1.4 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 CRG85509.1 - 0.067 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Mito_carr PF00153.27 CRG85511.1 - 5.4e-64 212.2 3.1 3.9e-23 81.2 0.2 3.4 2 2 1 3 3 3 3 Mitochondrial carrier protein UCR_14kD PF02271.16 CRG85512.1 - 9e-44 147.5 0.5 1e-43 147.3 0.5 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit HhH-GPD PF00730.25 CRG85513.1 - 4.1e-14 52.9 0.0 7.1e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Recep_L_domain PF01030.24 CRG85514.1 - 2.1e-05 24.6 2.4 0.044 13.9 0.7 4.1 1 1 1 3 3 3 2 Receptor L domain LRR_5 PF13306.6 CRG85514.1 - 2.9e-05 24.0 0.9 0.0017 18.3 0.9 2.6 1 1 1 2 2 2 2 BspA type Leucine rich repeat region (6 copies) Ecm33 PF12454.8 CRG85514.1 - 9e-05 22.5 2.6 9e-05 22.5 2.6 3.2 2 1 1 3 3 3 2 GPI-anchored cell wall organization protein Filament PF00038.21 CRG85515.1 - 0.0015 18.2 0.5 0.0015 18.2 0.5 1.4 2 0 0 2 2 2 1 Intermediate filament protein DivIC PF04977.15 CRG85515.1 - 0.0068 16.1 2.6 0.015 15.1 2.6 1.5 1 0 0 1 1 1 1 Septum formation initiator bZIP_1 PF00170.21 CRG85515.1 - 0.017 15.2 0.8 0.048 13.8 0.8 1.7 1 0 0 1 1 1 0 bZIP transcription factor Bap31_Bap29_C PF18035.1 CRG85515.1 - 0.02 14.9 3.1 0.034 14.2 1.9 2.0 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Macoilin PF09726.9 CRG85515.1 - 0.082 11.5 2.2 0.1 11.1 2.2 1.1 1 0 0 1 1 1 0 Macoilin family DUF948 PF06103.11 CRG85515.1 - 0.22 11.8 0.1 0.41 10.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) YabA PF06156.13 CRG85515.1 - 0.25 12.0 3.1 0.65 10.7 0.2 2.2 2 0 0 2 2 2 0 Initiation control protein YabA bZIP_Maf PF03131.17 CRG85515.1 - 6.1 7.4 11.4 1.2 9.7 3.8 2.4 2 0 0 2 2 2 0 bZIP Maf transcription factor Anp1 PF03452.14 CRG85516.1 - 2.3e-106 355.0 0.0 3.4e-106 354.5 0.0 1.2 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 CRG85516.1 - 0.0011 18.8 0.4 0.28 11.0 0.1 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 YCII PF03795.14 CRG85517.1 - 6.3e-11 42.5 0.0 7.6e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain DUF4288 PF14119.6 CRG85517.1 - 0.089 13.2 0.0 0.18 12.2 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4288) CAP59_mtransfer PF11735.8 CRG85518.1 - 9.6e-82 274.3 0.0 1.3e-81 273.8 0.0 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Glyco_transf_8 PF01501.20 CRG85518.1 - 0.03 13.9 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 8 Pkinase PF00069.25 CRG85519.1 - 2.4e-17 63.2 0.0 5.9e-17 61.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85519.1 - 6.2e-10 38.8 0.0 5.4e-09 35.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Peptidase_M49 PF03571.15 CRG85520.1 - 2.9e-242 805.0 0.0 3.5e-242 804.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M49 Sugar_tr PF00083.24 CRG85521.1 - 4e-99 332.5 17.6 5e-99 332.2 17.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG85521.1 - 4.2e-30 104.9 26.5 2.4e-20 72.8 5.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Tannase PF07519.11 CRG85522.1 - 1.3e-93 314.4 0.3 1.7e-93 314.1 0.3 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CRG85522.1 - 0.02 14.4 0.1 0.79 9.1 0.1 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family BAAT_C PF08840.11 CRG85522.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal AtuA PF07287.11 CRG85523.1 - 2.1e-131 437.8 0.2 2.5e-131 437.6 0.2 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA PUCC PF03209.15 CRG85523.1 - 0.38 9.7 0.8 0.56 9.1 0.8 1.1 1 0 0 1 1 1 0 PUCC protein SNF5 PF04855.12 CRG85526.1 - 2.8e-86 289.2 0.0 3.5e-86 288.9 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 WD40 PF00400.32 CRG85528.1 - 4e-25 87.6 23.0 4.7e-06 27.2 0.4 6.9 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85528.1 - 5.9e-11 42.5 7.9 0.00095 19.4 0.2 4.8 2 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 CRG85528.1 - 5.2e-05 23.3 9.0 0.022 14.7 0.3 2.4 1 1 1 2 2 2 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 CRG85528.1 - 0.0061 15.6 1.1 0.85 8.5 0.0 3.9 2 2 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein F-box PF00646.33 CRG85529.1 - 1.8e-05 24.5 0.6 5.5e-05 22.9 0.2 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CRG85529.1 - 2.8e-05 23.9 0.3 6.8e-05 22.7 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 CRG85529.1 - 0.018 14.9 0.0 0.034 14.0 0.0 1.5 1 0 0 1 1 1 0 F-box Sugar_tr PF00083.24 CRG85531.1 - 1.1e-110 370.6 19.3 1.4e-110 370.3 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG85531.1 - 3.1e-28 98.7 62.4 1.2e-26 93.4 31.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG85531.1 - 6.9e-05 21.5 5.8 6.9e-05 21.5 5.8 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ABC_tran PF00005.27 CRG85532.1 - 4.1e-47 160.1 0.3 1.4e-22 80.7 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CRG85532.1 - 7.6e-21 73.9 5.6 7.6e-21 73.9 5.6 3.1 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 CRG85532.1 - 3.9e-14 53.2 13.6 0.002 18.0 0.0 4.9 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG85532.1 - 1.5e-11 44.1 0.2 0.0063 16.0 0.1 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG85532.1 - 6.4e-07 30.1 10.0 0.029 14.9 0.0 4.6 5 0 0 5 5 4 2 AAA domain MMR_HSR1 PF01926.23 CRG85532.1 - 5.5e-06 26.4 0.0 0.046 13.8 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 CRG85532.1 - 6.2e-06 26.5 0.0 0.048 13.9 0.0 3.0 3 1 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 CRG85532.1 - 8.3e-06 25.8 0.1 0.098 12.6 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CRG85532.1 - 1.4e-05 24.8 0.1 0.13 12.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 CRG85532.1 - 1.4e-05 25.5 0.3 0.1 13.0 0.1 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA_15 PF13175.6 CRG85532.1 - 1.6e-05 24.8 10.5 0.22 11.2 0.0 4.9 4 1 0 4 4 4 2 AAA ATPase domain AAA_30 PF13604.6 CRG85532.1 - 1.9e-05 24.5 0.0 0.0051 16.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CRG85532.1 - 4e-05 24.2 3.0 0.34 11.4 0.0 3.6 5 0 0 5 5 3 2 AAA domain AAA_24 PF13479.6 CRG85532.1 - 0.00011 22.0 1.1 0.36 10.5 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA_33 PF13671.6 CRG85532.1 - 0.00029 21.0 3.7 0.36 11.0 0.0 3.0 3 0 0 3 3 2 2 AAA domain AAA PF00004.29 CRG85532.1 - 0.00088 19.7 0.0 0.76 10.2 0.0 2.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CRG85532.1 - 0.00097 19.4 2.8 0.27 11.5 0.0 3.0 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 CRG85532.1 - 0.0013 17.7 2.0 1.1 8.2 0.1 2.9 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CRG85532.1 - 0.0016 18.4 0.6 0.85 9.5 0.0 2.9 3 0 0 3 3 3 1 NACHT domain AAA_27 PF13514.6 CRG85532.1 - 0.0021 17.7 0.1 3.5 7.1 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 CRG85532.1 - 0.0021 18.1 0.0 3.6 7.6 0.0 3.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CRG85532.1 - 0.0042 17.5 0.0 2.3 8.6 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Dynamin_N PF00350.23 CRG85532.1 - 0.0055 16.8 4.8 6.7 6.7 2.0 3.5 2 1 0 2 2 2 0 Dynamin family MobB PF03205.14 CRG85532.1 - 0.0076 16.1 0.1 0.45 10.4 0.0 3.0 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.19 CRG85532.1 - 0.0095 15.5 0.5 0.98 9.0 0.3 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 CRG85532.1 - 0.015 15.2 0.0 1.5 8.7 0.0 2.8 2 0 0 2 2 2 0 NTPase Zeta_toxin PF06414.12 CRG85532.1 - 0.016 14.5 1.2 2.9 7.1 0.1 2.9 3 0 0 3 3 3 0 Zeta toxin Rad17 PF03215.15 CRG85532.1 - 0.028 14.3 0.1 3.8 7.4 0.0 3.1 3 0 0 3 3 3 0 Rad17 P-loop domain Roc PF08477.13 CRG85532.1 - 0.038 14.2 0.1 7.2 6.8 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2813 PF11398.8 CRG85532.1 - 0.052 12.8 1.7 0.14 11.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2813) TsaE PF02367.17 CRG85532.1 - 0.056 13.4 0.0 7.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 CRG85532.1 - 0.068 12.4 0.0 12 5.0 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_7 PF12775.7 CRG85532.1 - 0.07 12.6 0.0 6.7 6.2 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 CRG85532.1 - 0.072 13.1 0.3 8.4 6.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Arf PF00025.21 CRG85532.1 - 0.13 11.7 0.0 2.7 7.4 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF87 PF01935.17 CRG85532.1 - 0.68 10.0 12.2 2.6 8.1 0.0 4.3 5 0 0 5 5 4 0 Helicase HerA, central domain AAA_17 PF13207.6 CRG85532.1 - 1.8 9.0 5.2 22 5.5 0.2 3.6 4 0 0 4 4 3 0 AAA domain MFS_1 PF07690.16 CRG85534.1 - 8e-41 140.1 33.8 8e-41 140.1 33.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG85534.1 - 1.6e-10 40.4 11.2 1.6e-10 40.4 11.2 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter Cytochrom_B561 PF03188.16 CRG85534.1 - 8.8 6.5 11.1 2.7 8.1 0.1 3.0 3 0 0 3 3 3 0 Eukaryotic cytochrome b561 DUF1279 PF06916.13 CRG85536.1 - 2.2e-23 82.6 0.0 3.9e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) APH PF01636.23 CRG85537.1 - 2.6e-19 70.1 0.7 2e-18 67.2 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG85537.1 - 0.00065 19.4 0.0 0.0012 18.5 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 CRG85537.1 - 0.073 12.7 0.1 4.3 6.9 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.25 CRG85537.1 - 0.13 11.6 0.0 0.67 9.3 0.0 1.9 1 1 1 2 2 2 0 Protein kinase domain DUF1679 PF07914.11 CRG85537.1 - 0.2 10.5 0.2 0.55 9.0 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1679) Ribosomal_L3 PF00297.22 CRG85538.1 - 1.3e-18 67.2 5.7 1.4e-15 57.2 1.8 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Coa1 PF08695.10 CRG85539.1 - 5.4e-41 139.0 0.0 6.7e-41 138.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 VIT1 PF01988.19 CRG85540.1 - 0.097 12.5 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 VIT family JmjC PF02373.22 CRG85541.1 - 1.3e-08 35.2 0.6 1.5e-07 31.8 0.6 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase zf-4CXXC_R1 PF10497.9 CRG85541.1 - 1.3e-06 28.6 9.6 1.3e-06 28.6 9.6 2.7 2 0 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Cupin_2 PF07883.11 CRG85541.1 - 0.0075 16.0 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Cupin domain UbiA PF01040.18 CRG85543.1 - 2.2e-44 151.6 13.6 2.9e-44 151.3 13.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family PAN_1 PF00024.26 CRG85544.1 - 1.6e-13 50.4 8.8 0.00048 20.0 0.0 3.5 3 0 0 3 3 3 3 PAN domain MSA-2c PF12238.8 CRG85544.1 - 0.02 14.9 7.6 0.032 14.2 7.6 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c Mucin PF01456.17 CRG85544.1 - 1.4 8.9 13.2 0.092 12.7 7.7 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein MANEC PF07502.14 CRG85544.1 - 2.9 8.2 9.0 0.94 9.8 0.8 3.3 3 0 0 3 3 3 0 MANEC domain Glutaredoxin PF00462.24 CRG85545.1 - 5.3e-16 58.6 0.0 8.5e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin CTP_transf_like PF01467.26 CRG85547.1 - 6.8e-25 87.9 0.0 5.8e-22 78.4 0.0 3.0 3 0 0 3 3 3 2 Cytidylyltransferase-like DeoRC PF00455.22 CRG85547.1 - 0.15 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 DeoR C terminal sensor domain PRELI PF04707.14 CRG85549.1 - 9.1e-44 149.0 0.1 1.1e-43 148.8 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family AhpC-TSA PF00578.21 CRG85550.1 - 2.3e-18 66.3 0.0 1.2e-12 47.9 0.0 2.3 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 CRG85550.1 - 6e-11 42.2 0.0 4.9e-10 39.3 0.0 2.0 1 1 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 CRG85550.1 - 0.0015 18.6 0.0 0.0038 17.3 0.0 1.7 2 0 0 2 2 2 1 AhpC/TSA antioxidant enzyme Ribosomal_60s PF00428.19 CRG85550.1 - 7.9 7.1 16.7 3.9 8.1 0.4 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF1761 PF08570.10 CRG85552.1 - 2.1e-27 95.9 3.7 2.7e-27 95.5 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Methyltransf_16 PF10294.9 CRG85553.1 - 1.9e-44 151.5 0.0 2.4e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CRG85553.1 - 0.0039 16.8 0.0 0.0058 16.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CRG85553.1 - 0.0063 17.2 0.0 0.0099 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 CRG85553.1 - 0.035 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Mpp10 PF04006.12 CRG85554.1 - 6.6e-107 358.5 45.8 6.5e-106 355.2 45.8 1.9 1 1 0 1 1 1 1 Mpp10 protein adh_short_C2 PF13561.6 CRG85555.1 - 6.8e-56 189.4 0.0 8.3e-56 189.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG85555.1 - 2.6e-46 157.6 0.0 3.1e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG85555.1 - 2.4e-13 50.4 0.0 3.5e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 KR domain PALP PF00291.25 CRG85555.1 - 0.0077 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Bac_rhamnosid_C PF17390.2 CRG85555.1 - 0.015 15.1 0.2 0.94 9.3 0.0 2.4 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase C-terminal domain DUF1776 PF08643.10 CRG85555.1 - 0.057 12.8 0.0 0.096 12.0 0.0 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Oxidored_q6 PF01058.22 CRG85557.1 - 3.1e-22 78.8 0.0 4.5e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Sedlin_N PF04628.13 CRG85558.1 - 3.3e-13 49.9 0.0 4.1e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Acyl_transf_1 PF00698.21 CRG85560.1 - 3.5e-20 72.7 0.0 5.8e-12 45.7 0.0 2.1 1 1 1 2 2 2 2 Acyl transferase domain Nucleoporin_C PF03177.14 CRG85561.1 - 1.2e-167 559.3 6.7 1.6e-167 558.9 6.7 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 CRG85561.1 - 1.4e-59 202.0 0.1 3.4e-59 200.7 0.1 1.6 2 0 0 2 2 2 1 Nup133 N terminal like LIN52 PF10044.9 CRG85561.1 - 0.047 14.4 0.0 0.18 12.5 0.0 2.0 1 0 0 1 1 1 0 Retinal tissue protein HABP4_PAI-RBP1 PF04774.15 CRG85561.1 - 8.4 7.3 12.1 0.54 11.1 3.8 2.5 2 0 0 2 2 2 0 Hyaluronan / mRNA binding family DIT1_PvcA PF05141.12 CRG85564.1 - 6e-57 193.2 0.0 7.6e-57 192.9 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DUF3974 PF13120.6 CRG85564.1 - 0.043 13.9 0.1 0.077 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3974) tRNA-synt_1b PF00579.25 CRG85565.1 - 1.4e-11 44.3 0.0 1.8e-10 40.7 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) MFS_1 PF07690.16 CRG85566.1 - 1.7e-39 135.8 45.4 1.7e-39 135.8 45.4 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG85566.1 - 8e-17 60.9 13.6 8e-17 60.9 13.6 1.9 1 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG85566.1 - 2.3e-09 36.6 8.7 2.3e-09 36.6 8.7 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter Pox_A14 PF05767.12 CRG85566.1 - 0.013 15.7 0.6 0.013 15.7 0.6 2.2 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF5337 PF17272.2 CRG85566.1 - 1 9.2 6.6 13 5.7 2.9 3.4 2 0 0 2 2 2 0 Family of unknown function (DUF5337) GST_N PF02798.20 CRG85567.1 - 2.8e-17 62.8 0.0 5e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG85567.1 - 3.3e-16 59.3 0.1 5.1e-16 58.7 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG85567.1 - 5.8e-14 52.2 0.0 1.1e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG85567.1 - 6.9e-12 45.5 0.0 1.2e-11 44.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG85567.1 - 5.1e-09 36.0 0.1 1e-08 35.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG85567.1 - 7.6e-07 29.3 0.1 1.4e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CRG85567.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.6 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Zn_clus PF00172.18 CRG85568.1 - 0.37 11.0 2.7 0.21 11.7 0.5 1.7 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_1 PF00561.20 CRG85569.1 - 4.4e-20 72.4 0.0 1.1e-18 67.8 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG85569.1 - 1.7e-12 48.4 0.0 2.3e-12 48.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG85569.1 - 8.1e-11 41.6 0.0 1.6e-06 27.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF915 PF06028.11 CRG85569.1 - 0.00024 20.5 0.1 0.0013 18.1 0.0 2.2 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) RNA_Me_trans PF04252.13 CRG85569.1 - 0.12 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase FAD_binding_3 PF01494.19 CRG85571.1 - 2.6e-22 79.6 0.1 5.9e-14 52.1 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG85571.1 - 2.3e-06 27.7 0.1 2.9e-05 24.2 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG85571.1 - 0.00038 19.3 0.1 0.00074 18.3 0.1 1.5 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 CRG85571.1 - 0.00042 20.0 0.1 0.0023 17.6 0.0 1.8 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG85571.1 - 0.00049 19.4 0.1 0.0017 17.6 0.1 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG85571.1 - 0.00053 19.2 0.0 0.00092 18.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CRG85571.1 - 0.001 19.6 0.2 0.029 14.9 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HTH_12 PF08461.10 CRG85571.1 - 0.023 14.6 0.0 0.061 13.3 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain Pyr_redox_3 PF13738.6 CRG85571.1 - 0.032 13.5 0.0 0.088 12.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CRG85571.1 - 0.034 14.0 0.0 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 CRG85571.1 - 0.041 12.9 0.1 0.09 11.8 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CRG85571.1 - 0.045 13.0 0.1 0.17 11.1 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain RELT PF12606.8 CRG85571.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 Shikimate_DH PF01488.20 CRG85571.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AMP-binding PF00501.28 CRG85572.1 - 0 1065.0 0.0 3.5e-70 236.7 0.0 6.2 5 1 1 6 6 6 6 AMP-binding enzyme Condensation PF00668.20 CRG85572.1 - 1.2e-178 594.5 0.0 5.3e-40 137.5 0.0 5.4 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 CRG85572.1 - 4.3e-50 167.9 3.5 2.4e-10 40.6 0.0 6.0 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG85572.1 - 9.8e-18 64.9 0.1 0.0002 22.3 0.0 5.7 5 0 0 5 5 5 4 AMP-binding enzyme C-terminal domain DUF3328 PF11807.8 CRG85573.1 - 5.2e-34 117.9 0.1 6.4e-34 117.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Lyase_aromatic PF00221.19 CRG85574.1 - 5e-149 496.9 2.3 6.8e-149 496.5 2.3 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase DUF3328 PF11807.8 CRG85574.1 - 1.7e-19 70.5 3.0 3.2e-19 69.6 3.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) TUSC2 PF15000.6 CRG85574.1 - 0.091 13.1 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Tumour suppressor candidate 2 DUF4094 PF13334.6 CRG85575.1 - 0.12 12.8 0.1 0.31 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) DUF3328 PF11807.8 CRG85576.1 - 2.4e-26 92.9 1.4 3.1e-26 92.5 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ABC_tran PF00005.27 CRG85577.1 - 1.1e-53 181.4 0.0 6.3e-29 101.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG85577.1 - 7.4e-39 134.0 38.8 5.1e-25 88.6 14.0 2.7 3 0 0 3 3 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG85577.1 - 2.8e-08 33.5 0.0 0.05 13.0 0.0 3.9 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG85577.1 - 2.3e-07 31.5 0.0 0.00021 21.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CRG85577.1 - 4.3e-07 30.0 0.0 0.0083 16.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CRG85577.1 - 5.6e-07 29.6 0.0 0.0049 16.9 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_25 PF13481.6 CRG85577.1 - 1.7e-06 27.8 0.0 0.07 12.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CRG85577.1 - 2.8e-06 27.0 0.1 0.027 14.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CRG85577.1 - 3.4e-06 27.1 0.1 0.022 14.6 0.0 3.3 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CRG85577.1 - 3.6e-05 24.1 0.1 0.42 10.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG85577.1 - 0.00021 21.7 0.2 0.9 9.9 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 CRG85577.1 - 0.0021 18.2 0.6 0.024 14.7 0.1 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain Dynamin_N PF00350.23 CRG85577.1 - 0.0024 17.9 1.3 0.26 11.3 0.1 2.5 2 0 0 2 2 2 1 Dynamin family FtsK_SpoIIIE PF01580.18 CRG85577.1 - 0.0029 17.0 0.0 1.1 8.5 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_33 PF13671.6 CRG85577.1 - 0.004 17.3 0.0 1.5 9.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CRG85577.1 - 0.0066 16.8 0.0 3.9 7.9 0.0 2.8 3 0 0 3 3 2 1 RNA helicase IstB_IS21 PF01695.17 CRG85577.1 - 0.011 15.4 1.0 5.5 6.7 0.0 3.0 4 0 0 4 4 2 0 IstB-like ATP binding protein T2SSE PF00437.20 CRG85577.1 - 0.02 14.0 0.0 5.5 6.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.6 CRG85577.1 - 0.026 15.1 0.1 8.8 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CRG85577.1 - 0.031 14.0 0.1 4.3 7.0 0.1 2.7 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CRG85577.1 - 0.04 13.6 0.0 6.7 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF815 PF05673.13 CRG85577.1 - 0.061 12.5 0.0 4.9 6.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_15 PF13175.6 CRG85577.1 - 0.066 12.9 0.1 0.25 11.0 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 CRG85577.1 - 0.069 12.4 0.1 5.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin Adeno_IVa2 PF02456.15 CRG85577.1 - 0.072 11.9 2.6 0.088 11.6 0.0 2.4 4 0 0 4 4 4 0 Adenovirus IVa2 protein AAA_7 PF12775.7 CRG85577.1 - 0.13 11.7 0.0 4.7 6.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region MobB PF03205.14 CRG85577.1 - 0.14 12.1 0.1 17 5.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.29 CRG85577.1 - 0.15 12.5 0.0 40 4.6 0.0 2.7 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 CRG85577.1 - 0.15 11.6 1.0 5.9 6.4 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 CRG85577.1 - 0.35 10.8 1.6 27 4.6 0.1 2.9 3 0 0 3 3 3 0 NACHT domain adh_short PF00106.25 CRG85579.1 - 9.2e-37 126.4 3.4 1.3e-36 126.0 3.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85579.1 - 1.4e-28 100.1 1.0 1.8e-28 99.7 1.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85579.1 - 1.4e-05 25.1 2.7 3.5e-05 23.8 2.7 1.7 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG85579.1 - 9.4e-05 22.4 0.1 0.00016 21.7 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding FTCD_N PF07837.12 CRG85579.1 - 0.1 12.4 0.1 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Formiminotransferase domain, N-terminal subdomain DUF1776 PF08643.10 CRG85579.1 - 0.1 11.9 0.0 0.86 8.9 0.0 2.0 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) ArgoL1 PF08699.10 CRG85579.1 - 0.11 12.2 0.5 0.51 10.1 0.0 2.3 2 0 0 2 2 2 0 Argonaute linker 1 domain ALAD PF00490.21 CRG85580.1 - 3e-121 404.4 0.0 3.6e-121 404.2 0.0 1.1 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Mac_assoc PF16628.5 CRG85581.1 - 1.3e-76 257.0 10.8 1.3e-76 257.0 10.8 2.4 2 1 0 2 2 2 1 Unstructured region on maltose acetyltransferase Mac PF12464.8 CRG85581.1 - 5.6e-12 45.7 0.0 1.1e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 CRG85581.1 - 6.9e-10 38.5 3.0 5.3e-07 29.3 0.0 3.5 3 1 0 3 3 3 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 CRG85581.1 - 5e-09 35.5 4.6 0.00022 20.8 0.1 3.6 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Zn_clus PF00172.18 CRG85581.1 - 7.4e-09 35.6 9.3 1.6e-08 34.5 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CRM1_C PF08767.11 CRG85582.1 - 1.1e-137 458.5 10.4 1.1e-137 458.5 10.4 3.0 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 CRG85582.1 - 8.6e-42 142.7 12.9 4.2e-41 140.5 6.5 4.0 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 CRG85582.1 - 3.5e-34 116.3 3.7 1.9e-33 113.9 3.6 2.4 2 0 0 2 2 2 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 CRG85582.1 - 2.8e-29 101.0 0.7 2.8e-29 101.0 0.7 2.7 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 CRG85582.1 - 2.3e-20 71.8 1.8 5.4e-20 70.6 1.8 1.7 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 CRG85582.1 - 8.6e-09 35.2 0.0 3.8e-08 33.1 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Hemocyanin_M PF00372.19 CRG85582.1 - 0.05 12.8 0.1 0.13 11.4 0.1 1.6 1 0 0 1 1 1 0 Hemocyanin, copper containing domain DUF3385 PF11865.8 CRG85582.1 - 0.14 12.1 6.8 0.32 10.9 0.0 4.3 5 1 1 6 6 6 0 Domain of unknown function (DUF3385) HD_assoc PF13286.6 CRG85582.1 - 0.2 12.2 3.4 25 5.5 0.2 3.9 4 0 0 4 4 4 0 Phosphohydrolase-associated domain PPI_Ypi1 PF07491.11 CRG85584.1 - 2.5e-23 81.6 7.4 1.3e-22 79.4 7.4 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor TFIIE-A_C PF11521.8 CRG85584.1 - 0.064 13.6 2.2 1.3 9.3 0.2 2.3 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha SR-25 PF10500.9 CRG85584.1 - 0.84 9.2 19.1 0.62 9.6 16.7 1.8 1 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Shugoshin_N PF07558.11 CRG85585.1 - 1.6e-16 59.9 3.4 1.6e-16 59.9 3.4 1.9 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 CRG85585.1 - 4.2e-08 32.8 2.2 4.2e-08 32.8 2.2 3.1 3 0 0 3 3 3 1 Shugoshin C terminus bZIP_2 PF07716.15 CRG85585.1 - 0.025 14.6 1.1 0.074 13.1 0.1 2.4 2 0 0 2 2 2 0 Basic region leucine zipper CCDC85 PF10226.9 CRG85585.1 - 0.067 12.9 0.1 0.067 12.9 0.1 2.4 2 0 0 2 2 2 0 CCDC85 family HALZ PF02183.18 CRG85585.1 - 0.1 12.9 2.2 0.21 11.8 0.5 2.2 2 0 0 2 2 2 0 Homeobox associated leucine zipper DASH_Dad2 PF08654.10 CRG85586.1 - 3.5e-24 85.1 1.5 9.8e-24 83.7 1.5 1.7 1 0 0 1 1 1 1 DASH complex subunit Dad2 Ecl1 PF12855.7 CRG85586.1 - 6.9e-11 43.6 17.7 1.2e-10 42.9 17.7 1.3 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins Seryl_tRNA_N PF02403.22 CRG85586.1 - 0.13 12.5 3.1 0.16 12.3 0.9 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF2116 PF09889.9 CRG85586.1 - 0.33 11.0 3.6 0.14 12.2 0.6 1.9 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Lin-8 PF03353.15 CRG85586.1 - 1.5 8.3 4.3 2 7.9 4.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 CRG85586.1 - 4.9 5.6 11.0 0.18 10.4 5.2 1.4 2 0 0 2 2 2 0 Macoilin family DAO PF01266.24 CRG85587.1 - 1.1e-50 173.3 0.0 1.4e-50 172.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 CRG85587.1 - 1.1e-43 148.0 0.0 2.1e-43 147.2 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 CRG85587.1 - 1.3e-09 37.7 0.1 2.5e-09 36.7 0.1 1.5 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CRG85587.1 - 0.00021 20.8 0.2 0.00089 18.7 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG85587.1 - 0.00071 18.9 0.0 0.0019 17.5 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG85587.1 - 0.0016 18.6 0.1 0.0068 16.6 0.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 CRG85587.1 - 0.019 14.8 0.2 0.036 13.9 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 CRG85587.1 - 0.029 13.6 0.0 0.088 12.0 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG85587.1 - 0.036 12.8 0.6 0.086 11.5 0.3 1.7 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 CRG85587.1 - 0.054 14.1 0.1 0.14 12.8 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG85587.1 - 0.13 11.3 0.6 0.46 9.5 0.3 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A NFACT-R_1 PF05670.13 CRG85588.1 - 7.6e-33 113.4 0.1 1.4e-32 112.6 0.1 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain TBCC PF07986.12 CRG85588.1 - 0.00098 18.8 0.0 0.0045 16.7 0.0 2.0 2 0 0 2 2 2 1 Tubulin binding cofactor C GRAB PF10375.9 CRG85589.1 - 1.1e-08 34.6 0.1 2.4e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Spc7 PF08317.11 CRG85589.1 - 0.0032 16.4 26.6 0.0032 16.4 26.6 2.7 1 1 1 2 2 2 1 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 CRG85589.1 - 0.13 12.3 20.1 0.51 10.4 2.9 3.9 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus MIT PF04212.18 CRG85589.1 - 0.16 12.0 7.2 5 7.3 1.8 3.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain BST2 PF16716.5 CRG85589.1 - 0.33 11.6 39.6 0.035 14.7 5.6 5.0 2 2 1 4 4 4 0 Bone marrow stromal antigen 2 Filament PF00038.21 CRG85589.1 - 0.59 9.7 47.0 5 6.6 29.3 2.9 1 1 1 2 2 2 0 Intermediate filament protein Golgin_A5 PF09787.9 CRG85589.1 - 1.1 8.6 55.6 0.055 12.9 19.2 3.5 1 1 3 4 4 4 0 Golgin subfamily A member 5 Atg14 PF10186.9 CRG85589.1 - 1.2 8.1 45.7 0.24 10.5 20.0 3.5 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 FPP PF05911.11 CRG85589.1 - 1.8 6.6 55.2 0.68 8.0 32.4 3.2 1 1 2 3 3 3 0 Filament-like plant protein, long coiled-coil COG5 PF10392.9 CRG85589.1 - 2 8.6 18.3 0.053 13.7 5.6 2.9 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Fib_alpha PF08702.10 CRG85589.1 - 3.9 7.6 33.3 0.25 11.5 11.6 4.0 3 2 1 4 4 4 0 Fibrinogen alpha/beta chain family DUF948 PF06103.11 CRG85589.1 - 4.7 7.5 17.4 6.1 7.2 0.2 4.4 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) FUSC PF04632.12 CRG85589.1 - 5.6 5.4 21.7 3.2 6.2 9.7 2.2 2 0 0 2 2 2 0 Fusaric acid resistance protein family FliJ PF02050.16 CRG85589.1 - 6.3 7.0 42.0 2.5 8.4 5.3 4.3 1 1 3 4 4 4 0 Flagellar FliJ protein DUF4618 PF15397.6 CRG85589.1 - 7.3 5.9 40.1 0.37 10.2 14.6 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) FlaC_arch PF05377.11 CRG85589.1 - 7.7 7.0 24.0 18 5.8 1.1 5.8 3 2 3 6 6 6 0 Flagella accessory protein C (FlaC) Guanylate_kin PF00625.21 CRG85590.1 - 1.1e-56 191.4 0.0 1.3e-56 191.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 CRG85590.1 - 3.8e-06 27.4 0.2 7.9e-06 26.3 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 CRG85590.1 - 2.1e-05 25.1 0.1 5.1e-05 23.8 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CRG85590.1 - 9.4e-05 22.7 0.0 0.00023 21.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CRG85590.1 - 0.00015 21.9 0.4 0.0013 18.9 0.4 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 CRG85590.1 - 0.00085 19.3 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 CRG85590.1 - 0.0015 18.8 0.0 0.0048 17.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CRG85590.1 - 0.0022 17.6 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 CRG85590.1 - 0.0024 18.4 0.0 0.0026 18.3 0.0 1.5 1 1 0 1 1 1 1 ABC transporter DUF2075 PF09848.9 CRG85590.1 - 0.0026 17.1 0.0 0.12 11.5 0.0 2.0 1 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 CRG85590.1 - 0.003 17.9 0.0 0.0056 17.1 0.0 1.6 1 1 0 1 1 1 1 RNA helicase T2SSE PF00437.20 CRG85590.1 - 0.004 16.3 0.0 0.009 15.1 0.0 1.5 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CRG85590.1 - 0.0066 16.5 0.0 0.0091 16.1 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 CRG85590.1 - 0.0071 16.1 0.0 0.087 12.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CRG85590.1 - 0.0094 16.4 0.1 0.024 15.0 0.0 1.7 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CRG85590.1 - 0.01 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 CRG85590.1 - 0.015 15.2 0.1 0.032 14.1 0.1 1.6 1 1 0 1 1 1 0 NTPase AAA_14 PF13173.6 CRG85590.1 - 0.018 15.0 0.0 0.031 14.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CRG85590.1 - 0.021 14.6 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 CRG85590.1 - 0.031 13.9 0.0 0.31 10.6 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CRG85590.1 - 0.032 13.9 0.0 0.072 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG85590.1 - 0.037 14.0 0.2 0.11 12.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 CRG85590.1 - 0.043 13.7 0.1 0.052 13.4 0.1 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea dNK PF01712.19 CRG85590.1 - 0.069 13.0 0.1 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase Rad17 PF03215.15 CRG85590.1 - 0.082 12.8 0.0 0.12 12.3 0.0 1.4 1 1 0 1 1 1 0 Rad17 P-loop domain DUF3885 PF13021.6 CRG85590.1 - 0.17 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3885) Septin PF00735.18 CRG85591.1 - 2.4e-113 378.1 1.3 2.8e-113 377.9 1.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CRG85591.1 - 3.6e-08 33.5 0.0 8.2e-08 32.3 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 CRG85591.1 - 1e-05 24.9 0.0 1.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 CRG85591.1 - 9e-05 22.4 0.7 0.00052 20.0 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CRG85591.1 - 9.6e-05 22.0 1.3 0.022 14.3 0.1 2.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CRG85591.1 - 0.00027 21.0 0.4 0.81 9.7 0.2 2.5 1 1 1 2 2 2 2 Dynamin family AAA_7 PF12775.7 CRG85591.1 - 0.00077 19.0 0.1 0.0045 16.5 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 CRG85591.1 - 0.0046 17.4 0.0 0.0095 16.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CRG85591.1 - 0.0053 16.0 0.1 0.0096 15.1 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain ABC_tran PF00005.27 CRG85591.1 - 0.011 16.2 0.8 0.016 15.7 0.4 1.7 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 CRG85591.1 - 0.013 15.7 0.0 0.026 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 CRG85591.1 - 0.02 14.3 0.1 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Roc PF08477.13 CRG85591.1 - 0.041 14.1 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 CRG85591.1 - 0.042 13.0 0.6 0.32 10.1 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 CRG85591.1 - 0.066 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 CRG85591.1 - 0.14 11.9 0.0 0.31 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ribosomal_L32p PF01783.23 CRG85592.1 - 4.1e-14 52.6 7.7 5.4e-14 52.2 7.7 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family DZR PF12773.7 CRG85592.1 - 0.0048 16.9 0.9 0.0078 16.2 0.9 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 CRG85592.1 - 0.038 13.4 3.6 0.067 12.6 3.6 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 CRG85592.1 - 0.096 12.4 2.4 1.2 9.0 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf_C2H2_13 PF18508.1 CRG85592.1 - 0.26 10.9 2.6 0.17 11.5 0.9 1.6 1 1 1 2 2 2 0 Zinc finger domain WD40 PF00400.32 CRG85593.1 - 1.7e-24 85.6 14.7 3.2e-08 34.1 1.3 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85593.1 - 6.4e-15 55.2 3.5 0.0018 18.6 0.6 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG85593.1 - 9.5e-05 22.4 0.1 0.036 13.9 0.0 3.1 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CRG85593.1 - 0.00012 21.6 0.0 0.068 12.5 0.0 2.6 2 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 CRG85593.1 - 0.0037 16.0 0.5 0.87 8.1 0.0 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 CRG85593.1 - 0.0064 15.1 0.1 0.64 8.5 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain LRR_6 PF13516.6 CRG85593.1 - 0.051 13.6 0.1 5 7.4 0.0 2.5 2 0 0 2 2 2 0 Leucine Rich repeat Coatomer_WDAD PF04053.14 CRG85593.1 - 0.052 12.6 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 Coatomer WD associated region VID27 PF08553.10 CRG85593.1 - 0.054 12.5 0.1 0.12 11.4 0.0 1.6 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Spindle_Spc25 PF08234.12 CRG85594.1 - 2e-21 76.0 0.0 5.4e-21 74.6 0.0 1.8 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Polysacc_deac_1 PF01522.21 CRG85594.1 - 0.019 14.9 1.0 0.038 13.9 1.0 1.4 1 0 0 1 1 1 0 Polysaccharide deacetylase SIS PF01380.22 CRG85594.1 - 0.051 13.4 0.3 0.074 12.9 0.3 1.2 1 0 0 1 1 1 0 SIS domain Calpain_III PF01067.22 CRG85594.1 - 0.23 11.7 1.4 0.35 11.1 1.4 1.2 1 0 0 1 1 1 0 Calpain large subunit, domain III Rrn6 PF10214.9 CRG85595.1 - 1.9e-165 552.7 2.3 2.3e-165 552.5 2.3 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor RNA_bind PF08675.11 CRG85595.1 - 0.025 14.6 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 RNA binding domain HMA PF00403.26 CRG85596.1 - 1.5e-15 57.4 0.3 1.7e-15 57.2 0.3 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain Fer2_BFD PF04324.15 CRG85596.1 - 0.078 13.3 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 BFD-like [2Fe-2S] binding domain DUF2293 PF10056.9 CRG85597.1 - 2.7e-31 107.6 0.3 6.6e-31 106.4 0.3 1.7 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) zinc_ribbon_6 PF14599.6 CRG85598.1 - 1.9e-25 88.6 0.5 1.9e-25 88.6 0.5 2.2 2 0 0 2 2 2 1 Zinc-ribbon zf-Sec23_Sec24 PF04810.15 CRG85598.1 - 0.0041 17.1 0.3 0.02 14.9 0.0 2.3 2 1 0 2 2 2 1 Sec23/Sec24 zinc finger HypA PF01155.19 CRG85598.1 - 0.089 12.8 0.1 0.089 12.8 0.1 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ZZ PF00569.17 CRG85598.1 - 0.95 9.3 6.8 5.8 6.8 0.5 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type DZR PF12773.7 CRG85598.1 - 1 9.5 5.3 6.1 6.9 0.3 2.3 2 0 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.6 CRG85598.1 - 6.9 7.1 8.8 1.4e+02 3.0 8.8 2.7 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF3632 PF12311.8 CRG85599.1 - 7e-29 101.5 0.0 1.3e-28 100.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Tcp11 PF05794.13 CRG85600.1 - 5.6e-109 365.2 0.0 5.6e-109 365.2 0.0 2.6 3 0 0 3 3 3 1 T-complex protein 11 UPF0242 PF06785.11 CRG85600.1 - 2.2 8.4 8.5 5.3 7.1 8.5 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Amino_oxidase PF01593.24 CRG85601.1 - 2.1e-71 241.6 0.0 2.4e-71 241.4 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CRG85601.1 - 2.6e-13 50.0 0.1 6.3e-13 48.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG85601.1 - 3.9e-10 39.8 4.5 5.9e-09 36.0 4.5 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG85601.1 - 1.9e-07 30.2 1.5 0.00018 20.3 0.6 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 CRG85601.1 - 3.5e-06 26.6 0.7 5.2e-06 26.1 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG85601.1 - 4.2e-06 26.1 2.9 5.2e-06 25.8 1.6 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CRG85601.1 - 4.6e-06 27.1 1.0 3.4e-05 24.3 0.3 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG85601.1 - 7.9e-06 25.3 0.6 7.5e-05 22.1 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG85601.1 - 1.2e-05 24.8 0.0 0.021 14.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG85601.1 - 1.2e-05 24.7 1.8 2.4e-05 23.7 1.3 1.7 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CRG85601.1 - 3e-05 24.1 6.3 0.041 13.9 0.1 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 CRG85601.1 - 0.00017 21.0 0.2 0.00029 20.1 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CRG85601.1 - 0.00045 19.4 1.8 0.055 12.5 0.9 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein GIDA PF01134.22 CRG85601.1 - 0.012 14.8 0.4 0.065 12.3 0.4 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CRG85601.1 - 0.014 14.7 3.8 0.017 14.5 0.4 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 CRG85601.1 - 0.018 15.6 0.4 2.4 8.8 0.3 2.7 2 1 1 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent FMO-like PF00743.19 CRG85601.1 - 0.26 9.7 0.1 0.35 9.2 0.1 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like MCRA PF06100.11 CRG85601.1 - 0.27 10.0 0.0 0.4 9.4 0.0 1.2 1 0 0 1 1 1 0 MCRA family WD40 PF00400.32 CRG85602.1 - 1.2e-33 114.5 19.2 1e-07 32.5 0.2 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85602.1 - 4.2e-11 43.0 2.8 0.18 12.1 0.0 6.0 6 2 2 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain ADH_zinc_N PF00107.26 CRG85603.1 - 2.4e-12 47.0 0.1 5.3e-12 45.8 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG85603.1 - 3.4e-06 26.9 0.0 9.2e-06 25.5 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CRG85603.1 - 0.00052 19.5 0.3 0.00091 18.7 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Acylphosphatase PF00708.18 CRG85603.1 - 0.15 12.5 0.0 2.4 8.6 0.0 2.2 2 0 0 2 2 2 0 Acylphosphatase Fungal_trans PF04082.18 CRG85604.1 - 1.9e-15 56.7 0.1 3.3e-15 55.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85604.1 - 2.3e-07 30.8 15.7 2.3e-07 30.8 15.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran_CTD PF16326.5 CRG85604.1 - 4 7.8 4.9 2.7 8.3 0.4 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain Peptidase_S10 PF00450.22 CRG85605.1 - 7.7e-123 411.0 0.0 9.3e-123 410.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase RNA_Me_trans PF04252.13 CRG85606.1 - 1.3e-84 282.7 0.0 1.5e-84 282.6 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase bPH_5 PF10882.8 CRG85606.1 - 0.045 13.8 0.0 4 7.6 0.1 2.2 2 0 0 2 2 2 0 Bacterial PH domain Endosulfine PF04667.17 CRG85607.1 - 6.8e-29 99.8 0.0 1.4e-28 98.9 0.0 1.5 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region ICE2 PF08426.10 CRG85608.1 - 7.2e-157 522.7 9.2 8.1e-157 522.5 9.2 1.0 1 0 0 1 1 1 1 ICE2 Yae1_N PF09811.9 CRG85609.1 - 1.7e-08 34.0 4.0 2.7e-08 33.4 4.0 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal WD40 PF00400.32 CRG85610.1 - 4.2e-17 62.2 4.7 0.0038 18.0 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85610.1 - 1.5e-06 28.4 0.0 0.44 10.9 0.0 5.3 2 2 5 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CRG85610.1 - 0.00089 18.7 0.0 0.0016 17.8 0.0 1.3 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 CRG85610.1 - 0.015 14.3 0.1 0.27 10.2 0.0 2.9 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Abhydrolase_1 PF00561.20 CRG85613.1 - 4.4e-09 36.4 0.0 1.6e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG85613.1 - 1.7e-07 32.1 0.7 1.7e-07 32.1 0.7 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG85613.1 - 9e-05 21.9 0.0 0.00029 20.2 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 CRG85613.1 - 0.13 12.1 0.3 0.33 10.8 0.0 1.8 2 0 0 2 2 2 0 Serine hydrolase Prefoldin_2 PF01920.20 CRG85613.1 - 0.13 12.2 5.7 0.24 11.4 5.7 1.3 1 0 0 1 1 1 0 Prefoldin subunit DUF1043 PF06295.12 CRG85613.1 - 2 8.4 5.1 4.1 7.4 5.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Gryzun PF07919.12 CRG85614.1 - 2.1e-225 750.0 0.1 2.7e-225 749.7 0.1 1.1 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Foie-gras_1 PF11817.8 CRG85614.1 - 3.1e-96 321.9 3.3 9.1e-85 284.4 4.2 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 LptE PF04390.12 CRG85614.1 - 0.12 13.1 0.1 0.47 11.2 0.1 2.1 1 0 0 1 1 1 0 Lipopolysaccharide-assembly RXT2_N PF08595.11 CRG85615.1 - 2.6e-34 118.5 0.5 2.6e-34 118.5 0.5 2.7 2 1 0 2 2 2 1 RXT2-like, N-terminal PEMT PF04191.13 CRG85616.1 - 9.1e-34 116.0 6.7 5.8e-33 113.5 3.2 2.3 3 0 0 3 3 3 1 Phospholipid methyltransferase EPV_E5 PF08135.11 CRG85616.1 - 0.057 13.8 0.6 0.17 12.3 0.6 1.8 1 0 0 1 1 1 0 Major transforming protein E5 family DUF1223 PF06764.11 CRG85616.1 - 0.06 13.4 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) GET2 PF08690.10 CRG85617.1 - 0.037 13.7 0.0 0.054 13.2 0.0 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 PXA PF02194.15 CRG85618.1 - 2.5e-50 171.0 0.3 9.2e-50 169.1 0.3 2.0 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 CRG85618.1 - 4.5e-27 94.9 0.1 8.5e-26 90.7 0.0 3.1 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 CRG85618.1 - 4.7e-19 68.4 0.8 1.1e-18 67.2 0.8 1.7 1 0 0 1 1 1 1 PX domain RGS PF00615.19 CRG85618.1 - 1.3e-12 48.0 0.2 4.4e-12 46.3 0.2 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4589 PF15252.6 CRG85618.1 - 0.0029 17.7 0.9 0.0096 16.0 0.9 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4589) RRP36 PF06102.12 CRG85618.1 - 0.57 10.1 4.2 0.71 9.8 0.1 2.4 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 TMF_DNA_bd PF12329.8 CRG85618.1 - 0.79 9.8 5.2 5.9 7.0 0.0 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CD20 PF04103.15 CRG85618.1 - 1.5 8.9 3.2 2.6 8.1 3.2 1.3 1 0 0 1 1 1 0 CD20-like family Ribosomal_L6 PF00347.23 CRG85619.1 - 8.4e-20 71.2 2.3 1.4e-09 38.4 0.1 2.6 2 0 0 2 2 2 2 Ribosomal protein L6 Glutaredoxin PF00462.24 CRG85619.1 - 2.7e-12 46.7 0.1 1.8e-11 44.1 0.0 2.4 2 0 0 2 2 2 1 Glutaredoxin NBD_C PF17042.5 CRG85619.1 - 0.083 13.4 0.0 0.24 11.9 0.0 1.8 1 1 0 1 1 1 0 Nucleotide-binding C-terminal domain DUF3336 PF11815.8 CRG85621.1 - 4.3e-37 126.9 0.5 1.2e-33 115.7 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3336) Patatin PF01734.22 CRG85621.1 - 4.6e-16 59.6 1.4 6.1e-16 59.2 0.2 1.7 2 0 0 2 2 2 1 Patatin-like phospholipase PhoD PF09423.10 CRG85623.1 - 1.4e-06 27.6 2.3 0.00031 19.9 0.5 2.6 2 1 0 2 2 2 2 PhoD-like phosphatase Fungal_trans_2 PF11951.8 CRG85624.1 - 1.5e-31 109.6 0.2 2.1e-31 109.1 0.2 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85624.1 - 1.5e-06 28.2 8.5 3.5e-06 27.0 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_permease_2 PF13520.6 CRG85625.1 - 1.1e-44 152.9 48.8 1.5e-44 152.5 48.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG85625.1 - 1.1e-25 90.2 43.2 1.5e-25 89.8 43.2 1.0 1 0 0 1 1 1 1 Amino acid permease Rhomboid PF01694.22 CRG85626.1 - 1.2e-22 80.6 8.7 1.2e-22 80.6 8.7 1.5 2 0 0 2 2 2 1 Rhomboid family SIP PF04954.13 CRG85626.1 - 0.1 13.1 1.1 0.23 12.0 1.1 1.6 1 1 0 1 1 1 0 Siderophore-interacting protein Shugoshin_N PF07558.11 CRG85628.1 - 0.011 15.6 0.4 0.031 14.1 0.3 1.7 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 CRG85628.1 - 0.017 14.8 1.2 3.6 7.4 0.0 2.1 1 1 1 2 2 2 0 Septum formation initiator ZapB PF06005.12 CRG85628.1 - 0.022 15.2 1.3 0.065 13.7 0.5 1.9 1 1 1 2 2 2 0 Cell division protein ZapB ATG16 PF08614.11 CRG85628.1 - 0.043 14.1 0.1 0.059 13.6 0.1 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4618 PF15397.6 CRG85628.1 - 0.059 12.8 1.4 4.5 6.6 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) HEPN_RiboL-PSP PF18735.1 CRG85628.1 - 0.071 13.0 0.0 0.096 12.6 0.0 1.1 1 0 0 1 1 1 0 RiboL-PSP-HEPN MitMem_reg PF13012.6 CRG85628.1 - 0.074 13.5 0.1 0.095 13.1 0.1 1.3 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function Mob1_phocein PF03637.17 CRG85629.1 - 5.8e-51 172.9 0.0 4.6e-50 169.9 0.0 2.0 1 1 0 1 1 1 1 Mob1/phocein family Leo1 PF04004.13 CRG85630.1 - 2.7e-28 98.9 0.1 1.3e-27 96.7 0.1 2.1 1 1 0 1 1 1 1 Leo1-like protein Caf4 PF11615.8 CRG85630.1 - 0.035 14.1 0.1 0.081 12.9 0.1 1.5 1 0 0 1 1 1 0 CCR4-associated factor 4 U3_assoc_6 PF08640.11 CRG85632.1 - 2.5e-28 97.9 0.6 1.4e-27 95.6 0.1 2.2 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 CRG85632.1 - 5.9e-07 29.8 0.6 0.0055 17.4 0.2 3.2 1 1 1 2 2 2 2 Tetratricopeptide repeat NRDE-2 PF08424.10 CRG85632.1 - 0.0083 15.3 0.1 0.014 14.5 0.1 1.3 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference Frag1 PF10277.9 CRG85633.1 - 6e-40 137.1 7.2 6e-40 137.1 7.2 3.2 3 0 0 3 3 3 1 Frag1/DRAM/Sfk1 family Lactamase_B_6 PF16661.5 CRG85634.1 - 4.2e-65 218.8 0.0 8e-65 217.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 CRG85634.1 - 8.4e-49 166.0 1.5 1e-48 165.7 0.1 1.9 2 0 0 2 2 2 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 CRG85634.1 - 3.1e-15 56.4 0.1 1.2e-14 54.5 0.0 2.1 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 CRG85634.1 - 1.7e-11 43.9 0.0 3.7e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 CRG85634.1 - 0.058 12.9 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CRG85634.1 - 0.077 13.0 0.1 0.23 11.4 0.1 1.8 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily CDH-cyt PF16010.5 CRG85636.1 - 4.8e-20 72.0 3.4 7.7e-20 71.3 3.4 1.2 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase DOMON PF03351.17 CRG85636.1 - 7.9e-05 22.9 0.1 0.00014 22.1 0.1 1.4 1 0 0 1 1 1 1 DOMON domain Cytochrom_B561 PF03188.16 CRG85636.1 - 0.00023 21.3 11.8 0.00023 21.3 11.8 2.3 1 1 1 2 2 2 1 Eukaryotic cytochrome b561 MFS_1 PF07690.16 CRG85637.1 - 8.1e-39 133.5 59.2 4.1e-37 127.9 38.9 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Fzo_mitofusin PF04799.13 CRG85637.1 - 2.8 7.5 4.0 1.5 8.4 0.1 2.5 3 0 0 3 3 3 0 fzo-like conserved region Fungal_trans_2 PF11951.8 CRG85638.1 - 6.6e-69 232.6 0.0 8.2e-69 232.2 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85638.1 - 2.4e-09 37.2 10.4 3.8e-09 36.5 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 CRG85638.1 - 0.44 10.6 6.8 1.2 9.2 6.8 1.8 1 0 0 1 1 1 0 AT hook motif DUF5396 PF17374.2 CRG85638.1 - 0.54 8.1 2.6 0.74 7.6 2.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5396) DUF2434 PF10361.9 CRG85641.1 - 2e-49 168.2 0.1 2e-49 168.2 0.1 2.8 3 0 0 3 3 3 2 Protein of unknown function (DUF2434) Glyco_hydro_15 PF00723.21 CRG85642.1 - 4.3e-41 141.1 0.0 2.3e-39 135.5 0.0 2.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 Methyltransf_25 PF13649.6 CRG85643.1 - 3.9e-15 56.3 0.0 8.6e-15 55.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85643.1 - 1.2e-14 54.7 0.0 2.3e-14 53.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85643.1 - 1.8e-11 44.1 0.0 2.7e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG85643.1 - 4e-09 36.5 0.0 5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85643.1 - 1.1e-08 35.7 0.0 1.9e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 CRG85643.1 - 1.5e-06 28.0 0.0 2.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 CRG85643.1 - 3.6e-05 23.2 0.0 4.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CRG85643.1 - 8.1e-05 22.2 0.0 0.00012 21.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 CRG85643.1 - 0.029 13.7 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 CRG85643.1 - 0.077 13.0 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain AflR PF08493.10 CRG85643.1 - 0.22 11.0 0.0 0.28 10.6 0.0 1.1 1 0 0 1 1 1 0 Aflatoxin regulatory protein Sec23_trunk PF04811.15 CRG85645.1 - 5.7e-49 166.9 0.0 9.5e-49 166.2 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 CRG85645.1 - 1.4e-25 89.0 0.0 5.1e-25 87.3 0.0 2.0 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 CRG85645.1 - 5.5e-18 65.5 0.0 1e-17 64.6 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 CRG85645.1 - 5.3e-16 58.4 5.4 1.4e-15 57.0 5.4 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CRG85645.1 - 2.2e-07 30.7 0.0 5e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat DUF1678 PF07913.11 CRG85645.1 - 0.14 11.9 0.1 0.25 11.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1678) tRNA-synt_2 PF00152.20 CRG85646.1 - 4.2e-68 229.7 0.0 3.6e-67 226.7 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) AA_permease_2 PF13520.6 CRG85646.1 - 1e-58 199.2 47.5 1.3e-58 198.9 47.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG85646.1 - 1.1e-20 73.7 38.1 1.5e-20 73.3 38.1 1.1 1 0 0 1 1 1 1 Amino acid permease tRNA_anti-codon PF01336.25 CRG85646.1 - 4.5e-07 29.8 0.0 1.1e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2721 PF11026.8 CRG85646.1 - 0.47 10.3 0.0 0.47 10.3 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) Gti1_Pac2 PF09729.9 CRG85647.1 - 1.6e-45 155.5 0.4 2.4e-37 128.8 0.0 2.2 1 1 1 2 2 2 2 Gti1/Pac2 family Abhydrolase_3 PF07859.13 CRG85648.1 - 1.5e-42 145.9 0.0 2.1e-42 145.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CRG85648.1 - 0.0059 15.5 0.0 0.009 14.9 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Thioesterase PF00975.20 CRG85648.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain RRM_1 PF00076.22 CRG85650.1 - 1.1e-13 50.8 0.0 2.9e-13 49.4 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Apolipoprotein PF01442.18 CRG85650.1 - 0.0054 16.6 2.5 0.0078 16.1 1.4 1.7 2 0 0 2 2 2 1 Apolipoprotein A1/A4/E domain WXG100 PF06013.12 CRG85650.1 - 0.013 15.7 0.8 0.049 13.9 0.9 2.0 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Phage_Coat_Gp8 PF05371.12 CRG85650.1 - 0.073 12.8 2.3 9.4 6.1 1.0 2.8 2 0 0 2 2 2 0 Phage major coat protein, Gp8 TarH PF02203.15 CRG85650.1 - 0.25 11.2 6.6 0.32 10.9 0.1 2.7 3 0 0 3 3 3 0 Tar ligand binding domain homologue MOZ_SAS PF01853.18 CRG85651.1 - 2.2e-63 213.2 0.0 3.5e-63 212.5 0.0 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 CRG85651.1 - 6.7e-07 28.8 0.0 2e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 MYST family zinc finger domain IF2_N PF04760.15 CRG85651.1 - 0.093 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region Cpn60_TCP1 PF00118.24 CRG85652.1 - 7.9e-163 542.6 0.7 8.9e-163 542.4 0.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Nop PF01798.18 CRG85653.1 - 5.2e-89 297.6 0.1 5.2e-89 297.6 0.1 1.8 2 0 0 2 2 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CRG85653.1 - 8.8e-20 70.9 0.1 8.8e-20 70.9 0.1 2.4 2 0 0 2 2 1 1 NOP5NT (NUC127) domain Rrn6 PF10214.9 CRG85653.1 - 0.0045 15.6 4.5 0.0051 15.4 4.5 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor YL1 PF05764.13 CRG85653.1 - 0.13 12.3 27.5 0.2 11.7 27.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein AP3D1 PF06375.11 CRG85653.1 - 0.39 11.0 24.6 0.95 9.7 24.6 1.7 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 RNA_polI_A34 PF08208.11 CRG85653.1 - 0.42 10.7 37.6 0.68 10.0 37.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RP-C_C PF11800.8 CRG85653.1 - 0.42 10.7 10.4 2.8 8.0 0.0 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region DDHD PF02862.17 CRG85653.1 - 3.1 7.9 8.8 6.1 6.9 8.8 1.5 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 CRG85653.1 - 4.4 7.1 22.2 8.7 6.1 22.2 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 CRG85653.1 - 4.5 6.2 26.3 7.8 5.4 26.3 1.3 1 0 0 1 1 1 0 Paf1 GAGA_bind PF06217.12 CRG85653.1 - 5.5 7.2 16.3 3 8.0 13.6 1.9 2 0 0 2 2 2 0 GAGA binding protein-like family CDC45 PF02724.14 CRG85653.1 - 7.4 4.7 23.7 11 4.2 23.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF3767 PF12597.8 CRG85658.1 - 2e-31 107.8 0.1 4.5e-31 106.6 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3767) DUF1744 PF08490.12 CRG85659.1 - 5.8e-152 505.9 0.0 8.7e-152 505.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 CRG85659.1 - 4.6e-81 272.6 0.1 9.5e-81 271.5 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 CRG85659.1 - 2e-13 49.9 0.0 1.2e-10 40.8 0.0 3.5 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 CRG85659.1 - 1.9e-08 34.3 0.1 4.8e-08 33.0 0.1 1.6 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 CRG85659.1 - 6.5e-05 23.0 0.0 0.00023 21.2 0.0 1.9 1 0 0 1 1 1 1 RNase_H superfamily zf-MIZ PF02891.20 CRG85659.1 - 0.43 10.4 2.8 9.1 6.1 0.3 2.7 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger Pkinase PF00069.25 CRG85660.1 - 6e-73 245.4 0.0 7.7e-73 245.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85660.1 - 2e-29 102.7 0.0 2.9e-29 102.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG85660.1 - 4.2e-07 29.6 0.0 6.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CRG85660.1 - 0.00013 20.9 0.0 0.00024 20.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CRG85660.1 - 0.00032 20.7 0.0 0.00053 20.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG85660.1 - 0.0004 19.8 0.1 0.00068 19.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family MFS_1 PF07690.16 CRG85661.1 - 8.8e-05 21.6 17.6 8.8e-05 21.6 17.6 4.3 2 2 2 5 5 5 3 Major Facilitator Superfamily Sh_2 PF17512.2 CRG85661.1 - 2.9 7.6 4.2 32 4.2 0.4 2.5 2 0 0 2 2 2 0 Metapneumovirus Small hydrophobic protein AMMECR1 PF01871.17 CRG85663.1 - 7.5e-42 142.8 0.0 1.7e-41 141.6 0.0 1.6 2 0 0 2 2 2 1 AMMECR1 SGT1 PF07093.11 CRG85664.1 - 5.6e-99 332.2 13.2 6.5e-88 295.6 0.0 2.1 1 1 1 2 2 2 2 SGT1 protein IreB PF06135.12 CRG85664.1 - 0.051 13.8 0.0 9.1 6.6 0.0 2.6 2 0 0 2 2 2 0 IreB regulatory phosphoprotein Cnn_1N PF07989.11 CRG85665.1 - 2.2e-22 79.0 7.3 2.2e-22 79.0 7.3 17.0 5 3 11 17 17 17 1 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 CRG85665.1 - 2.3e-21 76.2 1.4 2.3e-21 76.2 1.4 5.8 7 2 0 7 7 7 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc110_C PF18520.1 CRG85665.1 - 0.00018 21.1 0.1 0.0016 18.0 0.1 2.8 1 0 0 1 1 1 1 Spindle pole body component 110 C-terminal domain GAS PF13851.6 CRG85665.1 - 0.0012 18.3 29.4 0.0012 18.3 29.4 10.2 2 2 8 11 11 11 4 Growth-arrest specific micro-tubule binding Halo_GVPC PF05465.13 CRG85665.1 - 0.047 13.9 4.6 0.088 13.1 0.3 3.6 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat Fez1 PF06818.15 CRG85665.1 - 0.26 11.7 182.6 1 9.8 32.1 7.9 1 1 5 7 7 7 0 Fez1 Spc7 PF08317.11 CRG85665.1 - 1.6 7.5 191.0 0.0059 15.5 21.9 7.9 2 2 7 9 9 9 0 Spc7 kinetochore protein ArabFuran-catal PF09206.11 CRG85667.1 - 5.2e-144 479.4 8.4 5.2e-144 479.4 8.4 1.4 2 0 0 2 2 2 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 CRG85667.1 - 5.3e-55 185.3 3.0 7.8e-55 184.7 3.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain AAA PF00004.29 CRG85668.1 - 4.8e-42 143.5 0.0 1e-41 142.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CRG85668.1 - 1.1e-30 105.3 0.1 7.9e-30 102.7 0.0 2.4 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 CRG85668.1 - 3.7e-23 81.4 2.2 3.7e-23 81.4 2.2 1.9 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 CRG85668.1 - 1.6e-05 24.7 0.0 3.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CRG85668.1 - 5.6e-05 23.5 0.0 0.015 15.7 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 CRG85668.1 - 7.2e-05 22.8 0.0 0.00033 20.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG85668.1 - 0.00013 22.4 0.0 0.0018 18.7 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 CRG85668.1 - 0.00014 21.7 0.0 0.00032 20.5 0.0 1.6 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 CRG85668.1 - 0.00014 22.0 0.1 0.0066 16.6 0.0 2.7 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 CRG85668.1 - 0.00016 21.0 0.0 0.00029 20.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 CRG85668.1 - 0.00016 20.9 0.0 0.0013 18.0 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_lid_3 PF17862.1 CRG85668.1 - 0.00037 20.3 0.0 0.0025 17.6 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_22 PF13401.6 CRG85668.1 - 0.00055 20.2 0.1 0.088 13.1 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 CRG85668.1 - 0.00058 20.0 0.0 0.0015 18.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CRG85668.1 - 0.00062 19.8 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG85668.1 - 0.0024 18.4 0.3 0.016 15.8 0.0 2.4 3 1 0 3 3 2 1 AAA domain AAA_17 PF13207.6 CRG85668.1 - 0.006 17.0 0.0 0.036 14.5 0.0 2.4 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 CRG85668.1 - 0.0061 16.3 0.2 0.026 14.2 0.0 2.2 3 0 0 3 3 2 1 AAA domain Mg_chelatase PF01078.21 CRG85668.1 - 0.0086 15.5 0.2 0.032 13.6 0.1 2.0 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI USP8_dimer PF08969.11 CRG85668.1 - 0.018 15.2 2.1 0.041 14.1 2.1 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain AAA_7 PF12775.7 CRG85668.1 - 0.019 14.5 0.1 0.13 11.8 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region Torsin PF06309.11 CRG85668.1 - 0.038 14.1 0.1 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Torsin AAA_25 PF13481.6 CRG85668.1 - 0.043 13.4 0.2 3.1 7.3 0.1 2.8 2 1 0 3 3 3 0 AAA domain PhoH PF02562.16 CRG85668.1 - 0.045 13.2 0.1 0.11 11.9 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 CRG85668.1 - 0.079 12.9 0.1 2 8.3 0.0 2.5 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea Use1 PF09753.9 CRG85668.1 - 0.085 12.6 1.3 0.15 11.7 1.3 1.4 1 0 0 1 1 1 0 Membrane fusion protein Use1 Parvo_NS1 PF01057.17 CRG85668.1 - 0.086 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 CRG85668.1 - 0.089 12.1 0.2 0.95 8.7 0.0 2.6 2 1 1 3 3 3 0 Zeta toxin AFG1_ATPase PF03969.16 CRG85668.1 - 0.12 11.2 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 AFG1-like ATPase NACHT PF05729.12 CRG85668.1 - 0.15 12.0 0.0 1.3 8.9 0.0 2.1 1 1 1 2 2 2 0 NACHT domain Cytidylate_kin PF02224.18 CRG85668.1 - 0.26 11.0 2.3 0.65 9.7 0.0 2.7 3 1 1 4 4 4 0 Cytidylate kinase EF-1_beta_acid PF10587.9 CRG85668.1 - 0.4 11.2 4.7 0.17 12.3 1.4 2.2 2 0 0 2 2 1 0 Eukaryotic elongation factor 1 beta central acidic region TPR_1 PF00515.28 CRG85668.1 - 0.9 9.5 4.0 0.38 10.7 0.5 2.4 3 0 0 3 3 1 0 Tetratricopeptide repeat Prefoldin_2 PF01920.20 CRG85669.1 - 8.3e-23 80.4 16.4 1.1e-22 80.0 16.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit Spc24 PF08286.11 CRG85669.1 - 0.00034 20.8 12.7 0.051 13.8 2.7 2.1 2 0 0 2 2 2 2 Spc24 subunit of Ndc80 Spc7 PF08317.11 CRG85669.1 - 0.0043 16.0 17.1 0.0053 15.7 17.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Rh5 PF18515.1 CRG85669.1 - 0.0083 15.4 2.6 0.01 15.1 2.6 1.3 1 0 0 1 1 1 1 Rh5 coiled-coil domain Prefoldin_3 PF13758.6 CRG85669.1 - 0.0092 16.0 5.5 0.0092 16.0 5.5 1.3 1 1 0 1 1 1 1 Prefoldin subunit CENP-F_leu_zip PF10473.9 CRG85669.1 - 0.01 15.8 15.1 0.24 11.4 3.3 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 XhlA PF10779.9 CRG85669.1 - 0.019 15.2 2.6 0.019 15.2 2.6 2.4 2 1 0 2 2 2 0 Haemolysin XhlA Rx_N PF18052.1 CRG85669.1 - 0.057 13.7 9.4 0.43 10.9 2.0 2.2 2 0 0 2 2 2 0 Rx N-terminal domain EzrA PF06160.12 CRG85669.1 - 0.073 11.2 15.6 0.24 9.5 6.0 2.0 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA PHM7_cyt PF14703.6 CRG85669.1 - 0.084 13.1 9.1 0.15 12.2 9.1 1.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter HalX PF08663.10 CRG85669.1 - 0.093 13.1 7.2 0.22 11.9 0.3 2.7 2 2 0 2 2 2 0 HalX domain TMF_TATA_bd PF12325.8 CRG85669.1 - 0.14 12.4 15.6 0.33 11.2 4.9 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DHR10 PF18595.1 CRG85669.1 - 0.18 11.9 20.7 0.096 12.7 3.9 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain betaPIX_CC PF16523.5 CRG85669.1 - 0.25 11.2 6.9 0.27 11.1 1.1 2.3 2 0 0 2 2 2 0 betaPIX coiled coil DUF4201 PF13870.6 CRG85669.1 - 0.29 10.8 14.2 0.73 9.5 2.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 CRG85669.1 - 0.31 11.5 11.9 0.92 10.0 2.8 2.2 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 CRG85669.1 - 0.46 10.3 21.0 0.11 12.3 4.0 3.1 2 1 1 3 3 3 0 Septum formation initiator RPW8 PF05659.11 CRG85669.1 - 0.48 10.1 9.2 2.5 7.8 3.2 2.0 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 SKA2 PF16740.5 CRG85669.1 - 0.48 10.2 13.2 0.58 10.0 1.6 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Prefoldin PF02996.17 CRG85669.1 - 0.72 9.8 17.5 21 5.1 17.5 2.3 1 1 0 1 1 1 0 Prefoldin subunit ERM PF00769.19 CRG85669.1 - 0.81 9.5 17.8 1.3 8.8 17.8 1.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4349 PF14257.6 CRG85669.1 - 0.82 9.1 16.7 1.4 8.3 4.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Spectrin PF00435.21 CRG85669.1 - 0.86 10.1 14.9 0.88 10.1 4.7 2.3 1 1 0 2 2 2 0 Spectrin repeat FlaC_arch PF05377.11 CRG85669.1 - 0.94 9.9 10.2 3.3 8.2 1.6 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 CRG85669.1 - 0.97 9.9 16.6 0.89 10.0 7.2 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Fez1 PF06818.15 CRG85669.1 - 1 9.8 14.5 1.1 9.7 5.2 2.1 1 1 1 2 2 2 0 Fez1 TPR_MLP1_2 PF07926.12 CRG85669.1 - 1.3 9.1 21.2 0.8 9.8 4.4 2.6 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Csm1_N PF18504.1 CRG85669.1 - 1.5 9.2 18.0 1.8 9.0 0.8 3.7 2 2 1 3 3 3 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 CRG85669.1 - 1.6 9.1 19.0 2.1 8.7 6.4 3.2 2 2 1 3 3 3 0 ABC transporter C-terminal domain Tropomyosin_1 PF12718.7 CRG85669.1 - 1.6 8.9 17.1 1.9 8.6 4.0 2.1 2 0 0 2 2 2 0 Tropomyosin like Rootletin PF15035.6 CRG85669.1 - 1.7 8.6 13.2 0.57 10.2 6.5 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion End3 PF12761.7 CRG85669.1 - 1.8 8.7 12.4 3 8.0 12.4 1.3 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Siah-Interact_N PF09032.11 CRG85669.1 - 2.3 8.6 19.4 6.3 7.2 5.3 2.7 1 1 1 2 2 2 0 Siah interacting protein, N terminal Nup88 PF10168.9 CRG85669.1 - 2.3 5.9 15.4 2.7 5.7 15.4 1.1 1 0 0 1 1 1 0 Nuclear pore component Sec34 PF04136.15 CRG85669.1 - 2.4 8.0 11.9 1.1 9.1 1.7 2.1 2 0 0 2 2 2 0 Sec34-like family Allexi_40kDa PF05549.11 CRG85669.1 - 2.8 7.4 9.6 5.1 6.5 1.4 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein Fib_alpha PF08702.10 CRG85669.1 - 3 8.0 16.6 22 5.2 16.6 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family YabA PF06156.13 CRG85669.1 - 3.3 8.4 12.6 3.9 8.2 3.3 2.1 1 1 1 2 2 2 0 Initiation control protein YabA APG6_N PF17675.1 CRG85669.1 - 4 8.0 21.7 8 7.0 7.8 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF948 PF06103.11 CRG85669.1 - 5.7 7.3 8.1 8.4 6.7 0.8 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF2203 PF09969.9 CRG85669.1 - 5.8 7.7 11.2 33 5.2 11.2 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Fmp27_WPPW PF10359.9 CRG85669.1 - 5.9 5.6 15.9 1.9 7.3 5.7 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain PRKG1_interact PF15898.5 CRG85669.1 - 7.6 7.5 16.2 4.9 8.1 4.6 2.4 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Osmo_CC PF08946.10 CRG85669.1 - 8.5 6.7 15.2 0.87 9.9 5.1 2.4 2 0 0 2 2 2 0 Osmosensory transporter coiled coil UPF0242 PF06785.11 CRG85669.1 - 9.9 6.2 19.4 22 5.1 19.4 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus iPGM_N PF06415.13 CRG85671.1 - 4.6e-76 255.0 0.0 6.6e-76 254.5 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 CRG85671.1 - 3.9e-73 245.9 0.0 4.5e-73 245.7 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CRG85671.1 - 2.2e-07 30.6 0.0 1.4e-06 28.0 0.0 2.0 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CRG85671.1 - 3.9e-06 26.7 0.0 6.4e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Alk_phosphatase PF00245.20 CRG85671.1 - 0.018 14.1 0.1 0.037 13.0 0.1 1.5 1 0 0 1 1 1 0 Alkaline phosphatase Med9 PF07544.13 CRG85672.1 - 6.5e-19 67.8 0.0 1.8e-18 66.4 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase II transcription mediator complex subunit 9 SARAF PF06682.12 CRG85672.1 - 0.0046 16.7 1.0 0.0046 16.7 1.0 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis DUF104 PF01954.16 CRG85672.1 - 0.016 15.7 0.6 0.023 15.1 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF104 XhlA PF10779.9 CRG85672.1 - 0.081 13.1 0.2 0.13 12.5 0.2 1.3 1 0 0 1 1 1 0 Haemolysin XhlA GP41 PF00517.17 CRG85672.1 - 0.24 11.3 0.2 0.34 10.8 0.2 1.2 1 0 0 1 1 1 0 Retroviral envelope protein SlyX PF04102.12 CRG85672.1 - 0.37 11.5 0.1 0.37 11.5 0.1 2.5 2 0 0 2 2 2 0 SlyX LUC7 PF03194.15 CRG85672.1 - 1.4 8.5 3.8 0.41 10.3 0.7 1.6 2 0 0 2 2 2 0 LUC7 N_terminus Ndc1_Nup PF09531.10 CRG85672.1 - 3.7 6.1 4.5 4.6 5.8 4.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DivIC PF04977.15 CRG85672.1 - 9 6.2 6.8 0.33 10.8 0.3 1.9 2 0 0 2 2 2 0 Septum formation initiator PRIMA1 PF16101.5 CRG85672.1 - 9.1 6.3 10.9 0.17 11.9 3.8 1.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 SHMT PF00464.19 CRG85673.1 - 4.4e-205 680.8 0.0 5.2e-205 680.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 CRG85673.1 - 0.027 13.8 0.0 0.051 12.8 0.0 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase FR47 PF08445.10 CRG85673.1 - 0.048 13.6 0.0 0.13 12.2 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein Baculo_DNA_bind PF04786.12 CRG85673.1 - 0.077 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 ssDNA binding protein CCDC50_N PF15295.6 CRG85673.1 - 0.45 10.7 2.5 2.8 8.1 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 50 N-terminus Prenylcys_lyase PF07156.14 CRG85674.1 - 6.5e-96 321.6 0.0 1e-95 321.0 0.0 1.2 1 0 0 1 1 1 1 Prenylcysteine lyase GRAM PF02893.20 CRG85674.1 - 1.1e-32 112.3 0.4 1.3e-20 73.3 0.0 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 CRG85674.1 - 7.5e-27 94.1 0.0 1.6e-26 93.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 CRG85674.1 - 3.5e-14 53.2 0.1 2.9e-12 47.0 0.0 3.5 4 0 0 4 4 4 1 PH domain NAD_binding_8 PF13450.6 CRG85674.1 - 3.7e-11 43.1 0.0 1.1e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CRG85674.1 - 1.6e-09 37.6 0.0 1.1e-08 34.8 0.0 2.1 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase PH_8 PF15409.6 CRG85674.1 - 4.8e-06 26.8 0.0 1.4e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain DAO PF01266.24 CRG85674.1 - 8.3e-05 22.3 0.0 0.17 11.4 0.0 2.7 3 0 0 3 3 3 2 FAD dependent oxidoreductase PH_11 PF15413.6 CRG85674.1 - 0.00048 20.5 0.2 0.0021 18.5 0.2 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 CRG85674.1 - 0.00062 19.8 0.0 0.0013 18.8 0.0 1.5 1 0 0 1 1 1 1 PH domain UDPGT PF00201.18 CRG85674.1 - 0.0096 14.8 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_6 PF15406.6 CRG85674.1 - 0.081 13.2 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain PH_2 PF08458.10 CRG85674.1 - 0.19 12.1 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PDCD2_C PF04194.13 CRG85677.1 - 2.6e-45 154.6 0.1 1e-43 149.4 0.0 2.4 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain A2L_zn_ribbon PF08792.10 CRG85677.1 - 0.47 10.2 3.2 0.56 10.0 0.1 2.4 3 0 0 3 3 3 0 A2L zinc ribbon domain SR-25 PF10500.9 CRG85677.1 - 2.8 7.5 7.1 4.7 6.8 7.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CLP1_P PF16575.5 CRG85679.1 - 2.2e-26 92.8 0.0 9e-26 90.8 0.0 2.1 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop BNIP3 PF06553.12 CRG85679.1 - 0.002 17.9 0.4 0.0047 16.6 0.4 1.7 1 0 0 1 1 1 1 BNIP3 AAA_22 PF13401.6 CRG85679.1 - 0.023 15.0 0.0 0.088 13.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CRG85679.1 - 0.035 14.3 0.7 0.37 11.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CRG85679.1 - 0.097 13.2 0.8 0.32 11.5 0.0 2.3 2 1 1 3 3 3 0 AAA domain RNA_helicase PF00910.22 CRG85679.1 - 0.11 13.0 0.2 0.36 11.3 0.0 2.0 2 0 0 2 2 2 0 RNA helicase RNA_polI_A34 PF08208.11 CRG85680.1 - 1.2e-36 126.7 27.8 1.2e-36 126.7 27.8 2.8 2 1 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 CRG85680.1 - 0.26 9.5 27.2 0.05 11.9 13.3 2.1 2 0 0 2 2 2 0 CDC45-like protein DDHD PF02862.17 CRG85680.1 - 2.9 8.0 14.1 4 7.5 0.8 2.2 2 0 0 2 2 2 0 DDHD domain DUF1682 PF07946.14 CRG85680.1 - 4.2 6.5 18.9 5.6 6.1 18.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Folliculin PF11704.8 CRG85681.1 - 7.1e-52 176.0 0.0 1.2e-51 175.2 0.0 1.4 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport CSN8_PSD8_EIF3K PF10075.9 CRG85682.1 - 1.9e-50 170.6 0.0 2.4e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Prefoldin PF02996.17 CRG85683.1 - 4.8e-30 103.9 2.1 4.8e-30 103.9 2.1 1.4 2 0 0 2 2 2 1 Prefoldin subunit Prefoldin_2 PF01920.20 CRG85683.1 - 0.002 18.1 0.7 0.002 18.1 0.7 2.1 1 1 1 2 2 2 1 Prefoldin subunit Laminin_II PF06009.12 CRG85683.1 - 0.016 15.2 0.4 0.58 10.2 0.1 2.1 2 0 0 2 2 2 0 Laminin Domain II LMP PF04778.12 CRG85683.1 - 0.035 14.0 4.0 0.33 10.8 4.0 2.5 1 1 0 1 1 1 0 LMP repeated region DUF4201 PF13870.6 CRG85683.1 - 0.059 13.1 5.0 0.12 12.1 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) End3 PF12761.7 CRG85683.1 - 0.068 13.3 2.2 0.16 12.1 2.0 1.7 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 FlaC_arch PF05377.11 CRG85683.1 - 1.2 9.6 4.9 3.2 8.2 0.1 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Vma12 PF11712.8 CRG85684.1 - 1.1e-38 132.5 0.0 1.5e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase ATP-synt_I PF03899.15 CRG85684.1 - 0.038 14.3 0.3 2 8.8 0.1 2.2 2 0 0 2 2 2 0 ATP synthase I chain FAM176 PF14851.6 CRG85684.1 - 0.13 12.0 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 FAM176 family ATPase_gene1 PF09527.10 CRG85684.1 - 0.4 10.9 3.0 18 5.6 0.3 2.2 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter LapA_dom PF06305.11 CRG85684.1 - 1.7 8.5 4.4 0.66 9.8 0.1 2.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Amidohydro_1 PF01979.20 CRG85685.1 - 2.7e-28 99.3 0.0 2.6e-27 96.0 0.0 2.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG85685.1 - 9.6e-12 45.1 0.3 1.8e-06 27.8 0.0 2.5 3 0 0 3 3 3 2 Amidohydrolase family Ribosomal_S14 PF00253.21 CRG85687.1 - 7.9e-20 70.4 0.5 2.3e-19 68.9 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e DASH_Spc19 PF08287.11 CRG85689.1 - 5.2e-53 179.1 6.2 7e-53 178.7 6.2 1.2 1 0 0 1 1 1 1 Spc19 Mur_ligase_M PF08245.12 CRG85689.1 - 0.0054 16.7 0.0 0.0059 16.6 0.0 1.3 1 0 0 1 1 1 1 Mur ligase middle domain Rsm22 PF09243.10 CRG85690.1 - 1.6e-30 106.4 0.0 2.4e-29 102.5 0.0 2.8 2 1 0 2 2 2 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 CRG85690.1 - 0.0046 16.8 0.0 0.017 15.0 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Uricase PF01014.18 CRG85690.1 - 0.12 12.6 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 Uricase Rogdi_lz PF10259.9 CRG85691.1 - 4.4e-86 288.7 0.4 5e-86 288.5 0.4 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein SUR7 PF06687.12 CRG85692.1 - 2e-41 142.0 13.6 2.3e-41 141.8 13.6 1.0 1 0 0 1 1 1 1 SUR7/PalI family Clc-like PF07062.12 CRG85692.1 - 0.0016 17.9 1.0 0.0016 17.9 1.0 1.6 3 0 0 3 3 3 1 Clc-like DUF4064 PF13273.6 CRG85692.1 - 0.0028 17.9 5.2 0.089 13.1 0.2 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF4064) Amastin PF07344.11 CRG85692.1 - 1.6 8.6 18.1 0.59 10.0 12.1 2.2 1 1 1 2 2 2 0 Amastin surface glycoprotein HSP70 PF00012.20 CRG85695.1 - 1.5e-85 287.6 1.2 1.5e-85 287.6 1.2 1.7 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CRG85695.1 - 3.3e-09 36.0 0.3 5.4e-09 35.3 0.3 1.4 1 0 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 CRG85695.1 - 0.0019 17.3 0.0 2.1 7.3 0.0 2.6 2 1 0 2 2 2 2 Type IV pilus assembly protein PilM; Peripla_BP_6 PF13458.6 CRG85695.1 - 0.0023 17.6 1.3 0.0033 17.2 0.1 1.8 2 1 1 3 3 3 1 Periplasmic binding protein Inhibitor_I71 PF12628.7 CRG85695.1 - 0.12 12.2 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor RXT2_N PF08595.11 CRG85695.1 - 0.22 11.6 2.3 0.42 10.6 2.3 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 CRG85695.1 - 0.38 10.5 5.6 0.65 9.7 5.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 CRG85695.1 - 2.9 5.9 5.8 4.2 5.3 5.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi SIP PF04954.13 CRG85695.1 - 3 8.4 4.9 19 5.8 0.1 3.4 3 0 0 3 3 3 0 Siderophore-interacting protein KH_6 PF15985.5 CRG85696.1 - 1.3e-17 63.8 0.0 3.1e-17 62.7 0.0 1.6 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 CRG85696.1 - 0.00071 19.5 3.8 0.0027 17.6 3.8 2.0 1 1 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain DUF4394 PF14339.6 CRG85696.1 - 0.037 13.4 0.3 0.72 9.2 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4394) IMUP PF15761.5 CRG85696.1 - 3.4 8.4 9.0 0.57 10.9 3.7 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein Myb_DNA-bind_6 PF13921.6 CRG85697.1 - 1.6e-17 63.5 6.0 6.4e-13 48.7 1.4 3.6 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG85697.1 - 4.2e-17 62.1 11.5 3.8e-08 33.4 0.2 4.0 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 CRG85697.1 - 0.0011 19.3 2.8 0.0058 17.0 0.1 2.9 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 CRG85697.1 - 0.074 13.3 0.3 13 6.1 0.0 2.5 1 1 1 2 2 2 0 SANT/Myb-like domain of DAMP1 Glyco_transf_24 PF18404.1 CRG85698.1 - 2.2e-147 489.6 1.3 3.6e-147 488.9 1.3 1.4 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 CRG85698.1 - 1.4e-66 225.0 0.2 4.5e-64 216.8 0.0 2.8 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_12 PF18400.1 CRG85698.1 - 6.6e-48 163.1 0.0 1.8e-47 161.7 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 CRG85698.1 - 5.3e-44 150.7 0.2 1.6e-42 145.8 0.1 2.6 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 CRG85698.1 - 3.1e-40 136.7 0.0 6.5e-40 135.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 CRG85698.1 - 1.7e-39 134.9 0.6 6.2e-38 129.8 0.0 3.0 3 0 0 3 3 3 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 CRG85698.1 - 0.00071 19.2 0.1 0.0028 17.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family 8 DUF1416 PF07210.12 CRG85698.1 - 0.013 15.3 0.1 0.27 11.1 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1416) HTH_43 PF09904.9 CRG85699.1 - 0.14 12.1 0.3 0.55 10.2 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn helix Rpp20 PF12328.8 CRG85700.1 - 2.9e-41 140.6 16.4 2.9e-40 137.4 16.4 2.6 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 CRG85700.1 - 2.4e-15 56.1 0.0 4.5e-15 55.2 0.0 1.5 1 1 0 1 1 1 1 Alba CDC45 PF02724.14 CRG85700.1 - 3.6 5.8 18.6 0.07 11.4 11.1 1.7 1 1 1 2 2 2 0 CDC45-like protein REV PF00424.18 CRG85700.1 - 7.5 6.6 13.9 0.48 10.5 7.6 2.1 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) FHA PF00498.26 CRG85701.1 - 4.4e-16 59.0 0.1 9.3e-16 57.9 0.1 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CRG85701.1 - 0.00013 22.2 0.0 0.00037 20.8 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain ZnuA PF01297.17 CRG85701.1 - 0.037 13.4 3.4 0.4 10.0 0.0 2.2 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic Hormone_1 PF00103.20 CRG85701.1 - 0.38 10.5 5.2 0.083 12.6 1.3 1.8 2 0 0 2 2 2 0 Somatotropin hormone family VGCC_beta4Aa_N PF12052.8 CRG85701.1 - 0.63 10.2 7.5 3.8 7.7 1.2 3.3 2 0 0 2 2 2 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal Helicase_IV_N PF12462.8 CRG85701.1 - 0.84 9.6 7.6 2.2 8.2 0.7 2.5 2 0 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal TPR_MLP1_2 PF07926.12 CRG85701.1 - 1.5 8.9 30.8 0.28 11.2 9.8 3.6 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 CRG85701.1 - 1.9 5.9 30.7 0.035 11.7 22.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) YabA PF06156.13 CRG85701.1 - 2.1 9.0 17.4 1.2 9.8 5.2 3.6 3 0 0 3 3 3 0 Initiation control protein YabA LMBR1 PF04791.16 CRG85701.1 - 2.1 7.2 9.1 0.64 8.9 0.2 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein Borrelia_P83 PF05262.11 CRG85701.1 - 3.5 6.0 17.8 7 5.0 17.9 1.4 1 1 0 1 1 1 0 Borrelia P83/100 protein Spectrin PF00435.21 CRG85701.1 - 6.3 7.3 18.2 3.1 8.3 6.2 3.1 3 0 0 3 3 3 0 Spectrin repeat DUF3037 PF11236.8 CRG85701.1 - 6.4 7.2 7.5 1.1 9.7 2.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) LMP PF04778.12 CRG85701.1 - 7.9 6.4 13.5 0.059 13.3 2.6 2.7 3 0 0 3 3 3 0 LMP repeated region Romo1 PF10247.9 CRG85702.1 - 1e-26 93.1 18.6 1.2e-26 92.8 18.6 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 CRG85702.1 - 0.0095 16.3 4.9 0.011 16.0 4.9 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CBP_BcsO PF17037.5 CRG85704.1 - 3.3 7.8 11.5 4.1 7.5 10.9 1.5 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsO Ferric_reduct PF01794.19 CRG85705.1 - 2.7e-23 82.4 5.5 6.1e-23 81.3 5.5 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG85705.1 - 4.8e-22 78.8 0.0 7.8e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG85705.1 - 2.5e-11 43.6 0.0 4.7e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Cyt_bd_oxida_II PF02322.15 CRG85705.1 - 0.11 11.8 9.1 0.096 12.0 7.4 1.6 1 1 0 1 1 1 0 Cytochrome bd terminal oxidase subunit II DUF202 PF02656.15 CRG85705.1 - 0.12 12.8 5.8 2.9 8.4 2.0 3.2 1 1 1 2 2 2 0 Domain of unknown function (DUF202) Ni_hydr_CYTB PF01292.20 CRG85705.1 - 0.8 9.3 7.8 2.6 7.6 7.8 1.8 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 LRR_8 PF13855.6 CRG85706.1 - 1.6e-09 37.4 6.3 1.6e-09 37.4 6.3 2.0 2 0 0 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 CRG85706.1 - 1.9e-06 28.1 1.7 1.9e-06 28.1 1.7 3.0 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 CRG85706.1 - 9.5 7.2 9.5 64 4.7 0.0 4.8 4 0 0 4 4 4 0 Leucine Rich Repeat EI24 PF07264.11 CRG85707.1 - 1e-11 45.4 5.0 1.6e-11 44.8 5.0 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) zf-RING_2 PF13639.6 CRG85708.1 - 7.5e-13 48.6 5.3 1.2e-12 48.0 5.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CRG85708.1 - 3.6e-09 36.2 2.4 3.6e-09 36.2 2.4 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CRG85708.1 - 4.8e-09 35.9 4.8 7.7e-09 35.3 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CRG85708.1 - 8.8e-09 35.5 2.9 1.9e-08 34.5 2.9 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CRG85708.1 - 1e-08 34.9 3.5 1.7e-08 34.2 3.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 CRG85708.1 - 2e-08 34.2 0.0 6.5e-08 32.5 0.0 1.9 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.6 CRG85708.1 - 2.1e-07 30.8 2.8 3.3e-07 30.2 2.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CRG85708.1 - 3.8e-06 26.7 2.8 5.6e-06 26.1 2.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG85708.1 - 5.5e-06 26.3 2.1 9.9e-06 25.5 0.4 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 CRG85708.1 - 0.00086 19.3 0.8 0.0016 18.4 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CRG85708.1 - 0.0015 18.4 2.8 0.0025 17.6 2.8 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 CRG85708.1 - 0.014 15.0 2.8 0.026 14.1 2.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 CRG85708.1 - 0.026 14.7 1.9 0.066 13.4 1.9 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 CRG85708.1 - 0.05 13.8 2.7 0.13 12.4 2.7 1.7 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 CRG85708.1 - 0.21 11.4 3.3 0.37 10.6 3.3 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 CRG85708.1 - 0.3 11.0 3.2 0.54 10.2 3.2 1.5 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.7 CRG85708.1 - 0.32 11.2 4.0 0.6 10.3 4.0 1.5 1 0 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 CRG85708.1 - 0.76 10.1 3.8 1.4 9.3 3.8 1.5 1 0 0 1 1 1 0 RING-like domain Phage_GPO PF05929.11 CRG85709.1 - 0.061 12.9 2.3 0.1 12.2 2.3 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase ZapB PF06005.12 CRG85709.1 - 0.08 13.4 0.4 0.08 13.4 0.4 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DUF789 PF05623.12 CRG85709.1 - 7 6.2 6.8 0.28 10.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF789) UAA PF08449.11 CRG85710.1 - 8.4e-42 143.4 12.4 1.3e-41 142.8 12.4 1.2 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 CRG85710.1 - 1.2e-07 31.2 2.4 0.0029 16.8 0.1 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 CRG85710.1 - 1.2e-06 28.7 27.1 2.6e-05 24.4 7.1 3.1 3 1 0 3 3 3 2 EamA-like transporter family TPT PF03151.16 CRG85710.1 - 0.0011 18.4 7.0 0.048 13.0 0.5 2.2 2 0 0 2 2 2 2 Triose-phosphate Transporter family DUF5090 PF17009.5 CRG85710.1 - 0.91 9.5 10.6 0.56 10.1 1.7 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5090) Sen15 PF09631.10 CRG85712.1 - 2.4e-15 56.6 0.0 8.3e-14 51.7 0.0 2.2 1 1 0 1 1 1 1 Sen15 protein VASt PF16016.5 CRG85714.1 - 2.7e-33 115.5 0.0 5.7e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 CRG85714.1 - 1e-14 54.8 0.0 1.9e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 CRG85714.1 - 7.8e-08 32.8 0.2 4.3e-07 30.4 0.1 2.4 3 0 0 3 3 3 1 PH domain BAR PF03114.18 CRG85714.1 - 0.0065 16.1 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 BAR domain GRAM PF02893.20 CRG85714.1 - 0.014 15.3 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 GRAM domain Kri1_C PF12936.7 CRG85716.1 - 2.5e-31 107.7 0.3 2.5e-31 107.7 0.3 4.5 4 1 1 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 CRG85716.1 - 4.4e-28 97.8 21.7 4.4e-28 97.8 21.7 5.9 5 1 1 6 6 6 1 KRI1-like family Mito_carr PF00153.27 CRG85717.1 - 9.3e-64 211.4 6.6 2.9e-22 78.4 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Stb3 PF10330.9 CRG85720.1 - 7e-39 131.8 0.0 1.2e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein CoA_transf_3 PF02515.17 CRG85721.1 - 5.8e-44 150.7 0.1 5.7e-42 144.1 0.0 2.2 2 0 0 2 2 2 2 CoA-transferase family III Fungal_trans PF04082.18 CRG85723.1 - 3.1e-20 72.3 0.2 5.2e-20 71.6 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85723.1 - 3.7e-07 30.2 9.7 6.4e-07 29.4 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Abhydrolase_1 PF00561.20 CRG85724.1 - 9e-27 94.3 0.1 3.1e-23 82.7 0.1 2.0 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG85724.1 - 8.9e-18 65.7 0.0 1.4e-17 65.1 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG85724.1 - 1.1e-15 57.6 1.3 1.2e-14 54.2 1.3 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 CRG85724.1 - 1.4e-05 24.9 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Chlorophyllase2 PF12740.7 CRG85724.1 - 5.7e-05 22.1 1.5 0.00025 20.1 1.5 1.8 1 1 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 CRG85724.1 - 0.00011 21.7 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 CRG85724.1 - 0.00018 21.4 0.9 0.05 13.4 0.1 2.4 1 1 1 2 2 2 2 Phospholipase/Carboxylesterase DLH PF01738.18 CRG85724.1 - 0.00025 20.7 0.1 0.24 10.9 0.0 2.1 2 0 0 2 2 2 2 Dienelactone hydrolase family PAF-AH_p_II PF03403.13 CRG85724.1 - 0.0013 17.3 1.0 0.032 12.7 0.1 2.1 2 0 0 2 2 2 1 Platelet-activating factor acetylhydrolase, isoform II Ser_hydrolase PF06821.13 CRG85724.1 - 0.002 18.0 0.0 0.0073 16.2 0.0 1.9 2 0 0 2 2 2 1 Serine hydrolase Chlorophyllase PF07224.11 CRG85724.1 - 0.0022 17.1 1.0 0.003 16.6 0.1 1.6 2 0 0 2 2 2 1 Chlorophyllase DUF915 PF06028.11 CRG85724.1 - 0.004 16.5 0.1 0.045 13.1 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) LIDHydrolase PF10230.9 CRG85724.1 - 0.0056 16.3 0.0 0.012 15.2 0.0 1.4 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase BAAT_C PF08840.11 CRG85724.1 - 0.0073 16.2 0.1 0.028 14.4 0.1 1.8 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DUF676 PF05057.14 CRG85724.1 - 0.0077 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_5 PF12695.7 CRG85724.1 - 0.0078 16.0 0.0 0.045 13.5 0.1 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Ndr PF03096.14 CRG85724.1 - 0.01 14.6 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 0 Ndr family Thioesterase PF00975.20 CRG85724.1 - 0.012 15.8 0.0 0.013 15.6 0.0 1.3 1 1 0 1 1 1 0 Thioesterase domain DUF1057 PF06342.12 CRG85724.1 - 0.018 14.1 0.1 0.027 13.5 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Lipase_3 PF01764.25 CRG85724.1 - 0.021 14.7 0.6 0.045 13.6 0.5 1.4 1 1 0 1 1 1 0 Lipase (class 3) Abhydrolase_3 PF07859.13 CRG85724.1 - 0.023 14.5 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 CRG85724.1 - 0.037 13.7 0.3 0.037 13.7 0.3 1.8 2 0 0 2 2 2 0 PGAP1-like protein Dioxygenase_C PF00775.21 CRG85725.1 - 6.7e-48 162.5 0.0 8.8e-48 162.1 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CRG85725.1 - 2.8e-28 97.6 0.1 4.6e-28 96.9 0.1 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CRG85725.1 - 3.2e-07 30.5 0.0 7.9e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Lipase_C PF18067.1 CRG85725.1 - 0.0063 17.0 0.0 0.016 15.7 0.0 1.7 2 0 0 2 2 2 1 Lipase C-terminal domain CarbopepD_reg_2 PF13715.6 CRG85725.1 - 0.011 15.7 0.0 0.31 11.1 0.0 2.4 2 0 0 2 2 2 0 CarboxypepD_reg-like domain SpaA PF17802.1 CRG85725.1 - 0.013 15.8 0.1 0.033 14.5 0.0 1.7 2 0 0 2 2 2 0 Prealbumin-like fold domain FAD_binding_3 PF01494.19 CRG85726.1 - 7.9e-94 314.8 0.0 1.7e-93 313.6 0.0 1.5 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CRG85726.1 - 6.8e-60 201.9 0.0 1.4e-59 200.8 0.0 1.6 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 CRG85726.1 - 8.6e-06 25.2 0.3 0.00013 21.3 0.1 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG85726.1 - 1.8e-05 24.0 0.1 4e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CRG85726.1 - 0.0001 21.6 0.0 0.0029 16.9 0.0 2.4 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 CRG85726.1 - 0.00012 20.9 0.1 0.0002 20.2 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 CRG85726.1 - 0.0004 19.9 0.6 0.0008 18.9 0.2 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 CRG85726.1 - 0.00098 18.3 0.1 0.0033 16.6 0.1 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CRG85726.1 - 0.0048 16.2 0.0 0.0079 15.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG85726.1 - 0.011 16.0 0.0 0.027 14.7 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CRG85726.1 - 0.011 15.0 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CRG85726.1 - 0.047 12.7 0.1 0.096 11.7 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 CRG85726.1 - 0.051 13.2 0.0 0.25 10.9 0.0 2.0 2 0 0 2 2 2 0 FAD dependent oxidoreductase SE PF08491.10 CRG85726.1 - 0.055 12.5 0.0 0.6 9.1 0.0 2.0 1 1 0 1 1 1 0 Squalene epoxidase Pyr_redox PF00070.27 CRG85726.1 - 0.17 12.4 0.0 0.42 11.2 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PTS_2-RNA PF01885.16 CRG85727.1 - 7.9e-61 205.3 0.0 9.8e-61 204.9 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Utp11 PF03998.13 CRG85727.1 - 0.018 15.0 1.7 0.025 14.5 1.7 1.2 1 0 0 1 1 1 0 Utp11 protein RSRP PF17069.5 CRG85727.1 - 0.18 11.3 1.2 0.26 10.8 1.2 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Ribosomal_L7Ae PF01248.26 CRG85729.1 - 1.3e-23 82.6 0.0 1.6e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 CRG85729.1 - 0.00064 19.6 0.0 0.0009 19.1 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain UPF0147 PF03685.13 CRG85729.1 - 0.078 13.0 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) zinc_ribbon_16 PF17034.5 CRG85730.1 - 5.7e-18 65.3 17.1 2.8e-12 46.9 9.9 3.3 1 1 0 2 2 2 2 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 CRG85730.1 - 0.0013 18.3 7.4 0.0013 18.3 7.4 2.6 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 CRG85730.1 - 0.0035 17.6 0.9 0.013 15.7 0.9 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain HrpB1_HrpK PF09613.10 CRG85730.1 - 0.011 15.4 0.4 0.021 14.5 0.4 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB1_HrpK) BAF1_ABF1 PF04684.13 CRG85730.1 - 0.042 12.9 11.2 0.068 12.2 11.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF2076 PF09849.9 CRG85730.1 - 0.045 13.8 6.5 0.11 12.5 6.5 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Menin PF05053.13 CRG85730.1 - 1.5 7.1 7.3 2.2 6.5 7.3 1.1 1 0 0 1 1 1 0 Menin CTU2 PF10288.9 CRG85730.1 - 3.4 7.9 6.9 21 5.4 6.9 2.3 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 NPR3 PF03666.13 CRG85730.1 - 4.4 6.0 7.4 7.1 5.3 7.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Efg1 PF10153.9 CRG85731.1 - 2.2e-31 108.6 9.6 2.2e-31 108.6 9.6 1.8 2 0 0 2 2 2 1 rRNA-processing protein Efg1 F-box-like PF12937.7 CRG85732.1 - 3.5e-11 42.8 0.2 7.7e-11 41.7 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG85732.1 - 1.7e-09 37.3 0.1 5.4e-09 35.7 0.1 2.0 1 0 0 1 1 1 1 F-box domain LRR_6 PF13516.6 CRG85732.1 - 2.8e-08 33.2 5.5 0.074 13.2 0.0 6.9 8 0 0 8 8 8 3 Leucine Rich repeat LRR_4 PF12799.7 CRG85732.1 - 1.8e-07 31.4 1.4 0.15 12.5 0.0 5.0 3 2 2 5 5 5 2 Leucine Rich repeats (2 copies) Zf_RING PF16744.5 CRG85732.1 - 0.024 14.7 0.0 6.5 6.9 0.0 2.6 2 0 0 2 2 2 0 KIAA1045 RING finger LRR_1 PF00560.33 CRG85732.1 - 0.031 14.8 3.6 18 6.4 0.2 5.1 4 0 0 4 4 4 0 Leucine Rich Repeat PRANC PF09372.10 CRG85732.1 - 0.051 13.9 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 PRANC domain KH_1 PF00013.29 CRG85734.1 - 1.8e-39 133.4 10.8 1.7e-16 59.7 0.1 3.6 3 0 0 3 3 3 3 KH domain ADH_zinc_N PF00107.26 CRG85734.1 - 1.4e-15 57.4 0.0 3.1e-15 56.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG85734.1 - 7.4e-11 41.9 0.0 1.8e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain KH_2 PF07650.17 CRG85734.1 - 4.2e-08 32.9 10.5 0.014 15.2 0.9 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 CRG85734.1 - 2.7e-07 30.4 6.6 0.052 13.4 0.3 3.5 3 0 0 3 3 3 3 KH domain Glu_dehyd_C PF16912.5 CRG85734.1 - 0.00014 21.4 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 CRG85734.1 - 0.00027 20.8 0.0 0.0006 19.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated KH_5 PF13184.6 CRG85734.1 - 0.0025 17.9 6.1 0.69 10.0 0.1 3.5 3 0 0 3 3 3 2 NusA-like KH domain ADH_zinc_N_2 PF13602.6 CRG85734.1 - 0.0043 18.1 0.0 0.013 16.6 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CRG85734.1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain BATS PF06968.13 CRG85734.1 - 0.11 12.6 0.0 0.61 10.3 0.0 2.1 2 0 0 2 2 2 0 Biotin and Thiamin Synthesis associated domain DSPc PF00782.20 CRG85737.1 - 9.9e-23 80.4 0.0 7.8e-21 74.3 0.0 2.4 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain bPH_4 PF06713.11 CRG85737.1 - 0.04 14.0 0.0 0.097 12.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial PH domain Methyltransf_31 PF13847.6 CRG85738.1 - 2.9e-14 53.1 0.0 4.2e-09 36.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 CRG85738.1 - 1.2e-08 35.0 0.2 4.5e-08 33.1 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85738.1 - 4.8e-08 33.6 0.1 3.1e-07 31.0 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85738.1 - 5.9e-07 30.2 0.6 4.1e-06 27.4 0.0 2.6 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85738.1 - 1.1e-06 29.2 0.3 0.00018 22.1 0.0 3.1 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_32 PF13679.6 CRG85738.1 - 0.00049 20.1 1.9 0.00076 19.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CRG85738.1 - 0.0019 17.8 0.0 0.0089 15.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CRG85738.1 - 0.012 14.9 0.0 0.028 13.8 0.0 1.5 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family MetW PF07021.12 CRG85738.1 - 0.019 14.5 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RNA_pol_3_Rpc31 PF11705.8 CRG85738.1 - 0.055 13.7 21.8 0.97 9.6 16.9 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PCMT PF01135.19 CRG85738.1 - 0.21 11.3 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CENP-B_dimeris PF09026.10 CRG85738.1 - 0.27 11.7 27.2 0.57 10.6 13.4 3.2 3 1 0 3 3 3 0 Centromere protein B dimerisation domain FAM176 PF14851.6 CRG85738.1 - 0.39 10.4 16.0 2.4 7.8 1.5 2.9 3 0 0 3 3 3 0 FAM176 family Myc_N PF01056.18 CRG85738.1 - 0.4 10.5 13.6 1 9.2 0.1 2.3 2 0 0 2 2 2 0 Myc amino-terminal region Pox_Ag35 PF03286.14 CRG85738.1 - 0.69 9.7 13.4 8.2 6.2 9.1 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein eIF-3c_N PF05470.12 CRG85738.1 - 1.8 6.8 6.6 2.8 6.1 6.6 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2722 PF10846.8 CRG85738.1 - 2 7.2 12.7 6.6 5.5 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2722) Paf1 PF03985.13 CRG85738.1 - 8.7 5.2 15.5 7.1 5.5 0.4 2.2 2 0 0 2 2 2 0 Paf1 Yippee-Mis18 PF03226.14 CRG85739.1 - 7.7e-19 67.9 0.8 9.6e-19 67.5 0.8 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 CRG85739.1 - 0.0077 16.4 0.6 0.011 15.9 0.6 1.3 1 0 0 1 1 1 1 C-terminal domain of RIG-I DUF2039 PF10217.9 CRG85739.1 - 0.041 14.2 1.3 0.23 11.8 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2039) HNH_5 PF14279.6 CRG85739.1 - 0.043 13.7 0.2 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 HNH endonuclease Evr1_Alr PF04777.13 CRG85739.1 - 0.067 13.7 1.1 1.6 9.3 0.2 2.1 1 1 1 2 2 2 0 Erv1 / Alr family Methyltransf_16 PF10294.9 CRG85740.1 - 1.9e-13 50.5 0.0 2.7e-13 50.0 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase zf-C2H2 PF00096.26 CRG85741.1 - 0.01 16.2 5.5 0.015 15.7 3.4 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG85741.1 - 0.11 13.3 3.0 0.43 11.6 3.0 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger DUF3391 PF11871.8 CRG85741.1 - 0.17 12.4 0.5 0.47 11.0 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Ribosomal_L24e PF01246.20 CRG85742.1 - 1.4e-28 98.9 4.4 3.3e-28 97.7 4.4 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e Cu_amine_oxidN3 PF02728.16 CRG85742.1 - 0.063 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Copper amine oxidase, N3 domain Pam16 PF03656.13 CRG85744.1 - 2.5e-07 30.7 0.0 2.7e-07 30.6 0.0 1.2 1 1 0 1 1 1 1 Pam16 DnaJ PF00226.31 CRG85744.1 - 3.6e-05 23.8 0.1 6.1e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.18 CRG85745.1 - 1.4e-24 86.6 0.1 7.6e-24 84.2 0.0 2.2 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85745.1 - 2.4e-09 37.1 12.9 4.3e-09 36.4 12.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M41 PF01434.18 CRG85746.1 - 8.3e-67 224.7 0.0 1.5e-66 223.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 CRG85746.1 - 5.8e-43 146.5 0.0 1.3e-42 145.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG85746.1 - 3.8e-14 52.2 0.1 8.4e-14 51.1 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 CRG85746.1 - 1.9e-10 41.0 0.0 5.2e-10 39.7 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 CRG85746.1 - 0.0003 20.8 0.0 0.00091 19.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG85746.1 - 0.0025 18.2 0.2 0.26 11.7 0.2 3.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CRG85746.1 - 0.0061 16.8 0.1 1.1 9.5 0.1 3.4 4 0 0 4 4 4 1 AAA domain TIP49 PF06068.13 CRG85746.1 - 0.01 15.1 0.1 0.019 14.2 0.1 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain RuvB_N PF05496.12 CRG85746.1 - 0.012 15.3 0.0 0.033 13.9 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Allexi_40kDa PF05549.11 CRG85746.1 - 0.051 13.1 0.2 0.098 12.2 0.2 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein AAA_2 PF07724.14 CRG85746.1 - 0.053 13.6 0.0 0.17 12.0 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF349 PF03993.12 CRG85746.1 - 0.083 13.2 0.2 0.38 11.1 0.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) AAA_33 PF13671.6 CRG85746.1 - 0.12 12.6 0.0 0.72 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF1295 PF06966.12 CRG85747.1 - 1.5e-39 136.0 7.5 2e-39 135.5 7.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Topoisom_bac PF01131.20 CRG85748.1 - 2.9e-105 352.6 0.0 4e-100 335.7 0.0 2.1 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 CRG85748.1 - 1.4e-19 70.2 0.0 3.1e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Toprim domain Spc7 PF08317.11 CRG85749.1 - 0.00065 18.7 49.1 0.02 13.8 17.8 3.6 2 1 1 3 3 3 3 Spc7 kinetochore protein Lebercilin PF15619.6 CRG85749.1 - 1.4 8.6 51.0 2.2 7.9 9.4 5.5 1 1 4 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease FUSC PF04632.12 CRG85749.1 - 2.3 6.7 10.7 0.74 8.3 4.5 2.3 1 1 1 2 2 2 0 Fusaric acid resistance protein family DltD PF04914.12 CRG85749.1 - 3.8 6.8 17.1 0.0087 15.5 4.0 2.6 2 1 1 3 3 3 0 DltD protein DegQ PF08181.11 CRG85749.1 - 6.3 7.0 11.8 2.1 8.5 4.8 3.2 2 1 0 3 3 3 0 DegQ (SacQ) family Laminin_II PF06009.12 CRG85749.1 - 7.3 6.6 41.8 0.34 10.9 5.8 6.1 2 1 5 7 7 7 0 Laminin Domain II APG6_N PF17675.1 CRG85749.1 - 8.2 7.0 46.9 0.034 14.7 5.2 4.9 2 1 1 4 4 4 0 Apg6 coiled-coil region Sugar_tr PF00083.24 CRG85750.1 - 2.6e-73 247.4 18.3 3.4e-73 247.0 18.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG85750.1 - 8.2e-16 57.9 23.1 1.5e-15 57.0 23.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2427 PF10348.9 CRG85750.1 - 0.078 12.8 4.7 0.21 11.4 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF2427) DUF1700 PF08006.11 CRG85750.1 - 0.77 9.3 5.4 1.4 8.4 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1700) DUF4149 PF13664.6 CRG85751.1 - 9.4e-07 29.1 2.2 1.5e-06 28.4 0.6 2.1 2 1 1 3 3 3 1 Domain of unknown function (DUF4149) EIIBC-GUT_C PF07663.11 CRG85751.1 - 0.41 10.8 3.0 2.5 8.3 0.2 2.2 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II C-terminus Ku_PK_bind PF08785.11 CRG85752.1 - 1.2e-37 128.7 0.2 3e-37 127.4 0.2 1.7 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 CRG85752.1 - 2e-31 109.3 0.0 3.9e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CRG85752.1 - 3.6e-14 53.1 0.0 7.4e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 CRG85752.1 - 0.013 16.2 0.6 0.013 16.2 0.6 2.5 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm DUF2408 PF10303.9 CRG85752.1 - 0.04 14.5 0.0 0.19 12.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) VWA PF00092.28 CRG85752.1 - 0.041 14.1 0.2 0.1 12.8 0.2 1.7 1 1 0 1 1 1 0 von Willebrand factor type A domain VWA_2 PF13519.6 CRG85752.1 - 0.052 14.2 0.1 0.19 12.4 0.1 2.0 1 0 0 1 1 1 0 von Willebrand factor type A domain PX PF00787.24 CRG85753.1 - 3e-16 59.4 0.2 6.5e-16 58.3 0.2 1.6 1 0 0 1 1 1 1 PX domain Arcadin_1 PF18653.1 CRG85753.1 - 0.025 14.6 0.3 0.041 13.9 0.3 1.4 1 0 0 1 1 1 0 Arcadin 1 BCIP PF13862.6 CRG85753.1 - 0.058 13.2 3.5 0.063 13.0 1.0 2.1 2 0 0 2 2 2 0 p21-C-terminal region-binding protein Abhydrolase_6 PF12697.7 CRG85755.1 - 0.015 15.9 0.0 0.025 15.2 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 CRG85755.1 - 0.047 13.4 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein UPF0227 PF05728.12 CRG85755.1 - 0.091 12.7 1.7 0.23 11.4 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) SIP1 PF04938.12 CRG85757.1 - 5.7e-10 39.3 0.0 1.8e-07 31.1 0.0 2.9 2 1 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) tRNA-synt_2 PF00152.20 CRG85758.1 - 3.2e-68 230.1 0.2 4.1e-68 229.8 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF1570 PF07607.11 CRG85758.1 - 0.063 13.6 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1570) DUF885 PF05960.11 CRG85758.1 - 0.49 10.0 5.9 0.72 9.4 2.2 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF885) Med3 PF11593.8 CRG85758.1 - 0.79 8.8 5.1 1.2 8.3 5.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal RNA_pol_Rpc4 PF05132.14 CRG85758.1 - 4.8 7.6 5.7 10 6.6 5.7 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Hydrolase_6 PF13344.6 CRG85759.1 - 4.6e-24 84.5 0.0 8.7e-24 83.6 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG85759.1 - 1.6e-17 63.3 0.1 1.1e-16 60.6 0.0 2.5 3 0 0 3 3 3 1 HAD-hyrolase-like Hydrolase PF00702.26 CRG85759.1 - 3.8e-06 27.4 0.1 0.021 15.1 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CRG85759.1 - 0.0024 18.0 0.0 2.9 8.0 0.0 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CRG85759.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase F-box-like PF12937.7 CRG85761.1 - 1.4e-06 28.0 0.3 3e-06 27.0 0.3 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CRG85761.1 - 0.0024 18.2 6.3 5.6 7.5 0.1 4.9 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Adaptin_N PF01602.20 CRG85762.1 - 2e-115 386.3 0.1 2.8e-115 385.9 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 CRG85762.1 - 2.8e-61 206.1 3.9 6.8e-61 204.8 3.9 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 CRG85762.1 - 2.3e-33 114.8 0.8 2.2e-32 111.6 0.1 2.8 3 0 0 3 3 3 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 CRG85762.1 - 8.8e-20 70.9 0.4 2.6e-12 47.0 0.0 5.7 5 1 2 7 7 7 3 HEAT repeats Cnd1 PF12717.7 CRG85762.1 - 7.5e-10 39.1 8.2 0.0016 18.5 0.1 4.9 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CRG85762.1 - 0.00081 19.4 7.6 0.22 11.9 0.1 5.7 7 0 0 7 7 7 1 HEAT repeat HEAT_PBS PF03130.16 CRG85762.1 - 0.014 16.0 2.0 18 6.3 0.0 5.3 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat DUF5010 PF16402.5 CRG85762.1 - 0.15 10.9 0.0 2.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5010) HEAT_EZ PF13513.6 CRG85762.1 - 0.31 11.6 3.0 0.4 11.2 0.4 2.6 3 0 0 3 3 3 0 HEAT-like repeat Phosducin PF02114.16 CRG85763.1 - 1.3e-13 50.6 0.4 1.7e-13 50.1 0.4 1.2 1 0 0 1 1 1 1 Phosducin bZIP_1 PF00170.21 CRG85764.1 - 1.1e-07 31.9 12.7 1.8e-07 31.1 12.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 CRG85764.1 - 2.2e-05 24.4 0.2 2.2e-05 24.4 0.2 2.2 1 1 1 2 2 2 1 Transcription factor PAP1 bZIP_Maf PF03131.17 CRG85764.1 - 0.0013 19.2 9.5 0.0021 18.6 9.5 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor DUF812 PF05667.11 CRG85764.1 - 0.0042 16.0 2.3 0.0056 15.6 2.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) SHE3 PF17078.5 CRG85764.1 - 0.012 15.4 4.5 0.017 14.8 4.5 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_2 PF07716.15 CRG85764.1 - 0.023 14.8 16.6 0.024 14.7 15.0 1.8 1 1 1 2 2 2 0 Basic region leucine zipper DUF4635 PF15466.6 CRG85764.1 - 0.029 13.9 0.2 0.047 13.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) V_ATPase_I PF01496.19 CRG85764.1 - 0.03 12.3 3.2 0.037 11.9 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NOG1_N PF17835.1 CRG85764.1 - 0.054 13.4 0.3 0.088 12.8 0.3 1.3 1 0 0 1 1 1 0 NOG1 N-terminal helical domain ADIP PF11559.8 CRG85764.1 - 0.12 12.4 11.2 0.2 11.8 11.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 CRG85764.1 - 0.14 12.8 2.1 0.19 12.4 1.4 1.5 1 1 0 1 1 1 0 Initiation control protein YabA NRBF2 PF08961.10 CRG85764.1 - 0.14 11.8 3.7 0.27 10.8 3.7 1.5 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator FdhD-NarQ PF02634.15 CRG85764.1 - 0.17 11.5 2.3 0.23 11.1 2.3 1.2 1 0 0 1 1 1 0 FdhD/NarQ family APG6_N PF17675.1 CRG85764.1 - 0.18 12.3 6.3 0.28 11.7 6.3 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region FlaC_arch PF05377.11 CRG85764.1 - 0.21 12.0 0.5 0.42 11.0 0.5 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CHDCT2 PF08074.11 CRG85764.1 - 0.32 11.2 2.6 0.75 9.9 2.5 1.7 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain UPF0242 PF06785.11 CRG85764.1 - 0.77 9.8 5.7 1.2 9.3 5.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 CRG85764.1 - 1 9.2 4.2 2.1 8.2 4.2 1.5 1 0 0 1 1 1 0 Septum formation initiator GvpL_GvpF PF06386.11 CRG85764.1 - 1.6 8.6 7.5 2.5 8.0 7.5 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Pkinase PF00069.25 CRG85766.1 - 7.8e-26 91.0 0.0 1.1e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85766.1 - 1e-13 51.2 0.0 1.5e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG85766.1 - 6e-09 35.2 0.0 9.3e-09 34.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CRG85766.1 - 0.00028 20.9 0.0 0.0022 18.0 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Fungal_trans PF04082.18 CRG85768.1 - 4.7e-06 25.8 0.1 9.4e-06 24.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Kelch_3 PF13415.6 CRG85770.1 - 8e-33 112.1 11.5 2.3e-07 30.9 0.3 6.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 CRG85770.1 - 5.6e-31 106.3 11.4 3.1e-07 30.3 1.2 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 CRG85770.1 - 2.4e-28 97.5 6.1 5.9e-11 42.2 0.5 6.3 5 1 1 6 6 6 4 Kelch motif Kelch_5 PF13854.6 CRG85770.1 - 2.8e-28 97.4 6.5 4.4e-07 29.7 0.2 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_1 PF01344.25 CRG85770.1 - 6.5e-27 92.9 3.5 6e-11 41.8 0.4 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 CRG85770.1 - 2.6e-19 68.4 7.9 1.5e-08 34.3 0.1 6.4 6 1 0 6 6 6 4 Kelch motif TPR_MLP1_2 PF07926.12 CRG85770.1 - 0.0012 19.0 17.0 0.0012 19.0 17.0 8.8 7 2 3 10 10 10 2 TPR/MLP1/MLP2-like protein RAG2 PF03089.14 CRG85770.1 - 0.027 13.5 0.0 0.95 8.4 0.0 3.2 5 0 0 5 5 5 0 Recombination activating protein 2 Raptor_N PF14538.6 CRG85771.1 - 1e-64 216.9 0.0 1.8e-64 216.1 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 CRG85771.1 - 8.6e-06 26.4 11.6 0.51 11.3 0.0 6.4 5 1 0 5 5 5 1 WD domain, G-beta repeat HEAT PF02985.22 CRG85771.1 - 0.012 15.8 1.1 13 6.4 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat BBS2_Mid PF14783.6 CRG85771.1 - 0.015 15.4 0.8 0.92 9.6 0.1 2.8 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region RNase_T PF00929.24 CRG85771.1 - 0.095 13.2 0.3 1.2 9.7 0.0 2.5 3 0 0 3 3 3 0 Exonuclease Atx10homo_assoc PF09759.9 CRG85771.1 - 0.17 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain Rotamase_3 PF13616.6 CRG85773.1 - 3.6e-13 50.1 1.3 7.1e-13 49.1 0.0 2.1 3 0 0 3 3 3 1 PPIC-type PPIASE domain Rotamase PF00639.21 CRG85773.1 - 5.9e-13 49.6 0.0 6.2e-12 46.3 0.0 2.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain 2OG-FeII_Oxy_2 PF13532.6 CRG85774.1 - 3.9e-14 53.3 0.0 4.6e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Steroid_dh PF02544.16 CRG85775.1 - 4.9e-09 36.3 0.7 4.9e-09 36.3 0.7 1.9 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Ribosomal_L7Ae PF01248.26 CRG85776.1 - 2.9e-25 87.8 1.0 6.2e-25 86.8 1.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ank_2 PF12796.7 CRG85776.1 - 1.3e-20 73.8 0.1 2.4e-10 40.8 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG85776.1 - 6.8e-18 64.5 0.4 1.2e-07 31.9 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG85776.1 - 2.8e-15 56.5 0.0 1.5e-07 31.8 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CRG85776.1 - 1.4e-13 50.6 0.2 0.002 18.5 0.0 4.6 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 CRG85776.1 - 1.6e-10 40.3 1.0 0.024 15.1 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Vac_ImportDeg PF09783.9 CRG85777.1 - 1.4e-40 138.8 0.1 4.1e-40 137.2 0.0 1.7 2 0 0 2 2 2 1 Vacuolar import and degradation protein LAT PF15234.6 CRG85777.1 - 0.074 12.8 0.8 0.23 11.2 0.6 1.9 2 0 0 2 2 2 0 Linker for activation of T-cells DUF3915 PF13054.6 CRG85777.1 - 0.99 9.4 3.5 2 8.4 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) IU_nuc_hydro PF01156.19 CRG85778.1 - 5.4e-82 275.8 0.0 6.3e-82 275.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase HAMP_N3 PF18575.1 CRG85778.1 - 0.096 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 HAMP N-terminal domain 3 PXA PF02194.15 CRG85780.1 - 6.9e-42 143.5 0.1 1.7e-41 142.2 0.1 1.7 1 0 0 1 1 1 1 PXA domain HTH_Tnp_Tc5 PF03221.16 CRG85781.1 - 4.2e-15 55.5 0.1 9.9e-15 54.3 0.0 1.7 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 CRG85781.1 - 0.0001 21.9 0.6 0.12 12.1 0.1 3.0 3 0 0 3 3 3 2 CENP-B N-terminal DNA-binding domain MMR_HSR1_Xtn PF16897.5 CRG85782.1 - 1.5e-39 134.3 0.2 1.2e-38 131.4 0.0 2.3 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CRG85782.1 - 1.8e-22 79.1 0.1 4.7e-22 77.8 0.1 1.8 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 CRG85782.1 - 1.8e-21 76.3 0.1 5e-21 74.9 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG85782.1 - 1e-09 38.1 0.0 4.4e-09 36.1 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CRG85782.1 - 0.00033 20.8 0.1 0.07 13.2 0.0 2.4 1 1 1 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 CRG85782.1 - 0.00064 19.3 0.0 7.4 6.1 0.0 3.9 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 CRG85782.1 - 0.0076 15.3 0.1 0.019 13.9 0.1 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 CRG85782.1 - 0.022 14.1 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 AIG1 family Arf PF00025.21 CRG85782.1 - 0.1 12.1 0.1 3 7.2 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 CRG85782.1 - 0.25 11.2 2.4 4.5 7.2 0.0 3.1 4 0 0 4 4 4 0 RsgA GTPase Glyco_transf_8 PF01501.20 CRG85783.1 - 5.3e-26 91.7 0.1 5.5e-25 88.4 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Nucleotid_trans PF03407.16 CRG85783.1 - 0.094 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Prok-E2_E PF14462.6 CRG85783.1 - 0.32 10.8 3.7 0.68 9.7 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic E2 family E Abhydrolase_6 PF12697.7 CRG85784.1 - 8.4e-14 52.7 0.0 2.5e-13 51.2 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG85784.1 - 2e-12 47.3 0.1 2.9e-11 43.5 0.1 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG85784.1 - 7.5e-05 22.1 0.0 0.00011 21.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 CRG85784.1 - 0.046 14.1 0.1 0.092 13.1 0.1 1.5 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Ser_hydrolase PF06821.13 CRG85784.1 - 0.053 13.4 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_2 PF02230.16 CRG85784.1 - 0.12 12.2 0.0 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Glyco_transf_90 PF05686.12 CRG85785.1 - 7.9e-16 57.9 8.5 2.2e-13 49.9 5.5 2.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 Ferric_reduct PF01794.19 CRG85785.1 - 1.9e-09 37.7 3.1 7.4e-09 35.8 3.4 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component HEAT PF02985.22 CRG85787.1 - 1.3e-41 137.0 9.8 0.015 15.5 0.1 13.4 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 CRG85787.1 - 3.7e-36 123.4 5.6 6.3e-11 42.5 0.0 8.3 4 2 4 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 CRG85787.1 - 7e-17 61.6 1.4 0.036 14.6 0.0 8.4 7 2 2 9 9 9 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CRG85787.1 - 1e-12 48.4 4.5 0.00067 20.2 0.2 7.7 5 2 4 9 9 9 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CRG85787.1 - 1.4e-10 41.4 12.7 0.0027 17.8 0.1 5.8 6 1 1 7 7 7 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CRG85787.1 - 3.5e-10 39.1 4.6 3.5e-05 22.6 0.1 3.8 4 0 0 4 4 4 3 Adaptin N terminal region RTP1_C1 PF10363.9 CRG85787.1 - 1.3e-06 28.5 3.5 1.4 9.2 0.1 5.1 3 1 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 CRG85787.1 - 0.00053 19.6 1.3 6 6.4 0.1 4.4 3 2 2 5 5 5 2 CLASP N terminal IFRD PF05004.13 CRG85787.1 - 0.016 14.3 0.3 0.78 8.8 0.0 3.5 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) Arm PF00514.23 CRG85787.1 - 0.019 15.0 8.4 4.6 7.4 0.0 5.9 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat DOCK_N PF16172.5 CRG85787.1 - 0.073 12.0 0.4 1.1 8.0 0.0 2.5 2 1 0 2 2 2 0 DOCK N-terminus Ecm29 PF13001.7 CRG85787.1 - 0.099 11.3 1.6 4.9 5.7 0.2 3.4 2 1 0 3 3 3 0 Proteasome stabiliser Proteasom_PSMB PF10508.9 CRG85787.1 - 0.12 10.8 5.7 0.43 9.0 0.0 2.9 2 1 1 3 3 3 0 Proteasome non-ATPase 26S subunit DRIM PF07539.12 CRG85787.1 - 1.2 7.4 5.6 2 6.6 0.5 3.1 2 1 0 4 4 4 0 Down-regulated in metastasis tRNA_synthFbeta PF17759.1 CRG85788.1 - 4.1e-50 170.2 0.0 6e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 CRG85788.1 - 8.9e-33 112.4 0.3 3e-31 107.5 0.1 2.4 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 CRG85788.1 - 1.1e-25 90.3 0.0 2.6e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 CRG85788.1 - 2.6e-20 72.5 0.0 2.9e-17 62.7 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain Ribosomal_S3_C PF00189.20 CRG85789.1 - 1.2e-24 86.7 0.2 5.7e-24 84.4 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 CRG85789.1 - 7e-12 45.0 0.1 1.2e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 CRG85789.1 - 0.1 13.1 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 CRG85789.1 - 0.15 11.9 0.2 0.34 10.7 0.0 1.6 2 0 0 2 2 2 0 Coilin N-terminus Myotub-related PF06602.14 CRG85790.1 - 2.3e-151 503.7 0.0 3.3e-151 503.2 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain GRAM PF02893.20 CRG85790.1 - 0.049 13.5 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 GRAM domain Y_phosphatase3 PF13350.6 CRG85790.1 - 0.16 11.9 0.5 0.54 10.2 0.0 2.1 3 0 0 3 3 3 0 Tyrosine phosphatase family Cellulase PF00150.18 CRG85791.1 - 4e-14 52.7 0.3 5.9e-14 52.2 0.3 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SLS PF14611.6 CRG85793.1 - 4.5e-20 72.5 0.0 8.6e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator A_deamin PF02137.18 CRG85793.1 - 6.8e-18 65.2 0.0 1.7e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain SF3b10 PF07189.11 CRG85794.1 - 5.2e-35 119.4 0.0 5.7e-35 119.3 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) DUF3074 PF11274.8 CRG85795.1 - 3e-55 187.0 1.3 3.8e-55 186.7 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) DUF812 PF05667.11 CRG85795.1 - 2.8e-05 23.2 13.5 4.6e-05 22.5 13.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) START PF01852.19 CRG85795.1 - 0.00045 19.7 0.0 0.096 12.1 0.0 2.4 2 0 0 2 2 2 1 START domain HALZ PF02183.18 CRG85795.1 - 0.029 14.6 1.0 0.029 14.6 1.0 2.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper APG6_N PF17675.1 CRG85795.1 - 0.052 14.1 28.9 1.5 9.3 2.1 3.6 1 1 2 3 3 3 0 Apg6 coiled-coil region DivIC PF04977.15 CRG85795.1 - 0.54 10.1 17.3 0.21 11.4 3.4 3.6 2 1 1 3 3 3 0 Septum formation initiator DUF724 PF05266.14 CRG85795.1 - 0.99 9.2 14.9 6.9 6.5 10.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF5320 PF17253.2 CRG85795.1 - 1.3 10.1 7.6 20 6.4 0.1 3.1 2 1 0 2 2 2 0 Family of unknown function (DUF5320) DUF3829 PF12889.7 CRG85795.1 - 2 7.8 12.9 2 7.8 9.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3829) DUF4140 PF13600.6 CRG85795.1 - 2 8.9 19.3 0.4 11.1 0.3 3.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Seryl_tRNA_N PF02403.22 CRG85795.1 - 2.2 8.5 17.6 47 4.3 11.7 3.5 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 CRG85795.1 - 4.6 7.7 9.3 6.7 7.2 1.4 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 CRG85795.1 - 6.6 7.1 20.9 0.44 11.0 15.0 2.0 2 0 0 2 2 2 0 Fez1 FapA PF03961.13 CRG85795.1 - 7.3 5.1 18.8 5.7 5.4 11.5 2.2 1 1 0 2 2 2 0 Flagellar Assembly Protein A Putative_PNPOx PF01243.20 CRG85797.1 - 0.0008 19.5 0.0 0.0019 18.3 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Sugar_tr PF00083.24 CRG85798.1 - 2e-100 336.8 28.9 2.3e-100 336.6 28.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG85798.1 - 1.1e-25 90.4 36.9 3.7e-19 68.9 13.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2313 PF10076.9 CRG85799.1 - 0.17 11.8 1.1 11 5.8 0.1 2.2 1 1 1 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2313) Tektin PF03148.14 CRG85800.1 - 0.0017 17.2 3.6 0.0021 16.9 3.6 1.0 1 0 0 1 1 1 1 Tektin family Seryl_tRNA_N PF02403.22 CRG85800.1 - 0.003 17.8 6.4 0.004 17.4 6.4 1.1 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain T3SSipB PF16535.5 CRG85800.1 - 0.0086 16.6 2.1 0.011 16.3 2.1 1.1 1 0 0 1 1 1 1 Type III cell invasion protein SipB DUF4094 PF13334.6 CRG85800.1 - 0.013 15.9 1.2 0.019 15.4 1.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) Peptidase_M55 PF04951.13 CRG85800.1 - 0.028 13.8 0.7 0.033 13.6 0.7 1.1 1 0 0 1 1 1 0 D-aminopeptidase Phg_2220_C PF09524.10 CRG85800.1 - 0.032 14.3 1.6 0.048 13.7 1.6 1.2 1 0 0 1 1 1 0 Conserved phage C-terminus (Phg_2220_C) RNA_pol_Rpb1_2 PF00623.20 CRG85800.1 - 0.042 14.1 0.3 0.051 13.8 0.3 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 2 DUF4250 PF14056.6 CRG85800.1 - 0.071 13.1 0.4 0.75 9.8 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4250) Lipase_GDSL_3 PF14606.6 CRG85800.1 - 0.12 12.5 0.8 0.15 12.2 0.8 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family TMF_DNA_bd PF12329.8 CRG85800.1 - 1.1 9.4 10.3 1.2 9.2 2.2 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding NT-C2 PF10358.9 CRG85801.1 - 3.9e-36 123.9 0.0 5.4e-36 123.5 0.0 1.2 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins ERG4_ERG24 PF01222.17 CRG85802.1 - 6.8e-149 496.3 5.4 8.2e-149 496.0 5.4 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 CRG85802.1 - 0.0014 18.2 0.8 0.0031 17.1 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) POTRA_2 PF08479.11 CRG85802.1 - 0.14 12.0 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 POTRA domain, ShlB-type Man-6-P_recep PF02157.15 CRG85803.1 - 1e-14 54.3 0.1 2.5e-14 53.0 0.0 1.6 2 0 0 2 2 2 1 Mannose-6-phosphate receptor ATG27 PF09451.10 CRG85803.1 - 3.5e-10 40.2 0.0 9e-10 38.8 0.0 1.8 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 CRG85803.1 - 2.2e-07 31.0 0.5 0.00022 21.3 0.1 2.5 2 1 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Fungal_trans PF04082.18 CRG85806.1 - 8.8e-27 93.8 0.0 1.6e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85806.1 - 4e-09 36.4 12.3 6.5e-09 35.8 12.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 CRG85807.1 - 6.9e-29 100.7 2.9 1.9e-28 99.3 2.9 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG85807.1 - 1.8e-17 63.7 1.9 2.6e-17 63.2 1.9 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG85807.1 - 9.7e-11 41.9 0.5 1.4e-10 41.4 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG85807.1 - 9.5e-07 28.5 0.2 1.2e-06 28.1 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG85807.1 - 4.9e-06 26.2 0.1 6.6e-06 25.7 0.1 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CRG85807.1 - 0.014 14.6 0.2 0.018 14.2 0.2 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein EBP PF05241.12 CRG85808.1 - 0.54 9.7 9.6 0.093 12.2 4.2 2.2 1 1 1 3 3 3 0 Emopamil binding protein bZIP_1 PF00170.21 CRG85809.1 - 8.6e-05 22.6 12.7 0.00014 21.9 7.1 2.2 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 CRG85809.1 - 1.2 9.3 11.2 0.78 9.9 2.5 2.4 1 1 1 2 2 2 0 Basic region leucine zipper Glyco_hydro_3_C PF01915.22 CRG85810.1 - 5.1e-53 180.1 0.0 1e-52 179.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG85810.1 - 1.3e-41 143.1 0.0 2.2e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG85810.1 - 2.8e-16 59.4 0.4 5.2e-16 58.5 0.4 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain MFS_1 PF07690.16 CRG85811.1 - 4.3e-29 101.6 48.5 4.3e-29 101.6 48.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG85811.1 - 0.024 14.0 37.3 0.032 13.5 37.3 1.1 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Scs3p PF10261.9 CRG85812.1 - 7.4e-72 241.8 1.6 1.1e-71 241.3 1.6 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM DUF2628 PF10947.8 CRG85812.1 - 0.24 11.8 0.2 0.24 11.8 0.2 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2628) Nop52 PF05997.12 CRG85813.1 - 0.018 14.9 0.2 4.1 7.1 0.2 2.4 2 1 0 2 2 2 0 Nucleolar protein,Nop52 Phage_ABA_S PF18066.1 CRG85813.1 - 0.094 13.4 0.4 4.7 8.0 0.0 2.4 1 1 1 2 2 2 0 Phage ABA sandwich domain DDE_Tnp_1_3 PF13612.6 CRG85813.1 - 0.17 11.9 0.0 0.44 10.6 0.0 1.6 2 0 0 2 2 2 0 Transposase DDE domain Erythro_esteras PF05139.14 CRG85814.1 - 1.7e-126 422.7 0.9 2e-126 422.5 0.9 1.0 1 0 0 1 1 1 1 Erythromycin esterase Cofac_haem_bdg PF04187.13 CRG85814.1 - 0.00091 19.3 0.1 0.22 11.5 0.0 2.2 2 0 0 2 2 2 2 Haem-binding uptake, Tiki superfamily, ChaN bact-PGI_C PF10432.9 CRG85814.1 - 0.0034 17.4 0.0 1.6 8.8 0.0 2.7 3 0 0 3 3 3 2 Bacterial phospho-glucose isomerase C-terminal SIS domain Ank_2 PF12796.7 CRG85815.1 - 1.7e-19 70.2 6.0 1.1e-05 26.0 0.1 5.3 3 1 1 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG85815.1 - 9.1e-14 50.2 4.9 1.3 9.8 0.1 8.6 9 0 0 9 9 9 4 Ankyrin repeat Ank_4 PF13637.6 CRG85815.1 - 6.9e-12 45.6 7.6 0.044 14.4 0.0 7.6 5 2 3 8 8 8 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG85815.1 - 4e-11 42.9 10.1 0.00035 20.8 0.7 6.6 6 1 1 7 7 7 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG85815.1 - 1e-09 38.4 8.5 0.2 12.1 0.1 6.9 7 0 0 7 7 7 4 Ankyrin repeat HTH_16 PF12645.7 CRG85815.1 - 0.015 15.3 0.0 0.045 13.8 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2280 PF10045.9 CRG85815.1 - 0.032 14.5 0.0 0.082 13.2 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) DUF3535 PF12054.8 CRG85817.1 - 1.7e-128 429.5 0.0 2.4e-127 425.8 0.0 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 CRG85817.1 - 7.5e-62 209.1 0.0 1.8e-61 207.8 0.0 1.5 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG85817.1 - 1.1e-19 70.8 0.0 2.8e-19 69.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 CRG85817.1 - 1.1e-14 53.2 17.0 0.13 12.6 0.0 11.2 12 0 0 12 12 12 4 HEAT repeat HEAT_2 PF13646.6 CRG85817.1 - 3.9e-08 33.6 8.3 0.0018 18.6 0.2 6.4 5 2 2 7 7 7 2 HEAT repeats Vac14_Fab1_bd PF12755.7 CRG85817.1 - 4.6e-07 30.4 0.0 0.072 13.7 0.0 4.0 3 1 0 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CRG85817.1 - 0.00025 21.1 0.2 0.3 11.1 0.0 4.4 5 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 TAF6_C PF07571.13 CRG85817.1 - 0.0066 16.8 0.0 8.8 6.7 0.0 4.4 4 0 0 4 4 4 1 TAF6 C-terminal HEAT repeat domain HEAT_EZ PF13513.6 CRG85817.1 - 0.033 14.7 11.5 29 5.3 0.0 7.3 8 1 0 8 8 8 0 HEAT-like repeat ERCC3_RAD25_C PF16203.5 CRG85817.1 - 0.076 12.2 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CLASP_N PF12348.8 CRG85817.1 - 0.19 11.2 0.5 8.2 5.9 0.0 3.1 2 2 1 3 3 3 0 CLASP N terminal Ndufs5 PF10200.9 CRG85818.1 - 2.2e-05 24.6 0.0 3.2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa CHCH PF06747.13 CRG85818.1 - 0.037 14.2 0.2 0.056 13.6 0.2 1.3 1 0 0 1 1 1 0 CHCH domain DUF3128 PF11326.8 CRG85818.1 - 0.14 12.6 1.2 0.83 10.1 1.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) Defensin_5 PF18251.1 CRG85818.1 - 0.15 12.1 0.2 0.28 11.3 0.2 1.4 1 0 0 1 1 1 0 Fungal defensin Copsin Sec39 PF08314.11 CRG85819.1 - 1.7e-247 823.7 0.3 2e-247 823.4 0.3 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Pkinase PF00069.25 CRG85820.1 - 1.9e-58 198.0 0.0 2.3e-58 197.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85820.1 - 2.6e-32 112.1 0.0 3.5e-32 111.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG85820.1 - 2e-07 30.6 0.0 3.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CRG85820.1 - 7.1e-05 21.8 0.0 0.00012 21.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CRG85820.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CRG85820.1 - 0.16 11.0 0.0 0.24 10.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 DUF5566 PF17721.1 CRG85822.1 - 0.015 15.6 9.5 0.026 14.8 9.5 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5566) TPR_1 PF00515.28 CRG85824.1 - 2.4e-44 147.4 19.1 9.7e-09 34.7 0.4 7.7 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 CRG85824.1 - 6.6e-39 128.9 21.6 1.7e-06 27.7 0.4 7.9 8 0 0 8 8 7 7 Tetratricopeptide repeat DnaJ PF00226.31 CRG85824.1 - 5.5e-25 87.3 2.2 5.5e-25 87.3 2.2 3.3 4 0 0 4 4 3 1 DnaJ domain TPR_19 PF14559.6 CRG85824.1 - 1.5e-24 86.3 19.2 1.2e-06 28.9 0.5 5.9 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 CRG85824.1 - 2.9e-24 85.4 17.7 2.5e-08 34.4 0.1 5.7 4 2 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CRG85824.1 - 1.3e-23 81.2 18.4 0.00015 21.7 0.1 8.3 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 CRG85824.1 - 1.7e-23 82.0 18.7 1e-09 37.9 0.2 6.9 4 2 2 6 6 6 6 TPR repeat TPR_14 PF13428.6 CRG85824.1 - 3.8e-21 74.0 14.4 0.00011 22.7 0.1 7.7 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 CRG85824.1 - 6.4e-20 70.1 15.7 4e-05 23.7 0.0 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 CRG85824.1 - 8.7e-18 63.0 13.7 0.013 15.5 0.2 8.0 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 CRG85824.1 - 3.2e-17 62.6 17.8 0.00057 20.1 1.6 6.6 3 2 1 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 CRG85824.1 - 6.4e-13 48.4 15.2 0.00013 22.3 0.2 8.3 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG85824.1 - 9.2e-12 44.9 8.7 0.0021 18.2 0.2 4.7 3 2 2 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG85824.1 - 9.8e-12 44.9 7.0 0.00086 19.5 0.1 4.2 2 2 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 CRG85824.1 - 1.6e-11 44.1 9.2 0.00015 21.7 0.2 5.2 4 1 1 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 CRG85824.1 - 2.2e-11 43.5 9.8 0.00066 19.0 0.3 4.8 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 CRG85824.1 - 7.2e-06 25.7 26.6 1.5 8.8 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 CRG85824.1 - 8.5e-06 25.1 8.5 0.14 11.7 1.0 5.7 5 0 0 5 5 5 1 SHNi-TPR ChAPs PF09295.10 CRG85824.1 - 0.0004 19.5 0.7 0.068 12.2 0.1 2.8 2 1 1 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 CRG85824.1 - 0.00079 19.7 10.5 1.1 9.6 0.1 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 CRG85824.1 - 0.0013 19.2 4.9 12 6.3 0.0 4.7 2 2 1 3 3 3 0 Alkyl sulfatase dimerisation BTAD PF03704.17 CRG85824.1 - 0.0016 18.9 11.0 0.22 12.0 0.9 4.1 2 2 0 3 3 3 2 Bacterial transcriptional activator domain DUF627 PF04781.12 CRG85824.1 - 0.0097 15.9 1.8 0.25 11.4 0.4 3.4 3 1 0 3 3 3 1 Protein of unknown function (DUF627) TPR_4 PF07721.14 CRG85824.1 - 0.017 15.7 15.3 0.33 11.7 0.4 5.2 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG85824.1 - 0.022 14.2 5.1 2.4 7.5 0.6 3.5 2 2 0 3 3 3 0 MalT-like TPR region MIT PF04212.18 CRG85824.1 - 0.039 14.0 16.3 0.35 11.0 0.1 5.8 5 1 1 6 6 6 0 MIT (microtubule interacting and transport) domain Coatomer_E PF04733.14 CRG85824.1 - 0.064 12.7 1.5 3.8 6.8 0.1 2.8 2 1 0 2 2 2 0 Coatomer epsilon subunit Vta1_C PF18097.1 CRG85824.1 - 0.55 10.0 2.9 1.6 8.5 0.2 3.3 4 0 0 4 4 3 0 Vta1 C-terminal domain DUF5588 PF17826.1 CRG85824.1 - 0.98 8.2 9.3 1.2 8.0 0.0 3.4 3 1 1 4 4 3 0 Family of unknown function (DUF5588) Sugar_tr PF00083.24 CRG85825.1 - 1.1e-85 288.2 30.9 1.3e-85 288.0 30.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG85825.1 - 4.8e-15 55.3 38.0 1.9e-11 43.5 14.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PBP1_TM PF14812.6 CRG85826.1 - 0.4 11.1 0.0 0.4 11.1 0.0 2.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal HC2 PF07382.11 CRG85827.1 - 0.39 10.8 54.3 0.76 9.8 54.3 1.5 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Pkinase PF00069.25 CRG85828.1 - 4.6e-40 137.7 0.0 6.5e-40 137.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85828.1 - 3e-28 98.8 0.0 4.7e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG85828.1 - 0.006 15.9 0.0 0.0091 15.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CRG85828.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Med10 PF09748.9 CRG85829.1 - 1.1e-43 148.1 0.0 1.3e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 CRG85829.1 - 0.093 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) Peptidase_M28 PF04389.17 CRG85833.1 - 4.4e-34 117.9 0.0 7.2e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CRG85833.1 - 0.049 13.3 0.0 0.092 12.4 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 ATP-synt_8 PF00895.20 CRG85833.1 - 0.72 10.4 0.0 0.72 10.4 0.0 4.4 5 0 0 5 5 5 0 ATP synthase protein 8 LRR_6 PF13516.6 CRG85834.1 - 3e-16 58.0 22.4 0.5 10.6 0.1 12.9 13 1 0 13 13 13 4 Leucine Rich repeat LRR_4 PF12799.7 CRG85834.1 - 5e-11 42.6 18.6 0.1 13.0 0.1 7.9 4 3 4 9 9 9 8 Leucine Rich repeats (2 copies) F-box-like PF12937.7 CRG85834.1 - 5.7e-11 42.1 1.4 1.2e-10 41.1 0.2 2.1 2 0 0 2 2 2 1 F-box-like DUF1699 PF08004.11 CRG85834.1 - 0.00027 20.6 0.7 0.27 10.9 0.0 3.7 3 1 0 3 3 3 1 Protein of unknown function (DUF1699) Recep_L_domain PF01030.24 CRG85834.1 - 0.00028 21.0 0.7 0.3 11.2 0.0 3.9 1 1 2 4 4 4 1 Receptor L domain F-box PF00646.33 CRG85834.1 - 0.021 14.7 0.2 0.021 14.7 0.2 2.8 3 0 0 3 3 3 0 F-box domain Preseq_ALAS PF09029.10 CRG85834.1 - 0.048 14.1 4.5 0.66 10.5 0.1 3.8 3 1 1 4 4 4 0 5-aminolevulinate synthase presequence LRR_8 PF13855.6 CRG85834.1 - 2 8.3 15.3 2.1 8.2 0.0 6.3 4 1 4 8 8 8 0 Leucine rich repeat AMP-binding_C PF13193.6 CRG85835.1 - 1.6e-17 64.3 0.4 2.1e-17 63.9 0.4 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 CRG85837.1 - 2.4e-73 247.2 0.0 2.8e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme LysR_substrate PF03466.20 CRG85837.1 - 0.094 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 LysR substrate binding domain Ribosomal_L13 PF00572.18 CRG85838.1 - 8.5e-11 42.2 0.3 1.1e-08 35.3 0.0 2.7 2 1 0 2 2 2 1 Ribosomal protein L13 Metallophos PF00149.28 CRG85839.1 - 1.8e-08 35.1 0.2 2.4e-08 34.7 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_3 PF14582.6 CRG85839.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily DnaJ PF00226.31 CRG85840.1 - 4.1e-20 71.7 0.7 1e-19 70.4 0.7 1.7 1 0 0 1 1 1 1 DnaJ domain DUF883 PF05957.13 CRG85840.1 - 8.9 7.0 7.9 32 5.2 1.4 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Adaptin_N PF01602.20 CRG85843.1 - 5.3e-142 474.0 1.4 6.2e-142 473.8 1.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 CRG85843.1 - 5.5e-18 65.3 0.0 1.6e-17 63.8 0.0 1.8 2 0 0 2 2 2 1 Adaptin C-terminal domain HEAT_2 PF13646.6 CRG85843.1 - 7.3e-07 29.5 2.7 0.02 15.3 0.0 4.3 5 0 0 5 5 5 2 HEAT repeats Cnd1 PF12717.7 CRG85843.1 - 2.2e-06 27.8 12.0 0.00035 20.7 0.1 4.8 3 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 CRG85843.1 - 0.015 15.4 0.2 1.1e+02 3.1 0.1 5.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CRG85843.1 - 0.023 14.9 2.2 21 5.7 0.1 4.7 4 0 0 4 4 4 0 HEAT repeat MBOAT PF03062.19 CRG85844.1 - 3.2e-39 135.3 16.2 3.2e-39 135.3 16.2 2.1 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family Pex14_N PF04695.13 CRG85844.1 - 0.019 15.6 0.0 2 9.0 0.0 2.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EamA PF00892.20 CRG85845.1 - 2.6e-10 40.6 28.0 1.1e-05 25.6 6.1 2.5 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 CRG85845.1 - 3.2e-09 36.4 0.7 7.9e-09 35.1 0.7 1.7 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 CRG85845.1 - 0.00013 21.5 0.8 0.00013 21.5 0.8 2.5 2 1 0 2 2 2 1 Triose-phosphate Transporter family UAA PF08449.11 CRG85845.1 - 0.0015 17.8 9.0 0.0015 17.8 9.0 1.7 2 0 0 2 2 2 1 UAA transporter family WBS28 PF15164.6 CRG85845.1 - 0.29 10.4 4.9 0.62 9.3 4.9 1.5 1 0 0 1 1 1 0 Williams-Beuren syndrome chromosomal region 28 protein homologue CRT-like PF08627.10 CRG85845.1 - 1.3 7.9 13.4 0.53 9.2 5.6 3.2 2 1 0 3 3 3 0 CRT-like, chloroquine-resistance transporter-like Trp_oprn_chp PF09534.10 CRG85845.1 - 1.5 8.6 10.2 8 6.2 6.7 2.9 1 1 2 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DIOX_N PF14226.6 CRG85847.1 - 3.9e-28 98.6 0.0 5.8e-28 98.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG85847.1 - 3.1e-21 75.7 0.0 5.4e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Kelch_1 PF01344.25 CRG85847.1 - 0.028 14.0 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Epimerase PF01370.21 CRG85848.1 - 1.6e-16 60.5 0.0 2.3e-16 60.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG85848.1 - 5.7e-11 41.9 0.0 7.7e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG85848.1 - 2.2e-07 30.6 0.0 4e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG85848.1 - 1.4e-06 27.7 0.0 0.0042 16.3 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CRG85848.1 - 6.7e-06 26.1 0.0 1.4e-05 25.0 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding KR PF08659.10 CRG85848.1 - 4.3e-05 23.5 0.0 6.6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CRG85848.1 - 0.0018 17.9 0.0 0.04 13.5 0.0 2.1 2 0 0 2 2 2 1 NmrA-like family F420_oxidored PF03807.17 CRG85848.1 - 0.0036 17.9 0.0 0.0091 16.6 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 CRG85848.1 - 0.008 15.6 0.0 0.016 14.7 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 CRG85848.1 - 0.085 12.0 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Med15_fungi PF05397.12 CRG85849.1 - 1.1e-18 67.5 0.2 1.1e-18 67.5 0.2 6.0 7 1 1 8 8 8 1 Mediator complex subunit 15 KIX_2 PF16987.5 CRG85849.1 - 5.3e-07 29.5 2.1 1.6e-05 24.8 2.1 3.5 1 1 0 1 1 1 1 KIX domain LMBR1 PF04791.16 CRG85850.1 - 1e-127 427.2 0.4 1.2e-127 427.0 0.4 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein FUSC PF04632.12 CRG85850.1 - 0.0027 16.3 2.4 0.0027 16.3 2.4 2.4 2 0 0 2 2 2 1 Fusaric acid resistance protein family PspA_IM30 PF04012.12 CRG85850.1 - 0.028 14.0 1.9 0.68 9.5 0.0 2.1 2 0 0 2 2 2 0 PspA/IM30 family GAS PF13851.6 CRG85850.1 - 0.068 12.5 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FliJ PF02050.16 CRG85850.1 - 0.11 12.7 2.3 10 6.4 0.2 2.2 2 0 0 2 2 2 0 Flagellar FliJ protein Apolipoprotein PF01442.18 CRG85850.1 - 1 9.2 7.0 0.25 11.2 2.4 1.9 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DHR10 PF18595.1 CRG85850.1 - 1.4 9.0 5.7 1.5 8.9 1.3 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain BAG PF02179.16 CRG85852.1 - 6.4e-14 52.2 0.1 1.9e-13 50.6 0.1 1.9 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 CRG85852.1 - 0.00044 19.9 0.1 0.00081 19.1 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family FAM176 PF14851.6 CRG85852.1 - 0.00085 19.0 2.2 0.013 15.2 0.0 2.4 2 0 0 2 2 2 1 FAM176 family NicO PF03824.16 CRG85852.1 - 0.072 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF2407 PF10302.9 CRG85852.1 - 0.13 12.9 0.6 0.35 11.4 0.6 1.8 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain GREB1 PF15782.5 CRG85852.1 - 0.61 7.1 2.9 0.9 6.6 2.9 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Dynamin_N PF00350.23 CRG85853.1 - 6.1e-31 107.7 0.0 2.6e-30 105.7 0.0 2.2 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CRG85853.1 - 9.7e-20 70.9 0.2 1.1e-18 67.5 0.0 2.5 2 1 1 3 3 3 1 Dynamin central region GED PF02212.18 CRG85853.1 - 1.5e-06 28.3 1.0 3.9e-06 26.9 0.1 2.3 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CRG85853.1 - 0.00058 19.9 0.1 0.0047 17.0 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG85853.1 - 0.03 14.7 0.2 0.17 12.3 0.0 2.3 3 0 0 3 3 3 0 AAA ATPase domain AAA_21 PF13304.6 CRG85853.1 - 0.031 14.1 0.5 0.86 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CRG85853.1 - 0.062 13.0 0.7 0.52 10.0 0.0 2.5 2 1 1 3 3 3 0 AAA ATPase domain Ras PF00071.22 CRG85853.1 - 0.16 11.6 0.3 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 Ras family T2SSG PF08334.11 CRG85854.1 - 0.19 11.8 0.1 0.31 11.1 0.1 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein G Papilloma_E5 PF03025.14 CRG85854.1 - 0.56 10.4 6.6 8.1 6.7 2.3 2.2 2 0 0 2 2 2 0 Papillomavirus E5 O-antigen_lig PF13425.6 CRG85854.1 - 1.4 7.6 7.3 2.7 6.7 7.3 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein B277 PF17623.2 CRG85854.1 - 5.1 6.1 7.7 3.1 6.8 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function HEPN_Apea PF18739.1 CRG85855.1 - 0.021 15.2 0.0 0.055 13.9 0.0 1.7 1 0 0 1 1 1 0 Apea-like HEPN Abi_2 PF07751.11 CRG85855.1 - 0.044 14.0 4.5 2.9 8.1 0.2 2.3 2 0 0 2 2 2 0 Abi-like protein Glutaredoxin PF00462.24 CRG85856.1 - 5.1e-18 65.1 0.0 8.7e-18 64.3 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 CRG85856.1 - 0.14 12.6 0.0 0.31 11.5 0.0 1.6 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Chalcone_2 PF16035.5 CRG85857.1 - 4.6e-77 258.4 0.0 8.2e-77 257.6 0.0 1.4 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 CRG85857.1 - 0.00014 22.0 0.8 0.00067 19.8 0.2 2.4 2 1 0 2 2 2 1 Chalcone isomerase-like CxC2 PF18803.1 CRG85857.1 - 0.12 12.5 1.7 0.2 11.8 0.2 1.9 2 0 0 2 2 2 0 CxC2 like cysteine cluster associated with KDZ transposases APH PF01636.23 CRG85858.1 - 0.0055 16.7 0.0 0.023 14.6 0.0 2.0 1 1 0 1 1 1 1 Phosphotransferase enzyme family MAGE PF01454.19 CRG85859.1 - 2.9e-60 203.6 0.0 4.6e-60 203.0 0.0 1.3 1 0 0 1 1 1 1 MAGE family Glyco_hydro_28 PF00295.17 CRG85859.1 - 9.1e-42 143.3 1.3 2.9e-41 141.6 1.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 DUF4834 PF16118.5 CRG85859.1 - 0.066 14.2 1.8 1 10.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PALP PF00291.25 CRG85860.1 - 2.7e-41 141.9 0.6 4.4e-41 141.2 0.6 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Bac_rhamnosid6H PF17389.2 CRG85860.1 - 1.4e-15 57.4 1.8 2.8e-14 53.1 1.2 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 CRG85860.1 - 6.7e-09 35.4 0.0 2.1e-08 33.8 0.0 1.9 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid PF05592.11 CRG85860.1 - 0.0049 16.8 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain ADH_zinc_N PF00107.26 CRG85860.1 - 0.037 14.0 0.2 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Ank_3 PF13606.6 CRG85863.1 - 2.3e-08 33.6 0.0 0.0066 16.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 CRG85863.1 - 4.5e-07 30.4 0.0 7.4e-07 29.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 CRG85863.1 - 8.3e-06 26.0 0.0 0.041 14.3 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CRG85863.1 - 2.4e-05 24.5 0.1 0.27 11.6 0.0 3.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG85863.1 - 0.0015 19.0 0.1 0.23 12.1 0.0 2.4 1 1 0 2 2 2 1 Ankyrin repeats (many copies) DUF1906 PF08924.11 CRG85863.1 - 0.069 13.3 0.0 0.089 12.9 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1906) TFIIS_C PF01096.18 CRG85864.1 - 1e-18 66.8 4.6 1e-18 66.8 4.6 3.0 2 1 0 2 2 2 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 CRG85864.1 - 1.3e-08 34.5 0.7 1.3e-08 34.5 0.7 2.6 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 CRG85864.1 - 0.00052 19.9 5.9 0.007 16.3 1.0 2.3 2 0 0 2 2 2 2 Transposase zinc-ribbon domain IBR PF01485.21 CRG85864.1 - 0.0062 16.7 8.1 0.5 10.6 0.2 2.5 1 1 1 2 2 2 2 IBR domain, a half RING-finger domain zf_Rg PF17915.1 CRG85864.1 - 0.027 13.9 0.5 0.027 13.9 0.5 2.0 3 0 0 3 3 3 0 Reverse gyrase zinc finger zf-TFIIB PF13453.6 CRG85864.1 - 0.043 13.1 0.7 0.043 13.1 0.7 2.7 3 0 0 3 3 3 0 Transcription factor zinc-finger Elf1 PF05129.13 CRG85864.1 - 0.049 13.7 3.9 0.5 10.4 0.1 2.3 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zf-H2C2_2 PF13465.6 CRG85864.1 - 0.073 13.5 9.6 4.1 8.0 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger double domain Nudix_N_2 PF14803.6 CRG85864.1 - 0.074 13.0 1.3 0.074 13.0 1.3 2.2 2 0 0 2 2 2 0 Nudix N-terminal C1_4 PF07975.12 CRG85864.1 - 0.13 12.5 8.9 7.9 6.8 0.8 3.3 2 2 1 3 3 3 0 TFIIH C1-like domain zinc_ribbon_4 PF13717.6 CRG85864.1 - 1.3 9.0 13.2 5.6 7.0 0.3 3.9 4 0 0 4 4 4 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 CRG85864.1 - 2.1 8.4 8.0 2.1 8.4 0.3 2.7 3 0 0 3 3 3 0 PhnA Zinc-Ribbon GTP_EFTU PF00009.27 CRG85865.1 - 1.4e-50 171.6 0.0 2e-50 171.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CRG85865.1 - 6.1e-41 139.2 0.0 4e-40 136.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CRG85865.1 - 7.9e-13 48.6 1.9 1.8e-12 47.5 1.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CRG85865.1 - 0.064 13.4 0.0 0.96 9.6 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 CRG85865.1 - 0.086 12.8 1.7 0.12 12.3 0.4 1.9 2 0 0 2 2 2 0 Elongation factor Tu domain 4 TPR_10 PF13374.6 CRG85866.1 - 5.2e-28 96.1 1.6 1.2e-09 37.7 0.1 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.6 CRG85866.1 - 9.5e-20 70.7 1.2 1.6e-10 41.1 0.1 3.9 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 CRG85866.1 - 8.5e-12 44.2 2.3 1.8e-05 24.4 0.1 5.0 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG85866.1 - 2.3e-11 43.5 0.1 0.28 12.1 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CRG85866.1 - 6.3e-10 38.4 8.0 6.2e-06 25.8 0.3 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG85866.1 - 8.2e-10 38.0 3.2 0.00045 20.1 0.1 5.3 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG85866.1 - 1.6e-07 31.0 7.9 0.00024 21.1 0.2 4.5 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG85866.1 - 2.5e-06 27.1 0.2 1.1e-05 25.0 0.2 1.8 1 1 0 2 2 2 1 MalT-like TPR region RPN6_N PF18055.1 CRG85866.1 - 0.00014 22.2 0.6 5.6 7.3 0.5 3.5 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_17 PF13431.6 CRG85866.1 - 0.00021 21.4 2.1 0.17 12.4 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 CRG85866.1 - 0.00035 21.1 0.5 0.15 12.7 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 CRG85866.1 - 0.00073 19.2 2.3 0.055 13.2 0.3 3.8 4 0 0 4 4 4 1 TPR repeat RPN7 PF10602.9 CRG85866.1 - 0.0032 17.2 0.0 3.1 7.5 0.0 3.5 3 1 0 4 4 4 1 26S proteasome subunit RPN7 Packaging_FI PF14000.6 CRG85866.1 - 0.0042 17.5 2.6 0.82 10.1 0.3 2.3 1 1 1 2 2 2 2 DNA packaging protein FI TPR_19 PF14559.6 CRG85866.1 - 0.02 15.4 1.4 3.2 8.3 0.6 3.6 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 CRG85866.1 - 0.021 14.6 0.2 0.044 13.5 0.1 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 CRG85866.1 - 0.059 14.0 2.2 23 5.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Vps4_C PF09336.10 CRG85866.1 - 0.07 13.1 0.0 4.2 7.4 0.0 2.3 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain MDMPI_N PF11716.8 CRG85866.1 - 0.083 13.6 0.1 5.6 7.6 0.0 2.1 1 1 1 2 2 2 0 Mycothiol maleylpyruvate isomerase N-terminal domain TPR_3 PF07720.12 CRG85866.1 - 0.094 12.7 1.2 12 6.0 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Halo_GVPC PF05465.13 CRG85866.1 - 0.1 12.9 0.3 7.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat LAP1C PF05609.12 CRG85867.1 - 1.9 7.5 18.2 2.6 7.0 18.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) MAS20 PF02064.15 CRG85867.1 - 2.6 8.1 8.8 31 4.7 9.6 2.2 2 0 0 2 2 2 0 MAS20 protein import receptor IBR PF01485.21 CRG85868.1 - 2.5e-10 40.4 13.5 2.6e-08 34.0 1.1 4.9 4 2 0 4 4 4 2 IBR domain, a half RING-finger domain SmAKAP PF15127.6 CRG85868.1 - 0.0057 17.8 0.4 0.016 16.3 0.4 1.8 1 0 0 1 1 1 1 Small membrane A-kinase anchor protein zf-B_box PF00643.24 CRG85868.1 - 0.87 9.8 24.4 0.59 10.3 2.2 4.7 4 0 0 4 4 4 0 B-box zinc finger Eapp_C PF10238.9 CRG85868.1 - 2.8 8.0 17.6 0.25 11.4 0.6 4.1 4 0 0 4 4 4 0 E2F-associated phosphoprotein zf-3CxxC PF13695.6 CRG85869.1 - 8.5e-24 83.9 1.6 1.3e-23 83.3 1.3 1.4 2 0 0 2 2 2 1 Zinc-binding domain zf-3CxxC_2 PF17180.4 CRG85869.1 - 0.15 12.8 4.8 0.77 10.5 0.8 2.7 2 1 0 2 2 2 0 Zinc-binding domain PCAF_N PF06466.11 CRG85869.1 - 0.75 9.3 4.1 0.16 11.5 0.7 1.5 2 0 0 2 2 2 0 PCAF (P300/CBP-associated factor) N-terminal domain TP_methylase PF00590.20 CRG85870.1 - 1.5e-16 61.0 0.0 1.5e-16 61.0 0.0 2.6 3 1 0 3 3 3 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Med31 PF05669.12 CRG85873.1 - 3.3e-30 104.0 0.0 4.2e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 SOH1 Pal1 PF08316.11 CRG85874.1 - 1.9e-45 155.0 3.0 2e-44 151.7 3.0 2.4 1 1 0 1 1 1 1 Pal1 cell morphology protein Mito_fiss_reg PF05308.11 CRG85875.1 - 0.011 15.9 0.2 0.032 14.3 0.2 1.8 1 0 0 1 1 1 0 Mitochondrial fission regulator BT1 PF03092.16 CRG85875.1 - 0.047 11.9 0.0 0.089 11.0 0.0 1.4 1 0 0 1 1 1 0 BT1 family DUF4611 PF15387.6 CRG85875.1 - 0.047 13.9 0.3 0.14 12.4 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) SPX PF03105.19 CRG85875.1 - 1.7 8.5 6.1 4.3 7.2 6.1 1.8 1 1 0 1 1 1 0 SPX domain PHD PF00628.29 CRG85876.1 - 1.3e-10 41.0 7.5 1.3e-10 41.0 7.5 2.0 2 0 0 2 2 2 1 PHD-finger APH PF01636.23 CRG85876.1 - 5.4e-06 26.5 0.5 6.7e-05 22.9 0.5 2.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Sec62 PF03839.16 CRG85877.1 - 3.7 7.0 5.9 6 6.3 5.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Hydin_ADK PF17213.3 CRG85877.1 - 3.7 7.8 6.6 5.3 7.3 5.7 1.7 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain PNP_UDP_1 PF01048.20 CRG85878.1 - 2e-17 63.2 0.0 3.6e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily Fungal_trans PF04082.18 CRG85879.1 - 5.1e-26 91.3 0.0 9.2e-26 90.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85879.1 - 2.5e-11 43.5 12.6 4.8e-11 42.6 12.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 2OG-FeII_Oxy_3 PF13640.6 CRG85880.1 - 2.1e-11 44.6 0.2 3.2e-11 44.0 0.2 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C2H2 PF00096.26 CRG85882.1 - 1.4e-06 28.4 18.0 1.7e-05 25.0 2.1 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG85882.1 - 1.2e-05 25.5 5.1 2.1e-05 24.7 2.2 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG85882.1 - 0.00012 22.6 1.2 0.00012 22.6 1.2 3.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG85882.1 - 0.00029 21.0 0.3 0.00099 19.3 0.3 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CRG85882.1 - 0.00083 19.3 0.9 0.0017 18.3 0.9 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CRG85882.1 - 0.077 13.3 2.6 0.2 12.0 2.6 1.8 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.7 CRG85882.1 - 0.1 13.0 0.3 0.29 11.6 0.3 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type MRFAP1 PF15155.6 CRG85882.1 - 0.15 12.6 1.1 1.3 9.6 0.0 2.6 2 1 0 2 2 2 0 MORF4 family-associated protein1 FOXP-CC PF16159.5 CRG85882.1 - 0.18 12.4 14.4 0.097 13.3 1.5 3.7 2 1 2 4 4 4 0 FOXP coiled-coil domain DUF4110 PF13422.6 CRG85882.1 - 0.52 10.4 4.7 0.35 11.0 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4110) Forkhead PF00250.18 CRG85883.1 - 7.5e-36 122.3 1.9 1.3e-35 121.5 1.9 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 CRG85883.1 - 1e-07 32.2 0.0 2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 FHA domain GFO_IDH_MocA PF01408.22 CRG85884.1 - 3.5e-08 34.3 0.1 9.3e-08 32.9 0.1 1.9 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold LigB PF02900.18 CRG85884.1 - 0.079 12.0 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase DHDPS PF00701.22 CRG85885.1 - 4.2e-33 114.3 0.0 1.4e-31 109.3 0.0 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family ADH_N PF08240.12 CRG85886.1 - 1.1e-25 89.6 7.8 1.9e-25 88.8 7.8 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG85886.1 - 5.3e-18 65.3 0.2 8.8e-17 61.3 0.1 2.4 1 1 1 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG85886.1 - 2.2e-05 23.9 0.4 4.3e-05 22.9 0.4 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 CRG85886.1 - 0.006 17.6 0.0 0.01 16.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CRG85886.1 - 0.04 13.2 0.3 0.26 10.6 0.0 2.3 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain WD40 PF00400.32 CRG85887.1 - 2.5e-28 97.7 11.6 6.7e-06 26.8 0.1 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat F-box-like PF12937.7 CRG85887.1 - 1.8e-09 37.3 0.1 4.4e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CRG85887.1 - 0.00013 22.2 0.1 0.76 10.1 0.0 4.4 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 CRG85887.1 - 0.0002 21.2 0.1 0.00047 20.0 0.1 1.7 1 0 0 1 1 1 1 F-box domain PQQ PF01011.21 CRG85887.1 - 0.0016 18.3 0.6 2.1 8.4 0.2 3.6 3 0 0 3 3 3 1 PQQ enzyme repeat EB1 PF03271.17 CRG85888.1 - 3.6e-17 62.3 0.9 8e-17 61.2 0.9 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif Herpes_UL6 PF01763.16 CRG85888.1 - 0.064 11.8 0.0 0.11 11.0 0.0 1.3 1 0 0 1 1 1 0 Herpesvirus UL6 like CH PF00307.31 CRG85888.1 - 0.075 13.2 0.5 11 6.3 0.0 2.3 2 0 0 2 2 2 0 Calponin homology (CH) domain RIFIN PF02009.16 CRG85889.1 - 0.065 13.1 0.3 0.18 11.7 0.3 1.7 1 1 0 1 1 1 0 Rifin ArsA_ATPase PF02374.15 CRG85889.1 - 0.55 9.3 3.0 0.84 8.7 3.0 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase RTA1 PF04479.13 CRG85890.1 - 5.8e-70 235.1 3.9 9.8e-70 234.4 3.9 1.3 1 0 0 1 1 1 1 RTA1 like protein DUF4131 PF13567.6 CRG85890.1 - 0.37 10.4 5.2 0.35 10.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF4233 PF14017.6 CRG85890.1 - 2.6 8.5 9.4 4.5 7.7 3.6 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4233) ING PF12998.7 CRG85891.1 - 9.5e-06 26.1 0.0 1.8e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 CRG85891.1 - 1.7e-05 24.6 7.1 1.7e-05 24.6 7.1 1.7 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 CRG85891.1 - 0.055 13.7 0.8 0.11 12.7 0.8 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 CRG85891.1 - 0.098 12.8 0.2 0.18 11.9 0.2 1.3 1 0 0 1 1 1 0 PHD-zinc-finger like domain PHD_2 PF13831.6 CRG85891.1 - 2.3 7.8 4.5 1.1 8.9 1.7 2.0 2 0 0 2 2 2 0 PHD-finger TENA_THI-4 PF03070.16 CRG85893.1 - 1.2e-07 31.7 0.0 0.00057 19.8 0.0 2.8 2 2 0 2 2 2 2 TENA/THI-4/PQQC family Cation_ATPase_C PF00689.21 CRG85894.1 - 5.1e-47 159.9 5.3 5.1e-47 159.9 5.3 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CRG85894.1 - 8.6e-37 126.4 0.2 8.6e-37 126.4 0.2 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 CRG85894.1 - 1.1e-22 79.9 0.0 2.3e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG85894.1 - 1.5e-17 64.6 0.0 3.4e-17 63.4 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG85894.1 - 2.6e-11 43.0 0.0 5.4e-10 38.8 0.0 2.6 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CRG85894.1 - 0.0023 17.7 0.1 0.055 13.2 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Ferlin_C PF16165.5 CRG85894.1 - 0.025 14.5 0.1 0.077 12.9 0.1 1.8 1 0 0 1 1 1 0 Ferlin C-terminus LptF_LptG PF03739.14 CRG85894.1 - 0.029 13.2 3.7 0.4 9.5 2.0 2.3 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG DUF1774 PF08611.10 CRG85894.1 - 0.28 11.5 7.1 0.15 12.4 0.4 2.8 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1774) DUF3325 PF11804.8 CRG85894.1 - 2.3 8.4 0.0 2.3 8.4 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3325) P16-Arc PF04699.14 CRG85895.1 - 3.6e-44 150.9 0.0 4.1e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Methyltransf_23 PF13489.6 CRG85896.1 - 2e-09 37.5 0.0 3e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85896.1 - 5.7e-09 36.5 0.0 1.2e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85896.1 - 1.5e-05 25.6 0.0 5.1e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85896.1 - 1.9e-05 25.3 0.0 4.3e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85896.1 - 3.3e-05 23.7 0.0 9.8e-05 22.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG85896.1 - 0.032 13.6 0.0 0.068 12.5 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Dynactin_p62 PF05502.13 CRG85897.1 - 1.5e-196 653.9 0.0 1.5e-196 653.9 0.0 1.6 2 0 0 2 2 2 1 Dynactin p62 family Mu-like_Com PF10122.9 CRG85897.1 - 4.5 6.8 6.5 5.7 6.5 2.1 2.8 2 0 0 2 2 2 0 Mu-like prophage protein Com Ribosomal_S7e PF01251.18 CRG85898.1 - 3.8e-81 271.2 0.1 4.5e-81 271.0 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e SGL PF08450.12 CRG85899.1 - 2.7e-07 30.4 0.2 6.2e-07 29.2 0.3 1.5 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 CRG85899.1 - 0.063 11.8 0.0 0.13 10.7 0.0 1.6 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ras PF00071.22 CRG85900.1 - 1.9e-55 186.9 0.0 3.2e-55 186.2 0.0 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CRG85900.1 - 5.1e-34 117.1 0.0 7.5e-34 116.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG85900.1 - 5.6e-13 48.7 0.0 9.9e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG85900.1 - 3e-05 23.7 0.0 4.3e-05 23.1 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CRG85900.1 - 0.00032 20.8 0.0 0.00052 20.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CRG85900.1 - 0.00065 19.1 0.0 0.001 18.5 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 CRG85900.1 - 0.0012 19.2 0.1 0.0024 18.3 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain Acetate_kinase PF00871.17 CRG85901.1 - 8.3e-92 307.9 0.0 9.6e-92 307.7 0.0 1.1 1 0 0 1 1 1 1 Acetokinase family XFP_N PF09364.10 CRG85902.1 - 2.6e-151 503.6 0.0 3.4e-151 503.2 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 CRG85902.1 - 2.7e-78 262.1 0.0 4.1e-78 261.5 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 CRG85902.1 - 2.1e-72 242.5 0.0 3.2e-72 241.9 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase TPP_enzyme_C PF02775.21 CRG85902.1 - 0.0022 17.8 0.2 0.0049 16.7 0.2 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain FAST_1 PF06743.15 CRG85902.1 - 0.059 13.3 0.7 2.9 7.9 0.0 2.6 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 Transket_pyr PF02779.24 CRG85902.1 - 0.089 12.5 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain HCO3_cotransp PF00955.21 CRG85903.1 - 2e-84 284.3 12.6 8e-46 156.9 5.5 2.1 1 1 1 2 2 2 2 HCO3- transporter family SF1-HH PF16275.5 CRG85904.1 - 2.7e-43 146.9 1.0 5.6e-43 145.9 1.0 1.5 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain GST_N PF02798.20 CRG85904.1 - 6.8e-13 48.8 0.0 1.2e-12 48.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CRG85904.1 - 7.3e-13 48.7 0.0 1.4e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain zf-CCHC PF00098.23 CRG85904.1 - 1.2e-11 44.1 11.1 2.1e-05 24.4 0.8 2.6 2 0 0 2 2 2 2 Zinc knuckle GST_C_3 PF14497.6 CRG85904.1 - 2.6e-11 43.6 0.0 5.9e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG85904.1 - 1.2e-10 41.6 0.0 2.8e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG85904.1 - 2.4e-10 40.5 0.0 8.9e-10 38.7 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain KH_1 PF00013.29 CRG85904.1 - 1.4e-07 31.2 0.1 2.7e-07 30.3 0.1 1.5 1 0 0 1 1 1 1 KH domain GST_C_2 PF13410.6 CRG85904.1 - 1.2e-06 28.5 0.0 2.5e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain zf-CCHC_3 PF13917.6 CRG85904.1 - 3.1e-06 27.0 5.7 0.0021 18.0 2.8 2.6 1 1 1 2 2 2 2 Zinc knuckle zf-CCHC_6 PF15288.6 CRG85904.1 - 0.0026 17.5 6.6 0.61 10.0 0.6 2.9 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 CRG85904.1 - 0.0035 17.0 5.0 0.68 9.7 0.4 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 CRG85904.1 - 0.022 14.5 0.5 0.022 14.5 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle Ferric_reduct PF01794.19 CRG85905.1 - 1.6e-20 73.5 11.6 4.7e-20 72.0 11.6 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG85905.1 - 2e-17 63.7 0.0 4.9e-15 56.0 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG85905.1 - 3.2e-12 46.5 0.0 2.7e-10 40.3 0.0 2.3 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 CRG85905.1 - 0.0016 19.0 0.0 0.0035 18.0 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain TFIIA PF03153.13 CRG85907.1 - 6.8 6.6 10.7 9.4 6.1 2.4 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CLU PF13236.6 CRG85908.1 - 2.8e-74 249.7 0.0 4.7e-74 249.0 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 CRG85908.1 - 1.2e-55 188.3 0.3 3.8e-55 186.6 0.0 2.1 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 CRG85908.1 - 5.1e-27 94.0 5.5 1.3e-12 47.9 0.0 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat CLU_N PF15044.6 CRG85908.1 - 2.1e-25 88.9 0.2 5.6e-25 87.5 0.2 1.8 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_10 PF13374.6 CRG85908.1 - 3.7e-22 77.5 0.6 6.1e-06 25.9 0.1 5.0 5 1 1 6 6 6 3 Tetratricopeptide repeat DUF727 PF05303.12 CRG85908.1 - 3.2e-05 23.9 0.0 9.6e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_2 PF07719.17 CRG85908.1 - 0.00011 22.0 0.3 0.37 11.0 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG85908.1 - 0.0028 17.7 3.0 0.068 13.4 0.7 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG85908.1 - 0.067 13.6 1.5 94 3.7 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat EnY2 PF10163.9 CRG85908.1 - 3 8.3 6.0 0.69 10.3 1.0 2.6 3 0 0 3 3 3 0 Transcription factor e(y)2 AAA_16 PF13191.6 CRG85909.1 - 6.9e-09 36.3 0.2 1.7e-08 35.1 0.2 1.7 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CRG85909.1 - 0.0017 18.3 0.0 0.0071 16.3 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase ATPase_2 PF01637.18 CRG85909.1 - 0.0049 16.8 0.0 0.0076 16.2 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CRG85909.1 - 0.016 14.7 0.0 0.032 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 CRG85909.1 - 0.025 14.6 0.1 0.12 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CRG85909.1 - 0.043 14.1 0.2 0.19 12.0 0.2 2.1 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 CRG85909.1 - 0.052 12.7 0.0 0.096 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CbiA PF01656.23 CRG85909.1 - 0.062 13.3 0.0 0.17 12.0 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 CRG85909.1 - 0.068 12.7 0.1 0.29 10.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF2914 PF11141.8 CRG85909.1 - 0.13 12.0 0.1 0.34 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) AAA PF00004.29 CRG85909.1 - 0.13 12.7 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) cobW PF02492.19 CRG85909.1 - 0.15 11.6 0.0 0.55 9.8 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RTA1 PF04479.13 CRG85911.1 - 2.8e-72 242.7 12.8 2.8e-72 242.7 12.8 1.4 2 0 0 2 2 2 1 RTA1 like protein Abhydrolase_9_N PF15420.6 CRG85911.1 - 0.012 15.7 2.7 0.012 15.7 2.7 2.1 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus DEAD PF00270.29 CRG85912.1 - 3.1e-41 141.1 0.0 1.4e-40 139.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG85912.1 - 4e-30 104.4 0.1 9e-30 103.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG85912.1 - 0.00014 21.9 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 CRG85912.1 - 0.018 13.7 0.0 0.027 13.2 0.0 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain RXT2_N PF08595.11 CRG85913.1 - 1.2 9.1 8.0 1.2 9.1 2.4 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF1793 PF08760.11 CRG85914.1 - 1.2e-71 240.6 0.3 2.5e-71 239.5 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 CRG85914.1 - 1.5e-61 207.1 0.3 4.2e-48 163.3 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4965) DUF5127 PF17168.4 CRG85914.1 - 6.1e-42 144.0 1.2 9.2e-42 143.4 1.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 CRG85914.1 - 0.0026 17.3 0.0 0.01 15.4 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4964) Stm1_N PF09598.10 CRG85915.1 - 3.1e-18 66.4 6.3 3.1e-18 66.4 6.3 4.2 4 1 0 4 4 4 1 Stm1 bZIP_1 PF00170.21 CRG85916.1 - 1e-05 25.5 8.4 2.2e-05 24.4 8.4 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CRG85916.1 - 0.0076 16.3 8.5 0.0076 16.3 8.5 2.0 2 0 0 2 2 2 1 Basic region leucine zipper Mit_KHE1 PF10173.9 CRG85916.1 - 0.11 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related ABC_tran_Xtn PF12848.7 CRG85916.1 - 5.9 7.0 11.2 1 9.4 6.8 2.0 2 0 0 2 2 2 0 ABC transporter Pex19 PF04614.12 CRG85917.1 - 9.3e-72 241.7 11.6 9.3e-72 241.7 11.6 2.1 2 0 0 2 2 2 1 Pex19 protein family DLIC PF05783.11 CRG85917.1 - 2.4 6.9 13.4 0.13 11.1 4.8 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) DUF4667 PF15700.5 CRG85917.1 - 3.8 7.5 8.1 5.9 6.9 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Ndc1_Nup PF09531.10 CRG85918.1 - 4.5 5.8 7.1 5.9 5.5 7.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mid2 PF04478.12 CRG85919.1 - 0.00011 22.1 0.1 0.00011 22.1 0.1 2.7 2 1 0 3 3 3 1 Mid2 like cell wall stress sensor Presenilin PF01080.17 CRG85919.1 - 0.52 9.0 2.5 0.67 8.7 2.5 1.3 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 CRG85919.1 - 1.8 7.4 11.6 2.4 7.0 11.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Mrx7 PF10906.8 CRG85920.1 - 7.4e-10 38.9 0.0 1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 MIOREX complex component 7 Y_phosphatase PF00102.27 CRG85921.1 - 1.9e-51 174.9 0.0 2.2e-50 171.4 0.0 2.0 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 CRG85921.1 - 0.002 18.1 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 CRG85921.1 - 0.0026 17.9 0.0 0.0058 16.8 0.0 1.6 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 CRG85921.1 - 0.033 14.0 0.7 0.12 12.2 0.7 1.9 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain VanZ PF04892.12 CRG85922.1 - 3.9e-07 30.8 1.4 6.2e-07 30.1 1.4 1.3 1 0 0 1 1 1 1 VanZ like family Bromodomain PF00439.25 CRG85923.1 - 1.9e-18 66.3 0.4 1.3e-17 63.6 0.2 2.4 2 0 0 2 2 2 1 Bromodomain Bromo_TP PF07524.13 CRG85923.1 - 1.9e-09 37.4 0.0 5.1e-09 36.0 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 CRG85923.1 - 0.055 13.6 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Histone-fold protein Piwi PF02171.17 CRG85924.1 - 5.1e-70 236.1 0.0 1.1e-69 235.0 0.0 1.5 2 0 0 2 2 2 1 Piwi domain ArgoN PF16486.5 CRG85924.1 - 1.2e-16 61.6 0.0 2.3e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute PAZ PF02170.22 CRG85924.1 - 2.3e-14 53.4 0.1 4e-14 52.6 0.1 1.4 1 0 0 1 1 1 1 PAZ domain ArgoL1 PF08699.10 CRG85924.1 - 3.7e-11 42.5 0.0 8.8e-11 41.3 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 CRG85924.1 - 1.3e-09 38.3 0.0 2.9e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 CRG85924.1 - 1.5e-06 28.4 0.0 4.3e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 Mid domain of argonaute Suf PF05843.14 CRG85925.1 - 2.1e-89 300.4 11.7 5.5e-89 299.1 0.0 4.0 5 0 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CRG85925.1 - 0.00034 21.2 0.8 1 10.4 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat HAT PF02184.16 CRG85925.1 - 0.0064 16.4 0.3 0.06 13.3 0.2 2.5 2 0 0 2 2 2 1 HAT (Half-A-TPR) repeat TPR_16 PF13432.6 CRG85925.1 - 0.018 15.7 0.4 0.28 11.9 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat ASF1_hist_chap PF04729.13 CRG85926.1 - 1.3e-73 246.0 0.0 1.7e-73 245.7 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 CRG85926.1 - 0.035 12.4 18.4 0.045 12.0 18.4 1.0 1 0 0 1 1 1 0 Nop14-like family Lgl_C PF08596.10 CRG85927.1 - 2.9e-129 431.2 0.0 5.2e-129 430.4 0.0 1.4 2 0 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 CRG85927.1 - 0.003 18.4 0.7 18 6.4 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG85927.1 - 0.011 16.0 0.0 13 6.2 0.0 4.3 4 2 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 CRG85928.1 - 4.3e-07 29.6 0.0 9.6e-07 28.4 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85928.1 - 1.5e-05 24.5 0.0 3.6e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG85928.1 - 0.041 13.2 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 CRG85928.1 - 0.12 12.3 0.2 0.76 9.7 0.3 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family APH PF01636.23 CRG85929.1 - 4.2e-06 26.9 0.1 7.5e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 CRG85929.1 - 0.048 12.9 0.1 2.9 7.0 0.0 2.1 2 0 0 2 2 2 0 Fructosamine kinase NACHT PF05729.12 CRG85930.1 - 3.2e-12 46.7 0.1 8.1e-12 45.4 0.1 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CRG85930.1 - 8e-10 39.1 0.0 3.3e-09 37.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain Ank_2 PF12796.7 CRG85930.1 - 2.8e-09 37.4 0.0 2.1e-06 28.2 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) THUMP PF02926.17 CRG85930.1 - 2.5e-08 34.1 0.0 1.4e-07 31.7 0.0 2.1 2 0 0 2 2 2 1 THUMP domain AAA_16 PF13191.6 CRG85930.1 - 2.8e-06 27.8 0.0 1.3e-05 25.6 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 CRG85930.1 - 2.1e-05 23.9 0.3 4.3e-05 22.9 0.3 1.5 1 0 0 1 1 1 1 KAP family P-loop domain Ank_5 PF13857.6 CRG85930.1 - 0.00011 22.4 0.0 4.6 7.7 0.0 4.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG85930.1 - 0.00045 20.7 0.1 0.14 12.8 0.0 3.7 3 1 0 3 3 3 1 Ankyrin repeats (many copies) ATPase_2 PF01637.18 CRG85930.1 - 0.00085 19.3 0.1 0.0019 18.2 0.1 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CRG85930.1 - 0.0064 16.5 0.0 0.046 13.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain Ank_3 PF13606.6 CRG85930.1 - 0.011 16.2 0.1 41 5.2 0.0 4.8 5 0 0 5 5 3 0 Ankyrin repeat RNA_helicase PF00910.22 CRG85930.1 - 0.048 14.1 0.0 0.37 11.2 0.0 2.3 2 0 0 2 2 2 0 RNA helicase PLAC9 PF15205.6 CRG85930.1 - 0.076 13.4 0.1 0.23 11.9 0.1 1.8 1 0 0 1 1 1 0 Placenta-specific protein 9 AAA PF00004.29 CRG85930.1 - 0.12 12.8 0.0 0.56 10.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SWI2_SNF2 PF18766.1 CRG85930.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase Pkinase PF00069.25 CRG85932.1 - 4.4e-63 213.1 0.0 6.4e-63 212.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG85932.1 - 3.2e-41 141.3 0.0 4.7e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG85932.1 - 7.3e-09 35.3 0.0 1.7e-06 27.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CRG85932.1 - 0.00041 19.2 0.0 0.0011 17.9 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CRG85932.1 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG85932.1 - 0.054 13.4 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAM_3 PF18016.1 CRG85932.1 - 0.1 12.4 0.2 0.31 10.9 0.2 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PTR2 PF00854.21 CRG85933.1 - 1.2e-58 198.9 6.0 1.2e-58 198.9 6.0 2.2 1 1 1 2 2 2 1 POT family Bromodomain PF00439.25 CRG85934.1 - 6.1e-25 87.1 0.2 1.2e-24 86.1 0.2 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CRG85934.1 - 5.5e-09 36.3 0.1 1.1e-08 35.4 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG85934.1 - 8.5e-08 32.2 0.0 1.6e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG85934.1 - 3.6e-05 24.1 0.1 6.5e-05 23.3 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltr_2 PF13718.6 CRG85934.1 - 0.052 13.0 0.0 0.085 12.2 0.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Sec34 PF04136.15 CRG85935.1 - 1.8e-49 167.5 1.5 4.7e-49 166.1 0.1 2.1 2 0 0 2 2 2 1 Sec34-like family RCC1 PF00415.18 CRG85936.1 - 7.3e-30 103.4 2.0 8.7e-06 26.3 0.0 7.0 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CRG85936.1 - 2.6e-14 52.6 21.9 2.3e-09 36.8 0.1 6.9 8 0 0 8 8 8 2 Regulator of chromosome condensation (RCC1) repeat Mcl1_mid PF12341.8 CRG85936.1 - 0.047 13.0 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region DNA_gyraseA_C PF03989.13 CRG85936.1 - 0.18 11.3 0.0 9.1 5.9 0.0 2.8 2 0 0 2 2 2 0 DNA gyrase C-terminal domain, beta-propeller NUC205 PF08168.11 CRG85936.1 - 0.2 11.2 0.4 0.51 9.9 0.1 1.8 2 0 0 2 2 2 0 NUC205 domain PUF PF00806.19 CRG85937.1 - 7.5e-17 60.0 0.0 0.035 13.8 0.0 8.0 8 0 0 8 8 8 6 Pumilio-family RNA binding repeat Pyridoxal_deC PF00282.19 CRG85938.1 - 1.5e-76 257.5 0.0 8.9e-76 255.0 0.0 1.9 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CRG85938.1 - 9.6e-07 28.1 0.0 1.3e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CRG85938.1 - 0.013 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase KduI PF04962.12 CRG85938.1 - 0.061 12.6 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 KduI/IolB family RINT1_TIP1 PF04437.13 CRG85939.1 - 1.9e-187 624.1 5.0 2.4e-187 623.8 0.1 2.1 2 0 0 2 2 2 1 RINT-1 / TIP-1 family YjeJ PF15922.5 CRG85939.1 - 0.35 10.0 4.8 1.6 7.9 1.8 2.4 2 0 0 2 2 2 0 YjeJ-like ADIP PF11559.8 CRG85939.1 - 0.58 10.2 10.3 1.6 8.8 10.3 1.7 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Phasin PF05597.11 CRG85939.1 - 0.72 9.9 8.4 2.8 7.9 0.1 3.4 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Het-C PF07217.11 CRG85939.1 - 0.99 7.9 3.3 1.9 6.9 2.7 1.7 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C TBCC_N PF16752.5 CRG85939.1 - 1.6 9.2 9.4 5 7.6 8.6 2.3 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain Baculo_PEP_C PF04513.12 CRG85939.1 - 2.1 8.4 6.5 14 5.7 0.0 3.8 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DNA_ligase_A_M PF01068.21 CRG85940.1 - 4e-51 173.6 0.5 2.5e-48 164.4 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CRG85940.1 - 1.5e-36 126.3 0.0 3e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CRG85940.1 - 7.2e-20 71.4 0.0 2.7e-19 69.6 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CRG85940.1 - 0.00065 20.0 0.0 0.0016 18.7 0.0 1.7 1 1 0 1 1 1 1 RNA ligase Whi5 PF08528.11 CRG85941.1 - 0.043 13.4 0.5 0.078 12.6 0.5 1.5 1 0 0 1 1 1 0 Whi5 like Metallopep PF12044.8 CRG85942.1 - 2.9e-169 563.2 0.1 3.9e-169 562.8 0.1 1.2 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_5 PF13688.6 CRG85942.1 - 0.012 15.7 0.9 0.025 14.7 0.9 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 CRG85942.1 - 0.082 12.8 0.5 0.16 11.8 0.5 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 CRG85942.1 - 0.14 12.6 0.1 0.34 11.4 0.1 1.7 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like CP2 PF04516.15 CRG85943.1 - 4.2e-79 265.1 0.0 6.8e-79 264.4 0.0 1.3 1 0 0 1 1 1 1 CP2 transcription factor Par3_HAL_N_term PF12053.8 CRG85943.1 - 0.062 13.5 0.6 0.12 12.5 0.6 1.4 1 0 0 1 1 1 0 N-terminal of Par3 and HAL proteins Clathrin PF00637.20 CRG85944.1 - 5.9e-18 65.1 0.8 5.7e-17 61.9 0.1 2.8 4 0 0 4 4 4 1 Region in Clathrin and VPS TPR_7 PF13176.6 CRG85944.1 - 0.024 14.6 0.8 10 6.4 0.3 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM176 PF14851.6 CRG85944.1 - 0.037 13.7 8.9 0.81 9.3 0.5 2.8 2 0 0 2 2 2 0 FAM176 family zf-RING_5 PF14634.6 CRG85944.1 - 0.069 13.1 3.1 0.045 13.7 0.8 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_11 PF17123.5 CRG85944.1 - 0.15 11.8 2.0 0.39 10.5 2.0 1.7 1 0 0 1 1 1 0 RING-like zinc finger PQQ_3 PF13570.6 CRG85944.1 - 0.2 12.2 0.7 1.2 9.7 0.1 2.5 2 0 0 2 2 2 0 PQQ-like domain WD40_like PF17005.5 CRG85944.1 - 0.22 10.8 0.0 0.42 9.9 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain Vps39_1 PF10366.9 CRG85944.1 - 0.26 11.6 1.0 0.99 9.7 0.2 2.3 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 zf-RING_2 PF13639.6 CRG85944.1 - 1.3 9.4 4.4 0.62 10.4 1.1 2.1 2 0 0 2 2 2 0 Ring finger domain FYDLN_acid PF09538.10 CRG85944.1 - 2.7 8.7 16.3 0.26 12.0 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) Afi1 PF07792.12 CRG85944.1 - 5.7 7.4 7.3 14 6.1 0.4 2.8 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF155 PF02582.14 CRG85945.1 - 1.8e-48 164.9 0.0 2.7e-48 164.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Ribonuclease_T2 PF00445.18 CRG85946.1 - 1.8e-43 148.9 1.2 1.8e-43 148.9 1.2 1.4 2 0 0 2 2 2 1 Ribonuclease T2 family GT-D PF08759.11 CRG85946.1 - 0.027 14.2 0.1 0.039 13.6 0.1 1.2 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold zf-H2C2_2 PF13465.6 CRG85947.1 - 4.2e-10 39.6 9.3 6e-05 23.3 0.2 3.0 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2 PF00096.26 CRG85947.1 - 2.8e-07 30.6 21.2 0.014 15.9 0.5 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG85947.1 - 0.00081 20.0 18.9 0.4 11.7 7.3 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger AT_hook PF02178.19 CRG85947.1 - 1.2 9.2 4.5 6 7.1 4.5 2.2 1 0 0 1 1 1 0 AT hook motif zf-C2H2_6 PF13912.6 CRG85947.1 - 6.6 6.9 9.5 26 5.0 0.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger ubiquitin PF00240.23 CRG85948.1 - 4.6e-34 116.0 0.6 7.9e-34 115.2 0.6 1.4 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_S27 PF01599.19 CRG85948.1 - 3.7e-27 94.2 2.1 3.7e-27 94.2 2.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 CRG85948.1 - 2.7e-16 59.2 0.7 4.9e-16 58.3 0.7 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CRG85948.1 - 2.8e-05 24.5 0.4 0.00013 22.4 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CRG85948.1 - 0.0012 19.0 0.6 0.0026 17.8 0.6 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CRG85948.1 - 0.004 17.5 0.6 0.0079 16.5 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CRG85948.1 - 0.0055 16.6 0.0 0.0082 16.1 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 CRG85948.1 - 0.013 16.0 0.7 0.019 15.6 0.7 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 CRG85948.1 - 0.021 14.9 1.0 5.9 7.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain IBR PF01485.21 CRG85948.1 - 0.03 14.5 0.2 0.05 13.8 0.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Glyco_hydro_18 PF00704.28 CRG85949.1 - 5.4e-86 289.1 0.5 6.2e-86 289.0 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Proteasome PF00227.26 CRG85951.1 - 2.6e-50 170.6 0.1 3.6e-50 170.1 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CRG85951.1 - 4.9e-13 48.5 0.3 8.3e-13 47.8 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Amidase_5 PF05382.13 CRG85951.1 - 0.071 13.0 0.0 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 Bacteriophage peptidoglycan hydrolase DUF2373 PF10180.9 CRG85952.1 - 3.1e-21 75.0 0.8 6.2e-21 74.0 0.8 1.6 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) GCP_C_terminal PF04130.13 CRG85953.1 - 1.2e-101 340.2 0.0 2e-101 339.6 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CRG85953.1 - 4.5e-84 282.7 0.0 5.9e-83 279.0 0.0 2.3 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal Aft1_HRA PF11786.8 CRG85954.1 - 3.9e-25 88.0 8.7 3.9e-25 88.0 8.7 3.3 2 1 1 3 3 3 1 Aft1 HRA domain Aft1_HRR PF11787.8 CRG85954.1 - 2.7e-23 82.9 6.5 2.7e-23 82.9 6.5 4.2 3 1 0 3 3 3 1 Aft1 HRR domain Aft1_OSA PF11785.8 CRG85954.1 - 3.3e-16 59.5 12.8 3.3e-16 59.5 12.8 3.2 3 0 0 3 3 3 1 Aft1 osmotic stress response (OSM) domain bZIP_1 PF00170.21 CRG85954.1 - 1.1e-12 47.8 4.7 1.9e-12 47.1 4.7 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CRG85954.1 - 1.3e-05 25.1 5.3 2.7e-05 24.2 5.3 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 CRG85954.1 - 0.0035 17.8 2.2 0.0073 16.8 2.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Transthyretin PF00576.21 CRG85955.1 - 4.2e-34 117.6 0.0 4.9e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 HIUase/Transthyretin family Big_1 PF02369.16 CRG85955.1 - 0.039 14.0 0.9 0.11 12.5 0.5 1.9 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) MG4 PF17789.1 CRG85955.1 - 0.039 14.1 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Macroglobulin domain MG4 ArsA_ATPase PF02374.15 CRG85956.1 - 3.3e-114 381.2 0.0 3.8e-114 381.0 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 CRG85956.1 - 3.2e-14 53.2 0.2 1.7e-12 47.6 0.0 2.6 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 CRG85956.1 - 3.5e-13 49.7 0.0 8.3e-13 48.5 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 CRG85956.1 - 1.7e-06 27.7 0.1 4.6e-06 26.3 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 CRG85956.1 - 9.1e-06 25.3 0.9 0.00017 21.1 0.1 2.3 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 CRG85956.1 - 2.9e-05 23.8 0.1 0.0014 18.3 0.0 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 CRG85956.1 - 7.7e-05 22.3 0.1 0.00033 20.2 0.0 2.0 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 CRG85956.1 - 0.028 14.0 0.3 0.087 12.4 0.3 1.9 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 CRG85956.1 - 0.048 13.1 0.1 0.14 11.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 CRG85956.1 - 0.049 14.0 0.0 0.08 13.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Acetyltransf_3 PF13302.7 CRG85958.1 - 4.5e-12 46.8 0.0 5.6e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain mRNA_decap_C PF16741.5 CRG85958.1 - 0.0043 16.3 0.2 0.012 14.9 0.2 1.7 1 1 0 1 1 1 1 mRNA-decapping enzyme C-terminus Acetyltransf_1 PF00583.25 CRG85958.1 - 0.0046 17.2 0.0 0.0089 16.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family CNOT1_CAF1_bind PF16415.5 CRG85958.1 - 0.11 11.8 0.1 0.17 11.3 0.1 1.1 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain eIF3_N PF09440.10 CRG85959.1 - 3.6e-51 173.1 2.5 3.6e-51 173.1 2.5 2.1 3 0 0 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 CRG85959.1 - 6.7e-14 52.3 0.0 2.7e-13 50.3 0.0 2.1 2 0 0 2 2 2 1 PCI domain Img2 PF05046.14 CRG85960.1 - 8.1e-26 90.1 0.0 1.7e-25 89.1 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) ARID PF01388.21 CRG85961.1 - 9e-19 67.9 0.0 2.4e-18 66.6 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain BAF250_C PF12031.8 CRG85961.1 - 0.032 13.5 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa AAA PF00004.29 CRG85962.1 - 4e-45 153.5 0.5 1.4e-44 151.7 0.0 2.1 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CRG85962.1 - 2.9e-10 39.9 0.1 2.1e-09 37.2 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 CRG85962.1 - 1.7e-08 34.6 0.1 6e-08 32.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CRG85962.1 - 8.2e-08 32.6 0.0 1.7e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CRG85962.1 - 2.1e-07 31.5 0.3 3.9e-05 24.1 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 CRG85962.1 - 2.5e-06 26.9 0.0 5.8e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 CRG85962.1 - 4.8e-05 23.6 0.7 0.01 16.1 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 CRG85962.1 - 0.00019 21.2 0.0 0.00045 20.0 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CRG85962.1 - 0.00023 21.0 0.0 0.0006 19.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 CRG85962.1 - 0.00032 20.2 0.0 0.0027 17.3 0.1 2.3 2 1 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 CRG85962.1 - 0.00038 21.0 0.0 0.0012 19.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CRG85962.1 - 0.00043 20.3 0.0 0.0015 18.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CRG85962.1 - 0.00066 20.0 0.1 0.0016 18.7 0.0 1.7 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 CRG85962.1 - 0.0018 18.6 0.0 0.004 17.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase NTPase_1 PF03266.15 CRG85962.1 - 0.0026 17.7 0.0 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 NTPase AAA_30 PF13604.6 CRG85962.1 - 0.0036 17.0 0.2 0.011 15.5 0.2 1.9 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 CRG85962.1 - 0.0042 17.1 0.0 0.01 15.8 0.0 1.6 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 CRG85962.1 - 0.0051 16.1 0.0 0.0093 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 CRG85962.1 - 0.0056 16.9 0.0 0.02 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 CRG85962.1 - 0.0058 16.5 0.0 0.018 14.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 CRG85962.1 - 0.0065 15.9 0.0 0.33 10.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 CRG85962.1 - 0.0068 16.1 0.1 0.024 14.3 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CRG85962.1 - 0.008 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CRG85962.1 - 0.0095 15.9 0.9 0.11 12.3 0.0 2.8 3 1 0 3 3 3 1 NACHT domain AAA_24 PF13479.6 CRG85962.1 - 0.022 14.5 0.2 0.053 13.2 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CRG85962.1 - 0.038 13.8 0.1 0.1 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain Bac_DnaA PF00308.18 CRG85962.1 - 0.04 13.7 0.0 0.077 12.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein ATPase_2 PF01637.18 CRG85962.1 - 0.054 13.4 1.0 0.33 10.8 0.0 2.5 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CRG85962.1 - 0.058 13.0 0.8 0.25 10.9 0.1 2.2 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.12 CRG85962.1 - 0.082 12.2 0.1 0.21 10.8 0.0 1.7 2 0 0 2 2 1 0 Zeta toxin Sigma54_activat PF00158.26 CRG85962.1 - 0.11 12.2 0.1 1.2 8.8 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 CRG85962.1 - 0.13 12.6 0.1 0.36 11.2 0.1 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 CRG85962.1 - 0.15 11.6 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Parvo_NS1 PF01057.17 CRG85962.1 - 0.21 10.6 0.0 0.37 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Asp PF00026.23 CRG85963.1 - 2.6e-108 362.2 0.2 3.1e-108 361.9 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG85963.1 - 1e-15 58.4 3.6 5.3e-14 52.8 2.7 2.6 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG85963.1 - 0.00012 22.7 0.1 1.3 9.7 0.0 3.2 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 CRG85963.1 - 0.0021 18.6 0.0 3 8.5 0.0 2.8 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 CRG85963.1 - 0.0027 17.5 0.0 0.035 13.9 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Keratin_2_head PF16208.5 CRG85963.1 - 0.15 12.2 1.3 0.25 11.5 1.3 1.3 1 0 0 1 1 1 0 Keratin type II head TAT_signal PF10518.9 CRG85963.1 - 1.3 9.0 7.5 2.2 8.3 7.5 1.4 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence NIF PF03031.18 CRG85964.1 - 3.5e-28 98.4 0.1 1e-27 96.8 0.0 1.8 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 CRG85964.1 - 4.7e-08 33.3 0.0 9.3e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CRG85964.1 - 8.4e-07 29.3 0.1 1.5e-05 25.3 0.0 2.4 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 CRG85964.1 - 0.00017 21.4 0.5 0.00051 19.9 0.1 1.9 2 0 0 2 2 2 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 CRG85964.1 - 0.013 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 CRG85964.1 - 0.027 14.8 0.0 0.069 13.5 0.0 1.7 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Biotin_lipoyl_2 PF13533.6 CRG85964.1 - 0.038 13.8 0.0 10 6.0 0.0 2.6 2 0 0 2 2 2 0 Biotin-lipoyl like MARVEL PF01284.23 CRG85965.1 - 8.5e-05 22.6 18.1 0.00017 21.6 18.1 1.5 1 1 0 1 1 1 1 Membrane-associating domain DUF1201 PF06716.11 CRG85965.1 - 0.37 10.8 4.1 13 5.8 0.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Papilloma_E5A PF05776.12 CRG85965.1 - 3.8 7.9 9.2 0.36 11.2 4.0 2.0 2 1 0 2 2 2 0 Papillomavirus E5A protein Arginase PF00491.21 CRG85966.1 - 3.9e-76 256.2 0.8 4.5e-76 256.0 0.8 1.0 1 0 0 1 1 1 1 Arginase family GatB_N PF02934.15 CRG85967.1 - 1.9e-95 319.4 0.0 2.4e-95 319.0 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 CRG85967.1 - 2.6e-23 82.5 0.0 4.3e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 GatB domain Sporozoite_P67 PF05642.11 CRG85968.1 - 0.38 8.8 10.2 0.69 7.9 10.2 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 CRG85968.1 - 0.75 7.8 21.2 1.3 7.1 21.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi FUSC PF04632.12 CRG85968.1 - 0.82 8.1 2.7 1.2 7.6 2.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Pox_Ag35 PF03286.14 CRG85968.1 - 1.1 9.0 22.2 0.54 10.0 1.1 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Nop14 PF04147.12 CRG85968.1 - 1.7 6.7 18.6 0.025 12.8 10.9 1.7 2 0 0 2 2 2 0 Nop14-like family RXT2_N PF08595.11 CRG85968.1 - 2.2 8.3 18.9 1.6 8.7 10.2 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4484 PF14831.6 CRG85968.1 - 4.9 7.1 15.2 3.2 7.7 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) NOA36 PF06524.12 CRG85968.1 - 5.4 6.2 27.4 0.093 12.0 19.3 1.9 2 0 0 2 2 2 0 NOA36 protein YqfQ PF14181.6 CRG85968.1 - 5.6 7.1 9.5 0.49 10.6 3.8 2.0 2 0 0 2 2 2 0 YqfQ-like protein Cwf_Cwc_15 PF04889.12 CRG85968.1 - 8.3 6.1 31.8 1 9.1 19.9 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Abhydrolase_3 PF07859.13 CRG85972.1 - 1.5e-13 51.1 0.0 2e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG85972.1 - 1.7e-07 31.0 0.0 0.00028 20.5 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 CRG85972.1 - 9.3e-06 24.5 0.0 0.013 14.2 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Chlorophyllase2 PF12740.7 CRG85972.1 - 9.7e-05 21.4 0.0 0.00013 21.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 CRG85972.1 - 0.0005 19.4 0.0 0.0016 17.8 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CRG85972.1 - 0.0082 16.0 0.0 0.093 12.5 0.0 2.0 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Esterase PF00756.20 CRG85972.1 - 0.01 15.5 0.0 0.037 13.7 0.0 1.8 2 0 0 2 2 2 1 Putative esterase Chlorophyllase PF07224.11 CRG85972.1 - 0.035 13.1 0.0 0.051 12.6 0.0 1.1 1 0 0 1 1 1 0 Chlorophyllase Esterase_phd PF10503.9 CRG85972.1 - 0.089 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase COesterase PF00135.28 CRG85972.1 - 0.24 10.2 0.0 0.62 8.9 0.0 1.5 2 0 0 2 2 2 0 Carboxylesterase family BBE PF08031.12 CRG85973.1 - 0.062 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Berberine and berberine like ECH_1 PF00378.20 CRG85974.1 - 5.5e-41 140.5 0.0 1.2e-40 139.4 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG85974.1 - 2.3e-28 99.7 0.0 2.8e-28 99.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase NB-ARC PF00931.22 CRG85975.1 - 2.5e-11 43.2 0.0 3.7e-10 39.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 CRG85975.1 - 2e-06 28.3 0.0 1.2e-05 25.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 CRG85975.1 - 0.00022 21.2 0.0 0.00047 20.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Zeta_toxin PF06414.12 CRG85975.1 - 0.00029 20.2 0.4 0.0013 18.1 0.0 2.2 3 0 0 3 3 3 1 Zeta toxin DUF676 PF05057.14 CRG85975.1 - 0.00069 19.2 0.0 0.0024 17.4 0.0 1.7 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CRG85975.1 - 0.0012 19.5 0.0 0.0012 19.5 0.0 3.1 3 1 0 3 3 2 1 Alpha/beta hydrolase family AAA_22 PF13401.6 CRG85975.1 - 0.002 18.4 0.0 0.0089 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CRG85975.1 - 0.0078 16.0 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CRG85975.1 - 0.018 15.3 0.0 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CRG85975.1 - 0.02 14.2 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 KaiC PGAP1 PF07819.13 CRG85975.1 - 0.064 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Exonuc_V_gamma PF04257.14 CRG85975.1 - 0.08 11.1 0.0 0.12 10.6 0.0 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit TniB PF05621.11 CRG85975.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_19 PF13245.6 CRG85975.1 - 0.11 12.8 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CRG85975.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 CRG85975.1 - 0.2 11.5 0.3 0.81 9.5 0.0 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Mannosyl_trans3 PF11051.8 CRG85976.1 - 3.6e-50 170.8 0.0 7.2e-50 169.9 0.0 1.5 1 1 0 1 1 1 1 Mannosyltransferase putative Gp_dh_C PF02800.20 CRG85976.1 - 0.072 12.7 0.1 0.17 11.4 0.1 1.7 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain VTC PF09359.10 CRG85976.1 - 0.11 11.9 0.1 0.21 11.0 0.1 1.3 1 0 0 1 1 1 0 VTC domain Methyltransf_23 PF13489.6 CRG85977.1 - 2.6e-21 76.1 0.0 3.7e-21 75.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG85977.1 - 2.7e-08 34.4 0.0 1.1e-07 32.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG85977.1 - 6.6e-08 32.5 0.0 1.5e-06 28.1 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG85977.1 - 3.1e-05 24.6 0.0 0.0025 18.5 0.0 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG85977.1 - 0.00015 22.4 0.0 0.00045 20.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG85977.1 - 0.036 13.6 0.0 0.088 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 CRG85977.1 - 0.037 13.5 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_2 PF00891.18 CRG85977.1 - 0.11 11.7 0.0 0.38 10.0 0.0 1.8 2 0 0 2 2 2 0 O-methyltransferase domain DUF697 PF05128.12 CRG85977.1 - 0.15 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF697) p450 PF00067.22 CRG85978.1 - 3.5e-35 121.6 0.1 2.7e-34 118.7 0.0 2.1 2 1 0 2 2 2 1 Cytochrome P450 ArgJ PF01960.18 CRG85979.1 - 0.032 12.9 2.5 0.038 12.7 2.5 1.1 1 0 0 1 1 1 0 ArgJ family DivIVA PF05103.13 CRG85979.1 - 0.13 12.4 2.5 0.16 12.0 2.5 1.1 1 0 0 1 1 1 0 DivIVA protein CsbD PF05532.12 CRG85979.1 - 0.65 9.9 13.4 0.49 10.3 2.0 2.9 2 1 1 3 3 3 0 CsbD-like FHA PF00498.26 CRG85980.1 - 2.8e-14 53.2 0.0 6.2e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CRG85980.1 - 0.086 13.2 0.0 1.2 9.4 0.0 2.2 1 1 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DnaJ PF00226.31 CRG85981.1 - 3e-09 36.9 1.5 7.5e-09 35.6 1.5 1.8 1 0 0 1 1 1 1 DnaJ domain Abhydrolase_3 PF07859.13 CRG85982.1 - 1.5e-40 139.3 0.0 2e-39 135.7 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG85982.1 - 4.9e-07 28.9 0.0 1.6e-06 27.3 0.0 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase Epimerase PF01370.21 CRG85985.1 - 1.2e-09 38.0 0.0 1.2e-07 31.4 0.0 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG85985.1 - 1e-06 28.5 0.0 1.9e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 CRG85985.1 - 0.00081 18.5 0.0 0.0044 16.1 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG85985.1 - 0.0048 16.1 0.0 0.008 15.4 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 CRG85985.1 - 0.042 12.9 0.0 0.73 8.9 0.0 2.1 2 0 0 2 2 2 0 RmlD substrate binding domain Semialdhyde_dh PF01118.24 CRG85985.1 - 0.15 12.5 0.0 0.46 10.9 0.0 1.9 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CRG85986.1 - 1.8e-06 27.2 0.9 1.8e-06 27.2 0.9 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG85986.1 - 2.6e-06 27.4 11.7 5.3e-06 26.4 11.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATG11 PF10377.9 CRG85988.1 - 1.3e-43 148.2 0.2 1.3e-43 148.2 0.2 3.8 4 0 0 4 4 4 1 Autophagy-related protein 11 APG17 PF04108.12 CRG85988.1 - 3.2e-07 29.8 3.3 3.7e-05 23.0 0.1 5.0 2 2 2 4 4 4 2 Autophagy protein Apg17 FokI_N PF02981.15 CRG85988.1 - 0.072 13.3 0.0 8.6 6.5 0.0 3.2 2 0 0 2 2 2 0 Restriction endonuclease FokI, recognition domain Pox_A_type_inc PF04508.12 CRG85988.1 - 3.5 7.6 17.0 7.8 6.5 0.9 5.6 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Sas6_CC PF18594.1 CRG85988.1 - 4.4 7.2 7.7 7.7 6.4 0.1 3.8 3 0 0 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain CENP-H PF05837.12 CRG85989.1 - 8.5e-33 113.1 17.2 5.4e-32 110.5 6.5 2.0 2 0 0 2 2 2 2 Centromere protein H (CENP-H) SatRNA_48 PF17485.2 CRG85989.1 - 0.053 12.6 1.0 0.057 12.5 0.1 1.6 2 0 0 2 2 2 0 Satellite RNA 48 kDa protein YusW PF14039.6 CRG85989.1 - 0.65 10.6 5.2 1.5 9.4 0.6 2.4 2 1 0 2 2 2 0 YusW-like protein HMG_box PF00505.19 CRG85991.1 - 3.7e-22 78.5 0.5 3.7e-22 78.5 0.5 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CRG85991.1 - 3.3e-15 56.4 0.7 6.2e-15 55.6 0.7 1.4 1 0 0 1 1 1 1 HMG-box domain YABBY PF04690.13 CRG85991.1 - 0.26 11.8 2.8 0.13 12.8 1.0 1.4 2 0 0 2 2 2 0 YABBY protein DUF4078 PF13300.6 CRG85993.1 - 2e-26 92.1 17.7 2e-26 92.1 17.7 2.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4078) Harakiri PF15196.6 CRG85993.1 - 0.2 12.2 2.5 0.65 10.5 2.5 1.8 1 0 0 1 1 1 0 Activator of apoptosis harakiri APG6_N PF17675.1 CRG85993.1 - 9.4 6.8 23.1 3.1 8.3 6.3 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region Homoserine_dh PF00742.19 CRG85994.1 - 1.8e-52 177.8 0.0 2.4e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 CRG85994.1 - 2e-15 57.5 0.0 5.4e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DUF3445 PF11927.8 CRG85995.1 - 2e-78 263.1 0.1 2.9e-78 262.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Aldo_ket_red PF00248.21 CRG85996.1 - 9.1e-14 51.3 0.0 1.2e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Kdo PF06293.14 CRG85997.1 - 2.2e-08 33.7 0.0 4.5e-06 26.2 0.0 2.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG85997.1 - 3.3e-06 27.2 2.0 0.017 15.1 0.3 2.9 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 CRG85997.1 - 6e-06 25.8 0.0 8.3e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 CRG85997.1 - 0.00019 21.1 0.0 0.13 11.9 0.0 2.4 2 0 0 2 2 2 2 RIO1 family Choline_kinase PF01633.20 CRG85997.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 CRG85997.1 - 0.11 11.2 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DHDPS PF00701.22 CRG85998.1 - 2.5e-39 134.7 0.1 3.2e-39 134.4 0.1 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family AcetylCoA_hyd_C PF13336.6 CRG85998.1 - 0.14 12.1 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain CbiM PF01891.16 CRG85999.1 - 0.029 14.2 0.4 0.029 14.2 0.4 3.0 2 1 1 3 3 3 0 Cobalt uptake substrate-specific transmembrane region COX14 PF14880.6 CRG85999.1 - 2 8.3 6.0 0.83 9.5 1.9 2.5 2 0 0 2 2 2 0 Cytochrome oxidase c assembly Methyltransf_2 PF00891.18 CRG86000.1 - 1.9e-28 99.2 0.0 3e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 CRG86000.1 - 2.6e-05 24.1 0.0 8.1e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Dimerisation domain Rrf2 PF02082.20 CRG86000.1 - 0.0018 18.5 0.0 0.0094 16.3 0.0 2.1 2 0 0 2 2 2 1 Transcriptional regulator Methyltransf_25 PF13649.6 CRG86000.1 - 0.0019 18.9 0.0 0.0042 17.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG86000.1 - 0.022 14.6 0.0 0.053 13.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Dimerisation PF08100.11 CRG86000.1 - 0.023 14.7 0.1 0.66 10.0 0.0 3.1 4 0 0 4 4 4 0 Dimerisation domain HTH_Crp_2 PF13545.6 CRG86000.1 - 0.064 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_20 PF12840.7 CRG86000.1 - 0.1 12.7 0.0 0.32 11.1 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Anp1 PF03452.14 CRG86001.1 - 7.6e-107 356.6 0.0 8.9e-107 356.4 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 CRG86001.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Mito_carr PF00153.27 CRG86002.1 - 7.9e-54 179.6 0.1 8.3e-19 67.3 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Zip PF02535.22 CRG86004.1 - 7.8e-60 202.8 10.8 5e-59 200.2 10.8 1.9 1 1 0 1 1 1 1 ZIP Zinc transporter Nop16 PF09420.10 CRG86005.1 - 1e-61 208.7 13.8 1.2e-61 208.5 13.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Pex24p PF06398.11 CRG86006.1 - 4.5e-87 292.4 0.0 5.6e-87 292.1 0.0 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 CRG86006.1 - 0.00016 20.2 5.6 0.0033 15.9 1.6 2.3 1 1 1 2 2 2 2 Protein of unknown function (DUF3292) DUF639 PF04842.12 CRG86006.1 - 0.0092 15.4 1.1 0.019 14.4 1.1 1.4 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) Ribosomal_L26 PF16906.5 CRG86007.1 - 5.7e-37 126.1 2.2 7e-37 125.8 2.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 CRG86007.1 - 8.3e-08 31.9 0.2 1.8e-07 30.9 0.2 1.5 1 0 0 1 1 1 1 KOW motif DUF1223 PF06764.11 CRG86007.1 - 0.024 14.6 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) Pkinase PF00069.25 CRG86008.1 - 5.7e-53 180.0 0.0 8.3e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86008.1 - 4.4e-20 72.0 0.0 7.3e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase WaaY PF06176.11 CRG86008.1 - 0.042 13.5 0.4 0.067 12.8 0.4 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.23 CRG86008.1 - 0.045 13.7 0.1 0.2 11.6 0.0 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 CRG86008.1 - 0.22 11.1 0.1 0.4 10.2 0.1 1.4 1 0 0 1 1 1 0 RIO1 family COPIIcoated_ERV PF07970.12 CRG86009.1 - 9.8e-36 123.7 0.3 2.6e-35 122.3 0.0 1.8 2 1 1 3 3 3 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CRG86009.1 - 6e-24 84.2 0.0 1e-23 83.5 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) ATP_transf PF09830.9 CRG86009.1 - 0.13 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 ATP adenylyltransferase Filament PF00038.21 CRG86010.1 - 4.8e-06 26.4 18.2 4.8e-06 26.4 18.2 3.8 2 1 2 4 4 4 2 Intermediate filament protein MscS_porin PF12795.7 CRG86010.1 - 1.1e-05 25.1 32.3 1.1e-05 25.1 32.3 3.9 2 1 2 4 4 4 2 Mechanosensitive ion channel porin domain APG17 PF04108.12 CRG86010.1 - 0.0044 16.2 34.1 0.019 14.1 19.7 2.7 1 1 1 2 2 2 2 Autophagy protein Apg17 Redoxin PF08534.10 CRG86011.1 - 7.6e-36 123.0 0.1 8.9e-36 122.8 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CRG86011.1 - 7e-12 45.3 0.0 8.9e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Stirrup PF09061.6 CRG86011.1 - 0.024 14.8 0.0 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 Stirrup FAD_binding_3 PF01494.19 CRG86012.1 - 2.2e-20 73.2 0.5 9e-20 71.2 0.5 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG86012.1 - 0.003 17.7 2.1 0.0033 17.6 0.5 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG86012.1 - 0.02 14.9 1.2 0.29 11.1 0.2 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 CRG86012.1 - 0.034 13.7 3.3 4 6.9 2.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF5318 PF17249.2 CRG86012.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5318) Trp_halogenase PF04820.14 CRG86012.1 - 0.12 11.2 2.2 0.49 9.2 0.8 2.0 1 1 1 2 2 2 0 Tryptophan halogenase SE PF08491.10 CRG86012.1 - 0.2 10.7 0.0 18 4.2 0.0 2.3 2 0 0 2 2 2 0 Squalene epoxidase AlaDh_PNT_C PF01262.21 CRG86012.1 - 1.8 7.8 4.3 41 3.4 4.3 2.2 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fungal_trans PF04082.18 CRG86013.1 - 2.4e-25 89.1 2.6 1.2e-24 86.8 1.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86013.1 - 0.0041 17.2 2.5 0.0078 16.3 2.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG86014.1 - 2.2e-41 141.9 23.1 2.2e-41 141.9 23.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG86014.1 - 3.5e-09 35.6 2.8 5.6e-09 35.0 2.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG86014.1 - 1.7e-08 33.8 27.4 4.9e-07 29.0 27.3 2.9 1 1 0 1 1 1 1 Sugar (and other) transporter PTR2 PF00854.21 CRG86014.1 - 0.01 14.7 0.2 0.01 14.7 0.2 1.9 2 0 0 2 2 2 0 POT family Nbas_N PF15492.6 CRG86014.1 - 0.027 13.8 0.0 0.087 12.1 0.0 1.8 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Ninjurin PF04923.12 CRG86014.1 - 0.21 11.5 1.7 2.7 8.0 0.1 2.6 2 0 0 2 2 2 0 Ninjurin DUF2721 PF11026.8 CRG86014.1 - 0.23 11.4 2.1 17 5.3 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) BT1 PF03092.16 CRG86014.1 - 0.24 9.6 4.7 0.06 11.6 0.4 2.2 3 0 0 3 3 3 0 BT1 family Pro-kuma_activ PF09286.11 CRG86015.1 - 9.6e-44 149.1 0.1 1.6e-43 148.4 0.1 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG86015.1 - 1.4e-06 27.8 2.3 2.4e-06 27.1 2.3 1.3 1 0 0 1 1 1 1 Subtilase family DUF2014 PF09427.10 CRG86016.1 - 2.2e-97 325.6 0.5 3.4e-97 324.9 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF2014) HLH PF00010.26 CRG86016.1 - 2.4e-17 62.6 0.1 7.9e-17 61.0 0.1 2.0 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.21 CRG86016.1 - 0.016 15.3 2.5 0.016 15.3 2.5 2.2 3 0 0 3 3 3 0 bZIP transcription factor TSC22 PF01166.18 CRG86016.1 - 0.57 10.5 2.1 3 8.2 0.9 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family NAD_binding_6 PF08030.12 CRG86017.1 - 1.6e-19 70.6 0.3 5.5e-11 42.8 0.0 2.7 2 1 0 2 2 2 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 CRG86017.1 - 0.0014 19.2 0.0 0.41 11.3 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF2070 PF09843.9 CRG86018.1 - 0.93 7.7 5.7 1.1 7.4 5.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FSH1 PF03959.13 CRG86019.1 - 1.4e-21 77.1 0.0 2.6e-21 76.3 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) RNase_PH PF01138.21 CRG86020.1 - 0.0001 22.8 0.0 0.00056 20.4 0.0 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 NAD_kinase PF01513.21 CRG86021.1 - 1.2e-81 274.1 0.0 1.6e-81 273.7 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase GAF_2 PF13185.6 CRG86022.1 - 5.1e-12 46.3 0.0 1.3e-11 44.9 0.0 1.7 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 CRG86022.1 - 2.1e-07 31.7 0.1 5.3e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 GAF domain bZIP_2 PF07716.15 CRG86022.1 - 1.4e-06 28.3 8.0 2.7e-06 27.4 8.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CRG86022.1 - 4.5e-05 23.5 8.1 8.3e-05 22.6 8.1 1.5 1 0 0 1 1 1 1 bZIP transcription factor Sugar_tr PF00083.24 CRG86023.1 - 3.2e-112 375.7 13.8 3.8e-112 375.4 13.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86023.1 - 8.3e-31 107.2 36.1 3.3e-28 98.6 15.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG86023.1 - 1.2e-05 24.0 12.2 0.00029 19.5 1.3 2.6 3 0 0 3 3 3 2 MFS/sugar transport protein TRI12 PF06609.13 CRG86023.1 - 3.2e-05 22.6 0.1 6.5e-05 21.6 0.1 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 CRG86023.1 - 0.00025 20.1 0.4 0.00068 18.7 0.4 1.7 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM DUF554 PF04474.12 CRG86023.1 - 0.27 10.7 8.4 0.027 13.9 3.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF554) DUF2561 PF10812.8 CRG86023.1 - 0.4 10.7 2.8 7.6 6.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2561) Methyltransf_23 PF13489.6 CRG86025.1 - 1.3e-19 70.6 0.0 1.8e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG86025.1 - 7.3e-09 36.2 0.0 1.9e-08 34.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG86025.1 - 5.7e-08 32.7 0.0 0.00084 19.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CRG86025.1 - 3.8e-06 27.6 0.0 5.9e-05 23.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG86025.1 - 1.2e-05 25.8 0.0 2.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 CRG86025.1 - 0.0044 16.8 0.0 0.007 16.1 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CRG86025.1 - 0.0051 16.3 0.0 0.0069 15.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CRG86025.1 - 0.0051 16.4 0.0 0.0088 15.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CRG86025.1 - 0.0088 15.5 0.0 0.022 14.2 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Importin_rep PF18773.1 CRG86025.1 - 0.064 13.0 0.0 0.2 11.4 0.0 1.8 1 0 0 1 1 1 0 Importin 13 repeat FtsJ PF01728.19 CRG86025.1 - 0.09 12.9 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 CRG86025.1 - 0.13 11.5 0.0 0.3 10.3 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase domain CMAS PF02353.20 CRG86025.1 - 0.15 11.3 0.0 0.28 10.5 0.0 1.5 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase p450 PF00067.22 CRG86026.1 - 1.2e-62 212.2 0.0 1.5e-62 211.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HsbA PF12296.8 CRG86027.1 - 4.4e-05 23.9 2.8 5.9e-05 23.5 2.8 1.1 1 0 0 1 1 1 1 Hydrophobic surface binding protein A UvrD-helicase PF00580.21 CRG86027.1 - 0.00027 20.5 0.2 0.00043 19.9 0.1 1.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain DUF4874 PF16173.5 CRG86027.1 - 0.01 15.5 0.4 0.04 13.6 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4874) Atypical_Card PF18461.1 CRG86027.1 - 0.12 12.6 0.1 0.23 11.7 0.1 1.6 1 1 1 2 2 2 0 Atypical caspase recruitment domain FA_hydroxylase PF04116.13 CRG86028.1 - 2.8e-23 82.7 10.0 2.8e-23 82.7 10.0 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily KR PF08659.10 CRG86029.1 - 3.2e-63 212.9 0.5 6.8e-63 211.8 0.5 1.6 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 CRG86029.1 - 5.8e-61 206.3 0.0 1.4e-60 205.0 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG86029.1 - 2.4e-58 197.8 0.0 3.5e-58 197.2 0.0 1.2 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG86029.1 - 8.5e-57 193.1 0.0 1.4e-56 192.4 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG86029.1 - 3e-30 104.7 0.1 6.5e-30 103.6 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG86029.1 - 1.9e-27 96.0 0.0 4e-27 94.9 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N_2 PF13602.6 CRG86029.1 - 1.3e-14 55.4 0.0 5e-14 53.5 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG86029.1 - 3.9e-11 42.8 0.6 1.6e-10 40.8 0.1 2.2 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 CRG86029.1 - 1.7e-10 40.9 0.0 5.7e-10 39.3 0.0 1.9 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG86029.1 - 3e-06 27.1 0.9 3e-06 27.1 0.9 2.3 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_23 PF13489.6 CRG86029.1 - 5.8e-06 26.2 0.1 2.8e-05 24.0 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG86029.1 - 0.00048 20.8 0.0 0.0016 19.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG86029.1 - 0.0021 17.9 0.0 0.0053 16.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG86029.1 - 0.014 16.0 0.0 0.084 13.5 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Thiolase_N PF00108.23 CRG86029.1 - 0.019 14.3 0.1 0.042 13.2 0.1 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Maf1 PF09174.10 CRG86030.1 - 7.1e-58 195.6 0.1 1e-57 195.1 0.1 1.2 1 0 0 1 1 1 1 Maf1 regulator Clat_adaptor_s PF01217.20 CRG86030.1 - 1.2e-50 171.1 0.8 1.8e-50 170.6 0.8 1.2 1 0 0 1 1 1 1 Clathrin adaptor complex small chain GTP_CH_N PF12471.8 CRG86031.1 - 1.2e-88 295.9 0.0 1.8e-88 295.4 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 CRG86031.1 - 6.9e-18 64.8 0.0 9.9e-18 64.3 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase II UPRTase PF14681.6 CRG86032.1 - 1.2e-52 178.4 0.2 9.3e-48 162.4 0.0 2.0 1 1 1 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CRG86032.1 - 0.00029 20.4 0.0 0.00036 20.1 0.0 1.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain DUF2220 PF09983.9 CRG86032.1 - 0.052 12.9 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria C-term(DUF2220) DEAD PF00270.29 CRG86033.1 - 1.9e-32 112.5 0.5 8.9e-32 110.3 0.1 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG86033.1 - 4.7e-24 84.9 0.1 1.5e-23 83.2 0.1 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CRG86033.1 - 0.012 15.4 0.1 0.048 13.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF2999 PF11212.8 CRG86033.1 - 0.046 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) tRNA-synt_1b PF00579.25 CRG86033.1 - 0.048 13.0 0.0 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) AAA_22 PF13401.6 CRG86033.1 - 0.14 12.5 0.5 0.91 9.8 0.5 2.3 1 1 0 1 1 1 0 AAA domain SH3_9 PF14604.6 CRG86034.1 - 8.9e-24 83.1 0.7 8.5e-13 48.0 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain FCH PF00611.23 CRG86034.1 - 3.2e-22 78.6 0.9 9.4e-22 77.1 0.0 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 CRG86034.1 - 1.9e-17 62.6 0.3 1.7e-08 34.0 0.0 2.5 2 0 0 2 2 2 2 SH3 domain C1_1 PF00130.22 CRG86034.1 - 5.2e-15 55.1 4.8 8.4e-15 54.4 4.8 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_2 PF07653.17 CRG86034.1 - 1.6e-05 24.5 0.0 0.074 12.8 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_10 PF17902.1 CRG86034.1 - 0.0003 20.8 0.0 1.3 9.1 0.0 2.8 2 0 0 2 2 2 2 SH3 domain C1_2 PF03107.16 CRG86034.1 - 0.018 15.3 4.5 0.036 14.4 4.5 1.4 1 0 0 1 1 1 0 C1 domain PBP PF01161.20 CRG86035.1 - 7.5e-14 52.2 0.0 9.6e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein MFS_1 PF07690.16 CRG86036.1 - 1.3e-33 116.5 23.3 1.3e-33 116.5 23.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily LapA_dom PF06305.11 CRG86036.1 - 0.044 13.6 0.1 0.044 13.6 0.1 2.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Glyco_hydro_72 PF03198.14 CRG86037.1 - 1.1e-136 455.2 2.0 1.3e-136 454.9 2.0 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 CRG86037.1 - 4.1e-06 26.4 0.1 1.6e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Fungal_trans PF04082.18 CRG86038.1 - 1.9e-29 102.5 0.0 5.2e-29 101.1 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86038.1 - 8.6e-06 25.8 8.9 2e-05 24.6 8.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ZZ PF00569.17 CRG86038.1 - 1.9 8.4 5.9 4.3 7.2 5.9 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type Choline_transpo PF04515.12 CRG86039.1 - 3e-83 279.7 23.9 3e-83 279.7 23.9 2.2 2 1 0 2 2 2 1 Plasma-membrane choline transporter Pex14_N PF04695.13 CRG86039.1 - 0.071 13.8 3.1 0.15 12.7 3.1 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GDPD PF03009.17 CRG86040.1 - 8.9e-36 123.9 0.0 1.2e-35 123.5 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CRG86040.1 - 5.5e-06 26.7 0.4 1.6e-05 25.2 0.4 1.8 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family CD34_antigen PF06365.12 CRG86040.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family LIM PF00412.22 CRG86041.1 - 2.7e-17 62.7 17.6 2.2e-10 40.6 2.9 2.9 3 0 0 3 3 3 2 LIM domain zf_UBZ PF18439.1 CRG86041.1 - 2.8 7.6 7.7 0.27 10.8 0.2 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger NAD_binding_5 PF07994.12 CRG86042.1 - 2.1e-143 477.5 0.0 2.8e-143 477.2 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 CRG86042.1 - 4.2e-45 152.5 0.4 8e-45 151.6 0.4 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase ADH_N PF08240.12 CRG86043.1 - 1.4e-25 89.2 1.9 3e-25 88.2 1.9 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG86043.1 - 1.9e-20 73.2 0.4 4.3e-20 72.0 0.4 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG86043.1 - 0.00012 22.4 0.1 0.00022 21.5 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 CRG86043.1 - 0.00084 18.7 0.8 0.0015 17.9 0.8 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG86043.1 - 0.0039 18.2 0.0 0.0086 17.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase IGFBP PF00219.18 CRG86043.1 - 0.023 15.3 0.4 0.089 13.5 0.4 2.0 1 0 0 1 1 1 0 Insulin-like growth factor binding protein Pep_deformylase PF01327.21 CRG86043.1 - 0.041 13.5 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Polypeptide deformylase TrkA_N PF02254.18 CRG86043.1 - 0.051 13.8 0.2 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain LpxI_C PF06230.11 CRG86043.1 - 0.056 13.3 0.8 0.11 12.4 0.8 1.4 1 0 0 1 1 1 0 LpxI C-terminal domain Imm70 PF15601.6 CRG86043.1 - 0.087 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 70 zf-Tim10_DDP PF02953.15 CRG86044.1 - 1e-19 69.9 3.3 1.5e-19 69.4 3.3 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 CRG86044.1 - 0.0018 17.9 2.5 0.0027 17.4 2.5 1.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF842) RhoGAP PF00620.27 CRG86045.1 - 4.6e-38 130.4 0.0 7.7e-38 129.7 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PIG-F PF06699.11 CRG86046.1 - 1.2e-70 237.4 5.8 1.4e-70 237.1 5.8 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Fungal_trans_2 PF11951.8 CRG86047.1 - 1.2e-05 24.3 6.8 3.8e-05 22.7 6.8 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86047.1 - 0.00025 21.1 1.9 0.00066 19.7 1.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Apyrase PF06079.11 CRG86048.1 - 0.025 13.8 0.0 0.042 13.1 0.0 1.2 1 0 0 1 1 1 0 Apyrase SlyX PF04102.12 CRG86048.1 - 0.45 11.2 2.5 19 5.9 0.2 2.9 2 1 0 2 2 2 0 SlyX AAA_11 PF13086.6 CRG86049.1 - 1.1e-64 218.7 1.3 2.2e-64 217.8 0.6 1.8 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 CRG86049.1 - 1.8e-51 174.6 0.0 4.2e-51 173.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG86049.1 - 8.1e-13 48.5 0.0 2.9e-11 43.5 0.0 2.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG86049.1 - 3.8e-09 37.0 0.0 1.2e-08 35.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CRG86049.1 - 4e-07 29.6 0.6 2e-06 27.3 0.5 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 CRG86049.1 - 9.9e-07 28.9 0.0 4.1e-06 26.9 0.0 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CRG86049.1 - 3.7e-05 24.0 0.1 0.00041 20.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 CRG86049.1 - 3.8e-05 23.4 0.3 9.4e-05 22.1 0.3 1.7 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 CRG86049.1 - 7.8e-05 22.5 0.0 0.2 11.3 0.0 2.6 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 CRG86049.1 - 0.00054 19.8 0.0 0.24 11.3 0.0 2.6 2 0 0 2 2 2 1 Helicase PhoH PF02562.16 CRG86049.1 - 0.0008 18.9 0.0 0.016 14.6 0.0 2.4 1 1 0 1 1 1 1 PhoH-like protein T2SSE PF00437.20 CRG86049.1 - 0.003 16.7 0.0 0.0072 15.4 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_24 PF13479.6 CRG86049.1 - 0.0062 16.3 0.0 0.022 14.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CRG86049.1 - 0.0064 16.9 0.1 0.018 15.4 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_10 PF12846.7 CRG86049.1 - 0.012 14.6 0.1 0.028 13.4 0.1 1.7 2 0 0 2 2 2 0 AAA-like domain AAA_25 PF13481.6 CRG86049.1 - 0.013 15.1 0.2 0.33 10.5 0.0 3.2 3 1 1 4 4 4 0 AAA domain AAA PF00004.29 CRG86049.1 - 0.025 15.0 0.0 0.18 12.2 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) 4HB_MCP_1 PF12729.7 CRG86049.1 - 0.025 14.1 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Flavi_DEAD PF07652.14 CRG86049.1 - 0.035 14.1 0.1 0.25 11.3 0.1 2.2 2 0 0 2 2 2 0 Flavivirus DEAD domain ABC_tran PF00005.27 CRG86049.1 - 0.085 13.4 0.2 0.24 11.9 0.2 1.8 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 CRG86049.1 - 0.092 12.7 0.0 0.49 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CRG86049.1 - 0.093 12.9 0.0 0.25 11.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain PIF1 PF05970.14 CRG86049.1 - 0.099 11.8 0.0 3.2 6.8 0.0 2.4 2 0 0 2 2 2 0 PIF1-like helicase IstB_IS21 PF01695.17 CRG86049.1 - 0.1 12.3 0.0 0.31 10.8 0.0 1.7 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_23 PF13476.6 CRG86049.1 - 0.12 12.9 5.0 1.5 9.3 0.0 2.8 3 0 0 3 3 2 0 AAA domain Mg_chelatase PF01078.21 CRG86049.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TK PF00265.18 CRG86049.1 - 0.16 11.8 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 Thymidine kinase HhH-GPD PF00730.25 CRG86051.1 - 7.8e-19 68.1 0.0 3.8e-18 65.9 0.0 2.0 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CRG86051.1 - 1.5e-09 37.3 0.0 5.9e-08 32.2 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CRG86051.1 - 0.13 12.9 0.0 0.65 10.6 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain UQ_con PF00179.26 CRG86052.1 - 3e-41 140.4 0.0 3.3e-41 140.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CRG86052.1 - 2.9e-05 23.8 0.0 4.7e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CRG86052.1 - 0.012 15.9 0.3 0.021 15.1 0.1 1.6 2 0 0 2 2 2 0 RWD domain UFC1 PF08694.11 CRG86052.1 - 0.03 14.0 0.0 0.042 13.5 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Miga PF10265.9 CRG86053.1 - 1 8.2 7.4 1.1 8.1 7.4 1.2 1 0 0 1 1 1 0 Mitoguardin TspO_MBR PF03073.15 CRG86055.1 - 2.5e-44 150.6 5.1 3.1e-44 150.3 5.1 1.1 1 0 0 1 1 1 1 TspO/MBR family MitoNEET_N PF10660.9 CRG86055.1 - 5.6 7.1 9.2 12 6.0 0.2 3.6 4 0 0 4 4 4 0 Iron-containing outer mitochondrial membrane protein N-terminus 2-Hacid_dh_C PF02826.19 CRG86056.1 - 9.6e-56 187.9 0.1 2.1e-55 186.8 0.1 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG86056.1 - 2.5e-38 130.8 0.0 4.8e-37 126.6 0.0 2.7 2 1 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 CRG86056.1 - 0.0008 19.5 0.3 0.0017 18.5 0.3 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 CRG86056.1 - 0.0038 17.7 0.0 0.01 16.3 0.0 1.8 1 0 0 1 1 1 1 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 CRG86056.1 - 0.06 12.6 4.8 0.2 11.0 4.8 1.9 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 CRG86056.1 - 0.077 13.2 2.8 0.062 13.5 0.6 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Rossmann-like PF10727.9 CRG86056.1 - 0.11 12.4 3.7 0.26 11.1 1.3 2.7 2 0 0 2 2 2 0 Rossmann-like domain DAO PF01266.24 CRG86056.1 - 0.33 10.5 3.1 2.2 7.8 0.8 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase ATP_sub_h PF10775.9 CRG86057.1 - 7.4e-27 93.2 2.8 1e-26 92.7 2.8 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h ATP-synt_F6 PF05511.11 CRG86057.1 - 0.00012 22.5 0.1 0.0002 21.7 0.0 1.4 2 0 0 2 2 2 1 Mitochondrial ATP synthase coupling factor 6 TFIIB PF00382.19 CRG86058.1 - 2.8e-32 110.6 0.0 2.7e-17 62.5 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 CRG86058.1 - 1.8e-10 40.2 1.1 4.2e-10 39.0 1.1 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding RB_B PF01857.20 CRG86058.1 - 0.00041 20.4 0.0 0.004 17.2 0.0 2.2 1 1 1 2 2 2 1 Retinoblastoma-associated protein B domain HTH_5 PF01022.20 CRG86058.1 - 0.0011 18.8 0.0 2.6 8.0 0.0 2.8 2 0 0 2 2 2 2 Bacterial regulatory protein, arsR family DUF1610 PF07754.11 CRG86058.1 - 0.037 14.0 1.6 0.83 9.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) HTH_Tnp_ISL3 PF13542.6 CRG86058.1 - 0.063 12.7 0.0 0.42 10.1 0.0 2.3 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 Cyclin_C PF02984.19 CRG86058.1 - 0.13 12.3 0.0 16 5.6 0.0 2.3 1 1 0 2 2 2 0 Cyclin, C-terminal domain eIF-5_eIF-2B PF01873.17 CRG86058.1 - 0.17 11.8 0.8 4.3 7.2 0.1 2.7 3 0 0 3 3 3 0 Domain found in IF2B/IF5 Sigma70_r4 PF04545.16 CRG86058.1 - 0.19 11.3 0.0 3.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 zf-ribbon_3 PF13248.6 CRG86058.1 - 0.21 11.1 5.2 7.7 6.1 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Aim21 PF11489.8 CRG86059.1 - 3e-221 737.2 80.2 3e-221 737.2 80.2 2.1 2 0 0 2 2 2 1 Altered inheritance of mitochondria protein 21 Cg6151-P PF10233.9 CRG86060.1 - 8.5e-42 142.0 13.6 1e-41 141.8 13.6 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P CitMHS PF03600.16 CRG86060.1 - 0.067 12.4 6.1 0.078 12.2 6.1 1.1 1 0 0 1 1 1 0 Citrate transporter Phage_holin_3_6 PF07332.11 CRG86060.1 - 0.34 11.0 11.9 0.4 10.7 4.7 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III NTF2 PF02136.20 CRG86061.1 - 2.6e-32 111.9 0.1 2.9e-32 111.7 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 CRG86061.1 - 0.015 15.7 0.0 0.018 15.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Surp PF01805.20 CRG86062.1 - 1.6e-09 37.6 0.0 3e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Surp module Polbeta PF18765.1 CRG86062.1 - 0.036 14.2 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase DUF4471 PF14740.6 CRG86062.1 - 0.067 12.4 0.1 0.17 11.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) SUIM_assoc PF16619.5 CRG86062.1 - 1.1 9.3 8.6 0.09 12.8 2.9 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF5308 PF17233.2 CRG86062.1 - 3.4 7.9 8.8 1.1 9.4 4.3 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5308) Spt20 PF12090.8 CRG86062.1 - 6.4 6.3 9.4 14 5.2 9.4 1.5 1 0 0 1 1 1 0 Spt20 family MFS_1 PF07690.16 CRG86064.1 - 1.4e-15 57.1 40.0 1.1e-14 54.2 39.7 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRIQK PF15168.6 CRG86064.1 - 4.3 7.3 7.7 0.47 10.4 0.5 3.0 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family Glyco_hydro_18 PF00704.28 CRG86065.1 - 9.9e-88 294.8 9.7 1.2e-87 294.6 9.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 BTB PF00651.31 CRG86066.1 - 8e-14 51.8 0.0 6.5e-12 45.7 0.0 3.0 1 1 2 3 3 3 1 BTB/POZ domain DUF1765 PF08578.10 CRG86067.1 - 2.1e-43 147.8 7.1 7.3e-43 146.0 6.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) TFR_dimer PF04253.15 CRG86068.1 - 7.7e-38 129.3 0.0 1.4e-37 128.5 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CRG86068.1 - 1.1e-16 61.2 0.0 3.6e-16 59.5 0.0 1.9 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CRG86068.1 - 7.4e-14 51.5 0.1 1.5e-13 50.6 0.1 1.5 1 0 0 1 1 1 1 PA domain Nicastrin PF05450.15 CRG86068.1 - 0.0089 15.5 0.0 0.27 10.7 0.0 2.2 2 0 0 2 2 2 1 Nicastrin HMG_CoA_synt_C PF08540.10 CRG86069.1 - 2.5e-106 355.4 0.4 3.1e-106 355.1 0.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 CRG86069.1 - 7.5e-96 319.0 0.1 1.2e-95 318.3 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal Glyco_hydro_64 PF16483.5 CRG86071.1 - 6.5e-119 397.5 1.4 7.8e-119 397.2 1.4 1.1 1 0 0 1 1 1 1 Beta-1,3-glucanase K_oxygenase PF13434.6 CRG86072.1 - 4.8e-17 62.1 0.0 1.9e-10 40.4 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG86072.1 - 2.7e-08 33.5 0.0 0.0027 17.0 0.0 3.0 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG86072.1 - 1.4e-05 24.5 0.0 0.064 12.5 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG86072.1 - 0.00023 21.2 0.1 0.7 9.9 0.2 2.8 2 1 0 2 2 2 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG86072.1 - 0.0041 16.2 0.0 0.0076 15.3 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CRG86072.1 - 0.0052 16.4 2.4 0.22 11.1 0.4 3.5 3 1 0 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG86072.1 - 0.0055 15.4 0.0 0.11 11.2 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 CRG86072.1 - 0.011 16.0 0.1 0.13 12.5 0.0 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 CRG86072.1 - 0.017 14.4 0.1 0.035 13.3 0.0 1.5 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 CRG86072.1 - 0.022 14.0 0.0 0.053 12.7 0.0 1.6 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 CRG86072.1 - 0.093 11.8 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 CRG86072.1 - 0.18 11.8 0.1 16 5.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.22 CRG86073.1 - 3.5e-09 37.5 0.0 7.2e-09 36.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG86073.1 - 2.7e-05 24.1 0.0 7.5e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain PGM_PMM_I PF02878.16 CRG86074.1 - 2.5e-34 117.9 0.1 3.7e-34 117.4 0.1 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 CRG86074.1 - 7e-25 87.4 0.0 1.3e-24 86.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 CRG86074.1 - 6.3e-16 58.9 0.0 1.3e-15 57.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 CRG86074.1 - 1.1e-07 32.0 0.0 2.4e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RNase_T PF00929.24 CRG86076.1 - 1.1e-18 68.4 0.0 1.8e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Exonuclease DUF4962 PF16332.5 CRG86076.1 - 0.12 10.9 5.7 0.19 10.2 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) MmgE_PrpD PF03972.14 CRG86077.1 - 1.9e-115 386.0 0.0 2.2e-115 385.7 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family polyprenyl_synt PF00348.17 CRG86078.1 - 7.5e-43 146.4 0.0 4e-27 94.9 0.0 2.6 2 1 1 3 3 3 2 Polyprenyl synthetase Terpene_synth_C PF03936.16 CRG86078.1 - 0.013 14.9 0.6 0.087 12.1 0.1 2.5 3 0 0 3 3 3 0 Terpene synthase family, metal binding domain Gti1_Pac2 PF09729.9 CRG86079.1 - 0.79 9.8 3.4 1.1 9.3 0.9 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Cwf_Cwc_15 PF04889.12 CRG86079.1 - 3.7 7.2 17.4 3 7.5 3.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Glyco_hydro_3 PF00933.21 CRG86080.1 - 5.6e-85 285.5 0.0 8.1e-85 285.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 CRG86080.1 - 1.8e-18 66.8 0.0 3.2e-10 40.3 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG86080.1 - 6.7e-14 52.1 0.0 3.3e-07 30.6 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG86080.1 - 1.1e-13 51.2 0.0 8.5e-08 32.2 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG86080.1 - 3.9e-09 36.7 0.0 0.005 16.9 0.0 2.7 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Glyco_hydro_3_C PF01915.22 CRG86080.1 - 4.2e-06 26.9 0.0 1.3e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_CG PF14542.6 CRG86080.1 - 0.0057 16.8 0.1 2 8.6 0.0 2.7 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CRG86080.1 - 0.0074 16.2 0.0 8.3 6.5 0.0 2.9 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_6 PF13480.7 CRG86080.1 - 0.034 14.3 0.0 3.4 7.8 0.0 2.9 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PHP_C PF13263.6 CRG86080.1 - 0.13 12.0 0.6 0.5 10.2 0.1 2.2 2 0 0 2 2 2 0 PHP-associated MFS_1 PF07690.16 CRG86081.1 - 1.6e-48 165.4 52.0 8e-48 163.2 36.8 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86081.1 - 4.7e-11 42.2 23.6 3.7e-10 39.3 23.6 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter ABC_tran PF00005.27 CRG86082.1 - 1.5e-46 158.3 0.0 6.3e-26 91.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG86082.1 - 1.4e-37 129.8 22.9 9.9e-24 84.4 5.7 3.4 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG86082.1 - 1.4e-09 37.8 5.1 0.02 14.3 2.1 4.0 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG86082.1 - 2.4e-06 27.6 1.5 0.93 9.2 0.0 4.6 5 0 0 5 5 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CRG86082.1 - 0.00036 21.1 1.5 0.027 15.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG86082.1 - 0.00086 19.6 2.6 1.9 8.7 0.0 3.3 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CRG86082.1 - 0.0012 18.6 0.1 0.55 9.9 0.0 3.5 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_25 PF13481.6 CRG86082.1 - 0.0012 18.4 0.3 0.08 12.5 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CRG86082.1 - 0.0014 19.1 1.0 0.087 13.2 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CRG86082.1 - 0.0038 17.6 0.9 0.99 9.8 0.0 3.5 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 CRG86082.1 - 0.005 15.9 0.6 0.29 10.2 0.1 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein SbcCD_C PF13558.6 CRG86082.1 - 0.0086 16.3 0.1 6.3 7.1 0.0 2.9 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Dynamin_N PF00350.23 CRG86082.1 - 0.011 15.8 2.1 0.12 12.4 0.0 3.0 3 0 0 3 3 3 0 Dynamin family AAA_29 PF13555.6 CRG86082.1 - 0.012 15.3 0.5 4.2 7.2 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AIG1 PF04548.16 CRG86082.1 - 0.023 14.1 1.4 0.3 10.4 0.6 2.4 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 CRG86082.1 - 0.023 14.6 0.2 0.18 11.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 CRG86082.1 - 0.048 13.4 0.1 5.2 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 CRG86082.1 - 0.063 13.0 0.1 0.82 9.4 0.0 2.5 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase MMR_HSR1 PF01926.23 CRG86082.1 - 0.067 13.3 0.5 6.3 6.9 0.1 2.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 CRG86082.1 - 0.078 12.9 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CRG86082.1 - 0.19 11.2 0.3 5.7 6.4 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 CRG86082.1 - 0.23 12.0 0.2 24 5.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CRG86082.1 - 1.6 8.8 6.5 0.28 11.2 0.8 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain MFS_1 PF07690.16 CRG86083.1 - 6.6e-42 143.7 33.2 6.6e-42 143.7 33.2 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Oxysterol_BP PF01237.18 CRG86084.1 - 1.2e-62 211.9 9.6 2.2e-60 204.5 9.6 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein CUE PF02845.16 CRG86086.1 - 6.5e-11 41.7 0.0 1e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain Presenilin PF01080.17 CRG86088.1 - 4.9 5.8 8.0 5.9 5.5 8.0 1.0 1 0 0 1 1 1 0 Presenilin AlaDh_PNT_N PF05222.15 CRG86089.1 - 4.1e-29 101.6 0.0 6.2e-29 101.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 CRG86089.1 - 4.5e-07 29.4 0.0 1.3e-05 24.6 0.0 2.5 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ThiC-associated PF13667.6 CRG86089.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 ThiC-associated domain UCH PF00443.29 CRG86090.1 - 1.3e-35 123.1 0.0 2.7e-30 105.7 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG86090.1 - 1.1e-07 31.8 2.9 2.3e-06 27.4 2.9 2.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TniQ PF06527.11 CRG86090.1 - 0.095 13.4 0.1 0.63 10.8 0.0 2.2 2 0 0 2 2 2 0 TniQ MAGI_u1 PF16663.5 CRG86090.1 - 0.24 11.5 4.3 7.6 6.7 0.8 2.7 2 0 0 2 2 2 0 Unstructured region on MAGI Aminotran_1_2 PF00155.21 CRG86091.1 - 0.00011 21.5 0.0 0.00016 21.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II F_bP_aldolase PF01116.20 CRG86092.1 - 9.1e-92 307.5 0.0 1e-91 307.3 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II RSN1_7TM PF02714.15 CRG86093.1 - 6.2e-79 265.2 20.9 9.6e-79 264.5 20.9 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CRG86093.1 - 3.2e-43 148.0 0.0 4.7e-43 147.4 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CRG86093.1 - 2.4e-37 128.1 0.6 2.4e-37 128.1 0.6 3.3 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport Dynamin_N PF00350.23 CRG86094.1 - 3.4e-29 102.1 0.0 8.6e-29 100.7 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CRG86094.1 - 7.9e-18 64.7 0.0 9.4e-16 57.9 0.0 2.3 2 0 0 2 2 2 2 Dynamin central region MMR_HSR1 PF01926.23 CRG86094.1 - 4.6e-06 26.7 0.9 0.00024 21.2 0.0 3.4 2 2 1 3 3 3 1 50S ribosome-binding GTPase GED PF02212.18 CRG86094.1 - 0.0038 17.3 0.0 0.018 15.1 0.0 2.3 1 1 0 1 1 1 1 Dynamin GTPase effector domain BCAS2 PF05700.11 CRG86094.1 - 0.026 14.2 0.4 0.071 12.8 0.4 1.7 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) AAA_16 PF13191.6 CRG86094.1 - 0.039 14.4 0.9 1.2 9.5 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain DUF5044 PF16447.5 CRG86094.1 - 0.16 11.8 0.2 2.4 7.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5044) FlxA PF14282.6 CRG86094.1 - 0.57 10.2 6.2 1.7 8.7 1.0 2.6 2 0 0 2 2 2 0 FlxA-like protein Peptidase_S10 PF00450.22 CRG86095.1 - 1.9e-94 317.5 0.0 2.4e-94 317.2 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Aldo_ket_red PF00248.21 CRG86096.1 - 2.5e-39 135.2 0.0 7.2e-29 100.9 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family STE2 PF02116.15 CRG86097.1 - 3e-96 322.0 20.1 3.5e-96 321.8 20.1 1.0 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR Iron_permease PF04120.12 CRG86097.1 - 0.076 12.8 0.1 0.24 11.2 0.0 1.8 2 0 0 2 2 2 0 Low affinity iron permease HlyIII PF03006.20 CRG86097.1 - 0.41 10.3 11.0 0.63 9.7 11.0 1.4 1 1 0 1 1 1 0 Haemolysin-III related Solute_trans_a PF03619.16 CRG86098.1 - 1.2e-57 195.5 19.3 1.6e-57 195.1 19.3 1.2 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Dicty_CAR PF05462.11 CRG86099.1 - 2.6e-09 36.7 6.1 2.6e-09 36.7 6.1 2.0 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor Git3 PF11710.8 CRG86099.1 - 4.3e-05 23.4 17.4 0.00029 20.7 14.0 2.5 2 1 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 CRG86099.1 - 9.2e-05 21.9 3.2 0.00015 21.2 3.2 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF962 PF06127.11 CRG86099.1 - 0.22 11.6 2.4 1.8 8.7 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF962) 7TM_GPCR_Srsx PF10320.9 CRG86099.1 - 0.24 10.7 13.1 0.02 14.3 8.3 1.6 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srsx YMF19 PF02326.15 CRG86099.1 - 0.25 12.2 0.1 0.25 12.2 0.1 2.7 3 0 0 3 3 3 0 Plant ATP synthase F0 Frizzled PF01534.17 CRG86099.1 - 1 8.3 13.7 2.3 7.2 10.0 2.6 1 1 1 2 2 2 0 Frizzled/Smoothened family membrane region TauD PF02668.16 CRG86100.1 - 4.4e-37 128.4 0.3 7e-37 127.7 0.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CRG86101.1 - 1.2e-14 54.1 26.5 1.2e-14 54.1 26.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG86101.1 - 7.7e-10 38.7 5.5 1.8e-09 37.5 5.5 1.6 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 CRG86101.1 - 0.0005 19.1 6.9 0.0005 19.1 6.9 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter UEV PF05743.13 CRG86102.1 - 8.6e-35 119.2 0.0 1.3e-34 118.6 0.0 1.3 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 CRG86102.1 - 1.1e-21 76.5 0.0 2e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 CRG86102.1 - 0.022 14.4 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Spidroin_N PF16763.5 CRG86102.1 - 0.039 14.0 0.2 0.086 12.9 0.2 1.5 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term ATG16 PF08614.11 CRG86102.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.6 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) ADIP PF11559.8 CRG86102.1 - 0.28 11.3 2.5 0.47 10.5 2.5 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Aldedh PF00171.22 CRG86103.1 - 5e-139 463.8 0.0 5.7e-139 463.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CRG86103.1 - 0.0032 16.6 0.0 0.005 15.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1344 PF07076.11 CRG86103.1 - 0.0062 16.4 0.0 4.7 7.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1344) NMO PF03060.15 CRG86104.1 - 1.2e-28 100.5 4.6 2.6e-20 73.1 1.4 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 CRG86104.1 - 4.4e-07 29.2 1.2 8.1e-07 28.4 1.2 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CRG86104.1 - 5.6e-07 28.9 5.4 8.5e-07 28.3 2.8 2.0 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CRG86104.1 - 0.00018 20.7 0.6 0.00027 20.2 0.6 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase G3P_antiterm PF04309.12 CRG86104.1 - 0.046 13.1 0.0 0.37 10.2 0.1 2.4 3 0 0 3 3 3 0 Glycerol-3-phosphate responsive antiterminator His_biosynth PF00977.21 CRG86104.1 - 0.067 12.6 0.0 0.16 11.4 0.0 1.6 1 1 0 1 1 1 0 Histidine biosynthesis protein NAD_binding_1 PF00175.21 CRG86105.1 - 2.2e-17 63.6 0.0 5.4e-17 62.4 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Globin PF00042.22 CRG86105.1 - 1.2e-09 38.7 0.0 3.1e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Globin NAD_binding_6 PF08030.12 CRG86105.1 - 2.1e-08 34.4 0.0 9.7e-06 25.8 0.0 3.1 2 1 1 3 3 3 2 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 CRG86105.1 - 5.8e-06 26.6 0.0 1.1e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Protoglobin PF11563.8 CRG86105.1 - 0.049 13.5 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Protoglobin Glyco_tranf_2_3 PF13641.6 CRG86106.1 - 1.7e-08 34.6 0.3 6.1e-08 32.8 0.1 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CRG86106.1 - 7.9e-07 29.2 15.6 1.6e-05 24.9 15.6 2.3 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 CRG86106.1 - 2.1e-05 24.1 0.0 0.00011 21.7 0.0 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 CRG86106.1 - 0.00024 19.9 0.0 0.0079 14.9 0.0 2.3 1 1 0 1 1 1 1 Chitin synthase SpoVAD PF07451.11 CRG86106.1 - 0.036 12.8 0.0 0.055 12.2 0.0 1.1 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Acyl_transf_3 PF01757.22 CRG86107.1 - 8.4e-28 97.4 34.2 1.9e-27 96.3 34.2 1.5 1 1 0 1 1 1 1 Acyltransferase family TauD PF02668.16 CRG86108.1 - 1e-29 104.2 0.2 2.5e-29 102.9 0.2 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CRG86109.1 - 4.3e-30 104.8 14.3 5.3e-30 104.5 14.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily SID-1_RNA_chan PF13965.6 CRG86109.1 - 5.5e-05 21.8 1.9 0.0057 15.1 1.2 2.1 2 0 0 2 2 2 2 dsRNA-gated channel SID-1 DUF2776 PF10951.8 CRG86109.1 - 0.0029 16.9 0.3 0.0071 15.6 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2776) Peptidase_S10 PF00450.22 CRG86110.1 - 4.8e-73 247.0 0.2 6.5e-73 246.5 0.2 1.2 1 0 0 1 1 1 1 Serine carboxypeptidase YXWGXW PF12779.7 CRG86110.1 - 0.4 10.9 5.8 5.5 7.2 0.2 2.5 2 0 0 2 2 2 0 YXWGXW repeat (2 copies) MFS_1 PF07690.16 CRG86111.1 - 1.2e-32 113.3 35.6 1.2e-32 113.3 35.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3522 PF12036.8 CRG86111.1 - 0.0069 16.7 0.3 0.0069 16.7 0.3 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF3522) BAR PF03114.18 CRG86112.1 - 2.8e-65 220.3 6.7 3.7e-65 219.9 6.7 1.2 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 CRG86112.1 - 3e-15 55.5 0.0 6.1e-15 54.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG86112.1 - 1e-13 50.9 0.1 1.8e-13 50.1 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CRG86112.1 - 1.1e-09 37.8 0.3 3e-09 36.4 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain CT_C_D PF02682.16 CRG86112.1 - 0.072 12.8 0.4 0.16 11.7 0.2 1.6 2 0 0 2 2 2 0 Carboxyltransferase domain, subdomain C and D Vps5 PF09325.10 CRG86112.1 - 0.11 12.1 6.0 0.67 9.5 2.3 2.3 2 0 0 2 2 2 0 Vps5 C terminal like TMPIT PF07851.13 CRG86112.1 - 2.6 7.2 6.8 7.3 5.7 0.0 2.1 1 1 1 2 2 2 0 TMPIT-like protein BRE1 PF08647.11 CRG86112.1 - 2.9 8.0 10.5 6.8 6.8 0.6 2.5 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Jnk-SapK_ap_N PF09744.9 CRG86112.1 - 5.4 7.2 10.8 15 5.8 3.9 2.6 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Aminotran_5 PF00266.19 CRG86113.1 - 3.2e-94 315.9 0.0 4e-94 315.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CRG86113.1 - 5.5e-06 25.9 0.0 8.7e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CRG86113.1 - 0.00062 19.2 0.0 0.0019 17.6 0.1 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CRG86113.1 - 0.021 13.4 0.0 0.03 12.9 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Pyridoxal_deC PF00282.19 CRG86113.1 - 0.025 13.3 0.0 0.048 12.4 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain IDO PF01231.18 CRG86114.1 - 3e-163 543.6 0.0 3.4e-163 543.5 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 CRG86114.1 - 0.031 13.0 0.0 0.54 8.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1864) CsbD PF05532.12 CRG86115.1 - 2.9e-11 43.1 15.7 4.7e-10 39.2 2.1 3.4 2 1 1 3 3 3 2 CsbD-like DUF3712 PF12505.8 CRG86116.1 - 1.7e-27 96.2 3.3 1.8e-26 92.8 0.5 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF3712) DUF2236 PF09995.9 CRG86117.1 - 2.5e-35 122.7 0.4 3.5e-35 122.2 0.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) FIVAR PF07554.13 CRG86118.1 - 0.22 12.3 9.8 2.4 9.0 3.9 2.4 2 0 0 2 2 2 0 FIVAR domain SnoaL_4 PF13577.6 CRG86119.1 - 3.6e-12 46.5 0.1 4.7e-12 46.1 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain Terpene_synth_C PF03936.16 CRG86121.1 - 1.1e-05 24.9 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain DUF2236 PF09995.9 CRG86122.1 - 3.8e-30 105.8 0.3 5.5e-30 105.2 0.3 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) PGPGW PF09656.10 CRG86122.1 - 0.049 13.1 1.7 0.081 12.5 0.2 2.1 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) F-box PF00646.33 CRG86123.1 - 0.0048 16.7 2.9 0.0056 16.5 0.1 2.3 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 CRG86123.1 - 0.028 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 F-box FYDLN_acid PF09538.10 CRG86123.1 - 0.055 14.2 2.2 0.12 13.0 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) F-box-like PF12937.7 CRG86123.1 - 0.1 12.5 0.5 0.22 11.4 0.5 1.6 1 0 0 1 1 1 0 F-box-like Peptidase_C14 PF00656.22 CRG86124.1 - 4.9e-59 200.3 0.0 6.8e-59 199.8 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Methyltransf_16 PF10294.9 CRG86125.1 - 1.2e-13 51.2 0.1 3.3e-13 49.8 0.1 1.6 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CRG86125.1 - 0.082 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CRG86125.1 - 0.12 11.6 0.0 0.25 10.5 0.0 1.5 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family TFIIA PF03153.13 CRG86126.1 - 2.8 7.8 26.0 3.5 7.5 26.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit API5 PF05918.11 CRG86127.1 - 5.4 5.7 6.2 7.8 5.2 6.2 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) KTI12 PF08433.10 CRG86128.1 - 4e-60 203.6 0.0 2.4e-59 201.0 0.0 2.2 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 CRG86128.1 - 0.008 16.3 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain zf-C2H2 PF00096.26 CRG86129.1 - 0.078 13.5 2.9 2.2 8.9 0.0 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type ABC_tran PF00005.27 CRG86131.1 - 3.5e-43 147.4 0.0 3.7e-21 76.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG86131.1 - 2.5e-37 129.0 27.0 9.7e-25 87.7 14.4 2.5 2 1 0 2 2 2 2 ABC transporter transmembrane region T2SSE PF00437.20 CRG86131.1 - 1.4e-08 34.1 0.3 0.0019 17.3 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_21 PF13304.6 CRG86131.1 - 3.3e-08 33.7 1.5 0.14 12.0 0.1 3.5 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG86131.1 - 3.4e-08 33.2 0.0 0.2 11.1 0.0 4.1 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG86131.1 - 1.8e-07 30.8 6.6 0.00047 19.8 0.2 3.3 4 0 0 4 4 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG86131.1 - 2.7e-07 30.7 0.5 0.024 14.5 0.1 3.0 2 0 0 2 2 2 2 RsgA GTPase FtsK_SpoIIIE PF01580.18 CRG86131.1 - 2.9e-07 30.1 0.0 0.0069 15.8 0.0 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_22 PF13401.6 CRG86131.1 - 2.2e-06 28.0 1.5 0.017 15.4 0.1 2.9 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 CRG86131.1 - 3.4e-06 27.7 0.5 0.0085 16.6 0.2 2.3 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CRG86131.1 - 3.6e-06 27.0 0.1 0.027 14.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG86131.1 - 1.7e-05 25.3 0.2 0.39 11.1 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 CRG86131.1 - 2.3e-05 23.4 2.0 0.0057 15.5 0.0 3.7 3 1 0 3 3 3 1 Predicted ATPase of the ABC class NTPase_1 PF03266.15 CRG86131.1 - 6.1e-05 23.0 2.6 0.027 14.4 0.0 3.1 3 0 0 3 3 3 1 NTPase AAA_25 PF13481.6 CRG86131.1 - 6.2e-05 22.7 0.1 0.49 9.9 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 CRG86131.1 - 6.4e-05 22.8 0.1 0.27 10.9 0.2 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 CRG86131.1 - 0.00024 21.3 0.1 0.07 13.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CRG86131.1 - 0.00042 20.3 1.3 0.36 10.7 0.1 2.9 2 0 0 2 2 2 2 NACHT domain Zeta_toxin PF06414.12 CRG86131.1 - 0.00044 19.6 0.7 0.29 10.4 0.1 3.0 3 0 0 3 3 3 1 Zeta toxin DAP3 PF10236.9 CRG86131.1 - 0.00052 19.3 3.6 1.7 7.7 0.0 3.3 3 0 0 3 3 3 2 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.19 CRG86131.1 - 0.00082 19.0 2.7 0.47 10.0 0.2 2.5 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 CRG86131.1 - 0.0013 18.9 3.5 0.9 9.6 0.3 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_30 PF13604.6 CRG86131.1 - 0.0014 18.3 0.2 0.31 10.7 0.1 2.6 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CRG86131.1 - 0.0018 18.0 0.6 2 8.1 0.1 2.8 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CRG86131.1 - 0.0031 17.4 0.4 8.9 6.1 0.0 3.2 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CRG86131.1 - 0.0061 16.9 0.1 7.3 7.0 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 CRG86131.1 - 0.012 15.1 0.2 1.1 8.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 CRG86131.1 - 0.012 15.6 1.4 3.3 7.7 0.1 2.5 2 0 0 2 2 2 0 Dynamin family NB-ARC PF00931.22 CRG86131.1 - 0.023 13.9 1.1 2.4 7.2 0.1 3.2 4 0 0 4 4 2 0 NB-ARC domain TsaE PF02367.17 CRG86131.1 - 0.054 13.5 0.1 3 7.9 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CbiA PF01656.23 CRG86131.1 - 0.062 13.3 2.6 3.4 7.7 0.1 3.3 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 CRG86131.1 - 0.078 13.5 0.3 16 6.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 CRG86131.1 - 0.1 12.4 0.2 2.6 7.8 0.0 2.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase Mg_chelatase PF01078.21 CRG86131.1 - 0.11 11.9 0.0 15 4.9 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Adeno_IVa2 PF02456.15 CRG86131.1 - 0.15 10.9 3.2 1.6 7.5 0.1 3.1 4 0 0 4 4 4 0 Adenovirus IVa2 protein Roc PF08477.13 CRG86131.1 - 0.16 12.2 0.2 11 6.3 0.1 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 CRG86131.1 - 0.19 11.7 3.7 25 4.9 0.3 3.5 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA PF00004.29 CRG86131.1 - 0.21 12.0 0.9 12 6.3 0.0 3.5 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CRG86131.1 - 0.22 10.8 2.4 16 4.7 0.0 3.7 4 0 0 4 4 4 0 KaiC Pox_A32 PF04665.12 CRG86131.1 - 0.24 10.8 1.5 1.4 8.3 0.2 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein DUF815 PF05673.13 CRG86131.1 - 0.27 10.4 0.8 4.2 6.5 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MobB PF03205.14 CRG86131.1 - 1.6 8.7 6.3 5.8 6.8 0.2 2.9 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AIG1 PF04548.16 CRG86131.1 - 4.8 6.5 5.0 36 3.6 0.2 2.9 3 0 0 3 3 3 0 AIG1 family Ion_trans_2 PF07885.16 CRG86132.1 - 5.4e-29 100.0 23.9 2.7e-17 62.5 4.5 3.0 3 0 0 3 3 3 2 Ion channel Fungal_trans PF04082.18 CRG86132.1 - 1.5e-05 24.1 0.1 3e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ion_trans PF00520.31 CRG86132.1 - 0.0046 16.2 12.6 0.084 12.1 1.7 3.3 2 1 1 3 3 3 2 Ion transport protein DUF5453 PF17534.2 CRG86132.1 - 0.18 11.8 2.1 0.17 11.9 0.4 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5453) Palm_thioest PF02089.15 CRG86133.1 - 3.6e-83 279.1 0.0 4.1e-83 278.9 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 CRG86133.1 - 0.00096 18.9 0.0 0.0018 18.0 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF915 PF06028.11 CRG86133.1 - 0.0054 16.1 0.0 0.0083 15.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_2 PF02230.16 CRG86133.1 - 0.034 13.9 0.2 2.9 7.6 0.0 2.4 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase MFS_1 PF07690.16 CRG86134.1 - 8.8e-43 146.6 52.0 8.8e-43 146.6 52.0 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86134.1 - 1.2e-12 47.4 26.0 1.9e-10 40.2 3.8 3.2 2 1 1 3 3 3 2 Sugar (and other) transporter TERB2 PF15101.6 CRG86134.1 - 0.17 12.0 0.2 3.5 7.6 0.1 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Fungal_trans PF04082.18 CRG86135.1 - 2.2e-12 46.6 0.0 4.2e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CENP-L PF13092.6 CRG86137.1 - 3.1e-41 141.3 1.2 4.7e-41 140.7 1.2 1.3 1 0 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 mRNA_decap_C PF16741.5 CRG86137.1 - 0.017 14.4 0.3 0.67 9.3 0.1 2.4 1 1 1 2 2 2 0 mRNA-decapping enzyme C-terminus Sulfate_transp PF00916.20 CRG86138.1 - 2.2e-78 263.7 13.4 3.1e-78 263.2 13.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CRG86138.1 - 1.8e-16 59.9 0.0 3.3e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 CRG86138.1 - 0.00016 22.0 0.0 0.00049 20.4 0.0 1.9 2 1 0 2 2 2 1 STAS domain MFS_MOT1 PF16983.5 CRG86138.1 - 0.0012 19.2 4.8 0.0012 19.2 4.8 2.7 3 0 0 3 3 3 1 Molybdate transporter of MFS superfamily Tenui_PVC2 PF06656.11 CRG86138.1 - 0.59 8.0 2.0 0.86 7.4 2.0 1.1 1 0 0 1 1 1 0 Tenuivirus PVC2 protein EIF_2_alpha PF07541.12 CRG86139.1 - 1.2e-38 131.7 0.1 3.1e-38 130.4 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 CRG86139.1 - 1.2e-13 51.2 0.7 2.3e-13 50.3 0.7 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Abhydrolase_1 PF00561.20 CRG86140.1 - 3.6e-29 102.2 0.0 3.2e-28 99.1 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CRG86140.1 - 1e-15 57.7 0.0 2.2e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 CRG86140.1 - 0.12 11.6 0.0 0.36 10.0 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 PKD_channel PF08016.12 CRG86141.1 - 6.7e-09 34.9 18.1 3.9e-08 32.4 18.1 2.1 1 1 0 1 1 1 1 Polycystin cation channel DUF4212 PF13937.6 CRG86141.1 - 0.019 15.3 1.0 0.019 15.3 1.0 3.5 4 1 0 4 4 4 0 Domain of unknown function (DUF4212) TssO PF17561.2 CRG86141.1 - 1.7 8.7 4.2 15 5.6 0.5 2.7 2 0 0 2 2 2 0 Type VI secretion system, TssO PNP_UDP_1 PF01048.20 CRG86142.1 - 1.4e-16 60.5 0.0 4.7e-16 58.8 0.0 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily FBPase_3 PF01950.16 CRG86142.1 - 0.2 10.8 0.0 0.39 9.8 0.0 1.4 1 0 0 1 1 1 0 Fructose-1,6-bisphosphatase PBD PF00786.28 CRG86143.1 - 8e-07 29.3 0.2 2.5e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 P21-Rho-binding domain zf-Di19 PF05605.12 CRG86143.1 - 0.021 15.1 11.8 0.07 13.4 0.5 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CRG86143.1 - 0.31 12.0 15.3 10 7.3 0.1 5.5 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG86143.1 - 9.5 6.9 9.7 1.4e+02 3.2 0.1 4.7 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG86143.1 - 9.6 6.8 7.9 35 5.0 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger double domain RTA1 PF04479.13 CRG86144.1 - 1.6e-73 246.7 10.2 1.6e-73 246.7 10.2 1.5 2 0 0 2 2 2 1 RTA1 like protein Fungal_trans_2 PF11951.8 CRG86145.1 - 4e-07 29.2 2.0 3.7e-06 26.0 2.0 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Rbsn PF11464.8 CRG86146.1 - 8.7e-18 63.8 1.2 2.2e-17 62.5 0.6 2.1 2 0 0 2 2 2 1 Rabenosyn Rab binding domain YqaH PF17448.2 CRG86146.1 - 0.0044 17.3 1.3 0.0056 17.0 0.1 1.8 2 0 0 2 2 2 1 Uncharacterized YqaH-like zf-Di19 PF05605.12 CRG86146.1 - 0.012 15.9 0.2 0.024 14.9 0.2 1.5 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 CRG86146.1 - 0.02 15.2 0.0 0.04 14.3 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) TMF_TATA_bd PF12325.8 CRG86146.1 - 0.033 14.4 4.1 0.096 12.9 0.5 2.6 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding zf-C2H2_4 PF13894.6 CRG86146.1 - 0.16 12.9 0.0 0.56 11.2 0.0 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger E1-E2_ATPase PF00122.20 CRG86147.1 - 1.3e-19 70.4 0.0 3e-19 69.2 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 CRG86147.1 - 1.3e-14 55.0 2.9 3.3e-08 34.1 2.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Acyltransferase PF01553.21 CRG86147.1 - 1e-08 34.9 0.0 1.3e-07 31.3 0.0 2.4 1 1 0 1 1 1 1 Acyltransferase Cation_ATPase PF13246.6 CRG86147.1 - 0.0014 18.7 0.0 0.037 14.1 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CRG86147.1 - 0.0044 16.8 0.1 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pih1_fungal_CS PF18482.1 CRG86147.1 - 0.14 12.7 0.4 11 6.6 0.0 2.5 2 0 0 2 2 2 0 Fungal Pih1 CS domain CFEM PF05730.11 CRG86148.1 - 3.6e-15 55.8 14.4 5.6e-15 55.2 14.4 1.3 1 0 0 1 1 1 1 CFEM domain Gamma-thionin PF00304.20 CRG86148.1 - 0.2 12.0 3.1 0.3 11.4 1.5 2.0 2 0 0 2 2 2 0 Gamma-thionin family AMP-binding PF00501.28 CRG86149.1 - 1.1e-69 235.1 0.0 1.5e-69 234.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG86149.1 - 4.8e-11 43.5 0.0 1.3e-10 42.1 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Macro PF01661.21 CRG86150.1 - 3.9e-38 130.1 0.0 5.5e-38 129.6 0.0 1.2 1 0 0 1 1 1 1 Macro domain Peptidase_S24 PF00717.23 CRG86151.1 - 2e-08 34.1 0.0 7.8e-08 32.2 0.0 2.0 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 CRG86151.1 - 0.002 17.9 0.0 0.4 10.5 0.0 2.6 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 PH_4 PF15404.6 CRG86152.1 - 1.7e-58 197.5 0.3 8.9e-56 188.6 0.3 3.7 2 1 0 2 2 2 1 Pleckstrin homology domain Spo7_2_N PF15407.6 CRG86152.1 - 3.5e-23 81.0 0.2 1e-22 79.5 0.2 1.9 1 0 0 1 1 1 1 Sporulation protein family 7 PH PF00169.29 CRG86152.1 - 6.1e-15 55.6 1.0 0.00043 20.8 0.0 5.4 4 1 0 4 4 4 4 PH domain PH_6 PF15406.6 CRG86152.1 - 0.00026 21.2 0.0 0.81 10.0 0.0 3.0 2 1 0 2 2 2 2 Pleckstrin homology domain PH_2 PF08458.10 CRG86152.1 - 0.0077 16.6 0.1 2.4 8.5 0.0 3.3 3 0 0 3 3 3 1 Plant pleckstrin homology-like region PH_13 PF16652.5 CRG86152.1 - 0.011 15.6 0.1 0.37 10.6 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 CRG86152.1 - 0.082 13.3 0.0 11 6.5 0.0 3.4 3 0 0 3 3 3 0 Pleckstrin homology domain GLTP PF08718.11 CRG86153.1 - 3.5e-44 150.7 0.0 4.5e-44 150.3 0.0 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) TssR PF17643.1 CRG86153.1 - 0.04 11.9 0.0 0.061 11.3 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssR Aminotran_1_2 PF00155.21 CRG86154.1 - 9.5e-32 110.6 0.0 9.8e-21 74.3 0.0 2.0 2 0 0 2 2 2 2 Aminotransferase class I and II Sulfatase PF00884.23 CRG86155.1 - 5.8e-58 196.7 0.0 8.9e-58 196.1 0.0 1.2 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 CRG86155.1 - 6.4e-20 71.3 3.6 2.7e-19 69.3 2.2 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4976) Zn_clus PF00172.18 CRG86155.1 - 9.8e-16 57.6 28.9 3.9e-08 33.3 12.2 2.8 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG86155.1 - 1.7e-07 30.5 0.1 3e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Phosphodiest PF01663.22 CRG86155.1 - 6.2e-06 26.0 0.5 6.7e-05 22.6 0.5 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CRG86155.1 - 0.074 11.6 0.0 0.15 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Acetyltransf_4 PF13420.7 CRG86156.1 - 4.7e-08 33.3 0.0 1.6e-06 28.3 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG86156.1 - 2.8e-06 27.5 0.0 5.4e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG86156.1 - 1.5e-05 25.3 0.0 0.00011 22.5 0.0 2.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CRG86156.1 - 0.0014 19.3 0.0 0.002 18.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG86156.1 - 0.04 13.9 0.0 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Ank_4 PF13637.6 CRG86158.1 - 3.5e-09 37.0 0.0 0.00017 22.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG86158.1 - 2.1e-08 34.6 0.0 0.0006 20.4 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 CRG86158.1 - 3.1e-08 33.7 0.3 4e-05 23.9 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 CRG86158.1 - 4.4e-08 32.8 0.3 0.00058 20.1 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 CRG86158.1 - 5.7e-06 26.5 0.3 0.00086 19.6 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) KilA-N PF04383.13 CRG86158.1 - 8.5e-06 25.6 0.2 6e-05 22.9 0.0 2.4 2 1 0 2 2 2 1 KilA-N domain NDUF_B7 PF05676.13 CRG86159.1 - 4.6e-29 99.9 6.3 7.4e-29 99.3 6.3 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GCS PF03074.16 CRG86160.1 - 7.1e-156 519.2 0.0 1.1e-155 518.6 0.0 1.2 1 0 0 1 1 1 1 Glutamate-cysteine ligase GATA PF00320.27 CRG86161.1 - 3.1e-15 55.5 5.3 5.6e-15 54.7 5.3 1.4 1 0 0 1 1 1 1 GATA zinc finger zinc_ribbon_9 PF14369.6 CRG86161.1 - 0.39 11.0 1.6 0.83 10.0 1.6 1.5 1 0 0 1 1 1 0 zinc-ribbon ThrE PF06738.12 CRG86162.1 - 3.7e-73 245.9 12.6 7.4e-68 228.5 2.6 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CRG86162.1 - 1.3e-07 31.8 10.1 1.3e-07 31.8 10.1 2.8 2 1 0 2 2 2 1 Threonine/Serine exporter, ThrE MIS13 PF08202.11 CRG86163.1 - 4.3e-50 170.7 2.7 1.1e-49 169.4 2.7 1.7 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DivIC PF04977.15 CRG86163.1 - 0.54 10.1 2.3 0.52 10.1 0.3 2.0 2 0 0 2 2 2 0 Septum formation initiator PS_Dcarbxylase PF02666.15 CRG86164.1 - 2.1e-57 194.0 0.0 3.1e-57 193.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 CRG86164.1 - 1.3e-39 134.6 0.0 1e-18 67.5 0.0 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_5 PF13202.6 CRG86164.1 - 0.027 13.9 1.3 0.04 13.4 0.0 2.0 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 CRG86164.1 - 0.054 13.1 0.0 0.18 11.4 0.0 2.0 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 CRG86164.1 - 0.11 12.5 0.0 0.42 10.7 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain MBR1 PF17058.5 CRG86164.1 - 1.4 9.2 6.3 32 4.7 3.0 2.6 3 0 0 3 3 3 0 Mitochondrial biogenesis regulation protein 1 Sugar_tr PF00083.24 CRG86165.1 - 2e-92 310.4 13.6 2.4e-92 310.2 13.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86165.1 - 3.1e-33 115.2 41.3 1.7e-23 83.2 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CRG86165.1 - 2.1e-06 27.3 2.9 2.1e-06 27.3 2.9 2.7 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 CRG86165.1 - 0.1 11.0 7.2 0.012 14.1 2.3 1.8 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CRG86165.1 - 2.4 6.3 9.4 0.1 10.9 1.9 2.4 2 1 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family Pkinase PF00069.25 CRG86166.1 - 1.9e-62 211.0 0.0 2.7e-62 210.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86166.1 - 3.9e-29 101.7 0.0 6.2e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG86166.1 - 0.0035 16.3 0.0 0.0049 15.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain zf-UBR PF02207.20 CRG86167.1 - 1.9e-13 50.3 6.0 1.9e-13 50.3 6.0 3.7 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) NPR3 PF03666.13 CRG86167.1 - 0.8 8.4 2.9 1.2 7.8 2.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 CRG86167.1 - 9.5 4.9 8.9 0.42 9.3 3.3 1.5 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 MCM PF00493.23 CRG86168.1 - 2.6e-101 337.4 0.0 3.9e-101 336.8 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CRG86168.1 - 1.2e-38 131.8 0.3 2.7e-38 130.7 0.3 1.6 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 CRG86168.1 - 3.5e-28 98.8 40.2 3.5e-28 98.8 40.2 2.2 2 0 0 2 2 2 1 Mini-chromosome maintenance protein 2 MCM_lid PF17855.1 CRG86168.1 - 1.9e-24 85.9 1.5 4.8e-24 84.6 0.7 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 CRG86168.1 - 3.6e-11 43.6 0.0 1.1e-10 42.1 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CRG86168.1 - 1.6e-08 34.2 0.1 2.5e-06 27.0 0.0 2.5 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CRG86168.1 - 8.3e-06 25.8 0.0 2.3e-05 24.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CRG86168.1 - 0.00013 21.9 0.0 0.00063 19.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CRG86168.1 - 0.0031 17.2 0.1 0.021 14.5 0.1 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain DUF3659 PF12396.8 CRG86168.1 - 0.032 14.2 0.0 0.12 12.4 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3659) AAA_16 PF13191.6 CRG86168.1 - 0.065 13.6 0.0 0.35 11.2 0.0 2.3 1 0 0 1 1 1 0 AAA ATPase domain DUF3987 PF13148.6 CRG86168.1 - 1.2 8.1 5.0 8.9 5.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) F-box-like PF12937.7 CRG86169.1 - 0.00065 19.6 0.1 0.00065 19.6 0.1 2.7 3 1 0 3 3 3 1 F-box-like BRICHOS PF04089.14 CRG86169.1 - 0.055 13.7 0.1 0.14 12.4 0.0 1.7 2 0 0 2 2 2 0 BRICHOS domain DUF4571 PF15137.6 CRG86169.1 - 0.093 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4571) Sugar_tr PF00083.24 CRG86170.1 - 9.3e-117 390.6 29.3 1.1e-116 390.4 29.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86170.1 - 1e-23 83.9 34.0 1.7e-21 76.6 26.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Melibiase_2 PF16499.5 CRG86171.1 - 6.6e-63 212.5 7.2 6.1e-47 160.1 3.1 2.2 2 0 0 2 2 2 2 Alpha galactosidase A MFS_1 PF07690.16 CRG86171.1 - 5.8e-31 107.7 16.6 5.8e-31 107.7 16.6 2.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Melibiase_C PF17801.1 CRG86171.1 - 6.3e-11 42.2 0.9 7.8e-08 32.3 0.4 2.6 2 0 0 2 2 2 2 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 CRG86171.1 - 3.6e-07 29.5 0.1 1.1e-06 27.8 0.0 1.7 2 0 0 2 2 2 1 Melibiase Sugar_tr PF00083.24 CRG86171.1 - 4.5e-06 25.8 11.6 0.00058 18.8 0.0 3.2 3 0 0 3 3 3 2 Sugar (and other) transporter SKG6 PF08693.10 CRG86172.1 - 0.00016 21.0 0.5 0.00039 19.8 0.5 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4448 PF14610.6 CRG86172.1 - 0.0039 17.0 0.0 0.0052 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SSP160 PF06933.11 CRG86172.1 - 0.0084 14.4 8.3 0.0095 14.2 8.3 1.0 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 MGC-24 PF05283.11 CRG86172.1 - 0.0096 16.4 6.2 0.015 15.7 6.2 1.3 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin PTP_tm PF18861.1 CRG86172.1 - 0.063 13.3 0.0 0.087 12.8 0.0 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Mucin PF01456.17 CRG86172.1 - 0.39 10.7 19.7 0.64 10.0 19.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Alpha_GJ PF03229.13 CRG86172.1 - 0.93 10.1 13.9 1.8 9.2 13.9 1.5 1 0 0 1 1 1 0 Alphavirus glycoprotein J PAN_4 PF14295.6 CRG86173.1 - 0.027 14.4 2.7 0.061 13.2 2.7 1.6 1 0 0 1 1 1 0 PAN domain Fringe PF02434.16 CRG86173.1 - 0.057 12.8 0.5 0.69 9.3 0.5 2.1 1 1 0 1 1 1 0 Fringe-like DUF604 PF04646.12 CRG86173.1 - 0.11 11.9 0.0 0.24 10.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF604 DUF829 PF05705.14 CRG86174.1 - 9e-45 153.4 0.0 1e-44 153.2 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) CorA PF01544.18 CRG86175.1 - 1.3e-08 34.6 0.1 1.8e-08 34.1 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DDE_Tnp_ISL3 PF01610.17 CRG86175.1 - 0.082 12.6 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Transposase WH1 PF00568.23 CRG86176.1 - 2.1e-25 88.8 0.0 2.8e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 CRG86176.1 - 0.064 13.1 5.4 0.29 11.0 5.4 2.1 1 1 0 1 1 1 0 WH2 motif ERCC4 PF02732.15 CRG86177.1 - 8.6e-20 71.5 0.0 1.9e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 ERCC4 domain DUF4780 PF16012.5 CRG86177.1 - 0.0053 16.2 0.0 13 5.2 0.0 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4780) YjcZ PF13990.6 CRG86177.1 - 0.17 11.2 0.1 0.31 10.4 0.1 1.3 1 0 0 1 1 1 0 YjcZ-like protein eIF-1a PF01176.19 CRG86178.1 - 9e-23 79.9 0.1 1.3e-22 79.4 0.1 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 GntR PF00392.21 CRG86179.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family fn3_2 PF16893.5 CRG86180.1 - 5.6e-38 129.0 0.1 1e-37 128.1 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 CRG86180.1 - 2.3e-24 85.1 0.4 4.5e-24 84.1 0.4 1.5 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 CRG86180.1 - 7.5e-13 48.2 0.0 1.3e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 CRG86180.1 - 6.6e-08 32.8 0.0 1.2e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CRG86180.1 - 8.2e-06 26.1 0.0 1.7e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain DUF3006 PF11213.8 CRG86180.1 - 9.3e-05 22.6 0.1 0.00048 20.3 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3006) fn3 PF00041.21 CRG86180.1 - 0.0086 16.4 1.6 0.035 14.4 0.0 2.7 2 1 0 2 2 2 1 Fibronectin type III domain DUF3784 PF12650.7 CRG86181.1 - 0.011 15.9 0.0 0.014 15.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) DUF3500 PF12006.8 CRG86182.1 - 1e-110 369.9 0.0 1.2e-110 369.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3500) DUF3439 PF11921.8 CRG86183.1 - 0.35 10.8 4.5 0.9 9.5 4.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SEN1_N PF12726.7 CRG86184.1 - 4.7e-202 673.2 0.5 6.2e-202 672.8 0.5 1.1 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 CRG86184.1 - 3e-71 240.3 1.2 3e-71 240.3 1.2 2.5 3 0 0 3 3 3 1 AAA domain AAA_12 PF13087.6 CRG86184.1 - 2.5e-60 203.5 0.0 5.3e-60 202.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG86184.1 - 2.6e-09 37.1 0.1 2.7e-05 24.0 0.1 2.6 2 0 0 2 2 2 2 AAA domain UvrD-helicase PF00580.21 CRG86184.1 - 5.9e-07 29.3 3.2 1.2e-05 25.0 0.4 3.4 3 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 CRG86184.1 - 6.1e-07 29.9 0.0 2.4e-06 27.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CRG86184.1 - 1.2e-06 28.5 3.3 0.022 14.5 0.0 4.0 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 CRG86184.1 - 0.0033 17.2 0.2 0.0093 15.7 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase T2SSE PF00437.20 CRG86184.1 - 0.091 11.8 0.0 0.2 10.7 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 CRG86184.1 - 0.65 10.5 3.8 0.94 9.9 0.3 3.0 4 0 0 4 4 4 0 AAA domain PhoLip_ATPase_C PF16212.5 CRG86185.1 - 2.4e-80 269.9 20.9 2.4e-80 269.9 20.9 2.1 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CRG86185.1 - 1.8e-19 69.2 0.3 4.5e-19 67.9 0.3 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CRG86185.1 - 4.3e-12 46.0 0.0 1.8e-11 44.0 0.0 1.9 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG86185.1 - 6.1e-11 43.0 2.5 8.1e-07 29.5 0.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CRG86185.1 - 4.6e-06 26.3 0.0 2.4e-05 23.9 0.0 2.2 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CRG86185.1 - 0.012 15.4 0.5 0.023 14.4 0.5 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase vATP-synt_E PF01991.18 CRG86187.1 - 3.6e-61 206.1 7.7 4.1e-61 205.9 7.7 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit Med3 PF11593.8 CRG86187.1 - 0.0027 17.0 0.2 0.0034 16.7 0.2 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Mg_trans_NIPA PF05653.14 CRG86188.1 - 4e-13 49.2 11.5 4.7e-08 32.5 2.9 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CRG86188.1 - 4.3e-05 23.7 1.4 4.3e-05 23.7 1.4 2.9 2 1 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 CRG86188.1 - 0.0027 17.0 2.7 0.0027 17.0 2.7 2.2 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport Multi_Drug_Res PF00893.19 CRG86188.1 - 0.27 11.9 8.0 6.8 7.4 1.2 3.1 2 1 1 3 3 3 0 Small Multidrug Resistance protein DMT_6 PF04342.12 CRG86188.1 - 2 8.7 5.5 0.64 10.2 0.6 2.3 2 0 0 2 2 2 0 Putative member of DMT superfamily (DUF486) PMP1_2 PF08114.11 CRG86188.1 - 4.4 7.1 6.0 5.4 6.8 0.1 3.5 3 0 0 3 3 3 0 ATPase proteolipid family Neurensin PF14927.6 CRG86188.1 - 7.2 6.3 9.8 8.5 6.1 1.9 3.4 3 1 0 3 3 3 0 Neurensin PHO4 PF01384.20 CRG86188.1 - 9.5 5.2 10.3 1e+02 1.8 10.1 2.4 1 1 1 2 2 2 0 Phosphate transporter family SRF-TF PF00319.18 CRG86189.1 - 3.5e-21 74.4 0.1 5.1e-21 73.9 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF3245 PF11595.8 CRG86189.1 - 2.5 8.6 8.2 0.25 11.8 2.4 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3245) Tetraspanin PF00335.20 CRG86190.1 - 9.7e-05 22.2 11.7 0.00025 20.8 11.7 1.9 1 1 0 1 1 1 1 Tetraspanin family Peptidase_U4 PF03419.13 CRG86190.1 - 3.1 7.0 8.1 4.1 6.6 4.1 2.2 2 1 0 2 2 2 0 Sporulation factor SpoIIGA Zn_clus PF00172.18 CRG86191.1 - 7.7e-09 35.5 12.4 7.7e-09 35.5 12.4 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG86191.1 - 4.2e-05 22.7 0.0 0.00097 18.2 0.0 2.4 1 1 2 3 3 3 1 Fungal specific transcription factor domain DUF604 PF04646.12 CRG86192.1 - 4.8e-08 32.7 0.0 7.3e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF604 Fringe PF02434.16 CRG86192.1 - 8.8e-06 25.3 0.1 2.5e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 Fringe-like GDI PF00996.18 CRG86193.1 - 3.6e-23 81.8 0.0 7.7e-22 77.4 0.0 2.2 1 1 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 CRG86193.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pro_isomerase PF00160.21 CRG86194.1 - 4.8e-54 182.9 0.0 5.8e-54 182.6 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3830 PF12903.7 CRG86194.1 - 0.17 11.6 0.0 0.35 10.6 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3830) Peptidase_A22B PF04258.13 CRG86195.1 - 1.6e-61 208.3 3.0 4.1e-61 207.0 3.0 1.6 1 1 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 CRG86195.1 - 8.5e-06 25.4 1.9 8.5e-06 25.4 1.9 2.0 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease FAM176 PF14851.6 CRG86195.1 - 0.94 9.1 0.0 0.94 9.1 0.0 3.3 2 1 0 2 2 2 0 FAM176 family RNase_PH PF01138.21 CRG86196.1 - 9e-16 58.6 0.0 5.7e-15 56.0 0.0 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 NAD_binding_6 PF08030.12 CRG86197.1 - 6.3e-21 75.1 0.0 1.6e-20 73.8 0.0 1.7 2 1 0 2 2 2 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CRG86197.1 - 4.9e-19 68.7 9.9 1.3e-18 67.3 9.9 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CRG86197.1 - 4.6e-12 46.0 0.0 1.9e-11 44.0 0.0 2.0 2 1 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 CRG86197.1 - 0.00021 21.9 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 CRG86197.1 - 0.052 14.1 11.0 0.37 11.4 1.2 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) Acetyltransf_1 PF00583.25 CRG86198.1 - 0.011 15.9 0.1 0.18 12.1 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Nitr_red_bet_C PF14711.6 CRG86198.1 - 0.12 12.0 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Respiratory nitrate reductase beta C-terminal RRN3 PF05327.11 CRG86198.1 - 0.39 9.2 5.6 0.5 8.8 5.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LRS4 PF10422.9 CRG86198.1 - 3.5 7.1 9.3 0.059 12.9 0.4 2.3 2 1 0 2 2 2 0 Monopolin complex subunit LRS4 Sgf11 PF08209.11 CRG86199.1 - 3.9e-11 42.3 0.2 3.9e-11 42.3 0.2 2.2 3 0 0 3 3 3 1 Sgf11 (transcriptional regulation protein) PRA-PH PF01503.17 CRG86199.1 - 0.0088 16.5 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase zf-ribbon_3 PF13248.6 CRG86199.1 - 0.063 12.7 4.0 1.1 8.7 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon domain TRAF6_Z2 PF18048.1 CRG86199.1 - 0.11 12.6 0.3 0.11 12.6 0.3 1.7 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2HC5 PF06221.13 CRG86200.1 - 1.4e-20 73.0 7.6 2.2e-20 72.4 7.6 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type p450 PF00067.22 CRG86201.1 - 8.8e-70 235.7 0.0 1.1e-69 235.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Mpv17_PMP22 PF04117.12 CRG86202.1 - 2.4e-11 43.7 2.2 3.3e-11 43.3 0.1 2.2 2 0 0 2 2 2 1 Mpv17 / PMP22 family Hexokinase_2 PF03727.16 CRG86203.1 - 3.6e-75 252.5 0.0 4.7e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CRG86203.1 - 9.4e-75 250.9 0.0 1.5e-74 250.2 0.0 1.4 1 0 0 1 1 1 1 Hexokinase PARP PF00644.20 CRG86204.1 - 7.2e-61 205.2 0.0 1.4e-60 204.3 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 CRG86204.1 - 5.5e-41 139.9 0.1 9.3e-41 139.1 0.1 1.4 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain WGR PF05406.15 CRG86204.1 - 5.8e-24 84.0 1.0 1.2e-23 82.9 0.5 1.8 2 0 0 2 2 2 1 WGR domain BRCT PF00533.26 CRG86204.1 - 1.3e-11 44.7 0.0 5e-11 42.8 0.0 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 CRG86204.1 - 1.1e-06 28.4 0.1 2.5e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 CRG86204.1 - 6.3e-05 23.3 0.0 0.00015 22.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain F-box PF00646.33 CRG86205.1 - 0.00034 20.4 0.4 0.0014 18.4 0.4 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG86205.1 - 0.0026 17.6 0.2 0.007 16.2 0.2 1.7 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 CRG86205.1 - 0.013 15.9 2.5 40 4.8 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) Aldo_ket_red PF00248.21 CRG86206.1 - 2.4e-72 243.6 0.0 2.7e-72 243.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family adh_short PF00106.25 CRG86207.1 - 6.5e-29 100.8 0.0 9.3e-29 100.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86207.1 - 9.6e-20 71.1 0.0 1.3e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86207.1 - 8.8e-06 25.7 0.1 3.7e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CRG86207.1 - 6.6e-05 22.5 0.1 9.4e-05 22.0 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CRG86207.1 - 0.00094 19.3 0.0 0.0022 18.1 0.0 1.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SAF PF08666.12 CRG86207.1 - 0.14 12.8 0.0 0.34 11.6 0.0 1.6 1 0 0 1 1 1 0 SAF domain DUF3425 PF11905.8 CRG86208.1 - 2.9e-22 79.0 0.6 5.4e-22 78.1 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CRG86208.1 - 0.011 15.9 8.7 0.019 15.0 8.7 1.4 1 0 0 1 1 1 0 bZIP transcription factor Abhydrolase_6 PF12697.7 CRG86209.1 - 1.3e-05 25.9 0.3 0.00022 21.9 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 CRG86209.1 - 0.00012 21.7 0.0 0.00069 19.2 0.0 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 CRG86209.1 - 0.00021 21.0 0.1 0.00029 20.5 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 CRG86209.1 - 0.015 14.0 0.2 0.12 11.0 0.0 2.0 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) DUF1100 PF06500.11 CRG86209.1 - 0.02 13.7 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) NmrA PF05368.13 CRG86210.1 - 3.1e-32 112.0 0.0 2.9e-28 99.0 0.0 2.2 1 1 1 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 CRG86210.1 - 3.6e-10 40.1 0.0 1.8e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG86210.1 - 5.1e-07 29.0 0.0 7.2e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG86210.1 - 1.1e-05 25.0 0.1 1.8e-05 24.4 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CRG86210.1 - 0.087 11.9 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GARS_C PF02843.16 CRG86210.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, C domain GDP_Man_Dehyd PF16363.5 CRG86210.1 - 0.18 11.2 0.2 0.29 10.5 0.0 1.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Fungal_trans PF04082.18 CRG86211.1 - 2.1e-17 63.0 0.0 3.1e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain GWT1 PF06423.12 CRG86211.1 - 0.072 13.2 0.1 0.15 12.2 0.1 1.6 1 0 0 1 1 1 0 GWT1 F420_oxidored PF03807.17 CRG86212.1 - 1e-09 38.9 0.0 1.5e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 CRG86212.1 - 5.6e-07 29.5 0.0 2.6e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 Rossmann-like domain Epimerase PF01370.21 CRG86213.1 - 5.4e-17 62.1 0.0 1.1e-16 61.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG86213.1 - 2e-14 53.3 0.0 7e-14 51.5 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG86213.1 - 5.4e-11 42.5 0.0 8.1e-10 38.6 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG86213.1 - 1.3e-10 40.9 0.2 2e-06 27.2 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 CRG86213.1 - 1.5e-09 38.0 0.1 2.8e-09 37.1 0.0 1.5 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 CRG86213.1 - 1.1e-06 28.5 0.0 1.8e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CRG86213.1 - 2.8e-05 23.4 0.0 5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CRG86213.1 - 0.00042 19.5 0.0 0.38 9.8 0.0 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain adh_short PF00106.25 CRG86213.1 - 0.047 13.1 0.0 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 short chain dehydrogenase KR PF08659.10 CRG86213.1 - 0.18 11.7 0.2 15 5.5 0.0 2.5 2 1 0 2 2 2 0 KR domain Pkinase PF00069.25 CRG86214.1 - 2.8e-21 76.1 0.0 5e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86214.1 - 2.3e-16 59.9 0.0 5e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_4 PF13637.6 CRG86214.1 - 1.9e-07 31.5 0.0 0.00047 20.7 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG86214.1 - 0.007 16.7 0.1 0.026 14.8 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Kdo PF06293.14 CRG86214.1 - 0.034 13.5 0.0 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.7 CRG86214.1 - 0.16 12.6 0.0 0.67 10.6 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) HeLo PF14479.6 CRG86215.1 - 0.00068 19.5 0.2 0.0013 18.7 0.2 1.4 1 0 0 1 1 1 1 Prion-inhibition and propagation Pkinase PF00069.25 CRG86215.1 - 0.031 13.7 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF1690 PF07956.11 CRG86216.1 - 8.5e-39 133.2 6.3 7.7e-19 68.5 1.2 2.0 2 0 0 2 2 2 2 Protein of Unknown function (DUF1690) RPW8 PF05659.11 CRG86216.1 - 0.025 14.3 0.8 0.025 14.3 0.8 1.8 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 PET117 PF15786.5 CRG86216.1 - 0.029 14.6 0.4 0.029 14.6 0.4 2.1 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial eIF3_N PF09440.10 CRG86216.1 - 0.035 14.5 1.4 0.7 10.3 0.1 2.2 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain Rootletin PF15035.6 CRG86216.1 - 0.048 13.7 4.9 0.1 12.6 0.7 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Apolipoprotein PF01442.18 CRG86216.1 - 0.061 13.2 6.6 0.38 10.6 2.7 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Phasin PF05597.11 CRG86216.1 - 0.089 12.8 3.6 0.9 9.6 0.3 2.2 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) HSCB_C PF07743.13 CRG86216.1 - 2 8.9 7.3 0.78 10.3 0.9 2.7 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain POP1 PF06978.11 CRG86217.1 - 2e-73 246.8 15.6 2e-73 246.8 15.6 2.0 3 0 0 3 3 3 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 CRG86217.1 - 1.7e-32 111.6 0.4 9.5e-32 109.2 0.4 2.4 1 0 0 1 1 1 1 POPLD (NUC188) domain Dus PF01207.17 CRG86217.1 - 0.16 11.1 2.2 0.26 10.3 2.2 1.2 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Redoxin PF08534.10 CRG86218.1 - 5.7e-35 120.2 0.0 6.2e-35 120.1 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CRG86218.1 - 7.7e-12 45.2 0.0 9.9e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Stirrup PF09061.6 CRG86218.1 - 0.07 13.3 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 2 0 Stirrup Pkinase PF00069.25 CRG86219.1 - 7.1e-67 225.6 0.0 8.5e-66 222.0 0.0 2.5 2 1 0 2 2 2 1 Protein kinase domain DUF1348 PF07080.11 CRG86219.1 - 4.2e-55 185.2 4.3 1.3e-54 183.6 4.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1348) Fungal_KA1 PF16797.5 CRG86219.1 - 1.2e-40 137.9 1.7 1.7e-40 137.4 0.4 2.0 2 0 0 2 2 2 1 Fungal kinase associated-1 domain Pkinase_Tyr PF07714.17 CRG86219.1 - 3e-35 121.7 0.0 3.6e-33 114.9 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase SnoaL_2 PF12680.7 CRG86219.1 - 1.1e-05 26.0 0.1 3.1e-05 24.6 0.1 1.9 1 0 0 1 1 1 1 SnoaL-like domain Haspin_kinase PF12330.8 CRG86219.1 - 0.00073 18.6 1.2 0.00082 18.4 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CRG86219.1 - 0.00077 19.5 0.0 0.18 11.7 0.1 3.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG86219.1 - 0.0034 16.8 0.0 0.0075 15.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CRG86219.1 - 0.0097 15.3 0.0 0.021 14.1 0.0 1.6 1 0 0 1 1 1 1 Kinase-like DUF4440 PF14534.6 CRG86219.1 - 0.0099 16.3 0.1 0.042 14.3 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4440) Choline_kinase PF01633.20 CRG86219.1 - 0.043 13.4 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase SnoaL PF07366.12 CRG86219.1 - 0.18 11.6 0.1 0.51 10.2 0.1 1.8 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase Zn_clus PF00172.18 CRG86220.1 - 2.1e-08 34.2 6.8 3e-08 33.6 6.8 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2461 PF09365.10 CRG86221.1 - 1.6e-80 270.0 0.0 2.1e-80 269.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Presenilin PF01080.17 CRG86221.1 - 0.91 8.2 10.8 1.3 7.7 10.8 1.1 1 0 0 1 1 1 0 Presenilin Ehrlichia_rpt PF09528.10 CRG86221.1 - 1.9 8.0 5.7 15 5.2 2.3 2.5 2 0 0 2 2 2 0 Ehrlichia tandem repeat (Ehrlichia_rpt) Apt1 PF10351.9 CRG86221.1 - 4.9 5.9 8.7 6.2 5.5 8.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain TYW3 PF02676.14 CRG86222.1 - 1.7e-74 249.8 0.0 2.2e-74 249.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 ARPC4 PF05856.12 CRG86223.1 - 3.7e-76 254.4 3.5 7.7e-76 253.3 3.5 1.6 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) RRM_1 PF00076.22 CRG86223.1 - 0.0017 18.1 0.0 0.0087 15.9 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UCH PF00443.29 CRG86224.1 - 2.4e-51 174.7 0.0 3.2e-51 174.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG86224.1 - 5.3e-12 46.0 7.3 4.5e-11 42.9 7.3 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 CRG86224.1 - 2.7e-10 39.9 0.0 9.6e-10 38.1 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin family Peptidase_C98 PF15499.6 CRG86224.1 - 0.0035 16.9 0.3 0.39 10.1 0.2 3.1 4 0 0 4 4 4 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase RNA_pol_3_Rpc31 PF11705.8 CRG86224.1 - 8.4 6.6 16.7 2.4 8.3 11.9 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 4HBT PF03061.22 CRG86225.1 - 1.7e-06 28.3 0.1 3.2e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily TRI12 PF06609.13 CRG86226.1 - 3.5e-35 121.5 27.9 4.3e-35 121.2 27.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CRG86226.1 - 7.3e-18 64.6 48.0 7.3e-18 64.6 48.0 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86226.1 - 2.1e-10 40.1 13.6 2.1e-10 40.1 13.6 3.1 3 1 1 4 4 4 2 Sugar (and other) transporter WD40 PF00400.32 CRG86227.1 - 9.7e-08 32.6 23.1 0.0014 19.4 0.0 7.3 7 0 0 7 7 7 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 CRG86227.1 - 8.5e-07 28.5 15.7 8.5e-07 28.5 15.7 2.2 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 CRG86227.1 - 0.0033 17.7 0.0 0.0076 16.5 0.0 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_14 PF17978.1 CRG86227.1 - 0.84 10.1 7.4 1.7 9.1 7.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.21 CRG86227.1 - 1.5 9.1 14.3 1.1 9.5 8.3 2.9 3 0 0 3 3 3 0 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 CRG86227.1 - 8 6.9 21.0 0.12 12.7 11.3 2.5 2 0 0 2 2 2 0 Ring finger domain UQ_con PF00179.26 CRG86228.1 - 4.8e-47 159.1 0.0 5.4e-47 159.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CRG86228.1 - 0.0039 16.9 0.0 0.0051 16.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 CRG86228.1 - 0.026 14.4 0.0 0.05 13.5 0.0 1.5 1 1 0 1 1 1 0 UEV domain Ribosomal_L24e PF01246.20 CRG86229.1 - 1.1e-28 99.3 0.1 1.1e-28 99.3 0.1 1.8 2 0 0 2 2 2 1 Ribosomal protein L24e DUF775 PF05603.12 CRG86229.1 - 0.34 10.4 2.6 0.45 10.0 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Acetyltransf_1 PF00583.25 CRG86230.1 - 2.7e-10 40.5 0.1 3.6e-10 40.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG86230.1 - 2.8e-08 33.7 0.0 4.2e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG86230.1 - 2.6e-07 31.0 0.3 3.9e-07 30.4 0.3 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Lyase_1 PF00206.20 CRG86231.1 - 5.7e-111 370.8 0.0 8.9e-111 370.2 0.0 1.3 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 CRG86231.1 - 4.2e-21 75.1 0.0 9.9e-21 73.9 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus Aminotran_1_2 PF00155.21 CRG86232.1 - 2e-73 247.7 0.0 2.3e-73 247.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Chorismate_bind PF00425.18 CRG86233.1 - 3.9e-63 213.4 0.0 6.4e-63 212.7 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 CRG86233.1 - 6.8e-28 97.7 0.0 4.6e-27 95.0 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 CRG86233.1 - 1e-13 51.7 0.0 2.5e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 CRG86233.1 - 0.0095 15.7 0.7 0.53 10.0 0.0 2.5 2 0 0 2 2 2 1 Peptidase C26 Sugar_tr PF00083.24 CRG86234.1 - 1.6e-28 99.8 23.2 4.9e-22 78.4 13.3 2.9 1 1 1 2 2 2 2 Sugar (and other) transporter DUF3684 PF12449.8 CRG86235.1 - 0 1409.7 0.0 0 1409.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 CRG86235.1 - 0.0012 18.7 0.0 0.0033 17.3 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UPF0767 PF15990.5 CRG86235.1 - 1.6 8.9 3.5 22 5.3 3.3 2.5 2 0 0 2 2 2 0 UPF0767 family TRAPPC9-Trs120 PF08626.11 CRG86236.1 - 0 1446.3 0.0 0 1446.1 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit fn3_5 PF06280.12 CRG86236.1 - 0.031 14.9 0.1 0.79 10.4 0.0 3.0 3 0 0 3 3 3 0 Fn3-like domain PAC3 PF10178.9 CRG86237.1 - 4.1e-05 23.7 0.0 5.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 HA2 PF04408.23 CRG86238.1 - 1.8e-26 92.5 0.0 1.8e-26 92.5 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CRG86238.1 - 1.2e-12 48.2 0.1 1e-11 45.2 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CRG86238.1 - 1.2e-09 38.4 0.0 2.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 CRG86238.1 - 1.2e-09 38.1 0.0 1.8e-08 34.3 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG86238.1 - 9.3e-06 25.7 6.7 0.0026 17.8 0.1 3.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 CRG86238.1 - 0.00035 20.9 0.1 0.0022 18.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CRG86238.1 - 0.0027 16.8 0.5 0.032 13.3 0.0 2.2 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_30 PF13604.6 CRG86238.1 - 0.0091 15.7 0.0 0.029 14.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG86238.1 - 0.011 16.1 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CRG86238.1 - 0.053 14.0 0.0 0.053 14.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 CRG86238.1 - 0.059 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family HOOK PF05622.12 CRG86238.1 - 0.15 10.2 12.3 0.25 9.5 12.3 1.3 1 0 0 1 1 1 0 HOOK protein cwf21 PF08312.12 CRG86239.1 - 1.1e-18 67.0 15.7 2.8e-18 65.8 15.7 1.7 1 0 0 1 1 1 1 cwf21 domain MmgE_PrpD PF03972.14 CRG86239.1 - 0.016 13.8 1.5 0.022 13.3 1.5 1.1 1 0 0 1 1 1 0 MmgE/PrpD family DUF4407 PF14362.6 CRG86239.1 - 6.7 6.0 6.5 8.8 5.6 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PUF PF00806.19 CRG86240.1 - 2.8e-66 215.7 11.3 1.6e-09 36.9 0.3 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat sCache_2 PF17200.4 CRG86240.1 - 0.088 12.7 2.5 16 5.3 0.0 4.3 5 0 0 5 5 5 0 Single Cache domain 2 DUF234 PF03008.14 CRG86240.1 - 0.89 10.1 3.0 0.78 10.2 0.1 2.4 4 0 0 4 4 4 0 Archaea bacterial proteins of unknown function Phosphodiest PF01663.22 CRG86242.1 - 1.1e-14 54.8 0.5 1.7e-14 54.2 0.5 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 CRG86242.1 - 2.6e-07 30.3 0.5 4.6e-07 29.4 0.5 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 CRG86242.1 - 4.2e-06 26.4 0.2 1.2e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 Sulfatase PglZ PF08665.12 CRG86242.1 - 0.078 13.1 0.9 0.92 9.6 0.2 2.4 2 0 0 2 2 2 0 PglZ domain Deltameth_res PF16020.5 CRG86242.1 - 0.3 11.0 2.4 0.56 10.1 0.3 2.6 2 0 0 2 2 2 0 Deltamethrin resistance DUF1516 PF07457.11 CRG86242.1 - 4.6 7.5 7.5 1.7 8.9 0.3 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1516) DUF3384 PF11864.8 CRG86243.1 - 3e-89 300.2 5.6 3e-89 300.2 5.6 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 CRG86243.1 - 1.8e-49 167.9 0.0 2.9e-49 167.2 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 CRG86243.1 - 5.5e-34 117.8 0.2 2.4e-28 99.3 0.0 3.5 4 0 0 4 4 4 3 Tuberin Methyltransf_11 PF08241.12 CRG86243.1 - 0.01 16.5 0.0 0.077 13.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain CAS_CSE1 PF03378.15 CRG86244.1 - 5.4e-200 664.5 0.2 3.2e-199 662.0 0.0 2.2 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 CRG86244.1 - 6.7e-156 518.8 4.5 9.9e-156 518.2 4.5 1.3 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 CRG86244.1 - 1.2e-16 60.3 0.2 7.9e-16 57.7 0.0 2.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain DUF4420 PF14390.6 CRG86244.1 - 0.041 13.1 0.0 2.7 7.2 0.0 2.3 2 0 0 2 2 2 0 Putative PD-(D/E)XK family member, (DUF4420) DUF87 PF01935.17 CRG86244.1 - 0.15 12.2 0.5 0.77 9.8 0.2 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain RF-1 PF00472.20 CRG86245.1 - 2e-24 85.7 8.2 3.6e-24 84.9 8.2 1.3 1 0 0 1 1 1 1 RF-1 domain ORC6 PF05460.13 CRG86245.1 - 4.6 6.4 12.1 0.85 8.8 9.0 1.4 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) SPT_ssu-like PF11779.8 CRG86246.1 - 2.1e-22 78.5 2.7 3.1e-22 78.0 2.7 1.3 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like Pet100 PF09803.9 CRG86247.1 - 7.7e-21 74.4 0.2 9.7e-21 74.1 0.2 1.1 1 0 0 1 1 1 1 Pet100 ECH_1 PF00378.20 CRG86248.1 - 1.7e-26 93.1 0.0 4.4e-26 91.7 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG86248.1 - 4.3e-17 62.6 0.0 5e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase D123 PF07065.14 CRG86249.1 - 1.8e-116 388.6 0.7 1.8e-116 388.6 0.7 1.3 2 0 0 2 2 2 1 D123 DUF1640 PF07798.11 CRG86250.1 - 2e-35 122.4 3.9 2e-35 122.4 3.9 3.0 4 0 0 4 4 4 1 Protein of unknown function (DUF1640) Vps51 PF08700.11 CRG86250.1 - 3.6e-14 52.6 0.1 3e-13 49.7 0.1 2.6 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 CRG86250.1 - 0.0003 19.6 4.2 0.00062 18.5 0.7 2.9 4 0 0 4 4 4 1 Dor1-like family Glyco_hyd_65N_2 PF14498.6 CRG86250.1 - 0.033 14.0 0.8 0.093 12.6 0.8 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain HEAT_2 PF13646.6 CRG86252.1 - 1.1e-09 38.6 4.7 0.19 12.1 0.0 7.8 7 1 1 8 8 8 3 HEAT repeats HEAT PF02985.22 CRG86252.1 - 1.5e-07 31.1 19.3 1.5 9.2 0.0 9.9 11 0 0 11 11 11 4 HEAT repeat HEAT_EZ PF13513.6 CRG86252.1 - 8.5e-07 29.4 16.6 0.021 15.3 0.4 9.0 9 0 0 9 9 9 1 HEAT-like repeat Cnd1 PF12717.7 CRG86252.1 - 0.00087 19.4 0.2 3 7.9 0.0 4.8 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 CRG86252.1 - 0.038 14.0 3.5 13 6.0 0.0 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Transcrip_reg PF01709.20 CRG86253.1 - 1.7e-70 237.2 1.0 1.9e-70 237.0 1.0 1.0 1 0 0 1 1 1 1 Transcriptional regulator CENP-I PF07778.11 CRG86254.1 - 3.9e-40 138.0 0.0 1.9e-39 135.8 0.0 1.8 1 1 0 1 1 1 1 Mis6 FANCF PF11107.8 CRG86254.1 - 0.015 14.6 0.1 2.7 7.1 0.0 2.3 2 0 0 2 2 2 0 Fanconi anemia group F protein (FANCF) CLPTM1 PF05602.12 CRG86255.1 - 1e-165 552.0 0.3 1.2e-165 551.7 0.3 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) adh_short PF00106.25 CRG86256.1 - 3.8e-24 85.2 0.0 1.3e-23 83.5 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86256.1 - 3.8e-17 62.6 0.0 5.9e-17 62.0 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ASXH PF13919.6 CRG86257.1 - 2.1e-39 134.7 0.5 6.3e-39 133.2 0.5 1.9 1 0 0 1 1 1 1 Asx homology domain Longin PF13774.6 CRG86258.1 - 2.7e-26 91.4 1.0 4.5e-26 90.7 1.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 CRG86258.1 - 7.9e-14 51.2 0.0 1.6e-13 50.2 0.0 1.5 2 0 0 2 2 2 1 Synaptobrevin SLM4 PF16818.5 CRG86258.1 - 0.0014 18.6 0.2 0.065 13.2 0.0 2.1 1 1 1 2 2 2 2 Protein SLM4 Elong_Iki1 PF10483.9 CRG86259.1 - 7e-104 347.5 0.0 8.1e-104 347.3 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 PIG-L PF02585.17 CRG86261.1 - 7.3e-23 81.6 0.1 9.8e-23 81.2 0.1 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Gly_transf_sug PF04488.15 CRG86262.1 - 2.3e-11 44.1 0.0 4.8e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Gly_transf_sug PF04488.15 CRG86263.1 - 3e-09 37.4 0.0 5.8e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif tRNA-synt_1c PF00749.21 CRG86264.1 - 2e-72 243.8 0.0 4.2e-72 242.7 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CRG86264.1 - 1.7e-27 96.4 0.0 5.4e-27 94.8 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain SNRNP27 PF08648.12 CRG86265.1 - 1.6e-23 82.5 0.6 1.6e-23 82.5 0.6 1.7 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins DAO PF01266.24 CRG86266.1 - 1.8e-67 228.4 0.5 2e-67 228.2 0.5 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CRG86266.1 - 4.5e-06 25.8 0.4 0.006 15.5 0.1 2.1 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 CRG86266.1 - 4.8e-05 23.5 0.8 0.00013 22.2 0.8 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG86266.1 - 0.00011 21.6 1.1 0.15 11.2 0.0 2.8 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG86266.1 - 0.00096 19.7 0.6 0.46 11.1 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 CRG86266.1 - 0.013 15.8 0.0 0.079 13.2 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Thi4 PF01946.17 CRG86266.1 - 0.016 14.5 0.2 0.026 13.8 0.2 1.3 1 0 0 1 1 1 0 Thi4 family MCRA PF06100.11 CRG86266.1 - 0.017 14.0 0.2 0.028 13.2 0.2 1.3 1 0 0 1 1 1 0 MCRA family NAD_binding_9 PF13454.6 CRG86266.1 - 0.024 14.7 0.2 1.4 8.8 0.1 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CRG86266.1 - 0.04 13.0 0.5 0.24 10.4 0.5 1.9 1 1 0 1 1 1 0 FAD binding domain Amino_oxidase PF01593.24 CRG86266.1 - 0.072 12.4 0.1 0.76 9.0 0.1 2.3 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Mqo PF06039.15 CRG86266.1 - 0.12 10.9 0.0 2.3 6.7 0.0 2.0 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Glyco_hydro_63 PF03200.16 CRG86267.1 - 1.8e-171 571.3 6.5 2.8e-171 570.6 1.6 2.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 CRG86267.1 - 5e-90 301.6 0.0 1.1e-88 297.2 0.0 2.2 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 CRG86267.1 - 0.00024 20.0 0.1 0.00041 19.3 0.1 1.3 1 0 0 1 1 1 1 Trehalase MMtag PF10159.9 CRG86268.1 - 1.4e-32 111.8 4.0 1.4e-32 111.8 4.0 2.4 2 1 0 2 2 2 1 Multiple myeloma tumor-associated Peptidase_M50B PF13398.6 CRG86269.1 - 6.1e-58 195.8 22.9 1.2e-57 194.9 22.9 1.4 1 0 0 1 1 1 1 Peptidase M50B-like CRT10 PF08728.10 CRG86269.1 - 1.1e-12 47.0 0.0 3.4e-10 38.8 0.0 2.2 2 0 0 2 2 2 2 CRT10 Peptidase_M50 PF02163.22 CRG86269.1 - 0.037 13.3 0.3 0.1 11.9 0.2 1.6 2 0 0 2 2 2 0 Peptidase family M50 Patched PF02460.18 CRG86269.1 - 1.9 6.4 6.3 2.9 5.8 6.3 1.3 1 0 0 1 1 1 0 Patched family RabGAP-TBC PF00566.18 CRG86270.1 - 7.8e-37 127.0 0.7 1.5e-36 126.1 0.7 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 CRG86270.1 - 7.6e-09 35.3 0.0 1.2e-06 28.1 0.0 2.6 1 1 0 1 1 1 1 Rab-binding domain (RBD) PhoLip_ATPase_C PF16212.5 CRG86271.1 - 1.3e-49 169.2 6.7 1.3e-49 169.2 6.7 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CRG86271.1 - 8.6e-17 60.6 2.5 1.8e-16 59.6 2.5 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 CRG86271.1 - 7.5e-14 52.5 0.9 5.2e-08 33.4 0.7 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CRG86271.1 - 1.8e-08 34.3 0.0 4e-07 30.0 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 CRG86271.1 - 1.3e-05 24.9 2.7 0.0051 16.4 0.1 2.7 2 0 0 2 2 2 2 E1-E2 ATPase Hydrolase_3 PF08282.12 CRG86271.1 - 0.0055 16.5 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF3784 PF12650.7 CRG86271.1 - 2.7 8.2 5.9 0.49 10.6 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Sec16_C PF12931.7 CRG86272.1 - 3.4e-108 361.9 0.0 4.7e-108 361.4 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16_N PF12935.7 CRG86272.1 - 1.2e-33 117.3 46.9 1.6e-22 80.8 10.3 4.8 3 1 1 4 4 4 2 Vesicle coat trafficking protein Sec16 N-terminus Sec16 PF12932.7 CRG86272.1 - 1.1e-32 113.0 0.0 3.2e-32 111.6 0.0 1.9 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Sugar_tr PF00083.24 CRG86273.1 - 5.7e-83 279.3 19.5 7e-83 279.0 19.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86273.1 - 8.9e-28 97.2 21.1 8.9e-28 97.2 21.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG86273.1 - 4.8e-09 35.2 1.0 4.8e-09 35.2 1.0 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Mso1_Sec1_bdg PF14475.6 CRG86274.1 - 9.6e-15 53.9 0.0 1.7e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Ribosomal_L28e PF01778.17 CRG86275.1 - 3.5e-40 137.3 0.4 5.4e-40 136.7 0.4 1.3 1 0 0 1 1 1 1 Ribosomal L28e protein family Mak16 PF04874.14 CRG86275.1 - 1e-30 106.2 12.6 1e-30 106.2 12.6 2.3 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 CRG86275.1 - 3e-07 30.1 14.1 3.8e-07 29.8 14.1 1.1 1 0 0 1 1 1 1 BUD22 TFIIF_alpha PF05793.12 CRG86275.1 - 0.036 12.7 25.0 0.047 12.3 25.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PYC_OADA PF02436.18 CRG86275.1 - 0.083 12.6 0.7 0.15 11.8 0.4 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain TFIIA PF03153.13 CRG86275.1 - 1.8 8.5 12.5 2.2 8.2 12.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SURF2 PF05477.11 CRG86275.1 - 5.2 6.7 9.6 8.6 6.0 9.6 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF3402 PF11882.8 CRG86276.1 - 1.8e-189 630.7 0.0 2.3e-189 630.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) N1221 PF07923.13 CRG86276.1 - 1e-89 300.5 0.0 1.5e-89 300.0 0.0 1.3 1 0 0 1 1 1 1 N1221-like protein PAP2 PF01569.21 CRG86276.1 - 1.7e-11 44.0 2.0 3.8e-11 42.9 2.0 1.5 1 0 0 1 1 1 1 PAP2 superfamily 4HBT_3 PF13622.6 CRG86276.1 - 2.2e-06 28.1 3.9 5e-05 23.7 0.1 2.7 2 0 0 2 2 2 1 Thioesterase-like superfamily APG6_N PF17675.1 CRG86276.1 - 0.13 12.8 4.0 0.36 11.3 4.0 1.7 1 0 0 1 1 1 0 Apg6 coiled-coil region IBR PF01485.21 CRG86277.1 - 3.9e-20 71.8 40.8 1e-15 57.7 4.3 4.2 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 CRG86277.1 - 7.5e-19 68.1 0.0 1.3e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 RWD domain zf-RING_11 PF17123.5 CRG86277.1 - 0.0097 15.6 7.0 0.0097 15.6 7.0 2.4 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_2 PF13639.6 CRG86277.1 - 5 7.5 47.7 0.044 14.1 10.3 4.2 3 1 1 4 4 4 0 Ring finger domain GAS2 PF02187.17 CRG86278.1 - 1.2e-06 28.5 0.2 2.7e-06 27.4 0.2 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Hus1 PF04005.12 CRG86279.1 - 7.3e-99 330.6 0.0 1e-98 330.1 0.0 1.1 1 0 0 1 1 1 1 Hus1-like protein Hexokinase_2 PF03727.16 CRG86279.1 - 1.5e-74 250.5 0.0 2.1e-74 249.9 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CRG86279.1 - 1.4e-48 165.5 0.1 4.3e-46 157.3 0.1 2.3 1 1 0 1 1 1 1 Hexokinase Abhydrolase_6 PF12697.7 CRG86280.1 - 1.5e-13 51.9 0.0 2.5e-13 51.2 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG86280.1 - 4.1e-13 49.6 0.1 1.6e-12 47.7 0.0 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG86280.1 - 1.7e-10 40.6 0.0 2.3e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_8 PF06259.12 CRG86280.1 - 0.0012 18.5 0.1 0.0023 17.6 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase Thioesterase PF00975.20 CRG86280.1 - 0.0044 17.2 0.1 0.0056 16.8 0.1 1.4 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_5 PF12695.7 CRG86280.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Ser_hydrolase PF06821.13 CRG86280.1 - 0.17 11.7 0.0 0.17 11.7 0.0 2.1 2 1 1 3 3 3 0 Serine hydrolase 2-Hacid_dh_C PF02826.19 CRG86281.1 - 2e-48 164.1 0.2 3.1e-48 163.5 0.2 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG86281.1 - 4.2e-07 29.7 0.0 6.2e-07 29.1 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG86281.1 - 0.0028 17.8 0.0 0.0043 17.2 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.15 CRG86281.1 - 0.0045 17.4 0.0 0.041 14.3 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain HTH_1 PF00126.27 CRG86281.1 - 0.034 14.1 0.0 0.088 12.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family DUF1871 PF08958.10 CRG86281.1 - 0.07 13.5 0.1 11 6.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1871) DHDPS PF00701.22 CRG86282.1 - 8.6e-43 146.1 0.0 1e-42 145.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Zn_clus PF00172.18 CRG86283.1 - 1.1e-08 35.0 8.8 2.1e-08 34.1 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldo_ket_red PF00248.21 CRG86284.1 - 2.8e-47 161.4 0.0 7.7e-46 156.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Epimerase PF01370.21 CRG86285.1 - 1.2e-17 64.1 0.0 1.6e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG86285.1 - 6.2e-11 41.8 0.0 7.8e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG86285.1 - 1e-09 38.3 0.0 1.5e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG86285.1 - 2.4e-08 33.5 0.0 3.5e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG86285.1 - 5.3e-08 32.3 0.1 0.00098 18.4 0.0 2.9 2 1 0 2 2 2 2 Male sterility protein Ldh_1_N PF00056.23 CRG86285.1 - 0.0054 16.8 0.0 0.008 16.3 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG86285.1 - 0.0071 15.5 0.0 0.019 14.1 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CRG86285.1 - 0.062 13.2 0.1 0.17 11.8 0.1 1.6 1 1 0 1 1 1 0 KR domain adh_short PF00106.25 CRG86285.1 - 0.072 12.5 0.0 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 short chain dehydrogenase FMN_dh PF01070.18 CRG86286.1 - 5.4e-116 387.4 0.0 6.4e-116 387.2 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG86286.1 - 8e-22 77.2 0.1 1.8e-21 76.1 0.1 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CRG86286.1 - 2.6e-05 23.5 0.0 4.1e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG86286.1 - 0.00029 19.9 0.0 0.00047 19.3 0.0 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 CRG86286.1 - 0.0068 15.7 0.4 1 8.6 0.0 2.8 2 1 0 3 3 3 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 CRG86286.1 - 0.074 12.5 0.0 0.42 10.0 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein MFS_1 PF07690.16 CRG86287.1 - 2.2e-40 138.7 24.8 5.9e-37 127.4 12.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CRG86287.1 - 1.6e-09 37.5 0.1 5.4e-09 35.8 0.2 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF4736 PF15883.5 CRG86287.1 - 0.09 12.5 0.0 0.65 9.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) FMO-like PF00743.19 CRG86288.1 - 1e-35 123.2 0.0 8.6e-20 70.6 0.0 3.1 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG86288.1 - 4.6e-18 65.5 0.0 1.5e-12 47.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG86288.1 - 1.5e-14 53.9 0.0 2.9e-14 53.0 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG86288.1 - 8e-09 35.6 0.2 3.3e-08 33.6 0.0 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG86288.1 - 3e-08 33.6 4.9 4.8e-06 26.4 1.3 3.3 4 0 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG86288.1 - 3.9e-08 33.4 0.5 0.00014 21.9 0.0 3.5 4 0 0 4 4 4 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 CRG86288.1 - 6.6e-07 28.8 0.1 0.0014 17.8 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CRG86288.1 - 1.8e-05 25.2 0.7 0.0011 19.5 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG86288.1 - 0.00026 20.2 0.1 0.0005 19.3 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CRG86288.1 - 0.00033 20.1 0.0 0.00052 19.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG86288.1 - 0.00037 19.8 0.2 0.001 18.4 0.2 1.7 2 0 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.24 CRG86288.1 - 0.00039 19.8 0.2 0.0017 17.8 0.1 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 CRG86288.1 - 0.00053 20.1 0.4 0.037 14.1 0.1 2.6 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CRG86288.1 - 0.0024 18.1 0.0 0.036 14.2 0.0 2.2 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase HI0933_like PF03486.14 CRG86288.1 - 0.0029 16.4 0.8 0.0046 15.7 0.8 1.3 1 0 0 1 1 1 1 HI0933-like protein ApbA PF02558.16 CRG86288.1 - 0.0084 15.8 0.0 0.091 12.4 0.0 2.6 3 0 0 3 3 3 1 Ketopantoate reductase PanE/ApbA NAD_binding_7 PF13241.6 CRG86288.1 - 0.015 15.8 0.1 0.25 11.8 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 CRG86288.1 - 0.02 14.8 0.5 0.034 14.0 0.5 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CRG86288.1 - 0.023 14.0 0.3 0.039 13.2 0.3 1.3 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 CRG86288.1 - 0.032 13.5 2.9 0.035 13.4 0.7 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 CRG86288.1 - 0.037 13.6 0.1 0.078 12.5 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain GIDA PF01134.22 CRG86288.1 - 0.064 12.3 1.6 0.098 11.7 1.6 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A MCRA PF06100.11 CRG86288.1 - 0.073 11.9 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 MCRA family TauD PF02668.16 CRG86289.1 - 3.7e-59 200.7 0.2 4.5e-59 200.4 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Peptidase_C31 PF05410.13 CRG86289.1 - 0.096 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Porcine arterivirus-type cysteine proteinase alpha Pepsin-I3 PF06394.13 CRG86289.1 - 0.36 11.1 0.9 62 3.9 0.0 3.0 2 1 1 3 3 3 0 Pepsin inhibitor-3-like repeated domain MFS_1 PF07690.16 CRG86290.1 - 9.5e-36 123.4 23.3 2.3e-24 86.0 8.3 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86290.1 - 4.5e-12 45.6 4.6 4.5e-12 45.6 4.6 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 CRG86290.1 - 1.5e-05 24.1 5.8 1.5e-05 24.1 5.8 2.8 1 1 1 2 2 2 1 MFS_1 like family TRI12 PF06609.13 CRG86290.1 - 0.0016 16.9 1.8 0.0025 16.3 1.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 CRG86290.1 - 0.058 11.9 17.7 0.033 12.8 5.4 3.4 2 2 2 4 4 4 0 MFS/sugar transport protein DUF2530 PF10745.9 CRG86290.1 - 0.22 11.8 5.0 0.16 12.2 1.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) MFS_4 PF06779.14 CRG86290.1 - 0.76 9.0 12.0 0.018 14.3 2.8 2.5 3 0 0 3 3 3 0 Uncharacterised MFS-type transporter YbfB Lactonase PF10282.9 CRG86293.1 - 1.5e-73 248.0 0.1 1.9e-73 247.7 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Abhydrolase_1 PF00561.20 CRG86294.1 - 2.4e-29 102.8 0.1 2.9e-29 102.5 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG86294.1 - 7.1e-15 56.2 0.0 1e-14 55.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG86294.1 - 1.4e-09 37.6 0.0 1.2e-08 34.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 CRG86294.1 - 0.067 12.1 0.0 0.09 11.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 CRG86294.1 - 0.19 10.7 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Mpv17_PMP22 PF04117.12 CRG86295.1 - 1.1e-20 73.6 0.2 2.1e-20 72.7 0.2 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family CutC PF03932.14 CRG86296.1 - 3.6e-53 180.1 0.0 1.1e-52 178.5 0.0 1.8 1 1 0 1 1 1 1 CutC family Catalase PF00199.19 CRG86297.1 - 6.9e-173 575.1 0.2 8.9e-173 574.8 0.2 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 CRG86297.1 - 6.4e-17 61.5 0.1 1.8e-16 60.1 0.1 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 CRG86297.1 - 1.8e-07 30.9 0.1 3.4e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 CRG86297.1 - 7.2e-07 29.1 0.0 8.5e-06 25.7 0.0 2.1 1 1 1 2 2 2 1 DJ-1/PfpI family Cyclase PF04199.13 CRG86298.1 - 6.5e-15 55.6 0.0 9e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Putative cyclase SRP-alpha_N PF04086.13 CRG86299.1 - 8.3e-83 278.7 0.1 1.1e-82 278.2 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 CRG86299.1 - 4.1e-49 166.9 0.0 7.2e-49 166.1 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 CRG86299.1 - 4.8e-11 42.7 0.0 1.2e-10 41.4 0.0 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 CRG86299.1 - 5.3e-07 28.9 0.0 1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 CRG86299.1 - 0.00071 19.3 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG86299.1 - 0.0039 17.6 0.0 0.015 15.7 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.23 CRG86299.1 - 0.019 15.0 0.0 0.074 13.1 0.0 2.1 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ABC_tran PF00005.27 CRG86299.1 - 0.028 14.9 0.0 0.22 12.1 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_24 PF13479.6 CRG86299.1 - 0.028 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 CRG86299.1 - 0.044 13.2 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SMC_N PF02463.19 CRG86299.1 - 0.05 13.0 0.0 0.095 12.1 0.0 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CRG86299.1 - 0.056 13.5 0.1 0.25 11.4 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_31 PF13614.6 CRG86299.1 - 0.067 13.1 0.0 0.42 10.5 0.0 2.0 1 1 1 2 2 2 0 AAA domain DUF4682 PF15733.5 CRG86299.1 - 0.19 12.4 0.7 0.84 10.2 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4682) YIF1 PF03878.15 CRG86300.1 - 5.7e-100 333.8 3.6 6.7e-100 333.5 3.6 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 CRG86300.1 - 0.0011 18.7 6.8 0.0011 18.7 6.8 1.7 2 0 0 2 2 2 1 Yip1 domain RGS PF00615.19 CRG86301.1 - 0.016 15.5 0.0 2.8 8.3 0.0 2.3 2 0 0 2 2 2 0 Regulator of G protein signaling domain Ribosomal_L14e PF01929.17 CRG86302.1 - 3.9e-32 110.6 1.1 6.3e-32 109.9 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 CRG86302.1 - 3.8e-08 33.0 1.2 5.9e-08 32.4 1.2 1.3 1 0 0 1 1 1 1 KOW motif Prot_ATP_ID_OB PF16450.5 CRG86302.1 - 0.028 14.4 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain NAC PF01849.18 CRG86303.1 - 2.8e-22 78.4 0.0 1.3e-21 76.3 0.0 2.0 2 0 0 2 2 2 1 NAC domain RNA_pol_Rpo13 PF12136.8 CRG86303.1 - 0.024 14.6 3.9 0.024 14.6 3.9 1.9 2 0 0 2 2 2 0 RNA polymerase Rpo13 subunit HTH domain Menin PF05053.13 CRG86303.1 - 0.16 10.3 4.2 0.24 9.7 4.2 1.3 1 0 0 1 1 1 0 Menin Pes-10 PF07149.11 CRG86303.1 - 0.67 9.0 7.9 0.35 9.9 5.9 1.6 2 0 0 2 2 2 0 Pes-10 Mt_ATP-synt_D PF05873.12 CRG86304.1 - 2.1e-23 82.9 2.1 2.7e-23 82.5 2.1 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) GIDA_assoc PF13932.6 CRG86304.1 - 0.014 15.6 1.1 0.018 15.3 1.1 1.1 1 0 0 1 1 1 0 GidA associated domain DUF3251 PF11622.8 CRG86304.1 - 0.065 12.9 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3251) DUF2408 PF10303.9 CRG86304.1 - 0.089 13.4 1.2 0.14 12.7 1.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Spectrin PF00435.21 CRG86304.1 - 0.095 13.2 3.0 1.1 9.7 0.4 2.1 1 1 0 2 2 2 0 Spectrin repeat LTXXQ PF07813.12 CRG86304.1 - 0.14 12.8 2.2 1.3 9.7 0.4 2.1 2 0 0 2 2 2 0 LTXXQ motif family protein XhlA PF10779.9 CRG86304.1 - 0.2 11.9 2.5 0.2 11.9 0.9 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Enkurin PF13864.6 CRG86304.1 - 0.3 11.6 2.7 1.2 9.6 0.6 2.2 1 1 1 2 2 2 0 Calmodulin-binding FAM217 PF15344.6 CRG86305.1 - 0.042 13.8 0.2 0.072 13.0 0.2 1.3 1 0 0 1 1 1 0 FAM217 family GPHR_N PF12537.8 CRG86307.1 - 0.89 9.7 3.1 2.2 8.4 3.1 1.8 1 1 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Aldedh PF00171.22 CRG86308.1 - 1.6e-116 389.6 0.0 2.5e-116 389.0 0.0 1.3 1 0 0 1 1 1 1 Aldehyde dehydrogenase family HhH-GPD PF00730.25 CRG86308.1 - 0.0028 18.1 0.0 0.0069 16.8 0.0 1.7 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CRG86308.1 - 0.03 14.2 0.1 0.21 11.5 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif DNA_methylase PF00145.17 CRG86309.1 - 1.4e-42 146.3 0.0 2.8e-28 99.2 0.0 2.4 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase MmgE_PrpD PF03972.14 CRG86310.1 - 5.5e-146 486.5 0.0 6.4e-146 486.3 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DUF1266 PF06889.11 CRG86310.1 - 0.046 13.8 0.1 3 7.9 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1266) Aminotran_1_2 PF00155.21 CRG86311.1 - 5.3e-39 134.4 0.0 7e-39 134.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II LtrA PF06772.11 CRG86311.1 - 7.8e-35 120.7 21.3 1.1e-34 120.2 21.3 1.2 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Aminotran_3 PF00202.21 CRG86311.1 - 2.9e-05 22.9 0.0 3.9e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Cys_Met_Meta_PP PF01053.20 CRG86311.1 - 0.00015 20.4 0.0 0.00025 19.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_3 PF00202.21 CRG86312.1 - 1.7e-34 119.2 0.0 8.9e-17 60.8 0.0 3.1 2 1 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.6 CRG86312.1 - 1.2e-21 77.5 0.0 2.2e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 CRG86312.1 - 0.061 13.4 0.1 0.22 11.6 0.1 1.9 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain INTAP PF16617.5 CRG86312.1 - 0.062 13.7 0.7 0.14 12.5 0.7 1.6 1 0 0 1 1 1 0 Intersectin and clathrin adaptor AP2 binding region GAS PF13851.6 CRG86313.1 - 0.0054 16.1 1.6 0.0054 16.1 1.6 4.4 3 2 1 4 4 4 2 Growth-arrest specific micro-tubule binding FlxA PF14282.6 CRG86313.1 - 0.0067 16.4 28.4 0.01 15.8 2.3 3.8 2 2 1 3 3 3 2 FlxA-like protein Cas_Csa4 PF09703.10 CRG86313.1 - 0.009 15.4 0.3 0.022 14.1 0.3 1.7 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csa4) Rx_N PF18052.1 CRG86313.1 - 0.027 14.7 4.4 0.29 11.4 0.1 3.2 2 2 0 2 2 2 0 Rx N-terminal domain PRKG1_interact PF15898.5 CRG86313.1 - 0.3 12.0 21.3 3 8.8 0.0 4.5 3 1 1 4 4 4 0 cGMP-dependent protein kinase interacting domain DUF3138 PF11336.8 CRG86313.1 - 2.8 6.4 9.2 2.6 6.6 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Fib_alpha PF08702.10 CRG86313.1 - 4.2 7.5 22.7 2.8 8.1 0.4 3.9 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.22 CRG86313.1 - 5 7.4 19.5 0.33 11.2 4.9 3.6 2 1 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain BATS PF06968.13 CRG86314.1 - 6.8e-22 77.4 0.0 2e-21 75.9 0.0 1.8 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 CRG86314.1 - 1.5e-15 58.0 0.0 5.2e-14 53.0 0.0 2.7 3 0 0 3 3 3 1 Radical SAM superfamily AMP-binding PF00501.28 CRG86315.1 - 9.8e-70 235.2 0.0 1.2e-69 235.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG86315.1 - 0.00051 21.0 0.1 0.00098 20.1 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Citrate_synt PF00285.21 CRG86316.1 - 3.7e-98 328.9 0.0 4.5e-98 328.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain ICL PF00463.21 CRG86317.1 - 9.9e-190 631.5 0.0 1.1e-189 631.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CRG86317.1 - 2.3e-08 33.8 0.0 4.7e-08 32.8 0.0 1.5 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF2458 PF10454.9 CRG86317.1 - 0.17 11.5 1.3 0.27 10.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2458) ABC_tran PF00005.27 CRG86318.1 - 2e-47 161.2 0.1 8.6e-25 87.8 0.0 4.2 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CRG86318.1 - 1.8e-14 54.3 0.1 0.00024 21.0 0.0 4.4 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG86318.1 - 3.6e-13 49.5 0.2 0.00091 18.7 0.0 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG86318.1 - 7.6e-08 33.1 3.0 0.00076 20.0 0.0 2.7 3 0 0 3 3 2 2 AAA domain Chromo PF00385.24 CRG86318.1 - 5.7e-07 29.3 0.0 1.1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_29 PF13555.6 CRG86318.1 - 1.3e-06 28.0 1.6 0.012 15.3 0.6 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG86318.1 - 1.5e-06 28.3 0.1 0.014 15.3 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CRG86318.1 - 3e-06 27.3 0.0 0.077 13.1 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 CRG86318.1 - 2.6e-05 24.1 0.5 0.019 14.7 0.4 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CRG86318.1 - 0.00026 21.3 0.0 0.43 10.8 0.0 3.2 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CRG86318.1 - 0.00082 19.5 0.7 0.49 10.5 0.1 3.4 4 0 0 4 4 3 1 Helicase HerA, central domain AAA_28 PF13521.6 CRG86318.1 - 0.00085 19.6 0.0 0.57 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain DNA_ligase_OB_2 PF14743.6 CRG86318.1 - 0.0011 18.9 0.3 0.0041 17.1 0.3 2.0 1 0 0 1 1 1 1 DNA ligase OB-like domain SbcCD_C PF13558.6 CRG86318.1 - 0.0034 17.6 0.0 1.9 8.8 0.0 3.4 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 CRG86318.1 - 0.021 15.0 0.0 5.7 7.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CRG86318.1 - 0.022 14.8 0.0 0.57 10.2 0.0 2.9 2 0 0 2 2 2 0 Dynamin family AAA_24 PF13479.6 CRG86318.1 - 0.023 14.5 1.0 1.2 8.8 0.2 2.4 2 0 0 2 2 2 0 AAA domain ALF PF03752.13 CRG86318.1 - 0.023 14.7 2.0 4.9 7.2 0.4 3.5 3 0 0 3 3 3 0 Short repeats of unknown function RNA_helicase PF00910.22 CRG86318.1 - 0.023 15.1 0.1 4.9 7.6 0.0 2.6 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 CRG86318.1 - 0.024 14.5 2.1 1 9.2 0.0 3.0 3 0 0 3 3 3 0 NACHT domain MukB PF04310.12 CRG86318.1 - 0.032 14.0 0.4 5.4 6.8 0.1 2.7 2 0 0 2 2 2 0 MukB N-terminal AAA_13 PF13166.6 CRG86318.1 - 0.035 12.8 0.0 2.4 6.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain MnmE_helical PF12631.7 CRG86318.1 - 0.043 14.0 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 MnmE helical domain MeaB PF03308.16 CRG86318.1 - 0.054 12.5 0.4 7.6 5.4 0.0 2.4 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CRG86318.1 - 0.07 13.7 0.1 9.9 6.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain ATP-synt_ab PF00006.25 CRG86318.1 - 0.076 12.7 0.2 16 5.1 0.0 2.8 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain HEAT PF02985.22 CRG86318.1 - 0.077 13.3 0.2 1.4e+02 3.1 0.1 4.6 4 0 0 4 4 4 0 HEAT repeat AAA_27 PF13514.6 CRG86318.1 - 0.084 12.4 0.1 13 5.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain SR-25 PF10500.9 CRG86318.1 - 0.088 12.4 1.1 0.19 11.3 1.1 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF815 PF05673.13 CRG86318.1 - 0.12 11.5 0.1 6.9 5.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Stork_head PF10264.9 CRG86318.1 - 0.16 12.2 0.2 0.5 10.6 0.2 1.8 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain AAA_30 PF13604.6 CRG86318.1 - 0.24 11.1 4.7 7.3 6.3 0.2 3.2 4 0 0 4 4 3 0 AAA domain DUF3584 PF12128.8 CRG86318.1 - 0.32 8.5 1.1 4.3 4.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_19 PF13245.6 CRG86318.1 - 0.5 10.7 2.3 16 5.8 0.1 3.0 3 0 0 3 3 3 0 AAA domain DUF3632 PF12311.8 CRG86319.1 - 2.4e-27 96.5 0.1 3.2e-27 96.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) DUF3632 PF12311.8 CRG86320.1 - 3.8e-21 76.3 0.2 4.6e-21 76.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Glyco_hydro_3_C PF01915.22 CRG86321.1 - 3.2e-45 154.6 0.0 1.2e-44 152.8 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG86321.1 - 1.2e-39 136.6 0.0 1.8e-39 136.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG86321.1 - 2.7e-21 75.5 0.5 5.3e-21 74.5 0.5 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain FliG_M PF14841.6 CRG86321.1 - 0.12 12.7 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 FliG middle domain HATPase_c PF02518.26 CRG86322.1 - 5.7e-28 97.7 0.0 3.2e-27 95.2 0.0 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG86322.1 - 2.1e-24 85.8 0.5 3.8e-24 85.0 0.5 1.4 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CRG86322.1 - 5.9e-14 51.9 0.0 1.3e-13 50.7 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 CRG86322.1 - 0.0084 16.5 0.1 0.14 12.5 0.1 2.7 2 0 0 2 2 2 1 HAMP domain L51_S25_CI-B8 PF05047.16 CRG86323.1 - 5.7e-13 48.6 0.0 7.4e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MPC PF03650.13 CRG86324.1 - 5.5e-49 164.9 0.4 7.4e-49 164.5 0.4 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers CBP4 PF07960.11 CRG86326.1 - 8e-33 113.1 3.4 1.2e-32 112.5 3.4 1.3 1 0 0 1 1 1 1 CBP4 DDE_Tnp_1_6 PF13751.6 CRG86326.1 - 0.13 12.5 4.9 0.18 12.0 4.9 1.2 1 0 0 1 1 1 0 Transposase DDE domain DUF5345 PF17280.2 CRG86326.1 - 1.8 8.6 6.7 0.38 10.8 2.7 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Sel1 PF08238.12 CRG86327.1 - 1.3e-43 146.4 27.3 2.3e-08 34.4 1.0 7.6 7 0 0 7 7 7 7 Sel1 repeat PI3K_C2 PF00792.24 CRG86327.1 - 0.013 15.4 0.0 0.024 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase C2 TPR_11 PF13414.6 CRG86327.1 - 0.02 14.6 1.7 5.6 6.7 0.0 3.8 3 0 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 CRG86327.1 - 1.7 9.4 10.8 23 5.9 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat Abhydrolase_3 PF07859.13 CRG86328.1 - 3.2e-33 115.4 0.1 4.2e-33 115.0 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Lipase_3 PF01764.25 CRG86328.1 - 0.086 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Amidase PF01425.21 CRG86329.1 - 4.3e-97 325.9 0.0 1.9e-96 323.8 0.0 1.8 1 1 0 1 1 1 1 Amidase Fungal_trans_2 PF11951.8 CRG86330.1 - 4.7e-13 48.7 0.1 1.4e-07 30.7 0.0 2.2 1 1 1 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86330.1 - 8.5e-07 29.0 6.2 2.4e-06 27.5 6.2 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG86331.1 - 3.4e-30 105.2 27.9 3.4e-30 105.2 27.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily DEAD PF00270.29 CRG86333.1 - 8.6e-16 58.2 0.0 1.8e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG86333.1 - 2.6e-11 43.8 0.0 9.2e-11 42.0 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ATP_transf PF09830.9 CRG86333.1 - 2.4e-10 40.4 0.0 1e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 ATP adenylyltransferase Helicase_C PF00271.31 CRG86333.1 - 3.3e-06 27.4 0.0 9e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PhoH PF02562.16 CRG86333.1 - 0.037 13.5 0.0 0.09 12.2 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein adh_short_C2 PF13561.6 CRG86334.1 - 2.7e-59 200.6 0.2 3.1e-59 200.4 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86334.1 - 4.4e-40 137.2 0.1 5.3e-40 137.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86334.1 - 5.7e-10 39.4 0.7 9.2e-10 38.7 0.7 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CRG86334.1 - 0.00052 19.9 0.1 0.00099 19.0 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG86334.1 - 0.0072 15.5 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 CRG86334.1 - 0.014 14.7 0.3 0.051 12.9 0.2 1.9 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3Beta_HSD PF01073.19 CRG86334.1 - 0.029 13.4 0.2 0.083 11.9 0.2 1.8 1 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_12 PF08242.12 CRG86334.1 - 0.042 14.6 0.0 0.087 13.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 CRG86334.1 - 0.071 12.6 0.1 0.11 11.9 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG86334.1 - 0.08 12.8 2.7 0.28 11.1 0.5 2.3 2 1 0 2 2 2 0 NAD(P)H-binding Gln-synt_C PF00120.24 CRG86335.1 - 7e-83 278.5 0.0 8.5e-83 278.2 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Viral_alk_exo PF01771.17 CRG86335.1 - 0.16 10.8 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 Viral alkaline exonuclease Malate_synthase PF01274.22 CRG86336.1 - 1.9e-230 765.6 0.0 2.1e-230 765.5 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Meth_synt_2 PF01717.18 CRG86337.1 - 1.8e-12 47.2 0.0 6.5e-12 45.4 0.0 1.8 1 1 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Dynamin_N PF00350.23 CRG86338.1 - 4.3e-33 114.7 0.2 7.9e-33 113.9 0.2 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 CRG86338.1 - 2.3e-20 73.0 0.0 1.5e-19 70.4 0.0 2.1 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 CRG86338.1 - 3.4e-05 23.9 0.3 0.00014 21.9 0.1 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase Wtap PF17098.5 CRG86338.1 - 0.022 14.7 0.7 0.14 12.1 0.0 2.5 2 1 0 2 2 2 0 WTAP/Mum2p family AAA_21 PF13304.6 CRG86338.1 - 0.026 14.4 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 CRG86338.1 - 0.12 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_16 PF13191.6 CRG86338.1 - 0.14 12.5 0.2 1.2 9.5 0.0 2.5 2 0 0 2 2 2 0 AAA ATPase domain MSA-2c PF12238.8 CRG86338.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.5 3 0 0 3 3 3 0 Merozoite surface antigen 2c HsbA PF12296.8 CRG86339.1 - 9.2e-27 93.9 13.8 9.2e-27 93.9 13.8 2.0 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Baculo_PEP_C PF04513.12 CRG86339.1 - 0.01 15.8 14.6 0.16 12.0 1.6 2.6 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5344 PF17279.2 CRG86339.1 - 0.25 11.9 2.9 0.47 11.1 0.3 2.5 3 1 0 3 3 3 0 Family of unknown function (DUF5344) Spidroin_N PF16763.5 CRG86339.1 - 0.43 10.6 8.7 0.25 11.4 1.5 2.5 1 1 2 3 3 3 0 Major ampullate spidroin 1, spider silk protein 1, N-term Arf PF00025.21 CRG86341.1 - 2.4e-70 235.6 0.0 3e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Hva1_TUDOR PF11160.8 CRG86341.1 - 1.2e-18 67.1 0.9 2e-18 66.3 0.9 1.4 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain Roc PF08477.13 CRG86341.1 - 8.3e-15 55.1 0.1 1.2e-14 54.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CRG86341.1 - 2.6e-12 46.6 0.0 3.6e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 CRG86341.1 - 7.3e-12 45.1 0.0 1e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 CRG86341.1 - 1.6e-11 44.0 1.2 1.8e-07 30.7 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 CRG86341.1 - 4.5e-10 39.3 0.0 6.1e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CRG86341.1 - 0.00022 21.3 0.0 0.00049 20.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 CRG86341.1 - 0.011 15.1 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Glycos_transf_1 PF00534.20 CRG86342.1 - 1.6e-17 63.6 0.0 3.1e-17 62.6 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG86342.1 - 1.7e-13 51.1 0.0 3e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CRG86342.1 - 0.00025 21.4 0.0 0.00067 20.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Hexapep PF00132.24 CRG86343.1 - 1.9e-06 27.4 10.2 0.00041 20.0 3.8 4.7 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG86343.1 - 0.002 17.8 4.1 0.0033 17.1 0.2 2.9 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 CRG86343.1 - 0.08 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 L-fucokinase ABC2_membrane PF01061.24 CRG86344.1 - 5.2e-78 261.3 60.8 1.5e-42 145.4 25.1 3.8 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 CRG86344.1 - 2.9e-37 128.2 1.0 6.4e-18 65.6 0.0 3.3 4 0 0 4 4 4 2 ABC transporter PDR_CDR PF06422.12 CRG86344.1 - 2.4e-31 107.5 1.3 2.4e-31 107.5 1.3 3.9 4 0 0 4 4 3 2 CDR ABC transporter ABC_trans_N PF14510.6 CRG86344.1 - 1.3e-13 51.3 0.1 4.9e-13 49.5 0.1 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 CRG86344.1 - 9.4e-07 29.4 0.3 0.0044 17.4 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CRG86344.1 - 4.9e-05 23.0 0.1 0.0017 18.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CRG86344.1 - 7.7e-05 22.3 1.4 0.053 13.3 0.1 3.8 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_33 PF13671.6 CRG86344.1 - 0.00013 22.1 0.2 0.067 13.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CRG86344.1 - 0.00016 22.2 0.0 0.018 15.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CRG86344.1 - 0.00021 21.2 0.3 0.005 16.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_17 PF13207.6 CRG86344.1 - 0.0072 16.8 0.6 0.18 12.3 0.0 3.1 4 0 0 4 4 2 1 AAA domain AAA_22 PF13401.6 CRG86344.1 - 0.011 16.1 0.3 2 8.7 0.1 2.8 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 CRG86344.1 - 0.016 15.1 0.0 0.17 11.7 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase SMC_N PF02463.19 CRG86344.1 - 0.016 14.7 0.1 0.14 11.5 0.0 2.5 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 CRG86344.1 - 0.02 14.8 1.1 2.2 8.2 0.1 2.8 3 0 0 3 3 3 0 NACHT domain AAA_30 PF13604.6 CRG86344.1 - 0.033 13.9 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CRG86344.1 - 0.048 13.7 0.1 17 5.6 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 CRG86344.1 - 0.11 12.1 1.8 0.13 11.8 0.1 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 CRG86344.1 - 0.15 12.5 0.0 32 5.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_21 PF13304.6 CRG86344.1 - 0.43 10.4 5.8 2.1 8.1 0.1 3.1 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Tmemb_cc2 PF10267.9 CRG86345.1 - 0.17 11.0 5.7 0.2 10.8 5.7 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Sugar_tr PF00083.24 CRG86346.1 - 1.7e-129 432.6 14.8 2e-129 432.4 14.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86346.1 - 3.1e-26 92.2 18.2 3.1e-26 92.2 18.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3188 PF11384.8 CRG86346.1 - 8 6.3 7.6 6 6.7 2.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) MBOAT_2 PF13813.6 CRG86347.1 - 1e-15 57.8 8.4 1e-15 57.8 8.4 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family LOR PF04525.12 CRG86347.1 - 0.00023 20.8 0.3 0.00036 20.2 0.3 1.3 1 0 0 1 1 1 1 LURP-one-related DUF726 PF05277.12 CRG86348.1 - 0.0041 16.1 3.6 0.0057 15.6 3.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) CLP_protease PF00574.23 CRG86348.1 - 0.051 13.4 0.8 0.067 13.1 0.8 1.2 1 0 0 1 1 1 0 Clp protease Ni_hydr_CYTB PF01292.20 CRG86349.1 - 0.037 13.6 8.6 0.17 11.5 8.6 2.2 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 DUF3270 PF11674.8 CRG86349.1 - 0.13 12.5 0.1 0.13 12.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) PhoLip_ATPase_C PF16212.5 CRG86349.1 - 2 8.1 12.0 0.26 11.0 6.8 1.9 1 1 1 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal COPI_assoc PF08507.10 CRG86349.1 - 5.8 7.0 9.4 0.92 9.6 3.0 2.4 2 0 0 2 2 2 0 COPI associated protein AMP-binding PF00501.28 CRG86350.1 - 4.3e-63 213.4 0.0 5.7e-63 213.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG86350.1 - 1e-12 48.9 0.2 2e-12 47.9 0.2 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LPD23 PF18838.1 CRG86351.1 - 0.06 13.1 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 Glyco_transf_8 PF01501.20 CRG86352.1 - 0.4 10.2 1.8 3.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 8 TauD PF02668.16 CRG86353.1 - 0.05 13.4 0.0 0.068 13.0 0.0 1.2 1 0 0 1 1 1 0 Taurine catabolism dioxygenase TauD, TfdA family CorA PF01544.18 CRG86354.1 - 5.6e-05 22.6 7.3 0.00024 20.5 7.3 2.0 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF4381 PF14316.6 CRG86354.1 - 0.27 11.5 0.8 0.52 10.5 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Ank_2 PF12796.7 CRG86355.1 - 1.8e-52 175.9 1.5 6.8e-15 55.4 0.1 7.5 5 2 2 7 7 7 7 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG86355.1 - 9.7e-39 127.0 10.1 0.00033 20.9 0.2 13.4 14 0 0 14 14 14 8 Ankyrin repeat Ank_4 PF13637.6 CRG86355.1 - 2.2e-37 127.0 3.2 1e-07 32.4 0.1 9.8 6 4 4 10 10 10 8 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG86355.1 - 6.2e-34 115.6 13.7 3.3e-08 33.6 1.5 8.9 7 4 4 11 11 11 8 Ankyrin repeats (many copies) Ank PF00023.30 CRG86355.1 - 8.9e-27 92.3 17.6 5.3e-06 26.6 1.2 9.8 11 0 0 11 11 11 5 Ankyrin repeat MBOAT_2 PF13813.6 CRG86356.1 - 4.9e-19 68.4 2.8 1.4e-18 66.9 2.8 1.8 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family S1-P1_nuclease PF02265.16 CRG86357.1 - 3.5e-73 246.5 0.0 4e-73 246.3 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease NAD_binding_4 PF07993.12 CRG86361.1 - 6.6e-72 241.8 0.0 9.9e-72 241.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG86361.1 - 3.3e-71 240.1 0.0 7.6e-71 238.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CRG86361.1 - 1.2e-08 35.1 0.0 3.4e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 CRG86361.1 - 2.5e-07 30.4 0.0 7.6e-07 28.8 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG86361.1 - 3.7e-06 26.2 0.0 6.9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 CRG86361.1 - 3.6e-05 24.7 0.0 0.00014 22.7 0.0 2.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 CRG86361.1 - 0.032 14.1 0.3 0.65 9.9 0.2 3.1 2 1 0 2 2 2 0 NAD(P)H-binding Creatinase_N PF01321.18 CRG86361.1 - 0.055 14.1 0.0 13 6.4 0.0 2.6 2 0 0 2 2 2 0 Creatinase/Prolidase N-terminal domain KR PF08659.10 CRG86361.1 - 0.068 13.1 0.1 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 KR domain GST_N PF02798.20 CRG86362.1 - 9.6e-10 38.7 0.0 2.2e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG86362.1 - 9.2e-07 29.1 0.0 1.6e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG86362.1 - 7.8e-06 26.0 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG86362.1 - 0.00013 22.3 0.0 0.00029 21.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG86362.1 - 0.00017 21.7 0.0 0.00032 20.8 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG86362.1 - 0.00036 20.5 0.0 0.00089 19.2 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SnoaL_4 PF13577.6 CRG86363.1 - 0.015 15.5 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain Glyco_hydro_35 PF01301.19 CRG86364.1 - 2.2e-84 283.8 1.8 2.9e-84 283.4 1.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 CRG86364.1 - 5.9e-55 185.9 0.0 9.4e-55 185.2 0.0 1.3 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 CRG86364.1 - 2.3e-50 169.9 7.2 2.7e-32 111.7 0.1 2.7 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 CRG86364.1 - 1.3e-22 79.1 0.4 4.5e-22 77.4 0.1 2.0 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 MARVEL PF01284.23 CRG86365.1 - 5.1e-09 36.3 13.9 6.5e-09 36.0 13.9 1.1 1 0 0 1 1 1 1 Membrane-associating domain Rib PF08428.10 CRG86367.1 - 0.022 14.7 0.5 0.062 13.3 0.5 1.7 1 0 0 1 1 1 0 Rib/alpha-like repeat Peptidase_S9 PF00326.21 CRG86368.1 - 7.1e-39 133.5 0.2 1.3e-38 132.6 0.0 1.5 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 CRG86368.1 - 3.3e-10 39.9 0.0 1.4e-09 37.8 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 CRG86368.1 - 1.2e-05 25.4 0.0 6.8e-05 22.9 0.0 2.0 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 CRG86368.1 - 1.3e-05 25.0 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 CRG86368.1 - 1.9e-05 24.4 0.7 0.037 13.6 1.9 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Hydrolase_4 PF12146.8 CRG86368.1 - 1.9e-05 24.0 0.1 0.00044 19.6 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 AXE1 PF05448.12 CRG86368.1 - 0.0001 21.1 0.0 0.00084 18.1 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Abhydrolase_4 PF08386.10 CRG86368.1 - 0.00017 21.7 0.0 0.00039 20.5 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein PD40 PF07676.12 CRG86368.1 - 0.00059 19.7 0.4 0.0072 16.2 0.3 2.6 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat SGL PF08450.12 CRG86368.1 - 0.0069 16.0 0.0 0.031 13.9 0.0 2.0 2 0 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Abhydrolase_2 PF02230.16 CRG86368.1 - 0.015 15.1 0.0 4.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CRG86368.1 - 0.015 15.1 0.0 0.051 13.4 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 CRG86368.1 - 0.021 14.5 0.2 0.12 12.0 0.0 2.2 1 1 1 2 2 2 0 alpha/beta hydrolase fold Esterase_phd PF10503.9 CRG86368.1 - 0.025 14.0 0.1 0.42 10.1 0.1 2.5 2 0 0 2 2 2 0 Esterase PHB depolymerase DUF829 PF05705.14 CRG86368.1 - 0.15 11.9 0.0 0.26 11.1 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Sulfatase PF00884.23 CRG86370.1 - 1.6e-67 228.1 0.0 2e-67 227.8 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 CRG86370.1 - 0.068 13.9 0.0 1.2 9.9 0.0 2.7 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase Sugar_tr PF00083.24 CRG86371.1 - 3.2e-40 138.3 9.4 3.7e-40 138.2 9.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86371.1 - 7.6e-11 41.5 10.0 8.3e-11 41.4 10.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5423 PF17461.2 CRG86371.1 - 0.058 12.2 1.4 0.084 11.7 1.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Abhydrolase_3 PF07859.13 CRG86372.1 - 8.4e-23 81.3 0.0 1.4e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold FAD_binding_8 PF08022.12 CRG86372.1 - 0.00078 19.5 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 CRG86372.1 - 0.0021 18.2 0.0 0.0035 17.5 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Chlorophyllase2 PF12740.7 CRG86372.1 - 0.1 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Pkinase PF00069.25 CRG86373.1 - 1.7e-11 44.0 0.4 2.3e-11 43.6 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86373.1 - 5.8e-07 29.1 0.5 7.9e-07 28.6 0.5 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CRG86373.1 - 0.0004 20.0 0.4 0.00056 19.6 0.4 1.2 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CRG86373.1 - 0.00056 18.9 0.2 0.00071 18.6 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CRG86373.1 - 0.058 12.7 0.0 0.065 12.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Sugar_tr PF00083.24 CRG86374.1 - 3.3e-20 72.4 2.3 3.9e-20 72.1 2.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Hanta_nucleocap PF00846.18 CRG86374.1 - 0.019 13.4 0.0 0.028 12.9 0.0 1.2 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein DUF1772 PF08592.11 CRG86375.1 - 2.4e-32 112.1 3.1 2.9e-32 111.8 3.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) zf-C2H2_4 PF13894.6 CRG86376.1 - 0.0011 19.6 6.1 0.026 15.4 1.1 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG86376.1 - 0.0079 16.5 7.8 0.68 10.3 1.4 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CRG86376.1 - 0.023 14.7 1.4 0.062 13.3 1.4 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger RNase_T PF00929.24 CRG86376.1 - 0.08 13.5 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 Exonuclease Rad50_zn_hook PF04423.14 CRG86376.1 - 0.082 12.8 1.0 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 Rad50 zinc hook motif zf-C2H2 PF00096.26 CRG86376.1 - 0.12 12.9 7.7 0.1 13.1 2.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-met PF12874.7 CRG86376.1 - 0.19 12.1 2.1 6.6 7.3 0.1 2.6 1 1 1 2 2 2 0 Zinc-finger of C2H2 type Prok-RING_4 PF14447.6 CRG86376.1 - 0.23 11.4 2.2 7.5 6.5 0.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C2H2_2 PF12756.7 CRG86376.1 - 0.67 10.3 5.9 2.1 8.7 3.9 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 CRG86376.1 - 0.7 10.2 5.9 16 5.9 6.2 2.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Sugar_tr PF00083.24 CRG86377.1 - 2.7e-68 230.9 29.2 1.7e-49 168.9 15.0 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG86377.1 - 6.4e-12 45.1 39.9 5.2e-07 28.9 18.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily GFO_IDH_MocA PF01408.22 CRG86378.1 - 2.1e-16 60.8 0.0 3.2e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG86378.1 - 0.054 14.1 0.0 0.09 13.4 0.0 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain Zn_clus PF00172.18 CRG86379.1 - 2.7e-09 37.0 7.0 4.8e-09 36.2 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4924 PF16271.5 CRG86379.1 - 0.024 14.6 0.3 0.05 13.6 0.2 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4924) GFO_IDH_MocA PF01408.22 CRG86380.1 - 7.9e-15 55.7 0.0 1.4e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG86380.1 - 0.055 14.1 0.0 0.32 11.7 0.0 2.1 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Peptidase_M20 PF01546.28 CRG86381.1 - 1.6e-10 41.1 0.1 2.5e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG86381.1 - 3e-08 33.6 0.0 4.8e-07 29.7 0.0 2.3 2 0 0 2 2 2 1 Peptidase dimerisation domain DUF3763 PF12592.8 CRG86381.1 - 0.1 12.7 0.4 0.19 11.8 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3763) AATase PF07247.12 CRG86381.1 - 0.11 11.0 0.0 0.75 8.3 0.0 1.9 2 0 0 2 2 2 0 Alcohol acetyltransferase Pkinase PF00069.25 CRG86382.1 - 2.3e-20 73.1 0.0 1.2e-19 70.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86382.1 - 1.9e-10 40.5 0.0 3e-08 33.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase p450 PF00067.22 CRG86383.1 - 1.6e-26 93.1 0.0 2.2e-26 92.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG86384.1 - 1.5e-30 106.3 37.5 5e-30 104.6 38.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG86384.1 - 5.5e-05 22.6 13.8 0.00033 20.1 4.3 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DNA_pol_A_exo1 PF01612.20 CRG86385.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 3'-5' exonuclease NAD_binding_4 PF07993.12 CRG86386.1 - 1.6e-35 122.5 0.0 2.7e-35 121.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG86386.1 - 7.3e-16 57.8 0.0 1.8e-10 40.0 0.0 2.5 1 1 1 2 2 2 2 AMP-binding enzyme Epimerase PF01370.21 CRG86386.1 - 2.9e-13 49.8 0.0 7.7e-13 48.4 0.0 1.7 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG86386.1 - 2.8e-05 23.7 0.0 7.4e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase PP-binding PF00550.25 CRG86386.1 - 0.00021 21.6 0.0 0.00044 20.6 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CRG86386.1 - 0.037 13.9 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 KR domain 3Beta_HSD PF01073.19 CRG86386.1 - 0.052 12.5 0.0 0.14 11.2 0.0 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Gly-zipper_Omp PF13488.6 CRG86386.1 - 0.057 13.4 2.2 0.13 12.3 2.2 1.5 1 0 0 1 1 1 0 Glycine zipper PQ-loop PF04193.14 CRG86387.1 - 6.6e-21 73.8 20.4 2.8e-12 46.2 2.4 3.4 3 1 1 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 CRG86387.1 - 0.033 15.0 1.3 0.055 14.3 0.4 1.8 1 1 0 1 1 1 0 ER lumen protein retaining receptor DUF1673 PF07895.11 CRG86387.1 - 0.075 12.7 3.7 0.034 13.8 0.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) SLATT_fungal PF18142.1 CRG86387.1 - 0.085 12.8 3.7 0.17 11.9 3.7 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain DUF4231 PF14015.6 CRG86387.1 - 3.7 8.1 8.7 2.1 8.9 3.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) Ish1 PF10281.9 CRG86388.1 - 2.7e-81 267.5 27.6 2.5e-14 53.3 0.0 8.6 8 0 0 8 8 8 7 Putative stress-responsive nuclear envelope protein SAP PF02037.27 CRG86388.1 - 1e-08 34.7 0.0 2.7 7.8 0.0 5.9 5 1 0 5 5 5 3 SAP domain HeH PF12949.7 CRG86388.1 - 3.4e-06 26.7 12.7 0.069 12.9 0.2 5.9 8 0 0 8 8 7 3 HeH/LEM domain Slx4 PF09494.10 CRG86388.1 - 0.00028 20.8 2.8 57 3.8 0.0 6.3 7 0 0 7 7 7 0 Slx4 endonuclease SAP30_Sin3_bdg PF13867.6 CRG86388.1 - 0.0096 16.2 6.3 2.3 8.6 0.2 4.8 5 0 0 5 5 5 1 Sin3 binding region of histone deacetylase complex subunit SAP30 Thymopoietin PF08198.11 CRG86388.1 - 0.046 13.3 0.2 41 3.9 0.0 3.4 3 0 0 3 3 3 0 Thymopoietin protein Recombinase PF07508.13 CRG86388.1 - 0.086 13.3 2.5 1.2 9.6 0.5 3.4 3 1 0 3 3 2 0 Recombinase Phage_int_SAM_1 PF02899.17 CRG86388.1 - 0.34 11.2 4.5 20 5.6 0.2 3.7 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Caudo_TAP PF02413.17 CRG86388.1 - 0.56 10.3 6.6 0.61 10.2 0.7 2.9 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK ArfGap PF01412.18 CRG86388.1 - 2.5 8.2 4.5 40 4.3 0.1 3.4 2 1 2 4 4 4 0 Putative GTPase activating protein for Arf SAM_2 PF07647.17 CRG86388.1 - 2.9 8.1 5.2 1.6e+02 2.5 0.4 4.9 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) Shadoo PF14999.6 CRG86388.1 - 3.3 7.8 8.3 2.9 8.0 1.0 3.1 3 0 0 3 3 3 0 Shadow of prion protein, neuroprotective DFRP_C PF16543.5 CRG86388.1 - 3.7 8.1 5.9 1.7 9.2 2.2 2.5 2 1 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 DUF1517 PF07466.11 CRG86388.1 - 7.4 6.6 10.5 1.2 9.3 0.8 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1517) Cyt-b5 PF00173.28 CRG86389.1 - 6.4e-14 51.8 0.0 8e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DHR10 PF18595.1 CRG86390.1 - 3.5 7.7 13.2 0.04 14.0 1.9 2.4 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain WXG100 PF06013.12 CRG86390.1 - 4.2 7.7 6.9 14 6.0 0.1 2.9 2 2 0 2 2 2 0 Proteins of 100 residues with WXG TMA7 PF09072.10 CRG86391.1 - 1.4e-25 89.8 18.2 1.6e-25 89.7 18.2 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Pkinase PF00069.25 CRG86392.1 - 8e-53 179.5 0.0 1.1e-52 179.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86392.1 - 3.4e-22 79.0 0.0 1.3e-21 77.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CRG86392.1 - 0.089 12.7 2.5 0.45 10.4 0.1 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase PF00069.25 CRG86393.1 - 3.7e-50 170.7 0.0 4.8e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86393.1 - 1.5e-32 112.9 0.0 1.8e-32 112.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CRG86393.1 - 0.0029 17.6 0.0 0.006 16.5 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG86393.1 - 0.021 14.2 0.0 0.032 13.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CRG86393.1 - 0.12 12.0 0.0 0.85 9.2 0.0 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 CRG86393.1 - 0.19 10.6 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 CRG86393.1 - 0.25 10.9 0.0 0.4 10.2 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase adh_short_C2 PF13561.6 CRG86394.1 - 2.7e-49 167.9 7.5 2.4e-39 135.3 7.9 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86394.1 - 4.4e-44 150.3 5.2 5.5e-44 150.0 5.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86394.1 - 1.2e-14 54.7 0.7 1.6e-14 54.2 0.7 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CRG86394.1 - 0.00039 20.3 1.2 0.0008 19.3 1.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG86394.1 - 0.0035 16.5 0.0 0.0054 15.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.19 CRG86394.1 - 0.02 14.3 0.1 0.033 13.5 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 CRG86394.1 - 0.041 13.9 0.3 0.074 13.1 0.3 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.20 CRG86394.1 - 0.042 13.9 0.1 0.076 13.1 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ADH_zinc_N PF00107.26 CRG86394.1 - 0.049 13.6 3.4 0.22 11.5 1.9 2.4 2 0 0 2 2 2 0 Zinc-binding dehydrogenase UDPG_MGDP_dh_N PF03721.14 CRG86394.1 - 0.054 13.1 0.1 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_RFF PF18321.1 CRG86394.1 - 0.43 11.0 5.3 0.84 10.1 2.5 2.3 2 0 0 2 2 2 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain HlyIII PF03006.20 CRG86397.1 - 1.4e-62 211.4 12.9 1.6e-62 211.2 12.9 1.0 1 0 0 1 1 1 1 Haemolysin-III related SAC3_GANP PF03399.16 CRG86398.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CRG86398.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family TPR_19 PF14559.6 CRG86399.1 - 3e-08 34.0 0.0 0.00088 19.7 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG86399.1 - 0.0015 18.5 0.0 1.2 9.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CRG86399.1 - 0.022 15.3 1.0 4.3 8.2 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 CRG86399.1 - 0.033 14.5 0.1 0.81 10.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 CRG86399.1 - 0.16 12.3 0.0 27 5.3 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Glycos_transf_2 PF00535.26 CRG86400.1 - 4.9e-34 117.6 0.0 5.9e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CRG86400.1 - 5.2e-13 49.4 0.0 6.5e-13 49.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CRG86400.1 - 8.7e-06 25.4 0.0 1.1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 CRG86400.1 - 3.1e-05 23.5 0.0 4.7e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glyco_trans_2_3 PF13632.6 CRG86400.1 - 0.0037 17.2 0.0 0.0053 16.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 DUF1749 PF08538.10 CRG86401.1 - 1.3e-97 326.6 0.0 1.6e-97 326.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 CRG86401.1 - 0.00079 20.1 0.1 0.0011 19.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG86401.1 - 0.034 13.4 0.0 0.16 11.2 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 CRG86401.1 - 0.17 11.4 0.3 2.1 7.8 0.0 2.3 2 1 0 2 2 2 0 Lipid-droplet associated hydrolase Zn_clus PF00172.18 CRG86402.1 - 5.2e-07 29.7 8.8 5.2e-07 29.7 8.8 2.1 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain E7 PF00527.18 CRG86402.1 - 0.076 13.2 0.3 0.21 11.8 0.3 1.7 1 0 0 1 1 1 0 E7 protein, Early protein TackOD1 PF18551.1 CRG86402.1 - 0.33 10.6 9.8 0.38 10.4 0.3 2.2 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 Dicty_REP PF05086.12 CRG86403.1 - 1.3 6.9 12.0 1.5 6.7 12.0 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ANAPC4_WD40 PF12894.7 CRG86404.1 - 0.072 13.4 0.4 36 4.7 0.0 3.8 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain DUF1754 PF08555.10 CRG86404.1 - 6.3 7.7 20.4 13 6.6 11.6 2.8 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) NST1 PF13945.6 CRG86406.1 - 2.3e-65 220.3 3.9 2.3e-65 220.3 3.9 4.0 2 2 2 4 4 4 1 Salt tolerance down-regulator Vps35 PF03635.17 CRG86407.1 - 0 1029.0 7.5 0 1028.8 7.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 ATP-synt_E PF05680.12 CRG86407.1 - 7.2 7.0 10.2 15 6.0 9.2 2.0 2 0 0 2 2 2 0 ATP synthase E chain Ras PF00071.22 CRG86408.1 - 6.7e-48 162.3 0.0 7.9e-48 162.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG86408.1 - 9.1e-22 77.5 0.0 1.3e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG86408.1 - 5.1e-06 26.0 0.0 7.8e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CRG86408.1 - 0.012 15.0 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CRG86408.1 - 0.021 14.2 0.0 0.042 13.3 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 CRG86408.1 - 0.1 12.4 0.0 2.6 7.8 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 CRG86408.1 - 0.21 11.3 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MRP-L28 PF09812.9 CRG86409.1 - 2.2e-06 27.9 0.0 2.9e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 adh_short PF00106.25 CRG86411.1 - 1.7e-26 92.9 0.0 5.9e-23 81.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86411.1 - 2.5e-13 50.2 0.0 9.4e-13 48.3 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86411.1 - 6.9e-10 39.1 0.1 9.9e-10 38.6 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG86411.1 - 0.00018 21.1 0.0 0.00033 20.2 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG86411.1 - 0.00054 19.5 0.0 0.002 17.6 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG86411.1 - 0.051 13.5 0.0 0.098 12.5 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding DUF3425 PF11905.8 CRG86412.1 - 5.3e-20 71.7 0.0 1.4e-19 70.2 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) RINGv PF12906.7 CRG86413.1 - 1.8e-05 24.8 7.8 3.3e-05 23.9 7.8 1.5 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 CRG86413.1 - 4.5e-05 23.6 3.5 8.8e-05 22.6 3.5 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 CRG86413.1 - 0.033 14.5 6.4 0.066 13.5 6.4 1.6 1 0 0 1 1 1 0 Ring finger domain CAP_N PF01213.19 CRG86413.1 - 0.042 13.3 1.2 0.082 12.4 1.2 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CHZ PF09649.10 CRG86413.1 - 0.26 10.8 0.7 6.5 6.3 0.4 2.5 2 0 0 2 2 2 0 Histone chaperone domain CHZ TPP_enzyme_N PF02776.18 CRG86414.1 - 9e-55 184.9 0.1 1.1e-53 181.3 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG86414.1 - 7e-51 172.0 0.6 7.1e-49 165.5 0.1 2.8 3 1 0 3 3 3 2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG86414.1 - 4.8e-39 133.2 0.1 1e-38 132.1 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain GalKase_gal_bdg PF10509.9 CRG86415.1 - 3.5e-21 74.5 0.0 6.2e-21 73.7 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 CRG86415.1 - 5.6e-14 52.3 0.0 1.9e-13 50.6 0.0 1.9 2 0 0 2 2 2 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 CRG86415.1 - 5.7e-14 52.1 1.2 5.7e-14 52.1 1.2 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain HTH_3 PF01381.22 CRG86415.1 - 0.044 13.9 0.1 9.3 6.4 0.0 2.8 2 0 0 2 2 2 0 Helix-turn-helix RNase_H2-Ydr279 PF09468.10 CRG86416.1 - 3.4e-41 141.1 0.9 1.5e-40 139.0 0.9 2.1 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 CRG86416.1 - 2.8e-19 69.1 0.0 6.7e-19 67.9 0.0 1.7 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RAI16-like PF10257.9 CRG86416.1 - 0.014 14.3 0.0 0.022 13.6 0.0 1.3 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein DUF3306 PF11748.8 CRG86416.1 - 0.16 12.9 0.2 0.16 12.9 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3306) zf-primase PF09329.11 CRG86417.1 - 5.7e-18 64.5 2.3 9.7e-18 63.7 2.3 1.4 1 0 0 1 1 1 1 Primase zinc finger DUF1199 PF06712.11 CRG86418.1 - 0.12 12.4 0.1 0.36 10.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1199) DASH_Duo1 PF08651.10 CRG86419.1 - 2.2e-30 104.2 1.1 5.2e-30 103.0 1.1 1.7 1 0 0 1 1 1 1 DASH complex subunit Duo1 Halogen_Hydrol PF10112.9 CRG86419.1 - 0.24 11.4 1.7 0.46 10.5 0.0 2.1 2 1 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DASH_Dad2 PF08654.10 CRG86419.1 - 0.58 10.6 8.5 1.3 9.5 5.5 2.7 2 1 0 2 2 2 0 DASH complex subunit Dad2 FCH PF00611.23 CRG86420.1 - 1.2e-14 54.4 0.0 3.4e-14 52.9 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 CRG86420.1 - 1.2e-11 44.1 0.0 2.7e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG86420.1 - 2.1e-11 43.5 0.3 5.4e-11 42.2 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CRG86420.1 - 1.1e-10 41.1 0.0 2.6e-09 36.6 0.0 2.4 2 0 0 2 2 2 1 Variant SH3 domain Rapsyn_N PF10579.9 CRG86420.1 - 0.083 13.0 0.1 0.18 11.9 0.1 1.6 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region Not1 PF04054.15 CRG86421.1 - 2.2e-140 467.7 0.7 7.4e-140 466.0 0.1 2.2 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 CRG86421.1 - 3.5e-96 321.0 3.2 8.9e-96 319.6 3.2 1.7 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Seipin PF06775.14 CRG86421.1 - 6.3e-62 209.2 0.1 1.1e-61 208.4 0.1 1.4 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) DUF3819 PF12842.7 CRG86421.1 - 1.6e-51 174.1 3.3 3.3e-51 173.0 3.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_TTP_bind PF16417.5 CRG86421.1 - 9.9e-41 139.0 0.0 3.4e-40 137.3 0.0 1.9 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 CRG86421.1 - 1.8e-25 89.8 0.1 5.1e-25 88.3 0.1 1.9 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat TTL PF03133.15 CRG86422.1 - 1.2e-57 195.3 0.0 1.8e-57 194.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 CRG86422.1 - 1.2e-50 172.0 0.0 1.8e-50 171.4 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 CRG86422.1 - 0.0011 18.3 0.0 0.003 16.8 0.0 1.7 2 0 0 2 2 2 1 YheC/D like ATP-grasp Glyco_trans_4_4 PF13579.6 CRG86422.1 - 0.0049 17.3 0.0 0.011 16.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain ABC_tran PF00005.27 CRG86423.1 - 1.3e-37 129.4 0.0 5.2e-36 124.2 0.0 2.4 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CRG86423.1 - 1.3e-21 77.5 6.3 2.2e-21 76.8 6.3 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_22 PF13401.6 CRG86423.1 - 0.00012 22.3 0.1 0.00063 20.0 0.1 2.2 2 1 0 2 2 2 1 AAA domain SMC_N PF02463.19 CRG86423.1 - 0.00033 20.2 0.0 0.013 14.9 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG86423.1 - 0.0047 17.3 0.1 0.01 16.2 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 CRG86423.1 - 0.0062 16.4 0.0 0.012 15.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_30 PF13604.6 CRG86423.1 - 0.0076 16.0 0.1 0.022 14.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CRG86423.1 - 0.011 15.7 0.0 0.14 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 CRG86423.1 - 0.012 15.7 0.2 1.3 9.1 0.0 3.0 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 CRG86423.1 - 0.015 15.1 0.1 0.036 13.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 CRG86423.1 - 0.024 15.1 0.3 0.23 11.9 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 CRG86423.1 - 0.024 14.4 0.5 0.1 12.3 0.5 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_29 PF13555.6 CRG86423.1 - 0.025 14.3 0.0 0.081 12.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG86423.1 - 0.027 15.0 0.0 0.06 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CRG86423.1 - 0.033 14.1 0.1 0.11 12.4 0.0 1.9 3 0 0 3 3 2 0 Adenylylsulphate kinase G-alpha PF00503.20 CRG86423.1 - 0.034 13.3 0.0 0.071 12.2 0.0 1.6 1 0 0 1 1 1 0 G-protein alpha subunit Pox_A32 PF04665.12 CRG86423.1 - 0.057 12.9 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Zeta_toxin PF06414.12 CRG86423.1 - 0.061 12.6 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin T2SSE PF00437.20 CRG86423.1 - 0.082 11.9 0.0 0.19 10.7 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_15 PF13175.6 CRG86423.1 - 0.095 12.4 0.1 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 CRG86423.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CRG86423.1 - 0.17 11.9 0.0 0.4 10.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DDRGK PF09756.9 CRG86424.1 - 0.17 11.4 0.1 0.17 11.4 0.1 3.1 3 0 0 3 3 3 0 DDRGK domain Pex14_N PF04695.13 CRG86425.1 - 2.1e-21 77.2 0.7 2.1e-21 77.2 0.7 2.7 1 1 1 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Baculo_PEP_C PF04513.12 CRG86425.1 - 0.0005 20.1 1.3 0.75 9.8 0.2 2.2 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus zf-C4H2 PF10146.9 CRG86425.1 - 0.0011 19.3 1.8 0.002 18.5 1.5 1.6 1 1 0 1 1 1 1 Zinc finger-containing protein Golgin_A5 PF09787.9 CRG86425.1 - 0.0054 16.2 2.2 0.0081 15.7 2.2 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 DUF1043 PF06295.12 CRG86425.1 - 0.038 14.0 1.0 0.077 13.0 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Nucleo_P87 PF07267.11 CRG86425.1 - 0.04 12.8 3.3 0.048 12.5 3.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Myosin_tail_1 PF01576.19 CRG86425.1 - 0.045 11.6 11.6 0.24 9.2 11.6 1.8 1 1 0 1 1 1 0 Myosin tail FUSC PF04632.12 CRG86425.1 - 0.051 12.1 0.7 0.062 11.8 0.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Spc7 PF08317.11 CRG86425.1 - 0.07 12.0 2.1 0.11 11.3 2.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 CRG86425.1 - 0.088 10.3 7.4 0.11 9.9 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF1664 PF07889.12 CRG86425.1 - 0.091 12.8 2.8 0.15 12.1 1.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 CRG86425.1 - 0.11 12.7 0.5 0.23 11.6 0.3 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TRADD_N PF09034.10 CRG86425.1 - 0.19 11.8 0.9 0.34 11.0 0.9 1.4 1 0 0 1 1 1 0 TRADD, N-terminal domain DUF4407 PF14362.6 CRG86425.1 - 0.2 11.0 2.7 0.26 10.6 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 CRG86425.1 - 0.34 8.8 0.2 0.39 8.6 0.2 1.1 1 0 0 1 1 1 0 Prominin Csm1_N PF18504.1 CRG86425.1 - 0.37 11.2 4.7 1.2 9.5 1.3 2.6 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF4239 PF14023.6 CRG86425.1 - 0.48 10.1 1.5 0.66 9.7 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Ndc80_HEC PF03801.13 CRG86426.1 - 6e-60 201.3 0.1 1.3e-59 200.2 0.1 1.6 1 0 0 1 1 1 1 HEC/Ndc80p family DUF16 PF01519.16 CRG86426.1 - 0.002 18.6 4.6 0.002 18.6 4.6 4.3 3 1 1 4 4 4 1 Protein of unknown function DUF16 HMMR_N PF15905.5 CRG86426.1 - 0.0075 15.8 0.8 0.0075 15.8 0.8 3.9 2 1 2 4 4 4 1 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 CRG86426.1 - 0.0081 15.8 43.2 0.04 13.5 20.9 2.9 2 0 0 2 2 2 2 Intermediate filament protein Golgin_A5 PF09787.9 CRG86426.1 - 1.1 8.6 45.2 0.75 9.2 15.6 3.3 2 1 1 3 3 3 0 Golgin subfamily A member 5 DHR10 PF18595.1 CRG86426.1 - 5.4 7.1 45.6 17 5.5 9.2 3.9 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain TPR_MLP1_2 PF07926.12 CRG86426.1 - 5.6 7.0 49.3 0.68 10.0 12.5 4.3 2 2 1 4 4 4 0 TPR/MLP1/MLP2-like protein RTA1 PF04479.13 CRG86428.1 - 7e-57 192.4 13.4 1.3e-56 191.5 13.4 1.4 1 0 0 1 1 1 1 RTA1 like protein Fungal_trans_2 PF11951.8 CRG86428.1 - 0.0096 14.8 0.9 0.021 13.6 0.9 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_3_C PF01915.22 CRG86429.1 - 2.8e-49 167.9 0.0 8.1e-49 166.3 0.0 1.8 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG86429.1 - 6.6e-37 127.6 0.0 1.1e-36 126.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG86429.1 - 9e-25 86.6 0.0 2.3e-24 85.3 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_transf_28 PF03033.20 CRG86430.1 - 1.5e-22 80.2 0.0 3.3e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain VPS13_C PF16909.5 CRG86430.1 - 0.00076 19.3 0.5 0.0016 18.2 0.5 1.5 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal UDPGT PF00201.18 CRG86430.1 - 0.029 13.2 0.0 0.048 12.4 0.0 1.3 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase ATG_C PF09333.11 CRG86430.1 - 0.037 14.4 0.1 0.23 11.8 0.0 2.3 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain TetR_C_10 PF16295.5 CRG86430.1 - 0.063 13.6 0.0 3.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Glyoxalase PF00903.25 CRG86431.1 - 1e-07 32.2 0.0 1.7e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FAD_binding_3 PF01494.19 CRG86432.1 - 3.6e-58 197.5 0.0 5.4e-58 196.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Fungal_trans PF04082.18 CRG86432.1 - 2.3e-13 49.8 0.9 4.6e-13 48.8 0.9 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugarporin_N PF11471.8 CRG86432.1 - 0.041 13.8 1.1 0.12 12.4 1.1 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Fungal_trans PF04082.18 CRG86433.1 - 8.1e-18 64.4 2.1 1.5e-17 63.6 2.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MID_MedPIWI PF18296.1 CRG86433.1 - 0.077 12.8 1.8 0.17 11.7 1.8 1.4 1 0 0 1 1 1 0 MID domain of medPIWI OxoGdeHyase_C PF16870.5 CRG86433.1 - 0.11 12.1 0.1 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 2-oxoglutarate dehydrogenase C-terminal Pkinase PF00069.25 CRG86434.1 - 2.8e-67 226.8 0.0 3.8e-67 226.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86434.1 - 3e-29 102.1 0.0 4.5e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG86434.1 - 0.021 13.8 0.2 0.033 13.2 0.2 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_C PF00433.24 CRG86434.1 - 0.027 15.2 0.6 0.084 13.6 0.6 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain Pkinase_fungal PF17667.1 CRG86434.1 - 0.061 12.1 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 CRG86434.1 - 0.12 12.0 0.0 2.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 FolB PF02152.18 CRG86435.1 - 6.2e-28 97.6 0.0 5.4e-21 75.2 0.3 2.4 2 0 0 2 2 2 2 Dihydroneopterin aldolase RRM_1 PF00076.22 CRG86436.1 - 1.4e-19 69.7 0.0 1e-09 38.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CRG86436.1 - 0.049 13.7 0.0 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 RNA binding motif RRM_occluded PF16842.5 CRG86436.1 - 0.17 11.7 0.0 0.43 10.5 0.0 1.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif Vps54 PF07928.12 CRG86438.1 - 2.4e-08 34.5 0.0 3.1e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Vps54-like protein Glucosamine_iso PF01182.20 CRG86439.1 - 1.3e-69 234.5 0.0 1.5e-69 234.3 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase RRM_1 PF00076.22 CRG86440.1 - 1.8e-09 37.3 0.0 0.005 16.6 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SPX PF03105.19 CRG86440.1 - 0.31 10.9 8.3 0.43 10.5 8.3 1.4 1 0 0 1 1 1 0 SPX domain MA3 PF02847.17 CRG86441.1 - 5.2e-28 97.3 0.1 1.4e-27 95.9 0.0 1.8 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 CRG86441.1 - 3.8e-12 46.3 0.1 7.3e-12 45.4 0.1 1.5 1 0 0 1 1 1 1 MIF4G domain DPM2 PF07297.12 CRG86442.1 - 1.3e-29 102.3 1.2 1.5e-29 102.1 1.2 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4229 PF14012.6 CRG86442.1 - 0.00087 19.3 2.0 0.0011 19.0 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) PIG-P PF08510.12 CRG86442.1 - 0.0051 16.7 0.7 0.0056 16.6 0.7 1.1 1 0 0 1 1 1 1 PIG-P LapA_dom PF06305.11 CRG86442.1 - 0.02 14.7 0.1 0.035 13.9 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain COX14 PF14880.6 CRG86442.1 - 0.06 13.2 0.8 0.45 10.4 0.1 2.0 2 0 0 2 2 2 0 Cytochrome oxidase c assembly ANAPC4_WD40 PF12894.7 CRG86443.1 - 0.11 12.8 0.0 72 3.8 0.0 3.6 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain HD PF01966.22 CRG86444.1 - 0.00017 21.8 2.5 0.00046 20.4 0.6 2.2 2 0 0 2 2 2 1 HD domain RMI1_C PF16099.5 CRG86444.1 - 0.014 15.2 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Recq-mediated genome instability protein 1, C-terminal OB-fold PALP PF00291.25 CRG86445.1 - 3.3e-41 141.6 0.1 3.6e-41 141.5 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Fungal_trans PF04082.18 CRG86446.1 - 1.1e-22 80.4 0.0 1.7e-22 79.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86446.1 - 9.2e-07 28.9 6.7 1.9e-06 27.9 6.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HSA PF07529.13 CRG86446.1 - 0.034 14.5 0.0 0.088 13.1 0.0 1.6 1 0 0 1 1 1 0 HSA PRAP PF15314.6 CRG86446.1 - 0.17 12.4 1.6 0.22 12.0 0.1 1.9 2 0 0 2 2 2 0 Proline-rich acidic protein 1, pregnancy-specific uterine YwcE PF17368.2 CRG86446.1 - 0.22 12.2 0.0 0.45 11.2 0.0 1.4 1 0 0 1 1 1 0 Spore morphogenesis and germination YwcE SOG2 PF10428.9 CRG86447.1 - 8.7 5.4 10.8 10 5.2 10.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein ResIII PF04851.15 CRG86448.1 - 5.2e-21 75.4 0.0 9.7e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG86448.1 - 3.3e-19 69.3 0.1 1e-18 67.7 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG86448.1 - 2.4e-16 60.0 0.0 7.3e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 CRG86448.1 - 0.0043 16.7 0.0 0.0076 15.9 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase UIM PF02809.20 CRG86448.1 - 0.028 14.3 1.1 0.11 12.4 1.1 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif NACHT PF05729.12 CRG86448.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain OAD_gamma PF04277.13 CRG86448.1 - 3.6 8.2 6.7 3.1 8.5 0.0 3.3 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain F_actin_cap_B PF01115.17 CRG86449.1 - 6e-106 353.4 0.0 7.1e-106 353.2 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Med11 PF10280.9 CRG86450.1 - 3.2e-43 147.5 0.0 4.2e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Mediator complex protein WD40 PF00400.32 CRG86451.1 - 1.3e-45 152.4 21.4 5.8e-09 36.4 0.1 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 CRG86451.1 - 4.6e-39 133.6 0.2 6.8e-39 133.1 0.2 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 CRG86451.1 - 1.9e-10 40.9 0.2 0.012 15.9 0.0 5.0 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CRG86451.1 - 6.5e-07 29.1 0.0 1.7e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 LisH Nup160 PF11715.8 CRG86451.1 - 0.0026 16.5 1.3 0.12 10.9 0.0 3.2 3 1 1 4 4 4 1 Nucleoporin Nup120/160 HPS3_N PF14761.6 CRG86451.1 - 0.037 13.6 0.0 0.19 11.3 0.0 2.0 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 DUF4550 PF15084.6 CRG86451.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4550) TPP_enzyme_N PF02776.18 CRG86452.1 - 1.8e-20 73.3 0.4 3.1e-20 72.5 0.4 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG86452.1 - 4.1e-18 65.4 0.0 1.1e-17 64.1 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Abhydrolase_6 PF12697.7 CRG86452.1 - 1.7e-14 54.9 0.7 3.9e-14 53.8 0.7 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family TPP_enzyme_C PF02775.21 CRG86452.1 - 2.7e-12 46.7 0.0 6.9e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Abhydrolase_1 PF00561.20 CRG86452.1 - 0.00021 21.1 0.0 0.00046 19.9 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG86452.1 - 0.0052 16.1 0.0 0.012 14.9 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 CRG86452.1 - 0.048 13.4 0.0 0.097 12.4 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2417 PF10329.9 CRG86454.1 - 2.9e-82 275.6 0.6 4.3e-82 275.1 0.6 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) BPL_N PF09825.9 CRG86454.1 - 2.8e-10 39.8 0.1 5.3e-08 32.3 0.1 2.2 2 0 0 2 2 2 2 Biotin-protein ligase, N terminal GATase_3 PF07685.14 CRG86454.1 - 0.1 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain ThuA PF06283.11 CRG86454.1 - 0.11 12.7 0.0 0.27 11.4 0.0 1.7 2 0 0 2 2 2 0 Trehalose utilisation FA_desaturase PF00487.24 CRG86454.1 - 1.7 8.4 5.1 4 7.2 5.1 1.6 1 0 0 1 1 1 0 Fatty acid desaturase Trp_oprn_chp PF09534.10 CRG86454.1 - 2.1 8.1 10.1 0.86 9.4 7.3 1.7 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) NPL4 PF05021.15 CRG86455.1 - 5.5e-137 456.2 0.0 6.7e-137 455.9 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 CRG86455.1 - 8.6e-70 233.5 0.0 1.3e-69 232.9 0.0 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 CRG86455.1 - 0.0065 16.9 0.0 0.048 14.1 0.0 2.4 2 1 0 2 2 2 1 Nuclear pore localisation protein NPL4 Flavodoxin_2 PF02525.17 CRG86456.1 - 1.1e-07 31.7 0.0 1.4e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 CRG86456.1 - 9.6e-07 28.7 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 CRG86456.1 - 4.7e-05 23.6 0.1 0.0044 17.2 0.1 2.5 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 CRG86456.1 - 0.014 15.6 0.0 0.032 14.5 0.0 1.5 1 1 0 1 1 1 0 Flavodoxin domain zf-CCCH PF00642.24 CRG86457.1 - 5.8e-17 61.2 33.9 5.5e-07 29.3 2.1 5.4 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CRG86457.1 - 5.2e-11 43.2 26.8 7.6e-05 23.4 1.4 5.3 1 1 4 5 5 5 5 Torus domain zf_CCCH_4 PF18345.1 CRG86457.1 - 7.9e-10 38.5 34.3 0.001 19.0 2.9 5.2 5 0 0 5 5 5 4 Zinc finger domain zf-CCCH_4 PF18044.1 CRG86457.1 - 7.8e-05 22.4 2.3 7.8e-05 22.4 2.3 4.6 4 0 0 4 4 4 3 CCCH-type zinc finger Glyco_hydro_18 PF00704.28 CRG86458.1 - 7.7e-65 219.6 0.0 1.1e-40 140.3 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolases family 18 DUF3854 PF12965.7 CRG86458.1 - 0.18 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) DUF3712 PF12505.8 CRG86459.1 - 9.3e-31 106.7 0.5 9.3e-31 106.7 0.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) LEA_2 PF03168.13 CRG86459.1 - 0.019 15.5 1.5 0.095 13.2 0.5 2.3 2 0 0 2 2 2 0 Late embryogenesis abundant protein Chordopox_A13L PF05961.11 CRG86459.1 - 0.46 10.8 2.4 1.1 9.6 2.4 1.6 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Sel1 PF08238.12 CRG86460.1 - 1.1e-10 41.8 14.9 0.0014 19.2 0.2 4.4 4 1 0 4 4 4 3 Sel1 repeat Myc_target_1 PF15179.6 CRG86461.1 - 0.69 9.8 3.3 7.8 6.4 0.1 2.2 2 0 0 2 2 2 0 Myc target protein 1 Stevor PF17410.2 CRG86461.1 - 1.6 8.2 4.6 0.31 10.6 0.2 1.8 2 0 0 2 2 2 0 Subtelomeric Variable Open Reading frame DUF1776 PF08643.10 CRG86462.1 - 4.5e-97 325.0 0.0 5.6e-97 324.7 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 CRG86462.1 - 0.011 15.2 0.0 0.75 9.2 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86462.1 - 0.047 13.2 0.0 8.5 5.9 0.0 2.2 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase CoA_binding_3 PF13727.6 CRG86462.1 - 0.14 12.2 0.1 0.29 11.2 0.1 1.4 1 0 0 1 1 1 0 CoA-binding domain WLM PF08325.10 CRG86463.1 - 6.7e-66 222.0 1.1 7.4e-66 221.9 0.2 1.6 2 0 0 2 2 2 1 WLM domain zf-RanBP PF00641.18 CRG86463.1 - 3.6e-07 29.4 22.2 1e-06 27.9 4.6 3.2 2 1 0 2 2 2 1 Zn-finger in Ran binding protein and others DZR PF12773.7 CRG86463.1 - 0.0038 17.2 8.5 0.028 14.4 8.6 2.1 1 1 0 1 1 1 1 Double zinc ribbon DUF45 PF01863.17 CRG86463.1 - 0.034 14.2 2.5 0.034 14.2 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF45 Peptidase_M54 PF07998.11 CRG86463.1 - 0.18 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 zinc_ribbon_15 PF17032.5 CRG86463.1 - 0.47 11.2 5.0 8.3 7.2 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon family C1_2 PF03107.16 CRG86463.1 - 0.67 10.3 6.3 6.6 7.1 0.2 2.6 2 0 0 2 2 2 0 C1 domain HypA PF01155.19 CRG86463.1 - 7 6.7 8.9 5.3e+02 0.7 8.9 2.6 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA WD40 PF00400.32 CRG86464.1 - 2.7e-50 167.2 29.4 4.2e-06 27.4 0.0 11.7 12 0 0 12 12 12 10 WD domain, G-beta repeat Utp12 PF04003.12 CRG86464.1 - 4e-22 78.6 0.1 8.8e-22 77.5 0.1 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 CRG86464.1 - 4.5e-20 71.8 1.3 0.041 14.2 0.0 8.9 5 3 3 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG86464.1 - 8.5e-08 31.5 2.5 0.19 10.6 0.0 5.3 4 2 1 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CRG86464.1 - 0.00019 20.9 0.0 1.1 8.5 0.0 3.7 4 0 0 4 4 4 2 WD40-like domain Frtz PF11768.8 CRG86464.1 - 0.00028 19.4 0.0 0.015 13.6 0.0 2.3 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 CRG86464.1 - 0.0018 17.0 1.0 0.17 10.5 0.0 4.0 5 1 1 6 6 6 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CRG86464.1 - 0.0042 15.9 2.2 12 4.5 0.1 4.5 2 1 0 4 4 4 1 Nup133 N terminal like PALB2_WD40 PF16756.5 CRG86464.1 - 0.052 12.5 1.1 9.3 5.1 0.2 3.1 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain RRP36 PF06102.12 CRG86464.1 - 2.2 8.2 7.2 3.3 7.7 1.0 2.4 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 P34-Arc PF04045.14 CRG86465.1 - 7.6e-108 359.7 0.1 9.2e-108 359.5 0.1 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc ARPC4 PF05856.12 CRG86465.1 - 0.035 13.7 0.0 0.059 13.0 0.0 1.4 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) DUF3328 PF11807.8 CRG86467.1 - 4.9e-15 55.9 8.8 2.7e-14 53.5 7.9 2.0 1 1 0 2 2 2 1 Domain of unknown function (DUF3328) Scytalone_dh PF02982.14 CRG86467.1 - 0.17 11.7 1.3 0.2 11.4 0.1 1.7 2 0 0 2 2 2 0 Scytalone dehydratase Amidohydro_1 PF01979.20 CRG86469.1 - 2.5e-19 69.8 0.0 3.5e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 CRG86469.1 - 9.9e-09 35.2 0.0 1.9e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family Peptidase_A4 PF01828.17 CRG86470.1 - 1.5e-64 217.3 15.4 1.8e-64 217.1 15.4 1.0 1 0 0 1 1 1 1 Peptidase A4 family Zn_clus PF00172.18 CRG86471.1 - 1.3e-08 34.8 9.7 1.3e-08 34.8 9.7 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG86471.1 - 0.00044 19.4 0.5 0.00083 18.5 0.1 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Ring_hydroxyl_A PF00848.19 CRG86472.1 - 2.7e-20 73.2 3.9 2.6e-11 43.9 1.3 2.7 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) Rieske PF00355.26 CRG86472.1 - 4.3e-16 58.6 0.0 8.6e-16 57.7 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Fungal_trans PF04082.18 CRG86472.1 - 3.5e-08 32.8 1.3 2.4e-07 30.1 0.1 2.5 2 1 0 2 2 2 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG86473.1 - 1.1e-24 86.9 0.0 1.9e-18 66.6 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86473.1 - 3.3e-13 49.8 0.0 3.8e-08 33.2 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86473.1 - 3.4e-08 33.6 0.2 5.4e-08 32.9 0.2 1.2 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CRG86473.1 - 0.006 16.6 0.1 0.013 15.5 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 CRG86473.1 - 0.01 15.0 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein TPP_enzyme_C PF02775.21 CRG86473.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain EthD PF07110.11 CRG86474.1 - 5.4e-05 24.3 0.0 0.00077 20.6 0.0 2.0 1 1 0 1 1 1 1 EthD domain MFS_1 PF07690.16 CRG86475.1 - 6.4e-16 58.2 39.0 9.9e-15 54.3 39.0 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily p450 PF00067.22 CRG86476.1 - 8e-69 232.6 0.0 9.7e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 CRG86477.1 - 2.2e-80 270.8 15.9 2.6e-80 270.5 15.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86477.1 - 3.6e-22 78.8 54.2 3.3e-17 62.4 25.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2755 PF10954.8 CRG86477.1 - 0.091 12.7 3.5 0.87 9.5 0.2 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2755) ketoacyl-synt PF00109.26 CRG86478.1 - 1.7e-68 231.0 0.0 3.1e-68 230.1 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG86478.1 - 1.4e-61 207.6 0.2 1.4e-61 207.6 0.2 1.9 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 CRG86478.1 - 3.3e-50 171.4 0.0 5.8e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CRG86478.1 - 3e-45 154.7 0.0 4.4e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CRG86478.1 - 9.7e-39 132.0 0.0 7.1e-38 129.3 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG86478.1 - 1.7e-18 67.1 0.0 7.4e-18 65.0 0.0 2.1 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG86478.1 - 9.4e-18 64.4 2.2 4e-17 62.3 0.1 2.6 2 1 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 CRG86478.1 - 4.6e-15 56.8 0.0 1.7e-14 55.0 0.0 2.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG86478.1 - 9.3e-14 51.5 0.0 3.6e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CRG86478.1 - 2.1e-12 47.1 0.2 6.3e-11 42.3 0.0 2.9 3 1 1 4 4 4 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 CRG86478.1 - 7.8e-07 29.0 2.0 1.9e-06 27.7 2.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 CRG86478.1 - 2.6e-06 27.7 0.7 6.4e-06 26.4 0.7 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CRG86478.1 - 0.0022 17.4 0.0 0.0055 16.1 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain GDP_Man_Dehyd PF16363.5 CRG86478.1 - 0.0071 15.8 0.1 0.012 15.1 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase SAT PF16073.5 CRG86478.1 - 0.014 15.1 0.2 0.11 12.2 0.2 2.1 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Polysacc_synt_2 PF02719.15 CRG86478.1 - 0.082 12.0 0.2 0.18 10.9 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein AlaDh_PNT_C PF01262.21 CRG86478.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FSH1 PF03959.13 CRG86479.1 - 6.3e-24 84.8 0.0 1e-23 84.1 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Sugar_tr PF00083.24 CRG86480.1 - 1.3e-109 367.1 21.5 1.6e-109 366.8 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86480.1 - 8.6e-25 87.4 20.5 8.6e-25 87.4 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PIRT PF15099.6 CRG86480.1 - 0.01 15.4 4.5 1.4 8.5 0.4 2.4 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family PHO4 PF01384.20 CRG86481.1 - 6.7e-91 304.8 9.8 3e-89 299.4 9.8 2.1 1 1 0 1 1 1 1 Phosphate transporter family Aldedh PF00171.22 CRG86482.1 - 3.4e-130 434.7 0.1 3.8e-130 434.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Folliculin_C PF16692.5 CRG86482.1 - 0.036 13.8 0.0 0.067 12.9 0.0 1.4 1 0 0 1 1 1 0 Folliculin C-terminal domain Abhydrolase_3 PF07859.13 CRG86483.1 - 2.4e-20 73.3 0.0 1.5e-15 57.7 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG86483.1 - 1.3e-09 37.8 0.1 9.1e-05 22.0 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.28 CRG86483.1 - 1.8e-07 30.4 0.0 3.6e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Carboxylesterase family DLH PF01738.18 CRG86483.1 - 9.4e-06 25.3 0.0 0.025 14.1 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 CRG86483.1 - 4.2e-05 22.6 0.0 6.3e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 CRG86483.1 - 0.0074 16.1 0.0 0.48 10.2 0.0 2.7 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Say1_Mug180 PF10340.9 CRG86483.1 - 0.027 13.3 0.0 1.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Steryl acetyl hydrolase AXE1 PF05448.12 CRG86483.1 - 0.04 12.6 0.0 0.43 9.2 0.0 2.2 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) NmrA PF05368.13 CRG86484.1 - 7.8e-21 74.7 0.0 1.4e-20 73.9 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG86484.1 - 1.2e-13 51.3 0.0 2.5e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Fungal_trans PF04082.18 CRG86484.1 - 1.5e-08 34.0 0.0 2.7e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86484.1 - 0.00022 21.3 6.8 0.00037 20.5 6.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AMP-binding PF00501.28 CRG86485.1 - 3.6e-36 124.7 0.0 7.3e-36 123.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CRG86485.1 - 1.5e-21 76.8 0.0 2.7e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 CRG86485.1 - 3.2e-08 33.3 0.0 4.9e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG86485.1 - 1.6e-05 25.2 0.0 4.6e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CRG86485.1 - 0.017 15.0 0.1 0.11 12.4 0.0 2.3 2 1 0 2 2 2 0 KR domain ketoacyl-synt PF00109.26 CRG86486.1 - 1.7e-72 244.0 0.0 3.2e-72 243.2 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CRG86486.1 - 2.5e-37 127.5 0.1 1.4e-36 125.1 0.1 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CRG86486.1 - 6.6e-23 81.4 0.0 1.3e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG86486.1 - 1.6e-21 77.1 0.0 1.5e-19 70.7 0.0 2.3 2 0 0 2 2 2 1 Acyl transferase domain Abhydrolase_3 PF07859.13 CRG86486.1 - 7.3e-15 55.4 0.0 2.3e-14 53.8 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold PP-binding PF00550.25 CRG86486.1 - 1.7e-11 44.3 0.6 4.1e-11 43.1 0.6 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site SAT PF16073.5 CRG86486.1 - 4.1e-10 39.8 0.2 4.1e-10 39.8 0.2 3.5 4 1 0 4 4 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Peptidase_S9 PF00326.21 CRG86486.1 - 6.7e-10 38.8 0.1 1.2e-05 24.8 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family KAsynt_C_assoc PF16197.5 CRG86486.1 - 5.4e-08 33.3 0.0 1.8e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 CRG86486.1 - 1.4e-05 25.8 1.0 0.00016 22.4 0.7 2.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thiolase_N PF00108.23 CRG86486.1 - 1.7e-05 24.4 0.4 4e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain DLH PF01738.18 CRG86486.1 - 7e-05 22.5 2.0 0.067 12.7 0.2 3.3 2 1 0 3 3 3 2 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 CRG86486.1 - 0.0044 16.0 0.0 0.0099 14.8 0.0 1.6 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 CRG86486.1 - 0.0057 16.5 0.0 3.3 7.5 0.0 2.7 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CRG86486.1 - 0.02 14.6 0.0 0.7 9.5 0.0 3.2 3 1 0 3 3 3 0 alpha/beta hydrolase fold COesterase PF00135.28 CRG86486.1 - 0.031 13.1 0.0 0.089 11.6 0.0 1.7 2 0 0 2 2 2 0 Carboxylesterase family FSH1 PF03959.13 CRG86486.1 - 0.072 12.7 0.0 1.2 8.7 0.0 2.8 2 1 0 2 2 2 0 Serine hydrolase (FSH1) UbiA PF01040.18 CRG86487.1 - 6.6e-26 91.1 11.8 8.9e-26 90.7 11.8 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family Trp_halogenase PF04820.14 CRG86488.1 - 9.4e-28 97.2 0.2 2.4e-13 49.8 0.2 3.1 1 1 1 2 2 2 2 Tryptophan halogenase FAD_binding_3 PF01494.19 CRG86488.1 - 1.4e-09 37.7 0.0 4.2e-09 36.1 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CRG86488.1 - 5.8e-05 22.6 0.0 7.8e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CRG86488.1 - 0.00033 19.9 0.0 0.00062 19.0 0.0 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CRG86488.1 - 0.00079 19.6 0.1 0.0032 17.7 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG86488.1 - 0.00098 18.4 0.0 0.002 17.4 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG86488.1 - 0.0024 17.0 0.1 0.0041 16.3 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CRG86488.1 - 0.0051 15.6 0.1 0.0088 14.8 0.1 1.3 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 CRG86488.1 - 0.028 14.0 0.1 0.07 12.7 0.1 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase Oxidored_FMN PF00724.20 CRG86490.1 - 2.7e-46 158.4 0.0 3.6e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 CRG86490.1 - 0.00022 20.4 0.3 0.00054 19.2 0.0 1.7 2 0 0 2 2 2 1 Dihydrouridine synthase (Dus) AP_endonuc_2 PF01261.24 CRG86490.1 - 0.0091 15.5 0.1 0.27 10.6 0.0 2.8 2 1 0 2 2 2 1 Xylose isomerase-like TIM barrel ADH_zinc_N PF00107.26 CRG86491.1 - 6.1e-09 35.9 0.2 2e-08 34.3 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG86491.1 - 2.8e-06 27.2 0.4 0.00025 20.9 0.1 2.9 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain p450 PF00067.22 CRG86492.1 - 1.7e-34 119.3 0.0 2.1e-34 119.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_11 PF08241.12 CRG86493.1 - 1.4e-15 57.7 0.0 2.2e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG86493.1 - 4.4e-15 55.9 0.0 6.2e-15 55.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG86493.1 - 2.3e-14 53.9 0.0 3.8e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG86493.1 - 3.1e-11 43.3 0.0 4.7e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG86493.1 - 3.9e-09 37.2 0.0 6.6e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CRG86493.1 - 6e-07 29.0 0.0 7.3e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CRG86493.1 - 2.3e-06 27.1 0.0 3.9e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family TPMT PF05724.11 CRG86493.1 - 0.0002 21.1 0.0 0.00033 20.4 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) PCMT PF01135.19 CRG86493.1 - 0.00061 19.6 0.0 0.0016 18.2 0.0 1.6 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 CRG86493.1 - 0.00093 18.7 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 CRG86493.1 - 0.001 19.1 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 CRG86493.1 - 0.002 17.8 0.0 0.006 16.2 0.0 1.7 2 0 0 2 2 2 1 Nodulation protein S (NodS) MTS PF05175.14 CRG86493.1 - 0.0021 17.6 0.0 0.0043 16.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 CRG86493.1 - 0.018 14.6 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW UPF0146 PF03686.13 CRG86493.1 - 0.035 14.0 0.0 0.062 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_18 PF12847.7 CRG86493.1 - 0.037 14.0 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 CRG86493.1 - 0.068 12.7 0.0 0.26 10.9 0.0 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ADH_zinc_N PF00107.26 CRG86493.1 - 0.075 13.0 0.1 0.77 9.8 0.1 2.2 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Mur_ligase PF01225.25 CRG86493.1 - 0.14 12.5 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, catalytic domain Methyltransf_16 PF10294.9 CRG86493.1 - 0.14 11.9 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Oxidored_FMN PF00724.20 CRG86494.1 - 4.5e-40 137.9 0.0 5.9e-40 137.6 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family adh_short PF00106.25 CRG86495.1 - 2.5e-15 56.4 0.0 4.5e-12 45.8 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CRG86495.1 - 0.00016 21.7 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG86495.1 - 0.00096 18.8 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase p450 PF00067.22 CRG86496.1 - 1.4e-45 155.9 0.0 2e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Allexi_40kDa PF05549.11 CRG86496.1 - 0.056 12.9 0.0 0.084 12.4 0.0 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein AMP-binding PF00501.28 CRG86497.1 - 3e-78 263.3 0.0 5.3e-78 262.5 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 CRG86497.1 - 2.4e-70 237.0 0.0 7.1e-70 235.5 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Condensation PF00668.20 CRG86497.1 - 2.4e-63 214.4 0.0 3.8e-63 213.7 0.0 1.3 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 CRG86497.1 - 4.7e-54 183.0 0.9 3.5e-53 180.2 0.9 2.5 3 0 0 3 3 2 1 KR domain PS-DH PF14765.6 CRG86497.1 - 1.4e-51 175.5 0.0 2.5e-51 174.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG86497.1 - 1.8e-42 146.0 0.6 5.6e-42 144.4 0.0 2.0 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG86497.1 - 5.7e-32 110.2 0.0 1.7e-31 108.7 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG86497.1 - 4.5e-21 75.4 0.0 3.5e-19 69.4 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_4 PF07993.12 CRG86497.1 - 8.1e-17 61.2 0.0 1.1e-15 57.5 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 CRG86497.1 - 8.4e-16 58.1 0.0 3.1e-08 33.8 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_23 PF13489.6 CRG86497.1 - 2.9e-14 53.2 0.0 1e-13 51.4 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG86497.1 - 7.8e-13 48.9 0.0 2.3e-12 47.3 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 CRG86497.1 - 1.2e-12 48.3 0.1 1.5e-11 44.8 0.0 3.1 3 0 0 3 3 1 1 Methyltransferase domain adh_short PF00106.25 CRG86497.1 - 4.2e-12 45.9 1.7 1.4e-11 44.2 1.2 2.2 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86497.1 - 2.6e-10 40.3 0.7 6.5e-10 39.0 0.7 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_11 PF08241.12 CRG86497.1 - 5.2e-10 39.8 0.0 5.9e-09 36.5 0.0 3.1 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG86497.1 - 2.4e-09 37.1 0.0 1e-08 35.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CRG86497.1 - 1.2e-06 28.2 0.0 0.0075 15.8 0.0 2.5 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG86497.1 - 6e-05 22.2 1.4 0.22 10.5 0.1 3.0 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family Ubie_methyltran PF01209.18 CRG86497.1 - 0.00013 21.4 0.0 0.00028 20.3 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 CRG86497.1 - 0.0013 18.1 0.1 0.0031 16.9 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain AMP-binding_C PF13193.6 CRG86497.1 - 0.0031 18.5 0.1 0.017 16.1 0.0 2.5 2 0 0 2 2 1 1 AMP-binding enzyme C-terminal domain DUF938 PF06080.12 CRG86497.1 - 0.0061 16.4 0.0 0.022 14.6 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 CRG86497.1 - 0.016 14.9 0.0 0.046 13.5 0.0 1.7 1 0 0 1 1 1 0 Lysine methyltransferase SAT PF16073.5 CRG86497.1 - 0.041 13.6 0.2 0.17 11.6 0.2 2.0 1 1 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Polysacc_synt_2 PF02719.15 CRG86497.1 - 0.042 13.0 0.2 0.25 10.4 0.1 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RrnaAD PF00398.20 CRG86497.1 - 0.078 12.0 0.0 0.18 10.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase SBP_bac_5 PF00496.22 CRG86497.1 - 0.16 10.9 0.0 0.29 10.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle Fungal_trans PF04082.18 CRG86498.1 - 2.8e-09 36.4 0.1 6.1e-09 35.3 0.1 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG86499.1 - 2.3e-44 151.8 38.6 1.2e-43 149.4 39.7 1.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG86499.1 - 8.3e-10 37.7 25.7 1.7e-09 36.7 25.7 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 CRG86499.1 - 0.013 13.9 15.3 0.0057 15.0 2.9 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family F-box PF00646.33 CRG86501.1 - 0.0038 17.1 0.4 0.0053 16.6 0.4 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG86501.1 - 0.058 13.3 0.6 0.081 12.8 0.6 1.3 1 0 0 1 1 1 0 F-box-like GP44 PF17510.2 CRG86501.1 - 0.11 12.8 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Gene product 44 Lipase_GDSL_2 PF13472.6 CRG86502.1 - 6.3e-15 56.0 0.1 8.9e-15 55.5 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG86502.1 - 1.7e-11 44.5 0.0 2.7e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SKG6 PF08693.10 CRG86502.1 - 6.9e-06 25.4 0.0 1.6e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Lipase_GDSL_3 PF14606.6 CRG86502.1 - 0.0021 18.2 0.0 0.0034 17.5 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family 2-Hacid_dh_C PF02826.19 CRG86503.1 - 1e-44 152.0 0.0 3.6e-43 147.0 0.0 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG86503.1 - 6.1e-10 38.9 0.0 3.4e-08 33.2 0.0 2.1 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 CRG86503.1 - 0.033 14.8 0.0 0.08 13.5 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CRG86503.1 - 0.15 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 4HBT_2 PF13279.6 CRG86504.1 - 3e-07 30.9 0.0 5.3e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF1772 PF08592.11 CRG86504.1 - 1.5e-05 25.3 1.9 3.1e-05 24.3 1.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Svf1_C PF17187.4 CRG86505.1 - 5.7e-56 188.9 0.0 9e-56 188.2 0.0 1.3 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 CRG86505.1 - 1.1e-51 175.2 0.0 1.8e-51 174.4 0.0 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain FMO-like PF00743.19 CRG86506.1 - 1.2e-22 80.1 0.0 4e-08 32.1 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG86506.1 - 3.5e-12 46.2 3.5 7.3e-06 25.5 0.5 3.7 4 0 0 4 4 4 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG86506.1 - 1.5e-09 37.6 1.5 5.5e-07 29.1 1.5 3.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG86506.1 - 1.7e-08 34.0 0.1 0.00049 19.3 0.0 3.9 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CRG86506.1 - 2.6e-07 30.8 0.0 6.7e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG86506.1 - 1.1e-05 25.2 0.2 0.029 13.9 0.0 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG86506.1 - 1.1e-05 25.4 0.4 0.01 15.8 0.0 3.2 3 1 0 3 3 3 2 FAD-NAD(P)-binding Thi4 PF01946.17 CRG86506.1 - 0.0058 15.9 0.1 0.022 14.0 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CRG86506.1 - 0.031 14.8 2.1 1 10.0 0.0 3.4 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG86506.1 - 0.036 13.4 0.0 9.1 5.4 0.0 2.9 3 1 1 4 4 4 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CRG86506.1 - 0.081 11.6 0.0 0.13 10.9 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Cu-oxidase_2 PF07731.14 CRG86507.1 - 1.6e-38 131.5 5.8 1.4e-36 125.3 0.2 3.0 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG86507.1 - 4.2e-38 130.0 1.7 4.2e-38 130.0 1.7 2.7 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG86507.1 - 2e-35 122.3 0.5 1.8e-34 119.2 0.3 2.4 2 0 0 2 2 2 1 Multicopper oxidase Glyco_hydro_61 PF03443.14 CRG86507.1 - 0.034 14.1 0.1 0.085 12.8 0.1 1.6 1 0 0 1 1 1 0 Glycosyl hydrolase family 61 NUDIX PF00293.28 CRG86509.1 - 3.6e-22 78.8 0.1 4.3e-22 78.6 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain DNA_pol_viral_C PF00336.18 CRG86509.1 - 0.24 10.8 0.0 0.79 9.1 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain Glyco_hydro_76 PF03663.14 CRG86510.1 - 1.3e-130 436.2 21.0 1.7e-130 435.9 21.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 adh_short_C2 PF13561.6 CRG86513.1 - 1.8e-58 197.9 0.0 1.4e-57 194.9 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86513.1 - 2.7e-46 157.5 0.1 4.4e-45 153.5 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86513.1 - 9.3e-08 32.2 0.1 2.2e-07 31.0 0.1 1.6 1 1 0 1 1 1 1 KR domain Glyco_hydro_7 PF00840.20 CRG86514.1 - 5.6e-205 681.1 14.8 6.3e-205 680.9 14.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 Fungal_trans PF04082.18 CRG86515.1 - 4.6e-07 29.1 0.5 8e-07 28.4 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 CRG86516.1 - 6.4e-05 22.6 0.0 8.2e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family adh_short_C2 PF13561.6 CRG86517.1 - 4.2e-57 193.4 0.3 4.9e-57 193.2 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86517.1 - 4.2e-42 143.8 0.0 5.2e-42 143.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86517.1 - 3e-07 30.5 0.3 3.9e-07 30.1 0.3 1.1 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 CRG86517.1 - 0.051 13.5 0.1 0.093 12.6 0.1 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus Spherulin4 PF12138.8 CRG86518.1 - 6.1e-52 176.7 5.6 7.4e-52 176.4 5.6 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 Bac_chlorC PF02043.17 CRG86519.1 - 0.04 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein Sugar_tr PF00083.24 CRG86520.1 - 1.6e-109 366.7 26.0 1.9e-109 366.5 26.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86520.1 - 6.4e-22 78.0 49.8 2.2e-18 66.3 24.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_10 PF13374.6 CRG86521.1 - 7e-49 162.5 4.6 3.2e-12 45.9 0.0 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 CRG86521.1 - 1.4e-43 147.0 13.3 6.8e-20 71.1 2.4 3.8 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CRG86521.1 - 8.1e-26 88.7 13.2 2.4e-06 27.1 0.6 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 CRG86521.1 - 2.5e-22 77.2 4.3 1.7e-05 24.5 0.0 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG86521.1 - 1.4e-18 67.4 3.3 3.1e-10 40.0 0.2 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_2 PF07719.17 CRG86521.1 - 2.4e-16 58.5 12.7 0.00031 20.6 1.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG86521.1 - 2.5e-15 55.8 1.9 0.00016 22.2 0.3 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG86521.1 - 3.4e-15 54.9 11.0 0.00079 19.5 0.5 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 CRG86521.1 - 9.9e-10 38.9 6.7 0.088 13.5 0.3 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF2225 PF09986.9 CRG86521.1 - 2.7e-09 37.1 2.7 0.066 12.9 0.0 3.2 1 1 2 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) TPR_17 PF13431.6 CRG86521.1 - 2.1e-07 30.8 7.9 0.54 10.8 0.1 5.1 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 CRG86521.1 - 4.4e-06 27.0 18.5 0.031 14.9 0.8 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF5344 PF17279.2 CRG86521.1 - 2.3e-05 24.9 0.2 16 6.2 0.1 4.1 4 0 0 4 4 4 0 Family of unknown function (DUF5344) TPR_4 PF07721.14 CRG86521.1 - 3.1e-05 24.2 0.0 1.8 9.4 0.1 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat SNAP PF14938.6 CRG86521.1 - 8.1e-05 22.2 0.2 0.00018 21.0 0.3 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 CRG86521.1 - 0.00013 22.0 1.1 7.6 7.0 0.0 4.5 4 0 0 4 4 4 0 PPR repeat TPR_11 PF13414.6 CRG86521.1 - 0.00015 21.3 15.4 0.14 11.9 0.3 4.5 5 0 0 5 5 4 3 TPR repeat TPR_19 PF14559.6 CRG86521.1 - 0.00035 21.0 8.8 0.11 13.0 0.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_21 PF09976.9 CRG86521.1 - 0.0016 18.2 10.3 0.82 9.4 0.3 3.6 2 1 2 4 4 4 2 Tetratricopeptide repeat-like domain 14-3-3 PF00244.20 CRG86521.1 - 0.0023 17.4 1.6 3.7 7.0 0.6 2.9 1 1 2 3 3 3 2 14-3-3 protein ANAPC3 PF12895.7 CRG86521.1 - 0.0025 18.0 2.3 0.77 10.0 0.3 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Wzy_C_2 PF11846.8 CRG86521.1 - 0.0031 17.5 4.5 1.3 8.9 0.0 3.7 2 1 2 4 4 4 1 Virulence factor membrane-bound polymerase, C-terminal DUF4810 PF16068.5 CRG86521.1 - 0.0083 16.7 7.9 5 7.7 0.2 4.1 3 1 0 4 4 4 1 Domain of unknown function (DUF4810) ComR_TPR PF18710.1 CRG86521.1 - 0.0091 15.6 0.6 0.053 13.1 0.1 2.2 3 0 0 3 3 2 1 ComR tetratricopeptide Mad3_BUB1_I PF08311.12 CRG86521.1 - 0.025 14.6 2.6 54 3.8 0.1 4.1 4 0 0 4 4 4 0 Mad3/BUB1 homology region 1 Tcf25 PF04910.14 CRG86521.1 - 0.028 13.5 0.0 7.6 5.5 0.0 2.7 2 1 2 4 4 4 0 Transcriptional repressor TCF25 RPN6_N PF18055.1 CRG86521.1 - 0.029 14.7 4.0 0.73 10.2 0.6 3.2 1 1 3 4 4 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain TPR_15 PF13429.6 CRG86521.1 - 0.06 12.6 4.7 6.5 5.9 0.0 3.3 3 1 0 4 4 4 0 Tetratricopeptide repeat Ubiq_cyt_C_chap PF03981.12 CRG86521.1 - 0.12 12.4 1.6 13 5.9 0.2 2.7 1 1 2 3 3 3 0 Ubiquinol-cytochrome C chaperone MIT PF04212.18 CRG86521.1 - 0.14 12.3 4.5 33 4.6 0.0 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF1024 PF06260.12 CRG86521.1 - 0.55 10.6 3.0 16 5.9 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1024) TPR_3 PF07720.12 CRG86521.1 - 0.94 9.5 6.1 4.3 7.4 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CysG_dimeriser PF10414.9 CRG86521.1 - 2.1 8.1 6.5 67 3.3 0.0 3.9 4 0 0 4 4 4 0 Sirohaem synthase dimerisation region DUF1897 PF09005.10 CRG86521.1 - 2.5 7.7 11.3 2.6 7.6 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1897) Pribosyltran_N PF13793.6 CRG86522.1 - 1.1e-42 144.7 0.5 2.4e-42 143.5 0.1 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CRG86522.1 - 7.6e-42 143.4 0.8 7.1e-36 124.0 0.1 2.7 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CRG86522.1 - 1.1e-15 57.5 0.5 2.3e-15 56.5 0.5 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CRG86522.1 - 0.0014 18.1 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase S-methyl_trans PF02574.16 CRG86523.1 - 7.9e-39 134.1 0.0 9.6e-39 133.8 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase HpcH_HpaI PF03328.14 CRG86524.1 - 3.7e-34 117.8 0.0 4.9e-34 117.4 0.0 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family MFS_1 PF07690.16 CRG86526.1 - 3.4e-27 95.3 63.4 3.2e-21 75.6 31.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Zn_clus PF00172.18 CRG86527.1 - 3.5e-07 30.2 7.7 3.5e-07 30.2 7.7 2.6 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TUDOR PF00567.24 CRG86527.1 - 0.056 13.5 0.0 0.55 10.3 0.0 2.3 2 0 0 2 2 2 0 Tudor domain ketoacyl-synt PF00109.26 CRG86530.1 - 1.6e-73 247.4 0.3 3.2e-73 246.4 0.1 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG86530.1 - 5.1e-44 150.3 0.0 1.1e-43 149.3 0.0 1.6 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CRG86530.1 - 1.4e-41 142.7 0.0 2.3e-41 142.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG86530.1 - 3e-40 138.7 0.0 1.3e-39 136.6 0.0 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG86530.1 - 2.7e-31 108.0 0.0 5.6e-31 107.0 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG86530.1 - 2.6e-14 53.6 0.0 8.5e-14 52.0 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG86530.1 - 2.2e-11 43.6 0.0 5e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase PP-binding PF00550.25 CRG86530.1 - 1.9e-06 28.1 0.1 6.5e-06 26.4 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 CRG86530.1 - 0.0003 21.5 0.2 0.0025 18.5 0.0 2.8 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG86530.1 - 0.0016 19.1 0.0 0.0057 17.3 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG86530.1 - 0.0057 16.5 0.0 0.03 14.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain SAT PF16073.5 CRG86530.1 - 0.055 13.2 0.0 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Epimerase PF01370.21 CRG86530.1 - 0.18 11.2 0.0 1.8 7.9 0.0 2.2 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Thiolase_N PF00108.23 CRG86530.1 - 0.18 11.1 0.3 0.44 9.9 0.3 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain PAPS_reduct PF01507.19 CRG86531.1 - 8.9e-08 32.4 0.0 2e-05 24.7 0.0 2.6 1 1 1 2 2 2 1 Phosphoadenosine phosphosulfate reductase family AMP-binding PF00501.28 CRG86532.1 - 5.5e-69 232.8 0.0 7.4e-69 232.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG86532.1 - 2.4e-15 57.3 0.0 4.5e-15 56.4 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain SBF PF01758.16 CRG86533.1 - 1.1e-47 162.3 7.4 1.1e-47 162.3 7.4 2.6 2 2 1 3 3 3 1 Sodium Bile acid symporter family Zn_clus PF00172.18 CRG86534.1 - 1e-06 28.7 8.2 1.9e-06 27.9 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG86534.1 - 1.7e-06 27.3 0.0 4.6e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 CRG86535.1 - 1.1e-15 57.4 0.6 2.2e-15 56.4 0.6 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG86536.1 - 4.4e-35 121.2 33.6 4.4e-35 121.2 33.6 2.2 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF2798 PF11391.8 CRG86536.1 - 0.023 14.7 1.0 0.023 14.7 1.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) Pox_A14 PF05767.12 CRG86536.1 - 5.6 7.2 8.6 3.1 8.0 0.0 3.7 3 1 0 4 4 4 0 Poxvirus virion envelope protein A14 Arylsulfotran_2 PF14269.6 CRG86537.1 - 7.2e-43 147.1 0.6 1.1e-42 146.5 0.6 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CRG86537.1 - 5.7e-10 38.6 0.2 2.5e-09 36.6 0.2 1.9 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.6 CRG86537.1 - 0.019 14.5 0.5 0.9 9.1 0.0 3.3 2 1 1 3 3 3 0 PQQ-like domain MAPEG PF01124.18 CRG86538.1 - 4.2e-12 46.1 1.7 8e-12 45.2 1.6 1.5 1 1 0 1 1 1 1 MAPEG family adh_short PF00106.25 CRG86539.1 - 1.1e-36 126.1 0.7 2.7e-36 124.9 0.7 1.6 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86539.1 - 5.2e-35 121.1 3.0 6.8e-29 101.1 1.4 2.9 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86539.1 - 2e-10 40.9 0.6 3.9e-09 36.7 0.6 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG86539.1 - 0.0043 16.5 0.8 0.02 14.3 0.8 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 CRG86540.1 - 6.1e-25 87.7 0.2 8.5e-25 87.3 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86540.1 - 3.8e-07 30.1 10.1 1e-06 28.7 10.1 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_2 PF04909.14 CRG86541.1 - 1.7e-26 93.7 0.3 2.3e-26 93.3 0.3 1.1 1 0 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.16 CRG86542.1 - 4.5e-27 94.9 17.6 6.4e-27 94.4 17.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily 2-Hacid_dh_C PF02826.19 CRG86543.1 - 3.2e-54 183.0 0.1 4.8e-54 182.4 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG86543.1 - 2.5e-27 95.2 0.1 2.8e-27 95.0 0.1 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG86543.1 - 0.00028 21.1 0.3 0.00085 19.5 0.1 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CRG86543.1 - 0.0019 18.3 0.1 0.0034 17.5 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain F420_oxidored PF03807.17 CRG86543.1 - 0.041 14.5 1.5 0.081 13.5 0.4 2.2 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Gp_dh_N PF00044.24 CRG86543.1 - 0.049 14.0 0.0 0.37 11.2 0.0 2.2 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Glyco_transf_8 PF01501.20 CRG86544.1 - 0.0014 18.2 0.1 0.0058 16.2 0.1 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 CRG86544.1 - 0.014 14.7 0.0 0.021 14.2 0.0 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative Nucleotid_trans PF03407.16 CRG86544.1 - 0.14 12.1 0.0 0.31 11.0 0.0 1.5 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Aa_trans PF01490.18 CRG86545.1 - 3.6e-33 114.9 23.3 5.6e-33 114.2 23.3 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein FAD_binding_3 PF01494.19 CRG86547.1 - 3.1e-21 76.0 0.0 3.8e-21 75.7 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG86547.1 - 5.1e-06 25.9 0.0 0.021 14.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG86547.1 - 6.2e-05 22.7 0.0 0.011 15.4 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG86547.1 - 0.001 19.3 0.0 0.0025 18.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG86547.1 - 0.003 18.1 0.0 0.067 13.8 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 CRG86547.1 - 0.0045 15.6 0.0 0.0082 14.7 0.0 1.3 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) NAD_binding_9 PF13454.6 CRG86547.1 - 0.0071 16.4 0.0 5 7.1 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG86547.1 - 0.058 12.6 0.0 9 5.4 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG86547.1 - 0.095 11.9 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family LIP PF03583.14 CRG86548.1 - 1.8e-08 34.1 0.1 0.0039 16.6 0.0 2.2 2 0 0 2 2 2 2 Secretory lipase Hydrolase_4 PF12146.8 CRG86548.1 - 1e-07 31.5 0.0 6.4e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG86548.1 - 1.3e-07 32.5 0.9 2.2e-07 31.7 0.9 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CRG86548.1 - 0.0011 18.6 0.0 0.25 10.8 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CRG86548.1 - 0.0037 17.0 0.1 3.1 7.4 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 CRG86548.1 - 0.063 12.9 0.0 4.5 6.9 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Peroxidase_2 PF01328.17 CRG86549.1 - 1.4e-52 178.9 0.0 1.8e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 ADH_zinc_N PF00107.26 CRG86550.1 - 1.8e-06 28.0 0.0 9.6e-06 25.6 0.0 2.1 1 1 1 2 2 2 1 Zinc-binding dehydrogenase Tannase PF07519.11 CRG86551.1 - 1.9e-146 488.7 3.8 2.2e-146 488.4 3.8 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Glyco_hydro_3_C PF01915.22 CRG86552.1 - 8.2e-47 159.8 0.0 1.5e-46 159.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG86552.1 - 7.2e-41 140.6 0.0 1.2e-40 139.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG86552.1 - 2.4e-21 75.6 0.0 5.1e-21 74.6 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain TSCPD PF12637.7 CRG86552.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 TSCPD domain SBP_bac_11 PF13531.6 CRG86553.1 - 0.11 12.3 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein PBP PF01161.20 CRG86554.1 - 1.3e-16 61.1 0.2 1.7e-16 60.7 0.2 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein AA_permease_2 PF13520.6 CRG86555.1 - 1.4e-57 195.4 51.7 1.8e-57 195.1 51.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG86555.1 - 1.8e-16 59.8 44.3 3.6e-16 58.8 44.3 1.4 1 1 0 1 1 1 1 Amino acid permease adh_short PF00106.25 CRG86556.1 - 0.00012 21.6 0.0 0.00032 20.2 0.0 1.7 2 0 0 2 2 2 1 short chain dehydrogenase Glyco_hydro_72 PF03198.14 CRG86557.1 - 1.4e-116 389.1 3.1 2.2e-116 388.6 3.1 1.2 1 0 0 1 1 1 1 Glucanosyltransferase Mre11_DNA_bind PF04152.14 CRG86557.1 - 2.9e-57 193.7 1.1 7.5e-57 192.3 1.1 1.8 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 CRG86557.1 - 1.6e-13 51.6 2.4 3.1e-13 50.7 2.4 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG86557.1 - 0.0035 17.5 0.3 0.027 14.6 0.3 2.4 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DinB_2 PF12867.7 CRG86557.1 - 0.024 15.2 0.1 5.3 7.6 0.0 2.7 2 0 0 2 2 2 0 DinB superfamily AP3D1 PF06375.11 CRG86557.1 - 0.12 12.6 3.0 0.54 10.5 3.0 2.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 CHIP_TPR_N PF18391.1 CRG86557.1 - 0.51 11.1 6.9 11 6.8 1.6 2.8 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain DUF3439 PF11921.8 CRG86557.1 - 1.4 8.9 3.4 5.6 7.0 3.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CTP_synth_N PF06418.14 CRG86560.1 - 2e-118 394.5 0.0 2.6e-118 394.1 0.0 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CRG86560.1 - 2.8e-51 174.0 0.0 4.3e-51 173.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CRG86560.1 - 0.0011 18.8 0.1 0.0064 16.3 0.1 2.2 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 CRG86560.1 - 0.01 15.9 0.0 0.062 13.4 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Aldedh PF00171.22 CRG86561.1 - 5.2e-184 612.1 0.1 5.9e-184 611.9 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sugar_tr PF00083.24 CRG86562.1 - 9.8e-17 60.9 2.1 1.2e-16 60.7 2.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86562.1 - 0.0014 17.6 0.5 0.0017 17.3 0.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Metallophos PF00149.28 CRG86563.1 - 1.1e-34 120.8 0.0 3.1e-30 106.2 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 CRG86563.1 - 0.099 12.3 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Smg4_UPF3 PF03467.15 CRG86564.1 - 6.3e-41 140.3 0.0 6.3e-41 140.3 0.0 3.3 3 1 0 3 3 3 1 Smg-4/UPF3 family RRM_1 PF00076.22 CRG86564.1 - 1.9e-08 34.0 0.5 7.2e-07 28.9 0.1 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4440 PF14534.6 CRG86564.1 - 0.11 12.9 0.2 0.38 11.2 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) CHZ PF09649.10 CRG86564.1 - 0.5 9.9 2.8 1.5 8.3 2.8 1.9 1 0 0 1 1 1 0 Histone chaperone domain CHZ Arylsulfotran_2 PF14269.6 CRG86565.1 - 2.3e-63 214.4 1.3 3.1e-63 213.9 1.3 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ PF01011.21 CRG86565.1 - 0.18 11.8 2.2 13 5.9 0.1 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat MFS_1 PF07690.16 CRG86566.1 - 1.2e-38 133.0 66.9 3.4e-28 98.6 36.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG86567.1 - 6.9e-11 41.7 0.0 1e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG86568.1 - 9.8e-38 129.6 2.1 2.2e-37 128.4 2.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase MFS_1 PF07690.16 CRG86568.1 - 3.4e-36 124.9 26.9 3.4e-36 124.9 26.9 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily adh_short_C2 PF13561.6 CRG86568.1 - 5.8e-35 120.9 0.5 2.3e-34 119.0 0.5 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86568.1 - 7.1e-09 35.8 0.7 1.4e-08 34.9 0.7 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG86568.1 - 0.021 14.3 0.2 0.04 13.4 0.2 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CRG86568.1 - 0.044 13.7 1.3 0.069 13.0 1.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sulf_coat_C PF12193.8 CRG86568.1 - 0.094 12.8 0.8 0.32 11.1 0.2 2.1 2 0 0 2 2 2 0 Sulfolobus virus coat protein C terminal Enoyl_reductase PF12241.8 CRG86568.1 - 0.14 11.5 0.0 0.27 10.5 0.0 1.4 1 0 0 1 1 1 0 Trans-2-enoyl-CoA reductase catalytic region PhyH PF05721.13 CRG86569.1 - 2.1e-13 51.0 0.0 2.9e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 CRG86569.1 - 0.086 13.3 0.0 0.2 12.1 0.0 1.6 1 1 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase 2-Hacid_dh_C PF02826.19 CRG86570.1 - 6.7e-42 142.8 0.1 1.1e-41 142.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG86570.1 - 9.6e-11 41.5 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 CRG86570.1 - 0.00073 20.1 0.1 0.0013 19.2 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CRG86570.1 - 0.0009 19.4 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 CRG86570.1 - 0.0024 18.0 0.0 0.0035 17.4 0.0 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain IlvN PF07991.12 CRG86570.1 - 0.015 14.9 0.0 0.044 13.4 0.0 1.7 1 1 1 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 CRG86570.1 - 0.12 11.7 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Wyosine_form PF08608.12 CRG86571.1 - 2.3e-23 82.3 0.2 6e-23 81.0 0.0 1.8 2 0 0 2 2 2 1 Wyosine base formation Radical_SAM PF04055.21 CRG86571.1 - 3.2e-22 79.7 0.1 1.7e-21 77.3 0.1 2.3 2 1 0 2 2 2 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 CRG86571.1 - 5.1e-08 33.2 0.6 4.2e-07 30.3 0.0 2.6 2 1 0 2 2 2 1 Flavodoxin Peptidase_M19 PF01244.21 CRG86572.1 - 1e-100 337.0 0.0 1.2e-100 336.8 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) DJ-1_PfpI PF01965.24 CRG86573.1 - 3.3e-08 33.5 0.0 1.1e-07 31.8 0.0 1.8 1 1 0 1 1 1 1 DJ-1/PfpI family Fungal_trans PF04082.18 CRG86574.1 - 1.9e-21 76.3 0.1 3.4e-21 75.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86574.1 - 1.6e-07 31.3 10.2 2.6e-07 30.7 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NUDIX PF00293.28 CRG86575.1 - 5.7e-12 45.8 0.1 8.8e-12 45.2 0.1 1.3 1 0 0 1 1 1 1 NUDIX domain DUF3405 PF11885.8 CRG86575.1 - 0.073 11.7 1.6 3.9 6.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) Ribosomal_S13_N PF08069.12 CRG86575.1 - 0.13 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain HATPase_c PF02518.26 CRG86576.1 - 3.5e-28 98.3 0.0 8.4e-28 97.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG86576.1 - 8e-23 80.8 1.0 1.7e-22 79.7 1.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain PAS PF00989.25 CRG86576.1 - 1.4e-21 76.6 0.0 1.5e-11 44.3 0.0 2.6 2 0 0 2 2 2 2 PAS fold HisKA PF00512.25 CRG86576.1 - 4.3e-18 65.1 0.1 9.2e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_4 PF08448.10 CRG86576.1 - 2.5e-17 63.1 0.0 8e-08 32.5 0.0 2.5 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 CRG86576.1 - 5.7e-16 58.7 0.0 6.2e-10 39.3 0.0 2.7 2 0 0 2 2 2 2 PAS domain PAS_8 PF13188.7 CRG86576.1 - 5.9e-05 23.0 0.0 0.61 10.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain Ferritin PF00210.24 CRG86577.1 - 1.8e-14 53.9 0.0 2.7e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain AP_endonuc_2 PF01261.24 CRG86577.1 - 0.075 12.5 0.0 0.13 11.7 0.0 1.5 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel BPD_transp_1 PF00528.22 CRG86578.1 - 0.00061 19.6 6.4 0.34 10.6 0.6 2.7 1 1 1 2 2 2 2 Binding-protein-dependent transport system inner membrane component Sigma_reg_N PF13800.6 CRG86578.1 - 0.003 17.8 0.5 0.003 17.8 0.5 2.4 3 0 0 3 3 2 1 Sigma factor regulator N-terminal YqfD PF06898.11 CRG86578.1 - 0.0035 16.2 3.5 0.0043 16.0 0.9 1.9 2 0 0 2 2 2 1 Putative stage IV sporulation protein YqfD DUF423 PF04241.15 CRG86578.1 - 0.0052 16.9 0.5 0.014 15.6 0.5 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF423) NrsF PF06532.11 CRG86578.1 - 0.008 15.9 0.4 0.008 15.9 0.4 2.7 3 1 0 3 3 3 1 Negative regulator of sigma F Ilm1 PF10311.9 CRG86578.1 - 0.027 14.1 0.7 0.088 12.4 0.7 1.9 1 1 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 TMEM154 PF15102.6 CRG86578.1 - 0.76 9.7 2.2 0.71 9.8 0.2 1.8 2 0 0 2 2 2 0 TMEM154 protein family Ac76 PF05814.11 CRG86578.1 - 0.76 9.8 10.3 0.076 13.0 5.0 1.9 2 0 0 2 2 2 0 Orf76 (Ac76) MerC PF03203.14 CRG86578.1 - 1.4 9.3 8.0 3 8.3 3.9 2.7 1 1 1 2 2 2 0 MerC mercury resistance protein DUF2085 PF09858.9 CRG86578.1 - 3.3 8.3 7.9 2 8.9 1.4 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2085) DUF2393 PF09624.10 CRG86578.1 - 3.4 7.7 7.1 0.53 10.3 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) DUF4199 PF13858.6 CRG86578.1 - 4.7 7.6 10.7 0.19 12.1 1.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) PGG PF13962.6 CRG86578.1 - 4.9 7.0 9.4 0.73 9.7 3.3 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF3169 PF11368.8 CRG86578.1 - 5.7 6.4 8.7 1.4 8.4 5.5 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) SUR7 PF06687.12 CRG86578.1 - 5.7 6.5 9.5 22 4.6 9.6 1.9 1 1 0 1 1 1 0 SUR7/PalI family 7tm_3 PF00003.22 CRG86578.1 - 6.9 6.3 13.1 3.2 7.4 9.6 2.2 2 1 0 2 2 2 0 7 transmembrane sweet-taste receptor of 3 GCPR DHHC PF01529.20 CRG86578.1 - 6.9 6.8 10.4 5.7 7.1 1.1 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF4131 PF13567.6 CRG86578.1 - 7.4 6.2 9.7 0.35 10.5 0.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) MAS20 PF02064.15 CRG86579.1 - 2.5e-45 153.7 0.5 2.9e-45 153.5 0.5 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor LapA_dom PF06305.11 CRG86579.1 - 0.077 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4199 PF13858.6 CRG86579.1 - 0.23 11.9 0.0 0.3 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Exo84_C PF16528.5 CRG86580.1 - 4.3e-70 235.7 0.3 4.3e-70 235.7 0.3 2.0 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 CRG86580.1 - 2e-18 66.3 1.5 2e-18 66.3 1.5 2.0 2 0 0 2 2 2 1 Vps51/Vps67 Med30 PF11315.8 CRG86580.1 - 0.038 14.2 3.1 0.05 13.8 1.9 1.8 2 0 0 2 2 2 0 Mediator complex subunit 30 BST2 PF16716.5 CRG86580.1 - 0.039 14.5 4.0 6.7 7.4 2.4 2.9 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Exonuc_VII_L PF02601.15 CRG86580.1 - 0.14 11.7 4.2 0.74 9.3 0.7 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit HIP1_clath_bdg PF16515.5 CRG86580.1 - 1.8 9.2 6.7 1.5 9.5 2.9 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ABC_tran PF00005.27 CRG86581.1 - 2.4e-22 79.9 0.0 1.1e-10 42.1 0.0 3.4 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 CRG86581.1 - 4e-05 23.6 6.0 0.065 13.0 1.0 3.2 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CRG86581.1 - 0.00092 19.4 0.0 0.12 12.6 0.0 2.5 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CRG86581.1 - 0.014 15.2 0.2 0.041 13.6 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Ploopntkinase1 PF18748.1 CRG86581.1 - 0.059 12.9 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 AAA_23 PF13476.6 CRG86581.1 - 0.062 13.8 0.6 0.11 12.9 0.6 1.4 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 CRG86581.1 - 0.075 10.5 0.1 0.1 10.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_16 PF13191.6 CRG86581.1 - 0.19 12.1 0.6 4.5 7.6 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain AMP-binding PF00501.28 CRG86582.1 - 2.5e-82 276.7 0.0 3e-82 276.5 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG86582.1 - 1.4e-14 54.8 0.2 3.6e-14 53.5 0.2 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ZapB PF06005.12 CRG86583.1 - 0.0015 18.9 1.2 0.0015 18.9 1.2 2.6 2 1 0 2 2 2 1 Cell division protein ZapB SlyX PF04102.12 CRG86583.1 - 0.055 14.1 6.6 3.5 8.3 1.3 3.1 2 1 1 3 3 3 0 SlyX GIT_CC PF16559.5 CRG86583.1 - 0.058 13.3 3.5 0.22 11.4 2.3 2.6 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DASH_Dam1 PF08653.10 CRG86583.1 - 0.15 11.9 3.3 0.16 11.8 1.0 2.2 2 1 0 2 2 2 0 DASH complex subunit Dam1 SPACA9 PF15120.6 CRG86583.1 - 0.16 11.7 3.0 0.51 10.1 0.7 2.4 1 1 0 2 2 2 0 Sperm acrosome-associated protein 9 DUF1664 PF07889.12 CRG86583.1 - 0.85 9.7 5.6 5.6 7.0 0.3 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 CRG86583.1 - 3.2 7.9 8.1 1.3 9.2 0.7 3.2 2 2 1 3 3 3 0 bZIP transcription factor MFS_1 PF07690.16 CRG86584.1 - 3e-32 111.9 30.7 4.7e-32 111.3 30.7 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily CPSase_L_D2 PF02786.17 CRG86585.1 - 2.7e-113 376.6 0.1 1.9e-83 279.2 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 CRG86585.1 - 2.9e-47 160.9 0.0 7.2e-47 159.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 CRG86585.1 - 5.1e-47 158.9 0.0 1e-46 157.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 CRG86585.1 - 1.8e-45 154.6 0.0 4.9e-45 153.2 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 CRG86585.1 - 3.9e-39 133.8 0.0 9.7e-39 132.5 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 CRG86585.1 - 9.2e-31 107.0 0.0 3.3e-30 105.2 0.0 2.0 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 CRG86585.1 - 1.6e-22 79.5 0.0 7.6e-22 77.3 0.0 2.3 1 0 0 1 1 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 CRG86585.1 - 3.8e-17 62.5 0.2 1.6e-08 34.4 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CRG86585.1 - 3.6e-16 59.2 0.0 9.9e-08 31.7 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CRG86585.1 - 1.9e-09 37.3 0.0 0.00021 21.1 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 CRG86585.1 - 1.3e-05 25.1 0.4 0.0013 18.6 0.4 2.6 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 CRG86585.1 - 2.9e-05 23.9 0.1 0.022 14.6 0.0 4.4 4 0 0 4 4 4 1 DJ-1/PfpI family ATP-grasp_3 PF02655.14 CRG86585.1 - 3.8e-05 23.8 0.3 0.074 13.1 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp domain RimK PF08443.11 CRG86585.1 - 0.0024 17.5 0.0 1.6 8.3 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.19 CRG86585.1 - 0.01 15.6 0.2 4 7.2 0.0 2.9 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Ish1 PF10281.9 CRG86585.1 - 0.12 12.8 0.0 15 6.0 0.0 2.8 2 0 0 2 2 2 0 Putative stress-responsive nuclear envelope protein Ion_trans PF00520.31 CRG86586.1 - 1e-07 31.5 23.8 1.5e-07 30.9 23.8 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3638 PF12340.8 CRG86587.1 - 2.7e-97 324.5 0.3 2.7e-97 324.5 0.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) Ank_2 PF12796.7 CRG86587.1 - 3.5e-31 107.6 4.8 4.1e-06 27.3 0.0 11.9 10 1 1 12 12 12 6 Ankyrin repeats (3 copies) DUF3645 PF12359.8 CRG86587.1 - 1.3e-14 53.3 0.3 2.5e-14 52.3 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) Ank_4 PF13637.6 CRG86587.1 - 1.5e-12 47.7 6.5 0.54 10.9 0.0 11.4 15 0 0 15 15 15 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG86587.1 - 2.6e-10 39.6 1.3 30 5.6 0.0 11.9 14 1 0 14 14 14 0 Ankyrin repeat Ank PF00023.30 CRG86587.1 - 3.1e-09 36.9 9.1 21 5.8 0.0 11.2 10 2 1 11 11 11 1 Ankyrin repeat Ank_5 PF13857.6 CRG86587.1 - 5.8e-06 26.5 3.1 2e+02 2.5 0.0 9.6 11 0 0 11 11 11 0 Ankyrin repeats (many copies) SpoU_sub_bind PF08032.12 CRG86587.1 - 0.065 13.5 0.0 59 4.0 0.0 4.4 4 0 0 4 4 4 0 RNA 2'-O ribose methyltransferase substrate binding GFO_IDH_MocA PF01408.22 CRG86588.1 - 1.9e-15 57.7 0.0 2.9e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Fungal_trans PF04082.18 CRG86591.1 - 2.6e-14 52.9 0.0 4.3e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86591.1 - 2.7e-10 40.2 4.5 4.1e-10 39.6 4.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_MalT PF17874.1 CRG86591.1 - 0.084 12.2 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 MalT-like TPR region DUF4357 PF14267.6 CRG86591.1 - 0.12 12.3 0.2 4 7.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) Ost4 PF10215.9 CRG86592.1 - 1.3e-18 66.5 1.9 1.9e-18 66.0 1.9 1.2 1 0 0 1 1 1 1 Oligosaccaryltransferase Synaptobrevin PF00957.21 CRG86593.1 - 1.6e-29 101.5 0.0 3.8e-29 100.3 0.0 1.6 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CRG86593.1 - 3.8e-27 94.1 0.1 9.1e-27 92.9 0.1 1.7 1 0 0 1 1 1 1 Regulated-SNARE-like domain COX6C PF02937.15 CRG86593.1 - 0.0089 16.1 0.1 0.024 14.7 0.1 1.7 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc DUF1980 PF09323.10 CRG86593.1 - 0.11 12.3 0.1 0.52 10.2 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) FOXP-CC PF16159.5 CRG86593.1 - 1.5 9.5 5.5 7.1 7.3 1.4 2.6 1 1 1 2 2 2 0 FOXP coiled-coil domain RabGAP-TBC PF00566.18 CRG86594.1 - 7.4e-44 150.0 0.0 7.2e-42 143.5 0.0 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain adh_short_C2 PF13561.6 CRG86595.1 - 2.5e-55 187.6 0.9 3e-55 187.3 0.9 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86595.1 - 7.1e-48 162.6 0.5 8.9e-48 162.3 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86595.1 - 7e-10 39.1 0.2 2.2e-09 37.5 0.2 1.7 1 1 0 1 1 1 1 KR domain DENN PF02141.21 CRG86596.1 - 2.2e-39 135.3 0.7 3.9e-39 134.5 0.1 1.8 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 CRG86596.1 - 4.2e-06 27.4 0.1 1.8e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 uDENN domain Elongin_A PF06881.11 CRG86596.1 - 0.06 13.9 8.3 0.021 15.3 3.9 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A CENP-F_leu_zip PF10473.9 CRG86596.1 - 7.5 6.6 21.8 0.09 12.8 5.4 3.2 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF632 PF04782.12 CRG86597.1 - 0.16 11.3 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF632) Pkinase PF00069.25 CRG86598.1 - 5e-24 85.1 0.0 8.3e-24 84.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 CRG86598.1 - 1.8e-11 43.2 6.1 0.024 14.9 0.2 6.7 6 0 0 6 6 6 3 HEAT repeat WD40 PF00400.32 CRG86598.1 - 1.2e-08 35.5 12.2 1.4e-05 25.8 0.1 5.6 5 0 0 5 5 5 2 WD domain, G-beta repeat Pkinase_Tyr PF07714.17 CRG86598.1 - 1.1e-05 24.9 0.0 1.7e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 CRG86598.1 - 0.00037 20.8 0.0 7.2 7.1 0.0 4.2 2 2 2 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 CRG86598.1 - 0.0013 19.2 0.7 0.14 12.7 0.2 3.6 4 0 0 4 4 4 1 HEAT-like repeat Ge1_WD40 PF16529.5 CRG86598.1 - 0.011 14.7 0.0 0.034 13.1 0.0 1.7 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RTP1_C1 PF10363.9 CRG86598.1 - 0.032 14.4 0.1 5.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Tti2 PF10521.9 CRG86598.1 - 0.039 13.5 0.0 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 Tti2 family Adaptin_N PF01602.20 CRG86598.1 - 0.13 10.8 0.8 3.1 6.3 0.5 2.3 2 0 0 2 2 2 0 Adaptin N terminal region Cnd1 PF12717.7 CRG86598.1 - 0.2 11.7 0.0 37 4.3 0.0 3.1 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 MiAMP1 PF09117.10 CRG86601.1 - 0.071 13.4 4.3 0.22 11.7 0.1 2.2 2 0 0 2 2 2 0 MiAMP1 NUDIX PF00293.28 CRG86602.1 - 3e-19 69.3 0.0 4e-19 68.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain DEAD PF00270.29 CRG86603.1 - 3.3e-47 160.5 0.0 1.3e-46 158.6 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG86603.1 - 7.5e-23 81.0 0.0 3.3e-21 75.7 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 CRG86603.1 - 8.6e-19 67.6 0.5 8.6e-19 67.6 0.5 2.5 2 0 0 2 2 2 1 DBP10CT (NUC160) domain RPA_C PF08784.11 CRG86604.1 - 4e-20 72.4 0.0 1.4e-19 70.7 0.0 1.9 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 CRG86604.1 - 1.9e-06 27.7 0.0 3.1e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain MarR_2 PF12802.7 CRG86604.1 - 0.12 12.2 0.0 0.31 11.0 0.0 1.6 2 0 0 2 2 2 0 MarR family MatE PF01554.18 CRG86605.1 - 2e-58 196.6 31.1 1.4e-35 122.3 11.3 2.4 2 0 0 2 2 2 2 MatE Zn_clus PF00172.18 CRG86606.1 - 0.00017 21.7 10.6 0.00025 21.1 10.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AT_hook PF02178.19 CRG86606.1 - 9.5 6.5 8.5 0.7 10.0 0.3 3.6 3 0 0 3 3 3 0 AT hook motif AA_permease PF00324.21 CRG86607.1 - 1.9e-126 422.5 43.0 2.3e-126 422.2 43.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG86607.1 - 5.7e-38 130.9 51.9 7e-38 130.6 51.9 1.1 1 0 0 1 1 1 1 Amino acid permease APH PF01636.23 CRG86607.1 - 1.4e-05 25.1 0.0 2.3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG86607.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase DEAD PF00270.29 CRG86608.1 - 4.4e-48 163.4 0.0 1.2e-47 161.9 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG86608.1 - 4.4e-25 88.2 0.0 3.8e-24 85.2 0.0 2.7 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CRG86608.1 - 7.7e-21 74.1 0.0 2.7e-20 72.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CRG86608.1 - 3.5e-07 30.4 0.0 1.4e-06 28.5 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DnaJ PF00226.31 CRG86609.1 - 4.8e-14 52.2 3.8 9.3e-14 51.3 0.5 2.9 3 0 0 3 3 3 1 DnaJ domain FKBP26_C PF18046.1 CRG86609.1 - 0.0036 17.4 0.0 0.02 15.0 0.0 2.0 2 0 0 2 2 2 1 FKBP26_C-terminal RRM_1 PF00076.22 CRG86610.1 - 2.4e-24 84.9 0.1 1e-12 47.7 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG86610.1 - 0.068 13.2 0.1 0.25 11.3 0.0 1.9 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif FAD_binding_1 PF00667.20 CRG86611.1 - 1.9e-65 220.6 0.0 2.7e-65 220.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CRG86611.1 - 1.1e-32 113.2 1.3 2e-32 112.4 1.3 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CRG86611.1 - 2.7e-21 76.2 0.0 2.2e-20 73.3 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain MOR2-PAG1_N PF14222.6 CRG86612.1 - 3.3e-208 693.1 0.0 5.8e-208 692.3 0.0 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 CRG86612.1 - 6.1e-89 298.2 0.1 6.1e-89 298.2 0.1 3.0 4 0 0 4 4 4 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 CRG86612.1 - 5.7e-33 113.7 12.0 1.1e-13 49.8 0.3 3.9 2 1 1 3 3 3 3 Cell morphogenesis central region NAD_binding_2 PF03446.15 CRG86613.1 - 8.7e-34 117.0 0.0 1.2e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG86613.1 - 4.4e-29 101.2 0.0 6.7e-29 100.6 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CRG86613.1 - 0.00013 22.5 0.0 0.00026 21.5 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CRG86613.1 - 0.068 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA PF01408.22 CRG86613.1 - 0.088 13.6 0.0 0.14 13.0 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold MMS1_N PF10433.9 CRG86614.1 - 2e-130 435.7 0.0 3e-130 435.1 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CRG86614.1 - 5.7e-72 242.8 0.0 1.4e-69 234.9 0.0 3.2 3 0 0 3 3 3 1 CPSF A subunit region FMO-like PF00743.19 CRG86615.1 - 1.4e-11 43.6 0.1 5.4e-11 41.6 0.0 2.0 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG86615.1 - 5.6e-11 42.2 0.0 1.5e-06 27.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG86615.1 - 2.1e-10 40.4 0.0 4.2e-08 32.8 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG86615.1 - 1.2e-08 34.5 0.3 7.9e-06 25.2 0.1 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CRG86615.1 - 7.8e-07 29.2 0.0 2.4e-06 27.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG86615.1 - 8.2e-06 25.6 0.2 0.29 10.7 0.0 3.3 2 1 1 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 CRG86615.1 - 0.0018 17.5 0.0 0.02 14.1 0.0 2.2 2 0 0 2 2 2 1 Thi4 family Shikimate_DH PF01488.20 CRG86615.1 - 0.0034 17.5 0.0 0.17 12.0 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.12 CRG86615.1 - 0.0043 16.1 0.0 0.053 12.6 0.0 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 CRG86615.1 - 0.03 14.3 0.2 4.1 7.4 0.0 3.0 3 1 0 3 3 3 0 FAD-NAD(P)-binding GIDA PF01134.22 CRG86615.1 - 0.17 10.9 0.0 6.6 5.7 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Mqo PF06039.15 CRG86615.1 - 0.22 10.0 0.0 2.3 6.7 0.0 2.2 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Fungal_trans_2 PF11951.8 CRG86616.1 - 2.8e-07 29.7 2.8 2.8e-06 26.4 2.8 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86616.1 - 0.00065 19.8 9.4 0.0013 18.8 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rax2 PF12768.7 CRG86617.1 - 2e-73 246.4 2.4 4.4e-72 242.0 0.0 3.4 4 0 0 4 4 4 1 Cortical protein marker for cell polarity Kelch_6 PF13964.6 CRG86617.1 - 0.0041 17.3 4.8 1.7 9.1 0.1 5.8 5 0 0 5 5 5 1 Kelch motif Phage_tail_L PF05100.12 CRG86617.1 - 0.091 12.1 0.0 0.24 10.7 0.0 1.7 1 0 0 1 1 1 0 Phage minor tail protein L FAD_binding_3 PF01494.19 CRG86619.1 - 1.1e-20 74.3 0.0 3.6e-11 42.9 0.0 2.9 2 1 0 2 2 2 2 FAD binding domain Pyr_redox PF00070.27 CRG86619.1 - 0.0003 21.3 0.1 0.0015 19.0 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG86619.1 - 0.00035 20.8 0.0 0.00066 19.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CRG86619.1 - 0.0059 15.9 0.1 0.01 15.1 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG86619.1 - 0.021 13.5 0.0 0.032 12.9 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_2 PF07992.14 CRG86619.1 - 0.037 13.3 0.0 0.14 11.4 0.0 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG86619.1 - 0.17 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 CRG86619.1 - 0.2 11.0 0.0 0.37 10.0 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Cupin_2 PF07883.11 CRG86620.1 - 4.2e-16 58.4 0.1 1.4e-07 31.1 0.2 2.3 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 CRG86620.1 - 2.4e-09 37.2 0.1 0.0003 20.7 0.0 2.4 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 CRG86620.1 - 5.4e-08 32.4 0.2 0.0016 18.1 0.1 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF861) ARD PF03079.14 CRG86620.1 - 4e-06 27.1 0.1 0.029 14.5 0.0 2.3 2 0 0 2 2 2 2 ARD/ARD' family EutQ PF06249.12 CRG86620.1 - 0.034 13.9 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutQ Fungal_trans PF04082.18 CRG86621.1 - 3e-10 39.6 0.4 5.6e-10 38.7 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86621.1 - 6.4e-09 35.8 10.2 6.4e-09 35.8 10.2 3.0 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 CRG86621.1 - 0.0011 19.6 19.7 0.0013 19.4 3.1 4.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG86621.1 - 0.0019 18.6 4.7 0.0019 18.6 4.7 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 CRG86621.1 - 0.0026 17.7 3.1 0.0026 17.7 3.1 3.2 3 0 0 3 3 3 1 C2H2-type zinc finger DUF678 PF05077.12 CRG86621.1 - 8 6.7 7.7 3.1 8.0 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF678) SSrecog PF03531.14 CRG86622.1 - 5.2e-32 109.6 0.3 1.3e-30 105.1 0.0 3.2 4 0 0 4 4 4 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 CRG86622.1 - 1.3e-26 92.8 0.0 1.9e-25 89.1 0.0 2.5 2 0 0 2 2 2 1 Histone chaperone Rttp106-like POB3_N PF17292.2 CRG86622.1 - 7.2e-21 74.4 0.1 4.5e-19 68.7 0.0 3.0 3 0 0 3 3 3 1 POB3-like N-terminal PH domain Methyltransf_11 PF08241.12 CRG86623.1 - 0.06 14.0 0.0 0.16 12.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CRG86623.1 - 0.11 13.3 0.0 0.56 10.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain SAP PF02037.27 CRG86624.1 - 3.5e-13 49.0 0.6 3.5e-13 49.0 0.6 2.0 2 0 0 2 2 2 1 SAP domain Tho1_MOS11_C PF18592.1 CRG86624.1 - 2.1e-06 27.4 0.1 2.1e-06 27.4 0.1 2.3 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain CCT_2 PF09425.10 CRG86624.1 - 9.4 6.2 7.3 3.5 7.6 1.0 2.5 2 0 0 2 2 2 0 Divergent CCT motif DUF3455 PF11937.8 CRG86625.1 - 5e-40 137.5 0.2 6.2e-40 137.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) zf-H2C2_2 PF13465.6 CRG86626.1 - 2.2e-10 40.5 14.7 2.3e-05 24.6 0.4 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 CRG86626.1 - 8.1e-10 38.6 11.5 2.2e-05 24.6 4.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG86626.1 - 1e-06 29.0 10.7 0.0013 19.4 3.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 CRG86626.1 - 5.8e-06 26.5 1.3 1.8e-05 25.0 1.3 1.9 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CRG86626.1 - 0.00012 22.0 2.4 0.00012 22.0 2.4 2.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG86626.1 - 0.00073 19.8 5.1 0.00074 19.7 1.8 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CRG86626.1 - 0.089 13.1 2.7 0.079 13.3 1.2 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2HC_2 PF13913.6 CRG86626.1 - 0.11 12.4 4.2 2.9 7.9 0.4 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Actin_micro PF17003.5 CRG86626.1 - 0.29 10.2 0.3 0.4 9.8 0.3 1.1 1 0 0 1 1 1 0 Putative actin-like family zf-C2H2_11 PF16622.5 CRG86626.1 - 0.43 10.4 7.2 6.7 6.6 0.8 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type SF3b1 PF08920.10 CRG86627.1 - 2.6e-30 105.3 12.6 6.7e-30 104.0 5.4 3.4 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 CRG86627.1 - 1.4e-11 44.6 9.8 0.21 12.0 0.1 8.7 4 2 5 10 10 10 4 HEAT repeats HEAT_EZ PF13513.6 CRG86627.1 - 2.6e-10 40.6 1.7 0.044 14.3 0.0 6.6 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 CRG86627.1 - 7.4e-10 38.2 9.6 0.088 13.1 0.3 9.0 9 0 0 9 9 9 3 HEAT repeat Cnd1 PF12717.7 CRG86627.1 - 1.9e-08 34.5 1.0 0.083 12.9 0.0 6.3 5 2 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CRG86627.1 - 3.1e-05 22.7 0.8 0.073 11.6 0.1 3.5 3 1 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 CRG86627.1 - 0.00015 22.3 0.7 10 6.8 0.0 5.3 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 CRG86627.1 - 0.0005 19.8 0.3 1.2 8.8 0.0 4.1 5 0 0 5 5 5 2 NUC173 domain UNC45-central PF11701.8 CRG86627.1 - 0.00065 19.7 0.0 0.0028 17.6 0.0 2.0 2 0 0 2 2 2 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 CRG86627.1 - 0.003 17.2 0.2 0.93 9.0 0.0 3.4 3 0 0 3 3 3 1 CLASP N terminal DUF3385 PF11865.8 CRG86627.1 - 0.019 14.9 5.0 0.94 9.4 0.1 5.0 4 1 1 6 6 6 0 Domain of unknown function (DUF3385) EF-1_beta_acid PF10587.9 CRG86627.1 - 0.24 11.9 1.5 0.93 10.0 1.5 2.2 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Casein PF00363.18 CRG86628.1 - 0.07 13.5 0.3 0.14 12.5 0.3 1.8 1 1 0 1 1 1 0 Casein DUF3842 PF12953.7 CRG86628.1 - 0.23 11.8 0.1 0.3 11.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) Aldo_ket_red PF00248.21 CRG86629.1 - 1.1e-74 251.3 0.0 1.3e-74 251.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Ribosomal_L11 PF00298.19 CRG86629.1 - 0.087 13.3 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11, RNA binding domain Peptidase_M22 PF00814.25 CRG86630.1 - 7.8e-39 134.0 0.1 3.3e-34 118.8 0.0 3.1 2 1 0 2 2 2 2 Glycoprotease family YycC PF14174.6 CRG86630.1 - 0.027 14.3 0.1 0.15 11.9 0.1 2.2 2 0 0 2 2 2 0 YycC-like protein Myb_DNA-bind_6 PF13921.6 CRG86631.1 - 7.8e-08 32.5 1.0 3.6e-07 30.3 0.3 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG86631.1 - 0.00063 19.9 0.1 0.00063 19.9 0.1 2.0 2 1 0 2 2 2 1 Myb-like DNA-binding domain zf-HC5HC2H_2 PF13832.6 CRG86633.1 - 5.6e-32 110.2 7.2 5.6e-32 110.2 7.2 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 CRG86633.1 - 1.1e-30 107.2 0.0 2.2e-30 106.1 0.0 1.6 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 CRG86633.1 - 6.4e-27 93.7 4.4 6.4e-27 93.7 4.4 2.7 3 0 0 3 3 3 1 PHD-like zinc-binding domain RRM_1 PF00076.22 CRG86633.1 - 2.9e-20 71.8 0.0 2.2e-19 69.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHD_2 PF13831.6 CRG86633.1 - 3.2e-14 52.2 9.2 1e-13 50.6 3.4 2.6 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 CRG86633.1 - 1.1e-09 38.1 20.5 1.2e-08 34.7 10.0 2.5 2 0 0 2 2 2 2 PHD-finger Bromodomain PF00439.25 CRG86633.1 - 0.0054 16.8 0.0 0.034 14.2 0.0 2.1 2 0 0 2 2 2 1 Bromodomain RRM_5 PF13893.6 CRG86633.1 - 0.0098 15.5 0.0 0.019 14.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-PHD-like PF15446.6 CRG86633.1 - 0.29 10.7 8.7 0.021 14.4 2.2 2.1 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 CRG86633.1 - 0.4 10.6 14.7 0.22 11.5 3.3 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) VRR_NUC PF08774.11 CRG86634.1 - 1.5e-23 82.9 0.0 3.9e-23 81.6 0.0 1.7 1 0 0 1 1 1 1 VRR-NUC domain Ribosomal_S13_N PF08069.12 CRG86635.1 - 4.6e-28 97.0 0.1 9.8e-28 96.0 0.1 1.6 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain FAD_binding_4 PF01565.23 CRG86635.1 - 7.6e-27 93.7 0.0 1.4e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Ribosomal_S15 PF00312.22 CRG86635.1 - 3.2e-13 49.7 0.1 6.3e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 Pox_EPC_I2-L1 PF12575.8 CRG86635.1 - 0.09 13.0 0.1 0.26 11.5 0.1 1.7 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 Fungal_trans PF04082.18 CRG86636.1 - 2.7e-35 121.7 4.9 3.7e-35 121.2 0.0 2.9 3 1 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86636.1 - 0.00019 21.5 10.5 0.0004 20.4 10.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_28 PF00295.17 CRG86637.1 - 1.8e-46 158.7 10.2 3.2e-46 157.9 10.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 FAD_binding_3 PF01494.19 CRG86638.1 - 3.4e-21 75.9 0.0 8.4e-21 74.6 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG86638.1 - 7.8e-09 35.2 0.1 0.0002 20.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG86638.1 - 3e-07 29.9 0.2 4.9e-07 29.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG86638.1 - 2.2e-06 27.8 0.2 5.8e-06 26.5 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG86638.1 - 2.3e-05 23.3 0.4 0.00088 18.1 0.5 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 CRG86638.1 - 0.00026 21.5 0.8 0.028 15.0 0.7 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG86638.1 - 0.00028 20.1 0.2 0.00061 19.0 0.2 1.5 1 1 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 CRG86638.1 - 0.00096 18.8 0.1 0.024 14.3 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase DUF1344 PF07076.11 CRG86638.1 - 0.0037 17.1 0.1 0.15 12.0 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF1344) Thi4 PF01946.17 CRG86638.1 - 0.0044 16.3 0.1 0.0085 15.4 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 CRG86638.1 - 0.0068 15.7 0.1 0.014 14.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CRG86638.1 - 0.02 14.2 0.0 0.038 13.3 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CRG86638.1 - 0.074 12.9 0.1 0.12 12.2 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CRG86638.1 - 0.1 11.9 0.1 0.18 11.1 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CRG86638.1 - 0.14 11.4 0.3 1.7 7.8 0.0 2.6 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 CRG86638.1 - 0.22 10.6 0.2 1.9 7.4 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein 7tm_2 PF00002.24 CRG86639.1 - 3e-05 23.4 5.6 3e-05 23.4 5.6 2.1 1 1 0 2 2 2 2 7 transmembrane receptor (Secretin family) RRM_1 PF00076.22 CRG86640.1 - 2.7e-28 97.6 0.1 3.3e-12 46.1 0.0 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG86640.1 - 2.2e-05 24.2 0.0 0.51 10.2 0.0 3.5 3 0 0 3 3 3 3 Occluded RNA-recognition motif OGG_N PF07934.12 CRG86641.1 - 9.9e-38 128.9 0.0 1.7e-37 128.2 0.0 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 CRG86641.1 - 7.8e-16 58.5 0.0 1.3e-15 57.8 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 CRG86641.1 - 0.015 15.2 0.0 0.036 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif DUF1910 PF08928.10 CRG86641.1 - 0.016 15.2 0.2 0.21 11.6 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1910) Mito_carr PF00153.27 CRG86642.1 - 3.9e-72 238.3 0.2 8e-25 86.6 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 CRG86642.1 - 1.4e-16 60.7 1.8 4.3e-08 33.5 0.1 3.7 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 CRG86642.1 - 1.9e-13 49.2 5.0 4e-06 26.3 0.1 6.0 6 0 0 6 6 6 2 EF-hand domain EF-hand_1 PF00036.32 CRG86642.1 - 3.1e-12 45.1 9.7 1.1e-05 24.6 0.1 5.8 7 0 0 7 7 7 3 EF hand EF-hand_8 PF13833.6 CRG86642.1 - 7e-07 29.0 6.3 0.4 10.6 0.1 5.4 6 1 1 7 7 7 3 EF-hand domain pair EF-hand_5 PF13202.6 CRG86642.1 - 2.6e-06 26.7 3.0 0.0033 16.9 0.1 4.4 4 0 0 4 4 4 2 EF hand EF-hand_9 PF14658.6 CRG86642.1 - 0.041 14.2 0.1 1.7 9.1 0.1 3.2 2 1 1 3 3 3 0 EF-hand domain DUF5321 PF17254.2 CRG86643.1 - 9.7e-66 220.1 3.7 1.4e-65 219.6 3.7 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5321) RAMP4 PF06624.12 CRG86643.1 - 0.025 14.6 0.6 0.11 12.6 0.0 2.2 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF4020 PF13212.6 CRG86643.1 - 0.084 12.7 0.0 0.11 12.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4020) Peptidase_C50 PF03568.17 CRG86644.1 - 2.3e-154 514.3 0.0 4.6e-154 513.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C50 Esterase PF00756.20 CRG86644.1 - 1.3e-47 162.6 0.0 2.3e-47 161.8 0.0 1.4 1 0 0 1 1 1 1 Putative esterase TPR_MalT PF17874.1 CRG86644.1 - 7.3e-07 28.9 6.0 1.4e-05 24.7 0.2 3.4 3 1 1 4 4 4 1 MalT-like TPR region RPN7 PF10602.9 CRG86644.1 - 8.1e-05 22.4 3.4 0.69 9.6 0.1 4.2 3 1 1 4 4 4 2 26S proteasome subunit RPN7 Esterase_phd PF10503.9 CRG86644.1 - 0.0002 20.9 0.0 0.0013 18.3 0.0 2.2 1 1 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CRG86644.1 - 0.00035 20.1 0.9 0.0011 18.5 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family CHAT PF12770.7 CRG86644.1 - 0.00056 19.4 0.0 0.0075 15.7 0.0 2.7 2 0 0 2 2 2 1 CHAT domain Hydrolase_4 PF12146.8 CRG86644.1 - 0.0035 16.6 0.0 0.0095 15.2 0.0 1.7 1 0 0 1 1 1 1 Serine aminopeptidase, S33 TPR_14 PF13428.6 CRG86644.1 - 0.027 15.3 5.5 50 5.1 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Lipase_3 PF01764.25 CRG86644.1 - 0.056 13.3 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.16 CRG86644.1 - 0.13 12.0 0.0 0.5 10.1 0.0 1.9 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CRG86644.1 - 0.16 11.6 0.0 12 5.5 0.0 2.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CRG86644.1 - 0.16 11.8 0.0 0.65 9.8 0.0 2.1 1 1 0 1 1 1 0 alpha/beta hydrolase fold GspL_C PF12693.7 CRG86644.1 - 0.26 11.1 2.3 1.3 8.8 0.1 2.9 3 0 0 3 3 3 0 GspL periplasmic domain TPR_12 PF13424.6 CRG86644.1 - 2.4 8.5 26.0 0.61 10.4 0.6 5.5 6 1 1 7 7 5 0 Tetratricopeptide repeat Xpo1 PF08389.12 CRG86645.1 - 3.4e-41 140.8 1.0 3.4e-41 140.8 1.0 3.3 2 2 2 4 4 4 1 Exportin 1-like protein DUF4844 PF16133.5 CRG86645.1 - 0.0011 19.5 0.5 1.7 9.2 0.1 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF4844) CelTOS PF18659.1 CRG86645.1 - 0.013 15.9 0.6 0.21 12.0 0.1 3.4 4 0 0 4 4 4 0 Cell-traversal protein for ookinetes and sporozoites FGGY_C PF02782.16 CRG86646.1 - 9.7e-33 113.6 0.0 1.5e-32 112.9 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CRG86646.1 - 1.4e-18 67.4 0.0 2.8e-13 50.0 0.0 2.3 2 0 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain Glyco_hydro_125 PF06824.11 CRG86646.1 - 0.14 11.0 0.0 0.47 9.3 0.0 1.7 2 0 0 2 2 2 0 Metal-independent alpha-mannosidase (GH125) Cation_efflux PF01545.21 CRG86647.1 - 1.6e-57 194.5 5.2 2e-57 194.2 5.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CRG86647.1 - 3.8e-07 30.1 0.0 7.4e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Lin0512_fam PF09585.10 CRG86647.1 - 0.14 12.2 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical protein (Lin0512_fam) SIR2 PF02146.17 CRG86648.1 - 1.2e-30 106.8 0.0 2e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 Sir2 family ALF PF03752.13 CRG86648.1 - 0.089 12.8 0.1 0.25 11.3 0.1 1.8 1 0 0 1 1 1 0 Short repeats of unknown function Pkinase PF00069.25 CRG86649.1 - 1.3e-75 254.2 0.0 1.6e-75 253.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86649.1 - 4.1e-37 127.9 0.0 5.9e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG86649.1 - 4.2e-05 22.7 0.0 0.0004 19.4 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CRG86649.1 - 0.001 18.5 1.3 0.0084 15.5 0.0 2.6 2 1 0 3 3 3 1 Kinase-like APH PF01636.23 CRG86649.1 - 0.013 15.4 2.1 0.042 13.8 0.1 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CRG86649.1 - 0.016 14.5 0.4 0.016 14.5 0.4 1.8 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 CRG86649.1 - 0.057 12.5 0.0 0.097 11.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Dicty_CAR PF05462.11 CRG86650.1 - 1.7e-09 37.2 9.0 1.7e-09 37.2 9.0 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor Git3 PF11710.8 CRG86650.1 - 3.8e-07 30.1 13.3 6.7e-07 29.3 13.3 1.3 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Nnf1 PF03980.14 CRG86651.1 - 1.3e-32 112.4 2.5 1.3e-32 112.4 2.5 1.7 1 1 1 2 2 2 1 Nnf1 MCM_N PF14551.6 CRG86651.1 - 0.031 14.9 0.7 0.067 13.8 0.3 1.7 1 1 1 2 2 2 0 MCM N-terminal domain Nup54 PF13874.6 CRG86651.1 - 0.05 13.7 5.4 1.9 8.6 3.4 2.2 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 BAG6 PF12057.8 CRG86651.1 - 0.051 13.2 0.1 0.11 12.2 0.1 1.5 1 0 0 1 1 1 0 BCL2-associated athanogene 6 TMPIT PF07851.13 CRG86651.1 - 0.98 8.6 2.3 1.8 7.8 2.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein SlyX PF04102.12 CRG86651.1 - 1.6 9.4 5.9 18 6.1 1.7 2.9 2 1 1 3 3 3 0 SlyX TPR_17 PF13431.6 CRG86652.1 - 8.2e-05 22.7 3.6 1.1 9.8 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG86652.1 - 0.00017 21.4 0.0 0.79 10.0 0.2 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 CRG86652.1 - 0.00058 19.6 0.1 0.43 10.5 0.2 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 CRG86652.1 - 0.038 14.6 0.4 71 4.4 0.0 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CRG86652.1 - 0.066 12.9 3.3 35 4.2 0.1 4.1 4 0 0 4 4 4 0 TPR repeat TPR_12 PF13424.6 CRG86652.1 - 1 9.7 10.8 5.8 7.3 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat NTF2 PF02136.20 CRG86654.1 - 2.3e-26 92.7 0.2 4.2e-26 91.9 0.2 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 CRG86654.1 - 5.1e-08 32.6 0.0 9.4e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CCDC106 PF15794.5 CRG86654.1 - 0.3 10.8 1.5 0.3 10.8 0.2 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 HSP90 PF00183.18 CRG86655.1 - 3.8e-221 735.5 34.5 4.9e-221 735.1 34.5 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 CRG86655.1 - 3.2e-15 56.6 0.1 5.9e-15 55.7 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CRG86655.1 - 2.7e-11 43.5 0.2 2.7e-11 43.5 0.2 2.2 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase UPF0113_N PF17833.1 CRG86655.1 - 0.12 13.0 4.0 1.2 9.7 0.0 3.9 4 1 0 4 4 4 0 UPF0113 Pre-PUA domain DinB PF05163.12 CRG86655.1 - 0.9 9.4 3.4 3.2 7.7 2.4 2.3 2 0 0 2 2 2 0 DinB family DUF1676 PF07898.13 CRG86655.1 - 2.1 8.4 6.1 2 8.4 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Septin PF00735.18 CRG86656.1 - 5.5e-11 42.3 0.0 1.4e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 Septin MMR_HSR1 PF01926.23 CRG86656.1 - 0.043 13.9 0.0 0.11 12.6 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase HLH PF00010.26 CRG86657.1 - 2.7e-14 52.9 0.2 5.4e-14 51.9 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GN3L_Grn1 PF08701.11 CRG86657.1 - 0.0037 17.3 3.6 0.013 15.6 3.6 1.9 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase DUF4770 PF15994.5 CRG86657.1 - 0.26 11.5 9.9 4 7.6 4.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF4470 PF14737.6 CRG86658.1 - 2.5e-10 40.4 0.0 5.5e-10 39.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) TPR_2 PF07719.17 CRG86658.1 - 6.5e-07 29.0 12.5 0.0014 18.6 0.1 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG86658.1 - 8.9e-07 28.5 3.9 0.001 18.7 0.5 2.5 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 CRG86658.1 - 1.7e-05 24.5 4.8 0.011 15.5 0.5 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG86658.1 - 2.4e-05 24.5 9.4 0.00014 22.0 2.7 3.3 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG86658.1 - 0.00047 19.6 2.6 0.00094 18.6 2.6 1.4 1 0 0 1 1 1 1 MalT-like TPR region TPR_19 PF14559.6 CRG86658.1 - 0.0015 19.0 2.9 0.071 13.6 0.4 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 CRG86658.1 - 0.0044 17.1 5.0 0.63 10.4 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG86658.1 - 0.0044 17.7 7.9 4.9 8.2 0.3 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG86658.1 - 0.0054 16.6 2.1 0.16 11.9 0.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CRG86658.1 - 0.0055 17.3 9.8 0.089 13.5 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG86658.1 - 0.024 14.6 2.4 0.14 12.3 0.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Antimicrobial_3 PF08025.11 CRG86658.1 - 0.099 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Spider antimicrobial peptide TPR_3 PF07720.12 CRG86658.1 - 0.14 12.2 7.0 4.8 7.3 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 CRG86658.1 - 0.15 12.1 0.3 0.71 9.9 0.3 2.0 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) YrhC PF14143.6 CRG86658.1 - 0.17 12.0 0.2 0.47 10.6 0.2 1.7 1 0 0 1 1 1 0 YrhC-like protein SpoIIE PF07228.12 CRG86659.1 - 0.0017 18.3 0.0 0.017 15.1 0.0 2.6 2 1 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 CRG86659.1 - 0.026 14.1 0.1 0.24 11.0 0.0 2.0 2 0 0 2 2 2 0 Protein phosphatase 2C PP2C_2 PF13672.6 CRG86659.1 - 0.031 13.9 0.0 0.054 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein phosphatase 2C O-ag_pol_Wzy PF14296.6 CRG86660.1 - 5.9 5.4 11.7 0.038 12.6 1.0 2.4 3 0 0 3 3 3 0 O-antigen polysaccharide polymerase Wzy Fcf1 PF04900.12 CRG86661.1 - 2.8e-16 59.7 0.1 6.8e-15 55.3 0.1 2.3 1 1 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 CRG86661.1 - 0.083 13.2 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 PIN like domain DUF4551 PF15087.6 CRG86661.1 - 9 5.0 7.9 13 4.5 7.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Cmc1 PF08583.10 CRG86662.1 - 3.2e-18 65.5 5.1 4.1e-18 65.2 5.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like VEG PF06257.11 CRG86662.1 - 0.026 14.6 0.1 0.035 14.1 0.1 1.2 1 0 0 1 1 1 0 Biofilm formation stimulator VEG ProSAAS PF07259.12 CRG86662.1 - 0.19 11.7 1.5 0.18 11.8 1.5 1.1 1 0 0 1 1 1 0 ProSAAS precursor WD40 PF00400.32 CRG86663.1 - 1.5e-17 63.7 7.0 0.0018 19.1 0.2 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 CRG86663.1 - 2.2e-05 23.4 1.9 0.0018 17.1 0.3 2.6 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 CRG86663.1 - 5.4e-05 23.4 1.2 0.046 14.0 0.1 4.5 4 1 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4241 PF14025.6 CRG86663.1 - 0.012 15.9 1.4 0.029 14.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4241) RRN3 PF05327.11 CRG86665.1 - 1.5e-177 591.6 0.0 2.2e-177 591.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_3 PF07859.13 CRG86666.1 - 1.3e-45 155.9 0.0 1.6e-45 155.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CRG86666.1 - 3e-08 33.0 0.1 1.1e-07 31.1 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CRG86666.1 - 0.00013 21.5 0.2 0.019 14.4 0.1 2.5 2 1 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CRG86666.1 - 0.00073 20.2 2.6 0.00073 20.2 2.6 1.4 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF2974 PF11187.8 CRG86666.1 - 0.0053 16.3 0.0 0.0076 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_2 PF02230.16 CRG86666.1 - 0.0058 16.5 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 CRG86666.1 - 0.017 13.8 0.0 1 8.0 0.0 2.1 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) Say1_Mug180 PF10340.9 CRG86666.1 - 0.089 11.6 0.0 0.18 10.6 0.0 1.5 1 0 0 1 1 1 0 Steryl acetyl hydrolase Esterase PF00756.20 CRG86666.1 - 0.16 11.6 1.5 0.84 9.2 1.5 1.9 1 1 0 1 1 1 0 Putative esterase Esterase_phd PF10503.9 CRG86666.1 - 0.16 11.4 0.3 0.44 10.0 0.1 1.7 2 0 0 2 2 2 0 Esterase PHB depolymerase Lipase_3 PF01764.25 CRG86666.1 - 0.21 11.5 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) tRNA-synt_2 PF00152.20 CRG86667.1 - 1e-68 231.8 0.0 1.7e-68 231.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 CRG86667.1 - 8.4e-19 67.7 0.0 1.2e-18 67.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA-synt_2d PF01409.20 CRG86667.1 - 0.021 14.3 0.2 7.5 5.9 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 CRG86667.1 - 0.025 14.6 0.4 0.059 13.4 0.1 1.8 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain p450 PF00067.22 CRG86669.1 - 1.8e-68 231.4 0.0 2.4e-68 231.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Cyt-b5 PF00173.28 CRG86670.1 - 2.6e-22 78.7 0.0 4.2e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FSH1 PF03959.13 CRG86671.1 - 9.6e-26 90.7 0.0 4e-25 88.7 0.0 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 CRG86671.1 - 5.7e-05 23.8 0.0 7.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family FAD_binding_3 PF01494.19 CRG86672.1 - 1.9e-13 50.4 0.1 5.1e-13 49.0 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG86672.1 - 0.0016 17.7 0.2 0.068 12.4 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CRG86672.1 - 0.0026 16.9 0.0 1.4 7.9 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase NAD_binding_8 PF13450.6 CRG86672.1 - 0.023 14.9 0.3 0.06 13.6 0.3 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG86672.1 - 0.045 13.8 0.3 0.21 11.6 0.1 2.3 2 1 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CRG86673.1 - 1.8e-18 66.9 2.3 1.4e-16 60.7 2.3 2.6 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG86673.1 - 1.3e-06 28.3 0.6 0.0002 21.1 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG86673.1 - 6.2e-06 26.4 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG86673.1 - 8.5e-06 25.2 0.0 0.061 12.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG86673.1 - 1.6e-05 24.2 0.2 9.7e-05 21.6 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CRG86673.1 - 1.9e-05 25.1 0.0 0.0043 17.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG86673.1 - 2.9e-05 23.6 0.2 0.011 15.0 0.0 2.6 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CRG86673.1 - 0.003 16.3 0.1 0.18 10.5 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 CRG86673.1 - 0.0042 16.4 0.1 0.39 9.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG86673.1 - 0.0055 16.0 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 CRG86673.1 - 0.021 13.9 0.1 0.042 12.9 0.1 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 CRG86673.1 - 0.029 13.7 0.1 0.064 12.6 0.1 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG86673.1 - 0.17 10.9 0.4 3.7 6.5 0.1 2.3 2 0 0 2 2 2 0 Lycopene cyclase protein ketoacyl-synt PF00109.26 CRG86674.1 - 1.5e-73 247.5 0.0 3.1e-73 246.5 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 CRG86674.1 - 1.7e-43 149.1 0.2 2.2e-41 142.2 0.0 2.8 2 1 1 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 CRG86674.1 - 1.8e-40 139.4 0.0 3.3e-40 138.6 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG86674.1 - 1e-31 109.4 0.2 2.1e-31 108.4 0.2 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CRG86674.1 - 4.6e-11 42.9 0.2 1.6e-10 41.2 0.2 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CRG86674.1 - 1.3e-08 35.3 0.0 3e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CRG86674.1 - 7.3e-05 22.3 0.1 0.00021 20.8 0.0 1.7 2 0 0 2 2 2 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CRG86674.1 - 0.73 9.7 2.6 1 9.3 0.2 2.5 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III MFS_1 PF07690.16 CRG86675.1 - 2.9e-42 144.8 40.0 2.9e-42 144.8 40.0 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86675.1 - 6.9e-11 41.7 10.7 6.9e-11 41.7 10.7 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 CRG86675.1 - 0.15 10.3 9.4 0.052 11.8 2.0 2.6 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DLH PF01738.18 CRG86676.1 - 5.2e-11 42.5 0.0 6e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Fungal_trans PF04082.18 CRG86677.1 - 1.3e-22 80.1 4.0 2.1e-22 79.5 4.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG86678.1 - 1.1e-14 54.4 0.7 1.5e-14 53.9 0.7 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86678.1 - 1.6e-10 41.0 1.2 1.9e-10 40.7 1.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86678.1 - 1.8e-06 28.0 0.2 4.3e-06 26.8 0.3 1.6 2 0 0 2 2 2 1 KR domain NmrA PF05368.13 CRG86678.1 - 5.9e-05 22.7 3.3 0.00011 21.9 3.3 1.4 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG86678.1 - 0.00014 21.8 1.0 0.00014 21.8 1.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 CRG86678.1 - 0.0057 16.2 0.2 0.015 14.8 0.1 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG86678.1 - 0.023 14.1 0.1 0.037 13.4 0.1 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase F420_oxidored PF03807.17 CRG86678.1 - 0.032 14.8 0.7 0.078 13.6 0.4 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent PALP PF00291.25 CRG86678.1 - 0.24 10.8 2.6 0.59 9.5 2.7 1.5 1 1 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme AflR PF08493.10 CRG86679.1 - 9.4e-34 117.2 3.7 9.4e-34 117.2 3.7 1.5 2 0 0 2 2 2 1 Aflatoxin regulatory protein Zn_clus PF00172.18 CRG86679.1 - 1.2e-08 34.9 11.2 1.2e-08 34.9 11.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactamase_B PF00753.27 CRG86680.1 - 2.6e-17 63.5 6.0 4.2e-15 56.3 6.0 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG86680.1 - 7.9e-05 22.3 0.1 0.00014 21.5 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CRG86680.1 - 0.00028 20.4 0.0 0.0004 19.9 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CRG86680.1 - 0.0034 17.3 0.0 0.0054 16.6 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Cu-oxidase_2 PF07731.14 CRG86681.1 - 4.4e-35 120.4 3.8 9.2e-27 93.5 0.0 3.8 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG86681.1 - 7e-33 113.2 0.5 4.2e-32 110.7 0.2 2.5 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG86681.1 - 4e-16 59.5 0.0 1.9e-15 57.3 0.0 2.2 1 1 0 1 1 1 1 Multicopper oxidase SoxE PF06525.11 CRG86681.1 - 0.029 13.8 1.3 9.5 5.7 0.1 3.3 3 0 0 3 3 3 0 Sulfocyanin (SoxE) domain BPA_C PF18040.1 CRG86681.1 - 0.036 14.0 0.0 0.86 9.6 0.0 2.3 2 0 0 2 2 2 0 beta porphyranase A C-terminal Lectin_like PF18560.1 CRG86681.1 - 0.053 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Lectin like domain adh_short_C2 PF13561.6 CRG86682.1 - 1.8e-54 184.8 0.6 2.4e-54 184.4 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86682.1 - 4.1e-47 160.2 1.1 5.1e-47 159.9 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86682.1 - 8.7e-11 42.1 0.4 1.1e-10 41.7 0.4 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG86682.1 - 0.0012 18.3 0.0 0.0021 17.5 0.0 1.4 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CRG86682.1 - 0.029 13.8 0.3 0.25 10.8 0.3 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family EthD PF07110.11 CRG86683.1 - 1.5e-17 64.5 0.4 2e-17 64.1 0.4 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 CRG86683.1 - 0.057 13.9 0.1 0.077 13.5 0.1 1.2 1 0 0 1 1 1 0 Methylmuconolactone methyl-isomerase Scytalone_dh PF02982.14 CRG86684.1 - 6.3e-68 227.6 2.1 7e-68 227.4 2.1 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 CRG86684.1 - 5.3e-08 33.1 0.7 6.6e-08 32.7 0.7 1.1 1 0 0 1 1 1 1 SnoaL-like domain ADH_N PF08240.12 CRG86685.1 - 1.2e-21 76.6 0.0 2.4e-21 75.7 0.0 1.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG86685.1 - 1.3e-10 41.3 0.0 2.3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG86685.1 - 8.3e-05 23.6 0.0 0.00021 22.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ABM PF03992.16 CRG86686.1 - 3e-10 40.1 0.0 3.9e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Phage_holin_3_6 PF07332.11 CRG86687.1 - 0.5 10.4 7.1 0.31 11.1 0.4 2.4 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III FAD_binding_4 PF01565.23 CRG86689.1 - 2.3e-19 69.5 3.6 5e-19 68.4 3.6 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG86689.1 - 7.5e-06 25.9 0.4 1.6e-05 24.9 0.4 1.6 1 0 0 1 1 1 1 Berberine and berberine like DUF3328 PF11807.8 CRG86690.1 - 8.9e-26 91.0 0.1 1.1e-25 90.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Glyco_hydro_11 PF00457.17 CRG86691.1 - 4.1e-63 212.2 14.4 5.8e-63 211.7 14.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 CBM_1 PF00734.18 CRG86691.1 - 4.1e-13 49.0 4.1 1.1e-12 47.6 4.1 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain LysM PF01476.20 CRG86693.1 - 5.6e-10 39.1 0.1 9e-06 25.7 0.0 3.2 3 0 0 3 3 3 2 LysM domain Glyco_hydro_18 PF00704.28 CRG86694.1 - 6.8e-42 144.3 0.2 1.2e-41 143.5 0.2 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 adh_short PF00106.25 CRG86695.1 - 1.4e-09 37.7 0.0 1.3e-07 31.2 0.0 2.7 1 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86695.1 - 0.0032 17.1 0.0 0.0092 15.6 0.0 1.8 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NuA4 PF09340.10 CRG86695.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Histone acetyltransferase subunit NuA4 Sulfotransfer_4 PF17784.1 CRG86696.1 - 3.3e-66 223.2 0.1 3.9e-66 223.0 0.1 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 CRG86696.1 - 0.0033 17.8 0.2 1 9.7 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Carb_anhydrase PF00194.21 CRG86697.1 - 5e-35 121.2 0.1 8.6e-35 120.5 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Cu-oxidase_2 PF07731.14 CRG86698.1 - 3.8e-39 133.6 8.1 2e-38 131.2 0.3 3.0 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG86698.1 - 3.3e-36 123.9 3.1 3.3e-36 123.9 3.1 2.2 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG86698.1 - 2.5e-32 112.2 1.0 7e-32 110.7 0.5 2.0 2 0 0 2 2 2 1 Multicopper oxidase DUF3176 PF11374.8 CRG86700.1 - 4.8e-13 49.3 11.0 4.8e-13 49.3 11.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) Cytochrome_cB PF11783.8 CRG86701.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c bacterial SWIRM PF04433.17 CRG86702.1 - 1.6e-11 44.3 0.0 3e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain Bact_transglu_N PF08379.10 CRG86702.1 - 0.2 12.6 0.9 1 10.3 0.9 2.2 1 1 0 1 1 1 0 Bacterial transglutaminase-like N-terminal region CDC50 PF03381.15 CRG86703.1 - 5.5e-95 318.1 0.0 8.6e-95 317.4 0.0 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Peptidase_M43 PF05572.13 CRG86703.1 - 1.3e-11 44.7 0.1 8.4e-11 42.0 0.1 2.2 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CRG86703.1 - 0.14 12.3 2.4 0.19 11.9 0.9 2.0 2 0 0 2 2 2 0 Metallo-peptidase family M12 SPT16 PF08644.11 CRG86704.1 - 4.7e-58 195.7 0.1 1.4e-57 194.1 0.1 1.9 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 CRG86704.1 - 1.3e-52 177.9 0.0 3.5e-52 176.5 0.0 1.8 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 CRG86704.1 - 7.6e-26 91.1 0.0 1.4e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 CRG86704.1 - 3.7e-15 56.1 0.5 1.4e-14 54.3 0.0 2.2 2 0 0 2 2 2 1 Histone chaperone Rttp106-like Sugar_tr PF00083.24 CRG86705.1 - 1.2e-101 340.8 12.4 1.7e-101 340.3 12.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86705.1 - 1.4e-29 103.2 48.4 4.6e-28 98.2 21.7 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Mito_carr PF00153.27 CRG86705.1 - 9.5e-14 51.1 0.1 1.3e-10 41.0 0.1 3.0 2 1 0 2 2 2 2 Mitochondrial carrier protein MFS_2 PF13347.6 CRG86705.1 - 1.1e-06 27.5 19.8 5.5e-06 25.2 5.2 2.6 3 0 0 3 3 3 2 MFS/sugar transport protein APH PF01636.23 CRG86706.1 - 6.5e-11 42.6 0.3 1.5e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family zf-AN1 PF01428.16 CRG86706.1 - 0.0008 19.5 8.0 0.0015 18.7 8.0 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 CRG86706.1 - 0.3 11.5 3.5 0.54 10.6 3.5 1.4 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain PMT PF02366.18 CRG86707.1 - 6.2e-73 245.4 16.8 3.8e-71 239.5 16.8 2.5 1 1 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CRG86707.1 - 3.3e-64 216.1 13.0 3.3e-64 216.1 13.0 2.4 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CRG86707.1 - 6e-37 127.3 0.4 9.6e-37 126.6 0.4 1.2 1 0 0 1 1 1 1 MIR domain Ras PF00071.22 CRG86708.1 - 2.4e-47 160.5 0.0 1.4e-36 125.5 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 CRG86708.1 - 1e-28 100.0 0.0 2.1e-18 66.7 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG86708.1 - 7.5e-11 41.8 0.0 3.9e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG86708.1 - 5.1e-07 29.4 0.0 9.3e-06 25.3 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CRG86708.1 - 8.4e-07 28.6 0.0 1.6e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CRG86708.1 - 8.5e-05 22.6 0.1 0.0016 18.5 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG86708.1 - 0.0011 18.9 0.0 0.29 11.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CRG86708.1 - 0.059 13.7 0.0 0.63 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CRG86708.1 - 0.087 12.4 0.1 13 5.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF1639 PF07797.14 CRG86708.1 - 0.13 12.3 1.2 0.26 11.3 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) AAA_16 PF13191.6 CRG86708.1 - 0.15 12.4 0.2 0.51 10.7 0.2 2.0 1 1 0 1 1 1 0 AAA ATPase domain Choline_transpo PF04515.12 CRG86709.1 - 1.7e-26 93.2 23.5 1.7e-26 93.2 23.5 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter TPT PF03151.16 CRG86711.1 - 5.7e-62 209.7 16.6 6.9e-62 209.4 16.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CRG86711.1 - 3.8e-10 40.1 31.5 7.2e-06 26.2 10.4 2.7 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 CRG86711.1 - 0.007 15.6 18.7 0.013 14.7 18.7 1.4 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 CRG86711.1 - 2.6 7.2 20.3 15 4.7 20.2 2.0 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport PUF PF00806.19 CRG86712.1 - 6.7e-34 113.7 4.2 8.6e-06 25.2 0.0 8.7 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat DUF5572 PF17733.1 CRG86713.1 - 2.5e-23 81.6 0.3 6e-23 80.4 0.3 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Ssl1 PF04056.14 CRG86714.1 - 5e-76 254.8 0.0 6.5e-76 254.4 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 CRG86714.1 - 7.9e-19 67.6 8.8 7.9e-19 67.6 8.8 2.2 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 CRG86714.1 - 6e-17 62.2 0.0 1.5e-16 61.0 0.0 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 CRG86714.1 - 4.8e-08 33.4 0.0 9.5e-08 32.5 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain DZR PF12773.7 CRG86714.1 - 2.1 8.4 25.6 13 5.9 9.1 3.2 2 1 0 2 2 2 0 Double zinc ribbon ERAP1_C PF11838.8 CRG86715.1 - 5.6e-87 292.2 1.6 7.5e-87 291.8 0.2 1.9 3 0 0 3 3 3 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CRG86715.1 - 3.3e-82 275.3 5.1 4.8e-82 274.8 5.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CRG86715.1 - 5.4e-44 150.6 0.0 4.3e-43 147.7 0.0 2.3 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF45 PF01863.17 CRG86715.1 - 0.12 12.4 0.0 0.5 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF45 Mito_carr PF00153.27 CRG86716.1 - 1.7e-53 178.5 1.8 2.1e-17 62.8 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein TadE PF07811.12 CRG86716.1 - 0.013 15.8 1.0 2.4 8.5 0.1 2.7 2 0 0 2 2 2 0 TadE-like protein UcrQ PF02939.16 CRG86716.1 - 0.023 14.6 0.1 0.078 12.9 0.1 2.0 1 0 0 1 1 1 0 UcrQ family PrcB_C PF14343.6 CRG86716.1 - 0.12 12.6 0.0 4 7.6 0.1 2.3 2 0 0 2 2 2 0 PrcB C-terminal WD40 PF00400.32 CRG86717.1 - 2.7e-10 40.6 14.4 0.028 15.3 0.0 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat WW PF00397.26 CRG86718.1 - 4.6e-11 42.6 1.2 9e-11 41.7 1.2 1.5 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 CRG86718.1 - 0.16 12.0 48.7 0.12 12.4 39.5 3.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) AMP-binding PF00501.28 CRG86719.1 - 5.9e-80 268.9 0.0 8.1e-80 268.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme DUF2012 PF09430.10 CRG86719.1 - 2.2e-31 108.5 0.0 3.7e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) AA_permease PF00324.21 CRG86720.1 - 1.7e-139 465.6 50.1 1.9e-139 465.3 50.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG86720.1 - 7.5e-34 117.3 55.0 9.2e-34 117.0 55.0 1.0 1 0 0 1 1 1 1 Amino acid permease MARVEL PF01284.23 CRG86721.1 - 1.4e-21 77.0 15.0 1.8e-21 76.7 15.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain Cys_Met_Meta_PP PF01053.20 CRG86722.1 - 2.8e-151 503.4 0.0 3.1e-151 503.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CRG86722.1 - 1.1e-10 41.4 1.7 1.3e-10 41.1 1.0 1.4 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 CRG86722.1 - 1e-08 34.8 0.1 4.1e-08 32.8 0.1 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CRG86722.1 - 8.1e-07 28.6 0.0 1.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CRG86722.1 - 2.7e-06 26.6 0.7 4.5e-06 25.9 0.7 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Met_gamma_lyase PF06838.11 CRG86722.1 - 0.0057 15.2 0.1 0.0072 14.9 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.16 CRG86722.1 - 0.014 14.2 0.0 0.02 13.7 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein Asparaginase_C PF17763.1 CRG86722.1 - 0.016 15.4 0.0 0.053 13.7 0.0 1.9 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain SepSecS PF05889.13 CRG86722.1 - 0.03 13.0 0.0 0.043 12.5 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS CTD_bind PF04818.13 CRG86723.1 - 2.8e-09 37.6 0.0 5.1e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_1 PF00076.22 CRG86723.1 - 3.8e-05 23.4 0.0 6.4e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Citrate_synt PF00285.21 CRG86724.1 - 7.8e-102 341.0 0.0 1e-101 340.7 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 CRG86724.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone Mito_carr PF00153.27 CRG86725.1 - 2.8e-26 91.3 2.5 3.9e-12 45.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans PF04082.18 CRG86726.1 - 1.5e-08 34.0 0.0 3.2e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86726.1 - 1.5 9.0 7.8 2.6 8.2 7.8 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Cwf_Cwc_15 PF04889.12 CRG86726.1 - 1.8 8.2 6.4 0.33 10.7 2.7 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Peptidase_M16 PF00675.20 CRG86727.1 - 4.4e-16 59.2 0.0 7.7e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CRG86727.1 - 1.1e-13 51.7 0.0 2.7e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Peptidase M16 inactive domain RNA_pol_Rpc82 PF05645.13 CRG86728.1 - 1e-28 100.9 0.0 2e-28 99.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 CRG86728.1 - 7.3e-11 42.0 2.8 1.1e-08 35.0 0.1 3.3 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 CRG86728.1 - 0.0022 17.8 0.2 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 TFIIE alpha subunit Pga1 PF10333.9 CRG86729.1 - 0.00044 20.1 1.1 0.0017 18.2 1.1 2.0 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Tubulin PF00091.25 CRG86730.1 - 2.5e-56 191.0 0.0 4e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CRG86730.1 - 3.5e-49 166.1 0.1 6.1e-49 165.4 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CRG86730.1 - 0.0022 17.7 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain EF-hand_4 PF12763.7 CRG86731.1 - 1.3e-40 137.5 0.0 2.1e-15 56.5 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 CRG86731.1 - 1.4e-08 34.4 0.7 2.6e-08 33.6 0.0 1.9 2 0 0 2 2 1 1 UBA/TS-N domain EF-hand_1 PF00036.32 CRG86731.1 - 2.2e-08 33.1 2.8 0.0022 17.4 0.0 4.8 6 0 0 6 6 5 2 EF hand EF-hand_7 PF13499.6 CRG86731.1 - 2.4e-08 34.3 0.0 0.0049 17.3 0.0 4.4 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 CRG86731.1 - 4.2e-07 29.4 0.5 0.58 10.2 0.0 6.3 7 0 0 7 7 7 2 EF-hand domain Spc7 PF08317.11 CRG86731.1 - 0.0003 19.8 31.5 0.0098 14.8 15.9 2.1 1 1 1 2 2 2 2 Spc7 kinetochore protein EF-hand_8 PF13833.6 CRG86731.1 - 0.00035 20.4 0.2 0.61 10.0 0.1 4.0 3 1 1 4 4 3 1 EF-hand domain pair DUF812 PF05667.11 CRG86731.1 - 0.0039 16.1 14.0 0.0097 14.8 14.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF812) GAS PF13851.6 CRG86731.1 - 0.0046 16.3 26.6 0.056 12.8 12.8 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding FUSC PF04632.12 CRG86731.1 - 0.45 9.0 10.5 0.69 8.4 10.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family Atg14 PF10186.9 CRG86731.1 - 0.54 9.3 19.0 1.1 8.3 19.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3450 PF11932.8 CRG86731.1 - 1.1 8.5 31.4 0.018 14.3 12.2 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 CRG86731.1 - 1.3 9.1 37.1 1.1 9.4 18.0 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 CRG86731.1 - 3 8.1 25.2 2.4 8.4 4.7 3.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 CRG86731.1 - 3.7 6.8 29.1 0.35 10.2 3.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 CRG86731.1 - 7 6.7 31.2 18 5.4 13.5 3.4 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Filament PF00038.21 CRG86731.1 - 7.3 6.1 29.8 1.8 8.0 13.3 2.1 1 1 1 2 2 2 0 Intermediate filament protein ADH_zinc_N_2 PF13602.6 CRG86733.1 - 5.8e-12 46.8 0.0 2.1e-11 45.0 0.0 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG86733.1 - 5.9e-11 42.5 0.0 1.2e-10 41.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ORC5_C PF14630.6 CRG86734.1 - 9.7e-82 274.7 0.0 1.3e-81 274.3 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 CRG86734.1 - 7e-18 65.6 0.2 1.2e-17 64.8 0.2 1.4 1 0 0 1 1 1 1 AAA ATPase domain PUF PF00806.19 CRG86735.1 - 2.3e-59 193.9 2.9 5.6e-08 32.1 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat RNA_pol_Rpb2_6 PF00562.28 CRG86736.1 - 4.6e-124 414.4 0.0 9.7e-124 413.4 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CRG86736.1 - 8.9e-54 182.1 0.3 1.3e-53 181.5 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 CRG86736.1 - 9.3e-32 109.3 0.4 2.1e-31 108.1 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 CRG86736.1 - 1.6e-28 99.7 4.1 3.4e-28 98.6 4.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 CRG86736.1 - 6.3e-23 80.8 0.4 1.6e-22 79.5 0.4 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 CRG86736.1 - 2.2e-19 69.4 0.0 5.6e-19 68.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 CRG86736.1 - 4e-10 40.1 1.8 2.4e-09 37.6 1.8 2.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 NRDD PF13597.6 CRG86736.1 - 0.19 10.4 0.4 0.33 9.7 0.4 1.2 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase zn-ribbon_14 PF16503.5 CRG86736.1 - 3 7.4 6.1 0.31 10.6 1.5 1.8 2 0 0 2 2 2 0 Zinc-ribbon DUF4246 PF14033.6 CRG86737.1 - 2.3e-105 353.3 0.0 8.3e-70 236.1 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) RE_HaeIII PF09556.10 CRG86737.1 - 0.058 12.5 0.1 0.095 11.8 0.1 1.3 1 0 0 1 1 1 0 HaeIII restriction endonuclease DUF829 PF05705.14 CRG86738.1 - 1.8e-44 152.5 0.0 2.4e-44 152.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) UFD1 PF03152.14 CRG86739.1 - 3.3e-75 251.3 0.0 4e-75 251.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 GYF PF02213.16 CRG86740.1 - 1e-14 53.9 2.6 2.4e-14 52.7 2.6 1.6 1 0 0 1 1 1 1 GYF domain TIP49 PF06068.13 CRG86741.1 - 3e-154 513.5 2.4 3e-154 513.5 2.4 1.5 2 0 0 2 2 2 1 TIP49 P-loop domain TIP49_C PF17856.1 CRG86741.1 - 1.6e-21 76.2 0.6 5.8e-21 74.4 0.3 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain RuvB_N PF05496.12 CRG86741.1 - 2.2e-08 34.0 0.6 1.6e-05 24.7 0.1 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 CRG86741.1 - 2.8e-08 34.3 1.2 5.6e-05 23.6 0.1 2.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 CRG86741.1 - 8.3e-07 28.6 0.9 1.7e-06 27.5 0.9 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 CRG86741.1 - 1.5e-06 28.7 0.8 9.9e-06 26.0 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.21 CRG86741.1 - 0.0041 16.5 0.8 0.056 12.8 0.4 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 CRG86741.1 - 0.0043 17.3 0.1 0.8 10.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 CRG86741.1 - 0.0045 16.7 0.0 2.5 7.8 0.1 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_5 PF07728.14 CRG86741.1 - 0.013 15.4 0.6 1.9 8.5 0.0 3.2 3 1 1 4 4 4 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 CRG86741.1 - 0.017 14.7 0.1 0.035 13.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 CRG86741.1 - 0.028 14.8 1.9 0.4 11.0 1.9 2.4 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CRG86741.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CRG86741.1 - 0.048 13.4 0.3 0.18 11.6 0.0 1.9 1 1 1 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 CRG86741.1 - 0.088 11.9 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 CRG86741.1 - 0.088 13.0 0.1 0.22 11.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain TFIID-31kDa PF02291.15 CRG86741.1 - 0.091 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit AAA_7 PF12775.7 CRG86741.1 - 0.12 11.9 0.2 0.5 9.9 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region Hydin_ADK PF17213.3 CRG86741.1 - 0.12 12.7 0.8 0.27 11.5 0.7 1.8 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain ANAPC16 PF17256.2 CRG86742.1 - 0.044 14.1 0.4 0.29 11.5 0.4 2.4 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 16 CotJB PF12652.7 CRG86742.1 - 0.067 13.4 0.1 0.61 10.3 0.1 2.7 1 0 0 1 1 1 0 CotJB protein Hemerythrin PF01814.23 CRG86742.1 - 1.1 9.9 10.6 0.065 13.9 0.7 3.7 4 0 0 4 4 4 0 Hemerythrin HHE cation binding domain Csa1 PF06023.12 CRG86742.1 - 8.6 5.6 10.1 1.1 8.6 0.1 3.4 3 1 0 3 3 3 0 CRISPR-associated exonuclease Csa1 Abhydrolase_1 PF00561.20 CRG86743.1 - 1.1e-18 67.9 0.0 3.4e-14 53.1 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG86743.1 - 3.5e-15 57.2 0.0 4.8e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG86743.1 - 2.4e-10 40.1 0.0 4.7e-10 39.1 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CRG86743.1 - 1.2e-06 28.8 0.0 1.8e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain DUF676 PF05057.14 CRG86743.1 - 7.3e-06 25.6 0.0 1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 CRG86743.1 - 8.7e-06 25.6 0.6 0.0011 18.7 0.6 2.3 1 1 0 1 1 1 1 PGAP1-like protein Esterase PF00756.20 CRG86743.1 - 0.0019 17.9 0.0 0.0033 17.1 0.0 1.5 1 1 0 1 1 1 1 Putative esterase Palm_thioest PF02089.15 CRG86743.1 - 0.0031 17.4 0.0 0.0038 17.1 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Ndr PF03096.14 CRG86743.1 - 0.0035 16.1 0.0 0.0046 15.7 0.0 1.4 1 1 0 1 1 1 1 Ndr family Abhydrolase_3 PF07859.13 CRG86743.1 - 0.014 15.3 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 CRG86743.1 - 0.025 14.4 0.0 0.038 13.9 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Chlorophyllase2 PF12740.7 CRG86743.1 - 0.031 13.2 0.0 0.064 12.2 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase enzyme Abi_C PF14355.6 CRG86743.1 - 0.047 13.8 0.2 0.097 12.8 0.2 1.5 1 0 0 1 1 1 0 Abortive infection C-terminus DUF915 PF06028.11 CRG86743.1 - 0.056 12.8 0.1 11 5.2 0.0 2.5 1 1 1 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydro_lipase PF04083.16 CRG86743.1 - 0.1 12.2 0.1 0.39 10.3 0.0 1.9 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region LCAT PF02450.15 CRG86743.1 - 0.13 11.5 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase B12-binding PF02310.19 CRG86744.1 - 0.0013 18.7 0.1 0.0021 18.1 0.1 1.3 1 0 0 1 1 1 1 B12 binding domain FtsK_SpoIIIE PF01580.18 CRG86744.1 - 0.0067 15.8 0.0 0.0069 15.8 0.0 1.1 1 0 0 1 1 1 1 FtsK/SpoIIIE family Lant_dehydr_N PF04738.13 CRG86744.1 - 0.026 12.6 0.0 0.028 12.5 0.0 1.0 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus FAA_hydrolase PF01557.18 CRG86745.1 - 3.3e-50 170.8 0.0 4.6e-50 170.3 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Tnp_P_element_C PF12596.8 CRG86745.1 - 0.12 13.0 0.0 0.19 12.3 0.0 1.3 1 0 0 1 1 1 0 87kDa Transposase Methyltransf_3 PF01596.17 CRG86746.1 - 5.5e-13 48.6 0.0 7.5e-13 48.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CRG86746.1 - 2.5e-10 41.3 0.0 4.3e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 CRG86746.1 - 0.0016 18.2 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Cephalosporin hydroxylase DUF4108 PF13390.6 CRG86746.1 - 0.16 11.9 0.0 15 5.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) Aldo_ket_red PF00248.21 CRG86747.1 - 2.8e-59 200.7 0.0 3.6e-59 200.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family TPR_10 PF13374.6 CRG86747.1 - 0.047 13.6 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Pam16 PF03656.13 CRG86748.1 - 5.4e-32 110.5 0.3 6.6e-32 110.2 0.3 1.0 1 0 0 1 1 1 1 Pam16 Peptidase_S77 PF03420.13 CRG86748.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.5 2 0 0 2 2 2 0 Prohead core protein serine protease Pex24p PF06398.11 CRG86749.1 - 1.6e-95 320.2 0.4 2.6e-95 319.5 0.0 1.5 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin MAJIN PF15077.6 CRG86749.1 - 0.73 9.6 2.2 1.4 8.7 2.2 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein NAD_binding_10 PF13460.6 CRG86750.1 - 4.3e-21 75.6 0.2 6.5e-21 75.0 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG86750.1 - 0.034 13.7 0.2 0.056 13.0 0.2 1.3 1 0 0 1 1 1 0 NmrA-like family Epimerase PF01370.21 CRG86750.1 - 0.037 13.5 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family p450 PF00067.22 CRG86753.1 - 2.4e-55 188.1 0.0 3.1e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MIOX PF05153.15 CRG86754.1 - 6.7e-126 418.9 0.8 8.6e-126 418.6 0.8 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 CRG86754.1 - 0.0092 16.2 0.1 0.76 10.0 0.0 2.6 2 0 0 2 2 2 1 HD domain DUF1796 PF08795.10 CRG86754.1 - 0.038 13.9 0.4 0.064 13.2 0.4 1.4 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) NAAA-beta PF15508.6 CRG86754.1 - 0.05 13.9 0.1 2.3 8.6 0.0 2.6 2 0 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase NOG1_N PF17835.1 CRG86754.1 - 0.37 10.8 3.2 1.3 9.0 0.1 2.7 2 1 0 2 2 2 0 NOG1 N-terminal helical domain Aldo_ket_red PF00248.21 CRG86755.1 - 2e-48 165.1 0.2 2.2e-46 158.4 0.2 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family FAT PF02259.23 CRG86756.1 - 3.2e-130 434.4 0.7 3.2e-130 434.4 0.7 2.2 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 CRG86756.1 - 2.9e-70 236.9 0.1 5.2e-70 236.1 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 CRG86756.1 - 5.5e-68 227.9 6.6 8.3e-62 207.8 1.4 5.0 4 1 1 5 5 5 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 CRG86756.1 - 2.3e-40 137.0 0.1 2.3e-40 137.0 0.1 4.1 5 0 0 5 5 2 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 CRG86756.1 - 3.7e-16 59.3 9.8 0.00063 20.1 0.0 9.1 7 2 1 8 8 7 3 HEAT repeats HEAT_EZ PF13513.6 CRG86756.1 - 2.6e-15 56.5 11.7 0.0074 16.8 0.0 10.5 8 2 2 10 10 9 4 HEAT-like repeat HEAT PF02985.22 CRG86756.1 - 1.1e-14 53.3 18.1 0.02 15.1 0.0 12.5 13 0 0 13 13 13 2 HEAT repeat Cnd1 PF12717.7 CRG86756.1 - 5.2e-08 33.1 1.4 2.8 8.0 0.0 6.5 5 1 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 CRG86756.1 - 6.6e-05 22.6 2.0 5.4 6.5 0.0 5.5 5 0 0 5 5 5 1 CLASP N terminal Sec7_N PF12783.7 CRG86756.1 - 0.0031 17.4 0.4 0.79 9.6 0.0 4.5 3 0 0 3 3 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Spore_III_AB PF09548.10 CRG86756.1 - 0.1 12.7 0.2 2.4 8.2 0.0 3.5 3 1 0 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) TPR_7 PF13176.6 CRG86756.1 - 0.11 12.5 1.0 22 5.4 0.2 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIF4G PF02854.19 CRG86756.1 - 0.19 11.3 2.9 0.47 10.1 0.2 2.9 2 1 0 2 2 2 0 MIF4G domain Dopey_N PF04118.14 CRG86756.1 - 0.88 8.6 6.1 15 4.6 1.1 3.7 3 1 1 4 4 4 0 Dopey, N-terminal TPR_19 PF14559.6 CRG86756.1 - 2.1 8.9 5.9 13 6.4 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat Epimerase PF01370.21 CRG86757.1 - 6.2e-14 52.0 0.0 1.2e-13 51.1 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG86757.1 - 3.9e-10 39.2 0.0 5.2e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG86757.1 - 1.3e-08 34.7 0.0 8e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG86757.1 - 5.5e-08 32.3 0.0 6.2e-06 25.6 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CRG86757.1 - 2.4e-05 24.3 0.0 4.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CRG86757.1 - 0.00011 22.1 0.0 0.0002 21.3 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG86757.1 - 0.0049 16.0 0.0 0.0064 15.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CRG86757.1 - 0.026 14.0 0.0 0.048 13.1 0.0 1.6 1 1 0 1 1 1 0 short chain dehydrogenase NmrA PF05368.13 CRG86757.1 - 0.028 14.0 0.3 0.066 12.8 0.2 1.8 2 1 0 2 2 2 0 NmrA-like family Mob_synth_C PF06463.13 CRG86757.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C Mit_ribos_Mrp51 PF11709.8 CRG86758.1 - 1.6e-105 353.7 0.9 1.8e-105 353.5 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.18 CRG86759.1 - 2.9e-59 198.3 0.9 3.4e-59 198.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal S17 RPAP2_Rtr1 PF04181.13 CRG86760.1 - 9.5e-22 77.1 0.0 1.8e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_1 PF00018.28 CRG86761.1 - 2.7e-10 39.7 0.1 7.1e-10 38.3 0.1 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG86761.1 - 4.7e-08 32.8 0.3 1.3e-07 31.3 0.1 1.9 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CRG86761.1 - 7.5e-08 31.9 0.0 1.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DNA_pol_phi PF04931.13 CRG86761.1 - 0.9 7.6 9.9 1.5 6.8 9.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi F-protein PF00469.20 CRG86761.1 - 1.7 8.2 8.7 0.039 13.5 0.9 2.0 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef DUF1077 PF06417.12 CRG86762.1 - 3.4e-35 120.6 1.3 4.5e-35 120.2 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Adaptin_N PF01602.20 CRG86763.1 - 7.8e-113 377.8 6.0 9.7e-113 377.5 6.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CRG86763.1 - 5.5e-56 189.1 6.9 7.3e-55 185.4 0.6 3.5 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CRG86763.1 - 4e-12 46.4 4.7 0.0041 17.5 0.0 5.0 4 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 CRG86763.1 - 5.3e-08 32.5 3.8 0.41 11.0 0.0 6.0 7 0 0 7 7 7 3 HEAT repeat Atx10homo_assoc PF09759.9 CRG86763.1 - 0.0003 20.7 0.1 7.5 6.6 0.0 4.6 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 CRG86763.1 - 0.006 17.1 2.2 49 4.6 0.0 5.6 6 1 0 6 6 6 0 HEAT-like repeat TIP120 PF08623.10 CRG86763.1 - 0.088 12.6 2.7 4.9 6.9 0.1 3.0 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) DcrB PF08786.11 CRG86763.1 - 0.12 12.5 0.2 0.23 11.5 0.2 1.5 1 0 0 1 1 1 0 DcrB Arm PF00514.23 CRG86763.1 - 0.29 11.2 2.5 3.6 7.8 0.0 3.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Aminotran_5 PF00266.19 CRG86764.1 - 9.3e-08 31.4 0.0 2.7e-06 26.6 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG86764.1 - 0.0087 15.4 0.1 0.016 14.5 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 CRG86764.1 - 0.016 13.8 0.1 0.054 12.0 0.0 1.5 1 1 1 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Fe-S_biosyn PF01521.20 CRG86765.1 - 5.3e-11 42.7 0.0 4.9e-10 39.6 0.0 2.3 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis Paf67 PF10255.9 CRG86766.1 - 1e-159 531.9 0.0 1.2e-159 531.7 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 CRG86766.1 - 0.025 14.7 0.0 0.16 12.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Paf1 PF03985.13 CRG86767.1 - 1.3e-52 179.2 0.1 2e-52 178.6 0.1 1.3 1 0 0 1 1 1 1 Paf1 Glyco_hydro_11 PF00457.17 CRG86768.1 - 3.9e-63 212.3 7.2 4.7e-63 212.0 7.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 LON_substr_bdg PF02190.16 CRG86769.1 - 8.8e-26 91.1 0.0 1.4e-25 90.4 0.0 1.3 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_2 PF13923.6 CRG86769.1 - 2.2e-13 49.8 14.9 1.8e-11 43.7 8.7 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG86769.1 - 6.5e-13 48.5 20.6 3e-08 33.5 3.4 3.5 3 0 0 3 3 3 2 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CRG86769.1 - 2.7e-11 43.2 14.6 3.5e-09 36.4 6.6 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG86769.1 - 5.2e-10 39.0 13.3 2.6e-07 30.4 7.4 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CRG86769.1 - 5.6e-10 39.2 15.5 8.9e-06 25.8 5.8 3.2 2 1 1 3 3 3 2 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 CRG86769.1 - 6.7e-10 39.1 15.6 1.2e-07 31.9 8.3 2.6 2 0 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 CRG86769.1 - 3.4e-09 36.5 13.3 1.3e-05 25.0 7.0 2.5 2 0 0 2 2 2 2 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG86769.1 - 1e-06 28.5 16.5 5.2e-06 26.2 8.0 2.6 2 1 0 2 2 2 2 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 CRG86769.1 - 0.00066 19.9 3.7 0.00066 19.9 3.7 2.3 2 0 0 2 2 2 1 RING-H2 zinc finger domain U-box PF04564.15 CRG86769.1 - 0.00099 19.2 0.0 0.0028 17.8 0.0 1.8 1 0 0 1 1 1 1 U-box domain zf-P11 PF03854.14 CRG86769.1 - 0.0042 16.7 6.5 0.0042 16.7 6.5 2.7 3 0 0 3 3 3 1 P-11 zinc finger zf-RING_10 PF16685.5 CRG86769.1 - 0.0045 17.1 7.9 0.0045 17.1 7.9 2.4 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_4 PF14570.6 CRG86769.1 - 0.0046 16.7 5.8 0.0046 16.7 5.8 3.3 3 0 0 3 3 3 1 RING/Ubox like zinc-binding domain zinc-ribbons_6 PF07191.12 CRG86769.1 - 0.24 11.4 7.9 0.55 10.2 2.3 2.4 2 0 0 2 2 2 0 zinc-ribbons DZR PF12773.7 CRG86769.1 - 1.9 8.6 11.7 3.5 7.7 3.5 2.6 2 0 0 2 2 2 0 Double zinc ribbon zf-ANAPC11 PF12861.7 CRG86769.1 - 3.8 7.6 5.2 0.84 9.7 1.6 1.7 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RICTOR_N PF14664.6 CRG86770.1 - 1.8e-126 422.1 1.4 1.8e-126 422.1 1.4 1.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 CRG86770.1 - 3.7e-37 127.0 0.2 4.5e-35 120.3 0.0 3.5 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 CRG86770.1 - 2.4e-35 120.4 0.1 1.8e-31 108.0 0.1 4.7 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 CRG86770.1 - 1.9e-28 98.5 2.6 1.5e-27 95.6 0.1 3.6 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 CRG86770.1 - 4.2e-15 55.6 9.3 1.2e-14 54.2 9.3 1.8 1 0 0 1 1 1 1 Hr1 repeat Aldedh PF00171.22 CRG86771.1 - 3.6e-116 388.4 1.2 4.4e-116 388.1 1.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Uricase PF01014.18 CRG86772.1 - 3.4e-79 263.5 1.2 1.6e-42 144.9 0.5 2.0 2 0 0 2 2 2 2 Uricase Ribosomal_L13 PF00572.18 CRG86773.1 - 6.1e-42 142.8 0.0 7.8e-42 142.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Ribosomal_S9 PF00380.19 CRG86774.1 - 1.3e-33 116.1 0.3 1.5e-33 115.9 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 AAR2 PF05282.11 CRG86775.1 - 2e-98 330.0 0.0 2.4e-98 329.8 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein Ribosomal_S11 PF00411.19 CRG86776.1 - 1.7e-46 157.1 1.2 2.2e-46 156.8 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 CBM_25 PF03423.13 CRG86776.1 - 0.072 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) PDH PF02153.17 CRG86777.1 - 2.6e-11 43.0 0.0 4.1e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase Actin PF00022.19 CRG86778.1 - 1.8e-30 105.9 0.0 5.4e-18 64.8 0.0 3.1 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 CRG86778.1 - 0.0002 20.3 0.0 0.056 12.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Actin_micro PF17003.5 CRG86778.1 - 0.00071 18.9 0.1 0.024 13.8 0.1 2.2 2 0 0 2 2 2 1 Putative actin-like family FtsA PF14450.6 CRG86778.1 - 0.0069 16.8 0.0 0.037 14.5 0.0 2.2 2 1 0 2 2 2 1 Cell division protein FtsA DUF2114 PF09887.9 CRG86778.1 - 0.14 10.6 0.1 0.2 10.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2114) Arf PF00025.21 CRG86779.1 - 3.2e-73 244.9 0.0 3.8e-73 244.7 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CRG86779.1 - 1.5e-13 51.0 0.0 2e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CRG86779.1 - 2.6e-11 43.3 0.0 3.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 CRG86779.1 - 3.2e-10 39.9 0.0 3.8e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 CRG86779.1 - 2.9e-09 36.6 0.1 4.3e-05 22.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 CRG86779.1 - 6e-08 32.3 0.0 7.9e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 CRG86779.1 - 5.4e-06 26.5 0.0 9.6e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG86779.1 - 0.00058 19.5 0.0 0.046 13.3 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 CRG86779.1 - 0.0089 15.6 0.6 0.039 13.5 0.6 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B DUF3419 PF11899.8 CRG86781.1 - 3.2e-159 530.3 0.0 4.4e-159 529.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_23 PF13489.6 CRG86781.1 - 1.1e-11 44.8 0.0 2.6e-10 40.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG86781.1 - 5.6e-11 43.0 0.0 4.5e-10 40.1 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG86781.1 - 1.1e-10 41.5 0.0 6.7e-10 39.0 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG86781.1 - 1.9e-10 40.5 0.0 4.6e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG86781.1 - 4.3e-10 40.2 0.0 3.1e-09 37.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG86781.1 - 1.7e-09 38.2 0.0 9.8e-09 35.8 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain PCMT PF01135.19 CRG86781.1 - 0.00036 20.3 0.0 0.00071 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 CRG86781.1 - 0.02 14.9 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Rer1 PF03248.13 CRG86782.1 - 5e-81 270.5 4.6 5.9e-81 270.3 4.6 1.0 1 0 0 1 1 1 1 Rer1 family DUF4400 PF14348.6 CRG86782.1 - 0.91 9.0 8.2 0.68 9.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4400) ECH_1 PF00378.20 CRG86783.1 - 1e-75 254.3 0.0 1.7e-75 253.6 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG86783.1 - 5.7e-36 124.7 0.3 6e-35 121.3 0.3 2.2 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase IDO PF01231.18 CRG86783.1 - 0.028 13.2 0.0 0.064 12.0 0.0 1.5 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase RNase_T PF00929.24 CRG86783.1 - 0.036 14.6 0.0 0.6 10.6 0.0 2.3 2 0 0 2 2 2 0 Exonuclease CHORD PF04968.12 CRG86783.1 - 0.056 14.2 0.5 0.056 14.2 0.5 2.0 2 0 0 2 2 2 0 CHORD UPF0180 PF03698.13 CRG86783.1 - 0.11 12.7 0.2 19 5.5 0.0 2.7 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0180) Chlorosome_CsmC PF11098.8 CRG86784.1 - 0.15 12.1 4.0 0.16 12.0 4.0 1.2 1 0 0 1 1 1 0 Chlorosome envelope protein C Lipase_3 PF01764.25 CRG86785.1 - 4.9e-06 26.5 0.0 2.8e-05 24.0 0.0 2.2 3 0 0 3 3 3 1 Lipase (class 3) VPS9 PF02204.18 CRG86786.1 - 3.3e-28 97.9 0.0 6.2e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain ECM11 PF15463.6 CRG86787.1 - 6.3e-43 146.5 0.2 6.3e-43 146.5 0.2 2.4 2 0 0 2 2 2 1 Extracellular mutant protein 11 RNA_pol_I_TF PF04090.12 CRG86788.1 - 5e-12 45.7 0.0 1.2e-10 41.3 0.0 2.2 1 1 0 1 1 1 1 RNA polymerase I specific initiation factor zf-RING_2 PF13639.6 CRG86789.1 - 5.8e-13 48.9 5.7 8.9e-13 48.3 5.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CRG86789.1 - 3e-10 40.2 3.7 5.3e-10 39.4 3.7 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 CRG86789.1 - 6e-09 35.6 5.0 9.6e-09 34.9 5.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CRG86789.1 - 6.8e-08 32.1 2.1 1.2e-07 31.3 2.1 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CRG86789.1 - 1.7e-07 31.0 5.7 2.7e-07 30.4 5.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG86789.1 - 3.7e-05 23.6 4.4 5.5e-05 23.0 4.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CRG86789.1 - 7.9e-05 22.6 2.9 0.00031 20.8 2.9 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CRG86789.1 - 0.00014 21.8 4.4 0.00028 20.8 4.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 CRG86789.1 - 0.00042 19.9 2.8 0.00068 19.2 2.8 1.2 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 CRG86789.1 - 0.00049 19.9 2.8 0.00084 19.1 2.8 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 CRG86789.1 - 0.00055 19.7 3.6 0.0009 19.1 3.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 CRG86789.1 - 0.0035 17.2 2.8 0.08 12.8 1.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 CRG86789.1 - 0.012 15.4 1.4 0.022 14.6 1.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 CRG86789.1 - 0.015 15.5 6.7 0.023 14.8 6.7 1.3 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 CRG86789.1 - 0.052 13.7 4.7 0.093 12.9 4.7 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 CRG86789.1 - 0.11 12.5 4.9 0.082 12.9 3.2 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_4 PF14570.6 CRG86789.1 - 0.11 12.3 4.2 0.18 11.6 4.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 CRG86789.1 - 0.13 12.4 2.5 0.25 11.4 2.5 1.4 1 0 0 1 1 1 0 Zinc-finger Zf_RING PF16744.5 CRG86789.1 - 0.26 11.4 1.8 0.45 10.7 1.8 1.3 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING-like PF08746.11 CRG86789.1 - 0.54 10.6 3.6 0.95 9.8 3.6 1.3 1 0 0 1 1 1 0 RING-like domain PHD PF00628.29 CRG86789.1 - 0.65 9.9 5.1 1 9.3 5.1 1.3 1 0 0 1 1 1 0 PHD-finger Formyl_trans_N PF00551.19 CRG86790.1 - 4e-39 134.2 0.0 4.8e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Acylphosphatase PF00708.18 CRG86790.1 - 0.028 14.8 0.1 4.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Acylphosphatase Fungal_trans_2 PF11951.8 CRG86791.1 - 4.4e-16 58.7 1.5 1.2e-15 57.3 1.6 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86791.1 - 6.9e-08 32.5 11.5 6.9e-08 32.5 11.5 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DEAD PF00270.29 CRG86792.1 - 5.6e-28 97.9 0.0 8.9e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 CRG86792.1 - 3.1e-18 66.3 0.0 1.1e-17 64.6 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 CRG86792.1 - 3.5e-12 46.7 0.0 2.2e-11 44.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG86792.1 - 1.2e-06 28.7 0.0 2.2e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 CRG86792.1 - 0.00016 22.0 0.0 0.00033 21.0 0.0 1.6 1 0 0 1 1 1 1 DNA replication factor CDT1 like PLDc PF00614.22 CRG86792.1 - 0.16 12.2 0.4 0.47 10.7 0.1 1.9 2 0 0 2 2 2 0 Phospholipase D Active site motif DEAD PF00270.29 CRG86793.1 - 5e-49 166.4 0.0 1.1e-47 162.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG86793.1 - 1.4e-30 105.9 0.0 4.9e-30 104.1 0.0 2.0 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG86793.1 - 0.00057 19.9 0.0 0.0019 18.2 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 CRG86793.1 - 0.0046 17.2 0.0 0.0077 16.4 0.0 1.3 1 0 0 1 1 1 1 Helicase C-terminal domain AAA_19 PF13245.6 CRG86793.1 - 0.012 16.0 0.0 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain ERCC3_RAD25_C PF16203.5 CRG86793.1 - 0.018 14.3 0.2 0.027 13.7 0.2 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 CRG86793.1 - 0.057 12.2 2.6 0.73 8.5 0.0 2.6 3 0 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DUF2443 PF10398.9 CRG86793.1 - 0.083 12.9 0.6 0.17 11.9 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) DUF5335 PF17269.2 CRG86793.1 - 0.09 12.6 0.1 0.17 11.7 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5335) zf-C2H2 PF00096.26 CRG86794.1 - 0.13 12.7 0.2 0.3 11.6 0.2 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 CRG86794.1 - 0.15 12.7 0.9 0.31 11.7 0.7 1.7 1 1 0 1 1 1 0 FOXP coiled-coil domain DUF1682 PF07946.14 CRG86794.1 - 4.4 6.4 6.6 5.6 6.1 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) PPR_2 PF13041.6 CRG86795.1 - 5.6e-18 64.9 0.0 2e-14 53.5 0.0 2.7 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 CRG86795.1 - 0.0011 19.0 0.0 2.5 8.2 0.0 2.7 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 CRG86795.1 - 0.015 15.5 0.1 0.75 10.2 0.0 3.4 2 0 0 2 2 2 0 PPR repeat Yip1 PF04893.17 CRG86796.1 - 5.8e-15 55.4 12.7 9.2e-15 54.8 12.7 1.4 1 0 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 CRG86796.1 - 0.012 15.4 5.2 0.02 14.7 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) Ran_BP1 PF00638.18 CRG86797.1 - 9e-21 74.4 0.7 1.4e-20 73.8 0.0 1.7 2 0 0 2 2 2 1 RanBP1 domain Phos_pyr_kin PF08543.12 CRG86798.1 - 9.7e-82 274.0 2.6 1.3e-81 273.6 2.6 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 CRG86798.1 - 1.7e-48 165.2 0.2 2.8e-48 164.5 0.2 1.3 1 0 0 1 1 1 1 TENA/THI-4/PQQC family PfkB PF00294.24 CRG86798.1 - 6.1e-06 25.7 0.4 0.0055 16.0 0.1 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase HK PF02110.15 CRG86798.1 - 6.1e-05 22.5 0.4 0.0051 16.2 0.0 2.2 2 0 0 2 2 2 2 Hydroxyethylthiazole kinase family Carb_kinase PF01256.17 CRG86798.1 - 0.0092 15.5 3.1 0.061 12.8 3.1 2.2 1 1 0 1 1 1 1 Carbohydrate kinase DNA_pol_B PF00136.21 CRG86799.1 - 1.2e-119 400.1 3.2 1.7e-119 399.6 3.2 1.2 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 CRG86799.1 - 3.3e-69 232.3 0.1 7.3e-69 231.2 0.1 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 CRG86799.1 - 3.3e-44 151.4 0.0 6.5e-44 150.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 CRG86799.1 - 8.3e-25 86.7 5.4 8.3e-25 86.7 5.4 3.2 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 CRG86799.1 - 0.0027 16.6 0.0 0.0076 15.2 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral LRR_4 PF12799.7 CRG86800.1 - 0.00091 19.6 10.5 0.34 11.4 0.2 3.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG86800.1 - 0.08 12.7 4.4 8.6 6.2 1.6 2.9 2 1 0 2 2 2 0 Leucine rich repeat Dpy-30 PF05186.13 CRG86800.1 - 0.081 12.6 0.0 0.86 9.4 0.0 2.2 2 0 0 2 2 2 0 Dpy-30 motif Rad9 PF04139.13 CRG86801.1 - 2.5e-41 141.8 0.2 8e-41 140.1 0.2 1.7 1 1 0 1 1 1 1 Rad9 Rad1 PF02144.16 CRG86801.1 - 7.9e-06 25.1 1.1 0.02 14.0 0.3 2.7 1 1 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 RCC1 PF00415.18 CRG86802.1 - 1.6e-36 124.7 15.2 7.7e-08 32.8 0.2 8.0 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CRG86802.1 - 1.9e-17 62.6 29.0 3.7e-05 23.4 0.2 7.4 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Sugar_tr PF00083.24 CRG86803.1 - 4.9e-24 85.0 23.7 1.2e-21 77.2 23.7 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86803.1 - 6.5e-08 31.9 30.9 3.3e-05 23.0 10.3 3.1 1 1 3 4 4 4 2 Major Facilitator Superfamily Pkinase PF00069.25 CRG86804.1 - 6.9e-67 225.6 0.0 9.5e-67 225.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86804.1 - 1.1e-30 106.8 0.0 2.2e-28 99.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CRG86804.1 - 1.3e-06 29.0 0.7 3.4e-06 27.6 0.2 2.0 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 CRG86804.1 - 3.8e-06 26.1 0.0 6e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain RNA_pol_A_bac PF01000.26 CRG86804.1 - 0.089 13.2 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb3/RpoA insert domain Myb_DNA-binding PF00249.31 CRG86805.1 - 2.8e-10 40.2 0.0 8.5e-10 38.7 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain SWIRM PF04433.17 CRG86805.1 - 2.1e-08 34.4 0.0 7.2e-08 32.7 0.0 1.9 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 CRG86805.1 - 4.9e-05 23.1 0.2 0.00013 21.7 0.2 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF5112 PF17139.4 CRG86805.1 - 0.14 11.6 2.5 0.22 11.0 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) Mannitol_dh_C PF08125.13 CRG86806.1 - 3.3e-44 151.2 0.1 5.2e-44 150.6 0.1 1.3 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 CRG86806.1 - 5.1e-19 68.9 0.7 1.5e-18 67.4 0.1 2.0 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain UPF0052 PF01933.18 CRG86806.1 - 0.00078 18.8 1.5 0.014 14.7 0.5 2.1 2 0 0 2 2 2 1 Uncharacterised protein family UPF0052 3HCDH_N PF02737.18 CRG86806.1 - 0.0063 16.4 0.8 0.032 14.1 0.1 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CRG86806.1 - 0.042 13.4 0.3 0.042 13.4 0.3 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RRM_3 PF08777.11 CRG86806.1 - 0.19 11.8 2.3 1.2 9.2 0.0 2.7 3 0 0 3 3 3 0 RNA binding motif SUR7 PF06687.12 CRG86807.1 - 7.7e-27 94.3 8.0 9.2e-27 94.1 8.0 1.0 1 0 0 1 1 1 1 SUR7/PalI family DUF1378 PF07125.11 CRG86807.1 - 0.082 13.1 0.4 12 6.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1378) TMEM208_SND2 PF05620.11 CRG86807.1 - 3.5 7.4 6.7 6 6.6 1.1 2.7 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 Fig1 PF12351.8 CRG86807.1 - 5.9 6.8 15.4 0.79 9.6 10.5 1.8 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Tmemb_18A PF09771.9 CRG86807.1 - 8.1 6.9 7.4 2.9 8.3 1.1 2.6 2 1 1 3 3 3 0 Transmembrane protein 188 Coatomer_WDAD PF04053.14 CRG86808.1 - 2.8e-172 573.8 0.0 1.2e-171 571.7 0.0 1.8 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 CRG86808.1 - 6.5e-39 131.2 8.7 2e-07 31.6 0.0 8.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG86808.1 - 5.9e-09 36.1 0.1 5.3 7.4 0.1 6.5 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG86808.1 - 0.00013 20.8 2.3 0.13 10.9 0.0 3.8 1 1 3 4 4 4 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 CRG86808.1 - 0.0059 16.6 0.0 15 5.7 0.0 4.0 1 1 2 3 3 3 1 Ciliary BBSome complex subunit 2, middle region ETC_C1_NDUFA5 PF04716.14 CRG86809.1 - 1.4e-27 95.2 1.1 2.6e-24 84.8 0.0 2.4 2 0 0 2 2 2 2 ETC complex I subunit conserved region PKD PF00801.20 CRG86809.1 - 0.13 12.2 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 PKD domain Thioredoxin PF00085.20 CRG86810.1 - 2e-46 156.2 0.0 1.9e-24 85.6 0.0 4.4 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 CRG86810.1 - 1.4e-12 47.9 0.0 0.0049 16.8 0.0 5.0 4 1 1 5 5 5 4 Thioredoxin-like domain Thioredoxin_2 PF13098.6 CRG86810.1 - 2e-06 28.2 1.5 0.033 14.6 0.0 3.8 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CRG86810.1 - 0.00011 22.5 0.2 2 8.8 0.0 4.3 3 1 1 4 4 4 1 Thioredoxin-like HyaE PF07449.11 CRG86810.1 - 0.00086 19.3 0.0 0.63 10.0 0.0 3.3 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 CRG86810.1 - 0.0041 17.1 0.2 0.85 9.7 0.0 2.9 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_7 PF13899.6 CRG86810.1 - 0.013 15.6 0.1 0.17 12.1 0.1 2.8 3 0 0 3 3 3 0 Thioredoxin-like TraF PF13728.6 CRG86810.1 - 0.017 15.0 7.1 3.7 7.3 0.0 4.2 4 1 1 5 5 5 0 F plasmid transfer operon protein OST3_OST6 PF04756.13 CRG86810.1 - 0.029 13.7 1.3 4.1 6.7 0.0 2.9 3 0 0 3 3 3 0 OST3 / OST6 family, transporter family Calsequestrin PF01216.17 CRG86810.1 - 0.086 11.9 0.1 0.15 11.1 0.1 1.3 1 0 0 1 1 1 0 Calsequestrin U79_P34 PF03064.16 CRG86810.1 - 7.1 5.9 7.8 19 4.5 7.8 1.7 1 0 0 1 1 1 0 HSV U79 / HCMV P34 AA_permease_2 PF13520.6 CRG86811.1 - 9.9e-67 225.6 44.2 1.5e-66 225.0 44.2 1.2 1 0 0 1 1 1 1 Amino acid permease QCR10 PF09796.9 CRG86811.1 - 3.8e-22 78.1 0.6 3.8e-22 78.1 0.6 3.5 3 0 0 3 3 3 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) AA_permease PF00324.21 CRG86811.1 - 2.4e-18 66.0 34.9 3.7e-18 65.4 34.9 1.2 1 0 0 1 1 1 1 Amino acid permease Zn_clus PF00172.18 CRG86812.1 - 1.3e-06 28.4 5.0 2.3e-06 27.6 5.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0506 PF11703.8 CRG86812.1 - 0.34 11.3 3.4 0.69 10.3 3.4 1.4 1 0 0 1 1 1 0 UPF0506 FliD_N PF02465.18 CRG86812.1 - 6.2 7.6 8.7 0.42 11.3 3.1 1.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TolA_bind_tri PF16331.5 CRG86812.1 - 6.4 6.9 13.1 83 3.4 13.1 2.4 1 1 0 1 1 1 0 TolA binding protein trimerisation Presenilin PF01080.17 CRG86813.1 - 0.11 11.2 5.1 0.11 11.2 5.1 1.1 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 CRG86813.1 - 0.18 10.0 4.2 0.22 9.8 4.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 AF-4 PF05110.13 CRG86813.1 - 0.51 8.4 20.9 0.62 8.1 20.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4551 PF15087.6 CRG86813.1 - 0.87 8.3 9.9 1 8.1 9.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) FAM76 PF16046.5 CRG86813.1 - 3.1 7.1 8.2 3.8 6.8 8.2 1.1 1 0 0 1 1 1 0 FAM76 protein Hid1 PF12722.7 CRG86813.1 - 4.7 5.2 8.2 5.2 5.1 8.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 CRG86813.1 - 4.7 5.8 8.0 5.6 5.6 8.0 1.1 1 0 0 1 1 1 0 Raftlin Dicty_REP PF05086.12 CRG86813.1 - 6.4 4.6 10.2 7.8 4.3 10.2 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hydin_ADK PF17213.3 CRG86813.1 - 6.7 6.9 10.4 9.8 6.4 10.4 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain NST1 PF13945.6 CRG86813.1 - 8.6 6.4 10.2 11 6.1 10.2 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator zf-H2C2_2 PF13465.6 CRG86814.1 - 2.3e-07 30.9 7.6 1.6e-05 25.1 1.4 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-Di19 PF05605.12 CRG86814.1 - 0.00023 21.4 4.7 0.0004 20.6 4.7 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 CRG86814.1 - 0.00025 21.6 15.0 0.018 15.9 5.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG86814.1 - 0.002 18.4 4.8 0.08 13.3 1.2 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 CRG86814.1 - 0.035 14.6 14.5 0.12 12.9 7.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-met PF12874.7 CRG86814.1 - 0.77 10.2 5.0 4.3 7.9 0.8 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DHO_dh PF01180.21 CRG86818.1 - 3.1e-63 213.7 0.0 4e-63 213.4 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 CRG86818.1 - 0.00047 19.7 0.7 0.00076 19.0 0.7 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 CRG86818.1 - 0.035 13.1 0.4 1.9 7.4 0.9 2.5 2 1 0 2 2 2 0 FMN-dependent dehydrogenase TIM PF00121.18 CRG86819.1 - 6.7e-41 140.3 0.0 8.5e-41 139.9 0.0 1.2 1 0 0 1 1 1 1 Triosephosphate isomerase LacAB_rpiB PF02502.18 CRG86820.1 - 2.3e-42 144.3 0.0 2.6e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase DUF2620 PF10941.8 CRG86820.1 - 0.046 13.9 0.0 0.062 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2620 Gly_rich_SFCGS PF14272.6 CRG86820.1 - 0.067 13.2 0.0 0.099 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycine-rich SFCGS HCMV_UL124 PF17609.2 CRG86820.1 - 0.11 12.7 0.0 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function U-box PF04564.15 CRG86821.1 - 1e-20 73.7 0.0 2e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 U-box domain ACBP PF00887.19 CRG86821.1 - 5e-10 39.5 2.6 9.2e-10 38.6 0.2 2.6 3 0 0 3 3 3 1 Acyl CoA binding protein TPR_2 PF07719.17 CRG86821.1 - 6.8e-06 25.8 1.4 0.068 13.3 0.3 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG86821.1 - 5.3e-05 22.8 4.1 0.006 16.4 0.4 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CRG86821.1 - 0.00021 21.7 1.6 0.036 14.6 0.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 CRG86821.1 - 0.00034 21.2 3.6 0.18 12.7 0.0 3.7 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 CRG86821.1 - 0.00063 20.3 0.1 0.00063 20.3 0.1 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG86821.1 - 0.00072 19.2 0.4 0.0035 17.0 0.0 2.4 2 0 0 2 2 2 1 TPR repeat CHIP_TPR_N PF18391.1 CRG86821.1 - 0.0011 19.7 2.7 0.0024 18.6 2.7 1.5 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_12 PF13424.6 CRG86821.1 - 0.0085 16.4 4.4 0.09 13.1 1.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG86821.1 - 0.01 16.2 0.1 0.19 12.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG86821.1 - 0.031 14.5 0.7 1.2 9.4 0.5 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 zf-Nse PF11789.8 CRG86821.1 - 0.065 13.1 0.0 0.16 11.8 0.0 1.6 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Tyr-DNA_phospho PF06087.12 CRG86822.1 - 4e-164 546.5 0.0 4.6e-164 546.3 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 CRG86822.1 - 0.00015 21.6 0.0 0.46 10.4 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain NACHT PF05729.12 CRG86823.1 - 7e-10 39.1 0.1 2e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG86823.1 - 1.1e-07 32.4 0.0 5.3e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CRG86823.1 - 4e-07 30.5 0.0 3e-06 27.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Ank_2 PF12796.7 CRG86823.1 - 1.3e-06 28.9 0.0 6.6e-06 26.6 0.0 2.2 2 0 0 2 2 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG86823.1 - 3.4e-06 27.2 0.0 8.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Goodbye PF17109.5 CRG86823.1 - 2.8e-05 24.6 0.0 7.7e-05 23.1 0.0 1.9 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain Ank PF00023.30 CRG86823.1 - 5.1e-05 23.5 1.0 0.00064 20.1 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 CRG86823.1 - 5.1e-05 23.7 0.0 1.6 9.4 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG86823.1 - 0.00011 22.4 0.7 0.008 16.6 0.1 3.6 4 0 0 4 4 2 1 Ankyrin repeat AAA_22 PF13401.6 CRG86823.1 - 0.00012 22.4 0.0 0.0004 20.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 CRG86823.1 - 0.00013 22.0 0.1 0.00031 20.8 0.1 1.6 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 CRG86823.1 - 0.0014 18.7 0.0 2.6 8.2 0.0 2.8 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_14 PF13173.6 CRG86823.1 - 0.0017 18.4 0.1 0.35 10.9 0.0 2.6 1 1 1 2 2 2 1 AAA domain NB-ARC PF00931.22 CRG86823.1 - 0.0042 16.3 0.2 0.0097 15.1 0.2 1.5 1 0 0 1 1 1 1 NB-ARC domain RNA_helicase PF00910.22 CRG86823.1 - 0.0072 16.7 0.0 0.023 15.1 0.0 1.9 1 1 0 1 1 1 1 RNA helicase Parvo_NS1 PF01057.17 CRG86823.1 - 0.05 12.7 0.5 0.42 9.7 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 CRG86823.1 - 0.13 11.8 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CRG86823.1 - 0.14 12.7 0.2 0.82 10.2 0.0 2.2 2 0 0 2 2 2 0 ABC transporter DIE2_ALG10 PF04922.12 CRG86824.1 - 1.6e-122 409.6 11.4 2.3e-122 409.1 11.4 1.3 1 0 0 1 1 1 1 DIE2/ALG10 family DUF2207 PF09972.9 CRG86824.1 - 0.051 12.3 4.9 3.5 6.3 2.9 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) MRVI1 PF05781.12 CRG86824.1 - 0.057 12.1 0.5 0.089 11.5 0.5 1.1 1 0 0 1 1 1 0 MRVI1 protein Ribosomal_S25 PF03297.15 CRG86824.1 - 0.15 12.3 6.2 0.31 11.3 6.2 1.4 1 0 0 1 1 1 0 S25 ribosomal protein GET2 PF08690.10 CRG86824.1 - 0.54 9.9 4.9 0.058 13.1 0.6 1.6 2 0 0 2 2 2 0 GET complex subunit GET2 TMEM208_SND2 PF05620.11 CRG86824.1 - 1.3 8.8 8.9 0.27 11.0 3.8 2.7 2 1 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 HAT_KAT11 PF08214.11 CRG86824.1 - 1.9 7.7 6.1 2.8 7.1 6.1 1.1 1 0 0 1 1 1 0 Histone acetylation protein CPSF100_C PF13299.6 CRG86824.1 - 2.1 8.5 6.1 3.3 7.9 6.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal XAP5 PF04921.14 CRG86824.1 - 4.2 7.1 7.8 7.4 6.3 7.8 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator Sld5 PF05916.11 CRG86825.1 - 1.7e-31 108.9 0.0 6.5e-31 107.0 0.0 1.8 1 1 0 1 1 1 1 GINS complex protein CUE PF02845.16 CRG86826.1 - 9.6e-11 41.2 0.0 1.9e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 CUE domain G2BR PF18442.1 CRG86826.1 - 0.012 15.2 9.7 0.03 14.0 9.7 1.7 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) SMC_N PF02463.19 CRG86827.1 - 1.3e-70 237.2 0.0 6.6e-70 235.0 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CRG86827.1 - 3.8e-19 69.1 0.5 2e-18 66.8 0.2 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 CRG86827.1 - 1.7e-10 41.8 10.7 1.7e-10 41.8 10.7 6.9 2 2 4 6 6 6 1 AAA domain AAA_21 PF13304.6 CRG86827.1 - 5.9e-10 39.4 10.7 0.00022 21.2 0.1 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG86827.1 - 0.00015 21.5 0.1 0.00033 20.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain HSBP1 PF06825.12 CRG86827.1 - 0.026 14.4 12.0 0.32 10.9 0.5 4.5 4 0 0 4 4 4 0 Heat shock factor binding protein 1 ABC_tran PF00005.27 CRG86827.1 - 0.059 13.9 0.0 0.059 13.9 0.0 5.4 4 2 0 4 4 4 0 ABC transporter NOT2_3_5 PF04153.18 CRG86828.1 - 9.1e-28 97.0 1.4 2.8e-27 95.4 0.0 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family CCDC53 PF10152.9 CRG86828.1 - 2.6 8.4 7.6 22 5.4 3.4 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex ORC6 PF05460.13 CRG86828.1 - 3.4 6.8 12.3 0.41 9.9 6.3 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) MRP-L47 PF06984.13 CRG86829.1 - 3.3e-20 72.0 0.0 6.2e-20 71.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GDI PF00996.18 CRG86830.1 - 1.7e-193 643.0 0.1 2e-193 642.8 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 CRG86830.1 - 0.0078 16.4 0.0 0.021 15.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG86830.1 - 0.0089 16.6 0.3 0.22 12.1 0.2 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 4HBT PF03061.22 CRG86831.1 - 4.1e-11 43.1 0.0 5.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 CRG86831.1 - 0.00069 20.0 0.0 0.00091 19.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF4442 PF14539.6 CRG86831.1 - 0.0019 18.3 0.0 0.0023 18.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) Dynamin_N PF00350.23 CRG86832.1 - 4.4e-09 36.6 0.0 1.7e-08 34.7 0.0 2.0 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CRG86832.1 - 5.5e-05 23.2 0.0 0.038 14.1 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG86832.1 - 0.00078 19.4 1.0 0.0058 16.5 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 CRG86832.1 - 0.004 16.5 0.0 0.0082 15.5 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 CRG86832.1 - 0.0069 15.5 0.0 0.017 14.2 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 CRG86832.1 - 0.009 16.5 0.0 0.034 14.7 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 CRG86832.1 - 0.013 15.9 0.0 0.035 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain DLIC PF05783.11 CRG86832.1 - 0.038 12.8 0.1 0.96 8.2 0.0 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) DUF87 PF01935.17 CRG86832.1 - 0.094 12.8 3.2 0.17 12.0 0.1 2.7 2 1 0 2 2 2 0 Helicase HerA, central domain AAA_29 PF13555.6 CRG86832.1 - 0.15 11.9 0.1 0.46 10.3 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain TPR_12 PF13424.6 CRG86833.1 - 0.00041 20.6 0.1 0.084 13.2 0.0 2.9 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG86833.1 - 0.0031 17.3 0.5 0.063 13.2 0.0 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 CRG86833.1 - 0.0078 16.3 0.2 0.024 14.8 0.2 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG86833.1 - 0.071 13.3 0.0 40 4.7 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ORC4_C PF14629.6 CRG86834.1 - 1.7e-44 151.8 0.0 2.5e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 CRG86834.1 - 8.9e-16 58.7 0.1 7.7e-15 55.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 CRG86834.1 - 3.8e-05 23.0 0.0 6.9e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA PF00004.29 CRG86834.1 - 6.1e-05 23.4 0.0 0.00025 21.5 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG86834.1 - 8.6e-05 22.8 0.0 0.00022 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CRG86834.1 - 0.0003 20.7 0.1 0.001 19.0 0.1 1.9 1 1 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.14 CRG86834.1 - 0.00034 20.0 0.0 0.00052 19.4 0.0 1.2 1 0 0 1 1 1 1 KAP family P-loop domain AAA_29 PF13555.6 CRG86834.1 - 0.0033 17.1 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATPase_2 PF01637.18 CRG86834.1 - 0.0062 16.5 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea PIF1 PF05970.14 CRG86834.1 - 0.007 15.6 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 PIF1-like helicase Mg_chelatase PF01078.21 CRG86834.1 - 0.0072 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI SMC_N PF02463.19 CRG86834.1 - 0.033 13.6 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_19 PF13245.6 CRG86834.1 - 0.037 14.4 0.0 0.094 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CRG86834.1 - 0.055 13.0 0.0 0.097 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Gtr1_RagA PF04670.12 CRG86834.1 - 0.14 11.4 0.3 0.26 10.6 0.3 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Glyco_hydro_106 PF17132.4 CRG86835.1 - 1.9e-26 92.6 3.8 2.6e-25 88.9 1.1 2.4 3 0 0 3 3 3 2 alpha-L-rhamnosidase RGS PF00615.19 CRG86836.1 - 2.2e-32 111.8 0.0 5.7e-32 110.5 0.0 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 CRG86836.1 - 5.8e-27 93.6 0.2 3.4e-20 71.9 0.0 3.4 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CDC73_C PF05179.14 CRG86837.1 - 1.3e-51 174.4 0.0 2.2e-51 173.7 0.0 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal WD40 PF00400.32 CRG86838.1 - 1.1e-10 41.9 13.5 0.0059 17.4 0.6 5.6 4 0 0 4 4 4 3 WD domain, G-beta repeat SET PF00856.28 CRG86838.1 - 1.6e-06 28.6 0.5 1.8e-05 25.2 0.5 2.6 1 1 0 1 1 1 1 SET domain PHD PF00628.29 CRG86838.1 - 4.4e-05 23.3 10.8 9.6e-05 22.2 10.8 1.6 1 0 0 1 1 1 1 PHD-finger ANAPC4_WD40 PF12894.7 CRG86838.1 - 0.0056 17.0 0.2 0.51 10.7 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG86838.1 - 0.1 11.5 0.2 3.7 6.4 0.0 2.6 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Prok-RING_1 PF14446.6 CRG86838.1 - 6 6.9 9.2 5.7 7.0 7.5 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Glycos_transf_4 PF00953.21 CRG86839.1 - 1.9e-31 109.2 11.5 1.9e-31 109.2 11.5 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 4 FMO-like PF00743.19 CRG86839.1 - 8.8e-15 54.1 0.0 2e-11 43.1 0.0 2.3 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG86839.1 - 5.5e-12 45.7 0.0 1.3e-11 44.6 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG86839.1 - 1.3e-06 27.9 0.0 3.6e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG86839.1 - 3.1e-05 23.7 0.0 0.0097 15.5 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG86839.1 - 0.004 17.2 0.3 0.034 14.1 0.0 2.6 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG86839.1 - 0.017 14.3 0.3 0.15 11.3 0.2 2.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CRG86839.1 - 0.019 14.4 0.0 1.9 7.8 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 CRG86839.1 - 0.034 13.2 0.1 2.7 7.0 0.2 2.2 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 CRG86839.1 - 0.036 13.3 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 CRG86839.1 - 0.2 10.9 0.2 0.64 9.3 0.1 1.9 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CRG86839.1 - 0.29 10.3 0.2 0.43 9.8 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 CRG86839.1 - 0.55 9.3 1.4 7.3 5.6 0.4 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Glyco_hydro_79C PF16862.5 CRG86840.1 - 6.2e-27 94.5 0.3 6.2e-27 94.5 0.3 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Glyco_hydro_79n PF03662.14 CRG86840.1 - 0.023 13.6 0.3 1 8.2 0.2 2.5 2 1 0 2 2 2 0 Glycosyl hydrolase family 79, N-terminal domain CBM_6 PF03422.15 CRG86841.1 - 0.00036 20.8 0.1 0.0012 19.2 0.1 1.8 1 0 0 1 1 1 1 Carbohydrate binding module (family 6) Trehalase PF01204.18 CRG86841.1 - 0.013 14.3 0.0 0.023 13.5 0.0 1.3 1 0 0 1 1 1 0 Trehalase Glyco_hydro_63 PF03200.16 CRG86841.1 - 0.056 12.2 0.1 0.67 8.6 0.1 2.0 1 1 0 1 1 1 0 Glycosyl hydrolase family 63 C-terminal domain ADH_zinc_N PF00107.26 CRG86842.1 - 6e-07 29.5 0.0 1.3e-06 28.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG86842.1 - 2.5e-05 24.1 0.0 4.8e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CRG86842.1 - 0.15 13.1 0.0 0.29 12.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AA_permease_2 PF13520.6 CRG86843.1 - 7.3e-81 272.2 29.5 8.9e-81 271.9 29.5 1.1 1 0 0 1 1 1 1 Amino acid permease PhoLip_ATPase_C PF16212.5 CRG86843.1 - 1.4 8.6 17.9 1.1 8.9 0.1 3.0 2 1 1 3 3 3 0 Phospholipid-translocating P-type ATPase C-terminal P5CR_dimer PF14748.6 CRG86844.1 - 1.3e-14 54.3 0.8 1.3e-14 54.3 0.8 2.3 3 0 0 3 3 3 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CRG86844.1 - 2.7e-09 37.5 1.9 1.3e-05 25.7 0.0 3.1 3 0 0 3 3 3 2 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CRG86844.1 - 0.00021 20.7 0.6 0.1 11.9 0.2 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 CRG86844.1 - 0.14 12.1 0.1 1.4 8.9 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Ank_2 PF12796.7 CRG86846.1 - 1.8e-30 105.3 3.0 1.5e-07 31.9 0.1 6.5 3 3 4 7 7 7 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG86846.1 - 8.5e-28 96.1 6.4 4.5e-06 26.8 0.3 8.5 8 1 1 9 9 9 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG86846.1 - 1.1e-26 92.9 12.4 2.6e-05 24.6 0.0 8.6 6 2 3 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG86846.1 - 4.9e-23 78.7 4.6 0.0096 16.4 0.1 9.5 12 0 0 12 12 12 4 Ankyrin repeat Ank PF00023.30 CRG86846.1 - 2.8e-18 65.5 8.9 0.24 11.9 0.4 9.5 10 0 0 10 10 10 6 Ankyrin repeat GATase_7 PF13537.6 CRG86846.1 - 0.051 13.5 0.0 0.88 9.5 0.0 2.4 2 0 0 2 2 2 0 Glutamine amidotransferase domain GMP_synt_C PF00958.22 CRG86847.1 - 9.8e-39 131.3 0.0 2.7e-38 129.9 0.0 1.8 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 CRG86847.1 - 2e-38 132.1 0.0 4e-38 131.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 CRG86847.1 - 1.2e-09 37.7 0.0 1.1e-05 24.7 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 CRG86847.1 - 2.1e-06 27.7 0.0 4.5e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 CRG86847.1 - 4.9e-05 22.3 0.0 0.00022 20.2 0.0 1.8 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 CRG86847.1 - 0.00086 18.9 0.0 0.038 13.5 0.0 2.2 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 CRG86847.1 - 0.0043 16.4 0.0 0.0063 15.8 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase ThiI PF02568.14 CRG86847.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 CRG86847.1 - 0.016 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ATP_bind_3 PF01171.20 CRG86847.1 - 0.074 12.8 0.0 0.14 11.9 0.0 1.6 1 1 0 1 1 1 0 PP-loop family Bac_rhamnosid6H PF17389.2 CRG86848.1 - 7.2e-18 64.9 0.4 1.1e-17 64.4 0.4 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_36 PF17167.4 CRG86848.1 - 8.4e-07 28.0 0.0 1.3e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Sugar_tr PF00083.24 CRG86849.1 - 6.1e-67 226.4 28.8 7.2e-67 226.2 28.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86849.1 - 2.9e-17 62.6 34.8 2.6e-08 33.2 17.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Tail_VII PF17091.5 CRG86849.1 - 0.11 12.4 0.2 0.11 12.4 0.2 3.3 3 0 0 3 3 3 0 Inovirus G7P protein Tetraspanin PF00335.20 CRG86849.1 - 1.7 8.3 6.5 3.9 7.1 5.6 2.0 1 1 0 1 1 1 0 Tetraspanin family MFS_1 PF07690.16 CRG86850.1 - 1e-07 31.2 28.5 1e-07 31.2 28.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG86850.1 - 3.2e-06 26.9 4.0 3.2e-06 26.9 4.0 2.2 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Amidohydro_2 PF04909.14 CRG86851.1 - 8e-07 29.1 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 CRG86851.1 - 0.0002 20.8 0.2 0.0021 17.5 0.2 2.7 1 1 0 1 1 1 1 Amidohydrolase family NCKAP5 PF15246.6 CRG86851.1 - 0.049 13.2 0.0 0.064 12.9 0.0 1.1 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Pyridoxal_deC PF00282.19 CRG86851.1 - 0.085 11.6 0.0 0.12 11.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Aconitase PF00330.20 CRG86852.1 - 7e-161 536.3 0.0 8.6e-161 536.0 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CRG86852.1 - 1.2e-41 142.1 0.0 2.6e-41 141.0 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain Alpha-amylase PF00128.24 CRG86853.1 - 6.7e-18 65.3 0.1 1.4e-17 64.2 0.1 1.5 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 CRG86853.1 - 2e-14 53.9 0.0 3.4e-14 53.1 0.0 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CRG86853.1 - 0.00031 20.3 0.0 0.00069 19.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CRG86853.1 - 0.042 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DUF373 PF04123.13 CRG86853.1 - 0.74 9.2 5.5 1.6 8.1 5.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Pribosyltran PF00156.27 CRG86854.1 - 6.6e-13 48.5 0.3 1.1e-12 47.8 0.3 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MMACHC PF16690.5 CRG86854.1 - 0.25 11.0 0.0 0.34 10.5 0.0 1.2 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type C family MTHFR PF02219.17 CRG86855.1 - 8.9e-116 386.2 0.0 1.2e-115 385.8 0.0 1.2 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF2418 PF10332.9 CRG86857.1 - 1.8e-36 124.6 0.3 1.8e-36 124.6 0.3 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF2418) ATP-synt_F PF01990.17 CRG86858.1 - 7.2e-33 112.8 0.1 8.3e-33 112.6 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit E1_DerP2_DerF2 PF02221.15 CRG86859.1 - 2.2e-27 96.1 0.2 2.9e-27 95.7 0.2 1.1 1 0 0 1 1 1 1 ML domain Big_9 PF17963.1 CRG86859.1 - 0.0039 17.9 0.0 0.0064 17.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial Ig domain KH_8 PF17903.1 CRG86860.1 - 6.4e-32 109.5 0.0 1.4e-31 108.4 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain Methyltransf_11 PF08241.12 CRG86860.1 - 0.0039 17.8 0.0 0.029 15.0 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain KH_1 PF00013.29 CRG86860.1 - 0.037 13.9 0.0 0.081 12.8 0.0 1.6 1 0 0 1 1 1 0 KH domain Nitroreductase PF00881.24 CRG86861.1 - 1.7e-13 50.9 0.0 2.2e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family BAR_2 PF10455.9 CRG86863.1 - 8.8e-62 208.8 0.7 1.3e-61 208.3 0.7 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 CRG86863.1 - 1.1e-21 77.6 4.5 2.1e-20 73.4 4.5 2.1 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 CRG86863.1 - 0.015 15.0 0.8 0.07 12.8 0.2 2.1 2 0 0 2 2 2 0 BAR domain of APPL family Arv1 PF04161.13 CRG86864.1 - 2.2e-50 171.8 0.0 3.2e-49 167.9 0.0 2.3 1 1 0 1 1 1 1 Arv1-like family APH PF01636.23 CRG86864.1 - 6.7e-09 36.0 0.2 9.3e-08 32.3 0.2 2.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG86864.1 - 1e-05 25.2 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fungal_trans_2 PF11951.8 CRG86865.1 - 1.3e-16 60.4 1.9 7.8e-15 54.6 0.8 2.7 3 0 0 3 3 3 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86865.1 - 3e-07 30.4 12.2 5.8e-07 29.5 12.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ANAPC5 PF12862.7 CRG86865.1 - 0.065 13.3 0.2 0.14 12.3 0.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 Methyltransf_8 PF05148.15 CRG86866.1 - 6.1e-57 193.0 0.1 5.7e-54 183.3 0.0 3.0 3 1 0 3 3 3 2 Hypothetical methyltransferase Methyltransf_11 PF08241.12 CRG86866.1 - 1.7e-06 28.6 0.0 9.2e-06 26.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG86866.1 - 7.7e-05 23.3 0.0 0.0047 17.6 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 CRG86866.1 - 0.074 13.0 0.0 0.074 13.0 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase domain CAP_N PF01213.19 CRG86866.1 - 2.2 7.7 14.9 0.11 12.0 7.9 2.4 2 1 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Proteasome PF00227.26 CRG86867.1 - 8.6e-56 188.4 0.2 1.1e-55 188.1 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CRG86867.1 - 1.7e-12 46.7 0.0 3.6e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature GCP_N_terminal PF17681.1 CRG86868.1 - 6.9e-68 229.5 0.0 1.1e-67 228.9 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CRG86868.1 - 5.4e-63 213.3 2.6 8.7e-63 212.6 2.6 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Beta-lactamase PF00144.24 CRG86869.1 - 5.7e-41 140.8 0.0 8.3e-41 140.3 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase FMO-like PF00743.19 CRG86870.1 - 1.2e-16 60.2 0.8 3.8e-13 48.7 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG86870.1 - 1.8e-11 43.8 0.0 3.2e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG86870.1 - 6.8e-10 38.6 0.0 7.9e-09 35.1 0.0 2.2 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG86870.1 - 2.9e-09 36.6 0.0 5.8e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG86870.1 - 4.2e-08 33.3 0.2 7.9e-07 29.2 0.1 2.8 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG86870.1 - 0.0012 18.6 0.7 0.12 12.0 0.0 2.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG86870.1 - 0.0016 18.9 0.2 3.3 8.3 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG86870.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 CRG86870.1 - 0.015 15.3 4.3 10 6.1 0.0 4.0 4 0 0 4 4 4 0 FAD-NAD(P)-binding HI0933_like PF03486.14 CRG86870.1 - 0.022 13.4 1.3 0.059 12.1 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein Lycopene_cycl PF05834.12 CRG86870.1 - 0.086 11.9 0.1 0.15 11.0 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein AMP-binding PF00501.28 CRG86872.1 - 6.9e-60 202.8 0.0 1.8e-59 201.5 0.0 1.6 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG86872.1 - 0.0035 18.3 0.0 0.01 16.8 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain GHL13 PF14883.6 CRG86872.1 - 0.049 12.7 0.0 0.6 9.1 0.0 2.2 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase family 13 Thiolase_N PF00108.23 CRG86873.1 - 1.3e-68 231.1 0.1 2.7e-68 230.1 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG86873.1 - 3.4e-43 146.2 0.2 7.4e-43 145.1 0.2 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 CRG86873.1 - 0.0026 17.9 0.0 0.0085 16.2 0.0 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CRG86873.1 - 0.0027 17.5 0.1 0.27 11.1 0.1 2.5 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 CRG86873.1 - 0.003 17.2 1.1 0.016 14.8 1.3 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SasG_E PF17041.5 CRG86873.1 - 0.063 13.3 0.5 0.18 11.8 0.5 1.8 1 0 0 1 1 1 0 E domain DUF1996 PF09362.10 CRG86874.1 - 1.9e-89 299.7 0.9 2.9e-89 299.1 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 CRG86874.1 - 1.7e-19 69.8 9.3 6.4e-19 67.9 9.3 2.1 1 0 0 1 1 1 1 WSC domain GST_N_3 PF13417.6 CRG86875.1 - 1.5e-07 31.7 0.1 4.4e-07 30.2 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG86875.1 - 9.2e-07 29.1 0.0 0.00012 22.4 0.0 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG86875.1 - 1.2e-06 28.6 0.0 2.6e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG86875.1 - 3.7e-05 23.9 0.0 0.0001 22.5 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG86875.1 - 5.1e-05 23.5 0.0 0.00024 21.4 0.0 2.1 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG86875.1 - 0.00026 20.9 0.0 0.00049 20.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain adh_short PF00106.25 CRG86876.1 - 1.4e-09 37.7 0.0 2.5e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86876.1 - 4.5e-09 36.5 0.0 9.6e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG86876.1 - 1.7e-05 24.5 0.0 3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glu_dehyd_C PF16912.5 CRG86876.1 - 0.0044 16.5 0.0 0.015 14.7 0.0 1.9 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ATG22 PF11700.8 CRG86877.1 - 7.1e-132 440.4 27.9 8.9e-132 440.1 27.9 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Dala_Dala_lig_C PF07478.13 CRG86877.1 - 1.3e-11 44.5 0.0 2.3e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus MFS_1 PF07690.16 CRG86877.1 - 1.8e-11 43.6 27.4 1.8e-06 27.2 11.8 3.2 2 1 1 3 3 3 2 Major Facilitator Superfamily CPSase_L_D2 PF02786.17 CRG86877.1 - 0.0036 16.8 0.0 0.0075 15.8 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 CRG86877.1 - 0.016 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp PF02222.22 CRG86877.1 - 0.028 14.0 0.0 0.079 12.5 0.0 1.7 2 0 0 2 2 2 0 ATP-grasp domain ATP-grasp_4 PF13535.6 CRG86877.1 - 0.041 13.5 0.0 0.11 12.0 0.0 1.8 1 1 0 1 1 1 0 ATP-grasp domain Gram_pos_anchor PF00746.21 CRG86877.1 - 0.046 13.7 0.3 0.29 11.1 0.0 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif GARS_A PF01071.19 CRG86877.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Pox_A14 PF05767.12 CRG86877.1 - 8.5 6.6 9.1 20 5.4 0.3 3.7 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 zf_PR_Knuckle PF18445.1 CRG86878.1 - 1 9.3 4.8 3.7 7.4 4.8 2.0 1 0 0 1 1 1 0 PR zinc knuckle motif Exonuc_VII_L PF02601.15 CRG86878.1 - 3.7 7.0 36.1 0.1 12.1 18.9 3.2 3 0 0 3 3 3 0 Exonuclease VII, large subunit CIA30 PF08547.12 CRG86879.1 - 1.3e-05 25.2 0.0 1.7e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) NAD_binding_2 PF03446.15 CRG86880.1 - 4.3e-30 105.0 0.0 6.2e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CRG86880.1 - 2.6e-10 40.7 0.0 6.3e-10 39.5 0.0 1.6 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 CRG86880.1 - 4.9e-09 36.4 0.0 8e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_11 PF14833.6 CRG86880.1 - 2.5e-06 27.8 0.1 9.8e-06 25.8 0.1 1.9 1 1 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase GFO_IDH_MocA PF01408.22 CRG86880.1 - 0.044 14.6 0.0 0.09 13.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold UDPG_MGDP_dh_N PF03721.14 CRG86880.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 CRG86880.1 - 0.16 12.2 0.0 0.27 11.5 0.0 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAT PF04768.13 CRG86881.1 - 5.2e-49 166.2 0.0 1.5e-48 164.7 0.0 1.7 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase F-box-like PF12937.7 CRG86882.1 - 0.022 14.6 0.7 0.047 13.6 0.7 1.6 1 0 0 1 1 1 0 F-box-like Fungal_trans_2 PF11951.8 CRG86883.1 - 1.2e-07 30.9 0.0 2e-07 30.2 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 CRG86884.1 - 4.6e-52 176.9 1.5 5.7e-52 176.6 1.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86884.1 - 7.9e-41 139.7 1.2 9.6e-41 139.4 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86884.1 - 6.5e-09 36.0 0.2 9.3e-09 35.4 0.2 1.2 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CRG86884.1 - 0.0013 18.1 1.2 0.0022 17.3 1.2 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AdoHcyase_NAD PF00670.21 CRG86884.1 - 0.0013 18.8 1.2 0.0025 17.9 1.2 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Epimerase PF01370.21 CRG86884.1 - 0.0045 16.5 0.1 0.019 14.5 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CRG86884.1 - 0.026 14.4 1.1 0.045 13.6 1.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PGA_cap PF09587.10 CRG86884.1 - 0.047 13.1 0.1 0.063 12.7 0.1 1.2 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap ADH_zinc_N PF00107.26 CRG86885.1 - 0.096 12.7 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Zinc-binding dehydrogenase adh_short PF00106.25 CRG86886.1 - 1.4e-29 103.0 1.1 1.7e-29 102.7 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86886.1 - 6.6e-23 81.5 0.9 1.1e-22 80.7 0.7 1.4 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86886.1 - 7.7e-08 32.4 0.2 1.1e-07 32.0 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG86886.1 - 0.0022 17.5 0.2 1.5 8.2 0.3 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 CRG86886.1 - 0.003 17.5 2.2 0.0047 16.8 2.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CRG86886.1 - 0.0054 16.8 0.6 0.01 15.9 0.6 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 CRG86886.1 - 0.015 14.5 0.3 0.02 14.0 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 CRG86886.1 - 0.083 12.2 0.7 0.19 11.1 0.2 1.8 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ank_2 PF12796.7 CRG86887.1 - 5.5e-28 97.4 0.0 6e-09 36.4 0.0 4.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG86887.1 - 7.2e-21 74.3 0.0 1.2e-06 28.9 0.0 5.8 2 1 4 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 CRG86887.1 - 2e-20 72.3 0.0 0.0016 18.8 0.0 6.8 6 0 0 6 6 6 3 Ankyrin repeat Ank_5 PF13857.6 CRG86887.1 - 5.7e-20 71.1 0.1 7.4e-08 32.5 0.0 4.6 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG86887.1 - 3e-18 64.0 0.0 0.0001 22.4 0.0 6.1 6 0 0 6 6 6 3 Ankyrin repeat AAA_16 PF13191.6 CRG86887.1 - 4.3e-09 37.0 0.3 6.3e-08 33.2 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain PNP_UDP_1 PF01048.20 CRG86887.1 - 1.1e-08 34.7 0.0 2.8e-08 33.3 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily KAP_NTPase PF07693.14 CRG86887.1 - 0.00087 18.6 0.0 0.037 13.2 0.1 2.3 1 1 1 2 2 2 1 KAP family P-loop domain NACHT PF05729.12 CRG86887.1 - 0.0018 18.2 0.0 0.0037 17.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CRG86887.1 - 0.0054 17.0 0.0 0.02 15.2 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CRG86887.1 - 0.053 14.0 0.0 0.25 11.8 0.0 2.2 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Gelsolin PF00626.22 CRG86888.1 - 1.7e-34 117.5 0.8 5.8e-12 45.3 0.0 3.3 3 0 0 3 3 3 3 Gelsolin repeat Innexin PF00876.18 CRG86890.1 - 0.18 11.0 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Innexin Rad33 PF08730.10 CRG86891.1 - 0.074 13.1 0.2 0.13 12.3 0.2 1.4 1 0 0 1 1 1 0 Rad33 HAD_2 PF13419.6 CRG86892.1 - 2.1e-11 44.2 0.0 5.7e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG86892.1 - 0.037 14.3 0.0 0.21 11.9 0.0 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase MFS_1 PF07690.16 CRG86893.1 - 1.5e-17 63.6 30.0 1.5e-17 63.6 30.0 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily GST_N_3 PF13417.6 CRG86893.1 - 5.6e-05 23.5 0.0 0.00013 22.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain LapA_dom PF06305.11 CRG86893.1 - 0.0011 18.7 1.3 0.0043 16.8 0.3 2.4 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain GST_N_2 PF13409.6 CRG86893.1 - 0.012 15.9 0.0 0.035 14.4 0.0 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Cytochrom_B_C PF00032.17 CRG86893.1 - 0.37 11.1 2.2 1.4 9.3 0.9 2.4 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Polysacc_lyase PF14099.6 CRG86894.1 - 3.6e-48 164.2 11.9 4.1e-48 164.0 11.9 1.0 1 0 0 1 1 1 1 Polysaccharide lyase p450 PF00067.22 CRG86895.1 - 1.8e-64 218.2 0.0 2.2e-64 218.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_4 PF01565.23 CRG86896.1 - 1e-15 57.7 0.0 1.5e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain GalP_UDP_transf PF01087.22 CRG86897.1 - 2.2e-69 233.6 0.1 3.5e-68 229.6 0.0 2.1 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 CRG86897.1 - 7.7e-59 198.2 0.1 3.2e-58 196.2 0.1 1.8 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 CRG86897.1 - 0.0023 16.8 0.2 0.059 12.2 0.0 2.7 2 2 1 3 3 3 1 Domain of unknown function (DUF4921) Erg28 PF03694.13 CRG86898.1 - 2.9e-36 124.2 2.0 3.8e-36 123.8 2.0 1.1 1 0 0 1 1 1 1 Erg28 like protein adh_short PF00106.25 CRG86899.1 - 2.2e-38 131.7 0.0 3e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86899.1 - 8.8e-22 77.8 0.0 1.1e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86899.1 - 2.8e-05 24.1 0.0 5.7e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG86899.1 - 0.0004 19.6 0.0 0.00059 19.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CRG86899.1 - 0.4 10.9 2.0 0.51 10.6 0.1 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Sugar_tr PF00083.24 CRG86900.1 - 6.9e-133 443.8 31.6 8e-133 443.6 31.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86900.1 - 3.6e-24 85.4 53.2 4.5e-21 75.2 30.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2530 PF10745.9 CRG86900.1 - 0.0049 17.1 1.9 0.0049 17.1 1.9 4.1 6 0 0 6 6 6 1 Protein of unknown function (DUF2530) SnoaL_2 PF12680.7 CRG86901.1 - 0.0094 16.6 0.0 0.012 16.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CRG86901.1 - 0.018 14.9 0.0 0.032 14.0 0.0 1.5 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase 4HBT PF03061.22 CRG86902.1 - 2.3e-09 37.5 0.0 3.2e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily p450 PF00067.22 CRG86903.1 - 8.8e-62 209.3 0.0 1.2e-61 208.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG86904.1 - 1.3e-43 149.3 52.2 1.3e-43 149.3 52.2 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG86904.1 - 4.2e-14 51.9 22.1 5.3e-14 51.6 22.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2530 PF10745.9 CRG86904.1 - 0.051 13.8 12.2 1.4 9.2 3.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Na_K-ATPase PF00287.18 CRG86904.1 - 0.15 11.2 0.7 0.24 10.5 0.7 1.3 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain Zn_clus PF00172.18 CRG86905.1 - 5.4e-05 23.2 10.5 9.3e-05 22.5 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NCD3G PF07562.14 CRG86905.1 - 0.079 12.9 2.7 0.19 11.7 2.7 1.6 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR NOG1_N PF17835.1 CRG86907.1 - 4.3e-48 163.3 0.1 4.3e-48 163.3 0.1 2.6 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 CRG86907.1 - 8.6e-29 99.3 6.0 2e-28 98.1 6.0 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 CRG86907.1 - 9.4e-26 89.4 0.2 1.9e-25 88.4 0.2 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 CRG86907.1 - 1.4e-15 57.4 0.0 3.4e-15 56.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Acetyltransf_1 PF00583.25 CRG86907.1 - 3e-12 46.8 0.0 6.5e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG86907.1 - 1.7e-10 40.9 0.0 4.1e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG86907.1 - 1.5e-07 31.7 0.1 5.9e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FeoB_N PF02421.18 CRG86907.1 - 7.2e-07 28.9 0.0 2.1e-06 27.3 0.0 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CRG86907.1 - 0.0087 16.0 0.0 1.8 8.5 0.1 2.8 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CRG86907.1 - 0.0096 16.0 0.0 5.5 7.0 0.0 2.8 1 1 0 2 2 2 2 Dynamin family Acetyltransf_9 PF13527.7 CRG86907.1 - 0.014 15.5 0.0 0.034 14.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG86907.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein AAA_16 PF13191.6 CRG86907.1 - 0.045 14.1 0.1 0.3 11.4 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Asp_protease PF09668.10 CRG86908.1 - 7.5e-61 203.4 0.1 1.2e-60 202.7 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 CRG86908.1 - 1.3e-22 80.2 0.0 3.1e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CRG86908.1 - 3.5e-11 43.6 0.0 8.8e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.23 CRG86908.1 - 2.6e-10 39.9 0.0 4.2e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CRG86908.1 - 1.6e-08 34.3 0.0 5.1e-08 32.7 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain RVP PF00077.20 CRG86908.1 - 0.00037 20.7 0.1 0.0019 18.5 0.0 2.2 2 0 0 2 2 2 1 Retroviral aspartyl protease Rad60-SLD PF11976.8 CRG86908.1 - 0.0011 18.8 0.0 0.0023 17.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP_2 PF08284.11 CRG86908.1 - 0.0011 18.8 0.0 0.0025 17.6 0.0 1.5 1 1 0 1 1 1 1 Retroviral aspartyl protease UBA_4 PF14555.6 CRG86908.1 - 0.0038 17.0 0.0 0.0082 15.9 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain CUE PF02845.16 CRG86908.1 - 0.035 13.8 0.6 3.7 7.3 0.1 2.5 2 0 0 2 2 2 0 CUE domain DMA PF03474.14 CRG86908.1 - 0.075 12.6 0.2 0.17 11.5 0.2 1.6 1 0 0 1 1 1 0 DMRTA motif DUF2781 PF10914.8 CRG86909.1 - 4e-33 114.9 12.7 4.5e-33 114.7 12.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Nucleoporin_N PF08801.11 CRG86910.1 - 5.4e-93 312.1 0.4 7.4e-93 311.6 0.4 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 CRG86910.1 - 7.1e-53 180.3 3.0 2.7e-51 175.0 0.7 2.1 2 0 0 2 2 2 2 Non-repetitive/WGA-negative nucleoporin C-terminal YqeY PF09424.10 CRG86911.1 - 2.9e-17 63.1 0.2 3.3e-17 62.9 0.2 1.1 1 0 0 1 1 1 1 Yqey-like protein Rot1 PF10681.9 CRG86912.1 - 2.9e-90 301.4 0.1 3.3e-90 301.2 0.1 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal 5-FTHF_cyc-lig PF01812.20 CRG86913.1 - 2.1e-33 115.8 0.8 2.4e-29 102.5 0.0 2.4 2 1 0 2 2 2 2 5-formyltetrahydrofolate cyclo-ligase family GDPD PF03009.17 CRG86913.1 - 0.12 12.1 0.1 4.2 7.0 0.1 2.1 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family LSM PF01423.22 CRG86914.1 - 2.4e-13 49.5 0.1 2.8e-13 49.3 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 CRG86914.1 - 0.0013 18.4 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 Hfq protein Xpo1 PF08389.12 CRG86915.1 - 1.6e-26 93.2 0.2 9e-26 90.7 0.1 2.5 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 CRG86915.1 - 1e-06 28.5 0.1 4.4e-06 26.5 0.1 2.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain HEAT_EZ PF13513.6 CRG86915.1 - 0.0014 19.1 0.3 0.072 13.6 0.0 3.8 4 0 0 4 4 4 1 HEAT-like repeat Importin_rep_3 PF18806.1 CRG86915.1 - 0.024 14.6 0.0 0.15 12.1 0.0 2.5 2 0 0 2 2 2 0 Importin 13 repeat HEAT PF02985.22 CRG86915.1 - 0.03 14.6 0.0 37 4.9 0.0 3.9 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 CRG86915.1 - 0.04 14.3 0.0 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 HEAT repeats Fungal_trans PF04082.18 CRG86916.1 - 2.9e-61 206.9 0.0 4.3e-61 206.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG86916.1 - 0.00031 21.0 15.2 0.015 15.7 4.2 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type Abhydrolase_3 PF07859.13 CRG86917.1 - 5.9e-36 124.3 0.0 1.1e-35 123.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG86917.1 - 6.9e-05 21.9 0.0 8.4e-05 21.6 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 CRG86917.1 - 0.00085 18.3 0.0 0.01 14.7 0.0 2.0 2 0 0 2 2 2 1 Carboxylesterase family Peptidase_S9 PF00326.21 CRG86917.1 - 0.008 15.7 0.0 0.036 13.6 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family adh_short PF00106.25 CRG86918.1 - 2.4e-34 118.5 0.1 4e-34 117.8 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86918.1 - 5.3e-23 81.8 0.0 9.4e-23 81.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Abhydrolase_1 PF00561.20 CRG86918.1 - 4.1e-22 79.1 0.0 7e-21 75.0 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 CRG86918.1 - 1.3e-14 54.1 0.0 2.8e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein KR PF08659.10 CRG86918.1 - 0.0031 17.5 0.2 0.0089 15.9 0.2 1.7 1 1 0 1 1 1 1 KR domain EF-hand_7 PF13499.6 CRG86919.1 - 5e-12 46.1 0.4 7.4e-08 32.7 0.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 CRG86919.1 - 5.7e-11 42.6 0.0 2.3e-05 24.6 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 CRG86919.1 - 1.7e-08 33.7 0.4 0.013 15.3 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 CRG86919.1 - 2.9e-08 32.7 0.0 0.057 13.0 0.0 3.6 3 1 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 CRG86919.1 - 1.9e-06 27.6 0.2 0.00014 21.6 0.1 2.9 3 0 0 3 3 3 1 EF-hand domain pair DUF3216 PF11505.8 CRG86919.1 - 0.052 13.7 0.1 0.1 12.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3216) Eapp_C PF10238.9 CRG86920.1 - 0.03 14.4 2.0 0.61 10.2 1.1 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein SUIM_assoc PF16619.5 CRG86920.1 - 0.32 11.1 0.1 0.32 11.1 0.1 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Peptidase_M3 PF01432.20 CRG86921.1 - 1.4e-157 525.7 0.3 2.1e-157 525.0 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M3 RNA_pol_3_Rpc31 PF11705.8 CRG86921.1 - 0.16 12.2 2.8 0.19 11.9 0.4 2.3 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 FA_desaturase PF00487.24 CRG86922.1 - 2.1e-19 70.4 13.7 3.6e-19 69.6 13.7 1.4 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CRG86922.1 - 3.6e-17 62.3 0.3 9.2e-17 61.0 0.1 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF1189 PF06691.11 CRG86922.1 - 0.031 13.8 0.1 0.071 12.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) DUF2225 PF09986.9 CRG86922.1 - 0.099 12.4 0.0 0.23 11.1 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Xan_ur_permease PF00860.20 CRG86923.1 - 6.3e-69 232.5 30.7 2.8e-68 230.4 30.7 1.8 1 1 0 1 1 1 1 Permease family Sdh_cyt PF01127.22 CRG86924.1 - 1.5e-21 76.6 0.4 2.1e-21 76.2 0.4 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit BRO1 PF03097.18 CRG86924.1 - 0.064 12.1 0.1 0.082 11.7 0.1 1.1 1 0 0 1 1 1 0 BRO1-like domain Rad51 PF08423.11 CRG86925.1 - 1e-11 44.6 0.0 1.3e-08 34.5 0.0 2.1 2 0 0 2 2 2 2 Rad51 ATPase PF06745.13 CRG86925.1 - 0.00015 21.2 0.0 0.00025 20.5 0.0 1.5 1 1 0 1 1 1 1 KaiC RecA PF00154.21 CRG86925.1 - 0.00023 20.7 0.4 0.0007 19.1 0.0 1.9 3 0 0 3 3 3 1 recA bacterial DNA recombination protein IstB_IS21 PF01695.17 CRG86925.1 - 0.0014 18.4 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 CRG86925.1 - 0.0017 18.3 0.0 0.0037 17.2 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CRG86925.1 - 0.0027 17.3 0.2 0.0027 17.3 0.2 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG86925.1 - 0.0054 17.0 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG86925.1 - 0.014 15.8 0.0 0.029 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 CRG86925.1 - 0.031 14.0 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 CRG86925.1 - 0.032 14.3 0.2 0.046 13.8 0.2 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 CRG86925.1 - 0.038 14.4 0.0 0.076 13.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CRG86925.1 - 0.11 13.0 0.7 5.5 7.5 0.9 2.9 2 1 0 2 2 2 0 AAA domain PNP_UDP_1 PF01048.20 CRG86926.1 - 8.5e-10 38.3 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily Sas6_CC PF18594.1 CRG86926.1 - 0.12 12.1 0.1 0.41 10.5 0.1 1.8 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Mu-like_Pro PF10123.9 CRG86926.1 - 1.2 8.6 3.6 0.36 10.3 0.1 1.8 2 0 0 2 2 2 0 Mu-like prophage I protein zf-H2C2_2 PF13465.6 CRG86927.1 - 8.4e-06 26.0 27.2 5.7e-05 23.4 3.3 4.7 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 CRG86927.1 - 1.8e-05 24.9 14.0 0.00076 19.8 4.5 3.8 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG86927.1 - 0.019 15.8 19.8 0.053 14.4 3.0 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG86927.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 CRG86927.1 - 0.15 12.7 0.2 0.15 12.7 0.2 3.1 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 CRG86927.1 - 1.1 9.3 4.2 9 6.4 0.2 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger SAP30_Sin3_bdg PF13867.6 CRG86928.1 - 8.8e-08 32.4 0.7 1.8e-07 31.3 0.2 1.8 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 SR-25 PF10500.9 CRG86928.1 - 0.0072 16.0 5.4 0.0072 16.0 5.4 2.1 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Tic110 PF16940.5 CRG86928.1 - 0.38 9.2 4.5 0.55 8.6 4.5 1.2 1 0 0 1 1 1 0 Chloroplast envelope transporter NAM-associated PF14303.6 CRG86928.1 - 3.6 8.3 13.7 0.16 12.7 3.5 2.1 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain BRO1 PF03097.18 CRG86929.1 - 6.3e-131 436.7 6.4 6.3e-131 436.7 6.4 2.0 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 CRG86929.1 - 1.3e-80 270.9 11.9 1.3e-80 270.9 11.9 2.1 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Trimer_CC PF08954.11 CRG86929.1 - 0.0059 16.1 1.2 1.8 8.2 0.0 3.0 2 0 0 2 2 2 2 Trimerisation motif Pex19 PF04614.12 CRG86929.1 - 1.8 8.3 12.0 0.49 10.1 6.1 2.7 2 1 0 2 2 2 0 Pex19 protein family Fib_alpha PF08702.10 CRG86929.1 - 2.5 8.3 10.8 3.1 8.0 0.0 3.6 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family DnaJ_C PF01556.18 CRG86930.1 - 4.1e-33 114.6 0.0 5.6e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CRG86930.1 - 5.9e-23 80.8 0.4 1.1e-22 80.0 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CRG86930.1 - 2.6e-10 40.5 20.0 6.9e-10 39.1 20.0 1.8 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CRG86930.1 - 0.0031 17.5 3.4 0.0031 17.5 3.4 3.2 1 1 1 2 2 2 1 Tryptophan RNA-binding attenuator protein inhibitory protein Lon_C PF05362.13 CRG86931.1 - 4.7e-62 209.2 0.0 8.2e-62 208.4 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 CRG86931.1 - 8.8e-33 113.9 0.0 2.4e-32 112.5 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 CRG86931.1 - 1e-21 77.8 0.0 2.3e-21 76.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CRG86931.1 - 2.6e-07 30.7 0.0 5.2e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CRG86931.1 - 2.9e-06 27.5 0.1 1.1e-05 25.7 0.0 2.0 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_PrkA PF08298.11 CRG86931.1 - 4.7e-06 25.7 0.3 9.6e-06 24.7 0.0 1.6 2 0 0 2 2 2 1 PrkA AAA domain AAA_22 PF13401.6 CRG86931.1 - 9.3e-06 26.0 0.1 0.00012 22.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain ChlI PF13541.6 CRG86931.1 - 1.3e-05 25.0 0.0 4.5e-05 23.3 0.0 1.9 2 0 0 2 2 1 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 CRG86931.1 - 0.00013 22.4 1.0 0.00074 19.9 0.1 2.5 2 1 1 3 3 2 1 AAA ATPase domain RuvB_N PF05496.12 CRG86931.1 - 0.00016 21.5 0.0 0.00053 19.8 0.0 1.9 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CRG86931.1 - 0.0026 18.3 0.5 0.027 15.0 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 CRG86931.1 - 0.0055 16.7 0.0 0.013 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CRG86931.1 - 0.011 15.5 0.2 0.075 12.8 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF4276 PF14103.6 CRG86931.1 - 0.022 15.0 0.2 0.077 13.2 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4276) AAA_30 PF13604.6 CRG86931.1 - 0.024 14.4 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CRG86931.1 - 0.029 14.3 0.1 0.56 10.1 0.0 2.8 2 1 1 3 3 3 0 NTPase RNA_helicase PF00910.22 CRG86931.1 - 0.053 13.9 0.1 0.22 11.9 0.0 2.1 2 0 0 2 2 1 0 RNA helicase RsgA_GTPase PF03193.16 CRG86931.1 - 0.079 12.9 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 CRG86931.1 - 0.085 13.4 0.5 0.44 11.1 0.1 2.4 2 0 0 2 2 2 0 ABC transporter F-box-like_2 PF13013.6 CRG86931.1 - 0.15 12.1 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 F-box-like domain AAA_7 PF12775.7 CRG86931.1 - 0.15 11.6 0.0 0.35 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 CRG86931.1 - 0.16 11.9 0.0 0.97 9.3 0.0 2.5 2 1 0 2 2 1 0 NACHT domain DNTTIP1_dimer PF18192.1 CRG86931.1 - 0.49 10.8 2.6 35 4.8 0.3 3.3 3 0 0 3 3 2 0 DNTTIP1 dimerisation domain Pkinase PF00069.25 CRG86933.1 - 1.1e-11 44.7 0.0 3.4e-10 39.7 0.0 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG86933.1 - 6.2e-11 42.1 0.0 1.4e-09 37.6 0.0 2.5 1 1 0 1 1 1 1 Protein tyrosine kinase Ion_trans PF00520.31 CRG86934.1 - 0.0056 15.9 0.1 0.013 14.8 0.1 1.6 1 0 0 1 1 1 1 Ion transport protein FGF-BP1 PF06473.12 CRG86934.1 - 0.01 15.7 0.8 0.021 14.7 0.4 1.7 1 1 1 2 2 2 1 FGF binding protein 1 (FGF-BP1) OsmC PF02566.19 CRG86934.1 - 0.036 14.5 0.0 10 6.7 0.0 2.4 2 0 0 2 2 2 0 OsmC-like protein Phage_CP76 PF06892.11 CRG86934.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Phage regulatory protein CII (CP76) Mob1_phocein PF03637.17 CRG86935.1 - 2.1e-24 86.5 0.1 3.2e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family cobW PF02492.19 CRG86936.1 - 1.3e-46 158.4 0.0 1.7e-46 158.0 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 CRG86936.1 - 0.00022 21.2 0.2 0.36 10.7 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase CobW_C PF07683.14 CRG86936.1 - 0.0012 18.8 0.0 0.0024 17.7 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_16 PF13191.6 CRG86936.1 - 0.0033 17.8 0.0 0.0082 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 CRG86936.1 - 0.004 16.2 0.3 0.21 10.6 0.0 2.8 3 0 0 3 3 3 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CRG86936.1 - 0.0079 16.3 0.0 0.018 15.1 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG86936.1 - 0.0081 15.7 0.1 3.3 7.2 0.0 2.4 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CRG86936.1 - 0.026 14.8 0.3 0.17 12.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 CRG86936.1 - 0.035 14.0 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 CRG86936.1 - 0.048 13.4 0.2 0.18 11.6 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG86936.1 - 0.054 14.0 0.4 0.094 13.2 0.4 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CRG86936.1 - 0.073 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 CRG86936.1 - 0.088 11.8 0.2 0.18 10.9 0.2 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Subtilosin_A PF11420.8 CRG86936.1 - 0.095 12.7 1.2 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Bacteriocin subtilosin A AAA_18 PF13238.6 CRG86936.1 - 0.15 12.6 0.1 0.32 11.5 0.1 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CRG86936.1 - 0.17 12.4 0.1 0.45 11.0 0.1 1.7 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CRG86936.1 - 0.19 11.4 0.3 1.8 8.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain HAUS6_N PF14661.6 CRG86937.1 - 2.6e-43 148.2 0.2 5.3e-43 147.2 0.2 1.5 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus HD_3 PF13023.6 CRG86938.1 - 5e-48 163.2 0.2 6.3e-48 162.8 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 CRG86938.1 - 1.6e-12 47.5 0.1 2.2e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme PHM7_cyt PF14703.6 CRG86938.1 - 0.068 13.4 0.0 0.24 11.6 0.0 1.8 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter HD PF01966.22 CRG86938.1 - 0.099 12.9 0.2 0.37 11.0 0.2 1.9 1 1 0 1 1 1 0 HD domain Rad4 PF03835.15 CRG86939.1 - 2.1e-35 121.6 0.8 2.1e-35 121.6 0.8 2.3 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 CRG86939.1 - 5.6e-29 100.4 0.1 1.1e-28 99.4 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 HIT PF01230.23 CRG86939.1 - 1.6e-22 80.1 0.0 3.7e-22 78.9 0.0 1.6 1 0 0 1 1 1 1 HIT domain BHD_1 PF10403.9 CRG86939.1 - 1.1e-14 53.9 0.0 2.5e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 CRG86939.1 - 6.9e-14 52.5 0.4 6.9e-14 52.5 0.4 4.9 4 1 0 4 4 4 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 CRG86939.1 - 1.7e-05 25.3 0.0 5.1e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Transglutaminase-like superfamily DcpS_C PF11969.8 CRG86939.1 - 0.0011 19.5 0.0 0.0025 18.2 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding GalP_UDP_tr_C PF02744.17 CRG86939.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain PBP1_TM PF14812.6 CRG86939.1 - 0.16 12.4 0.2 0.16 12.4 0.2 6.9 7 1 0 7 7 7 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CoA_binding_2 PF13380.6 CRG86940.1 - 5.5e-28 97.8 0.0 6.5e-28 97.6 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain adh_short_C2 PF13561.6 CRG86941.1 - 2.3e-49 168.1 0.1 2.6e-49 167.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG86941.1 - 5e-42 143.6 0.3 5.7e-42 143.4 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG86941.1 - 3.6e-10 40.0 0.1 4.6e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 CRG86941.1 - 0.00043 19.5 0.0 0.00082 18.6 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 CRG86941.1 - 0.0029 17.1 0.0 0.032 13.7 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family USP19_linker PF16602.5 CRG86942.1 - 0.11 13.1 4.3 1.1 9.8 1.5 2.7 1 1 0 2 2 2 0 Linker region of USP19 deubiquitinase RrnaAD PF00398.20 CRG86944.1 - 3.7e-53 180.3 0.1 5.3e-53 179.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MIP-T3 PF10243.9 CRG86944.1 - 0.001 19.0 0.1 0.0035 17.3 0.1 1.8 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 CH-like domain Phage-tail_2 PF09096.10 CRG86944.1 - 0.065 13.2 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Baseplate structural protein, domain 2 Glyco_hydro_18 PF00704.28 CRG86945.1 - 9.2e-22 78.2 3.0 2.8e-20 73.3 3.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 MFS_1 PF07690.16 CRG86947.1 - 3.4e-31 108.4 38.7 9.2e-31 107.0 38.5 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG86947.1 - 0.001 18.4 9.0 0.001 18.4 9.0 2.5 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 CRG86947.1 - 0.0011 17.9 16.0 0.0019 17.1 16.0 1.3 1 0 0 1 1 1 1 MFS_1 like family DUF4190 PF13828.6 CRG86947.1 - 0.21 11.4 0.0 0.21 11.4 0.0 4.0 4 1 0 4 4 4 0 Domain of unknown function (DUF4190) M20_dimer PF07687.14 CRG86948.1 - 1e-08 35.0 0.0 2.6e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CRG86948.1 - 1.4e-06 28.2 0.1 2e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 FA_hydroxylase PF04116.13 CRG86949.1 - 3.6e-21 75.9 15.1 3.6e-21 75.9 15.1 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Lactamase_B_2 PF12706.7 CRG86950.1 - 3.2e-31 108.4 0.0 3e-30 105.3 0.0 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CRG86950.1 - 1.6e-12 47.7 0.0 1.5e-11 44.5 0.0 2.4 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CRG86950.1 - 9.7e-06 25.7 0.1 0.0037 17.3 0.0 2.4 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily MFS_1 PF07690.16 CRG86951.1 - 1.1e-18 67.4 33.2 2.4e-10 39.9 17.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86951.1 - 1.6e-14 53.6 23.0 2.1e-13 50.0 22.9 2.3 1 1 0 1 1 1 1 Sugar (and other) transporter HRI1 PF16815.5 CRG86952.1 - 2.8e-28 99.2 0.0 5.3e-28 98.3 0.0 1.5 1 1 0 1 1 1 1 Protein HRI1 Fungal_trans PF04082.18 CRG86953.1 - 0.00016 20.8 0.0 0.00029 20.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG86953.1 - 0.041 14.0 7.5 0.079 13.1 7.5 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain EutA PF06277.11 CRG86954.1 - 0.054 12.3 0.2 0.081 11.8 0.2 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation protein EutA ATP_transf PF09830.9 CRG86955.1 - 2.1e-17 63.0 0.0 5.9e-17 61.6 0.0 1.8 2 0 0 2 2 2 1 ATP adenylyltransferase Abhydrolase_1 PF00561.20 CRG86956.1 - 4.1e-13 49.6 0.0 5.4e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG86956.1 - 2.6e-10 41.3 4.6 3.6e-10 40.8 4.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG86956.1 - 2.7e-05 23.6 0.0 4.3e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CRG86956.1 - 0.00083 18.1 0.0 0.0013 17.5 0.0 1.2 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 CRG86956.1 - 0.016 15.0 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Thioesterase PF00975.20 CRG86956.1 - 0.11 12.6 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain p450 PF00067.22 CRG86957.1 - 1.9e-74 251.1 0.0 2.2e-74 250.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Thaumatin PF00314.17 CRG86958.1 - 0.31 10.6 9.5 1.5 8.4 9.5 2.2 1 1 0 1 1 1 0 Thaumatin family Acetyltransf_3 PF13302.7 CRG86959.1 - 2.8e-14 54.0 0.0 3.9e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NmrA PF05368.13 CRG86962.1 - 1.5e-26 93.4 0.1 1.9e-26 93.1 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG86962.1 - 1.2e-18 67.6 0.1 8.7e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding DapB_N PF01113.20 CRG86962.1 - 3.8e-05 23.8 1.6 7.1e-05 22.9 0.3 2.0 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 CRG86962.1 - 5.7e-05 23.5 0.7 0.00011 22.7 0.1 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CRG86962.1 - 0.00019 21.0 0.0 0.0019 17.7 0.0 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family PglD_N PF17836.1 CRG86962.1 - 0.042 14.5 0.1 0.12 13.0 0.1 1.8 1 0 0 1 1 1 0 PglD N-terminal domain 3Beta_HSD PF01073.19 CRG86962.1 - 0.087 11.8 0.5 0.2 10.6 0.1 1.8 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 CRG86962.1 - 0.12 11.7 0.1 0.36 10.1 0.1 1.7 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Fungal_trans PF04082.18 CRG86963.1 - 2.3e-13 49.8 0.1 3.4e-13 49.2 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sugar_tr PF00083.24 CRG86964.1 - 5.3e-69 233.2 20.5 6.5e-69 232.9 20.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG86964.1 - 2.4e-17 62.9 26.1 1.1e-15 57.4 22.9 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily Metallophos PF00149.28 CRG86965.1 - 5.7e-11 43.3 0.4 8.3e-11 42.8 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ABM PF03992.16 CRG86966.1 - 0.0069 16.5 2.1 0.06 13.5 0.3 2.2 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase ChpXY PF10216.9 CRG86966.1 - 0.033 13.3 0.0 0.046 12.9 0.0 1.1 1 0 0 1 1 1 0 CO2 hydration protein (ChpXY) PEP_mutase PF13714.6 CRG86967.1 - 6.8e-48 163.2 0.2 8.2e-48 162.9 0.2 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CRG86967.1 - 2.2e-17 62.8 0.2 2.9e-17 62.3 0.2 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PreAtp-grasp PF18604.1 CRG86967.1 - 0.061 13.0 0.1 4 7.1 0.0 2.4 2 0 0 2 2 2 0 Pre ATP-grasp domain Aconitase PF00330.20 CRG86968.1 - 4.2e-72 243.6 0.0 2.4e-70 237.8 0.0 2.2 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CRG86968.1 - 4.3e-16 59.4 0.0 9.4e-16 58.3 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain EF-hand_6 PF13405.6 CRG86968.1 - 0.054 13.4 0.0 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain FAD_binding_4 PF01565.23 CRG86969.1 - 4.1e-20 71.9 0.0 6.4e-20 71.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG86969.1 - 2.5e-06 27.5 0.1 6.4e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like Fungal_trans PF04082.18 CRG86970.1 - 1.5e-05 24.2 0.1 2.7e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Epimerase PF01370.21 CRG86971.1 - 2.5e-08 33.7 0.0 4.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG86971.1 - 6.6e-05 22.9 0.0 0.00027 20.9 0.0 2.1 2 1 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CRG86971.1 - 0.00092 18.4 0.0 0.7 8.9 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain 3Beta_HSD PF01073.19 CRG86971.1 - 0.0014 17.7 0.0 0.003 16.6 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ADH_zinc_N PF00107.26 CRG86971.1 - 0.011 15.7 0.0 0.13 12.2 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding dehydrogenase NmrA PF05368.13 CRG86971.1 - 0.017 14.7 0.0 0.029 13.9 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family NAD_binding_4 PF07993.12 CRG86971.1 - 0.043 13.0 0.0 3.2 6.9 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein Semialdhyde_dh PF01118.24 CRG86971.1 - 0.069 13.6 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 CRG86971.1 - 0.082 12.8 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 CRG86971.1 - 0.1 11.9 0.0 0.19 11.1 0.0 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DapB_N PF01113.20 CRG86971.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Pro_CA PF00484.19 CRG86972.1 - 9.6e-12 45.5 0.7 5.1e-11 43.1 0.4 1.9 1 1 0 2 2 2 1 Carbonic anhydrase Cys_Met_Meta_PP PF01053.20 CRG86973.1 - 7.1e-97 324.3 0.0 8.4e-97 324.1 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CRG86973.1 - 7.2e-05 22.3 2.4 0.00098 18.5 3.4 2.1 2 1 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CRG86973.1 - 7.5e-05 21.8 0.7 0.00013 21.1 0.7 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CRG86973.1 - 0.00088 18.6 0.1 0.0013 18.0 0.1 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase GDC-P PF02347.16 CRG86973.1 - 0.0056 15.6 0.0 0.008 15.1 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage system P-protein MFS_1 PF07690.16 CRG86974.1 - 1.1e-25 90.3 32.5 1.1e-25 90.3 32.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86975.1 - 2.3e-90 303.6 18.1 5.3e-52 177.2 2.7 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG86975.1 - 8.3e-32 110.5 40.9 2.8e-23 82.4 23.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG86975.1 - 0.00061 18.2 10.8 0.14 10.4 3.7 3.3 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family ABC2_membrane_5 PF13346.6 CRG86975.1 - 0.0032 17.1 7.7 0.0032 17.1 7.7 3.1 4 0 0 4 4 4 1 ABC-2 family transporter protein DIOX_N PF14226.6 CRG86976.1 - 8.7e-34 116.8 0.0 5e-31 107.9 0.0 2.4 2 0 0 2 2 2 2 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG86976.1 - 6.8e-13 49.0 0.0 1.8e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Abhydrolase_6 PF12697.7 CRG86976.1 - 6.4e-12 46.6 0.0 2.1e-11 44.9 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG86976.1 - 3.4e-06 26.5 0.0 1.4e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG86976.1 - 6.6e-06 26.0 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CRG86976.1 - 0.00036 20.4 0.0 0.00066 19.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CRG86976.1 - 0.0034 17.1 0.0 0.017 14.8 0.0 2.0 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_2 PF02230.16 CRG86976.1 - 0.0043 16.9 0.0 0.64 9.8 0.0 2.4 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase LIDHydrolase PF10230.9 CRG86976.1 - 0.0057 16.2 0.0 0.0096 15.5 0.0 1.3 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 CRG86976.1 - 0.0099 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Gly_transf_sug PF04488.15 CRG86977.1 - 4.1e-15 56.2 0.0 7.8e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif MLANA PF14991.6 CRG86977.1 - 0.069 13.4 0.2 1.7 8.9 0.0 2.2 2 0 0 2 2 2 0 Protein melan-A DUF4859 PF16151.5 CRG86978.1 - 0.42 10.5 1.8 2.1 8.2 1.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4859) Acetyltransf_10 PF13673.7 CRG86979.1 - 0.17 11.8 0.0 0.23 11.4 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain LapA_dom PF06305.11 CRG86980.1 - 0.0085 15.9 0.9 0.016 15.0 0.9 1.4 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain CYYR1 PF10873.8 CRG86980.1 - 0.45 10.9 0.1 0.45 10.9 0.1 2.9 3 1 0 3 3 3 0 Cysteine and tyrosine-rich protein 1 NTP_transf_9 PF04248.12 CRG86981.1 - 6.1e-33 112.6 0.8 3.7e-26 90.8 0.1 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF427) Zn_clus PF00172.18 CRG86982.1 - 0.0029 17.7 11.6 0.045 13.9 11.6 2.3 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CCDC106 PF15794.5 CRG86982.1 - 0.014 15.2 0.8 0.025 14.3 0.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Glyco_transf_54 PF04666.13 CRG86983.1 - 7.7e-16 57.8 0.0 1.6e-06 27.2 0.0 3.1 3 0 0 3 3 3 3 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region MFS_1 PF07690.16 CRG86983.1 - 0.12 11.3 2.7 0.22 10.4 2.7 1.4 1 0 0 1 1 1 0 Major Facilitator Superfamily MFS_1 PF07690.16 CRG86984.1 - 6.1e-16 58.3 51.6 5.7e-15 55.1 49.5 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Abhydrolase_4 PF08386.10 CRG86985.1 - 7.5e-24 83.8 0.0 1.6e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 CRG86985.1 - 2.9e-16 59.9 0.0 3.9e-12 46.4 0.0 3.2 2 1 0 2 2 2 2 alpha/beta hydrolase fold Fungal_trans PF04082.18 CRG86985.1 - 1.9e-13 50.1 0.0 3.3e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG86986.1 - 6.7e-44 149.7 0.0 9.3e-44 149.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG86986.1 - 3.4e-36 125.0 0.0 4.3e-36 124.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG86986.1 - 2e-11 44.1 0.0 2.8e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG86986.1 - 0.00012 21.6 0.0 0.00017 21.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CRG86986.1 - 0.00027 20.9 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG86986.1 - 0.00091 18.8 0.0 0.0018 17.8 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG86986.1 - 0.0034 17.0 0.2 0.013 15.1 0.1 1.8 2 0 0 2 2 2 1 NmrA-like family RmlD_sub_bind PF04321.17 CRG86986.1 - 0.043 12.9 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain SnoaL_2 PF12680.7 CRG86987.1 - 9.6e-08 32.6 0.1 1.2e-07 32.3 0.1 1.2 1 0 0 1 1 1 1 SnoaL-like domain FAD_binding_3 PF01494.19 CRG86988.1 - 4.2e-18 65.7 0.3 3.8e-13 49.4 0.0 2.4 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CRG86988.1 - 0.00032 20.0 0.4 0.0018 17.6 0.1 1.8 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG86988.1 - 0.0021 17.2 0.0 0.0037 16.4 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG86988.1 - 0.008 16.4 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CRG86988.1 - 0.012 14.8 0.1 0.02 14.1 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG86988.1 - 0.031 13.3 0.2 0.046 12.8 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 CRG86988.1 - 0.061 12.5 0.0 0.099 11.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 CRG86988.1 - 0.069 12.7 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase PEP_mutase PF13714.6 CRG86989.1 - 3.8e-54 183.7 0.1 4.5e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CRG86989.1 - 3.4e-13 48.9 0.1 5e-13 48.4 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Pantoate_transf PF02548.15 CRG86989.1 - 0.0037 16.7 0.0 0.016 14.6 0.0 1.9 2 0 0 2 2 2 1 Ketopantoate hydroxymethyltransferase Aa_trans PF01490.18 CRG86990.1 - 1.9e-39 135.5 37.6 2.4e-39 135.2 37.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CRG86990.1 - 0.00011 21.3 17.4 0.00024 20.3 17.4 1.7 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family DUF5325 PF17259.2 CRG86990.1 - 0.039 13.8 1.0 0.039 13.8 1.0 5.3 7 0 0 7 7 7 0 Family of unknown function (DUF5325) CAAD PF14159.6 CRG86990.1 - 1.4 8.8 10.6 0.44 10.4 0.5 3.4 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase AA_permease PF00324.21 CRG86991.1 - 4e-102 342.3 40.6 4.6e-102 342.1 40.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG86991.1 - 5.2e-26 91.4 44.7 6.4e-26 91.1 44.7 1.1 1 0 0 1 1 1 1 Amino acid permease Glyco_hydro_11 PF00457.17 CRG86992.1 - 1.8e-81 272.0 16.5 2.1e-81 271.8 16.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 DUF4267 PF14087.6 CRG86993.1 - 1.1e-24 86.7 2.4 1.2e-24 86.5 2.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) Tetraspanin PF00335.20 CRG86993.1 - 0.13 11.9 0.4 0.18 11.5 0.4 1.2 1 0 0 1 1 1 0 Tetraspanin family Cellulase PF00150.18 CRG86994.1 - 2.5e-17 63.2 10.3 3.3e-17 62.8 10.3 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ocr PF08684.10 CRG86995.1 - 0.021 15.3 0.0 0.027 14.9 0.0 1.1 1 0 0 1 1 1 0 DNA mimic ocr E3_binding PF02817.17 CRG86995.1 - 0.057 13.8 0.0 3.2 8.2 0.0 2.5 2 0 0 2 2 2 0 e3 binding domain Asp PF00026.23 CRG86996.1 - 3.6e-71 240.2 13.7 4.3e-71 239.9 13.7 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG86996.1 - 9.4e-08 32.5 2.8 0.00029 21.1 0.5 2.6 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG86996.1 - 0.0021 18.6 2.6 0.21 12.3 0.4 2.8 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 CRG86996.1 - 0.011 15.6 0.0 0.095 12.5 0.0 2.3 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal MFS_1 PF07690.16 CRG86997.1 - 2.2e-28 99.2 34.4 2.2e-28 99.2 34.4 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG86997.1 - 1.4e-10 40.7 7.9 1.4e-10 40.7 7.9 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter Sugar_tr PF00083.24 CRG86998.1 - 3.1e-121 405.4 28.9 3.1e-121 405.4 28.9 2.7 3 0 0 3 3 3 1 Sugar (and other) transporter AA_permease_2 PF13520.6 CRG86998.1 - 1.9e-53 181.9 52.2 1.9e-53 181.9 52.2 3.9 3 1 0 3 3 3 1 Amino acid permease PP2C PF00481.21 CRG86998.1 - 1.2e-27 97.2 0.0 2.1e-27 96.4 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C MFS_1 PF07690.16 CRG86998.1 - 3e-27 95.5 30.6 3e-27 95.5 30.6 4.8 1 1 2 4 4 4 1 Major Facilitator Superfamily AA_permease PF00324.21 CRG86998.1 - 1.3e-16 60.3 42.7 1.3e-16 60.3 42.7 2.2 3 0 0 3 3 3 1 Amino acid permease PP2C_2 PF13672.6 CRG86998.1 - 0.0055 16.4 0.1 0.014 15.1 0.0 1.6 2 0 0 2 2 2 1 Protein phosphatase 2C Epiglycanin_C PF14654.6 CRG86998.1 - 0.062 13.4 1.0 22 5.2 0.1 3.6 3 0 0 3 3 3 0 Mucin, catalytic, TM and cytoplasmic tail region DDE_Tnp_IS1 PF03400.13 CRG86998.1 - 0.1 13.0 0.2 0.29 11.5 0.0 1.8 2 0 0 2 2 2 0 IS1 transposase CcmD PF04995.14 CRG86998.1 - 0.36 10.9 2.2 2.6 8.2 2.2 2.5 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Amidoligase_2 PF12224.8 CRG86999.1 - 1.7e-08 34.5 0.0 2.1e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Putative amidoligase enzyme adh_short_C2 PF13561.6 CRG87000.1 - 2.4e-59 200.7 1.4 2.8e-59 200.5 1.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87000.1 - 2.3e-43 148.0 0.1 2.8e-43 147.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87000.1 - 5.8e-11 42.6 0.8 9e-11 42.0 0.8 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG87000.1 - 0.00043 19.5 0.0 0.00061 19.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CRG87000.1 - 0.00078 19.0 0.1 0.0068 15.9 0.1 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG87000.1 - 0.0048 16.3 0.1 0.007 15.8 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 CRG87000.1 - 0.0051 16.7 0.3 0.0075 16.2 0.3 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CRG87000.1 - 0.02 15.3 0.1 0.032 14.7 0.1 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding TrkA_N PF02254.18 CRG87000.1 - 0.045 14.0 0.7 0.098 12.9 0.2 1.9 2 0 0 2 2 2 0 TrkA-N domain Ldh_1_N PF00056.23 CRG87000.1 - 0.16 12.0 0.5 0.41 10.7 0.5 1.7 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain AP_endonuc_2 PF01261.24 CRG87001.1 - 2.7e-28 98.9 0.0 3.7e-28 98.4 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel LPMO_10 PF03067.15 CRG87003.1 - 0.00038 21.2 0.2 0.00085 20.0 0.2 1.6 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 CRG87003.1 - 0.0047 16.9 0.0 0.011 15.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 Transp_cyt_pur PF02133.15 CRG87004.1 - 2.2e-21 76.2 37.3 5.1e-21 75.0 37.3 1.6 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin UPF0139 PF03669.13 CRG87004.1 - 0.024 14.5 0.4 0.085 12.7 0.4 2.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) Glyco_hydro_28 PF00295.17 CRG87005.1 - 5.5e-12 45.4 0.8 8.1e-12 44.8 0.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Sugar_tr PF00083.24 CRG87006.1 - 8.1e-16 57.9 0.0 9.3e-16 57.7 0.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter ADH_zinc_N PF00107.26 CRG87007.1 - 4.9e-11 42.7 0.0 6.3e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG87007.1 - 0.00077 20.5 0.0 0.0013 19.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase MFS_1 PF07690.16 CRG87008.1 - 3.4e-34 118.3 38.0 1.5e-33 116.2 38.0 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1772 PF08592.11 CRG87008.1 - 5.1 7.4 21.4 2.3 8.5 0.3 5.0 2 2 0 4 4 4 0 Domain of unknown function (DUF1772) DUF4148 PF13663.6 CRG87010.1 - 0.039 14.1 0.2 0.065 13.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) APH PF01636.23 CRG87011.1 - 9.6e-16 58.4 0.2 3e-14 53.5 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG87011.1 - 0.072 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Phage_Cox PF10743.9 CRG87011.1 - 0.11 12.6 0.0 0.33 11.1 0.0 1.8 1 0 0 1 1 1 0 Regulatory phage protein cox Haspin_kinase PF12330.8 CRG87011.1 - 0.17 10.8 0.0 0.34 9.8 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Zn_clus PF00172.18 CRG87012.1 - 0.00044 20.3 4.1 0.0011 19.0 4.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG87012.1 - 0.001 18.1 0.0 0.0023 17.0 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain PSI_integrin PF17205.3 CRG87012.1 - 0.6 9.9 3.8 1.8 8.3 3.8 1.8 1 0 0 1 1 1 0 Integrin plexin domain NAD_binding_10 PF13460.6 CRG87013.1 - 9.7e-05 22.3 0.0 0.00011 22.1 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 CRG87013.1 - 0.0022 18.4 0.0 0.0041 17.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CRG87013.1 - 0.021 14.3 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF4965 PF16335.5 CRG87014.1 - 4e-71 238.2 0.6 1e-70 236.9 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4965) DUF5127 PF17168.4 CRG87014.1 - 1.5e-67 227.7 7.5 2.2e-67 227.2 7.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF1793 PF08760.11 CRG87014.1 - 3.5e-65 219.5 0.2 9.4e-65 218.1 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 CRG87014.1 - 5.3e-05 22.7 0.5 0.00022 20.7 0.5 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4964) Abhydrolase_6 PF12697.7 CRG87015.1 - 1e-06 29.6 1.4 1.8e-06 28.7 1.4 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIP PF03583.14 CRG87015.1 - 1.8e-05 24.2 0.5 0.022 14.1 0.0 2.4 2 0 0 2 2 2 2 Secretory lipase Hydrolase_4 PF12146.8 CRG87015.1 - 2.9e-05 23.4 0.0 0.072 12.3 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CRG87015.1 - 0.00019 21.0 0.1 0.063 12.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CRG87015.1 - 0.0013 18.4 1.1 0.055 13.1 0.0 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold FSH1 PF03959.13 CRG87015.1 - 0.013 15.2 0.1 0.067 12.8 0.1 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 CRG87015.1 - 0.018 14.9 0.1 0.082 12.8 0.1 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Fungal_trans PF04082.18 CRG87016.1 - 3.9e-20 72.0 0.1 7.9e-20 71.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Aldolase_II PF00596.21 CRG87017.1 - 2.3e-47 161.3 0.1 2.9e-47 161.0 0.1 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ADH_zinc_N PF00107.26 CRG87018.1 - 1.6e-23 83.1 0.1 2.5e-23 82.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG87018.1 - 2.1e-19 70.9 0.0 3.5e-19 70.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG87018.1 - 7.8e-08 32.2 0.0 3.8e-07 30.0 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Amidohydro_2 PF04909.14 CRG87019.1 - 6.8e-19 68.7 0.5 1.4e-18 67.8 0.5 1.6 1 1 0 1 1 1 1 Amidohydrolase MFS_1 PF07690.16 CRG87020.1 - 3.9e-33 114.8 24.7 3.9e-33 114.8 24.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG87020.1 - 5.7e-23 81.5 23.0 2.6e-22 79.3 23.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter peroxidase PF00141.23 CRG87021.1 - 3.8e-81 272.1 0.0 1.9e-42 145.6 0.0 2.3 2 0 0 2 2 2 2 Peroxidase Fungal_trans PF04082.18 CRG87021.1 - 2.6e-24 85.7 0.0 4e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 CRG87022.1 - 0.00063 18.9 0.0 0.0028 16.7 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain NAD_binding_10 PF13460.6 CRG87023.1 - 4.9e-21 75.5 0.0 5.6e-21 75.3 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG87023.1 - 8.9e-06 25.3 0.0 1.2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG87023.1 - 0.0039 16.8 0.0 0.0057 16.3 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CRG87023.1 - 0.021 14.0 0.0 0.03 13.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_5 PF07994.12 CRG87023.1 - 0.068 12.5 0.0 0.095 12.1 0.0 1.1 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase Beta-lactamase PF00144.24 CRG87024.1 - 1.2e-22 80.6 0.0 2.5e-22 79.6 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase Apo-CII PF05355.11 CRG87024.1 - 0.0093 16.1 1.5 0.061 13.5 0.2 2.3 2 0 0 2 2 2 1 Apolipoprotein C-II Abhydrolase_1 PF00561.20 CRG87025.1 - 1.2e-05 25.1 0.2 0.00011 22.0 0.0 2.0 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG87025.1 - 0.0026 17.1 0.0 0.0044 16.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 AA_permease_2 PF13520.6 CRG87026.1 - 3.3e-41 141.5 57.1 3.4e-40 138.2 57.1 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG87026.1 - 3.4e-23 82.0 56.6 1.7e-21 76.4 56.6 2.0 1 1 0 1 1 1 1 Amino acid permease GAPT PF11770.8 CRG87026.1 - 0.081 12.8 5.4 0.12 12.2 0.6 2.8 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) DUF5381 PF17353.2 CRG87026.1 - 0.39 10.5 4.1 1.8 8.3 4.1 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5381) FAD_binding_3 PF01494.19 CRG87027.1 - 1.4e-05 24.5 0.0 1.7e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Hydantoinase_B PF02538.14 CRG87028.1 - 1.2e-215 716.8 0.7 1.6e-215 716.4 0.7 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CRG87028.1 - 2.5e-102 342.1 0.0 6.3e-102 340.8 0.0 1.7 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CRG87028.1 - 1e-59 201.2 0.7 5e-58 195.7 0.0 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Aminotran_1_2 PF00155.21 CRG87028.1 - 2.2e-55 188.3 0.0 3.4e-55 187.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DHDPS PF00701.22 CRG87029.1 - 5.2e-44 150.1 0.0 6.4e-44 149.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family PEP_mutase PF13714.6 CRG87029.1 - 0.011 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate phosphomutase Methyltransf_18 PF12847.7 CRG87029.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HsbA PF12296.8 CRG87030.1 - 1.2e-24 87.0 9.4 1.2e-24 87.0 9.4 2.1 2 0 0 2 2 2 1 Hydrophobic surface binding protein A Effector_1 PF04518.12 CRG87030.1 - 0.014 14.5 1.0 0.023 13.8 0.8 1.3 1 1 0 1 1 1 0 Effector from type III secretion system FAD_binding_3 PF01494.19 CRG87031.1 - 1.1e-07 31.5 0.1 4.7e-07 29.4 0.1 1.8 1 1 0 1 1 1 1 FAD binding domain p450 PF00067.22 CRG87032.1 - 1e-71 242.1 0.0 1.3e-71 241.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 CRG87032.1 - 7e-21 74.8 0.0 1.2e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CRG87032.1 - 1.5e-19 70.6 0.0 2.9e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CRG87032.1 - 2.4e-10 41.0 0.1 9.9e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Sugar_tr PF00083.24 CRG87033.1 - 4.1e-61 207.2 13.2 4.8e-61 207.0 13.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG87033.1 - 7.6e-15 54.7 68.9 2.5e-13 49.7 37.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG87033.1 - 7.1e-08 31.4 3.9 7.1e-08 31.4 3.9 2.6 2 1 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 CRG87033.1 - 0.75 8.6 9.9 0.01 14.7 1.5 2.2 2 1 1 3 3 3 0 MFS_1 like family MFS_1 PF07690.16 CRG87034.1 - 4.1e-43 147.7 30.5 7.3e-43 146.8 30.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG87034.1 - 4.5e-12 45.6 0.5 4.5e-12 45.6 0.5 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter Dioxygenase_C PF00775.21 CRG87035.1 - 8.2e-40 136.2 0.0 1.1e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CRG87035.1 - 6.3e-24 83.6 0.0 9.4e-24 83.1 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CSS-motif PF12792.7 CRG87035.1 - 0.057 12.9 0.1 0.091 12.2 0.1 1.3 1 0 0 1 1 1 0 CSS motif domain associated with EAL SpaA PF17802.1 CRG87035.1 - 0.14 12.5 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Prealbumin-like fold domain DUF1254 PF06863.12 CRG87036.1 - 0.0002 21.4 1.0 0.0011 19.1 0.4 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF1254) Methyltransf_2 PF00891.18 CRG87037.1 - 5.9e-19 68.2 0.0 9.9e-19 67.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Peptidase_A4 PF01828.17 CRG87037.1 - 0.00089 18.8 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase A4 family Dimerisation2 PF16864.5 CRG87037.1 - 0.13 12.3 0.0 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain DLH PF01738.18 CRG87039.1 - 2.8e-32 112.0 0.1 3.3e-32 111.8 0.1 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 CRG87039.1 - 0.099 12.1 0.0 0.3 10.5 0.0 1.6 1 1 1 2 2 2 0 Prolyl oligopeptidase family DUF915 PF06028.11 CRG87039.1 - 0.15 11.3 0.0 0.4 10.0 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Annexin PF00191.20 CRG87040.1 - 1.9e-50 168.8 4.3 2.9e-15 56.1 0.0 4.5 4 0 0 4 4 4 4 Annexin Fungal_trans PF04082.18 CRG87040.1 - 2.1e-11 43.4 0.1 3.4e-11 42.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain EamA PF00892.20 CRG87041.1 - 3.5e-05 24.0 3.8 3.5e-05 24.0 3.8 2.4 2 1 0 2 2 2 1 EamA-like transporter family PHO4 PF01384.20 CRG87041.1 - 0.01 14.9 1.2 0.01 14.9 1.2 2.2 2 0 0 2 2 2 0 Phosphate transporter family Multi_Drug_Res PF00893.19 CRG87041.1 - 0.17 12.5 10.5 0.32 11.7 3.0 2.9 2 1 0 2 2 2 0 Small Multidrug Resistance protein RTA1 PF04479.13 CRG87042.1 - 2.1e-35 122.2 0.3 2.5e-35 122.0 0.3 1.0 1 0 0 1 1 1 1 RTA1 like protein DUF1129 PF06570.11 CRG87042.1 - 0.041 13.4 0.1 0.059 12.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) MFS_1 PF07690.16 CRG87043.1 - 6.8e-23 81.2 18.0 7.6e-22 77.7 19.8 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 CRG87044.1 - 3.5e-19 69.7 0.0 2.4e-18 67.0 0.0 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG87044.1 - 4.1e-11 43.3 0.0 8.5e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily COesterase PF00135.28 CRG87045.1 - 3e-82 277.2 0.0 3.6e-82 276.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG87045.1 - 0.0048 16.8 1.0 0.01 15.7 0.3 1.9 2 1 0 2 2 2 1 alpha/beta hydrolase fold Phosphodiest PF01663.22 CRG87046.1 - 8.1e-29 101.3 0.0 1.4e-28 100.5 0.0 1.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Methyltransf_3 PF01596.17 CRG87047.1 - 1.1e-09 37.8 0.0 1.4e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CRG87047.1 - 1.3e-09 39.0 0.0 2.2e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CmcI PF04989.12 CRG87047.1 - 0.00012 21.8 0.0 0.00018 21.3 0.0 1.2 1 0 0 1 1 1 1 Cephalosporin hydroxylase Fungal_trans_2 PF11951.8 CRG87048.1 - 9.7e-07 27.9 0.0 1.9e-06 26.9 0.0 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF4407 PF14362.6 CRG87049.1 - 0.91 8.8 9.2 1.3 8.3 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Alb1 PF09135.11 CRG87049.1 - 2.7 8.9 22.4 4.8 8.1 2.3 2.5 2 0 0 2 2 2 0 Alb1 adh_short PF00106.25 CRG87050.1 - 2.1e-21 76.3 0.0 2.9e-20 72.6 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87050.1 - 7.1e-14 51.9 0.0 3.1e-13 49.8 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG87050.1 - 0.00033 20.6 0.0 0.00061 19.7 0.0 1.5 1 1 0 1 1 1 1 KR domain DUF3425 PF11905.8 CRG87051.1 - 1e-18 67.5 0.2 1.7e-18 66.8 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Questin_oxidase PF14027.6 CRG87052.1 - 2.3e-69 234.5 0.0 3.5e-69 234.0 0.0 1.2 1 0 0 1 1 1 1 Questin oxidase-like Amidohydro_1 PF01979.20 CRG87052.1 - 3.2e-16 59.6 0.0 6.6e-16 58.5 0.0 1.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG87052.1 - 3.2e-08 33.5 0.0 0.00028 20.5 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family NAD_binding_10 PF13460.6 CRG87052.1 - 0.00052 19.9 0.0 0.004 17.1 0.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding DRE2_N PF16803.5 CRG87052.1 - 0.044 14.0 0.5 6.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus FAD_binding_3 PF01494.19 CRG87053.1 - 2.4e-18 66.5 0.0 3.7e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG87053.1 - 5.3e-08 32.4 0.1 0.00022 20.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG87053.1 - 5.3e-07 29.8 0.3 1.6e-06 28.3 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG87053.1 - 3e-05 23.8 5.1 0.011 15.3 3.0 2.6 2 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG87053.1 - 0.00011 21.5 1.0 0.00018 20.7 1.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 CRG87053.1 - 0.00018 22.0 0.0 0.0027 18.3 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG87053.1 - 0.00087 18.1 0.7 0.0087 14.8 0.5 2.0 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CRG87053.1 - 0.0042 16.2 0.7 0.018 14.1 0.6 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 CRG87053.1 - 0.045 13.1 0.6 0.076 12.3 0.6 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG87053.1 - 0.095 11.9 1.4 0.32 10.2 1.8 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG87053.1 - 0.11 11.8 0.2 0.24 10.6 0.2 1.6 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CRG87053.1 - 0.12 11.2 1.2 1.3 7.8 0.3 2.6 3 0 0 3 3 3 0 Tryptophan halogenase DUF3328 PF11807.8 CRG87054.1 - 1.3e-52 178.8 0.2 1.6e-52 178.5 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Pex2_Pex12 PF04757.14 CRG87054.1 - 0.085 12.4 0.0 0.26 10.9 0.0 1.7 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region Adeno_terminal PF02459.15 CRG87054.1 - 0.13 10.6 0.1 0.19 10.1 0.1 1.2 1 0 0 1 1 1 0 Adenoviral DNA terminal protein Tweety PF04906.13 CRG87054.1 - 0.16 10.6 0.0 0.41 9.3 0.0 1.5 2 0 0 2 2 2 0 Tweety MmgE_PrpD PF03972.14 CRG87055.1 - 1.3e-120 402.9 2.2 1.6e-120 402.6 2.2 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Glyco_hydro_64 PF16483.5 CRG87056.1 - 1.5e-113 379.8 0.8 1.7e-113 379.6 0.8 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase Caps_synth PF05704.12 CRG87057.1 - 5.2e-14 52.3 0.0 7.5e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 CRG87057.1 - 4.6e-06 27.2 0.1 1.2e-05 25.9 0.1 1.7 1 1 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif adh_short PF00106.25 CRG87058.1 - 1.9e-33 115.6 0.0 2.6e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87058.1 - 4.7e-18 65.6 0.0 5.7e-18 65.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG87058.1 - 8e-06 25.9 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CRG87058.1 - 0.00021 21.6 0.2 0.00054 20.2 0.2 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG87058.1 - 0.00059 19.4 0.1 0.0035 16.9 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 CRG87058.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase DUF1776 PF08643.10 CRG87058.1 - 0.0041 16.5 0.1 0.0057 16.1 0.1 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 CRG87058.1 - 0.0077 16.1 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding CoA_binding_2 PF13380.6 CRG87058.1 - 0.052 14.0 0.0 0.094 13.2 0.0 1.4 1 0 0 1 1 1 0 CoA binding domain Polysacc_synt_2 PF02719.15 CRG87058.1 - 0.057 12.5 0.1 0.1 11.7 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF3189 PF11385.8 CRG87058.1 - 0.081 12.8 0.0 0.39 10.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3189) THF_DHG_CYH_C PF02882.19 CRG87058.1 - 0.13 11.6 0.0 0.28 10.5 0.0 1.5 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_2 PF03446.15 CRG87058.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CRG87058.1 - 0.2 11.0 0.3 0.47 9.8 0.2 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NUP PF06516.11 CRG87059.1 - 9.3e-136 452.1 0.0 1.1e-135 451.9 0.0 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) Transferase PF02458.15 CRG87060.1 - 3.9e-08 32.4 0.0 4.6e-05 22.3 0.0 2.1 2 0 0 2 2 2 2 Transferase family MFS_1 PF07690.16 CRG87061.1 - 1.8e-09 37.0 29.8 3.4e-09 36.1 29.8 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG87061.1 - 5.5e-08 32.7 4.8 5.5e-08 32.7 4.8 3.1 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Cupin_5 PF06172.11 CRG87062.1 - 5.8e-49 165.9 0.0 7e-49 165.6 0.0 1.1 1 0 0 1 1 1 1 Cupin superfamily (DUF985) MFS_1 PF07690.16 CRG87064.1 - 2.6e-33 115.4 26.5 2.6e-33 115.4 26.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily LapA_dom PF06305.11 CRG87064.1 - 0.026 14.3 0.1 0.14 12.0 0.1 2.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DIOX_N PF14226.6 CRG87065.1 - 7.1e-15 55.8 0.0 1.6e-14 54.7 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG87065.1 - 1.9e-12 47.5 0.0 3.2e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily VCBS PF13517.6 CRG87066.1 - 1.4e-11 44.8 18.1 4.8e-06 27.1 0.7 3.6 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 CRG87066.1 - 3.9e-07 29.6 3.2 0.07 12.5 0.1 3.4 2 1 1 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region FG-GAP PF01839.23 CRG87066.1 - 3.3e-05 23.9 8.8 0.47 10.6 0.3 4.1 4 0 0 4 4 4 3 FG-GAP repeat EF-hand_1 PF00036.32 CRG87066.1 - 0.00021 20.6 5.2 1.6 8.5 0.2 3.8 4 0 0 4 4 4 2 EF hand DUF1905 PF08922.11 CRG87066.1 - 0.0011 19.0 0.6 0.75 9.9 0.0 3.9 1 1 3 4 4 4 1 Domain of unknown function (DUF1905) DUF3642 PF12182.8 CRG87066.1 - 0.0014 18.8 6.2 2.7 8.3 0.0 4.0 3 1 1 4 4 4 2 Bacterial lipoprotein EF-hand_6 PF13405.6 CRG87066.1 - 0.0063 16.4 4.4 3 8.0 0.2 3.9 4 0 0 4 4 4 1 EF-hand domain PliI PF16743.5 CRG87066.1 - 0.01 15.6 3.0 0.28 11.0 0.3 3.3 2 1 1 3 3 3 0 Periplasmic lysozyme inhibitor of I-type lysozyme CBM_6 PF03422.15 CRG87066.1 - 0.02 15.2 13.9 2.2 8.6 0.7 4.5 1 1 4 5 5 5 0 Carbohydrate binding module (family 6) MYT1 PF08474.11 CRG87066.1 - 0.062 13.2 0.1 4.3 7.2 0.0 2.8 1 1 2 3 3 3 0 Myelin transcription factor 1 EF-hand_4 PF12763.7 CRG87066.1 - 0.1 12.6 2.9 35 4.4 0.0 3.8 4 0 0 4 4 4 0 Cytoskeletal-regulatory complex EF hand Crystall_2 PF09076.10 CRG87066.1 - 0.14 12.1 0.4 0.14 12.1 0.4 3.6 3 1 1 4 4 4 0 Beta/Gamma crystallin EF-hand_5 PF13202.6 CRG87066.1 - 0.14 11.7 8.9 1.5 8.4 0.2 3.1 3 0 0 3 3 3 0 EF hand EF-hand_7 PF13499.6 CRG87066.1 - 2.7 8.5 4.5 41 4.7 0.2 3.2 3 1 0 3 3 3 0 EF-hand domain pair Hydrophobin PF01185.18 CRG87067.1 - 1.7e-12 47.8 14.2 2.4e-12 47.3 14.2 1.2 1 0 0 1 1 1 1 Fungal hydrophobin DEC-1_N PF04625.13 CRG87067.1 - 1.1 8.2 10.3 1.3 8.0 10.3 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Mito_fiss_reg PF05308.11 CRG87067.1 - 2 8.5 6.5 2.6 8.1 6.5 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator TelA PF05816.11 CRG87068.1 - 0.06 12.4 1.3 0.09 11.8 1.3 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Occludin_ELL PF07303.13 CRG87068.1 - 0.099 13.4 2.1 0.4 11.4 0.1 2.7 1 1 1 2 2 2 0 Occludin homology domain SHE3 PF17078.5 CRG87068.1 - 0.18 11.5 2.6 1.1 8.9 2.6 1.9 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Methyltransf_23 PF13489.6 CRG87069.1 - 5.3e-19 68.6 0.0 7.9e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87069.1 - 1.6e-11 44.8 0.0 6.8e-11 42.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87069.1 - 1.7e-08 34.4 0.0 0.003 17.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87069.1 - 3.1e-08 34.1 0.0 7.9e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87069.1 - 6.7e-08 33.2 0.1 4e-07 30.7 0.0 2.4 2 1 0 2 2 1 1 Methyltransferase domain CMAS PF02353.20 CRG87069.1 - 0.0078 15.5 0.0 0.018 14.4 0.0 1.6 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CRG87069.1 - 0.014 14.8 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CRG87069.1 - 0.015 14.8 0.0 0.1 12.2 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_16 PF10294.9 CRG87069.1 - 0.035 13.9 0.0 0.057 13.2 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_4 PF02390.17 CRG87069.1 - 0.047 13.2 0.1 0.23 10.9 0.0 2.1 2 1 0 2 2 2 0 Putative methyltransferase Methyltransf_2 PF00891.18 CRG87069.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 CRG87069.1 - 0.11 11.8 0.0 0.93 8.8 0.0 2.1 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family p450 PF00067.22 CRG87070.1 - 2e-53 181.8 0.1 4.7e-53 180.6 0.1 1.5 2 0 0 2 2 2 1 Cytochrome P450 DUF2282 PF10048.9 CRG87071.1 - 1.4e-05 25.0 23.4 0.015 15.2 0.3 5.8 2 1 2 5 5 5 4 Predicted integral membrane protein (DUF2282) Con-6 PF10346.9 CRG87072.1 - 3.8e-27 94.0 4.1 5.7e-16 58.3 2.0 2.2 2 0 0 2 2 2 2 Conidiation protein 6 DUF3533 PF12051.8 CRG87073.1 - 1.3e-118 396.3 11.2 1.6e-118 395.9 11.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) Ndc1_Nup PF09531.10 CRG87073.1 - 0.12 11.0 5.1 0.19 10.3 5.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TauD PF02668.16 CRG87074.1 - 9.8e-51 173.1 0.0 1.2e-50 172.9 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ufm1 PF03671.14 CRG87075.1 - 0.18 11.9 0.4 0.18 11.9 0.4 2.4 2 2 0 2 2 2 0 Ubiquitin fold modifier 1 protein NmrA PF05368.13 CRG87076.1 - 5.3e-13 49.1 0.0 6.4e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG87076.1 - 1.9e-11 44.2 0.0 2.7e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Pro-kuma_activ PF09286.11 CRG87077.1 - 6.3e-39 133.5 1.0 2.1e-38 131.8 0.3 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG87077.1 - 1.3e-07 31.2 0.3 4.3e-07 29.5 0.1 2.0 2 1 0 2 2 2 1 Subtilase family Sugar_tr PF00083.24 CRG87078.1 - 4.5e-117 391.7 31.5 5.9e-117 391.3 31.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG87078.1 - 2.6e-23 82.5 45.2 2.4e-18 66.2 19.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ThiJ_like PF17124.5 CRG87079.1 - 7.1e-16 58.5 0.0 1e-15 58.0 0.0 1.2 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 CRG87079.1 - 6e-12 45.7 0.0 3.1e-11 43.3 0.0 2.2 1 1 0 1 1 1 1 DJ-1/PfpI family Flavokinase PF01687.17 CRG87079.1 - 0.11 12.8 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Riboflavin kinase adh_short PF00106.25 CRG87080.1 - 1.7e-10 40.7 0.1 7.3e-10 38.6 0.0 1.9 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG87080.1 - 0.0014 18.6 0.0 0.0037 17.2 0.0 1.7 1 0 0 1 1 1 1 KR domain MBOAT_2 PF13813.6 CRG87081.1 - 1.3e-20 73.4 2.3 4e-20 71.9 2.3 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family RIX1 PF08167.12 CRG87082.1 - 4.7e-65 218.9 3.5 6.2e-65 218.5 2.3 1.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis MSP1_C PF07462.11 CRG87082.1 - 0.11 11.2 3.5 0.17 10.6 3.5 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus TPR_14 PF13428.6 CRG87083.1 - 3.9e-12 45.9 13.4 0.023 15.5 0.0 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG87083.1 - 2.1e-07 30.6 0.7 1.5 9.2 0.0 6.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG87083.1 - 6.5e-07 29.0 5.2 1.2 9.4 0.0 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG87083.1 - 8.4e-06 26.2 4.7 0.086 13.4 0.0 5.3 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG87083.1 - 1.7e-05 24.5 2.0 0.12 12.3 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG87083.1 - 0.0054 17.0 1.4 59 4.4 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG87083.1 - 0.032 14.9 8.9 22 5.8 0.0 5.3 4 1 2 6 6 6 0 Tetratricopeptide repeat IFRD PF05004.13 CRG87083.1 - 0.033 13.3 0.0 0.087 11.9 0.0 1.7 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) TPR_7 PF13176.6 CRG87083.1 - 0.13 12.4 2.5 18 5.7 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat YscO PF07321.12 CRG87083.1 - 2.4 8.1 6.8 0.6 10.1 1.8 2.5 3 0 0 3 3 3 0 Type III secretion protein YscO NDUFA12 PF05071.16 CRG87084.1 - 9.1e-32 109.8 0.7 1.1e-31 109.5 0.7 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 PLDc_2 PF13091.6 CRG87085.1 - 4.8e-16 58.9 0.0 4.7e-09 36.2 0.0 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CRG87085.1 - 2.1e-09 37.2 0.4 0.00052 20.1 0.0 3.0 2 1 0 2 2 2 2 Phospholipase D Active site motif LTV PF04180.14 CRG87086.1 - 4.2e-121 405.3 19.7 4.9e-121 405.1 19.7 1.0 1 0 0 1 1 1 1 Low temperature viability protein MMR_HSR1 PF01926.23 CRG87087.1 - 3.3e-16 59.4 0.2 7.1e-14 51.9 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG87087.1 - 5.8e-07 29.2 0.2 6.3e-05 22.5 0.1 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CRG87087.1 - 1.5e-05 25.0 0.1 0.0066 16.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 CRG87087.1 - 0.00015 21.9 1.0 0.18 11.9 0.4 3.0 2 1 0 2 2 2 2 Dynamin family AIG1 PF04548.16 CRG87087.1 - 0.01 15.2 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 0 AIG1 family Glycos_transf_1 PF00534.20 CRG87088.1 - 6.1e-34 117.0 0.0 8.9e-34 116.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG87088.1 - 5.8e-30 104.5 0.0 1.1e-29 103.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CRG87088.1 - 2.6e-17 63.7 0.4 2.6e-17 63.7 0.4 2.2 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 CRG87088.1 - 1.5e-13 51.1 0.1 1e-12 48.4 0.1 2.1 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 CRG87088.1 - 9.6e-10 38.7 0.0 2.4e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3561 PF12084.8 CRG87088.1 - 0.026 14.5 0.7 0.053 13.5 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3561) CP12 PF02672.15 CRG87088.1 - 0.22 12.3 0.1 0.47 11.2 0.1 1.5 1 0 0 1 1 1 0 CP12 domain UDPG_MGDP_dh_N PF03721.14 CRG87089.1 - 1.1e-42 145.8 0.0 2.2e-40 138.2 0.0 3.0 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 CRG87089.1 - 5.6e-32 109.8 0.0 1e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 CRG87089.1 - 5.6e-21 74.9 0.0 2.2e-18 66.6 0.0 3.0 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.23 CRG87089.1 - 0.0061 16.5 0.2 1.9 8.4 0.1 3.0 2 1 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 CRG87089.1 - 0.014 15.3 0.0 0.045 13.6 0.0 1.9 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 CRG87089.1 - 0.025 14.7 0.2 3 7.9 0.1 3.3 3 1 0 3 3 3 0 lactate/malate dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CRG87089.1 - 0.044 13.9 0.0 1.1 9.4 0.0 2.6 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG87089.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 CRG87089.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Acyl-CoA_dh_1 PF00441.24 CRG87090.1 - 5e-31 108.0 0.9 8.6e-31 107.2 0.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CRG87090.1 - 5.1e-20 71.5 0.0 8.5e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CRG87090.1 - 1.3e-15 58.0 0.1 2.5e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CRG87090.1 - 1.8e-13 51.0 2.3 3e-13 50.2 2.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Spo12 PF05032.12 CRG87091.1 - 2.8e-15 55.9 3.9 5.2e-15 55.1 3.9 1.5 1 0 0 1 1 1 1 Spo12 family Acetyltransf_1 PF00583.25 CRG87092.1 - 2.3e-15 56.9 0.0 3.8e-07 30.3 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG87092.1 - 2.7e-13 50.1 0.0 2.4e-05 24.7 0.0 2.6 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG87092.1 - 2.9e-10 40.1 0.1 0.00039 20.4 0.0 2.6 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG87092.1 - 4.9e-06 26.6 0.0 0.029 14.5 0.0 3.2 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG87092.1 - 2.6e-05 24.3 0.1 0.36 11.0 0.0 2.3 2 0 0 2 2 2 2 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 CRG87092.1 - 0.0023 18.6 0.0 0.033 14.9 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG87092.1 - 0.0087 16.0 0.0 0.82 9.7 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Sad1_UNC PF07738.13 CRG87093.1 - 9.4e-31 106.6 0.0 1.7e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal KRAP_IP3R_bind PF14722.6 CRG87093.1 - 0.042 13.6 1.6 0.15 11.8 0.0 2.7 3 0 0 3 3 3 0 Ki-ras-induced actin-interacting protein-IP3R-interacting domain AAA_14 PF13173.6 CRG87093.1 - 0.23 11.5 1.1 0.5 10.4 1.1 1.5 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 CRG87094.1 - 1.5e-55 188.5 0.0 2.1e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87094.1 - 1.8e-34 119.2 0.0 2.7e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG87094.1 - 2.7e-11 43.3 0.0 3.7e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 CRG87094.1 - 0.031 13.6 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MR_MLE_C PF13378.6 CRG87095.1 - 6.6e-46 156.6 0.4 9.3e-46 156.1 0.4 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CRG87095.1 - 0.074 13.3 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain DHDPS PF00701.22 CRG87096.1 - 3.9e-37 127.5 0.0 4.5e-37 127.3 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Neur_chan_LBD PF02931.23 CRG87096.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain F-box-like_2 PF13013.6 CRG87097.1 - 0.071 13.1 0.0 0.11 12.5 0.0 1.5 1 1 0 1 1 1 0 F-box-like domain adh_short PF00106.25 CRG87098.1 - 1.8e-52 177.7 0.1 2.3e-52 177.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87098.1 - 2.3e-35 122.3 0.0 2.7e-35 122.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG87098.1 - 1.9e-12 47.5 0.0 2.4e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG87098.1 - 0.0011 18.1 0.1 0.0031 16.7 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CRG87098.1 - 0.0025 18.1 0.1 0.0056 16.9 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain RuvC PF02075.17 CRG87098.1 - 0.13 12.2 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 Crossover junction endodeoxyribonuclease RuvC Sugar_tr PF00083.24 CRG87099.1 - 2.7e-89 300.1 52.1 3.8e-85 286.5 24.1 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG87099.1 - 3.1e-58 197.4 71.5 2.8e-33 115.3 30.3 3.5 2 1 1 3 3 3 3 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG87099.1 - 3.1e-37 128.0 0.0 5.3e-37 127.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ada_Zn_binding PF02805.16 CRG87100.1 - 1.5e-27 95.4 6.7 3e-27 94.4 6.7 1.5 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 CRG87100.1 - 4.9e-08 32.9 0.0 1.1e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 CRG87100.1 - 2.9e-06 27.4 0.0 5.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain Ribosomal_L2_C PF03947.18 CRG87101.1 - 1.3e-40 138.5 4.7 1.3e-40 138.5 4.7 1.9 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 CRG87101.1 - 7.2e-14 51.5 0.1 1.5e-13 50.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Zn_clus PF00172.18 CRG87101.1 - 4.7e-10 39.4 9.4 8.1e-10 38.7 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WHIM1 PF15612.6 CRG87102.1 - 7e-06 25.4 0.0 1.7e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DUF1770 PF08589.10 CRG87103.1 - 1.3e-33 115.9 1.3 1.7e-33 115.5 1.3 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) PfkB PF00294.24 CRG87104.1 - 5e-71 239.5 0.2 6.2e-71 239.2 0.2 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 CRG87104.1 - 0.0019 17.6 0.0 0.0041 16.5 0.0 1.6 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase EST1_DNA_bind PF10373.9 CRG87105.1 - 6.6e-72 242.3 1.8 1.1e-70 238.3 0.3 2.3 2 0 0 2 2 2 2 Est1 DNA/RNA binding domain EST1 PF10374.9 CRG87105.1 - 3.7e-24 85.9 0.2 7.9e-23 81.6 0.1 2.6 2 0 0 2 2 2 1 Telomerase activating protein Est1 zf-C2H2 PF00096.26 CRG87106.1 - 0.015 15.7 0.7 0.015 15.7 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG87106.1 - 0.02 15.7 1.5 0.16 12.9 0.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Spt46 PF17734.1 CRG87106.1 - 0.068 13.0 0.9 0.23 11.2 0.1 2.1 2 1 0 2 2 2 0 Spermatogenesis-associated protein 46 Fungal_trans PF04082.18 CRG87107.1 - 1.1e-14 54.1 1.9 1.1e-14 54.1 1.9 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG87107.1 - 2.7e-11 43.3 10.4 6.8e-05 23.1 0.3 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG87107.1 - 5.4e-08 33.0 10.1 0.0039 17.9 3.8 3.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG87107.1 - 5.8e-08 32.8 2.4 5.8e-08 32.8 2.4 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CRG87107.1 - 5.6e-05 23.3 1.9 0.47 10.8 0.0 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CRG87107.1 - 0.017 15.1 9.2 1.7 8.8 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HE PF16278.5 CRG87107.1 - 0.023 15.1 2.1 0.023 15.1 2.1 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger gag_pre-integrs PF13976.6 CRG87107.1 - 0.058 13.3 4.7 0.1 12.4 1.4 2.6 1 1 1 2 2 2 0 GAG-pre-integrase domain zf-met PF12874.7 CRG87107.1 - 0.11 12.9 4.1 9.1 6.8 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 CRG87107.1 - 0.15 12.0 8.7 1.6 8.7 0.5 3.0 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_3rep PF18868.1 CRG87107.1 - 0.34 11.6 2.4 25 5.6 0.1 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-BED PF02892.15 CRG87107.1 - 3.4 7.8 6.2 8.7 6.5 2.8 2.4 1 1 1 2 2 2 0 BED zinc finger Pkinase PF00069.25 CRG87108.1 - 2.2e-68 230.5 0.0 5.8e-68 229.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87108.1 - 3.6e-47 160.8 0.0 6.7e-47 160.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 CRG87108.1 - 1.2e-26 92.9 0.0 2.2e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_1 PF00536.30 CRG87108.1 - 1.1e-15 57.8 0.1 2.2e-15 56.8 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 CRG87108.1 - 1.2e-12 47.7 0.1 3.1e-12 46.4 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 CRG87108.1 - 6.8e-09 35.5 0.0 2.9e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 Kinase-like RA PF00788.23 CRG87108.1 - 6.8e-06 26.6 0.0 1.2e-05 25.9 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Pkinase_fungal PF17667.1 CRG87108.1 - 0.0033 16.3 0.0 0.0059 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 CRG87108.1 - 0.011 15.1 0.0 0.037 13.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SAM_4 PF18017.1 CRG87108.1 - 0.11 12.5 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ribosomal_L5_C PF00673.21 CRG87109.1 - 4.4e-29 100.5 0.0 8.9e-29 99.5 0.0 1.5 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CRG87109.1 - 5.6e-06 26.6 0.0 1.1e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 UCH PF00443.29 CRG87110.1 - 3.8e-17 62.6 0.0 8.1e-17 61.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG87110.1 - 2.4e-16 60.2 0.0 8.6e-07 28.8 0.0 2.4 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pep3_Vps18 PF05131.14 CRG87111.1 - 6.2e-41 139.7 0.1 5.8e-40 136.5 0.0 2.5 3 0 0 3 3 3 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 CRG87111.1 - 3.3e-09 36.7 6.7 3e-07 30.4 0.1 3.1 3 1 0 3 3 3 2 Region in Clathrin and VPS zf-RING_5 PF14634.6 CRG87111.1 - 0.0012 18.7 0.2 0.0028 17.6 0.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 CRG87111.1 - 0.0017 18.1 0.4 0.0017 18.1 0.4 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CRG87111.1 - 0.0021 17.8 4.1 0.0061 16.3 4.1 1.8 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 CRG87111.1 - 0.0034 17.0 0.1 0.0066 16.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type DUF2175 PF09943.9 CRG87111.1 - 0.0065 16.7 0.2 0.63 10.4 0.0 2.8 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_2 PF13639.6 CRG87111.1 - 0.016 15.5 0.9 0.04 14.3 0.9 1.7 1 0 0 1 1 1 0 Ring finger domain RPN1_RPN2_N PF17781.1 CRG87111.1 - 0.016 14.6 0.0 0.038 13.4 0.0 1.5 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain Vps39_2 PF10367.9 CRG87111.1 - 0.066 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 SoxE PF06525.11 CRG87111.1 - 0.089 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Sulfocyanin (SoxE) domain zf-RING_UBOX PF13445.6 CRG87111.1 - 0.15 12.1 0.5 0.37 10.8 0.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3H2C3 PF17122.5 CRG87111.1 - 2.6 8.1 5.3 0.3 11.2 0.6 1.9 2 0 0 2 2 1 0 Zinc-finger BAR PF03114.18 CRG87112.1 - 9.4e-48 162.9 9.0 1.2e-47 162.6 9.0 1.1 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 CRG87112.1 - 0.0012 18.1 2.7 0.0015 17.8 2.7 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Ribosomal_S10 PF00338.22 CRG87112.1 - 0.05 13.8 0.1 0.21 11.9 0.0 2.0 1 1 1 2 2 2 0 Ribosomal protein S10p/S20e SNF2_N PF00176.23 CRG87113.1 - 2.5e-70 236.9 1.1 2.5e-70 236.9 1.1 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 CRG87113.1 - 2.7e-26 91.5 1.0 1.1e-25 89.5 0.8 2.2 1 1 1 2 2 2 1 Bromodomain Helicase_C PF00271.31 CRG87113.1 - 1.2e-18 67.5 0.0 1.2e-18 67.5 0.0 3.3 4 0 0 4 4 4 1 Helicase conserved C-terminal domain HSA PF07529.13 CRG87113.1 - 2.1e-17 63.2 17.2 2.1e-17 63.2 17.2 3.7 5 0 0 5 5 5 1 HSA SnAC PF14619.6 CRG87113.1 - 1.4e-14 54.5 1.2 1.4e-14 54.5 1.2 4.1 4 2 2 6 6 6 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 CRG87113.1 - 9.2e-12 44.5 0.5 9.2e-12 44.5 0.5 2.4 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 CRG87113.1 - 7.2e-10 39.1 0.0 7.2e-10 39.1 0.0 3.3 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DUF3303 PF11746.8 CRG87113.1 - 0.14 12.5 0.1 0.4 11.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3303) Alpha-amylase PF00128.24 CRG87114.1 - 1.1e-22 81.0 0.7 3.3e-20 72.9 0.5 3.2 2 1 0 2 2 2 1 Alpha amylase, catalytic domain Glyco_transf_5 PF08323.11 CRG87114.1 - 6.1e-14 52.3 0.1 1.1e-13 51.5 0.1 1.3 1 0 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 CRG87114.1 - 6.4e-05 22.5 0.0 0.00013 21.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 CRG87114.1 - 0.01 15.8 0.0 0.01 15.8 0.0 1.8 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CRG87114.1 - 0.013 15.9 0.0 0.035 14.6 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain CENP-B_dimeris PF09026.10 CRG87114.1 - 0.071 13.5 1.1 0.17 12.3 1.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Radial_spoke PF04712.12 CRG87114.1 - 3.7 6.4 11.3 2.3 7.1 6.8 2.4 3 0 0 3 3 3 0 Radial spokehead-like protein DNA_pol_phi PF04931.13 CRG87114.1 - 8.3 4.4 6.5 13 3.7 6.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Flavodoxin_1 PF00258.25 CRG87115.1 - 3.3e-34 118.1 0.0 6.8e-34 117.1 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 CRG87115.1 - 7.3e-27 94.4 0.0 1.2e-26 93.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CRG87115.1 - 1.1e-11 45.3 0.0 3e-11 43.9 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 CRG87115.1 - 0.0003 20.5 0.0 0.058 13.1 0.0 2.2 2 0 0 2 2 2 2 Flavodoxin domain Flavodoxin_5 PF12724.7 CRG87115.1 - 0.028 14.7 0.0 0.12 12.6 0.0 2.1 3 0 0 3 3 3 0 Flavodoxin domain RNA_pol_3_Rpc31 PF11705.8 CRG87116.1 - 6.3e-60 203.2 17.6 7.7e-60 203.0 17.6 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.12 CRG87116.1 - 1.3 8.4 14.6 1.6 8.1 14.6 1.2 1 0 0 1 1 1 0 SDA1 SnoaL_2 PF12680.7 CRG87117.1 - 0.024 15.3 0.1 0.029 15.0 0.1 1.2 1 0 0 1 1 1 0 SnoaL-like domain TPR_4 PF07721.14 CRG87117.1 - 0.11 13.2 0.1 0.81 10.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat JAB PF01398.21 CRG87119.1 - 2.9e-09 36.9 0.0 4.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CRG87119.1 - 1e-07 32.3 0.1 2.1e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Solute_trans_a PF03619.16 CRG87120.1 - 4.7e-88 295.1 25.1 5.6e-88 294.9 25.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha RSB_motif PF16294.5 CRG87121.1 - 7.9e-10 38.9 0.1 7.9e-10 38.9 0.1 5.0 2 1 3 5 5 5 1 RNSP1-SAP18 binding (RSB) motif SAP PF02037.27 CRG87121.1 - 1.8e-08 34.0 0.3 3.4e-08 33.1 0.3 1.5 1 0 0 1 1 1 1 SAP domain Abhydrolase_1 PF00561.20 CRG87122.1 - 1.8e-49 168.7 0.1 2.6e-49 168.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold ADH_zinc_N PF00107.26 CRG87122.1 - 4.2e-11 43.0 0.0 8.2e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG87122.1 - 2.1e-06 27.6 0.6 1.6e-05 24.7 0.3 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Abhydrolase_6 PF12697.7 CRG87122.1 - 0.00044 20.9 3.6 0.0013 19.4 3.6 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family ADH_N_2 PF16884.5 CRG87122.1 - 0.1 12.5 0.1 0.25 11.3 0.1 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase THOC2_N PF16134.5 CRG87123.1 - 4.8e-239 795.2 0.1 2.3e-238 793.0 0.0 2.1 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 CRG87123.1 - 7.4e-102 340.6 0.0 1.4e-101 339.7 0.0 1.5 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 CRG87123.1 - 7.5e-29 99.6 0.1 3.4e-28 97.5 0.0 2.1 2 0 0 2 2 2 1 Transcription- and export-related complex subunit Ank_2 PF12796.7 CRG87124.1 - 1.1e-55 186.2 0.9 1.8e-14 54.1 0.0 5.1 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 CRG87124.1 - 3e-48 160.2 0.4 1.1e-05 25.7 0.0 8.8 9 0 0 9 9 9 8 Ankyrin repeat Ank_3 PF13606.6 CRG87124.1 - 1.4e-42 138.8 0.2 1.8e-05 24.7 0.0 9.0 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 CRG87124.1 - 4.3e-40 135.6 1.0 1.5e-06 28.6 0.0 7.0 4 2 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG87124.1 - 8.9e-35 118.3 4.4 2.5e-07 30.8 0.0 7.7 1 1 7 8 8 8 8 Ankyrin repeats (many copies) DUF1279 PF06916.13 CRG87124.1 - 0.0074 16.8 0.0 1.5 9.4 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1279) Pro-kuma_activ PF09286.11 CRG87125.1 - 2.7e-18 66.6 0.0 4e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain FAD_binding_4 PF01565.23 CRG87126.1 - 0.043 13.5 0.0 0.043 13.5 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Ank_2 PF12796.7 CRG87127.1 - 1.5e-24 86.4 0.1 4.4e-11 43.2 0.1 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG87127.1 - 1.2e-11 44.8 0.0 8.4e-05 23.0 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG87127.1 - 3.9e-11 43.0 0.9 0.00015 22.0 0.1 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 CRG87127.1 - 6.7e-11 42.1 0.0 0.00018 21.8 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 CRG87127.1 - 7.9e-10 38.1 0.0 0.044 14.3 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat vWA-TerF-like PF10138.9 CRG87127.1 - 0.00038 20.6 0.0 0.00074 19.7 0.0 1.4 1 0 0 1 1 1 1 vWA found in TerF C terminus DUF4635 PF15466.6 CRG87127.1 - 0.042 13.4 1.1 0.09 12.3 0.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) MSA-2c PF12238.8 CRG87128.1 - 0.024 14.7 2.0 0.031 14.3 2.0 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c SOG2 PF10428.9 CRG87128.1 - 0.26 10.4 7.8 0.32 10.2 7.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MGC-24 PF05283.11 CRG87128.1 - 0.5 10.8 7.1 0.97 9.9 7.1 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Mucin PF01456.17 CRG87128.1 - 2.3 8.2 23.2 4.4 7.3 23.2 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Glyco_hydro_47 PF01532.20 CRG87129.1 - 1.1e-170 568.5 0.0 2.1e-170 567.6 0.0 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 47 RXLR PF16810.5 CRG87129.1 - 0.18 12.2 5.7 0.33 11.4 5.7 1.4 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity Dicty_REP PF05086.12 CRG87129.1 - 8.7 4.2 10.4 12 3.7 10.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Zn_clus PF00172.18 CRG87130.1 - 4.9e-06 26.6 7.7 9.2e-06 25.7 7.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG87130.1 - 0.0002 20.5 0.0 0.00037 19.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain APH PF01636.23 CRG87132.1 - 1.6e-11 44.6 0.0 2.4e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 CRG87132.1 - 2.4e-06 27.1 0.0 2.8e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 CRG87132.1 - 0.001 18.0 0.0 0.0012 17.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Ctr PF04145.15 CRG87133.1 - 1.2e-38 133.0 2.1 1.2e-38 133.0 2.1 2.1 2 0 0 2 2 2 1 Ctr copper transporter family Sugar_tr PF00083.24 CRG87133.1 - 8.2e-37 127.1 26.9 6.2e-27 94.6 3.1 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG87133.1 - 6.7e-22 77.9 28.7 6.7e-22 77.9 28.7 3.5 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_1 PF07690.16 CRG87134.1 - 1.4e-31 109.7 27.1 1.6e-30 106.3 27.9 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF5134 PF17197.4 CRG87135.1 - 0.48 10.3 6.1 0.046 13.6 1.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5134) Vps5 PF09325.10 CRG87136.1 - 1.9e-12 47.2 0.9 3e-12 46.6 0.9 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CRG87136.1 - 3.2e-07 30.3 0.0 5.5e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 PX domain DUF429 PF04250.13 CRG87136.1 - 0.036 13.8 0.1 0.073 12.9 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF429) GTP_EFTU PF00009.27 CRG87137.1 - 1.4e-55 187.9 0.0 2.3e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CRG87137.1 - 4.5e-27 93.9 0.0 1.5e-26 92.3 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_C PF00679.24 CRG87137.1 - 6.9e-17 61.3 0.0 5.4e-09 36.0 0.0 2.8 3 0 0 3 3 3 2 Elongation factor G C-terminus RF3_C PF16658.5 CRG87137.1 - 7.6e-06 25.8 0.0 1.7e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 CRG87137.1 - 8.5e-06 26.1 0.0 2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_IV PF03764.18 CRG87137.1 - 0.00051 19.8 0.1 0.011 15.5 0.0 2.4 2 0 0 2 2 2 1 Elongation factor G, domain IV ArfGap PF01412.18 CRG87138.1 - 2.7e-32 111.3 0.1 6.4e-32 110.1 0.1 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf RRM_1 PF00076.22 CRG87139.1 - 2.8e-31 107.2 0.3 9.5e-15 54.2 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG87139.1 - 2.3e-05 24.0 0.0 0.067 12.8 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG87139.1 - 0.00012 22.1 0.0 0.036 14.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif PHM7_cyt PF14703.6 CRG87139.1 - 0.00092 19.5 0.3 2.4 8.4 0.0 2.9 2 2 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter DbpA PF03880.15 CRG87139.1 - 0.054 13.5 0.1 14 5.8 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_Rrp7 PF17799.1 CRG87139.1 - 0.12 12.1 0.0 2.3 8.0 0.0 2.3 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain DUF4783 PF16022.5 CRG87139.1 - 0.17 12.1 0.0 1.8 8.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) FXMRP1_C_core PF12235.8 CRG87139.1 - 0.27 11.9 10.2 0.62 10.7 10.2 1.6 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal DUF2985 PF11204.8 CRG87140.1 - 6.6e-22 77.5 4.0 1.2e-21 76.6 4.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2985) DUF4560 PF15118.6 CRG87140.1 - 0.32 10.9 1.3 0.64 10.0 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4560) DHR10 PF18595.1 CRG87141.1 - 0.0082 16.2 5.7 0.0082 16.2 5.7 2.6 2 0 0 2 2 2 1 Designed helical repeat protein 10 domain Cnn_1N PF07989.11 CRG87141.1 - 0.011 15.9 3.2 0.14 12.4 0.2 2.6 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 GAS PF13851.6 CRG87141.1 - 0.11 11.8 12.1 0.05 12.9 1.9 2.4 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding PKcGMP_CC PF16808.5 CRG87141.1 - 0.14 12.0 4.6 0.33 10.8 4.6 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Fez1 PF06818.15 CRG87141.1 - 0.19 12.2 7.2 0.098 13.1 1.2 2.5 2 0 0 2 2 2 0 Fez1 KLRAQ PF10205.9 CRG87141.1 - 0.34 11.2 4.7 0.34 11.2 0.7 2.5 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein Fungal_TACC PF12709.7 CRG87141.1 - 0.83 10.1 6.3 3.5 8.1 0.3 2.8 3 0 0 3 3 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins MCC-bdg_PDZ PF10506.9 CRG87141.1 - 2 8.5 6.3 16 5.6 0.2 2.5 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome YabA PF06156.13 CRG87141.1 - 2.4 8.9 6.9 4.3 8.0 0.8 2.6 2 0 0 2 2 2 0 Initiation control protein YabA Golgin_A5 PF09787.9 CRG87141.1 - 3.7 6.9 9.2 23 4.3 9.2 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 5 SHE3 PF17078.5 CRG87141.1 - 5 6.8 9.7 1.1 8.9 1.6 2.3 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 SlyX PF04102.12 CRG87141.1 - 5.1 7.8 6.6 0.65 10.7 0.1 2.8 3 0 0 3 3 3 0 SlyX ABC_tran_CTD PF16326.5 CRG87141.1 - 8.8 6.7 9.3 0.89 9.8 1.6 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain VASt PF16016.5 CRG87142.1 - 9.8e-36 123.5 0.0 1.9e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 CRG87142.1 - 5.3e-21 74.6 0.0 9.6e-21 73.8 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DNA_pol_phi PF04931.13 CRG87142.1 - 8.9 4.3 6.5 14 3.6 6.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi Glyco_hydro_3_C PF01915.22 CRG87143.1 - 4.1e-54 183.6 0.0 6.6e-54 183.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CRG87143.1 - 5.9e-23 80.8 3.6 1.2e-22 79.7 0.6 2.3 2 0 0 2 2 2 1 Fibronectin type III-like domain Glyco_hydro_3 PF00933.21 CRG87143.1 - 8.3e-07 28.7 0.0 0.00056 19.4 0.0 3.0 1 1 1 2 2 2 2 Glycosyl hydrolase family 3 N terminal domain Sugar-bind PF04198.13 CRG87143.1 - 0.022 13.9 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 Putative sugar-binding domain RraA-like PF03737.15 CRG87143.1 - 0.052 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Aldolase/RraA Glyco_hydro_12 PF01670.16 CRG87144.1 - 2.9e-48 164.7 13.0 3.3e-48 164.5 13.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 PMM PF03332.13 CRG87144.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic phosphomannomutase Phage_holin_5_1 PF06946.11 CRG87144.1 - 0.57 10.6 4.4 0.42 11.0 0.7 2.4 1 1 1 2 2 2 0 Bacteriophage A118-like holin, Hol118 WD40 PF00400.32 CRG87146.1 - 2.2e-13 50.5 16.4 0.00051 20.8 0.4 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87146.1 - 9.3e-05 22.7 0.0 0.1 12.9 0.1 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain GCIP PF13324.6 CRG87146.1 - 0.063 12.9 2.3 0.095 12.3 2.3 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Ge1_WD40 PF16529.5 CRG87146.1 - 0.087 11.8 0.0 0.48 9.3 0.0 2.1 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cwf_Cwc_15 PF04889.12 CRG87146.1 - 0.52 10.0 18.5 0.025 14.3 12.3 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein UQ_con PF00179.26 CRG87147.1 - 1e-42 145.1 0.0 1.7e-42 144.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Cyclin_C_2 PF16899.5 CRG87147.1 - 4.6e-36 123.3 0.1 7.8e-32 109.8 0.0 2.8 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 CRG87147.1 - 0.00011 22.0 0.0 0.00021 21.0 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain UBA_3 PF09288.10 CRG87147.1 - 0.00027 20.7 0.0 0.00055 19.7 0.0 1.5 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain AAA PF00004.29 CRG87148.1 - 5.2e-41 140.2 0.0 1e-40 139.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG87148.1 - 1.8e-11 43.6 0.3 4.1e-11 42.5 0.3 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 CRG87148.1 - 2.5e-10 40.1 0.2 5.1e-10 39.1 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 CRG87148.1 - 4.3e-06 27.0 0.2 0.039 14.2 0.1 2.7 1 1 1 2 2 2 2 AAA domain AAA_2 PF07724.14 CRG87148.1 - 1e-05 25.7 0.0 2.1e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 CRG87148.1 - 1.9e-05 23.9 0.0 3.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 CRG87148.1 - 5.4e-05 23.2 0.0 0.00016 21.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG87148.1 - 0.00052 20.4 0.4 0.013 15.9 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 CRG87148.1 - 0.00085 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CRG87148.1 - 0.016 15.7 0.0 0.045 14.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 CRG87148.1 - 0.018 14.3 0.1 0.04 13.1 0.1 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 CRG87148.1 - 0.019 15.2 1.1 0.038 14.2 0.0 2.1 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 CRG87148.1 - 0.019 14.7 0.0 0.045 13.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.6 CRG87148.1 - 0.023 14.9 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 CRG87148.1 - 0.027 14.3 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Prot_ATP_OB_N PF17758.1 CRG87148.1 - 0.028 14.1 1.0 0.082 12.6 0.0 2.2 2 0 0 2 2 2 0 Proteasomal ATPase OB N-terminal domain ATPase PF06745.13 CRG87148.1 - 0.028 13.7 0.2 0.44 9.8 0.1 2.3 1 1 0 2 2 2 0 KaiC PhoH PF02562.16 CRG87148.1 - 0.04 13.4 0.3 0.35 10.3 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 CRG87148.1 - 0.041 13.2 0.0 0.11 11.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 CRG87148.1 - 0.045 13.7 0.2 1 9.3 0.1 2.6 1 1 1 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 CRG87148.1 - 0.05 13.0 0.1 0.11 11.8 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 CRG87148.1 - 0.063 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CRG87148.1 - 0.066 13.6 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CRG87148.1 - 0.2 11.4 1.3 0.3 10.8 0.3 1.9 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CRG87148.1 - 0.22 11.0 0.1 0.5 9.9 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 CRG87148.1 - 2.5 7.6 5.8 1.8 8.1 0.3 2.9 2 1 0 3 3 3 0 AAA domain ABC_tran PF00005.27 CRG87149.1 - 1.9e-46 158.0 0.0 1.5e-22 80.6 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 CRG87149.1 - 3.2e-22 78.4 3.3 3.2e-22 78.4 3.3 2.8 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 CRG87149.1 - 7.5e-18 65.4 0.3 0.0011 18.8 0.0 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG87149.1 - 4.7e-10 39.3 0.4 0.004 16.6 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG87149.1 - 1.4e-09 38.8 1.7 0.011 16.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CRG87149.1 - 9.5e-09 34.9 0.0 0.0025 17.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG87149.1 - 6.8e-07 29.3 0.5 0.0045 16.9 0.0 3.0 3 0 0 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 CRG87149.1 - 9.1e-07 29.4 0.0 0.0083 16.5 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 CRG87149.1 - 9.4e-07 28.9 0.0 0.034 13.8 0.0 2.9 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 CRG87149.1 - 4.6e-06 26.7 0.1 0.022 14.8 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 CRG87149.1 - 6.7e-06 26.4 0.0 0.066 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CRG87149.1 - 7.1e-06 26.6 0.1 0.049 14.2 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 CRG87149.1 - 3.1e-05 24.4 0.0 0.37 11.2 0.0 3.1 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CRG87149.1 - 3.4e-05 24.2 1.0 1.2 9.5 0.0 3.5 3 0 0 3 3 3 2 RNA helicase AAA_28 PF13521.6 CRG87149.1 - 3.5e-05 24.1 0.0 0.014 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 CRG87149.1 - 8e-05 22.6 0.2 0.11 12.4 0.0 2.4 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.6 CRG87149.1 - 9e-05 22.7 0.6 0.44 10.7 0.1 3.3 4 0 0 4 4 2 2 AAA domain AAA_5 PF07728.14 CRG87149.1 - 0.00013 22.0 0.1 0.82 9.7 0.1 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Roc PF08477.13 CRG87149.1 - 0.00043 20.5 0.0 2.2 8.5 0.0 3.1 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 CRG87149.1 - 0.00052 19.7 0.4 0.19 11.3 0.0 2.7 3 0 0 3 3 2 1 AAA domain Dynamin_N PF00350.23 CRG87149.1 - 0.00092 19.3 2.5 3.8 7.5 0.0 3.6 3 1 1 4 4 4 1 Dynamin family AAA_14 PF13173.6 CRG87149.1 - 0.001 19.1 0.0 2.2 8.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 CRG87149.1 - 0.0017 17.6 0.0 2.6 7.1 0.0 3.0 2 1 0 2 2 2 2 NB-ARC domain AAA_24 PF13479.6 CRG87149.1 - 0.0026 17.5 1.0 1.9 8.2 0.0 3.4 4 0 0 4 4 3 1 AAA domain AAA_7 PF12775.7 CRG87149.1 - 0.0097 15.4 0.0 0.91 9.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_30 PF13604.6 CRG87149.1 - 0.013 15.3 0.3 2 8.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 CRG87149.1 - 0.013 15.4 0.3 2.4 8.0 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 CRG87149.1 - 0.017 14.7 0.0 0.79 9.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain DUF2813 PF11398.8 CRG87149.1 - 0.019 14.2 0.4 5.7 6.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2813) DUF815 PF05673.13 CRG87149.1 - 0.029 13.5 0.0 2.7 7.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF87 PF01935.17 CRG87149.1 - 0.032 14.3 0.2 15 5.6 0.0 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain Ras PF00071.22 CRG87149.1 - 0.044 13.4 0.0 5.2 6.6 0.0 2.7 3 0 0 3 3 2 0 Ras family NTPase_1 PF03266.15 CRG87149.1 - 0.049 13.5 1.0 4 7.3 0.1 2.8 3 0 0 3 3 3 0 NTPase TsaE PF02367.17 CRG87149.1 - 0.068 13.2 0.7 22 5.1 0.0 3.2 3 1 1 4 4 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 CRG87149.1 - 0.069 13.1 0.0 15 5.5 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain UvsY PF11056.8 CRG87149.1 - 0.097 13.0 1.1 1.7 9.0 1.3 2.5 2 0 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY AAA_17 PF13207.6 CRG87149.1 - 0.099 13.1 0.0 22 5.5 0.0 3.0 3 0 0 3 3 2 0 AAA domain Phage_tail_2 PF06199.11 CRG87149.1 - 0.12 12.5 0.1 0.37 10.9 0.0 1.8 2 0 0 2 2 1 0 Phage tail tube protein PduV-EutP PF10662.9 CRG87149.1 - 0.12 12.1 0.5 5.8 6.7 0.0 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.18 CRG87149.1 - 0.14 11.7 1.1 14 5.2 0.1 3.1 4 0 0 4 4 3 0 Ferrous iron transport protein B DUF3584 PF12128.8 CRG87149.1 - 3.9 4.9 6.4 0.24 8.9 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) HPP PF04982.13 CRG87150.1 - 4.3e-40 136.7 9.7 4.3e-40 136.7 9.7 1.5 2 0 0 2 2 2 1 HPP family GFO_IDH_MocA PF01408.22 CRG87152.1 - 9.8e-25 87.7 0.0 1.7e-24 86.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG87152.1 - 3e-16 59.5 0.0 4.8e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 CRG87152.1 - 2.1e-05 25.2 0.0 3.7e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 CRG87152.1 - 0.0023 18.1 0.0 0.004 17.3 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus CoA_binding PF02629.19 CRG87152.1 - 0.13 12.9 0.0 0.33 11.7 0.0 1.7 1 0 0 1 1 1 0 CoA binding domain HGTP_anticodon PF03129.20 CRG87154.1 - 9.5e-24 83.4 0.1 2.3e-23 82.2 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain p450 PF00067.22 CRG87155.1 - 5.6e-69 233.1 0.0 7.3e-69 232.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 CRG87155.1 - 5.3e-26 91.5 0.0 9.8e-26 90.7 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 CRG87155.1 - 9.4e-26 90.8 0.2 1.4e-25 90.1 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 CRG87155.1 - 2.4e-12 47.4 0.0 1.9e-11 44.6 0.0 2.4 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Flavodoxin_NdrI PF07972.11 CRG87155.1 - 0.04 14.1 0.0 0.087 13.0 0.0 1.5 1 0 0 1 1 1 0 NrdI Flavodoxin like Flavodoxin_5 PF12724.7 CRG87155.1 - 0.056 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain FMN_red PF03358.15 CRG87155.1 - 0.074 12.8 0.1 1.5 8.5 0.0 2.7 2 1 1 3 3 3 0 NADPH-dependent FMN reductase BBE PF08031.12 CRG87155.1 - 0.14 12.3 0.0 0.39 10.8 0.0 1.7 1 0 0 1 1 1 0 Berberine and berberine like PhyH PF05721.13 CRG87157.1 - 8e-20 72.0 0.0 1.2e-19 71.4 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 CRG87157.1 - 0.12 11.2 0.0 0.19 10.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1479) Fungal_trans_2 PF11951.8 CRG87158.1 - 7e-30 104.1 9.3 7e-30 104.1 9.3 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Mac PF12464.8 CRG87159.1 - 6.5e-15 55.1 0.0 1.4e-14 54.0 0.0 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 CRG87159.1 - 5.6e-11 41.7 15.5 1e-10 40.9 4.0 3.5 4 0 0 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG87159.1 - 2.3e-10 40.0 8.4 3e-10 39.7 3.3 2.9 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase MARVEL PF01284.23 CRG87159.1 - 6.7e-08 32.7 8.8 1.3e-07 31.8 8.8 1.4 1 0 0 1 1 1 1 Membrane-associating domain Peptidase_M56 PF05569.11 CRG87159.1 - 0.033 13.4 0.0 0.064 12.4 0.0 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 TMEM223 PF14640.6 CRG87159.1 - 0.081 13.1 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 223 DUF805 PF05656.14 CRG87159.1 - 0.11 12.9 0.8 0.45 10.9 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF805) TPR_2 PF07719.17 CRG87160.1 - 1.3e-06 28.1 6.2 0.39 10.9 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CRG87160.1 - 7.1e-06 25.6 1.8 2.7 8.0 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 CRG87160.1 - 0.00033 21.3 1.8 0.71 10.6 0.3 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG87160.1 - 0.00063 19.6 1.0 2.1 8.6 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG87160.1 - 0.033 14.5 0.8 11 6.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Cu_amine_oxid PF01179.20 CRG87161.1 - 9e-161 535.4 0.0 1.1e-160 535.1 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 CRG87161.1 - 7e-21 74.5 0.6 7.1e-20 71.3 0.1 2.4 2 0 0 2 2 2 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 CRG87161.1 - 4.8e-12 46.0 0.0 8.2e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain CAF1 PF04857.20 CRG87162.1 - 6.8e-23 81.3 0.0 2.4e-10 40.1 0.0 2.2 2 0 0 2 2 2 2 CAF1 family ribonuclease NDUF_B12 PF08122.12 CRG87163.1 - 3.8e-25 87.7 1.6 5.6e-25 87.2 1.6 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family WD40 PF00400.32 CRG87164.1 - 6.7e-18 64.7 8.0 0.00088 20.1 0.0 7.8 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87164.1 - 0.00013 22.1 0.0 0.84 10.0 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG87164.1 - 0.0024 16.9 1.4 5.5 5.9 0.0 3.9 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 CRG87164.1 - 0.058 12.7 0.4 5 6.4 0.0 2.8 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal NTP_transferase PF00483.23 CRG87164.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase TruB_C PF09142.11 CRG87164.1 - 3.2 7.6 7.2 17 5.2 0.0 4.1 4 0 0 4 4 4 0 tRNA Pseudouridine synthase II, C terminal AMP-binding PF00501.28 CRG87165.1 - 3.6e-81 272.9 0.0 4.6e-81 272.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG87165.1 - 1.5e-15 57.9 0.4 3.4e-15 56.8 0.4 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CNH PF00780.22 CRG87166.1 - 3.7e-65 220.3 0.0 5.6e-65 219.7 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 CRG87166.1 - 1.1e-32 113.8 1.6 1.9e-32 113.0 1.6 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 CRG87166.1 - 3.4e-13 49.9 0.0 1.8e-12 47.5 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CRG87166.1 - 0.0035 17.8 0.0 0.015 15.8 0.0 2.1 2 0 0 2 2 2 1 PH domain PH_16 PF17838.1 CRG87166.1 - 0.09 12.6 0.0 14 5.6 0.0 2.4 2 0 0 2 2 2 0 PH domain PDZ_5 PF17817.1 CRG87166.1 - 0.095 13.0 0.0 0.28 11.5 0.0 1.7 1 0 0 1 1 1 0 PDZ domain adh_short_C2 PF13561.6 CRG87167.1 - 5.1e-39 134.2 0.8 1.3e-37 129.6 0.8 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87167.1 - 1.3e-28 99.8 2.1 5.5e-28 97.8 2.1 1.7 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87167.1 - 1.1e-07 31.9 1.1 2e-07 31.1 0.3 1.6 2 0 0 2 2 2 1 KR domain Shikimate_DH PF01488.20 CRG87167.1 - 0.16 12.0 0.2 0.32 11.1 0.2 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TraL PF07178.11 CRG87168.1 - 0.12 12.8 0.2 0.21 12.0 0.2 1.3 1 0 0 1 1 1 0 TraL protein NPR2 PF06218.11 CRG87168.1 - 0.27 9.9 0.0 0.43 9.3 0.0 1.2 1 0 0 1 1 1 0 Nitrogen permease regulator 2 RabGAP-TBC PF00566.18 CRG87169.1 - 5.1e-47 160.3 0.0 8.2e-47 159.6 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 CRG87169.1 - 0.00011 22.1 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 GRAM domain EF-hand_6 PF13405.6 CRG87169.1 - 0.011 15.6 0.1 0.076 13.0 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain Exo_endo_phos PF03372.23 CRG87170.1 - 0.00025 20.6 0.0 0.00047 19.8 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4444 PF14563.6 CRG87170.1 - 0.11 12.2 0.1 0.25 11.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4444) Zn_clus PF00172.18 CRG87172.1 - 9.2e-06 25.7 9.1 2.5e-05 24.3 9.1 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NmrA PF05368.13 CRG87173.1 - 1.5e-14 54.1 0.1 2.2e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG87173.1 - 8e-13 48.7 0.0 1.2e-12 48.1 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding DapB_N PF01113.20 CRG87173.1 - 0.0035 17.5 0.5 0.0073 16.4 0.2 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus Sacchrp_dh_NADP PF03435.18 CRG87173.1 - 0.0055 17.0 0.0 0.01 16.1 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 CRG87173.1 - 0.0072 16.2 0.0 0.017 15.1 0.0 1.7 2 0 0 2 2 2 1 KR domain 3Beta_HSD PF01073.19 CRG87173.1 - 0.02 13.9 0.1 0.029 13.4 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 CRG87173.1 - 0.041 13.9 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.22 CRG87173.1 - 0.12 13.2 0.1 0.21 12.4 0.1 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Polysacc_synt_2 PF02719.15 CRG87173.1 - 0.16 11.0 0.1 0.39 9.8 0.0 1.6 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein RTC PF01137.21 CRG87175.1 - 1.7e-49 168.0 0.0 2.3e-49 167.6 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase Cupin_2 PF07883.11 CRG87176.1 - 4.5e-08 32.7 0.7 6.2e-08 32.2 0.7 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CRG87176.1 - 0.00025 21.0 0.4 0.00032 20.6 0.4 1.1 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_7 PF12973.7 CRG87176.1 - 0.002 18.0 0.1 0.0029 17.5 0.1 1.2 1 0 0 1 1 1 1 ChrR Cupin-like domain Cupin_6 PF12852.7 CRG87176.1 - 0.0038 17.0 0.2 0.0045 16.7 0.2 1.1 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.22 CRG87176.1 - 0.019 14.5 0.1 0.025 14.2 0.1 1.2 1 0 0 1 1 1 0 Cupin DUF1772 PF08592.11 CRG87177.1 - 2.1e-05 24.8 0.0 3.1e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) BAR PF03114.18 CRG87179.1 - 1.1e-14 54.7 1.1 1.6e-14 54.2 1.1 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 CRG87179.1 - 4e-13 49.0 0.1 7.1e-13 48.2 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG87179.1 - 2.9e-12 46.0 0.1 5.3e-12 45.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 CRG87179.1 - 1.8e-09 37.1 0.1 1.1e-08 34.6 0.2 2.2 2 0 0 2 2 2 1 Variant SH3 domain DUF2439 PF10382.9 CRG87180.1 - 1.6e-28 98.8 0.2 3.1e-28 97.9 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) Mcp5_PH PF12814.7 CRG87181.1 - 1.9e-45 153.9 0.5 5.5e-45 152.4 0.1 2.0 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology Methyltransf_23 PF13489.6 CRG87181.1 - 1.4e-13 51.0 0.0 3.6e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87181.1 - 3.1e-05 24.5 0.0 0.00016 22.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87181.1 - 5e-05 24.0 0.0 0.00021 22.0 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain PH PF00169.29 CRG87181.1 - 0.00023 21.6 0.0 0.00068 20.1 0.0 1.8 1 0 0 1 1 1 1 PH domain Methyltransf_31 PF13847.6 CRG87181.1 - 0.0027 17.5 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87181.1 - 0.0086 16.8 0.0 0.068 13.9 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain zf-C3HC4_2 PF13923.6 CRG87182.1 - 2e-08 33.9 8.1 3.8e-08 33.0 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG87182.1 - 2.1e-08 33.9 6.1 3.8e-08 33.1 6.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG87182.1 - 1.8e-07 31.0 6.5 3.6e-07 30.1 6.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-CCCH PF00642.24 CRG87182.1 - 3.8e-07 29.9 1.6 7.8e-07 28.9 1.6 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.25 CRG87182.1 - 1.2e-06 28.3 11.3 2.1e-06 27.5 11.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG87182.1 - 9.9e-06 25.4 9.3 1.8e-05 24.6 9.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 CRG87182.1 - 1e-05 25.6 3.5 1.9e-05 24.7 3.5 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-RING_2 PF13639.6 CRG87182.1 - 2.1e-05 24.7 7.5 4.2e-05 23.8 7.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf_CCCH_4 PF18345.1 CRG87182.1 - 9.2e-05 22.4 4.9 0.0002 21.3 4.9 1.6 1 0 0 1 1 1 1 Zinc finger domain Prok-RING_4 PF14447.6 CRG87182.1 - 0.0003 20.6 6.8 0.00059 19.6 6.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CRG87182.1 - 0.002 18.2 9.0 0.0045 17.1 9.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Opi1 PF08618.10 CRG87182.1 - 0.059 12.6 4.9 0.1 11.8 4.9 1.4 1 0 0 1 1 1 0 Transcription factor Opi1 zf-Nse PF11789.8 CRG87182.1 - 0.25 11.2 2.3 0.45 10.4 2.3 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 CRG87182.1 - 0.26 11.6 4.7 0.7 10.2 4.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain Ku PF02735.16 CRG87183.1 - 4.9e-43 147.2 0.0 1e-42 146.1 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 CRG87183.1 - 9.1e-34 117.1 0.1 1.4e-33 116.5 0.1 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 CRG87183.1 - 2.2e-26 92.4 3.0 2.2e-26 92.4 3.0 2.1 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 CRG87183.1 - 5.3e-11 42.0 0.1 1e-10 41.1 0.1 1.5 1 0 0 1 1 1 1 SAP domain Fungal_trans PF04082.18 CRG87184.1 - 3.5e-30 105.0 0.3 5.1e-30 104.4 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87184.1 - 2.2e-05 24.5 11.3 2.2e-05 24.5 11.3 2.2 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG87185.1 - 3.2e-33 115.1 27.7 3.2e-33 115.1 27.7 2.4 1 1 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG87185.1 - 2.3e-06 27.2 17.6 2.4e-06 27.1 2.4 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB AXE1 PF05448.12 CRG87185.1 - 0.17 10.5 0.0 0.35 9.5 0.0 1.4 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Hydrolase_4 PF12146.8 CRG87185.1 - 0.21 10.9 0.0 0.51 9.5 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 UPF0060 PF02694.15 CRG87185.1 - 5.6 7.2 10.9 3 8.1 4.8 3.1 2 1 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family Peptidase_S9 PF00326.21 CRG87186.1 - 0.00018 21.0 0.4 0.0025 17.3 0.4 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family UPF0227 PF05728.12 CRG87186.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) BAAT_C PF08840.11 CRG87186.1 - 0.15 11.9 0.0 0.35 10.8 0.0 1.5 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Amidase PF01425.21 CRG87187.1 - 1.6e-70 238.3 0.0 4.8e-66 223.6 0.0 2.1 2 0 0 2 2 2 2 Amidase Glyco_hydro_98M PF08306.11 CRG87187.1 - 0.013 14.8 0.1 0.021 14.1 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 MFS_1 PF07690.16 CRG87188.1 - 4.1e-34 118.0 28.6 4.1e-34 118.0 28.6 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 CRG87188.1 - 0.51 10.6 0.0 0.51 10.6 0.0 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF1772) Ferrochelatase PF00762.19 CRG87189.1 - 2.9e-94 315.7 0.0 7.2e-94 314.4 0.0 1.7 2 0 0 2 2 2 1 Ferrochelatase MFS_1 PF07690.16 CRG87189.1 - 6.2e-22 78.0 27.6 1.7e-18 66.7 6.9 3.1 2 1 0 3 3 3 2 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG87189.1 - 4.5e-09 35.7 1.0 8.9e-09 34.8 1.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ATG22 PF11700.8 CRG87189.1 - 0.2 10.2 26.4 0.0089 14.7 0.9 3.1 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like UPF0542 PF15086.6 CRG87189.1 - 2.6 8.0 8.4 13 5.8 0.5 3.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 PPR PF01535.20 CRG87190.1 - 0.0085 16.3 0.0 32 5.1 0.0 4.4 4 0 0 4 4 4 1 PPR repeat Phage_TAC_4 PF08748.11 CRG87190.1 - 0.018 15.4 0.2 6.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Phage tail assembly chaperone PPR_2 PF13041.6 CRG87190.1 - 0.067 13.4 0.0 3.4 7.9 0.0 3.5 4 0 0 4 4 4 0 PPR repeat family TPR_16 PF13432.6 CRG87190.1 - 0.24 12.1 1.7 6.8 7.4 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Nramp PF01566.18 CRG87191.1 - 2.3e-86 290.0 19.0 2.3e-86 290.0 19.0 2.0 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein VPDSG-CTERM PF18205.1 CRG87192.1 - 2.8 7.9 4.9 6.4 6.7 4.9 1.7 1 0 0 1 1 1 0 VPDSG-CTERM motif Chitin_synth_1 PF01644.17 CRG87193.1 - 1.9e-69 232.8 0.0 2.7e-69 232.3 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CRG87193.1 - 1.6e-26 92.0 0.1 4.4e-26 90.6 0.0 1.7 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CRG87193.1 - 1.6e-22 79.9 0.0 7.5e-19 67.7 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CRG87193.1 - 2.4e-08 34.1 0.1 2.4e-08 34.1 0.1 2.6 4 0 0 4 4 4 1 Glycosyl transferase family group 2 Fungal_trans PF04082.18 CRG87194.1 - 2.8e-08 33.1 0.1 6.2e-08 32.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain SE PF08491.10 CRG87195.1 - 2.6e-95 318.6 0.0 3.3e-95 318.3 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 CRG87195.1 - 6.8e-10 38.7 0.2 4.4e-09 36.0 0.2 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG87195.1 - 8.7e-09 35.4 0.3 2.9e-06 27.1 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 CRG87195.1 - 6.7e-06 25.4 1.7 2.3e-05 23.7 1.7 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CRG87195.1 - 7e-06 26.2 0.8 2.7e-05 24.3 0.9 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG87195.1 - 7e-05 22.0 0.9 0.00037 19.6 0.4 2.2 2 1 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG87195.1 - 7.5e-05 22.1 0.6 0.00019 20.8 0.3 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG87195.1 - 8.1e-05 21.9 1.4 8.1e-05 21.9 1.4 1.6 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 CRG87195.1 - 0.00022 20.7 0.4 0.00032 20.2 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG87195.1 - 0.001 18.3 0.0 0.002 17.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CRG87195.1 - 0.0012 17.7 0.3 0.0018 17.1 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein ApbA PF02558.16 CRG87195.1 - 0.0039 16.9 0.3 0.0075 15.9 0.3 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 CRG87195.1 - 0.0061 15.5 0.6 0.035 13.0 0.2 2.2 3 0 0 3 3 3 1 Tryptophan halogenase Pyr_redox PF00070.27 CRG87195.1 - 0.0076 16.8 0.4 0.026 15.1 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CRG87195.1 - 0.042 13.9 0.0 0.084 12.9 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.23 CRG87195.1 - 0.072 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.6 CRG87195.1 - 0.091 12.0 1.0 0.15 11.2 1.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 CRG87195.1 - 0.14 10.6 0.0 0.22 10.0 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor PAP_assoc PF03828.19 CRG87196.1 - 7.5e-18 64.5 0.1 1.9e-17 63.2 0.1 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase CALM_bind PF16025.5 CRG87197.1 - 0.41 11.1 7.2 1.2 9.7 7.2 1.8 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding SLC35F PF06027.12 CRG87198.1 - 3.6e-93 312.4 27.3 4.2e-93 312.1 27.3 1.0 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 CRG87198.1 - 5.5e-09 35.4 9.2 8.8e-09 34.7 9.2 1.4 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 CRG87198.1 - 2.7e-06 27.6 37.4 0.0049 17.0 13.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF2516 PF10724.9 CRG87198.1 - 4.2 7.7 16.4 0.99 9.7 3.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) SMK-1 PF04802.15 CRG87199.1 - 1.1e-80 269.9 1.0 2.3e-80 268.9 1.0 1.6 1 0 0 1 1 1 1 Component of IIS longevity pathway SMK-1 DCP1 PF06058.13 CRG87200.1 - 1.6e-30 105.4 0.0 2.8e-30 104.6 0.0 1.4 1 0 0 1 1 1 1 Dcp1-like decapping family SUIM_assoc PF16619.5 CRG87200.1 - 0.43 10.7 11.8 2.4 8.3 2.1 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Exo_endo_phos PF03372.23 CRG87201.1 - 4.4e-07 29.7 0.0 8.4e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Dyp_perox PF04261.12 CRG87201.1 - 0.011 14.8 0.7 0.019 14.0 0.7 1.3 1 0 0 1 1 1 0 Dyp-type peroxidase family CSN5_C PF18323.1 CRG87202.1 - 0.045 14.7 0.9 0.045 14.7 0.9 2.3 3 0 0 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain TolA_bind_tri PF16331.5 CRG87202.1 - 0.26 11.4 3.7 0.59 10.2 2.8 2.0 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF4525 PF15027.6 CRG87202.1 - 0.38 10.5 1.8 4.3 7.1 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4525) CorA PF01544.18 CRG87202.1 - 9 5.5 7.5 2.8 7.2 0.4 2.6 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein STE3 PF02076.15 CRG87203.1 - 1.5e-89 300.0 18.8 1.8e-89 299.8 18.8 1.0 1 0 0 1 1 1 1 Pheromone A receptor SSB PF00436.25 CRG87204.1 - 1e-15 57.6 0.0 1.4e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Single-strand binding protein family DUF4203 PF13886.6 CRG87205.1 - 7.4e-56 189.0 25.9 7.4e-56 189.0 25.9 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) Erf4 PF10256.9 CRG87205.1 - 2.4e-38 130.8 0.0 5e-38 129.8 0.0 1.6 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family Adap_comp_sub PF00928.21 CRG87206.1 - 3.2e-83 279.1 0.0 3.9e-83 278.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CRG87206.1 - 0.00015 21.7 0.2 0.00028 20.9 0.2 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 CRG87206.1 - 0.052 13.0 0.2 0.085 12.3 0.2 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain ORC6 PF05460.13 CRG87207.1 - 1.5 8.0 6.6 1.7 7.8 6.6 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) bVLRF1 PF18826.1 CRG87208.1 - 2.3e-64 215.8 0.7 6.3e-64 214.3 0.7 1.8 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Pkinase PF00069.25 CRG87208.1 - 1.9e-60 204.5 0.0 3.1e-60 203.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87208.1 - 1.6e-27 96.5 0.0 2.7e-27 95.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CRG87208.1 - 1.9e-06 28.1 0.0 4.1e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 FHA domain Ank_5 PF13857.6 CRG87208.1 - 3e-05 24.2 0.0 8.5e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Kdo PF06293.14 CRG87208.1 - 0.00044 19.7 0.1 0.001 18.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CRG87208.1 - 0.0013 17.6 0.0 0.0013 17.6 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Ank_4 PF13637.6 CRG87208.1 - 0.0033 18.0 0.0 0.0075 16.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) YrbL-PhoP_reg PF10707.9 CRG87208.1 - 0.0045 16.5 0.0 0.012 15.1 0.0 1.7 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Haspin_kinase PF12330.8 CRG87208.1 - 0.0063 15.5 0.1 0.01 14.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Ank_2 PF12796.7 CRG87208.1 - 0.034 14.7 0.0 0.097 13.3 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) APH PF01636.23 CRG87208.1 - 0.069 13.1 0.1 0.069 13.1 0.1 2.8 3 1 0 3 3 2 0 Phosphotransferase enzyme family zf-C2H2_2 PF12756.7 CRG87208.1 - 0.18 12.2 0.4 0.37 11.2 0.4 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DHDPS PF00701.22 CRG87209.1 - 5.9e-36 123.7 0.0 8.4e-36 123.2 0.0 1.2 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Fungal_trans_2 PF11951.8 CRG87210.1 - 2.2e-26 92.6 0.2 2.2e-26 92.6 0.2 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87210.1 - 7.2e-08 32.4 8.9 1.2e-07 31.8 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EPL1 PF10513.9 CRG87210.1 - 0.03 14.7 0.5 0.055 13.9 0.5 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like Band_3_cyto PF07565.13 CRG87210.1 - 0.12 12.1 1.2 6 6.6 0.4 2.3 2 0 0 2 2 2 0 Band 3 cytoplasmic domain DUF2841 PF11001.8 CRG87211.1 - 5.6e-46 155.6 0.0 8.8e-46 155.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) ABC_membrane PF00664.23 CRG87212.1 - 5.3e-84 282.1 26.4 3.4e-44 151.5 9.6 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG87212.1 - 8e-53 178.6 0.0 3.5e-30 105.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG87212.1 - 2.3e-10 40.3 3.6 0.0015 18.0 0.5 4.2 2 2 0 3 3 3 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CRG87212.1 - 3.9e-06 26.9 0.1 0.13 12.3 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG87212.1 - 4.3e-06 27.2 2.3 0.021 15.2 0.4 3.0 3 0 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 CRG87212.1 - 6.3e-05 22.6 0.1 0.35 10.6 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG87212.1 - 6.7e-05 22.9 0.1 0.016 15.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_23 PF13476.6 CRG87212.1 - 0.00046 20.7 0.0 0.048 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CRG87212.1 - 0.0015 18.4 0.1 0.61 9.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CRG87212.1 - 0.004 17.3 0.2 1.2 9.2 0.0 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_30 PF13604.6 CRG87212.1 - 0.0044 16.8 0.7 0.28 10.9 0.0 3.1 2 1 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CRG87212.1 - 0.0054 16.8 0.5 0.75 9.8 0.0 2.6 2 0 0 2 2 2 1 Dynamin family AAA_22 PF13401.6 CRG87212.1 - 0.011 16.0 0.5 2.5 8.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 CRG87212.1 - 0.016 14.9 0.3 0.94 9.1 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 CRG87212.1 - 0.078 13.2 0.0 14 5.9 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 CRG87212.1 - 0.094 12.0 0.0 9.1 5.5 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 CRG87212.1 - 0.15 12.5 0.0 6.9 7.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase DUF4748 PF15932.5 CRG87212.1 - 0.2 11.5 2.1 0.6 9.9 2.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) DUF4290 PF14123.6 CRG87212.1 - 0.23 11.0 1.7 0.8 9.2 1.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4290) AIG1 PF04548.16 CRG87212.1 - 0.35 10.2 1.0 7.8 5.8 0.0 2.4 2 0 0 2 2 2 0 AIG1 family NACHT PF05729.12 CRG87212.1 - 2.6 7.9 7.9 0.23 11.3 0.1 3.0 4 0 0 4 4 3 0 NACHT domain SAC3_GANP PF03399.16 CRG87213.1 - 1.9e-100 336.1 0.8 1.9e-100 336.1 0.8 1.5 2 0 0 2 2 2 1 SAC3/GANP family PfkB PF00294.24 CRG87213.1 - 7.9e-19 68.1 0.0 1.5e-18 67.2 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CN_hydrolase PF00795.22 CRG87214.1 - 1.1e-10 41.4 0.0 1.5e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HemeBinding_Shp PF11545.8 CRG87214.1 - 0.18 11.7 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Cell surface heme-binding protein Shp MFS_1 PF07690.16 CRG87215.1 - 2.6e-13 49.6 23.1 2.6e-13 49.6 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HLH PF00010.26 CRG87216.1 - 2.9e-13 49.6 2.0 5.2e-13 48.7 2.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Propeptide_C1 PF08127.13 CRG87216.1 - 0.034 14.0 0.3 0.11 12.4 0.3 1.8 1 0 0 1 1 1 0 Peptidase family C1 propeptide HU-CCDC81_bac_2 PF18175.1 CRG87216.1 - 0.085 12.7 0.1 0.25 11.2 0.0 1.8 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 ABC_membrane PF00664.23 CRG87217.1 - 1.4e-61 208.5 36.2 1.3e-36 126.6 18.2 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CRG87217.1 - 2.7e-48 163.9 0.1 3.4e-29 102.1 0.0 3.0 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG87217.1 - 7.2e-06 25.6 3.3 0.6 9.5 0.2 4.4 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CRG87217.1 - 1.3e-05 25.3 1.0 0.026 14.6 0.1 3.3 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_21 PF13304.6 CRG87217.1 - 2.7e-05 24.1 4.1 1.2 8.8 0.6 4.1 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CRG87217.1 - 0.00018 21.5 0.3 0.8 9.6 0.2 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 CRG87217.1 - 0.00019 21.1 0.1 0.19 11.5 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain Dimer_Tnp_hAT PF05699.14 CRG87217.1 - 0.0017 18.1 0.0 0.0043 16.8 0.0 1.7 1 0 0 1 1 1 1 hAT family C-terminal dimerisation region AAA_22 PF13401.6 CRG87217.1 - 0.0018 18.6 0.3 0.9 9.8 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CRG87217.1 - 0.0031 17.9 3.7 0.19 12.1 0.1 2.8 3 0 0 3 3 2 1 AAA ATPase domain Dynamin_N PF00350.23 CRG87217.1 - 0.0071 16.4 6.9 6.1 6.9 0.4 4.4 4 0 0 4 4 4 0 Dynamin family Zeta_toxin PF06414.12 CRG87217.1 - 0.017 14.4 0.1 4.1 6.6 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 CRG87217.1 - 0.023 15.2 17.7 0.43 11.1 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA_30 PF13604.6 CRG87217.1 - 0.025 14.3 2.2 5.3 6.7 0.2 2.7 2 1 0 2 2 2 0 AAA domain MeaB PF03308.16 CRG87217.1 - 0.025 13.5 0.3 1 8.2 0.0 2.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NB-ARC PF00931.22 CRG87217.1 - 0.027 13.7 0.2 3.3 6.8 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain TrwB_AAD_bind PF10412.9 CRG87217.1 - 0.036 13.0 0.3 1.5 7.7 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain T2SSE PF00437.20 CRG87217.1 - 0.049 12.7 0.0 6.7 5.7 0.1 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CRG87217.1 - 0.075 12.4 0.0 1.5 8.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 CRG87217.1 - 0.093 12.2 0.1 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 CRG87217.1 - 0.15 12.7 0.1 20 5.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CRG87217.1 - 0.19 11.3 3.2 1.7 8.2 0.2 2.8 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 CRG87217.1 - 0.39 10.5 3.7 16 5.1 0.0 3.4 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 CRG87217.1 - 0.5 10.4 0.0 0.5 10.4 0.0 3.1 2 1 1 3 3 3 0 Helicase HerA, central domain DUF4366 PF14283.6 CRG87217.1 - 0.78 9.8 8.6 0.22 11.5 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Na_trans_assoc PF06512.13 CRG87217.1 - 0.82 9.9 14.6 0.16 12.2 6.5 2.3 2 0 0 2 2 2 0 Sodium ion transport-associated GTP_EFTU PF00009.27 CRG87217.1 - 1.4 8.5 5.5 13 5.2 0.0 3.7 4 0 0 4 4 4 0 Elongation factor Tu GTP binding domain DUF3464 PF11947.8 CRG87217.1 - 3.2 7.5 10.8 2.4 7.9 0.0 3.1 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 RNA_pol_Rpc4 PF05132.14 CRG87217.1 - 3.5 8.1 10.1 8.8 6.8 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF2201_N PF13203.6 CRG87217.1 - 6 6.4 6.2 3.4 7.2 1.3 2.2 2 0 0 2 2 2 0 Putative metallopeptidase domain DUF4337 PF14235.6 CRG87217.1 - 6.1 6.9 6.2 11 6.1 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Connexin PF00029.19 CRG87217.1 - 7 6.3 5.6 5.1 6.8 0.3 2.5 2 0 0 2 2 2 0 Connexin Fungal_trans PF04082.18 CRG87218.1 - 1.7e-05 24.0 0.0 3.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cutinase PF01083.22 CRG87219.1 - 3.1e-47 160.8 1.6 3.7e-47 160.6 1.6 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CRG87219.1 - 0.0019 17.8 0.2 0.0029 17.2 0.2 1.2 1 0 0 1 1 1 1 PE-PPE domain VirJ PF06057.11 CRG87219.1 - 0.03 14.2 0.0 0.045 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) DUF2545 PF10810.8 CRG87219.1 - 0.082 13.1 0.2 0.29 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2545) AI-2E_transport PF01594.16 CRG87219.1 - 0.38 9.8 1.4 8.6 5.4 0.1 2.2 2 0 0 2 2 2 0 AI-2E family transporter DUF3405 PF11885.8 CRG87220.1 - 8.1e-172 572.4 3.9 1.1e-171 572.0 3.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Barwin PF00967.17 CRG87221.1 - 2.1e-09 37.2 0.1 3.9e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 Barwin family DPBB_1 PF03330.18 CRG87221.1 - 2.6e-05 24.4 0.2 0.00013 22.1 0.0 2.2 2 0 0 2 2 2 1 Lytic transglycolase Sec8_exocyst PF04048.14 CRG87222.1 - 2.8e-47 160.2 1.7 7.5e-47 158.8 1.7 1.8 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 CRG87222.1 - 1.6e-10 40.7 0.7 3.2e-10 39.8 0.7 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 CRG87222.1 - 9.5e-05 21.2 0.0 0.00016 20.4 0.0 1.3 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Dor1 PF04124.12 CRG87222.1 - 0.84 8.2 5.9 0.3 9.7 3.2 1.6 2 0 0 2 2 2 0 Dor1-like family Creatinase_N_2 PF16189.5 CRG87223.1 - 3.1e-53 180.2 0.1 6.8e-52 175.8 0.0 2.3 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 CRG87223.1 - 6.1e-43 146.9 0.0 8.4e-43 146.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 CRG87223.1 - 1.1e-21 77.9 0.0 7.3e-19 68.7 0.0 2.6 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 CRG87223.1 - 1.9e-20 72.7 0.3 5.1e-20 71.3 0.3 1.8 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 EST1_DNA_bind PF10373.9 CRG87224.1 - 1.3e-09 37.9 0.1 2.8e-08 33.6 0.1 2.4 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain F-box_5 PF18511.1 CRG87224.1 - 9.4 5.9 6.7 2.4 7.8 2.3 2.3 2 0 0 2 2 2 0 F-box Striatin PF08232.12 CRG87225.1 - 0.0068 17.0 0.6 0.0068 17.0 0.6 2.5 4 0 0 4 4 4 1 Striatin family Fez1 PF06818.15 CRG87225.1 - 0.076 13.5 0.4 0.13 12.7 0.4 1.2 1 0 0 1 1 1 0 Fez1 Tox-REase-3 PF15647.6 CRG87226.1 - 0.074 13.3 0.2 3.6 7.9 0.1 2.3 1 1 1 2 2 2 0 Restriction endonuclease fold toxin 3 GET2 PF08690.10 CRG87226.1 - 0.71 9.5 7.2 1.6 8.4 1.5 2.0 2 0 0 2 2 2 0 GET complex subunit GET2 DTHCT PF08070.11 CRG87226.1 - 1 10.2 11.5 5.9 7.7 1.6 2.5 2 0 0 2 2 2 0 DTHCT (NUC029) region FAM176 PF14851.6 CRG87226.1 - 1.3 8.7 3.7 9 5.9 0.6 2.2 2 0 0 2 2 2 0 FAM176 family Autophagy_N PF03986.13 CRG87227.1 - 1.6e-45 154.4 0.3 1.6e-45 154.4 0.3 1.5 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 CRG87227.1 - 2.9e-15 55.4 0.6 5.7e-15 54.5 0.6 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 CRG87227.1 - 2e-13 50.7 0.7 3.8e-13 49.8 0.7 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Cyclin_N PF00134.23 CRG87228.1 - 0.023 14.4 0.0 0.15 11.9 0.0 2.1 2 1 0 2 2 2 0 Cyclin, N-terminal domain TFIIB PF00382.19 CRG87228.1 - 0.041 13.9 0.0 0.35 11.0 0.0 2.3 3 0 0 3 3 3 0 Transcription factor TFIIB repeat ArgJ PF01960.18 CRG87229.1 - 6.9e-148 492.4 0.3 7.8e-148 492.2 0.3 1.0 1 0 0 1 1 1 1 ArgJ family SecY PF00344.20 CRG87230.1 - 5.4e-73 245.9 5.9 6.8e-73 245.6 5.9 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 CRG87230.1 - 2.4e-17 62.5 0.3 6.3e-17 61.1 0.3 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p MARVEL PF01284.23 CRG87230.1 - 0.43 10.6 0.1 0.43 10.6 0.1 3.1 2 1 0 2 2 2 0 Membrane-associating domain Promethin PF16015.5 CRG87231.1 - 7e-27 93.4 20.7 1e-26 92.9 20.7 1.3 1 0 0 1 1 1 1 Promethin DehI PF10778.9 CRG87231.1 - 0.24 11.5 1.1 0.27 11.4 0.2 1.5 2 0 0 2 2 2 0 Halocarboxylic acid dehydrogenase DehI TssN PF17555.2 CRG87231.1 - 2.6 7.3 5.7 3.3 7.0 5.7 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssN DUF1700 PF08006.11 CRG87231.1 - 3.5 7.1 9.5 4.9 6.6 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) MUG113 PF13455.6 CRG87232.1 - 4.5e-28 97.7 0.3 1e-27 96.6 0.3 1.6 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 CRG87232.1 - 6.6e-27 94.1 0.1 2e-26 92.5 0.1 1.8 1 0 0 1 1 1 1 T5orf172 domain ORC2 PF04084.14 CRG87233.1 - 3.6e-120 400.9 0.0 4.4e-120 400.6 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 FUN14 PF04930.15 CRG87234.1 - 1.8e-08 34.6 1.2 1.8e-08 34.6 1.2 1.6 2 0 0 2 2 2 1 FUN14 family DsbD PF02683.15 CRG87234.1 - 0.029 14.3 0.2 0.041 13.8 0.2 1.3 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region SOR_SNZ PF01680.17 CRG87235.1 - 1.5e-106 354.7 3.6 2.4e-106 354.1 3.6 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 CRG87235.1 - 1.8e-09 37.3 5.1 9.8e-07 28.3 0.3 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 CRG87235.1 - 0.0035 16.5 1.6 0.95 8.5 0.0 2.6 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.21 CRG87235.1 - 0.0052 16.0 0.0 0.53 9.4 0.0 2.3 2 0 0 2 2 2 2 Indole-3-glycerol phosphate synthase NanE PF04131.14 CRG87235.1 - 0.0067 15.6 0.6 0.23 10.6 0.0 2.5 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 CRG87235.1 - 0.043 13.3 1.5 0.89 9.0 0.0 2.6 2 1 0 2 2 2 0 Histidine biosynthesis protein NMO PF03060.15 CRG87235.1 - 0.065 12.6 6.8 0.46 9.8 0.4 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase IBN_N PF03810.19 CRG87236.1 - 1.2e-07 31.6 0.0 4.5e-07 29.7 0.0 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Importin_rep PF18773.1 CRG87236.1 - 0.0077 15.9 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Importin 13 repeat Importin_rep_3 PF18806.1 CRG87236.1 - 0.07 13.2 0.0 0.46 10.6 0.0 2.4 2 0 0 2 2 2 0 Importin 13 repeat GCIP PF13324.6 CRG87236.1 - 0.13 11.9 1.3 0.56 9.8 0.2 2.6 3 1 0 3 3 3 0 Grap2 and cyclin-D-interacting Sec7_N PF12783.7 CRG87236.1 - 0.71 9.8 3.2 0.75 9.7 0.4 2.5 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Glycos_transf_2 PF00535.26 CRG87237.1 - 1.9e-26 92.9 0.0 8.3e-26 90.8 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 CRG87237.1 - 1e-07 32.1 0.2 2.8e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 CRG87237.1 - 0.0038 16.7 0.0 0.0061 16.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 NUDIX PF00293.28 CRG87238.1 - 0.0003 20.8 0.0 0.00074 19.6 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain NUDIX PF00293.28 CRG87239.1 - 1.4e-16 60.7 0.0 3.6e-16 59.4 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain HAD_2 PF13419.6 CRG87240.1 - 2.6e-20 73.3 0.0 3.9e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG87240.1 - 7.2e-09 36.2 0.0 2.4e-08 34.5 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG87240.1 - 5.3e-06 26.4 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like NIF PF03031.18 CRG87240.1 - 1.5e-05 24.8 0.0 0.0012 18.7 0.0 2.2 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase Rit1_C PF17184.4 CRG87241.1 - 1.9e-101 339.1 0.0 2.3e-101 338.8 0.0 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 CRG87241.1 - 6.5e-37 126.2 0.0 1.3e-36 125.2 0.0 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain Aldo_ket_red PF00248.21 CRG87242.1 - 2e-41 142.1 0.0 6.2e-39 133.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family CH PF00307.31 CRG87243.1 - 2.1e-46 156.6 0.1 2.3e-22 79.2 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 CRG87243.1 - 2.3e-25 88.5 0.1 6.4e-25 87.0 0.1 1.9 1 0 0 1 1 1 1 Ca2+ insensitive EF hand RRM_1 PF00076.22 CRG87243.1 - 1e-16 60.5 0.0 2.9e-16 59.0 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CAMSAP_CH PF11971.8 CRG87243.1 - 6.5e-10 38.7 0.4 3.6e-06 26.7 0.1 2.6 2 0 0 2 2 2 2 CAMSAP CH domain FoP_duplication PF13865.6 CRG87243.1 - 7.1e-08 32.9 9.3 7.1e-08 32.9 9.3 4.2 4 0 0 4 4 4 1 C-terminal duplication domain of Friend of PRMT1 EF-hand_6 PF13405.6 CRG87243.1 - 0.00017 21.2 0.0 0.00089 19.0 0.0 2.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 CRG87243.1 - 0.00077 19.3 1.5 0.0021 17.9 0.1 2.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 CRG87243.1 - 0.00085 18.7 0.1 0.01 15.3 0.0 2.7 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CRG87243.1 - 0.023 15.1 2.2 0.11 12.9 0.5 3.1 2 0 0 2 2 2 0 EF-hand domain pair Spectrin PF00435.21 CRG87243.1 - 0.073 13.6 12.1 1.3 9.5 0.1 3.1 3 0 0 3 3 3 0 Spectrin repeat YqhG PF11079.8 CRG87243.1 - 0.12 11.4 2.2 0.25 10.3 1.9 1.7 2 0 0 2 2 2 0 Bacterial protein YqhG of unknown function Fib_alpha PF08702.10 CRG87243.1 - 0.16 12.1 0.3 6.2 7.0 0.0 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Cir_N PF10197.9 CRG87243.1 - 2.7 8.2 6.7 2 8.7 1.0 2.7 2 0 0 2 2 2 0 N-terminal domain of CBF1 interacting co-repressor CIR DUF4734 PF15881.5 CRG87243.1 - 2.8 8.1 4.6 7.9 6.7 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4734) WD40 PF00400.32 CRG87244.1 - 1.5e-23 82.6 5.2 1.4e-06 28.9 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87244.1 - 1.5e-08 34.8 0.3 0.26 11.6 0.1 4.4 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Me-amine-dh_H PF06433.11 CRG87244.1 - 0.00036 19.5 0.0 0.12 11.2 0.0 2.1 2 0 0 2 2 2 2 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.8 CRG87244.1 - 0.00058 18.6 0.0 0.5 8.9 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CRG87244.1 - 0.0093 15.0 0.0 0.94 8.4 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CRG87244.1 - 0.054 12.2 0.1 0.57 8.9 0.0 2.4 3 1 0 3 3 3 0 Nup133 N terminal like ABC_tran PF00005.27 CRG87245.1 - 7.8e-49 165.7 0.2 4.4e-28 98.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG87245.1 - 9.1e-31 107.5 27.7 1.5e-23 83.9 12.0 2.6 2 1 0 2 2 2 2 ABC transporter transmembrane region AAA_29 PF13555.6 CRG87245.1 - 2e-09 37.0 1.0 0.00019 21.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CRG87245.1 - 4.5e-09 36.5 3.0 0.01 15.7 0.0 4.1 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CRG87245.1 - 3.5e-07 30.6 0.2 0.027 14.7 0.1 3.1 2 1 0 2 2 2 2 AAA domain SMC_N PF02463.19 CRG87245.1 - 3.5e-07 29.9 0.8 0.069 12.6 0.0 4.2 4 0 0 4 4 4 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CRG87245.1 - 1.9e-06 27.9 0.5 0.08 12.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CRG87245.1 - 2.8e-06 28.0 0.4 0.014 15.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CRG87245.1 - 4e-06 26.1 0.2 0.039 13.0 0.1 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_33 PF13671.6 CRG87245.1 - 1.3e-05 25.4 0.5 0.3 11.2 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG87245.1 - 1.6e-05 25.4 0.3 0.097 13.1 0.0 3.1 2 0 0 2 2 2 2 AAA ATPase domain cobW PF02492.19 CRG87245.1 - 1.6e-05 24.6 1.6 0.059 12.9 0.1 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CRG87245.1 - 4.3e-05 23.2 0.0 0.2 11.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 CRG87245.1 - 7.6e-05 22.5 0.0 0.059 13.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 CRG87245.1 - 0.00013 21.2 0.5 0.027 13.6 0.0 2.8 2 1 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 CRG87245.1 - 0.00014 22.4 0.0 0.21 12.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain Dynamin_N PF00350.23 CRG87245.1 - 0.0002 21.4 0.4 0.015 15.4 0.0 2.4 2 0 0 2 2 2 1 Dynamin family AAA_7 PF12775.7 CRG87245.1 - 0.0004 20.0 0.2 1.2 8.6 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_30 PF13604.6 CRG87245.1 - 0.00049 19.9 1.7 1.6 8.4 0.8 3.2 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CRG87245.1 - 0.00068 19.7 0.6 1.8 8.7 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG87245.1 - 0.0022 17.6 0.2 0.41 10.2 0.0 2.7 3 0 0 3 3 2 1 Elongation factor Tu GTP binding domain TrwB_AAD_bind PF10412.9 CRG87245.1 - 0.0044 16.0 1.6 0.099 11.5 0.1 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Septin PF00735.18 CRG87245.1 - 0.0044 16.3 0.1 3 7.0 0.0 2.2 2 0 0 2 2 2 2 Septin AAA_15 PF13175.6 CRG87245.1 - 0.0052 16.6 0.1 2.1 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 CRG87245.1 - 0.0052 16.7 0.1 0.47 10.3 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 CRG87245.1 - 0.0055 17.1 0.0 3.5 7.9 0.0 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 CRG87245.1 - 0.0059 16.3 0.1 0.76 9.5 0.0 2.9 3 0 0 3 3 3 1 IstB-like ATP binding protein TsaE PF02367.17 CRG87245.1 - 0.0066 16.5 0.1 2.6 8.1 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SbcCD_C PF13558.6 CRG87245.1 - 0.0075 16.5 3.2 3.8 7.8 0.0 3.4 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.15 CRG87245.1 - 0.0085 16.0 2.7 0.41 10.5 0.1 2.7 3 0 0 3 3 2 1 NTPase Roc PF08477.13 CRG87245.1 - 0.011 15.9 0.3 1.5 9.0 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 CRG87245.1 - 0.011 16.1 0.0 9.3 6.7 0.0 3.0 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 CRG87245.1 - 0.013 15.5 2.2 2.3 8.1 0.0 2.9 3 0 0 3 3 2 0 NACHT domain PduV-EutP PF10662.9 CRG87245.1 - 0.014 15.2 0.9 6.3 6.5 0.0 3.1 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 CRG87245.1 - 0.014 14.7 0.6 1.9 7.8 0.2 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CRG87245.1 - 0.015 14.6 0.6 0.71 9.1 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin MobB PF03205.14 CRG87245.1 - 0.023 14.6 2.1 0.23 11.4 0.2 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_11 PF13086.6 CRG87245.1 - 0.029 14.2 0.1 6.5 6.4 0.0 2.6 3 0 0 3 3 2 0 AAA domain Pox_A32 PF04665.12 CRG87245.1 - 0.03 13.8 0.2 0.36 10.3 0.0 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein ABC_ATPase PF09818.9 CRG87245.1 - 0.037 12.8 1.8 0.26 10.1 0.1 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class ATP-synt_ab PF00006.25 CRG87245.1 - 0.047 13.3 0.1 6.8 6.3 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Viral_helicase1 PF01443.18 CRG87245.1 - 0.051 13.3 0.3 3.7 7.2 0.2 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase ATP_bind_1 PF03029.17 CRG87245.1 - 0.06 13.1 0.6 10 5.8 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein RNA_helicase PF00910.22 CRG87245.1 - 0.072 13.5 0.1 12 6.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase Rad17 PF03215.15 CRG87245.1 - 0.098 12.6 0.3 14 5.5 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_14 PF13173.6 CRG87245.1 - 0.12 12.4 0.1 6.9 6.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_28 PF13521.6 CRG87245.1 - 0.16 12.2 3.4 1 9.6 0.4 2.4 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 CRG87245.1 - 0.19 11.5 1.1 0.33 10.7 0.2 1.8 2 0 0 2 2 1 0 Phosphoribulokinase / Uridine kinase family Adeno_IVa2 PF02456.15 CRG87245.1 - 0.22 10.3 0.4 3.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein SRP54 PF00448.22 CRG87245.1 - 0.23 11.1 0.7 3.1 7.4 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain dNK PF01712.19 CRG87245.1 - 0.28 11.0 0.7 3.4 7.5 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_5 PF07728.14 CRG87245.1 - 0.42 10.6 1.4 34 4.4 0.1 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 CRG87245.1 - 0.71 9.9 2.0 4.9 7.2 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain PP-binding PF00550.25 CRG87246.1 - 0.054 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 Phosphopantetheine attachment site Metallophos PF00149.28 CRG87247.1 - 1.8e-35 123.3 0.1 3e-35 122.6 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 CRG87247.1 - 0.13 12.0 0.8 2.1 8.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) XylR_N PF06505.11 CRG87248.1 - 0.0072 16.0 0.0 0.024 14.4 0.0 1.8 2 0 0 2 2 2 1 Activator of aromatic catabolism Abhydrolase_2 PF02230.16 CRG87249.1 - 8.3e-13 48.6 0.0 3.3e-11 43.4 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase DUF3759 PF12585.8 CRG87250.1 - 2.5e-39 133.2 10.3 3e-39 132.9 10.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DUF4188 PF13826.6 CRG87251.1 - 1.1e-14 54.8 0.0 1.6e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) Herp-Cyclin PF09241.10 CRG87251.1 - 0.0071 17.0 0.1 6 7.6 0.0 2.3 2 0 0 2 2 2 2 Herpesviridae viral cyclin HNH_2 PF13391.6 CRG87252.1 - 0.00017 21.6 0.0 0.00044 20.3 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease UbiD PF01977.16 CRG87253.1 - 0.02 13.8 0.0 0.02 13.8 0.0 1.1 1 0 0 1 1 1 0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NmrA PF05368.13 CRG87254.1 - 2e-28 99.6 0.0 2.6e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG87254.1 - 4.9e-21 75.4 0.0 6.7e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG87254.1 - 4e-07 30.3 0.0 7.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CRG87254.1 - 5.6e-05 23.6 0.1 9.9e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 CRG87254.1 - 0.00057 20.0 0.0 0.0011 19.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase KR PF08659.10 CRG87254.1 - 0.00075 19.5 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG87254.1 - 0.0068 15.9 0.0 0.026 14.0 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CRG87254.1 - 0.015 15.4 0.1 0.025 14.7 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus F420_oxidored PF03807.17 CRG87254.1 - 0.021 15.4 0.2 0.044 14.4 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent adh_short PF00106.25 CRG87254.1 - 0.025 14.0 0.1 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase HTH_53 PF18606.1 CRG87254.1 - 0.049 13.3 0.0 2.4 7.9 0.0 2.6 2 1 1 3 3 3 0 Zap helix turn helix N-terminal domain Glyco_hydro_72 PF03198.14 CRG87255.1 - 2.3e-110 368.7 5.9 3.2e-110 368.3 5.9 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 CRG87255.1 - 6.5e-25 87.6 5.3 2.1e-24 86.0 5.3 2.0 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 CRG87255.1 - 0.00017 21.1 0.3 0.00048 19.7 0.2 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Meth_synt_2 PF01717.18 CRG87256.1 - 6.7e-144 479.1 0.0 3.2e-140 467.0 0.0 2.4 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 CRG87256.1 - 9.3e-118 393.3 0.0 1.2e-112 376.5 0.0 2.6 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 CRG87256.1 - 0.00018 20.8 0.0 0.016 14.4 0.0 2.5 2 0 0 2 2 2 2 Uroporphyrinogen decarboxylase (URO-D) ABC2_membrane PF01061.24 CRG87258.1 - 2.9e-75 252.3 59.6 6.7e-39 133.5 25.8 3.3 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 CRG87258.1 - 3.6e-35 121.4 0.0 8e-17 62.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CRG87258.1 - 1.5e-28 98.5 5.1 2.6e-24 84.9 0.0 3.6 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CRG87258.1 - 1.3e-14 54.6 0.1 7.1e-14 52.2 0.1 2.3 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_21 PF13304.6 CRG87258.1 - 2e-06 27.9 0.0 0.047 13.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 CRG87258.1 - 3.3e-06 26.5 40.6 0.0018 17.5 23.5 2.6 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 CRG87258.1 - 9.8e-05 22.8 0.3 0.032 14.6 0.1 2.9 3 0 0 3 3 2 1 AAA ATPase domain AAA_18 PF13238.6 CRG87258.1 - 0.0003 21.4 0.1 0.0056 17.2 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 CRG87258.1 - 0.00056 20.1 0.1 0.011 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CRG87258.1 - 0.00081 19.1 0.4 0.011 15.5 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG87258.1 - 0.001 19.0 0.1 0.005 16.8 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 CRG87258.1 - 0.0013 18.2 0.0 0.063 12.7 0.0 2.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 CRG87258.1 - 0.0025 17.4 0.5 0.019 14.6 0.2 2.3 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CRG87258.1 - 0.025 14.2 0.3 0.22 11.1 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 CRG87258.1 - 0.037 14.5 0.0 0.3 11.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain MbeD_MobD PF04899.12 CRG87258.1 - 0.041 14.0 1.7 0.13 12.4 1.7 1.9 1 0 0 1 1 1 0 MbeD/MobD like AAA_28 PF13521.6 CRG87258.1 - 0.048 13.9 0.2 0.2 11.9 0.2 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CRG87258.1 - 0.076 13.3 0.5 0.76 10.0 0.1 2.8 3 1 0 3 3 2 0 AAA domain AAA_30 PF13604.6 CRG87258.1 - 0.086 12.5 0.7 2.7 7.7 0.4 2.5 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CRG87258.1 - 0.17 11.6 0.3 8.5 6.1 0.1 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 CRG87258.1 - 0.21 11.7 0.2 12 6.0 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CRG87258.1 - 0.29 11.6 0.0 0.29 11.6 0.0 4.1 4 0 0 4 4 4 0 AAA domain KELK PF15796.5 CRG87258.1 - 1.3 9.6 7.3 0.63 10.5 0.3 2.6 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Halogen_Hydrol PF10112.9 CRG87258.1 - 7.4 6.5 8.7 4.6 7.2 0.0 3.4 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Glyco_hydro_71 PF03659.14 CRG87259.1 - 1e-132 442.5 0.6 1.5e-132 442.0 0.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Peptidase_M18 PF02127.15 CRG87260.1 - 4.7e-135 450.7 0.0 5.4e-135 450.5 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CRG87260.1 - 0.052 12.6 0.0 2.8 6.9 0.0 2.2 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase NOB1_Zn_bind PF08772.11 CRG87262.1 - 2.5e-32 110.8 4.6 4.7e-32 110.0 4.6 1.5 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 CRG87262.1 - 6.3e-31 106.7 0.4 1.7e-30 105.3 0.1 2.0 2 0 0 2 2 2 1 PIN domain of ribonuclease zinc_ribbon_15 PF17032.5 CRG87262.1 - 0.012 16.4 0.8 0.021 15.6 0.8 1.4 1 0 0 1 1 1 0 zinc-ribbon family DUF2321 PF10083.9 CRG87262.1 - 0.021 14.4 0.2 0.044 13.4 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) DZR PF12773.7 CRG87262.1 - 0.04 14.0 1.1 0.081 13.0 1.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-NADH-PPase PF09297.11 CRG87262.1 - 0.098 12.3 2.0 0.33 10.6 0.3 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain HypA PF01155.19 CRG87262.1 - 0.12 12.4 2.2 0.42 10.6 1.6 2.1 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 CRG87262.1 - 2.4 8.3 5.5 0.71 10.0 2.2 1.9 2 0 0 2 2 2 0 Zinc ribbon domain Nop10p PF04135.12 CRG87263.1 - 2.6e-22 78.6 1.2 3.1e-22 78.3 1.2 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family tRNA_int_endo PF01974.17 CRG87264.1 - 2e-17 63.0 0.2 6.2e-17 61.4 0.0 1.9 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 CRG87264.1 - 4.5e-06 26.3 0.0 0.042 13.5 0.0 2.4 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain Rad9_Rad53_bind PF08605.10 CRG87265.1 - 1.4e-20 73.8 0.0 2.3e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding Tudor_3 PF18115.1 CRG87265.1 - 8.7e-15 54.3 0.0 1.9e-14 53.2 0.0 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain BRCT_2 PF16589.5 CRG87265.1 - 1.5e-07 31.7 0.0 4.8e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CRG87265.1 - 1.3e-05 25.5 0.0 7.4e-05 23.0 0.0 2.4 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 CRG87265.1 - 0.0003 20.6 0.0 0.00069 19.4 0.0 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 CRG87265.1 - 0.0007 19.6 0.0 0.32 11.1 0.0 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Ribosomal_L27 PF01016.19 CRG87266.1 - 8.2e-31 105.9 0.1 1.6e-30 104.9 0.1 1.5 1 0 0 1 1 1 1 Ribosomal L27 protein Scramblase PF03803.15 CRG87267.1 - 7.3e-37 126.8 0.0 2e-35 122.1 0.0 2.3 1 1 0 1 1 1 1 Scramblase UQ_con PF00179.26 CRG87268.1 - 1.9e-48 163.7 0.0 2.2e-48 163.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TP6A_N PF04406.14 CRG87269.1 - 3.8e-21 74.8 0.0 7.2e-21 74.0 0.0 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase SQHop_cyclase_C PF13243.6 CRG87270.1 - 3.9e-48 164.2 0.1 2.6e-45 154.9 0.3 2.2 2 0 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 CRG87270.1 - 9.6e-44 149.6 2.8 1e-38 133.1 0.6 3.5 2 1 1 3 3 3 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 CRG87270.1 - 1.2e-31 108.1 5.7 2.1e-09 37.0 0.1 5.6 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Pec_lyase PF09492.10 CRG87270.1 - 1.3e-05 24.7 0.8 0.052 12.9 0.1 3.7 2 1 2 5 5 5 2 Pectic acid lyase TED_complement PF07678.14 CRG87270.1 - 2.4e-05 23.5 0.0 0.1 11.6 0.0 3.3 1 1 2 3 3 3 2 A-macroglobulin TED domain SGS PF05002.15 CRG87271.1 - 2.2e-29 101.4 7.7 1.1e-28 99.1 7.7 2.3 1 1 0 1 1 1 1 SGS domain CS PF04969.16 CRG87271.1 - 9.3e-16 58.6 2.2 1e-15 58.5 0.6 2.0 2 0 0 2 2 2 1 CS domain p450 PF00067.22 CRG87272.1 - 4.9e-41 140.9 0.0 7.3e-41 140.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 3Beta_HSD PF01073.19 CRG87273.1 - 1.9e-58 197.7 0.0 2.4e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG87273.1 - 2.2e-28 99.3 0.0 3.1e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG87273.1 - 6.2e-14 51.8 0.0 1.9e-11 43.7 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG87273.1 - 2.4e-13 50.2 0.0 1.4e-11 44.4 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG87273.1 - 2.6e-10 40.5 0.0 4.3e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CRG87273.1 - 1.7e-09 37.2 0.1 4.2e-09 35.9 0.1 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CRG87273.1 - 2e-08 33.8 0.0 6e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 CRG87273.1 - 9.2e-06 25.7 2.9 0.00034 20.6 2.9 2.7 1 1 0 1 1 1 1 KR domain NmrA PF05368.13 CRG87273.1 - 0.00067 19.3 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 CRG87273.1 - 0.0043 16.5 0.0 0.0094 15.4 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase TrkA_N PF02254.18 CRG87273.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Erg28 PF03694.13 CRG87274.1 - 8.4e-38 129.1 1.4 1.1e-37 128.8 1.4 1.1 1 0 0 1 1 1 1 Erg28 like protein p450 PF00067.22 CRG87275.1 - 8.9e-33 113.7 0.0 2.8e-31 108.8 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 MBOAT_2 PF13813.6 CRG87275.1 - 1e-15 57.7 0.4 2.5e-15 56.5 0.4 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family p450 PF00067.22 CRG87276.1 - 5.2e-41 140.9 0.0 6.4e-41 140.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 TNFR_16_TM PF18422.1 CRG87276.1 - 1.5 8.8 3.7 3.1 7.8 3.7 1.4 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain FAD_binding_4 PF01565.23 CRG87277.1 - 7.8e-22 77.5 0.7 1.5e-21 76.6 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG87277.1 - 0.029 14.5 0.0 0.095 12.8 0.0 2.0 1 0 0 1 1 1 0 Berberine and berberine like PQ-loop PF04193.14 CRG87278.1 - 6.8e-41 137.9 16.3 2.7e-22 78.3 1.3 2.7 3 0 0 3 3 3 2 PQ loop repeat DUF2157 PF09925.9 CRG87278.1 - 0.087 12.6 3.2 1.4 8.7 1.6 2.7 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) TAL_FSA PF00923.19 CRG87279.1 - 2.1e-46 158.6 0.0 2.4e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase tRNA-synt_1e PF01406.19 CRG87280.1 - 2.4e-113 378.5 0.0 4e-113 377.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 CRG87280.1 - 0.0002 20.2 0.7 0.55 8.9 0.1 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) DALR_2 PF09190.11 CRG87280.1 - 0.008 16.6 0.0 0.024 15.1 0.0 1.8 1 0 0 1 1 1 1 DALR domain GCD14 PF08704.10 CRG87281.1 - 9.7e-60 202.3 0.1 6.8e-57 193.0 0.1 3.1 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit TPR_2 PF07719.17 CRG87282.1 - 1.3e-06 28.0 0.2 0.033 14.3 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 CRG87282.1 - 5.4e-05 23.0 0.0 0.00014 21.7 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain TPR_16 PF13432.6 CRG87282.1 - 0.00087 19.9 0.0 0.021 15.4 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG87282.1 - 0.0041 17.4 0.1 0.067 13.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG87282.1 - 0.012 15.4 0.0 0.69 9.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DnaJ PF00226.31 CRG87282.1 - 0.029 14.5 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 DnaJ domain DUF1688 PF07958.11 CRG87283.1 - 8.4e-184 611.1 0.0 9.7e-184 610.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) DDT PF02791.17 CRG87283.1 - 0.16 12.3 0.0 2.5 8.5 0.1 2.3 1 1 1 2 2 2 0 DDT domain Gtr1_RagA PF04670.12 CRG87284.1 - 2e-92 308.7 0.1 2.4e-92 308.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 CRG87284.1 - 6.9e-09 35.4 0.0 1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 CRG87284.1 - 1.2e-08 35.2 0.0 2.2e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 CRG87284.1 - 5.2e-08 32.6 0.0 8.4e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CRG87284.1 - 4.2e-07 30.0 0.0 8.2e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 CRG87284.1 - 0.0019 17.4 3.2 0.39 9.8 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit GTP_EFTU PF00009.27 CRG87284.1 - 0.0093 15.5 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF815 PF05673.13 CRG87284.1 - 0.011 14.9 0.1 0.017 14.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 CRG87284.1 - 0.011 15.4 0.6 0.052 13.3 0.3 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CRG87284.1 - 0.013 16.1 0.0 0.026 15.0 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AIG1 PF04548.16 CRG87284.1 - 0.018 14.3 0.8 0.53 9.6 0.0 2.6 3 0 0 3 3 3 0 AIG1 family RsgA_GTPase PF03193.16 CRG87284.1 - 0.02 14.8 0.4 0.33 10.8 0.1 2.6 3 0 0 3 3 3 0 RsgA GTPase AAA_7 PF12775.7 CRG87284.1 - 0.049 13.1 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1_Xtn PF16897.5 CRG87284.1 - 0.071 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain adh_short PF00106.25 CRG87286.1 - 2.9e-13 49.7 0.0 9.2e-12 44.8 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase Fungal_trans PF04082.18 CRG87286.1 - 1.9e-12 46.8 0.4 3.6e-12 45.9 0.4 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_zinc_N_2 PF13602.6 CRG87286.1 - 3e-09 38.0 0.0 1.1e-08 36.3 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG87286.1 - 7.5e-09 35.5 0.0 1.5e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.6 CRG87286.1 - 4.2e-08 33.0 0.0 1.1e-07 31.7 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ADH_zinc_N PF00107.26 CRG87286.1 - 4e-06 26.8 0.0 1.4e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DUF4283 PF14111.6 CRG87286.1 - 0.025 14.1 0.0 0.051 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) PNP_UDP_1 PF01048.20 CRG87287.1 - 3.9e-15 55.7 0.0 1.1e-14 54.3 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily Fungal_trans PF04082.18 CRG87289.1 - 2.6e-25 89.0 0.4 3.8e-25 88.4 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cu_amine_oxid PF01179.20 CRG87289.1 - 0.048 12.6 0.1 0.072 12.0 0.1 1.2 1 0 0 1 1 1 0 Copper amine oxidase, enzyme domain DUF2400 PF09674.10 CRG87289.1 - 0.086 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) adh_short PF00106.25 CRG87290.1 - 4.4e-34 117.7 0.0 7.1e-34 117.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87290.1 - 3.4e-30 105.3 0.0 4.3e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 CRG87290.1 - 0.0036 17.2 0.1 0.0053 16.7 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CRG87290.1 - 0.031 14.8 0.2 0.087 13.4 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent KR PF08659.10 CRG87290.1 - 0.035 14.0 0.1 0.083 12.8 0.0 1.5 1 1 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 CRG87290.1 - 0.17 11.0 0.2 0.27 10.3 0.0 1.4 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DSBA PF01323.20 CRG87291.1 - 1.5e-21 77.0 0.0 1.7e-21 76.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Adap_comp_sub PF00928.21 CRG87292.1 - 6.7e-91 304.3 0.0 1.2e-90 303.5 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Ribonucleas_3_3 PF14622.6 CRG87292.1 - 1.5e-25 89.8 0.0 3.2e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Ribonuclease-III-like Clat_adaptor_s PF01217.20 CRG87292.1 - 4.6e-09 36.3 0.3 7.3e-09 35.7 0.3 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ribonuclease_3 PF00636.26 CRG87292.1 - 3.8e-05 24.2 0.0 0.0018 18.9 0.0 2.5 2 0 0 2 2 2 1 Ribonuclease III domain Sdh_cyt PF01127.22 CRG87293.1 - 2e-23 82.7 4.6 2.7e-23 82.3 4.6 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Mg_trans_NIPA PF05653.14 CRG87293.1 - 0.03 13.4 0.9 0.038 13.1 0.9 1.1 1 0 0 1 1 1 0 Magnesium transporter NIPA Pex14_N PF04695.13 CRG87293.1 - 0.43 11.2 3.1 0.67 10.6 3.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hap4_Hap_bind PF10297.9 CRG87294.1 - 2.2e-07 30.8 6.7 6.6e-07 29.3 6.7 1.9 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 CRG87294.1 - 3.3e-06 27.1 11.4 0.00019 21.4 10.4 2.5 1 1 1 2 2 2 1 bZIP transcription factor Striatin PF08232.12 CRG87294.1 - 0.015 15.9 3.1 0.015 15.9 3.1 1.8 1 1 0 1 1 1 0 Striatin family dsrm PF00035.26 CRG87294.1 - 0.11 13.2 0.0 0.29 11.9 0.0 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding motif Jnk-SapK_ap_N PF09744.9 CRG87294.1 - 0.18 12.0 7.4 0.37 11.0 7.4 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Filament PF00038.21 CRG87294.1 - 0.23 11.0 9.2 0.044 13.4 5.9 1.4 2 0 0 2 2 2 0 Intermediate filament protein V_ATPase_I PF01496.19 CRG87294.1 - 0.46 8.4 2.1 0.57 8.0 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_2 PF07716.15 CRG87294.1 - 3.9 7.6 17.4 1.7 8.8 11.2 3.0 2 1 1 3 3 3 0 Basic region leucine zipper Ribosomal_L19 PF01245.20 CRG87295.1 - 2.3e-15 56.5 0.3 4.1e-15 55.7 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L19 ZNRF_3_ecto PF18212.1 CRG87296.1 - 0.088 12.8 0.4 11 6.0 0.0 3.0 2 1 1 3 3 3 0 ZNRF-3 Ectodomain PhageMin_Tail PF10145.9 CRG87296.1 - 5.7 6.7 9.0 1.2 9.0 1.0 2.4 2 1 0 2 2 2 0 Phage-related minor tail protein AMP-binding PF00501.28 CRG87297.1 - 7.6e-07 28.1 0.1 0.0019 16.9 0.1 2.1 2 0 0 2 2 2 2 AMP-binding enzyme NPCC PF08058.11 CRG87298.1 - 2.9e-23 82.3 0.0 4.2e-23 81.8 0.0 1.2 1 0 0 1 1 1 1 Nuclear pore complex component Hid1 PF12722.7 CRG87299.1 - 0 1078.9 0.0 0 1078.7 0.0 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 CRG87299.1 - 1.5e-96 324.2 0.0 1.9e-96 324.0 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein NR_Repeat PF14046.6 CRG87299.1 - 0.15 12.2 0.3 0.39 10.9 0.3 1.6 1 0 0 1 1 1 0 Nuclear receptor repeat BC10 PF06726.12 CRG87299.1 - 0.19 12.0 2.5 0.43 10.9 0.1 2.9 3 0 0 3 3 3 0 Bladder cancer-related protein BC10 ABC_membrane_3 PF13748.6 CRG87299.1 - 6.1 6.0 5.7 2.7 7.1 0.3 2.1 2 0 0 2 2 2 0 ABC transporter transmembrane region HAT_KAT11 PF08214.11 CRG87300.1 - 1.2e-105 353.7 0.0 1.6e-105 353.3 0.0 1.1 1 0 0 1 1 1 1 Histone acetylation protein Glyco_transf_21 PF13506.6 CRG87301.1 - 9.9e-13 47.9 0.1 2e-05 24.1 0.0 3.7 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 CRG87301.1 - 5.5e-12 46.1 0.0 1.5e-11 44.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CRG87301.1 - 1.3e-06 28.3 0.0 0.04 13.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 DUF4381 PF14316.6 CRG87301.1 - 0.043 14.0 0.5 0.15 12.3 0.5 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) MgtC PF02308.16 CRG87301.1 - 4.7 7.6 6.7 26 5.2 1.5 2.3 2 0 0 2 2 2 0 MgtC family Ank_4 PF13637.6 CRG87302.1 - 1.4e-13 51.0 0.9 2.2e-07 31.3 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG87302.1 - 2e-12 47.5 0.2 1.6e-11 44.6 0.3 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG87302.1 - 2.5e-10 40.4 1.0 3.4e-08 33.6 0.5 3.4 3 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG87302.1 - 1.3e-09 37.5 0.2 2.5e-06 27.4 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 CRG87302.1 - 2.2e-09 37.3 0.2 1.4e-06 28.5 0.2 3.5 3 0 0 3 3 3 1 Ankyrin repeat WW PF00397.26 CRG87303.1 - 5.8e-10 39.1 1.7 1.2e-09 38.0 1.7 1.6 1 0 0 1 1 1 1 WW domain NMO PF03060.15 CRG87304.1 - 3.1e-55 187.9 1.0 2.9e-54 184.7 1.0 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CRG87304.1 - 6.1e-11 41.9 0.0 3.8e-10 39.3 0.0 1.9 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CRG87304.1 - 0.00017 20.8 0.3 0.0013 17.8 0.1 2.0 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 CRG87304.1 - 0.046 13.2 0.0 0.095 12.2 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein Glu_synthase PF01645.17 CRG87304.1 - 0.051 12.7 0.2 0.15 11.1 0.4 1.8 2 1 0 2 2 2 0 Conserved region in glutamate synthase FAD_binding_3 PF01494.19 CRG87305.1 - 4.5e-20 72.2 0.0 1.1e-19 70.9 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG87305.1 - 1.1e-07 31.9 0.2 3.9e-07 30.2 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG87305.1 - 3.2e-05 23.3 0.5 0.0047 16.2 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG87305.1 - 4.7e-05 23.1 2.7 8.2e-05 22.3 2.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG87305.1 - 0.00086 18.5 0.2 0.27 10.3 0.3 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Amino_oxidase PF01593.24 CRG87305.1 - 0.003 16.9 0.0 0.45 9.7 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 CRG87305.1 - 0.0039 16.5 0.5 0.02 14.2 0.5 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG87305.1 - 0.0048 16.2 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CRG87305.1 - 0.015 15.8 0.9 0.05 14.2 0.9 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG87305.1 - 0.04 13.0 2.1 0.059 12.4 2.1 1.2 1 0 0 1 1 1 0 FAD binding domain DUF4148 PF13663.6 CRG87305.1 - 0.047 13.9 0.2 0.2 11.9 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4148) DUF2204 PF09970.9 CRG87305.1 - 0.09 12.4 0.0 16 5.1 0.0 2.2 2 0 0 2 2 2 0 Nucleotidyl transferase of unknown function (DUF2204) GIDA PF01134.22 CRG87305.1 - 0.098 11.7 1.8 0.14 11.2 0.8 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 CRG87305.1 - 0.13 10.9 0.0 0.22 10.2 0.0 1.4 1 1 0 1 1 1 0 HI0933-like protein ApbA PF02558.16 CRG87305.1 - 0.21 11.2 0.4 0.65 9.6 0.5 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Methyltransf_2 PF00891.18 CRG87306.1 - 2.4e-20 72.8 0.0 7.2e-20 71.2 0.0 1.7 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_23 PF13489.6 CRG87306.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 CRG87307.1 - 2.9e-25 88.9 51.0 4.4e-19 68.6 32.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Deltameth_res PF16020.5 CRG87307.1 - 0.0076 16.1 6.8 0.078 12.9 0.1 3.6 3 0 0 3 3 3 2 Deltamethrin resistance ketoacyl-synt PF00109.26 CRG87308.1 - 1.9e-73 247.2 0.1 3.5e-73 246.3 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 CRG87308.1 - 1e-67 228.6 0.1 3.6e-67 226.8 0.0 1.9 2 0 0 2 2 2 1 AMP-binding enzyme Condensation PF00668.20 CRG87308.1 - 3.9e-51 174.2 0.0 8e-51 173.1 0.0 1.4 1 0 0 1 1 1 1 Condensation domain KR PF08659.10 CRG87308.1 - 1.9e-49 168.0 0.0 2.5e-47 161.1 0.0 2.4 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 CRG87308.1 - 6.8e-47 160.1 0.0 1.2e-46 159.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG87308.1 - 2.7e-44 151.9 0.0 5.7e-44 150.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG87308.1 - 1.5e-30 105.7 0.0 4.4e-30 104.1 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 CRG87308.1 - 1.1e-27 96.9 0.0 8.9e-27 93.9 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein Methyltransf_12 PF08242.12 CRG87308.1 - 7.7e-17 61.9 0.0 3.8e-16 59.7 0.0 2.3 2 0 0 2 2 1 1 Methyltransferase domain PP-binding PF00550.25 CRG87308.1 - 1.9e-15 57.0 1.0 1.4e-07 31.7 0.1 2.7 2 0 0 2 2 2 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CRG87308.1 - 8.5e-13 48.7 0.0 2.1e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_25 PF13649.6 CRG87308.1 - 9.2e-13 48.7 0.0 3.1e-12 47.0 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CRG87308.1 - 3e-12 46.5 0.0 4.6e-10 39.4 0.0 2.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 CRG87308.1 - 2.3e-10 40.6 0.0 5.1e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87308.1 - 4.4e-10 40.1 0.0 1.8e-09 38.1 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain adh_short PF00106.25 CRG87308.1 - 9.1e-09 35.1 0.0 4.1e-08 32.9 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CRG87308.1 - 2e-08 34.2 0.0 4.5e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG87308.1 - 2.1e-06 27.2 0.0 4.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family 3Beta_HSD PF01073.19 CRG87308.1 - 8.7e-06 24.9 0.0 0.00011 21.4 0.0 2.2 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 CRG87308.1 - 0.00046 19.6 0.0 0.00094 18.6 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain SAT PF16073.5 CRG87308.1 - 0.003 17.3 0.2 0.55 9.9 0.2 2.4 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_16 PF10294.9 CRG87308.1 - 0.02 14.7 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase NmrA PF05368.13 CRG87308.1 - 0.079 12.5 0.1 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 NmrA-like family ACP_syn_III PF08545.10 CRG87308.1 - 0.24 11.3 0.9 1.1 9.2 0.9 2.2 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Mito_carr PF00153.27 CRG87309.1 - 2.1e-09 37.2 4.3 0.006 16.5 0.0 5.0 4 1 0 4 4 4 3 Mitochondrial carrier protein Fer2 PF00111.27 CRG87310.1 - 1.2e-13 50.8 0.4 1.7e-13 50.3 0.4 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain YcgR_2 PF12945.7 CRG87310.1 - 0.039 14.1 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 Flagellar protein YcgR Rrp15p PF07890.12 CRG87311.1 - 3.1e-38 131.1 14.3 3.1e-38 131.1 14.3 2.6 2 1 0 2 2 2 1 Rrp15p DUF3295 PF11702.8 CRG87311.1 - 0.89 8.8 27.8 1.2 8.4 27.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) SRP54 PF00448.22 CRG87312.1 - 2.2e-74 249.3 2.9 4.6e-74 248.3 2.9 1.6 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 CRG87312.1 - 2.9e-29 101.6 0.5 2.9e-29 101.6 0.5 4.4 4 1 1 5 5 4 1 Signal peptide binding domain SRP54_N PF02881.19 CRG87312.1 - 1.6e-21 76.3 0.8 9.3e-21 73.8 1.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain cobW PF02492.19 CRG87312.1 - 4.1e-07 29.8 0.5 1.2e-06 28.2 0.5 1.8 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 CRG87312.1 - 7.8e-06 26.3 0.1 3.2e-05 24.4 0.1 2.1 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG87312.1 - 9.2e-06 26.1 0.0 2.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 CRG87312.1 - 2.2e-05 24.6 0.2 6.9e-05 23.0 0.1 2.0 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 CRG87312.1 - 9.4e-05 21.5 1.9 0.0009 18.3 0.4 2.9 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 CRG87312.1 - 0.001 19.1 0.0 0.0027 17.8 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 CRG87312.1 - 0.0011 18.7 0.3 0.0038 17.0 0.3 2.0 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CRG87312.1 - 0.002 18.0 0.0 0.0054 16.6 0.0 1.8 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.6 CRG87312.1 - 0.0028 17.9 0.0 0.015 15.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CRG87312.1 - 0.0029 17.7 0.2 0.042 13.9 0.1 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CRG87312.1 - 0.0036 16.6 0.0 0.0036 16.6 0.0 2.7 3 0 0 3 3 2 1 Zeta toxin ATP_bind_1 PF03029.17 CRG87312.1 - 0.0052 16.6 0.5 0.015 15.1 0.1 2.0 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 CRG87312.1 - 0.0056 16.1 1.0 2.6 7.4 0.1 3.0 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit ResIII PF04851.15 CRG87312.1 - 0.0059 16.6 1.1 0.22 11.5 0.1 2.6 2 1 1 3 3 2 1 Type III restriction enzyme, res subunit MobB PF03205.14 CRG87312.1 - 0.0068 16.3 0.2 0.033 14.1 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B Thymidylate_kin PF02223.17 CRG87312.1 - 0.0083 15.8 0.1 0.028 14.1 0.1 1.9 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 CRG87312.1 - 0.0084 16.4 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG87312.1 - 0.0099 16.4 0.3 0.027 15.0 0.1 2.0 2 1 0 2 2 1 1 AAA domain 6PF2K PF01591.18 CRG87312.1 - 0.0099 15.2 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_31 PF13614.6 CRG87312.1 - 0.041 13.8 0.3 0.24 11.3 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CRG87312.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ApbA PF02558.16 CRG87312.1 - 0.049 13.3 0.1 0.14 11.8 0.1 1.8 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Methyltransf_24 PF13578.6 CRG87312.1 - 0.074 14.1 0.0 0.18 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87312.1 - 0.087 13.5 1.0 5.2 7.8 0.0 3.2 3 0 0 3 3 3 0 Methyltransferase domain Arf PF00025.21 CRG87312.1 - 0.12 11.8 0.2 0.33 10.4 0.2 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family HAUS2 PF15003.6 CRG87312.1 - 0.13 12.0 1.4 0.13 12.0 0.1 1.7 2 0 0 2 2 1 0 HAUS augmin-like complex subunit 2 T3SS_needle_F PF09392.10 CRG87312.1 - 0.31 11.3 3.8 5.1 7.4 2.2 3.1 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Fez1 PF06818.15 CRG87313.1 - 1e-06 29.4 76.0 9.1e-05 23.0 18.1 4.4 1 1 3 4 4 4 4 Fez1 Anti-adapt_IraP PF10796.9 CRG87313.1 - 0.042 14.4 0.7 0.042 14.4 0.7 4.1 3 1 1 4 4 4 0 Sigma-S stabilisation anti-adaptor protein Filament PF00038.21 CRG87313.1 - 0.066 12.8 73.8 0.49 9.9 13.7 4.7 1 1 2 4 4 4 0 Intermediate filament protein PDZ_4 PF17816.1 CRG87313.1 - 0.26 11.7 1.7 0.56 10.6 0.1 2.5 2 0 0 2 2 2 0 PDZ domain IFT57 PF10498.9 CRG87313.1 - 0.59 9.0 62.5 0.13 11.3 8.0 4.8 2 2 2 5 5 5 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 CRG87313.1 - 1.6 7.5 79.2 1.4 7.7 7.2 4.5 1 1 3 5 5 5 0 Spc7 kinetochore protein Lebercilin PF15619.6 CRG87313.1 - 8.3 6.0 83.3 0.44 10.2 18.2 5.4 1 1 3 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease KGG PF10685.9 CRG87314.1 - 5.6e-18 64.6 24.3 4e-08 33.3 0.5 4.3 3 1 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif PhoD PF09423.10 CRG87315.1 - 1.6e-37 129.4 0.0 4.7e-37 127.8 0.0 1.6 1 1 0 1 1 1 1 PhoD-like phosphatase Glyco_hydro_18 PF00704.28 CRG87315.1 - 1e-11 45.1 0.0 1.8e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Pur_ac_phosph_N PF16656.5 CRG87315.1 - 6.6e-05 23.4 0.6 0.00019 21.9 0.6 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 CRG87315.1 - 0.0082 16.7 0.2 0.029 14.9 0.1 2.0 2 0 0 2 2 2 1 PhoD-like phosphatase, N-terminal domain p450 PF00067.22 CRG87316.1 - 6.1e-58 196.7 0.0 8.8e-58 196.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.8 CRG87316.1 - 5.9e-07 28.6 0.5 5.9e-07 28.6 0.5 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87316.1 - 0.0097 16.0 2.4 0.019 15.1 2.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_28 PF03033.20 CRG87317.1 - 6.7e-21 74.8 0.0 1.6e-20 73.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 CRG87317.1 - 0.0002 20.3 0.0 0.00073 18.4 0.0 1.7 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_hydro_10 PF00331.20 CRG87318.1 - 1.1e-71 241.7 0.0 1.2e-71 241.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.15 CRG87318.1 - 0.0083 15.5 0.1 0.018 14.4 0.1 1.4 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_1 PF00232.18 CRG87319.1 - 4.5e-108 361.6 3.0 6e-108 361.2 3.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_10 PF00331.20 CRG87319.1 - 0.12 11.6 0.0 1.3 8.1 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 10 Glyco_hydro_3_C PF01915.22 CRG87320.1 - 1.4e-49 168.9 0.0 2.4e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG87320.1 - 5.3e-40 137.7 0.0 9.5e-40 136.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG87320.1 - 1.2e-21 76.5 0.1 2.4e-21 75.6 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF2062 PF09835.9 CRG87321.1 - 0.032 14.1 3.0 0.051 13.4 3.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) ABC_cobalt PF09819.9 CRG87321.1 - 0.12 12.6 2.0 0.19 11.8 2.0 1.3 1 0 0 1 1 1 0 ABC-type cobalt transport system, permease component Abhydrolase_1 PF00561.20 CRG87322.1 - 6.7e-20 71.8 0.5 7.7e-20 71.6 0.5 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG87322.1 - 1.1e-12 49.1 0.1 1.8e-12 48.3 0.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG87322.1 - 1.1e-10 41.2 0.0 3e-08 33.2 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ndr PF03096.14 CRG87322.1 - 0.27 9.9 0.0 0.42 9.3 0.0 1.2 1 0 0 1 1 1 0 Ndr family Glyco_hydro_18 PF00704.28 CRG87323.1 - 3.2e-22 79.7 0.3 8e-22 78.4 0.3 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Collagen PF01391.18 CRG87323.1 - 1.9e-07 30.7 24.6 3.6e-07 29.9 24.6 1.4 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) COesterase PF00135.28 CRG87324.1 - 6.2e-86 289.3 0.1 1.4e-79 268.4 0.1 2.0 1 1 1 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG87324.1 - 1.7e-11 44.4 0.0 2.5e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Arylsulfotrans PF05935.11 CRG87325.1 - 4.4e-17 62.1 0.0 2.4e-07 30.0 0.1 3.2 1 1 1 3 3 3 2 Arylsulfotransferase (ASST) Arylsulfotran_2 PF14269.6 CRG87325.1 - 6.8e-17 61.8 0.0 1.1e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.6 CRG87325.1 - 1.8e-05 24.5 0.0 4.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 CRG87325.1 - 0.43 10.6 2.4 21 5.3 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat MFS_1 PF07690.16 CRG87326.1 - 1.4e-31 109.7 24.1 1.4e-31 109.7 24.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily WW PF00397.26 CRG87328.1 - 2.6e-08 33.8 3.1 5.2e-08 32.8 3.1 1.6 1 0 0 1 1 1 1 WW domain Remorin_C PF03763.13 CRG87328.1 - 0.012 15.5 0.2 0.02 14.7 0.2 1.3 1 0 0 1 1 1 0 Remorin, C-terminal region DUF2076 PF09849.9 CRG87328.1 - 0.031 14.3 5.4 0.038 14.0 5.4 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CoA_transf_3 PF02515.17 CRG87329.1 - 7.2e-67 226.1 0.0 9.7e-67 225.6 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III tRNA-synt_1b PF00579.25 CRG87330.1 - 4.2e-57 193.7 0.0 5.3e-57 193.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) IMPa_helical PF18642.1 CRG87330.1 - 0.0032 17.9 0.0 0.0067 16.8 0.0 1.4 1 0 0 1 1 1 1 Immunomodulating metalloprotease helical domain CAF1A PF12253.8 CRG87332.1 - 1.6e-22 79.5 3.8 1.6e-22 79.5 3.8 3.8 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A CAF-1_p150 PF11600.8 CRG87332.1 - 0.031 14.0 65.7 0.095 12.4 65.7 1.8 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal DUF262 PF03235.14 CRG87332.1 - 0.24 11.6 7.5 0.44 10.7 7.5 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF5401 PF17380.2 CRG87332.1 - 0.35 8.9 31.5 0.57 8.2 31.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CDC45 PF02724.14 CRG87332.1 - 4.9 5.3 33.4 0.088 11.1 23.3 2.1 2 0 0 2 2 2 0 CDC45-like protein AAA_11 PF13086.6 CRG87332.1 - 5.3 6.7 18.2 12 5.5 18.2 1.7 1 0 0 1 1 1 0 AAA domain IPP-2 PF04979.14 CRG87334.1 - 1.8e-18 67.5 26.6 2.2e-17 64.0 26.6 2.2 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) PI-PLC-C1 PF16670.5 CRG87335.1 - 2.8e-111 371.8 0.0 3.1e-111 371.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide phospholipase C, Ca2+-dependent DUF3859 PF12975.7 CRG87335.1 - 0.14 12.1 0.0 0.46 10.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3859) CRAL_TRIO PF00650.20 CRG87336.1 - 5.6e-17 61.9 0.0 8.9e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG87336.1 - 1.3e-08 34.9 0.0 3.3e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain TAF6_C PF07571.13 CRG87337.1 - 3.4e-30 104.2 0.0 1.1e-29 102.6 0.0 1.9 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 CRG87337.1 - 4.6e-26 90.8 0.0 1.1e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 CRG87337.1 - 0.0027 18.1 0.2 0.0062 16.9 0.1 1.6 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 CRG87337.1 - 0.0034 17.6 0.1 0.012 15.9 0.0 2.0 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CRG87337.1 - 0.0047 17.0 0.1 0.015 15.4 0.1 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit SAM_decarbox PF01536.16 CRG87338.1 - 1e-131 439.2 0.0 1.2e-131 439.0 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase TAFII28 PF04719.14 CRG87339.1 - 8.3e-26 89.9 1.3 4.3e-24 84.4 0.6 2.2 2 0 0 2 2 2 1 hTAFII28-like protein conserved region SRP-alpha_N PF04086.13 CRG87339.1 - 0.0037 17.2 1.1 0.0037 17.2 1.1 2.0 2 0 0 2 2 2 1 Signal recognition particle, alpha subunit, N-terminal Methyltrans_RNA PF04452.14 CRG87339.1 - 0.028 13.8 0.3 0.053 12.8 0.2 1.5 1 1 0 1 1 1 0 RNA methyltransferase PV-1 PF06637.11 CRG87339.1 - 0.21 10.4 1.9 0.29 9.9 1.9 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF572 PF04502.13 CRG87340.1 - 0.8 9.3 6.5 1.1 8.8 6.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Enkurin PF13864.6 CRG87340.1 - 1.7 9.1 7.9 6.4 7.3 7.0 2.4 2 1 0 2 2 2 0 Calmodulin-binding DRY_EERY PF09750.9 CRG87341.1 - 0.12 12.7 3.0 0.24 11.7 0.1 2.4 3 0 0 3 3 3 0 Alternative splicing regulator APG17 PF04108.12 CRG87342.1 - 0.01 15.0 0.3 0.012 14.7 0.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF3461 PF11944.8 CRG87342.1 - 0.031 14.4 1.7 0.049 13.8 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3461) EKLF_TAD1 PF16832.5 CRG87342.1 - 0.17 11.8 1.0 0.57 10.1 1.0 1.9 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 Fungal_trans PF04082.18 CRG87344.1 - 3e-14 52.7 0.2 4.9e-14 52.0 0.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87344.1 - 9.4e-07 28.9 11.9 1.7e-06 28.0 11.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 60KD_IMP PF02096.20 CRG87345.1 - 1.3e-17 64.2 1.0 1.3e-17 64.2 1.0 2.3 2 1 0 2 2 2 1 60Kd inner membrane protein UPF0242 PF06785.11 CRG87345.1 - 0.3 11.2 4.4 0.58 10.2 4.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TOM13 PF08219.11 CRG87346.1 - 2.1e-35 120.5 0.0 2.8e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 ParA PF10609.9 CRG87347.1 - 6.9e-87 291.0 0.1 1.3e-86 290.0 0.1 1.4 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase SEP PF08059.13 CRG87347.1 - 1.3e-22 80.1 0.0 3.2e-22 78.9 0.0 1.7 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 CRG87347.1 - 2.5e-12 46.4 0.1 5.1e-12 45.4 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 CRG87347.1 - 7.4e-12 45.3 0.0 1.6e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain CbiA PF01656.23 CRG87347.1 - 9e-10 38.7 0.0 3.3e-09 36.9 0.0 1.9 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 CRG87347.1 - 3.1e-06 26.7 0.0 1.8e-05 24.2 0.0 1.9 1 1 1 2 2 2 1 ATPase MipZ AAA_31 PF13614.6 CRG87347.1 - 2.3e-05 24.4 0.0 5.9e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 CRG87347.1 - 0.00018 20.8 0.0 0.00033 19.9 0.0 1.5 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_25 PF13481.6 CRG87347.1 - 0.0029 17.2 0.3 0.0061 16.2 0.3 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 CRG87347.1 - 0.0058 15.6 0.0 0.0096 14.9 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB CBP_BcsQ PF06564.12 CRG87347.1 - 0.0062 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_26 PF13500.6 CRG87347.1 - 0.011 15.5 0.6 4.3 7.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain COG2 PF06148.11 CRG87349.1 - 5.8e-34 117.0 1.8 5.8e-34 117.0 1.8 1.9 2 1 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 CRG87349.1 - 6.8e-05 22.9 0.1 6.8e-05 22.9 0.1 3.5 2 2 1 3 3 3 1 Vps51/Vps67 COG5 PF10392.9 CRG87349.1 - 0.00055 20.1 1.2 0.00055 20.1 1.2 2.2 2 0 0 2 2 2 1 Golgi transport complex subunit 5 SKA2 PF16740.5 CRG87349.1 - 0.014 15.2 6.0 0.059 13.2 0.1 3.0 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 Sec8_exocyst PF04048.14 CRG87349.1 - 0.029 14.2 0.6 0.071 13.0 0.6 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 CRG87349.1 - 0.042 13.1 0.2 0.087 12.1 0.2 1.5 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex HD_4 PF13328.6 CRG87349.1 - 0.12 12.1 0.7 0.84 9.4 0.7 2.4 1 1 1 2 2 2 0 HD domain Ribosomal_L1 PF00687.21 CRG87350.1 - 9.2e-25 87.6 0.0 1.1e-24 87.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family tRNA-synt_1c PF00749.21 CRG87351.1 - 1.8e-101 339.1 0.0 2.5e-101 338.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CRG87351.1 - 2.1e-39 135.2 0.0 3.3e-39 134.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C PF00043.25 CRG87351.1 - 0.0032 17.6 0.0 0.0068 16.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tetraspanin PF00335.20 CRG87352.1 - 2.6e-05 24.1 6.3 0.00017 21.4 6.3 1.9 1 1 0 1 1 1 1 Tetraspanin family CytB6-F_Fe-S PF08802.10 CRG87352.1 - 4.3 7.4 7.9 22 5.2 1.0 2.7 2 0 0 2 2 2 0 Cytochrome B6-F complex Fe-S subunit Arylesterase PF01731.20 CRG87353.1 - 0.00044 20.4 0.1 0.00089 19.4 0.1 1.5 1 0 0 1 1 1 1 Arylesterase SGL PF08450.12 CRG87353.1 - 0.026 14.1 0.0 0.041 13.4 0.0 1.3 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region E1-E2_ATPase PF00122.20 CRG87354.1 - 5.2e-35 120.6 5.0 4.6e-23 81.7 0.3 3.6 3 0 0 3 3 3 3 E1-E2 ATPase Hydrolase PF00702.26 CRG87354.1 - 1e-18 68.4 0.0 2.2e-18 67.3 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG87354.1 - 1e-10 41.1 0.0 2.3e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CRG87354.1 - 0.0067 16.2 0.2 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase CDC45 PF02724.14 CRG87354.1 - 0.27 9.5 6.9 0.56 8.4 6.9 1.4 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 CRG87354.1 - 0.6 8.2 7.0 0.84 7.8 7.0 1.1 1 0 0 1 1 1 0 Nop14-like family Roughex PF06020.11 CRG87354.1 - 3.5 6.6 8.8 5.9 5.9 8.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein RTA1 PF04479.13 CRG87355.1 - 1.4e-53 181.6 5.9 2.1e-53 181.0 5.9 1.2 1 0 0 1 1 1 1 RTA1 like protein ATP-synt_I PF03899.15 CRG87355.1 - 0.053 13.9 0.6 0.053 13.9 0.6 2.6 2 0 0 2 2 2 0 ATP synthase I chain Zn_clus PF00172.18 CRG87356.1 - 4e-10 39.6 9.3 7.7e-10 38.7 9.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG87356.1 - 2.7e-09 36.3 0.1 4.3e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_18 PF00704.28 CRG87357.1 - 5.6e-23 82.2 5.3 6.4e-22 78.7 5.3 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3638 PF12340.8 CRG87358.1 - 1.4e-84 283.0 0.2 2.4e-84 282.2 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 CRG87358.1 - 2.4e-11 42.8 0.2 4.6e-11 41.9 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) MPM1 PF17234.2 CRG87359.1 - 0.02 15.2 4.1 0.021 15.1 2.5 1.8 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Questin_oxidase PF14027.6 CRG87360.1 - 3.9e-99 332.4 0.1 4.6e-99 332.2 0.1 1.0 1 0 0 1 1 1 1 Questin oxidase-like Aldo_ket_red PF00248.21 CRG87361.1 - 3.5e-30 105.2 0.0 3.6e-29 101.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family ERCC3_RAD25_C PF16203.5 CRG87362.1 - 2.6e-123 410.0 0.9 4.2e-123 409.4 0.4 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 CRG87362.1 - 1.1e-33 116.1 0.0 3e-33 114.7 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG87362.1 - 4.9e-16 59.2 0.0 9.5e-16 58.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG87362.1 - 3.5e-13 49.9 0.1 8.5e-13 48.6 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 CRG87362.1 - 1.7e-08 33.6 0.0 2e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 CRG87362.1 - 0.00043 20.1 0.0 0.00078 19.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 CRG87362.1 - 0.002 17.1 0.0 0.0035 16.3 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 DUF4677 PF15726.5 CRG87362.1 - 0.012 15.8 0.8 0.029 14.5 0.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) AChE_tetra PF08674.10 CRG87362.1 - 6.1 6.6 5.5 1.8 8.3 0.9 2.5 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain DUF4748 PF15932.5 CRG87363.1 - 3.2e-23 81.2 0.8 6.9e-23 80.2 0.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) CTD_bind PF04818.13 CRG87364.1 - 8.9e-12 45.7 0.1 4.1e-11 43.5 0.0 2.1 2 1 1 3 3 3 1 RNA polymerase II-binding domain. SOG2 PF10428.9 CRG87364.1 - 3 6.9 8.9 5 6.2 8.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SDA1 PF05285.12 CRG87365.1 - 0.00052 19.5 8.9 0.00066 19.2 8.9 1.1 1 0 0 1 1 1 1 SDA1 TRAP_alpha PF03896.16 CRG87365.1 - 0.0042 16.3 6.7 0.0058 15.9 6.7 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.22 CRG87365.1 - 0.0072 15.6 0.1 0.011 14.9 0.1 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter CbtA PF09490.10 CRG87365.1 - 0.01 15.6 1.0 0.01 15.6 1.0 1.6 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) KRTAP PF11759.8 CRG87365.1 - 0.034 14.7 2.2 0.058 14.0 2.2 1.3 1 0 0 1 1 1 0 Keratin-associated matrix DUF4471 PF14740.6 CRG87365.1 - 0.045 13.0 0.2 0.056 12.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) B277 PF17623.2 CRG87365.1 - 0.049 12.7 0.9 0.082 12.0 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF3391 PF11871.8 CRG87365.1 - 0.061 13.9 3.3 0.25 11.9 1.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) DUF5523 PF17661.1 CRG87365.1 - 0.082 12.6 11.2 0.11 12.1 11.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Gcd10p PF04189.13 CRG87365.1 - 0.1 11.7 0.6 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 Gcd10p family CPSF100_C PF13299.6 CRG87365.1 - 0.11 12.7 3.2 0.18 12.0 3.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 CRG87365.1 - 0.14 10.3 24.8 0.18 9.9 24.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Med17 PF10156.9 CRG87365.1 - 0.14 10.8 2.6 0.17 10.6 2.6 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex DNA_primase_lrg PF04104.14 CRG87365.1 - 0.17 11.3 0.2 0.23 10.9 0.2 1.1 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit MscS_TM PF12794.7 CRG87365.1 - 0.19 10.5 0.6 0.26 10.1 0.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4746 PF15928.5 CRG87365.1 - 0.22 10.9 13.2 0.3 10.5 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) IncF PF17626.2 CRG87365.1 - 0.35 11.2 12.4 0.86 10.0 2.9 2.2 2 0 0 2 2 2 0 Inclusion membrane protein F CDC45 PF02724.14 CRG87365.1 - 0.47 8.7 14.9 0.61 8.3 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Med8 PF10232.9 CRG87365.1 - 0.58 9.7 6.1 1.1 8.8 6.1 1.4 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Usp PF00582.26 CRG87365.1 - 0.73 10.3 8.2 1.4 9.4 8.2 1.4 1 0 0 1 1 1 0 Universal stress protein family TFIIA PF03153.13 CRG87365.1 - 0.73 9.8 8.6 0.86 9.5 8.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 CRG87365.1 - 0.79 7.9 20.7 0.99 7.5 20.7 1.0 1 0 0 1 1 1 0 Nop14-like family FYDLN_acid PF09538.10 CRG87365.1 - 0.82 10.4 13.3 1.7 9.3 13.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Cytomega_UL84 PF06284.11 CRG87365.1 - 0.83 8.0 4.3 1.1 7.7 4.3 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF1840 PF08895.11 CRG87365.1 - 1.2 9.5 5.6 2.2 8.7 5.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) CobT PF06213.12 CRG87365.1 - 1.4 8.3 16.2 1.9 7.8 16.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mpp10 PF04006.12 CRG87365.1 - 1.8 6.9 18.7 2.4 6.5 18.7 1.1 1 0 0 1 1 1 0 Mpp10 protein BUD22 PF09073.10 CRG87365.1 - 1.9 7.7 14.0 2.7 7.3 14.0 1.1 1 0 0 1 1 1 0 BUD22 Connexin PF00029.19 CRG87365.1 - 2.2 7.9 4.6 2.7 7.7 4.6 1.3 1 1 0 1 1 1 0 Connexin Paf1 PF03985.13 CRG87365.1 - 2.9 6.8 18.9 3.9 6.4 18.9 1.1 1 0 0 1 1 1 0 Paf1 BSP_II PF05432.11 CRG87365.1 - 3.1 7.4 23.6 5.2 6.7 23.6 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Tim54 PF11711.8 CRG87365.1 - 3.4 6.4 6.7 4.5 5.9 6.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NOA36 PF06524.12 CRG87365.1 - 3.5 6.9 18.4 5.1 6.3 18.4 1.2 1 0 0 1 1 1 0 NOA36 protein TFB6 PF17110.5 CRG87365.1 - 3.9 7.2 11.3 6 6.6 11.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RXT2_N PF08595.11 CRG87365.1 - 4.8 7.2 10.3 7.5 6.6 10.3 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal CDC27 PF09507.10 CRG87365.1 - 5.3 6.3 11.7 6.8 6.0 11.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pes-10 PF07149.11 CRG87365.1 - 5.7 5.9 17.0 7.1 5.6 17.0 1.1 1 0 0 1 1 1 0 Pes-10 DUF4820 PF16091.5 CRG87365.1 - 6.3 6.1 6.7 9.9 5.4 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) COPI_C PF06957.11 CRG87365.1 - 7.5 5.2 6.6 9.9 4.8 6.6 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus DUF1682 PF07946.14 CRG87365.1 - 9.2 5.4 10.0 12 4.9 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RNA_pol_3_Rpc31 PF11705.8 CRG87365.1 - 9.5 6.4 25.8 13 5.9 25.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Glyco_hydro_3_C PF01915.22 CRG87366.1 - 2.7e-54 184.2 0.0 5.3e-54 183.3 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG87366.1 - 3.1e-47 161.5 0.0 5e-47 160.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG87366.1 - 1.4e-22 79.5 1.4 3.8e-21 75.0 0.3 3.0 3 0 0 3 3 3 1 Fibronectin type III-like domain PA14 PF07691.12 CRG87366.1 - 4.3e-18 65.5 0.2 8.8e-18 64.5 0.2 1.4 1 0 0 1 1 1 1 PA14 domain Phage_tail_X PF05489.12 CRG87366.1 - 0.053 13.2 0.1 0.14 11.8 0.1 1.7 1 0 0 1 1 1 0 Phage Tail Protein X NPCBM_assoc PF10633.9 CRG87366.1 - 0.09 13.0 1.4 0.16 12.2 0.4 2.0 2 0 0 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF11 PF01345.18 CRG87366.1 - 0.13 12.6 0.3 1.5 9.1 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function DUF11 Recep_L_domain PF01030.24 CRG87369.1 - 1.8e-05 24.8 0.0 0.094 12.8 0.0 3.5 2 1 0 3 3 3 2 Receptor L domain SKG6 PF08693.10 CRG87369.1 - 0.0001 21.6 0.2 0.0002 20.7 0.2 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Ecm33 PF12454.8 CRG87369.1 - 0.00014 21.9 0.0 0.00014 21.9 0.0 2.5 3 0 0 3 3 3 1 GPI-anchored cell wall organization protein TMEM51 PF15345.6 CRG87369.1 - 0.036 13.9 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 TMEM154 PF15102.6 CRG87369.1 - 0.077 12.9 0.5 0.22 11.4 0.5 1.7 1 0 0 1 1 1 0 TMEM154 protein family Macoilin PF09726.9 CRG87369.1 - 1 7.8 3.7 1.4 7.4 3.7 1.1 1 0 0 1 1 1 0 Macoilin family Zn_clus PF00172.18 CRG87370.1 - 2.1e-07 30.9 8.9 3.2e-07 30.4 8.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG87370.1 - 0.019 13.8 0.9 0.041 12.7 0.1 1.9 2 0 0 2 2 2 0 Fungal specific transcription factor domain EMP24_GP25L PF01105.24 CRG87371.1 - 4.3e-46 157.1 4.2 4.9e-46 157.0 4.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD USP7_ICP0_bdg PF12436.8 CRG87372.1 - 8.3e-84 280.7 1.7 8.6e-84 280.6 0.6 1.6 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 CRG87372.1 - 7.3e-75 251.2 3.2 7.2e-73 244.7 0.4 2.6 2 0 0 2 2 2 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 CRG87372.1 - 9.9e-48 162.9 1.5 9.9e-48 162.9 1.5 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG87372.1 - 1.1e-20 74.5 0.1 2.7e-20 73.2 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 CRG87372.1 - 7.4e-08 32.5 0.0 4.2e-07 30.1 0.0 2.4 1 0 0 1 1 1 1 MATH domain UN_NPL4 PF11543.8 CRG87372.1 - 0.053 14.0 0.1 1 9.9 0.0 2.5 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 Peptidase_C98 PF15499.6 CRG87372.1 - 0.099 12.1 0.4 0.27 10.7 0.3 1.8 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase PQ-loop PF04193.14 CRG87374.1 - 1.9e-05 24.3 0.5 8.6e-05 22.2 0.5 2.2 1 0 0 1 1 1 1 PQ loop repeat DUF5391 PF17369.2 CRG87374.1 - 0.36 10.9 6.4 0.8 9.8 6.4 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5391) CPP1-like PF11833.8 CRG87374.1 - 2.2 7.9 6.5 1.3 8.6 3.8 2.0 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like BCDHK_Adom3 PF10436.9 CRG87376.1 - 9.4e-46 155.6 0.0 1.7e-45 154.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase SPC22 PF04573.12 CRG87376.1 - 5.5e-34 117.1 0.0 6.4e-32 110.4 0.0 2.2 1 1 0 1 1 1 1 Signal peptidase subunit HATPase_c PF02518.26 CRG87376.1 - 0.00024 21.6 0.0 0.001 19.6 0.0 1.9 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HDA2-3 PF11496.8 CRG87377.1 - 1.7e-43 148.9 0.2 8.7e-42 143.3 0.0 3.0 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DUF823 PF05689.11 CRG87377.1 - 0.0047 16.7 1.2 0.012 15.4 1.2 1.6 1 0 0 1 1 1 1 Salmonella repeat of unknown function (DUF823) DUF3584 PF12128.8 CRG87377.1 - 0.023 12.3 36.8 0.036 11.6 36.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) L27 PF02828.16 CRG87377.1 - 0.53 10.1 3.6 0.71 9.7 0.2 2.5 2 0 0 2 2 2 0 L27 domain DUF730 PF05325.11 CRG87377.1 - 2.1 8.4 6.4 1 9.4 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF730) Citrate_synt PF00285.21 CRG87378.1 - 1.5e-94 317.0 0.2 2.1e-94 316.6 0.2 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PBP PF01161.20 CRG87378.1 - 1.3e-15 57.9 0.0 2.3e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein MmgE_PrpD PF03972.14 CRG87379.1 - 5.5e-114 381.1 1.3 6.9e-114 380.8 1.3 1.1 1 0 0 1 1 1 1 MmgE/PrpD family TAL_effector PF03377.13 CRG87379.1 - 0.09 13.1 0.0 0.35 11.2 0.0 2.1 1 0 0 1 1 1 0 TAL effector repeat Methyltransf_25 PF13649.6 CRG87380.1 - 0.022 15.4 0.0 0.04 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 CRG87382.1 - 4.8e-39 134.3 28.1 5.8e-39 134.0 28.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG87382.1 - 1.8e-14 53.5 4.4 1.8e-14 53.5 4.4 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CRG87382.1 - 0.00053 19.4 2.9 0.00053 19.4 2.9 2.3 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CRG87382.1 - 0.42 8.9 9.2 4.6 5.4 5.2 2.6 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF4133 PF13571.6 CRG87382.1 - 0.42 11.0 0.1 0.42 11.0 0.1 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4133) FMO-like PF00743.19 CRG87383.1 - 7.3e-37 127.0 0.0 1.2e-23 83.4 0.0 2.5 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG87383.1 - 1.6e-12 47.4 0.1 8.5e-11 41.6 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG87383.1 - 2.1e-06 27.1 0.3 3.6e-05 23.1 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CRG87383.1 - 5.3e-05 22.6 0.0 0.00028 20.2 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG87383.1 - 0.023 14.7 0.1 9.4 6.2 0.0 3.1 2 1 0 2 2 2 0 FAD-NAD(P)-binding BDV_P10 PF06515.11 CRG87383.1 - 0.17 11.9 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 Borna disease virus P10 protein CorA PF01544.18 CRG87385.1 - 4.3e-09 36.1 0.1 6.7e-09 35.5 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Ank_2 PF12796.7 CRG87386.1 - 7.6e-62 205.9 7.0 1.5e-15 57.5 0.1 5.9 2 1 4 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG87386.1 - 6e-58 192.5 1.7 2.8e-12 46.9 0.0 7.8 6 1 2 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG87386.1 - 9.9e-51 168.1 11.7 6.4e-07 29.5 0.0 11.1 11 0 0 11 11 11 9 Ankyrin repeat Ank_3 PF13606.6 CRG87386.1 - 1.9e-43 141.4 3.6 3.1e-06 27.1 0.0 11.2 10 0 0 10 10 10 8 Ankyrin repeat Ank_5 PF13857.6 CRG87386.1 - 1.1e-40 137.1 1.8 1.3e-12 47.7 0.0 7.7 4 2 3 7 7 7 6 Ankyrin repeats (many copies) AAA_16 PF13191.6 CRG87386.1 - 7.2e-06 26.5 0.0 0.00059 20.3 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain PNP_UDP_1 PF01048.20 CRG87386.1 - 8.5e-06 25.2 0.2 0.0078 15.5 0.0 2.6 3 0 0 3 3 3 2 Phosphorylase superfamily NACHT PF05729.12 CRG87386.1 - 0.034 14.1 0.0 0.098 12.6 0.0 1.8 1 0 0 1 1 1 0 NACHT domain ERp29 PF07749.12 CRG87386.1 - 0.062 14.2 0.0 0.21 12.5 0.0 1.8 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain VWA_3_C PF18571.1 CRG87386.1 - 0.64 9.9 8.1 2 8.4 0.0 4.5 6 0 0 6 6 6 0 von Willebrand factor type A C-terminal domain POT1 PF02765.17 CRG87387.1 - 9.3e-15 54.7 0.0 1.9e-14 53.7 0.0 1.5 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 REPA_OB_2 PF16900.5 CRG87387.1 - 0.00029 20.7 0.1 0.00064 19.6 0.1 1.5 1 0 0 1 1 1 1 Replication protein A OB domain IF4E PF01652.18 CRG87388.1 - 1.6e-54 184.0 0.0 2.7e-54 183.3 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Peptidase_C48 PF02902.19 CRG87389.1 - 4e-36 124.9 0.0 8.4e-36 123.8 0.0 1.5 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain GGACT PF06094.12 CRG87390.1 - 2.8e-12 47.3 0.0 5.1e-12 46.5 0.0 1.4 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like SOG2 PF10428.9 CRG87391.1 - 0.14 11.3 14.7 0.19 10.9 14.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein FXMRP1_C_core PF12235.8 CRG87391.1 - 3.6 8.2 11.5 8.3 7.1 11.5 1.5 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Presenilin PF01080.17 CRG87391.1 - 6.7 5.4 6.0 11 4.6 6.0 1.3 1 0 0 1 1 1 0 Presenilin GTP_cyclohydroI PF01227.22 CRG87392.1 - 4.2e-72 241.3 0.2 5.6e-72 240.9 0.2 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 CRG87392.1 - 0.0067 16.6 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 QueF-like protein CAF1C_H4-bd PF12265.8 CRG87393.1 - 1.3e-28 99.1 0.9 6.8e-28 96.7 0.9 2.2 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 CRG87393.1 - 6.5e-28 96.4 6.3 3.1e-05 24.6 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87393.1 - 1.2e-07 31.9 1.1 0.0063 16.8 0.1 4.7 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG87393.1 - 0.0081 14.8 2.9 6.5 5.3 0.1 3.8 1 1 0 3 3 3 2 Nucleoporin Nup120/160 XRN_M PF17846.1 CRG87394.1 - 8.3e-99 331.5 2.0 8.3e-99 331.5 2.0 2.1 3 0 0 3 3 3 1 Xrn1 helical domain XRN_N PF03159.18 CRG87394.1 - 2.5e-96 321.8 0.0 2.5e-96 321.8 0.0 2.1 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 CRG87394.1 - 9e-75 250.7 0.0 2.1e-74 249.5 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain Pkinase PF00069.25 CRG87394.1 - 3.4e-71 239.7 0.0 5.8e-71 238.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain XRN1_D2_D3 PF18334.1 CRG87394.1 - 1.5e-32 111.6 0.0 8.3e-32 109.3 0.0 2.3 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain Pkinase_Tyr PF07714.17 CRG87394.1 - 3e-32 111.9 0.0 6.4e-32 110.8 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase SH3_12 PF18129.1 CRG87394.1 - 2.1e-23 82.2 1.4 5e-23 81.0 1.4 1.7 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 CRG87394.1 - 4.3e-07 29.9 1.1 1.2e-06 28.5 1.1 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 Kinase-like PF14531.6 CRG87394.1 - 0.026 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like NUDIX PF00293.28 CRG87395.1 - 8.3e-18 64.7 0.1 1.7e-17 63.7 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 CRG87395.1 - 5.3e-13 49.5 0.0 1.5e-12 48.1 0.0 1.8 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 CRG87395.1 - 0.00018 21.1 1.0 0.00032 20.3 1.0 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain TrkA_N PF02254.18 CRG87395.1 - 0.011 15.9 0.0 0.027 14.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain DUF4139 PF13598.6 CRG87396.1 - 1.3e-34 119.8 0.9 2.2e-34 119.0 0.0 1.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4139) DUF4140 PF13600.6 CRG87396.1 - 6.2e-18 65.0 0.5 6.2e-18 65.0 0.5 3.3 2 1 0 2 2 2 1 N-terminal domain of unknown function (DUF4140) NMT1_3 PF16868.5 CRG87397.1 - 0.19 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family PQ-loop PF04193.14 CRG87398.1 - 3e-21 74.9 0.5 2.8e-11 43.0 0.0 2.6 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 CRG87398.1 - 0.023 15.5 2.7 0.11 13.3 2.7 2.0 1 1 0 1 1 1 0 ER lumen protein retaining receptor Glyco_hydro_31 PF01055.26 CRG87399.1 - 1.1e-137 459.8 9.2 1.6e-137 459.3 9.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CRG87399.1 - 1.2e-25 89.6 0.7 7.6e-25 87.0 0.2 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 CRG87399.1 - 4e-07 30.2 0.1 1.3e-06 28.6 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Hepar_II_III PF07940.13 CRG87399.1 - 0.066 12.8 0.4 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Heparinase II/III-like protein NDK PF00334.19 CRG87400.1 - 5.4e-53 178.6 0.0 6.2e-53 178.4 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase FLILHELTA PF10306.9 CRG87401.1 - 1.7e-29 102.0 0.0 3e-29 101.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 CRG87401.1 - 0.0062 17.0 0.7 0.0085 16.6 0.7 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) MTHFR PF02219.17 CRG87402.1 - 5.4e-99 331.1 0.0 1.4e-98 329.8 0.0 1.6 2 0 0 2 2 2 1 Methylenetetrahydrofolate reductase TGT PF01702.18 CRG87403.1 - 5.7e-60 203.3 0.0 7.2e-60 203.0 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Thymidylate_kin PF02223.17 CRG87404.1 - 9.3e-49 165.6 0.0 1.1e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase GIY-YIG PF01541.24 CRG87405.1 - 3.6e-13 49.6 0.0 7.5e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-HC5HC2H PF13771.6 CRG87405.1 - 0.00043 20.5 1.7 0.00084 19.6 1.7 1.5 1 0 0 1 1 1 1 PHD-like zinc-binding domain FANCL_C PF11793.8 CRG87405.1 - 0.0005 20.2 3.2 0.00093 19.3 3.2 1.4 1 0 0 1 1 1 1 FANCL C-terminal domain Prok-RING_1 PF14446.6 CRG87405.1 - 0.0076 16.2 0.9 0.0076 16.2 0.9 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zf-HC5HC2H_2 PF13832.6 CRG87405.1 - 0.012 15.7 1.0 0.025 14.7 1.0 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain PhnA_Zn_Ribbon PF08274.12 CRG87405.1 - 0.052 13.5 0.2 9.6 6.3 0.0 2.5 2 0 0 2 2 2 0 PhnA Zinc-Ribbon PHD PF00628.29 CRG87405.1 - 0.054 13.4 4.7 0.2 11.6 4.7 2.1 1 1 0 1 1 1 0 PHD-finger zf-RING-like PF08746.11 CRG87405.1 - 0.079 13.3 3.9 0.23 11.8 3.9 1.9 1 1 0 1 1 1 0 RING-like domain zf-RING_2 PF13639.6 CRG87405.1 - 0.36 11.2 5.5 0.65 10.4 5.5 1.5 1 0 0 1 1 1 0 Ring finger domain C1_2 PF03107.16 CRG87405.1 - 1.4 9.3 4.0 0.54 10.6 1.1 1.9 2 0 0 2 2 2 0 C1 domain RXT2_N PF08595.11 CRG87405.1 - 1.7 8.6 5.3 3.6 7.6 5.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.12 CRG87405.1 - 4.2 5.5 11.1 6 5.0 11.1 1.2 1 0 0 1 1 1 0 Nop14-like family DUF1168 PF06658.12 CRG87405.1 - 5.1 6.9 9.8 0.43 10.4 2.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Pox_Ag35 PF03286.14 CRG87405.1 - 9 6.0 12.8 0.36 10.6 7.1 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PLU-1 PF08429.11 CRG87406.1 - 6.3e-108 361.0 29.7 8e-104 347.4 26.3 2.2 2 0 0 2 2 2 2 PLU-1-like protein JmjC PF02373.22 CRG87406.1 - 2.6e-43 147.0 0.2 7.2e-43 145.6 0.2 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 CRG87406.1 - 7e-22 77.9 0.1 2.9e-21 76.0 0.1 2.1 2 0 0 2 2 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 CRG87406.1 - 3.9e-16 58.7 1.4 9.1e-16 57.5 1.4 1.7 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 CRG87406.1 - 6.1e-16 58.1 32.6 3.1e-09 36.6 8.1 3.6 3 0 0 3 3 3 2 PHD-finger zf-C5HC2 PF02928.16 CRG87406.1 - 1.6e-10 41.2 4.9 6.4e-10 39.3 4.9 2.2 1 0 0 1 1 1 1 C5HC2 zinc finger Prok-RING_1 PF14446.6 CRG87406.1 - 0.0039 17.1 4.0 0.0039 17.1 4.0 3.0 2 1 1 3 3 3 1 Prokaryotic RING finger family 1 C1_1 PF00130.22 CRG87406.1 - 0.0059 16.5 15.9 0.036 13.9 0.6 3.3 3 0 0 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CRG87406.1 - 0.008 16.5 1.1 0.008 16.5 1.1 4.5 3 1 1 4 4 4 1 C1 domain PHD_4 PF16866.5 CRG87406.1 - 0.046 13.8 24.4 0.048 13.7 5.8 3.3 3 0 0 3 3 3 0 PHD-finger zf-PHD-like PF15446.6 CRG87406.1 - 0.07 12.8 11.3 0.065 12.9 0.8 3.1 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain DUF5345 PF17280.2 CRG87406.1 - 0.91 9.5 3.1 49 4.0 1.1 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5345) zf-RanBP PF00641.18 CRG87406.1 - 1.5 8.2 8.0 2.2 7.7 0.5 2.6 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others tRNA-synt_His PF13393.6 CRG87406.1 - 1.9 7.7 6.0 0.72 9.1 2.8 2.0 2 0 0 2 2 2 0 Histidyl-tRNA synthetase zf-HC5HC2H PF13771.6 CRG87406.1 - 3.4 8.0 21.0 0.094 13.0 3.0 3.6 3 0 0 3 3 2 0 PHD-like zinc-binding domain DnaI_N PF07319.11 CRG87406.1 - 4.6 8.0 6.9 1.1 10.0 1.5 2.9 3 0 0 3 3 1 0 Primosomal protein DnaI N-terminus Syntaxin-6_N PF09177.11 CRG87406.1 - 9 6.9 13.2 1.2 9.8 2.9 4.0 2 1 2 4 4 4 0 Syntaxin 6, N-terminal DHHA2 PF02833.14 CRG87407.1 - 4.8e-33 114.4 0.0 7.5e-33 113.7 0.0 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 CRG87407.1 - 6.4e-09 36.0 0.0 1.1e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 DHH family Transglut_core PF01841.19 CRG87408.1 - 2.3e-07 31.2 0.0 5.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Transglutaminase-like superfamily SH3_2 PF07653.17 CRG87408.1 - 3.4e-07 29.8 0.0 9.7e-07 28.4 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG87408.1 - 2.7e-05 23.7 0.0 2.7e-05 23.7 0.0 2.4 3 0 0 3 3 3 1 SH3 domain SH3_9 PF14604.6 CRG87408.1 - 0.004 17.0 2.5 0.02 14.7 0.1 3.0 3 0 0 3 3 3 1 Variant SH3 domain SAT PF16073.5 CRG87409.1 - 1.5e-81 273.6 0.0 3.6e-81 272.4 0.0 1.7 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ketoacyl-synt PF00109.26 CRG87409.1 - 1.3e-79 267.4 0.0 2.4e-79 266.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CRG87409.1 - 4.4e-41 141.4 0.0 7.7e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG87409.1 - 9.2e-36 122.4 0.1 2.1e-35 121.3 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 CRG87409.1 - 8.9e-23 81.6 0.0 3.5e-22 79.7 0.0 2.0 2 0 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 CRG87409.1 - 3.7e-22 78.4 4.5 2.3e-11 43.9 0.2 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site PS-DH PF14765.6 CRG87409.1 - 4.6e-14 52.3 0.0 9.2e-14 51.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase KAsynt_C_assoc PF16197.5 CRG87409.1 - 1.1e-06 29.1 0.0 3.1e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Abhydrolase_6 PF12697.7 CRG87409.1 - 0.0003 21.4 0.1 0.042 14.4 0.0 2.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thiolase_N PF00108.23 CRG87409.1 - 0.00068 19.1 0.0 0.0017 17.8 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain DUF2974 PF11187.8 CRG87409.1 - 0.18 11.3 0.0 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Cu-oxidase_3 PF07732.15 CRG87410.1 - 1.3e-38 131.6 2.6 3e-38 130.5 2.6 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG87410.1 - 7.7e-16 58.6 0.6 4.9e-15 56.0 0.0 2.4 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG87410.1 - 2.2e-11 43.7 2.5 3e-06 27.0 0.0 3.0 2 1 0 2 2 2 2 Multicopper oxidase Fungal_trans_2 PF11951.8 CRG87410.1 - 1.6e-09 37.1 2.7 3.1e-08 32.8 2.7 2.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87410.1 - 0.048 13.8 5.7 0.12 12.6 5.7 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Lyx_isomer PF07385.12 CRG87410.1 - 0.051 12.8 0.0 0.31 10.3 0.0 2.2 2 0 0 2 2 2 0 D-lyxose isomerase DUF4915 PF16261.5 CRG87410.1 - 0.096 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4915) SGL PF08450.12 CRG87411.1 - 0.011 15.3 0.0 0.02 14.5 0.0 1.6 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Scytalone_dh PF02982.14 CRG87412.1 - 1.7e-80 268.5 1.8 1.9e-80 268.2 1.8 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 CRG87412.1 - 2.3e-09 37.4 1.2 3.1e-09 37.0 1.2 1.1 1 0 0 1 1 1 1 SnoaL-like domain adh_short_C2 PF13561.6 CRG87413.1 - 2.7e-55 187.5 0.1 5.1e-55 186.6 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87413.1 - 6.6e-45 153.0 0.2 8.6e-45 152.6 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87413.1 - 1.5e-15 57.6 0.2 1.9e-15 57.3 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG87413.1 - 0.099 12.1 0.2 0.29 10.5 0.2 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1100 PF06500.11 CRG87414.1 - 1.4e-08 33.9 0.0 1.8e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Peptidase_S9 PF00326.21 CRG87414.1 - 6.6e-05 22.5 0.0 0.00018 21.1 0.0 1.7 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CRG87414.1 - 0.00013 21.6 0.0 0.00029 20.5 0.1 1.5 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) BAAT_C PF08840.11 CRG87414.1 - 0.0045 16.9 0.0 0.01 15.8 0.0 1.5 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 CRG87414.1 - 0.016 14.8 0.0 0.22 11.0 0.0 2.1 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 CRG87414.1 - 0.032 14.8 1.8 0.047 14.3 1.0 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Esterase PF00756.20 CRG87414.1 - 0.041 13.5 0.1 0.29 10.8 0.1 2.1 1 1 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 CRG87414.1 - 0.18 11.0 0.0 0.38 10.0 0.0 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 TPR_2 PF07719.17 CRG87414.1 - 0.2 11.9 0.9 0.66 10.2 0.9 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Cu-oxidase_3 PF07732.15 CRG87415.1 - 2.3e-39 134.1 7.3 5.8e-39 132.8 0.4 3.4 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG87415.1 - 2.4e-38 130.9 10.1 2.1e-35 121.5 1.6 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CRG87415.1 - 2.1e-35 122.2 0.9 1e-34 119.9 0.1 2.4 3 0 0 3 3 3 1 Multicopper oxidase Cyclase PF04199.13 CRG87416.1 - 1.6e-15 57.6 0.0 2.1e-15 57.2 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase DUF5490 PF17593.2 CRG87416.1 - 0.022 14.8 0.0 0.06 13.4 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5490) WD40 PF00400.32 CRG87417.1 - 2.5e-38 129.4 21.0 1.6e-07 31.9 0.1 12.5 14 0 0 14 14 14 6 WD domain, G-beta repeat Utp12 PF04003.12 CRG87417.1 - 1.6e-27 95.9 0.1 2.8e-27 95.1 0.1 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 CRG87417.1 - 1.9e-19 69.7 0.0 0.41 11.0 0.1 9.4 4 2 6 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG87417.1 - 6.6e-09 35.2 0.4 0.12 11.3 0.1 4.9 3 2 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CRG87417.1 - 7.8e-05 22.6 2.6 0.46 10.3 0.1 5.5 5 3 1 6 6 6 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 CRG87417.1 - 0.024 13.2 0.0 0.2 10.2 0.0 2.5 3 0 0 3 3 3 0 Cytochrome D1 heme domain Utp21 PF04192.12 CRG87417.1 - 0.15 11.6 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain PQQ_3 PF13570.6 CRG87417.1 - 0.32 11.5 8.6 39 4.9 0.0 5.9 7 0 0 7 7 7 0 PQQ-like domain Septin PF00735.18 CRG87418.1 - 5.4e-115 383.5 0.3 7.5e-115 383.0 0.3 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 CRG87418.1 - 1.6e-07 31.4 0.0 3.4e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG87418.1 - 4.8e-06 26.6 0.0 6.2e-05 23.0 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 CRG87418.1 - 9.9e-06 25.2 4.1 9.9e-05 22.0 0.5 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CRG87418.1 - 0.0008 19.7 0.6 0.0023 18.2 0.1 2.1 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 CRG87418.1 - 0.0029 17.1 0.1 0.0052 16.3 0.1 1.3 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 CRG87418.1 - 0.0037 17.5 0.2 0.0084 16.3 0.2 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 CRG87418.1 - 0.0061 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 AIG1 family FOXP-CC PF16159.5 CRG87418.1 - 0.0069 17.0 1.0 0.024 15.2 1.0 1.9 1 0 0 1 1 1 1 FOXP coiled-coil domain IIGP PF05049.13 CRG87418.1 - 0.0081 15.3 0.0 0.016 14.3 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.6 CRG87418.1 - 0.015 15.0 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CRG87418.1 - 0.023 15.1 0.6 0.087 13.2 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CRG87418.1 - 0.028 14.9 0.3 0.18 12.3 0.0 2.2 2 1 0 2 2 2 0 ABC transporter T2SSE PF00437.20 CRG87418.1 - 0.03 13.4 0.6 0.08 12.0 0.1 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein KAP_NTPase PF07693.14 CRG87418.1 - 0.037 13.3 0.0 0.05 12.8 0.0 1.5 1 1 0 1 1 1 0 KAP family P-loop domain Ras PF00071.22 CRG87418.1 - 0.042 13.4 1.1 0.13 11.8 0.5 2.1 2 1 0 2 2 2 0 Ras family Casc1_N PF15927.5 CRG87418.1 - 0.048 13.3 8.6 0.12 12.1 8.6 1.6 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus NACHT PF05729.12 CRG87418.1 - 0.058 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 CRG87418.1 - 0.09 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain PduV-EutP PF10662.9 CRG87418.1 - 0.1 12.4 0.4 4.2 7.1 0.4 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 CRG87418.1 - 0.12 12.8 0.0 0.3 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP_bind_1 PF03029.17 CRG87418.1 - 0.18 11.5 1.0 12 5.6 0.1 2.8 1 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 CRG87418.1 - 0.58 10.2 6.5 3.6 7.6 0.1 3.0 2 1 1 3 3 3 0 Dynamin family AAA_11 PF13086.6 CRG87418.1 - 3.6 7.3 6.1 26 4.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 CRG87419.1 - 6.9e-16 58.3 21.6 0.00017 22.3 0.3 7.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87419.1 - 5.1e-08 33.1 0.7 0.22 11.8 0.0 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG87419.1 - 0.00044 20.2 0.0 0.03 14.2 0.0 3.2 3 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A PQQ PF01011.21 CRG87419.1 - 0.00095 19.0 0.0 0.16 12.0 0.0 3.0 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_3 PF13570.6 CRG87419.1 - 0.78 10.3 6.0 3.1 8.4 0.1 4.5 5 0 0 5 5 5 0 PQQ-like domain LCCL PF03815.19 CRG87420.1 - 8.1e-20 70.7 0.5 1.4e-19 70.0 0.5 1.3 1 0 0 1 1 1 1 LCCL domain DUF1282 PF06930.12 CRG87420.1 - 3.1 7.5 11.8 0.075 12.8 4.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1282) Aminotran_1_2 PF00155.21 CRG87421.1 - 4.1e-11 42.7 0.0 1e-10 41.3 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Zn_clus PF00172.18 CRG87422.1 - 3.4e-08 33.5 11.7 6.2e-08 32.6 11.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sdh5 PF03937.16 CRG87423.1 - 3.6e-24 84.5 0.4 1.3e-23 82.7 0.5 1.9 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase WD40 PF00400.32 CRG87424.1 - 6.4e-45 150.2 21.7 1.6e-09 38.2 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87424.1 - 6.1e-10 39.3 0.3 0.057 13.7 0.0 4.3 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG87424.1 - 1e-05 24.4 5.7 0.3 9.7 0.0 4.6 2 1 3 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 CRG87424.1 - 0.00068 19.6 0.0 0.85 9.5 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CRG87424.1 - 0.0022 17.0 0.1 11 4.8 0.0 3.8 2 2 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CRG87424.1 - 0.0079 14.8 0.0 0.73 8.3 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 CRG87424.1 - 0.013 15.5 0.2 22 5.1 0.0 4.5 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 CRG87424.1 - 0.021 14.1 0.0 0.98 8.7 0.0 2.3 2 1 0 2 2 2 0 WD40-like domain ABC2_membrane PF01061.24 CRG87425.1 - 1e-28 100.2 32.2 1.6e-28 99.5 32.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CRG87425.1 - 4.7e-27 95.2 0.3 4.7e-27 95.2 0.3 1.6 2 0 0 2 2 1 1 ABC transporter RsgA_GTPase PF03193.16 CRG87425.1 - 4.8e-06 26.6 0.4 0.0001 22.2 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CRG87425.1 - 1.3e-05 25.7 0.1 3.3e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 CRG87425.1 - 2.7e-05 23.8 0.1 5e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CRG87425.1 - 6.9e-05 23.3 0.2 0.00038 20.9 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CRG87425.1 - 0.00016 21.7 0.0 0.00036 20.5 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_21 PF13304.6 CRG87425.1 - 0.00037 20.4 0.1 1.1 9.1 0.0 2.5 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG87425.1 - 0.00053 19.5 0.1 0.00099 18.6 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG87425.1 - 0.0032 17.8 0.6 0.017 15.4 0.1 2.3 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CRG87425.1 - 0.0074 16.8 0.0 0.017 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 CRG87425.1 - 0.012 15.5 0.4 0.048 13.6 0.1 2.1 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CRG87425.1 - 0.013 15.3 0.4 0.028 14.1 0.1 1.7 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 CRG87425.1 - 0.013 15.7 0.1 0.025 14.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CRG87425.1 - 0.014 14.9 0.1 2.2 7.8 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 CRG87425.1 - 0.019 14.7 0.0 0.038 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 CRG87425.1 - 0.02 15.3 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase T2SSE PF00437.20 CRG87425.1 - 0.033 13.2 0.1 0.29 10.1 0.1 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein MobB PF03205.14 CRG87425.1 - 0.034 14.0 0.0 0.16 11.8 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 CRG87425.1 - 0.04 13.9 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MMR_HSR1 PF01926.23 CRG87425.1 - 0.041 14.0 0.2 0.13 12.3 0.1 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_5 PF07728.14 CRG87425.1 - 0.051 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CRG87425.1 - 0.06 13.5 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CRG87425.1 - 0.068 13.1 0.1 0.17 11.8 0.1 1.7 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.6 CRG87425.1 - 0.078 13.0 0.0 0.24 11.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain Viral_helicase1 PF01443.18 CRG87425.1 - 0.087 12.6 0.2 8.3 6.1 0.0 2.7 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase ATPase_2 PF01637.18 CRG87425.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 CRG87425.1 - 0.14 11.3 0.0 0.65 9.1 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 CRG87425.1 - 1.1 9.7 4.0 5.1 7.5 4.0 2.1 1 1 0 1 1 1 0 AAA domain TPR_12 PF13424.6 CRG87426.1 - 0.00079 19.7 4.1 0.67 10.3 0.0 3.9 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG87426.1 - 0.00085 19.1 0.6 0.099 12.5 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG87426.1 - 0.026 14.6 2.3 2.2 8.6 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 CRG87426.1 - 0.027 14.5 0.1 16 5.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 CRG87426.1 - 0.034 14.0 0.0 0.56 10.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG87426.1 - 0.2 12.5 5.3 1e+02 4.2 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat SRAP PF02586.14 CRG87427.1 - 2.1e-77 259.6 0.6 3.3e-77 258.9 0.0 1.5 2 0 0 2 2 2 1 SOS response associated peptidase (SRAP) ACT_7 PF13840.6 CRG87428.1 - 5e-26 90.3 0.0 1.4e-18 66.4 0.0 3.4 3 0 0 3 3 3 3 ACT domain SKIP_SNW PF02731.15 CRG87429.1 - 1.3e-72 242.7 7.1 1.3e-72 242.7 7.1 2.0 2 0 0 2 2 2 1 SKIP/SNW domain FAM60A PF15396.6 CRG87429.1 - 5.1 7.0 8.8 11 6.0 8.8 1.5 1 0 0 1 1 1 0 Protein Family FAM60A DUF3395 PF11875.8 CRG87431.1 - 3.9e-41 140.5 0.2 6.2e-41 139.9 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 CRG87431.1 - 4.7e-18 65.1 0.2 1.1e-17 63.9 0.2 1.6 1 0 0 1 1 1 1 DnaJ domain Zn_clus PF00172.18 CRG87432.1 - 1.8e-07 31.2 13.3 2.9e-07 30.5 13.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_L4 PF00573.22 CRG87433.1 - 7.6e-39 133.4 0.3 1e-38 133.0 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 CRG87433.1 - 6.2e-30 103.1 1.8 6.2e-30 103.1 1.8 1.9 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain LPMO_10 PF03067.15 CRG87434.1 - 0.00039 21.1 2.6 0.0037 17.9 0.0 2.7 2 1 1 3 3 3 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading UPF0029 PF01205.19 CRG87435.1 - 3.6e-35 120.5 0.0 5.7e-35 119.8 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 CRG87435.1 - 3.6e-08 33.7 0.0 5.7e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 RWD domain DUF1485 PF07364.12 CRG87436.1 - 1.2e-104 349.6 2.7 1.6e-104 349.3 2.7 1.1 1 0 0 1 1 1 1 Metallopeptidase family M81 MlrC_C PF07171.12 CRG87436.1 - 8.8e-61 205.2 0.2 2.4e-60 203.7 0.2 1.8 2 0 0 2 2 2 1 MlrC C-terminus DUF2200 PF09966.9 CRG87436.1 - 0.14 12.3 0.0 0.62 10.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2200) Sugar_tr PF00083.24 CRG87437.1 - 1.1e-53 182.7 10.4 3.2e-53 181.2 7.2 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG87437.1 - 2.8e-27 95.6 17.1 3.7e-27 95.2 17.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PUCC PF03209.15 CRG87437.1 - 0.00042 19.4 3.0 0.00081 18.5 3.0 1.4 1 0 0 1 1 1 1 PUCC protein MFS_4 PF06779.14 CRG87437.1 - 0.0014 18.0 4.1 0.0014 18.0 4.1 1.6 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 CRG87437.1 - 0.01 14.3 0.9 0.017 13.6 0.9 1.3 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) DUF554 PF04474.12 CRG87437.1 - 0.22 11.0 7.3 0.38 10.2 3.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF554) Rer1 PF03248.13 CRG87438.1 - 0.036 13.8 1.9 0.075 12.8 1.9 1.5 1 0 0 1 1 1 0 Rer1 family MFS_1 PF07690.16 CRG87439.1 - 8e-34 117.1 32.6 2.7e-22 79.2 12.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TPP_enzyme_N PF02776.18 CRG87440.1 - 2.4e-37 128.2 2.1 8.3e-37 126.4 1.7 2.0 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG87440.1 - 2.5e-16 59.8 0.0 5.4e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG87440.1 - 3e-09 36.7 0.2 6.4e-09 35.7 0.2 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain Sulfatase PF00884.23 CRG87441.1 - 7.3e-50 170.1 0.1 1.7e-47 162.3 0.0 2.4 2 1 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 CRG87441.1 - 1.2e-07 32.0 0.2 6.6e-07 29.5 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 CRG87441.1 - 3.7e-06 26.8 0.0 0.0079 15.8 0.0 2.2 1 1 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 CRG87441.1 - 0.0031 18.2 0.0 0.0077 17.0 0.0 1.6 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Sugar_tr PF00083.24 CRG87442.1 - 5.6e-74 249.6 7.4 6.4e-74 249.4 7.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG87442.1 - 4.2e-19 68.7 10.3 4.2e-19 68.7 10.3 1.8 1 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG87442.1 - 0.096 11.1 5.7 0.2 10.0 0.9 2.3 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) EMP24_GP25L PF01105.24 CRG87443.1 - 5.3e-40 137.3 0.0 6.1e-40 137.1 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD EzrA PF06160.12 CRG87443.1 - 0.017 13.3 0.5 0.021 13.0 0.5 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA RE_SacI PF09566.10 CRG87443.1 - 0.075 12.8 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 SacI restriction endonuclease Big_6 PF17936.1 CRG87444.1 - 0.043 14.1 0.1 0.14 12.5 0.1 1.9 1 0 0 1 1 1 0 Bacterial Ig domain GOLD_2 PF13897.6 CRG87444.1 - 0.19 12.2 2.3 0.51 10.8 2.3 1.7 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking NAGLU_C PF12972.7 CRG87445.1 - 0.19 11.2 0.1 0.28 10.7 0.1 1.2 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain FSA_C PF10479.9 CRG87446.1 - 0.54 8.3 7.7 0.86 7.7 7.7 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TauD PF02668.16 CRG87447.1 - 4.8e-45 154.5 0.2 6.1e-45 154.1 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF1257 PF06868.11 CRG87447.1 - 0.14 12.4 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1257) CCSMST1 PF15013.6 CRG87447.1 - 0.14 12.3 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 CCSMST1 family NDUFA12 PF05071.16 CRG87448.1 - 4.4e-12 46.7 6.5 2e-11 44.6 6.5 2.1 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF1870 PF08965.10 CRG87448.1 - 0.059 13.4 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) CH PF00307.31 CRG87449.1 - 2.2e-16 60.0 0.0 4e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain ORMDL PF04061.14 CRG87451.1 - 1.4e-58 196.5 5.5 1.6e-58 196.3 5.5 1.1 1 0 0 1 1 1 1 ORMDL family HAD_2 PF13419.6 CRG87452.1 - 1e-14 55.0 0.0 5.3e-14 52.7 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG87452.1 - 2.6e-13 50.7 0.0 1.7e-10 41.5 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG87452.1 - 1.6e-06 28.1 0.1 4.6e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 CRG87452.1 - 0.01 16.2 0.1 0.037 14.4 0.1 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 CRG87452.1 - 0.13 11.9 0.0 1.7 8.2 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase Hydrolase_6 PF13344.6 CRG87452.1 - 0.17 12.0 0.0 2.4 8.3 0.0 2.4 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Lactamase_B PF00753.27 CRG87454.1 - 5.1e-05 23.4 0.1 0.00016 21.7 0.1 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily zf-C3HC4_3 PF13920.6 CRG87454.1 - 0.053 13.4 0.5 0.053 13.4 0.5 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) KleE PF17394.2 CRG87454.1 - 0.063 13.5 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Carn_acyltransf PF00755.20 CRG87457.1 - 5.4e-26 91.4 0.0 1.5e-25 89.9 0.0 1.6 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase TRP PF06011.12 CRG87459.1 - 3.8e-165 549.8 30.3 4.4e-165 549.5 30.3 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CRG87459.1 - 2.4e-37 128.4 0.1 4e-37 127.7 0.1 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.15 CRG87459.1 - 0.00027 21.4 0.0 0.00046 20.6 0.0 1.3 1 0 0 1 1 1 1 ML domain Shisa PF13908.6 CRG87459.1 - 0.018 15.3 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DAG1 PF05454.11 CRG87459.1 - 0.19 11.1 0.8 1.9 7.8 0.0 2.7 3 0 0 3 3 3 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF4381 PF14316.6 CRG87459.1 - 0.41 10.9 2.1 2.6 8.3 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) SLATT_fungal PF18142.1 CRG87459.1 - 9.4 6.3 8.2 2.8 7.9 1.1 2.9 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain zf-U1 PF06220.12 CRG87460.1 - 3.4e-17 61.9 3.4 4.7e-17 61.5 3.4 1.2 1 0 0 1 1 1 1 U1 zinc finger DUF3602 PF12223.8 CRG87461.1 - 2.3e-23 82.6 5.5 8.2e-22 77.6 0.3 2.4 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) Acetyltransf_1 PF00583.25 CRG87462.1 - 6.5e-05 23.1 0.0 0.00019 21.6 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG87462.1 - 0.00028 21.3 0.0 0.0014 19.1 0.0 2.2 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG87462.1 - 0.014 15.3 0.0 0.067 13.1 0.0 2.1 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain LEAP-2 PF07359.11 CRG87462.1 - 0.027 14.3 0.4 0.65 9.9 0.1 2.7 2 0 0 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) Acetyltransf_CG PF14542.6 CRG87462.1 - 0.029 14.5 0.0 0.076 13.2 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Ank_2 PF12796.7 CRG87462.1 - 0.042 14.4 0.0 0.12 13.0 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG87462.1 - 0.085 13.5 0.1 0.55 10.9 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) CRF PF00473.17 CRG87462.1 - 0.094 12.8 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Corticotropin-releasing factor family FR47 PF08445.10 CRG87462.1 - 0.18 11.8 0.0 0.46 10.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein CBP PF12192.8 CRG87463.1 - 1.3e-16 60.5 19.6 1.3e-16 60.5 19.6 1.7 1 1 1 2 2 2 1 Fungal calcium binding protein FAD_binding_4 PF01565.23 CRG87464.1 - 7.3e-19 67.9 0.2 1.2e-18 67.2 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain THOC7 PF05615.13 CRG87464.1 - 0.0018 18.5 7.0 0.0018 18.5 7.0 2.0 2 0 0 2 2 2 1 Tho complex subunit 7 DUF3450 PF11932.8 CRG87464.1 - 0.0086 15.4 11.4 0.0086 15.4 11.4 2.1 3 0 0 3 3 3 1 Protein of unknown function (DUF3450) HIP1_clath_bdg PF16515.5 CRG87464.1 - 0.018 15.7 12.6 0.018 15.7 12.6 2.7 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cnn_1N PF07989.11 CRG87464.1 - 0.03 14.5 11.1 0.1 12.8 11.0 2.0 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 CRG87464.1 - 1.3 9.0 9.5 3.4 7.7 9.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 CRG87464.1 - 2 8.4 22.5 0.1 12.6 15.2 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OmpH PF03938.14 CRG87464.1 - 2 8.7 13.9 0.11 12.8 5.8 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) MCC-bdg_PDZ PF10506.9 CRG87464.1 - 2.9 8.0 10.6 9.5 6.3 2.5 2.9 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome TSC22 PF01166.18 CRG87464.1 - 3.7 7.9 9.7 12 6.3 3.2 2.9 2 0 0 2 2 2 0 TSC-22/dip/bun family IFT57 PF10498.9 CRG87464.1 - 8.5 5.2 19.1 0.14 11.1 11.0 1.8 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 bZIP_1 PF00170.21 CRG87464.1 - 8.8 6.5 14.3 1.4 9.0 6.0 2.5 1 1 1 2 2 2 0 bZIP transcription factor bZIP_2 PF07716.15 CRG87464.1 - 8.9 6.5 13.8 0.21 11.7 4.1 2.9 2 1 1 3 3 3 0 Basic region leucine zipper Laminin_II PF06009.12 CRG87464.1 - 9.6 6.2 13.5 3.6 7.6 10.4 1.9 2 0 0 2 2 2 0 Laminin Domain II DUF846 PF05832.12 CRG87465.1 - 2.1e-47 160.7 10.5 2.4e-47 160.5 10.5 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) TMEM220 PF15071.6 CRG87465.1 - 0.13 13.0 2.8 0.16 12.7 1.0 1.9 2 0 0 2 2 2 0 Transmembrane family 220, helix HpcH_HpaI PF03328.14 CRG87466.1 - 2.3e-41 141.4 0.0 3.2e-40 137.6 0.0 2.1 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 CRG87466.1 - 5.9e-13 48.7 0.0 3.4e-07 29.8 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold DUF1771 PF08590.10 CRG87467.1 - 1.6e-15 57.2 9.5 3.9e-15 56.0 9.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 CRG87467.1 - 9.8e-08 32.3 0.3 3.1e-07 30.6 0.3 1.9 1 0 0 1 1 1 1 Smr domain zf_CCCH_4 PF18345.1 CRG87467.1 - 2.3e-07 30.6 6.8 2.1e-05 24.4 1.2 2.7 2 1 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 CRG87467.1 - 8.2e-06 26.1 3.8 0.036 14.5 0.6 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 CRG87467.1 - 9.8e-06 25.4 2.2 0.016 15.1 0.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CRG87467.1 - 0.0028 17.4 10.1 0.0059 16.4 1.4 2.9 2 1 0 2 2 2 1 CCCH-type zinc finger CUE PF02845.16 CRG87467.1 - 0.014 15.1 0.5 0.049 13.3 0.1 2.2 2 0 0 2 2 2 0 CUE domain HBS1_N PF08938.10 CRG87467.1 - 0.069 13.4 1.3 0.091 13.1 0.0 1.9 2 0 0 2 2 1 0 HBS1 N-terminus zf-CCCH_3 PF15663.5 CRG87467.1 - 0.23 11.7 1.9 3.7 7.8 0.1 2.4 1 1 1 2 2 2 0 Zinc-finger containing family Torus PF16131.5 CRG87467.1 - 0.26 12.0 2.6 4 8.2 0.6 2.7 1 1 1 2 2 2 0 Torus domain SapB_1 PF05184.15 CRG87467.1 - 1.6 8.8 3.4 1.5 8.9 0.1 2.5 3 0 0 3 3 3 0 Saposin-like type B, region 1 SNARE_assoc PF09335.11 CRG87468.1 - 5.2e-13 49.5 4.6 5.2e-13 49.5 4.6 2.5 2 1 2 4 4 4 1 SNARE associated Golgi protein E1-E2_ATPase PF00122.20 CRG87468.1 - 0.51 9.8 2.6 0.58 9.7 0.4 2.1 3 0 0 3 3 3 0 E1-E2 ATPase MPP6 PF10175.9 CRG87469.1 - 6.5e-09 36.4 7.5 2.1e-07 31.5 7.5 2.2 1 1 0 1 1 1 1 M-phase phosphoprotein 6 zf-CHCC PF10276.9 CRG87470.1 - 5.9e-16 58.2 1.1 5.9e-16 58.2 1.1 1.7 2 0 0 2 2 2 1 Zinc-finger domain UPF0047 PF01894.17 CRG87471.1 - 1.7e-37 128.1 0.0 1.9e-37 127.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PH PF00169.29 CRG87472.1 - 7.6e-08 32.8 0.7 1.9e-07 31.5 0.7 1.6 1 0 0 1 1 1 1 PH domain FAD-oxidase_C PF02913.19 CRG87473.1 - 2e-56 191.4 0.0 3.3e-56 190.7 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain RmlD_sub_bind PF04321.17 CRG87473.1 - 3.2e-53 180.7 0.0 5.3e-53 180.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain FAD_binding_4 PF01565.23 CRG87473.1 - 5.1e-37 126.7 0.3 1.3e-36 125.4 0.3 1.7 1 0 0 1 1 1 1 FAD binding domain Epimerase PF01370.21 CRG87473.1 - 5.6e-19 68.6 0.0 1.7e-18 67.0 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG87473.1 - 0.0001 21.6 0.2 0.0016 17.6 0.0 2.4 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 CRG87473.1 - 0.00015 21.1 0.0 0.025 13.7 0.0 3.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CRG87473.1 - 0.00018 21.0 0.0 0.00039 19.9 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CRG87473.1 - 0.00036 19.6 0.0 0.0017 17.4 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Pkinase PF00069.25 CRG87474.1 - 1.9e-69 234.0 0.0 2.6e-69 233.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87474.1 - 9e-47 159.5 0.0 1.3e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG87474.1 - 4.3e-06 25.8 0.0 1.1e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 CRG87474.1 - 0.0023 17.3 0.0 0.012 15.0 0.0 2.0 2 0 0 2 2 2 1 Kinase-like ABC1 PF03109.16 CRG87474.1 - 0.05 13.8 0.2 0.15 12.2 0.1 1.9 2 0 0 2 2 2 0 ABC1 family DUF4048 PF13257.6 CRG87475.1 - 4e-78 262.8 19.9 4e-78 262.8 19.9 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4048) Tim17 PF02466.19 CRG87476.1 - 1.5e-36 125.2 7.3 2e-36 124.8 7.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2563 PF10817.8 CRG87476.1 - 0.014 16.0 0.1 0.033 14.8 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2563) PALP PF00291.25 CRG87478.1 - 3.9e-68 230.0 0.2 4.5e-68 229.8 0.2 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cnd3 PF12719.7 CRG87479.1 - 1.9e-91 306.3 0.4 2.2e-90 302.8 0.0 2.4 2 0 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 CRG87479.1 - 0.00012 22.4 10.2 0.065 13.6 3.4 4.6 2 1 2 4 4 4 3 HEAT repeats Cnd1 PF12717.7 CRG87479.1 - 0.0016 18.5 0.3 0.069 13.2 0.1 3.4 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 CRG87479.1 - 0.0095 16.4 5.8 2 9.0 0.5 3.9 4 0 0 4 4 4 2 HEAT-like repeat HEAT PF02985.22 CRG87479.1 - 0.075 13.3 10.2 2.3 8.7 0.0 6.1 7 0 0 7 7 7 0 HEAT repeat Tti2 PF10521.9 CRG87479.1 - 0.14 11.7 0.2 6.3 6.2 0.1 2.8 2 0 0 2 2 2 0 Tti2 family zf-RanBP PF00641.18 CRG87480.1 - 5.7e-21 73.5 10.5 8.5e-11 41.0 1.6 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 CRG87480.1 - 6.3e-08 32.3 0.0 1.4e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNase_T PF00929.24 CRG87480.1 - 1.4e-06 29.0 0.0 2.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Exonuclease zf-ribbon_3 PF13248.6 CRG87480.1 - 0.34 10.4 2.8 2.5 7.6 0.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 CRG87480.1 - 4.6 7.3 7.8 93 3.2 7.9 2.4 1 1 1 2 2 2 0 Double zinc ribbon Proteasome PF00227.26 CRG87481.1 - 8.8e-55 185.1 0.1 1.2e-54 184.7 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CRG87481.1 - 5.9e-13 48.2 0.3 2.1e-12 46.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature HypA PF01155.19 CRG87482.1 - 0.012 15.6 1.6 0.014 15.4 1.6 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-UDP PF14569.6 CRG87482.1 - 0.025 14.7 1.7 0.041 14.0 1.7 1.4 1 0 0 1 1 1 0 Zinc-binding RING-finger Zn-ribbon_8 PF09723.10 CRG87482.1 - 0.11 12.7 6.4 0.16 12.1 6.4 1.3 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 CRG87482.1 - 0.14 12.4 7.2 0.44 10.8 7.2 1.8 1 1 1 2 2 2 0 zinc-ribbon zinc_ribbon_4 PF13717.6 CRG87482.1 - 0.27 11.2 7.1 3.9 7.5 0.1 2.7 3 0 0 3 3 3 0 zinc-ribbon domain Cys_rich_KTR PF14205.6 CRG87482.1 - 3.9 7.4 7.6 43 4.0 7.7 2.0 1 1 1 2 2 2 0 Cysteine-rich KTR WD40 PF00400.32 CRG87483.1 - 6.9e-25 86.8 13.2 0.00092 20.0 0.0 9.6 8 1 1 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87483.1 - 9.5e-13 48.3 4.1 0.072 13.4 0.0 7.1 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG87483.1 - 2.3e-05 23.5 1.5 0.015 14.3 0.2 2.9 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CRG87483.1 - 0.00058 19.8 0.3 0.015 15.2 0.1 2.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CRG87483.1 - 0.0056 15.4 0.1 0.018 13.7 0.1 1.8 1 0 0 1 1 1 1 Nucleoporin Nup120/160 CLTH PF10607.9 CRG87483.1 - 0.01 15.8 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Frtz PF11768.8 CRG87483.1 - 0.028 12.7 0.2 0.11 10.8 0.1 1.8 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 CRG87483.1 - 0.04 14.4 5.7 1.7 9.2 0.2 4.4 5 0 0 5 5 5 0 PQQ-like domain PQQ_2 PF13360.6 CRG87483.1 - 0.046 13.3 1.4 2.3 7.7 0.6 3.5 2 2 0 2 2 2 0 PQQ-like domain Utp8 PF10395.9 CRG87483.1 - 0.065 11.7 0.1 0.15 10.5 0.0 1.5 2 0 0 2 2 2 0 Utp8 family BBS2_Mid PF14783.6 CRG87483.1 - 0.083 12.9 0.2 2.7 8.0 0.0 3.5 4 1 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Mem_trans PF03547.18 CRG87484.1 - 6.8e-14 51.1 1.4 5.5e-13 48.1 0.8 2.1 1 1 1 2 2 2 2 Membrane transport protein Na_Ala_symp PF01235.17 CRG87484.1 - 0.0013 18.1 4.6 0.0023 17.3 0.1 2.5 2 1 1 3 3 3 1 Sodium:alanine symporter family ATP-synt_ab PF00006.25 CRG87485.1 - 6.2e-110 365.9 0.0 1.6e-109 364.5 0.0 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_M PF01031.20 CRG87485.1 - 1e-101 339.9 0.0 2.4e-100 335.4 0.0 2.9 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 CRG87485.1 - 5.5e-56 189.2 0.0 1.2e-55 188.1 0.0 1.6 1 0 0 1 1 1 1 Dynamin family ATP-synt_ab_Xtn PF16886.5 CRG87485.1 - 6.2e-47 158.4 0.0 1.3e-46 157.4 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension GED PF02212.18 CRG87485.1 - 1.1e-30 105.6 7.0 2.6e-30 104.4 7.0 1.7 1 0 0 1 1 1 1 Dynamin GTPase effector domain ATP-synt_ab_N PF02874.23 CRG87485.1 - 1.2e-14 54.6 0.8 2.5e-14 53.5 0.8 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain MMR_HSR1 PF01926.23 CRG87485.1 - 0.0001 22.4 0.2 0.00061 19.9 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG87485.1 - 0.035 14.5 0.1 4.5 7.6 0.0 3.0 2 1 0 2 2 2 0 AAA ATPase domain HSBP1 PF06825.12 CRG87485.1 - 0.052 13.4 0.0 0.15 11.9 0.0 1.8 1 0 0 1 1 1 0 Heat shock factor binding protein 1 DUF2738 PF10927.8 CRG87485.1 - 0.097 11.7 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) CN_hydrolase PF00795.22 CRG87486.1 - 7.8e-37 127.0 0.0 2.9e-36 125.1 0.0 1.8 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase Glyco_hydro_16 PF00722.21 CRG87487.1 - 6.8e-08 32.2 0.1 1.1e-07 31.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TPPII_N PF12583.8 CRG87487.1 - 0.15 12.7 0.8 0.38 11.3 0.8 1.6 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal PRT_C PF08372.10 CRG87488.1 - 0.0054 16.5 0.6 0.065 13.0 0.2 2.3 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal Reticulon PF02453.17 CRG87488.1 - 0.072 13.0 7.0 0.96 9.4 2.9 2.2 2 0 0 2 2 2 0 Reticulon KleE PF17394.2 CRG87488.1 - 2.4 8.4 9.4 1.2 9.4 0.5 2.9 2 1 1 3 3 3 0 Uncharacterized KleE stable inheritance protein PEP_mutase PF13714.6 CRG87489.1 - 8.4e-40 136.7 3.5 1.6e-39 135.8 3.5 1.4 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 CRG87489.1 - 1.2e-15 57.0 0.2 1.9e-15 56.4 0.2 1.3 1 0 0 1 1 1 1 Isocitrate lyase family Fungal_trans PF04082.18 CRG87489.1 - 9.6e-05 21.5 0.9 9.6e-05 21.5 0.9 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain ADH_N PF08240.12 CRG87490.1 - 0.00025 20.9 0.0 0.00061 19.6 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG87490.1 - 0.0025 17.8 0.1 0.0049 16.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DIOX_N PF14226.6 CRG87491.1 - 2e-15 57.6 0.0 3.8e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG87491.1 - 6.6e-13 49.0 0.0 1.6e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily APH PF01636.23 CRG87492.1 - 1.5e-13 51.3 0.0 1.1e-12 48.4 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG87492.1 - 0.0013 18.4 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 CRG87492.1 - 0.0017 17.8 0.0 0.067 12.5 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain DUF1679 PF07914.11 CRG87492.1 - 0.0088 14.9 0.0 0.052 12.4 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1679) EcKinase PF02958.20 CRG87492.1 - 0.012 14.9 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase TrkH PF02386.16 CRG87493.1 - 1.3e-151 505.5 2.5 1.3e-151 505.5 2.5 2.2 2 0 0 2 2 2 2 Cation transport protein Ank_4 PF13637.6 CRG87493.1 - 1.3e-41 140.4 1.2 3.7e-12 46.5 0.0 6.9 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG87493.1 - 2.3e-41 138.5 1.5 9.2e-07 29.0 0.0 8.0 7 0 0 7 7 7 7 Ankyrin repeat Ank_2 PF12796.7 CRG87493.1 - 1.4e-38 131.3 1.2 3.2e-11 43.7 0.2 4.5 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG87493.1 - 7.4e-36 118.1 1.5 9.4e-05 22.5 0.0 8.0 7 0 0 7 7 7 7 Ankyrin repeat Ank_5 PF13857.6 CRG87493.1 - 1.8e-33 114.1 1.5 3.2e-09 36.9 0.1 5.2 3 1 1 5 5 5 5 Ankyrin repeats (many copies) MFS_1 PF07690.16 CRG87493.1 - 6.4e-29 101.0 65.6 2.4e-17 62.9 24.3 3.8 2 2 1 3 3 3 2 Major Facilitator Superfamily NPP1 PF05630.11 CRG87494.1 - 0.00036 20.7 3.0 0.0049 17.0 3.0 2.3 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) GST_N_2 PF13409.6 CRG87495.1 - 4.5e-07 30.1 0.0 1.3e-06 28.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG87495.1 - 1.6e-06 28.3 0.0 4.6e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CRG87495.1 - 3.9e-06 27.2 0.1 8.3e-06 26.1 0.1 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG87495.1 - 0.0016 18.4 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GFA PF04828.14 CRG87496.1 - 3.9e-09 36.7 2.8 3.9e-09 36.7 2.8 2.0 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme F-box-like PF12937.7 CRG87497.1 - 8.8e-07 28.7 0.5 3e-06 27.0 0.5 2.0 1 1 0 1 1 1 1 F-box-like Melibiase_2 PF16499.5 CRG87498.1 - 1.4e-56 191.8 5.8 1.5e-37 129.4 0.3 2.3 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 CRG87498.1 - 3.6e-14 52.6 1.6 1.6e-12 47.3 0.1 3.0 3 0 0 3 3 3 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 CRG87498.1 - 4.2e-07 29.2 0.1 9.2e-07 28.1 0.0 1.5 2 0 0 2 2 2 1 Melibiase Raffinose_syn PF05691.12 CRG87498.1 - 0.063 11.1 0.0 0.091 10.5 0.0 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 DEAD PF00270.29 CRG87499.1 - 1.9e-41 141.8 0.1 3.3e-41 141.0 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG87499.1 - 1.4e-33 115.6 0.1 6.5e-33 113.4 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 CRG87499.1 - 0.0012 18.6 0.0 0.0018 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG87499.1 - 0.0018 18.6 0.0 0.016 15.5 0.1 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 CRG87499.1 - 0.0032 17.5 0.0 0.0062 16.6 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Flavi_DEAD PF07652.14 CRG87499.1 - 0.032 14.2 0.4 0.13 12.3 0.1 2.3 1 1 0 2 2 2 0 Flavivirus DEAD domain TniB PF05621.11 CRG87499.1 - 0.06 12.8 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Helicase_RecD PF05127.14 CRG87499.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 CRG87499.1 - 0.23 11.8 1.1 1.1 9.6 1.1 2.0 1 1 0 1 1 1 0 AAA domain DUF3449 PF11931.8 CRG87500.1 - 1.4e-74 249.9 0.5 4.3e-74 248.3 0.5 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 CRG87500.1 - 1.8e-23 82.8 0.3 1.8e-23 82.8 0.3 2.0 2 0 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 DNA_ligase_A_M PF01068.21 CRG87500.1 - 7.9e-21 74.6 0.0 1.6e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CRG87500.1 - 4.7e-18 66.1 0.0 1.3e-17 64.7 0.0 1.7 1 0 0 1 1 1 1 DNA ligase N terminus SF3a60_bindingd PF12108.8 CRG87500.1 - 9.8e-16 57.3 2.0 2.6e-15 56.0 2.0 1.8 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_jaz PF12171.8 CRG87500.1 - 9.4e-08 32.2 2.7 1.2e-07 31.8 1.0 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG87500.1 - 2e-07 31.1 2.1 2.8e-06 27.5 1.0 2.6 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CRG87500.1 - 0.0029 17.9 0.5 0.027 14.8 0.1 2.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) PRP9_N PF16958.5 CRG87500.1 - 0.0035 17.4 3.6 0.68 10.0 0.3 3.1 1 1 1 2 2 2 2 Pre-mRNA-splicing factor PRP9 N-terminus zf-LYAR PF08790.11 CRG87500.1 - 0.52 10.3 2.3 0.74 9.8 0.2 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger ANAPC8 PF04049.13 CRG87501.1 - 2.4e-54 183.2 0.0 4.6e-54 182.3 0.0 1.5 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 CRG87501.1 - 7.7e-20 69.4 9.8 1.7e-05 24.7 0.0 7.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 CRG87501.1 - 5.4e-19 67.1 5.7 0.00017 21.2 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 CRG87501.1 - 3.6e-15 54.8 17.4 0.058 13.5 2.8 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 CRG87501.1 - 1.2e-09 38.1 16.7 0.0067 17.2 0.0 8.3 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG87501.1 - 5.9e-09 35.5 1.2 1e-06 28.3 0.3 3.5 2 1 1 3 3 3 1 TPR repeat TPR_16 PF13432.6 CRG87501.1 - 2.2e-07 31.4 13.3 1.6e-05 25.4 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG87501.1 - 4.1e-06 26.4 10.5 0.0076 16.2 0.1 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG87501.1 - 5.8e-06 26.7 16.6 0.13 12.8 0.0 7.8 8 2 1 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG87501.1 - 1.2e-05 25.3 6.9 3.7 8.1 0.1 5.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 CRG87501.1 - 0.00028 21.1 16.5 0.18 12.1 1.0 5.6 4 1 1 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG87501.1 - 0.00036 20.7 13.1 0.18 12.0 0.3 5.3 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CRG87501.1 - 0.0011 19.0 5.6 1.2 9.3 0.1 4.3 3 1 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CRG87501.1 - 0.0037 17.8 23.7 2.1 9.2 0.3 8.4 8 1 0 8 8 7 1 Tetratricopeptide repeat TPR_15 PF13429.6 CRG87501.1 - 0.0077 15.5 2.0 0.0077 15.5 2.0 3.3 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF4178 PF13785.6 CRG87501.1 - 0.0083 16.2 0.2 0.14 12.3 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4178) TPR_10 PF13374.6 CRG87501.1 - 0.036 13.9 7.6 0.68 9.9 0.3 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.10 CRG87501.1 - 0.089 11.8 0.6 5.1 6.0 0.0 2.9 1 1 2 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Sel1 PF08238.12 CRG87501.1 - 2.4 8.9 8.2 47 4.9 0.9 4.6 4 0 0 4 4 3 0 Sel1 repeat polyprenyl_synt PF00348.17 CRG87502.1 - 1.8e-89 299.2 0.0 2.2e-89 298.9 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase RNase_H2-Ydr279 PF09468.10 CRG87502.1 - 0.063 13.5 0.6 0.21 11.7 0.2 2.0 2 1 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain ADH_zinc_N PF00107.26 CRG87503.1 - 3.1e-16 59.5 0.1 9.7e-16 57.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG87503.1 - 5.3e-15 56.6 0.0 1.1e-14 55.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG87503.1 - 2.8e-09 36.8 0.6 4.7e-06 26.5 0.0 3.4 2 1 1 3 3 3 2 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CRG87503.1 - 0.00092 18.6 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_N_2 PF16884.5 CRG87503.1 - 0.0029 17.5 0.1 0.0085 16.0 0.0 1.7 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase Glu_dehyd_C PF16912.5 CRG87503.1 - 0.012 15.2 0.0 0.023 14.2 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Stanniocalcin PF03298.13 CRG87504.1 - 0.0041 16.5 0.0 0.0045 16.3 0.0 1.1 1 0 0 1 1 1 1 Stanniocalcin family Toxin_22 PF08092.11 CRG87504.1 - 1 9.5 7.1 3.2 7.9 7.1 1.9 1 1 0 1 1 1 0 Magi peptide toxin family Glycogen_syn PF05693.13 CRG87505.1 - 0 1148.1 0.0 0 1147.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 CRG87505.1 - 1.3e-05 25.3 0.2 2.8e-05 24.2 0.2 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 CRG87505.1 - 3.6e-05 24.3 0.0 8.3e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_5 PF08323.11 CRG87505.1 - 0.00017 21.3 0.5 0.00033 20.4 0.1 1.7 2 0 0 2 2 2 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 CRG87505.1 - 0.0003 21.2 0.0 0.072 13.5 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 CRG87505.1 - 0.00057 19.5 0.0 0.0066 16.0 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 NMT1 PF09084.11 CRG87506.1 - 1.3e-73 247.5 0.0 2.6e-72 243.2 0.0 2.1 1 1 0 1 1 1 1 NMT1/THI5 like NMT1_2 PF13379.6 CRG87506.1 - 0.00017 21.4 0.1 0.1 12.3 0.0 3.6 3 1 1 4 4 4 1 NMT1-like family PBP_like PF12727.7 CRG87506.1 - 0.16 11.1 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 0 PBP superfamily domain Vps54 PF07928.12 CRG87508.1 - 1.3e-52 177.7 0.6 3.8e-52 176.3 0.6 1.9 1 0 0 1 1 1 1 Vps54-like protein Vps54_N PF10475.9 CRG87508.1 - 1.2e-07 31.3 0.9 1.2e-07 31.3 0.9 2.4 3 0 0 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 CRG87508.1 - 0.0001 22.2 0.1 0.00068 19.5 0.1 2.2 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) FliJ PF02050.16 CRG87508.1 - 0.1 12.8 0.1 0.1 12.8 0.1 2.5 3 0 0 3 3 3 0 Flagellar FliJ protein ArAE_2_N PF10337.9 CRG87508.1 - 0.17 10.9 0.7 0.4 9.6 0.0 1.9 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal DUF4363 PF14276.6 CRG87508.1 - 0.39 10.9 3.8 1.4 9.0 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4363) Cytochrom_B562 PF07361.11 CRG87508.1 - 1.5 9.6 5.0 2 9.1 0.5 3.7 4 2 1 5 5 5 0 Cytochrome b562 MerB PF03243.15 CRG87509.1 - 8.5e-21 74.4 0.0 1.1e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Alkylmercury lyase Methyltransf_23 PF13489.6 CRG87510.1 - 8.4e-06 25.7 0.0 1.2e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87510.1 - 1e-05 26.2 0.0 3e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87510.1 - 2e-05 24.4 0.0 0.00011 22.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87510.1 - 0.00013 22.6 0.0 0.00028 21.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87510.1 - 0.0013 19.4 0.0 0.0037 17.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG87510.1 - 0.099 12.1 0.0 7.1 6.1 0.0 2.7 2 1 1 3 3 3 0 Putative methyltransferase a_DG1_N2 PF18424.1 CRG87510.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Alpha-Dystroglycan N-terminal domain 2 FAD_binding_4 PF01565.23 CRG87511.1 - 7.6e-21 74.3 1.3 7.6e-21 74.3 1.3 1.9 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CRG87511.1 - 1.1e-12 47.9 1.2 3.2e-12 46.4 1.1 1.9 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.10 CRG87511.1 - 0.03 13.7 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding Abhydrolase_6 PF12697.7 CRG87512.1 - 3.5e-14 54.0 0.1 4.3e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG87512.1 - 0.0043 16.7 0.1 0.0073 16.0 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 CRG87512.1 - 0.036 13.8 0.1 0.061 13.0 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Lipase_2 PF01674.18 CRG87512.1 - 0.049 13.1 0.0 0.077 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipase (class 2) Abhydrolase_8 PF06259.12 CRG87512.1 - 0.054 13.1 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase DUF900 PF05990.12 CRG87512.1 - 0.17 11.4 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Methyltransf_23 PF13489.6 CRG87513.1 - 4.4e-08 33.1 0.0 6.7e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87513.1 - 3e-06 27.8 0.0 7.1e-06 26.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87513.1 - 4.2e-06 26.6 0.0 2.7e-05 24.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87513.1 - 0.00072 20.2 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87513.1 - 0.0015 19.1 0.0 0.0047 17.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CheR PF01739.18 CRG87513.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Epimerase PF01370.21 CRG87515.1 - 4.4e-13 49.2 0.0 6.4e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG87515.1 - 2.5e-08 33.3 0.0 3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG87515.1 - 5.7e-08 32.9 0.0 1.3e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CRG87515.1 - 5.6e-06 26.0 0.0 0.087 12.3 0.0 2.6 3 0 0 3 3 3 2 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 CRG87515.1 - 9.8e-06 25.2 0.0 1.2e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CRG87515.1 - 1.5e-05 24.7 0.0 2.7e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 NmrA-like family Polysacc_synt_2 PF02719.15 CRG87515.1 - 0.0005 19.3 0.0 0.00066 18.9 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CRG87515.1 - 0.0032 16.7 0.0 0.043 13.0 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein YfmQ PF10787.9 CRG87515.1 - 0.044 13.5 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein from bacillus cereus group p450 PF00067.22 CRG87516.1 - 1.5e-56 192.1 0.0 1.9e-56 191.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CRG87517.1 - 2e-64 218.1 0.0 2.2e-64 217.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Trp_DMAT PF11991.8 CRG87518.1 - 9.2e-93 311.5 0.0 1.1e-92 311.3 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase Lyase_aromatic PF00221.19 CRG87519.1 - 2.8e-149 497.7 0.4 3.8e-149 497.3 0.4 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase Abhydrolase_6 PF12697.7 CRG87520.1 - 9.3e-15 55.8 0.6 1.1e-14 55.6 0.6 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG87520.1 - 0.12 11.7 0.0 0.62 9.3 0.0 2.1 2 1 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_9_N PF15420.6 CRG87521.1 - 3.1 7.7 11.4 1.1 9.2 0.4 2.2 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus MCM PF00493.23 CRG87522.1 - 3.4e-104 346.8 0.1 1.1e-103 345.1 0.0 1.8 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 CRG87522.1 - 2.8e-36 124.2 0.3 5.5e-36 123.2 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CRG87522.1 - 4.8e-28 97.4 1.9 1.2e-27 96.1 1.9 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CRG87522.1 - 9.5e-16 58.3 0.3 2.3e-15 57.0 0.3 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CRG87522.1 - 8e-07 28.6 0.0 0.00059 19.3 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CRG87522.1 - 6.7e-05 22.9 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 CRG87522.1 - 0.0015 18.4 0.0 0.0046 16.8 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CRG87522.1 - 0.037 13.7 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain PfkB PF00294.24 CRG87523.1 - 2.2e-32 112.6 0.3 3e-31 108.8 0.3 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase 3HCDH_RFF PF18321.1 CRG87523.1 - 0.09 13.2 0.2 5 7.7 0.2 2.7 2 0 0 2 2 2 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Tau95 PF09734.9 CRG87525.1 - 3.2e-41 141.4 2.0 7.3e-41 140.3 0.3 2.3 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 CRG87525.1 - 6.6e-38 129.8 0.0 1.6e-37 128.5 0.0 1.7 1 0 0 1 1 1 1 Tau95 Triple barrel domain Sporozoite_P67 PF05642.11 CRG87525.1 - 0.12 10.5 6.7 0.18 9.9 6.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 CRG87525.1 - 0.25 9.5 15.5 0.36 9.0 15.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 CRG87525.1 - 2.4 7.2 23.1 4.6 6.3 23.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SGT1 PF07093.11 CRG87525.1 - 7.1 4.9 10.2 11 4.4 10.2 1.1 1 0 0 1 1 1 0 SGT1 protein NOA36 PF06524.12 CRG87525.1 - 7.7 5.7 16.8 13 5.0 16.8 1.2 1 0 0 1 1 1 0 NOA36 protein B56 PF01603.20 CRG87526.1 - 5e-192 638.4 4.9 6.1e-192 638.2 4.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) FAM199X PF15814.5 CRG87526.1 - 4.3 6.3 10.9 10 5.0 9.6 2.1 2 0 0 2 2 2 0 Protein family FAM199X DUF4229 PF14012.6 CRG87527.1 - 0.0027 17.7 3.9 0.0027 17.7 3.9 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) Fumarate_red_D PF02313.17 CRG87527.1 - 0.47 10.6 3.4 0.94 9.6 0.2 2.7 3 0 0 3 3 3 0 Fumarate reductase subunit D FAT PF02259.23 CRG87528.1 - 1.1e-75 255.0 7.8 6.1e-75 252.6 7.7 2.2 2 0 0 2 2 2 1 FAT domain AAA PF00004.29 CRG87528.1 - 5.1e-51 172.5 0.0 6.5e-38 130.1 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) PI3_PI4_kinase PF00454.27 CRG87528.1 - 5.2e-38 131.3 0.1 1.8e-37 129.5 0.1 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase AAA_lid_3 PF17862.1 CRG87528.1 - 1.2e-08 34.6 0.1 3.5e-08 33.1 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_33 PF13671.6 CRG87528.1 - 2.5e-07 30.9 0.0 0.019 15.2 0.0 4.0 4 0 0 4 4 3 2 AAA domain CDC48_2 PF02933.17 CRG87528.1 - 4.8e-07 29.5 0.2 2.5e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_2 PF07724.14 CRG87528.1 - 9.4e-07 29.1 0.2 0.0002 21.5 0.0 3.3 2 1 1 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 CRG87528.1 - 1.3e-06 28.7 0.0 0.00079 19.7 0.0 4.1 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CRG87528.1 - 2.4e-06 28.0 2.2 0.012 16.0 0.0 4.1 4 1 0 4 4 3 2 AAA ATPase domain FATC PF02260.20 CRG87528.1 - 0.00011 22.0 0.1 0.00027 20.7 0.1 1.8 1 0 0 1 1 1 1 FATC domain AAA_14 PF13173.6 CRG87528.1 - 0.00022 21.3 0.0 1.2 9.2 0.0 2.9 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 CRG87528.1 - 0.00033 20.0 0.1 0.12 11.6 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain Mg_chelatase PF01078.21 CRG87528.1 - 0.00043 19.7 0.3 0.033 13.6 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 CRG87528.1 - 0.0013 19.1 0.0 0.37 11.2 0.0 3.1 2 0 0 2 2 2 1 RNA helicase RuvB_N PF05496.12 CRG87528.1 - 0.0019 18.0 0.1 0.27 11.0 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 CRG87528.1 - 0.0021 17.8 0.1 0.057 13.1 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 CRG87528.1 - 0.003 17.6 0.0 0.015 15.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CRG87528.1 - 0.0057 17.2 0.0 0.35 11.4 0.0 3.3 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 CRG87528.1 - 0.011 15.2 0.0 0.2 11.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 CRG87528.1 - 0.032 13.6 0.6 0.14 11.5 0.1 2.3 2 0 0 2 2 2 0 KaiC CDC48_N PF02359.18 CRG87528.1 - 0.035 14.3 0.0 0.088 13.0 0.0 1.8 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain ATPase_2 PF01637.18 CRG87528.1 - 0.036 14.0 0.5 65 3.3 0.2 4.0 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CRG87528.1 - 0.041 14.4 0.3 0.25 11.9 0.1 2.5 2 0 0 2 2 1 0 ABC transporter IstB_IS21 PF01695.17 CRG87528.1 - 0.044 13.5 0.0 0.33 10.7 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 CRG87528.1 - 0.047 13.7 0.0 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CRG87528.1 - 0.077 13.2 0.0 1.7 8.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain TPR_2 PF07719.17 CRG87528.1 - 0.43 10.8 3.0 8.6 6.7 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TFIIA PF03153.13 CRG87528.1 - 5.3 6.9 42.5 6.3 6.7 35.2 2.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF572 PF04502.13 CRG87529.1 - 3.3e-72 243.9 12.8 3.8e-72 243.7 12.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Zn_ribbon_SprT PF17283.2 CRG87529.1 - 0.69 9.9 3.7 0.71 9.8 2.2 1.8 1 1 0 1 1 1 0 SprT-like zinc ribbon domain DUF2894 PF11445.8 CRG87529.1 - 3.5 8.1 10.8 6.7 7.1 10.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) TF_Zn_Ribbon PF08271.12 CRG87529.1 - 7.2 6.2 9.4 2.5 7.7 1.3 2.9 3 0 0 3 3 3 0 TFIIB zinc-binding TPR_1 PF00515.28 CRG87530.1 - 5.3e-29 98.8 5.6 7.1e-05 22.5 0.8 9.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 CRG87530.1 - 6.7e-27 91.4 18.2 0.00066 19.6 0.4 10.2 10 0 0 10 10 10 7 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG87530.1 - 4e-26 91.1 15.5 1.4e-20 73.3 1.2 6.2 6 0 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CRG87530.1 - 1.3e-17 62.4 8.6 0.027 14.7 0.1 8.9 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 CRG87530.1 - 2.1e-17 63.4 13.5 0.00047 20.6 0.1 7.4 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 CRG87530.1 - 1.1e-16 60.9 28.9 1.7e-07 31.4 0.3 9.4 7 3 1 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 CRG87530.1 - 4.2e-13 48.9 17.4 2.5 9.2 0.3 9.3 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 CRG87530.1 - 3.8e-12 46.7 21.2 0.38 11.4 0.1 8.8 8 1 2 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 CRG87530.1 - 1.3e-11 43.9 2.0 0.37 10.5 0.1 7.8 8 0 0 8 8 8 3 TPR repeat TPR_10 PF13374.6 CRG87530.1 - 9.5e-10 38.0 19.2 0.00043 20.0 0.1 7.2 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG87530.1 - 5.6e-08 32.3 21.2 0.49 10.5 0.3 9.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 CRG87530.1 - 1.2e-07 31.9 15.1 0.31 11.8 0.3 8.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG87530.1 - 0.00018 21.7 15.3 2.7 8.6 0.0 8.1 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_21 PF09976.9 CRG87530.1 - 0.00046 20.0 1.5 4 7.1 0.0 4.6 5 1 0 5 5 5 1 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 CRG87530.1 - 0.0093 16.0 0.1 0.09 12.8 0.0 2.4 2 0 0 2 2 2 1 Putative TPR-like repeat TPR_4 PF07721.14 CRG87530.1 - 0.042 14.5 18.5 0.44 11.3 0.2 7.8 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG87530.1 - 0.24 10.7 15.7 0.48 9.7 0.0 4.2 4 1 1 5 5 5 0 MalT-like TPR region DDE_1 PF03184.19 CRG87531.1 - 5e-28 97.9 0.0 1.1e-27 96.8 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_ABP1_N PF18107.1 CRG87531.1 - 2.9e-27 94.1 2.4 1.1e-26 92.4 2.4 2.0 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 CRG87531.1 - 5.8e-16 58.3 0.1 2.2e-15 56.4 0.1 2.1 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain Fungal_trans PF04082.18 CRG87532.1 - 6.9e-10 38.4 0.8 1.3e-09 37.5 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87532.1 - 4.2e-06 26.8 12.2 4.2e-06 26.8 12.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG87533.1 - 9.5e-46 156.3 30.6 1.1e-45 156.1 25.3 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG87533.1 - 2.3e-11 42.9 2.5 3.5e-11 42.3 2.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG87533.1 - 4e-10 39.2 16.4 8e-10 38.2 16.4 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter FPN1 PF06963.12 CRG87533.1 - 0.039 12.5 0.0 0.096 11.2 0.0 1.6 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF2178 PF09946.9 CRG87533.1 - 0.082 13.1 5.9 0.16 12.1 0.3 3.3 3 0 0 3 3 3 0 Predicted membrane protein (DUF2178) TMCO5 PF14992.6 CRG87533.1 - 0.2 11.2 0.3 0.32 10.5 0.3 1.2 1 0 0 1 1 1 0 TMCO5 family GATase_5 PF13507.6 CRG87534.1 - 4.5e-100 334.0 0.0 6.7e-100 333.5 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 CRG87534.1 - 2.2e-38 131.8 0.4 2.4e-23 83.0 0.4 2.5 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 CRG87534.1 - 4e-35 120.3 0.0 8.9e-35 119.2 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 CRG87534.1 - 1.4e-21 76.8 0.0 3.1e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain GCP_N_terminal PF17681.1 CRG87535.1 - 1.6e-32 113.3 0.8 1.6e-32 113.3 0.8 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 CRG87535.1 - 3.4e-26 92.4 0.3 8.2e-26 91.2 0.1 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 CRG87535.1 - 0.00034 19.1 0.0 0.00053 18.5 0.0 1.4 1 0 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 Glyco_transf_15 PF01793.16 CRG87536.1 - 4.5e-115 384.4 11.4 5.6e-115 384.0 11.4 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase COX5A PF02284.16 CRG87537.1 - 2.6e-39 133.4 0.6 3.2e-39 133.1 0.6 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va ELO PF01151.18 CRG87538.1 - 2.9e-60 203.9 26.7 3.4e-60 203.7 26.7 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family adh_short PF00106.25 CRG87540.1 - 3e-06 26.8 0.0 0.0041 16.6 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87540.1 - 0.00012 21.7 0.0 0.053 13.1 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PNTB PF02233.16 CRG87541.1 - 9.3e-173 575.4 26.5 9.3e-173 575.4 26.5 2.0 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 CRG87541.1 - 3e-74 248.9 0.1 3e-74 248.9 0.1 2.9 5 0 0 5 5 5 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 CRG87541.1 - 3.6e-45 153.6 0.1 7.9e-45 152.5 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 CRG87541.1 - 2.7e-30 104.7 3.3 2.7e-30 104.7 3.3 4.7 4 1 1 5 5 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 CRG87541.1 - 0.00067 19.1 0.2 1.2 8.5 0.0 3.1 3 0 0 3 3 3 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 CRG87541.1 - 0.0055 16.0 0.4 0.013 14.8 0.1 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase PRIMA1 PF16101.5 CRG87541.1 - 0.014 15.5 1.4 0.053 13.6 1.4 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NAD_binding_2 PF03446.15 CRG87541.1 - 0.036 14.2 2.2 0.27 11.4 0.2 2.8 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase TPP_enzyme_M PF00205.22 CRG87541.1 - 0.037 13.8 0.4 0.17 11.6 0.4 2.2 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain NAD_binding_8 PF13450.6 CRG87541.1 - 0.046 14.0 0.4 0.046 14.0 0.4 2.6 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain ArabFuran-catal PF09206.11 CRG87542.1 - 1.1e-149 498.0 16.3 1.4e-149 497.7 16.3 1.1 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 CRG87542.1 - 7.6e-56 188.0 1.0 1.2e-55 187.4 1.0 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Glyco_hydro_127 PF07944.12 CRG87544.1 - 2.3e-20 72.6 0.0 3.6e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 AA_permease_2 PF13520.6 CRG87545.1 - 2.3e-42 145.3 52.0 2.9e-42 145.0 52.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG87545.1 - 3e-18 65.7 39.2 4.7e-18 65.0 39.2 1.2 1 0 0 1 1 1 1 Amino acid permease Pyr_redox_2 PF07992.14 CRG87546.1 - 3.6e-38 131.5 0.2 4.5e-38 131.2 0.2 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG87546.1 - 1.8e-11 44.4 0.5 3.4e-09 37.1 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG87546.1 - 7.5e-08 31.8 2.3 0.0036 16.4 0.0 2.4 3 0 0 3 3 3 2 Lycopene cyclase protein Thi4 PF01946.17 CRG87546.1 - 1.1e-06 28.0 0.1 0.03 13.6 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Pyr_redox_3 PF13738.6 CRG87546.1 - 1.9e-06 27.4 0.7 0.00012 21.4 0.1 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG87546.1 - 0.00012 21.4 0.2 0.034 13.3 0.0 2.5 1 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG87546.1 - 0.00032 20.4 3.4 2.4 7.6 0.1 3.9 4 0 0 4 4 4 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG87546.1 - 0.0017 18.4 4.3 16 5.5 0.3 4.1 3 1 0 4 4 4 0 FAD-NAD(P)-binding AdoHcyase_NAD PF00670.21 CRG87546.1 - 0.0052 16.9 2.7 0.21 11.7 0.1 2.8 2 1 1 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain TrkA_N PF02254.18 CRG87546.1 - 0.0053 17.0 0.3 1 9.6 0.1 2.6 2 0 0 2 2 2 1 TrkA-N domain Semialdhyde_dh PF01118.24 CRG87546.1 - 0.013 16.0 0.8 0.13 12.7 0.1 2.6 2 1 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CRG87546.1 - 0.016 15.4 0.0 5.3 7.4 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 CRG87546.1 - 0.03 14.7 0.3 4.7 7.7 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding ApbA PF02558.16 CRG87546.1 - 0.043 13.5 0.2 0.11 12.1 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 CRG87546.1 - 0.051 13.6 0.4 61 3.7 0.0 3.4 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG87546.1 - 0.084 13.1 0.1 0.5 10.6 0.1 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_4 PF01565.23 CRG87547.1 - 3.2e-21 75.5 0.0 4.8e-21 75.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG87547.1 - 8.9e-07 28.9 0.4 1.1e-05 25.5 0.1 2.4 2 0 0 2 2 2 1 Berberine and berberine like Asp PF00026.23 CRG87548.1 - 4.3e-39 134.8 0.0 5.3e-39 134.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease gag-asp_proteas PF13975.6 CRG87548.1 - 8e-05 23.1 0.0 0.023 15.3 0.0 2.8 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CRG87548.1 - 9.9e-05 22.9 0.0 0.0087 16.7 0.0 3.0 2 1 0 2 2 2 1 Aspartyl protease TAXi_N PF14543.6 CRG87548.1 - 0.11 12.8 0.3 17 5.6 0.0 2.8 3 1 0 3 3 3 0 Xylanase inhibitor N-terminal FAD_binding_3 PF01494.19 CRG87549.1 - 7.7e-72 242.5 0.0 8.2e-51 173.3 0.0 3.1 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG87549.1 - 4.2e-09 36.5 0.6 0.0014 18.8 0.1 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG87549.1 - 1.1e-08 35.0 1.0 0.0039 16.8 0.6 3.3 3 0 0 3 3 3 3 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG87549.1 - 1.4e-08 33.9 0.9 7.9e-05 21.5 0.2 3.0 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox_2 PF07992.14 CRG87549.1 - 1.7e-08 34.1 1.0 0.0085 15.4 0.0 3.3 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG87549.1 - 2.4e-08 33.6 4.3 0.0052 16.1 0.3 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG87549.1 - 2e-07 31.5 0.8 0.026 15.1 0.2 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG87549.1 - 9.8e-07 28.2 0.2 0.028 13.7 0.0 2.2 2 0 0 2 2 2 2 Thi4 family Lycopene_cycl PF05834.12 CRG87549.1 - 1.2e-06 27.8 3.3 0.011 14.8 0.2 3.4 3 1 0 3 3 3 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 CRG87549.1 - 9.1e-06 25.0 2.4 0.044 12.9 0.7 3.1 2 1 1 3 3 3 2 FAD binding domain SE PF08491.10 CRG87549.1 - 7.3e-05 21.9 0.0 0.015 14.4 0.0 2.5 3 0 0 3 3 3 1 Squalene epoxidase ApbA PF02558.16 CRG87549.1 - 0.00017 21.2 0.4 0.31 10.7 0.0 2.4 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 CRG87549.1 - 0.00062 19.7 1.1 0.023 14.6 0.2 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CRG87549.1 - 0.0017 18.0 1.5 0.068 12.7 0.2 2.5 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CRG87549.1 - 0.0025 18.1 0.9 0.54 10.5 0.3 2.5 2 0 0 2 2 2 1 TrkA-N domain XdhC_C PF13478.6 CRG87549.1 - 0.003 18.0 0.1 0.68 10.4 0.1 2.5 2 0 0 2 2 2 1 XdhC Rossmann domain Glu_dehyd_C PF16912.5 CRG87549.1 - 0.0037 16.8 0.0 0.49 9.8 0.0 2.3 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus Trp_halogenase PF04820.14 CRG87549.1 - 0.043 12.7 1.3 3 6.6 0.3 2.9 4 0 0 4 4 4 0 Tryptophan halogenase GIDA PF01134.22 CRG87549.1 - 0.051 12.7 0.6 0.55 9.2 0.3 2.3 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 CRG87549.1 - 0.062 13.3 1.8 2.6 8.0 0.1 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 CRG87549.1 - 0.067 13.6 0.3 0.69 10.4 0.1 2.5 2 1 0 2 2 2 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 CRG87549.1 - 0.091 12.1 0.2 7 6.0 0.1 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 CRG87549.1 - 2.3 7.4 3.4 23 4.2 0.7 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase DLH PF01738.18 CRG87550.1 - 1.7e-21 76.8 0.0 1.9e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Fungal_trans PF04082.18 CRG87551.1 - 6e-14 51.7 0.4 8.5e-14 51.2 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain DIOX_N PF14226.6 CRG87552.1 - 5.6e-30 104.5 0.0 3.9e-29 101.8 0.0 2.3 2 1 1 3 3 3 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG87552.1 - 3.2e-13 50.0 0.0 6.4e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF4614 PF15391.6 CRG87552.1 - 0.022 14.8 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Aldo_ket_red PF00248.21 CRG87553.1 - 3.7e-70 236.4 0.0 4.2e-70 236.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Phage_ABA_S PF18066.1 CRG87553.1 - 0.045 14.5 0.1 0.16 12.7 0.0 1.9 2 0 0 2 2 2 0 Phage ABA sandwich domain DUF1996 PF09362.10 CRG87554.1 - 5.9e-79 265.4 0.8 7.6e-79 265.0 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF3012 PF11216.8 CRG87554.1 - 0.12 12.4 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) Asparaginase PF00710.20 CRG87555.1 - 1.9e-58 197.2 0.0 2.7e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 CRG87555.1 - 4.7e-27 94.5 0.4 1.2e-26 93.2 0.4 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 CRG87555.1 - 2.8e-17 63.1 0.1 4.7e-10 39.9 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG87555.1 - 5.8e-10 39.5 0.1 9.1e-06 26.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG87555.1 - 9.5e-09 34.8 0.4 0.01 16.3 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 CRG87555.1 - 1.2e-07 31.9 0.7 0.00045 20.5 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 CRG87555.1 - 1.6e-06 28.3 0.0 1.3e-05 25.4 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) NmrA PF05368.13 CRG87556.1 - 7.9e-72 241.6 0.0 9.8e-72 241.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family DUF1876 PF08962.11 CRG87556.1 - 0.063 13.3 0.2 0.14 12.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1876) NAP PF00956.18 CRG87557.1 - 5.6e-26 91.3 12.1 9.9e-25 87.2 5.9 2.2 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) Syntaxin-6_N PF09177.11 CRG87558.1 - 5.7e-26 91.0 5.0 6.5e-26 90.8 0.1 2.4 1 1 1 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 CRG87558.1 - 4.6e-05 23.3 0.6 9.6e-05 22.3 0.6 1.6 1 0 0 1 1 1 1 SNARE domain Peptidase_M75 PF09375.10 CRG87558.1 - 0.014 14.9 0.2 0.023 14.1 0.2 1.3 1 0 0 1 1 1 0 Imelysin THOC7 PF05615.13 CRG87558.1 - 0.034 14.4 1.0 0.034 14.4 1.0 1.7 2 0 0 2 2 2 0 Tho complex subunit 7 DUF5132 PF17195.4 CRG87558.1 - 1.5 9.0 3.8 14 5.9 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) LST1 PF05083.13 CRG87559.1 - 1.5 9.1 3.8 0.58 10.5 0.6 1.9 2 0 0 2 2 2 0 LST-1 protein Methyltransf_32 PF13679.6 CRG87560.1 - 1.5e-23 83.6 0.5 3.7e-23 82.2 0.5 1.7 1 1 0 1 1 1 1 Methyltransferase domain Med1 PF10744.9 CRG87562.1 - 5.4e-122 407.8 0.0 1e-121 406.9 0.0 1.4 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 NupH_GANP PF16768.5 CRG87562.1 - 0.093 12.4 10.8 1.3 8.6 5.9 2.3 1 1 1 2 2 2 0 Nucleoporin homology of Germinal-centre associated nuclear protein Gln-synt_C PF00120.24 CRG87563.1 - 3.3e-17 62.5 0.0 1.5e-14 53.7 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 CRG87563.1 - 4.8e-13 48.7 0.0 8e-13 47.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Sugar_tr PF00083.24 CRG87564.1 - 1.3e-113 380.3 21.6 1.6e-113 380.0 21.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG87564.1 - 5.7e-18 65.0 31.1 1.9e-17 63.3 24.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG87564.1 - 2.5e-07 29.4 1.5 5.9e-07 28.1 1.5 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family zf-CCHC PF00098.23 CRG87565.1 - 8.2e-52 171.1 101.6 4e-07 29.8 2.9 11.3 11 0 0 11 11 11 11 Zinc knuckle 3HCDH_N PF02737.18 CRG87565.1 - 2.1e-28 99.4 0.0 4.1e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain zf-CCHC_4 PF14392.6 CRG87565.1 - 5e-11 42.1 58.9 0.0097 15.6 0.0 11.2 11 0 0 11 11 11 7 Zinc knuckle zf-CCHC_2 PF13696.6 CRG87565.1 - 1.5e-10 40.7 82.2 0.0013 18.5 0.4 10.9 11 0 0 11 11 11 7 Zinc knuckle 3HCDH PF00725.22 CRG87565.1 - 2e-10 41.1 0.0 4.3e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain zf-CCHC_3 PF13917.6 CRG87565.1 - 6.3e-07 29.3 71.2 0.03 14.3 0.5 11.2 2 2 9 11 11 11 5 Zinc knuckle zf-CCHC_6 PF15288.6 CRG87565.1 - 1.7e-05 24.5 1.9 1.7e-05 24.5 1.9 10.9 9 2 2 11 11 11 5 Zinc knuckle DAO PF01266.24 CRG87565.1 - 0.015 14.9 0.0 0.52 9.8 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG87565.1 - 0.14 12.4 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Fungal_trans PF04082.18 CRG87566.1 - 1.3e-28 99.8 0.8 1.3e-28 99.8 0.8 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 CRG87566.1 - 0.06 12.1 1.8 0.25 10.1 1.2 2.1 1 1 0 1 1 1 0 Fungal specific transcription factor domain Ribonuc_L-PSP PF01042.21 CRG87567.1 - 7.3e-17 61.5 0.0 1.1e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP NOGCT PF08155.11 CRG87567.1 - 0.082 12.9 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 NOGCT (NUC087) domain Abhydrolase_1 PF00561.20 CRG87568.1 - 2.8e-13 50.1 1.9 7.9e-13 48.6 0.2 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG87568.1 - 0.0019 17.5 0.0 0.004 16.5 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CRG87568.1 - 0.091 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Amidase PF01425.21 CRG87569.1 - 1.2e-72 245.3 0.5 2.5e-72 244.3 0.5 1.5 1 1 0 1 1 1 1 Amidase p450 PF00067.22 CRG87570.1 - 2e-56 191.7 0.0 2.8e-56 191.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 adh_short_C2 PF13561.6 CRG87570.1 - 5.8e-31 107.8 0.1 1.9e-30 106.2 0.1 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87570.1 - 1.5e-24 86.5 0.0 5.9e-24 84.6 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG87570.1 - 0.034 14.1 0.2 1.4 8.7 0.0 2.3 2 0 0 2 2 2 0 KR domain Aldolase_II PF00596.21 CRG87571.1 - 5.9e-50 169.8 0.8 7.9e-50 169.4 0.8 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain AA_permease PF00324.21 CRG87572.1 - 2.4e-99 333.1 37.1 2.9e-99 332.9 37.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG87572.1 - 5.9e-19 68.2 40.1 9.6e-19 67.5 40.1 1.3 1 0 0 1 1 1 1 Amino acid permease p450 PF00067.22 CRG87573.1 - 7.6e-55 186.5 0.0 3e-54 184.5 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 2-Hacid_dh_C PF02826.19 CRG87574.1 - 2.7e-41 140.9 0.0 4.2e-30 104.4 0.0 2.3 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 CRG87574.1 - 0.016 15.4 0.0 0.033 14.4 0.0 1.5 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 CRG87574.1 - 0.018 15.5 0.0 0.038 14.5 0.0 1.5 1 1 0 1 1 1 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 CRG87574.1 - 0.036 13.3 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CRG87574.1 - 0.09 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2OG-FeII_Oxy_3 PF13640.6 CRG87575.1 - 3.6e-05 24.6 0.0 5.9e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-Fe_Oxy_2 PF10014.9 CRG87575.1 - 0.031 14.1 0.0 0.055 13.3 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe dioxygenase AA_permease PF00324.21 CRG87576.1 - 2e-91 307.0 38.3 2.8e-68 230.7 22.3 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 CRG87576.1 - 3.7e-11 42.5 34.1 5.4e-09 35.4 34.1 2.1 1 1 0 1 1 1 1 Amino acid permease Actin PF00022.19 CRG87577.1 - 8.5e-128 426.4 0.0 4.9e-127 423.9 0.0 1.8 1 1 0 1 1 1 1 Actin DUF4332 PF14229.6 CRG87577.1 - 0.083 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Glyco_tran_28_C PF04101.16 CRG87578.1 - 1.8e-17 63.8 0.0 1.8e-16 60.5 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 CRG87578.1 - 0.0061 15.4 0.0 0.0087 14.9 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase MRP-S28 PF10213.9 CRG87579.1 - 1.8e-45 154.5 0.2 3.3e-45 153.6 0.2 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein zf-PHD-like PF15446.6 CRG87580.1 - 9.6e-66 220.6 6.2 9.6e-66 220.6 6.2 1.9 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 CRG87580.1 - 3.4e-53 180.6 0.1 5.4e-53 179.9 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CCCH_6 PF18585.1 CRG87580.1 - 1.3e-25 89.0 0.7 3.7e-25 87.6 0.7 1.9 1 0 0 1 1 1 1 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 Helicase_C PF00271.31 CRG87580.1 - 2.3e-19 69.8 0.0 7.4e-19 68.1 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 CRG87580.1 - 1.1e-10 41.2 4.3 2.2e-10 40.2 4.3 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PHD PF00628.29 CRG87580.1 - 9e-08 31.9 12.0 8.6e-07 28.8 3.9 3.3 2 1 0 2 2 2 2 PHD-finger Chromo PF00385.24 CRG87580.1 - 9.5e-05 22.2 8.7 0.031 14.2 0.8 3.2 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 CRG87580.1 - 0.0011 19.0 0.0 0.0047 16.9 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Prok-RING_1 PF14446.6 CRG87580.1 - 0.0028 17.5 2.7 0.0098 15.8 2.7 1.9 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 DUF1087 PF06465.13 CRG87580.1 - 0.0035 17.3 0.0 0.014 15.4 0.0 2.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) SnAC PF14619.6 CRG87580.1 - 0.02 15.5 4.1 0.099 13.3 0.3 3.3 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex Zf_RING PF16744.5 CRG87580.1 - 7.9 6.7 9.4 0.2 11.8 1.3 2.5 2 1 0 2 2 2 0 KIAA1045 RING finger SpoU_methylase PF00588.19 CRG87581.1 - 2.7e-22 79.5 0.0 1.7e-21 76.9 0.0 2.1 1 1 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 CRG87581.1 - 9.3e-08 32.2 0.0 2.1e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding HIP1_clath_bdg PF16515.5 CRG87581.1 - 0.2 12.3 8.4 0.59 10.8 8.4 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2570 PF10828.8 CRG87581.1 - 0.5 10.2 2.2 1.1 9.1 2.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) VSG_B PF13206.6 CRG87581.1 - 0.52 9.5 3.3 0.77 9.0 3.3 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain Asp PF00026.23 CRG87582.1 - 1.9e-67 228.0 7.1 2.1e-67 227.8 7.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG87582.1 - 2.6e-10 40.8 5.2 2.1e-05 24.8 0.1 2.8 1 1 2 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG87582.1 - 0.00095 19.8 1.1 0.78 10.4 0.1 2.8 3 0 0 3 3 3 2 Aspartyl protease SNF2_N PF00176.23 CRG87583.1 - 3.8e-75 252.8 0.1 6.8e-75 252.0 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 CRG87583.1 - 2.3e-40 137.2 2.4 1.4e-39 134.7 2.4 2.5 1 0 0 1 1 1 1 SLIDE HAND PF09110.11 CRG87583.1 - 8.7e-38 129.5 2.7 8.7e-38 129.5 2.7 3.6 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 CRG87583.1 - 5.1e-18 65.4 0.2 5.4e-17 62.1 0.0 2.7 3 0 0 3 3 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG87583.1 - 1.6e-12 47.8 0.3 9.7e-12 45.2 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CRG87583.1 - 2e-05 23.9 0.0 6.2e-05 22.3 0.0 1.8 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 CRG87583.1 - 0.00019 21.2 0.0 0.00064 19.5 0.0 1.9 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DEAD PF00270.29 CRG87583.1 - 0.001 18.8 0.0 0.0033 17.2 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 CRG87583.1 - 0.04 13.1 0.3 0.096 11.9 0.3 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AAA_14 PF13173.6 CRG87583.1 - 0.046 13.8 0.0 0.21 11.6 0.0 2.2 1 0 0 1 1 1 0 AAA domain DEAD_2 PF06733.15 CRG87583.1 - 0.064 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 Tn7_Tnp_TnsA_C PF08721.11 CRG87583.1 - 0.12 13.0 0.4 0.69 10.6 0.1 2.6 2 0 0 2 2 1 0 TnsA endonuclease C terminal DUF4588 PF15251.6 CRG87584.1 - 4.1e-09 36.6 0.2 7.3e-09 35.8 0.2 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) TFIIF_alpha PF05793.12 CRG87584.1 - 0.18 10.4 4.1 0.24 9.9 4.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Adap_comp_sub PF00928.21 CRG87585.1 - 1e-63 215.2 0.0 1.5e-63 214.6 0.0 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CRG87585.1 - 0.029 14.3 0.1 0.048 13.6 0.1 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Aldedh PF00171.22 CRG87586.1 - 3.1e-75 253.5 0.0 4.2e-75 253.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ICL PF00463.21 CRG87587.1 - 1.7e-293 973.9 3.9 1.9e-293 973.8 3.9 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 CRG87587.1 - 6.7e-12 45.4 0.1 2.8e-11 43.3 0.0 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF3197 PF11432.8 CRG87587.1 - 0.19 11.6 0.9 15 5.5 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF3197) Trehalase PF01204.18 CRG87588.1 - 2.6e-186 620.4 0.0 3.3e-186 620.1 0.0 1.1 1 0 0 1 1 1 1 Trehalase adh_short_C2 PF13561.6 CRG87588.1 - 1.3e-48 165.6 0.0 1.9e-48 165.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87588.1 - 9.5e-45 152.5 0.0 2e-44 151.4 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase Trehalase_Ca-bi PF07492.11 CRG87588.1 - 1.5e-12 47.0 0.3 2.4e-12 46.3 0.3 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain KR PF08659.10 CRG87588.1 - 2.5e-06 27.5 0.0 4.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 KR domain OTU PF02338.19 CRG87589.1 - 2.1e-19 70.3 2.6 2.3e-18 66.9 0.6 2.5 2 1 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 CRG87589.1 - 2.1e-06 27.4 0.3 0.00028 20.4 0.0 2.7 3 0 0 3 3 3 2 Peptidase C65 Otubain HU-CCDC81_bac_2 PF18175.1 CRG87589.1 - 0.056 13.3 0.7 0.15 12.0 0.7 1.7 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 F-protein PF00469.20 CRG87589.1 - 3 7.4 8.6 2.4 7.7 5.3 2.0 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef DUF4407 PF14362.6 CRG87589.1 - 7.6 5.8 13.2 14 5.0 13.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPMT PF05724.11 CRG87590.1 - 1.8e-28 99.7 0.0 2.5e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 CRG87590.1 - 4.7e-08 33.0 0.2 1.9e-07 31.0 0.2 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87590.1 - 5.2e-08 33.4 0.0 8.9e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87590.1 - 1.9e-07 31.7 0.0 3.3e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG87590.1 - 1.7e-05 24.7 0.0 2.4e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87590.1 - 0.00048 20.8 0.0 0.00098 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 CRG87590.1 - 0.022 14.2 0.3 0.037 13.4 0.0 1.4 2 0 0 2 2 2 0 Tellurite resistance protein TehB AdoMet_MTase PF07757.13 CRG87590.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase DEC1 PF15859.5 CRG87590.1 - 0.17 12.0 0.0 7.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Deleted in esophageal cancer 1 family MFS_1 PF07690.16 CRG87591.1 - 3.9e-42 144.5 33.4 3.9e-42 144.5 33.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 CRG87591.1 - 0.00031 20.2 5.8 0.00031 20.2 5.8 2.9 2 1 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CRG87591.1 - 0.0071 14.7 9.3 0.1 10.9 1.9 2.7 2 1 0 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family PTR2 PF00854.21 CRG87591.1 - 0.14 11.0 7.2 1.5 7.5 0.3 2.7 3 0 0 3 3 3 0 POT family G_glu_transpept PF01019.21 CRG87593.1 - 7.6e-143 477.0 0.1 8.6e-143 476.8 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase FYVE PF01363.21 CRG87594.1 - 0.0026 17.9 5.3 0.0026 17.9 5.3 2.9 3 0 0 3 3 3 1 FYVE zinc finger zf-piccolo PF05715.13 CRG87594.1 - 0.0096 16.1 8.2 0.078 13.1 2.9 2.5 2 0 0 2 2 2 2 Piccolo Zn-finger FYVE_2 PF02318.16 CRG87594.1 - 0.56 10.4 7.2 0.4 10.9 1.8 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger Caleosin PF05042.13 CRG87595.1 - 2.1e-76 255.6 0.4 2.8e-76 255.2 0.4 1.2 1 0 0 1 1 1 1 Caleosin related protein EF-hand_1 PF00036.32 CRG87595.1 - 4.4e-05 22.7 0.3 0.00031 20.1 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 CRG87595.1 - 0.00017 21.3 0.9 0.0044 16.8 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 CRG87595.1 - 0.013 16.0 0.1 0.064 13.7 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.6 CRG87595.1 - 0.088 12.7 0.1 0.41 10.5 0.0 2.0 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 CRG87595.1 - 0.1 12.1 2.1 0.18 11.4 0.2 2.2 2 0 0 2 2 2 0 EF hand FAD_binding_3 PF01494.19 CRG87596.1 - 7.7e-58 196.4 0.1 4.3e-52 177.5 0.0 4.1 2 1 0 2 2 2 2 FAD binding domain adh_short_C2 PF13561.6 CRG87596.1 - 2.5e-34 118.9 1.0 1.1e-33 116.8 1.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87596.1 - 1.2e-33 116.2 0.3 3e-33 114.9 0.3 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87596.1 - 4.4e-07 30.0 0.3 4.4e-07 30.0 0.3 1.6 2 0 0 2 2 2 1 KR domain HI0933_like PF03486.14 CRG87596.1 - 5.2e-06 25.4 1.6 0.0001 21.2 0.0 2.4 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 CRG87596.1 - 6.1e-05 23.5 0.6 0.28 11.8 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 CRG87596.1 - 0.00026 21.0 0.1 0.00056 19.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_8 PF13450.6 CRG87596.1 - 0.00028 21.0 1.0 0.00067 19.8 0.0 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG87596.1 - 0.00029 20.2 0.7 0.058 12.6 0.0 3.4 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG87596.1 - 0.00068 19.0 0.4 0.0062 15.8 0.0 2.2 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 CRG87596.1 - 0.00082 18.8 6.1 0.0022 17.4 0.0 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG87596.1 - 0.00098 18.5 0.4 0.18 11.1 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 CRG87596.1 - 0.0012 18.1 1.8 0.019 14.0 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Glu_dehyd_C PF16912.5 CRG87596.1 - 0.0016 18.0 0.4 0.15 11.5 0.2 2.3 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus Pyr_redox_3 PF13738.6 CRG87596.1 - 0.0028 17.0 0.5 0.058 12.6 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG87596.1 - 0.0097 15.5 0.0 0.024 14.2 0.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 CRG87596.1 - 0.089 12.9 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.12 CRG87596.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Dala_Dala_lig_C PF07478.13 CRG87597.1 - 5.1e-15 55.6 0.0 1.9e-14 53.7 0.0 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CRG87597.1 - 0.0068 16.5 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 CRG87597.1 - 0.017 14.9 0.0 0.046 13.5 0.0 1.7 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain KGG PF10685.9 CRG87598.1 - 1e-19 70.1 15.3 8.4e-09 35.4 0.3 3.1 3 0 0 3 3 3 3 Stress-induced bacterial acidophilic repeat motif CHZ PF09649.10 CRG87599.1 - 0.00086 18.7 0.2 0.0022 17.4 0.2 1.7 1 0 0 1 1 1 1 Histone chaperone domain CHZ Fungal_trans PF04082.18 CRG87600.1 - 3.8e-24 85.1 1.7 7e-24 84.3 1.7 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG87600.1 - 2.3e-05 24.6 10.6 0.0056 17.1 1.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG87600.1 - 0.0069 17.1 8.3 0.08 13.8 0.7 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 CRG87600.1 - 0.22 12.2 1.8 9.7 6.9 0.3 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain tRNA-synt_2b PF00587.25 CRG87601.1 - 1.1e-30 106.9 0.0 6.5e-28 97.9 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CRG87601.1 - 2.5e-16 59.6 0.1 7.3e-16 58.1 0.1 1.9 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 CRG87601.1 - 3.3e-14 52.7 0.0 6.4e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 CRG87601.1 - 0.00094 19.2 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 TGS domain Gar1 PF04410.14 CRG87602.1 - 3.3e-38 130.9 0.0 4.4e-38 130.5 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region FAD_binding_4 PF01565.23 CRG87603.1 - 2.2e-22 79.3 0.2 4.6e-22 78.2 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain CDP-OH_P_transf PF01066.21 CRG87603.1 - 1e-12 48.6 0.3 3.7e-12 46.8 0.1 2.1 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase BBE PF08031.12 CRG87603.1 - 2.4e-11 43.5 0.2 5e-11 42.5 0.2 1.6 1 0 0 1 1 1 1 Berberine and berberine like Cation_efflux PF01545.21 CRG87603.1 - 0.031 14.0 1.4 6.6 6.4 0.0 2.4 2 0 0 2 2 2 0 Cation efflux family adh_short PF00106.25 CRG87604.1 - 5e-29 101.2 0.3 1e-28 100.2 0.3 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87604.1 - 4.6e-17 62.4 0.1 7.1e-17 61.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG87604.1 - 1.4e-09 38.1 0.1 2e-09 37.6 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CRG87604.1 - 7.2e-05 22.3 0.1 9.3e-05 22.0 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CRG87604.1 - 0.00039 19.9 0.0 0.00051 19.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CRG87604.1 - 0.012 15.9 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 CRG87604.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 ThiF family WSC PF01822.19 CRG87605.1 - 1.1e-11 44.8 7.3 2.2e-11 43.8 7.3 1.6 1 0 0 1 1 1 1 WSC domain SKG6 PF08693.10 CRG87605.1 - 3.2e-07 29.7 3.0 3.2e-07 29.7 3.0 2.0 2 0 0 2 2 2 1 Transmembrane alpha-helix domain Trp_oprn_chp PF09534.10 CRG87605.1 - 0.0051 16.6 0.2 0.0087 15.9 0.2 1.3 1 0 0 1 1 1 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Amnionless PF14828.6 CRG87605.1 - 0.0071 15.2 0.0 0.0093 14.8 0.0 1.1 1 0 0 1 1 1 1 Amnionless Gram_pos_anchor PF00746.21 CRG87605.1 - 0.034 14.1 1.9 0.12 12.4 1.9 1.9 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF4448 PF14610.6 CRG87605.1 - 0.05 13.4 0.0 0.076 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Insulin_TMD PF17870.1 CRG87605.1 - 0.14 12.3 0.2 0.3 11.2 0.2 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FRQ PF09421.10 CRG87606.1 - 5.1e-28 97.7 10.4 6.5e-20 70.8 0.1 3.5 1 1 1 2 2 2 2 Frequency clock protein CoA_trans PF01144.23 CRG87607.1 - 5.8e-104 346.2 2.4 1.1e-63 214.6 0.5 2.0 2 0 0 2 2 2 2 Coenzyme A transferase DUF2370 PF10176.9 CRG87609.1 - 4.4e-93 311.1 0.0 1.1e-92 309.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Pkinase PF00069.25 CRG87609.1 - 1.3e-65 221.4 0.0 2.1e-65 220.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87609.1 - 1.3e-30 106.6 0.0 2.9e-30 105.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG87609.1 - 0.029 13.3 0.0 0.052 12.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RPT PF13446.6 CRG87610.1 - 1.9e-55 184.6 0.1 1.6e-19 69.6 0.0 4.5 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH PF00443.29 CRG87610.1 - 1.2e-43 149.5 0.0 2.9e-43 148.2 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG87610.1 - 0.0027 17.3 8.0 0.026 14.1 8.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Microvir_H PF04687.12 CRG87610.1 - 0.083 12.3 0.2 0.17 11.3 0.2 1.4 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Tim17 PF02466.19 CRG87611.1 - 3.8e-07 30.5 9.3 8.9e-07 29.3 8.8 1.9 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family PH PF00169.29 CRG87612.1 - 7.2e-05 23.2 0.3 0.00027 21.4 0.0 2.2 3 0 0 3 3 3 1 PH domain DUF5344 PF17279.2 CRG87612.1 - 0.0052 17.3 1.7 0.41 11.2 0.2 3.1 3 0 0 3 3 3 1 Family of unknown function (DUF5344) DUF3921 PF13060.6 CRG87612.1 - 0.12 12.5 0.3 0.44 10.6 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) Prominin PF05478.11 CRG87612.1 - 0.33 8.8 0.1 0.48 8.3 0.1 1.1 1 0 0 1 1 1 0 Prominin RRM_1 PF00076.22 CRG87613.1 - 1.3e-51 172.3 0.0 7e-16 57.8 0.0 3.9 3 1 1 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG87613.1 - 5.8e-05 22.7 0.0 0.04 13.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CRG87613.1 - 0.00057 19.9 0.3 2.9 8.0 0.0 4.1 3 2 0 3 3 3 1 Limkain b1 RRM_3 PF08777.11 CRG87613.1 - 0.0007 19.6 0.0 0.87 9.7 0.0 3.3 3 0 0 3 3 3 1 RNA binding motif RRM_Rrp7 PF17799.1 CRG87613.1 - 0.022 14.6 0.0 3 7.6 0.0 2.9 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain ATP-grasp_2 PF08442.10 CRG87613.1 - 0.024 14.2 0.0 4.6 6.8 0.0 2.8 3 0 0 3 3 3 0 ATP-grasp domain DUF3343 PF11823.8 CRG87613.1 - 0.057 12.9 0.0 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) RRM_occluded PF16842.5 CRG87613.1 - 0.17 11.7 0.0 15 5.5 0.0 3.3 3 1 0 3 3 3 0 Occluded RNA-recognition motif COQ9 PF08511.11 CRG87614.1 - 2e-26 91.5 0.0 3.7e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 COQ9 WD40 PF00400.32 CRG87615.1 - 3.8e-08 33.9 0.3 3.6 8.6 0.0 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat RasGAP PF00616.19 CRG87616.1 - 9.1e-30 103.9 0.0 1e-20 74.3 0.0 2.7 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 CRG87616.1 - 1.6e-09 38.0 0.5 8.7e-08 32.4 0.1 3.1 2 1 0 2 2 2 1 C2 domain Glyco_hydro_76 PF03663.14 CRG87617.1 - 2.1e-33 116.3 13.0 3.1e-33 115.8 13.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_9 PF00759.19 CRG87617.1 - 1.3e-06 28.1 5.1 2.8e-05 23.8 0.2 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 9 Glyco_hydro_88 PF07470.13 CRG87617.1 - 1.3e-05 24.5 1.9 0.0037 16.4 0.0 2.8 3 1 0 3 3 3 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 CRG87617.1 - 0.00094 18.7 1.4 0.19 11.2 0.0 3.2 3 1 0 3 3 3 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 CRG87617.1 - 0.0056 15.2 0.3 0.081 11.4 0.1 2.1 1 1 1 2 2 2 1 Beta-L-arabinofuranosidase, GH127 APG9 PF04109.16 CRG87618.1 - 6.8e-214 711.3 13.4 7.9e-214 711.1 13.4 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 Glyco_hydro_47 PF01532.20 CRG87619.1 - 8.1e-190 631.6 0.0 9.7e-190 631.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF2013 PF09431.10 CRG87620.1 - 8.6e-31 106.9 2.9 1.5e-30 106.1 2.5 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2013) DRIM PF07539.12 CRG87620.1 - 0.022 13.1 0.1 0.034 12.4 0.1 1.3 1 0 0 1 1 1 0 Down-regulated in metastasis DUF1236 PF06823.12 CRG87620.1 - 0.066 13.1 0.8 1.3 8.9 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1236) Aminotran_1_2 PF00155.21 CRG87621.1 - 3e-35 122.1 0.0 5.6e-35 121.2 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II Glyco_hydro_17 PF00332.18 CRG87621.1 - 5.6e-05 22.9 0.3 0.00013 21.7 0.1 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 Cys_Met_Meta_PP PF01053.20 CRG87621.1 - 0.015 13.8 0.0 0.075 11.5 0.0 2.1 3 0 0 3 3 3 0 Cys/Met metabolism PLP-dependent enzyme Glucan_synthase PF02364.15 CRG87622.1 - 0 1386.4 0.0 0 1386.0 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 CRG87622.1 - 3e-44 150.5 0.1 8.1e-44 149.1 0.1 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 SprT-like PF10263.9 CRG87623.1 - 5.4e-39 132.6 0.2 1.1e-38 131.6 0.2 1.5 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 CRG87623.1 - 3.6e-10 39.6 1.7 7.6e-10 38.5 1.7 1.6 1 0 0 1 1 1 1 SprT-like zinc ribbon domain DUF4379 PF14311.6 CRG87623.1 - 0.042 14.2 1.8 0.14 12.6 1.8 1.9 1 0 0 1 1 1 0 Probable Zinc-ribbon domain Zn-ribbon_8 PF09723.10 CRG87623.1 - 0.11 12.6 0.3 0.33 11.1 0.3 1.7 1 0 0 1 1 1 0 Zinc ribbon domain AIM24 PF01987.17 CRG87624.1 - 6.6e-47 159.9 0.0 8.5e-47 159.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 HHH_8 PF14716.6 CRG87624.1 - 0.071 13.5 0.1 0.16 12.4 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain ABC_membrane PF00664.23 CRG87625.1 - 7.6e-38 130.7 8.8 1e-37 130.3 8.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 CRG87625.1 - 8.3e-34 117.0 0.0 1.6e-33 116.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CRG87625.1 - 4.7e-06 26.2 0.0 0.0014 18.2 0.0 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG87625.1 - 0.00058 20.1 0.0 0.0019 18.5 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG87625.1 - 0.0008 19.8 0.0 0.0018 18.6 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 CRG87625.1 - 0.0027 17.6 0.0 0.024 14.5 0.0 2.2 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_14 PF13173.6 CRG87625.1 - 0.016 15.3 0.1 0.63 10.1 0.0 2.6 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 CRG87625.1 - 0.044 14.2 0.0 0.29 11.6 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CRG87625.1 - 0.044 13.5 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 CRG87625.1 - 0.067 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 CRG87625.1 - 0.079 12.7 0.0 0.21 11.3 0.0 1.7 1 0 0 1 1 1 0 Cytidylate kinase AAA_24 PF13479.6 CRG87625.1 - 0.088 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CRG87625.1 - 0.09 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.7 CRG87625.1 - 0.15 10.9 0.1 1.3 7.9 0.0 2.1 2 1 1 3 3 3 0 AAA-like domain AAA_23 PF13476.6 CRG87625.1 - 0.2 12.2 0.0 0.45 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-C3H1 PF10650.9 CRG87627.1 - 3e-13 49.2 0.9 5.3e-13 48.4 0.9 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain DUF3450 PF11932.8 CRG87627.1 - 0.63 9.3 12.5 0.025 13.9 5.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Myosin_head PF00063.21 CRG87628.1 - 1.1e-269 896.3 0.2 1.1e-269 896.3 0.2 2.2 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 CRG87628.1 - 1.9e-20 72.4 278.3 1.9e-09 36.0 44.3 6.4 1 1 4 5 5 5 5 Myosin tail Myosin_N PF02736.19 CRG87628.1 - 3.3e-12 46.0 0.1 8.9e-12 44.7 0.1 1.8 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain GAS PF13851.6 CRG87628.1 - 0.0014 18.0 20.0 0.0014 18.0 20.0 14.3 2 2 8 13 13 13 2 Growth-arrest specific micro-tubule binding AAA_22 PF13401.6 CRG87628.1 - 0.11 12.8 0.0 0.11 12.8 0.0 5.5 4 1 1 5 5 5 0 AAA domain Isy1 PF06246.12 CRG87629.1 - 2.7e-89 299.1 1.2 3.1e-89 298.9 1.2 1.0 1 0 0 1 1 1 1 Isy1-like splicing family MMR_HSR1 PF01926.23 CRG87630.1 - 2.6e-13 50.1 0.0 9.1e-13 48.3 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG87630.1 - 3.1e-06 27.2 0.0 6.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 CRG87630.1 - 0.00024 20.7 0.0 0.00039 20.0 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Septin PF00735.18 CRG87630.1 - 0.0014 18.0 0.0 0.0028 17.0 0.0 1.4 1 0 0 1 1 1 1 Septin AAA_16 PF13191.6 CRG87630.1 - 0.0039 17.6 0.0 0.0084 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 CRG87630.1 - 0.0044 16.4 0.0 0.011 15.1 0.0 1.7 1 0 0 1 1 1 1 AIG1 family MeaB PF03308.16 CRG87630.1 - 0.013 14.5 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CRG87630.1 - 0.12 12.9 0.0 0.12 12.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CRG87630.1 - 0.33 11.0 3.1 0.68 10.0 0.1 2.6 2 1 1 3 3 3 0 Dynamin family HCO3_cotransp PF00955.21 CRG87631.1 - 1.5e-71 241.8 10.7 2.2e-40 139.0 0.3 2.1 1 1 1 2 2 2 2 HCO3- transporter family DASH_Dam1 PF08653.10 CRG87631.1 - 0.13 12.1 0.2 0.32 10.8 0.2 1.6 1 0 0 1 1 1 0 DASH complex subunit Dam1 DUF3341 PF11821.8 CRG87631.1 - 0.2 11.3 2.5 0.19 11.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) PI3Ka PF00613.20 CRG87632.1 - 9.2e-58 194.7 0.1 1.6e-57 193.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 CRG87632.1 - 1.5e-45 156.0 0.0 9.7e-32 110.7 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 CRG87632.1 - 1.8e-30 105.7 0.0 3.2e-30 104.9 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 Nse4_C PF08743.10 CRG87633.1 - 3.1e-30 104.3 0.0 9e-30 102.8 0.0 1.9 1 0 0 1 1 1 1 Nse4 C-terminal DUF4336 PF14234.6 CRG87633.1 - 5.2e-18 65.3 0.1 1.7e-12 47.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4336) Nse4-Nse3_bdg PF15412.6 CRG87633.1 - 1.4e-15 57.2 0.2 3e-15 56.1 0.2 1.6 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Syntaxin-18_N PF10496.9 CRG87633.1 - 0.12 12.6 1.9 0.54 10.5 1.9 2.2 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus Ribosomal_S20p PF01649.18 CRG87633.1 - 8.4 7.1 12.5 3.8 8.2 2.4 3.1 2 2 0 2 2 2 0 Ribosomal protein S20 Metallophos PF00149.28 CRG87634.1 - 1.5e-13 51.7 0.1 2.2e-13 51.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG87634.1 - 1.5e-05 25.3 0.1 2.5e-05 24.5 0.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Colicin_E5 PF12106.8 CRG87634.1 - 0.12 12.6 0.1 0.24 11.7 0.1 1.5 1 0 0 1 1 1 0 Colicin E5 ribonuclease domain ThiF PF00899.21 CRG87635.1 - 5.8e-42 143.7 0.0 9.3e-42 143.1 0.0 1.2 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 CRG87635.1 - 0.0045 17.2 0.1 0.013 15.7 0.1 1.9 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CRG87635.1 - 0.015 15.6 1.5 0.29 11.4 1.5 2.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CRG87635.1 - 0.057 13.9 0.0 0.13 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Fusion_gly PF00523.18 CRG87635.1 - 0.077 11.2 0.0 0.11 10.7 0.0 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 Abhydrolase_1 PF00561.20 CRG87636.1 - 2.2e-47 161.9 0.0 6e-47 160.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 CRG87636.1 - 9.7e-05 22.1 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Gly_transf_sug PF04488.15 CRG87637.1 - 2e-13 50.8 0.0 4.1e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Pkinase PF00069.25 CRG87638.1 - 4.1e-64 216.5 0.0 5.2e-64 216.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87638.1 - 4.1e-34 118.0 0.0 5.5e-34 117.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ATP-synt_C PF00137.21 CRG87638.1 - 4.1e-27 94.3 36.4 1.7e-16 60.3 13.2 2.4 2 0 0 2 2 2 2 ATP synthase subunit C Haspin_kinase PF12330.8 CRG87638.1 - 5.1e-05 22.4 0.0 7.2e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CRG87638.1 - 0.0068 15.8 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CRG87638.1 - 0.047 13.6 0.0 0.16 11.9 0.0 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family Phage_int_SAM_1 PF02899.17 CRG87638.1 - 0.17 12.2 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain CNH PF00780.22 CRG87639.1 - 5.1e-80 269.0 0.0 3.2e-78 263.1 0.0 2.2 2 0 0 2 2 2 2 CNH domain PH_5 PF15405.6 CRG87639.1 - 2.1e-43 147.6 0.1 5.6e-43 146.3 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 CRG87639.1 - 3.4e-38 131.7 0.0 6.6e-38 130.8 0.0 1.5 1 0 0 1 1 1 1 RhoGEF domain DEP PF00610.21 CRG87639.1 - 5.5e-15 55.2 0.0 1.2e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Septin PF00735.18 CRG87640.1 - 3.4e-109 364.5 0.2 5.5e-109 363.8 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CRG87640.1 - 9.1e-05 22.5 0.0 0.00022 21.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG87640.1 - 0.00046 19.8 0.2 0.033 13.7 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 CRG87640.1 - 0.0038 17.2 2.9 0.009 15.9 0.2 2.7 3 1 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 CRG87640.1 - 0.014 15.7 1.7 0.039 14.2 0.0 2.4 2 1 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 CRG87640.1 - 0.015 15.4 3.9 1.6 8.7 0.0 3.2 2 1 1 3 3 3 0 Dynamin family AAA_33 PF13671.6 CRG87640.1 - 0.028 14.6 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 CRG87640.1 - 0.093 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ribosomal_S17e PF00833.18 CRG87640.1 - 0.26 11.2 4.4 0.63 10.0 4.4 1.6 1 0 0 1 1 1 0 Ribosomal S17 EB1 PF03271.17 CRG87640.1 - 0.31 11.3 3.3 3.5 8.0 1.3 2.7 2 0 0 2 2 2 0 EB1-like C-terminal motif WD40 PF00400.32 CRG87641.1 - 1.6e-05 25.6 0.1 0.14 13.1 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87641.1 - 0.0002 21.6 0.0 0.18 12.1 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG87641.1 - 0.012 14.6 0.1 0.078 11.9 0.0 2.1 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 CRG87641.1 - 0.016 13.3 0.0 0.02 12.9 0.0 1.1 1 0 0 1 1 1 0 IKI3 family Nbas_N PF15492.6 CRG87641.1 - 0.041 13.2 0.0 0.24 10.7 0.0 2.0 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 CRG87641.1 - 0.18 10.1 0.0 0.29 9.4 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz RRM_1 PF00076.22 CRG87642.1 - 1.1e-19 70.0 0.6 1e-18 66.9 0.0 2.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG87642.1 - 4e-05 23.6 0.0 0.00013 22.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif Rgp1 PF08737.10 CRG87642.1 - 1.3 8.1 5.1 2.9 7.0 5.1 1.6 1 1 0 1 1 1 0 Rgp1 SelP_N PF04592.14 CRG87642.1 - 8.8 5.7 12.5 15 4.9 12.5 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DLIC PF05783.11 CRG87643.1 - 2.5e-37 128.9 5.6 2.4e-34 119.0 0.0 3.6 2 2 0 2 2 2 2 Dynein light intermediate chain (DLIC) Urb2 PF10441.9 CRG87643.1 - 0.07 13.1 0.0 0.65 9.9 0.0 2.1 2 0 0 2 2 2 0 Urb2/Npa2 family Y_phosphatase3 PF13350.6 CRG87644.1 - 3.5e-61 207.2 0.0 3.9e-61 207.0 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 CRG87644.1 - 4.6e-05 23.1 0.0 5.7e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 CRG87644.1 - 0.0019 17.8 0.0 0.0031 17.1 0.0 1.6 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 CRG87644.1 - 0.027 14.3 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Myotub-related PF06602.14 CRG87644.1 - 0.041 12.8 0.0 0.046 12.6 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Spermine_synth PF01564.17 CRG87645.1 - 4.2e-07 29.6 0.0 7e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_12 PF08242.12 CRG87645.1 - 0.0091 16.7 0.0 0.019 15.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG87645.1 - 0.023 14.5 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF1772 PF08592.11 CRG87645.1 - 1.5 9.1 12.3 7.1 6.9 0.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1772) DUF2052 PF09747.9 CRG87646.1 - 7.4e-23 81.7 19.5 1.1e-11 45.3 1.2 2.1 1 1 1 2 2 2 2 Coiled-coil domain containing protein (DUF2052) Pkinase PF00069.25 CRG87647.1 - 2.2e-50 171.5 0.0 3.5e-50 170.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87647.1 - 5e-25 88.3 0.0 8.3e-24 84.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG87647.1 - 0.00082 18.8 0.2 0.0016 17.8 0.0 1.5 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CRG87647.1 - 0.056 13.0 0.1 0.33 10.5 0.0 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CRG87647.1 - 0.14 10.9 0.5 0.22 10.2 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 CRG87647.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AMP-binding PF00501.28 CRG87648.1 - 5.2e-97 325.1 0.0 6.1e-97 324.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG87648.1 - 4.1e-14 53.3 0.3 1.2e-13 51.9 0.3 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain UBA_4 PF14555.6 CRG87649.1 - 1.4e-06 28.0 0.4 0.0047 16.7 0.1 2.6 2 0 0 2 2 2 2 UBA-like domain Topoisom_bac PF01131.20 CRG87649.1 - 0.015 14.3 1.1 0.029 13.4 0.0 1.9 3 0 0 3 3 3 0 DNA topoisomerase DASH_Dad2 PF08654.10 CRG87649.1 - 0.11 13.0 0.5 0.42 11.0 0.0 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad2 Sad1_UNC PF07738.13 CRG87649.1 - 0.13 12.2 0.2 0.59 10.2 0.0 2.0 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal Dynactin_p22 PF07426.11 CRG87650.1 - 1.5e-09 38.0 0.0 2.4e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Dynactin subunit p22 SH3_1 PF00018.28 CRG87651.1 - 6e-11 41.8 0.1 1.1e-10 40.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG87651.1 - 9.6e-08 31.8 0.0 1.9e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CRG87651.1 - 5.1e-06 26.1 0.0 9.2e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 CRG87651.1 - 0.002 18.2 0.0 0.0035 17.4 0.0 1.3 1 0 0 1 1 1 1 SH3 domain TMEM220 PF15071.6 CRG87651.1 - 0.15 12.9 2.1 0.32 11.8 2.0 1.6 1 1 0 1 1 1 0 Transmembrane family 220, helix 7tm_6 PF02949.20 CRG87651.1 - 9.8 5.2 9.4 0.69 8.9 0.4 2.1 1 1 1 2 2 2 0 7tm Odorant receptor PQ-loop PF04193.14 CRG87652.1 - 5.2e-22 77.4 11.2 2.8e-19 68.6 1.3 3.2 2 1 1 3 3 3 2 PQ loop repeat ABC2_membrane_5 PF13346.6 CRG87652.1 - 0.63 9.6 14.5 0.22 11.1 8.4 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein GST_N_2 PF13409.6 CRG87653.1 - 7.4e-08 32.6 0.0 1.5e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG87653.1 - 9.1e-07 28.8 0.1 2.3e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG87653.1 - 7.8e-06 26.2 0.0 1.8e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG87653.1 - 0.096 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain NSP2-B_epitope PF14757.6 CRG87653.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Immunogenic region of nsp2 protein of arterivirus polyprotein E1-E2_ATPase PF00122.20 CRG87654.1 - 3.6e-46 157.0 2.9 1e-45 155.5 2.9 1.9 1 0 0 1 1 1 1 E1-E2 ATPase ABC_tran PF00005.27 CRG87654.1 - 3.8e-31 108.4 0.0 1.7e-21 77.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter Hydrolase PF00702.26 CRG87654.1 - 3.5e-24 86.2 0.1 6.3e-24 85.4 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CRG87654.1 - 6.5e-06 26.5 1.7 7.7e-06 26.3 0.3 1.9 2 0 0 2 2 1 1 Heavy-metal-associated domain ABC_membrane PF00664.23 CRG87654.1 - 1.6e-05 24.7 7.0 1.6e-05 24.7 7.0 3.3 4 0 0 4 4 3 1 ABC transporter transmembrane region DUF87 PF01935.17 CRG87654.1 - 0.0033 17.6 0.1 0.007 16.5 0.1 1.5 1 0 0 1 1 1 1 Helicase HerA, central domain T2SSE PF00437.20 CRG87654.1 - 0.01 14.9 0.1 0.045 12.8 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_21 PF13304.6 CRG87654.1 - 0.022 14.6 1.9 0.81 9.4 0.1 3.0 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Hydrolase_3 PF08282.12 CRG87654.1 - 0.059 13.1 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase AAA_29 PF13555.6 CRG87654.1 - 0.063 13.0 0.1 0.18 11.5 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CRG87654.1 - 0.064 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 CRG87654.1 - 0.071 13.4 0.1 1.8 8.8 0.0 2.5 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit MeaB PF03308.16 CRG87654.1 - 0.11 11.4 0.0 0.22 10.4 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 CRG87654.1 - 0.11 12.3 0.1 0.44 10.4 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 CRG87654.1 - 0.17 12.1 0.0 0.59 10.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain Rhodanese PF00581.20 CRG87654.1 - 0.19 12.3 0.0 0.46 11.0 0.0 1.6 1 0 0 1 1 1 0 Rhodanese-like domain Sigma54_activat PF00158.26 CRG87654.1 - 0.19 11.4 0.0 0.86 9.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain MFS_1 PF07690.16 CRG87655.1 - 2.3e-32 112.3 38.5 9.7e-31 107.0 29.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG87655.1 - 5.7e-05 21.7 4.5 5.7e-05 21.7 4.5 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Response_reg PF00072.24 CRG87656.1 - 3.1e-20 72.4 0.0 1.1e-13 51.3 0.0 2.4 1 1 1 2 2 2 2 Response regulator receiver domain HLH PF00010.26 CRG87657.1 - 2e-12 46.9 0.2 4.2e-12 45.8 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF5094 PF17015.5 CRG87657.1 - 0.034 14.2 0.5 0.067 13.3 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Macoilin PF09726.9 CRG87657.1 - 0.05 12.2 10.8 0.07 11.7 10.8 1.2 1 0 0 1 1 1 0 Macoilin family Bot1p PF12298.8 CRG87658.1 - 3.5e-53 180.3 2.1 3.5e-53 180.3 2.1 1.8 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein RRM_1 PF00076.22 CRG87659.1 - 1.1e-16 60.4 0.1 8.6e-13 47.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG87659.1 - 0.13 12.1 0.0 0.38 10.6 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif Ribosomal_S16 PF00886.19 CRG87661.1 - 2.1e-26 91.7 0.0 3.4e-26 91.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S16 YjeF_N PF03853.15 CRG87662.1 - 5.4e-35 120.8 0.0 7.3e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 YjeF-related protein N-terminus PUL PF08324.11 CRG87663.1 - 5e-72 242.5 0.2 7.8e-72 241.8 0.2 1.3 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 CRG87663.1 - 8.8e-45 151.6 0.5 1.7e-44 150.7 0.5 1.5 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 CRG87663.1 - 1.8e-31 107.7 13.5 3.6e-07 30.8 0.0 7.8 8 0 0 8 8 8 5 WD domain, G-beta repeat Mcl1_mid PF12341.8 CRG87663.1 - 0.061 12.7 0.2 1.3 8.3 0.1 2.7 2 1 0 2 2 2 0 Minichromosome loss protein, Mcl1, middle region PE PF00934.20 CRG87663.1 - 0.087 13.2 0.2 5.5 7.4 0.0 3.7 4 0 0 4 4 4 0 PE family Voldacs PF03517.13 CRG87664.1 - 1.3e-27 96.6 2.1 2.9e-27 95.5 0.0 2.2 3 0 0 3 3 3 1 Regulator of volume decrease after cellular swelling Pinin_SDK_N PF04697.13 CRG87665.1 - 0.0019 18.8 0.2 0.0085 16.7 0.2 2.1 1 0 0 1 1 1 1 pinin/SDK conserved region adh_short_C2 PF13561.6 CRG87666.1 - 4.1e-51 173.8 0.6 8.4e-51 172.8 0.6 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87666.1 - 5.8e-34 117.3 1.3 3.4e-33 114.8 1.3 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87666.1 - 2.1e-07 31.0 0.9 6.6e-06 26.2 0.9 2.2 1 1 0 1 1 1 1 KR domain F420_oxidored PF03807.17 CRG87666.1 - 0.0075 16.8 0.2 0.013 16.0 0.2 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ADH_zinc_N PF00107.26 CRG87666.1 - 0.02 14.8 0.2 0.039 13.9 0.2 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GDP_Man_Dehyd PF16363.5 CRG87666.1 - 0.052 12.9 0.1 0.58 9.5 0.0 2.0 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase STALD PF18185.1 CRG87666.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Sir2- and TIR-associating SLOG family Epimerase PF01370.21 CRG87666.1 - 0.11 12.0 0.1 0.66 9.4 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family HHV-5_US34A PF17087.5 CRG87667.1 - 7.7 6.8 6.3 0.67 10.2 0.6 2.1 2 0 0 2 2 2 0 Herpesvirus US34A protein family Opi1 PF08618.10 CRG87668.1 - 5.1e-41 141.3 39.6 4.6e-32 111.8 7.1 4.6 2 2 2 4 4 4 3 Transcription factor Opi1 PriC PF07445.12 CRG87668.1 - 1 9.3 7.8 0.69 9.8 0.4 2.9 3 0 0 3 3 3 0 Primosomal replication protein priC Syntaxin-6_N PF09177.11 CRG87668.1 - 1.5 9.4 10.8 0.076 13.6 2.8 2.9 3 1 1 4 4 4 0 Syntaxin 6, N-terminal RdRP PF05183.12 CRG87669.1 - 3.9e-133 445.2 0.0 5.4e-133 444.7 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Ank_2 PF12796.7 CRG87671.1 - 3.5e-23 82.0 0.5 3.2e-06 27.6 0.0 5.5 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG87671.1 - 6.6e-19 68.0 1.1 0.011 16.3 0.0 6.1 4 1 2 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG87671.1 - 2.5e-17 61.2 1.4 0.0098 16.3 0.0 8.5 10 1 0 10 10 10 4 Ankyrin repeat Ank_5 PF13857.6 CRG87671.1 - 6.1e-17 61.5 2.1 0.0058 16.9 0.0 8.0 6 1 2 8 8 8 4 Ankyrin repeats (many copies) Ank PF00023.30 CRG87671.1 - 5.5e-15 55.1 0.2 5.8e-05 23.4 0.0 6.9 8 0 0 8 8 8 3 Ankyrin repeat F-box_4 PF15966.5 CRG87671.1 - 0.00095 19.0 0.0 0.0036 17.2 0.0 1.9 2 0 0 2 2 2 1 F-box F-box-like PF12937.7 CRG87671.1 - 0.17 11.8 0.6 0.35 10.8 0.6 1.5 1 0 0 1 1 1 0 F-box-like DUF3445 PF11927.8 CRG87672.1 - 2.8e-75 252.8 0.0 3.9e-75 252.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) PRP38 PF03371.15 CRG87673.1 - 6.9e-62 208.4 0.0 8.8e-62 208.0 0.0 1.0 1 0 0 1 1 1 1 PRP38 family Tnp_22_trimer PF17489.2 CRG87673.1 - 0.017 15.1 0.5 0.035 14.1 0.5 1.5 1 0 0 1 1 1 0 L1 transposable element trimerization domain HNH_2 PF13391.6 CRG87674.1 - 0.0011 19.0 0.0 0.0026 17.9 0.0 1.7 1 0 0 1 1 1 1 HNH endonuclease WD40 PF00400.32 CRG87676.1 - 1.2e-17 63.9 1.9 0.22 12.5 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87676.1 - 3.7e-05 23.9 0.2 5.6 7.3 0.1 4.7 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nop14 PF04147.12 CRG87676.1 - 1.6 6.8 9.5 2.5 6.2 9.5 1.2 1 0 0 1 1 1 0 Nop14-like family Pex14_N PF04695.13 CRG87676.1 - 6 7.5 12.8 6.5 7.4 1.9 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GST_C_2 PF13410.6 CRG87677.1 - 8e-08 32.2 0.7 1.7e-07 31.1 0.4 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG87677.1 - 3.8e-05 23.9 0.0 9.7e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG87677.1 - 0.00018 21.7 0.1 0.0003 20.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG87677.1 - 0.00071 19.7 0.0 0.0013 18.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG87677.1 - 0.0027 18.4 0.0 0.0058 17.3 0.0 1.5 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_N_3 PF13417.6 CRG87677.1 - 0.015 15.7 0.0 0.028 14.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Pyr_redox_2 PF07992.14 CRG87678.1 - 1.9e-34 119.3 0.0 2.6e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG87678.1 - 9.1e-15 55.0 0.1 2e-11 44.3 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG87678.1 - 1.3e-08 34.8 0.0 0.12 11.9 0.0 3.6 2 1 2 4 4 4 3 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG87678.1 - 2.6e-08 33.5 0.0 1.3e-07 31.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG87678.1 - 4.1e-07 29.5 0.4 2.6e-06 26.8 0.2 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 CRG87678.1 - 2.6e-05 23.3 0.1 0.51 9.1 0.0 3.1 2 1 1 3 3 3 2 Tryptophan halogenase NAD_binding_7 PF13241.6 CRG87678.1 - 6.6e-05 23.3 0.0 0.026 14.9 0.0 3.0 3 0 0 3 3 3 1 Putative NAD(P)-binding NAD_binding_9 PF13454.6 CRG87678.1 - 0.00017 21.6 0.7 0.13 12.3 0.0 3.8 3 1 1 4 4 4 1 FAD-NAD(P)-binding TrkA_N PF02254.18 CRG87678.1 - 0.00031 21.0 0.0 0.85 9.9 0.0 3.4 3 0 0 3 3 3 1 TrkA-N domain NAD_binding_8 PF13450.6 CRG87678.1 - 0.00079 19.6 0.0 1.1 9.5 0.0 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Sacchrp_dh_NADP PF03435.18 CRG87678.1 - 0.043 14.1 0.1 4.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF1188 PF06690.11 CRG87678.1 - 0.057 13.0 0.0 8 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) FSH1 PF03959.13 CRG87678.1 - 0.13 11.9 0.7 0.99 9.0 0.4 2.2 2 0 0 2 2 2 0 Serine hydrolase (FSH1) AAA_12 PF13087.6 CRG87679.1 - 8.8e-38 129.9 0.0 1.4e-37 129.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CRG87679.1 - 7.9e-23 81.6 3.8 3.6e-22 79.4 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CRG87679.1 - 1.4e-09 38.0 0.0 1.3e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CRG87679.1 - 1.9e-08 34.7 0.1 2.4e-07 31.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 CRG87679.1 - 7.1e-06 25.9 0.7 0.0043 16.8 0.0 3.5 4 0 0 4 4 4 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 CRG87679.1 - 5.7e-05 23.2 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 CRG87679.1 - 0.00095 18.8 0.6 0.0063 16.1 0.0 2.5 4 0 0 4 4 4 1 UvrD/REP helicase N-terminal domain DEAD PF00270.29 CRG87679.1 - 0.0011 18.7 0.1 0.0039 17.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 CRG87679.1 - 0.007 15.8 0.0 0.021 14.3 0.0 1.8 1 0 0 1 1 1 1 PhoH-like protein DUF2075 PF09848.9 CRG87679.1 - 0.007 15.6 0.1 0.35 10.1 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 CRG87679.1 - 0.07 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain FliG_N PF14842.6 CRG87679.1 - 0.08 13.5 0.2 0.18 12.4 0.2 1.6 1 0 0 1 1 1 0 FliG N-terminal domain AAA_22 PF13401.6 CRG87679.1 - 0.13 12.5 0.0 1 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CRG87679.1 - 0.17 11.8 0.0 0.68 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 CRG87680.1 - 9.5e-57 191.3 0.0 1.8e-32 112.7 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG87680.1 - 7.6e-52 176.6 20.0 7.9e-34 117.6 3.4 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG87680.1 - 4.2e-08 32.9 3.0 0.017 14.6 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG87680.1 - 2.4e-06 27.6 1.7 0.025 14.4 0.1 3.6 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CRG87680.1 - 4.1e-06 26.9 0.1 0.022 14.9 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG87680.1 - 3.6e-05 23.7 0.1 0.42 10.5 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CRG87680.1 - 0.00014 22.1 1.8 4.7 7.5 0.0 3.8 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CRG87680.1 - 0.00019 21.9 0.6 0.74 10.2 0.0 3.2 3 0 0 3 3 2 2 AAA ATPase domain AAA_29 PF13555.6 CRG87680.1 - 0.00028 20.6 0.6 0.7 9.7 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG87680.1 - 0.0003 21.4 11.3 0.0047 17.5 0.1 3.6 4 0 0 4 4 3 2 AAA domain IstB_IS21 PF01695.17 CRG87680.1 - 0.011 15.5 0.3 2 8.1 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_25 PF13481.6 CRG87680.1 - 0.012 15.2 0.6 0.73 9.4 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CRG87680.1 - 0.013 15.2 0.4 0.71 9.6 0.0 2.8 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 CRG87680.1 - 0.014 14.4 0.3 0.046 12.8 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 CRG87680.1 - 0.019 14.2 0.6 4.3 6.6 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 CRG87680.1 - 0.02 15.3 0.7 7.7 7.0 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CRG87680.1 - 0.03 14.9 0.9 9.1 6.8 0.0 3.5 4 0 0 4 4 3 0 AAA domain DUF87 PF01935.17 CRG87680.1 - 0.032 14.3 1.5 0.38 10.8 0.1 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 CRG87680.1 - 0.11 11.9 0.2 12 5.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 CRG87680.1 - 0.18 11.4 1.6 0.43 10.1 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 CRG87680.1 - 0.18 12.0 0.5 12 6.2 0.1 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 CRG87680.1 - 0.22 10.9 1.0 2.8 7.2 0.2 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 CRG87680.1 - 0.5 10.3 1.8 6 6.8 0.1 2.4 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 CRG87680.1 - 0.66 10.0 3.3 17 5.4 0.0 3.3 3 0 0 3 3 3 0 Dynamin family AAA_15 PF13175.6 CRG87680.1 - 2.3 7.8 6.1 3.6 7.2 0.1 3.1 4 0 0 4 4 4 0 AAA ATPase domain UQ_con PF00179.26 CRG87681.1 - 2.9e-38 130.7 0.0 3.8e-38 130.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 CRG87681.1 - 0.041 13.5 0.0 0.083 12.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 CRG87681.1 - 0.17 12.2 0.5 0.3 11.4 0.4 1.6 1 1 0 1 1 1 0 RWD domain CRAL_TRIO PF00650.20 CRG87682.1 - 1.7e-25 89.6 0.0 2.2e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG87682.1 - 3.2e-11 43.2 0.0 8.2e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain SNase PF00565.17 CRG87683.1 - 2.8e-74 246.5 0.1 3.3e-25 88.6 0.0 5.6 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 CRG87683.1 - 4.7e-25 88.0 0.0 1.7e-24 86.2 0.0 2.0 2 0 0 2 2 2 1 Tudor domain SMN PF06003.12 CRG87683.1 - 7.8e-07 28.6 0.0 1.6e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Agenet PF05641.12 CRG87683.1 - 0.0066 16.9 0.6 0.05 14.1 0.1 2.9 4 0 0 4 4 4 1 Agenet domain BPL_LplA_LipB PF03099.19 CRG87683.1 - 0.022 14.7 0.0 0.05 13.5 0.0 1.5 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family Sod_Cu PF00080.20 CRG87684.1 - 3.2e-47 160.3 5.9 3.7e-47 160.1 5.9 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TAL_FSA PF00923.19 CRG87685.1 - 1.6e-93 313.2 0.2 1.9e-93 313.0 0.2 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Beach PF02138.18 CRG87686.1 - 3.2e-120 400.7 0.1 1.4e-119 398.5 0.0 2.0 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 CRG87686.1 - 2.1e-11 43.8 0.1 5.9e-11 42.3 0.1 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 CRG87686.1 - 3.9e-09 36.8 0.0 8.3e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 CRG87686.1 - 8e-05 23.3 3.2 0.18 12.7 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat RIX1 PF08167.12 CRG87686.1 - 0.14 11.8 0.4 2.5 7.8 0.0 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Peptidase_S8 PF00082.22 CRG87687.1 - 5.8e-35 121.0 12.5 9.3e-35 120.3 12.5 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 CRG87687.1 - 1.9e-20 73.3 0.1 4.7e-20 72.1 0.1 1.7 1 0 0 1 1 1 1 Peptidase inhibitor I9 EMC1_C PF07774.13 CRG87688.1 - 9.5e-77 257.5 0.0 2.2e-76 256.3 0.0 1.6 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 CRG87688.1 - 4.7e-34 118.0 12.9 5.6e-30 104.7 1.6 3.4 4 1 0 4 4 4 2 PQQ-like domain PQQ PF01011.21 CRG87688.1 - 6.8e-06 25.8 4.9 2 8.5 0.0 6.3 6 0 0 6 6 6 2 PQQ enzyme repeat DUF1479 PF07350.12 CRG87689.1 - 3.3e-167 556.5 0.0 3.8e-167 556.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) adh_short PF00106.25 CRG87690.1 - 8.8e-33 113.4 0.0 1.2e-32 113.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87690.1 - 1.8e-24 86.6 0.0 3.3e-24 85.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PilM PF07419.12 CRG87690.1 - 0.015 15.5 0.0 0.028 14.6 0.0 1.3 1 0 0 1 1 1 0 PilM KR PF08659.10 CRG87690.1 - 0.018 14.9 0.0 0.98 9.3 0.0 2.2 2 0 0 2 2 2 0 KR domain Aa_trans PF01490.18 CRG87691.1 - 1.5e-96 323.6 17.1 1.5e-96 323.6 17.1 1.3 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 CRG87691.1 - 2.4e-06 26.8 20.2 4.7e-06 25.9 20.2 1.5 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family ORMDL PF04061.14 CRG87691.1 - 0.94 9.3 5.2 0.47 10.3 0.6 2.7 2 1 0 2 2 2 0 ORMDL family Bax1-I PF01027.20 CRG87692.1 - 1.5e-51 175.2 28.8 1.7e-51 175.0 28.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF5504 PF17608.2 CRG87692.1 - 0.00011 22.2 6.8 0.00011 22.2 6.8 2.3 1 1 1 2 2 2 1 Family of unknown function (DUF5504) DUF2721 PF11026.8 CRG87692.1 - 0.4 10.6 0.0 0.4 10.6 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) DUF2070 PF09843.9 CRG87692.1 - 1.5 7.0 22.4 1.9 6.7 22.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EXS PF03124.14 CRG87693.1 - 1.3e-79 267.9 22.4 2.2e-71 240.9 13.9 2.1 1 1 1 2 2 2 2 EXS family SPX PF03105.19 CRG87693.1 - 2.9e-77 261.2 2.9 2.9e-77 261.2 2.9 2.2 2 0 0 2 2 2 1 SPX domain Abhydrolase_1 PF00561.20 CRG87695.1 - 1.7e-24 86.9 0.1 4.3e-24 85.5 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 CRG87695.1 - 8.2e-23 79.8 0.1 2.1e-22 78.5 0.1 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 CRG87695.1 - 0.00063 19.1 0.0 0.14 11.4 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 CRG87695.1 - 0.015 15.0 0.1 0.28 10.8 0.1 2.2 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Pet191_N PF10203.9 CRG87697.1 - 9.1e-28 96.4 3.9 1.1e-27 96.0 3.9 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 CRG87697.1 - 0.00034 20.6 0.5 0.32 11.1 0.0 2.3 2 0 0 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like COBRA PF04833.15 CRG87697.1 - 0.0023 17.9 0.3 0.0027 17.6 0.3 1.1 1 0 0 1 1 1 1 COBRA-like protein DUF3375 PF11855.8 CRG87697.1 - 0.07 12.1 0.0 0.07 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) PAN_3 PF08277.12 CRG87697.1 - 0.12 12.2 0.3 0.23 11.3 0.3 1.5 1 0 0 1 1 1 0 PAN-like domain CX9C PF16860.5 CRG87697.1 - 0.13 12.3 6.5 3.5 7.7 0.6 2.7 1 1 2 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DDOST_48kD PF03345.14 CRG87698.1 - 1.3e-154 515.1 0.0 1.5e-154 514.9 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta DUF928 PF06051.12 CRG87698.1 - 0.053 13.4 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) IMS PF00817.20 CRG87702.1 - 3.9e-37 127.6 0.0 7.6e-35 120.1 0.0 2.7 1 1 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CRG87702.1 - 7.5e-16 58.9 0.1 7.8e-15 55.6 0.0 2.2 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 CRG87702.1 - 4.7e-15 54.9 1.4 9.2e-15 53.9 1.4 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 CRG87702.1 - 0.017 15.4 0.1 0.037 14.3 0.1 1.6 1 0 0 1 1 1 0 IMS family HHH motif RA PF00788.23 CRG87703.1 - 0.29 11.8 0.1 0.29 11.8 0.1 2.6 2 0 0 2 2 2 0 Ras association (RalGDS/AF-6) domain WSC PF01822.19 CRG87704.1 - 2.4e-08 34.0 9.3 2.4e-08 34.0 9.3 2.2 2 1 0 2 2 2 1 WSC domain Podoplanin PF05808.11 CRG87704.1 - 0.0018 18.4 3.0 0.004 17.3 3.0 1.5 1 0 0 1 1 1 1 Podoplanin DUF4690 PF15756.5 CRG87704.1 - 0.01 16.4 6.4 0.033 14.8 6.4 1.9 1 0 0 1 1 1 0 Small Novel Rich in Cartilage DUF3592 PF12158.8 CRG87704.1 - 0.02 14.9 1.7 0.046 13.8 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3592) PTP_tm PF18861.1 CRG87704.1 - 0.027 14.5 0.1 0.041 13.9 0.1 1.3 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF2207 PF09972.9 CRG87704.1 - 0.062 12.1 0.0 0.079 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM65 PF10507.9 CRG87704.1 - 0.09 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 65 GST_N_4 PF17172.4 CRG87706.1 - 5.6e-20 71.9 0.0 8.5e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Tom37 PF10568.9 CRG87706.1 - 0.00011 22.5 0.0 0.00017 21.9 0.0 1.2 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 CRG87706.1 - 0.0017 18.1 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG87706.1 - 0.017 15.1 0.5 0.087 12.9 0.4 2.3 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Ras PF00071.22 CRG87707.1 - 4.7e-52 175.9 0.0 5.6e-52 175.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG87707.1 - 4.7e-19 68.8 0.2 8.7e-19 67.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG87707.1 - 8e-10 38.4 0.0 9.5e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG87707.1 - 2.3e-05 24.1 0.1 0.00025 20.6 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CRG87707.1 - 0.00013 22.0 0.0 0.00022 21.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG87707.1 - 0.001 19.0 0.2 1.4 8.8 0.1 2.2 1 1 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CRG87707.1 - 0.031 14.6 0.5 0.55 10.5 0.2 2.4 2 1 0 2 2 2 0 AAA domain Carboxyl_trans PF01039.22 CRG87708.1 - 2.9e-139 464.9 0.1 3.5e-139 464.6 0.1 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Plasmodium_Vir PF05795.11 CRG87709.1 - 7.3 5.9 8.2 11 5.3 8.2 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Acyl-CoA_dh_1 PF00441.24 CRG87710.1 - 1.5e-38 132.4 3.6 2.3e-38 131.7 3.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CRG87710.1 - 5.5e-32 110.8 0.1 1.2e-31 109.7 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CRG87710.1 - 1.3e-26 92.6 0.1 2.8e-26 91.6 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CRG87710.1 - 1.1e-14 54.8 1.8 2.1e-14 54.0 1.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CRG87710.1 - 0.0014 18.4 0.0 0.0051 16.5 0.0 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal CPSase_L_D2 PF02786.17 CRG87711.1 - 1e-74 250.6 0.0 1.8e-74 249.8 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 CRG87711.1 - 2.8e-36 123.9 0.0 1.1e-35 121.9 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 CRG87711.1 - 3.7e-35 120.8 0.0 8.1e-35 119.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 CRG87711.1 - 2.9e-17 62.3 1.4 1.7e-16 59.8 0.4 2.5 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CRG87711.1 - 3.9e-10 39.6 0.0 9.4e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CRG87711.1 - 9e-10 38.4 0.0 1.9e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 CRG87711.1 - 4.6e-06 26.4 0.0 0.01 15.7 0.0 2.8 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 CRG87711.1 - 8.6e-06 25.9 0.0 1.9e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain GCV_H PF01597.19 CRG87711.1 - 0.0013 18.6 0.2 0.0064 16.4 0.1 2.2 2 0 0 2 2 2 1 Glycine cleavage H-protein HlyD_3 PF13437.6 CRG87711.1 - 0.0028 18.3 0.0 2 9.2 0.0 2.8 2 0 0 2 2 2 1 HlyD family secretion protein GARS_A PF01071.19 CRG87711.1 - 0.004 16.9 0.0 0.0069 16.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATPgrasp_ST PF14397.6 CRG87711.1 - 0.0052 16.1 0.0 0.0098 15.2 0.0 1.3 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 CRG87711.1 - 0.011 15.3 0.0 0.043 13.4 0.0 1.9 1 1 0 1 1 1 0 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 CRG87711.1 - 0.022 14.3 0.0 0.062 12.9 0.0 1.8 1 0 0 1 1 1 0 ATP-grasp domain adh_short_C2 PF13561.6 CRG87712.1 - 3.1e-55 187.3 0.0 4.6e-55 186.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87712.1 - 1.1e-38 132.7 0.1 1.5e-38 132.3 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87712.1 - 1.5e-12 47.8 0.1 2.3e-12 47.2 0.1 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CRG87712.1 - 0.012 15.1 0.1 1 8.7 0.0 2.1 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase DUF1752 PF08550.10 CRG87713.1 - 7.2e-08 32.1 0.8 1.5e-07 31.1 0.8 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) MARVEL PF01284.23 CRG87714.1 - 4.6e-09 36.5 2.3 6.8e-09 35.9 2.3 1.3 1 0 0 1 1 1 1 Membrane-associating domain VIT1 PF01988.19 CRG87714.1 - 0.0032 17.4 0.0 0.0036 17.2 0.0 1.2 1 0 0 1 1 1 1 VIT family PHD PF00628.29 CRG87716.1 - 2.5e-09 36.9 2.1 5.8e-09 35.7 2.1 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CRG87716.1 - 0.0038 16.8 3.5 0.006 16.1 3.5 1.3 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 CRG87716.1 - 0.11 12.5 1.3 0.3 11.1 1.3 1.7 1 0 0 1 1 1 0 CW-type Zinc Finger C1_1 PF00130.22 CRG87716.1 - 2.9 7.8 4.9 2.7 7.9 0.5 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) eIF-5a PF01287.20 CRG87717.1 - 2.9e-05 24.1 0.0 6.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Sdh_cyt PF01127.22 CRG87717.1 - 4.6 7.3 5.8 1.6 8.8 0.3 2.3 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Abhydrolase_6 PF12697.7 CRG87718.1 - 1.2e-13 52.1 2.0 3.8e-12 47.3 2.0 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG87718.1 - 2.7e-10 40.4 0.1 7.4e-08 32.3 0.1 2.2 2 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG87718.1 - 0.00017 20.9 0.0 0.01 15.1 0.1 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF4466 PF14725.6 CRG87718.1 - 0.11 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4466) SRR1 PF07985.12 CRG87720.1 - 7.5e-16 57.9 0.1 1.4e-15 57.1 0.1 1.5 1 0 0 1 1 1 1 SRR1 RRP7 PF12923.7 CRG87720.1 - 0.0034 17.5 0.6 0.015 15.4 0.6 2.0 1 1 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Glyco_hydro_17 PF00332.18 CRG87721.1 - 2.6e-07 30.6 4.0 5.2e-05 23.0 1.3 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 Glyco_hydro_72 PF03198.14 CRG87721.1 - 0.13 11.5 0.1 0.23 10.7 0.1 1.4 1 0 0 1 1 1 0 Glucanosyltransferase FAD_binding_3 PF01494.19 CRG87724.1 - 2.1e-10 40.4 0.1 1.9e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain SE PF08491.10 CRG87724.1 - 0.059 12.4 0.0 1.9 7.5 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase Glyco_transf_34 PF05637.12 CRG87725.1 - 0.00035 20.4 0.2 0.0017 18.1 0.0 2.0 2 1 0 2 2 2 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 CRG87725.1 - 0.024 14.2 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF273 Nucleotid_trans PF03407.16 CRG87725.1 - 0.13 12.2 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase E1-E2_ATPase PF00122.20 CRG87726.1 - 5.6e-36 123.8 19.8 7.8e-31 107.0 0.2 3.2 2 1 1 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 CRG87726.1 - 3.8e-26 91.9 8.3 3.8e-26 91.9 8.3 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 CRG87726.1 - 1e-19 70.0 0.3 3e-19 68.5 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 CRG87726.1 - 4.1e-18 66.5 0.1 2.1e-13 51.1 0.0 3.4 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CRG87726.1 - 1.6e-13 50.5 0.0 3.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CRG87726.1 - 2.3e-05 24.3 0.7 0.005 16.6 0.9 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Wzy_C PF04932.15 CRG87726.1 - 0.051 13.2 0.2 0.051 13.2 0.2 2.7 3 0 0 3 3 3 0 O-Antigen ligase MgtE PF01769.16 CRG87726.1 - 8 6.9 12.1 16 5.9 0.0 3.5 3 0 0 3 3 3 0 Divalent cation transporter adh_short_C2 PF13561.6 CRG87727.1 - 1.8e-60 204.4 1.7 2.1e-60 204.2 1.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87727.1 - 8e-49 165.8 1.2 1.1e-48 165.3 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87727.1 - 1.7e-10 41.1 0.2 2.3e-10 40.7 0.2 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG87727.1 - 0.00052 19.3 0.2 0.00075 18.7 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 CRG87727.1 - 0.016 15.8 1.6 0.032 14.8 1.6 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Epimerase PF01370.21 CRG87727.1 - 0.071 12.6 0.2 0.099 12.1 0.2 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Vac14_Fig4_bd PF11916.8 CRG87728.1 - 2e-80 268.7 8.9 2e-80 268.7 8.9 1.8 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 CRG87728.1 - 1.6e-43 147.2 0.0 9.4e-42 141.5 0.0 3.5 4 0 0 4 4 4 1 Vacuolar 14 Fab1-binding region DHHC PF01529.20 CRG87728.1 - 2.3e-25 89.3 3.2 2.3e-25 89.3 3.2 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase HEAT_EZ PF13513.6 CRG87728.1 - 4e-08 33.6 2.0 0.0022 18.5 0.0 5.1 4 1 1 5 5 5 1 HEAT-like repeat HEAT PF02985.22 CRG87728.1 - 9.6e-06 25.4 0.9 0.003 17.7 0.0 4.8 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 CRG87728.1 - 0.00027 21.0 0.7 0.22 11.5 0.2 3.3 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CRG87728.1 - 0.011 16.1 0.4 1.4 9.4 0.0 3.9 4 1 0 4 4 4 0 HEAT repeats DUF4131 PF13567.6 CRG87728.1 - 0.03 14.0 2.1 0.083 12.5 2.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF3385 PF11865.8 CRG87728.1 - 0.045 13.7 0.0 5.8 6.8 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) Activator-TraM PF11657.8 CRG87728.1 - 0.3 10.9 3.1 0.67 9.8 0.8 2.4 2 0 0 2 2 2 0 Transcriptional activator TraM Rad54_N PF08658.10 CRG87729.1 - 2.3e-58 197.3 0.8 5.3e-57 192.9 0.6 2.3 2 0 0 2 2 2 1 Rad54 N terminal SNF2_N PF00176.23 CRG87729.1 - 1.4e-56 191.7 0.0 2.1e-56 191.1 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG87729.1 - 4.9e-16 59.1 0.0 1.6e-15 57.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG87729.1 - 9.2e-08 32.3 0.0 1.7e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CRG87729.1 - 0.0012 18.1 0.0 0.0086 15.3 0.0 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Mito_carr PF00153.27 CRG87730.1 - 4.6e-47 157.9 0.1 3.2e-18 65.4 0.0 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein Wzy_C PF04932.15 CRG87730.1 - 0.044 13.4 0.1 0.095 12.3 0.1 1.6 1 1 0 1 1 1 0 O-Antigen ligase zf-C2H2_jaz PF12171.8 CRG87731.1 - 2.5e-10 40.4 4.2 2.5e-10 40.4 4.2 1.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-U1 PF06220.12 CRG87731.1 - 0.059 13.2 1.8 0.11 12.2 0.8 1.9 2 0 0 2 2 2 0 U1 zinc finger zf-C2H2_2 PF12756.7 CRG87731.1 - 0.067 13.5 3.7 0.23 11.8 3.5 1.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 CRG87731.1 - 0.42 11.6 2.8 0.33 11.9 1.0 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-met PF12874.7 CRG87731.1 - 3.1 8.3 5.4 1.7 9.2 2.3 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Aconitase PF00330.20 CRG87732.1 - 1.4e-151 505.6 0.0 1.7e-151 505.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CRG87732.1 - 1.7e-44 151.3 0.0 2.9e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain BLACT_WH PF17778.1 CRG87733.1 - 4.2e-21 74.7 0.0 9.9e-21 73.5 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B PF00753.27 CRG87733.1 - 3.9e-14 53.1 7.4 3.4e-12 46.8 7.4 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG87733.1 - 3.9e-07 29.8 1.7 1e-06 28.4 1.7 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Glyco_transf_20 PF00982.21 CRG87734.1 - 1.1e-199 664.0 0.0 1.3e-199 663.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 CRG87734.1 - 0.032 13.9 0.1 0.073 12.8 0.1 1.6 1 0 0 1 1 1 0 Starch synthase catalytic domain ABC_membrane PF00664.23 CRG87735.1 - 3.1e-92 309.1 34.4 2.5e-51 175.0 13.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG87735.1 - 8.7e-68 227.1 0.0 2.7e-33 115.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG87735.1 - 7.6e-16 58.2 3.0 1.6e-05 24.4 0.2 4.3 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG87735.1 - 6.3e-09 36.4 1.4 0.0025 18.2 0.2 2.7 2 1 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 CRG87735.1 - 1.6e-07 30.5 5.5 0.0026 16.6 0.1 3.0 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_15 PF13175.6 CRG87735.1 - 1.5e-06 28.2 0.0 0.036 13.8 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CRG87735.1 - 2.9e-06 27.3 1.5 0.01 15.6 0.0 3.8 2 2 2 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CRG87735.1 - 3e-06 27.2 0.0 0.011 15.7 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CRG87735.1 - 3.5e-06 27.4 2.3 0.02 15.2 0.2 3.8 2 2 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 CRG87735.1 - 9.4e-06 25.0 0.0 0.084 12.1 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin AAA_29 PF13555.6 CRG87735.1 - 3.2e-05 23.6 1.8 0.18 11.6 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_30 PF13604.6 CRG87735.1 - 0.00012 21.9 5.4 0.084 12.6 0.8 4.0 3 1 0 3 3 3 2 AAA domain APS_kinase PF01583.20 CRG87735.1 - 0.00018 21.4 0.3 0.15 12.0 0.1 2.9 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_25 PF13481.6 CRG87735.1 - 0.00025 20.7 0.8 0.096 12.3 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CRG87735.1 - 0.00042 20.5 0.0 1.4 9.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 CRG87735.1 - 0.00082 19.0 0.6 0.15 11.7 0.1 2.9 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_18 PF13238.6 CRG87735.1 - 0.0013 19.3 0.0 1.2 9.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 CRG87735.1 - 0.0066 15.7 0.0 3.2 6.8 0.0 2.2 2 0 0 2 2 2 2 G-protein alpha subunit AAA_5 PF07728.14 CRG87735.1 - 0.0072 16.3 0.1 2.3 8.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_23 PF13476.6 CRG87735.1 - 0.019 15.5 0.7 10 6.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CRG87735.1 - 0.049 13.9 1.2 0.92 9.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CRG87735.1 - 0.053 13.7 7.1 2.6 8.4 0.2 4.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PRK PF00485.18 CRG87735.1 - 0.096 12.4 0.0 4.9 6.8 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NB-ARC PF00931.22 CRG87735.1 - 0.23 10.6 0.4 7.7 5.6 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_17 PF13207.6 CRG87735.1 - 0.62 10.5 3.3 36 4.8 0.1 3.7 4 0 0 4 4 3 0 AAA domain ATPgrasp_N PF18130.1 CRG87736.1 - 1.5e-13 51.1 0.0 3.5e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp N-terminal domain ATP-grasp_4 PF13535.6 CRG87736.1 - 3.5e-13 49.4 0.0 8.9e-13 48.1 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CRG87736.1 - 0.00097 18.7 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CRG87736.1 - 0.0013 18.8 0.2 0.046 13.8 0.0 2.9 3 0 0 3 3 3 1 ATP-grasp domain Beta_elim_lyase PF01212.21 CRG87737.1 - 5.8e-38 130.8 0.0 7e-38 130.6 0.0 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CRG87737.1 - 3.1e-09 36.5 0.0 5.2e-09 35.7 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Pyridoxal_deC PF00282.19 CRG87737.1 - 0.055 12.2 0.1 0.075 11.7 0.1 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain bZIP_1 PF00170.21 CRG87738.1 - 0.2 11.7 6.3 0.59 10.3 6.3 1.7 1 0 0 1 1 1 0 bZIP transcription factor GFO_IDH_MocA PF01408.22 CRG87739.1 - 1.2e-10 42.3 0.0 2.3e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Aminotran_4 PF01063.19 CRG87740.1 - 3.8e-26 92.3 0.0 5.5e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV CTP_synth_N PF06418.14 CRG87741.1 - 5.7e-120 399.6 0.1 8.8e-120 398.9 0.1 1.3 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 CRG87741.1 - 1.2e-51 175.2 0.1 1.1e-50 172.0 0.1 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CRG87741.1 - 8.8e-05 22.4 0.2 0.076 12.8 0.1 2.4 2 0 0 2 2 2 2 Peptidase C26 CbiA PF01656.23 CRG87741.1 - 0.072 13.1 0.0 0.09 12.8 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF2469 PF10611.9 CRG87741.1 - 0.11 13.0 0.1 0.26 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2469) TauD PF02668.16 CRG87742.1 - 1e-40 140.3 0.1 1.3e-40 140.0 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ribosomal_S17 PF00366.20 CRG87743.1 - 3.1e-14 52.8 0.1 6.5e-14 51.8 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 AAA PF00004.29 CRG87744.1 - 4.4e-38 130.7 0.0 8.7e-38 129.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 CRG87744.1 - 7.3e-08 32.3 0.0 6.9e-06 26.0 0.0 3.2 3 0 0 3 3 3 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 CRG87744.1 - 2.4e-07 30.4 0.0 5.8e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 CRG87744.1 - 1.6e-05 25.2 0.2 0.00019 21.7 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 CRG87744.1 - 3.1e-05 24.2 0.2 9.7e-05 22.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CRG87744.1 - 8.7e-05 22.3 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CRG87744.1 - 0.00094 19.2 0.0 0.0034 17.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG87744.1 - 0.0016 18.9 3.0 0.003 18.0 0.2 2.8 3 1 0 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 CRG87744.1 - 0.0027 17.0 0.0 0.0045 16.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 CRG87744.1 - 0.004 16.6 0.1 0.0099 15.3 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 CRG87744.1 - 0.0049 16.6 0.0 0.0086 15.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 CRG87744.1 - 0.0089 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 CRG87744.1 - 0.02 15.1 0.0 0.044 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CRG87744.1 - 0.055 13.0 0.0 0.18 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CRG87744.1 - 0.059 13.4 0.0 0.15 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain TMF_TATA_bd PF12325.8 CRG87744.1 - 0.06 13.6 4.5 0.13 12.4 4.5 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding AAA_24 PF13479.6 CRG87744.1 - 0.071 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CRG87744.1 - 0.092 13.3 0.0 0.29 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CRG87744.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 CRG87744.1 - 0.12 12.0 0.0 0.33 10.7 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 CRG87744.1 - 0.12 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain LIM_bind PF01803.16 CRG87744.1 - 0.18 11.3 1.2 0.58 9.7 1.2 1.8 1 0 0 1 1 1 0 LIM-domain binding protein AAA_11 PF13086.6 CRG87744.1 - 1.5 8.5 0.0 1.5 8.5 0.0 3.0 4 0 0 4 4 3 0 AAA domain Mito_carr PF00153.27 CRG87745.1 - 3.1e-65 216.1 6.6 9.6e-23 79.9 0.2 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CRG87745.1 - 0.0076 15.4 3.1 0.12 11.5 0.1 3.3 2 1 0 3 3 3 1 Gammaproteobacterial serine protease Nucleos_tra2_C PF07662.13 CRG87746.1 - 8.6e-71 238.1 0.8 8.6e-71 238.1 0.8 2.8 3 0 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 CRG87746.1 - 2e-21 76.4 3.6 2e-21 76.4 3.6 3.0 4 0 0 4 4 3 1 Na+ dependent nucleoside transporter N-terminus IBR PF01485.21 CRG87746.1 - 2e-12 47.2 34.8 3.2e-12 46.5 4.5 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 CRG87746.1 - 0.00013 22.2 8.2 0.00013 22.2 8.2 3.5 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG87746.1 - 0.00022 21.0 27.1 0.006 16.4 7.2 3.5 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG87746.1 - 0.00045 20.0 28.2 0.003 17.4 6.1 3.5 3 0 0 3 3 3 3 Zinc finger, C3HC4 type (RING finger) UN_NPL4 PF11543.8 CRG87746.1 - 0.024 15.1 0.0 0.044 14.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-C3HC4_4 PF15227.6 CRG87746.1 - 0.36 11.0 17.8 0.14 12.4 0.5 3.7 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 CRG87746.1 - 0.45 10.5 28.5 0.025 14.6 10.2 3.3 3 0 0 3 3 3 0 zinc-RING finger domain DUF4687 PF15747.5 CRG87746.1 - 0.62 10.6 2.8 1.6 9.3 2.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4687) Zn_Tnp_IS91 PF14319.6 CRG87746.1 - 1.7 8.8 12.7 0.27 11.3 3.8 2.8 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_14 PF17978.1 CRG87746.1 - 4.4 7.8 12.1 0.044 14.2 2.4 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain ATG2_CAD PF13329.6 CRG87749.1 - 3.7e-45 153.4 0.1 1e-44 152.0 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 CRG87749.1 - 3.2e-31 107.5 0.0 1.3e-30 105.6 0.0 2.2 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 CRG87749.1 - 0.031 14.0 0.0 0.077 12.8 0.0 1.6 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal A_deaminase PF00962.22 CRG87750.1 - 6.3e-24 84.9 0.0 1.1e-23 84.2 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase DnaB_bind PF10410.9 CRG87750.1 - 0.15 12.2 0.0 0.51 10.6 0.0 1.8 1 0 0 1 1 1 0 DnaB-helicase binding domain of primase Acid_PPase PF12689.7 CRG87751.1 - 2e-69 232.8 0.0 2.3e-69 232.6 0.0 1.0 1 0 0 1 1 1 1 Acid Phosphatase WD40 PF00400.32 CRG87752.1 - 2.3e-40 135.8 19.4 2.2e-05 25.1 0.3 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 CRG87752.1 - 2.8e-10 39.9 0.1 6e-10 38.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG87752.1 - 7.9e-08 32.0 0.1 2e-07 30.7 0.1 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 CRG87752.1 - 9.2e-07 29.1 1.7 2 8.8 0.1 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 CRG87752.1 - 5e-05 23.3 0.0 0.87 9.7 0.0 4.5 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region F-box_4 PF15966.5 CRG87752.1 - 0.0036 17.2 0.0 0.021 14.7 0.0 2.2 2 0 0 2 2 2 1 F-box Nup160 PF11715.8 CRG87752.1 - 0.045 12.4 7.3 5.9 5.4 0.1 4.7 3 2 2 5 5 5 0 Nucleoporin Nup120/160 adh_short PF00106.25 CRG87753.1 - 2e-14 53.5 0.0 3.4e-14 52.8 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87753.1 - 1.2e-11 44.7 0.0 1.9e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase LRR_6 PF13516.6 CRG87753.1 - 0.00022 21.0 4.4 2.7 8.3 0.1 4.4 4 0 0 4 4 4 2 Leucine Rich repeat LRR_1 PF00560.33 CRG87753.1 - 0.0061 16.9 1.1 13 6.8 0.2 4.0 3 0 0 3 3 3 1 Leucine Rich Repeat LRR_4 PF12799.7 CRG87753.1 - 0.018 15.5 6.0 0.068 13.6 3.8 3.0 2 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG87753.1 - 0.062 13.1 3.3 0.51 10.1 3.4 2.5 1 1 0 1 1 1 0 Leucine rich repeat Pectate_lyase_3 PF12708.7 CRG87755.1 - 1.1e-05 25.4 1.5 0.00016 21.6 1.3 2.4 1 1 0 1 1 1 1 Pectate lyase superfamily protein Rieske PF00355.26 CRG87756.1 - 1.2e-10 41.2 0.0 1.9e-10 40.5 0.0 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 CRG87756.1 - 4.5e-07 29.8 0.0 6.5e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain SLAC1 PF03595.17 CRG87757.1 - 1e-70 238.6 43.7 1.2e-70 238.4 43.7 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Adeno_E3 PF06040.11 CRG87757.1 - 0.0099 16.0 0.7 4.3 7.5 0.1 2.8 3 0 0 3 3 3 2 Adenovirus E3 protein Pro_racemase PF05544.11 CRG87758.1 - 9.6e-121 402.8 0.0 1.1e-120 402.6 0.0 1.0 1 0 0 1 1 1 1 Proline racemase PhzC-PhzF PF02567.16 CRG87758.1 - 0.071 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Phenazine biosynthesis-like protein OCD_Mu_crystall PF02423.15 CRG87759.1 - 1e-06 27.9 0.0 1.4e-05 24.2 0.0 2.6 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Nuc_sug_transp PF04142.15 CRG87760.1 - 1.3e-74 251.2 4.0 1.8e-74 250.8 4.0 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 CRG87760.1 - 0.0075 16.4 9.3 0.0075 16.4 9.3 2.9 2 1 0 2 2 2 1 EamA-like transporter family EmrE PF13536.6 CRG87760.1 - 0.036 13.7 0.1 0.036 13.7 0.1 2.9 3 1 0 3 3 3 0 Putative multidrug resistance efflux transporter TPT PF03151.16 CRG87760.1 - 1.8 7.8 10.1 0.46 9.8 1.1 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family Sec63 PF02889.16 CRG87761.1 - 5.3e-32 111.0 0.0 8.2e-32 110.4 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 CRG87761.1 - 7.4e-27 94.2 0.0 1.8e-26 92.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG87761.1 - 3.3e-12 46.7 0.0 7.2e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG87761.1 - 5.1e-06 26.8 0.0 2.1e-05 24.8 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 CRG87761.1 - 0.00029 21.2 0.0 0.00068 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CRG87761.1 - 0.00068 19.9 0.0 0.0021 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG87761.1 - 0.0021 17.8 0.0 0.0039 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 CRG87761.1 - 0.026 15.1 0.1 0.061 13.9 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain T2SSE PF00437.20 CRG87761.1 - 0.045 12.8 0.0 0.091 11.8 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA PF00004.29 CRG87761.1 - 0.065 13.7 0.0 0.17 12.3 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.14 CRG87761.1 - 0.084 12.7 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Helicase UvrD-helicase PF00580.21 CRG87761.1 - 0.089 12.3 0.1 0.25 10.8 0.0 1.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Amidase_5 PF05382.13 CRG87761.1 - 0.18 11.7 0.1 0.38 10.6 0.1 1.5 1 0 0 1 1 1 0 Bacteriophage peptidoglycan hydrolase MMR_HSR1 PF01926.23 CRG87762.1 - 8.5e-19 67.7 0.0 1.4e-18 67.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG87762.1 - 5.4e-07 29.3 0.0 9e-07 28.5 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CRG87762.1 - 2e-05 24.6 0.1 0.0035 17.3 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CRG87762.1 - 0.00016 21.8 0.0 0.0059 16.7 0.0 2.4 2 0 0 2 2 2 1 Dynamin family GTP_EFTU PF00009.27 CRG87762.1 - 0.00018 21.1 0.0 0.0025 17.4 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 CRG87762.1 - 0.0003 20.3 0.1 0.00043 19.8 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 CRG87762.1 - 0.0044 16.7 0.0 0.0096 15.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 CRG87762.1 - 0.0069 16.1 1.0 0.021 14.6 1.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 CRG87762.1 - 0.026 13.8 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 AIG1 family Roc PF08477.13 CRG87762.1 - 0.07 13.3 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 CRG87762.1 - 0.084 12.1 0.0 0.17 11.2 0.0 1.4 1 1 0 1 1 1 0 Septin IIGP PF05049.13 CRG87762.1 - 0.12 11.4 0.1 0.3 10.1 0.1 1.6 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_23 PF13476.6 CRG87762.1 - 0.86 10.1 4.7 2.3 8.7 4.7 1.7 1 1 0 1 1 1 0 AAA domain Clat_adaptor_s PF01217.20 CRG87763.1 - 7.6e-42 142.6 0.8 3.9e-41 140.3 0.0 2.5 2 2 1 3 3 3 1 Clathrin adaptor complex small chain Ribosomal_L7Ae PF01248.26 CRG87763.1 - 3.1e-22 78.1 0.5 6.2e-22 77.1 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CLPTM1 PF05602.12 CRG87763.1 - 0.048 12.7 0.3 0.072 12.1 0.3 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) IFRD PF05004.13 CRG87764.1 - 4.2e-08 32.7 0.0 0.0065 15.6 0.0 2.4 2 0 0 2 2 2 2 Interferon-related developmental regulator (IFRD) HEAT_2 PF13646.6 CRG87764.1 - 7.1e-05 23.1 5.5 1.2 9.6 0.1 4.2 3 1 2 5 5 4 2 HEAT repeats MMS19_N PF14500.6 CRG87764.1 - 0.00012 21.8 1.7 0.031 13.9 0.2 3.5 2 2 2 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Cnd1 PF12717.7 CRG87764.1 - 0.00036 20.6 0.2 0.43 10.6 0.1 3.3 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 CRG87764.1 - 0.0015 17.1 2.8 0.024 13.2 2.8 2.4 1 1 0 1 1 1 1 Adaptin N terminal region CLASP_N PF12348.8 CRG87764.1 - 0.0036 16.9 0.0 0.031 13.8 0.0 2.4 2 0 0 2 2 2 1 CLASP N terminal HEAT PF02985.22 CRG87764.1 - 0.0065 16.6 3.9 2.8 8.5 0.3 5.3 6 0 0 6 6 6 1 HEAT repeat Golgin_A5 PF09787.9 CRG87764.1 - 0.073 12.5 11.5 0.18 11.2 11.5 1.6 1 0 0 1 1 1 0 Golgin subfamily A member 5 TAN PF11640.8 CRG87764.1 - 0.097 12.8 0.2 0.097 12.8 0.2 2.6 2 1 0 2 2 1 0 Telomere-length maintenance and DNA damage repair Exonuc_VII_L PF02601.15 CRG87764.1 - 0.13 11.8 4.1 0.1 12.2 1.8 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit Atg14 PF10186.9 CRG87764.1 - 0.53 9.3 7.1 1.1 8.3 7.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2353 PF09789.9 CRG87764.1 - 1.8 7.8 14.3 0.43 9.9 10.1 1.9 2 0 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF724 PF05266.14 CRG87764.1 - 9.3 6.0 11.0 20 4.9 11.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DAO PF01266.24 CRG87765.1 - 5.6e-40 138.0 0.4 6.8e-40 137.7 0.4 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG87765.1 - 2.6e-05 23.6 0.0 4.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 CRG87765.1 - 0.0002 21.6 0.0 0.0008 19.6 0.0 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG87765.1 - 0.0071 16.3 0.1 0.015 15.3 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG87765.1 - 0.011 14.9 0.1 0.045 12.8 0.0 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG87765.1 - 0.025 13.8 0.0 0.038 13.2 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG87765.1 - 0.1 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) MCRA PF06100.11 CRG87765.1 - 0.18 10.5 0.1 0.24 10.2 0.1 1.1 1 0 0 1 1 1 0 MCRA family Chorismate_bind PF00425.18 CRG87766.1 - 2.2e-89 299.5 0.0 3.1e-89 299.0 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 CRG87766.1 - 1.9e-28 99.5 0.0 2e-24 86.4 0.0 3.3 3 0 0 3 3 3 2 Anthranilate synthase component I, N terminal region DUF4681 PF15732.5 CRG87767.1 - 0.024 14.9 0.2 0.061 13.6 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4681) ATG16 PF08614.11 CRG87767.1 - 0.038 14.2 11.2 0.13 12.5 4.9 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Vps51 PF08700.11 CRG87767.1 - 0.1 12.7 0.8 0.75 9.9 0.2 2.3 2 0 0 2 2 2 0 Vps51/Vps67 DUF1664 PF07889.12 CRG87767.1 - 0.1 12.6 0.1 0.37 10.8 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) NiFeSe_Hases PF00374.19 CRG87767.1 - 0.12 11.2 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Nickel-dependent hydrogenase CLZ PF16526.5 CRG87767.1 - 3.4 8.1 6.0 5 7.6 0.5 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels WD40 PF00400.32 CRG87768.1 - 6.7e-09 36.2 6.7 0.14 13.1 0.0 6.7 6 1 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87768.1 - 7.7e-08 32.5 0.1 0.001 19.3 0.0 4.6 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 CRG87768.1 - 1.4e-06 28.0 0.0 3.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 CRG87768.1 - 4.3e-05 23.5 0.1 0.00016 21.6 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A SdiA-regulated PF06977.11 CRG87768.1 - 0.029 13.6 0.0 0.13 11.4 0.0 1.9 2 0 0 2 2 2 0 SdiA-regulated DUF1751 PF08551.10 CRG87769.1 - 1.1e-24 86.9 3.2 7.9e-22 77.7 1.8 2.4 2 0 0 2 2 2 2 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 CRG87769.1 - 7.7e-05 22.7 4.8 0.00011 22.2 1.4 2.3 2 0 0 2 2 2 1 Rhomboid family L51_S25_CI-B8 PF05047.16 CRG87770.1 - 3.4e-18 65.3 0.0 6.3e-18 64.4 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain CALM_bind PF16025.5 CRG87770.1 - 4.6 7.8 8.3 3.6 8.1 6.5 1.8 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding tRNA-synt_1 PF00133.22 CRG87771.1 - 3.7e-40 137.8 0.0 1.2e-28 99.8 0.0 3.6 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CRG87771.1 - 2.5e-16 60.0 0.0 5.2e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CRG87771.1 - 1.8e-14 53.3 0.1 2.3e-08 33.2 0.0 2.8 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CRG87771.1 - 1.4e-07 31.2 0.0 2.8e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain ENTH PF01417.20 CRG87772.1 - 1.2e-47 161.0 0.0 1.9e-47 160.4 0.0 1.3 1 0 0 1 1 1 1 ENTH domain DUF1720 PF08226.11 CRG87772.1 - 1.1e-05 25.8 57.7 2.6e-05 24.5 38.3 5.7 2 2 3 5 5 5 2 Domain of unknown function (DUF1720) ANTH PF07651.16 CRG87772.1 - 6.2e-05 22.1 0.0 8.8e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 ANTH domain UIM PF02809.20 CRG87772.1 - 6.4e-05 22.6 3.8 0.002 17.9 0.6 2.7 2 1 0 2 2 2 2 Ubiquitin interaction motif DUF4264 PF14084.6 CRG87772.1 - 0.0098 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4264) MMR_HSR1 PF01926.23 CRG87773.1 - 0.00013 22.1 0.0 0.12 12.4 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase ATPase-cat_bd PF12156.8 CRG87773.1 - 0.019 15.7 0.0 0.04 14.6 0.0 1.5 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase RsgA_GTPase PF03193.16 CRG87773.1 - 0.045 13.7 0.1 0.14 12.1 0.1 1.7 1 1 0 1 1 1 0 RsgA GTPase FYDLN_acid PF09538.10 CRG87773.1 - 0.048 14.3 2.0 0.11 13.2 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-AD PF07776.15 CRG87773.1 - 0.19 12.0 0.1 0.43 10.9 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Sde2_N_Ubi PF13019.6 CRG87774.1 - 9.2e-70 233.7 0.2 1.5e-69 233.0 0.2 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain S10_plectin PF03501.15 CRG87775.1 - 1.2e-41 140.7 0.1 1.5e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Peptidase_M20 PF01546.28 CRG87776.1 - 6.7e-30 104.3 0.3 9.2e-30 103.9 0.3 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG87776.1 - 1.9e-05 24.5 0.0 4.9e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CRG87776.1 - 0.014 15.1 0.0 3.5 7.2 0.0 2.2 2 0 0 2 2 2 0 Peptidase family M28 HIT PF01230.23 CRG87777.1 - 7.7e-24 84.3 0.1 1.1e-23 83.8 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 CRG87777.1 - 2.1e-08 34.7 0.0 3.3e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 CRG87777.1 - 0.00011 22.1 0.0 0.00014 21.7 0.0 1.1 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 PfkB PF00294.24 CRG87777.1 - 0.017 14.4 0.0 0.019 14.3 0.0 1.0 1 0 0 1 1 1 0 pfkB family carbohydrate kinase CRAL_TRIO PF00650.20 CRG87778.1 - 3.2e-43 147.2 0.0 5e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 CRG87778.1 - 2e-16 59.9 0.1 5.1e-16 58.6 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 CRG87778.1 - 2.1e-06 27.9 0.0 3.5e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Sororin PF09666.10 CRG87778.1 - 0.014 15.6 0.1 0.029 14.6 0.1 1.5 1 0 0 1 1 1 0 Sororin protein DASH_Dam1 PF08653.10 CRG87779.1 - 1.9e-29 101.3 2.3 2.5e-29 100.9 2.3 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 UCH PF00443.29 CRG87780.1 - 4.7e-48 163.9 0.9 4.7e-48 163.9 0.9 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG87780.1 - 1.5e-20 74.0 10.0 7.1e-20 71.8 7.4 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CRG87780.1 - 0.00017 21.8 0.9 0.00017 21.8 0.9 3.3 3 1 1 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein PID PF00640.23 CRG87780.1 - 1.8 8.6 6.9 12 5.9 0.1 3.0 3 0 0 3 3 3 0 Phosphotyrosine interaction domain (PTB/PID) Ytp1 PF10355.9 CRG87781.1 - 9.7e-111 369.4 12.4 9.7e-111 369.4 12.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CRG87781.1 - 6.4e-28 96.6 15.6 6.5e-28 96.6 7.9 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF2427) DUF3990 PF13151.6 CRG87781.1 - 0.00013 21.6 0.0 0.00025 20.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3990) GMC_oxred_N PF00732.19 CRG87782.1 - 2.1e-51 175.1 0.0 5.3e-50 170.5 0.0 2.1 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG87782.1 - 5.4e-33 114.5 0.0 9.4e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase DAO PF01266.24 CRG87782.1 - 2e-05 24.3 0.0 0.00036 20.2 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG87782.1 - 0.00025 20.2 0.0 0.011 14.8 0.0 2.3 2 1 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CRG87782.1 - 0.00089 19.4 1.3 0.0067 16.6 0.5 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG87782.1 - 0.0022 17.3 0.0 0.0044 16.3 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG87782.1 - 0.0037 16.2 0.0 0.0052 15.7 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase Lycopene_cycl PF05834.12 CRG87782.1 - 0.0042 16.2 0.1 0.0075 15.4 0.1 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG87782.1 - 0.072 12.3 0.1 6.6 5.9 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_31 PF01055.26 CRG87783.1 - 4.5e-122 408.4 3.5 6.3e-122 407.9 3.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG87783.1 - 8.6e-31 106.5 0.2 1.7e-30 105.6 0.2 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Rotavirus_VP7 PF05868.11 CRG87783.1 - 0.046 13.1 0.1 0.38 10.1 0.0 2.1 1 1 1 2 2 2 0 Rotavirus major outer capsid protein VP7 Aldo_ket_red PF00248.21 CRG87784.1 - 4.2e-54 183.7 0.0 5.1e-54 183.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family TPP_enzyme_N PF02776.18 CRG87785.1 - 1.5e-20 73.5 0.0 2.9e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG87785.1 - 5.2e-12 45.8 0.0 1.4e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PEP_mutase PF13714.6 CRG87786.1 - 8.8e-43 146.5 0.1 1.3e-42 145.9 0.1 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase TauD PF02668.16 CRG87787.1 - 1.4e-24 87.4 0.1 1.9e-24 86.9 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CRG87788.1 - 2.2e-17 63.1 34.6 2.2e-17 63.1 34.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily BT1 PF03092.16 CRG87788.1 - 0.24 9.6 7.1 0.049 11.9 0.6 2.2 2 0 0 2 2 2 0 BT1 family Cytochrom_B_C PF00032.17 CRG87788.1 - 0.58 10.5 6.7 0.096 13.0 1.3 2.3 2 1 1 3 3 3 0 Cytochrome b(C-terminal)/b6/petD GST_N_3 PF13417.6 CRG87789.1 - 0.00032 21.0 0.0 0.00088 19.6 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG87789.1 - 0.0032 17.7 0.0 0.0075 16.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG87789.1 - 0.0044 17.2 0.0 0.007 16.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG87789.1 - 0.0054 16.9 0.0 0.013 15.7 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG87789.1 - 0.025 14.6 0.1 0.055 13.5 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain DLH PF01738.18 CRG87790.1 - 3.2e-34 118.4 0.0 3.8e-34 118.2 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CRG87790.1 - 0.016 14.9 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold BAAT_C PF08840.11 CRG87790.1 - 0.03 14.2 0.1 6.2 6.7 0.0 2.2 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF915 PF06028.11 CRG87790.1 - 0.044 13.1 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Rhomboid PF01694.22 CRG87791.1 - 2e-15 57.1 10.8 2e-15 57.1 10.8 1.5 2 0 0 2 2 2 1 Rhomboid family DUF2070 PF09843.9 CRG87791.1 - 1.5 7.0 9.7 2 6.6 9.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Gaa1 PF04114.14 CRG87792.1 - 4.4e-181 603.3 12.7 5.2e-181 603.0 12.7 1.0 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component PCI PF01399.27 CRG87793.1 - 1.6e-08 35.0 0.0 3.7e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 PCI domain Rpn9_C PF18261.1 CRG87793.1 - 1.5e-05 24.4 0.8 3.2e-05 23.4 0.8 1.5 1 0 0 1 1 1 1 Rpn9 C-terminal helix Methyltransf_23 PF13489.6 CRG87794.1 - 8.2e-13 48.5 0.0 1.1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87794.1 - 4e-12 46.2 0.0 6.4e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87794.1 - 5.3e-12 46.3 0.0 1.6e-11 44.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG87794.1 - 2.3e-10 41.0 0.0 5.1e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87794.1 - 4.2e-09 37.0 0.0 8e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG87794.1 - 4.7e-05 22.8 0.0 7.1e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 CRG87794.1 - 0.00032 20.7 0.0 0.00055 20.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CRG87794.1 - 0.0059 15.6 0.0 0.015 14.3 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) DREV PF05219.12 CRG87794.1 - 0.13 11.4 0.0 0.4 9.7 0.0 1.7 1 1 1 2 2 2 0 DREV methyltransferase PCMT PF01135.19 CRG87794.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.5 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Lambda_CIII PF02061.16 CRG87794.1 - 0.18 11.9 0.0 0.43 10.7 0.0 1.6 1 0 0 1 1 1 0 Lambda Phage CIII NmrA PF05368.13 CRG87795.1 - 5.1e-15 55.7 0.0 7.4e-15 55.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG87795.1 - 4e-14 52.9 0.0 6.1e-14 52.3 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG87795.1 - 5.4e-14 52.2 0.0 1.2e-13 51.1 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG87795.1 - 1.6e-10 40.5 0.0 2.4e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG87795.1 - 2.6e-08 33.7 0.2 5e-07 29.4 0.1 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG87795.1 - 3.9e-07 29.4 0.0 3.8e-06 26.2 0.0 2.4 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG87795.1 - 0.00031 20.0 0.1 0.031 13.4 0.1 2.7 1 1 1 3 3 3 1 Male sterility protein adh_short PF00106.25 CRG87795.1 - 0.0006 19.3 0.0 0.00096 18.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87795.1 - 0.07 13.0 0.0 1.5 8.7 0.0 2.3 1 1 0 1 1 1 0 KR domain ApbA PF02558.16 CRG87795.1 - 0.079 12.6 0.0 0.4 10.3 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Mog1 PF04603.12 CRG87796.1 - 5e-32 111.2 0.0 8e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Kinesin PF00225.23 CRG87797.1 - 5.6e-82 275.3 0.0 8.3e-82 274.8 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CRG87797.1 - 5.3e-22 78.4 0.0 1.4e-21 77.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding HHH PF00633.23 CRG87797.1 - 0.00017 21.3 0.1 0.002 17.9 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_3 PF12836.7 CRG87797.1 - 0.0049 17.1 0.0 0.014 15.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 CRG87797.1 - 0.006 17.2 0.1 0.26 11.9 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain TPR_15 PF13429.6 CRG87797.1 - 0.021 14.0 0.2 0.036 13.3 0.2 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3140 PF11338.8 CRG87797.1 - 0.066 13.7 0.9 0.17 12.4 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3140) HR1 PF02185.16 CRG87797.1 - 5 7.3 8.0 1.2 9.2 2.5 2.6 2 0 0 2 2 2 0 Hr1 repeat Sec23_trunk PF04811.15 CRG87798.1 - 7.9e-69 231.9 0.0 1.4e-68 231.1 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Pkinase PF00069.25 CRG87798.1 - 2.5e-66 223.8 0.0 3.3e-66 223.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87798.1 - 4e-31 108.2 0.0 5.9e-31 107.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Sec23_helical PF04815.15 CRG87798.1 - 7.7e-24 83.5 0.0 2.8e-23 81.7 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CRG87798.1 - 1.5e-16 60.1 4.6 2.8e-16 59.3 4.6 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 CRG87798.1 - 1.8e-16 60.6 0.0 5.3e-16 59.1 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 CRG87798.1 - 1.3e-07 31.4 0.0 3.3e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat Kdo PF06293.14 CRG87798.1 - 0.0022 17.4 0.7 0.0041 16.5 0.2 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CRG87798.1 - 0.031 13.2 0.0 0.05 12.5 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Vps36-NZF-N PF16988.5 CRG87798.1 - 0.034 13.6 0.2 0.071 12.5 0.2 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Kinase-like PF14531.6 CRG87798.1 - 0.059 12.7 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HEM4 PF02602.15 CRG87799.1 - 5.8e-38 130.5 0.0 1.9e-37 128.8 0.0 1.7 1 1 0 1 1 1 1 Uroporphyrinogen-III synthase HemD Peptidase_M1 PF01433.20 CRG87800.1 - 5.4e-42 143.8 0.8 7.9e-42 143.3 0.8 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 CRG87800.1 - 3e-32 111.0 0.0 6.6e-32 109.9 0.0 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 CRG87800.1 - 2e-24 86.8 0.0 3.1e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain NYN PF01936.18 CRG87801.1 - 4.5e-05 24.0 0.0 0.00027 21.4 0.0 2.5 1 1 0 1 1 1 1 NYN domain HSP9_HSP12 PF04119.12 CRG87802.1 - 2e-24 85.7 13.0 2e-24 85.7 13.0 1.7 2 0 0 2 2 2 1 Heat shock protein 9/12 DUF2884 PF11101.8 CRG87802.1 - 0.084 12.4 0.6 0.096 12.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) YtxH PF12732.7 CRG87802.1 - 0.089 13.3 6.5 0.051 14.1 2.8 2.3 2 1 0 2 2 2 0 YtxH-like protein AAA_13 PF13166.6 CRG87803.1 - 9.1e-06 24.6 9.0 1.3e-05 24.1 9.0 1.2 1 0 0 1 1 1 1 AAA domain COG2 PF06148.11 CRG87803.1 - 0.0024 17.9 1.3 0.0024 17.9 1.3 2.7 2 1 1 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Snapin_Pallidin PF14712.6 CRG87803.1 - 0.016 15.6 10.2 0.069 13.6 3.6 3.5 1 1 2 3 3 3 0 Snapin/Pallidin GIT_CC PF16559.5 CRG87803.1 - 0.039 13.8 0.5 0.039 13.8 0.5 3.1 3 1 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor NPV_P10 PF05531.12 CRG87803.1 - 0.051 14.0 6.9 0.88 10.1 0.0 3.6 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Lyase_1 PF00206.20 CRG87803.1 - 0.24 10.7 6.9 0.43 9.9 6.8 1.4 1 1 0 1 1 1 0 Lyase DivIC PF04977.15 CRG87803.1 - 0.33 10.7 17.7 0.14 12.0 1.0 3.9 4 1 1 5 5 5 0 Septum formation initiator POTRA_TamA_1 PF17243.2 CRG87803.1 - 0.33 11.1 8.2 3.5 7.8 0.0 3.4 3 0 0 3 3 3 0 POTRA domain TamA domain 1 DUF4407 PF14362.6 CRG87803.1 - 0.34 10.2 12.9 0.033 13.6 5.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fzo_mitofusin PF04799.13 CRG87803.1 - 0.5 9.9 5.3 1.8 8.1 0.9 2.5 1 1 0 2 2 2 0 fzo-like conserved region FapA PF03961.13 CRG87803.1 - 0.62 8.6 14.2 0.11 11.1 1.8 2.9 1 1 2 3 3 3 0 Flagellar Assembly Protein A Takusan PF04822.13 CRG87803.1 - 0.83 9.6 5.1 1.2 9.0 0.3 3.0 2 1 0 2 2 2 0 Takusan LPD39 PF18858.1 CRG87803.1 - 1.1 9.3 10.6 0.18 11.9 3.9 2.6 2 1 0 2 2 2 0 Large polyvalent protein associated domain 39 FadA PF09403.10 CRG87803.1 - 1.6 9.3 14.2 0.78 10.3 0.3 4.0 3 1 1 4 4 4 0 Adhesion protein FadA Pox_A_type_inc PF04508.12 CRG87803.1 - 1.8 8.6 4.7 10 6.2 0.0 3.8 3 1 0 3 3 3 0 Viral A-type inclusion protein repeat APG6_N PF17675.1 CRG87803.1 - 2.5 8.6 27.2 1.2 9.6 7.2 3.1 1 1 2 3 3 3 0 Apg6 coiled-coil region FAM76 PF16046.5 CRG87803.1 - 3.1 7.1 9.4 4.4 6.6 2.4 2.3 1 1 1 2 2 2 0 FAM76 protein GAS PF13851.6 CRG87803.1 - 3.3 7.0 19.7 0.039 13.3 2.2 2.9 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding ArAE_2_N PF10337.9 CRG87803.1 - 3.4 6.6 6.9 0.49 9.4 3.1 1.6 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal Prefoldin_2 PF01920.20 CRG87803.1 - 3.5 7.6 19.3 4.4 7.3 0.7 4.4 3 1 2 5 5 5 0 Prefoldin subunit Phage_GPO PF05929.11 CRG87803.1 - 3.6 7.1 13.9 15 5.1 0.3 2.3 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase SYCE1 PF15233.6 CRG87803.1 - 3.9 7.5 21.0 6.1 6.9 3.1 3.5 2 1 1 3 3 3 0 Synaptonemal complex central element protein 1 TssO PF17561.2 CRG87803.1 - 4.1 7.5 8.3 1.6 8.8 3.2 2.6 2 1 1 3 3 2 0 Type VI secretion system, TssO HALZ PF02183.18 CRG87803.1 - 5.2 7.4 8.8 9 6.6 1.7 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper Nsp1_C PF05064.13 CRG87803.1 - 7.2 6.5 13.6 13 5.6 0.2 3.5 1 1 1 3 3 3 0 Nsp1-like C-terminal region HIP1_clath_bdg PF16515.5 CRG87803.1 - 7.2 7.3 20.4 7 7.3 1.5 3.4 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-H PF05837.12 CRG87803.1 - 7.8 7.0 18.3 4.3 7.8 2.5 3.3 2 1 1 3 3 3 0 Centromere protein H (CENP-H) ParB PF08775.10 CRG87803.1 - 8.7 6.8 9.8 1.7 9.1 0.7 2.9 3 0 0 3 3 3 0 ParB family BRE1 PF08647.11 CRG87803.1 - 9.8 6.3 17.3 2.6 8.2 2.1 3.7 3 2 1 4 4 4 0 BRE1 E3 ubiquitin ligase COG6 PF06419.11 CRG87804.1 - 2.5e-204 680.1 3.2 2.8e-204 679.9 3.2 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Transcrip_act PF04949.13 CRG87804.1 - 0.0083 16.0 1.3 0.024 14.5 1.3 1.8 1 0 0 1 1 1 1 Transcriptional activator Hydrolase_3 PF08282.12 CRG87804.1 - 0.053 13.2 0.3 0.1 12.3 0.3 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF4698 PF15769.5 CRG87804.1 - 0.056 12.5 2.4 0.043 12.9 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4698) COG2 PF06148.11 CRG87804.1 - 0.45 10.6 5.4 0.27 11.3 1.4 2.7 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 NIF3 PF01784.18 CRG87805.1 - 1.3e-56 192.0 0.0 1.7e-56 191.6 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) BolA PF01722.18 CRG87806.1 - 3.6e-18 65.6 0.0 1.2e-17 63.9 0.0 1.8 1 1 1 2 2 2 1 BolA-like protein Redoxin PF08534.10 CRG87807.1 - 1.7e-30 105.7 0.1 2.1e-30 105.4 0.1 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 CRG87807.1 - 1.1e-08 35.0 0.0 1.4e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family PA PF02225.22 CRG87807.1 - 0.057 13.5 0.1 0.23 11.5 0.0 2.0 1 1 0 1 1 1 0 PA domain HSF_DNA-bind PF00447.17 CRG87808.1 - 2.9e-31 107.9 1.8 6.8e-31 106.7 1.8 1.7 1 0 0 1 1 1 1 HSF-type DNA-binding Response_reg PF00072.24 CRG87808.1 - 5.4e-23 81.3 0.0 1e-22 80.4 0.0 1.5 1 0 0 1 1 1 1 Response regulator receiver domain FTO_CTD PF12934.7 CRG87808.1 - 0.078 12.7 0.2 0.41 10.4 0.0 2.2 2 0 0 2 2 2 0 FTO C-terminal domain DivIC PF04977.15 CRG87808.1 - 0.32 10.8 2.0 0.63 9.9 2.0 1.4 1 0 0 1 1 1 0 Septum formation initiator Cnn_1N PF07989.11 CRG87808.1 - 0.44 10.7 2.3 0.95 9.7 2.3 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 W2 PF02020.18 CRG87809.1 - 1.6e-20 73.0 6.9 1.6e-20 73.0 6.9 3.0 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 CRG87809.1 - 1.5e-12 46.7 20.8 3e-05 23.6 0.3 4.1 1 1 4 5 5 5 5 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG87809.1 - 1.1e-07 31.5 8.9 0.016 14.9 0.1 3.8 2 1 1 3 3 3 3 Hexapeptide repeat of succinyl-transferase NTP_transferase PF00483.23 CRG87809.1 - 8.8e-06 25.5 0.0 2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 CRG87809.1 - 7.8e-05 21.0 1.3 0.00073 17.8 0.9 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 CRG87809.1 - 0.0049 17.2 0.0 0.0095 16.3 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 CRG87809.1 - 0.084 11.8 0.1 0.15 11.0 0.1 1.4 1 0 0 1 1 1 0 L-fucokinase Methyltransf_11 PF08241.12 CRG87810.1 - 4.5e-11 43.2 0.0 2.1e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87810.1 - 4.7e-10 40.0 0.2 1.6e-09 38.3 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87810.1 - 9.5e-08 32.0 0.0 1.5e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87810.1 - 5.9e-07 30.1 0.0 1.6e-06 28.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG87810.1 - 0.0027 17.5 0.0 0.0059 16.5 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain UQ_con PF00179.26 CRG87811.1 - 2.8e-48 163.1 0.0 3.4e-48 162.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 CRG87811.1 - 2e-05 24.3 0.0 3.1e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 CRG87811.1 - 0.00028 21.2 0.1 0.0004 20.6 0.1 1.5 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 CRG87811.1 - 0.0044 16.9 0.0 0.0064 16.4 0.0 1.4 1 0 0 1 1 1 1 UEV domain Pkinase PF00069.25 CRG87812.1 - 9.4e-61 205.5 0.0 1.3e-60 205.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87812.1 - 5.2e-29 101.3 0.0 7.7e-29 100.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG87812.1 - 7.2e-10 38.6 0.0 1.5e-09 37.6 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CRG87812.1 - 0.0058 16.0 0.0 0.013 14.9 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG87812.1 - 0.077 12.9 0.3 0.35 10.8 0.1 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family F-box-like PF12937.7 CRG87813.1 - 2.1e-09 37.1 0.5 4.2e-09 36.1 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG87813.1 - 1.9e-06 27.6 0.3 4.5e-06 26.4 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CRG87813.1 - 0.13 12.1 0.1 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 F-box DUF4357 PF14267.6 CRG87813.1 - 0.59 10.1 2.6 5.2 7.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4357) DHBP_synthase PF00926.19 CRG87814.1 - 5.3e-77 257.7 0.0 6.7e-77 257.4 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase TFA2_Winged_2 PF18121.1 CRG87815.1 - 2.4e-23 81.6 4.1 3.1e-23 81.2 0.5 2.6 3 0 0 3 3 3 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 CRG87815.1 - 8.9e-18 64.4 0.1 4.7e-17 62.0 0.0 2.3 2 1 0 2 2 2 1 TFIIE beta subunit core domain PhoQ_Sensor PF08918.10 CRG87815.1 - 0.14 12.0 0.2 0.23 11.3 0.2 1.3 1 0 0 1 1 1 0 PhoQ Sensor TPR_MLP1_2 PF07926.12 CRG87816.1 - 1.8e-33 115.3 32.3 1.8e-33 115.3 32.3 18.9 8 6 9 17 17 17 8 TPR/MLP1/MLP2-like protein KASH_CCD PF14662.6 CRG87816.1 - 1e-05 25.5 28.9 1e-05 25.5 28.9 14.1 6 4 7 13 13 13 4 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.9 CRG87816.1 - 0.0021 18.1 17.0 0.0021 18.1 17.0 17.6 6 4 10 17 17 17 8 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Wzy_C_2 PF11846.8 CRG87816.1 - 0.0042 17.0 0.5 0.028 14.4 0.5 2.5 1 0 0 1 1 1 1 Virulence factor membrane-bound polymerase, C-terminal Hexapep PF00132.24 CRG87817.1 - 3e-09 36.2 4.8 7.5e-05 22.3 0.7 3.7 2 2 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG87817.1 - 0.00012 21.8 2.3 0.00056 19.6 0.8 2.6 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase CN_hydrolase PF00795.22 CRG87818.1 - 3.1e-58 197.2 0.0 4.6e-58 196.6 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Beta-lactamase PF00144.24 CRG87818.1 - 1.7e-47 162.3 0.3 4e-47 161.1 0.3 1.6 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CRG87818.1 - 4.7e-11 43.1 0.0 1e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Ribosomal_L31e PF01198.19 CRG87819.1 - 9e-34 115.6 1.9 6.9e-16 58.3 0.5 2.2 2 0 0 2 2 2 2 Ribosomal protein L31e Ran_BP1 PF00638.18 CRG87820.1 - 5.7e-09 36.3 0.0 1e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Nucleoporin_FG PF13634.6 CRG87820.1 - 1.7e-05 25.5 65.6 8.4e-05 23.3 21.1 11.0 2 2 6 8 8 8 4 Nucleoporin FG repeat region Peptidase_M24 PF00557.24 CRG87821.1 - 1.9e-40 138.8 0.0 2.5e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 YL1 PF05764.13 CRG87821.1 - 0.0044 17.2 5.4 0.0063 16.7 5.4 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 CRG87821.1 - 5.7 5.1 4.9 7.2 4.8 4.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_43 PF04616.14 CRG87822.1 - 4.8e-22 78.6 1.2 7e-22 78.1 1.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 adh_short PF00106.25 CRG87823.1 - 5.7e-22 78.1 0.0 1.3e-19 70.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87823.1 - 3.1e-13 49.8 0.0 8.3e-13 48.4 0.0 1.7 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG87823.1 - 2.4e-05 24.3 0.0 4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Borealin PF10512.9 CRG87823.1 - 0.022 14.7 0.0 0.048 13.6 0.0 1.5 1 0 0 1 1 1 0 Cell division cycle-associated protein 8 Peptidase_M24 PF00557.24 CRG87824.1 - 1.5e-45 155.5 0.0 1.7e-45 155.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Pectate_lyase_3 PF12708.7 CRG87825.1 - 1.5e-88 296.3 27.1 5e-78 261.8 11.1 2.9 3 1 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CRG87825.1 - 4.7e-07 29.4 5.4 0.00072 19.2 0.5 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase SCP2 PF02036.17 CRG87826.1 - 4.6e-24 84.8 0.5 1e-23 83.7 0.5 1.6 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 CRG87826.1 - 0.00015 22.0 0.2 0.00034 20.9 0.2 1.6 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SUIM_assoc PF16619.5 CRG87826.1 - 0.004 17.2 1.2 0.004 17.2 1.2 2.3 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 PAP2 PF01569.21 CRG87827.1 - 1.6e-26 92.7 0.2 1.6e-26 92.7 0.2 1.9 2 1 0 2 2 2 1 PAP2 superfamily Med7 PF05983.11 CRG87828.1 - 2e-63 214.0 2.4 2.6e-63 213.6 2.4 1.1 1 0 0 1 1 1 1 MED7 protein ABC2_membrane PF01061.24 CRG87829.1 - 3.9e-85 284.5 45.8 1.1e-45 155.7 20.4 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 CRG87829.1 - 6.9e-38 130.2 0.0 2.3e-18 67.0 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CRG87829.1 - 2.6e-26 91.3 8.5 8.4e-25 86.5 0.0 3.7 3 0 0 3 3 3 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 CRG87829.1 - 2.2e-10 40.2 32.5 3.5e-05 23.1 6.0 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 CRG87829.1 - 2e-06 28.3 0.3 0.0093 16.4 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CRG87829.1 - 3e-05 24.0 0.2 0.0041 17.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 CRG87829.1 - 6.6e-05 22.6 0.1 0.0029 17.2 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CRG87829.1 - 0.00023 21.3 0.1 0.83 9.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CRG87829.1 - 0.00039 21.0 0.0 1.1 9.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CRG87829.1 - 0.00044 20.5 0.4 0.75 10.1 0.2 2.9 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CRG87829.1 - 0.00058 19.5 0.3 0.094 12.5 0.1 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_trans_N PF14510.6 CRG87829.1 - 0.0027 18.3 0.1 0.009 16.6 0.1 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_28 PF13521.6 CRG87829.1 - 0.0045 17.3 1.7 0.89 9.8 0.6 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CRG87829.1 - 0.013 15.1 1.8 2 8.0 0.3 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 CRG87829.1 - 0.05 13.5 0.3 2.5 8.0 0.1 2.3 2 0 0 2 2 2 0 NACHT domain MMR_HSR1 PF01926.23 CRG87829.1 - 0.11 12.6 0.9 18 5.4 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 CRG87829.1 - 0.13 11.5 0.6 4.5 6.5 0.3 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 CRG87829.1 - 0.15 11.8 0.9 5.2 6.7 0.4 2.3 2 0 0 2 2 2 0 AAA domain Aft1_OSA PF11785.8 CRG87829.1 - 0.27 11.7 1.4 0.71 10.4 1.4 1.6 1 0 0 1 1 1 0 Aft1 osmotic stress response (OSM) domain D-ser_dehydrat PF14031.6 CRG87830.1 - 3.6e-23 82.0 0.3 1e-22 80.6 0.1 1.9 2 0 0 2 2 2 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 CRG87830.1 - 1.8e-10 40.8 0.0 2.9e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Gti1_Pac2 PF09729.9 CRG87830.1 - 0.00022 21.4 0.1 0.00041 20.5 0.1 1.4 1 0 0 1 1 1 1 Gti1/Pac2 family AA_kinase PF00696.28 CRG87830.1 - 0.073 12.7 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Amino acid kinase family Acyl_transf_3 PF01757.22 CRG87833.1 - 4.7e-21 75.2 32.1 2.5e-20 72.9 32.1 1.9 1 1 0 1 1 1 1 Acyltransferase family GST_N_5 PF18485.1 CRG87833.1 - 0.092 13.1 0.2 0.35 11.2 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain Ribosomal_L34 PF00468.17 CRG87833.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L34 Fringe PF02434.16 CRG87834.1 - 0.00011 21.7 0.0 0.00017 21.1 0.0 1.2 1 0 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 CRG87834.1 - 0.0042 17.0 3.5 0.0094 15.8 2.8 2.0 2 0 0 2 2 2 1 PAN domain CYLD_phos_site PF16607.5 CRG87834.1 - 0.11 12.3 0.6 2.2 8.1 0.1 2.3 2 0 0 2 2 2 0 Phosphorylation region of CYLD, unstructured p450 PF00067.22 CRG87835.1 - 5.6e-50 170.4 0.0 7.2e-50 170.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG87836.1 - 6.9e-38 130.5 62.6 1.2e-31 109.9 47.3 3.7 1 1 1 2 2 2 2 Major Facilitator Superfamily HNH_2 PF13391.6 CRG87836.1 - 1.1e-14 54.3 0.7 2.4e-14 53.2 0.7 1.6 1 0 0 1 1 1 1 HNH endonuclease Sugar_tr PF00083.24 CRG87836.1 - 2.4e-13 49.7 28.4 5.1e-09 35.5 7.3 3.2 2 1 1 3 3 3 3 Sugar (and other) transporter 2-Hacid_dh_C PF02826.19 CRG87837.1 - 5.8e-53 178.9 0.0 9.4e-53 178.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG87837.1 - 2.2e-26 92.1 0.0 2.6e-26 91.9 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG87837.1 - 0.0025 18.0 0.1 0.0042 17.3 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CRG87837.1 - 0.029 14.9 0.0 0.063 13.9 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Ldh_2 PF02615.14 CRG87838.1 - 6.6e-112 373.9 0.2 7.5e-112 373.8 0.2 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Mito_carr PF00153.27 CRG87839.1 - 7.5e-67 221.3 2.0 3.9e-23 81.2 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_11 PF08241.12 CRG87841.1 - 1.3e-14 54.6 0.0 2.4e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87841.1 - 5.5e-14 52.6 0.0 9.7e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87841.1 - 2.9e-10 40.8 0.0 5.8e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG87841.1 - 1.2e-06 28.5 0.0 3.2e-06 27.1 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87841.1 - 8.4e-06 25.6 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG87841.1 - 9.6e-05 21.8 0.0 0.00014 21.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DREV PF05219.12 CRG87841.1 - 0.0012 18.0 0.0 0.0021 17.2 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase CMAS PF02353.20 CRG87841.1 - 0.0052 16.1 0.0 0.0079 15.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_15 PF09445.10 CRG87841.1 - 0.12 12.0 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase tRNA_U5-meth_tr PF05958.11 CRG87841.1 - 0.13 11.2 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase RrnaAD PF00398.20 CRG87841.1 - 0.22 10.6 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Kelch_5 PF13854.6 CRG87843.1 - 3.5e-12 46.0 0.6 1.9e-11 43.7 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 CRG87843.1 - 1.5e-06 27.7 0.0 0.035 13.7 0.2 3.1 2 1 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 CRG87843.1 - 0.0038 17.5 0.3 0.051 13.9 0.1 2.9 2 0 0 2 2 2 1 Kelch motif SKG6 PF08693.10 CRG87843.1 - 0.008 15.6 5.2 0.021 14.2 5.2 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_4 PF13418.6 CRG87843.1 - 0.019 15.0 4.2 1.7 8.7 0.1 4.4 4 0 0 4 4 4 0 Galactose oxidase, central domain AbiGi PF10899.8 CRG87845.1 - 0.013 15.4 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative abortive phage resistance protein AbiGi, antitoxin Nudix_hydro PF18290.1 CRG87845.1 - 0.14 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Nudix hydrolase domain Fungal_trans PF04082.18 CRG87846.1 - 0.00043 19.4 0.2 0.00076 18.6 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Transp_cyt_pur PF02133.15 CRG87847.1 - 2e-73 247.7 40.7 4.2e-73 246.6 40.7 1.5 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Amdase PF17645.1 CRG87848.1 - 2.7e-17 63.1 0.1 3.1e-17 62.9 0.1 1.1 1 0 0 1 1 1 1 Arylmalonate decarboxylase Amidohydro_1 PF01979.20 CRG87849.1 - 9e-23 81.1 0.0 1.3e-22 80.6 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG87849.1 - 4.7e-14 52.7 0.0 4e-07 29.9 0.1 3.0 4 0 0 4 4 4 2 Amidohydrolase family Urease_alpha PF00449.20 CRG87849.1 - 0.021 15.1 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain Aldedh PF00171.22 CRG87850.1 - 5.9e-110 367.9 1.0 2.3e-70 237.4 0.0 3.1 2 1 1 3 3 3 3 Aldehyde dehydrogenase family Fungal_trans PF04082.18 CRG87850.1 - 7.5e-17 61.2 0.5 1.6e-16 60.2 0.4 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain ABC_tran PF00005.27 CRG87851.1 - 3.4e-51 173.3 0.1 7.5e-24 84.8 0.0 3.1 3 0 0 3 3 3 2 ABC transporter ABC2_membrane PF01061.24 CRG87851.1 - 2.4e-45 154.6 40.1 6.6e-27 94.3 11.9 2.5 3 0 0 3 3 2 2 ABC-2 type transporter AAA_21 PF13304.6 CRG87851.1 - 3.4e-14 53.4 1.0 8.8e-05 22.5 0.1 4.3 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CRG87851.1 - 1.6e-09 37.9 1.4 0.0012 18.8 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 CRG87851.1 - 1.3e-08 34.6 2.2 0.00081 18.9 0.3 3.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG87851.1 - 1.1e-07 32.5 0.1 0.013 15.9 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CRG87851.1 - 2.1e-07 31.7 0.2 0.0033 17.9 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CRG87851.1 - 6.5e-06 25.8 1.9 0.068 12.9 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.6 CRG87851.1 - 3.3e-05 23.6 0.2 0.25 10.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CRG87851.1 - 6e-05 23.3 0.3 0.39 11.0 0.0 3.2 3 1 0 3 3 3 2 AAA domain AAA PF00004.29 CRG87851.1 - 0.00011 22.7 0.1 0.86 10.0 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 CRG87851.1 - 0.00015 21.9 4.1 0.094 12.8 0.1 3.2 3 0 0 3 3 3 2 50S ribosome-binding GTPase NACHT PF05729.12 CRG87851.1 - 0.00025 21.0 0.6 0.32 10.9 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_33 PF13671.6 CRG87851.1 - 0.0003 21.0 0.1 0.08 13.1 0.0 2.8 3 0 0 3 3 2 1 AAA domain cobW PF02492.19 CRG87851.1 - 0.00032 20.3 1.1 0.61 9.7 0.2 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CRG87851.1 - 0.00037 20.3 0.1 0.76 9.5 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CRG87851.1 - 0.001 19.0 0.4 1.7 8.6 0.1 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 CRG87851.1 - 0.0013 18.7 0.0 0.27 11.1 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea PDR_CDR PF06422.12 CRG87851.1 - 0.0043 16.9 0.2 0.0043 16.9 0.2 2.3 2 0 0 2 2 1 1 CDR ABC transporter RNA_helicase PF00910.22 CRG87851.1 - 0.005 17.2 0.3 3 8.3 0.1 2.7 2 0 0 2 2 2 1 RNA helicase Roc PF08477.13 CRG87851.1 - 0.0061 16.8 0.5 2.2 8.5 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 CRG87851.1 - 0.0071 16.6 1.5 2 8.7 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CRG87851.1 - 0.0079 16.8 0.0 0.87 10.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_15 PF13175.6 CRG87851.1 - 0.0089 15.8 0.4 2.4 7.8 0.1 2.9 3 0 0 3 3 3 1 AAA ATPase domain T2SSE PF00437.20 CRG87851.1 - 0.0093 15.1 0.1 2.4 7.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_24 PF13479.6 CRG87851.1 - 0.012 15.4 0.2 3.3 7.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 CRG87851.1 - 0.014 15.3 0.4 1.6 8.6 0.1 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PIF1 PF05970.14 CRG87851.1 - 0.016 14.4 0.1 0.54 9.4 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase AAA_19 PF13245.6 CRG87851.1 - 0.034 14.5 0.2 15 5.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain RuvB_N PF05496.12 CRG87851.1 - 0.044 13.5 0.3 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 CRG87851.1 - 0.06 12.9 1.1 9.1 5.8 0.1 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region PRK PF00485.18 CRG87851.1 - 0.07 12.9 0.9 4 7.1 0.1 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Dynamin_N PF00350.23 CRG87851.1 - 0.074 13.1 3.7 5.9 6.9 0.3 2.6 2 0 0 2 2 2 0 Dynamin family PduV-EutP PF10662.9 CRG87851.1 - 0.089 12.5 0.2 13 5.5 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 CRG87851.1 - 0.1 12.1 0.1 8.1 5.8 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein NTPase_1 PF03266.15 CRG87851.1 - 0.13 12.1 1.1 27 4.6 0.0 3.1 3 0 0 3 3 3 0 NTPase SbcCD_C PF13558.6 CRG87851.1 - 0.14 12.4 0.5 10 6.4 0.1 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SRPRB PF09439.10 CRG87851.1 - 0.2 11.1 0.4 11 5.5 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Zeta_toxin PF06414.12 CRG87851.1 - 0.27 10.5 1.2 7.5 5.8 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.18 CRG87851.1 - 0.27 10.6 2.5 4.4 6.6 0.4 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Pox_A32 PF04665.12 CRG87851.1 - 0.87 9.0 2.3 25 4.2 0.2 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein Aminotran_5 PF00266.19 CRG87852.1 - 7.6e-21 74.5 0.0 1.1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG87852.1 - 0.00065 19.1 0.1 0.00094 18.6 0.1 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family OKR_DC_1 PF01276.20 CRG87852.1 - 0.16 10.7 0.1 0.23 10.1 0.1 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain AA_permease PF00324.21 CRG87853.1 - 9.5e-123 410.3 33.6 1.1e-122 410.0 33.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG87853.1 - 1.1e-36 126.6 36.7 1.3e-36 126.4 36.7 1.0 1 0 0 1 1 1 1 Amino acid permease Lipase_GDSL PF00657.22 CRG87855.1 - 0.044 13.8 0.3 0.12 12.3 0.3 1.7 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Aspzincin_M35 PF14521.6 CRG87856.1 - 7.1e-27 94.7 2.3 7.1e-27 94.7 2.3 1.8 2 0 0 2 2 2 1 Lysine-specific metallo-endopeptidase Peptidase_M35 PF02102.15 CRG87856.1 - 2.2e-25 89.3 10.5 3.9e-25 88.5 10.5 1.3 1 1 0 1 1 1 1 Deuterolysin metalloprotease (M35) family HRXXH PF13933.6 CRG87856.1 - 3.8e-06 26.6 1.0 3.8e-06 26.6 1.0 2.1 2 0 0 2 2 2 1 Putative peptidase family Glyco_hydro_43 PF04616.14 CRG87857.1 - 2.9e-40 138.4 0.8 5.4e-40 137.5 0.8 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 Glyco_hydro_65N PF03636.15 CRG87858.1 - 2.1e-33 115.9 0.0 3.4e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 CRG87858.1 - 1.2e-22 80.3 0.7 1.3e-19 70.4 0.0 2.3 1 1 0 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 CRG87858.1 - 0.00012 21.9 0.2 0.002 18.0 0.2 2.8 3 0 0 3 3 3 1 Glycosyl hydrolase family 65, C-terminal domain Sugar_tr PF00083.24 CRG87861.1 - 1.8e-91 307.3 20.4 2.3e-91 306.9 20.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG87861.1 - 1.3e-20 73.6 35.1 9.8e-20 70.8 28.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG87862.1 - 1.8e-15 56.7 0.1 3.2e-15 55.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87862.1 - 1.5e-07 31.4 10.6 3.8e-07 30.1 10.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box PF00646.33 CRG87863.1 - 4.2e-05 23.3 0.2 0.00024 20.9 0.1 2.4 2 1 0 2 2 2 1 F-box domain F-box-like PF12937.7 CRG87863.1 - 0.00095 19.0 1.9 0.0042 17.0 1.4 2.5 2 1 0 2 2 2 1 F-box-like Alpha-L-AF_C PF06964.12 CRG87864.1 - 4.6e-27 95.2 0.0 1.2e-26 93.8 0.0 1.7 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain Lipase_GDSL_2 PF13472.6 CRG87864.1 - 9.5e-16 58.7 0.7 1.1e-12 48.8 0.6 2.6 2 0 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG87864.1 - 2.4e-07 30.9 0.0 5.5e-07 29.8 0.0 1.6 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Arylesterase PF01731.20 CRG87864.1 - 0.00017 21.7 0.0 0.0012 19.0 0.0 2.4 2 0 0 2 2 2 1 Arylesterase Glyco_hydro_3_C PF01915.22 CRG87865.1 - 9.8e-45 153.0 0.2 4.7e-44 150.8 0.0 2.2 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG87865.1 - 3.3e-37 128.6 0.0 7e-37 127.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG87865.1 - 3e-20 72.1 0.0 5.8e-20 71.2 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Fungal_trans_2 PF11951.8 CRG87866.1 - 2.7e-35 121.9 6.0 8.8e-35 120.2 6.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87866.1 - 1.6e-06 28.1 8.5 2.9e-06 27.3 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 CRG87867.1 - 9.7e-07 28.8 9.4 3e-06 27.2 9.4 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG87867.1 - 7.7e-05 21.7 5.7 0.0002 20.3 5.5 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF656 PF04920.12 CRG87867.1 - 0.045 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF656) adh_short PF00106.25 CRG87868.1 - 6.4e-22 78.0 0.6 9.1e-18 64.4 0.2 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG87868.1 - 9.7e-11 41.7 0.7 1.6e-09 37.7 0.2 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG87868.1 - 1e-06 28.8 0.0 1.9e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 CRG87868.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF4965 PF16335.5 CRG87869.1 - 5.2e-64 215.1 0.3 8.2e-64 214.4 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF5127 PF17168.4 CRG87869.1 - 2e-48 165.2 2.2 3e-48 164.6 2.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF1793 PF08760.11 CRG87869.1 - 4.7e-27 95.5 0.8 4e-26 92.5 1.1 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 CRG87869.1 - 7.9e-07 28.5 0.4 2.4e-06 27.0 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4964) Serpulina_VSP PF05540.11 CRG87869.1 - 0.017 14.2 0.1 1.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Serpulina hyodysenteriae variable surface protein Peptidase_A4 PF01828.17 CRG87870.1 - 4.2e-83 277.9 15.1 5.4e-83 277.6 15.1 1.1 1 0 0 1 1 1 1 Peptidase A4 family Sugar_tr PF00083.24 CRG87871.1 - 4.8e-42 144.4 26.7 1.7e-28 99.7 2.2 2.5 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG87871.1 - 5.6e-29 101.2 21.8 8.3e-19 67.7 11.4 2.8 2 1 0 3 3 3 2 Major Facilitator Superfamily OATP PF03137.20 CRG87871.1 - 0.41 8.9 7.9 0.076 11.3 0.8 2.9 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Pox_Ag35 PF03286.14 CRG87871.1 - 1.6 8.5 6.3 3.6 7.3 6.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 CRG87871.1 - 2.7 8.5 12.5 5.5 7.5 12.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 CRG87871.1 - 3.8 7.2 7.3 3 7.5 4.9 2.1 2 0 0 2 2 2 0 FAM176 family PNP_UDP_1 PF01048.20 CRG87872.1 - 3.7e-15 55.8 0.0 7.6e-15 54.8 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily ACOX PF01756.19 CRG87873.1 - 2.5e-48 164.0 0.1 2.2e-47 160.9 0.1 2.3 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 CRG87873.1 - 4.4e-25 88.7 1.1 9.9e-25 87.5 1.1 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 CRG87873.1 - 2.5e-11 43.6 0.0 7.1e-11 42.2 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CRG87873.1 - 7.1e-05 23.0 0.3 0.05 13.8 0.0 2.5 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Abhydrolase_6 PF12697.7 CRG87874.1 - 3.1e-21 77.0 0.1 3.7e-21 76.7 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG87874.1 - 9.8e-19 68.0 0.1 7.3e-18 65.1 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG87874.1 - 0.00047 19.5 0.0 0.00068 19.0 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CRG87874.1 - 0.0019 18.0 0.0 0.0046 16.7 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein Ser_hydrolase PF06821.13 CRG87874.1 - 0.048 13.5 0.0 0.08 12.8 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_5 PF12695.7 CRG87874.1 - 0.089 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 CRG87874.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF676 PF05057.14 CRG87874.1 - 0.17 11.4 0.0 0.31 10.5 0.0 1.5 1 1 0 1 1 1 0 Putative serine esterase (DUF676) DHquinase_I PF01487.15 CRG87875.1 - 2.2e-13 51.0 0.0 3.7e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_DH PF01488.20 CRG87875.1 - 6.6e-09 35.9 0.0 2.4e-08 34.1 0.0 1.8 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Shikimate_dh_N PF08501.11 CRG87875.1 - 0.0005 20.3 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 CRG87875.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase SDH_C PF18317.1 CRG87875.1 - 0.062 13.1 0.0 0.17 11.6 0.0 1.8 1 0 0 1 1 1 0 Shikimate 5'-dehydrogenase C-terminal domain F420_oxidored PF03807.17 CRG87875.1 - 0.086 13.4 0.0 0.28 11.8 0.0 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 CRG87875.1 - 0.16 12.3 0.0 0.8 10.0 0.0 2.1 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain UBA PF00627.31 CRG87877.1 - 0.024 14.6 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 UBA/TS-N domain Dak1_2 PF13684.6 CRG87877.1 - 0.093 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Pex14_N PF04695.13 CRG87877.1 - 0.26 11.9 0.0 0.32 11.7 0.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PLDc_2 PF13091.6 CRG87878.1 - 2e-15 56.8 0.1 1.9e-10 40.7 0.1 2.3 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 CRG87878.1 - 0.048 13.8 0.0 1.8 8.9 0.0 2.5 2 0 0 2 2 2 0 Phospholipase D Active site motif Zn_clus PF00172.18 CRG87879.1 - 8e-09 35.5 13.4 8e-09 35.5 13.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1688 PF07958.11 CRG87879.1 - 0.2 10.3 0.0 0.3 9.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) RTA1 PF04479.13 CRG87881.1 - 5e-38 130.8 9.9 6.7e-38 130.4 9.9 1.1 1 0 0 1 1 1 1 RTA1 like protein Fungal_trans_2 PF11951.8 CRG87882.1 - 7.4e-05 21.7 0.0 0.00097 18.0 0.0 2.0 2 0 0 2 2 2 2 Fungal specific transcription factor domain GH131_N PF18271.1 CRG87883.1 - 3.1e-47 161.4 0.2 3.5e-47 161.3 0.2 1.0 1 0 0 1 1 1 1 Glycoside hydrolase 131 catalytic N-terminal domain MFS_2 PF13347.6 CRG87884.1 - 5e-13 48.4 14.5 5e-13 48.4 14.5 2.1 1 1 1 2 2 2 1 MFS/sugar transport protein PUCC PF03209.15 CRG87884.1 - 5.7e-05 22.3 0.3 5.7e-05 22.3 0.3 2.1 2 1 0 2 2 2 1 PUCC protein DUF3989 PF13150.6 CRG87884.1 - 0.068 12.9 0.5 13 5.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) DUF3357 PF11837.8 CRG87884.1 - 1.1 9.7 3.1 1.8 9.1 0.5 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3357) 60KD_IMP PF02096.20 CRG87884.1 - 1.9 8.3 7.0 4.7 7.1 1.4 2.9 2 1 1 3 3 3 0 60Kd inner membrane protein ABC_tran PF00005.27 CRG87885.1 - 1.3e-53 181.2 0.0 2.3e-32 112.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG87885.1 - 1.7e-42 146.0 27.7 8.5e-26 91.2 16.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_16 PF13191.6 CRG87885.1 - 6.2e-09 36.5 1.8 0.0004 20.8 1.5 2.8 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CRG87885.1 - 2.2e-08 34.2 0.0 0.00074 19.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 CRG87885.1 - 1.8e-07 30.8 0.5 0.3 10.5 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 CRG87885.1 - 3.6e-06 27.0 0.1 0.0026 17.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 CRG87885.1 - 5.8e-06 27.0 0.0 0.013 16.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CRG87885.1 - 8.9e-06 26.0 0.0 0.28 11.5 0.1 2.8 2 1 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CRG87885.1 - 2.8e-05 23.8 0.1 0.38 10.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Zeta_toxin PF06414.12 CRG87885.1 - 3.3e-05 23.3 0.0 0.037 13.3 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_25 PF13481.6 CRG87885.1 - 3.6e-05 23.4 2.4 0.35 10.4 0.0 3.5 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 CRG87885.1 - 0.00093 19.0 0.0 0.77 9.5 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein Dynamin_N PF00350.23 CRG87885.1 - 0.0012 19.0 0.5 2.1 8.4 0.1 2.6 2 0 0 2 2 2 2 Dynamin family AAA PF00004.29 CRG87885.1 - 0.0016 18.9 0.0 0.52 10.7 0.0 3.1 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 CRG87885.1 - 0.002 18.3 0.4 1.9 8.7 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.6 CRG87885.1 - 0.0026 17.6 0.1 3 7.6 0.0 3.1 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 CRG87885.1 - 0.005 16.0 0.0 0.17 11.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 CRG87885.1 - 0.005 17.2 0.0 4.2 7.8 0.0 2.6 2 0 0 2 2 2 1 RNA helicase DUF87 PF01935.17 CRG87885.1 - 0.01 15.9 0.4 0.052 13.6 0.1 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain Roc PF08477.13 CRG87885.1 - 0.027 14.7 0.0 4.6 7.5 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 CRG87885.1 - 0.029 14.1 0.0 2.3 7.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CRG87885.1 - 0.032 13.9 0.4 11 5.6 0.8 2.8 2 1 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 CRG87885.1 - 0.041 13.3 0.1 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_7 PF12775.7 CRG87885.1 - 0.045 13.3 0.0 9.6 5.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 CRG87885.1 - 0.047 14.2 0.0 15 6.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 CRG87885.1 - 0.05 12.8 0.0 6.3 5.9 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 CRG87885.1 - 0.069 12.2 0.0 5 6.1 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CRG87885.1 - 0.072 12.4 0.0 2.3 7.5 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 CRG87885.1 - 0.075 12.9 0.2 4 7.3 0.1 2.4 2 0 0 2 2 2 0 NACHT domain AAA_27 PF13514.6 CRG87885.1 - 0.11 12.0 0.1 0.54 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 CRG87885.1 - 0.11 12.7 0.5 3.1 8.1 0.1 3.3 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TIP49 PF06068.13 CRG87885.1 - 0.18 11.0 0.0 0.44 9.7 0.0 1.6 2 0 0 2 2 1 0 TIP49 P-loop domain CbiA PF01656.23 CRG87885.1 - 0.18 11.8 0.0 4 7.5 0.0 2.7 3 0 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATPase_2 PF01637.18 CRG87885.1 - 0.22 11.4 0.0 7.1 6.5 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_15 PF13175.6 CRG87885.1 - 0.39 10.4 0.3 2.2 7.9 0.2 1.9 2 0 0 2 2 2 0 AAA ATPase domain AMP-binding PF00501.28 CRG87886.1 - 0 1036.0 0.0 2.1e-70 237.4 0.0 6.2 5 1 0 5 5 5 5 AMP-binding enzyme Condensation PF00668.20 CRG87886.1 - 1.6e-167 557.9 0.1 2.6e-43 148.4 0.0 6.0 5 2 0 5 5 5 5 Condensation domain PP-binding PF00550.25 CRG87886.1 - 5.3e-53 177.3 9.0 1.2e-10 41.6 0.1 6.3 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG87886.1 - 4e-19 69.4 0.1 0.0053 17.7 0.0 5.9 5 0 0 5 5 5 4 AMP-binding enzyme C-terminal domain DUF3328 PF11807.8 CRG87887.1 - 7e-24 84.8 0.7 1e-23 84.3 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CRG87888.1 - 2.8e-46 158.1 2.5 3.7e-46 157.7 2.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Mannosyl_trans PF05007.13 CRG87888.1 - 0.22 11.4 0.6 0.35 10.7 0.6 1.3 1 0 0 1 1 1 0 Mannosyltransferase (PIG-M) DUF938 PF06080.12 CRG87889.1 - 0.19 11.5 0.2 57 3.4 0.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF938) Methyltransf_23 PF13489.6 CRG87889.1 - 1.5 8.6 7.5 22 4.8 0.1 3.0 1 1 2 3 3 3 0 Methyltransferase domain DUF1269 PF06897.12 CRG87889.1 - 5.1 7.4 5.5 24 5.3 5.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1269) NAD_binding_8 PF13450.6 CRG87889.1 - 6.1 7.2 10.6 26 5.1 0.0 3.6 3 1 1 4 4 4 0 NAD(P)-binding Rossmann-like domain Spore_YtfJ PF09579.10 CRG87889.1 - 7.8 6.7 6.0 22 5.3 1.3 2.3 1 1 1 2 2 2 0 Sporulation protein YtfJ (Spore_YtfJ) Lyase_aromatic PF00221.19 CRG87890.1 - 1.4e-152 508.6 1.1 1.9e-152 508.2 1.1 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase ketoacyl-synt PF00109.26 CRG87892.1 - 3.6e-71 239.7 0.0 1e-70 238.2 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG87892.1 - 2.6e-50 171.3 0.0 4.7e-50 170.5 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG87892.1 - 6.9e-48 163.8 0.7 1.5e-47 162.6 0.7 1.6 1 1 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CRG87892.1 - 8.1e-47 159.4 0.1 5.6e-46 156.7 0.0 2.7 4 0 0 4 4 4 1 KR domain Ketoacyl-synt_C PF02801.22 CRG87892.1 - 2.4e-40 137.2 0.0 1e-39 135.2 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG87892.1 - 1.5e-17 64.0 0.1 3.4e-16 59.7 0.1 2.8 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG87892.1 - 1.5e-08 34.3 0.0 1e-07 31.6 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CRG87892.1 - 2.7e-07 30.8 0.1 9.1e-07 29.1 0.1 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 CRG87892.1 - 0.00023 21.9 0.0 0.00075 20.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain SAT PF16073.5 CRG87892.1 - 0.0087 15.8 0.3 0.11 12.2 0.8 2.5 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Thiolase_N PF00108.23 CRG87892.1 - 0.022 14.1 0.1 0.059 12.7 0.1 1.7 1 0 0 1 1 1 0 Thiolase, N-terminal domain Methyltransf_31 PF13847.6 CRG87892.1 - 0.12 12.1 0.0 0.38 10.5 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain MFS_1 PF07690.16 CRG87893.1 - 2.1e-36 125.6 51.6 8e-36 123.7 50.7 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG87893.1 - 1e-11 44.0 19.0 1.4e-11 43.6 19.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AgrB PF04647.15 CRG87893.1 - 6.5 6.0 10.1 0.079 12.3 0.5 2.6 3 1 0 3 3 3 0 Accessory gene regulator B Carn_acyltransf PF00755.20 CRG87895.1 - 2e-122 409.8 0.1 3.1e-122 409.2 0.1 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase N-SET PF11764.8 CRG87895.1 - 1e-52 178.7 0.0 2.7e-52 177.4 0.0 1.8 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 CRG87895.1 - 2.4e-26 91.2 0.4 7.7e-26 89.5 0.4 2.0 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated AMP-binding PF00501.28 CRG87895.1 - 1.3e-24 86.6 0.0 2.1e-24 85.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme SET PF00856.28 CRG87895.1 - 2.3e-21 76.9 0.4 1.8e-20 74.0 0.2 2.7 2 0 0 2 2 2 1 SET domain PP-binding PF00550.25 CRG87895.1 - 4.9e-07 30.0 0.1 1.2e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site GP63 PF17471.2 CRG87895.1 - 0.032 14.4 0.0 0.16 12.2 0.0 2.3 1 0 0 1 1 1 0 Gene product 63 Trm112p PF03966.16 CRG87896.1 - 6.8e-15 55.4 0.1 9e-15 55.0 0.1 1.2 1 0 0 1 1 1 1 Trm112p-like protein HypA PF01155.19 CRG87896.1 - 0.021 14.8 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rad60-SLD PF11976.8 CRG87897.1 - 2.8e-18 65.5 0.1 9.9e-17 60.5 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 CRG87897.1 - 0.00025 20.7 0.0 0.00051 19.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family TMEM171 PF15471.6 CRG87897.1 - 3 6.8 4.3 4.4 6.2 4.3 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 IF-2B PF01008.17 CRG87898.1 - 2.6e-73 246.7 0.2 3.1e-73 246.4 0.2 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family LSM PF01423.22 CRG87898.1 - 2.6e-15 55.8 0.1 5.3e-15 54.9 0.1 1.5 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CRG87898.1 - 0.0055 16.8 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 CRG87898.1 - 0.0094 16.0 0.1 0.019 15.0 0.1 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain gerPA PF10676.9 CRG87898.1 - 0.14 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Spore germination protein gerPA/gerPF SIS PF01380.22 CRG87899.1 - 8.5e-60 200.3 0.0 6e-32 110.2 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 CRG87899.1 - 5e-17 62.4 0.0 9.2e-17 61.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 CRG87899.1 - 9.3e-11 41.7 0.0 2.1e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 CRG87899.1 - 0.00052 19.0 0.0 0.00087 18.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DMRL_synthase PF00885.19 CRG87900.1 - 2.9e-56 189.2 2.7 7.4e-56 187.9 2.7 1.6 1 1 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Zn_Tnp_IS1595 PF12760.7 CRG87901.1 - 0.034 14.1 2.7 0.064 13.2 2.7 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Lar_restr_allev PF14354.6 CRG87901.1 - 0.08 13.3 0.4 0.19 12.1 0.4 1.6 1 0 0 1 1 1 0 Restriction alleviation protein Lar Elf1 PF05129.13 CRG87901.1 - 0.12 12.4 0.8 0.21 11.6 0.8 1.4 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Iso_dh PF00180.20 CRG87902.1 - 8.9e-84 281.6 0.0 1.1e-83 281.3 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase WBS_methylT PF12589.8 CRG87903.1 - 5.6e-16 59.1 2.7 9.6e-16 58.3 2.7 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 CRG87903.1 - 3e-11 43.8 0.0 5.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87903.1 - 1.1e-10 42.0 0.0 3.4e-10 40.5 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG87903.1 - 6e-05 23.7 0.0 0.00016 22.4 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87903.1 - 0.00014 21.7 0.0 0.00025 20.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG87903.1 - 0.00048 20.0 0.0 0.00083 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CRG87903.1 - 0.0013 18.5 0.0 0.0024 17.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CRG87903.1 - 0.011 15.1 0.0 0.046 13.0 0.0 2.0 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CRG87903.1 - 0.18 11.1 0.0 2.3 7.4 0.0 2.0 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Erv26 PF04148.13 CRG87904.1 - 1e-92 309.6 0.2 1.1e-92 309.4 0.2 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 DUF1970 PF09301.10 CRG87904.1 - 0.024 14.9 0.5 0.064 13.5 0.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1970) MDM31_MDM32 PF08118.11 CRG87905.1 - 2.1e-249 828.6 0.0 3.6e-249 827.8 0.0 1.4 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins RhoGAP PF00620.27 CRG87905.1 - 8.7e-40 136.0 0.0 1.9e-39 135.0 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 CRG87905.1 - 1e-14 54.9 0.0 3e-14 53.4 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 CRG87905.1 - 0.17 12.2 0.0 0.83 10.0 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain KH_8 PF17903.1 CRG87906.1 - 0.0013 18.8 0.0 0.0025 17.9 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 CRG87906.1 - 0.0071 16.2 0.4 0.017 14.9 0.4 1.6 1 0 0 1 1 1 1 KH domain Proteasome PF00227.26 CRG87907.1 - 6.2e-32 110.6 0.0 2.9e-31 108.4 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit HCNGP PF07818.13 CRG87908.1 - 5.5e-29 100.7 0.4 9.7e-29 99.9 0.4 1.4 1 0 0 1 1 1 1 HCNGP-like protein Proteasome PF00227.26 CRG87909.1 - 7.8e-29 100.5 0.0 9.2e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit FAA_hydrolase PF01557.18 CRG87910.1 - 8.2e-65 218.5 0.0 1.1e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family GspH PF12019.8 CRG87910.1 - 0.053 13.9 0.6 0.1 13.0 0.2 1.6 2 0 0 2 2 2 0 Type II transport protein GspH DUF2437 PF10370.9 CRG87910.1 - 0.12 13.3 0.1 0.59 11.1 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF2437) Autophagy_act_C PF03987.15 CRG87912.1 - 2.2e-12 47.3 0.2 5.6e-12 46.1 0.2 1.7 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain RRM_1 PF00076.22 CRG87913.1 - 5.8e-10 38.8 0.0 1.3e-09 37.7 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG87913.1 - 0.0001 21.9 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG87913.1 - 0.014 15.3 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 CRG87913.1 - 0.066 13.3 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 Limkain b1 WD40 PF00400.32 CRG87914.1 - 3e-15 56.4 10.9 0.00012 22.8 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87914.1 - 4e-07 30.3 0.0 0.0095 16.2 0.0 4.0 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 CRG87914.1 - 0.0097 15.8 0.1 0.03 14.3 0.1 1.8 1 0 0 1 1 1 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 CRG87914.1 - 0.14 11.0 0.1 18 4.2 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Lipase_3 PF01764.25 CRG87915.1 - 2.2e-29 102.1 0.0 3.2e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CRG87915.1 - 0.00012 22.8 0.0 0.00016 22.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG87915.1 - 0.00076 18.8 0.0 0.0013 18.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CRG87915.1 - 0.0092 15.7 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Lipase PF00151.19 CRG87915.1 - 0.024 13.9 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Lipase Esterase PF00756.20 CRG87915.1 - 0.06 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative esterase DUF2974 PF11187.8 CRG87915.1 - 0.17 11.4 0.0 1.1 8.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) WW PF00397.26 CRG87916.1 - 1.2e-11 44.5 0.6 2.5e-11 43.5 0.6 1.6 1 0 0 1 1 1 1 WW domain PhoD PF09423.10 CRG87916.1 - 0.0088 15.1 0.1 0.02 13.9 0.1 1.5 1 0 0 1 1 1 1 PhoD-like phosphatase Fungal_trans_2 PF11951.8 CRG87917.1 - 1.9e-20 73.0 9.1 2.3e-19 69.5 9.1 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG87917.1 - 1.8e-09 37.6 7.7 3.5e-09 36.6 7.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ecm29 PF13001.7 CRG87918.1 - 7.2e-156 519.7 0.0 2.1e-153 511.6 0.0 2.8 3 0 0 3 3 3 2 Proteasome stabiliser HEAT_EZ PF13513.6 CRG87918.1 - 0.011 16.3 4.7 13 6.4 0.0 6.2 5 1 1 6 6 6 0 HEAT-like repeat HEAT PF02985.22 CRG87918.1 - 0.013 15.7 9.2 1.9 9.0 0.0 7.5 7 0 0 7 7 7 0 HEAT repeat V_ATPase_I PF01496.19 CRG87919.1 - 0.063 11.2 1.5 0.089 10.7 1.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HIP1_clath_bdg PF16515.5 CRG87919.1 - 0.15 12.7 7.4 0.37 11.4 6.2 2.3 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RGM_C PF06534.13 CRG87919.1 - 0.17 11.4 0.4 5.4 6.5 0.0 2.2 2 0 0 2 2 2 0 Repulsive guidance molecule (RGM) C-terminus PRKG1_interact PF15898.5 CRG87919.1 - 0.21 12.5 8.0 0.97 10.4 0.1 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain adh_short_C2 PF13561.6 CRG87922.1 - 9.5e-40 136.6 1.4 2.4e-39 135.3 1.4 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87922.1 - 4.4e-33 114.4 2.9 2.3e-32 112.1 2.9 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87922.1 - 9.6e-11 41.9 2.7 3.5e-09 36.8 2.7 2.2 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG87922.1 - 0.0016 18.0 1.0 0.0034 16.9 0.0 2.0 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family Oxidored_nitro PF00148.19 CRG87922.1 - 0.0035 16.1 0.0 0.005 15.6 0.0 1.3 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase GDP_Man_Dehyd PF16363.5 CRG87922.1 - 0.084 12.2 0.4 0.32 10.3 0.0 2.0 2 1 0 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CRG87922.1 - 0.09 13.0 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 2-Hacid_dh_C PF02826.19 CRG87922.1 - 0.14 11.5 0.3 0.26 10.6 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_deac_1 PF01522.21 CRG87923.1 - 2.1e-20 72.9 0.0 5.5e-20 71.5 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 CRG87923.1 - 5.8e-06 26.1 0.0 1.1e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 CRG87923.1 - 0.048 12.0 0.0 0.063 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2194) Peroxidase_2 PF01328.17 CRG87923.1 - 0.13 12.7 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 Peroxidase, family 2 FMN_dh PF01070.18 CRG87924.1 - 5.8e-103 344.6 0.2 2.5e-102 342.5 0.2 1.9 1 1 0 1 1 1 1 FMN-dependent dehydrogenase MFS_1 PF07690.16 CRG87924.1 - 9.8e-22 77.3 30.2 1.2e-21 77.1 28.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Cyt-b5 PF00173.28 CRG87924.1 - 2.9e-18 65.8 0.0 8.7e-18 64.2 0.0 1.9 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Sugar_tr PF00083.24 CRG87924.1 - 1.1e-14 54.2 18.0 7.5e-13 48.1 4.6 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter Glu_synthase PF01645.17 CRG87924.1 - 6.3e-05 22.3 0.1 0.00012 21.4 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG87924.1 - 0.00019 20.6 0.1 0.0019 17.3 0.0 2.5 3 0 0 3 3 3 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CRG87924.1 - 0.13 11.7 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein DIOX_N PF14226.6 CRG87925.1 - 6.4e-29 101.1 0.1 2.3e-28 99.3 0.0 1.8 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG87925.1 - 7.1e-23 81.0 0.0 3.8e-22 78.7 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Fungal_trans PF04082.18 CRG87926.1 - 3.2e-36 124.7 0.9 5e-36 124.1 0.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG87926.1 - 3.8e-33 114.9 26.2 6.3e-33 114.2 26.2 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily zf-C2H2 PF00096.26 CRG87926.1 - 9.9e-06 25.7 14.1 0.00047 20.5 0.8 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG87926.1 - 5e-05 23.8 6.3 0.11 13.4 0.4 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 CRG87926.1 - 0.06 13.6 0.2 0.18 12.1 0.2 1.7 1 0 0 1 1 1 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 CRG87926.1 - 0.098 13.3 0.7 0.23 12.1 0.7 1.6 1 0 0 1 1 1 0 FOXP coiled-coil domain Oxidored_FMN PF00724.20 CRG87927.1 - 9.9e-90 301.2 0.0 1.2e-89 301.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family FAD_binding_3 PF01494.19 CRG87928.1 - 1.6e-77 261.2 0.0 2.2e-77 260.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CRG87928.1 - 6.7e-25 88.0 0.0 1.3e-24 87.1 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 CRG87928.1 - 3.2e-07 29.9 0.1 0.00011 21.6 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG87928.1 - 3.6e-06 26.8 0.0 1e-05 25.3 0.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG87928.1 - 1.3e-05 25.6 0.0 3.3e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG87928.1 - 2.9e-05 24.2 0.0 6.5e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG87928.1 - 9e-05 21.3 0.0 0.00013 20.8 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 CRG87928.1 - 0.0015 17.9 0.0 0.0032 16.8 0.0 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CRG87928.1 - 0.0017 17.7 0.0 0.0032 16.8 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 CRG87928.1 - 0.0022 17.1 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CRG87928.1 - 0.0032 16.6 0.0 0.0068 15.5 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CRG87928.1 - 0.0063 15.8 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Thi4 family 3HCDH_N PF02737.18 CRG87928.1 - 0.021 14.7 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 CRG87928.1 - 0.024 14.3 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 CRG87928.1 - 0.03 13.4 0.0 0.046 12.8 0.0 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A 2-Hacid_dh_C PF02826.19 CRG87928.1 - 0.031 13.6 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 CRG87928.1 - 0.048 14.2 0.0 0.13 12.8 0.0 1.8 1 0 0 1 1 1 0 XdhC Rossmann domain IlvN PF07991.12 CRG87928.1 - 0.065 12.8 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_9 PF13454.6 CRG87928.1 - 0.072 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CRG87928.1 - 0.098 12.2 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Trp_halogenase PF04820.14 CRG87928.1 - 0.12 11.2 0.0 0.25 10.1 0.0 1.5 1 1 0 1 1 1 0 Tryptophan halogenase PALP PF00291.25 CRG87928.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme TrkA_N PF02254.18 CRG87928.1 - 0.15 12.3 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain adh_short_C2 PF13561.6 CRG87929.1 - 7.1e-57 192.7 0.1 8.2e-57 192.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG87929.1 - 1.6e-41 141.9 0.0 2.1e-41 141.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG87929.1 - 2.8e-09 37.1 0.1 5.7e-09 36.1 0.1 1.6 1 1 0 1 1 1 1 KR domain Ring_hydroxyl_A PF00848.19 CRG87930.1 - 2.7e-22 79.8 5.1 2.6e-10 40.6 0.1 2.4 1 1 1 2 2 2 2 Ring hydroxylating alpha subunit (catalytic domain) FAD_binding_3 PF01494.19 CRG87930.1 - 2.1e-13 50.2 0.2 2.4e-10 40.2 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain Rieske PF00355.26 CRG87930.1 - 4.7e-13 48.9 0.0 8.9e-13 48.0 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain DAO PF01266.24 CRG87930.1 - 1e-07 31.9 3.1 0.0015 18.2 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CRG87930.1 - 1.9e-07 30.3 2.8 0.00055 18.9 0.1 2.2 1 1 0 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 CRG87930.1 - 1.4e-06 27.8 0.2 0.035 13.3 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG87930.1 - 3.1e-06 26.5 0.4 6.7e-06 25.4 0.4 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 CRG87930.1 - 0.00018 20.4 1.4 0.0017 17.1 1.4 2.0 1 1 0 1 1 1 1 HI0933-like protein FAD_binding_2 PF00890.24 CRG87930.1 - 0.00018 20.7 5.5 0.0015 17.7 3.7 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CRG87930.1 - 0.007 16.9 0.2 3.4 8.3 0.4 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CRG87930.1 - 0.033 14.1 0.3 0.059 13.2 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 CRG87930.1 - 0.034 14.4 2.1 0.063 13.5 1.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CRG87930.1 - 0.078 12.3 0.7 0.38 10.1 1.0 1.9 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG87930.1 - 0.17 11.1 0.1 1.1 8.5 0.6 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CRG87930.1 - 0.17 10.9 0.0 0.46 9.5 0.0 1.6 2 0 0 2 2 2 0 Squalene epoxidase GIDA PF01134.22 CRG87930.1 - 1 8.3 3.3 2 7.4 3.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Arylsulfotrans PF05935.11 CRG87931.1 - 4.4e-20 71.9 0.0 7.3e-20 71.2 0.0 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotran_2 PF14269.6 CRG87931.1 - 5.2e-19 68.7 0.0 1e-18 67.8 0.0 1.4 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) PQQ_2 PF13360.6 CRG87931.1 - 9.4e-05 22.1 0.1 0.0025 17.4 0.0 2.6 1 1 1 2 2 2 2 PQQ-like domain PDZ_6 PF17820.1 CRG87931.1 - 0.071 13.0 0.1 3.4 7.6 0.0 2.7 2 0 0 2 2 2 0 PDZ domain Alpha-amylase PF00128.24 CRG87932.1 - 5.8e-59 200.3 1.7 5.2e-58 197.2 1.7 2.0 1 1 0 1 1 1 1 Alpha amylase, catalytic domain Aa_trans PF01490.18 CRG87932.1 - 9.3e-26 90.5 27.8 1.2e-25 90.1 27.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF1966 PF09260.11 CRG87932.1 - 0.00015 22.0 0.0 0.00032 20.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) hDGE_amylase PF14701.6 CRG87932.1 - 0.15 11.1 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Cutinase PF01083.22 CRG87933.1 - 1e-51 175.4 8.3 1.2e-51 175.2 8.3 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CRG87933.1 - 8.1e-06 25.5 0.8 1.9e-05 24.3 0.8 1.6 1 1 0 1 1 1 1 PE-PPE domain Abhydrolase_6 PF12697.7 CRG87933.1 - 0.0028 18.3 0.1 0.0037 17.9 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG87933.1 - 0.013 15.2 0.3 0.02 14.6 0.3 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG87933.1 - 0.081 12.2 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF3089 PF11288.8 CRG87933.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) VWA_2 PF13519.6 CRG87933.1 - 0.14 12.8 0.1 0.3 11.7 0.1 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF676 PF05057.14 CRG87933.1 - 0.15 11.6 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) LMBR1 PF04791.16 CRG87933.1 - 0.25 10.2 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Abhydrolase_1 PF00561.20 CRG87934.1 - 2.1e-13 50.5 0.1 3.2e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG87934.1 - 7.1e-08 33.3 0.8 9.2e-08 32.9 0.8 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG87934.1 - 1.8e-05 24.2 0.0 2.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Tannase PF07519.11 CRG87935.1 - 1.1e-99 334.5 0.1 1.3e-99 334.3 0.1 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 CRG87935.1 - 0.00047 19.7 0.0 0.0024 17.4 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CRG87935.1 - 0.0071 15.6 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 SNF2_N PF00176.23 CRG87936.1 - 1.1e-55 188.8 0.1 2.9e-55 187.4 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 CRG87936.1 - 3.6e-08 33.1 9.3 9.5e-08 31.8 9.3 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG87936.1 - 1.1e-07 31.5 7.7 3.3e-07 30.1 7.7 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG87936.1 - 2.2e-07 30.7 8.7 5.4e-07 29.4 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG87936.1 - 1e-06 29.0 10.6 2.1e-06 27.9 10.6 1.6 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 CRG87936.1 - 1.2e-06 28.2 7.0 3e-06 27.0 7.0 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Helicase_C PF00271.31 CRG87936.1 - 6.4e-06 26.5 0.0 1.4e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 CRG87936.1 - 3.5e-05 23.7 5.7 7.5e-05 22.7 5.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 CRG87936.1 - 0.00091 19.5 7.6 0.0026 18.0 7.6 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 CRG87936.1 - 0.0013 18.6 9.0 0.0032 17.4 9.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain RPA_interact_M PF14767.6 CRG87936.1 - 0.026 15.1 0.1 0.14 12.8 0.1 2.3 1 1 0 1 1 1 0 Replication protein A interacting middle zf-C3HC4_4 PF15227.6 CRG87936.1 - 0.068 13.3 8.7 0.15 12.3 8.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 CRG87936.1 - 0.18 11.7 1.7 0.21 11.5 0.3 1.9 2 0 0 2 2 1 0 Baculovirus immediate-early protein (IE-0) FadA PF09403.10 CRG87936.1 - 0.62 10.6 8.8 8.3 7.0 0.3 3.1 2 0 0 2 2 2 0 Adhesion protein FadA zf-RING_4 PF14570.6 CRG87936.1 - 0.75 9.6 6.3 2.6 7.9 6.3 1.9 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 CRG87936.1 - 2 8.1 8.6 4.3 7.0 8.6 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DZR PF12773.7 CRG87936.1 - 5 7.2 7.7 2.7 8.1 3.8 2.3 2 0 0 2 2 2 0 Double zinc ribbon PNGaseA PF12222.8 CRG87937.1 - 3e-185 616.2 0.0 3.8e-185 615.9 0.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A PMM PF03332.13 CRG87939.1 - 2.4e-99 331.6 0.0 3.3e-99 331.1 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase DnaJ PF00226.31 CRG87939.1 - 4.5e-19 68.3 0.8 9.2e-19 67.3 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain S6PP PF05116.13 CRG87939.1 - 0.00018 21.1 0.0 0.38 10.3 0.0 2.2 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 CRG87939.1 - 0.042 13.6 0.0 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Bacteriocin_IIc PF10439.9 CRG87939.1 - 0.14 12.3 5.1 0.25 11.5 5.1 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide DUF456 PF04306.13 CRG87939.1 - 0.15 12.3 1.5 0.25 11.6 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Gly-zipper_Omp PF13488.6 CRG87939.1 - 0.58 10.2 10.6 1.3 9.1 10.6 1.5 1 0 0 1 1 1 0 Glycine zipper DUF1640 PF07798.11 CRG87940.1 - 8.6e-55 185.5 8.6 1.1e-54 185.1 8.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) DnaJ PF00226.31 CRG87941.1 - 2.1e-10 40.5 1.3 1.3e-09 38.1 0.3 2.3 2 0 0 2 2 2 1 DnaJ domain PRA1 PF03208.19 CRG87942.1 - 3.8e-31 107.6 1.5 5.5e-31 107.1 1.5 1.2 1 0 0 1 1 1 1 PRA1 family protein CW_7 PF08230.11 CRG87942.1 - 0.0051 16.5 1.6 0.55 10.0 0.9 2.5 2 0 0 2 2 2 2 CW_7 repeat YL1 PF05764.13 CRG87942.1 - 1.7 8.7 39.0 0.54 10.3 10.0 2.3 2 0 0 2 2 2 0 YL1 nuclear protein TLP-20 PF06088.11 CRG87942.1 - 2.7 7.9 8.3 0.2 11.6 2.4 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DNA_pol_phi PF04931.13 CRG87942.1 - 5.1 5.1 21.3 8.3 4.4 21.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 CRG87942.1 - 9.9 6.2 18.0 0.67 10.0 9.0 2.8 2 0 0 2 2 2 0 RXT2-like, N-terminal Frag1 PF10277.9 CRG87943.1 - 1.4e-46 158.8 12.5 1.9e-46 158.4 12.5 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Y_phosphatase3 PF13350.6 CRG87943.1 - 1.6e-42 146.1 0.0 2.3e-42 145.6 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 CRG87943.1 - 0.00026 20.6 0.0 0.00046 19.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 CRG87943.1 - 0.069 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Myotub-related PF06602.14 CRG87943.1 - 0.27 10.1 0.0 0.47 9.3 0.0 1.3 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Glyco_hydro_35 PF01301.19 CRG87944.1 - 1.1e-82 278.3 3.2 2.1e-82 277.2 3.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 CRG87944.1 - 8.1e-55 185.4 2.1 8.1e-55 185.4 2.1 1.8 2 0 0 2 2 2 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 CRG87944.1 - 2.9e-54 182.5 2.0 2.9e-30 105.2 0.0 3.0 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 CRG87944.1 - 2.5e-21 75.0 0.2 1.2e-20 72.9 0.0 2.2 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 Cellulase PF00150.18 CRG87944.1 - 5.3e-05 22.8 0.6 0.00064 19.2 0.3 2.5 3 1 0 3 3 3 1 Cellulase (glycosyl hydrolase family 5) FA_hydroxylase PF04116.13 CRG87945.1 - 6.9e-26 91.2 12.4 6.9e-26 91.2 12.4 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Fungal_trans PF04082.18 CRG87946.1 - 7.9e-12 44.8 0.3 1.3e-11 44.1 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG87947.1 - 3.7e-44 151.1 54.8 8.1e-44 150.0 54.1 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG87947.1 - 1.3e-17 63.5 21.3 1.6e-17 63.2 21.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG87947.1 - 2.1e-12 46.7 14.1 2.1e-12 46.7 14.1 2.9 1 1 2 3 3 3 1 Sugar (and other) transporter MFS_3 PF05977.13 CRG87947.1 - 0.00078 18.0 3.2 0.00078 18.0 3.2 2.2 2 0 0 2 2 2 1 Transmembrane secretion effector OATP PF03137.20 CRG87947.1 - 0.73 8.0 24.3 0.019 13.3 0.7 3.4 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family AMP-binding PF00501.28 CRG87948.1 - 2.1e-143 478.0 0.0 2.4e-77 260.4 0.0 2.5 2 1 0 2 2 2 2 AMP-binding enzyme Condensation PF00668.20 CRG87948.1 - 2.1e-73 247.6 0.0 2.7e-36 125.3 0.0 2.6 2 1 0 2 2 2 2 Condensation domain AMP-binding_C PF13193.6 CRG87948.1 - 7.8e-09 36.4 0.0 0.011 16.7 0.0 2.9 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 CRG87948.1 - 8.3e-09 35.7 0.2 0.0053 17.1 0.1 2.6 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_2 PF00891.18 CRG87949.1 - 4.6e-24 84.9 0.0 7.5e-24 84.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CRG87949.1 - 0.00066 20.3 0.0 0.0014 19.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Dimerisation2 PF16864.5 CRG87949.1 - 0.001 19.0 0.4 0.0062 16.5 0.0 2.4 3 0 0 3 3 3 1 Dimerisation domain MarR PF01047.22 CRG87949.1 - 0.014 15.3 0.0 0.031 14.2 0.0 1.6 1 0 0 1 1 1 0 MarR family Methyltransf_31 PF13847.6 CRG87949.1 - 0.17 11.7 0.1 0.32 10.8 0.1 1.5 1 0 0 1 1 1 0 Methyltransferase domain 4HBT_2 PF13279.6 CRG87950.1 - 3.5e-09 37.2 0.0 5.3e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily API5 PF05918.11 CRG87951.1 - 0.025 13.4 0.1 0.034 13.0 0.1 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) p450 PF00067.22 CRG87952.1 - 5.5e-28 97.9 1.1 2.1e-21 76.2 0.1 2.1 1 1 1 2 2 2 2 Cytochrome P450 FAD_binding_1 PF00667.20 CRG87952.1 - 0.051 13.1 0.1 1.8 8.1 0.1 2.1 2 0 0 2 2 2 0 FAD binding domain Abhydrolase_6 PF12697.7 CRG87953.1 - 2.3e-08 34.9 0.1 2.8e-08 34.6 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG87953.1 - 0.0011 18.6 0.1 0.0017 18.1 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold GST_N_3 PF13417.6 CRG87953.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Aminotran_4 PF01063.19 CRG87954.1 - 5.5e-26 91.8 0.0 7.3e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV p450 PF00067.22 CRG87955.1 - 4.9e-52 177.2 0.0 6.2e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ketoacyl-synt PF00109.26 CRG87956.1 - 3.6e-61 206.9 0.0 8.7e-61 205.7 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG87956.1 - 2.3e-59 201.1 0.0 3.5e-59 200.5 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CRG87956.1 - 3.3e-59 199.8 0.3 7e-59 198.8 0.3 1.6 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CRG87956.1 - 3.1e-52 178.1 0.0 5.2e-52 177.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG87956.1 - 5.3e-35 120.0 0.3 1.1e-34 119.0 0.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG87956.1 - 9.4e-20 72.0 0.0 9.5e-19 68.8 0.0 2.8 3 0 0 3 3 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 CRG87956.1 - 1.2e-18 67.6 0.2 3.3e-18 66.2 0.0 2.0 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 CRG87956.1 - 4.2e-18 65.9 0.0 4.2e-17 62.7 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain ADH_zinc_N PF00107.26 CRG87956.1 - 1.6e-13 50.8 0.0 7.3e-13 48.6 0.0 2.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 CRG87956.1 - 1.1e-10 41.6 0.0 3.5e-10 39.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG87956.1 - 4.6e-09 36.9 0.0 1.1e-07 32.4 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 CRG87956.1 - 2.9e-08 33.4 0.3 1.7e-07 30.9 0.1 2.2 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CRG87956.1 - 4.3e-08 33.4 0.1 1.1e-07 32.0 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_N PF08240.12 CRG87956.1 - 2.3e-07 30.7 0.5 7.4e-06 25.8 0.3 2.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Methyltransf_11 PF08241.12 CRG87956.1 - 4.3e-06 27.3 0.0 1.4e-05 25.7 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG87956.1 - 5.7e-06 26.2 0.0 1.4e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CRG87956.1 - 2.3e-05 24.1 0.0 5.5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 CRG87956.1 - 0.016 14.6 0.1 0.039 13.3 0.1 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CRG87956.1 - 0.016 15.0 1.1 0.042 13.7 1.1 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Beta-lactamase PF00144.24 CRG87958.1 - 6.5e-40 137.4 0.0 9e-40 136.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CRG87958.1 - 2.5e-10 40.7 0.1 4e-10 40.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) NB-ARC PF00931.22 CRG87959.1 - 4.8e-11 42.3 0.0 9.3e-11 41.4 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain TPR_12 PF13424.6 CRG87959.1 - 8.6e-11 42.0 0.4 0.00046 20.4 0.0 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat AAA_22 PF13401.6 CRG87959.1 - 1.5e-07 31.7 0.0 5.8e-07 29.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain TPR_10 PF13374.6 CRG87959.1 - 7e-07 28.9 0.0 4.1 7.4 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 CRG87959.1 - 0.00025 21.0 2.5 0.75 10.2 0.1 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG87959.1 - 0.00028 20.8 1.8 0.53 10.5 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat NACHT PF05729.12 CRG87959.1 - 0.0022 17.9 0.3 0.0082 16.1 0.0 2.2 2 0 0 2 2 2 1 NACHT domain TPR_14 PF13428.6 CRG87959.1 - 0.0056 17.4 0.5 47 5.2 0.0 4.7 4 0 0 4 4 3 0 Tetratricopeptide repeat AAA_16 PF13191.6 CRG87959.1 - 0.017 15.5 0.3 0.099 13.0 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain DUF3907 PF13047.6 CRG87959.1 - 0.043 13.8 0.2 4.1 7.4 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3907) DUF2075 PF09848.9 CRG87959.1 - 0.061 12.6 0.0 0.57 9.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TPR_7 PF13176.6 CRG87959.1 - 0.067 13.3 0.0 48 4.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CRG87959.1 - 0.08 13.5 6.3 36 5.0 0.0 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat IstB_IS21 PF01695.17 CRG87959.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Eisosome1 PF12757.7 CRG87960.1 - 5.2e-35 120.4 6.7 5.2e-35 120.4 6.7 3.3 4 0 0 4 4 4 1 Eisosome protein 1 MFS_1 PF07690.16 CRG87960.1 - 5e-31 107.9 25.3 5e-31 107.9 25.3 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG87960.1 - 4e-09 35.8 11.2 4e-09 35.8 11.2 3.3 3 0 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 CRG87960.1 - 0.042 12.3 5.1 0.077 11.4 5.1 1.3 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_1 PF05106.12 CRG87960.1 - 7.4 7.1 6.7 14 6.2 0.1 3.2 2 1 1 3 3 3 0 Phage holin family (Lysis protein S) CFEM PF05730.11 CRG87961.1 - 2.2e-13 50.1 15.2 5.3e-13 48.9 15.2 1.7 1 0 0 1 1 1 1 CFEM domain NUDE_C PF04880.13 CRG87961.1 - 3.4 8.1 6.4 5 7.6 6.4 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region Prenyltrans PF00432.21 CRG87962.1 - 1e-25 89.1 10.2 0.00013 21.6 0.0 6.3 6 1 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 CRG87962.1 - 0.072 12.2 0.0 0.46 9.5 0.0 2.0 1 1 0 1 1 1 0 Squalene-hopene cyclase C-terminal domain Pkinase PF00069.25 CRG87963.1 - 1.5e-68 231.0 0.0 2.3e-68 230.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG87963.1 - 6.2e-44 150.2 0.0 9.1e-44 149.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG87963.1 - 1.9e-07 30.7 0.0 1.4e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CRG87963.1 - 2.2e-06 26.9 0.1 2.2e-06 26.9 0.1 1.9 2 1 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CRG87963.1 - 0.052 13.5 2.5 0.64 9.9 0.1 2.7 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 CRG87963.1 - 0.054 12.8 0.0 0.14 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ferlin_C PF16165.5 CRG87963.1 - 0.13 12.2 0.4 0.28 11.1 0.4 1.5 1 0 0 1 1 1 0 Ferlin C-terminus E1-E2_ATPase PF00122.20 CRG87964.1 - 4.7e-52 176.1 3.0 4.7e-52 176.1 3.0 2.6 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 CRG87964.1 - 5.3e-46 156.6 5.4 5.3e-46 156.6 5.4 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 CRG87964.1 - 1.2e-22 81.3 0.1 4.5e-22 79.4 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 CRG87964.1 - 1.5e-16 60.2 0.0 3.2e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 CRG87964.1 - 2e-16 59.4 0.2 8.4e-16 57.4 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CRG87964.1 - 1.5e-07 31.4 0.8 3.9e-06 26.8 0.9 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CRG87964.1 - 5.4e-05 23.7 0.0 0.00019 21.9 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GHL6 PF14871.6 CRG87964.1 - 0.095 12.8 0.1 3.8 7.7 0.0 2.8 3 0 0 3 3 3 0 Hypothetical glycosyl hydrolase 6 Fumarate_red_D PF02313.17 CRG87964.1 - 0.75 9.9 0.0 0.75 9.9 0.0 3.0 3 0 0 3 3 3 0 Fumarate reductase subunit D 14-3-3 PF00244.20 CRG87965.1 - 1.3e-107 358.4 2.9 1.6e-107 358.1 2.9 1.1 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 CRG87965.1 - 0.012 14.0 1.1 0.02 13.3 1.1 1.3 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 tRNA-synt_1c PF00749.21 CRG87966.1 - 2.4e-92 309.2 0.0 3.8e-92 308.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CRG87966.1 - 7e-31 107.4 0.0 1.1e-30 106.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Enolase_C PF00113.22 CRG87967.1 - 5e-152 505.3 0.0 7.3e-152 504.7 0.0 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain eIF3_subunit PF08597.10 CRG87967.1 - 1.5e-71 241.1 34.0 2.2e-71 240.6 34.0 1.3 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Enolase_N PF03952.16 CRG87967.1 - 2.5e-57 192.7 0.2 2.5e-57 192.7 0.2 2.1 2 0 0 2 2 2 1 Enolase, N-terminal domain Nucleo_P87 PF07267.11 CRG87967.1 - 6.9 5.4 13.2 15 4.3 13.2 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AAA PF00004.29 CRG87968.1 - 6.1e-43 146.4 0.0 1.2e-42 145.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CRG87968.1 - 5.8e-12 45.4 0.2 8.4e-11 41.7 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CRG87968.1 - 8.4e-11 41.5 0.1 1.6e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 CRG87968.1 - 1.6e-07 31.9 0.0 6e-05 23.5 0.0 2.7 2 1 1 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 CRG87968.1 - 1.6e-06 28.2 0.1 3.8e-05 23.7 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CRG87968.1 - 3.5e-06 27.3 0.0 9.3e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 CRG87968.1 - 6.9e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CRG87968.1 - 0.00022 21.5 0.1 0.0061 16.8 0.0 2.4 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 CRG87968.1 - 0.00038 19.7 0.0 0.00081 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 CRG87968.1 - 0.00045 20.8 0.1 0.0026 18.3 0.0 2.3 3 1 0 3 3 2 1 AAA domain AAA_7 PF12775.7 CRG87968.1 - 0.0009 18.8 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 CRG87968.1 - 0.0018 17.6 0.0 0.0042 16.3 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 CRG87968.1 - 0.0025 17.8 0.0 0.0089 16.0 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 CRG87968.1 - 0.0033 17.6 0.0 0.01 16.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain Mg_chelatase PF01078.21 CRG87968.1 - 0.0045 16.4 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Prot_ATP_OB_N PF17758.1 CRG87968.1 - 0.0047 16.5 0.0 0.014 15.0 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain RNA_helicase PF00910.22 CRG87968.1 - 0.0059 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 CRG87968.1 - 0.0061 16.3 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 CRG87968.1 - 0.0071 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CRG87968.1 - 0.0085 15.8 0.0 0.031 14.0 0.0 1.9 1 1 1 2 2 2 1 Sigma-54 interaction domain AAA_24 PF13479.6 CRG87968.1 - 0.012 15.4 0.1 0.058 13.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CRG87968.1 - 0.014 15.3 0.0 0.03 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 CRG87968.1 - 0.033 13.9 0.1 3.8 7.1 0.0 2.6 3 0 0 3 3 2 0 Thymidylate kinase ATPase PF06745.13 CRG87968.1 - 0.046 13.1 1.3 0.15 11.4 0.0 2.3 3 0 0 3 3 3 0 KaiC AAA_30 PF13604.6 CRG87968.1 - 0.049 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CRG87968.1 - 0.058 13.3 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain PhoH PF02562.16 CRG87968.1 - 0.059 12.8 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 CRG87968.1 - 0.065 13.0 0.1 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CRG87968.1 - 0.086 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CRG87968.1 - 0.092 12.6 0.1 0.37 10.7 0.0 2.1 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_28 PF13521.6 CRG87968.1 - 0.094 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CRG87968.1 - 0.12 11.6 0.0 0.25 10.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 CRG87968.1 - 0.12 11.4 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 IR1-M PF12185.8 CRG87968.1 - 0.16 12.0 0.2 0.53 10.3 0.2 1.9 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain DUF16 PF01519.16 CRG87968.1 - 0.23 11.9 1.2 0.62 10.6 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF16 Glyco_hydro_47 PF01532.20 CRG87969.1 - 7.2e-165 549.3 0.1 8.5e-165 549.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 M20_dimer PF07687.14 CRG87970.1 - 3.7e-19 68.7 0.0 6e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 CRG87970.1 - 5.7e-16 58.8 0.0 1.5e-14 54.2 0.0 2.3 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 CRG87970.1 - 0.032 13.9 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M28 HATPase_c PF02518.26 CRG87971.1 - 8e-20 71.4 0.0 1.7e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG87971.1 - 1.3e-16 60.7 0.7 0.00013 22.1 0.0 3.5 3 0 0 3 3 3 3 Response regulator receiver domain HisKA PF00512.25 CRG87971.1 - 8.7e-05 22.5 0.0 0.00022 21.2 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain APH PF01636.23 CRG87972.1 - 3.5e-05 23.8 0.0 4.3e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family EHN PF06441.12 CRG87973.1 - 3e-30 104.8 3.2 3.5e-29 101.3 0.0 2.6 3 0 0 3 3 3 2 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG87973.1 - 6.8e-19 68.5 0.1 6.4e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Proteasome PF00227.26 CRG87974.1 - 1.5e-40 138.8 0.0 1.7e-40 138.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit TUG-UBL1 PF11470.8 CRG87975.1 - 7e-25 87.0 1.3 1.1e-24 86.4 0.1 2.0 2 0 0 2 2 2 1 TUG ubiquitin-like domain UBX PF00789.20 CRG87975.1 - 0.004 17.3 0.0 0.029 14.6 0.0 2.6 3 1 0 3 3 3 1 UBX domain RBD PF02196.15 CRG87975.1 - 0.066 13.3 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Raf-like Ras-binding domain Ribosomal_L36e PF01158.18 CRG87976.1 - 3e-34 117.1 10.3 1.9e-32 111.4 7.6 2.2 2 0 0 2 2 2 2 Ribosomal protein L36e PBS_linker_poly PF00427.21 CRG87976.1 - 0.0076 16.3 0.3 0.0099 15.9 0.3 1.1 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide MRP-L28 PF09812.9 CRG87976.1 - 0.097 12.8 2.3 0.12 12.5 2.3 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L28 RICTOR_N PF14664.6 CRG87976.1 - 0.17 10.9 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term NatB_MDM20 PF09797.9 CRG87977.1 - 2.6e-99 332.8 6.4 3.6e-99 332.3 6.4 1.2 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 CRG87977.1 - 0.00036 21.0 1.4 0.0019 18.7 0.1 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat CHCH PF06747.13 CRG87979.1 - 2.9e-05 24.1 6.1 5e-05 23.3 6.1 1.4 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 CRG87979.1 - 0.0056 16.9 1.3 0.0078 16.4 1.3 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type GCK PF07802.11 CRG87979.1 - 0.03 14.8 3.9 0.32 11.5 0.5 2.1 1 1 1 2 2 2 0 GCK domain Pet191_N PF10203.9 CRG87979.1 - 0.044 14.1 5.1 0.1 12.9 4.7 1.7 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 UPF0203 PF05254.12 CRG87979.1 - 0.069 13.4 5.0 0.11 12.8 5.0 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0203) COX17 PF05051.13 CRG87979.1 - 0.3 11.5 4.7 1.8 9.0 2.5 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF4429 PF14472.6 CRG87980.1 - 0.028 15.0 0.0 0.11 13.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4429) ECM1 PF05782.11 CRG87980.1 - 0.1 11.6 3.4 0.12 11.2 3.4 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) zf-C3HC4 PF00097.25 CRG87981.1 - 1.3e-08 34.5 5.0 1.3e-08 34.5 5.0 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG87981.1 - 2.7e-08 34.0 6.9 2.7e-08 34.0 6.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG87981.1 - 2.5e-07 30.4 6.6 2.5e-07 30.4 6.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG87981.1 - 4.3e-07 29.7 4.3 4.3e-07 29.7 4.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 CRG87981.1 - 5.9e-07 29.5 7.6 5.9e-07 29.5 7.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 CRG87981.1 - 5.9e-06 26.2 6.3 5.9e-06 26.2 6.3 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 CRG87981.1 - 1.6e-05 24.8 6.5 1.6e-05 24.8 6.5 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG87981.1 - 0.0011 18.8 4.9 0.0011 18.8 4.9 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 DZR PF12773.7 CRG87981.1 - 0.0028 17.6 12.3 0.047 13.7 0.5 2.8 2 1 0 2 2 2 2 Double zinc ribbon zf-RING_6 PF14835.6 CRG87981.1 - 0.0068 16.3 2.7 0.0068 16.3 2.7 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 CRG87981.1 - 0.0088 16.1 1.5 0.0088 16.1 1.5 2.0 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Baculo_IE-1 PF05290.11 CRG87981.1 - 0.083 12.8 1.2 0.14 12.1 1.2 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 CRG87981.1 - 0.17 12.1 2.8 0.35 11.0 2.8 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-Nse PF11789.8 CRG87981.1 - 0.21 11.4 1.0 0.66 9.8 1.0 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 CRG87981.1 - 0.49 10.7 13.4 0.051 13.9 7.0 2.6 2 1 0 2 2 2 0 RING-H2 zinc finger domain BUD22 PF09073.10 CRG87981.1 - 0.74 9.1 28.2 0.21 10.9 15.3 2.2 2 0 0 2 2 2 0 BUD22 HypA PF01155.19 CRG87981.1 - 1.5 8.9 5.8 4.2 7.4 0.0 2.5 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_4 PF14570.6 CRG87981.1 - 7.3 6.5 13.5 0.11 12.3 2.8 2.8 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain IBR PF01485.21 CRG87981.1 - 9 6.6 12.4 46 4.3 7.7 2.7 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain WD40 PF00400.32 CRG87982.1 - 5.8e-20 71.2 9.9 7.7e-07 29.7 0.0 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87982.1 - 0.0013 19.0 0.0 0.087 13.1 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CRG87982.1 - 0.17 11.2 0.0 0.39 10.0 0.0 1.5 1 1 0 1 1 1 0 WD40-like domain Proteasome PF00227.26 CRG87983.1 - 9.4e-32 110.0 0.0 1.9e-30 105.8 0.0 2.0 1 1 0 1 1 1 1 Proteasome subunit Sigma54_AID PF00309.20 CRG87983.1 - 0.018 14.9 0.5 0.031 14.1 0.5 1.4 1 0 0 1 1 1 0 Sigma-54 factor, Activator interacting domain (AID) UCH PF00443.29 CRG87984.1 - 1.7e-24 86.7 0.2 7.9e-24 84.5 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 CRG87984.1 - 6.9e-12 45.5 0.8 1.3e-11 44.6 0.3 1.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 CRG87984.1 - 0.001 18.7 0.0 0.015 14.9 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-C2H2_2 PF12756.7 CRG87984.1 - 0.27 11.6 0.7 3.8 7.9 0.1 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) P2_Phage_GpR PF06891.11 CRG87985.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 P2 phage tail completion protein R (GpR) DUF1518 PF07469.12 CRG87985.1 - 0.13 12.7 1.2 0.51 10.8 1.2 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1518) WD40 PF00400.32 CRG87986.1 - 1.1e-49 165.3 20.8 1.2e-05 25.9 0.2 13.6 13 3 0 13 13 13 8 WD domain, G-beta repeat Utp13 PF08625.11 CRG87986.1 - 2.8e-47 160.2 0.2 4.4e-47 159.5 0.2 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 CRG87986.1 - 5.1e-12 45.9 4.1 0.14 12.4 0.0 7.2 6 2 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG87986.1 - 0.00038 19.5 1.6 0.009 15.0 0.1 3.5 5 0 0 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CRG87986.1 - 0.016 13.9 4.8 0.41 9.3 0.1 4.2 4 1 0 4 4 4 0 Nup133 N terminal like WD40_like PF17005.5 CRG87986.1 - 0.043 13.1 0.0 5.7 6.2 0.0 3.0 3 1 0 3 3 3 0 WD40-like domain EMP70 PF02990.16 CRG87986.1 - 0.2 10.3 0.0 0.3 9.7 0.0 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 G-patch_2 PF12656.7 CRG87987.1 - 3.7e-24 84.6 0.2 1.2e-23 83.0 0.2 1.9 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 CRG87987.1 - 0.00062 19.6 1.0 0.0016 18.3 1.0 1.7 1 0 0 1 1 1 1 G-patch domain Myb_DNA-bind_6 PF13921.6 CRG87988.1 - 8.9e-18 64.3 0.5 3.1e-17 62.5 0.5 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain HSA PF07529.13 CRG87988.1 - 6.7e-14 52.0 0.2 6.7e-14 52.0 0.2 3.9 3 0 0 3 3 3 1 HSA Myb_DNA-binding PF00249.31 CRG87988.1 - 0.00026 21.1 2.7 0.00061 19.9 0.3 2.8 3 0 0 3 3 3 1 Myb-like DNA-binding domain WD40 PF00400.32 CRG87989.1 - 4.7e-10 39.9 0.2 0.18 12.7 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG87989.1 - 0.0006 20.1 0.0 18 5.7 0.0 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 CRG87989.1 - 0.032 12.4 0.0 0.12 10.5 0.0 1.7 2 0 0 2 2 2 0 CRT10 BBS2_C PF14782.6 CRG87989.1 - 0.045 12.5 0.0 7.5 5.2 0.0 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal eIF2_C PF09173.11 CRG87990.1 - 2e-34 117.7 0.5 4.1e-34 116.7 0.5 1.6 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 CRG87990.1 - 1e-23 83.9 0.2 5.4e-23 81.5 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CRG87990.1 - 8.5e-12 45.3 0.2 1.9e-11 44.2 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CRG87990.1 - 0.0014 18.7 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG87990.1 - 0.014 15.3 0.0 0.1 12.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase G-alpha PF00503.20 CRG87990.1 - 0.13 11.4 0.1 0.64 9.1 0.0 1.8 2 0 0 2 2 2 0 G-protein alpha subunit Peptidase_M48_N PF16491.5 CRG87993.1 - 1.2e-65 220.9 9.6 1.2e-65 220.9 9.6 1.7 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 CRG87993.1 - 3.5e-44 150.9 0.0 5.7e-44 150.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 CRG87993.1 - 0.0067 15.7 0.5 0.015 14.5 0.5 1.6 1 1 0 1 1 1 1 BlaR1 peptidase M56 DUF4538 PF15061.6 CRG87993.1 - 0.049 13.4 1.4 0.11 12.2 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) Peptidase_M16_C PF05193.21 CRG87994.1 - 2.5e-16 60.2 0.0 4.5e-15 56.1 0.0 2.4 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CRG87994.1 - 3.7e-06 27.0 0.2 9.3e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) ABC_sub_bind PF04392.12 CRG87994.1 - 0.024 13.9 0.1 0.046 13.0 0.1 1.4 1 0 0 1 1 1 0 ABC transporter substrate binding protein Dsl1_C PF11989.8 CRG87995.1 - 5.1e-09 36.1 0.1 1.4e-08 34.7 0.1 1.8 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal Zw10 PF06248.13 CRG87995.1 - 0.00061 18.5 1.7 0.002 16.8 1.5 1.9 1 1 0 1 1 1 1 Centromere/kinetochore Zw10 WD40 PF00400.32 CRG87996.1 - 4.9e-18 65.2 16.8 2.9e-06 27.9 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat NLE PF08154.12 CRG87996.1 - 4e-13 49.7 0.1 8.3e-13 48.7 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 CRG87996.1 - 1.9e-06 26.8 2.5 0.0021 16.8 0.8 3.1 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Ribosomal_S13 PF00416.22 CRG87997.1 - 2.2e-19 70.1 0.1 4.4e-17 62.7 0.1 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 INSIG PF07281.12 CRG87999.1 - 3.9e-71 239.1 1.2 5.3e-71 238.6 1.2 1.2 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) AICARFT_IMPCHas PF01808.18 CRG88000.1 - 1.8e-91 306.7 0.0 3e-91 306.0 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 CRG88000.1 - 1.1e-25 89.6 0.0 2.7e-25 88.4 0.0 1.7 2 0 0 2 2 2 1 MGS-like domain Anoctamin PF04547.12 CRG88001.1 - 5.6e-104 348.5 8.3 7.3e-104 348.1 8.3 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel TFIIA PF03153.13 CRG88001.1 - 0.1 12.5 5.7 0.16 11.9 5.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pex14_N PF04695.13 CRG88001.1 - 0.8 10.3 15.1 2.4 8.8 15.1 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Clathrin PF00637.20 CRG88002.1 - 9.3e-198 648.0 46.9 1.8e-32 112.2 0.3 7.8 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 CRG88002.1 - 3.4e-36 121.8 0.8 8.1e-07 29.1 0.0 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 CRG88002.1 - 2e-32 110.9 4.3 2.2e-32 110.8 0.9 3.0 2 1 1 3 3 3 1 Clathrin-H-link TPR_8 PF13181.6 CRG88002.1 - 0.0013 18.7 5.6 0.38 11.1 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88002.1 - 0.0028 17.6 4.2 37 4.6 0.1 6.4 6 0 0 6 6 5 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 CRG88002.1 - 0.013 14.5 7.7 0.17 10.9 0.5 4.0 5 0 0 5 5 5 0 Coatomer WD associated region TPR_1 PF00515.28 CRG88002.1 - 0.031 14.1 2.2 6.6 6.7 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5497 PF17601.2 CRG88002.1 - 0.07 13.4 1.4 13 6.2 0.2 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5497) TPR_14 PF13428.6 CRG88002.1 - 0.28 12.1 13.9 1.5 9.8 0.1 7.1 9 1 1 10 10 5 0 Tetratricopeptide repeat DUF1400 PF07176.11 CRG88002.1 - 1.6 9.0 5.2 9.1 6.6 0.0 4.3 4 0 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1400) Utp13 PF08625.11 CRG88002.1 - 5.7 6.8 10.5 4.1 7.3 0.1 5.0 6 1 1 7 7 7 0 Utp13 specific WD40 associated domain TPR_2 PF07719.17 CRG88002.1 - 7.4 7.0 12.2 7.8 6.9 0.1 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat CPSase_L_D2 PF02786.17 CRG88003.1 - 2.3e-81 272.3 0.1 4.1e-81 271.5 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 CRG88003.1 - 1.9e-69 233.4 0.0 3.3e-69 232.6 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain COesterase PF00135.28 CRG88003.1 - 7.7e-55 186.7 0.0 1.3e-54 185.9 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Biotin_carb_N PF00289.22 CRG88003.1 - 1.2e-38 132.1 0.0 2.6e-38 131.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CRG88003.1 - 2.6e-30 104.7 0.0 3e-29 101.3 0.0 2.6 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 CRG88003.1 - 1.6e-27 96.8 0.0 3e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 CRG88003.1 - 7.1e-18 64.2 4.0 7.1e-18 64.2 4.0 2.2 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 CRG88003.1 - 1e-09 38.0 5.2 1.5e-06 28.0 0.6 3.4 2 1 1 3 3 3 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 CRG88003.1 - 1.3e-09 37.8 0.0 2.6e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CRG88003.1 - 7.2e-07 28.9 0.0 1.8e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 CRG88003.1 - 6.9e-06 25.4 0.3 0.0071 15.6 0.1 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 CRG88003.1 - 1.2e-05 25.5 0.0 2.4e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 CRG88003.1 - 5.7e-05 23.8 1.5 0.38 11.5 0.0 3.0 3 0 0 3 3 3 2 HlyD family secretion protein RimK PF08443.11 CRG88003.1 - 7.4e-05 22.4 0.0 0.00016 21.4 0.0 1.5 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Abhydrolase_3 PF07859.13 CRG88003.1 - 0.0035 17.2 0.2 2.3 8.0 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold ATP-grasp_4 PF13535.6 CRG88003.1 - 0.027 14.0 0.0 0.087 12.4 0.0 1.9 2 0 0 2 2 2 0 ATP-grasp domain NQRA PF05896.11 CRG88003.1 - 0.029 13.8 0.3 0.05 13.0 0.3 1.2 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) DUF2118 PF09891.9 CRG88003.1 - 0.17 11.8 0.2 0.43 10.5 0.2 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) ATPgrasp_ST PF14397.6 CRG88003.1 - 0.18 11.0 0.0 0.5 9.6 0.0 1.6 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 CRG88003.1 - 0.33 10.9 0.9 1.2 9.0 0.4 2.1 1 1 0 1 1 1 0 Glycine cleavage H-protein Ribosomal_L5_C PF00673.21 CRG88005.1 - 4.8e-22 77.9 0.0 7.2e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 CRG88005.1 - 2.3e-20 72.7 0.0 7.4e-20 71.0 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 CRG88005.1 - 0.058 13.1 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain LSM PF01423.22 CRG88006.1 - 2e-20 72.2 0.0 2.5e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain MPC PF03650.13 CRG88007.1 - 3e-35 120.7 0.0 3.6e-35 120.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Phage_Coat_B PF05356.11 CRG88007.1 - 0.099 12.6 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Phage Coat protein B Aa_trans PF01490.18 CRG88008.1 - 2.2e-83 280.3 33.9 2.6e-83 280.0 33.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease PF00324.21 CRG88009.1 - 2.4e-55 188.0 35.7 3.1e-55 187.7 35.7 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 CRG88009.1 - 2.8e-19 69.5 4.8 7.2e-08 31.9 0.0 3.7 4 0 0 4 4 4 3 Solute carrier family 12 EIN3 PF04873.13 CRG88009.1 - 0.036 13.4 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 Ethylene insensitive 3 SDA1 PF05285.12 CRG88009.1 - 0.087 12.2 3.0 0.13 11.6 3.0 1.2 1 0 0 1 1 1 0 SDA1 TFIIF_alpha PF05793.12 CRG88009.1 - 0.25 9.9 10.6 0.4 9.2 10.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 CRG88009.1 - 0.51 8.5 5.4 0.72 8.0 5.4 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 CRG88009.1 - 1.5 8.1 8.4 2.4 7.4 8.4 1.2 1 0 0 1 1 1 0 NOA36 protein GHMP_kinases_N PF00288.26 CRG88010.1 - 6.6e-14 51.9 0.0 2.4e-13 50.1 0.0 2.0 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CRG88010.1 - 2.5e-06 27.8 0.0 8.6e-06 26.0 0.0 2.0 1 0 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 CRG88010.1 - 0.00071 19.1 0.1 0.0017 17.9 0.1 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Fungal_trans_2 PF11951.8 CRG88011.1 - 1.3e-27 96.6 0.3 2e-19 69.7 0.1 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88011.1 - 2.5e-08 33.9 7.9 3.8e-08 33.3 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2170 PF09938.9 CRG88012.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2170) AAA_30 PF13604.6 CRG88012.1 - 0.2 11.3 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sulfatase PF00884.23 CRG88013.1 - 7.7e-19 68.2 0.4 1.2e-18 67.6 0.4 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CRG88013.1 - 1.5e-07 31.4 0.0 2.7e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CRG88013.1 - 0.0093 14.6 0.0 0.014 14.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Equine_IAV_S2 PF06502.11 CRG88013.1 - 0.057 13.5 0.1 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 Equine infectious anaemia virus S2 protein PALP PF00291.25 CRG88014.1 - 3.6e-48 164.5 0.8 2.4e-47 161.7 0.3 1.9 1 1 1 2 2 2 2 Pyridoxal-phosphate dependent enzyme tRNA-synt_1g PF09334.11 CRG88015.1 - 1.2e-95 320.5 1.2 2.3e-94 316.3 1.2 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CRG88015.1 - 1.1e-24 86.7 0.7 3.9e-12 45.2 0.0 3.2 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 CRG88015.1 - 1e-10 41.5 0.0 1.5e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 CRG88015.1 - 1.7e-05 24.8 0.0 3.9e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA UBA_4 PF14555.6 CRG88015.1 - 0.15 11.9 0.0 1.1 9.2 0.1 2.3 2 0 0 2 2 2 0 UBA-like domain HTH_AraC PF00165.23 CRG88015.1 - 0.16 12.1 0.1 29 4.9 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family NTF2 PF02136.20 CRG88016.1 - 1.4e-07 32.1 0.1 3.5e-07 30.8 0.1 1.6 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 CRG88016.1 - 0.0046 16.9 0.1 0.03 14.3 0.1 1.9 2 0 0 2 2 2 1 Nuclear pore RNA shuttling protein Mtr2 Ish1 PF10281.9 CRG88017.1 - 5.4e-08 33.0 0.1 8.5e-08 32.4 0.1 1.3 1 0 0 1 1 1 1 Putative stress-responsive nuclear envelope protein SAP PF02037.27 CRG88017.1 - 0.0014 18.4 0.8 0.0089 15.8 0.8 2.0 1 1 0 1 1 1 1 SAP domain Ribosomal_L38e PF01781.18 CRG88018.1 - 2.3e-32 110.9 2.6 3.1e-32 110.5 2.6 1.2 1 0 0 1 1 1 1 Ribosomal L38e protein family Acetyltransf_3 PF13302.7 CRG88019.1 - 4.4e-18 66.3 0.0 6.3e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG88019.1 - 8.9e-06 25.6 0.1 0.0073 16.2 0.0 2.3 1 1 1 2 2 2 2 FR47-like protein Acetyltransf_1 PF00583.25 CRG88019.1 - 0.0019 18.4 0.0 0.093 13.0 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 CRG88019.1 - 0.0052 16.9 0.0 0.022 14.9 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 CRG88019.1 - 0.0065 16.2 0.0 0.45 10.2 0.0 2.3 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain 3Beta_HSD PF01073.19 CRG88020.1 - 3.9e-05 22.8 0.3 5.9e-05 22.2 0.3 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG88020.1 - 5.4e-05 22.8 1.1 8e-05 22.2 1.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG88020.1 - 0.00022 21.2 0.5 0.00028 20.8 0.5 1.3 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG88020.1 - 0.0027 17.3 0.8 0.0047 16.5 0.8 1.4 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CRG88020.1 - 0.016 14.6 0.7 0.028 13.8 0.7 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG88020.1 - 0.042 13.0 0.1 0.065 12.4 0.1 1.5 1 1 0 1 1 1 0 Male sterility protein RmlD_sub_bind PF04321.17 CRG88020.1 - 0.057 12.5 1.0 0.2 10.7 0.6 2.1 2 1 0 2 2 2 0 RmlD substrate binding domain DNA_pol_E_B PF04042.16 CRG88021.1 - 6.4e-44 149.8 0.0 8.7e-44 149.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 CRG88021.1 - 5.8e-37 126.7 0.0 1.1e-36 125.7 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain NMO PF03060.15 CRG88022.1 - 1.1e-57 195.9 0.4 1.4e-57 195.6 0.4 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CRG88022.1 - 4e-08 32.7 0.2 1.8e-06 27.2 0.0 2.3 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CRG88022.1 - 0.0036 16.4 2.4 0.0036 16.4 2.4 2.0 3 0 0 3 3 3 1 FMN-dependent dehydrogenase ATP-synt_I PF03899.15 CRG88022.1 - 0.0043 17.4 0.3 0.0084 16.5 0.3 1.4 1 0 0 1 1 1 1 ATP synthase I chain RuvA_C PF07499.13 CRG88022.1 - 0.13 12.7 0.3 2 9.0 0.0 2.6 3 0 0 3 3 3 0 RuvA, C-terminal domain Radial_spoke_3 PF06098.11 CRG88022.1 - 0.23 10.7 0.0 0.31 10.3 0.0 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 Taxilin PF09728.9 CRG88023.1 - 1.6e-89 300.1 65.6 1.6e-89 300.1 65.6 1.8 1 1 1 2 2 2 1 Myosin-like coiled-coil protein ERM PF00769.19 CRG88023.1 - 0.0095 15.8 19.0 0.0095 15.8 19.0 3.4 1 1 1 2 2 2 1 Ezrin/radixin/moesin family DUF3584 PF12128.8 CRG88023.1 - 0.93 6.9 51.7 2.2 5.7 51.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 CRG88023.1 - 1.6 9.1 55.6 2 8.8 20.8 3.1 1 1 2 3 3 3 0 Fez1 M16C_assoc PF08367.11 CRG88024.1 - 1.9e-71 240.1 0.0 2.8e-71 239.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 CRG88024.1 - 1.5e-20 74.0 0.0 6.7e-13 49.0 0.0 2.8 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CRG88024.1 - 4.3e-11 43.0 0.0 5.5e-10 39.4 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) adh_short PF00106.25 CRG88026.1 - 4.6e-22 78.4 0.0 5.9e-22 78.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88026.1 - 1e-15 58.0 0.0 1.3e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88026.1 - 0.0019 18.1 0.0 0.0031 17.5 0.0 1.3 1 1 0 1 1 1 1 KR domain Methyltransf_16 PF10294.9 CRG88028.1 - 9.1e-51 172.0 0.0 1.3e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 CRG88028.1 - 6.9e-05 23.5 0.0 0.0013 19.5 0.0 2.7 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88028.1 - 0.00091 19.1 0.0 0.0031 17.3 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 CRG88028.1 - 0.0012 18.4 0.1 0.0028 17.2 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CRG88028.1 - 0.0054 17.4 0.0 0.031 15.0 0.0 2.3 2 1 1 3 3 3 1 Methyltransferase domain Flagellin_N PF00669.20 CRG88028.1 - 0.037 14.1 0.1 0.075 13.1 0.1 1.5 1 0 0 1 1 1 0 Bacterial flagellin N-terminal helical region Methyltransf_2 PF00891.18 CRG88028.1 - 0.12 11.7 0.0 0.19 11.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain LtrA PF06772.11 CRG88029.1 - 7.6e-16 58.3 6.6 9.1e-16 58.0 6.6 1.0 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Orn_Arg_deC_N PF02784.16 CRG88030.1 - 2e-81 273.0 0.0 4.8e-81 271.8 0.0 1.6 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CRG88030.1 - 3.2e-19 69.0 0.0 4.9e-19 68.4 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 CRG88030.1 - 0.0002 20.9 0.0 0.00038 20.0 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Abhydrolase_3 PF07859.13 CRG88030.1 - 0.042 13.7 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3883 PF13020.6 CRG88031.1 - 0.0048 16.9 0.0 0.016 15.2 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3883) cobW PF02492.19 CRG88032.1 - 1.7e-41 141.8 0.0 2.3e-41 141.3 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 CRG88032.1 - 0.00087 19.2 0.0 0.0016 18.4 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B CobW_C PF07683.14 CRG88032.1 - 0.0017 18.2 0.0 0.034 14.1 0.0 2.5 1 1 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_22 PF13401.6 CRG88032.1 - 0.016 15.4 0.0 0.063 13.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 CRG88032.1 - 0.062 13.0 0.7 1.1 9.0 0.3 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 CRG88032.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Pox_A32 PF04665.12 CRG88032.1 - 0.1 12.1 0.1 0.21 11.0 0.0 1.4 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_33 PF13671.6 CRG88032.1 - 0.19 11.9 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain Med8 PF10232.9 CRG88033.1 - 0.041 13.5 2.3 0.045 13.3 2.3 1.2 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 DUF948 PF06103.11 CRG88033.1 - 0.055 13.7 1.2 0.055 13.7 1.2 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Haemagg_act PF05860.13 CRG88033.1 - 0.074 12.9 3.5 1.8 8.4 1.5 2.1 2 0 0 2 2 2 0 haemagglutination activity domain Phage_holin_7_1 PF16081.5 CRG88033.1 - 0.13 12.4 1.3 0.16 12.1 1.3 1.2 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family MRC1 PF09444.10 CRG88035.1 - 0.81 10.2 3.9 27 5.2 1.2 2.5 2 0 0 2 2 2 0 MRC1-like domain Mitofilin PF09731.9 CRG88036.1 - 1.5e-149 499.8 34.1 2.2e-121 406.7 31.4 2.2 1 1 1 2 2 2 2 Mitochondrial inner membrane protein Pex14_N PF04695.13 CRG88036.1 - 0.0029 18.3 3.3 0.0029 18.3 3.3 3.0 3 0 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Focal_AT PF03623.13 CRG88036.1 - 0.029 14.4 2.4 0.046 13.7 0.2 2.3 1 1 1 2 2 2 0 Focal adhesion targeting region HisK_N PF09385.10 CRG88036.1 - 0.041 13.8 0.8 0.15 12.0 0.8 1.9 1 1 0 1 1 1 0 Histidine kinase N terminal Cas_DxTHG PF09455.10 CRG88036.1 - 1.7 8.1 13.0 2.5 7.6 12.1 1.7 1 1 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family Ras PF00071.22 CRG88037.1 - 3.6e-59 199.0 0.2 4.1e-59 198.8 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG88037.1 - 1.4e-36 125.4 0.1 2.9e-36 124.3 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG88037.1 - 1.9e-14 53.5 0.0 2.3e-14 53.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CRG88037.1 - 4.9e-07 29.3 0.0 6.1e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CRG88037.1 - 7.7e-07 28.8 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 CRG88037.1 - 1.1e-06 28.7 0.0 1.7e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG88037.1 - 2.6e-05 24.2 1.2 0.19 11.6 0.2 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 CRG88037.1 - 0.013 15.9 0.1 0.024 15.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CRG88037.1 - 0.065 13.5 0.0 2.9 8.2 0.0 2.3 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.10 CRG88037.1 - 0.093 12.2 0.1 0.2 11.0 0.1 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Syja_N PF02383.18 CRG88038.1 - 3.9e-89 299.1 0.0 5e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain VirB3 PF05101.13 CRG88038.1 - 0.15 12.3 3.5 0.36 11.1 3.5 1.6 1 0 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein Mur_ligase_M PF08245.12 CRG88039.1 - 2e-06 28.0 0.6 9.4e-05 22.5 0.3 3.0 1 1 1 2 2 2 1 Mur ligase middle domain DUF2188 PF09954.9 CRG88039.1 - 0.019 15.1 0.1 0.28 11.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) NMT_C PF02799.15 CRG88040.1 - 2.4e-89 298.4 0.0 4.5e-89 297.5 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 CRG88040.1 - 8.6e-75 250.0 0.1 1.7e-73 245.7 0.0 2.3 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain TLD PF07534.16 CRG88040.1 - 3e-19 69.6 0.0 5.8e-19 68.7 0.0 1.5 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 CRG88040.1 - 1.1e-05 26.3 1.5 7.1e-05 23.8 0.5 2.7 2 0 0 2 2 2 1 Domain of unknown function Acetyltransf_9 PF13527.7 CRG88040.1 - 6.1e-05 23.1 0.3 0.0077 16.3 0.0 3.1 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Rrp40_N PF18311.1 CRG88040.1 - 0.009 15.9 0.8 0.02 14.9 0.8 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain Acetyltransf_1 PF00583.25 CRG88040.1 - 0.01 16.0 0.0 0.025 14.8 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Abhydrolase_6 PF12697.7 CRG88042.1 - 2e-07 31.9 0.0 3.3e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG88042.1 - 0.0011 18.2 0.0 0.0051 16.1 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CRG88042.1 - 0.05 13.5 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold GTP_EFTU PF00009.27 CRG88043.1 - 3.5e-57 193.1 0.2 5.9e-57 192.3 0.2 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 CRG88043.1 - 7.1e-34 115.8 0.0 1.6e-33 114.6 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 CRG88043.1 - 6.5e-33 113.1 0.0 1.2e-32 112.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CRG88043.1 - 4.8e-22 77.8 0.0 1.1e-21 76.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CRG88043.1 - 1.2e-12 48.1 0.1 2.5e-12 47.0 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 CRG88043.1 - 8.8e-07 28.8 0.0 2.8e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain ATP_bind_1 PF03029.17 CRG88043.1 - 0.0075 16.1 0.1 0.023 14.5 0.1 1.8 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein SFTA2 PF15210.6 CRG88043.1 - 0.065 13.2 0.0 0.34 10.9 0.0 2.0 2 0 0 2 2 2 0 Surfactant-associated protein 2 MMR_HSR1 PF01926.23 CRG88043.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase PALP PF00291.25 CRG88044.1 - 6.7e-76 255.5 0.1 8.1e-76 255.2 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 CRG88044.1 - 9.4e-43 143.9 0.0 3.2e-23 81.3 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Zn_clus PF00172.18 CRG88045.1 - 3.7e-08 33.4 11.0 6.7e-08 32.5 11.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HIG_1_N PF04588.13 CRG88046.1 - 1.7e-26 92.2 0.1 2.5e-26 91.6 0.1 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region JHY PF15261.6 CRG88046.1 - 0.0078 16.9 1.2 0.016 15.9 1.2 1.4 1 0 0 1 1 1 1 Jhy protein MAS20 PF02064.15 CRG88046.1 - 0.7 10.0 6.2 0.31 11.1 3.3 1.8 2 0 0 2 2 2 0 MAS20 protein import receptor Memo PF01875.17 CRG88047.1 - 2.3e-65 220.5 0.0 2.7e-65 220.2 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Metallophos PF00149.28 CRG88049.1 - 7.7e-37 127.8 0.1 1.2e-36 127.1 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CRG88049.1 - 7.3e-15 55.1 0.0 1.4e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain LSM PF01423.22 CRG88049.1 - 4.3e-06 26.3 0.0 8.1e-06 25.4 0.0 1.5 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CRG88049.1 - 0.1 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Ataxin 2 SM domain SOG2 PF10428.9 CRG88049.1 - 0.21 10.8 7.8 0.34 10.1 7.8 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Pkinase PF00069.25 CRG88050.1 - 1.2e-12 47.7 0.0 1.6e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88050.1 - 0.00028 20.3 0.0 0.00046 19.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 CRG88051.1 - 8.4e-15 54.9 1.3 0.34 11.8 0.0 9.0 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88051.1 - 6.6e-09 35.9 0.0 0.092 13.1 0.0 6.2 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CRG88051.1 - 8.2e-05 22.3 1.1 0.0072 15.9 0.2 3.5 4 0 0 4 4 4 1 PQQ-like domain Ge1_WD40 PF16529.5 CRG88051.1 - 0.22 10.5 0.0 1.1 8.1 0.0 2.2 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cyclin_N PF00134.23 CRG88052.1 - 7.8e-36 122.6 0.5 1.7e-35 121.6 0.2 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CRG88052.1 - 2.2e-11 43.8 1.0 4.5e-11 42.9 0.2 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain Abhydrolase_3 PF07859.13 CRG88053.1 - 2.7e-46 158.1 0.0 3.6e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG88053.1 - 5.6e-05 23.8 1.1 7.8e-05 23.4 1.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.28 CRG88053.1 - 0.0001 21.3 0.3 0.00021 20.3 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Epimerase PF01370.21 CRG88054.1 - 2.5e-13 50.1 0.0 5.6e-13 48.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG88054.1 - 1.3e-07 31.7 0.0 2.1e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG88054.1 - 2.1e-07 30.3 0.0 3.2e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG88054.1 - 2.1e-06 27.1 0.0 5e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG88054.1 - 2.3e-06 27.3 0.0 7.7e-06 25.5 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CRG88054.1 - 0.00015 21.4 0.1 0.00033 20.3 0.1 1.6 1 1 0 1 1 1 1 NmrA-like family KR PF08659.10 CRG88054.1 - 0.062 13.2 0.6 13 5.6 0.0 2.8 3 0 0 3 3 3 0 KR domain RmlD_sub_bind PF04321.17 CRG88054.1 - 0.082 12.0 0.0 9 5.3 0.0 2.2 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short PF00106.25 CRG88054.1 - 0.16 11.4 0.0 1.2 8.6 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase MCR_C PF04609.12 CRG88055.1 - 0.031 13.4 0.0 0.037 13.1 0.0 1.0 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein C DUF520 PF04461.13 CRG88055.1 - 0.041 14.0 0.2 0.048 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF520) Glyco_transf_34 PF05637.12 CRG88056.1 - 3.7e-11 43.2 0.1 1.5e-05 24.9 0.0 2.2 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family FmdA_AmdA PF03069.15 CRG88057.1 - 2.4e-56 191.2 0.0 2.7e-30 105.5 0.0 2.0 1 1 1 2 2 2 2 Acetamidase/Formamidase family MFS_1 PF07690.16 CRG88058.1 - 6.1e-31 107.6 71.7 2.5e-25 89.2 43.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UvrD-helicase PF00580.21 CRG88059.1 - 2.6e-62 211.1 0.4 6.7e-61 206.5 0.4 2.7 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 CRG88059.1 - 3e-60 204.4 0.0 1.9e-56 191.9 0.0 2.5 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CRG88059.1 - 1.1e-31 110.1 1.1 1.8e-30 106.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 CRG88059.1 - 4e-15 55.4 0.4 2.6e-14 52.8 0.1 2.4 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 CRG88059.1 - 2.2e-07 30.8 0.0 0.00055 19.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 CRG88059.1 - 0.00017 21.3 0.1 0.005 16.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CRG88059.1 - 0.0014 18.5 2.6 0.0036 17.1 0.4 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG88059.1 - 0.0064 16.8 0.3 4.2 7.6 0.1 2.8 2 0 0 2 2 2 2 AAA domain MiAMP1 PF09117.10 CRG88061.1 - 0.017 15.4 0.2 0.033 14.4 0.1 1.5 1 1 0 1 1 1 0 MiAMP1 Transferase PF02458.15 CRG88063.1 - 5.2e-19 68.2 0.0 1.3e-17 63.6 0.0 2.0 2 0 0 2 2 2 2 Transferase family CAT PF00302.18 CRG88063.1 - 0.2 11.6 0.0 0.33 10.9 0.0 1.2 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase HAUS-augmin3 PF14932.6 CRG88064.1 - 0.065 12.8 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DNA_pol_B_3 PF08408.10 CRG88064.1 - 0.07 13.3 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase family B viral insert FAM220 PF15487.6 CRG88064.1 - 0.14 11.8 3.2 0.26 10.9 0.0 2.4 2 0 0 2 2 2 0 FAM220 family LAT PF15234.6 CRG88065.1 - 0.008 15.9 4.1 0.0098 15.6 4.1 1.1 1 0 0 1 1 1 1 Linker for activation of T-cells DUF4083 PF13314.6 CRG88065.1 - 0.25 11.3 4.2 0.36 10.8 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) DUF3377 PF11857.8 CRG88065.1 - 0.6 10.1 2.4 0.92 9.5 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) TMIE PF16038.5 CRG88065.1 - 3.4 7.6 4.1 1.5 8.7 1.0 2.0 2 0 0 2 2 2 0 TMIE protein FKBP_C PF00254.28 CRG88066.1 - 2.9e-32 110.8 0.0 3.6e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Cyt-b5 PF00173.28 CRG88067.1 - 1.3e-14 54.1 0.0 1.9e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SPX PF03105.19 CRG88067.1 - 0.12 12.3 6.7 0.13 12.2 6.7 1.1 1 0 0 1 1 1 0 SPX domain PP2C PF00481.21 CRG88068.1 - 1e-38 133.5 0.0 1.1e-38 133.3 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 CRG88068.1 - 7.7e-07 28.9 0.0 2.2e-06 27.5 0.0 1.8 1 1 0 1 1 1 1 Protein phosphatase 2C Bunya_G1 PF03557.15 CRG88068.1 - 0.049 11.6 0.0 0.066 11.2 0.0 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G1 SpoIIE PF07228.12 CRG88068.1 - 0.12 12.3 0.0 10 6.0 0.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Vg_Tdu PF07545.14 CRG88068.1 - 4.9 7.0 5.0 7.3 6.5 0.1 2.9 3 0 0 3 3 3 0 Vestigial/Tondu family MFS_1 PF07690.16 CRG88069.1 - 4.1e-30 104.9 44.6 1.4e-29 103.1 44.6 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Ank_2 PF12796.7 CRG88070.1 - 4.2e-24 85.0 3.6 6.3e-11 42.7 0.1 3.4 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88070.1 - 1.1e-12 48.2 0.1 2.7e-06 27.8 0.0 3.9 2 2 3 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG88070.1 - 4.3e-12 45.1 0.3 0.064 13.8 0.0 6.0 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 CRG88070.1 - 7.2e-11 42.0 0.4 0.0016 18.8 0.0 5.4 5 1 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 CRG88070.1 - 1.9e-10 40.8 1.2 1.1e-05 25.6 0.1 4.8 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Shigella_OspC PF06128.11 CRG88070.1 - 0.0096 15.7 0.2 0.13 12.0 0.1 2.1 2 0 0 2 2 2 1 Shigella flexneri OspC protein c-SKI_SMAD_bind PF08782.10 CRG88071.1 - 0.76 10.0 2.5 17 5.7 0.1 2.3 1 1 1 2 2 2 0 c-SKI Smad4 binding domain Glyco_hydro_114 PF03537.13 CRG88072.1 - 3.8e-73 245.6 0.2 4.4e-73 245.4 0.2 1.0 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 Sugar_tr PF00083.24 CRG88073.1 - 3.1e-53 181.2 28.2 3.4e-51 174.5 28.2 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88073.1 - 1.5e-14 53.8 36.8 7.1e-08 31.8 13.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG88073.1 - 0.017 13.7 0.3 0.017 13.7 0.3 3.4 3 1 0 3 3 3 0 MFS/sugar transport protein DMT_YdcZ PF04657.13 CRG88073.1 - 0.058 13.7 18.4 0.047 14.0 2.5 3.6 3 0 0 3 3 3 0 Putative inner membrane exporter, YdcZ Zip PF02535.22 CRG88074.1 - 4.5e-67 226.6 5.6 5.1e-67 226.5 5.6 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter SPT2 PF08243.11 CRG88074.1 - 0.059 13.9 0.2 0.087 13.4 0.2 1.1 1 0 0 1 1 1 0 SPT2 chromatin protein DctQ PF04290.12 CRG88074.1 - 5.6 6.9 16.7 0.29 11.1 3.0 3.3 4 0 0 4 4 4 0 Tripartite ATP-independent periplasmic transporters, DctQ component Tom37 PF10568.9 CRG88075.1 - 1.1e-38 132.4 0.7 1.8e-38 131.6 0.7 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 CRG88075.1 - 2.7e-08 33.5 0.0 2e-07 30.7 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG88075.1 - 4.8e-07 30.5 0.1 5.7e-05 23.8 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain DUF3322 PF11795.8 CRG88075.1 - 0.14 12.2 1.3 0.72 9.8 0.2 2.7 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) 4HBT_3 PF13622.6 CRG88076.1 - 3e-45 155.4 0.1 3.8e-45 155.1 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CRG88076.1 - 0.026 14.4 0.0 0.062 13.1 0.0 1.6 2 0 0 2 2 2 0 Acyl-CoA thioesterase 4HBT_3 PF13622.6 CRG88077.1 - 0.015 15.6 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 Thioesterase-like superfamily Nepo_coat PF03391.15 CRG88077.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Nepovirus coat protein, central domain Peptidase_U4 PF03419.13 CRG88078.1 - 0.2 10.9 3.0 0.23 10.7 3.0 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Abhydrolase_3 PF07859.13 CRG88079.1 - 8.6e-23 81.3 0.0 1.3e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG88079.1 - 1.3e-19 70.4 0.0 1.8e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_1 PF00561.20 CRG88079.1 - 0.0015 18.3 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG88079.1 - 0.0069 17.0 0.2 0.012 16.2 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Rad4 PF03835.15 CRG88079.1 - 0.019 14.6 0.4 0.31 10.7 0.1 2.2 2 0 0 2 2 2 0 Rad4 transglutaminase-like domain Thymidylat_synt PF00303.19 CRG88080.1 - 3.2e-106 354.4 0.0 4.4e-106 353.9 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase Hist_deacetyl PF00850.19 CRG88082.1 - 1.1e-77 261.6 0.1 1.4e-77 261.2 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain FMO-like PF00743.19 CRG88083.1 - 6e-11 41.5 0.3 1.2e-10 40.4 0.0 1.7 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG88083.1 - 6.9e-05 22.2 0.0 0.13 11.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG88083.1 - 0.00082 18.6 0.0 0.11 11.6 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG88083.1 - 0.0058 15.9 0.0 0.052 12.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase adh_short_C2 PF13561.6 CRG88084.1 - 4e-67 226.2 0.9 4.5e-67 226.0 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG88084.1 - 3.2e-54 183.3 0.2 4e-54 183.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG88084.1 - 9e-13 48.5 0.8 1.3e-12 48.0 0.8 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG88084.1 - 0.12 11.8 0.3 0.68 9.3 0.1 1.9 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family APH PF01636.23 CRG88085.1 - 1.5e-05 25.1 0.0 0.0001 22.3 0.0 2.3 2 1 0 2 2 2 1 Phosphotransferase enzyme family Fructosamin_kin PF03881.14 CRG88085.1 - 0.14 11.3 0.0 2.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Fructosamine kinase DUF3237 PF11578.8 CRG88086.1 - 1.8e-39 135.0 0.0 2e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Oxysterol_BP PF01237.18 CRG88087.1 - 4.1e-89 299.0 0.0 5.6e-86 288.7 0.0 2.1 1 1 0 1 1 1 1 Oxysterol-binding protein DUF3605 PF12239.8 CRG88088.1 - 2.1e-55 187.3 1.1 2.6e-55 187.0 1.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) SH3_1 PF00018.28 CRG88090.1 - 2.9e-11 42.8 0.0 4.7e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG88090.1 - 5.1e-09 35.8 0.0 1e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CRG88090.1 - 3.5e-07 29.8 0.0 6.2e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF3692 PF12469.8 CRG88090.1 - 0.17 12.1 0.0 0.68 10.2 0.1 1.9 2 0 0 2 2 2 0 CRISPR-associated protein DUF4091 PF13320.6 CRG88090.1 - 0.33 11.1 4.0 0.38 10.9 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4091) Pro_isomerase PF00160.21 CRG88091.1 - 1.3e-45 155.5 1.8 1.4e-45 155.4 1.1 1.4 1 1 1 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RNase_PH PF01138.21 CRG88092.1 - 1.1e-32 113.3 0.2 2.9e-32 111.9 0.2 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 SNF2_N PF00176.23 CRG88093.1 - 1.5e-51 175.2 0.1 2.5e-51 174.5 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 CRG88093.1 - 2.6e-25 88.3 0.1 2.6e-25 88.3 0.1 2.2 2 0 0 2 2 2 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 CRG88093.1 - 8.9e-23 80.8 0.0 2.8e-18 66.3 0.0 3.5 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88093.1 - 1.6e-08 34.8 0.2 8.2e-08 32.4 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG88093.1 - 1.1e-06 28.1 0.1 2.3e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 CRG88093.1 - 0.00058 19.7 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase YL1 PF05764.13 CRG88093.1 - 0.74 9.9 16.1 2.2 8.3 16.1 1.8 1 0 0 1 1 1 0 YL1 nuclear protein Acyl-CoA_dh_1 PF00441.24 CRG88094.1 - 1e-16 61.5 0.3 7.8e-16 58.6 0.3 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 CRG88094.1 - 5.6e-14 52.3 0.0 9.4e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 CRG88094.1 - 3e-12 46.6 0.0 5.9e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CRG88094.1 - 0.064 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Ssu72 PF04722.13 CRG88095.1 - 1.7e-84 282.2 0.0 2e-84 281.9 0.0 1.1 1 0 0 1 1 1 1 Ssu72-like protein Isochorismatase PF00857.20 CRG88096.1 - 4.4e-23 82.3 0.1 3.7e-22 79.3 0.1 2.0 1 1 0 1 1 1 1 Isochorismatase family HMG-CoA_red PF00368.18 CRG88097.1 - 4.2e-141 470.2 5.2 1.4e-140 468.5 5.5 1.6 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 CRG88097.1 - 1.9e-45 154.5 0.0 3.5e-45 153.7 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 CRG88097.1 - 1.1e-14 54.5 4.4 3.3e-14 53.0 4.4 1.8 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 CRG88097.1 - 1.7e-08 33.1 0.9 1.7e-08 33.1 0.9 1.5 2 0 0 2 2 2 1 Patched family GIT_SHD PF08518.11 CRG88098.1 - 1.3e-24 85.4 5.6 2e-13 49.7 0.6 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 CRG88098.1 - 8.4e-05 22.7 0.0 8.4e-05 22.7 0.0 3.1 2 1 2 4 4 4 1 G protein-coupled receptor kinase-interacting protein 1 C term APG6_N PF17675.1 CRG88098.1 - 0.0082 16.7 16.9 0.0082 16.7 16.9 2.8 1 1 1 2 2 2 1 Apg6 coiled-coil region EzrA PF06160.12 CRG88098.1 - 0.018 13.2 22.6 0.26 9.4 5.9 2.2 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA Fmp27_WPPW PF10359.9 CRG88098.1 - 0.041 12.8 25.7 1.7e+02 0.8 25.7 2.2 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Fib_alpha PF08702.10 CRG88098.1 - 0.099 12.8 19.6 1 9.6 10.4 3.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family XLF PF09302.11 CRG88098.1 - 0.1 12.8 5.3 0.056 13.6 2.2 2.1 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component TMF_TATA_bd PF12325.8 CRG88098.1 - 0.35 11.1 31.4 2 8.7 10.4 3.9 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 CRG88098.1 - 0.81 9.8 30.1 0.23 11.6 0.9 4.7 3 1 1 4 4 4 0 bZIP transcription factor Gp-FAR-1 PF05823.12 CRG88098.1 - 0.89 9.9 6.9 6.3 7.1 1.6 2.8 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CALCOCO1 PF07888.11 CRG88098.1 - 0.99 8.2 35.1 2.6 6.8 14.2 2.3 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Prefoldin_2 PF01920.20 CRG88098.1 - 1.2 9.1 32.7 2.7 8.0 1.9 4.7 2 2 1 3 3 3 0 Prefoldin subunit DUF4407 PF14362.6 CRG88098.1 - 1.5 8.1 22.1 2.8 7.2 19.3 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) HCMV_UL139 PF12507.8 CRG88098.1 - 1.6 9.1 10.5 0.9 9.9 0.2 3.6 2 1 2 4 4 4 0 Human Cytomegalovirus UL139 protein CLZ PF16526.5 CRG88098.1 - 3.1 8.2 29.4 0.94 9.9 2.0 5.4 4 1 1 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF948 PF06103.11 CRG88098.1 - 3.2 8.1 6.7 2.5 8.4 0.2 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.11 CRG88098.1 - 5.4 7.2 34.1 3.4 7.9 9.9 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TINF2_N PF14973.6 CRG88098.1 - 7 7.0 10.2 0.69 10.3 3.4 2.9 2 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus HIP1_clath_bdg PF16515.5 CRG88098.1 - 7.1 7.3 32.3 9.4 6.9 15.2 3.6 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ERM PF00769.19 CRG88098.1 - 7.9 6.2 38.4 0.32 10.8 18.5 3.2 2 1 1 3 3 3 0 Ezrin/radixin/moesin family Gly_transf_sug PF04488.15 CRG88099.1 - 5.2e-10 39.8 0.0 1.2e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif DUF4692 PF15763.5 CRG88099.1 - 0.00062 20.3 3.1 0.00062 20.3 3.1 2.1 2 0 0 2 2 2 1 Regulator of human erythroid cell expansion (RHEX) SR-25 PF10500.9 CRG88099.1 - 0.0016 18.1 11.3 0.0016 18.1 11.3 2.3 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Connexin PF00029.19 CRG88099.1 - 0.028 14.2 0.3 0.83 9.4 0.2 2.3 2 0 0 2 2 2 0 Connexin ENTH PF01417.20 CRG88100.1 - 7.6e-46 155.2 0.3 1.2e-45 154.6 0.3 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 CRG88100.1 - 3.4e-05 23.0 0.0 4.8e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 CRG88100.1 - 0.1 12.5 0.0 0.21 11.4 0.0 1.5 1 1 0 1 1 1 0 VHS domain GRP PF07172.11 CRG88100.1 - 0.96 10.2 16.0 2.3 9.0 16.0 1.5 1 0 0 1 1 1 0 Glycine rich protein family RasGAP_C PF03836.15 CRG88101.1 - 9.2e-49 165.1 5.1 9.2e-49 165.1 5.1 3.0 2 0 0 2 2 2 1 RasGAP C-terminus RasGAP PF00616.19 CRG88101.1 - 5.3e-46 156.9 0.0 2.2e-45 155.0 0.0 2.1 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase IQ PF00612.27 CRG88101.1 - 2e-12 45.8 52.9 1.3 9.0 0.4 15.2 15 1 0 15 15 15 10 IQ calmodulin-binding motif CH PF00307.31 CRG88101.1 - 2.4e-10 40.5 0.3 2.4e-09 37.4 0.0 2.5 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 CRG88101.1 - 0.0017 18.1 0.0 0.0044 16.8 0.0 1.7 1 0 0 1 1 1 1 CAMSAP CH domain DUF3855 PF12967.7 CRG88101.1 - 0.087 12.8 0.0 0.74 9.8 0.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3855) Acylphosphatase PF00708.18 CRG88101.1 - 0.21 12.0 6.1 3.9 7.9 0.1 3.8 3 0 0 3 3 3 0 Acylphosphatase NMO PF03060.15 CRG88101.1 - 0.23 10.8 2.7 11 5.3 0.3 2.5 1 1 1 2 2 2 0 Nitronate monooxygenase Trypan_PARP PF05887.11 CRG88101.1 - 0.35 10.9 2.9 0.79 9.7 2.9 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF952 PF06108.12 CRG88102.1 - 2.9e-16 59.2 0.0 7.1e-16 58.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF952) IMPDH PF00478.25 CRG88103.1 - 1.2e-127 425.7 1.0 1.3e-127 425.5 1.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 CRG88103.1 - 1.5e-18 67.0 0.1 8.4e-10 39.0 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 CRG88103.1 - 1.6e-07 30.7 0.8 9.8e-07 28.1 0.4 2.2 3 0 0 3 3 3 1 FMN-dependent dehydrogenase NMO PF03060.15 CRG88103.1 - 1.2e-05 24.9 5.5 0.0098 15.3 3.4 2.5 3 0 0 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 CRG88103.1 - 0.00044 19.8 2.2 0.015 14.8 0.3 2.2 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 CRG88103.1 - 0.042 13.2 0.6 0.1 11.9 0.6 1.6 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG PK PF00224.21 CRG88103.1 - 0.071 12.0 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Pyruvate kinase, barrel domain QRPTase_C PF01729.19 CRG88103.1 - 0.11 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain Glu_synthase PF01645.17 CRG88103.1 - 0.13 11.3 2.5 0.28 10.3 1.6 1.9 2 0 0 2 2 2 0 Conserved region in glutamate synthase YpsA PF06908.11 CRG88103.1 - 0.2 11.6 0.0 0.42 10.6 0.0 1.4 1 0 0 1 1 1 0 YspA SLOG family Ribosomal_S21e PF01249.18 CRG88104.1 - 1.8e-39 133.7 0.1 1.8e-38 130.5 0.1 2.3 2 0 0 2 2 2 1 Ribosomal protein S21e NUDIX PF00293.28 CRG88104.1 - 3.8e-07 30.2 0.0 8.9e-07 29.0 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain tRNA-synt_2d PF01409.20 CRG88105.1 - 3.3e-88 295.3 0.0 4.3e-88 294.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 CRG88105.1 - 1.6e-15 57.1 0.6 1.6e-15 57.1 0.6 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 CRG88105.1 - 7.2e-07 28.9 0.0 0.012 15.0 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 CRG88105.1 - 4e-05 22.8 0.2 0.0023 17.1 0.0 3.0 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 CRG88105.1 - 0.00012 22.0 1.7 0.00061 19.7 1.7 2.3 1 1 0 1 1 1 1 PheRS DNA binding domain 2 HAMP PF00672.25 CRG88106.1 - 1.2e-42 144.1 13.6 2.7e-08 34.1 0.0 7.2 6 0 0 6 6 6 5 HAMP domain HATPase_c PF02518.26 CRG88106.1 - 8.7e-33 113.2 0.3 4.4e-32 110.9 0.1 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG88106.1 - 1.6e-25 89.5 0.9 5.1e-25 87.8 0.6 2.1 2 0 0 2 2 1 1 Response regulator receiver domain MFS_1 PF07690.16 CRG88106.1 - 3.6e-17 62.3 41.4 1.4e-14 53.8 41.4 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily HisKA PF00512.25 CRG88106.1 - 9.7e-17 60.8 0.4 8e-16 57.8 0.1 3.0 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain Syntaxin_2 PF14523.6 CRG88106.1 - 3e-07 30.7 6.6 2 8.9 0.0 6.3 2 2 1 5 5 5 1 Syntaxin-like protein TPR_2 PF07719.17 CRG88106.1 - 8.9e-05 22.3 8.5 12 6.3 0.1 6.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG88106.1 - 0.00045 20.6 1.1 3.4 8.6 0.1 3.7 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF4279 PF14106.6 CRG88106.1 - 0.00056 20.1 0.0 21 5.3 0.0 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4279) TPR_12 PF13424.6 CRG88106.1 - 0.0018 18.5 0.3 0.47 10.8 0.0 3.5 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF948 PF06103.11 CRG88106.1 - 0.0036 17.5 47.3 2.2 8.6 1.5 8.7 3 1 3 6 6 6 2 Bacterial protein of unknown function (DUF948) DUF3829 PF12889.7 CRG88106.1 - 0.024 14.1 12.1 0.15 11.5 1.2 4.5 3 2 2 5 5 5 0 Protein of unknown function (DUF3829) Pox_Ag35 PF03286.14 CRG88106.1 - 0.053 13.3 4.6 0.32 10.8 4.6 2.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOD PF06816.13 CRG88106.1 - 0.15 11.7 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 NOTCH protein Fib_alpha PF08702.10 CRG88106.1 - 0.2 11.8 29.6 2 8.6 0.6 7.1 6 1 1 7 7 7 0 Fibrinogen alpha/beta chain family TPR_1 PF00515.28 CRG88106.1 - 0.2 11.5 3.0 70 3.5 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 CRG88106.1 - 0.28 11.6 9.3 0.87 10.0 9.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ArsR PF09824.9 CRG88106.1 - 0.43 10.2 4.4 14 5.2 0.1 4.1 2 1 1 3 3 3 0 ArsR transcriptional regulator DUF4746 PF15928.5 CRG88106.1 - 0.7 9.3 4.1 1.5 8.2 4.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM176 PF14851.6 CRG88106.1 - 0.81 9.3 3.8 2.4 7.8 3.8 1.8 1 0 0 1 1 1 0 FAM176 family SpoIIID PF12116.8 CRG88106.1 - 1.2 9.3 6.6 22 5.3 0.1 4.9 5 0 0 5 5 4 0 Stage III sporulation protein D DUF1759 PF03564.15 CRG88106.1 - 2 8.3 4.0 47 3.9 0.0 4.0 3 1 0 4 4 3 0 Protein of unknown function (DUF1759) WXG100 PF06013.12 CRG88106.1 - 2.8 8.2 24.3 13 6.1 0.9 7.5 8 1 0 8 8 6 0 Proteins of 100 residues with WXG BORCS6 PF10157.9 CRG88106.1 - 5.1 7.3 10.1 47 4.2 0.0 4.8 3 2 1 4 4 4 0 BLOC-1-related complex sub-unit 6 ApoLp-III PF07464.11 CRG88106.1 - 6.3 6.9 28.1 5.3 7.1 9.4 5.6 2 1 3 5 5 5 0 Apolipophorin-III precursor (apoLp-III) NOA36 PF06524.12 CRG88106.1 - 8.9 5.5 12.0 16 4.7 12.0 1.2 1 0 0 1 1 1 0 NOA36 protein Fungal_trans PF04082.18 CRG88107.1 - 1e-12 47.7 0.0 2.3e-12 46.5 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF4939 PF16297.5 CRG88108.1 - 0.0032 17.3 0.1 0.0087 15.9 0.0 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4939) DUF3138 PF11336.8 CRG88108.1 - 0.0038 15.9 0.4 0.0047 15.6 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3138) DUF4055 PF13264.6 CRG88108.1 - 0.061 13.5 0.5 0.096 12.8 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) DUF4509 PF14970.6 CRG88108.1 - 0.081 12.8 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) RVP_2 PF08284.11 CRG88109.1 - 3.7e-11 42.9 0.0 5.3e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 CRG88109.1 - 4.2e-09 36.8 0.0 6.6e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CRG88109.1 - 6.9e-08 33.0 0.0 1.2e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Aspartyl protease Peptidase_A2E PF12382.8 CRG88109.1 - 0.013 15.5 0.0 0.022 14.8 0.0 1.3 1 0 0 1 1 1 0 Retrotransposon peptidase Asp_protease PF09668.10 CRG88109.1 - 0.023 14.5 0.0 0.038 13.8 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease RVP PF00077.20 CRG88109.1 - 0.13 12.5 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 Retroviral aspartyl protease MFS_1 PF07690.16 CRG88111.1 - 2.4e-29 102.4 57.4 8.6e-29 100.6 43.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sigma_reg_N PF13800.6 CRG88113.1 - 3.7 7.9 6.4 2.4 8.5 0.4 3.0 2 1 1 3 3 3 0 Sigma factor regulator N-terminal NAD_binding_6 PF08030.12 CRG88114.1 - 1.4e-07 31.7 0.0 1.8e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FtsJ PF01728.19 CRG88115.1 - 9.4e-13 48.6 0.0 1.4e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CRG88115.1 - 0.029 14.2 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ifi-6-16 PF06140.13 CRG88118.1 - 0.042 13.7 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 Interferon-induced 6-16 family Ank_2 PF12796.7 CRG88119.1 - 1.7e-39 134.2 7.9 7.2e-11 42.5 0.0 5.6 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88119.1 - 6.2e-30 103.2 4.6 8.7e-07 29.4 0.2 7.4 5 2 3 8 8 8 6 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG88119.1 - 3e-24 84.8 8.2 0.00021 21.5 0.1 9.6 5 3 5 10 10 10 7 Ankyrin repeats (many copies) Ank PF00023.30 CRG88119.1 - 1.1e-21 76.3 18.8 0.043 14.3 0.1 10.0 10 0 0 10 10 10 6 Ankyrin repeat Ank_3 PF13606.6 CRG88119.1 - 9.4e-19 65.6 8.1 0.43 11.3 0.0 10.0 10 0 0 10 10 10 5 Ankyrin repeat Acetyltransf_10 PF13673.7 CRG88119.1 - 3e-08 33.7 0.0 5.3e-08 32.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG88119.1 - 7.8e-05 23.0 0.0 0.00026 21.3 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF1843 PF08898.10 CRG88119.1 - 0.012 16.1 9.1 0.87 10.1 0.2 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1843) Acetyltransf_1 PF00583.25 CRG88119.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family MFS_1 PF07690.16 CRG88120.1 - 1.2e-35 123.1 34.8 1.2e-35 123.1 34.8 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG88120.1 - 1.3e-12 47.0 13.8 1.8e-12 46.5 13.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG88120.1 - 1.3e-07 30.9 1.5 1.3e-07 30.9 1.5 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 CRG88120.1 - 0.26 9.5 4.9 0.14 10.4 0.3 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Pkinase PF00069.25 CRG88121.1 - 1e-72 244.7 0.0 1.7e-72 243.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88121.1 - 4.1e-36 124.6 0.0 1.2e-35 123.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG88121.1 - 0.0027 17.1 0.7 2.5 7.3 0.0 2.9 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 CRG88121.1 - 0.013 15.5 2.3 0.04 13.8 0.0 2.7 2 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG88121.1 - 0.18 10.6 0.0 0.18 10.6 0.0 2.3 3 1 1 4 4 4 0 Fungal protein kinase BSMAP PF12280.8 CRG88121.1 - 7.4 6.7 6.9 3.1 8.0 0.2 3.2 4 0 0 4 4 4 0 Brain specific membrane anchored protein MRP-L28 PF09812.9 CRG88121.1 - 9.7 6.3 9.6 4.1 7.5 1.4 3.5 4 0 0 4 4 4 0 Mitochondrial ribosomal protein L28 MFS_1 PF07690.16 CRG88122.1 - 9.5e-27 93.8 35.2 1.3e-16 60.5 23.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88122.1 - 1.1e-14 54.1 25.2 5.4e-12 45.3 7.1 3.1 2 1 1 3 3 3 3 Sugar (and other) transporter DUF4579 PF15158.6 CRG88122.1 - 0.39 10.4 2.3 0.59 9.9 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) FAD_binding_7 PF03441.14 CRG88123.1 - 3.4e-79 265.0 1.4 5.4e-79 264.4 1.4 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 CRG88123.1 - 4.8e-41 140.5 0.2 8.5e-41 139.7 0.2 1.3 1 0 0 1 1 1 1 DNA photolyase Fungal_trans PF04082.18 CRG88124.1 - 8.6e-10 38.1 1.1 1.5e-09 37.3 1.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DivIC PF04977.15 CRG88124.1 - 0.028 14.2 1.0 0.045 13.5 0.2 1.7 2 0 0 2 2 2 0 Septum formation initiator Zn_clus PF00172.18 CRG88124.1 - 0.034 14.3 8.8 0.26 11.5 8.8 2.3 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Lzipper-MIP1 PF14389.6 CRG88124.1 - 0.13 12.6 0.7 1.9 8.8 0.0 2.4 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 GRDP-like PF07173.12 CRG88125.1 - 4.7e-19 69.4 5.3 4.6e-14 53.3 0.2 3.2 3 0 0 3 3 3 2 Glycine-rich domain-containing protein-like F-box PF00646.33 CRG88126.1 - 0.0066 16.3 0.0 0.023 14.6 0.0 2.0 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CRG88126.1 - 0.036 14.0 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 F-box-like Fungal_trans PF04082.18 CRG88127.1 - 1.3e-12 47.3 0.0 2.4e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88127.1 - 2.1e-06 27.7 6.4 4.1e-06 26.8 6.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta_elim_lyase PF01212.21 CRG88128.1 - 7.7e-70 235.5 0.0 9.4e-70 235.2 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase NIF PF03031.18 CRG88130.1 - 1.1e-40 138.9 0.0 1.6e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase JAB PF01398.21 CRG88131.1 - 3.5e-33 114.1 0.0 6.7e-33 113.2 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 CRG88131.1 - 3.1e-12 46.9 0.6 5.1e-12 46.2 0.6 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 CRG88131.1 - 2.3e-07 30.6 0.0 5.8e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain UCR_14kD PF02271.16 CRG88131.1 - 0.078 12.9 0.3 0.2 11.6 0.1 1.8 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex 14kD subunit Hist_deacetyl PF00850.19 CRG88132.1 - 2.8e-81 273.4 0.0 5.6e-81 272.4 0.0 1.5 1 0 0 1 1 1 1 Histone deacetylase domain Ribosomal_L14 PF00238.19 CRG88132.1 - 8.1e-33 113.1 0.1 2.1e-32 111.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L14p/L23e CS PF04969.16 CRG88132.1 - 6.5e-16 59.1 0.5 1.7e-15 57.8 0.0 2.0 2 0 0 2 2 2 1 CS domain tRNA-synt_2 PF00152.20 CRG88133.1 - 2.1e-90 303.0 0.0 3.4e-90 302.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CRG88133.1 - 0.0052 16.8 0.0 0.012 15.5 0.0 1.7 1 1 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 CRG88133.1 - 0.024 14.6 0.0 0.046 13.7 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2d PF01409.20 CRG88133.1 - 0.16 11.4 0.3 0.33 10.4 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA-synt_1b PF00579.25 CRG88134.1 - 6.9e-75 252.1 0.0 9.5e-75 251.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 CRG88134.1 - 2.1e-41 140.5 0.0 3.7e-41 139.7 0.0 1.4 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain MutS_V PF00488.21 CRG88135.1 - 9.6e-68 227.9 0.1 1.7e-67 227.1 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CRG88135.1 - 7.4e-40 137.2 0.0 1.7e-39 136.0 0.0 1.7 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CRG88135.1 - 3.8e-34 117.3 0.1 1.2e-33 115.7 0.0 1.9 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 CRG88135.1 - 1.3e-15 57.9 0.0 3.7e-15 56.4 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CRG88135.1 - 1.3e-12 47.8 0.1 4.2e-12 46.2 0.3 1.8 2 0 0 2 2 2 1 MutS family domain IV AAA_23 PF13476.6 CRG88135.1 - 0.0036 17.8 0.1 0.0036 17.8 0.1 2.5 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 CRG88135.1 - 0.032 14.0 0.1 0.074 12.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 CRG88135.1 - 0.065 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CRG88135.1 - 0.26 11.8 2.0 1 9.9 0.1 2.9 3 0 0 3 3 3 0 ABC transporter Nucleo_P87 PF07267.11 CRG88135.1 - 0.89 8.3 12.2 1.6 7.5 12.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AAA_21 PF13304.6 CRG88135.1 - 2.5 7.8 8.2 0.1 12.3 0.2 2.4 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Peptidase_M28 PF04389.17 CRG88137.1 - 6.8e-32 110.8 0.1 1e-31 110.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 SMI1_KNR4 PF09346.10 CRG88137.1 - 0.01 16.2 0.0 0.019 15.4 0.0 1.5 1 0 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) Sulf_transp PF04143.14 CRG88138.1 - 0.00075 19.2 3.4 0.00075 19.2 3.4 2.1 2 0 0 2 2 2 1 Sulphur transport MFS_MOT1 PF16983.5 CRG88139.1 - 6.7e-61 203.6 32.7 3.6e-33 114.3 9.7 2.7 3 0 0 3 3 3 2 Molybdate transporter of MFS superfamily PhyH PF05721.13 CRG88140.1 - 1.2e-44 153.1 0.1 1.6e-44 152.7 0.1 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 CRG88140.1 - 0.0067 16.8 0.0 0.015 15.7 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Cupin_2 PF07883.11 CRG88140.1 - 0.13 12.0 0.1 2.4 8.0 0.0 2.7 3 1 0 3 3 3 0 Cupin domain Fungal_trans PF04082.18 CRG88142.1 - 5.4e-27 94.5 0.1 5.4e-27 94.5 0.1 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88142.1 - 9.6e-06 25.6 9.2 2.4e-05 24.3 9.2 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UTP15_C PF09384.10 CRG88143.1 - 6.2e-52 175.2 0.1 1.7e-51 173.8 0.2 1.7 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.32 CRG88143.1 - 4.1e-18 65.4 6.1 0.00022 21.9 0.0 6.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88143.1 - 1.3e-08 35.0 0.1 0.099 13.0 0.0 4.9 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CRG88143.1 - 0.00085 19.0 2.3 0.0054 16.3 0.3 2.4 1 1 1 2 2 2 1 PQQ-like domain RAB3GAP2_N PF14655.6 CRG88143.1 - 0.017 14.4 0.4 1.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus PHTB1_N PF14727.6 CRG88143.1 - 0.14 11.5 0.0 0.38 10.1 0.0 1.7 2 0 0 2 2 2 0 PTHB1 N-terminus PQQ_3 PF13570.6 CRG88143.1 - 1.1 9.9 4.3 1.1e+02 3.5 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain MFS_1 PF07690.16 CRG88144.1 - 1.6e-31 109.6 26.3 1.6e-31 109.6 26.3 1.8 3 0 0 3 3 3 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG88144.1 - 1.7e-14 53.5 0.0 3.1e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88144.1 - 0.00014 21.9 12.5 0.00026 21.1 12.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain betaPIX_CC PF16523.5 CRG88144.1 - 0.0082 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 betaPIX coiled coil p450 PF00067.22 CRG88145.1 - 7.1e-51 173.4 0.0 1.1e-50 172.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.8 CRG88146.1 - 1.4e-08 34.0 2.6 1.7e-07 30.4 0.1 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain PQ-loop PF04193.14 CRG88147.1 - 1.9e-33 114.0 8.2 1.7e-18 66.1 0.5 3.2 3 0 0 3 3 3 2 PQ loop repeat SnoaL_2 PF12680.7 CRG88147.1 - 0.00014 22.4 0.0 0.0003 21.4 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 CRG88147.1 - 0.0021 18.6 0.0 0.005 17.4 0.0 1.6 2 0 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain C2 PF00168.30 CRG88148.1 - 2.1e-16 60.1 0.0 3.4e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 C2 domain Tmemb_170 PF10190.9 CRG88150.1 - 0.017 15.5 1.7 0.017 15.5 1.7 2.7 3 0 0 3 3 3 0 Putative transmembrane protein 170 Claudin_3 PF06653.11 CRG88150.1 - 0.046 13.7 13.1 0.58 10.1 13.1 2.3 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF1616 PF07760.11 CRG88150.1 - 0.29 10.5 2.9 0.19 11.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) Clc-like PF07062.12 CRG88150.1 - 3.4 7.1 11.9 0.11 11.9 0.5 2.4 1 1 1 2 2 2 0 Clc-like RRM_1 PF00076.22 CRG88151.1 - 3.6e-46 154.9 0.5 3.5e-15 55.6 0.0 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG88151.1 - 6.4e-37 125.3 0.0 2.2e-27 94.7 0.0 4.1 4 0 0 4 4 4 3 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 CRG88151.1 - 1.7e-07 31.1 0.1 0.022 14.7 0.0 3.0 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CRG88151.1 - 0.0013 18.8 5.6 2 8.5 0.0 4.4 3 1 1 4 4 4 2 RNA binding motif Nup35_RRM PF05172.13 CRG88151.1 - 0.02 14.9 0.0 0.11 12.5 0.0 2.2 1 1 1 2 2 2 0 Nup53/35/40-type RNA recognition motif CKAP2_C PF15297.6 CRG88151.1 - 0.037 13.1 4.4 0.067 12.3 4.4 1.3 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus Lsm_interact PF05391.11 CRG88151.1 - 0.063 12.8 2.4 0.14 11.7 2.4 1.6 1 0 0 1 1 1 0 Lsm interaction motif TPR_14 PF13428.6 CRG88151.1 - 0.07 14.0 5.0 16 6.7 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Ribosomal_L22 PF00237.19 CRG88152.1 - 1.8e-31 108.4 0.1 4e-31 107.3 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e SR-25 PF10500.9 CRG88153.1 - 0.0069 16.0 13.5 0.01 15.5 13.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 CRG88153.1 - 0.027 14.2 5.5 0.048 13.4 5.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CCDC24 PF15669.5 CRG88153.1 - 1.5 8.7 6.0 2.9 7.7 6.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family His_Phos_1 PF00300.22 CRG88154.1 - 3e-09 36.9 0.1 1.4e-08 34.7 0.1 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) NAGLU PF05089.12 CRG88155.1 - 4e-134 446.8 5.8 5.8e-134 446.2 5.8 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 CRG88155.1 - 8.9e-73 245.1 5.4 1.4e-72 244.5 5.4 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 CRG88155.1 - 5e-21 74.3 0.0 1.3e-20 72.9 0.0 1.8 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Abhydrolase_6 PF12697.7 CRG88156.1 - 2.4e-15 57.8 0.1 3.1e-15 57.4 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG88156.1 - 2.5e-12 47.0 0.1 8.3e-12 45.3 0.1 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG88156.1 - 1.7e-09 37.3 0.0 2.7e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 CRG88156.1 - 0.033 14.1 0.0 0.18 11.7 0.0 2.0 2 1 0 2 2 2 0 Serine hydrolase Ehrlichia_rpt PF09528.10 CRG88156.1 - 0.096 12.2 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Ehrlichia tandem repeat (Ehrlichia_rpt) MARVEL PF01284.23 CRG88158.1 - 6.1e-24 84.7 9.0 7.2e-24 84.4 9.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF3611 PF12263.8 CRG88158.1 - 0.066 13.1 2.6 3.1 7.7 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) ABC2_membrane_5 PF13346.6 CRG88158.1 - 0.28 10.7 6.7 0.41 10.2 6.7 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein Suc_Fer-like PF06999.12 CRG88159.1 - 1e-67 227.8 0.0 1.2e-67 227.6 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Fungal_trans PF04082.18 CRG88160.1 - 5.5e-11 42.0 0.0 9.7e-11 41.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88160.1 - 1.2e-08 34.9 7.5 2.5e-08 33.9 7.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Drc1-Sld2 PF11719.8 CRG88161.1 - 3.3e-107 359.8 32.3 9.5e-107 358.3 32.3 1.6 1 1 0 1 1 1 1 DNA replication and checkpoint protein GDPD PF03009.17 CRG88161.1 - 0.11 12.2 3.5 0.22 11.2 3.5 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family YCII PF03795.14 CRG88162.1 - 0.0099 16.3 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 1 YCII-related domain p450 PF00067.22 CRG88163.1 - 2.3e-59 201.4 0.0 8.2e-30 103.9 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 MFS_1 PF07690.16 CRG88163.1 - 5.4e-14 51.9 28.4 5.4e-14 51.9 28.4 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF5464 PF17552.2 CRG88163.1 - 0.0091 16.2 1.2 4.7 7.6 0.2 3.6 2 0 0 2 2 2 2 Family of unknown function (DUF5464) adh_short PF00106.25 CRG88164.1 - 2.1e-17 63.2 0.1 2.6e-17 62.9 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88164.1 - 1.2e-07 31.5 0.1 1.4e-07 31.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88164.1 - 9.4e-06 25.6 0.1 1.3e-05 25.2 0.1 1.1 1 0 0 1 1 1 1 KR domain DUF1729 PF08354.10 CRG88165.1 - 1.7e-143 477.8 0.0 2.5e-143 477.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 CRG88165.1 - 2.3e-54 185.1 0.0 6.6e-54 183.6 0.0 1.8 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 CRG88165.1 - 1.1e-38 132.4 0.1 4.7e-38 130.3 0.0 2.2 2 0 0 2 2 2 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 CRG88165.1 - 6.4e-30 104.6 0.0 1.7e-29 103.3 0.0 1.7 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 CRG88165.1 - 1.8e-26 92.1 0.0 7.8e-26 90.0 0.0 2.0 2 0 0 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CRG88165.1 - 1.7e-18 67.1 0.0 1.3e-16 60.9 0.0 3.3 3 0 0 3 3 3 1 N-terminal half of MaoC dehydratase FAS_N PF17828.1 CRG88165.1 - 4.9e-05 23.3 0.1 0.0001 22.3 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta Fas_alpha_ACP PF18325.1 CRG88166.1 - 1.2e-59 201.3 0.1 3.9e-59 199.6 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 CRG88166.1 - 2.6e-34 118.6 0.0 5.4e-34 117.6 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 CRG88166.1 - 1.9e-22 80.1 0.0 5.2e-22 78.6 0.0 1.7 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CRG88166.1 - 4.3e-11 42.9 0.0 1e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 CRG88166.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 CRG88166.1 - 0.076 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase ABC_tran PF00005.27 CRG88167.1 - 1.2e-34 119.8 0.0 3.1e-26 92.5 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG88167.1 - 4.1e-30 105.4 37.7 2.3e-25 89.8 17.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 CRG88167.1 - 1e-06 28.8 0.3 0.45 10.3 0.0 3.3 2 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG88167.1 - 0.00012 21.6 0.5 0.5 9.8 0.0 3.2 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG88167.1 - 0.0075 16.7 0.1 0.038 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 CRG88167.1 - 0.018 14.8 0.1 0.042 13.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG88167.1 - 0.023 14.6 0.1 0.078 12.9 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase DUF87 PF01935.17 CRG88167.1 - 0.042 13.9 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 CRG88167.1 - 0.061 13.4 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 CRG88167.1 - 0.13 12.6 0.0 0.52 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain YrhC PF14143.6 CRG88167.1 - 7.2 6.8 9.2 20 5.4 0.3 3.7 3 0 0 3 3 3 0 YrhC-like protein Aminotran_4 PF01063.19 CRG88168.1 - 6.4e-33 114.5 0.0 8e-33 114.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV RTA1 PF04479.13 CRG88169.1 - 3.7e-48 163.9 7.0 4.5e-48 163.6 7.0 1.1 1 0 0 1 1 1 1 RTA1 like protein Aminotran_4 PF01063.19 CRG88170.1 - 4.8e-28 98.5 0.0 5.9e-28 98.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV AMP-binding PF00501.28 CRG88172.1 - 0 1249.2 0.0 9e-77 258.4 0.0 5.3 5 0 0 5 5 5 5 AMP-binding enzyme Condensation PF00668.20 CRG88172.1 - 1.8e-258 857.6 11.0 1.9e-52 178.5 0.0 9.9 9 1 0 9 9 9 8 Condensation domain PP-binding PF00550.25 CRG88172.1 - 4.4e-50 167.9 6.7 3e-13 49.9 0.1 5.9 5 0 0 5 5 5 5 Phosphopantetheine attachment site NAD_binding_4 PF07993.12 CRG88172.1 - 2.4e-40 138.3 0.0 5.9e-40 137.1 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein AMP-binding_C PF13193.6 CRG88172.1 - 5.9e-14 52.8 0.1 0.00023 22.1 0.0 5.9 5 0 0 5 5 5 3 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 CRG88172.1 - 1.3e-10 41.2 0.0 2.9e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Transferase PF02458.15 CRG88172.1 - 0.0053 15.5 0.1 0.55 8.8 0.0 3.3 3 0 0 3 3 3 1 Transferase family GDP_Man_Dehyd PF16363.5 CRG88172.1 - 0.0098 15.3 0.0 0.031 13.7 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF600 PF04634.12 CRG88172.1 - 0.3 11.1 0.7 17 5.4 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function, DUF600 Glyco_hydro_43 PF04616.14 CRG88173.1 - 3.5e-38 131.6 1.3 4.7e-38 131.2 1.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Cellulase PF00150.18 CRG88174.1 - 2e-20 73.4 3.0 2.6e-20 73.0 3.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 CRG88174.1 - 0.0013 18.0 0.0 0.0033 16.6 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_42 PF02449.15 CRG88174.1 - 0.025 13.9 0.1 0.039 13.3 0.1 1.2 1 0 0 1 1 1 0 Beta-galactosidase Glyco_hydro_10 PF00331.20 CRG88174.1 - 0.046 12.9 0.1 0.094 11.9 0.1 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 MFS_1 PF07690.16 CRG88175.1 - 1.9e-29 102.7 20.5 2.2e-29 102.5 20.5 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG88175.1 - 5.1e-05 22.7 1.9 0.0001 21.7 1.9 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB HAD_SAK_1 PF10307.9 CRG88177.1 - 2.6e-74 249.4 0.0 3.8e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins zf-RING_2 PF13639.6 CRG88178.1 - 1.4e-10 41.3 4.1 2.7e-10 40.4 4.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CRG88178.1 - 1.5e-08 34.4 2.0 2.1e-08 33.9 2.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG88178.1 - 1.6e-07 31.0 4.7 2.5e-07 30.4 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CRG88178.1 - 5.7e-07 29.7 1.8 5.7e-07 29.7 1.8 1.9 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 CRG88178.1 - 1.1e-06 28.4 3.6 1.7e-06 27.7 3.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG88178.1 - 4.2e-05 23.3 3.2 6.9e-05 22.6 3.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 CRG88178.1 - 0.015 15.3 1.2 0.031 14.3 1.2 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 CRG88178.1 - 0.079 13.0 1.5 0.12 12.5 0.5 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 CRG88178.1 - 0.091 12.7 2.8 0.17 11.9 2.8 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 CRG88178.1 - 8.8 6.2 11.7 0.076 12.8 2.7 2.1 2 0 0 2 2 2 0 RING-like zinc finger MAM33 PF02330.16 CRG88179.1 - 7e-68 228.7 1.1 8.6e-68 228.4 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein MeaB PF03308.16 CRG88179.1 - 0.082 11.9 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Tma16 PF11176.8 CRG88180.1 - 5.5e-48 162.6 1.9 6.7e-48 162.3 1.9 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 Syntaxin PF00804.25 CRG88180.1 - 0.1 12.3 1.5 0.15 11.7 0.5 1.7 1 1 1 2 2 2 0 Syntaxin XPG_I PF00867.18 CRG88181.1 - 3.9e-24 84.8 0.0 9.4e-24 83.6 0.0 1.7 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 CRG88181.1 - 1.3e-22 80.2 0.0 3.1e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I_2 PF12813.7 CRG88181.1 - 9.4e-05 22.0 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 CRG88181.1 - 0.0088 16.6 0.0 0.028 15.0 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold TPR_8 PF13181.6 CRG88181.1 - 0.034 14.4 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88181.1 - 0.039 14.1 0.1 0.12 12.6 0.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Fig1 PF12351.8 CRG88182.1 - 9e-57 192.0 7.2 9e-57 192.0 7.2 2.0 2 0 0 2 2 2 2 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 CRG88182.1 - 7e-07 29.1 9.2 1e-06 28.6 9.2 1.3 1 0 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 CRG88182.1 - 0.00065 18.9 4.2 0.00065 18.9 4.2 1.8 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF898) Ferlin_C PF16165.5 CRG88182.1 - 3.3 7.7 4.3 1.9 8.4 0.5 2.4 2 0 0 2 2 2 0 Ferlin C-terminus NAD_binding_6 PF08030.12 CRG88183.1 - 3.9e-08 33.6 0.0 6.6e-07 29.6 0.0 2.3 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG88183.1 - 3.5e-07 30.3 0.0 0.014 15.5 0.0 2.5 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 CRG88183.1 - 0.0029 18.2 0.0 0.017 15.8 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain Fungal_trans_2 PF11951.8 CRG88184.1 - 1.2e-08 34.2 0.0 1.7e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88184.1 - 5.1e-06 26.5 8.0 5.1e-06 26.5 8.0 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 CRG88185.1 - 4.7e-39 134.4 0.3 2.6e-26 92.4 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 DNA_primase_S PF01896.19 CRG88186.1 - 6.5e-59 198.9 0.2 1.1e-58 198.2 0.2 1.3 1 0 0 1 1 1 1 DNA primase small subunit BCS1_N PF08740.11 CRG88188.1 - 3.2e-32 112.0 0.1 4.8e-32 111.5 0.1 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CRG88188.1 - 7.4e-17 62.0 0.0 5.5e-08 33.3 0.0 2.5 1 1 1 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CRG88188.1 - 0.0079 16.5 0.1 0.027 14.7 0.1 1.9 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CRG88188.1 - 0.03 14.3 0.0 0.088 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG88188.1 - 0.044 14.2 0.1 0.1 12.9 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 CRG88188.1 - 0.063 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 CRG88188.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 KaiC RR_TM4-6 PF06459.12 CRG88189.1 - 8.3 6.1 8.3 17 5.1 8.3 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Coatomer_WDAD PF04053.14 CRG88191.1 - 4.4e-141 470.9 0.2 1.6e-140 469.1 0.0 1.9 2 0 0 2 2 2 1 Coatomer WD associated region COPI_C PF06957.11 CRG88191.1 - 1.7e-106 356.4 0.0 2.6e-106 355.8 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 CRG88191.1 - 8.7e-39 130.8 18.5 4.2e-08 33.7 0.3 7.7 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88191.1 - 6.6e-09 36.0 0.3 0.45 10.8 0.0 5.7 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG88191.1 - 0.0058 15.3 7.5 0.15 10.7 0.2 3.4 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Clathrin PF00637.20 CRG88191.1 - 0.055 13.3 0.7 0.19 11.6 0.0 2.3 3 0 0 3 3 3 0 Region in Clathrin and VPS Evr1_Alr PF04777.13 CRG88192.1 - 2.8e-25 88.7 0.7 4.8e-25 87.9 0.2 1.6 2 0 0 2 2 2 1 Erv1 / Alr family Bd3614-deam PF14439.6 CRG88192.1 - 0.038 14.1 0.1 3.4 7.8 0.1 2.2 2 0 0 2 2 2 0 Bd3614-like deaminase GREB1 PF15782.5 CRG88193.1 - 8 3.4 16.9 10 3.1 16.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Adaptin_N PF01602.20 CRG88194.1 - 1.6e-138 462.5 4.8 2.1e-138 462.2 4.8 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 CRG88194.1 - 4.2e-65 218.7 1.8 1e-60 204.4 0.5 2.6 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 CRG88194.1 - 5e-17 62.1 5.0 4.1e-07 30.3 0.0 6.1 2 1 5 7 7 7 5 HEAT repeats HEAT PF02985.22 CRG88194.1 - 2.7e-13 48.9 3.2 0.015 15.5 0.0 6.8 6 0 0 6 6 6 3 HEAT repeat Arm PF00514.23 CRG88194.1 - 0.00053 19.9 0.6 12 6.1 0.0 5.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 CRG88194.1 - 0.0009 18.9 0.1 1.2 8.6 0.0 3.8 2 1 2 4 4 4 1 CLASP N terminal RTP1_C1 PF10363.9 CRG88194.1 - 0.016 15.4 0.4 3.9 7.7 0.0 4.1 2 2 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Atx10homo_assoc PF09759.9 CRG88194.1 - 0.094 12.7 0.1 14 5.8 0.0 3.5 3 1 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 CRG88194.1 - 0.24 12.0 12.3 0.4 11.2 0.0 6.0 7 1 1 8 8 8 0 HEAT-like repeat CAAP1 PF15335.6 CRG88194.1 - 0.51 10.9 1.9 0.8 10.3 0.1 2.3 3 0 0 3 3 3 0 Caspase activity and apoptosis inhibitor 1 TBCC PF07986.12 CRG88195.1 - 1.6e-30 105.3 0.4 2.6e-30 104.6 0.4 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 CRG88195.1 - 1.3e-08 35.2 0.1 2.2e-08 34.5 0.1 1.3 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain Pro-kuma_activ PF09286.11 CRG88197.1 - 1.4e-36 125.9 0.0 3.4e-36 124.6 0.0 1.7 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG88197.1 - 8.9e-07 28.4 0.1 1.6e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Subtilase family CSN8_PSD8_EIF3K PF10075.9 CRG88198.1 - 4.6e-20 72.1 0.0 1.1e-19 70.9 0.0 1.6 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 CRG88198.1 - 0.024 14.0 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 SAC3/GANP family WD40 PF00400.32 CRG88199.1 - 0.0019 19.0 0.4 23 6.1 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF1917 PF08939.10 CRG88200.1 - 4.7e-78 262.7 0.0 5.6e-78 262.4 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) Vps51 PF08700.11 CRG88201.1 - 6.1e-26 90.3 0.2 1.4e-25 89.2 0.0 1.7 2 0 0 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 CRG88201.1 - 0.045 13.9 0.1 0.095 12.9 0.0 1.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Dor1 PF04124.12 CRG88201.1 - 0.08 11.6 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Dor1-like family FlgN PF05130.12 CRG88201.1 - 0.082 13.4 0.9 8.5 6.9 0.1 2.9 1 1 1 2 2 2 0 FlgN protein DUF3678 PF12435.8 CRG88201.1 - 0.13 11.7 0.2 0.13 11.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) RMI1_N PF08585.12 CRG88202.1 - 3.1e-57 193.8 0.0 3.9e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 RecQ mediated genome instability protein TPR_2 PF07719.17 CRG88203.1 - 1.9e-26 90.0 43.1 0.029 14.5 0.0 15.8 16 0 0 16 16 15 8 Tetratricopeptide repeat TPR_16 PF13432.6 CRG88203.1 - 1.4e-25 89.7 44.5 2.8e-06 27.9 4.3 11.9 10 2 3 13 13 12 6 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88203.1 - 1.1e-21 75.6 30.1 0.14 13.1 0.0 14.4 11 4 3 14 14 13 5 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88203.1 - 2.8e-21 73.9 26.5 0.054 13.7 0.0 13.7 15 0 0 15 15 14 6 Tetratricopeptide repeat TPR_1 PF00515.28 CRG88203.1 - 1.2e-20 72.4 27.9 0.0026 17.5 0.0 12.7 12 0 0 12 12 12 6 Tetratricopeptide repeat TPR_11 PF13414.6 CRG88203.1 - 1.3e-20 72.8 15.3 4.5e-05 23.0 0.0 9.8 9 2 1 10 10 10 5 TPR repeat TPR_17 PF13431.6 CRG88203.1 - 1e-19 69.4 17.8 0.042 14.2 0.0 13.9 14 0 0 14 14 13 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88203.1 - 1.1e-18 67.5 23.4 0.0012 19.3 0.4 10.9 10 1 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 CRG88203.1 - 2.1e-15 56.8 36.1 7e-08 32.7 0.0 11.4 10 2 1 11 11 10 4 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88203.1 - 5.6e-11 41.7 19.2 0.021 14.8 0.0 10.1 10 1 1 11 11 10 4 Tetratricopeptide repeat TPR_6 PF13174.6 CRG88203.1 - 5.7e-06 26.6 27.6 1.1 10.1 0.0 11.1 14 0 0 14 14 10 2 Tetratricopeptide repeat TPR_22 PF18833.1 CRG88203.1 - 7.4e-06 26.0 0.0 2.3e-05 24.4 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 CRG88203.1 - 6.4e-05 23.0 14.7 0.27 11.4 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat FAT PF02259.23 CRG88203.1 - 0.0022 17.3 7.4 1.1 8.4 0.2 4.5 5 0 0 5 5 5 2 FAT domain ChAPs PF09295.10 CRG88203.1 - 0.0082 15.2 2.5 56 2.6 0.1 5.8 5 2 1 6 6 6 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_4 PF07721.14 CRG88203.1 - 0.061 14.0 7.4 54 4.8 0.0 6.3 7 0 0 7 7 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CRG88203.1 - 0.064 13.3 1.0 6.9 6.8 0.0 4.5 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat ANAPC5 PF12862.7 CRG88203.1 - 0.1 12.7 4.4 12 6.0 0.6 4.4 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 5 PPTA PF01239.22 CRG88203.1 - 0.13 12.0 0.1 19 5.1 0.0 3.4 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat DUF2225 PF09986.9 CRG88203.1 - 0.18 11.5 2.9 3 7.5 0.1 3.8 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) TerB PF05099.13 CRG88203.1 - 1.7 8.6 7.8 3.2 7.7 0.2 3.6 3 0 0 3 3 3 0 Tellurite resistance protein TerB Glyco_hydro_5_C PF18564.1 CRG88204.1 - 1.3e-24 86.5 0.0 3.7e-24 85.1 0.0 1.8 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Fungal_trans PF04082.18 CRG88204.1 - 7.6e-12 44.8 0.8 1.6e-11 43.7 0.8 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cellulase PF00150.18 CRG88204.1 - 1.7e-08 34.2 6.3 6.9e-07 29.0 4.1 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 CRG88204.1 - 0.024 14.0 0.2 2.6 7.3 0.0 2.3 2 0 0 2 2 2 0 Beta-galactosidase EKLF_TAD1 PF16832.5 CRG88204.1 - 0.04 13.8 0.7 0.13 12.2 0.5 1.9 2 0 0 2 2 2 0 Erythroid krueppel-like transcription factor, transactivation 1 Xpo1 PF08389.12 CRG88205.1 - 2.1e-10 40.8 0.5 1.1e-08 35.2 0.1 3.8 3 1 0 3 3 3 1 Exportin 1-like protein Arm PF00514.23 CRG88205.1 - 0.59 10.3 3.1 0.46 10.6 0.4 2.4 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat GRIM-19 PF06212.12 CRG88206.1 - 1.1e-23 83.7 0.6 4.1e-23 81.8 0.6 1.7 1 1 0 1 1 1 1 GRIM-19 protein tRNA_m1G_MT PF01746.21 CRG88207.1 - 2.5e-27 95.9 0.2 6.6e-20 71.6 0.0 2.2 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase ORC_WH_C PF18137.1 CRG88207.1 - 0.061 13.4 0.6 0.061 13.4 0.6 2.8 2 1 0 2 2 2 0 Origin recognition complex winged helix C-terminal VID27 PF08553.10 CRG88208.1 - 3.8e-195 647.9 0.2 5.1e-195 647.5 0.2 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 CRG88208.1 - 3.7e-76 254.8 0.6 3.7e-76 254.8 0.6 3.6 3 1 1 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 CRG88208.1 - 1.3e-48 163.8 2.2 5.4e-48 161.8 1.4 2.2 2 0 0 2 2 2 1 VID27 PH-like domain CENP-B_dimeris PF09026.10 CRG88208.1 - 1.5 9.3 18.5 0.32 11.4 8.6 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain TRAP_alpha PF03896.16 CRG88208.1 - 3.3 6.8 9.5 7.6 5.7 9.5 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TLD PF07534.16 CRG88209.1 - 1.4e-25 90.1 0.0 1.8e-15 57.4 0.0 2.2 2 0 0 2 2 2 2 TLD JAB PF01398.21 CRG88210.1 - 7.2e-18 64.7 0.0 1.5e-17 63.7 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 CRG88210.1 - 1.9e-09 37.7 0.7 4.2e-09 36.6 0.7 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 CRG88210.1 - 0.00012 21.8 0.0 0.00035 20.3 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain RrnaAD PF00398.20 CRG88211.1 - 3.6e-06 26.2 0.0 7.2e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase VIR_N PF15912.5 CRG88211.1 - 0.12 12.0 3.0 0.24 11.0 3.0 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal Aldedh PF00171.22 CRG88212.1 - 7e-123 410.5 0.0 8.9e-123 410.2 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Pkinase PF00069.25 CRG88213.1 - 8.3e-15 54.9 0.0 3.2e-14 53.0 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88213.1 - 1.6e-06 27.6 0.0 2.5e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG88213.1 - 0.0069 15.2 0.0 0.01 14.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 CRG88213.1 - 0.0083 16.1 0.2 0.03 14.3 0.2 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CRG88213.1 - 0.08 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family ADH_zinc_N PF00107.26 CRG88214.1 - 1.5e-08 34.6 0.0 3.1e-08 33.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88214.1 - 0.001 18.9 0.1 0.0024 17.7 0.1 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CRG88214.1 - 0.0013 19.8 0.0 0.0028 18.7 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Iso_dh PF00180.20 CRG88215.1 - 4.8e-66 223.3 0.0 6.2e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase FTHFS PF01268.19 CRG88216.1 - 3.4e-255 847.5 0.0 5.1e-255 846.9 0.0 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 CRG88216.1 - 1.7e-66 222.5 0.7 1.7e-66 222.5 0.7 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 CRG88216.1 - 3.8e-28 98.1 0.3 1.3e-27 96.4 0.3 2.0 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GTP_EFTU PF00009.27 CRG88216.1 - 0.041 13.4 0.4 0.12 11.9 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Helicase_C_4 PF13871.6 CRG88216.1 - 0.051 13.2 0.0 0.085 12.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue WD40 PF00400.32 CRG88217.1 - 2.4e-27 94.6 0.2 1.4e-07 32.1 0.1 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88217.1 - 9.7e-12 45.0 0.1 0.016 15.5 0.0 5.4 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 CRG88217.1 - 0.00016 21.5 0.1 0.00023 21.0 0.1 1.2 1 0 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain PQQ_2 PF13360.6 CRG88217.1 - 0.014 15.0 0.8 0.16 11.5 0.3 2.5 1 1 1 2 2 2 0 PQQ-like domain Nup160 PF11715.8 CRG88217.1 - 0.02 13.5 0.2 0.086 11.5 0.1 2.0 2 1 0 2 2 2 0 Nucleoporin Nup120/160 WD40_like PF17005.5 CRG88217.1 - 0.034 13.5 0.0 4.7 6.4 0.0 2.8 2 1 1 3 3 3 0 WD40-like domain Cytochrom_D1 PF02239.16 CRG88217.1 - 0.039 12.5 0.4 0.35 9.3 0.1 2.4 2 1 0 3 3 3 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 CRG88217.1 - 0.16 10.9 0.0 6.8 5.5 0.0 2.2 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain MBF1 PF08523.10 CRG88218.1 - 1.5e-24 86.2 2.1 3.2e-24 85.2 2.1 1.5 1 0 0 1 1 1 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 CRG88218.1 - 4.5e-11 42.6 0.0 7.5e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 CRG88218.1 - 5.6e-06 26.6 0.0 1.3e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain GATase_6 PF13522.6 CRG88219.1 - 2.5e-14 53.6 0.0 5.3e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain SH3_1 PF00018.28 CRG88219.1 - 4.8e-14 51.7 0.0 8.8e-14 50.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain GATase_7 PF13537.6 CRG88219.1 - 2.7e-13 49.9 0.0 5.6e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain SH3_9 PF14604.6 CRG88219.1 - 1e-12 47.7 0.0 1.9e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 CRG88219.1 - 4.8e-07 29.4 0.0 1e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Pribosyltran PF00156.27 CRG88219.1 - 1.9e-06 27.5 0.0 6.2e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MFS_1 PF07690.16 CRG88219.1 - 0.00015 20.8 27.7 0.00032 19.7 26.9 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily GATase_4 PF13230.6 CRG88219.1 - 0.0016 17.4 0.0 0.0028 16.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II PA PF02225.22 CRG88219.1 - 0.26 11.3 1.0 0.84 9.7 0.1 2.2 2 1 0 2 2 2 0 PA domain Ank_2 PF12796.7 CRG88220.1 - 1.9e-18 66.8 4.3 1.8e-11 44.5 0.8 4.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88220.1 - 2.4e-17 63.0 0.5 9.2e-09 35.7 0.0 4.6 2 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG88220.1 - 6.8e-13 48.6 3.2 7.6e-05 22.9 0.2 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG88220.1 - 1e-12 47.0 1.1 0.0021 18.4 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 CRG88220.1 - 1.5e-09 37.9 3.2 0.0031 17.9 0.0 4.4 3 0 0 3 3 3 3 Ankyrin repeat AIM24 PF01987.17 CRG88221.1 - 1.8e-49 168.3 0.0 2.4e-49 167.9 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 eIF-5_eIF-2B PF01873.17 CRG88221.1 - 3.2e-40 136.6 0.1 5.5e-40 135.9 0.1 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 zf-HYPF PF07503.12 CRG88221.1 - 0.58 10.0 2.3 54 3.7 3.9 2.9 2 1 1 3 3 3 0 HypF finger Arc_trans_TRASH PF08394.10 CRG88221.1 - 8.9 6.7 7.5 2.9 8.3 0.4 2.5 1 1 1 2 2 2 0 Archaeal TRASH domain PI-PLC-C1 PF16670.5 CRG88222.1 - 0.16 11.0 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Phosphoinositide phospholipase C, Ca2+-dependent Zn_clus PF00172.18 CRG88223.1 - 0.16 12.1 8.7 0.27 11.4 8.7 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DisA_N PF02457.16 CRG88224.1 - 0.062 12.9 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 DisA bacterial checkpoint controller nucleotide-binding PhnG PF06754.12 CRG88224.1 - 0.11 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphonate metabolism protein PhnG RRM_1 PF00076.22 CRG88226.1 - 1.8e-23 82.1 0.0 2.3e-23 81.8 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG88226.1 - 0.0029 17.7 0.0 0.0049 17.0 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif RRM_occluded PF16842.5 CRG88226.1 - 0.036 13.9 0.0 0.065 13.1 0.0 1.4 1 1 0 1 1 1 0 Occluded RNA-recognition motif ChaC PF04752.12 CRG88227.1 - 1.7e-52 178.1 0.0 2.2e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein adh_short PF00106.25 CRG88228.1 - 4.1e-16 59.0 0.0 1e-15 57.7 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88228.1 - 3.7e-09 36.5 0.0 1.7e-08 34.4 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88228.1 - 5.5e-09 36.2 0.0 9e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 KR domain MFS_1 PF07690.16 CRG88229.1 - 1.1e-48 166.0 54.2 1.1e-47 162.7 54.2 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG88229.1 - 5.7e-25 87.8 12.0 8.7e-25 87.2 12.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) EF-hand_1 PF00036.32 CRG88229.1 - 6.4e-19 66.0 8.8 6e-06 25.4 0.1 5.1 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CRG88229.1 - 7.1e-19 66.1 1.8 3.1e-06 26.7 0.1 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 CRG88229.1 - 4.2e-18 65.6 1.6 1.1e-07 32.2 2.7 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 CRG88229.1 - 2.4e-17 62.5 3.6 4.5e-07 29.6 0.0 3.7 3 0 0 3 3 3 3 EF-hand domain pair Sugar_tr PF00083.24 CRG88229.1 - 1.4e-14 53.9 6.9 1.4e-14 53.9 6.9 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter EF-hand_5 PF13202.6 CRG88229.1 - 4.6e-13 48.0 5.4 0.00011 21.5 0.6 4.5 4 1 0 4 4 4 3 EF hand MFS_2 PF13347.6 CRG88229.1 - 0.00048 18.8 4.4 0.00048 18.8 4.4 3.1 3 1 1 4 4 4 2 MFS/sugar transport protein Caleosin PF05042.13 CRG88229.1 - 0.38 10.7 1.1 71 3.3 0.0 3.8 2 1 0 3 3 3 0 Caleosin related protein SRF-TF PF00319.18 CRG88230.1 - 2.7e-24 84.4 0.1 4.2e-24 83.8 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) DUF1708 PF08101.11 CRG88231.1 - 5.4e-177 589.3 0.0 8.5e-177 588.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) VMA21 PF09446.10 CRG88232.1 - 4.3e-16 58.8 8.2 5.3e-16 58.5 8.2 1.1 1 0 0 1 1 1 1 VMA21-like domain TMEM100 PF16311.5 CRG88232.1 - 0.021 14.4 0.2 0.025 14.1 0.2 1.4 1 1 0 1 1 1 0 Transmembrane protein 100 DUF4282 PF14110.6 CRG88232.1 - 1.1 10.0 5.9 1.4 9.7 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) CBS PF00571.28 CRG88233.1 - 1e-06 29.1 0.0 2.1 8.9 0.0 3.3 3 1 0 3 3 3 3 CBS domain Tom6 PF17112.5 CRG88234.1 - 0.0042 16.5 0.2 0.0078 15.7 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal zf-CCHC_6 PF15288.6 CRG88235.1 - 0.00096 18.9 2.5 0.00096 18.9 2.5 1.8 2 0 0 2 2 2 1 Zinc knuckle GIY-YIG PF01541.24 CRG88235.1 - 0.047 14.0 0.0 0.16 12.2 0.0 1.9 1 0 0 1 1 1 0 GIY-YIG catalytic domain zf-CCHC PF00098.23 CRG88235.1 - 0.11 12.6 3.5 0.35 11.0 3.5 1.9 1 0 0 1 1 1 0 Zinc knuckle Myb_DNA-bind_6 PF13921.6 CRG88236.1 - 0.094 13.0 1.6 0.2 11.9 1.6 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain APH PF01636.23 CRG88237.1 - 1.1e-16 61.5 0.0 1.6e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG88237.1 - 0.00024 20.7 0.0 0.00038 20.1 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 CRG88237.1 - 0.0013 18.1 0.0 0.43 9.9 0.0 2.1 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 CRG88237.1 - 0.0085 15.7 0.0 0.084 12.5 0.0 2.0 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.17 CRG88237.1 - 0.074 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase BCS1_N PF08740.11 CRG88239.1 - 8.1e-39 133.5 0.2 1.3e-38 132.9 0.2 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CRG88239.1 - 5.3e-18 65.7 0.0 1.2e-17 64.5 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CRG88239.1 - 0.0035 17.1 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CRG88239.1 - 0.024 15.0 0.0 0.064 13.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Spec3 PF15795.5 CRG88239.1 - 0.041 14.4 0.1 0.072 13.6 0.1 1.3 1 0 0 1 1 1 0 Ectodermal ciliogenesis protein AAA_11 PF13086.6 CRG88239.1 - 0.092 12.5 0.1 0.41 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CRG88239.1 - 0.12 12.5 0.0 0.31 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CRG88239.1 - 0.13 11.8 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain TMEM52 PF14979.6 CRG88240.1 - 0.026 14.5 0.1 3 7.8 0.0 2.6 2 0 0 2 2 2 0 Transmembrane 52 Pkinase PF00069.25 CRG88241.1 - 2.4e-07 30.4 0.0 3.7e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88241.1 - 0.00065 19.1 0.0 0.0012 18.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase DUF3723 PF12520.8 CRG88242.1 - 5.8e-188 625.7 0.0 7.1e-188 625.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) BTB PF00651.31 CRG88242.1 - 5.9e-05 23.3 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Thymidylat_synt PF00303.19 CRG88242.1 - 0.14 11.3 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Thymidylate synthase Pkinase PF00069.25 CRG88243.1 - 6.7e-05 22.4 0.0 8.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88243.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase E1-E2_ATPase PF00122.20 CRG88244.1 - 1.3e-45 155.1 2.8 1.3e-45 155.1 2.8 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CRG88244.1 - 2.2e-20 73.9 0.0 4.1e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CRG88244.1 - 4.8e-05 23.7 2.0 5.4e-05 23.6 0.2 2.0 2 0 0 2 2 2 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CRG88244.1 - 0.00055 19.8 0.1 0.0052 16.5 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SCAMP PF04144.13 CRG88244.1 - 2.5 8.4 7.9 0.43 10.9 3.5 1.9 2 0 0 2 2 2 0 SCAMP family Cation_efflux PF01545.21 CRG88245.1 - 1.9e-51 174.6 8.8 2.6e-51 174.2 8.8 1.2 1 0 0 1 1 1 1 Cation efflux family BPD_transp_2 PF02653.16 CRG88245.1 - 0.027 13.6 0.5 0.027 13.6 0.5 1.8 2 0 0 2 2 2 0 Branched-chain amino acid transport system / permease component PAP2_3 PF14378.6 CRG88245.1 - 0.12 12.0 2.6 2.2 7.9 0.1 2.4 2 0 0 2 2 2 0 PAP2 superfamily DUF1361 PF07099.11 CRG88245.1 - 0.29 11.1 2.2 0.36 10.8 0.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1361) Nramp PF01566.18 CRG88246.1 - 3.4e-93 312.5 22.1 3.4e-93 312.5 22.1 1.7 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein E1-E2_ATPase PF00122.20 CRG88247.1 - 5.8e-46 156.3 0.1 9.6e-45 152.3 0.0 2.7 2 1 1 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 CRG88247.1 - 2.1e-34 119.7 0.2 3.7e-34 118.9 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CRG88247.1 - 8.4e-27 93.4 0.1 1.4e-11 44.7 0.1 3.8 3 0 0 3 3 3 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CRG88247.1 - 4.4e-05 23.4 0.0 0.00014 21.7 0.0 1.9 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CRG88247.1 - 0.0081 16.6 0.0 0.038 14.4 0.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ACT PF01842.25 CRG88247.1 - 0.026 14.3 0.1 0.13 12.1 0.1 2.3 1 0 0 1 1 1 0 ACT domain Cu-oxidase_2 PF07731.14 CRG88248.1 - 2.9e-43 146.9 5.3 1.4e-35 122.0 4.4 3.9 2 2 1 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG88248.1 - 3.3e-42 143.2 3.0 3e-40 136.9 0.0 4.1 5 0 0 5 5 5 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG88248.1 - 7.9e-20 71.6 0.1 4.9e-13 49.5 0.1 3.3 2 1 1 3 3 3 2 Multicopper oxidase DUF4882 PF16223.5 CRG88248.1 - 0.06 12.6 0.1 0.24 10.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4882) E1-E2_ATPase PF00122.20 CRG88249.1 - 1.1e-46 158.6 0.0 4.3e-46 156.7 0.0 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CRG88249.1 - 1e-31 110.9 0.2 1.9e-31 110.0 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 CRG88249.1 - 1.7e-27 95.6 0.6 1.4e-10 41.4 0.0 4.7 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase_3 PF08282.12 CRG88249.1 - 9.3e-05 22.3 0.0 0.00021 21.1 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SNAD4 PF18750.1 CRG88249.1 - 0.016 15.3 1.3 0.94 9.6 0.0 3.7 4 0 0 4 4 4 0 Secreted Novel AID/APOBEC-like Deaminase 4 Fer2_BFD PF04324.15 CRG88249.1 - 1.6 9.1 4.5 20 5.6 0.0 3.7 4 0 0 4 4 4 0 BFD-like [2Fe-2S] binding domain DUF3435 PF11917.8 CRG88250.1 - 3.1e-149 497.5 0.2 4.3e-149 497.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) RRN3 PF05327.11 CRG88250.1 - 1.8 7.0 7.1 0.12 10.9 2.0 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.13 CRG88250.1 - 9.8 6.2 24.8 0.48 10.5 10.2 2.2 2 0 0 2 2 2 0 YL1 nuclear protein DUF3602 PF12223.8 CRG88251.1 - 2.9e-20 72.6 7.2 2e-17 63.5 0.8 3.1 2 1 1 3 3 3 3 Protein of unknown function (DUF3602) DUF2406 PF10295.9 CRG88252.1 - 7.4e-27 93.8 2.1 1.1e-26 93.2 0.2 2.3 2 0 0 2 2 2 1 Uncharacterised protein (DUF2406) Ribosomal_L35Ae PF01247.18 CRG88253.1 - 6.5e-43 144.8 0.2 7.3e-43 144.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 CRG88253.1 - 0.0003 20.9 0.1 0.19 12.0 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain DUF2080 PF09853.9 CRG88253.1 - 0.12 12.2 1.0 1 9.1 0.2 2.2 1 1 1 2 2 2 0 Putative transposon-encoded protein (DUF2080) G6PD_C PF02781.16 CRG88254.1 - 1.4e-114 382.2 0.0 2.4e-114 381.4 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 CRG88254.1 - 3.2e-61 207.0 0.1 6.7e-61 206.0 0.1 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain MFS_2 PF13347.6 CRG88255.1 - 9.3e-15 54.1 10.9 9.3e-15 54.1 10.9 2.1 2 0 0 2 2 2 1 MFS/sugar transport protein MFS_1_like PF12832.7 CRG88255.1 - 1.8e-05 23.8 4.2 1.8e-05 23.8 4.2 1.6 2 0 0 2 2 2 1 MFS_1 like family BT1 PF03092.16 CRG88255.1 - 0.084 11.1 4.6 0.13 10.4 4.6 1.2 1 0 0 1 1 1 0 BT1 family DUF2976 PF11190.8 CRG88255.1 - 0.21 11.4 1.4 2.5 8.0 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) TPR_10 PF13374.6 CRG88256.1 - 1.5e-50 167.7 27.0 7.2e-09 35.2 0.1 8.6 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 CRG88256.1 - 1.1e-41 141.0 23.1 5.9e-11 42.5 0.8 5.5 2 1 2 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88256.1 - 9.8e-18 62.8 12.6 0.27 11.6 0.2 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88256.1 - 2.2e-14 53.7 27.4 0.011 16.2 1.1 8.0 2 1 6 8 8 8 5 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG88256.1 - 4.4e-14 52.5 11.9 0.074 13.3 0.4 6.7 1 1 5 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 CRG88256.1 - 3.3e-11 43.0 18.0 0.32 11.9 0.1 8.6 4 3 4 8 8 8 2 Tetratricopeptide repeat TPR_20 PF14561.6 CRG88256.1 - 3.9e-11 43.1 21.0 0.095 13.0 0.3 6.9 1 1 5 6 6 6 5 Tetratricopeptide repeat NB-ARC PF00931.22 CRG88256.1 - 2.1e-10 40.2 0.0 4.7e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain TPR_2 PF07719.17 CRG88256.1 - 1.4e-09 37.3 14.9 1.3 9.3 0.0 8.2 8 0 0 8 8 8 2 Tetratricopeptide repeat PPR PF01535.20 CRG88256.1 - 5.6e-09 35.7 0.0 12 6.4 0.0 6.5 6 0 0 6 6 6 0 PPR repeat TPR_7 PF13176.6 CRG88256.1 - 7.4e-09 35.0 12.2 0.27 11.3 0.0 7.0 8 0 0 8 8 6 3 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 CRG88256.1 - 1.3e-08 34.4 2.3 9.1e-08 31.6 2.3 2.3 1 1 0 1 1 1 1 Phosphorylase superfamily TPR_6 PF13174.6 CRG88256.1 - 1.7e-08 34.5 6.5 1.4 9.7 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88256.1 - 2.2e-06 27.7 18.6 0.33 11.4 0.2 7.7 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG88256.1 - 0.00047 19.9 8.3 7.7 6.5 0.0 6.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_4 PF07721.14 CRG88256.1 - 0.0018 18.7 20.8 7.5 7.5 0.2 7.5 7 0 0 7 7 7 1 Tetratricopeptide repeat AAA_16 PF13191.6 CRG88256.1 - 0.017 15.5 0.0 0.017 15.5 0.0 3.4 4 2 1 5 5 3 0 AAA ATPase domain TPR_16 PF13432.6 CRG88256.1 - 0.061 14.0 21.4 5.8 7.7 3.0 6.7 4 1 3 7 7 7 0 Tetratricopeptide repeat F-box PF00646.33 CRG88259.1 - 0.008 16.0 0.3 0.015 15.2 0.3 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG88259.1 - 0.11 12.4 0.3 0.22 11.4 0.3 1.5 1 0 0 1 1 1 0 F-box-like F-box-like PF12937.7 CRG88260.1 - 7.4e-05 22.6 2.3 0.00011 22.0 0.7 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CRG88260.1 - 9.9e-05 22.1 1.8 0.00022 21.0 1.8 1.6 1 0 0 1 1 1 1 F-box domain NBP1 PF08537.10 CRG88260.1 - 0.031 13.7 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 F-box_4 PF15966.5 CRG88260.1 - 0.11 12.3 1.0 2.1 8.3 0.1 2.8 2 1 0 3 3 3 0 F-box Glyco_hydro_31 PF01055.26 CRG88261.1 - 9e-144 479.9 7.3 1.3e-143 479.4 7.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG88261.1 - 6.9e-28 97.2 0.1 1.3e-27 96.2 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG88261.1 - 6e-06 26.5 0.4 6e-06 26.5 0.4 3.0 3 0 0 3 3 3 1 Galactose mutarotase-like AAA_22 PF13401.6 CRG88263.1 - 4.6e-05 23.7 0.0 0.0001 22.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG88263.1 - 0.00069 20.0 0.0 0.0022 18.4 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 CRG88263.1 - 0.0036 16.8 0.0 0.0074 15.8 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 CRG88263.1 - 0.017 15.7 0.0 0.053 14.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CRG88263.1 - 0.033 14.2 0.0 0.058 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 CRG88263.1 - 0.037 13.7 0.0 0.06 13.0 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase ATPase_2 PF01637.18 CRG88263.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 CRG88263.1 - 0.061 12.4 0.0 0.098 11.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_29 PF13555.6 CRG88263.1 - 0.092 12.5 0.2 0.2 11.4 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CRG88263.1 - 0.16 12.4 0.0 0.36 11.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DiS_P_DiS PF06750.13 CRG88263.1 - 0.16 12.1 0.2 22 5.2 0.3 2.5 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Sigma54_activat PF00158.26 CRG88263.1 - 0.19 11.4 0.0 0.32 10.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 CRG88263.1 - 0.2 11.8 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 CRG88263.1 - 0.2 10.4 0.0 1 8.1 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain AAA_10 PF12846.7 CRG88263.1 - 0.22 10.4 0.0 0.37 9.7 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain DUF2075 PF09848.9 CRG88263.1 - 0.22 10.7 0.0 0.54 9.4 0.0 1.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) ATPase PF06745.13 CRG88263.1 - 0.24 10.7 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 KaiC DJ-1_PfpI PF01965.24 CRG88264.1 - 1.2e-12 48.0 0.0 2.8e-12 46.8 0.0 1.6 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 CRG88264.1 - 7.3e-09 35.6 0.0 2.3e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 ThiJ/PfpI family-like SNF2_N PF00176.23 CRG88265.1 - 1.5e-52 178.5 0.1 2.6e-52 177.7 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG88265.1 - 2.2e-18 66.6 0.0 2.3e-17 63.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88265.1 - 1.7e-10 41.1 0.0 3.8e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG88265.1 - 7.5e-05 22.1 0.1 0.00015 21.1 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HIGH_NTase1_ass PF16581.5 CRG88265.1 - 0.032 14.2 0.1 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 Cytidyltransferase-related C-terminal region COesterase PF00135.28 CRG88266.1 - 1.5e-93 314.5 0.0 2e-93 314.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG88266.1 - 3.5e-06 27.0 0.0 1.2e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold FTZ PF03867.14 CRG88266.1 - 0.11 12.0 0.1 0.11 12.0 0.1 2.0 2 0 0 2 2 2 0 Fushi tarazu (FTZ), N-terminal region Dus PF01207.17 CRG88267.1 - 1.2e-45 155.9 0.0 4.1e-45 154.2 0.0 1.8 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) MRP_L53 PF10780.9 CRG88268.1 - 4.8e-16 58.7 0.1 6.8e-16 58.2 0.1 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Sulfotransfer_3 PF13469.6 CRG88269.1 - 0.0063 16.9 0.1 0.025 14.9 0.0 1.9 1 1 1 2 2 2 1 Sulfotransferase family Arylsulfotran_2 PF14269.6 CRG88270.1 - 1.9e-64 217.9 0.2 2.4e-64 217.6 0.2 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Sec20 PF03908.13 CRG88271.1 - 1.3e-16 60.2 3.8 1.6e-16 60.0 1.6 2.2 2 0 0 2 2 2 1 Sec20 ArAE_2 PF10334.9 CRG88271.1 - 0.061 13.1 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 DUF3510 PF12022.8 CRG88271.1 - 0.07 13.5 2.5 0.19 12.1 2.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3510) FapA PF03961.13 CRG88271.1 - 0.11 11.0 3.8 0.076 11.6 2.2 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin PF02996.17 CRG88271.1 - 0.12 12.3 2.9 1.9 8.4 0.2 2.5 2 0 0 2 2 2 0 Prefoldin subunit NPV_P10 PF05531.12 CRG88271.1 - 0.14 12.6 1.4 6.6 7.3 0.1 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Syntaxin-6_N PF09177.11 CRG88271.1 - 0.35 11.4 9.6 0.15 12.6 0.4 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Rep_fac_C PF08542.11 CRG88272.1 - 7.7e-20 71.1 0.0 1.7e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CRG88272.1 - 1.4e-14 54.7 0.0 3.9e-14 53.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CRG88272.1 - 1.5e-12 47.6 0.1 6.1e-11 42.4 0.0 2.7 2 1 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CRG88272.1 - 8e-09 35.7 0.0 2.7e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 CRG88272.1 - 3.4e-05 23.6 0.0 0.00012 21.9 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 CRG88272.1 - 4.1e-05 24.0 0.4 0.00046 20.6 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain Glyco_hydro_75 PF07335.11 CRG88272.1 - 4.9e-05 23.7 0.0 0.00013 22.3 0.0 1.8 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 AAA_22 PF13401.6 CRG88272.1 - 6e-05 23.3 0.0 0.00026 21.3 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 CRG88272.1 - 0.0001 22.5 0.5 0.00036 20.8 0.1 2.2 2 0 0 2 2 1 1 AAA C-terminal domain AAA_11 PF13086.6 CRG88272.1 - 0.00014 21.8 0.1 0.00041 20.2 0.0 1.7 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CRG88272.1 - 0.00041 19.8 0.0 0.016 14.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 CRG88272.1 - 0.00056 19.3 0.0 0.00095 18.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 CRG88272.1 - 0.0019 17.9 0.0 0.0055 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CRG88272.1 - 0.0027 17.7 0.0 0.0061 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG88272.1 - 0.0061 16.9 0.0 0.037 14.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CRG88272.1 - 0.0086 16.1 0.0 0.036 14.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 CRG88272.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region DNA_pol3_delta PF06144.13 CRG88272.1 - 0.014 15.1 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit DUF815 PF05673.13 CRG88272.1 - 0.017 14.3 0.0 0.027 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 CRG88272.1 - 0.028 14.7 0.0 0.085 13.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain ResIII PF04851.15 CRG88272.1 - 0.043 13.8 0.1 0.54 10.2 0.0 2.3 2 1 1 3 3 2 0 Type III restriction enzyme, res subunit AAA_3 PF07726.11 CRG88272.1 - 0.053 13.4 0.0 0.7 9.8 0.0 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 CRG88272.1 - 0.08 12.7 0.1 0.66 9.7 0.0 2.3 1 1 0 2 2 2 0 DEAD/DEAH box helicase AAA_18 PF13238.6 CRG88272.1 - 0.082 13.4 0.0 0.25 11.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain FAD_binding_2 PF00890.24 CRG88273.1 - 3e-125 418.6 3.2 5.2e-125 417.8 3.2 1.4 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 CRG88273.1 - 1.3e-43 148.0 1.4 3.4e-43 146.7 1.4 1.7 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyridoxal_deC PF00282.19 CRG88273.1 - 6.1e-16 58.1 0.0 1.7e-09 36.9 0.0 3.1 3 0 0 3 3 3 2 Pyridoxal-dependent decarboxylase conserved domain Pyr_redox_2 PF07992.14 CRG88273.1 - 0.00015 21.1 2.0 0.0051 16.1 0.9 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG88273.1 - 0.00027 20.1 0.6 0.052 12.6 1.2 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A F-box PF00646.33 CRG88273.1 - 0.0031 17.3 0.6 0.0084 16.0 0.6 1.7 1 0 0 1 1 1 1 F-box domain Thi4 PF01946.17 CRG88273.1 - 0.0031 16.8 0.3 0.18 11.0 0.1 2.3 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CRG88273.1 - 0.006 15.9 0.4 0.028 13.7 0.2 2.2 2 0 0 2 2 2 1 FAD binding domain Beta_elim_lyase PF01212.21 CRG88273.1 - 0.017 14.4 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase DAO PF01266.24 CRG88273.1 - 0.21 11.1 3.3 0.14 11.7 1.0 1.9 2 1 0 2 2 2 0 FAD dependent oxidoreductase AAA PF00004.29 CRG88274.1 - 5.9e-41 140.0 0.0 1.1e-40 139.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG88274.1 - 7.9e-06 25.6 0.1 2e-05 24.3 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 CRG88274.1 - 6.8e-05 23.2 0.0 0.0059 16.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 CRG88274.1 - 0.00011 22.2 0.0 0.00043 20.3 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 CRG88274.1 - 0.00021 21.4 0.0 0.00069 19.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CRG88274.1 - 0.00034 21.0 0.1 0.008 16.6 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 CRG88274.1 - 0.0019 17.4 0.0 0.0035 16.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 CRG88274.1 - 0.0081 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 CRG88274.1 - 0.014 15.6 0.1 0.063 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CRG88274.1 - 0.03 13.8 0.0 0.097 12.2 0.0 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region DUF4164 PF13747.6 CRG88274.1 - 0.047 14.0 0.1 0.11 12.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) AAA_33 PF13671.6 CRG88274.1 - 0.048 13.8 0.0 0.094 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CRG88274.1 - 0.061 13.7 0.0 0.16 12.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 CRG88274.1 - 0.079 12.7 0.1 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CRG88274.1 - 0.084 12.7 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CRG88274.1 - 0.096 12.4 0.0 0.24 11.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CRG88274.1 - 0.14 12.7 0.0 0.48 11.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CRG88274.1 - 0.14 12.2 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CRG88274.1 - 0.16 11.9 0.4 11 5.9 0.0 2.7 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea Cpn60_TCP1 PF00118.24 CRG88275.1 - 5.4e-149 497.0 11.7 6.1e-149 496.8 11.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DPPIV_N PF00930.21 CRG88276.1 - 5.8e-115 383.8 0.5 7.6e-115 383.4 0.5 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 CRG88276.1 - 3.2e-55 186.9 4.8 5.1e-55 186.2 4.8 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 CRG88276.1 - 2.4e-05 24.1 4.3 0.00023 20.9 2.1 2.3 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 CRG88276.1 - 0.00054 19.7 0.3 0.0012 18.5 0.3 1.5 1 0 0 1 1 1 1 Putative esterase COesterase PF00135.28 CRG88276.1 - 0.0023 16.9 0.0 0.0037 16.2 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family DLH PF01738.18 CRG88276.1 - 0.057 13.0 0.0 0.23 11.0 0.0 1.8 1 1 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CRG88276.1 - 0.13 12.1 0.1 16 5.2 0.0 2.2 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Questin_oxidase PF14027.6 CRG88277.1 - 2.2e-67 228.0 0.1 3.3e-67 227.5 0.1 1.1 1 0 0 1 1 1 1 Questin oxidase-like Epimerase PF01370.21 CRG88278.1 - 1.3e-34 119.7 0.0 5.2e-34 117.8 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG88278.1 - 6.1e-31 108.0 0.0 1.9e-30 106.4 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CRG88278.1 - 6.7e-07 28.7 0.0 7.6e-05 22.0 0.0 2.6 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CRG88278.1 - 2.1e-06 27.1 0.0 5.2e-06 25.8 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 CRG88278.1 - 4.2e-06 26.0 0.1 0.00026 20.1 0.1 2.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 CRG88278.1 - 0.00015 21.7 0.0 0.00028 20.9 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CRG88278.1 - 0.0016 17.9 0.0 0.0027 17.2 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Pyr_redox_2 PF07992.14 CRG88278.1 - 0.013 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CRG88278.1 - 0.018 14.7 0.0 0.031 13.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RmlD_sub_bind PF04321.17 CRG88278.1 - 0.093 11.8 0.0 0.51 9.4 0.0 2.2 1 1 0 1 1 1 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 CRG88278.1 - 0.18 12.0 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AAA_24 PF13479.6 CRG88278.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Spherulin4 PF12138.8 CRG88279.1 - 3e-72 243.2 0.1 3.3e-72 243.0 0.1 1.0 1 0 0 1 1 1 1 Spherulation-specific family 4 Lipase_GDSL PF00657.22 CRG88279.1 - 0.093 12.7 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase DUF853 PF05872.12 CRG88279.1 - 0.19 10.3 0.0 0.26 9.8 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Glyco_hydro_114 PF03537.13 CRG88280.1 - 3.1e-89 298.3 1.2 4e-89 297.9 1.2 1.1 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 DUF4755 PF15947.5 CRG88280.1 - 0.034 14.1 0.1 0.062 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4755) Polysacc_deac_1 PF01522.21 CRG88281.1 - 0.06 13.3 0.2 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide deacetylase Bile_Hydr_Trans PF04775.14 CRG88281.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA thioester hydrolase/BAAT N-terminal region Glycos_transf_1 PF00534.20 CRG88282.1 - 2e-13 50.2 0.0 3.8e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG88282.1 - 7.5e-12 45.8 0.0 1.6e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Peptidase_S8 PF00082.22 CRG88283.1 - 1.5e-46 159.0 0.0 4.4e-46 157.5 0.0 1.7 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 CRG88283.1 - 1.3e-16 61.4 0.3 2.3e-16 60.5 0.3 1.5 1 0 0 1 1 1 1 Fn3-like domain RPT PF13446.6 CRG88283.1 - 0.056 13.4 0.0 1 9.3 0.0 2.3 2 0 0 2 2 2 0 A repeated domain in UCH-protein HECT_2 PF09814.9 CRG88284.1 - 7.3e-111 370.7 0.0 8.8e-111 370.4 0.0 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Yippee-Mis18 PF03226.14 CRG88284.1 - 0.12 12.5 0.0 18 5.6 0.0 2.7 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TauD PF02668.16 CRG88285.1 - 1.3e-53 182.5 2.1 1.9e-53 182.0 2.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CRG88286.1 - 1.2e-26 93.5 19.3 5.5e-26 91.3 18.7 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF4519 PF15012.6 CRG88286.1 - 2.5 8.3 3.8 14 5.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Cupin_1 PF00190.22 CRG88287.1 - 0.13 11.9 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Cupin PI-PLC-X PF00388.19 CRG88288.1 - 1.2e-61 206.6 0.0 2e-61 205.9 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CRG88288.1 - 1.7e-41 141.1 0.5 3.1e-41 140.3 0.5 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 CRG88288.1 - 0.00013 22.2 0.0 0.00093 19.4 0.0 2.3 2 1 0 2 2 2 1 C2 domain V-SNARE PF05008.15 CRG88288.1 - 0.02 15.3 0.1 0.06 13.7 0.1 1.8 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus GST_N_3 PF13417.6 CRG88289.1 - 1.4e-07 31.8 0.0 3.9e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG88289.1 - 2.2e-06 27.6 0.0 4.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG88289.1 - 4.5e-06 26.9 0.0 1e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG88289.1 - 0.00061 20.0 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG88289.1 - 0.0013 18.9 0.0 0.0033 17.6 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Ribosomal_L37 PF08561.10 CRG88290.1 - 5.3e-44 149.6 0.8 6.9e-44 149.2 0.8 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 Transposase_22 PF02994.14 CRG88290.1 - 0.027 14.7 0.3 0.041 14.1 0.3 1.3 1 0 0 1 1 1 0 L1 transposable element RBD-like domain adh_short PF00106.25 CRG88291.1 - 5.6e-20 71.6 4.9 3.2e-17 62.6 3.9 3.1 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88291.1 - 1e-08 35.1 4.4 1.1e-06 28.5 2.3 3.0 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88291.1 - 2.5e-05 24.3 0.4 4.2e-05 23.5 0.4 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG88291.1 - 0.069 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AA_permease_2 PF13520.6 CRG88292.1 - 1.2e-52 179.2 56.0 1.6e-52 178.8 56.0 1.1 1 0 0 1 1 1 1 Amino acid permease AAA PF00004.29 CRG88292.1 - 1.1e-48 165.0 0.0 6.2e-43 146.4 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AA_permease PF00324.21 CRG88292.1 - 7.8e-19 67.6 47.0 1.1e-18 67.1 47.0 1.1 1 0 0 1 1 1 1 Amino acid permease AAA_lid_3 PF17862.1 CRG88292.1 - 3e-07 30.1 4.0 0.0034 17.2 0.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CRG88292.1 - 0.00016 22.1 0.4 0.034 14.5 0.0 3.5 3 1 0 4 4 2 1 AAA ATPase domain RuvB_N PF05496.12 CRG88292.1 - 0.00021 21.1 0.0 0.00061 19.6 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CRG88292.1 - 0.00081 19.7 0.0 0.023 15.1 0.0 2.9 3 0 0 3 3 2 1 RNA helicase Parvo_NS1 PF01057.17 CRG88292.1 - 0.00082 18.6 0.0 0.0014 17.8 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_2 PF07724.14 CRG88292.1 - 0.006 16.7 0.0 0.013 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 CRG88292.1 - 0.0063 16.1 0.2 0.067 12.8 0.0 2.7 3 1 0 3 3 3 1 AAA domain TIP49 PF06068.13 CRG88292.1 - 0.0093 15.2 0.0 0.017 14.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 CRG88292.1 - 0.012 15.8 0.0 0.64 10.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain AAA_22 PF13401.6 CRG88292.1 - 0.012 15.8 0.0 0.065 13.5 0.0 2.2 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 CRG88292.1 - 0.013 15.2 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 CRG88292.1 - 0.036 13.4 0.1 0.076 12.4 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 CRG88292.1 - 0.046 13.1 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_5 PF07728.14 CRG88292.1 - 0.062 13.3 0.0 0.19 11.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CRG88292.1 - 0.062 13.9 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CRG88292.1 - 0.063 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 CRG88292.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 CRG88292.1 - 0.12 11.8 0.0 0.29 10.6 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 CRG88292.1 - 0.19 12.0 0.0 0.45 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain Abhydrolase_1 PF00561.20 CRG88294.1 - 4.3e-07 29.8 0.0 7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG88294.1 - 4.2e-05 24.3 0.0 6.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG88294.1 - 0.0011 18.2 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CRG88294.1 - 0.0019 16.9 0.0 0.0026 16.5 0.0 1.3 1 0 0 1 1 1 1 Ndr family zf-C2H2 PF00096.26 CRG88295.1 - 0.0012 19.2 6.6 0.0012 19.2 6.6 3.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG88295.1 - 0.0076 17.0 5.6 0.0076 17.0 5.6 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 CRG88295.1 - 0.032 14.0 20.0 0.025 14.3 4.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF2894 PF11445.8 CRG88295.1 - 0.37 11.2 3.3 0.47 10.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) zf-C2H2_6 PF13912.6 CRG88295.1 - 0.46 10.5 3.4 1 9.5 3.4 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG88295.1 - 1.1 9.9 14.2 7.9 7.1 0.4 3.8 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CRG88295.1 - 2.2 8.7 8.5 1.2 9.5 5.4 2.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Trypan_PARP PF05887.11 CRG88296.1 - 0.0044 17.0 9.1 0.0071 16.3 9.1 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) BTB PF00651.31 CRG88296.1 - 0.015 15.6 0.0 0.073 13.3 0.0 2.0 2 1 0 2 2 2 0 BTB/POZ domain ketoacyl-synt PF00109.26 CRG88297.1 - 2.8e-63 213.9 1.4 4.6e-63 213.1 0.3 2.0 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CRG88297.1 - 1.1e-35 122.2 0.1 2.7e-35 121.0 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain HTH_51 PF18558.1 CRG88297.1 - 2.7e-25 88.1 0.0 3.2e-24 84.6 0.0 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain Methyltransf_12 PF08242.12 CRG88297.1 - 7.4e-19 68.3 0.0 2.3e-18 66.8 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Acyl_transf_1 PF00698.21 CRG88297.1 - 1.6e-18 67.3 0.0 2.6e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Methyltransf_23 PF13489.6 CRG88297.1 - 2.3e-13 50.3 0.0 2.5e-12 46.9 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG88297.1 - 1.1e-11 45.3 0.0 8.9e-11 42.4 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG88297.1 - 4.4e-10 40.1 0.0 1.3e-09 38.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88297.1 - 4.1e-09 36.4 0.0 1.2e-08 34.9 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CRG88297.1 - 2.7e-08 34.1 2.1 9.1e-08 32.4 1.2 2.3 2 0 0 2 2 2 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CRG88297.1 - 3.2e-05 24.4 0.0 7.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Ubie_methyltran PF01209.18 CRG88297.1 - 9.7e-05 21.8 0.0 0.0002 20.8 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 CRG88297.1 - 0.00013 21.8 0.0 0.00034 20.4 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF938) Thiolase_N PF00108.23 CRG88297.1 - 0.26 10.6 1.3 0.38 10.1 0.3 1.7 2 0 0 2 2 2 0 Thiolase, N-terminal domain Scytalone_dh PF02982.14 CRG88298.1 - 5.2e-49 166.1 0.3 6.6e-49 165.8 0.3 1.0 1 0 0 1 1 1 1 Scytalone dehydratase SnoaL_4 PF13577.6 CRG88298.1 - 2.9e-10 40.4 0.6 3.7e-10 40.0 0.6 1.1 1 0 0 1 1 1 1 SnoaL-like domain LPD23 PF18838.1 CRG88298.1 - 0.021 14.5 0.5 0.052 13.3 0.5 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 SnoaL_3 PF13474.6 CRG88298.1 - 0.094 13.0 0.3 0.28 11.5 0.1 1.8 2 0 0 2 2 2 0 SnoaL-like domain Methyltransf_2 PF00891.18 CRG88299.1 - 1.8e-28 99.3 0.0 2.6e-28 98.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CRG88299.1 - 9.5e-06 26.2 0.0 2.3e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG88299.1 - 0.00013 21.4 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG88299.1 - 0.014 16.2 0.0 0.029 15.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CRG88299.1 - 0.065 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 CRG88299.1 - 0.075 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF996 PF06195.13 CRG88300.1 - 2.6 8.3 11.3 0.5 10.6 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF996) NmrA PF05368.13 CRG88301.1 - 4.6e-28 98.4 0.0 1.1e-27 97.1 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG88301.1 - 3.9e-08 33.4 0.0 5.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG88301.1 - 0.00073 19.1 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CRG88301.1 - 0.021 15.1 0.1 0.057 13.7 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain 3Beta_HSD PF01073.19 CRG88301.1 - 0.098 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family AA_permease_2 PF13520.6 CRG88302.1 - 2.5e-54 184.7 45.8 3.2e-54 184.4 45.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG88302.1 - 2e-21 76.2 36.8 2.7e-21 75.7 36.8 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1182 PF06681.13 CRG88302.1 - 0.0093 15.6 2.7 0.024 14.2 2.7 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1182) DUF3493 PF11998.8 CRG88302.1 - 0.058 13.6 0.0 0.24 11.6 0.0 2.1 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 ATP_synth_reg PF14960.6 CRG88302.1 - 5.2 6.6 6.0 3.9 7.0 0.1 3.6 4 0 0 4 4 4 0 ATP synthase regulation Cu_amine_oxid PF01179.20 CRG88303.1 - 5.5e-154 513.0 0.0 6.8e-154 512.7 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 CRG88303.1 - 7.9e-18 64.7 0.0 1.9e-17 63.5 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 CRG88303.1 - 2e-09 37.5 0.0 3.6e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Aldedh PF00171.22 CRG88305.1 - 1.6e-186 620.3 0.1 1.8e-186 620.2 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CRG88305.1 - 0.0022 17.5 0.0 0.14 11.6 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) DUF3818 PF12825.7 CRG88306.1 - 8.2e-133 442.6 6.6 8.2e-133 442.6 6.6 2.2 3 0 0 3 3 3 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 CRG88306.1 - 5e-39 133.3 0.8 1.1e-38 132.2 0.8 1.5 1 0 0 1 1 1 1 PX-associated PX PF00787.24 CRG88306.1 - 3.6e-11 43.1 0.3 3.6e-11 43.1 0.3 2.8 3 1 0 3 3 3 1 PX domain MFS_1 PF07690.16 CRG88307.1 - 2.7e-44 151.5 41.5 2.7e-44 151.5 41.5 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88307.1 - 1.2e-13 50.8 24.1 3.1e-13 49.4 12.9 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter TRI12 PF06609.13 CRG88307.1 - 2.9e-07 29.3 17.8 4.3e-07 28.7 17.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Arylsulfotran_2 PF14269.6 CRG88308.1 - 1.1e-77 261.4 3.8 1.1e-77 261.4 3.8 1.4 2 0 0 2 2 2 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CRG88308.1 - 2.4e-21 76.1 3.0 3.3e-20 72.3 3.1 2.0 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Metallophos PF00149.28 CRG88309.1 - 1.4e-11 45.3 0.9 1.8e-11 44.9 0.9 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG88309.1 - 0.023 14.9 0.0 0.069 13.3 0.0 1.7 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain FAD_binding_3 PF01494.19 CRG88311.1 - 1.1e-10 41.3 0.2 2e-09 37.2 0.2 2.4 1 1 0 1 1 1 1 FAD binding domain MFS_1 PF07690.16 CRG88311.1 - 6.9e-08 31.8 30.5 6.9e-08 31.8 30.5 2.4 1 1 2 3 3 3 2 Major Facilitator Superfamily Pyr_redox_3 PF13738.6 CRG88311.1 - 0.0004 19.7 0.0 0.00062 19.1 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG88311.1 - 0.018 14.3 0.1 0.047 12.9 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG88311.1 - 0.12 11.0 0.1 0.2 10.3 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Ank_2 PF12796.7 CRG88312.1 - 6e-72 238.3 6.3 1.6e-11 44.6 0.2 6.7 2 2 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88312.1 - 3.7e-62 206.0 13.1 2.1e-12 47.3 0.1 8.5 6 2 2 8 8 8 8 Ankyrin repeats (many copies) Ank PF00023.30 CRG88312.1 - 8.1e-53 174.7 21.1 1.6e-05 25.1 0.0 13.6 13 0 0 13 13 13 11 Ankyrin repeat Ank_5 PF13857.6 CRG88312.1 - 1.7e-47 158.8 19.0 1.9e-08 34.4 0.0 11.0 3 3 7 11 11 11 11 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG88312.1 - 5.5e-46 149.2 13.0 0.00029 21.1 0.0 13.6 13 0 0 13 13 13 10 Ankyrin repeat Met_10 PF02475.16 CRG88313.1 - 3.4e-67 226.1 0.0 5.4e-67 225.4 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein RNA_pol_Rpb4 PF03874.16 CRG88314.1 - 2.1e-25 89.4 4.3 4e-25 88.5 4.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb4 Cut8 PF08559.10 CRG88314.1 - 0.18 11.4 5.7 0.32 10.6 5.7 1.7 1 1 0 1 1 1 0 Cut8, nuclear proteasome tether protein Fungal_trans PF04082.18 CRG88315.1 - 2.1e-21 76.2 1.5 2.9e-21 75.7 1.5 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88315.1 - 0.0023 18.0 10.1 0.0045 17.1 10.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Multi-haem_cyto PF13447.6 CRG88315.1 - 0.34 10.1 1.9 0.28 10.4 0.2 1.7 2 0 0 2 2 2 0 Seven times multi-haem cytochrome CxxCH AA_permease PF00324.21 CRG88316.1 - 1.1e-113 380.5 42.8 1.2e-113 380.3 42.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG88316.1 - 1.4e-28 99.9 50.0 2e-28 99.4 49.4 1.4 1 1 0 1 1 1 1 Amino acid permease PBP_N PF17093.5 CRG88316.1 - 0.48 10.7 1.4 9.2 6.5 0.3 2.6 2 0 0 2 2 2 0 Penicillin-binding protein N-terminus Abhydrolase_3 PF07859.13 CRG88317.1 - 1.2e-47 162.5 0.0 3.7e-47 160.9 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold DAO PF01266.24 CRG88317.1 - 9.2e-21 74.8 0.0 1.8e-20 73.9 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase COesterase PF00135.28 CRG88317.1 - 9.3e-06 24.8 0.0 1.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 CRG88317.1 - 0.053 13.0 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Fungal_trans PF04082.18 CRG88318.1 - 1.9e-19 69.8 0.0 2.8e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88318.1 - 0.0044 17.1 5.5 0.0079 16.3 5.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribosomal_S8e PF01201.22 CRG88319.1 - 4.1e-44 150.1 3.0 6.2e-44 149.5 3.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e Ribosomal_L21p PF00829.21 CRG88320.1 - 5.3e-10 39.5 0.0 8e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein CutA1 PF03091.15 CRG88320.1 - 0.18 11.7 0.3 0.34 10.8 0.3 1.4 1 0 0 1 1 1 0 CutA1 divalent ion tolerance protein Peptidase_M18 PF02127.15 CRG88321.1 - 4.6e-168 559.5 0.0 6.5e-168 559.0 0.0 1.2 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 CRG88321.1 - 0.0073 15.4 0.0 0.19 10.7 0.0 2.3 1 1 1 2 2 2 2 M42 glutamyl aminopeptidase WD40 PF00400.32 CRG88322.1 - 7.2e-26 89.9 8.5 5.3e-06 27.1 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88322.1 - 4.3e-15 55.8 5.4 9e-06 25.9 0.2 4.6 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG88322.1 - 1.5e-06 28.2 0.3 0.05 13.5 0.0 3.1 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CRG88322.1 - 0.047 12.6 0.0 0.15 11.0 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyco_hydro_32N PF00251.20 CRG88323.1 - 1.7e-67 228.2 0.7 2.4e-67 227.7 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 CRG88323.1 - 3.7e-17 62.8 0.1 7.6e-17 61.7 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal Sugar_tr PF00083.24 CRG88324.1 - 6.8e-125 417.5 21.2 7.9e-125 417.2 21.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88324.1 - 2.9e-21 75.8 28.6 2.9e-21 75.8 28.6 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily GDP_Man_Dehyd PF16363.5 CRG88324.1 - 0.15 11.5 0.0 0.23 10.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase CrgA PF06781.12 CRG88325.1 - 0.64 10.1 5.4 9.9 6.3 0.2 2.5 2 0 0 2 2 2 0 Cell division protein CrgA E3_binding PF02817.17 CRG88326.1 - 3.2e-10 40.2 0.2 1e-08 35.3 0.0 2.5 2 0 0 2 2 2 1 e3 binding domain NopRA1 PF16201.5 CRG88326.1 - 0.23 11.0 0.1 0.59 9.7 0.0 1.6 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 CcmD PF04995.14 CRG88327.1 - 0.07 13.2 2.3 0.093 12.8 0.8 1.9 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) SMC_N PF02463.19 CRG88328.1 - 1.4e-58 197.9 5.6 3.3e-57 193.5 5.6 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CRG88328.1 - 3.3e-30 104.8 0.0 1.1e-29 103.1 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CRG88328.1 - 4.1e-10 39.9 15.9 2.8e-05 24.1 0.1 4.2 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG88328.1 - 4.1e-08 32.9 0.0 9.6e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain zf-C4H2 PF10146.9 CRG88328.1 - 0.0032 17.8 11.2 0.0032 17.8 11.2 6.9 3 2 4 7 7 5 1 Zinc finger-containing protein SbcCD_C PF13558.6 CRG88328.1 - 0.0034 17.6 0.0 0.018 15.2 0.0 2.4 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit GFD1 PF17331.2 CRG88328.1 - 0.0074 16.4 3.6 0.03 14.5 3.6 2.2 1 0 0 1 1 1 1 GFD1 mRNA transport factor DUF1664 PF07889.12 CRG88328.1 - 0.008 16.2 1.8 0.008 16.2 1.8 7.9 4 2 3 8 8 8 4 Protein of unknown function (DUF1664) AAA_22 PF13401.6 CRG88328.1 - 0.012 15.9 5.8 11 6.3 0.0 4.9 4 1 0 4 4 4 0 AAA domain AcylCoA_dehyd_C PF12186.8 CRG88328.1 - 0.44 10.7 0.0 0.44 10.7 0.0 5.0 3 1 1 5 5 5 0 Acyl-CoA dehydrogenase C terminal ABC_tran PF00005.27 CRG88328.1 - 0.89 10.1 0.0 0.89 10.1 0.0 6.3 4 3 0 5 5 4 0 ABC transporter FPP PF05911.11 CRG88328.1 - 1.2 7.2 85.1 0.1 10.7 4.0 4.1 3 1 1 4 4 4 0 Filament-like plant protein, long coiled-coil Pox_A_type_inc PF04508.12 CRG88328.1 - 7.4 6.6 8.4 22 5.1 3.2 3.9 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF2841 PF11001.8 CRG88329.1 - 1.2e-50 170.7 0.2 1.9e-50 170.0 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) ADH_zinc_N PF00107.26 CRG88330.1 - 1e-10 41.7 0.1 1.9e-10 40.8 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88330.1 - 4.9e-07 29.6 0.0 1.5e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain E1-N PF14463.6 CRG88330.1 - 0.034 14.0 0.3 0.065 13.0 0.3 1.4 1 0 0 1 1 1 0 E1 N-terminal domain Sacchrp_dh_NADP PF03435.18 CRG88330.1 - 0.075 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DUF2838 PF10998.8 CRG88331.1 - 2.4e-41 140.5 8.6 2.4e-41 140.5 8.6 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Zn_clus PF00172.18 CRG88331.1 - 0.011 15.9 2.0 0.021 14.9 2.0 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3106 PF11304.8 CRG88331.1 - 3.8 8.0 8.7 0.87 10.1 4.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) LETM1 PF07766.13 CRG88332.1 - 2.8e-106 354.8 0.1 2.8e-106 354.8 0.1 1.6 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 CRG88332.1 - 9.6e-05 22.0 0.0 0.0033 17.1 0.0 3.0 3 0 0 3 3 3 1 SAP domain EVE PF01878.18 CRG88332.1 - 0.15 12.0 1.1 3.4 7.7 0.2 2.8 2 1 1 3 3 3 0 EVE domain NUDIX PF00293.28 CRG88333.1 - 7.5e-10 38.9 0.5 4.7e-09 36.4 0.0 2.3 1 1 0 2 2 2 1 NUDIX domain TPP_enzyme_N PF02776.18 CRG88335.1 - 2.2e-31 108.8 0.1 3.5e-31 108.1 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG88335.1 - 4.2e-16 59.1 0.1 1.6e-14 54.0 0.0 2.6 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG88335.1 - 4.9e-12 45.8 0.0 1.5e-11 44.2 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Ribosomal_S24e PF01282.19 CRG88335.1 - 0.1 12.6 0.0 19 5.3 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S24e NuA4 PF09340.10 CRG88336.1 - 9.4e-28 95.9 0.1 9.4e-28 95.9 0.1 1.7 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Tmemb_cc2 PF10267.9 CRG88336.1 - 6.7 5.7 8.6 0.21 10.7 1.0 1.9 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Ctr PF04145.15 CRG88337.1 - 1.1e-20 74.8 7.8 3.5e-20 73.1 7.8 1.7 1 1 0 1 1 1 1 Ctr copper transporter family DUF2897 PF11446.8 CRG88337.1 - 0.26 11.2 1.1 3 7.8 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) Cupin_8 PF13621.6 CRG88338.1 - 7e-14 52.2 0.2 2.3e-10 40.6 0.0 2.3 1 1 1 2 2 2 2 Cupin-like domain JmjC PF02373.22 CRG88338.1 - 1.6e-09 38.2 0.3 0.0022 18.4 0.1 2.4 2 0 0 2 2 2 2 JmjC domain, hydroxylase F-box-like PF12937.7 CRG88338.1 - 3e-07 30.2 0.2 6.3e-07 29.2 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG88338.1 - 8e-06 25.6 0.1 1.6e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 F-box domain Cupin_4 PF08007.12 CRG88338.1 - 0.029 13.8 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 Cupin superfamily protein DUF465 PF04325.13 CRG88338.1 - 0.16 12.0 1.9 0.52 10.4 1.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF465) DEAD PF00270.29 CRG88339.1 - 6.9e-45 153.0 1.6 1.2e-44 152.1 1.6 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG88339.1 - 3.2e-32 111.2 0.3 5e-31 107.3 0.1 2.6 2 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88339.1 - 5e-07 29.9 0.0 8.1e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CRG88339.1 - 3.6e-05 23.6 0.2 6.9e-05 22.7 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG88339.1 - 0.00047 20.5 0.3 0.0031 17.8 0.2 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG88339.1 - 0.0068 16.7 1.1 0.042 14.1 1.1 2.2 1 1 0 1 1 1 1 AAA domain CMS1 PF14617.6 CRG88339.1 - 0.0095 15.3 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 CRG88339.1 - 0.049 13.6 0.1 0.49 10.4 0.1 2.3 1 1 0 1 1 1 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 CRG88339.1 - 0.068 13.0 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 Helicase fragilysinNterm PF16376.5 CRG88339.1 - 0.072 12.8 0.1 0.29 10.9 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of fragilysin DUF1664 PF07889.12 CRG88340.1 - 0.00013 21.9 4.7 0.0049 16.9 1.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) DUF2120 PF09893.9 CRG88340.1 - 0.00051 20.2 0.6 0.00093 19.3 0.6 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2120) Laminin_I PF06008.14 CRG88340.1 - 0.001 18.9 2.8 0.002 17.9 2.8 1.5 1 0 0 1 1 1 1 Laminin Domain I YabA PF06156.13 CRG88340.1 - 0.0044 17.6 3.5 0.15 12.7 2.1 2.6 1 1 1 2 2 2 1 Initiation control protein YabA Filament PF00038.21 CRG88340.1 - 0.0066 16.1 2.4 0.015 14.9 2.4 1.6 1 0 0 1 1 1 1 Intermediate filament protein Cnn_1N PF07989.11 CRG88340.1 - 0.015 15.4 2.2 0.05 13.8 0.3 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 CRG88340.1 - 0.017 15.2 9.0 0.05 13.7 0.5 3.2 3 1 0 3 3 2 0 bZIP transcription factor DUF2203 PF09969.9 CRG88340.1 - 0.018 15.7 1.0 0.44 11.3 1.8 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) EzrA PF06160.12 CRG88340.1 - 0.024 12.8 1.9 0.035 12.3 1.9 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA V_ATPase_I PF01496.19 CRG88340.1 - 0.045 11.7 1.0 0.055 11.4 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4201 PF13870.6 CRG88340.1 - 0.049 13.4 7.8 0.62 9.8 7.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Wtap PF17098.5 CRG88340.1 - 0.054 13.4 5.7 0.049 13.6 3.9 1.8 2 0 0 2 2 2 0 WTAP/Mum2p family ADIP PF11559.8 CRG88340.1 - 0.059 13.4 5.2 3.9 7.6 3.4 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Prominin PF05478.11 CRG88340.1 - 0.076 11.0 1.8 0.11 10.5 1.8 1.2 1 0 0 1 1 1 0 Prominin KASH_CCD PF14662.6 CRG88340.1 - 0.077 12.8 8.1 0.49 10.2 3.6 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Cep57_MT_bd PF06657.13 CRG88340.1 - 0.083 13.3 4.1 5.1 7.6 0.2 3.1 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF5333 PF17267.2 CRG88340.1 - 0.094 12.9 1.2 8.2 6.7 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5333) Tropomyosin_1 PF12718.7 CRG88340.1 - 0.13 12.4 6.0 0.25 11.5 6.0 1.5 1 0 0 1 1 1 0 Tropomyosin like Retrotrans_gag PF03732.17 CRG88340.1 - 0.13 12.5 1.2 0.37 11.1 0.1 2.3 2 1 0 2 2 2 0 Retrotransposon gag protein Fib_alpha PF08702.10 CRG88340.1 - 0.14 12.3 3.9 0.25 11.5 2.8 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family TBCC_N PF16752.5 CRG88340.1 - 0.17 12.3 4.0 0.48 10.9 3.0 2.2 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain FlaC_arch PF05377.11 CRG88340.1 - 0.26 11.7 5.4 1.7 9.1 0.6 3.3 2 1 0 3 3 2 0 Flagella accessory protein C (FlaC) Ax_dynein_light PF10211.9 CRG88340.1 - 0.27 11.1 4.3 0.82 9.6 2.1 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain UPF0242 PF06785.11 CRG88340.1 - 0.32 11.1 6.6 0.12 12.5 3.6 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CLZ PF16526.5 CRG88340.1 - 0.33 11.3 5.0 0.52 10.7 0.6 2.6 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Sec2p PF06428.11 CRG88340.1 - 0.39 10.7 7.8 1.2 9.1 1.3 2.4 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Spc7 PF08317.11 CRG88340.1 - 0.41 9.5 6.3 0.72 8.7 6.3 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Cytochrom_B562 PF07361.11 CRG88340.1 - 0.6 10.8 6.5 0.49 11.1 2.0 2.7 1 1 1 2 2 2 0 Cytochrome b562 APG6_N PF17675.1 CRG88340.1 - 1.3 9.5 9.6 1.7 9.1 0.2 3.0 2 1 1 3 3 3 0 Apg6 coiled-coil region TMPIT PF07851.13 CRG88340.1 - 1.9 7.6 4.3 4.5 6.4 4.1 1.7 1 1 0 1 1 1 0 TMPIT-like protein DUF724 PF05266.14 CRG88340.1 - 2 8.2 7.1 3.3 7.5 5.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) CENP-H PF05837.12 CRG88340.1 - 2 8.8 8.4 4.2 7.8 3.4 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FAA_hydrolase PF01557.18 CRG88341.1 - 4.7e-48 163.7 0.0 8.6e-48 162.9 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Pkinase PF00069.25 CRG88341.1 - 5.1e-43 147.3 0.0 8.3e-43 146.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88341.1 - 6.7e-15 55.1 0.0 1.3e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CRG88341.1 - 0.0075 15.9 0.1 0.012 15.2 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 CRG88341.1 - 0.0088 15.4 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CRG88341.1 - 0.021 13.6 0.4 0.093 11.5 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 CRG88341.1 - 0.14 12.1 0.0 0.58 10.0 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 CRG88341.1 - 0.21 10.8 0.0 0.39 10.0 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Ysc84 PF04366.12 CRG88342.1 - 1.7 8.4 6.3 0.88 9.3 0.5 2.8 2 1 0 2 2 2 0 Las17-binding protein actin regulator PWI PF01480.17 CRG88343.1 - 5.3e-29 100.4 0.0 1e-28 99.5 0.0 1.5 1 0 0 1 1 1 1 PWI domain DUF4733 PF15878.5 CRG88344.1 - 0.1 13.1 0.0 0.12 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4733) Fungal_trans_2 PF11951.8 CRG88345.1 - 2.8e-06 26.4 0.7 1.4e-05 24.1 0.6 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88345.1 - 0.33 11.1 4.8 0.79 9.9 4.8 1.6 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 CRG88346.1 - 8.1e-33 113.5 0.0 1.1e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88346.1 - 1.4e-19 70.6 0.0 1.7e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88346.1 - 5.5e-06 26.4 0.1 8e-06 25.9 0.1 1.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG88346.1 - 0.00024 21.1 0.2 0.0005 20.0 0.2 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG88346.1 - 0.00096 18.7 0.0 0.0043 16.5 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 CRG88346.1 - 0.00099 19.4 0.1 0.0016 18.7 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CRG88346.1 - 0.001 19.1 0.0 0.0017 18.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 CRG88346.1 - 0.0053 16.4 0.1 0.011 15.4 0.0 1.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Hydrolase_6 PF13344.6 CRG88347.1 - 9.6e-30 102.7 0.0 2.2e-29 101.5 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG88347.1 - 3.1e-14 52.8 0.0 9.1e-14 51.3 0.1 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 CRG88347.1 - 5.9e-12 46.3 0.0 2.8e-09 37.6 0.0 3.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CRG88347.1 - 5.4e-05 23.4 0.0 0.042 13.9 0.0 2.5 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase RRG8 PF17068.5 CRG88348.1 - 0.0075 15.7 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial DUF1601 PF07671.11 CRG88348.1 - 0.11 12.4 0.1 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1601) F-box-like PF12937.7 CRG88349.1 - 4.7e-07 29.6 0.1 9.6e-07 28.6 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG88349.1 - 0.0089 15.9 0.5 0.042 13.7 0.1 2.3 2 0 0 2 2 2 1 F-box domain MFS_1 PF07690.16 CRG88351.1 - 7.6e-37 127.0 38.5 7.6e-37 127.0 38.5 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 CRG88354.1 - 6.2e-13 49.5 0.0 1e-12 48.8 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG88354.1 - 1.2e-10 41.7 0.0 2.4e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1365 PF07103.11 CRG88355.1 - 9.3e-53 179.3 0.1 1.4e-52 178.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1365) APH PF01636.23 CRG88356.1 - 4.5e-11 43.1 0.1 6.1e-11 42.7 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG88356.1 - 0.011 15.3 0.1 0.012 15.2 0.1 1.4 1 1 0 1 1 1 0 Choline/ethanolamine kinase p450 PF00067.22 CRG88357.1 - 2.1e-69 234.5 0.0 2.8e-69 234.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 3HCDH_N PF02737.18 CRG88357.1 - 4.8e-27 95.0 0.0 8.4e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CRG88357.1 - 4.4e-09 36.8 0.0 1e-08 35.6 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CRG88357.1 - 0.022 14.9 0.0 0.046 13.9 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Ldl_recept_b PF00058.17 CRG88357.1 - 0.051 14.1 1.6 0.91 10.1 0.0 3.2 3 0 0 3 3 3 0 Low-density lipoprotein receptor repeat class B NAD_binding_1 PF00175.21 CRG88358.1 - 6.5e-33 113.6 0.0 1.1e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CRG88358.1 - 3.9e-27 94.5 0.0 6.7e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 CRG88358.1 - 1e-22 80.1 0.3 1.7e-22 79.3 0.3 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 CRG88358.1 - 7.5e-06 26.2 0.0 0.00017 21.8 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 CRG88358.1 - 0.0017 18.6 0.0 0.0084 16.3 0.0 2.0 1 1 1 2 2 2 1 Siderophore-interacting FAD-binding domain TauE PF01925.19 CRG88358.1 - 0.014 15.0 0.4 0.024 14.3 0.4 1.3 1 0 0 1 1 1 0 Sulfite exporter TauE/SafE Glyco_transf_28 PF03033.20 CRG88360.1 - 0.00018 21.6 0.1 0.00084 19.4 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain DUF5569 PF17729.1 CRG88360.1 - 0.0048 16.8 0.1 0.0082 16.0 0.1 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5569) FR47 PF08445.10 CRG88361.1 - 1.1e-05 25.3 0.0 3.1e-05 23.9 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CRG88361.1 - 0.002 18.8 0.0 0.0037 17.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG88361.1 - 0.0069 16.8 0.0 0.015 15.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG88361.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Putative_PNPOx PF01243.20 CRG88361.1 - 0.083 13.1 0.0 0.23 11.7 0.0 1.7 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase CLP_protease PF00574.23 CRG88362.1 - 2.3e-76 255.7 0.0 2.8e-76 255.5 0.0 1.0 1 0 0 1 1 1 1 Clp protease SDH_sah PF01972.16 CRG88362.1 - 0.11 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Serine dehydrogenase proteinase Tugs PF17840.1 CRG88362.1 - 0.17 12.1 0.6 0.39 10.9 0.6 1.6 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain RRM_1 PF00076.22 CRG88363.1 - 1e-39 134.1 0.0 9.3e-20 70.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG88363.1 - 0.0035 17.4 0.0 0.87 9.7 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif FR47 PF08445.10 CRG88366.1 - 2.2e-06 27.5 0.1 6.7e-06 26.0 0.1 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CRG88366.1 - 0.00057 20.6 0.0 0.0013 19.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG88366.1 - 0.0053 17.0 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG88366.1 - 0.087 13.3 0.0 0.16 12.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF515 PF04415.12 CRG88368.1 - 0.072 11.5 0.9 0.081 11.3 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) SIR2 PF02146.17 CRG88369.1 - 1.5e-29 103.1 0.8 4.9e-23 82.0 0.1 2.3 1 1 1 2 2 2 2 Sir2 family F-box-like PF12937.7 CRG88369.1 - 0.00016 21.5 0.7 0.00034 20.4 0.7 1.6 1 0 0 1 1 1 1 F-box-like TPP_enzyme_M PF00205.22 CRG88369.1 - 0.073 12.8 0.0 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain OrfB_Zn_ribbon PF07282.11 CRG88369.1 - 6.7 6.7 6.3 17 5.4 0.4 2.4 1 1 1 2 2 2 0 Putative transposase DNA-binding domain G_glu_transpept PF01019.21 CRG88370.1 - 3.6e-131 438.4 0.0 4.4e-131 438.2 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF2396 PF09654.10 CRG88370.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2396) Lyase_1 PF00206.20 CRG88371.1 - 3.5e-86 289.4 0.0 6e-86 288.7 0.0 1.4 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 CRG88371.1 - 9.8e-23 80.7 0.0 3.5e-22 78.9 0.0 2.0 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal Apo-CIII PF05778.12 CRG88371.1 - 0.047 13.3 0.1 0.51 10.0 0.0 2.4 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) Goodbye PF17109.5 CRG88372.1 - 1e-29 103.4 2.0 1.9e-29 102.6 0.0 2.6 3 0 0 3 3 3 1 fungal STAND N-terminal Goodbye domain AAA_22 PF13401.6 CRG88372.1 - 1.2e-05 25.6 0.0 0.00013 22.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CRG88372.1 - 0.00013 22.4 0.0 0.0007 20.0 0.0 2.4 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CRG88372.1 - 0.0034 17.3 0.0 0.0095 15.9 0.0 1.8 1 0 0 1 1 1 1 NACHT domain IstB_IS21 PF01695.17 CRG88372.1 - 0.0086 15.8 0.0 0.023 14.4 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_29 PF13555.6 CRG88372.1 - 0.01 15.5 0.0 0.029 14.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TPR_10 PF13374.6 CRG88372.1 - 0.028 14.3 0.4 30 4.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88372.1 - 0.056 13.9 0.0 2.9 8.5 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Sigma54_activat PF00158.26 CRG88372.1 - 0.062 13.0 0.0 0.32 10.7 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 CRG88372.1 - 0.063 13.8 0.4 0.28 11.7 0.0 2.3 2 0 0 2 2 2 0 ABC transporter FYVE PF01363.21 CRG88372.1 - 2.2 8.5 8.0 0.31 11.2 3.7 1.8 2 0 0 2 2 1 0 FYVE zinc finger PRELI PF04707.14 CRG88373.1 - 4.3e-24 85.1 0.0 2.3e-21 76.3 0.0 2.1 2 0 0 2 2 2 2 PRELI-like family Aminotran_4 PF01063.19 CRG88374.1 - 1.6e-35 123.0 0.0 2.1e-35 122.6 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV TPR_1 PF00515.28 CRG88375.1 - 2.9e-38 128.2 22.1 1.6e-07 30.8 0.1 11.3 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88375.1 - 1.7e-36 121.4 24.0 1.2e-06 28.2 0.1 10.6 11 0 0 11 11 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 CRG88375.1 - 6.4e-24 84.3 10.8 7.1e-07 29.8 0.1 6.9 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88375.1 - 6.9e-22 75.8 20.2 3.7e-05 23.6 0.0 10.5 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88375.1 - 1.9e-18 65.5 10.6 0.04 14.3 0.0 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 CRG88375.1 - 4.3e-15 55.1 24.9 2.4e-07 30.3 0.1 8.0 6 1 2 8 8 8 5 TPR repeat TPR_12 PF13424.6 CRG88375.1 - 4.8e-15 55.6 24.6 0.0041 17.4 0.6 8.1 4 2 4 8 8 8 5 Tetratricopeptide repeat TPR_9 PF13371.6 CRG88375.1 - 1.4e-14 54.0 5.7 3.3e-05 23.9 0.1 6.0 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88375.1 - 3e-13 50.1 19.6 0.00051 20.5 0.3 8.0 6 1 3 9 9 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88375.1 - 7.4e-13 48.2 15.5 0.015 16.1 0.0 8.8 6 2 4 10 10 8 3 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88375.1 - 1.7e-12 46.4 14.4 0.031 14.3 0.1 9.2 9 1 1 10 10 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG88375.1 - 3.6e-07 30.3 13.5 0.02 15.1 0.0 5.8 3 2 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 CRG88375.1 - 2.2e-06 27.3 3.0 0.087 12.2 0.0 3.4 1 1 1 3 3 3 2 MalT-like TPR region TPR_10 PF13374.6 CRG88375.1 - 2.4e-06 27.2 12.3 0.76 9.7 0.2 8.2 9 0 0 9 9 8 1 Tetratricopeptide repeat MAS20 PF02064.15 CRG88375.1 - 0.00053 20.1 10.5 0.0016 18.6 1.3 4.0 4 1 0 4 4 4 1 MAS20 protein import receptor TPR_4 PF07721.14 CRG88375.1 - 0.00097 19.5 1.0 28 5.7 0.2 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 CRG88375.1 - 0.0035 16.7 6.3 1.8 8.1 0.1 5.8 6 0 0 6 6 6 1 SHNi-TPR BTAD PF03704.17 CRG88375.1 - 0.015 15.8 2.2 20 5.6 0.0 4.6 4 2 1 5 5 5 0 Bacterial transcriptional activator domain DUF3306 PF11748.8 CRG88375.1 - 0.025 15.4 3.9 0.073 13.9 3.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Sel1 PF08238.12 CRG88375.1 - 0.03 15.0 1.3 13 6.6 0.2 3.5 2 0 0 2 2 2 0 Sel1 repeat DUF3856 PF12968.7 CRG88375.1 - 0.037 14.1 4.7 4.8 7.2 0.0 4.8 4 2 1 5 5 5 0 Domain of Unknown Function (DUF3856) IPPT PF01715.17 CRG88375.1 - 0.064 13.1 4.1 0.17 11.7 1.6 2.8 2 1 0 2 2 2 0 IPP transferase TPR_6 PF13174.6 CRG88375.1 - 0.072 13.8 23.5 40 5.1 0.7 8.8 9 0 0 9 9 9 0 Tetratricopeptide repeat PknG_TPR PF16918.5 CRG88375.1 - 0.076 11.7 1.2 0.72 8.5 0.1 2.8 3 1 1 4 4 4 0 Protein kinase G tetratricopeptide repeat ANAPC5 PF12862.7 CRG88375.1 - 0.082 13.0 6.5 5.7 7.1 0.1 4.4 3 1 2 5 5 3 0 Anaphase-promoting complex subunit 5 Phage_lysozyme2 PF18013.1 CRG88375.1 - 0.35 10.9 2.1 0.72 9.9 0.0 2.6 3 0 0 3 3 2 0 Phage tail lysozyme NARP1 PF12569.8 CRG88375.1 - 2.1 7.2 28.4 0.62 8.9 2.6 4.8 2 1 2 4 4 4 0 NMDA receptor-regulated protein 1 SWIRM-assoc_2 PF16496.5 CRG88375.1 - 5 5.9 11.5 8.4 5.1 11.5 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Glyco_hydro_71 PF03659.14 CRG88376.1 - 1.3e-130 435.6 9.7 1.5e-130 435.4 9.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Amidase PF01425.21 CRG88377.1 - 1.7e-85 287.7 0.0 2.2e-85 287.3 0.0 1.1 1 0 0 1 1 1 1 Amidase adh_short PF00106.25 CRG88378.1 - 9.7e-19 67.6 0.0 1.3e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88378.1 - 5e-11 42.6 0.0 7e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88378.1 - 0.0022 17.9 0.1 0.004 17.1 0.1 1.3 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CRG88378.1 - 0.05 13.7 0.0 0.094 12.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Arena_RNA_pol PF06317.11 CRG88378.1 - 0.13 9.5 0.0 0.17 9.1 0.0 1.1 1 0 0 1 1 1 0 Arenavirus RNA polymerase TRI12 PF06609.13 CRG88379.1 - 1.4e-26 93.1 22.9 5.8e-16 58.0 10.4 2.0 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CRG88379.1 - 4.7e-11 42.2 39.1 4.7e-11 42.2 39.1 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily DSBA PF01323.20 CRG88379.1 - 0.0053 16.5 0.1 0.0086 15.9 0.1 1.2 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Amidase PF01425.21 CRG88380.1 - 1.6e-80 271.3 0.0 2.4e-80 270.7 0.0 1.2 1 0 0 1 1 1 1 Amidase Zn_clus PF00172.18 CRG88381.1 - 1.1e-09 38.2 17.7 3.8e-07 30.1 11.0 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG88381.1 - 1.3e-09 37.5 9.0 0.00016 20.8 0.6 3.8 2 2 1 3 3 3 3 Fungal specific transcription factor domain PSI_integrin PF17205.3 CRG88381.1 - 0.03 14.0 8.4 0.31 10.8 3.3 2.7 2 0 0 2 2 2 0 Integrin plexin domain Reprolysin_5 PF13688.6 CRG88381.1 - 0.08 13.1 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Metallo-peptidase family M12 Ank_2 PF12796.7 CRG88382.1 - 9.4e-61 202.4 5.0 1.5e-16 60.8 0.1 4.9 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG88382.1 - 9.4e-40 130.1 0.0 6.8e-05 23.0 0.0 9.1 9 0 0 9 9 9 7 Ankyrin repeat Ank_4 PF13637.6 CRG88382.1 - 1.4e-34 118.0 0.1 3.8e-09 36.9 0.0 6.4 4 3 4 8 8 8 7 Ankyrin repeats (many copies) Ank PF00023.30 CRG88382.1 - 2.8e-32 109.7 0.0 7.4e-06 26.2 0.1 7.9 8 0 0 8 8 8 6 Ankyrin repeat Ank_5 PF13857.6 CRG88382.1 - 1.1e-30 105.2 1.6 4.5e-08 33.2 0.1 6.3 4 2 2 6 6 6 6 Ankyrin repeats (many copies) PEGA PF08308.11 CRG88382.1 - 0.00011 22.0 0.1 3.1 7.7 0.0 3.7 4 0 0 4 4 4 2 PEGA domain DUF3383 PF11863.8 CRG88382.1 - 0.087 11.8 0.0 3.8 6.4 0.0 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF3383) TusA PF01206.17 CRG88382.1 - 0.11 12.3 0.0 1.3 8.9 0.0 2.5 2 0 0 2 2 2 0 Sulfurtransferase TusA RNase_H PF00075.24 CRG88384.1 - 2.4e-10 40.8 0.1 3.2e-10 40.4 0.1 1.2 1 0 0 1 1 1 1 RNase H FAD_binding_3 PF01494.19 CRG88385.1 - 6.5e-16 58.5 0.0 8.2e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG88385.1 - 0.00077 19.1 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CRG88385.1 - 0.014 14.7 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase SE PF08491.10 CRG88385.1 - 0.045 12.8 0.0 1.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase Pyr_redox PF00070.27 CRG88385.1 - 0.11 13.1 1.2 0.3 11.7 0.1 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase ACTH_domain PF00976.18 CRG88385.1 - 0.72 9.8 0.0 0.72 9.8 0.0 2.9 4 0 0 4 4 4 0 Corticotropin ACTH domain ADH_zinc_N PF00107.26 CRG88386.1 - 1.4e-10 41.3 0.0 2.5e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88386.1 - 2.3e-05 24.2 3.8 3e-05 23.9 0.2 2.7 3 1 1 4 4 4 1 Alcohol dehydrogenase GroES-like domain MFS_1 PF07690.16 CRG88387.1 - 1.3e-36 126.2 45.2 1.3e-36 126.2 45.2 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG88387.1 - 2e-10 39.8 18.0 2e-10 39.8 18.0 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) NDUF_B12 PF08122.12 CRG88387.1 - 2.5 8.2 6.9 6.3 6.9 0.1 4.2 3 1 1 4 4 4 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF3723 PF12520.8 CRG88388.1 - 1.1e-36 126.7 0.9 1.2e-28 100.1 0.2 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3723) WD40 PF00400.32 CRG88389.1 - 2.1e-17 63.2 1.0 4e-12 46.4 0.0 3.0 3 1 1 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88389.1 - 0.00012 22.3 0.0 0.00084 19.6 0.0 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG88389.1 - 0.022 13.7 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 CRG88389.1 - 0.081 12.5 0.7 0.78 9.3 0.7 2.3 1 1 0 1 1 1 0 PQQ-like domain PQQ_3 PF13570.6 CRG88389.1 - 0.11 13.0 0.2 7.2 7.2 0.0 2.5 2 0 0 2 2 2 0 PQQ-like domain p450 PF00067.22 CRG88390.1 - 3.4e-51 174.4 0.0 4.4e-51 174.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 NAD_binding_4 PF07993.12 CRG88391.1 - 1.8e-14 53.6 0.0 2.6e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 CRG88391.1 - 7.2e-14 51.2 0.0 1.1e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CRG88391.1 - 3.9e-07 30.3 0.0 8.6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 CRG88391.1 - 0.00031 20.0 0.0 0.00046 19.4 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 CRG88391.1 - 0.0045 17.4 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain KR PF08659.10 CRG88391.1 - 0.0097 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 KR domain DapB_N PF01113.20 CRG88391.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 CRG88391.1 - 0.17 11.3 0.0 0.32 10.4 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 CRG88392.1 - 4.1e-24 85.1 0.0 3.2e-18 65.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88392.1 - 5e-16 59.0 0.0 4.8e-11 42.7 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88392.1 - 8e-08 32.4 0.0 1.3e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG88392.1 - 0.0062 15.7 0.0 0.0081 15.3 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GMC_oxred_N PF00732.19 CRG88393.1 - 6.5e-50 170.2 0.0 8.4e-50 169.8 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG88393.1 - 5.6e-35 121.0 0.1 1e-34 120.2 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CRG88393.1 - 5.4e-07 29.0 0.6 0.0015 17.7 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 CRG88393.1 - 2.2e-05 23.9 1.8 0.11 11.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG88393.1 - 2.6e-05 23.6 0.2 0.0048 16.2 0.1 2.3 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 CRG88393.1 - 3.4e-05 23.6 0.3 0.00074 19.2 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG88393.1 - 0.00038 20.6 0.2 0.00097 19.3 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG88393.1 - 0.00046 19.5 0.2 0.0013 18.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG88393.1 - 0.0035 16.4 1.5 0.0047 16.0 0.0 1.9 3 0 0 3 3 3 1 Lycopene cyclase protein Trp_halogenase PF04820.14 CRG88393.1 - 0.004 16.1 0.1 0.0056 15.6 0.1 1.2 1 0 0 1 1 1 1 Tryptophan halogenase GIDA PF01134.22 CRG88393.1 - 0.017 14.3 1.0 1.4 7.9 0.1 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 CRG88393.1 - 0.17 11.9 0.1 0.4 10.7 0.1 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding p450 PF00067.22 CRG88395.1 - 3.8e-52 177.6 0.0 1.2e-49 169.3 0.0 2.9 2 1 1 3 3 3 3 Cytochrome P450 MRP-L27 PF09809.9 CRG88397.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 FHA PF00498.26 CRG88398.1 - 1.2e-12 48.0 0.1 2.5e-12 46.9 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 CRG88398.1 - 0.00071 19.8 0.0 0.002 18.4 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Abhydrolase_2 PF02230.16 CRG88399.1 - 8.6e-22 78.0 0.7 1.2e-07 31.8 0.0 4.1 4 0 0 4 4 4 4 Phospholipase/Carboxylesterase FSH1 PF03959.13 CRG88399.1 - 0.0038 16.9 0.0 0.0092 15.7 0.0 1.8 2 1 0 2 2 2 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 CRG88399.1 - 0.2 12.2 5.1 4.8 7.7 5.0 2.2 1 1 0 1 1 1 0 Alpha/beta hydrolase family Secretin_N_2 PF07655.13 CRG88399.1 - 7.9 7.1 13.2 30 5.2 0.2 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain FA_desaturase PF00487.24 CRG88400.1 - 5.9e-17 62.3 21.2 5.9e-17 62.3 21.2 1.6 1 1 1 2 2 2 1 Fatty acid desaturase Sec1 PF00995.23 CRG88401.1 - 3.2e-127 426.2 0.0 3.7e-127 426.0 0.0 1.0 1 0 0 1 1 1 1 Sec1 family HCV_core PF01542.18 CRG88401.1 - 0.13 12.6 0.0 0.28 11.6 0.0 1.5 1 0 0 1 1 1 0 Hepatitis C virus core protein zf_CCCH_4 PF18345.1 CRG88402.1 - 2.6e-05 24.1 3.9 4.2e-05 23.5 3.9 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 CRG88402.1 - 0.0024 17.6 2.6 0.0038 17.0 2.6 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger 14-3-3 PF00244.20 CRG88402.1 - 0.0032 17.0 0.5 0.0069 15.9 0.5 1.5 1 0 0 1 1 1 1 14-3-3 protein zf-CCCH_3 PF15663.5 CRG88402.1 - 0.022 15.0 0.1 0.022 15.0 0.1 1.9 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 CRG88402.1 - 0.036 14.5 3.1 0.063 13.8 3.1 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger HMG_box_2 PF09011.10 CRG88402.1 - 0.047 14.3 3.5 0.14 12.8 3.5 1.8 1 0 0 1 1 1 0 HMG-box domain zf-CCCH PF00642.24 CRG88402.1 - 0.094 12.7 0.8 0.15 12.0 0.8 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HORMA PF02301.18 CRG88404.1 - 2.9e-33 115.2 0.1 3.5e-33 115.0 0.1 1.0 1 0 0 1 1 1 1 HORMA domain Arcadin_1 PF18653.1 CRG88404.1 - 0.0088 16.1 0.0 2.1 8.5 0.0 2.2 2 0 0 2 2 2 2 Arcadin 1 DUF2660 PF10859.8 CRG88404.1 - 0.03 14.8 0.1 0.092 13.2 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) Csm1_B PF18211.1 CRG88404.1 - 0.11 12.3 0.6 0.32 10.8 0.1 2.1 2 1 0 2 2 2 0 Csm1 subunit domain B Tfb5 PF06331.12 CRG88404.1 - 0.12 12.4 0.2 2.4 8.2 0.0 2.2 2 0 0 2 2 2 0 Transcription factor TFIIH complex subunit Tfb5 DUF3235 PF11574.8 CRG88404.1 - 0.35 11.8 3.2 0.81 10.6 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) GTP_EFTU PF00009.27 CRG88405.1 - 1.7e-50 171.3 0.0 2.6e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 CRG88405.1 - 2.3e-43 146.7 2.6 4e-43 145.9 2.6 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 CRG88405.1 - 2.4e-18 65.9 0.0 5.9e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CRG88405.1 - 1.5e-05 25.2 0.1 4.1e-05 23.9 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 CRG88405.1 - 3.1e-05 23.6 0.0 0.00016 21.3 0.0 2.0 2 0 0 2 2 2 1 Ras family MMR_HSR1 PF01926.23 CRG88405.1 - 3.2e-05 24.0 0.0 7e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 CRG88405.1 - 0.0038 17.3 0.0 0.0093 16.0 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 CRG88405.1 - 0.0069 16.2 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 CRG88405.1 - 0.018 14.5 0.0 0.047 13.1 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 CRG88405.1 - 0.074 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Snurportin1 PF11538.8 CRG88405.1 - 0.079 13.2 1.1 0.2 11.9 1.1 1.6 1 0 0 1 1 1 0 Snurportin1 Opy2 PF09463.10 CRG88406.1 - 0.012 15.9 23.8 0.02 15.2 23.8 1.4 1 0 0 1 1 1 0 Opy2 protein PALP PF00291.25 CRG88407.1 - 1.4e-63 215.0 3.1 1.9e-63 214.6 3.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SOXp PF12336.8 CRG88407.1 - 0.016 16.2 0.0 0.064 14.3 0.0 2.0 2 0 0 2 2 2 0 SOX transcription factor YjeF_N PF03853.15 CRG88407.1 - 0.1 12.5 0.9 7.8 6.4 0.1 3.0 2 1 1 3 3 3 0 YjeF-related protein N-terminus Homeobox_KN PF05920.11 CRG88408.1 - 6.7e-17 61.1 2.8 1.2e-16 60.3 0.4 2.3 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 CRG88408.1 - 1.6e-09 37.5 0.3 1.6e-09 37.5 0.3 2.5 3 0 0 3 3 3 1 Homeodomain Homez PF11569.8 CRG88408.1 - 0.0066 15.9 0.1 0.028 13.9 0.1 2.1 1 0 0 1 1 1 1 Homeodomain leucine-zipper encoding, Homez zf-C2H2_2 PF12756.7 CRG88408.1 - 0.055 13.8 8.5 0.62 10.4 2.1 2.9 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) HTH_36 PF13730.6 CRG88408.1 - 0.062 13.3 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain CcmD PF04995.14 CRG88408.1 - 3.7 7.7 6.3 0.4 10.8 0.9 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Zn_clus PF00172.18 CRG88408.1 - 7.1 6.9 9.8 0.78 9.9 3.8 2.5 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Chitin_synth_1 PF01644.17 CRG88409.1 - 5.6e-69 231.3 0.0 8.2e-69 230.7 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase UQ_con PF00179.26 CRG88409.1 - 1.1e-36 125.6 0.0 1.8e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Chitin_synth_1N PF08407.11 CRG88409.1 - 3e-28 97.6 0.0 6.2e-28 96.6 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CRG88409.1 - 1.7e-24 86.4 0.0 3.9e-20 72.0 0.0 2.1 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CRG88409.1 - 2e-09 37.7 0.0 2e-09 37.7 0.0 2.2 3 0 0 3 3 3 1 Glycosyl transferase family group 2 TAF8_C PF10406.9 CRG88410.1 - 3.6e-21 75.4 0.3 1.2e-20 73.7 0.3 2.0 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 CRG88410.1 - 9.8e-12 44.7 0.0 1e-10 41.5 0.0 2.1 2 0 0 2 2 2 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 CRG88410.1 - 1.6 9.0 3.7 19 5.6 0.0 2.9 4 0 0 4 4 4 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Mitochondr_Som1 PF11093.8 CRG88411.1 - 9.2e-16 57.6 0.0 1e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Rad51 PF08423.11 CRG88412.1 - 8.9e-05 21.9 0.0 0.00048 19.5 0.0 1.9 2 0 0 2 2 2 1 Rad51 TniB PF05621.11 CRG88412.1 - 0.046 13.1 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PALP PF00291.25 CRG88413.1 - 7.6e-66 222.5 0.5 9.4e-66 222.2 0.5 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CRG88413.1 - 0.0062 15.9 0.0 0.0097 15.2 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF4597 PF15366.6 CRG88413.1 - 0.072 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4597) IlvN PF07991.12 CRG88414.1 - 3.2e-46 156.9 0.0 4.9e-46 156.3 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 CRG88414.1 - 2.6e-41 141.3 0.0 3.7e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 CRG88414.1 - 0.083 13.1 0.0 0.23 11.6 0.0 1.7 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Isochorismatase PF00857.20 CRG88415.1 - 3.5e-24 85.9 0.0 1.4e-23 84.0 0.0 1.9 1 1 0 1 1 1 1 Isochorismatase family 2OG-FeII_Oxy_2 PF13532.6 CRG88415.1 - 1.4e-23 84.1 0.0 2.5e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GST_C PF00043.25 CRG88415.1 - 0.00042 20.5 0.0 0.00093 19.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG88415.1 - 0.0039 17.2 0.0 0.0082 16.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG88415.1 - 0.0084 16.3 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain ECH_1 PF00378.20 CRG88416.1 - 5e-37 127.6 0.0 1.3e-36 126.3 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG88416.1 - 8.3e-25 88.0 0.0 6.2e-24 85.1 0.0 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase DUF2188 PF09954.9 CRG88416.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2188) Tfb5 PF06331.12 CRG88417.1 - 1.5e-20 72.9 0.9 1.5e-20 72.9 0.9 1.5 2 0 0 2 2 2 1 Transcription factor TFIIH complex subunit Tfb5 HSP20 PF00011.21 CRG88418.1 - 1.7e-17 63.4 0.5 3.4e-12 46.4 0.0 2.2 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CRG88418.1 - 2.7e-05 23.6 0.0 0.0002 20.9 0.0 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA MFS_1 PF07690.16 CRG88419.1 - 6e-35 120.8 53.8 6e-35 120.8 53.8 2.2 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88419.1 - 5.2e-08 32.2 13.0 5.2e-08 32.2 13.0 3.9 4 0 0 4 4 4 2 Sugar (and other) transporter OATP PF03137.20 CRG88419.1 - 0.0027 16.1 1.2 0.0027 16.1 1.2 2.6 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family PUCC PF03209.15 CRG88419.1 - 0.037 13.1 36.3 0.019 14.0 9.6 3.2 2 1 1 3 3 3 0 PUCC protein ADH_zinc_N_2 PF13602.6 CRG88420.1 - 2e-14 54.8 0.0 6.5e-14 53.1 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG88420.1 - 4.9e-08 33.0 0.1 8.5e-08 32.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88420.1 - 0.002 18.0 0.0 0.0044 16.9 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 CRG88420.1 - 0.039 13.4 0.1 0.056 12.9 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CRG88420.1 - 0.059 12.5 0.0 0.084 12.0 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain GDC-P PF02347.16 CRG88421.1 - 0.016 14.1 0.0 0.018 13.9 0.0 1.0 1 0 0 1 1 1 0 Glycine cleavage system P-protein DUF3502 PF12010.8 CRG88421.1 - 0.077 13.6 0.0 0.1 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) Form_Nir_trans PF01226.17 CRG88422.1 - 1.2e-70 237.5 15.9 1.5e-70 237.3 15.9 1.0 1 0 0 1 1 1 1 Formate/nitrite transporter DUF2107 PF09880.9 CRG88422.1 - 0.011 15.8 0.4 3.5 7.8 0.0 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2107) UPF0016 PF01169.19 CRG88422.1 - 0.64 10.4 0.0 0.64 10.4 0.0 3.0 2 1 0 2 2 2 0 Uncharacterized protein family UPF0016 Pkinase PF00069.25 CRG88423.1 - 1.5e-44 152.4 0.0 2e-44 151.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88423.1 - 5.3e-24 84.9 0.0 7.8e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DLH PF01738.18 CRG88423.1 - 9.1e-16 58.1 0.0 2.2e-15 56.8 0.0 1.6 2 0 0 2 2 2 1 Dienelactone hydrolase family Kinase-like PF14531.6 CRG88423.1 - 0.00039 19.8 0.0 0.0011 18.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 CRG88423.1 - 0.029 14.0 0.0 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CRG88423.1 - 0.042 13.8 0.3 0.1 12.5 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Abhydrolase_1 PF00561.20 CRG88423.1 - 0.066 12.8 0.0 0.91 9.1 0.1 2.4 1 1 2 3 3 3 0 alpha/beta hydrolase fold Pkinase_fungal PF17667.1 CRG88423.1 - 0.17 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase CMD PF02627.20 CRG88425.1 - 9.7e-07 28.8 0.0 7.5e-06 25.9 0.0 2.1 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Frag1 PF10277.9 CRG88426.1 - 5.3e-23 81.7 18.1 7.1e-23 81.3 18.1 1.2 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Lactonase PF10282.9 CRG88426.1 - 6.2e-21 75.0 0.0 1e-20 74.3 0.0 1.3 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF443 PF04276.12 CRG88426.1 - 0.0098 15.7 3.2 0.02 14.7 3.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF443) CE2_N PF17996.1 CRG88427.1 - 3.6e-19 68.8 0.0 7.9e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate esterase 2 N-terminal Lipase_GDSL_2 PF13472.6 CRG88427.1 - 9.9e-17 61.9 1.9 1.5e-16 61.3 1.9 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG88427.1 - 1.3e-07 31.8 0.0 1.7e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF4397 PF14344.6 CRG88427.1 - 0.028 15.2 0.1 0.085 13.6 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4397) Catalase PF00199.19 CRG88430.1 - 5e-163 542.7 0.0 6.5e-163 542.3 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase_C PF18011.1 CRG88430.1 - 6e-50 168.8 3.3 9.7e-50 168.1 3.3 1.4 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 CRG88430.1 - 1.6e-17 63.5 0.0 3.1e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Sugar_tr PF00083.24 CRG88431.1 - 1.1e-96 324.5 23.0 1.3e-96 324.3 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88431.1 - 1.3e-28 99.9 27.8 1.3e-28 99.9 27.8 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Hemerythrin PF01814.23 CRG88432.1 - 0.097 13.3 0.2 0.15 12.7 0.2 1.2 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain Med9 PF07544.13 CRG88432.1 - 0.13 12.3 0.2 0.31 11.2 0.2 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Virul_fac_BrkB PF03631.15 CRG88433.1 - 0.039 13.6 3.8 1.3 8.6 2.2 2.4 2 0 0 2 2 2 0 Virulence factor BrkB Ank_2 PF12796.7 CRG88434.1 - 3.1e-32 111.0 0.0 3.8e-09 37.0 0.0 6.8 3 3 4 8 8 8 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88434.1 - 2.5e-28 98.1 4.6 3.5e-09 37.0 0.0 8.1 7 3 2 9 9 9 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG88434.1 - 7.2e-21 74.0 0.4 7.3e-06 26.2 0.1 6.9 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG88434.1 - 9.4e-21 71.7 3.1 0.0018 18.6 0.0 10.5 11 0 0 11 11 11 6 Ankyrin repeat Ank PF00023.30 CRG88434.1 - 1.4e-16 60.1 0.0 0.0002 21.6 0.1 7.6 7 1 0 7 7 7 2 Ankyrin repeat DUF2025 PF09634.10 CRG88434.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2025) Wzz PF02706.15 CRG88435.1 - 0.18 12.1 2.0 1.3 9.3 0.3 2.6 2 0 0 2 2 2 0 Chain length determinant protein FAD_binding_4 PF01565.23 CRG88436.1 - 2e-21 76.2 0.2 5.1e-21 74.9 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CRG88436.1 - 0.0058 16.7 0.0 0.015 15.3 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like Methyltransf_23 PF13489.6 CRG88437.1 - 1.9e-15 57.1 0.0 2.7e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG88437.1 - 3e-10 40.7 0.0 8.1e-10 39.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG88437.1 - 2.6e-07 31.3 0.0 1.2e-06 29.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG88437.1 - 6.3e-07 30.0 0.0 1.3e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88437.1 - 4.4e-06 26.5 0.0 0.079 12.8 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_16 PF10294.9 CRG88437.1 - 0.00014 21.6 0.0 0.00022 21.0 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 CRG88437.1 - 0.0024 17.3 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CRG88437.1 - 0.0027 17.1 0.0 2.8 7.2 0.0 2.7 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CRG88437.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MTS PF05175.14 CRG88437.1 - 0.036 13.6 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain DUF938 PF06080.12 CRG88437.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) p450 PF00067.22 CRG88438.1 - 1.4e-50 172.4 0.0 1.8e-50 172.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2423 PF10338.9 CRG88438.1 - 0.27 11.5 0.0 0.27 11.5 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2423) MFS_1 PF07690.16 CRG88441.1 - 1.5e-34 119.5 27.1 2e-34 119.1 27.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG88441.1 - 0.00023 20.9 1.2 0.00073 19.3 1.2 1.8 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 Proton_antipo_C PF01010.19 CRG88441.1 - 0.029 14.0 0.6 0.071 12.7 0.1 1.8 2 0 0 2 2 2 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus CoA_trans PF01144.23 CRG88442.1 - 3.3e-101 337.2 3.3 6.7e-62 208.7 0.2 2.1 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 CRG88442.1 - 0.00024 21.1 0.1 0.00044 20.2 0.1 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain Mal_decarbox_Al PF16957.5 CRG88442.1 - 0.0043 15.5 0.2 0.0098 14.3 0.0 1.6 1 1 1 2 2 2 1 Malonate decarboxylase, alpha subunit, transporter Zn_clus PF00172.18 CRG88443.1 - 2.7e-05 24.2 7.6 5.9e-05 23.1 7.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TauD PF02668.16 CRG88444.1 - 9.9e-49 166.5 0.1 1.2e-48 166.3 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Ank_2 PF12796.7 CRG88445.1 - 3.9e-27 94.6 9.5 2.3e-10 40.9 0.6 4.0 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88445.1 - 8.4e-17 61.3 6.4 3e-09 37.2 0.4 5.7 2 2 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG88445.1 - 8.9e-17 60.9 5.1 5.9e-08 32.8 0.2 5.4 4 2 2 6 6 6 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG88445.1 - 1.1e-16 59.2 4.0 0.0005 20.3 0.1 7.5 7 1 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 CRG88445.1 - 6e-16 58.1 5.8 0.00041 20.7 0.3 5.2 5 0 0 5 5 5 3 Ankyrin repeat zf-C2H2_4 PF13894.6 CRG88446.1 - 1.8e-05 25.2 6.0 2 9.5 0.2 4.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG88446.1 - 8.3e-05 22.8 6.7 0.67 10.5 0.1 4.5 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 CRG88446.1 - 0.00019 21.6 9.5 0.12 12.6 0.5 4.1 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CRG88446.1 - 0.0018 18.5 10.2 0.21 11.9 0.1 3.3 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 CRG88446.1 - 0.044 14.2 10.4 0.27 11.7 0.0 4.6 5 0 0 5 5 5 0 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 CRG88446.1 - 0.31 10.9 4.6 1.2 9.0 0.7 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Zn-ribbon_8 PF09723.10 CRG88446.1 - 0.71 10.0 3.6 13 6.0 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 CRG88446.1 - 1.3 9.1 5.8 3.7 7.7 0.6 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger DAO PF01266.24 CRG88447.1 - 1.1e-34 120.6 0.0 1.6e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG88447.1 - 7.6e-06 25.4 0.0 0.0098 15.1 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG88447.1 - 1.2e-05 25.5 0.0 6.5e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ThiF PF00899.21 CRG88447.1 - 0.00071 19.0 0.0 0.0027 17.1 0.1 1.8 2 0 0 2 2 2 1 ThiF family FAD_binding_2 PF00890.24 CRG88447.1 - 0.0039 16.3 1.0 0.092 11.8 0.8 2.4 2 1 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CRG88447.1 - 0.0041 17.6 0.0 0.0098 16.4 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG88447.1 - 0.0093 15.1 0.0 1.8 7.5 0.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CRG88447.1 - 0.042 13.1 0.1 0.084 12.1 0.1 1.5 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 CRG88447.1 - 0.069 12.4 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG88447.1 - 0.11 12.5 0.3 2 8.4 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG88447.1 - 0.14 11.2 0.2 0.55 9.2 0.1 2.0 2 1 0 2 2 2 0 Lycopene cyclase protein TrkA_N PF02254.18 CRG88447.1 - 0.19 12.0 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain CMAS PF02353.20 CRG88448.1 - 1e-76 257.9 0.0 2e-76 256.9 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 CRG88448.1 - 1.2e-14 54.8 0.0 2.8e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG88448.1 - 1.1e-13 51.6 0.0 2.4e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG88448.1 - 8.4e-09 35.5 0.0 1.5e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88448.1 - 9.9e-09 35.2 0.0 2.2e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG88448.1 - 5.7e-07 30.2 0.0 1.9e-06 28.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.13 CRG88448.1 - 8e-06 25.5 0.0 1.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.7 CRG88448.1 - 8e-05 22.6 0.0 0.00021 21.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 CRG88448.1 - 0.00028 20.7 0.0 0.00045 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CRG88448.1 - 0.00056 19.5 0.0 0.00097 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CRG88448.1 - 0.00075 18.9 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CRG88449.1 - 1.6e-12 47.9 0.0 3e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG88449.1 - 2.2e-11 44.2 0.0 3.6e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG88449.1 - 2.7e-11 43.3 0.0 3.8e-11 42.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG88449.1 - 6.3e-10 39.7 0.0 1.1e-09 39.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88449.1 - 6.6e-10 39.0 0.0 9.7e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG88449.1 - 3e-06 27.2 0.0 3.9e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG88449.1 - 0.096 12.2 0.1 0.18 11.4 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain TehB PF03848.14 CRG88449.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB SUR7 PF06687.12 CRG88450.1 - 7.2e-49 166.3 4.9 8.5e-49 166.1 4.9 1.0 1 0 0 1 1 1 1 SUR7/PalI family Lectin_N PF03954.14 CRG88450.1 - 0.03 14.1 0.0 0.056 13.2 0.0 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain PMP22_Claudin PF00822.20 CRG88450.1 - 0.32 10.8 13.6 0.32 10.9 5.7 2.5 3 0 0 3 3 3 0 PMP-22/EMP/MP20/Claudin family MARVEL PF01284.23 CRG88450.1 - 2.2 8.3 16.5 11 6.1 16.4 2.3 1 1 0 1 1 1 0 Membrane-associating domain Fungal_trans_2 PF11951.8 CRG88451.1 - 0.0028 16.5 0.9 0.0049 15.7 0.1 1.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.26 CRG88452.1 - 3.1e-23 82.2 0.4 5.6e-23 81.4 0.4 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG88452.1 - 5.1e-15 56.7 0.5 9.9e-15 55.8 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88452.1 - 2.8e-09 36.8 0.0 5.2e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Asparaginase_C PF17763.1 CRG88452.1 - 0.022 15.0 0.3 2.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain ADH_N_2 PF16884.5 CRG88452.1 - 0.026 14.4 0.1 0.093 12.6 0.0 2.0 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase Peptidase_S41 PF03572.18 CRG88453.1 - 2e-08 34.0 0.0 4.2e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase family S41 MFS_1 PF07690.16 CRG88454.1 - 4.7e-52 177.1 90.0 2e-42 145.4 61.7 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88454.1 - 6.2e-06 25.3 28.3 0.0007 18.6 4.4 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter YlaH PF14036.6 CRG88454.1 - 0.72 10.2 5.4 2.2 8.7 0.5 3.2 2 0 0 2 2 2 0 YlaH-like protein UcrQ PF02939.16 CRG88455.1 - 3e-33 113.6 0.3 4.8e-33 112.9 0.3 1.3 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 CRG88455.1 - 0.13 12.6 0.0 0.29 11.6 0.0 1.6 1 0 0 1 1 1 0 Cytochrome b-c1 complex subunit 8 2OG-FeII_Oxy PF03171.20 CRG88456.1 - 1.1e-17 64.4 0.0 2.6e-17 63.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pur_ac_phosph_N PF16656.5 CRG88456.1 - 1.3e-15 57.7 5.2 3.1e-15 56.5 5.2 1.6 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 CRG88456.1 - 1.4e-14 55.1 0.0 3e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 CRG88456.1 - 2e-14 54.2 0.0 5.4e-14 52.8 0.0 1.8 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C PhoD_N PF16655.5 CRG88456.1 - 0.00021 21.7 0.2 0.00056 20.4 0.2 1.7 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain ADD_DNMT3 PF17980.1 CRG88456.1 - 0.059 13.4 1.4 3.2 7.8 0.1 2.7 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 fn3 PF00041.21 CRG88456.1 - 0.2 12.0 2.1 0.45 10.9 2.1 1.6 1 0 0 1 1 1 0 Fibronectin type III domain Sugar_tr PF00083.24 CRG88457.1 - 3e-89 300.0 15.8 3e-89 300.0 15.8 1.8 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG88457.1 - 1.1e-22 80.5 39.0 6e-18 64.9 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 CRG88458.1 - 4.3e-31 107.9 0.0 6.1e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88458.1 - 4.9e-27 95.0 0.0 6.4e-27 94.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88458.1 - 6.8e-10 39.1 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG88458.1 - 0.00054 19.5 0.0 0.0012 18.4 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG88458.1 - 0.0093 15.9 0.4 0.036 13.9 0.4 1.9 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG88458.1 - 0.018 14.5 0.1 0.039 13.3 0.1 1.7 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase p450 PF00067.22 CRG88459.1 - 1.7e-60 205.1 0.0 2.3e-60 204.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pox_TAP PF03355.14 CRG88459.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Viral Trans-Activator Protein DAGAT PF03982.13 CRG88460.1 - 4.5e-67 226.1 0.0 7.4e-67 225.3 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase UDPGT PF00201.18 CRG88460.1 - 2e-07 30.2 0.0 3.1e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CRG88460.1 - 0.00013 22.0 0.1 0.00023 21.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain HLH PF00010.26 CRG88461.1 - 6.2e-06 26.1 1.3 1.3e-05 25.1 0.1 2.2 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain TUSC2 PF15000.6 CRG88461.1 - 0.011 16.0 0.6 2.8 8.2 0.0 2.6 2 0 0 2 2 2 0 Tumour suppressor candidate 2 DUF2576 PF10845.8 CRG88461.1 - 0.057 13.0 0.3 0.45 10.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2576) LRR19-TM PF15176.6 CRG88462.1 - 0.054 13.5 1.3 0.12 12.4 0.3 2.1 1 1 1 2 2 2 0 Leucine-rich repeat family 19 TM domain XFP_N PF09364.10 CRG88463.1 - 9.6e-178 590.5 0.0 1.2e-177 590.2 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 CRG88463.1 - 1.8e-81 272.4 0.0 2.6e-81 271.9 0.0 1.2 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 CRG88463.1 - 6.8e-81 270.2 0.0 1.5e-80 269.1 0.0 1.6 2 0 0 2 2 2 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase AAA_15 PF13175.6 CRG88464.1 - 0.0014 18.4 1.1 0.0017 18.2 1.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain XH PF03469.14 CRG88464.1 - 0.0086 16.0 1.6 0.019 14.8 1.6 1.6 1 0 0 1 1 1 1 XH domain Exonuc_VII_L PF02601.15 CRG88464.1 - 0.015 14.9 6.6 0.026 14.1 6.6 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2229 PF09989.9 CRG88464.1 - 0.021 14.5 1.7 0.034 13.8 1.7 1.4 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) IFT57 PF10498.9 CRG88464.1 - 0.025 13.5 11.2 0.026 13.5 10.0 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Golgin_A5 PF09787.9 CRG88464.1 - 0.092 12.2 18.0 0.2 11.1 18.0 1.5 1 0 0 1 1 1 0 Golgin subfamily A member 5 Fibin PF15819.5 CRG88464.1 - 0.27 11.0 4.7 0.44 10.3 4.7 1.3 1 0 0 1 1 1 0 Fin bud initiation factor homologue ZapB PF06005.12 CRG88464.1 - 0.29 11.6 21.4 2.7 8.5 11.6 3.0 1 1 1 2 2 2 0 Cell division protein ZapB GCN5L1 PF06320.13 CRG88464.1 - 0.38 10.9 13.1 0.65 10.2 9.5 2.4 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF4472 PF14739.6 CRG88464.1 - 0.38 11.5 15.6 0.77 10.5 2.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Syntaxin-6_N PF09177.11 CRG88464.1 - 0.8 10.3 11.2 0.55 10.8 2.9 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal PRKG1_interact PF15898.5 CRG88464.1 - 0.89 10.5 18.4 9.4 7.2 15.1 2.9 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF2205 PF10224.9 CRG88464.1 - 1 9.4 16.8 9 6.4 0.1 3.5 1 1 2 3 3 3 0 Short coiled-coil protein Mod_r PF07200.13 CRG88464.1 - 1.1 9.4 16.1 1.3 9.1 13.6 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FapA PF03961.13 CRG88464.1 - 1.4 7.5 9.2 2 7.0 9.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A HAUS-augmin3 PF14932.6 CRG88464.1 - 1.4 8.5 14.5 1.4 8.5 10.2 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF4404 PF14357.6 CRG88464.1 - 1.7 9.3 10.2 3 8.5 8.9 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) COG5 PF10392.9 CRG88464.1 - 1.9 8.7 10.2 6.4 7.0 1.7 2.3 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Spc7 PF08317.11 CRG88464.1 - 2.3 7.0 19.5 5.6 5.7 19.5 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein IMD PF08397.11 CRG88464.1 - 2.8 7.2 12.5 7.4 5.9 12.5 1.7 1 1 0 1 1 1 0 IRSp53/MIM homology domain TMPIT PF07851.13 CRG88464.1 - 3.7 6.7 8.4 6.5 5.9 8.4 1.4 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 CRG88464.1 - 3.8 6.8 8.6 6.5 6.0 8.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.9 CRG88464.1 - 3.8 7.7 20.3 0.36 11.1 15.4 1.8 2 0 0 2 2 1 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.10 CRG88464.1 - 5.4 7.2 13.8 14 5.9 13.8 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family YabA PF06156.13 CRG88464.1 - 6.3 7.5 20.3 5.4 7.7 10.4 3.3 2 1 1 3 3 3 0 Initiation control protein YabA DUF1664 PF07889.12 CRG88464.1 - 9.2 6.3 9.9 28 4.7 9.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HALZ PF02183.18 CRG88464.1 - 9.2 6.6 9.2 1.8 8.9 0.2 3.1 3 0 0 3 3 3 0 Homeobox associated leucine zipper Fungal_trans PF04082.18 CRG88465.1 - 2.6e-07 29.9 0.0 4.3e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 CRG88466.1 - 2.5e-20 73.1 0.3 2.2e-10 40.3 0.1 2.9 2 1 0 2 2 2 2 FAD binding domain Fungal_trans PF04082.18 CRG88466.1 - 2.3e-13 49.8 1.8 4.3e-13 48.9 1.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain NAD_binding_8 PF13450.6 CRG88466.1 - 0.0001 22.4 0.0 0.0005 20.2 0.0 2.2 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG88466.1 - 0.00027 20.3 0.0 0.00049 19.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CRG88466.1 - 0.00028 19.7 0.0 0.0005 18.9 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 CRG88466.1 - 0.00037 19.7 0.0 0.0045 16.1 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 CRG88466.1 - 0.0011 18.6 0.2 0.067 12.8 0.1 2.5 2 1 0 3 3 3 1 FAD dependent oxidoreductase SE PF08491.10 CRG88466.1 - 0.0013 17.8 0.0 0.021 13.9 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_2 PF07992.14 CRG88466.1 - 0.006 15.9 0.0 0.0099 15.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG88466.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding Vps35 PF03635.17 CRG88466.1 - 0.029 12.9 0.3 0.052 12.1 0.3 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 35 Semialdhyde_dh PF01118.24 CRG88466.1 - 0.04 14.3 0.0 0.15 12.5 0.0 2.0 2 0 0 2 2 1 0 Semialdehyde dehydrogenase, NAD binding domain Pyr_redox PF00070.27 CRG88466.1 - 0.17 12.5 0.0 0.6 10.7 0.0 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_114 PF03537.13 CRG88467.1 - 0.066 12.5 0.3 0.11 11.7 0.3 1.4 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 Phage_holin_3_6 PF07332.11 CRG88467.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III PAN_4 PF14295.6 CRG88467.1 - 1.7 8.7 19.4 0.4 10.6 0.2 3.5 3 0 0 3 3 3 0 PAN domain MFS_1 PF07690.16 CRG88468.1 - 7.9e-37 127.0 34.4 7.9e-37 127.0 34.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SGL PF08450.12 CRG88469.1 - 2.8e-06 27.1 0.9 3.9e-05 23.3 0.9 2.7 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Sortase PF04203.13 CRG88469.1 - 0.0092 15.8 0.1 0.019 14.7 0.1 1.5 1 1 0 1 1 1 1 Sortase domain DAO PF01266.24 CRG88470.1 - 8e-50 170.4 0.1 1e-49 170.0 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 CRG88470.1 - 2.9e-41 140.3 0.0 7.9e-41 138.9 0.0 1.8 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 CRG88470.1 - 4e-08 32.8 0.4 0.00019 20.6 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 CRG88470.1 - 4.8e-05 22.9 0.2 0.00034 20.1 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG88470.1 - 0.00015 21.2 0.6 0.00044 19.6 0.6 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG88470.1 - 0.0021 17.2 0.1 0.11 11.6 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CRG88470.1 - 0.0023 18.1 0.5 0.052 13.8 0.7 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 CRG88470.1 - 0.014 15.3 0.1 0.22 11.4 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 CRG88470.1 - 0.023 14.0 0.0 0.17 11.1 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG88470.1 - 0.03 13.0 0.0 0.05 12.3 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 CRG88470.1 - 0.05 14.2 0.0 0.12 13.0 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 CRG88471.1 - 3.5e-25 88.5 0.1 6.9e-25 87.6 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG88471.1 - 7.8e-25 87.5 38.5 3.6e-24 85.4 30.7 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88471.1 - 3.8e-17 62.3 24.4 8.8e-17 61.1 24.4 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter Zn_clus PF00172.18 CRG88471.1 - 3e-05 24.1 11.1 3e-05 24.1 11.1 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fimbrillin_C PF15495.6 CRG88471.1 - 0.14 12.6 0.0 0.49 10.8 0.0 1.9 1 0 0 1 1 1 0 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal 7TM_GPCR_Srbc PF10316.9 CRG88471.1 - 0.45 10.0 3.1 1 8.8 3.1 1.6 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srbc PSI PF01437.25 CRG88471.1 - 4 8.0 8.0 0.46 11.1 3.1 2.0 2 0 0 2 2 2 0 Plexin repeat Abhydrolase_4 PF08386.10 CRG88472.1 - 6.2e-17 61.6 0.0 3.8e-16 59.1 0.0 2.1 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 CRG88472.1 - 3.1e-14 53.2 0.0 3.7e-10 39.9 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG88472.1 - 0.0077 15.5 0.0 0.77 9.0 0.0 2.9 3 0 0 3 3 3 1 Serine aminopeptidase, S33 p450 PF00067.22 CRG88473.1 - 4.8e-51 174.0 0.0 6.3e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ROQ_II PF18386.1 CRG88473.1 - 0.19 11.6 0.2 26 4.7 0.0 2.4 2 0 0 2 2 2 0 Roquin II domain Methyltransf_23 PF13489.6 CRG88474.1 - 6.3e-14 52.1 0.0 9.4e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG88474.1 - 0.0025 18.5 0.0 0.0059 17.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88474.1 - 0.0042 16.9 0.0 0.0054 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG88474.1 - 0.033 14.8 0.0 0.062 14.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CRG88474.1 - 0.044 14.5 0.0 0.097 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain NAD_binding_8 PF13450.6 CRG88475.1 - 3.3e-09 36.8 0.0 7.8e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CRG88475.1 - 4.6e-07 29.5 0.0 6.9e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Thi4 PF01946.17 CRG88475.1 - 0.001 18.3 0.1 0.0035 16.6 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 CRG88475.1 - 0.0016 17.8 0.1 0.0071 15.6 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG88475.1 - 0.0018 17.6 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG88475.1 - 0.0025 17.8 0.1 0.059 13.4 0.0 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CRG88475.1 - 0.0065 15.8 0.1 0.01 15.1 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG88475.1 - 0.019 14.6 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CRG88475.1 - 0.039 13.3 0.0 0.053 12.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG88475.1 - 0.066 11.9 0.0 0.096 11.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 CRG88475.1 - 0.16 11.0 0.1 0.25 10.4 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein TrkA_N PF02254.18 CRG88475.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain PKS_DE PF18369.1 CRG88475.1 - 0.18 12.4 0.0 2 9.0 0.0 2.3 2 0 0 2 2 2 0 Polyketide synthase dimerisation element domain Sugar_tr PF00083.24 CRG88476.1 - 2.5e-85 287.0 23.5 2.9e-85 286.8 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88476.1 - 6.1e-33 114.2 27.1 6.1e-33 114.2 27.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG88476.1 - 6.8e-05 21.9 0.0 0.00049 19.1 0.0 2.4 1 1 0 1 1 1 1 MFS_1 like family MFS_2 PF13347.6 CRG88476.1 - 0.00013 20.7 5.9 0.00013 20.7 5.9 2.4 2 0 0 2 2 2 1 MFS/sugar transport protein UNC-93 PF05978.16 CRG88476.1 - 0.00034 20.4 5.4 0.0053 16.5 0.4 2.7 2 0 0 2 2 2 2 Ion channel regulatory protein UNC-93 TRI12 PF06609.13 CRG88476.1 - 0.0057 15.1 6.1 0.0052 15.3 4.5 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 CRG88476.1 - 0.022 13.1 12.6 0.051 12.0 3.4 3.0 2 1 1 3 3 3 0 Transmembrane secretion effector Glyoxalase_6 PF18029.1 CRG88477.1 - 1.5e-06 28.9 0.1 2.4e-06 28.3 0.1 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 CRG88477.1 - 0.1 12.8 0.0 0.74 10.0 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Transp_cyt_pur PF02133.15 CRG88478.1 - 2e-84 284.0 39.8 1e-53 182.7 20.0 2.0 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin Pkinase PF00069.25 CRG88479.1 - 0.0052 16.2 0.2 0.013 14.9 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain DUF3723 PF12520.8 CRG88480.1 - 4.6e-29 101.5 0.1 1.8e-16 59.9 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3723) PDR_CDR PF06422.12 CRG88481.1 - 0.57 10.1 3.4 0.5 10.3 1.0 2.1 2 1 1 3 3 3 0 CDR ABC transporter Fungal_trans PF04082.18 CRG88482.1 - 0.00024 20.2 0.0 0.00037 19.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Histidinol_dh PF00815.20 CRG88483.1 - 6.1e-137 457.0 0.0 7.5e-137 456.7 0.0 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase Glyco_hydro_16 PF00722.21 CRG88484.1 - 9e-08 31.8 0.0 5e-07 29.4 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_75 PF07335.11 CRG88486.1 - 3.2e-40 138.1 0.3 5.1e-40 137.4 0.3 1.3 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 Glyco_hydro_76 PF03663.14 CRG88487.1 - 6e-44 151.1 25.6 8.2e-44 150.6 25.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CRG88487.1 - 2e-06 27.1 1.1 0.015 14.4 0.0 2.8 2 1 0 2 2 2 2 Glycosyl Hydrolase Family 88 Glyco_hydro_3_C PF01915.22 CRG88488.1 - 1.9e-46 158.6 0.0 3.5e-46 157.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG88488.1 - 1.7e-35 122.9 0.1 3e-35 122.1 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG88488.1 - 1.4e-24 86.0 0.1 4.2e-24 84.5 0.1 1.8 2 0 0 2 2 2 1 Fibronectin type III-like domain CorA PF01544.18 CRG88489.1 - 1.5e-10 40.8 0.1 1.8e-10 40.6 0.1 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein UPF0242 PF06785.11 CRG88489.1 - 0.043 13.9 0.6 0.065 13.3 0.3 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Colicin_V PF02674.16 CRG88489.1 - 0.05 13.6 2.5 0.12 12.3 0.6 2.0 2 0 0 2 2 2 0 Colicin V production protein TPR_10 PF13374.6 CRG88490.1 - 1.2e-149 482.8 5.4 1.6e-13 50.0 0.0 11.9 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_12 PF13424.6 CRG88490.1 - 6.9e-125 407.6 16.4 6.1e-17 61.7 0.0 11.1 2 1 9 11 11 11 10 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88490.1 - 6.5e-41 135.4 11.7 0.0037 17.2 0.0 11.3 12 0 0 12 12 11 9 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88490.1 - 3.2e-28 98.0 1.4 0.043 14.3 0.0 11.3 5 3 6 12 12 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88490.1 - 4e-26 89.5 11.7 0.13 12.7 0.0 11.2 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88490.1 - 7.6e-26 88.1 13.1 0.32 11.2 0.0 11.7 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 CRG88490.1 - 4.2e-24 83.3 20.5 0.17 11.8 0.0 11.3 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_16 PF13432.6 CRG88490.1 - 1.1e-22 80.4 0.0 0.85 10.3 0.0 10.1 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_4 PF07721.14 CRG88490.1 - 1.1e-22 78.2 0.0 0.21 12.3 0.0 10.1 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG88490.1 - 4.5e-12 46.0 2.0 0.00085 18.8 0.0 4.2 1 1 3 4 4 4 4 MalT-like TPR region PPR PF01535.20 CRG88490.1 - 9.2e-12 44.4 3.4 20 5.7 0.0 10.4 11 0 0 11 11 11 0 PPR repeat NB-ARC PF00931.22 CRG88490.1 - 1.3e-11 44.2 0.1 2.3e-11 43.4 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain PNP_UDP_1 PF01048.20 CRG88490.1 - 1.5e-08 34.2 0.0 2.9e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG88490.1 - 5.8e-08 33.3 0.1 2.8e-07 31.1 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CRG88490.1 - 8.1e-07 29.1 0.1 1.9e-06 27.9 0.1 1.7 1 0 0 1 1 1 1 NACHT domain CMV_1a_C PF12503.8 CRG88490.1 - 2.2e-06 27.6 0.0 5.3 7.1 0.0 6.3 3 2 2 7 7 7 1 Cucumber mosaic virus 1a protein C terminal TPR_14 PF13428.6 CRG88490.1 - 5.1e-05 23.8 6.4 1.2e+02 3.9 0.0 9.2 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88490.1 - 0.00034 20.6 21.1 33 5.0 0.1 10.0 11 0 0 11 11 10 0 Tetratricopeptide repeat ATPase_2 PF01637.18 CRG88490.1 - 0.0011 18.9 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CRG88490.1 - 0.0017 18.6 0.0 0.0047 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Urocanase_N PF17391.2 CRG88490.1 - 0.0082 15.8 0.6 1.4e+02 2.2 0.0 6.0 7 0 0 7 7 7 0 Urocanase N-terminal domain BAP PF06639.11 CRG88490.1 - 0.17 12.2 0.0 1.9e+02 2.4 0.0 4.3 3 2 0 4 4 3 0 Basal layer antifungal peptide (BAP) cwf21 PF08312.12 CRG88490.1 - 0.54 10.5 16.6 42 4.4 0.0 6.3 3 2 0 3 3 3 0 cwf21 domain DAO PF01266.24 CRG88491.1 - 8.7e-35 120.9 0.0 9.9e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG88491.1 - 0.086 13.1 0.2 0.3 11.3 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Glu_dehyd_C PF16912.5 CRG88491.1 - 0.18 11.2 0.0 0.4 10.1 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus Thi4 PF01946.17 CRG88491.1 - 0.22 10.7 0.0 0.48 9.6 0.0 1.5 1 0 0 1 1 1 0 Thi4 family Fungal_trans PF04082.18 CRG88492.1 - 7.4e-09 35.0 0.0 1.3e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF809 PF05663.11 CRG88492.1 - 0.07 13.3 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF809) MFS_1 PF07690.16 CRG88493.1 - 5.8e-26 91.3 32.8 5.8e-26 91.3 32.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG88493.1 - 6e-06 25.4 0.1 1.1e-05 24.5 0.1 1.4 1 1 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 CRG88493.1 - 0.096 12.0 19.6 0.019 14.2 8.0 2.2 2 0 0 2 2 2 0 Uncharacterised MFS-type transporter YbfB AAT PF03417.16 CRG88494.1 - 7e-27 94.6 0.0 8.2e-27 94.4 0.0 1.0 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Sugar_tr PF00083.24 CRG88496.1 - 1.9e-74 251.2 24.3 2.3e-74 250.9 24.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88496.1 - 4.2e-11 42.4 35.1 8.1e-11 41.4 29.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG88496.1 - 3.1e-05 22.7 15.8 0.0034 16.0 5.1 2.6 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 CRG88496.1 - 9.3e-05 21.4 10.2 0.00021 20.3 2.8 2.3 2 0 0 2 2 2 2 MFS_1 like family GLE1 PF07817.13 CRG88496.1 - 0.13 11.5 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 GLE1-like protein ABC_tran PF00005.27 CRG88497.1 - 7.1e-45 152.9 0.1 2.6e-23 83.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG88497.1 - 1.8e-36 126.2 27.0 2.7e-27 96.1 9.7 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 CRG88497.1 - 2.7e-14 53.7 0.1 0.088 12.6 0.0 4.4 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG88497.1 - 4.9e-13 49.0 2.7 0.0011 18.4 0.1 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG88497.1 - 5.7e-06 26.7 0.1 0.048 13.9 0.0 3.3 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.6 CRG88497.1 - 7.9e-06 25.5 2.8 0.06 13.1 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CRG88497.1 - 4.9e-05 23.4 0.0 0.32 11.1 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG88497.1 - 0.0001 22.2 1.1 0.48 10.3 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 CRG88497.1 - 0.00033 20.4 0.6 1.2 8.9 0.1 3.2 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG88497.1 - 0.00078 19.9 0.3 2 8.8 0.0 3.4 4 0 0 4 4 3 1 AAA ATPase domain cobW PF02492.19 CRG88497.1 - 0.0018 17.9 0.4 0.13 11.8 0.1 2.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 CRG88497.1 - 0.0022 17.2 1.0 5.5 6.1 0.0 3.3 3 0 0 3 3 3 1 NB-ARC domain AAA_33 PF13671.6 CRG88497.1 - 0.005 17.0 0.0 3.9 7.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 CRG88497.1 - 0.0085 16.0 0.2 4.6 7.1 0.1 2.8 2 0 0 2 2 2 1 NTPase T2SSE PF00437.20 CRG88497.1 - 0.011 14.9 0.4 0.62 9.1 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 CRG88497.1 - 0.014 15.3 0.8 1.5 8.7 0.0 2.9 3 0 0 3 3 2 0 NACHT domain AAA_18 PF13238.6 CRG88497.1 - 0.028 15.0 0.1 7.2 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG88497.1 - 0.032 14.6 0.0 13 6.2 0.0 2.8 2 0 0 2 2 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 CRG88497.1 - 0.041 13.2 1.9 2.9 7.2 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 CRG88497.1 - 0.042 13.9 0.9 3.8 7.5 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_25 PF13481.6 CRG88497.1 - 0.048 13.2 2.8 14 5.2 0.0 3.6 4 0 0 4 4 4 0 AAA domain IstB_IS21 PF01695.17 CRG88497.1 - 0.049 13.4 4.0 1.3 8.8 0.1 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein ATPase_2 PF01637.18 CRG88497.1 - 0.064 13.2 0.2 0.98 9.3 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea PIF1 PF05970.14 CRG88497.1 - 0.065 12.4 0.0 0.55 9.3 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Roc PF08477.13 CRG88497.1 - 0.082 13.1 0.0 13 6.1 0.0 3.2 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 CRG88497.1 - 0.1 12.3 4.6 1.4 8.6 0.0 2.5 3 0 0 3 3 2 0 AAA ATPase domain AAA_23 PF13476.6 CRG88497.1 - 0.14 12.6 11.6 0.35 11.3 1.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CRG88497.1 - 0.18 11.5 0.3 10 5.8 0.1 2.5 2 1 0 2 2 2 0 AAA domain PNP_UDP_1 PF01048.20 CRG88498.1 - 0.0015 17.8 0.0 0.0037 16.6 0.0 1.6 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG88498.1 - 0.047 14.1 0.0 0.084 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AMP-binding PF00501.28 CRG88500.1 - 1.1e-64 218.6 0.0 1.5e-64 218.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG88500.1 - 1.6e-15 57.8 0.0 3.9e-15 56.6 0.0 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF5357 PF17310.2 CRG88500.1 - 0.15 10.6 0.0 0.45 9.0 0.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5357) Trypan_PARP PF05887.11 CRG88501.1 - 0.0056 16.7 5.0 0.0064 16.5 5.0 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) TPR_12 PF13424.6 CRG88502.1 - 1e-121 397.4 44.8 3.5e-19 68.9 0.5 7.7 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 CRG88502.1 - 1.6e-111 361.6 13.7 2.2e-12 46.4 0.1 10.3 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_1 PF00515.28 CRG88502.1 - 2.2e-52 172.8 36.4 1.6e-05 24.5 0.3 10.0 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88502.1 - 1.7e-42 140.3 12.5 9.8e-05 22.1 0.0 10.5 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88502.1 - 2.4e-42 139.6 27.5 0.00015 21.6 0.5 9.9 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG88502.1 - 1.4e-35 123.2 3.6 3.7e-14 52.9 0.4 3.6 1 1 2 3 3 3 3 MalT-like TPR region TPR_8 PF13181.6 CRG88502.1 - 7.9e-35 116.2 23.8 0.0018 18.4 0.0 9.8 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88502.1 - 1.7e-26 90.7 6.2 0.57 11.2 0.0 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 CRG88502.1 - 2e-15 56.7 0.0 3.4e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily TPR_17 PF13431.6 CRG88502.1 - 2.4e-15 55.7 15.9 2 9.0 0.0 10.9 11 0 0 11 11 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 CRG88502.1 - 1.4e-14 54.5 25.1 0.0025 18.4 0.4 9.1 6 3 1 7 7 6 4 Tetratricopeptide repeat TPR_4 PF07721.14 CRG88502.1 - 8.1e-10 38.4 0.0 34 5.5 0.0 9.2 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88502.1 - 8.8e-10 39.0 26.4 0.0061 17.1 0.7 6.9 3 2 6 9 9 8 7 Tetratricopeptide repeat NB-ARC PF00931.22 CRG88502.1 - 3.2e-09 36.4 0.0 5e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain TPR_21 PF09976.9 CRG88502.1 - 3.4e-09 36.7 25.9 0.44 10.2 0.2 8.9 2 1 3 9 9 9 2 Tetratricopeptide repeat-like domain DUF2225 PF09986.9 CRG88502.1 - 9.3e-09 35.3 7.0 0.022 14.5 0.0 4.7 1 1 1 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2225) PPR PF01535.20 CRG88502.1 - 1e-08 34.9 8.4 0.85 10.0 0.0 8.8 9 0 0 9 9 9 1 PPR repeat TPR_6 PF13174.6 CRG88502.1 - 6e-08 32.8 37.4 0.66 10.7 0.2 9.8 10 0 0 10 10 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 CRG88502.1 - 1.5e-05 24.6 37.9 0.33 10.7 0.1 9.1 9 0 0 9 9 8 3 TPR repeat DUF4810 PF16068.5 CRG88502.1 - 4.2e-05 24.0 23.9 6.3 7.4 1.0 8.5 7 2 1 8 8 8 0 Domain of unknown function (DUF4810) AAA_16 PF13191.6 CRG88502.1 - 0.00096 19.6 0.0 0.0022 18.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain SNAP PF14938.6 CRG88502.1 - 0.0022 17.5 5.8 0.92 8.9 0.6 4.0 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP 14-3-3 PF00244.20 CRG88502.1 - 0.0038 16.7 4.2 6.3 6.2 0.0 4.6 2 2 2 4 4 4 0 14-3-3 protein TPR_3 PF07720.12 CRG88502.1 - 0.0074 16.3 27.5 0.16 12.0 0.3 7.7 8 0 0 8 8 7 2 Tetratricopeptide repeat RPN6_N PF18055.1 CRG88502.1 - 0.0087 16.4 6.7 38 4.7 0.1 5.4 4 1 1 6 6 6 0 26S proteasome regulatory subunit RPN6 N-terminal domain DUF5344 PF17279.2 CRG88502.1 - 0.0098 16.4 4.1 50 4.6 0.0 6.4 6 2 2 8 8 7 0 Family of unknown function (DUF5344) AAA_33 PF13671.6 CRG88502.1 - 0.068 13.3 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 CRG88502.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_22 PF13401.6 CRG88502.1 - 0.14 12.4 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain MIT PF04212.18 CRG88502.1 - 4.8 7.3 19.6 16 5.6 0.0 7.9 9 0 0 9 9 9 0 MIT (microtubule interacting and transport) domain VPS11_C PF12451.8 CRG88502.1 - 4.9 7.5 4.9 89 3.4 0.1 4.0 4 0 0 4 4 4 0 Vacuolar protein sorting protein 11 C terminal RPN6_C_helix PF18503.1 CRG88502.1 - 8.7 6.2 11.4 20 5.1 0.1 5.6 5 0 0 5 5 5 0 26S proteasome subunit RPN6 C-terminal helix domain Glyco_hydro_2_N PF02837.18 CRG88504.1 - 0.029 14.3 0.0 0.031 14.2 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain SEEK1 PF15357.6 CRG88504.1 - 0.2 11.8 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Psoriasis susceptibility 1 candidate 1 Sugar_tr PF00083.24 CRG88506.1 - 2.3e-72 244.3 29.5 2.7e-72 244.1 29.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88506.1 - 1.5e-27 96.5 72.0 1.2e-24 87.0 44.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily SBBP PF06739.11 CRG88506.1 - 0.042 13.9 0.1 5.4 7.1 0.1 2.8 2 0 0 2 2 2 0 Beta-propeller repeat Cellulase PF00150.18 CRG88507.1 - 9e-18 64.7 0.4 1.3e-17 64.2 0.4 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 CRG88507.1 - 0.0013 18.5 0.2 0.0022 17.7 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Glyco_hydro_2_C PF02836.17 CRG88507.1 - 0.0042 16.2 0.1 0.0083 15.3 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Transp_inhibit PF18791.1 CRG88507.1 - 0.035 13.6 0.5 0.1 12.1 0.2 1.9 2 0 0 2 2 2 0 Transport inhibitor response 1 protein domain Glyco_hydro_42 PF02449.15 CRG88507.1 - 0.083 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Beta-galactosidase Fungal_trans PF04082.18 CRG88508.1 - 4.6e-10 39.0 0.2 9.6e-10 37.9 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain AAA_22 PF13401.6 CRG88509.1 - 9.7e-06 25.9 0.0 1.4e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG88509.1 - 3.1e-05 24.4 0.6 0.0003 21.2 0.4 2.2 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 CRG88509.1 - 0.00017 20.9 0.2 0.00022 20.5 0.2 1.1 1 0 0 1 1 1 1 NB-ARC domain ParA PF10609.9 CRG88509.1 - 0.015 14.8 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase SRP54 PF00448.22 CRG88509.1 - 0.018 14.6 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 CRG88509.1 - 0.02 14.8 0.0 0.042 13.8 0.0 1.5 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 CRG88509.1 - 0.04 14.3 0.0 0.06 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 CRG88509.1 - 0.051 13.0 0.1 0.17 11.3 0.0 1.7 2 0 0 2 2 2 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Zot PF05707.12 CRG88509.1 - 0.062 12.9 0.0 0.094 12.3 0.0 1.2 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) TrwB_AAD_bind PF10412.9 CRG88509.1 - 0.1 11.5 0.1 0.15 11.0 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DnaB_C PF03796.15 CRG88509.1 - 0.11 11.8 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain HTH_5 PF01022.20 CRG88510.1 - 0.059 13.3 0.0 0.096 12.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family BAF250_C PF12031.8 CRG88510.1 - 0.093 12.0 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 SWI/SNF-like complex subunit BAF250/Osa MFS_1 PF07690.16 CRG88511.1 - 4.2e-30 104.9 56.4 7.3e-28 97.5 56.4 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG88511.1 - 3.3e-11 42.3 23.3 4.7e-11 41.8 23.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pox_A14 PF05767.12 CRG88511.1 - 0.96 9.6 5.6 2 8.6 4.3 2.3 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF443 PF04276.12 CRG88511.1 - 2.5 7.8 8.3 1.1 9.0 1.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF443) DUF3671 PF12420.8 CRG88511.1 - 5 7.2 6.5 3.6 7.7 0.7 3.2 2 1 1 3 3 3 0 Protein of unknown function ABC_tran PF00005.27 CRG88514.1 - 1.3e-41 142.3 0.3 2.3e-25 89.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG88514.1 - 3.6e-26 92.4 37.4 1.2e-21 77.6 16.8 2.6 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG88514.1 - 4.2e-11 42.7 1.4 0.0017 17.9 0.1 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG88514.1 - 1.5e-10 41.4 3.7 0.043 13.6 0.2 4.3 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG88514.1 - 4.2e-07 29.6 3.1 0.014 15.1 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG88514.1 - 0.00042 20.9 4.2 0.099 13.1 0.1 2.9 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 CRG88514.1 - 0.00057 20.0 1.8 0.075 13.1 0.1 3.0 3 0 0 3 3 3 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 CRG88514.1 - 0.00076 19.6 1.5 1.2 9.2 0.0 2.6 2 0 0 2 2 2 2 Dynamin family AAA_18 PF13238.6 CRG88514.1 - 0.0022 18.5 0.1 0.73 10.4 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_15 PF13175.6 CRG88514.1 - 0.0053 16.5 0.6 0.16 11.7 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_16 PF13191.6 CRG88514.1 - 0.0089 16.4 2.8 2.2 8.6 0.2 2.7 2 1 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CRG88514.1 - 0.01 15.8 2.5 0.69 9.8 0.2 2.4 2 0 0 2 2 2 0 RsgA GTPase ATP-synt_ab PF00006.25 CRG88514.1 - 0.012 15.2 1.6 1.5 8.4 0.1 2.7 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ATP_bind_1 PF03029.17 CRG88514.1 - 0.029 14.1 0.7 0.15 11.9 0.0 2.4 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 CRG88514.1 - 0.079 13.2 3.8 2.9 8.2 0.3 3.2 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 CRG88514.1 - 0.11 11.6 1.2 1.9 7.5 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 CRG88514.1 - 0.14 11.5 1.1 2.1 7.7 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 CRG88514.1 - 0.17 11.2 0.1 1.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin dNK PF01712.19 CRG88514.1 - 0.29 11.0 1.4 9.6 6.0 0.2 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase ABC_ATPase PF09818.9 CRG88514.1 - 0.63 8.8 7.2 0.15 10.8 0.4 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class NACHT PF05729.12 CRG88514.1 - 1.2 9.1 3.9 18 5.2 0.1 2.8 2 0 0 2 2 2 0 NACHT domain DUF3040 PF11239.8 CRG88514.1 - 2.4 8.5 5.6 79 3.6 0.8 4.7 4 0 0 4 4 3 0 Protein of unknown function (DUF3040) Condensation PF00668.20 CRG88515.1 - 1.9e-182 607.0 0.0 2.4e-50 171.6 0.0 7.3 7 0 0 7 7 7 6 Condensation domain AMP-binding PF00501.28 CRG88515.1 - 4.6e-181 602.0 9.4 1.2e-80 271.2 0.5 3.2 3 0 0 3 3 3 3 AMP-binding enzyme PP-binding PF00550.25 CRG88515.1 - 1.8e-18 66.6 0.4 1.7e-10 41.1 0.0 3.0 2 0 0 2 2 2 2 Phosphopantetheine attachment site BH3 PF15285.6 CRG88515.1 - 0.0084 15.9 0.1 7.9 6.4 0.0 2.8 2 0 0 2 2 2 2 Beclin-1 BH3 domain, Bcl-2-interacting Top6b_C PF18000.1 CRG88515.1 - 0.024 14.8 0.0 2.3 8.4 0.0 3.0 2 0 0 2 2 2 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Abhydrolase_8 PF06259.12 CRG88515.1 - 8.6 5.9 7.0 27 4.3 0.3 3.4 4 0 0 4 4 4 0 Alpha/beta hydrolase Sulfotransfer_3 PF13469.6 CRG88516.1 - 1.4e-06 28.9 0.0 3.1e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase family Aminotran_4 PF01063.19 CRG88517.1 - 5.4e-12 46.0 0.0 6.4e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV p450 PF00067.22 CRG88518.1 - 7.6e-74 249.1 0.0 9e-74 248.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Condensation PF00668.20 CRG88519.1 - 9.9e-54 182.7 0.0 1.7e-26 92.9 0.0 2.6 2 1 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CRG88519.1 - 8e-19 67.8 1.0 1.2e-11 44.8 0.1 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding PF00501.28 CRG88519.1 - 0.0003 19.5 0.2 0.00042 19.0 0.2 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG88519.1 - 0.00043 21.2 0.0 0.0011 19.8 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain p450 PF00067.22 CRG88520.1 - 8.2e-59 199.5 0.0 1.1e-58 199.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 M11L PF11099.8 CRG88520.1 - 0.08 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Apoptosis regulator M11L like zf-NADH-PPase PF09297.11 CRG88521.1 - 0.086 12.5 0.5 0.18 11.5 0.5 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain SNF2_N PF00176.23 CRG88522.1 - 8.5e-26 90.5 0.0 2.4e-25 89.0 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG88522.1 - 7.3e-09 36.0 0.0 1.7e-08 34.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88522.1 - 5.3e-06 26.5 0.0 1.6e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit MazE_antitoxin PF04014.18 CRG88522.1 - 0.036 14.0 0.1 0.096 12.6 0.1 1.7 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin RT_RNaseH PF17917.1 CRG88523.1 - 4.8e-37 126.5 0.0 1.1e-36 125.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CRG88523.1 - 9e-32 109.1 0.0 2.5e-31 107.7 0.0 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CRG88523.1 - 2.7e-27 95.8 0.0 4.2e-27 95.1 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-CCHC PF00098.23 CRG88523.1 - 0.0044 17.0 2.3 0.0044 17.0 2.3 2.1 2 0 0 2 2 2 1 Zinc knuckle Asp_protease_2 PF13650.6 CRG88523.1 - 0.0094 16.6 0.1 0.02 15.5 0.1 1.5 1 0 0 1 1 1 1 Aspartyl protease Retrotrans_gag PF03732.17 CRG88523.1 - 0.016 15.5 3.7 0.13 12.6 3.7 2.6 1 1 0 1 1 1 0 Retrotransposon gag protein gag-asp_proteas PF13975.6 CRG88523.1 - 0.039 14.5 0.0 0.097 13.2 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp_protease PF09668.10 CRG88523.1 - 0.045 13.6 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Aspartyl protease zf-CCHC_3 PF13917.6 CRG88523.1 - 0.93 9.5 4.1 0.55 10.2 0.9 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 CRG88523.1 - 9.8 6.0 7.5 0.38 10.5 1.6 1.8 2 0 0 2 2 2 0 C2H2 zinc-finger HMG_box_5 PF14887.6 CRG88524.1 - 0.32 11.0 1.0 19 5.3 0.3 2.2 2 0 0 2 2 2 0 HMG (high mobility group) box 5 DUF5536 PF17688.1 CRG88525.1 - 0.027 14.4 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5536) TPR_2 PF07719.17 CRG88527.1 - 5.1e-13 48.1 8.4 8.3e-05 22.4 0.0 7.2 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 CRG88527.1 - 9e-08 31.6 4.2 0.01 15.6 0.0 6.0 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG88527.1 - 6.4e-05 22.5 0.0 0.00015 21.2 0.0 1.5 1 0 0 1 1 1 1 MalT-like TPR region TPR_8 PF13181.6 CRG88527.1 - 0.00015 21.7 0.3 4.5 7.7 0.1 5.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88527.1 - 0.0004 20.6 0.5 0.45 11.0 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 CRG88527.1 - 0.0024 17.7 8.8 1.2 9.1 0.1 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG88527.1 - 0.0025 18.1 13.3 6.3 7.2 0.4 6.6 6 1 2 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88527.1 - 0.11 12.6 7.9 8.3 6.7 0.0 6.1 8 1 1 9 9 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG88527.1 - 0.11 13.1 21.4 4.8 7.9 2.7 6.4 6 1 1 7 7 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88527.1 - 0.17 12.8 15.7 0.57 11.1 0.1 6.1 7 2 1 8 8 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 CRG88527.1 - 0.37 11.0 2.4 4.1 7.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG88527.1 - 9.1 7.2 21.6 1.6 9.6 1.1 5.2 5 1 1 6 6 5 0 Tetratricopeptide repeat Isochorismatase PF00857.20 CRG88528.1 - 3e-36 125.2 0.0 3.4e-36 125.0 0.0 1.0 1 0 0 1 1 1 1 Isochorismatase family Lactamase_B_2 PF12706.7 CRG88529.1 - 2.7e-14 53.2 1.7 7.6e-14 51.7 1.7 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CRG88529.1 - 8e-11 42.1 0.1 1e-10 41.8 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain PhoD PF09423.10 CRG88529.1 - 0.23 10.4 0.0 6.2 5.7 0.0 2.0 1 1 1 2 2 2 0 PhoD-like phosphatase Ribosomal_S3Ae PF01015.18 CRG88530.1 - 6.6e-88 293.6 3.3 9.3e-88 293.1 3.3 1.2 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 CRG88530.1 - 0.011 16.2 0.1 0.091 13.3 0.0 2.2 2 0 0 2 2 2 0 Translation initiation factor SUI1 NEMO PF11577.8 CRG88530.1 - 0.073 13.1 0.4 0.53 10.3 0.0 2.3 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Elf1 PF05129.13 CRG88531.1 - 9.1e-29 99.3 0.1 1.2e-28 99.0 0.1 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-Sec23_Sec24 PF04810.15 CRG88531.1 - 0.014 15.4 0.9 0.72 9.9 0.2 2.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 CRG88531.1 - 0.028 13.8 0.1 0.051 13.0 0.1 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Zn-ribbon_8 PF09723.10 CRG88531.1 - 0.063 13.4 0.4 0.16 12.1 0.4 1.7 1 1 0 1 1 1 0 Zinc ribbon domain Peptidase_U32 PF01136.19 CRG88531.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.0 1 0 0 1 1 1 0 Peptidase family U32 UPRTase PF14681.6 CRG88532.1 - 2.2e-79 265.7 0.0 2.7e-79 265.4 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 CRG88532.1 - 0.014 14.9 0.0 0.02 14.4 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Flu_C_NS1 PF03506.13 CRG88532.1 - 0.23 11.4 0.2 0.37 10.8 0.2 1.2 1 0 0 1 1 1 0 Influenza C non-structural protein (NS1) WAPL PF07814.13 CRG88533.1 - 7.1e-65 219.2 5.5 1.3e-64 218.4 5.5 1.4 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Ras PF00071.22 CRG88533.1 - 3.3e-39 134.1 0.2 5.5e-39 133.4 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG88533.1 - 1.5e-10 41.3 0.0 2.8e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF383 PF04063.14 CRG88533.1 - 3.1e-05 23.7 0.4 6.1e-05 22.8 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF383) Arf PF00025.21 CRG88533.1 - 0.00049 19.6 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG88533.1 - 0.0081 15.7 0.1 0.016 14.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain tRNA-synt_2b PF00587.25 CRG88534.1 - 5.2e-38 130.8 0.0 1e-37 129.9 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CRG88534.1 - 3.9e-20 72.1 7.0 3.9e-20 72.1 7.0 2.5 3 0 0 3 3 3 1 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 CRG88534.1 - 0.95 8.5 6.7 2.3 7.2 6.7 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cytochrom_C552 PF02335.15 CRG88534.1 - 3 6.6 9.0 1.1 8.1 0.2 2.2 2 0 0 2 2 2 0 Cytochrome c552 2-Hacid_dh_C PF02826.19 CRG88535.1 - 2.7e-53 180.0 0.0 5.4e-53 179.0 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG88535.1 - 7.1e-37 126.1 0.2 1.2e-36 125.3 0.1 1.4 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG88535.1 - 7.2e-05 23.0 0.5 0.0002 21.6 0.4 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 CRG88535.1 - 8.5e-05 22.2 0.0 0.0002 21.1 0.0 1.7 1 0 0 1 1 1 1 ACT domain IlvN PF07991.12 CRG88535.1 - 0.00022 20.8 0.2 0.0086 15.7 0.0 2.4 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 CRG88535.1 - 0.0085 16.2 0.2 0.018 15.1 0.2 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 CRG88535.1 - 0.02 15.4 0.3 0.074 13.6 0.0 2.2 3 0 0 3 3 3 0 XdhC Rossmann domain Oxidored_nitro PF00148.19 CRG88535.1 - 0.034 12.9 0.0 0.045 12.5 0.0 1.3 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase DUF1780 PF08682.10 CRG88535.1 - 0.092 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative endonuclease, protein of unknown function (DUF1780) 3HCDH_N PF02737.18 CRG88535.1 - 0.17 11.8 0.6 1 9.2 0.5 2.3 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 CRG88536.1 - 1.5e-65 221.2 0.0 1.9e-65 220.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88536.1 - 3.2e-31 108.6 0.0 4.7e-31 108.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG88536.1 - 0.00011 21.7 0.2 0.00052 19.4 0.3 2.1 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 CRG88536.1 - 0.0039 16.2 0.0 0.0069 15.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 CRG88536.1 - 0.045 13.4 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 RIO1 family FTA2 PF13095.6 CRG88536.1 - 0.19 11.3 0.1 6.3 6.4 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 P5-ATPase PF12409.8 CRG88537.1 - 3.4e-39 133.8 0.0 7.4e-39 132.7 0.0 1.6 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 CRG88537.1 - 3e-31 108.4 0.5 7.3e-31 107.1 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 CRG88537.1 - 5.5e-16 59.5 0.2 6.3e-07 29.9 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG88537.1 - 0.00043 19.9 0.0 0.00091 18.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 CRG88537.1 - 0.0015 18.6 0.0 0.0032 17.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 CRG88537.1 - 0.23 11.2 0.0 9 6.0 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Myosin_head PF00063.21 CRG88538.1 - 1.6e-264 879.3 1.6 2.3e-264 878.8 1.6 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) NAP PF00956.18 CRG88538.1 - 3e-97 325.0 11.0 3e-97 325.0 11.0 2.8 4 0 0 4 4 2 1 Nucleosome assembly protein (NAP) DIL PF01843.19 CRG88538.1 - 3.3e-26 91.6 2.7 3.3e-26 91.6 2.7 2.6 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 CRG88538.1 - 7.6e-11 40.8 29.1 0.00084 18.9 0.8 5.8 5 0 0 5 5 5 4 IQ calmodulin-binding motif Myosin_N PF02736.19 CRG88538.1 - 0.00028 20.6 1.1 0.00028 20.6 1.1 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain AAA_16 PF13191.6 CRG88538.1 - 0.0044 17.4 0.4 0.019 15.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CRG88538.1 - 0.0084 16.0 0.0 0.027 14.4 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 CRG88538.1 - 0.023 15.0 1.6 0.052 13.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 CRG88538.1 - 0.2 11.4 1.1 22 4.8 0.0 3.0 3 0 0 3 3 3 0 DEAD/DEAH box helicase Noelin-1 PF12308.8 CRG88538.1 - 0.25 11.3 1.6 1 9.4 1.6 2.1 1 0 0 1 1 1 0 Neurogenesis glycoprotein Osteopontin PF00865.18 CRG88538.1 - 8.7 5.7 22.6 6.4 6.2 20.1 2.0 2 0 0 2 2 2 0 Osteopontin Ham1p_like PF01725.16 CRG88539.1 - 1.2e-55 188.4 0.0 1.3e-55 188.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family AAA_18 PF13238.6 CRG88540.1 - 2.1e-23 83.3 0.0 3.7e-23 82.5 0.0 1.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CRG88540.1 - 0.0022 18.4 0.0 0.01 16.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 CRG88540.1 - 0.016 15.5 0.0 0.04 14.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG88540.1 - 0.03 14.7 0.0 0.049 14.0 0.0 1.3 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 CRG88540.1 - 0.031 14.2 0.1 0.064 13.2 0.1 1.5 1 0 0 1 1 1 0 NTPase AAA_17 PF13207.6 CRG88540.1 - 0.044 14.2 0.1 0.38 11.2 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 CRG88540.1 - 0.095 12.7 0.0 0.2 11.7 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 CRG88540.1 - 0.11 12.8 0.1 0.26 11.5 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CRG88540.1 - 0.12 12.8 0.1 0.19 12.1 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 CRG88540.1 - 0.17 12.1 0.0 0.34 11.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain Peptidase_C78 PF07910.13 CRG88541.1 - 4.7e-68 228.8 0.0 6.7e-68 228.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C78 zf-Di19 PF05605.12 CRG88541.1 - 0.0026 18.0 8.0 0.0028 17.9 1.4 3.0 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 CRG88541.1 - 0.0049 16.4 0.2 0.014 15.0 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger AA_kinase PF00696.28 CRG88542.1 - 1.5e-41 142.6 0.1 2.1e-41 142.1 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT_7 PF13840.6 CRG88542.1 - 4e-13 49.0 1.0 4.6e-11 42.3 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 CRG88542.1 - 4.9e-11 42.2 1.6 3.9e-08 32.9 0.1 3.5 3 0 0 3 3 3 2 ACT domain Forkhead PF00250.18 CRG88543.1 - 7.4e-35 119.1 0.0 1.4e-34 118.2 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain SAB PF04382.13 CRG88543.1 - 0.026 14.6 0.3 0.075 13.1 0.3 1.8 1 0 0 1 1 1 0 SAB domain G10 PF01125.17 CRG88544.1 - 1.5e-41 141.6 1.0 1.8e-41 141.3 1.0 1.0 1 0 0 1 1 1 1 G10 protein Ribosomal_L23eN PF03939.13 CRG88545.1 - 2.7e-24 85.1 6.6 2.7e-24 85.1 6.6 1.7 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 CRG88545.1 - 1.3e-16 60.7 1.0 2.4e-16 59.9 1.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 Bmt2 PF11968.8 CRG88546.1 - 2.5e-89 298.9 0.0 3.3e-89 298.5 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Aa_trans PF01490.18 CRG88547.1 - 6.9e-67 225.9 24.7 8.2e-67 225.7 24.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MerC PF03203.14 CRG88547.1 - 0.015 15.8 1.5 0.015 15.8 1.5 3.2 3 2 1 4 4 4 0 MerC mercury resistance protein eRF1_2 PF03464.15 CRG88548.1 - 3.4e-47 160.1 0.1 5.7e-47 159.4 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 CRG88548.1 - 8.8e-39 132.5 0.7 2.1e-38 131.3 0.7 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 CRG88548.1 - 1.8e-21 76.4 0.0 4.4e-21 75.2 0.0 1.7 2 0 0 2 2 2 1 eRF1 domain 1 baeRF_family10 PF18854.1 CRG88548.1 - 4e-10 40.1 0.0 7.1e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 CRG88548.1 - 9.7e-09 35.6 0.1 1.6e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor Ribosomal_L7Ae PF01248.26 CRG88548.1 - 0.062 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PDT PF00800.18 CRG88549.1 - 4.3e-64 215.7 0.1 6.4e-64 215.1 0.1 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 CRG88549.1 - 1.1e-06 28.3 0.0 5.2e-05 22.9 0.0 2.5 2 0 0 2 2 2 1 ACT domain DER1 PF04511.15 CRG88550.1 - 6.2e-29 101.3 3.6 9e-29 100.8 3.6 1.2 1 0 0 1 1 1 1 Der1-like family MaoC_dehydratas PF01575.19 CRG88550.1 - 0.084 12.4 0.1 0.29 10.7 0.0 1.8 2 0 0 2 2 2 0 MaoC like domain DKCLD PF08068.12 CRG88551.1 - 1.1e-33 115.1 1.0 2.5e-32 110.7 0.1 2.9 3 0 0 3 3 3 1 DKCLD (NUC011) domain TruB_N PF01509.18 CRG88551.1 - 2.4e-23 83.1 0.2 2.1e-20 73.6 0.2 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 CRG88551.1 - 2.8e-23 81.8 1.6 5e-23 81.0 1.6 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 CRG88551.1 - 5.7e-22 77.5 1.3 1e-21 76.7 1.3 1.4 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 CRG88551.1 - 0.0027 17.9 0.0 0.0069 16.6 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain CLTH PF10607.9 CRG88552.1 - 3.5e-34 117.8 0.2 5.8e-34 117.1 0.2 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain COX16 PF14138.6 CRG88552.1 - 0.017 15.6 0.6 0.043 14.3 0.6 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 DNA_meth_N PF18284.1 CRG88552.1 - 0.044 13.7 0.0 0.16 11.9 0.0 2.0 1 0 0 1 1 1 0 DNA methylase N-terminal domain LisH PF08513.11 CRG88552.1 - 0.055 13.5 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 LisH zf-Di19 PF05605.12 CRG88552.1 - 0.11 12.8 1.3 0.19 12.1 0.2 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF2431 PF10354.9 CRG88553.1 - 6.7e-61 205.4 0.0 9.6e-61 204.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) EamA PF00892.20 CRG88554.1 - 4.2e-06 27.0 7.7 4.2e-06 27.0 7.7 2.3 2 0 0 2 2 2 1 EamA-like transporter family UPF0370 PF13980.6 CRG88554.1 - 0.15 12.1 0.0 0.44 10.6 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) PHO4 PF01384.20 CRG88554.1 - 5.8 5.9 19.1 0.082 11.9 7.2 2.3 1 1 1 2 2 2 0 Phosphate transporter family Thioredoxin PF00085.20 CRG88555.1 - 0.00022 21.2 0.0 0.00038 20.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin SMI1_KNR4 PF09346.10 CRG88556.1 - 8.7e-34 116.8 0.0 1.7e-33 115.8 0.0 1.5 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) PNRC PF15365.6 CRG88557.1 - 1e-08 34.7 8.7 1e-08 34.7 8.7 3.3 3 0 0 3 3 3 1 Proline-rich nuclear receptor coactivator motif zf-rbx1 PF12678.7 CRG88558.1 - 4e-25 87.9 12.8 5.6e-25 87.4 12.8 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 CRG88558.1 - 3.6e-17 62.2 10.0 4.7e-17 61.8 10.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 CRG88558.1 - 2.9e-06 27.5 14.8 0.0001 22.6 14.8 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG88558.1 - 9.4e-05 22.2 3.7 9.4e-05 22.2 3.7 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG88558.1 - 0.0016 18.3 11.9 0.028 14.3 11.9 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 CRG88558.1 - 0.2 11.9 9.1 0.88 9.8 9.2 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 CRG88558.1 - 0.28 11.1 10.6 0.67 9.9 4.3 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CRG88558.1 - 0.64 9.7 14.6 0.11 12.1 4.6 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 CRG88558.1 - 0.65 10.1 8.3 2.5 8.2 8.3 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 CRG88558.1 - 1.1 9.1 17.1 99 2.8 17.1 2.5 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 CRG88558.1 - 9.3 6.3 11.4 51 3.9 11.4 2.3 1 1 0 1 1 1 0 zinc-RING finger domain SPC12 PF06645.13 CRG88559.1 - 3.1e-30 104.1 1.4 3.8e-30 103.8 1.4 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) ZYG-11_interact PF05884.12 CRG88559.1 - 0.024 14.1 0.1 0.025 14.0 0.1 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF3040 PF11239.8 CRG88559.1 - 0.05 13.9 0.4 0.073 13.4 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) PBD PF00786.28 CRG88560.1 - 0.024 15.0 0.6 0.077 13.4 0.6 1.9 1 0 0 1 1 1 0 P21-Rho-binding domain Es2 PF09751.9 CRG88561.1 - 1.5e-135 453.3 11.5 1.8e-135 453.0 11.5 1.1 1 0 0 1 1 1 1 Nuclear protein Es2 Mid1 PF12929.7 CRG88562.1 - 6e-159 529.8 7.6 6.9e-159 529.6 7.6 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 CRG88562.1 - 0.0025 18.4 5.7 0.062 13.9 2.0 2.4 2 0 0 2 2 2 2 Fz domain Viral_NABP PF05515.11 CRG88562.1 - 0.099 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Viral nucleic acid binding NB-ARC PF00931.22 CRG88563.1 - 1.4e-09 37.5 0.0 2e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain TPR_MalT PF17874.1 CRG88563.1 - 0.0026 17.2 0.2 0.0026 17.2 0.2 1.6 2 0 0 2 2 2 1 MalT-like TPR region ATPase_2 PF01637.18 CRG88563.1 - 0.0057 16.6 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea TniB PF05621.11 CRG88563.1 - 0.0075 15.7 0.0 0.018 14.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein TPR_2 PF07719.17 CRG88563.1 - 0.021 14.9 7.4 0.06 13.5 1.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat ATPase PF06745.13 CRG88563.1 - 0.023 14.1 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 CRG88563.1 - 0.027 14.9 0.0 0.067 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain CorA PF01544.18 CRG88564.1 - 3.6e-40 138.1 0.0 5.1e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein GHMP_kinases_N PF00288.26 CRG88565.1 - 5.2e-11 42.6 0.0 9.6e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CRG88565.1 - 5.6e-05 23.4 0.0 0.00012 22.4 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal Acyltransferase PF01553.21 CRG88566.1 - 1.3e-26 92.8 0.0 2.8e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase TPR_2 PF07719.17 CRG88566.1 - 2.6e-21 73.9 30.5 0.0058 16.7 0.0 12.2 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 CRG88566.1 - 3.5e-21 74.1 27.6 0.002 17.8 0.1 11.6 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88566.1 - 2.2e-14 53.7 26.8 0.0044 17.5 0.3 9.1 8 3 2 11 11 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88566.1 - 4.2e-13 48.4 29.5 0.049 13.9 0.2 11.2 13 0 0 13 13 10 5 Tetratricopeptide repeat Acyltransf_C PF16076.5 CRG88566.1 - 1.4e-12 47.5 0.5 6e-12 45.5 0.0 2.4 2 0 0 2 2 2 1 Acyltransferase C-terminus TPR_12 PF13424.6 CRG88566.1 - 7.8e-11 42.1 22.9 0.066 13.5 0.1 9.5 8 2 2 11 11 11 2 Tetratricopeptide repeat TPR_6 PF13174.6 CRG88566.1 - 3.9e-10 39.7 20.5 0.07 13.8 0.1 11.6 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 CRG88566.1 - 1.5e-07 31.9 25.6 0.0075 16.9 0.1 8.1 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88566.1 - 1.6e-07 31.5 30.3 0.11 13.3 0.0 10.3 9 1 3 12 12 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 CRG88566.1 - 2e-07 30.6 10.1 1.5 8.6 0.1 8.4 8 1 1 9 9 9 3 TPR repeat TPR_7 PF13176.6 CRG88566.1 - 9e-05 22.2 19.9 0.78 9.9 0.1 8.4 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88566.1 - 0.00037 20.7 14.8 8.1 7.1 0.1 7.8 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG88566.1 - 0.0019 18.0 19.9 1.4 8.9 0.0 8.4 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_4 PF07721.14 CRG88566.1 - 0.082 13.6 0.0 12 6.9 0.0 3.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG88566.1 - 0.12 12.6 13.0 3.4 8.0 0.1 5.2 5 0 0 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 CRG88566.1 - 0.15 12.1 12.5 2.9 8.0 0.1 5.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TFIIA PF03153.13 CRG88566.1 - 0.61 10.0 28.4 0.012 15.6 21.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit NAD_kinase PF01513.21 CRG88567.1 - 1.2e-46 159.2 0.0 1.6e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase RsgI_N PF12791.7 CRG88567.1 - 0.028 14.3 0.8 0.46 10.4 0.1 2.6 3 0 0 3 3 3 0 Anti-sigma factor N-terminus Pkinase PF00069.25 CRG88568.1 - 1.3e-67 228.0 0.8 1.3e-66 224.7 0.8 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88568.1 - 4.5e-51 173.6 0.0 8.4e-51 172.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 CRG88568.1 - 2.7e-24 85.3 0.1 8.8e-23 80.4 0.0 2.7 2 0 0 2 2 2 1 P21-Rho-binding domain PH_11 PF15413.6 CRG88568.1 - 2e-15 57.1 0.1 5.6e-15 55.6 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Kinase-like PF14531.6 CRG88568.1 - 7.7e-06 25.4 0.0 1.3e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CRG88568.1 - 4.1e-05 22.7 0.2 8.3e-05 21.7 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 CRG88568.1 - 7.1e-05 21.8 0.0 7.1e-05 21.8 0.0 2.5 2 1 0 2 2 1 1 Fungal protein kinase PH PF00169.29 CRG88568.1 - 0.00051 20.5 0.1 0.0013 19.2 0.1 1.8 1 0 0 1 1 1 1 PH domain Seadorna_VP7 PF07387.11 CRG88568.1 - 0.01 14.9 0.1 0.018 14.1 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 KIND PF16474.5 CRG88568.1 - 0.14 12.0 0.0 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain Inhibitor_I34 PF10466.9 CRG88568.1 - 2 9.0 6.6 7 7.3 1.5 2.7 2 0 0 2 2 2 0 Saccharopepsin inhibitor I34 APH PF01636.23 CRG88568.1 - 2.8 7.8 5.8 0.4 10.6 0.2 2.2 2 1 1 3 3 2 0 Phosphotransferase enzyme family HGTP_anticodon PF03129.20 CRG88570.1 - 5.1e-22 77.8 2.2 9.2e-22 77.0 0.0 2.6 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CRG88570.1 - 1.3e-08 35.0 0.0 6.2e-08 32.8 0.0 2.1 3 0 0 3 3 3 1 tRNA synthetase class II core domain (G, H, P, S and T) Brix PF04427.18 CRG88571.1 - 2.4e-23 83.2 0.0 3.8e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 Brix domain BUD22 PF09073.10 CRG88571.1 - 0.044 13.1 21.2 0.061 12.7 21.2 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 CRG88571.1 - 0.91 7.7 22.8 1.2 7.3 22.8 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 CRG88571.1 - 1.9 6.9 9.4 2.7 6.5 9.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 CRG88571.1 - 3.6 6.8 13.6 5.5 6.2 13.6 1.4 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.11 CRG88571.1 - 8.5 4.3 10.5 15 3.5 10.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Hid1 PF12722.7 CRG88571.1 - 8.7 4.3 6.7 11 3.9 6.7 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Methyltransf_23 PF13489.6 CRG88572.1 - 4e-11 43.0 0.0 7.2e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88572.1 - 4.1e-09 36.4 0.0 1.5e-08 34.6 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG88572.1 - 2.7e-05 24.8 0.0 6e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG88572.1 - 0.003 17.1 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 CRG88572.1 - 0.017 15.9 0.0 0.068 13.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CRG88572.1 - 0.18 11.3 0.0 0.39 10.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Pept_tRNA_hydro PF01195.19 CRG88573.1 - 1.1e-20 74.3 0.0 5.3e-13 49.3 0.0 2.5 2 1 0 2 2 2 2 Peptidyl-tRNA hydrolase BAR PF03114.18 CRG88574.1 - 7.2e-62 209.1 3.9 8.7e-62 208.9 3.9 1.1 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 CRG88574.1 - 0.0073 17.0 0.0 0.058 14.2 0.0 2.5 1 1 0 2 2 2 1 CP12 domain BAR_3 PF16746.5 CRG88574.1 - 0.018 14.7 0.2 0.038 13.7 0.2 1.4 1 1 0 1 1 1 0 BAR domain of APPL family BAR_2 PF10455.9 CRG88574.1 - 0.28 10.3 3.9 2.4 7.2 3.9 2.1 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking Jnk-SapK_ap_N PF09744.9 CRG88574.1 - 0.35 11.1 7.3 1.5 9.0 1.7 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Pkinase PF00069.25 CRG88575.1 - 1.1e-48 165.9 0.0 1.6e-48 165.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88575.1 - 1.7e-27 96.3 0.0 2.3e-27 95.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CRG88575.1 - 0.0043 16.4 0.0 0.0084 15.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CRG88575.1 - 0.0082 15.5 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 CRG88575.1 - 0.056 13.3 1.1 1.9 8.3 0.0 2.9 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sybindin PF04099.12 CRG88576.1 - 8e-25 87.4 0.0 1.1e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CRG88576.1 - 0.048 13.8 0.1 0.069 13.3 0.1 1.2 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Pkinase PF00069.25 CRG88577.1 - 6.8e-55 186.3 0.0 1.9e-48 165.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88577.1 - 8e-34 117.1 0.0 1.1e-31 110.0 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CRG88577.1 - 9e-07 28.5 0.0 1.2e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CRG88577.1 - 0.0056 16.6 0.0 0.022 14.7 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG88577.1 - 0.095 11.5 0.1 0.29 9.9 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Myb_DNA-binding PF00249.31 CRG88578.1 - 0.059 13.6 0.0 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Myb-like DNA-binding domain eIF-6 PF01912.18 CRG88579.1 - 1.1e-77 259.9 0.5 2.3e-77 258.8 0.4 1.6 2 0 0 2 2 2 1 eIF-6 family SRI PF08236.11 CRG88579.1 - 6.4e-21 74.3 14.5 1.8e-20 72.9 14.5 1.8 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 CRG88579.1 - 2.7e-16 60.4 0.4 2.7e-16 60.4 0.4 3.3 3 2 0 3 3 3 1 SET domain AWS PF17907.1 CRG88579.1 - 2.4e-11 43.5 11.1 2.4e-11 43.5 11.1 2.5 2 0 0 2 2 2 1 AWS domain XPC-binding PF09280.11 CRG88581.1 - 9.4e-25 86.1 17.9 1.6e-24 85.4 17.9 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 CRG88581.1 - 6.9e-23 80.2 3.1 2.7e-12 46.4 0.1 2.4 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 CRG88581.1 - 1.1e-20 73.1 0.4 2.1e-20 72.2 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CRG88581.1 - 2.7e-08 33.5 0.4 5.1e-08 32.6 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 CRG88581.1 - 0.003 17.9 0.4 0.0056 17.0 0.4 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CRG88581.1 - 0.008 16.3 0.1 0.017 15.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA_3 PF09288.10 CRG88581.1 - 0.04 13.7 0.0 2.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Ubiquitin_2 PF14560.6 CRG88581.1 - 0.053 14.0 0.1 0.11 13.0 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 CRG88581.1 - 0.071 13.7 0.0 0.15 12.7 0.0 1.5 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain CCDC53 PF10152.9 CRG88581.1 - 0.8 10.1 5.9 15 5.9 0.1 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Skp1 PF01466.19 CRG88582.1 - 1.1e-28 99.1 0.2 1.7e-28 98.4 0.2 1.3 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 CRG88582.1 - 3.8e-22 78.2 0.2 8.9e-22 77.0 0.1 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Glyco_transf_22 PF03901.17 CRG88583.1 - 6.6e-52 177.1 17.8 2.4e-31 109.4 5.1 2.1 1 1 1 2 2 2 2 Alg9-like mannosyltransferase family CoA_binding PF02629.19 CRG88584.1 - 2.3e-26 92.3 3.1 3e-26 91.9 1.0 2.1 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 CRG88584.1 - 5.2e-23 81.6 0.3 8.2e-23 80.9 0.3 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 CRG88584.1 - 3.1e-08 33.5 0.0 5.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 CRG88584.1 - 0.00046 20.7 0.1 0.001 19.5 0.1 1.6 1 0 0 1 1 1 1 CoA binding domain ThiF PF00899.21 CRG88586.1 - 9.6e-30 103.7 0.0 1.3e-29 103.2 0.0 1.1 1 0 0 1 1 1 1 ThiF family Ytp1 PF10355.9 CRG88587.1 - 9.7e-67 225.1 20.5 9.7e-67 225.1 20.5 2.7 2 1 0 2 2 2 2 Protein of unknown function (Ytp1) DUF2427 PF10348.9 CRG88587.1 - 2.5e-31 107.6 1.6 2.5e-31 107.6 1.6 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Swi5 PF07061.11 CRG88588.1 - 1.1e-24 86.3 0.5 2.9e-24 85.0 0.5 1.6 1 1 0 1 1 1 1 Swi5 TMF_DNA_bd PF12329.8 CRG88588.1 - 0.037 14.0 4.3 0.059 13.4 4.3 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF3287 PF11690.8 CRG88588.1 - 0.037 13.8 0.7 0.053 13.2 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) GPS2_interact PF15784.5 CRG88588.1 - 0.052 14.0 1.9 0.078 13.4 1.9 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Seryl_tRNA_N PF02403.22 CRG88588.1 - 0.057 13.7 0.8 0.089 13.0 0.8 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.11 CRG88588.1 - 0.071 13.4 0.4 0.1 12.8 0.4 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Prefoldin_2 PF01920.20 CRG88588.1 - 0.072 13.1 2.7 0.1 12.6 2.7 1.2 1 0 0 1 1 1 0 Prefoldin subunit Bombinin PF05298.11 CRG88588.1 - 0.073 12.7 0.0 0.12 12.0 0.0 1.4 1 1 0 1 1 1 0 Bombinin DUF1824 PF08854.10 CRG88588.1 - 0.082 12.8 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1824) PspA_IM30 PF04012.12 CRG88588.1 - 0.2 11.2 3.7 0.28 10.7 3.7 1.1 1 0 0 1 1 1 0 PspA/IM30 family ABC_membrane PF00664.23 CRG88589.1 - 1.4e-107 359.4 37.3 5.8e-55 186.9 17.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG88589.1 - 6.8e-68 227.4 0.0 4e-33 114.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG88589.1 - 7.3e-14 51.7 0.0 0.00026 20.5 0.0 3.6 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG88589.1 - 4.2e-07 30.5 1.7 0.035 14.5 0.5 3.5 2 2 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CRG88589.1 - 5.3e-07 29.3 1.1 0.0021 17.7 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 CRG88589.1 - 3.5e-06 26.1 0.8 0.0076 15.1 0.0 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 CRG88589.1 - 7.3e-06 26.0 0.0 0.15 11.9 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_21 PF13304.6 CRG88589.1 - 2e-05 24.6 1.2 0.22 11.3 0.0 3.5 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CRG88589.1 - 5.1e-05 23.6 0.6 0.57 10.4 0.0 3.8 4 0 0 4 4 3 2 AAA domain AAA_30 PF13604.6 CRG88589.1 - 5.2e-05 23.0 0.9 0.59 9.8 0.0 3.7 4 0 0 4 4 4 2 AAA domain AAA PF00004.29 CRG88589.1 - 5.5e-05 23.6 0.5 4.9 7.6 0.1 4.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CRG88589.1 - 0.00014 21.5 2.9 0.11 12.1 0.0 3.7 4 0 0 4 4 4 1 AAA domain AAA_7 PF12775.7 CRG88589.1 - 0.0011 18.6 0.0 1.3 8.5 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_15 PF13175.6 CRG88589.1 - 0.0011 18.8 1.6 1.7 8.3 0.0 3.0 2 1 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 CRG88589.1 - 0.004 17.4 0.1 0.6 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CRG88589.1 - 0.0052 16.2 0.0 1.5 8.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CRG88589.1 - 0.008 16.2 0.2 7.2 6.6 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 CRG88589.1 - 0.0083 15.3 0.0 3.7 6.6 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Rad17 PF03215.15 CRG88589.1 - 0.012 15.6 0.1 0.85 9.5 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_18 PF13238.6 CRG88589.1 - 0.013 16.1 0.0 11 6.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CRG88589.1 - 0.013 15.6 0.1 6.2 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 CRG88589.1 - 0.029 14.0 0.1 4.1 7.0 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 CRG88589.1 - 0.039 13.2 0.1 2.5 7.3 0.0 2.8 3 0 0 3 3 2 0 Zeta toxin DUF87 PF01935.17 CRG88589.1 - 0.064 13.3 0.0 11 6.1 0.0 2.8 2 0 0 2 2 2 0 Helicase HerA, central domain SbcCD_C PF13558.6 CRG88589.1 - 0.081 13.2 7.1 4.5 7.6 0.6 4.0 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_24 PF13479.6 CRG88589.1 - 0.094 12.4 0.1 12 5.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG88589.1 - 0.098 13.1 0.1 13 6.3 0.0 2.9 2 0 0 2 2 2 0 RNA helicase MMR_HSR1 PF01926.23 CRG88589.1 - 0.19 11.8 0.8 19 5.3 0.0 2.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 CRG88589.1 - 0.41 11.1 8.3 1.1 9.8 0.5 3.4 3 0 0 3 3 3 0 AAA domain RFX_DNA_binding PF02257.15 CRG88590.1 - 2.5e-28 98.5 0.1 1.1e-27 96.5 0.2 2.1 2 0 0 2 2 2 1 RFX DNA-binding domain Ribosomal_L39 PF00832.20 CRG88590.1 - 2.1e-11 43.2 1.5 4e-11 42.4 1.5 1.4 1 0 0 1 1 1 1 Ribosomal L39 protein Radical_SAM_C PF16199.5 CRG88591.1 - 1e-32 112.0 0.0 2.1e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 CRG88591.1 - 1.6e-20 74.2 0.0 1e-19 71.5 0.0 2.2 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 CRG88591.1 - 5e-10 39.6 0.0 9.7e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG88591.1 - 7e-06 26.0 0.0 2.1e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG88591.1 - 0.12 12.8 0.1 0.28 11.6 0.1 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AP_endonuc_2 PF01261.24 CRG88591.1 - 0.14 11.6 0.0 0.3 10.5 0.0 1.6 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel FR47 PF08445.10 CRG88591.1 - 0.18 11.8 0.0 0.45 10.5 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Oxidored_q6 PF01058.22 CRG88592.1 - 1.5e-23 83.1 0.0 1.9e-23 82.7 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit His_biosynth PF00977.21 CRG88594.1 - 7.2e-34 117.2 0.0 9.9e-34 116.8 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein DUF4602 PF15375.6 CRG88595.1 - 5.6e-12 46.1 23.6 3.6e-11 43.5 23.6 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) STE PF02200.16 CRG88596.1 - 4.1e-56 188.1 0.0 6.4e-56 187.5 0.0 1.3 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 CRG88596.1 - 1.8e-11 43.8 10.7 4.9e-07 29.8 0.9 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG88596.1 - 6.1e-09 35.9 4.1 6.1e-09 35.9 4.1 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG88596.1 - 2.7e-08 34.0 8.5 0.0002 21.9 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CRG88596.1 - 8e-05 22.5 0.2 8e-05 22.5 0.2 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG88596.1 - 0.0025 18.0 0.2 0.041 14.2 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding NOA36 PF06524.12 CRG88596.1 - 0.0059 16.0 1.2 0.0093 15.3 1.2 1.2 1 0 0 1 1 1 1 NOA36 protein zinc_ribbon_9 PF14369.6 CRG88596.1 - 0.084 13.1 0.2 0.22 11.8 0.2 1.7 1 0 0 1 1 1 0 zinc-ribbon FYDLN_acid PF09538.10 CRG88596.1 - 0.14 12.8 0.5 0.37 11.5 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-TRAF PF02176.18 CRG88596.1 - 0.16 12.7 2.6 0.28 11.9 2.6 1.4 1 0 0 1 1 1 0 TRAF-type zinc finger zf-Di19 PF05605.12 CRG88596.1 - 0.4 11.0 4.0 0.21 11.9 0.4 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 CRG88596.1 - 1.6 8.7 5.3 2.3 8.2 0.3 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 CRG88596.1 - 8.5 6.2 10.0 23 4.9 0.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Na_H_Exchanger PF00999.21 CRG88597.1 - 1.3e-70 238.1 38.5 1.3e-70 238.1 38.5 2.8 3 0 0 3 3 3 1 Sodium/hydrogen exchanger family MFS_2 PF13347.6 CRG88597.1 - 7.7e-10 37.9 2.8 7.7e-10 37.9 2.8 4.0 4 0 0 4 4 4 1 MFS/sugar transport protein SNF2_N PF00176.23 CRG88598.1 - 6.6e-65 219.1 1.1 2e-64 217.5 0.9 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 CRG88598.1 - 1.1e-48 165.0 23.1 1.1e-48 165.0 23.1 4.5 5 1 0 5 5 5 1 DNA-binding domain Helicase_C PF00271.31 CRG88598.1 - 1.9e-19 70.0 0.0 6.1e-19 68.4 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88598.1 - 6.4e-07 29.5 3.0 7.3e-06 26.1 0.0 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CRG88598.1 - 0.0021 17.9 0.0 0.0094 15.7 0.0 2.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 CRG88598.1 - 0.0022 17.2 0.6 0.012 14.8 0.0 2.6 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 Fe_hyd_lg_C PF02906.14 CRG88598.1 - 0.93 9.1 7.4 0.029 14.0 1.0 1.7 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain Aminotran_1_2 PF00155.21 CRG88599.1 - 6.4e-85 285.5 0.0 8.2e-85 285.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CRG88599.1 - 1.2e-06 27.7 0.0 2.6e-06 26.6 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CRG88599.1 - 2.1e-05 23.3 0.0 3.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CRG88599.1 - 0.00084 18.7 0.1 0.0017 17.7 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pkinase PF00069.25 CRG88600.1 - 8.9e-14 51.5 0.0 1.6e-13 50.6 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88600.1 - 8.9e-10 38.3 0.0 8.1e-09 35.1 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 CRG88600.1 - 0.00011 22.3 0.3 0.0027 17.7 0.6 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG88600.1 - 0.0064 15.9 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CRG88600.1 - 0.015 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 CRG88600.1 - 0.032 13.8 0.0 0.46 10.0 0.0 2.0 1 1 1 2 2 2 0 Choline/ethanolamine kinase TB2_DP1_HVA22 PF03134.19 CRG88601.1 - 1.4e-27 95.4 8.9 1.4e-27 95.4 8.9 1.6 1 1 1 2 2 2 2 TB2/DP1, HVA22 family ATG101 PF07855.12 CRG88602.1 - 1.4e-54 184.2 0.0 1.6e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 101 Peroxin-3 PF04882.12 CRG88603.1 - 1.5e-166 555.1 0.2 2.2e-166 554.5 0.2 1.2 1 0 0 1 1 1 1 Peroxin-3 RNA_pol_I_A49 PF06870.12 CRG88604.1 - 8.8e-76 255.3 0.0 1.1e-75 254.9 0.0 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor MFS_1 PF07690.16 CRG88605.1 - 9.3e-35 120.2 26.2 9.3e-35 120.2 26.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Ribosomal_L41 PF05162.13 CRG88605.1 - 2.8e-09 36.9 26.2 5.2e-09 36.0 26.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L41 DUF4337 PF14235.6 CRG88605.1 - 0.18 11.9 1.4 1.1 9.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Peptidase_A8 PF01252.18 CRG88605.1 - 8.9 6.6 9.1 9.3 6.5 0.9 2.9 2 2 0 2 2 2 0 Signal peptidase (SPase) II Ysc84 PF04366.12 CRG88606.1 - 3.1e-45 153.0 0.2 4.8e-45 152.4 0.2 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator BNIP2 PF12496.8 CRG88606.1 - 1.8 9.0 9.4 0.33 11.4 1.0 2.8 3 0 0 3 3 3 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 ETF PF01012.21 CRG88607.1 - 1.6e-43 148.7 0.3 1.9e-43 148.5 0.3 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain PIG-X PF08320.12 CRG88608.1 - 3.7e-69 232.9 0.0 5.7e-69 232.3 0.0 1.3 1 0 0 1 1 1 1 PIG-X / PBN1 DnaJ_C PF01556.18 CRG88608.1 - 6.1e-32 110.8 0.7 9.9e-32 110.1 0.7 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CRG88608.1 - 2.7e-27 94.7 6.3 1.7e-26 92.1 6.4 2.1 2 0 0 2 2 2 1 DnaJ domain SAYSvFN PF10260.9 CRG88608.1 - 0.19 11.7 0.1 0.59 10.1 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized conserved domain (SAYSvFN) GATase PF00117.28 CRG88609.1 - 5.4e-47 160.0 0.0 7.2e-47 159.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 CRG88609.1 - 3.5e-45 153.0 0.0 6.6e-45 152.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 CRG88609.1 - 8.6e-06 25.7 0.5 0.00013 21.8 0.5 2.3 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 CRG88609.1 - 0.018 14.9 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family SNF2_N PF00176.23 CRG88610.1 - 2.8e-44 151.3 0.0 7.5e-44 149.9 0.0 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG88610.1 - 2.7e-18 66.3 0.0 7.1e-18 65.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88610.1 - 0.0001 22.4 0.0 0.00037 20.5 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 CRG88610.1 - 0.00016 21.4 0.0 0.1 12.3 0.0 2.7 2 0 0 2 2 2 2 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 CRG88610.1 - 0.0022 17.2 0.0 0.005 16.1 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase GSH_synth_ATP PF03917.17 CRG88611.1 - 1.4e-136 455.2 0.0 1.6e-136 455.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 CRG88611.1 - 1e-27 96.6 0.0 1.7e-27 95.8 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase RPN13_C PF16550.5 CRG88611.1 - 0.005 17.0 0.0 0.02 15.0 0.0 2.0 2 0 0 2 2 2 1 UCH-binding domain Sugar_tr PF00083.24 CRG88612.1 - 6.6e-94 315.3 15.4 8.4e-94 315.0 15.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88612.1 - 1.2e-14 54.1 43.4 7e-08 31.8 34.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PEP_hydrolase PF09370.10 CRG88612.1 - 0.21 10.8 0.4 0.34 10.1 0.4 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate hydrolase-like Bestrophin PF01062.21 CRG88613.1 - 9.6e-34 117.1 0.0 1.8e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel T6SS_VasE PF05936.12 CRG88613.1 - 0.018 13.7 0.0 0.027 13.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE YL1_C PF08265.11 CRG88614.1 - 9.4e-17 60.5 0.4 1.5e-16 59.9 0.4 1.3 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Got1 PF04178.12 CRG88615.1 - 2.3e-13 50.5 13.8 3e-13 50.2 13.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family DUF443 PF04276.12 CRG88615.1 - 3.1 7.5 10.1 5.7 6.7 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF443) Ank_2 PF12796.7 CRG88616.1 - 8.7e-39 132.0 0.7 7.8e-13 48.8 0.0 6.3 1 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG88616.1 - 4.9e-35 115.6 0.2 0.00079 19.7 0.0 11.5 12 0 0 12 12 11 5 Ankyrin repeat Ank_4 PF13637.6 CRG88616.1 - 1.7e-31 108.2 1.2 1.1e-07 32.3 0.0 8.8 3 3 5 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG88616.1 - 4e-24 84.4 0.7 1.8e-05 24.9 0.4 8.8 7 2 2 9 9 9 5 Ankyrin repeats (many copies) Ank PF00023.30 CRG88616.1 - 2.2e-23 81.6 1.1 0.0032 17.8 0.0 9.7 10 0 0 10 10 9 5 Ankyrin repeat NACHT PF05729.12 CRG88616.1 - 4.4e-10 39.7 0.0 1e-09 38.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Helo_like_N PF17111.5 CRG88616.1 - 3.5e-06 26.5 1.7 5.1e-06 26.0 0.1 2.1 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins AAA_22 PF13401.6 CRG88616.1 - 0.00046 20.5 0.0 0.0024 18.2 0.0 2.3 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CRG88616.1 - 0.0012 18.9 1.5 0.08 13.0 1.5 2.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG88616.1 - 0.0015 18.9 0.0 0.008 16.6 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 CRG88616.1 - 0.0086 15.3 0.2 0.034 13.3 0.2 2.0 1 1 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 CRG88616.1 - 0.15 11.9 1.4 0.25 11.2 0.1 2.0 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea DUF1987 PF09345.10 CRG88616.1 - 0.17 11.6 0.5 0.62 9.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) Profilin PF00235.19 CRG88617.1 - 2.3e-30 105.4 0.2 2.6e-30 105.3 0.2 1.0 1 0 0 1 1 1 1 Profilin DUF5053 PF16476.5 CRG88617.1 - 0.036 13.7 0.1 0.37 10.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5053) Sec63 PF02889.16 CRG88619.1 - 7.3e-136 451.3 0.0 2e-79 266.4 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CRG88619.1 - 2.8e-52 177.0 0.4 2.1e-26 92.8 0.5 3.1 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 CRG88619.1 - 1.4e-22 80.5 0.0 1.4e-10 41.4 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG88619.1 - 4.6e-17 62.4 0.0 8.9e-07 29.2 0.0 4.6 4 2 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 CRG88619.1 - 1.2e-07 32.0 0.4 0.0019 18.5 0.0 3.6 2 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CRG88619.1 - 1.5e-07 31.3 0.1 0.0073 16.0 0.2 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CRG88619.1 - 1.3e-05 25.6 0.6 0.0072 16.7 0.4 2.7 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CRG88619.1 - 0.014 14.5 0.0 3.5 6.6 0.0 2.6 2 0 0 2 2 2 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 CRG88619.1 - 0.021 14.5 0.1 6.3 6.5 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein Helicase_PWI PF18149.1 CRG88619.1 - 0.061 13.5 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 N-terminal helicase PWI domain DUF4603 PF15376.6 CRG88619.1 - 0.12 9.8 0.6 0.16 9.3 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) TniB PF05621.11 CRG88619.1 - 0.13 11.7 1.0 17 4.8 0.1 3.4 3 0 0 3 3 3 0 Bacterial TniB protein Synaptobrevin PF00957.21 CRG88620.1 - 2.2e-14 53.0 0.6 4.4e-14 52.0 0.6 1.5 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 CRG88620.1 - 2.2e-14 53.2 0.0 5e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain DNA_binding_1 PF01035.20 CRG88621.1 - 2.2e-23 82.1 0.0 3e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF4224 PF13986.6 CRG88621.1 - 0.02 14.8 0.0 1.4 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4224) Bud13 PF09736.9 CRG88622.1 - 2.8e-49 167.3 7.1 2.8e-49 167.3 7.1 2.8 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Nop16 PF09420.10 CRG88622.1 - 0.19 11.7 9.2 0.029 14.4 3.0 2.1 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 Pkinase PF00069.25 CRG88623.1 - 3.7e-40 138.0 0.0 8.1e-22 77.8 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88623.1 - 1.1e-13 51.1 0.1 1e-09 38.1 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG88623.1 - 0.064 12.0 1.0 0.067 12.0 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase Metallophos PF00149.28 CRG88624.1 - 6.3e-11 43.2 1.9 1e-10 42.5 1.9 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG88624.1 - 2.6e-05 24.5 0.8 0.00026 21.2 0.2 2.3 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain FMN_dh PF01070.18 CRG88625.1 - 2.2e-124 415.0 0.3 2.7e-124 414.7 0.3 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG88625.1 - 6.3e-23 80.7 0.1 1.3e-22 79.8 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 CRG88625.1 - 1.5e-07 30.9 0.0 2.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG88625.1 - 9.1e-05 21.6 0.5 0.00018 20.6 0.1 1.7 2 1 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CRG88625.1 - 0.00041 19.9 0.1 0.00058 19.3 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 CRG88625.1 - 0.0084 15.6 0.8 0.44 10.0 0.1 2.4 1 1 0 2 2 2 1 Histidine biosynthesis protein G3P_antiterm PF04309.12 CRG88625.1 - 0.043 13.2 0.0 7.3 6.0 0.0 2.5 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator ThiG PF05690.14 CRG88625.1 - 0.089 12.1 0.1 2.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG Glu_syn_central PF04898.14 CRG88625.1 - 0.15 11.5 0.0 0.41 10.1 0.0 1.6 2 0 0 2 2 2 0 Glutamate synthase central domain Ras PF00071.22 CRG88626.1 - 6.9e-42 142.8 0.0 5.5e-41 139.9 0.0 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CRG88626.1 - 5.7e-33 113.7 0.0 8.7e-33 113.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG88626.1 - 1.7e-12 47.2 0.0 3e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CRG88626.1 - 2.4e-06 27.6 0.2 4.9e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG88626.1 - 0.00012 22.5 0.0 0.00027 21.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 CRG88626.1 - 0.0025 17.3 0.0 0.0035 16.8 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 CRG88626.1 - 0.0039 16.6 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 CRG88626.1 - 0.0055 17.0 0.0 0.023 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CRG88626.1 - 0.0081 16.1 0.0 0.019 14.8 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 CRG88626.1 - 0.015 15.4 0.0 0.03 14.4 0.0 1.5 1 0 0 1 1 1 0 Dynamin family AAA_24 PF13479.6 CRG88626.1 - 0.042 13.6 0.1 0.095 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CRG88626.1 - 0.048 13.2 0.1 0.079 12.5 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 CRG88626.1 - 0.088 13.0 0.2 0.16 12.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CRG88626.1 - 0.099 12.7 0.0 0.25 11.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain DLIC PF05783.11 CRG88626.1 - 0.16 10.8 0.0 0.28 10.0 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Brr6_like_C_C PF10104.9 CRG88628.1 - 6.1e-39 132.8 1.4 8.4e-39 132.4 1.4 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Ank_4 PF13637.6 CRG88629.1 - 1.9e-44 149.5 5.0 2.1e-08 34.6 0.1 8.3 2 1 6 8 8 8 7 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG88629.1 - 9.1e-41 138.3 0.1 1.1e-16 61.1 0.1 4.8 1 1 0 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 CRG88629.1 - 4.7e-37 124.8 0.4 1.7e-06 28.2 0.2 8.2 8 0 0 8 8 8 7 Ankyrin repeat Ank_3 PF13606.6 CRG88629.1 - 1.3e-29 98.9 0.0 0.0084 16.5 0.0 8.7 9 0 0 9 9 7 7 Ankyrin repeat Ank_5 PF13857.6 CRG88629.1 - 8.9e-29 99.2 0.7 1e-06 28.9 0.1 6.1 3 2 3 7 7 7 6 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 CRG88629.1 - 2.8e-09 36.6 0.0 5e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG88629.1 - 1.2e-05 25.2 0.1 8.9e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 CRG88629.1 - 4.8e-05 23.8 0.4 0.00033 21.1 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CRG88629.1 - 0.004 17.4 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain MTTB PF06253.11 CRG88629.1 - 0.097 10.6 0.1 0.15 10.0 0.1 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) RNA_helicase PF00910.22 CRG88629.1 - 0.16 12.4 0.0 0.48 10.8 0.0 1.9 1 0 0 1 1 1 0 RNA helicase KAP_NTPase PF07693.14 CRG88629.1 - 0.27 10.4 2.8 4.1 6.6 0.2 2.3 1 1 1 2 2 2 0 KAP family P-loop domain Glyco_hydro_cc PF11790.8 CRG88630.1 - 4.4e-43 147.6 1.5 5e-43 147.4 1.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Fungal_trans PF04082.18 CRG88631.1 - 9.9e-14 51.0 0.1 1.7e-13 50.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88631.1 - 2.1e-07 30.9 11.1 3.6e-07 30.2 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_4 PF01063.19 CRG88632.1 - 3.4e-38 131.7 0.0 4.1e-38 131.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Glyco_transf_20 PF00982.21 CRG88633.1 - 5.3e-164 546.4 0.0 6.2e-164 546.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 CRG88633.1 - 0.0073 15.9 0.1 0.053 13.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG88633.1 - 0.047 14.1 0.0 0.086 13.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 CRG88633.1 - 0.076 13.4 0.5 0.24 11.8 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferases group 1 SUZ PF12752.7 CRG88633.1 - 6.8 7.5 8.3 36 5.2 0.0 2.5 2 1 0 2 2 2 0 SUZ domain Anoctamin PF04547.12 CRG88634.1 - 1.4e-111 373.6 7.6 1.7e-111 373.3 7.6 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel MASE1 PF05231.14 CRG88634.1 - 0.025 13.8 4.8 0.045 12.9 4.8 1.4 1 0 0 1 1 1 0 MASE1 GRIP PF01465.20 CRG88635.1 - 3.7e-16 58.8 0.4 9.4e-16 57.5 0.4 1.7 1 0 0 1 1 1 1 GRIP domain Acetyltransf_1 PF00583.25 CRG88635.1 - 4e-14 52.9 0.0 1e-13 51.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family GAS PF13851.6 CRG88635.1 - 4.1e-09 36.1 151.6 2e-06 27.3 19.5 10.9 2 2 9 11 11 11 6 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CRG88635.1 - 3.5e-08 32.7 153.1 0.00061 18.8 15.5 8.4 2 2 6 8 8 8 5 Spc7 kinetochore protein FR47 PF08445.10 CRG88635.1 - 4.2e-07 29.9 0.0 3.6e-06 26.9 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.7 CRG88635.1 - 5.7e-06 26.7 0.0 1.3e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TPR_MLP1_2 PF07926.12 CRG88635.1 - 4.4e-05 23.6 159.6 0.01 15.9 9.7 10.3 4 3 5 9 9 9 5 TPR/MLP1/MLP2-like protein Acetyltransf_10 PF13673.7 CRG88635.1 - 0.00018 21.4 0.0 0.00098 19.1 0.0 2.3 2 0 0 2 2 1 1 Acetyltransferase (GNAT) domain ATG16 PF08614.11 CRG88635.1 - 0.00022 21.5 172.7 0.016 15.4 19.2 9.1 2 2 6 9 9 9 5 Autophagy protein 16 (ATG16) Acetyltransf_3 PF13302.7 CRG88635.1 - 0.00036 21.2 0.0 0.011 16.4 0.0 3.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Tropomyosin_1 PF12718.7 CRG88635.1 - 0.0004 20.6 24.0 0.0004 20.6 24.0 9.0 3 2 4 7 7 6 2 Tropomyosin like CENP-F_leu_zip PF10473.9 CRG88635.1 - 0.00068 19.7 16.0 0.00068 19.7 16.0 9.4 3 2 6 9 9 9 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.11 CRG88635.1 - 0.00074 18.5 154.4 0.0016 17.4 26.4 6.6 2 2 2 4 4 4 3 Calcium binding and coiled-coil domain (CALCOCO1) like FPP PF05911.11 CRG88635.1 - 0.01 14.1 145.5 0.023 12.9 23.4 6.3 2 2 4 6 6 6 0 Filament-like plant protein, long coiled-coil Cep57_CLD_2 PF14197.6 CRG88635.1 - 0.011 15.8 1.9 0.011 15.8 1.9 12.5 7 3 4 11 11 8 0 Centrosome localisation domain of PPC89 DivIC PF04977.15 CRG88635.1 - 0.049 13.4 0.2 0.049 13.4 0.2 14.9 6 4 9 16 16 16 0 Septum formation initiator KASH_CCD PF14662.6 CRG88635.1 - 0.25 11.2 143.8 0.031 14.1 26.8 6.8 2 2 4 6 6 6 0 Coiled-coil region of CCDC155 or KASH DUF812 PF05667.11 CRG88635.1 - 0.25 10.2 145.0 0.015 14.2 48.6 5.7 1 1 4 5 5 5 0 Protein of unknown function (DUF812) Fez1 PF06818.15 CRG88635.1 - 0.65 10.4 147.6 5.4 7.4 13.1 8.2 2 2 5 7 7 6 0 Fez1 Fib_alpha PF08702.10 CRG88635.1 - 1.8 8.7 95.9 3.4 7.8 9.3 8.7 2 2 7 9 9 9 0 Fibrinogen alpha/beta chain family Filament PF00038.21 CRG88635.1 - 5.4 6.5 136.1 0.59 9.7 20.1 7.4 2 2 2 4 4 3 0 Intermediate filament protein zinc_ribbon_10 PF10058.9 CRG88636.1 - 1.2e-20 73.0 0.2 2.1e-20 72.2 0.2 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein MARVEL PF01284.23 CRG88637.1 - 2.9e-14 53.3 11.0 3.6e-14 53.0 11.0 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF5504 PF17608.2 CRG88637.1 - 3.2e-05 24.0 0.7 5.3e-05 23.3 0.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5504) DUF202 PF02656.15 CRG88637.1 - 0.21 12.1 1.9 0.99 9.9 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) PrgI PF12666.7 CRG88637.1 - 2.1 9.1 7.1 0.38 11.5 2.6 1.9 1 1 1 2 2 2 0 PrgI family protein cNMP_binding PF00027.29 CRG88638.1 - 3.7e-30 103.8 0.8 2.2e-19 69.3 0.0 5.5 6 0 0 6 6 6 4 Cyclic nucleotide-binding domain Patatin PF01734.22 CRG88638.1 - 1.1e-17 64.9 7.0 1.3e-12 48.3 3.4 3.1 3 0 0 3 3 3 2 Patatin-like phospholipase DUF3611 PF12263.8 CRG88638.1 - 0.29 11.0 3.8 0.58 10.0 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) Glyco_hydro_1 PF00232.18 CRG88639.1 - 2.7e-73 247.0 0.5 7.9e-40 136.6 0.2 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 1 Med17 PF10156.9 CRG88640.1 - 2.1e-107 359.7 0.3 2.9e-107 359.3 0.3 1.1 1 0 0 1 1 1 1 Subunit 17 of Mediator complex DUF4355 PF14265.6 CRG88640.1 - 0.017 15.3 7.6 0.039 14.2 7.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) CdiI_2 PF18593.1 CRG88640.1 - 0.22 12.2 1.4 0.85 10.3 1.4 2.0 1 0 0 1 1 1 0 CdiI immunity protein ISN1 PF06437.11 CRG88641.1 - 5.3e-197 654.7 0.0 5.9e-197 654.5 0.0 1.0 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase DUF4646 PF15496.6 CRG88642.1 - 6.4e-10 39.7 0.1 3.5e-09 37.3 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4646) Erf4 PF10256.9 CRG88642.1 - 0.094 12.8 0.0 0.2 11.7 0.0 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family adh_short_C2 PF13561.6 CRG88643.1 - 4.2e-43 147.6 0.1 4.9e-43 147.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG88643.1 - 6.2e-38 130.2 0.2 7.2e-38 130.0 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG88643.1 - 2.5e-13 50.3 0.2 3e-13 50.1 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG88643.1 - 0.00074 19.1 0.1 0.001 18.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG88643.1 - 0.018 14.5 0.1 0.031 13.7 0.1 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG88643.1 - 0.024 13.7 0.2 0.047 12.8 0.2 1.5 1 1 0 1 1 1 0 RmlD substrate binding domain ThiF PF00899.21 CRG88643.1 - 0.13 11.6 1.9 8.3 5.7 0.1 2.2 1 1 1 2 2 2 0 ThiF family PFK PF00365.20 CRG88645.1 - 1.3e-189 628.4 0.6 3.4e-103 344.9 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase Glyco_hydro_76 PF03663.14 CRG88645.1 - 1.2e-163 544.9 25.1 1.6e-163 544.5 25.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DAGK_cat PF00781.24 CRG88645.1 - 0.12 12.0 0.1 0.44 10.2 0.1 1.9 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain YkyA PF10368.9 CRG88645.1 - 0.21 11.2 1.1 0.38 10.4 0.5 1.6 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein GREB1 PF15782.5 CRG88647.1 - 0.28 8.3 0.8 0.27 8.3 0.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SNF2_N PF00176.23 CRG88649.1 - 3.2e-65 220.1 0.0 4.7e-65 219.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 CRG88649.1 - 8e-19 67.4 0.0 1.8e-18 66.2 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 CRG88649.1 - 8.1e-15 55.1 0.0 1.7e-14 54.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 CRG88649.1 - 7.5e-10 38.5 7.6 1.7e-09 37.4 7.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG88649.1 - 6.6e-09 36.0 7.0 6.6e-09 36.0 7.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 CRG88649.1 - 3.8e-08 33.0 6.1 3.8e-08 33.0 6.1 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG88649.1 - 9.3e-08 31.8 7.8 9.3e-08 31.8 7.8 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CRG88649.1 - 1.4e-07 31.7 4.5 3.4e-07 30.5 4.5 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CRG88649.1 - 8.8e-07 28.8 2.8 1.9e-06 27.8 2.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-Nse PF11789.8 CRG88649.1 - 1e-05 25.3 5.7 1.4e-05 24.9 4.5 1.8 2 0 0 2 2 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_5 PF14634.6 CRG88649.1 - 1.3e-05 25.1 6.2 2.5e-05 24.1 6.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CRG88649.1 - 1.7e-05 24.9 5.6 3e-05 24.1 5.6 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 CRG88649.1 - 0.00016 21.3 1.8 0.00065 19.4 1.5 2.3 2 0 0 2 2 2 1 RING-like zinc finger Prok-RING_4 PF14447.6 CRG88649.1 - 0.00026 20.8 5.6 0.00026 20.8 5.6 1.7 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 U-box PF04564.15 CRG88649.1 - 0.0014 18.8 0.0 0.0046 17.1 0.0 1.9 1 0 0 1 1 1 1 U-box domain zf-ANAPC11 PF12861.7 CRG88649.1 - 0.0028 17.7 0.9 0.0061 16.6 0.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 CRG88649.1 - 0.048 13.5 1.0 0.11 12.4 1.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 CRG88649.1 - 1.2 9.0 5.0 2.3 8.1 5.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 CRG88649.1 - 2 8.6 5.8 1.2 9.3 3.2 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 MMR_HSR1_Xtn PF16897.5 CRG88650.1 - 2.2e-34 117.7 2.3 1.5e-33 115.0 0.6 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 CRG88650.1 - 2.8e-21 75.3 0.1 5.3e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 CRG88650.1 - 1.1e-20 73.8 0.0 2.5e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG88650.1 - 2.6e-13 49.8 0.0 4.4e-13 49.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 CRG88650.1 - 0.00029 20.9 1.1 0.28 11.2 0.0 2.6 2 1 1 3 3 3 2 Dynamin family MeaB PF03308.16 CRG88650.1 - 0.061 12.3 0.1 0.15 11.0 0.1 1.7 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 CRG88650.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 AIG1 family MCM PF00493.23 CRG88650.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain Torus PF16131.5 CRG88651.1 - 3.4e-46 156.4 2.7 1.2e-45 154.6 0.1 2.5 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 CRG88651.1 - 7.7e-08 32.1 0.0 1.4e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 CRG88651.1 - 0.0011 18.9 1.2 0.0011 18.9 1.2 1.8 2 0 0 2 2 2 1 Zinc finger domain Alpha_Helical PF18489.1 CRG88651.1 - 0.047 13.9 0.1 0.083 13.1 0.1 1.3 1 0 0 1 1 1 0 Alpha helical domain Nup35_RRM_2 PF14605.6 CRG88651.1 - 0.053 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 CRG88651.1 - 0.12 12.3 1.8 0.21 11.5 1.8 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 CRG88651.1 - 0.86 9.5 3.9 1.7 8.5 3.9 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger HGTP_anticodon2 PF12745.7 CRG88652.1 - 2.1e-81 273.3 0.3 2.1e-81 273.3 0.3 2.0 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 CRG88652.1 - 2.2e-71 240.3 0.0 7.4e-36 123.9 0.0 3.6 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88652.1 - 2.2e-39 135.3 0.0 5.4e-18 65.2 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 CRG88652.1 - 1.3e-17 64.1 0.1 4.2e-17 62.5 0.1 2.0 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 CRG88652.1 - 8.5e-14 51.5 0.9 3.2e-13 49.6 0.0 2.1 2 0 0 2 2 2 1 Histidyl-tRNA synthetase Kinase-like PF14531.6 CRG88652.1 - 0.0015 17.9 0.1 0.23 10.8 0.0 3.0 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 CRG88652.1 - 0.0035 17.3 3.2 0.0061 16.5 0.0 2.7 3 0 0 3 3 3 1 Phosphotransferase enzyme family HGTP_anticodon PF03129.20 CRG88652.1 - 0.007 16.5 0.0 0.026 14.7 0.0 2.0 1 0 0 1 1 1 1 Anticodon binding domain HIF-1a_CTAD PF08778.10 CRG88652.1 - 0.12 12.0 0.1 0.31 10.7 0.1 1.7 1 0 0 1 1 1 0 HIF-1 alpha C terminal transactivation domain Cut12 PF11500.8 CRG88653.1 - 2.9e-46 157.0 7.7 2.9e-46 157.0 7.7 3.9 3 1 1 4 4 4 1 Spindle pole body formation-associated protein GIT_CC PF16559.5 CRG88653.1 - 0.0029 17.4 1.4 0.014 15.2 1.4 2.2 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 CRG88653.1 - 0.055 13.8 0.7 0.055 13.8 0.7 3.2 3 1 1 4 4 4 0 TSC-22/dip/bun family BLOC1_2 PF10046.9 CRG88653.1 - 2.2 8.7 14.9 4.5 7.6 1.6 3.5 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF89 PF01937.19 CRG88654.1 - 8.8e-128 426.2 0.1 1.3e-118 396.0 0.1 2.0 2 0 0 2 2 2 2 Protein of unknown function DUF89 Cytochrom_C550 PF14495.6 CRG88654.1 - 0.052 13.3 0.0 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 Cytochrome c-550 domain PPP5 PF08321.12 CRG88655.1 - 4.6e-33 113.4 0.7 1.2e-32 112.1 0.3 1.8 2 0 0 2 2 2 1 PPP5 TPR repeat region Metallophos PF00149.28 CRG88655.1 - 1.7e-31 110.4 0.1 2.4e-31 109.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 CRG88655.1 - 4.4e-12 45.3 0.2 8.4e-05 22.2 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88655.1 - 1.9e-08 33.8 0.9 0.012 15.7 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG88655.1 - 1.8e-07 30.7 0.3 0.034 13.8 0.2 3.2 3 0 0 3 3 3 2 TPR repeat TPR_16 PF13432.6 CRG88655.1 - 4.2e-06 27.3 2.7 0.2 12.3 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88655.1 - 1.3e-05 25.6 0.1 0.22 12.1 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG88655.1 - 0.00034 20.7 0.1 0.013 15.6 0.1 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 CRG88655.1 - 0.0018 18.8 0.3 0.46 11.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88655.1 - 0.003 17.6 0.1 0.43 10.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88655.1 - 0.0034 17.7 0.7 6.5 7.4 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88655.1 - 0.0085 16.8 0.9 1.3 10.1 0.1 3.5 1 1 2 3 3 3 1 Tetratricopeptide repeat DUF2683 PF10884.8 CRG88655.1 - 0.056 13.7 0.2 0.41 10.9 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2683) Spt4 PF06093.13 CRG88656.1 - 1.8e-32 111.2 0.3 2.2e-32 111.0 0.3 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger TackOD1 PF18551.1 CRG88656.1 - 0.029 14.0 1.1 0.039 13.6 1.1 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 Zn_ribbon_17 PF17120.5 CRG88656.1 - 0.34 10.6 3.0 0.69 9.6 3.0 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Aminotran_3 PF00202.21 CRG88657.1 - 2.9e-123 411.5 0.0 3.6e-123 411.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DUF1656 PF07869.12 CRG88657.1 - 6.6 6.8 6.6 1.6 8.8 1.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1656) DASH_Dad4 PF08650.10 CRG88658.1 - 6.1e-32 109.4 7.5 6.7e-32 109.3 7.5 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 GM_CSF PF01109.17 CRG88658.1 - 0.031 14.4 0.3 0.035 14.3 0.3 1.1 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor Actin PF00022.19 CRG88659.1 - 6.7e-54 183.0 0.0 6.4e-30 104.1 0.0 2.3 1 1 1 2 2 2 2 Actin FUSC-like PF12805.7 CRG88659.1 - 0.18 10.9 1.9 0.41 9.7 1.9 1.5 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS bZIP_1 PF00170.21 CRG88660.1 - 1.7e-10 40.9 5.3 3.3e-10 39.9 5.3 1.5 1 0 0 1 1 1 1 bZIP transcription factor DUF3972 PF13118.6 CRG88660.1 - 0.031 14.7 0.1 0.13 12.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) dsrm PF00035.26 CRG88660.1 - 0.14 12.9 0.2 0.32 11.7 0.2 1.7 1 0 0 1 1 1 0 Double-stranded RNA binding motif bZIP_2 PF07716.15 CRG88660.1 - 0.46 10.6 12.2 0.85 9.8 7.9 2.6 2 1 0 2 2 2 0 Basic region leucine zipper tRNA-synt_1c PF00749.21 CRG88662.1 - 8e-97 323.9 0.1 1.2e-96 323.3 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 CRG88662.1 - 5.6e-32 111.0 0.0 4.4e-31 108.1 0.0 2.3 3 0 0 3 3 3 1 tRNA synthetases class I (E and Q), anti-codon binding domain MFS_1 PF07690.16 CRG88663.1 - 3.3e-10 39.4 11.7 4.7e-10 38.9 11.2 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4499 PF14934.6 CRG88663.1 - 0.017 15.4 3.8 5.6 7.4 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4499) CBM_2 PF00553.19 CRG88663.1 - 0.087 13.1 0.6 0.19 12.0 0.6 1.5 1 0 0 1 1 1 0 Cellulose binding domain Pectate_lyase_3 PF12708.7 CRG88664.1 - 9.4e-50 169.4 11.3 1.7e-42 145.7 3.3 2.6 2 1 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CRG88664.1 - 9.1e-05 22.1 1.0 0.17 11.6 0.1 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase zf-C2H2_4 PF13894.6 CRG88665.1 - 2e-06 28.2 2.7 0.0019 18.9 0.1 2.9 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG88665.1 - 3.2e-05 24.1 10.5 0.00034 20.9 0.3 4.0 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 CRG88665.1 - 0.0011 18.7 0.3 0.0032 17.2 0.3 1.8 1 0 0 1 1 1 1 zinc-finger C2H2-type UPF0547 PF10571.9 CRG88665.1 - 0.026 14.6 0.3 0.045 13.8 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 HCNGP PF07818.13 CRG88665.1 - 0.036 14.7 0.0 0.06 14.0 0.0 1.4 1 0 0 1 1 1 0 HCNGP-like protein zf-Di19 PF05605.12 CRG88665.1 - 0.048 14.0 3.5 4.8 7.6 3.8 2.4 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 CRG88665.1 - 0.19 12.0 1.4 0.46 10.8 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon Prok-RING_1 PF14446.6 CRG88665.1 - 0.24 11.3 2.1 4.1 7.4 0.2 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-C2H2_12 PF18112.1 CRG88665.1 - 0.41 11.1 3.0 15 6.1 0.0 3.0 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Zn-ribbon_8 PF09723.10 CRG88665.1 - 0.64 10.2 3.2 0.49 10.6 0.4 2.1 1 1 1 2 2 2 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 CRG88665.1 - 0.7 9.9 2.7 3.8 7.5 2.7 2.0 1 1 1 2 2 2 0 zinc-ribbon domain zf-HYPF PF07503.12 CRG88665.1 - 1.6 8.6 4.2 1.1 9.1 0.7 2.5 2 1 1 3 3 3 0 HypF finger Glyco_hydro_cc PF11790.8 CRG88666.1 - 1.7e-58 198.0 6.0 2.1e-58 197.7 6.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_31 PF01055.26 CRG88668.1 - 4.3e-111 372.2 3.3 5.4e-111 371.9 3.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CRG88668.1 - 1.8e-17 63.4 0.5 1.1e-16 60.9 0.2 2.6 3 0 0 3 3 3 1 Galactose mutarotase-like Sugar_tr PF00083.24 CRG88669.1 - 9.5e-97 324.7 24.8 1.1e-96 324.5 24.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88669.1 - 4.6e-27 94.9 20.4 4.6e-27 94.9 20.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG88669.1 - 4.2e-06 25.5 1.5 4.2e-06 25.5 1.5 1.7 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Methyltransf_PK PF05891.12 CRG88669.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Glyco_hydro_3 PF00933.21 CRG88670.1 - 3.9e-60 203.9 0.0 5.4e-60 203.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CRG88670.1 - 1.6e-53 181.7 0.1 2.7e-53 181.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CRG88670.1 - 1.6e-20 73.0 0.0 3.7e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain Sugar-bind PF04198.13 CRG88670.1 - 0.067 12.3 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative sugar-binding domain Glyco_hydro_12 PF01670.16 CRG88671.1 - 4.5e-45 154.2 7.3 5.2e-45 154.0 7.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Sterol_MT_C PF08498.10 CRG88673.1 - 9.1e-29 99.6 0.1 1.5e-28 98.9 0.1 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 CRG88673.1 - 4.5e-22 78.5 0.0 8.1e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG88673.1 - 6.2e-20 71.7 0.0 1.5e-19 70.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88673.1 - 3.3e-18 65.9 0.0 4.9e-18 65.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CRG88673.1 - 2.3e-14 53.3 0.0 3.5e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CRG88673.1 - 1.6e-12 47.6 0.0 2.5e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG88673.1 - 4.7e-11 42.5 0.0 7.7e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG88673.1 - 1.1e-10 42.2 0.0 2.4e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 CRG88673.1 - 2e-06 26.6 0.0 2.8e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PCMT PF01135.19 CRG88673.1 - 0.00014 21.7 0.0 0.00021 21.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 CRG88673.1 - 0.0011 18.3 0.0 0.0018 17.6 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain PrmA PF06325.13 CRG88673.1 - 0.0043 16.5 0.0 0.0077 15.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 CRG88673.1 - 0.012 15.2 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 CRG88673.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 CRG88673.1 - 0.023 14.3 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase TehB PF03848.14 CRG88673.1 - 0.026 13.9 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB MetW PF07021.12 CRG88673.1 - 0.034 13.7 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 CRG88673.1 - 0.039 13.8 0.0 0.17 11.7 0.0 1.8 2 0 0 2 2 2 0 Hypothetical methyltransferase UPF0020 PF01170.18 CRG88673.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 RRM_1 PF00076.22 CRG88674.1 - 5.5e-09 35.7 0.0 9.6e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG88674.1 - 0.0052 16.8 0.0 0.0088 16.0 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Complex1_LYR PF05347.15 CRG88675.1 - 1.4e-06 28.2 0.7 2.9e-06 27.2 0.2 1.7 2 0 0 2 2 2 1 Complex 1 protein (LYR family) MOSC PF03473.17 CRG88675.1 - 0.089 12.8 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 MOSC domain Complex1_LYR_2 PF13233.6 CRG88675.1 - 0.15 12.8 0.6 0.19 12.5 0.6 1.4 1 1 0 1 1 1 0 Complex1_LYR-like RAC_head PF16717.5 CRG88676.1 - 1.4e-29 102.9 6.2 1.4e-29 102.9 6.2 3.1 2 1 0 2 2 2 1 Ribosome-associated complex head domain DnaJ PF00226.31 CRG88676.1 - 1.5e-17 63.5 1.0 1.5e-17 63.5 1.0 2.6 3 0 0 3 3 3 1 DnaJ domain Aldo_ket_red PF00248.21 CRG88677.1 - 8.5e-71 238.5 0.1 1.1e-70 238.2 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SnoaL PF07366.12 CRG88678.1 - 7e-06 25.9 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CRG88678.1 - 0.0021 18.7 0.0 0.0084 16.7 0.0 2.0 2 0 0 2 2 2 1 SnoaL-like domain DLH PF01738.18 CRG88678.1 - 0.071 12.6 0.1 0.17 11.4 0.1 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family Herpes_pp85 PF04637.12 CRG88678.1 - 0.15 10.5 0.1 0.24 9.8 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) AA_permease_2 PF13520.6 CRG88679.1 - 4.1e-89 299.3 42.7 4.1e-89 299.3 42.7 1.5 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 CRG88679.1 - 2.2e-13 49.6 42.5 3.6e-13 48.9 42.5 1.3 1 1 0 1 1 1 1 Amino acid permease SieB PF14163.6 CRG88679.1 - 1.2 8.6 5.6 11 5.5 0.0 2.9 3 0 0 3 3 3 0 Super-infection exclusion protein B Pentapeptide_4 PF13599.6 CRG88680.1 - 3.5e-05 23.9 1.0 0.019 15.1 0.0 3.1 1 1 3 4 4 4 4 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 CRG88680.1 - 0.00016 21.7 0.5 0.59 10.3 0.0 3.6 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) CfAFP PF05264.11 CRG88680.1 - 0.00057 19.9 1.3 0.00057 19.9 1.3 2.4 1 1 1 2 2 2 1 Choristoneura fumiferana antifreeze protein (CfAFP) DUF5473 PF17567.2 CRG88680.1 - 0.15 12.3 2.6 0.35 11.2 1.8 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5473) Pentapeptide PF00805.22 CRG88680.1 - 0.53 10.0 2.3 5.9 6.6 0.3 3.0 3 1 1 4 4 4 0 Pentapeptide repeats (8 copies) Zn_clus PF00172.18 CRG88681.1 - 1.1e-07 31.8 6.3 2.6e-07 30.7 6.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Erf4 PF10256.9 CRG88681.1 - 0.06 13.4 0.1 8.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family GDC-P PF02347.16 CRG88682.1 - 4e-176 586.1 0.0 3.5e-166 553.3 0.0 2.5 2 1 0 2 2 2 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 CRG88682.1 - 1.5e-06 27.7 0.1 3.9e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CRG88682.1 - 3.1e-05 23.1 0.1 0.0009 18.3 0.0 2.4 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG88682.1 - 0.095 12.0 0.5 0.25 10.6 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Amidohydro_1 PF01979.20 CRG88683.1 - 5.5e-67 226.5 0.0 7.6e-67 226.0 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Peptidase_S28 PF05577.12 CRG88683.1 - 3.6e-47 161.1 2.9 3e-39 135.0 0.2 2.3 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Amidohydro_3 PF07969.11 CRG88683.1 - 1.2e-07 31.6 0.3 3.3e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family tRNA_int_end_N2 PF12928.7 CRG88683.1 - 0.1 12.8 0.0 0.28 11.4 0.0 1.8 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term MFS_1 PF07690.16 CRG88684.1 - 2e-31 109.2 49.1 7.6e-30 104.0 41.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88684.1 - 2.1e-06 26.9 34.5 0.0064 15.4 6.8 3.6 2 2 2 4 4 4 3 Sugar (and other) transporter Fungal_trans PF04082.18 CRG88685.1 - 6.1e-10 38.6 0.4 8.6e-10 38.1 0.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Cep3 PF16846.5 CRG88685.1 - 0.00038 19.1 0.2 0.0013 17.3 0.1 1.8 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit B Cupin_2 PF07883.11 CRG88686.1 - 2.5e-09 36.7 0.0 1.5e-08 34.2 0.0 2.1 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 CRG88686.1 - 0.00092 18.9 0.0 0.0019 17.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_6 PF12852.7 CRG88686.1 - 0.018 14.7 0.0 0.025 14.3 0.0 1.2 1 0 0 1 1 1 0 Cupin Pyridoxal_deC PF00282.19 CRG88687.1 - 1.3e-101 340.1 0.0 1.6e-101 339.8 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 CRG88687.1 - 1.4e-06 27.8 0.3 2.6e-06 26.9 0.3 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase adh_short PF00106.25 CRG88688.1 - 1.9e-28 99.3 0.2 2.4e-27 95.7 0.2 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88688.1 - 2.1e-21 76.6 0.2 1.8e-20 73.5 0.2 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_hydro_43 PF04616.14 CRG88688.1 - 4.7e-06 26.1 0.1 8.8e-06 25.2 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 NAD_binding_10 PF13460.6 CRG88688.1 - 8.9e-06 25.7 0.1 0.00015 21.7 0.1 2.4 2 0 0 2 2 2 1 NAD(P)H-binding EGF_2 PF07974.13 CRG88688.1 - 0.00016 21.9 9.6 0.00045 20.5 9.6 1.8 1 0 0 1 1 1 1 EGF-like domain Epimerase PF01370.21 CRG88688.1 - 0.0002 20.9 0.0 0.00095 18.7 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG88688.1 - 0.033 13.7 0.1 0.053 13.1 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family RmlD_sub_bind PF04321.17 CRG88688.1 - 0.11 11.5 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain EGF PF00008.27 CRG88688.1 - 0.19 12.1 5.9 0.46 10.8 5.9 1.7 1 0 0 1 1 1 0 EGF-like domain hEGF PF12661.7 CRG88688.1 - 0.28 11.9 4.9 0.72 10.6 4.9 1.8 1 0 0 1 1 1 0 Human growth factor-like EGF Glyco_hydro_65N PF03636.15 CRG88689.1 - 3.9e-33 115.0 0.0 7.2e-33 114.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 CRG88689.1 - 4.9e-23 81.6 3.6 1.1e-17 64.0 0.5 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65C PF03633.15 CRG88689.1 - 0.00014 21.7 0.2 0.0056 16.6 0.1 2.5 1 1 1 2 2 2 1 Glycosyl hydrolase family 65, C-terminal domain F5_F8_type_C PF00754.25 CRG88689.1 - 0.00033 20.8 0.6 0.0027 17.8 0.1 2.9 2 1 0 2 2 2 1 F5/8 type C domain DUF5440 PF17509.2 CRG88689.1 - 0.16 11.5 0.1 10 5.8 0.0 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5440) SMC_Nse1 PF07574.13 CRG88690.1 - 7e-71 238.1 0.3 9e-71 237.8 0.3 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 CRG88690.1 - 3.7e-14 52.8 6.6 6.6e-14 51.9 6.6 1.4 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 CRG88690.1 - 0.0035 17.6 6.6 0.0056 17.0 6.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 CRG88690.1 - 0.041 13.9 1.8 0.074 13.1 1.8 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 CRG88690.1 - 0.068 12.8 1.6 0.56 9.9 0.1 2.7 3 0 0 3 3 3 0 P-11 zinc finger Mrr_N PF14338.6 CRG88690.1 - 0.13 12.4 0.0 0.46 10.7 0.0 1.8 1 0 0 1 1 1 0 Mrr N-terminal domain zf-C3HC4_2 PF13923.6 CRG88690.1 - 0.15 11.9 5.8 0.26 11.1 5.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.22 CRG88690.1 - 0.36 10.7 5.7 0.08 12.8 1.6 1.9 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 CRG88690.1 - 1.7 8.5 4.8 3.5 7.6 4.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DAO PF01266.24 CRG88691.1 - 4.1e-43 148.3 0.4 5.5e-43 147.9 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Fungal_trans_2 PF11951.8 CRG88691.1 - 2.1e-07 30.1 0.4 3e-07 29.6 0.4 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyr_redox_2 PF07992.14 CRG88691.1 - 0.016 14.5 0.0 0.28 10.4 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG88691.1 - 0.022 15.0 0.4 0.059 13.6 0.4 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 CRG88691.1 - 0.025 14.6 0.1 0.063 13.3 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 CRG88691.1 - 0.14 12.7 0.1 0.34 11.5 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF2606 PF10794.9 CRG88691.1 - 0.16 11.7 0.2 0.32 10.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) adh_short PF00106.25 CRG88692.1 - 3.8e-46 157.0 0.2 4.5e-46 156.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88692.1 - 1.7e-28 99.8 0.1 1.9e-28 99.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88692.1 - 3.2e-13 50.0 0.2 4.4e-13 49.5 0.2 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG88692.1 - 0.016 14.3 0.0 0.052 12.7 0.0 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1776 PF08643.10 CRG88692.1 - 0.059 12.7 0.0 0.077 12.3 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) CBFD_NFYB_HMF PF00808.23 CRG88694.1 - 9.9e-18 64.2 0.4 9.9e-18 64.2 0.4 1.8 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CRG88694.1 - 1.8e-06 28.3 0.2 5.7e-06 26.7 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 CRG88694.1 - 0.0075 16.3 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated DUF5333 PF17267.2 CRG88694.1 - 0.042 14.0 0.5 0.052 13.7 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5333) Hexokinase_1 PF00349.21 CRG88695.1 - 3.4e-49 167.5 0.0 7.2e-49 166.4 0.0 1.6 2 0 0 2 2 2 1 Hexokinase Hexokinase_2 PF03727.16 CRG88695.1 - 5.2e-42 143.9 0.0 8.3e-42 143.3 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Actin PF00022.19 CRG88695.1 - 3.6e-22 78.6 0.0 3.5e-20 72.0 0.0 2.9 3 0 0 3 3 3 2 Actin Kin17_mid PF10357.9 CRG88696.1 - 4.6e-50 168.8 4.2 4.6e-50 168.8 4.2 2.2 3 0 0 3 3 3 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_2 PF12756.7 CRG88696.1 - 0.007 16.7 0.2 0.007 16.7 0.2 2.2 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 CRG88696.1 - 1.2 9.7 4.9 0.93 10.0 2.8 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Fasciclin PF02469.22 CRG88697.1 - 1.8e-43 147.8 2.1 4.1e-21 75.5 0.1 2.2 2 0 0 2 2 2 2 Fasciclin domain Fungal_trans_2 PF11951.8 CRG88698.1 - 0.0015 17.4 0.8 0.014 14.2 0.8 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Ank_2 PF12796.7 CRG88699.1 - 4.8e-134 437.3 0.1 1.1e-17 64.4 0.0 8.3 1 1 10 11 11 11 11 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG88699.1 - 5.4e-71 234.1 0.0 3.2e-10 40.3 0.0 9.4 5 2 3 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 CRG88699.1 - 8.9e-71 231.5 0.0 9.2e-06 25.9 0.0 15.1 15 0 0 15 15 15 14 Ankyrin repeat Ank_3 PF13606.6 CRG88699.1 - 1.5e-67 215.5 0.0 0.00045 20.4 0.0 15.2 15 0 0 15 15 15 13 Ankyrin repeat Ank_5 PF13857.6 CRG88699.1 - 1.1e-53 178.6 1.4 5.5e-07 29.8 0.0 13.3 3 3 11 14 14 14 14 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 CRG88699.1 - 0.00013 21.3 0.1 0.0004 19.7 0.1 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily NB-ARC PF00931.22 CRG88699.1 - 0.036 13.2 0.0 1.1 8.4 0.0 2.2 1 1 1 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 CRG88699.1 - 0.064 13.6 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CRG88699.1 - 0.1 12.9 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain VWA_3_C PF18571.1 CRG88699.1 - 1.3 9.0 13.5 33 4.4 0.0 7.6 8 0 0 8 8 8 0 von Willebrand factor type A C-terminal domain p450 PF00067.22 CRG88700.1 - 9.6e-54 182.8 0.0 1.3e-53 182.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF1192 PF06698.11 CRG88700.1 - 0.45 10.6 3.2 24 5.1 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Peptidase_M19 PF01244.21 CRG88701.1 - 1.5e-104 349.6 0.0 1.8e-104 349.3 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) MFS_1 PF07690.16 CRG88702.1 - 6.3e-31 107.6 22.2 6.3e-31 107.6 22.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 CRG88703.1 - 1.4e-27 96.5 32.6 4.2e-14 52.2 9.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG88703.1 - 8.4e-06 24.9 12.9 0.00054 18.9 1.8 2.1 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 CRG88703.1 - 0.00025 20.1 3.0 0.00025 20.1 3.0 3.2 2 1 1 3 3 3 1 Sugar (and other) transporter DUF1624 PF07786.12 CRG88703.1 - 0.0063 16.1 0.0 0.0063 16.1 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1624) OATP PF03137.20 CRG88703.1 - 0.082 11.2 9.0 0.35 9.1 0.8 2.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Trypan_PARP PF05887.11 CRG88703.1 - 0.24 11.4 2.3 0.46 10.5 2.3 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) zf-RING_2 PF13639.6 CRG88704.1 - 9.8e-10 38.6 7.5 2e-09 37.6 7.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 CRG88704.1 - 3.3e-05 24.1 4.6 0.00013 22.2 4.6 2.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain PHD PF00628.29 CRG88704.1 - 5.4e-05 23.0 5.1 0.00017 21.4 5.1 1.9 1 0 0 1 1 1 1 PHD-finger zf-RING_11 PF17123.5 CRG88704.1 - 6.1e-05 22.7 1.3 0.00014 21.6 1.3 1.7 1 0 0 1 1 1 1 RING-like zinc finger FANCL_C PF11793.8 CRG88704.1 - 0.00048 20.3 4.7 0.0012 19.0 4.7 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 CRG88704.1 - 0.003 17.6 3.5 0.0088 16.1 3.5 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_1 PF14446.6 CRG88704.1 - 0.005 16.7 1.1 0.005 16.7 1.1 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 1 zf-C3HC4 PF00097.25 CRG88704.1 - 0.0051 16.7 2.3 0.015 15.2 2.3 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG88704.1 - 0.0073 16.2 5.4 0.0073 16.2 5.4 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CRG88704.1 - 0.018 15.1 4.1 0.042 13.9 4.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CRG88704.1 - 0.046 13.6 7.6 0.21 11.4 7.6 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Folate_carrier PF01770.18 CRG88704.1 - 0.065 12.0 0.8 0.098 11.4 0.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier C1_1 PF00130.22 CRG88704.1 - 0.11 12.4 3.3 0.13 12.2 1.7 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) BPS PF08947.10 CRG88704.1 - 0.18 11.7 2.0 0.37 10.7 0.1 2.5 2 0 0 2 2 2 0 BPS (Between PH and SH2) RR_TM4-6 PF06459.12 CRG88704.1 - 0.45 10.3 8.7 0.22 11.3 1.7 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RINGv PF12906.7 CRG88704.1 - 0.46 10.7 8.3 1.2 9.4 8.3 1.7 1 0 0 1 1 1 0 RING-variant domain Zf_RING PF16744.5 CRG88704.1 - 0.56 10.3 6.7 0.18 11.9 2.4 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger Zn_ribbon_17 PF17120.5 CRG88704.1 - 0.62 9.7 5.5 1.8 8.2 5.4 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 CRG88704.1 - 1.2 9.3 4.1 6.4 7.0 4.3 2.2 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-HC5HC2H PF13771.6 CRG88704.1 - 1.9 8.8 7.4 0.24 11.7 1.9 2.3 2 0 0 2 2 2 0 PHD-like zinc-binding domain DUF2207 PF09972.9 CRG88705.1 - 0.059 12.1 0.2 0.059 12.1 0.2 1.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF4232 PF14016.6 CRG88705.1 - 4.8 7.3 10.3 0.17 12.0 2.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4232) Snf7 PF03357.21 CRG88706.1 - 0.00077 19.1 10.9 0.00077 19.1 10.9 1.4 1 1 0 1 1 1 1 Snf7 DUF4157 PF13699.6 CRG88706.1 - 0.023 14.9 1.5 0.023 14.9 1.5 2.8 3 2 2 5 5 5 0 Domain of unknown function (DUF4157) Ist1 PF03398.14 CRG88706.1 - 0.075 13.0 5.4 0.12 12.3 5.4 1.4 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway bZIP_2 PF07716.15 CRG88707.1 - 1.1e-10 41.4 15.8 1.1e-10 41.4 15.8 2.5 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 CRG88707.1 - 2.4e-07 30.7 18.4 4.9e-07 29.8 18.4 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 CRG88707.1 - 0.00049 20.6 15.5 0.00095 19.6 15.5 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor APG6_N PF17675.1 CRG88707.1 - 0.0018 18.8 9.5 0.0034 17.9 9.5 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region Mcm10 PF09332.11 CRG88707.1 - 0.0041 16.6 4.8 0.007 15.8 4.8 1.3 1 0 0 1 1 1 1 Mcm10 replication factor Lsm_interact PF05391.11 CRG88707.1 - 0.37 10.4 2.3 0.43 10.1 0.4 2.2 2 0 0 2 2 2 0 Lsm interaction motif DUF3450 PF11932.8 CRG88707.1 - 0.47 9.7 8.3 0.71 9.1 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SOBP PF15279.6 CRG88707.1 - 0.97 10.0 11.4 1.2 9.7 11.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Bystin PF05291.11 CRG88708.1 - 6.9e-129 429.3 0.0 8.7e-129 428.9 0.0 1.1 1 0 0 1 1 1 1 Bystin SPRY PF00622.28 CRG88709.1 - 0.073 13.2 0.1 9.5 6.4 0.0 2.8 3 0 0 3 3 3 0 SPRY domain Amidase PF01425.21 CRG88710.1 - 3.4e-113 379.0 0.4 4.2e-113 378.7 0.4 1.0 1 0 0 1 1 1 1 Amidase ADH_zinc_N PF00107.26 CRG88711.1 - 2.7e-14 53.2 0.0 5.2e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88711.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Cupin_3 PF05899.12 CRG88711.1 - 0.042 13.5 0.3 0.11 12.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Metallophos PF00149.28 CRG88712.1 - 4.9e-12 46.8 1.6 4.9e-12 46.8 1.6 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase 5_nucleotid_C PF02872.18 CRG88712.1 - 0.044 14.0 0.0 0.098 12.9 0.0 1.5 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain Transket_pyr PF02779.24 CRG88713.1 - 4e-47 160.2 0.0 9.1e-47 159.0 0.0 1.6 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CRG88713.1 - 2.2e-35 121.3 0.0 1.5e-34 118.5 0.0 2.3 2 0 0 2 2 2 1 Transketolase, C-terminal domain TPP_enzyme_N PF02776.18 CRG88714.1 - 9e-37 126.3 0.1 1.9e-36 125.3 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG88714.1 - 1.6e-18 67.0 0.0 4.9e-18 65.4 0.0 1.9 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG88714.1 - 2.3e-09 37.1 0.0 5.9e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain zf-C2H2 PF00096.26 CRG88714.1 - 0.015 15.7 1.2 0.039 14.4 1.2 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-met PF12874.7 CRG88714.1 - 0.056 13.8 0.3 0.056 13.8 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CRG88714.1 - 0.089 13.1 1.8 0.16 12.3 1.8 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 CRG88714.1 - 0.29 11.5 1.6 0.85 10.0 0.3 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) MFS_1 PF07690.16 CRG88716.1 - 3.8e-35 121.5 27.3 3.8e-35 121.5 27.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88716.1 - 4e-12 45.7 6.2 4.7e-12 45.5 0.5 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter CCM2_C PF16545.5 CRG88716.1 - 0.15 12.6 0.0 0.27 11.8 0.0 1.4 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology DUF3328 PF11807.8 CRG88717.1 - 7.9e-38 130.4 6.2 9.5e-38 130.2 6.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Sdh_cyt PF01127.22 CRG88717.1 - 0.00096 19.2 0.6 0.007 16.4 0.1 2.1 2 0 0 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit GFO_IDH_MocA_C PF02894.17 CRG88717.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain DUF1691 PF07950.11 CRG88718.1 - 4.8e-39 133.4 6.5 9.6e-31 106.7 4.9 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) TRM PF02005.16 CRG88719.1 - 1.2e-111 373.5 0.0 1.4e-99 333.8 0.0 2.1 1 1 1 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Erg28 PF03694.13 CRG88719.1 - 3.1e-23 82.3 6.0 1.7e-22 79.9 5.6 2.2 2 0 0 2 2 2 1 Erg28 like protein Met_10 PF02475.16 CRG88719.1 - 5.6e-06 26.2 0.0 1.1e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein DUF2067 PF09840.9 CRG88719.1 - 0.00031 20.4 0.0 0.00073 19.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2067) UPF0547 PF10571.9 CRG88719.1 - 0.12 12.5 0.2 0.3 11.2 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 RPN2_C PF18004.1 CRG88719.1 - 2.7 7.9 9.9 12 5.8 0.0 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAS_I_H PF18314.1 CRG88720.1 - 1.3e-75 253.6 0.0 1.3e-75 253.6 0.0 2.1 2 0 0 2 2 2 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 CRG88720.1 - 1.3e-75 253.2 0.0 2.4e-75 252.3 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 CRG88720.1 - 3.8e-24 85.7 0.0 8.2e-24 84.5 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 CRG88720.1 - 1.6e-19 70.1 0.0 4.2e-19 68.7 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 CRG88720.1 - 9.8e-11 41.7 0.0 2.6e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 CRG88720.1 - 5.3e-06 26.0 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG88720.1 - 0.0095 15.9 0.0 0.034 14.0 0.0 1.9 1 0 0 1 1 1 1 KR domain DUF1729 PF08354.10 CRG88721.1 - 3.8e-162 539.2 0.0 5.8e-162 538.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 CRG88721.1 - 4.3e-90 302.4 0.0 4.1e-88 295.9 0.0 3.0 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 CRG88721.1 - 1.4e-52 177.4 0.1 4.7e-52 175.7 0.0 2.0 2 0 0 2 2 2 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 CRG88721.1 - 7.5e-40 137.2 0.1 1.8e-39 135.9 0.0 1.7 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis FAS_N PF17828.1 CRG88721.1 - 1e-38 132.2 0.1 3.7e-38 130.5 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydratas PF01575.19 CRG88721.1 - 1.2e-38 131.5 0.1 3.1e-38 130.1 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CRG88721.1 - 1.1e-21 77.4 0.0 2.7e-21 76.1 0.0 1.7 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase TFIIF_alpha PF05793.12 CRG88722.1 - 3.9e-08 32.4 4.2 3.9e-08 32.4 4.2 3.6 1 1 2 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GREB1 PF15782.5 CRG88722.1 - 3.4 4.7 10.9 5.3 4.0 10.9 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF383 PF04063.14 CRG88723.1 - 1.7e-69 233.3 0.2 5.1e-69 231.8 0.0 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 CRG88723.1 - 6e-22 77.3 3.7 3e-21 75.0 3.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF384) Inositol_P PF00459.25 CRG88724.1 - 1.2e-67 228.3 0.0 1.4e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family His_Phos_2 PF00328.22 CRG88725.1 - 3e-111 372.5 0.5 4.5e-111 371.9 0.5 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF676 PF05057.14 CRG88725.1 - 4.6e-38 130.9 0.0 1.7e-31 109.5 0.0 3.2 2 1 0 2 2 2 2 Putative serine esterase (DUF676) PPIP5K2_N PF18086.1 CRG88725.1 - 8.9e-38 128.3 0.0 2.1e-37 127.2 0.0 1.6 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 CRG88725.1 - 9.6e-06 25.3 0.0 1.9e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain DUF915 PF06028.11 CRG88725.1 - 0.0039 16.6 0.0 0.0082 15.5 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Lipase_3 PF01764.25 CRG88725.1 - 0.092 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) Utp21 PF04192.12 CRG88726.1 - 5.5e-72 242.0 0.9 8.3e-72 241.4 0.9 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 CRG88726.1 - 3.3e-21 75.2 22.5 3.4e-05 24.5 0.5 10.5 11 0 0 11 11 11 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88726.1 - 7.7e-14 51.8 1.7 0.0035 17.6 0.1 7.0 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 CRG88726.1 - 0.00023 21.4 0.1 0.00072 19.8 0.0 1.9 2 0 0 2 2 2 1 Dip2/Utp12 Family PALB2_WD40 PF16756.5 CRG88726.1 - 0.0093 14.9 1.5 6.2 5.6 0.0 3.9 4 1 0 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 CRG88726.1 - 0.12 10.9 0.0 0.4 9.2 0.0 1.8 2 0 0 2 2 2 0 Cytochrome D1 heme domain XPG_I_2 PF12813.7 CRG88727.1 - 2.8e-71 239.9 0.0 3.9e-71 239.4 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.18 CRG88727.1 - 0.0002 21.6 0.0 0.00043 20.6 0.0 1.5 1 0 0 1 1 1 1 XPG I-region Fcf1 PF04900.12 CRG88728.1 - 1.4e-37 128.1 1.4 1.5e-37 128.0 0.5 1.5 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 CRG88728.1 - 1.7e-12 47.7 0.7 4.4e-12 46.3 0.1 1.8 2 0 0 2 2 2 1 PIN like domain tRNA-synt_1b PF00579.25 CRG88729.1 - 2.9e-47 161.4 0.0 3.8e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Ribosomal_S10 PF00338.22 CRG88729.1 - 3.4e-27 94.5 0.0 1.4e-26 92.6 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein S10p/S20e Asp PF00026.23 CRG88730.1 - 1.8e-72 244.4 9.5 2.4e-72 244.0 9.5 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG88730.1 - 2e-09 37.9 12.7 1.4e-08 35.2 7.5 3.6 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG88730.1 - 1.2e-05 25.9 2.4 0.19 12.4 0.0 4.2 3 1 1 4 4 4 2 Aspartyl protease TAXi_C PF14541.6 CRG88730.1 - 0.036 13.8 0.0 0.095 12.5 0.0 1.7 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal Methyltransf_31 PF13847.6 CRG88731.1 - 2.6e-06 27.3 0.0 2.2e-05 24.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CRG88731.1 - 4.1e-05 23.2 0.1 0.0056 16.3 0.1 2.5 1 1 1 2 2 2 1 Methyltransferase small domain PrmC_N PF17827.1 CRG88731.1 - 0.0063 17.1 0.1 0.023 15.3 0.0 2.1 2 1 0 2 2 2 1 PrmC N-terminal domain Methyltransf_10 PF05971.12 CRG88731.1 - 0.0066 15.8 0.0 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 RNA methyltransferase PrmA PF06325.13 CRG88731.1 - 0.021 14.2 0.2 0.047 13.1 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 CRG88731.1 - 0.027 15.2 0.0 0.073 13.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 CRG88731.1 - 0.05 14.3 0.8 0.21 12.4 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain N6_Mtase PF02384.16 CRG88731.1 - 0.075 12.3 0.0 0.28 10.4 0.0 1.8 1 1 0 1 1 1 0 N-6 DNA Methylase Ubie_methyltran PF01209.18 CRG88731.1 - 0.093 12.0 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Fungal_trans PF04082.18 CRG88732.1 - 5.3e-28 97.8 0.2 5.3e-28 97.8 0.2 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Abhydrolase_1 PF00561.20 CRG88732.1 - 1.5e-14 54.3 0.0 1.5e-10 41.2 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Zn_clus PF00172.18 CRG88732.1 - 2.8e-09 36.9 6.7 5.6e-09 36.0 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydrolase_4 PF12146.8 CRG88732.1 - 2.4e-05 23.7 0.1 0.00049 19.4 0.1 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG88732.1 - 9.6e-05 23.1 0.0 0.00021 21.9 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CRG88732.1 - 0.0061 16.4 0.0 0.064 13.1 0.0 2.5 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Ndr PF03096.14 CRG88732.1 - 0.025 13.3 0.0 0.048 12.3 0.0 1.4 1 0 0 1 1 1 0 Ndr family FAD_binding_3 PF01494.19 CRG88733.1 - 1.1e-23 84.0 0.2 1.9e-23 83.3 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG88733.1 - 2.6e-08 34.0 1.6 5.9e-08 32.8 1.6 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG88733.1 - 4.6e-08 33.0 9.1 0.0018 17.9 7.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG88733.1 - 2.6e-07 30.2 6.7 0.00034 19.9 3.1 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG88733.1 - 7.3e-07 28.8 4.8 0.014 14.7 3.2 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CRG88733.1 - 2.5e-06 26.7 6.4 0.0053 15.7 3.2 2.5 3 0 0 3 3 3 2 Tryptophan halogenase HI0933_like PF03486.14 CRG88733.1 - 2.5e-06 26.5 3.1 6.8e-06 25.0 3.1 1.6 1 1 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 CRG88733.1 - 2.7e-06 27.0 2.3 4e-06 26.4 2.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG88733.1 - 0.00015 22.3 3.4 0.00031 21.2 0.9 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG88733.1 - 0.0004 19.6 7.2 0.00073 18.7 7.2 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 CRG88733.1 - 0.0055 16.0 8.4 0.34 10.1 5.8 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CRG88733.1 - 0.0089 15.3 1.7 0.021 14.1 1.7 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CRG88733.1 - 0.0093 16.0 3.7 0.57 10.2 0.1 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG88733.1 - 0.0096 15.0 3.4 0.038 13.0 3.4 1.8 1 1 0 1 1 1 1 Lycopene cyclase protein Rossmann-like PF10727.9 CRG88733.1 - 0.027 14.3 2.5 0.096 12.5 2.5 2.0 1 1 0 1 1 1 0 Rossmann-like domain GIDA PF01134.22 CRG88733.1 - 0.034 13.2 6.4 0.062 12.4 6.4 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A Thi4 PF01946.17 CRG88733.1 - 0.071 12.3 0.2 0.12 11.6 0.2 1.3 1 0 0 1 1 1 0 Thi4 family 3HCDH_N PF02737.18 CRG88733.1 - 0.24 11.3 1.1 0.5 10.2 1.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FA_hydroxylase PF04116.13 CRG88734.1 - 1.5e-24 86.8 15.6 1.5e-24 86.8 15.6 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily WD40 PF00400.32 CRG88735.1 - 3.3e-61 201.8 13.9 1.9e-09 38.0 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88735.1 - 6.5e-20 71.2 0.1 0.00055 20.2 0.0 6.5 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Tup_N PF08581.10 CRG88735.1 - 5.5e-18 65.0 9.3 9.4e-18 64.3 9.3 1.4 1 0 0 1 1 1 1 Tup N-terminal WD40_like PF17005.5 CRG88735.1 - 2.6e-08 33.6 0.0 0.052 12.9 0.0 4.9 4 1 2 6 6 6 2 WD40-like domain Nup160 PF11715.8 CRG88735.1 - 5e-06 25.4 0.1 0.27 9.8 0.0 3.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CRG88735.1 - 1.4e-05 24.3 0.1 0.56 9.1 0.0 4.6 1 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CRG88735.1 - 4.8e-05 22.1 0.5 0.00041 19.0 0.2 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 CRG88735.1 - 0.00061 19.7 0.0 0.05 13.5 0.0 3.0 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 CRG88735.1 - 0.033 13.5 0.1 7.1 5.9 0.0 2.8 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal zf-C2H2 PF00096.26 CRG88736.1 - 4.4e-17 61.5 23.3 0.0017 18.7 0.7 5.0 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG88736.1 - 1.7e-10 40.8 6.7 2.3e-08 34.1 1.1 5.8 7 0 0 7 7 7 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG88736.1 - 0.00074 20.2 3.8 0.031 15.1 0.2 5.2 5 0 0 5 5 5 3 C2H2-type zinc finger zf-met PF12874.7 CRG88736.1 - 0.0043 17.4 8.7 0.0096 16.3 0.1 4.2 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 CRG88736.1 - 0.12 12.5 6.3 10 6.2 0.2 3.5 1 1 1 3 3 3 0 Aberrant zinc-finger Mito_carr PF00153.27 CRG88737.1 - 4e-66 219.0 7.4 8.1e-22 77.0 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Nit_Regul_Hom PF10126.9 CRG88737.1 - 0.11 12.5 0.3 7.3 6.7 0.0 2.7 3 0 0 3 3 3 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII RRM_1 PF00076.22 CRG88738.1 - 2.6e-33 113.7 0.0 7.3e-16 57.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG88738.1 - 0.0015 18.6 0.0 0.0089 16.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 CRG88738.1 - 0.011 15.3 0.0 0.54 9.9 0.0 2.3 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cas_Cas2CT1978 PF09707.10 CRG88738.1 - 0.051 13.6 0.0 4.6 7.4 0.0 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) OB_RNB PF08206.11 CRG88738.1 - 0.11 12.2 0.4 4.1 7.2 0.1 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain Limkain-b1 PF11608.8 CRG88738.1 - 0.19 11.8 0.1 2 8.6 0.0 2.1 2 0 0 2 2 2 0 Limkain b1 DUF2015 PF09435.10 CRG88739.1 - 6.2e-47 158.1 0.0 7.1e-47 157.9 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Ldh_1_C PF02866.18 CRG88740.1 - 6.2e-43 146.6 0.0 9.2e-43 146.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CRG88740.1 - 7.5e-41 139.5 0.0 2.3e-40 138.0 0.0 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ribosomal_L28e PF01778.17 CRG88740.1 - 4.8e-30 104.7 0.4 1.1e-29 103.5 0.4 1.7 1 0 0 1 1 1 1 Ribosomal L28e protein family 3Beta_HSD PF01073.19 CRG88740.1 - 0.013 14.5 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Med3 PF11593.8 CRG88740.1 - 2.4 7.2 6.6 4.2 6.5 6.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal TRAPP PF04051.16 CRG88741.1 - 6.2e-47 159.0 0.0 7.3e-47 158.8 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PINIT PF14324.6 CRG88742.1 - 4.6e-42 143.8 0.9 8.6e-42 142.9 0.9 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 CRG88742.1 - 4.1e-22 77.7 8.2 6.8e-22 77.0 8.2 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CRG88742.1 - 1.6e-06 27.8 3.5 3.3e-06 26.8 3.5 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit SAP PF02037.27 CRG88742.1 - 1.3e-05 24.8 0.0 0.0001 21.9 0.0 2.3 2 0 0 2 2 2 1 SAP domain zf-Sec23_Sec24 PF04810.15 CRG88742.1 - 0.016 15.3 4.1 0.069 13.2 2.1 2.6 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger Prok-RING_4 PF14447.6 CRG88742.1 - 0.072 13.0 4.7 0.15 12.0 4.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-met PF12874.7 CRG88742.1 - 0.76 10.3 7.3 0.79 10.2 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF2423 PF10338.9 CRG88743.1 - 2.2e-17 63.0 3.9 4.5e-17 62.0 3.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Phosphodiest PF01663.22 CRG88743.1 - 4.7e-14 52.8 1.3 1.9e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CRG88743.1 - 2e-08 34.0 0.2 7.3e-08 32.1 0.2 1.8 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 CRG88743.1 - 0.022 13.4 0.0 0.032 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Caskin-tail PF16632.5 CRG88744.1 - 0.5 10.8 3.3 0.49 10.9 1.0 2.0 2 0 0 2 2 2 0 C-terminal region of Caskin RRM_2 PF04059.12 CRG88745.1 - 9.1e-38 128.4 0.3 1.5e-37 127.7 0.3 1.3 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 CRG88745.1 - 1.3e-08 34.5 0.2 0.0023 17.7 0.0 3.3 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sec15 PF04091.12 CRG88746.1 - 5.2e-109 364.5 0.6 5.2e-109 364.5 0.6 1.9 2 1 0 2 2 2 1 Exocyst complex subunit Sec15-like COG5 PF10392.9 CRG88746.1 - 0.00017 21.8 8.1 0.0036 17.5 5.5 3.2 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Sec8_exocyst PF04048.14 CRG88746.1 - 0.00049 20.0 2.7 0.00049 20.0 2.7 3.1 3 0 0 3 3 3 1 Sec8 exocyst complex component specific domain COG2 PF06148.11 CRG88746.1 - 0.0073 16.4 6.6 0.0082 16.2 4.0 2.5 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Rbsn PF11464.8 CRG88746.1 - 0.026 14.3 0.3 0.094 12.5 0.3 2.1 1 0 0 1 1 1 0 Rabenosyn Rab binding domain KELK PF15796.5 CRG88746.1 - 0.055 13.9 0.7 0.055 13.9 0.7 2.4 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Mre11_DNA_bind PF04152.14 CRG88746.1 - 0.13 12.6 1.8 0.73 10.1 0.0 3.1 3 0 0 3 3 3 0 Mre11 DNA-binding presumed domain Vps54_N PF10475.9 CRG88746.1 - 0.19 11.0 9.0 0.079 12.2 5.7 1.9 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex TSC22 PF01166.18 CRG88746.1 - 0.33 11.3 4.6 0.99 9.8 0.4 3.7 4 0 0 4 4 3 0 TSC-22/dip/bun family Sec5 PF15469.6 CRG88746.1 - 0.37 10.6 10.1 0.44 10.3 2.0 3.3 4 0 0 4 4 4 0 Exocyst complex component Sec5 DUF445 PF04286.12 CRG88746.1 - 0.5 10.1 13.6 0.43 10.3 4.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF445) DUF3510 PF12022.8 CRG88746.1 - 3.2 8.1 6.1 16 5.9 0.0 4.0 4 2 1 5 5 5 0 Domain of unknown function (DUF3510) MitMem_reg PF13012.6 CRG88746.1 - 9.7 6.7 10.2 1.9 8.9 0.2 4.1 4 1 1 5 5 5 0 Maintenance of mitochondrial structure and function CBFD_NFYB_HMF PF00808.23 CRG88747.1 - 7.7e-19 67.8 0.6 1.2e-18 67.2 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CRG88747.1 - 8.2e-16 58.6 0.3 1.5e-15 57.7 0.3 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-X PF09415.10 CRG88747.1 - 0.048 14.0 0.0 0.094 13.1 0.0 1.4 1 1 0 1 1 1 0 CENP-S associating Centromere protein X Fcf2 PF08698.11 CRG88748.1 - 7.3e-36 122.5 0.9 1.9e-35 121.1 0.9 1.7 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing PNP_UDP_1 PF01048.20 CRG88749.1 - 2.8e-55 187.1 0.1 3.8e-55 186.7 0.1 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily MIF4G_like PF09088.11 CRG88750.1 - 1.5e-90 302.1 0.1 2.3e-90 301.5 0.1 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 CRG88750.1 - 1.7e-72 244.1 0.0 2.6e-72 243.5 0.0 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 CRG88750.1 - 7.8e-05 22.4 0.0 0.00025 20.8 0.0 1.8 2 0 0 2 2 2 1 MIF4G domain Pkinase PF00069.25 CRG88751.1 - 1.2e-65 221.6 0.0 1.4e-65 221.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88751.1 - 1.5e-25 90.0 0.0 2e-25 89.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG88751.1 - 1.3e-06 27.9 0.0 1.3e-05 24.7 0.0 2.1 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 CRG88751.1 - 0.0025 17.8 1.0 0.013 15.4 0.1 2.3 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG88751.1 - 0.12 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Porin_3 PF01459.22 CRG88752.1 - 1.3e-82 277.3 0.0 1.6e-82 277.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic porin Zds_C PF08632.10 CRG88752.1 - 0.0087 15.8 0.0 0.022 14.5 0.0 1.6 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term 6PF2K PF01591.18 CRG88753.1 - 3e-61 206.6 0.0 4.1e-61 206.1 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CRG88753.1 - 3.7e-22 79.0 0.5 3.1e-21 76.0 0.5 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 CRG88753.1 - 0.051 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 APS_kinase PF01583.20 CRG88753.1 - 0.062 13.2 0.0 0.67 9.8 0.0 2.2 1 1 0 1 1 1 0 Adenylylsulphate kinase Urm1 PF09138.11 CRG88754.1 - 9e-33 112.5 0.0 1e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 CRG88754.1 - 0.0033 18.0 0.0 0.0043 17.7 0.0 1.2 1 0 0 1 1 1 1 ThiS family WD40 PF00400.32 CRG88755.1 - 8.2e-35 118.2 20.2 2.4e-05 25.0 0.1 12.0 13 0 0 13 13 13 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88755.1 - 9.1e-10 38.7 2.3 0.19 12.0 0.0 7.5 5 3 2 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG88755.1 - 0.0079 15.2 0.0 29 3.5 0.0 4.5 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 CRG88755.1 - 0.037 12.8 0.7 6.1 5.5 0.0 3.6 3 2 2 5 5 5 0 Nup133 N terminal like ABC_tran PF00005.27 CRG88756.1 - 3.2e-15 56.8 0.1 6.1e-14 52.7 0.1 2.2 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 CRG88756.1 - 5.7e-11 42.8 2.8 0.00013 21.9 0.6 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG88756.1 - 0.00054 19.5 0.0 0.47 9.9 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG88756.1 - 0.00087 19.0 0.1 0.0017 18.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF3584 PF12128.8 CRG88756.1 - 0.0011 16.6 0.1 0.0015 16.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_15 PF13175.6 CRG88756.1 - 0.0018 18.0 0.0 0.0028 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 CRG88756.1 - 0.0058 17.2 0.1 0.0095 16.5 0.1 1.3 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 CRG88756.1 - 0.0062 16.3 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 CRG88756.1 - 0.02 14.8 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_28 PF13521.6 CRG88756.1 - 0.033 14.4 0.4 0.063 13.5 0.4 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CRG88756.1 - 0.05 13.2 0.1 0.095 12.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 CRG88756.1 - 0.071 12.6 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_16 PF13191.6 CRG88756.1 - 0.078 13.4 0.6 0.13 12.6 0.5 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_13 PF13166.6 CRG88756.1 - 0.092 11.4 0.0 0.12 10.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CRG88756.1 - 0.096 13.0 0.6 0.27 11.5 0.6 2.0 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 CRG88756.1 - 0.17 11.5 0.1 0.25 11.0 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CRG88756.1 - 0.22 11.2 0.1 0.53 10.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CRG88756.1 - 0.23 11.9 0.4 1.5 9.3 0.4 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IPPT PF01715.17 CRG88757.1 - 1.7e-63 214.5 0.5 1.7e-63 214.5 0.5 1.6 2 0 0 2 2 2 1 IPP transferase AAA_33 PF13671.6 CRG88757.1 - 2e-05 24.8 0.3 0.0038 17.4 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CRG88757.1 - 0.00013 22.5 1.3 0.067 13.7 1.3 2.9 1 1 0 1 1 1 1 AAA domain IPT PF01745.16 CRG88757.1 - 0.00042 19.8 0.0 0.00082 18.8 0.0 1.5 1 0 0 1 1 1 1 Isopentenyl transferase AAA_16 PF13191.6 CRG88757.1 - 0.0054 17.1 0.1 0.029 14.8 0.0 2.1 2 2 0 2 2 2 1 AAA ATPase domain zf-C2H2_jaz PF12171.8 CRG88757.1 - 0.014 15.7 0.0 0.033 14.5 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding AAA_22 PF13401.6 CRG88757.1 - 0.02 15.2 0.0 0.074 13.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 CRG88757.1 - 0.027 14.4 0.1 0.66 9.9 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 CRG88757.1 - 0.034 14.4 0.3 0.38 11.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain zf-met PF12874.7 CRG88757.1 - 0.039 14.3 0.0 0.082 13.3 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Cnl2_NKP2 PF09447.10 CRG88757.1 - 0.046 13.9 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 Cnl2/NKP2 family protein Cytidylate_kin PF02224.18 CRG88757.1 - 0.047 13.4 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase RNA_helicase PF00910.22 CRG88757.1 - 0.054 13.9 0.0 0.42 11.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase SKI PF01202.22 CRG88757.1 - 0.09 12.9 0.2 11 6.1 0.0 2.8 2 0 0 2 2 2 0 Shikimate kinase DUF87 PF01935.17 CRG88757.1 - 0.13 12.3 0.3 0.79 9.8 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain RAI1 PF08652.11 CRG88758.1 - 1.8e-27 95.3 0.0 4.1e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease DUF410 PF04190.13 CRG88759.1 - 7.3e-87 291.4 0.0 8.8e-87 291.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) FSA_C PF10479.9 CRG88760.1 - 1.2 7.1 5.5 1.8 6.6 5.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ald_Xan_dh_C2 PF02738.18 CRG88761.1 - 1.7e-199 663.9 0.0 3.2e-199 663.0 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 CRG88761.1 - 1.5e-38 132.3 0.1 2.7e-38 131.4 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 CRG88761.1 - 1.5e-34 118.2 0.0 3.9e-33 113.7 0.0 2.6 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 CRG88761.1 - 6.2e-27 94.1 0.0 1.2e-26 93.2 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 CRG88761.1 - 2.4e-26 91.6 0.0 5.3e-26 90.5 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 CRG88761.1 - 1.8e-07 31.0 1.0 2.9e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Rep_fac_C PF08542.11 CRG88762.1 - 3e-22 78.8 0.0 8e-22 77.5 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 CRG88762.1 - 4.8e-11 42.7 0.0 5.2e-08 32.8 0.0 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 CRG88762.1 - 1.5e-10 41.6 0.0 2.7e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 CRG88762.1 - 7.4e-07 29.3 0.0 2e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG88762.1 - 2.2e-05 24.9 0.0 0.00053 20.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 CRG88762.1 - 7.8e-05 22.5 0.0 0.00048 19.9 0.0 2.0 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 CRG88762.1 - 0.00011 22.1 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 CRG88762.1 - 0.00021 21.1 0.0 0.00036 20.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 CRG88762.1 - 0.00024 20.9 0.0 0.00051 19.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CRG88762.1 - 0.00047 20.5 0.0 0.3 11.3 0.0 2.6 1 1 1 2 2 2 1 AAA domain NCD1 PF04904.13 CRG88762.1 - 0.0081 16.1 0.3 0.044 13.8 0.0 2.4 3 0 0 3 3 3 1 NAB conserved region 1 (NCD1) MeaB PF03308.16 CRG88762.1 - 0.013 14.5 0.0 0.026 13.5 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Mg_chelatase PF01078.21 CRG88762.1 - 0.016 14.6 0.0 0.089 12.2 0.0 2.0 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI KTI12 PF08433.10 CRG88762.1 - 0.032 13.7 0.0 0.15 11.5 0.0 2.0 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Rad17 PF03215.15 CRG88762.1 - 0.033 14.1 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_assoc_2 PF16193.5 CRG88762.1 - 0.035 14.4 0.0 0.098 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain His_Phos_2 PF00328.22 CRG88762.1 - 0.062 12.6 0.0 0.17 11.2 0.0 1.6 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) AAA_11 PF13086.6 CRG88762.1 - 0.07 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CRG88762.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.6 CRG88762.1 - 0.14 12.5 0.1 0.66 10.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CRG88762.1 - 0.19 11.5 0.0 0.8 9.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AA_permease_2 PF13520.6 CRG88763.1 - 6.8e-64 216.3 42.6 9.2e-64 215.8 42.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG88763.1 - 2.3e-27 95.7 30.0 2.3e-27 95.7 30.0 2.0 2 0 0 2 2 2 1 Amino acid permease NAD_binding_1 PF00175.21 CRG88764.1 - 1.7e-09 38.3 0.0 1.6e-06 28.7 0.0 2.4 1 1 0 2 2 2 2 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CRG88764.1 - 1.5e-05 25.3 0.0 6.1e-05 23.3 0.0 2.1 2 1 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CRG88764.1 - 0.00019 21.6 0.0 0.0004 20.5 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Myb_DNA-binding PF00249.31 CRG88765.1 - 2e-32 111.1 5.5 1e-11 44.8 0.1 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG88765.1 - 5.4e-32 109.8 4.2 4.8e-14 52.3 0.1 3.6 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CRG88765.1 - 0.00011 22.0 0.0 0.29 11.0 0.0 3.2 2 1 1 3 3 3 2 Myb DNA-binding like SLIDE PF09111.10 CRG88765.1 - 0.0026 17.7 0.0 0.14 12.2 0.0 2.7 2 1 1 3 3 3 1 SLIDE MADF_DNA_bdg PF10545.9 CRG88765.1 - 0.028 14.7 2.9 3.4 8.0 0.1 3.0 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_2 PF08914.11 CRG88765.1 - 0.046 13.9 0.0 10 6.4 0.0 3.0 3 0 0 3 3 3 0 Rap1 Myb domain AGA2 PF17366.2 CRG88765.1 - 0.13 11.9 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 A-agglutinin-binding subunit Aga2 SANT_DAMP1_like PF16282.5 CRG88765.1 - 0.18 12.0 1.3 1.6 8.9 0.1 2.8 4 0 0 4 4 4 0 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.8 CRG88765.1 - 0.53 10.4 6.0 14 5.8 0.7 3.2 2 1 1 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain FH2 PF02181.23 CRG88767.1 - 3.5e-86 289.7 7.8 3.5e-86 289.7 7.8 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 CRG88767.1 - 3.6e-68 228.9 0.1 3.6e-68 228.9 0.1 2.1 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 CRG88767.1 - 1.6e-50 171.5 0.0 1.6e-50 171.5 0.0 3.0 2 1 1 3 3 3 1 Diaphanous FH3 Domain Nrap_D6 PF17407.2 CRG88767.1 - 0.15 12.2 0.1 2.5 8.3 0.1 2.9 3 0 0 3 3 3 0 Nrap protein domain 6 GTA_holin_3TM PF11351.8 CRG88767.1 - 0.42 11.2 2.0 3.1 8.3 2.0 2.6 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release TrmE_N PF10396.9 CRG88768.1 - 2.7e-37 127.6 0.0 1.4e-36 125.3 0.0 2.2 3 0 0 3 3 2 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 CRG88768.1 - 1.4e-32 113.5 1.2 2.5e-24 86.6 0.5 2.3 2 0 0 2 2 2 2 MnmE helical domain MMR_HSR1 PF01926.23 CRG88768.1 - 4.6e-18 65.4 0.0 8.4e-18 64.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG88768.1 - 4.7e-05 23.0 0.0 0.00012 21.6 0.0 1.7 1 1 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 CRG88768.1 - 5e-05 22.9 0.1 0.0024 17.4 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 CRG88768.1 - 6.5e-05 23.1 0.1 0.00033 20.7 0.0 2.0 1 1 0 2 2 2 1 Dynamin family RsgA_GTPase PF03193.16 CRG88768.1 - 0.0035 17.3 0.1 1.3 8.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 CRG88768.1 - 0.0038 17.0 0.1 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain Glyco_hydro_3_C PF01915.22 CRG88768.1 - 0.0072 16.3 0.0 0.019 14.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Arf PF00025.21 CRG88768.1 - 0.017 14.6 0.1 7.3 6.0 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Roc PF08477.13 CRG88768.1 - 0.028 14.6 0.0 0.26 11.5 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 CRG88768.1 - 0.16 12.5 0.1 0.51 10.8 0.1 1.8 1 0 0 1 1 1 0 ABC transporter 2-Hacid_dh_C PF02826.19 CRG88769.1 - 1.1e-51 174.7 0.0 2.1e-51 173.8 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG88769.1 - 5.7e-15 55.2 0.0 1.2e-14 54.1 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG88769.1 - 0.00071 19.8 0.0 0.0016 18.6 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 CRG88769.1 - 0.03 13.6 0.2 0.63 9.3 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain IER PF05760.12 CRG88769.1 - 0.096 13.0 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 Immediate early response protein (IER) Suc_Fer-like PF06999.12 CRG88770.1 - 4.6e-56 189.8 0.0 8.4e-56 188.9 0.0 1.4 1 0 0 1 1 1 1 Sucrase/ferredoxin-like tRNA-synt_1 PF00133.22 CRG88770.1 - 1.8e-53 181.8 0.0 1.8e-35 122.3 0.0 5.9 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 CRG88770.1 - 6.3e-40 136.7 0.0 9.9e-40 136.0 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 CRG88770.1 - 5.6e-30 104.4 0.1 2.3e-22 79.3 0.0 4.9 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 CRG88770.1 - 9e-12 45.2 0.0 1.6e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1d PF00750.19 CRG88770.1 - 0.038 13.0 0.0 0.077 11.9 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (R) tRNA-synt_1e PF01406.19 CRG88770.1 - 0.11 11.8 0.0 4 6.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain DUF1772 PF08592.11 CRG88771.1 - 0.08 13.3 0.3 0.08 13.3 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Fungal_trans_2 PF11951.8 CRG88772.1 - 3.4e-09 36.0 0.1 7.1e-09 34.9 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain CPBP PF02517.16 CRG88773.1 - 5.8e-16 58.6 7.1 5.8e-16 58.6 7.1 2.5 3 1 0 3 3 3 1 CPBP intramembrane metalloprotease MBOAT PF03062.19 CRG88775.1 - 3.8e-56 190.9 4.2 3.8e-56 190.9 4.2 1.9 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family PAP2 PF01569.21 CRG88775.1 - 1.7 8.4 9.2 0.5 10.1 3.4 2.7 3 0 0 3 3 3 0 PAP2 superfamily Sec1 PF00995.23 CRG88776.1 - 1.1e-134 450.9 0.0 1.3e-134 450.6 0.0 1.0 1 0 0 1 1 1 1 Sec1 family adh_short PF00106.25 CRG88777.1 - 2.3e-33 115.3 0.0 3.2e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88777.1 - 5.8e-22 78.4 0.0 7.7e-22 78.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88777.1 - 2.7e-12 47.0 0.0 4e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG88777.1 - 1.7e-05 24.4 0.1 3.5e-05 23.4 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CRG88777.1 - 0.00055 19.2 0.0 0.0007 18.8 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CRG88777.1 - 0.035 13.2 0.0 0.052 12.7 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain TPP_enzyme_M PF00205.22 CRG88777.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain GDP_Man_Dehyd PF16363.5 CRG88777.1 - 0.17 11.3 0.1 0.3 10.5 0.1 1.4 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CRG88777.1 - 0.18 11.4 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family NAD_binding_8 PF13450.6 CRG88778.1 - 1.7e-12 47.3 0.5 1.7e-12 47.3 0.5 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG88778.1 - 4.1e-06 26.6 0.1 8.2e-06 25.6 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG88778.1 - 3.1e-05 23.3 0.0 4.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG88778.1 - 0.00085 18.5 1.7 0.0013 17.9 1.7 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CRG88778.1 - 0.00086 18.1 0.5 0.0016 17.2 0.5 1.4 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_9 PF13454.6 CRG88778.1 - 0.0012 18.9 0.1 0.0035 17.4 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 CRG88778.1 - 0.0014 17.9 0.1 0.0027 17.0 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 CRG88778.1 - 0.016 15.8 0.1 0.049 14.2 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG88778.1 - 0.019 14.1 1.1 0.027 13.5 1.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 CRG88778.1 - 0.024 13.7 0.3 0.034 13.2 0.3 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 CRG88778.1 - 0.075 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG88778.1 - 0.3 10.3 0.3 0.46 9.7 0.3 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Tyr-DNA_phospho PF06087.12 CRG88779.1 - 4.4e-99 332.3 0.0 5.5e-99 331.9 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase UIM PF02809.20 CRG88779.1 - 6.8e-05 22.5 2.8 6.8e-05 22.5 2.8 2.4 3 0 0 3 3 3 1 Ubiquitin interaction motif PLDc_2 PF13091.6 CRG88779.1 - 0.0017 18.2 0.0 0.018 15.0 0.0 2.3 2 0 0 2 2 2 1 PLD-like domain ABC2_membrane PF01061.24 CRG88780.1 - 3.2e-78 262.0 60.4 4e-42 144.0 31.2 3.7 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 CRG88780.1 - 8.1e-38 130.0 0.9 8.6e-20 71.7 0.0 3.0 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CRG88780.1 - 8.1e-26 89.8 12.8 2.6e-25 88.1 0.0 3.5 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CRG88780.1 - 9.7e-15 55.0 0.2 2.6e-14 53.6 0.2 1.8 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 CRG88780.1 - 6.3e-06 26.2 0.1 0.00071 19.5 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 CRG88780.1 - 3.8e-05 24.2 0.0 0.0075 16.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 CRG88780.1 - 6.9e-05 22.1 13.5 6.9e-05 22.1 13.5 3.7 4 0 0 4 4 4 1 ABC-2 family transporter protein cobW PF02492.19 CRG88780.1 - 8.2e-05 22.3 0.0 0.01 15.4 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 CRG88780.1 - 9.2e-05 22.4 0.0 0.23 11.2 0.0 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CRG88780.1 - 0.00014 21.5 1.4 0.37 10.3 0.3 4.0 5 0 0 5 5 4 1 AAA domain AAA_28 PF13521.6 CRG88780.1 - 0.00018 21.8 0.1 0.0076 16.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CRG88780.1 - 0.00028 21.0 0.0 0.059 13.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG88780.1 - 0.00037 20.8 0.0 0.098 12.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 CRG88780.1 - 0.00045 20.7 0.0 0.046 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 CRG88780.1 - 0.00046 20.3 0.4 0.32 11.1 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 CRG88780.1 - 0.0021 17.8 0.6 0.13 12.0 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_17 PF13207.6 CRG88780.1 - 0.012 16.0 0.1 1.2 9.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 CRG88780.1 - 0.015 14.6 0.8 1.2 8.4 0.2 2.7 3 0 0 3 3 3 0 Septin NACHT PF05729.12 CRG88780.1 - 0.022 14.7 0.2 1 9.2 0.2 2.4 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 CRG88780.1 - 0.035 13.8 0.2 1.2 8.8 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CRG88780.1 - 0.074 12.8 1.9 2.7 7.7 1.0 2.5 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CRG88780.1 - 0.18 11.8 0.3 3.3 7.7 0.4 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.18 CRG88780.1 - 0.22 10.9 0.4 7.3 5.9 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Viral_helicase1 PF01443.18 CRG88780.1 - 0.37 10.5 1.7 14 5.3 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Sugar_tr PF00083.24 CRG88781.1 - 1.4e-90 304.4 24.9 1.6e-90 304.2 24.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88781.1 - 5.9e-28 97.8 54.1 1.5e-22 80.1 30.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily PMP1_2 PF08114.11 CRG88781.1 - 0.07 12.9 0.2 0.07 12.9 0.2 2.9 3 0 0 3 3 3 0 ATPase proteolipid family DUF3995 PF13160.6 CRG88781.1 - 4.3 7.7 15.1 0.14 12.5 0.4 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3995) ADH_N PF08240.12 CRG88782.1 - 9e-24 83.5 1.6 1.6e-23 82.6 1.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG88782.1 - 2.1e-20 73.0 0.5 3.2e-20 72.4 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG88782.1 - 2.2e-05 24.1 0.1 3.1e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CRG88782.1 - 0.00011 23.3 0.1 0.00018 22.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase LDcluster4 PF18306.1 CRG88782.1 - 0.018 14.7 0.8 0.066 12.8 0.8 2.0 1 1 0 1 1 1 0 SLOG cluster4 family Methyltransf_32 PF13679.6 CRG88782.1 - 0.083 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Arginase PF00491.21 CRG88783.1 - 1.7e-15 57.3 0.0 2e-15 57.1 0.0 1.0 1 0 0 1 1 1 1 Arginase family Fungal_trans PF04082.18 CRG88784.1 - 2e-30 105.7 0.0 3.5e-30 105.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88784.1 - 4.5e-07 29.9 12.0 7.6e-07 29.1 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FlxA PF14282.6 CRG88784.1 - 0.13 12.2 0.2 0.26 11.3 0.2 1.5 1 0 0 1 1 1 0 FlxA-like protein adh_short PF00106.25 CRG88785.1 - 2.1e-33 115.4 0.1 2.9e-33 115.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88785.1 - 2.4e-24 86.2 0.1 4.9e-23 81.9 0.1 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88785.1 - 9.4e-13 48.5 0.1 1.4e-12 47.9 0.1 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG88785.1 - 0.011 14.9 0.0 0.012 14.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein QRPTase_C PF01729.19 CRG88785.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain MFS_1 PF07690.16 CRG88786.1 - 2.7e-38 131.8 39.6 3.6e-33 114.9 19.2 2.7 1 1 2 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88786.1 - 1.4e-13 50.5 6.6 1.4e-13 50.5 6.6 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG88786.1 - 5.7e-05 21.7 3.9 5.7e-05 21.7 3.9 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 CRG88786.1 - 0.0013 17.7 1.5 0.0013 17.7 1.5 2.0 2 1 1 3 3 3 1 MFS_1 like family MFS_3 PF05977.13 CRG88786.1 - 0.0033 15.9 10.6 0.0054 15.2 10.6 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector DUF5362 PF17319.2 CRG88786.1 - 0.044 13.6 0.0 0.2 11.5 0.0 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5362) Lactamase_B PF00753.27 CRG88787.1 - 2.2e-09 37.6 0.3 1.1e-08 35.3 0.3 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG88787.1 - 3.1e-05 23.6 0.1 6e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Zn_clus PF00172.18 CRG88789.1 - 7.4e-08 32.4 9.5 1.2e-07 31.7 9.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG88789.1 - 7.7e-08 31.7 1.1 1.9e-07 30.4 1.1 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain ADH_zinc_N PF00107.26 CRG88790.1 - 2.5e-14 53.4 0.1 5.6e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG88790.1 - 0.0001 22.2 0.0 0.00024 20.9 0.0 1.8 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CRG88790.1 - 0.00056 19.3 0.8 0.00091 18.6 0.8 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NmrA PF05368.13 CRG88790.1 - 0.02 14.4 0.5 0.034 13.7 0.5 1.3 1 0 0 1 1 1 0 NmrA-like family DapB_N PF01113.20 CRG88790.1 - 0.021 15.0 0.1 0.039 14.1 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 CRG88790.1 - 0.029 14.2 0.3 0.05 13.5 0.3 1.3 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 CRG88790.1 - 0.079 12.4 0.6 0.12 11.8 0.6 1.2 1 0 0 1 1 1 0 short chain dehydrogenase adh_short PF00106.25 CRG88791.1 - 2.4e-35 121.8 0.1 4.9e-35 120.8 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88791.1 - 1.1e-27 97.1 0.1 1.9e-27 96.4 0.1 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88791.1 - 6.2e-09 36.0 0.3 8.8e-09 35.5 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG88791.1 - 0.0085 15.6 0.1 0.018 14.5 0.1 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG88791.1 - 0.058 13.3 0.3 0.095 12.6 0.3 1.4 1 1 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG88791.1 - 0.15 11.5 0.1 0.62 9.4 0.1 1.8 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase Gti1_Pac2 PF09729.9 CRG88792.1 - 1.2e-62 211.3 0.0 2.2e-62 210.4 0.0 1.5 1 0 0 1 1 1 1 Gti1/Pac2 family CDP-OH_P_transf PF01066.21 CRG88792.1 - 8.9e-14 52.0 0.8 8.9e-14 52.0 0.8 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase GIDA PF01134.22 CRG88793.1 - 2.6e-155 517.4 0.0 3.2e-155 517.0 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 CRG88793.1 - 1e-66 225.1 0.0 1.5e-66 224.6 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 CRG88793.1 - 3.8e-06 26.5 0.6 5.8e-06 25.9 0.6 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG88793.1 - 2.3e-05 23.8 0.4 5.5e-05 22.5 0.4 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG88793.1 - 0.0035 16.5 2.5 0.0035 16.5 2.5 1.8 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 CRG88793.1 - 0.0051 16.1 0.1 0.013 14.9 0.1 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CRG88793.1 - 0.11 11.7 0.0 0.25 10.6 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG88793.1 - 0.13 11.8 2.2 7.5 6.0 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase K_oxygenase PF13434.6 CRG88793.1 - 0.13 11.3 0.1 0.24 10.5 0.1 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CRG88793.1 - 0.24 10.1 4.0 0.37 9.5 0.9 2.3 3 0 0 3 3 3 0 HI0933-like protein ARD PF03079.14 CRG88794.1 - 2.8e-44 151.1 0.3 3.3e-44 150.8 0.3 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 CRG88794.1 - 1.1e-08 34.7 0.0 1.7e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 CRG88794.1 - 0.00013 21.9 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain MMM1 PF10296.9 CRG88795.1 - 8.8e-133 442.4 0.0 1.1e-132 442.1 0.0 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 SARAF PF06682.12 CRG88796.1 - 3.2e-95 319.6 3.3 3.3e-94 316.2 3.3 1.9 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SelK_SelG PF10961.8 CRG88796.1 - 2.5 8.8 11.2 0.19 12.4 0.5 3.2 3 0 0 3 3 3 0 Selenoprotein SelK_SelG Myb_DNA-bind_7 PF15963.5 CRG88797.1 - 3.9e-29 100.4 1.2 9.6e-29 99.1 0.1 2.3 1 1 1 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 CRG88797.1 - 2.4e-07 30.8 0.0 6.2e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PNRC PF15365.6 CRG88797.1 - 2.4 8.1 8.5 5.2 7.0 1.3 3.3 2 0 0 2 2 2 0 Proline-rich nuclear receptor coactivator motif BRE1 PF08647.11 CRG88798.1 - 2.1e-27 95.0 13.4 2.1e-27 95.0 13.4 6.7 5 1 2 7 7 7 1 BRE1 E3 ubiquitin ligase Phage_tail_T PF06223.12 CRG88798.1 - 0.016 15.7 6.4 6.3 7.4 0.3 3.8 3 0 0 3 3 3 0 Minor tail protein T HisK_N PF09385.10 CRG88798.1 - 0.042 13.8 1.8 0.066 13.2 0.1 2.3 2 0 0 2 2 2 0 Histidine kinase N terminal Prefoldin_2 PF01920.20 CRG88798.1 - 0.067 13.1 0.4 0.067 13.1 0.4 10.3 8 1 1 10 10 10 0 Prefoldin subunit UreF PF01730.16 CRG88799.1 - 1.6e-23 83.7 0.1 2.4e-23 83.2 0.1 1.2 1 0 0 1 1 1 1 UreF Sugarporin_N PF11471.8 CRG88799.1 - 0.031 14.2 0.3 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension TcpS PF17456.2 CRG88799.1 - 0.22 11.6 0.1 0.49 10.4 0.1 1.5 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S ABC1 PF03109.16 CRG88800.1 - 1.4e-33 115.6 0.0 7.5e-33 113.2 0.0 2.2 2 0 0 2 2 2 1 ABC1 family AMPK1_CBM PF16561.5 CRG88801.1 - 1.7e-25 89.0 0.2 5.3e-24 84.3 0.2 2.3 1 1 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 CRG88801.1 - 2.7e-17 62.8 0.2 8.6e-17 61.2 0.2 1.9 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain Peptidase_M22 PF00814.25 CRG88803.1 - 3.5e-85 286.0 0.0 4.2e-85 285.7 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 CRG88803.1 - 0.05 13.3 0.0 1.6 8.3 0.0 2.1 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus SET PF00856.28 CRG88804.1 - 4.8e-21 75.9 0.0 1.8e-20 74.0 0.0 1.8 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 CRG88804.1 - 3.4e-14 53.6 4.0 9.7e-14 52.2 1.3 2.7 3 0 0 3 3 3 1 Rubisco LSMT substrate-binding EPL1 PF10513.9 CRG88805.1 - 2.6e-19 70.1 0.3 2.6e-19 70.1 0.3 2.8 2 1 0 2 2 2 1 Enhancer of polycomb-like DUF3993 PF13158.6 CRG88805.1 - 0.11 12.7 1.1 0.26 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) DUF2218 PF09981.9 CRG88805.1 - 2.2 8.8 9.7 11 6.5 1.2 4.2 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2218) EF-hand_1 PF00036.32 CRG88806.1 - 1.5e-27 93.1 13.0 2.7e-08 32.8 1.3 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 CRG88806.1 - 2.7e-22 79.0 7.6 1.2e-13 51.3 1.8 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 CRG88806.1 - 3.4e-21 73.3 5.8 0.00012 21.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 CRG88806.1 - 7.6e-19 66.3 10.6 4.9e-07 29.0 0.7 4.4 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 CRG88806.1 - 1.5e-13 50.3 12.1 7.7e-05 22.5 0.6 4.7 3 1 2 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 CRG88806.1 - 2.9e-07 30.8 0.0 0.0011 19.3 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 CRG88806.1 - 9.4e-05 22.3 9.3 0.17 11.9 0.4 4.0 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CRG88806.1 - 0.11 12.8 0.2 1.5 9.2 0.1 2.5 2 1 1 3 3 3 0 EF-hand domain TarH PF02203.15 CRG88807.1 - 0.014 15.3 0.3 0.03 14.3 0.3 1.5 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF1266 PF06889.11 CRG88807.1 - 0.043 13.9 0.0 0.082 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) RPN6_C_helix PF18503.1 CRG88807.1 - 0.95 9.3 2.4 0.62 9.9 0.3 1.8 2 0 0 2 2 2 0 26S proteasome subunit RPN6 C-terminal helix domain Ribosomal_S9 PF00380.19 CRG88808.1 - 4.2e-39 133.8 0.1 3e-38 131.0 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S9/S16 EF1G PF00647.19 CRG88809.1 - 7e-45 151.5 0.0 1.4e-44 150.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 CRG88809.1 - 2.6e-15 56.5 0.0 6.4e-15 55.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG88809.1 - 3.4e-14 52.8 1.9 4.5e-14 52.4 0.0 2.3 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG88809.1 - 2.5e-09 37.0 0.7 1.8e-08 34.3 0.1 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG88809.1 - 4.1e-07 30.3 0.0 9e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG88809.1 - 1.9e-06 28.0 0.0 7.1e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG88809.1 - 7.4e-05 23.0 0.6 0.00039 20.6 0.0 2.6 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain NIF PF03031.18 CRG88810.1 - 5.7e-23 81.4 0.4 2.9e-21 75.8 0.4 2.4 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase DUF705 PF05152.12 CRG88810.1 - 0.028 13.9 0.0 0.042 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF705) S-antigen PF05756.11 CRG88810.1 - 0.15 12.4 1.1 0.57 10.6 1.1 1.9 1 0 0 1 1 1 0 S-antigen protein RRP36 PF06102.12 CRG88811.1 - 6e-48 162.9 27.5 6e-48 162.9 27.5 2.8 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 RNA_pol_L_2 PF13656.6 CRG88813.1 - 1.7e-33 114.2 0.0 2.3e-33 113.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CRG88813.1 - 1.5e-14 53.1 0.0 2.3e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain IKKbetaNEMObind PF12179.8 CRG88814.1 - 0.0027 17.7 0.0 0.062 13.3 0.0 2.1 2 0 0 2 2 2 1 I-kappa-kinase-beta NEMO binding domain Complex1_LYR PF05347.15 CRG88814.1 - 0.0032 17.5 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 CRG88814.1 - 0.016 15.9 1.7 0.025 15.3 1.7 1.3 1 1 0 1 1 1 0 Complex1_LYR-like HHH_9 PF17674.1 CRG88815.1 - 0.35 11.8 3.2 11 7.0 0.0 2.5 2 0 0 2 2 2 0 HHH domain Abhydrolase_1 PF00561.20 CRG88816.1 - 3.5e-10 40.0 0.1 2e-09 37.5 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG88816.1 - 9.7e-07 28.3 0.0 9.2e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 EAV_GS PF01309.18 CRG88816.1 - 0.15 11.6 0.2 0.59 9.7 0.1 1.8 1 1 1 2 2 2 0 Equine arteritis virus small envelope glycoprotein F-box_4 PF15966.5 CRG88817.1 - 0.0039 17.1 0.8 0.01 15.7 0.0 2.1 3 0 0 3 3 3 1 F-box F-box-like PF12937.7 CRG88817.1 - 0.044 13.7 0.9 0.13 12.1 0.1 2.3 2 0 0 2 2 2 0 F-box-like TLD PF07534.16 CRG88817.1 - 0.15 12.3 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 TLD Cohesin_load PF10345.9 CRG88819.1 - 3.7e-166 554.1 1.6 4.9e-166 553.7 1.6 1.1 1 0 0 1 1 1 1 Cohesin loading factor Telomere_reg-2 PF10193.9 CRG88819.1 - 0.046 14.2 4.3 7.8 7.0 0.1 4.1 4 1 1 5 5 5 0 Telomere length regulation protein TPR_4 PF07721.14 CRG88819.1 - 0.074 13.7 0.2 0.61 10.9 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC5 PF12862.7 CRG88819.1 - 0.078 13.0 0.4 0.4 10.8 0.4 2.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 Lactamase_B_4 PF13691.6 CRG88819.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease Histone PF00125.24 CRG88820.1 - 1.2e-40 138.9 0.5 1.2e-40 138.9 0.5 2.0 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 CRG88820.1 - 9.2e-05 22.5 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 CRG88820.1 - 0.0011 19.3 0.1 0.0017 18.7 0.1 1.3 1 0 0 1 1 1 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 CRG88820.1 - 0.035 14.4 0.5 0.068 13.5 0.5 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CRG88820.1 - 0.13 12.3 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit DER1 PF04511.15 CRG88821.1 - 5.3e-50 170.0 1.9 6.2e-50 169.8 1.9 1.0 1 0 0 1 1 1 1 Der1-like family Gly_transf_sug PF04488.15 CRG88822.1 - 6.2e-21 74.9 0.0 1.3e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TctB PF07331.11 CRG88822.1 - 0.061 13.6 0.4 0.061 13.6 0.4 1.8 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Nitroreductase PF00881.24 CRG88824.1 - 1.4e-12 48.0 0.0 2.1e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Nitroreductase family IGPD PF00475.18 CRG88825.1 - 1.5e-55 187.5 1.2 4.6e-55 185.9 1.1 1.7 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase Arena_RNA_pol PF06317.11 CRG88825.1 - 0.13 9.5 0.0 0.17 9.1 0.0 1.0 1 0 0 1 1 1 0 Arenavirus RNA polymerase LRR_6 PF13516.6 CRG88827.1 - 0.00034 20.4 0.1 33 4.9 0.0 6.4 6 1 0 6 6 6 2 Leucine Rich repeat Pet127 PF08634.10 CRG88828.1 - 5.4e-122 406.5 0.8 1.1e-121 405.5 0.8 1.5 1 0 0 1 1 1 1 Mitochondrial protein Pet127 DUF3275 PF11679.8 CRG88828.1 - 0.3 11.0 2.5 1 9.3 2.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) GARS_A PF01071.19 CRG88829.1 - 2.7e-83 278.5 0.0 4.2e-83 277.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 CRG88829.1 - 1.5e-34 118.7 0.1 6.5e-34 116.6 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 CRG88829.1 - 3.2e-30 105.3 0.0 8.4e-30 104.0 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 CRG88829.1 - 7.7e-28 96.6 0.4 2.3e-27 95.1 0.4 1.9 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 CRG88829.1 - 1.9e-14 54.1 4.5 3.9e-14 53.1 3.3 2.2 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 CRG88829.1 - 0.00014 21.5 0.0 0.00024 20.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 CRG88829.1 - 0.00078 19.5 0.0 0.0035 17.4 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CRG88829.1 - 0.0017 17.8 0.2 0.0056 16.2 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 CRG88829.1 - 0.0064 16.1 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 CRG88829.1 - 0.12 11.6 0.0 0.35 10.1 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Actin PF00022.19 CRG88830.1 - 2.1e-145 484.4 0.0 1.1e-144 482.1 0.0 2.0 1 1 0 1 1 1 1 Actin Fes1 PF08609.10 CRG88831.1 - 2.6e-29 102.0 1.1 2.6e-29 102.0 1.1 1.9 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT_EZ PF13513.6 CRG88831.1 - 1.9e-09 37.8 0.2 1.2e-08 35.2 0.0 2.4 2 0 0 2 2 2 1 HEAT-like repeat Arm PF00514.23 CRG88831.1 - 1.1e-07 31.7 0.1 0.011 15.7 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 CRG88831.1 - 1.3e-06 28.2 0.0 0.02 15.1 0.0 3.1 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 CRG88831.1 - 2.5e-06 27.8 0.3 7.2e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 HEAT repeats AIRC PF00731.20 CRG88831.1 - 0.0089 15.6 0.1 0.13 11.8 0.1 2.1 1 1 0 1 1 1 1 AIR carboxylase DUF3458_C PF17432.2 CRG88831.1 - 0.044 13.2 1.0 0.097 12.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3458_C) ARM repeats V-ATPase_H_C PF11698.8 CRG88831.1 - 0.081 13.0 0.1 2 8.5 0.0 2.1 1 1 1 2 2 2 0 V-ATPase subunit H V-ATPase_H_N PF03224.14 CRG88831.1 - 0.086 12.1 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 V-ATPase subunit H UPF0220 PF05255.11 CRG88832.1 - 1.8e-69 232.6 4.7 2e-69 232.4 4.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) G3P_antiterm PF04309.12 CRG88832.1 - 0.15 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator Sld7_C PF18596.1 CRG88833.1 - 1.3e-14 54.1 0.0 3.3e-14 52.8 0.0 1.7 1 0 0 1 1 1 1 Sld7 C-terminal domain Vps55 PF04133.14 CRG88834.1 - 1.1e-43 147.9 8.6 1.3e-43 147.7 8.6 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 Med6 PF04934.14 CRG88835.1 - 1.6e-36 125.1 0.0 3.3e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 MED6 mediator sub complex component Lysine_decarbox PF03641.14 CRG88835.1 - 4.2e-28 98.1 0.1 1.1e-27 96.7 0.1 1.7 1 1 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 CRG88835.1 - 0.015 14.9 0.3 0.015 14.9 0.3 1.9 2 0 0 2 2 2 0 SLOG cluster4 family Proteasome PF00227.26 CRG88836.1 - 3.5e-47 160.4 0.0 4.3e-47 160.1 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 CRG88836.1 - 3e-12 46.0 0.3 4.9e-12 45.3 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF2862 PF11061.8 CRG88836.1 - 0.072 12.9 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2862) RdRP PF05183.12 CRG88837.1 - 2.2e-175 584.7 0.0 2.8e-175 584.3 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase eIF_4EBP PF05456.11 CRG88837.1 - 0.04 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Latarcin PF10279.9 CRG88837.1 - 0.22 12.0 0.3 0.78 10.2 0.1 2.0 2 1 0 2 2 2 0 Latarcin precursor Cyclin PF08613.11 CRG88838.1 - 3.9e-06 27.3 0.7 1.1e-05 25.9 0.0 2.2 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 CRG88838.1 - 0.0021 17.8 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pyrid_oxidase_2 PF13883.6 CRG88839.1 - 2.9e-32 112.0 0.0 8.8e-32 110.4 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase GATA PF00320.27 CRG88840.1 - 3.1e-16 58.7 2.3 3.1e-16 58.7 2.3 1.8 2 0 0 2 2 2 1 GATA zinc finger DUF1752 PF08550.10 CRG88840.1 - 1.6e-12 47.0 2.6 3e-12 46.1 2.6 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) AreA_N PF07573.11 CRG88840.1 - 9.2e-05 23.0 0.0 9.2e-05 23.0 0.0 4.1 4 0 0 4 4 4 1 Nitrogen regulatory protein AreA N terminus HSP9_HSP12 PF04119.12 CRG88841.1 - 0.013 15.9 1.5 0.034 14.5 0.1 2.3 1 1 2 3 3 3 0 Heat shock protein 9/12 HlyIII PF03006.20 CRG88842.1 - 8e-49 166.4 14.9 1e-48 166.0 14.9 1.1 1 0 0 1 1 1 1 Haemolysin-III related Robl_LC7 PF03259.17 CRG88843.1 - 2.5e-08 33.6 3.3 0.012 15.3 0.4 3.3 3 0 0 3 3 3 3 Roadblock/LC7 domain Myc_N PF01056.18 CRG88843.1 - 0.044 13.7 3.0 0.066 13.1 3.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Ipi1_N PF12333.8 CRG88844.1 - 1.5e-27 96.1 0.0 1.5e-27 96.1 0.0 2.5 2 1 1 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.6 CRG88844.1 - 0.0082 16.5 0.6 0.022 15.1 0.5 1.8 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 CRG88844.1 - 0.021 15.0 2.4 7.2 7.2 0.1 3.5 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 CRG88844.1 - 0.045 14.3 3.4 0.12 13.0 0.6 2.8 1 1 2 3 3 3 0 HEAT-like repeat Zn_clus PF00172.18 CRG88845.1 - 2.3e-08 34.0 6.9 3.3e-08 33.5 6.9 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DLH PF01738.18 CRG88847.1 - 7.3e-13 48.6 0.0 9.4e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Lactamase_B PF00753.27 CRG88848.1 - 2e-16 60.6 6.2 2.6e-16 60.2 6.2 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG88848.1 - 0.0001 21.9 1.4 0.0004 20.0 2.0 1.7 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Aldedh PF00171.22 CRG88849.1 - 3e-150 500.7 0.0 3.9e-150 500.4 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sugar_tr PF00083.24 CRG88849.1 - 1.5e-35 123.0 25.6 1.4e-20 73.6 9.2 3.1 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG88849.1 - 1.4e-06 27.5 34.1 0.02 13.8 27.6 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1487 PF07368.11 CRG88849.1 - 0.0024 17.3 0.0 0.11 11.9 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) ADH_N PF08240.12 CRG88850.1 - 1.6e-27 95.5 1.1 7.3e-27 93.4 0.9 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG88850.1 - 4.5e-14 52.5 0.0 7.8e-14 51.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG88850.1 - 1.8e-05 25.8 0.1 5.8e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 CRG88850.1 - 0.00014 21.7 0.0 0.00014 21.7 0.0 2.1 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-associated Glu_dehyd_C PF16912.5 CRG88850.1 - 0.026 14.0 0.0 0.069 12.6 0.0 1.8 1 1 0 1 1 1 0 Glucose dehydrogenase C-terminus Epimerase PF01370.21 CRG88851.1 - 3.1e-07 30.1 0.0 5.6e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG88851.1 - 0.0067 15.6 0.0 0.73 8.9 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Fungal_trans PF04082.18 CRG88852.1 - 2.2e-05 23.7 0.1 3.8e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CoA_transf_3 PF02515.17 CRG88853.1 - 1e-118 396.7 0.0 1.3e-118 396.4 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III SAM_4 PF18017.1 CRG88853.1 - 0.072 13.1 0.0 0.31 11.1 0.0 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Acyl-CoA_dh_1 PF00441.24 CRG88854.1 - 2.5e-35 121.9 4.4 3.9e-35 121.3 4.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CRG88854.1 - 1.8e-24 86.6 0.7 3.4e-24 85.7 0.1 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CRG88854.1 - 1.5e-17 63.5 0.0 2.8e-17 62.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CRG88854.1 - 5.1e-16 59.2 0.9 5.1e-16 59.2 0.9 1.9 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Glucosaminidase PF01832.20 CRG88854.1 - 0.024 15.2 0.1 0.12 12.9 0.0 2.1 2 0 0 2 2 2 0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase zf-C2H2 PF00096.26 CRG88855.1 - 1.1e-10 41.3 11.4 7.1e-05 23.0 0.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG88855.1 - 5.1e-09 36.2 9.8 0.00028 21.5 1.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG88855.1 - 2.6e-06 27.6 15.5 3.1e-05 24.2 3.3 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CRG88855.1 - 0.001 19.3 3.3 0.028 14.7 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 CRG88855.1 - 0.0078 16.0 8.0 0.72 9.7 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2HE PF16278.5 CRG88855.1 - 0.047 14.1 9.9 0.87 10.1 1.7 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 CRG88855.1 - 0.059 13.1 2.9 1.2 9.0 0.3 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 CRG88855.1 - 0.25 11.4 2.1 0.32 11.1 0.3 2.1 2 0 0 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.6 CRG88855.1 - 2.9 8.0 14.9 0.85 9.7 0.6 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Pyridoxal_deC PF00282.19 CRG88856.1 - 3.4e-60 203.7 0.0 4.9e-60 203.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CRG88856.1 - 1.8e-05 23.9 0.0 2.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Fungal_trans_2 PF11951.8 CRG88857.1 - 2.5e-55 187.9 0.4 3.5e-55 187.4 0.4 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hormone_3 PF00159.18 CRG88858.1 - 0.078 13.1 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide Pkinase PF00069.25 CRG88859.1 - 3.5e-61 206.9 0.0 2e-60 204.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88859.1 - 8.1e-29 100.7 0.3 5.3e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase EutQ PF06249.12 CRG88859.1 - 5.9e-11 42.4 0.0 1.1e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 CRG88859.1 - 3.2e-08 33.1 0.0 7.1e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_2 PF07883.11 CRG88859.1 - 2.1e-05 24.1 0.0 6.8e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Cupin domain Pkinase_C PF00433.24 CRG88859.1 - 3.1e-05 24.6 0.6 0.00011 22.8 0.6 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 CRG88859.1 - 0.0018 17.6 0.1 0.0091 15.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 CRG88859.1 - 0.0031 17.5 2.1 0.23 11.3 0.1 3.2 3 1 1 4 4 4 2 Phosphotransferase enzyme family Pirin PF02678.16 CRG88859.1 - 0.016 15.2 0.0 0.12 12.4 0.0 2.4 3 0 0 3 3 3 0 Pirin Haspin_kinase PF12330.8 CRG88859.1 - 0.021 13.8 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 CRG88859.1 - 0.084 12.2 0.0 0.19 11.0 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cupin_1 PF00190.22 CRG88859.1 - 0.13 11.8 0.0 0.35 10.5 0.0 1.7 1 0 0 1 1 1 0 Cupin DUF1687 PF07955.11 CRG88860.1 - 1.6e-28 99.7 0.0 2.5e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) ArsC PF03960.15 CRG88860.1 - 0.078 13.0 0.0 0.3 11.1 0.0 1.9 2 0 0 2 2 2 0 ArsC family Glyco_hydro_79C PF16862.5 CRG88861.1 - 3.6e-16 59.9 0.3 1.1e-15 58.4 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain NPCBM_assoc PF10633.9 CRG88861.1 - 0.14 12.5 0.0 0.45 10.8 0.0 1.9 1 0 0 1 1 1 0 NPCBM-associated, NEW3 domain of alpha-galactosidase FAD_binding_8 PF08022.12 CRG88862.1 - 3.8e-20 72.0 0.0 8.1e-20 70.9 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CRG88862.1 - 6.7e-19 68.2 10.0 1.4e-18 67.2 10.0 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG88862.1 - 9.6e-18 64.8 0.0 1.6e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ctr PF04145.15 CRG88863.1 - 7.7e-32 111.0 0.1 9e-32 110.7 0.1 1.0 1 0 0 1 1 1 1 Ctr copper transporter family Flu_M1 PF00598.19 CRG88864.1 - 0.22 11.0 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 Influenza Matrix protein (M1) Aminotran_1_2 PF00155.21 CRG88865.1 - 1.4e-39 136.3 0.0 1.8e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II NpwBP PF12622.7 CRG88865.1 - 0.012 16.3 0.0 0.04 14.7 0.0 1.8 1 0 0 1 1 1 0 mRNA biogenesis factor Beta_elim_lyase PF01212.21 CRG88865.1 - 0.16 11.2 0.0 2.7 7.2 0.0 2.0 2 0 0 2 2 2 0 Beta-eliminating lyase AA_permease PF00324.21 CRG88866.1 - 1.9e-111 373.0 34.1 2.1e-111 372.9 34.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG88866.1 - 1.2e-28 100.1 36.0 1.5e-28 99.8 36.0 1.1 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.16 CRG88867.1 - 1e-37 129.9 35.0 1.3e-37 129.6 35.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88867.1 - 5.3e-10 38.7 14.3 1.3e-09 37.5 14.3 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88868.1 - 6.4e-31 107.6 43.8 1.7e-30 106.2 43.8 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88868.1 - 0.0042 16.0 28.5 0.013 14.4 11.1 2.8 3 0 0 3 3 3 2 Sugar (and other) transporter DUF5316 PF17247.2 CRG88868.1 - 0.14 12.2 0.1 0.14 12.2 0.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5316) DUF5337 PF17272.2 CRG88868.1 - 0.27 11.1 1.4 0.78 9.6 1.4 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5337) IDO PF01231.18 CRG88869.1 - 4e-26 91.8 0.1 4.7e-26 91.6 0.1 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Lyase_aromatic PF00221.19 CRG88870.1 - 3.7e-100 335.8 2.9 4.6e-100 335.5 2.9 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase NMO PF03060.15 CRG88873.1 - 1e-27 97.4 0.1 1.3e-27 97.1 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 CRG88873.1 - 3.2e-05 23.1 1.3 5.2e-05 22.4 1.3 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CRG88873.1 - 0.00034 19.8 0.0 0.00065 18.9 0.0 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG88873.1 - 0.00045 19.3 0.4 0.00074 18.6 0.4 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CRG88873.1 - 0.099 12.1 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein Abhydrolase_2 PF02230.16 CRG88874.1 - 5.7e-58 196.3 0.0 7e-58 196.0 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CRG88874.1 - 1e-05 25.1 0.1 0.00072 19.1 0.0 2.3 1 1 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CRG88874.1 - 4.2e-05 22.9 0.2 0.14 11.4 0.0 3.1 2 1 1 3 3 3 2 Serine aminopeptidase, S33 FSH1 PF03959.13 CRG88874.1 - 0.00015 21.5 0.0 0.00033 20.4 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 CRG88874.1 - 0.00032 20.6 0.0 0.0072 16.2 0.0 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 CRG88874.1 - 0.00056 19.5 0.0 0.00099 18.7 0.0 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 CRG88874.1 - 0.0024 18.5 0.0 0.012 16.2 0.0 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG88874.1 - 0.015 15.0 0.5 0.22 11.1 0.5 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 CRG88874.1 - 0.015 15.1 0.0 0.075 12.8 0.0 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF1581 PF07619.11 CRG88874.1 - 0.031 14.4 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1581) AXE1 PF05448.12 CRG88874.1 - 0.041 12.5 0.0 0.065 11.9 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF2920 PF11144.8 CRG88874.1 - 0.084 12.0 0.0 3.6 6.7 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2920) Esterase PF00756.20 CRG88874.1 - 0.16 11.6 0.1 0.34 10.5 0.0 1.4 1 1 0 1 1 1 0 Putative esterase Aspzincin_M35 PF14521.6 CRG88875.1 - 2.7e-05 24.7 2.9 0.00039 21.0 0.5 2.6 2 1 0 2 2 2 1 Lysine-specific metallo-endopeptidase Abhydrolase_1 PF00561.20 CRG88876.1 - 1.1e-29 103.8 0.0 1.6e-29 103.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG88876.1 - 5.2e-13 48.8 0.0 2.2e-12 46.7 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG88876.1 - 1.1e-08 35.9 0.0 1.7e-08 35.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CRG88876.1 - 0.00034 20.2 0.0 0.0029 17.1 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Ndr PF03096.14 CRG88876.1 - 0.12 11.0 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Ndr family SKG6 PF08693.10 CRG88877.1 - 6.8e-05 22.2 1.0 6.8e-05 22.2 1.0 2.7 3 0 0 3 3 3 1 Transmembrane alpha-helix domain Mid2 PF04478.12 CRG88877.1 - 0.015 15.2 3.0 0.07 13.0 2.7 2.3 2 1 0 2 2 2 0 Mid2 like cell wall stress sensor Granulin PF00396.18 CRG88877.1 - 0.093 13.1 0.8 0.093 13.1 0.8 2.2 2 0 0 2 2 2 0 Granulin Glyco_hydro_18 PF00704.28 CRG88879.1 - 2.9e-47 161.9 3.0 4.7e-47 161.2 3.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 LysM PF01476.20 CRG88879.1 - 6.6e-11 42.1 0.1 1e-05 25.5 0.1 2.8 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 CRG88879.1 - 3.5e-05 24.2 7.6 3.5e-05 24.2 7.6 3.6 3 1 0 3 3 3 1 Chitin recognition protein Glyco_hydro_46 PF01374.18 CRG88880.1 - 0.1 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 Ank_4 PF13637.6 CRG88881.1 - 1.4e-16 60.6 7.9 0.0029 18.1 0.0 8.6 7 3 2 9 9 9 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG88881.1 - 1e-13 51.7 0.1 0.00089 19.8 0.0 6.3 4 2 1 5 5 5 4 Ankyrin repeats (3 copies) Ank PF00023.30 CRG88881.1 - 5e-12 45.7 6.2 0.18 12.3 0.1 7.9 8 0 0 8 8 8 3 Ankyrin repeat Ank_5 PF13857.6 CRG88881.1 - 2.5e-11 43.6 7.0 0.58 10.6 0.1 7.6 7 1 0 7 7 7 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG88881.1 - 1.3e-09 37.5 4.0 8.7 7.3 0.0 8.7 8 1 0 8 8 8 3 Ankyrin repeat adh_short PF00106.25 CRG88882.1 - 2.5e-25 89.1 0.0 3e-19 69.2 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88882.1 - 2.3e-14 53.6 0.2 7e-09 35.6 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88882.1 - 9.7e-09 35.4 0.0 2e-08 34.3 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG88882.1 - 0.0017 17.5 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAC PF01849.18 CRG88883.1 - 1e-24 86.3 0.6 1.8e-24 85.5 0.6 1.4 1 0 0 1 1 1 1 NAC domain His_Phos_2 PF00328.22 CRG88884.1 - 2.5e-42 145.6 0.0 2.9e-42 145.4 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) FMN_dh PF01070.18 CRG88885.1 - 4.5e-120 400.8 0.0 5.1e-120 400.7 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 CRG88885.1 - 1.1e-05 25.0 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 CRG88885.1 - 1.2e-05 24.7 0.0 0.088 12.1 0.1 3.2 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG Glu_synthase PF01645.17 CRG88885.1 - 0.00019 20.7 0.1 0.00029 20.1 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG88885.1 - 0.00025 20.2 0.4 0.00044 19.3 0.4 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 CRG88885.1 - 0.0012 18.4 0.1 0.13 11.7 0.1 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein IGPS PF00218.21 CRG88885.1 - 0.064 12.4 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase Lipase_3 PF01764.25 CRG88886.1 - 2e-16 60.1 0.0 2.3e-14 53.5 0.0 2.7 2 1 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 CRG88886.1 - 0.006 17.2 0.2 0.015 15.9 0.2 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG88886.1 - 0.15 11.3 0.0 0.27 10.4 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 SMC_N PF02463.19 CRG88887.1 - 4.2e-22 78.7 0.0 1.3e-21 77.1 0.0 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG88887.1 - 4.9e-21 76.1 0.2 4.9e-21 76.1 0.2 4.7 2 2 2 4 4 3 1 AAA domain AAA_21 PF13304.6 CRG88887.1 - 0.0002 21.3 3.0 0.035 13.9 0.0 3.4 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Tropomyosin_1 PF12718.7 CRG88887.1 - 0.003 17.7 15.2 0.003 17.7 15.2 6.3 3 2 3 6 6 5 1 Tropomyosin like AAA_29 PF13555.6 CRG88887.1 - 0.0034 17.1 0.0 0.0081 15.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_27 PF13514.6 CRG88887.1 - 0.0075 15.9 8.0 0.11 12.1 0.0 4.0 3 0 0 3 3 3 1 AAA domain BCDHK_Adom3 PF10436.9 CRG88887.1 - 0.022 14.6 5.9 0.015 15.1 3.1 2.1 2 0 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Peptidase_M3_N PF08439.10 CRG88887.1 - 0.033 14.4 0.1 0.2 11.9 0.1 2.4 1 0 0 1 1 1 0 Oligopeptidase F Syntaxin-6_N PF09177.11 CRG88887.1 - 0.04 14.5 37.0 2 9.0 3.4 6.8 4 2 1 5 5 5 0 Syntaxin 6, N-terminal AAA PF00004.29 CRG88887.1 - 0.11 12.9 0.0 0.71 10.3 0.0 2.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CRG88887.1 - 0.13 11.8 3.8 0.27 10.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain GAS PF13851.6 CRG88887.1 - 0.36 10.1 61.7 0.31 10.4 12.8 4.9 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 CRG88887.1 - 1.2 9.3 0.0 1.2 9.3 0.0 5.6 3 2 1 5 5 5 0 Fibrinogen alpha/beta chain family DUF3287 PF11690.8 CRG88887.1 - 8.6 6.1 12.6 0.46 10.2 0.9 3.9 2 2 1 3 3 3 0 Protein of unknown function (DUF3287) AdoMet_MTase PF07757.13 CRG88888.1 - 5.4e-36 123.3 0.2 2.1e-35 121.4 0.2 1.9 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase PHD PF00628.29 CRG88889.1 - 2.7e-05 24.0 7.0 5.2e-05 23.1 7.0 1.5 1 0 0 1 1 1 1 PHD-finger Spt20 PF12090.8 CRG88889.1 - 0.00011 21.9 7.3 0.00011 21.9 7.3 2.2 2 0 0 2 2 2 1 Spt20 family DUF4763 PF15960.5 CRG88889.1 - 0.0014 18.0 1.6 0.0014 18.0 1.6 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4763) TERB2 PF15101.6 CRG88889.1 - 0.012 15.7 3.4 0.012 15.7 3.4 2.1 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Zf_RING PF16744.5 CRG88889.1 - 0.012 15.7 7.0 0.047 13.8 6.4 2.2 1 1 1 2 2 2 0 KIAA1045 RING finger DUF1192 PF06698.11 CRG88889.1 - 0.017 15.1 0.5 0.076 13.1 0.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) zf-C2HC_2 PF13913.6 CRG88889.1 - 0.057 13.3 0.6 0.1 12.5 0.6 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type PHD_2 PF13831.6 CRG88889.1 - 0.098 12.2 3.7 0.25 10.9 3.7 1.7 1 0 0 1 1 1 0 PHD-finger ZapB PF06005.12 CRG88889.1 - 0.26 11.8 0.0 0.26 11.8 0.0 3.5 3 1 0 3 3 3 0 Cell division protein ZapB TMEM61 PF15105.6 CRG88889.1 - 0.34 10.7 3.4 0.32 10.8 0.3 2.3 2 0 0 2 2 2 0 TMEM61 protein family DNApol_Exo PF18136.1 CRG88889.1 - 0.52 9.4 4.8 1 8.4 4.8 1.4 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain FAM60A PF15396.6 CRG88889.1 - 0.8 9.7 10.0 3.7 7.5 1.0 2.3 2 0 0 2 2 2 0 Protein Family FAM60A TFIIA PF03153.13 CRG88889.1 - 1.5 8.8 24.2 1.4 8.8 11.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DivIC PF04977.15 CRG88889.1 - 2.5 7.9 18.1 0.4 10.5 0.1 3.4 3 0 0 3 3 3 0 Septum formation initiator DZR PF12773.7 CRG88889.1 - 5.4 7.1 7.2 12 6.0 7.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon BTB PF00651.31 CRG88890.1 - 9.4e-16 58.0 0.2 7.4e-15 55.1 0.1 2.4 2 1 0 2 2 2 1 BTB/POZ domain His_Phos_1 PF00300.22 CRG88891.1 - 7.1e-22 78.0 0.1 8.5e-20 71.3 0.1 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DASH_Hsk3 PF08227.11 CRG88892.1 - 3.6e-21 75.2 0.7 5.2e-21 74.7 0.7 1.3 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like DUF2205 PF10224.9 CRG88892.1 - 0.037 14.0 0.1 0.16 12.0 0.1 2.0 1 1 0 1 1 1 0 Short coiled-coil protein BBS2_C PF14782.6 CRG88892.1 - 0.047 12.4 0.0 0.054 12.3 0.0 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal FlxA PF14282.6 CRG88892.1 - 0.061 13.3 0.7 0.09 12.8 0.7 1.2 1 0 0 1 1 1 0 FlxA-like protein RE_XamI PF09572.10 CRG88892.1 - 0.095 12.4 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 XamI restriction endonuclease FTA4 PF13093.6 CRG88892.1 - 0.096 12.6 0.3 0.12 12.3 0.3 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 ApbA PF02558.16 CRG88893.1 - 7.6e-25 87.3 0.0 1.2e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 CRG88893.1 - 7.6e-23 81.1 0.1 1.5e-22 80.1 0.0 1.6 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal DEAD PF00270.29 CRG88894.1 - 7.4e-38 130.1 0.1 1.4e-37 129.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG88894.1 - 2.7e-26 92.1 0.1 1.3e-23 83.5 0.0 2.6 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 CRG88894.1 - 7.6e-09 35.8 0.0 1.5e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 CRG88894.1 - 0.0012 18.3 0.1 0.0051 16.2 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DUF1664 PF07889.12 CRG88895.1 - 0.0027 17.8 1.3 0.01 15.9 1.3 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1664) POX PF07526.11 CRG88895.1 - 0.013 16.1 0.2 0.016 15.8 0.2 1.3 1 0 0 1 1 1 0 Associated with HOX Fzo_mitofusin PF04799.13 CRG88895.1 - 0.014 15.0 0.5 0.022 14.3 0.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region Baculo_PEP_C PF04513.12 CRG88895.1 - 0.024 14.7 0.4 0.69 10.0 0.4 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cobalamin_bind PF01122.19 CRG88895.1 - 0.039 12.9 0.1 0.054 12.4 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein CLZ PF16526.5 CRG88895.1 - 0.046 14.1 0.6 5.8 7.4 0.1 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CdvA PF18822.1 CRG88895.1 - 0.095 12.5 1.6 0.76 9.6 1.6 2.3 1 1 0 1 1 1 0 CdvA-like coiled-coil domain Fib_alpha PF08702.10 CRG88895.1 - 0.14 12.4 1.3 0.31 11.2 1.3 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TRPM_tetra PF16519.5 CRG88895.1 - 0.58 10.3 3.5 16 5.7 0.0 3.2 1 1 3 4 4 4 0 Tetramerisation domain of TRPM Wbp11 PF09429.10 CRG88896.1 - 2.5e-22 79.0 13.8 2.5e-22 79.0 13.8 2.7 3 0 0 3 3 3 1 WW domain binding protein 11 Pkinase PF00069.25 CRG88897.1 - 5.6e-53 180.0 4.4 2e-34 119.2 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88897.1 - 6.4e-36 124.0 0.0 7.1e-25 87.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CRG88897.1 - 0.0089 15.4 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Abi_2 PF07751.11 CRG88897.1 - 0.33 11.2 3.3 2.2 8.5 0.9 2.3 2 0 0 2 2 2 0 Abi-like protein APH PF01636.23 CRG88897.1 - 0.4 10.6 3.8 1.3 8.9 0.0 2.9 2 2 0 3 3 3 0 Phosphotransferase enzyme family YscJ_FliF_C PF08345.11 CRG88897.1 - 1.5 9.1 7.0 0.25 11.6 2.9 1.8 2 0 0 2 2 2 0 Flagellar M-ring protein C-terminal Phage_GP20 PF06810.11 CRG88897.1 - 4.9 6.9 13.1 0.044 13.6 4.0 2.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 GAGA_bind PF06217.12 CRG88897.1 - 9.9 6.3 10.4 19 5.4 10.4 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family BTB PF00651.31 CRG88898.1 - 6.8e-24 84.2 0.0 1.8e-12 47.5 0.3 2.7 2 0 0 2 2 2 2 BTB/POZ domain Ank_4 PF13637.6 CRG88898.1 - 2.5e-08 34.3 0.0 9.1e-08 32.5 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG88898.1 - 4.7e-07 30.3 0.1 1.3e-06 28.9 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG88898.1 - 8.5e-07 29.1 0.0 3.3e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 CRG88898.1 - 2.7e-05 24.4 0.0 0.003 17.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 CRG88898.1 - 0.0076 16.7 0.2 0.085 13.5 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Imm68 PF15583.6 CRG88898.1 - 0.023 14.9 0.3 0.53 10.5 0.0 2.4 2 0 0 2 2 2 0 Immunity protein 68 APH PF01636.23 CRG88899.1 - 2.9e-20 73.2 0.0 4.7e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG88899.1 - 0.0001 21.8 0.0 0.29 10.5 0.0 2.2 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CRG88899.1 - 0.0018 17.9 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 CRG88899.1 - 0.0032 17.1 0.0 0.46 10.1 0.0 2.2 2 0 0 2 2 2 2 RIO1 family zf-C2H2 PF00096.26 CRG88900.1 - 3.4e-07 30.4 14.8 0.0019 18.6 4.8 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG88900.1 - 0.00024 21.4 12.5 0.0013 19.0 1.1 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG88900.1 - 0.044 14.6 13.8 1.1 10.3 4.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 CRG88900.1 - 0.31 11.2 1.9 19 5.5 0.2 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-BED PF02892.15 CRG88900.1 - 1.6 8.8 10.8 0.42 10.7 2.7 2.5 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_6 PF13912.6 CRG88900.1 - 3.6 7.7 7.1 0.45 10.6 2.4 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger F-box PF00646.33 CRG88901.1 - 1.2e-05 25.0 0.0 3.3e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG88901.1 - 0.0012 18.7 0.1 0.0026 17.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like FMO-like PF00743.19 CRG88902.1 - 1.9e-17 62.9 0.6 9.3e-17 60.6 0.2 2.2 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG88902.1 - 8.1e-14 51.6 0.0 2.1e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG88902.1 - 1.4e-09 37.6 0.0 1.6e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG88902.1 - 3.4e-07 29.8 0.0 2.3e-06 27.1 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG88902.1 - 4.8e-07 29.2 0.1 5.1e-05 22.6 0.0 3.0 3 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG88902.1 - 2.3e-05 24.1 0.0 0.012 15.2 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG88902.1 - 0.00013 22.0 0.3 0.0024 17.9 0.0 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CRG88902.1 - 0.048 12.7 0.0 0.066 12.3 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CRG88902.1 - 0.051 12.3 0.0 0.52 9.0 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 CRG88902.1 - 0.19 10.9 0.0 6 6.0 0.0 2.3 2 0 0 2 2 2 0 Thi4 family Fungal_trans PF04082.18 CRG88903.1 - 2.3e-09 36.7 0.8 5.1e-09 35.6 0.8 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG88903.1 - 3.7e-07 30.2 11.0 3.7e-07 30.2 11.0 2.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 CRG88903.1 - 5.4e-06 26.6 14.9 0.003 17.9 5.3 3.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG88903.1 - 0.0043 17.4 3.4 0.0043 17.4 3.4 4.0 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG88903.1 - 0.022 15.6 3.4 0.022 15.6 3.4 4.3 5 0 0 5 5 5 0 C2H2-type zinc finger zf-met PF12874.7 CRG88903.1 - 0.51 10.8 0.1 0.51 10.8 0.1 2.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CRG88903.1 - 7.5 6.7 11.2 9.5 6.3 2.2 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger adh_short PF00106.25 CRG88904.1 - 1.9e-37 128.6 0.1 2.7e-37 128.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG88904.1 - 5.3e-30 104.7 0.0 7.3e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG88904.1 - 4.5e-09 36.5 0.0 1.1e-08 35.2 0.0 1.6 2 0 0 2 2 2 1 KR domain Methyltransf_25 PF13649.6 CRG88904.1 - 0.1 13.3 0.0 0.21 12.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Glyco_hydro_28 PF00295.17 CRG88905.1 - 2.2e-48 165.0 8.7 3.6e-48 164.3 8.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 MFS_1 PF07690.16 CRG88905.1 - 4.2e-28 98.3 22.5 7.4e-28 97.5 22.5 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88905.1 - 2.2e-06 26.8 20.5 0.00039 19.4 20.4 3.0 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 CRG88905.1 - 4.6e-06 25.3 2.0 7.6e-06 24.6 2.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) AAA PF00004.29 CRG88906.1 - 1.5e-39 135.4 0.0 6.4e-38 130.2 0.0 3.2 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG88906.1 - 1e-09 38.0 0.0 3.3e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 CRG88906.1 - 3.5e-05 24.3 2.9 0.00077 19.9 0.1 3.6 2 2 1 4 4 4 1 AAA ATPase domain RuvB_N PF05496.12 CRG88906.1 - 3.8e-05 23.5 0.0 0.00014 21.6 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CRG88906.1 - 5.7e-05 23.3 0.2 0.0027 17.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG88906.1 - 0.00017 21.9 0.9 0.055 13.7 0.1 3.5 2 1 1 3 3 3 1 AAA domain RMI1_N PF08585.12 CRG88906.1 - 0.00043 20.1 0.9 0.0094 15.7 0.2 2.6 2 0 0 2 2 2 1 RecQ mediated genome instability protein AAA_5 PF07728.14 CRG88906.1 - 0.00067 19.7 0.0 0.0045 17.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CRG88906.1 - 0.00081 18.7 0.0 0.0017 17.6 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 CRG88906.1 - 0.0025 17.8 0.0 0.028 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CRG88906.1 - 0.006 16.8 0.1 0.032 14.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CRG88906.1 - 0.0083 15.6 0.1 1.1 8.6 0.0 3.5 4 0 0 4 4 4 1 Bacterial TniB protein IstB_IS21 PF01695.17 CRG88906.1 - 0.0096 15.7 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 CRG88906.1 - 0.015 15.8 0.0 0.04 14.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 CRG88906.1 - 0.026 14.9 0.0 0.079 13.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 CRG88906.1 - 0.028 13.8 0.0 0.069 12.5 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CRG88906.1 - 0.075 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CRG88906.1 - 0.093 13.1 0.0 0.29 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 CRG88906.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 CRG88906.1 - 0.2 11.3 0.0 0.91 9.2 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF4050 PF13259.6 CRG88907.1 - 2.5e-51 174.6 0.2 2.5e-51 174.6 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4050) Hamartin PF04388.12 CRG88907.1 - 9.6 4.7 11.7 12 4.4 11.7 1.1 1 0 0 1 1 1 0 Hamartin protein AATase PF07247.12 CRG88908.1 - 1.9e-14 53.1 0.1 3.9e-08 32.3 0.0 3.1 3 0 0 3 3 3 2 Alcohol acetyltransferase WES_acyltransf PF03007.16 CRG88908.1 - 0.045 13.5 0.4 0.093 12.5 0.4 1.5 1 0 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 CRG88908.1 - 0.67 8.6 2.9 9.4 4.8 0.1 2.1 2 0 0 2 2 2 0 Condensation domain DUF3237 PF11578.8 CRG88909.1 - 5e-34 117.3 0.0 6.9e-34 116.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) zf-BED PF02892.15 CRG88909.1 - 0.0016 18.4 3.7 0.41 10.7 0.7 2.4 2 0 0 2 2 2 2 BED zinc finger Zn_Tnp_IS91 PF14319.6 CRG88909.1 - 0.032 14.3 6.8 0.84 9.7 0.6 2.2 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-C2H2_2 PF12756.7 CRG88909.1 - 0.38 11.1 6.1 8.5 6.8 0.4 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) PHD_4 PF16866.5 CRG88909.1 - 8 6.6 6.7 21 5.3 0.5 2.3 2 0 0 2 2 2 0 PHD-finger NAT PF04768.13 CRG88910.1 - 5.5e-56 188.9 0.1 1.1e-55 187.9 0.1 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Synaptobrevin PF00957.21 CRG88910.1 - 1.1e-32 111.6 1.0 2.3e-32 110.6 1.0 1.6 1 0 0 1 1 1 1 Synaptobrevin Semialdhyde_dh PF01118.24 CRG88910.1 - 6.6e-30 104.0 0.0 1.9e-29 102.5 0.0 1.9 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Rad21_Rec8_N PF04825.13 CRG88910.1 - 1.9e-28 98.8 0.0 5e-28 97.5 0.0 1.7 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein AA_kinase PF00696.28 CRG88910.1 - 1e-27 97.3 0.0 1.8e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family Rad21_Rec8 PF04824.16 CRG88910.1 - 0.0034 16.6 0.3 0.0084 15.4 0.3 1.6 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein LIM_bind PF01803.16 CRG88911.1 - 3.5e-55 187.2 0.3 3.5e-55 187.2 0.3 4.5 2 1 0 2 2 2 1 LIM-domain binding protein NAGLU_C PF12972.7 CRG88911.1 - 0.024 14.2 0.0 0.024 14.2 0.0 2.0 2 0 0 2 2 2 0 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain cobW PF02492.19 CRG88912.1 - 6.5e-33 113.8 0.0 7.9e-33 113.5 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 CRG88912.1 - 3.6e-05 22.9 0.1 0.015 14.3 0.0 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 CRG88912.1 - 0.027 14.6 0.0 0.077 13.1 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG88912.1 - 0.028 14.0 0.0 7.1 6.1 0.0 2.7 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain NACHT PF05729.12 CRG88912.1 - 0.036 14.0 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain CbiA PF01656.23 CRG88912.1 - 0.09 12.8 0.0 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ResIII PF04851.15 CRG88912.1 - 0.091 12.8 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 CRG88912.1 - 0.13 12.1 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 CRG88912.1 - 0.15 12.6 0.0 0.19 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain RIBIOP_C PF04950.12 CRG88913.1 - 2.1e-110 368.7 0.2 4.4e-110 367.7 0.0 1.6 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 CRG88913.1 - 2.8e-22 78.6 0.0 7.1e-22 77.3 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain HlyD PF00529.20 CRG88913.1 - 0.074 13.0 0.0 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 HlyD membrane-fusion protein of T1SS BING4CT PF08149.11 CRG88914.1 - 1.4e-39 133.8 0.0 1.3e-35 121.1 0.0 3.2 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 CRG88914.1 - 1.7e-07 31.4 0.3 2 8.7 0.0 5.9 2 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG88914.1 - 0.00055 20.7 0.0 2.4 9.2 0.0 3.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 CRG88914.1 - 0.04 13.0 0.0 0.33 9.9 0.0 2.1 2 0 0 2 2 2 0 Coatomer WD associated region SNAP PF14938.6 CRG88915.1 - 1.5e-109 365.8 11.2 1.9e-109 365.5 11.2 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_7 PF13176.6 CRG88915.1 - 0.00011 22.0 5.8 0.65 10.2 0.9 5.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG88915.1 - 0.00063 20.0 9.3 0.0024 18.1 1.2 4.4 3 2 1 4 4 4 1 Tetratricopeptide repeat FRB_dom PF08771.11 CRG88915.1 - 0.082 13.3 0.9 0.17 12.3 0.3 1.8 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain TPR_10 PF13374.6 CRG88915.1 - 0.48 10.4 4.6 5.2 7.1 0.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88915.1 - 2.7 8.3 16.7 2.9 8.2 0.3 6.7 5 3 1 7 7 7 0 Tetratricopeptide repeat NSF PF02071.20 CRG88915.1 - 4.9 8.4 16.2 1.6 9.8 0.3 6.0 6 1 1 7 7 7 0 Aromatic-di-Alanine (AdAR) repeat TPR_11 PF13414.6 CRG88915.1 - 8.6 6.1 15.1 0.98 9.2 0.8 4.9 5 0 0 5 5 5 0 TPR repeat TPR_1 PF00515.28 CRG88915.1 - 9.8 6.2 12.6 7.5 6.6 0.1 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Glu-tRNAGln PF02686.15 CRG88916.1 - 4.1e-08 33.4 2.8 3.2e-07 30.5 1.8 2.5 2 1 0 2 2 2 1 Glu-tRNAGln amidotransferase C subunit DUF726 PF05277.12 CRG88917.1 - 4.8e-115 384.1 1.8 6.4e-115 383.7 1.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Thioesterase PF00975.20 CRG88917.1 - 0.0013 18.9 0.2 0.0053 16.9 0.0 2.0 2 0 0 2 2 2 1 Thioesterase domain DUF900 PF05990.12 CRG88917.1 - 0.0075 15.8 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) DUF3089 PF11288.8 CRG88917.1 - 0.019 14.5 0.0 0.045 13.3 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PE-PPE PF08237.11 CRG88917.1 - 0.13 11.7 0.0 0.69 9.4 0.0 2.0 2 0 0 2 2 2 0 PE-PPE domain Abhydrolase_6 PF12697.7 CRG88917.1 - 0.22 12.1 3.7 1.6 9.3 0.1 2.3 1 1 0 2 2 2 0 Alpha/beta hydrolase family DUF2784 PF10861.8 CRG88918.1 - 0.05 13.6 1.1 0.11 12.6 1.1 1.5 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) Pyr_redox_2 PF07992.14 CRG88919.1 - 7.5e-08 31.9 0.0 2.8e-07 30.1 0.0 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG88919.1 - 0.034 14.4 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG88919.1 - 0.096 11.4 0.0 0.17 10.5 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein PH PF00169.29 CRG88920.1 - 0.099 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 PH domain Sec62 PF03839.16 CRG88921.1 - 3.4e-74 249.0 0.3 3.4e-74 249.0 0.3 2.1 2 0 0 2 2 2 1 Translocation protein Sec62 MPM1 PF17234.2 CRG88921.1 - 0.00026 21.3 1.1 0.19 12.0 0.7 2.2 2 0 0 2 2 2 2 Mitochondrial peculiar membrane protein 1 HTH_18 PF12833.7 CRG88921.1 - 0.13 12.5 0.3 0.67 10.3 0.2 2.1 1 1 1 2 2 2 0 Helix-turn-helix domain PhyH PF05721.13 CRG88921.1 - 0.5 10.6 5.1 0.86 9.8 5.1 1.3 1 0 0 1 1 1 0 Phytanoyl-CoA dioxygenase (PhyH) Ctr PF04145.15 CRG88921.1 - 5.3 7.6 6.4 33 5.1 2.6 3.0 3 0 0 3 3 3 0 Ctr copper transporter family Lectin_C PF00059.21 CRG88922.1 - 0.0015 19.2 0.1 0.0042 17.8 0.1 1.8 1 0 0 1 1 1 1 Lectin C-type domain HNOB PF07700.15 CRG88922.1 - 0.0059 16.6 0.0 0.0099 15.8 0.0 1.2 1 0 0 1 1 1 1 Haem-NO-binding PriC PF07445.12 CRG88923.1 - 0.00037 20.5 4.8 0.00037 20.5 4.8 1.7 2 0 0 2 2 2 1 Primosomal replication protein priC Atg14 PF10186.9 CRG88923.1 - 0.0055 15.8 1.7 0.0055 15.8 1.7 2.0 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Pox_A_type_inc PF04508.12 CRG88923.1 - 0.037 13.9 1.1 0.037 13.9 1.1 1.8 2 0 0 2 2 1 0 Viral A-type inclusion protein repeat DUF2046 PF09755.9 CRG88923.1 - 0.047 12.9 6.3 0.15 11.3 4.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) TetR_C_13 PF16925.5 CRG88923.1 - 0.13 12.2 1.6 0.25 11.3 1.6 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TMCO5 PF14992.6 CRG88923.1 - 0.49 9.9 0.1 0.49 9.9 0.1 2.0 2 0 0 2 2 2 0 TMCO5 family Cnn_1N PF07989.11 CRG88923.1 - 0.81 9.9 0.0 0.81 9.9 0.0 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Jnk-SapK_ap_N PF09744.9 CRG88923.1 - 0.88 9.8 10.1 3 8.1 0.1 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Lin-8 PF03353.15 CRG88923.1 - 0.9 9.0 4.9 1.9 8.0 4.9 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Spt20 PF12090.8 CRG88923.1 - 1.3 8.6 10.3 2.1 7.9 10.3 1.4 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 CRG88923.1 - 2.6 7.9 16.8 3.7 7.4 16.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4407 PF14362.6 CRG88923.1 - 3.3 7.0 7.8 3.3 7.0 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Methyltransf_25 PF13649.6 CRG88924.1 - 4.6e-21 75.3 0.0 1.2e-20 74.1 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG88924.1 - 2e-20 73.2 0.0 3.8e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG88924.1 - 4.1e-20 72.1 0.0 5.6e-20 71.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG88924.1 - 9.7e-16 58.0 0.0 1.5e-15 57.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG88924.1 - 9.7e-14 51.9 0.0 2.3e-13 50.7 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG88924.1 - 1.7e-10 40.7 0.0 3.5e-10 39.6 0.0 1.4 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CRG88924.1 - 1.4e-07 31.2 0.0 2.2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CRG88924.1 - 5.9e-06 26.2 0.0 8e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 CRG88924.1 - 0.00038 20.0 0.0 0.0021 17.5 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_18 PF12847.7 CRG88924.1 - 0.0012 18.7 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CRG88924.1 - 0.0033 16.8 0.0 0.0055 16.0 0.0 1.3 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CRG88924.1 - 0.0041 16.6 0.0 0.0056 16.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_PK PF05891.12 CRG88924.1 - 0.0042 16.6 0.0 0.006 16.1 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_32 PF13679.6 CRG88924.1 - 0.0045 17.0 0.0 0.0068 16.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 CRG88924.1 - 0.0052 16.6 0.0 0.0075 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) RrnaAD PF00398.20 CRG88924.1 - 0.0067 15.5 0.0 0.0094 15.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_29 PF03141.16 CRG88924.1 - 0.016 13.8 0.0 0.047 12.2 0.0 1.7 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase CheR PF01739.18 CRG88924.1 - 0.018 14.6 0.0 1.9 8.0 0.0 2.3 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain MetW PF07021.12 CRG88924.1 - 0.02 14.5 0.0 0.045 13.3 0.0 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 CRG88924.1 - 0.026 14.4 0.0 0.43 10.4 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase Methyltr_RsmB-F PF01189.17 CRG88924.1 - 0.049 13.3 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_9 PF08003.11 CRG88924.1 - 0.058 12.3 0.0 0.09 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) NodS PF05401.11 CRG88924.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) FtsJ PF01728.19 CRG88924.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_10 PF05971.12 CRG88924.1 - 0.21 10.9 0.0 0.31 10.3 0.0 1.1 1 0 0 1 1 1 0 RNA methyltransferase DOT1 PF08123.13 CRG88924.1 - 0.23 10.9 0.0 0.36 10.3 0.0 1.2 1 0 0 1 1 1 0 Histone methylation protein DOT1 ADH_N PF08240.12 CRG88925.1 - 2.2e-27 95.1 1.1 8.6e-27 93.2 0.5 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 CRG88925.1 - 3.6e-06 26.8 0.1 3.6e-06 26.8 0.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 CRG88925.1 - 5.8e-06 26.3 0.0 0.00052 20.0 0.0 2.5 2 0 0 2 2 2 2 Zinc-binding dehydrogenase EHN PF06441.12 CRG88926.1 - 1.1e-24 86.8 0.1 2e-24 86.0 0.1 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG88926.1 - 8.6e-10 38.7 0.1 2.7e-09 37.1 0.0 1.7 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG88926.1 - 0.05 14.2 8.0 0.028 15.0 4.2 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase family Carn_acyltransf PF00755.20 CRG88927.1 - 3.2e-207 689.8 0.0 3.7e-207 689.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase tRNA-synt_1 PF00133.22 CRG88928.1 - 1.9e-208 693.6 0.0 4.1e-207 689.2 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CRG88928.1 - 4.6e-29 101.4 0.1 1.3e-28 99.9 0.0 1.8 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CRG88928.1 - 2.7e-15 56.0 0.1 4.4e-05 22.4 0.0 4.7 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CRG88928.1 - 2.3e-10 40.3 3.4 3.7e-08 33.1 0.0 3.3 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 PAD_N PF08526.10 CRG88928.1 - 0.036 14.4 0.0 0.08 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) N-terminal domain tRNA-synt_1e PF01406.19 CRG88928.1 - 0.045 13.1 3.2 0.23 10.8 0.0 2.6 3 0 0 3 3 2 0 tRNA synthetases class I (C) catalytic domain SUIM_assoc PF16619.5 CRG88928.1 - 0.42 10.7 15.9 1 9.5 15.9 1.6 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF4054 PF13262.6 CRG88928.1 - 0.45 10.6 5.3 1.1 9.3 5.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) CNDH2_M PF16869.5 CRG88928.1 - 0.7 10.6 4.3 1.5 9.5 4.3 1.5 1 0 0 1 1 1 0 PF16858 Spt20 PF12090.8 CRG88928.1 - 6.1 6.4 16.9 10 5.6 16.9 1.3 1 0 0 1 1 1 0 Spt20 family DUF2967 PF11179.8 CRG88928.1 - 7.9 4.4 7.3 10 4.1 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Rxt3 PF08642.10 CRG88929.1 - 4.5e-39 134.1 0.0 2.1e-38 132.0 0.0 2.2 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 CRG88929.1 - 0.0016 18.5 0.0 0.0046 17.0 0.0 1.7 2 0 0 2 2 2 1 LCCL domain CLN3 PF02487.17 CRG88930.1 - 1.6e-154 514.8 6.3 3.2e-154 513.8 6.3 1.5 1 0 0 1 1 1 1 CLN3 protein Abhydrolase_3 PF07859.13 CRG88930.1 - 7.5e-37 127.2 0.0 1.9e-26 93.2 0.0 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG88930.1 - 0.19 10.5 0.0 0.33 9.8 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Aminotran_3 PF00202.21 CRG88931.1 - 1.1e-108 363.5 0.0 1.5e-108 363.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CRG88931.1 - 0.0035 16.6 0.0 0.0056 15.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF1674 PF07896.12 CRG88932.1 - 1.6e-19 70.1 3.1 1.6e-19 70.1 3.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1674) MSA_2 PF00985.17 CRG88932.1 - 0.02 15.3 2.1 0.022 15.1 2.1 1.1 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family HMGL-like PF00682.19 CRG88933.1 - 2.3e-46 158.5 0.5 4.7e-46 157.5 0.5 1.5 1 1 0 1 1 1 1 HMGL-like PE PF00934.20 CRG88933.1 - 0.63 10.4 4.6 0.24 11.7 0.8 2.3 2 1 0 2 2 2 0 PE family Diphthamide_syn PF01866.17 CRG88934.1 - 4.9e-116 387.4 0.0 6.1e-116 387.1 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Bromodomain PF00439.25 CRG88935.1 - 6.9e-08 32.5 0.0 9e-07 28.9 0.0 2.4 1 1 0 1 1 1 1 Bromodomain OSCP PF00213.18 CRG88936.1 - 5.6e-47 160.0 3.6 8.8e-47 159.4 3.6 1.3 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF148 PF02520.17 CRG88936.1 - 0.014 15.5 0.5 0.062 13.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF1539 PF07560.11 CRG88936.1 - 0.089 12.9 0.3 6.3 6.9 0.1 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) DrrA_P4M PF14860.6 CRG88936.1 - 0.092 12.6 0.8 0.43 10.5 0.0 2.4 1 1 2 3 3 3 0 DrrA phosphatidylinositol 4-phosphate binding domain Glyco_hydro_63 PF03200.16 CRG88937.1 - 7.9e-09 34.8 1.8 7.9e-09 34.8 1.8 3.6 4 1 0 4 4 4 1 Glycosyl hydrolase family 63 C-terminal domain SlyX PF04102.12 CRG88938.1 - 0.015 15.9 1.6 0.024 15.2 1.6 1.3 1 0 0 1 1 1 0 SlyX ABC_tran_CTD PF16326.5 CRG88938.1 - 0.063 13.5 3.2 0.11 12.8 0.6 2.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain DASH_Spc19 PF08287.11 CRG88938.1 - 0.1 12.5 6.9 0.19 11.6 6.9 1.7 1 1 0 1 1 1 0 Spc19 Uds1 PF15456.6 CRG88938.1 - 0.27 11.4 6.1 0.44 10.7 6.1 1.5 1 1 0 1 1 1 0 Up-regulated During Septation DUF4592 PF15262.6 CRG88938.1 - 0.59 10.8 7.7 0.94 10.2 7.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4592) Rgp1 PF08737.10 CRG88939.1 - 1.6e-139 465.7 0.0 2.6e-139 465.0 0.0 1.4 1 0 0 1 1 1 1 Rgp1 Mob1_phocein PF03637.17 CRG88939.1 - 3e-70 235.6 0.0 5e-70 234.9 0.0 1.3 1 0 0 1 1 1 1 Mob1/phocein family Arrestin_N PF00339.29 CRG88939.1 - 0.0001 22.4 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 CRG88939.1 - 0.082 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 SpoOM protein Neugrin PF06413.11 CRG88940.1 - 4.3e-16 59.6 2.4 4.3e-16 59.6 2.4 2.1 2 1 1 3 3 3 1 Neugrin MRP-L20 PF12824.7 CRG88940.1 - 2.6e-05 24.5 6.4 3.4e-05 24.0 5.3 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Glyco_hydro_30 PF02055.16 CRG88941.1 - 6e-37 127.4 7.6 7.9e-37 127.0 7.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 CRG88941.1 - 6.4e-08 32.7 0.3 2.9e-07 30.6 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydr_30_2 PF14587.6 CRG88941.1 - 1.2e-07 31.7 0.1 3.1e-07 30.3 0.1 1.6 1 1 0 1 1 1 1 O-Glycosyl hydrolase family 30 Glyco_hydro_71 PF03659.14 CRG88942.1 - 2.5e-100 335.9 2.4 2.9e-100 335.7 2.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 DUF1493 PF07377.12 CRG88942.1 - 0.18 12.3 0.1 0.34 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) Malate_synthase PF01274.22 CRG88942.1 - 0.19 10.0 0.0 0.26 9.5 0.0 1.1 1 0 0 1 1 1 0 Malate synthase FlgD_ig PF13860.6 CRG88942.1 - 0.67 9.9 5.4 0.42 10.5 0.6 2.7 2 1 1 3 3 3 0 FlgD Ig-like domain WD40 PF00400.32 CRG88943.1 - 3e-14 53.2 9.9 0.014 16.3 0.0 8.2 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG88943.1 - 0.00013 22.1 0.4 12 6.3 0.0 5.4 5 1 0 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Sec23_trunk PF04811.15 CRG88943.1 - 0.063 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain Zn_clus PF00172.18 CRG88944.1 - 2e-05 24.6 10.0 3.4e-05 23.9 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-Q PF13094.6 CRG88945.1 - 1.2e-42 146.0 9.1 1.2e-42 146.0 9.1 1.9 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit OTU PF02338.19 CRG88945.1 - 0.036 14.6 0.2 0.6 10.6 0.0 2.2 2 0 0 2 2 2 0 OTU-like cysteine protease ProSAAS PF07259.12 CRG88945.1 - 0.32 10.9 3.0 0.44 10.5 3.0 1.4 1 0 0 1 1 1 0 ProSAAS precursor Cas_Csy4 PF09618.10 CRG88945.1 - 4.8 7.3 7.0 0.87 9.7 0.4 2.3 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) HLH PF00010.26 CRG88946.1 - 6.6e-08 32.4 0.0 1.5e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ORC6 PF05460.13 CRG88946.1 - 6.3 6.0 11.8 10 5.3 11.8 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TMEM135_C_rich PF15982.5 CRG88947.1 - 7.4e-06 26.6 5.3 4.8e-05 24.0 0.7 3.3 3 2 0 3 3 3 1 N-terminal cysteine-rich region of Transmembrane protein 135 Cation_ATPase_C PF00689.21 CRG88947.1 - 0.045 13.4 0.2 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus MFS_1 PF07690.16 CRG88948.1 - 5.8e-38 130.7 27.5 5.8e-38 130.7 27.5 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88948.1 - 2.3e-12 46.5 11.2 3.3e-12 46.0 5.9 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter Condensation PF00668.20 CRG88949.1 - 6e-17 61.5 0.4 1.6e-13 50.1 0.0 2.2 1 1 1 2 2 2 2 Condensation domain PP-binding PF00550.25 CRG88949.1 - 3.6e-11 43.2 0.0 9.2e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Zn_clus PF00172.18 CRG88949.1 - 1.9e-07 31.1 10.4 3.3e-07 30.3 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG88949.1 - 3.4e-07 29.6 0.3 6.4e-07 28.7 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain AMP-binding_C PF13193.6 CRG88949.1 - 0.0018 19.2 0.0 0.0042 18.0 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CtaG_Cox11 PF04442.14 CRG88950.1 - 2e-61 206.5 0.0 3.1e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 EHN PF06441.12 CRG88951.1 - 1.2e-16 61.0 0.3 6.7e-13 48.9 0.0 3.0 3 0 0 3 3 3 2 Epoxide hydrolase N terminus DNA_pol3_delta2 PF13177.6 CRG88951.1 - 1.6e-10 41.0 0.1 3.5e-10 39.9 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Abhydrolase_1 PF00561.20 CRG88951.1 - 1.3e-08 34.8 0.0 3e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold AAA PF00004.29 CRG88951.1 - 4.5e-06 27.1 0.1 1.2e-05 25.8 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG88951.1 - 2.7e-05 24.5 0.0 9.2e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 CRG88951.1 - 0.0038 17.0 0.2 0.0083 15.9 0.2 1.5 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG88951.1 - 0.0046 17.4 0.4 0.022 15.2 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain Rep_fac_C PF08542.11 CRG88951.1 - 0.012 16.0 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 Replication factor C C-terminal domain Rad17 PF03215.15 CRG88951.1 - 0.036 14.0 0.0 0.17 11.8 0.0 2.2 3 1 0 3 3 3 0 Rad17 P-loop domain ABC_tran PF00005.27 CRG88951.1 - 0.052 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter Ribosomal_L16 PF00252.18 CRG88952.1 - 6e-31 107.2 0.1 8.7e-31 106.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e RFC1 PF08519.12 CRG88953.1 - 1.5e-59 200.6 0.0 1.8e-58 197.1 0.0 2.3 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 CRG88953.1 - 3.3e-16 59.4 0.0 1.1e-15 57.8 0.0 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 CRG88953.1 - 1.9e-09 38.0 1.0 3.8e-09 37.1 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 CRG88953.1 - 2.7e-05 24.2 0.1 8.8e-05 22.5 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 CRG88953.1 - 3.3e-05 24.2 0.0 7.9e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG88953.1 - 0.0014 19.1 0.8 0.014 15.8 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 CRG88953.1 - 0.0024 18.1 0.4 0.0077 16.4 0.1 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 CRG88953.1 - 0.0036 17.1 0.0 0.0079 16.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 CRG88953.1 - 0.0088 15.8 0.0 0.0088 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CRG88953.1 - 0.01 16.1 0.9 0.12 12.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CRG88953.1 - 0.011 15.8 0.0 0.85 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) PTCB-BRCT PF12738.7 CRG88953.1 - 0.096 12.6 0.0 0.26 11.2 0.0 1.8 1 0 0 1 1 1 0 twin BRCT domain AAA_14 PF13173.6 CRG88953.1 - 0.12 12.4 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 CRG88953.1 - 0.15 11.7 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 CRG88953.1 - 0.16 11.9 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 CRG88953.1 - 0.19 12.3 1.7 0.31 11.6 0.1 2.3 2 0 0 2 2 1 0 AAA domain CRIM PF16978.5 CRG88954.1 - 9.6e-41 139.2 0.0 2e-40 138.2 0.0 1.6 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 CRG88954.1 - 7.9e-27 93.7 0.2 1.4e-26 92.9 0.2 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology TUG-UBL1 PF11470.8 CRG88954.1 - 0.0046 17.2 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 TUG ubiquitin-like domain RBD PF02196.15 CRG88954.1 - 0.055 13.6 0.1 0.17 12.0 0.1 1.9 1 0 0 1 1 1 0 Raf-like Ras-binding domain Pkinase PF00069.25 CRG88955.1 - 7.6e-73 245.1 0.0 1.1e-72 244.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG88955.1 - 1.7e-37 129.1 0.0 2.4e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG88955.1 - 6.5e-06 25.7 0.1 1.1e-05 25.0 0.1 1.5 1 1 0 1 1 1 1 Kinase-like Rad21_Rec8 PF04824.16 CRG88955.1 - 0.78 9.1 6.1 0.9 8.9 0.1 2.8 3 0 0 3 3 3 0 Conserved region of Rad21 / Rec8 like protein SpoIIIAH PF12685.7 CRG88955.1 - 5.4 6.8 17.6 7.9 6.2 17.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein zf-Tim10_DDP PF02953.15 CRG88956.1 - 3e-22 78.0 0.3 4e-22 77.6 0.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger RNF111_N PF15303.6 CRG88956.1 - 0.0046 16.8 2.3 0.0052 16.6 2.3 1.1 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase Arkadia N-terminus Lectin_leg-like PF03388.13 CRG88957.1 - 3.6e-69 232.6 0.1 4.6e-69 232.3 0.1 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 CRG88957.1 - 0.0044 16.6 0.1 0.21 11.1 0.1 2.2 1 1 0 1 1 1 1 Legume lectin domain SARAF PF06682.12 CRG88958.1 - 6.5 6.3 22.0 1.2 8.8 18.4 1.6 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis PRCC PF10253.9 CRG88959.1 - 3.7e-38 132.5 15.1 3.7e-38 132.5 15.1 2.8 1 1 0 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting AAA_5 PF07728.14 CRG88960.1 - 1.2e-126 417.3 0.1 2.3e-21 76.3 0.0 9.9 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 CRG88960.1 - 8.1e-49 164.2 10.5 5.7e-19 68.3 0.0 5.6 5 0 0 5 5 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 CRG88960.1 - 2.1e-29 101.7 0.1 4.9e-28 97.3 0.0 3.5 4 0 0 4 4 2 1 Midasin AAA lid domain AAA_7 PF12775.7 CRG88960.1 - 1.5e-28 99.6 1.5 2.4e-06 27.2 0.0 7.0 7 0 0 7 7 7 6 P-loop containing dynein motor region AAA_3 PF07726.11 CRG88960.1 - 6.6e-28 97.2 0.0 1.1e-11 44.7 0.0 7.0 7 0 0 7 7 7 3 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 CRG88960.1 - 1.9e-26 93.1 0.1 3.2e-05 24.3 0.0 7.4 7 0 0 7 7 6 5 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG88960.1 - 8.8e-25 88.0 13.7 0.00051 20.5 0.1 8.7 7 1 0 7 7 6 5 AAA ATPase domain Dynein_heavy PF03028.15 CRG88960.1 - 1.1e-21 77.1 0.0 4.3e-06 26.8 0.0 8.4 7 1 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 CRG88960.1 - 2e-20 73.1 0.0 0.014 14.4 0.0 8.2 9 0 0 9 9 9 4 Hydrolytic ATP binding site of dynein motor region Sigma54_activat PF00158.26 CRG88960.1 - 9.4e-17 61.2 0.0 0.0053 16.5 0.0 6.0 6 0 0 6 6 6 4 Sigma-54 interaction domain AAA_22 PF13401.6 CRG88960.1 - 2.6e-16 60.1 0.1 0.051 13.9 0.0 7.8 7 0 0 7 7 6 4 AAA domain AAA_33 PF13671.6 CRG88960.1 - 4.8e-16 59.2 0.0 0.00098 19.3 0.0 6.8 6 1 0 6 6 6 3 AAA domain AAA_14 PF13173.6 CRG88960.1 - 1.3e-15 57.6 0.0 0.0054 16.8 0.0 7.9 8 0 0 8 8 8 2 AAA domain ABC_tran PF00005.27 CRG88960.1 - 9.9e-14 52.0 3.2 0.059 13.9 0.0 7.9 7 0 0 7 7 7 2 ABC transporter TsaE PF02367.17 CRG88960.1 - 1.5e-13 50.8 1.3 0.066 13.2 0.0 6.6 6 0 0 6 6 6 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 CRG88960.1 - 2.4e-13 50.3 0.0 0.019 14.7 0.0 7.2 6 1 0 6 6 6 2 AAA domain AAA_18 PF13238.6 CRG88960.1 - 8e-13 49.1 3.8 0.024 15.2 0.0 8.0 7 0 0 7 7 6 2 AAA domain Sigma54_activ_2 PF14532.6 CRG88960.1 - 7.1e-12 45.6 0.7 0.0049 17.0 0.0 5.2 5 0 0 5 5 4 2 Sigma-54 interaction domain RNA_helicase PF00910.22 CRG88960.1 - 1.7e-11 44.5 0.9 0.47 10.9 0.0 6.7 6 0 0 6 6 6 2 RNA helicase Zeta_toxin PF06414.12 CRG88960.1 - 5.8e-11 42.1 5.8 4 6.7 0.0 8.1 9 0 0 9 9 7 0 Zeta toxin Rad17 PF03215.15 CRG88960.1 - 1.5e-10 41.3 0.3 0.16 11.9 0.0 5.8 5 0 0 5 5 5 1 Rad17 P-loop domain NACHT PF05729.12 CRG88960.1 - 5.5e-10 39.4 4.0 0.06 13.3 0.0 5.8 6 0 0 6 6 5 2 NACHT domain AAA_19 PF13245.6 CRG88960.1 - 1.6e-09 38.2 0.3 2.6 8.4 0.0 6.4 6 0 0 6 6 5 1 AAA domain Mg_chelatase PF01078.21 CRG88960.1 - 2.1e-09 37.1 1.4 9.9 5.5 0.0 8.2 8 0 0 8 8 8 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 CRG88960.1 - 1.1e-08 34.5 0.4 0.0028 16.7 0.0 5.1 5 0 0 5 5 5 1 Type II/IV secretion system protein AAA_25 PF13481.6 CRG88960.1 - 1.6e-08 34.4 1.1 1.1 8.8 0.0 5.9 6 0 0 6 6 5 2 AAA domain IstB_IS21 PF01695.17 CRG88960.1 - 2.9e-08 33.6 0.2 3.6 7.3 0.0 6.1 6 0 0 6 6 5 0 IstB-like ATP binding protein RuvB_N PF05496.12 CRG88960.1 - 1.1e-07 31.8 4.7 0.54 10.0 0.0 6.1 7 0 0 7 7 5 1 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 CRG88960.1 - 1.7e-07 30.8 0.1 5.7 6.3 0.0 6.3 6 0 0 6 6 6 0 Bacterial TniB protein ATPase_2 PF01637.18 CRG88960.1 - 2.1e-07 31.1 0.0 12 5.7 0.0 6.3 6 0 0 6 6 6 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 CRG88960.1 - 2.3e-07 30.9 9.6 0.59 10.0 0.3 6.8 7 0 0 7 7 6 2 RsgA GTPase SRP54 PF00448.22 CRG88960.1 - 2.7e-07 30.4 2.6 0.76 9.4 0.0 5.4 6 0 0 6 6 6 2 SRP54-type protein, GTPase domain AAA_28 PF13521.6 CRG88960.1 - 5e-07 30.1 3.7 0.84 9.9 0.0 5.9 6 0 0 6 6 6 2 AAA domain PduV-EutP PF10662.9 CRG88960.1 - 1.5e-06 28.0 3.5 0.19 11.5 0.0 5.8 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 CRG88960.1 - 1.6e-06 27.5 0.8 1.9 7.6 0.0 5.2 6 0 0 6 6 6 1 Protein of unknown function (DUF815) Roc PF08477.13 CRG88960.1 - 4.5e-06 26.9 1.6 13 6.0 0.0 6.3 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CRG88960.1 - 5.7e-06 26.0 1.4 13 5.7 0.0 6.0 6 0 0 6 6 6 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CRG88960.1 - 1.5e-05 25.0 1.6 0.54 10.4 0.0 5.6 6 0 0 6 6 5 1 50S ribosome-binding GTPase MCM PF00493.23 CRG88960.1 - 3.1e-05 23.2 0.1 9.4 5.3 0.0 4.8 5 0 0 5 5 5 0 MCM P-loop domain Bac_DnaA PF00308.18 CRG88960.1 - 3.8e-05 23.6 0.0 2.7 7.8 0.0 3.9 3 0 0 3 3 3 1 Bacterial dnaA protein CPT PF07931.12 CRG88960.1 - 3.9e-05 23.5 0.2 0.88 9.4 0.0 5.4 5 1 0 5 5 4 1 Chloramphenicol phosphotransferase-like protein AAA_24 PF13479.6 CRG88960.1 - 5.7e-05 22.9 0.0 9.6 5.9 0.0 6.0 7 0 0 7 7 7 0 AAA domain TIP49 PF06068.13 CRG88960.1 - 0.00027 20.3 1.7 1.9 7.6 0.0 4.5 5 0 0 5 5 5 1 TIP49 P-loop domain SRPRB PF09439.10 CRG88960.1 - 0.00066 19.2 1.3 54 3.2 0.0 5.8 6 0 0 6 6 6 0 Signal recognition particle receptor beta subunit ATPase PF06745.13 CRG88960.1 - 0.0019 17.6 0.1 10 5.4 0.0 4.2 3 0 0 3 3 3 0 KaiC DnaB_C PF03796.15 CRG88960.1 - 0.0088 15.4 4.2 3.1 7.0 0.0 4.5 4 0 0 4 4 4 1 DnaB-like helicase C terminal domain NTPase_1 PF03266.15 CRG88960.1 - 0.0099 15.8 5.6 0.67 9.8 0.0 4.9 5 0 0 5 5 4 1 NTPase PhoH PF02562.16 CRG88960.1 - 0.011 15.2 0.2 2.5 7.5 0.0 3.6 4 0 0 4 4 3 0 PhoH-like protein FeoB_N PF02421.18 CRG88960.1 - 0.019 14.5 1.3 7.5 6.1 0.0 4.3 4 0 0 4 4 4 0 Ferrous iron transport protein B ATP-synt_ab PF00006.25 CRG88960.1 - 0.02 14.5 0.0 4.7 6.8 0.0 3.6 4 0 0 4 4 4 0 ATP synthase alpha/beta family, nucleotide-binding domain KTI12 PF08433.10 CRG88960.1 - 0.026 14.0 0.0 31 3.9 0.0 4.5 4 0 0 4 4 4 0 Chromatin associated protein KTI12 dNK PF01712.19 CRG88960.1 - 0.03 14.2 0.1 7.9 6.3 0.0 3.3 3 0 0 3 3 2 0 Deoxynucleoside kinase Viral_helicase1 PF01443.18 CRG88960.1 - 0.06 13.1 0.0 24 4.6 0.0 4.1 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase CbiA PF01656.23 CRG88960.1 - 0.063 13.3 0.1 1.1 9.3 0.0 3.2 3 0 0 3 3 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 CRG88960.1 - 0.089 12.6 4.7 35 4.1 0.0 4.8 5 0 0 5 5 4 0 Conserved hypothetical ATP binding protein cobW PF02492.19 CRG88960.1 - 1.2 8.7 6.6 13 5.3 0.0 4.8 6 0 0 6 6 5 0 CobW/HypB/UreG, nucleotide-binding domain Voltage_CLC PF00654.20 CRG88961.1 - 2.2e-88 296.9 25.5 3.6e-88 296.2 25.5 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 CRG88961.1 - 0.00011 22.6 0.0 0.051 14.0 0.0 2.5 2 0 0 2 2 2 2 CBS domain P5CR_dimer PF14748.6 CRG88962.1 - 1.1e-31 109.2 2.3 2.3e-31 108.1 2.3 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CRG88962.1 - 1.1e-12 48.4 0.8 3.8e-12 46.6 0.2 2.2 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 CRG88962.1 - 0.021 14.5 0.1 0.035 13.8 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CTK3 PF12243.8 CRG88963.1 - 9.1e-51 171.0 0.3 1.3e-50 170.5 0.3 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 CRG88963.1 - 4.9e-19 68.3 11.3 4.9e-19 68.3 11.3 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus DUF3873 PF12989.7 CRG88963.1 - 0.072 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) U3_snoRNA_assoc PF08297.11 CRG88964.1 - 7.5e-14 52.2 0.1 7.5e-14 52.2 0.1 4.9 2 1 1 3 3 3 1 U3 snoRNA associated DUF155 PF02582.14 CRG88965.1 - 3.7e-52 177.0 0.0 6.6e-52 176.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 CRG88965.1 - 0.095 13.2 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 bZIP_1 PF00170.21 CRG88966.1 - 0.011 15.9 3.3 0.028 14.5 3.3 1.6 1 0 0 1 1 1 0 bZIP transcription factor Mito_carr PF00153.27 CRG88967.1 - 1.1e-45 153.5 4.3 1.7e-16 59.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 CRG88968.1 - 7.5e-38 127.9 17.9 3.7e-07 30.7 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 CRG88968.1 - 2.3e-11 43.4 0.5 6.1e-11 42.0 0.5 1.8 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 CRG88968.1 - 5.4e-07 29.8 0.5 1.2 9.4 0.0 5.5 1 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG88968.1 - 5.1e-06 25.4 6.0 0.095 11.3 0.1 5.1 1 1 5 6 6 6 2 Nucleoporin Nup120/160 Fungal_trans_2 PF11951.8 CRG88968.1 - 8.5e-05 21.5 0.2 0.00017 20.6 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain F-box_5 PF18511.1 CRG88968.1 - 0.00041 19.9 0.0 0.00073 19.0 0.0 1.4 1 0 0 1 1 1 1 F-box F-box PF00646.33 CRG88968.1 - 0.00076 19.3 0.3 0.0019 18.0 0.3 1.8 1 0 0 1 1 1 1 F-box domain PALB2_WD40 PF16756.5 CRG88968.1 - 0.0088 15.0 5.3 7.8 5.3 0.0 4.0 3 1 1 4 4 4 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 CRG88968.1 - 0.034 13.5 0.0 0.58 9.4 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain Zn_clus PF00172.18 CRG88968.1 - 0.067 13.3 1.3 0.16 12.1 1.3 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PQQ_2 PF13360.6 CRG88968.1 - 0.084 12.4 3.1 0.24 10.9 1.4 2.4 1 1 1 2 2 2 0 PQQ-like domain Zip PF02535.22 CRG88969.1 - 9.8e-39 133.5 13.1 1.2e-28 100.4 6.4 2.9 2 1 0 2 2 2 2 ZIP Zinc transporter Glyco_hydro_18 PF00704.28 CRG88970.1 - 2e-13 50.8 0.8 5.3e-13 49.4 0.8 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 APH PF01636.23 CRG88971.1 - 2.8e-07 30.7 0.0 3.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 CRG88971.1 - 0.071 12.0 0.0 0.087 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Peptidase_S10 PF00450.22 CRG88972.1 - 9.1e-91 305.3 0.0 1.2e-90 305.0 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hat1_N PF10394.9 CRG88973.1 - 4.6e-53 179.7 0.0 7.1e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 CRG88973.1 - 0.04 14.1 0.0 0.091 13.0 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family HemY_N PF07219.13 CRG88974.1 - 0.1 12.8 2.7 0.25 11.5 2.7 1.6 1 0 0 1 1 1 0 HemY protein N-terminus BatD PF13584.6 CRG88974.1 - 0.16 10.7 0.1 0.22 10.3 0.1 1.2 1 0 0 1 1 1 0 Oxygen tolerance MscS_TM PF12794.7 CRG88974.1 - 3 6.6 5.9 4.3 6.1 5.9 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 LSM PF01423.22 CRG88975.1 - 2.3e-16 59.2 0.0 5.1e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 LSM domain DSPc PF00782.20 CRG88975.1 - 1.9e-09 37.4 0.0 4.7e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PPR_2 PF13041.6 CRG88975.1 - 0.00033 20.8 0.1 4.8 7.5 0.0 4.9 4 1 1 5 5 5 1 PPR repeat family PPR_long PF17177.4 CRG88975.1 - 0.01 15.2 0.1 3.4 7.0 0.0 3.0 2 1 1 3 3 3 0 Pentacotripeptide-repeat region of PRORP PET122 PF05476.11 CRG88975.1 - 0.014 14.7 0.1 0.033 13.5 0.1 1.5 1 0 0 1 1 1 0 PET122 Y_phosphatase PF00102.27 CRG88975.1 - 0.021 14.4 0.0 0.04 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FXMRP1_C_core PF12235.8 CRG88975.1 - 0.052 14.2 18.3 9.4 6.9 10.0 3.9 4 0 0 4 4 4 0 Fragile X-related 1 protein core C terminal SM-ATX PF14438.6 CRG88975.1 - 0.1 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain PLA2_B PF01735.18 CRG88976.1 - 2e-27 95.8 0.0 3.6e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Exo70 PF03081.15 CRG88977.1 - 2e-85 287.1 0.0 5e-85 285.8 0.0 1.6 2 0 0 2 2 2 1 Exo70 exocyst complex subunit Pec_lyase PF09492.10 CRG88977.1 - 0.048 13.0 0.2 7.2 5.8 0.0 2.2 1 1 1 2 2 2 0 Pectic acid lyase Proteasome PF00227.26 CRG88981.1 - 2.5e-56 190.2 0.0 4.3e-32 111.2 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 CRG88981.1 - 0.01 15.5 0.0 0.037 13.7 0.0 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Peptidase_S13 PF02113.15 CRG88981.1 - 0.021 13.6 0.2 0.1 11.3 0.0 1.9 2 0 0 2 2 2 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family Ribonuclease_3 PF00636.26 CRG88982.1 - 2.3e-42 143.9 0.0 1.9e-23 83.1 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CRG88982.1 - 2.7e-25 89.0 0.1 4.2e-14 52.8 0.0 3.7 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.14 CRG88982.1 - 9.3e-19 67.4 0.2 2e-18 66.3 0.2 1.6 1 0 0 1 1 1 1 Dicer dimerisation domain Helicase_C PF00271.31 CRG88982.1 - 1e-17 64.5 0.0 3.1e-17 62.9 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG88982.1 - 2.8e-17 63.0 0.0 6.1e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG88982.1 - 9.2e-10 38.8 0.0 2.6e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-nanos PF05741.13 CRG88984.1 - 0.025 14.8 2.2 0.056 13.7 2.2 1.6 1 0 0 1 1 1 0 Nanos RNA binding domain DUF4303 PF14136.6 CRG88984.1 - 0.087 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4303) LSM PF01423.22 CRG88985.1 - 6.8e-17 60.9 1.2 1.2e-16 60.2 0.0 1.8 2 0 0 2 2 2 1 LSM domain Ribosomal_S17_N PF16205.5 CRG88985.1 - 0.084 13.3 0.3 0.16 12.4 0.3 1.4 1 0 0 1 1 1 0 Ribosomal_S17 N-terminal NUC173 PF08161.12 CRG88986.1 - 5.9e-79 264.5 0.6 1e-76 257.1 0.1 3.5 4 0 0 4 4 4 1 NUC173 domain HEAT_2 PF13646.6 CRG88986.1 - 0.032 14.6 0.3 0.76 10.2 0.1 3.5 4 0 0 4 4 4 0 HEAT repeats HEAT PF02985.22 CRG88986.1 - 0.44 10.9 9.6 13 6.3 0.1 4.8 6 0 0 6 6 6 0 HEAT repeat Asp PF00026.23 CRG88988.1 - 9.7e-07 28.5 0.4 1.6e-06 27.8 0.4 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease DUF347 PF03988.12 CRG88988.1 - 0.019 15.2 0.1 0.055 13.7 0.1 1.8 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) SnoaL_4 PF13577.6 CRG88989.1 - 2.9e-20 72.7 0.1 3.3e-20 72.5 0.1 1.0 1 0 0 1 1 1 1 SnoaL-like domain Sugar_tr PF00083.24 CRG88990.1 - 6.5e-95 318.6 23.6 7.7e-95 318.4 23.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG88990.1 - 5.1e-23 81.6 30.9 4.6e-18 65.3 11.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG88990.1 - 1.2 7.3 10.3 3.4 5.8 2.6 2.5 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Pec_lyase_C PF00544.19 CRG88991.1 - 2.9e-44 151.2 14.0 5.1e-44 150.4 14.0 1.4 1 0 0 1 1 1 1 Pectate lyase SnoaL PF07366.12 CRG88991.1 - 0.0012 18.6 0.1 0.0043 16.9 0.0 2.0 3 0 0 3 3 3 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CRG88991.1 - 0.0041 17.7 0.0 0.012 16.2 0.0 1.8 1 0 0 1 1 1 1 SnoaL-like domain MFS_1 PF07690.16 CRG88992.1 - 1e-30 106.9 25.7 1e-30 106.9 25.7 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG88992.1 - 8e-13 48.0 11.7 8e-13 48.0 11.7 2.7 1 1 1 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG88992.1 - 5.1e-08 31.8 3.6 9.1e-08 31.0 3.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) adh_short_C2 PF13561.6 CRG88993.1 - 4e-52 177.1 0.0 8e-52 176.1 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG88993.1 - 5.9e-41 140.1 0.0 8.7e-41 139.5 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase FAD_binding_4 PF01565.23 CRG88993.1 - 1e-30 106.3 0.7 2.3e-30 105.2 0.2 1.9 2 0 0 2 2 2 1 FAD binding domain KR PF08659.10 CRG88993.1 - 1.7e-11 44.4 0.0 3e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 KR domain BBE PF08031.12 CRG88993.1 - 0.00031 20.8 0.1 0.00091 19.3 0.1 1.8 1 0 0 1 1 1 1 Berberine and berberine like AAA_lid_3 PF17862.1 CRG88993.1 - 0.072 12.9 0.0 0.47 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA+ lid domain Epimerase PF01370.21 CRG88993.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 CRG88994.1 - 9.5e-06 24.8 0.1 1.8e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M24 PF00557.24 CRG88995.1 - 5e-24 85.2 0.0 6.7e-24 84.8 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 CRG88995.1 - 2.1e-06 28.4 0.1 2.1e-06 28.4 0.1 2.1 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain TPR_1 PF00515.28 CRG88997.1 - 2e-50 166.6 27.2 5.3e-08 32.4 0.1 11.4 10 2 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 CRG88997.1 - 8.9e-46 150.3 18.7 1.9e-05 24.4 0.0 11.0 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 CRG88997.1 - 1.2e-34 115.6 17.6 6.7e-05 22.8 0.0 10.9 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_17 PF13431.6 CRG88997.1 - 1.2e-25 88.0 17.3 0.00039 20.6 0.1 9.8 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 CRG88997.1 - 4.5e-25 87.9 15.6 0.00011 22.7 0.1 7.4 4 2 3 7 7 7 7 Tetratricopeptide repeat TPR_14 PF13428.6 CRG88997.1 - 4.8e-25 86.1 17.9 5.9e-05 23.6 0.1 9.3 4 3 7 11 11 10 8 Tetratricopeptide repeat TPR_11 PF13414.6 CRG88997.1 - 6.8e-25 86.5 28.6 3.4e-06 26.7 0.2 10.0 6 3 4 10 10 10 6 TPR repeat TPR_16 PF13432.6 CRG88997.1 - 4.6e-23 81.6 15.4 5.1e-05 23.8 0.1 7.3 5 2 3 8 8 7 6 Tetratricopeptide repeat TPR_12 PF13424.6 CRG88997.1 - 6.8e-22 77.6 21.0 3.7e-05 23.9 0.8 8.1 3 2 4 7 7 7 4 Tetratricopeptide repeat TPR_6 PF13174.6 CRG88997.1 - 2.1e-20 72.0 17.7 0.0017 18.9 0.0 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 CRG88997.1 - 2.8e-19 67.7 16.8 0.0092 15.9 0.1 9.9 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_9 PF13371.6 CRG88997.1 - 3.4e-17 62.3 12.4 0.00062 19.9 0.5 7.2 2 2 6 8 8 8 6 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG88997.1 - 6.4e-15 55.1 8.0 9.6e-09 35.4 1.8 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 CRG88997.1 - 2.1e-08 33.7 9.0 0.0084 15.4 2.5 5.7 1 1 2 4 4 4 2 Tetratricopeptide repeat TPR_21 PF09976.9 CRG88997.1 - 2.2e-06 27.5 5.5 0.024 14.3 0.0 4.5 3 2 1 5 5 5 2 Tetratricopeptide repeat-like domain BTAD PF03704.17 CRG88997.1 - 9.4e-06 26.1 5.9 0.034 14.6 0.1 3.5 3 0 0 3 3 3 1 Bacterial transcriptional activator domain TPR_MalT PF17874.1 CRG88997.1 - 0.00092 18.7 6.1 0.098 12.0 1.9 3.8 1 1 2 3 3 3 2 MalT-like TPR region DUF2225 PF09986.9 CRG88997.1 - 0.0066 16.2 5.7 2.7 7.7 0.0 3.1 3 1 0 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 CRG88997.1 - 0.058 13.7 5.3 0.64 10.4 0.0 4.3 3 1 2 5 5 5 0 Tetratricopeptide repeat DUF3759 PF12585.8 CRG88998.1 - 2.4e-37 126.9 3.9 2.6e-37 126.7 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Phe_ZIP PF08916.11 CRG88998.1 - 0.1 13.3 0.3 0.21 12.3 0.3 1.5 1 0 0 1 1 1 0 Phenylalanine zipper GFO_IDH_MocA PF01408.22 CRG88999.1 - 1e-18 68.3 0.1 2.8e-18 66.9 0.1 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold MFS_1 PF07690.16 CRG88999.1 - 1.2e-11 44.2 6.7 1.2e-11 44.2 6.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG88999.1 - 0.0007 18.1 0.1 0.0012 17.4 0.1 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) GFO_IDH_MocA_C PF02894.17 CRG88999.1 - 0.0065 16.5 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain SKN1 PF03935.15 CRG89002.1 - 1.1e-225 749.8 0.6 1.5e-225 749.4 0.6 1.2 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Acetyltransf_1 PF00583.25 CRG89003.1 - 1.8e-07 31.4 0.0 3e-07 30.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG89003.1 - 4.1e-07 30.0 0.0 6.9e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG89003.1 - 0.00016 22.0 0.0 0.0003 21.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG89003.1 - 0.002 18.2 0.0 0.0039 17.3 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 CRG89003.1 - 0.0041 17.1 0.0 0.0071 16.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 CRG89003.1 - 0.0064 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Sensor_TM1 PF13755.6 CRG89004.1 - 0.029 14.1 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain Sugar_tr PF00083.24 CRG89005.1 - 1e-92 311.4 27.8 1.3e-92 311.0 27.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89005.1 - 1.1e-15 57.4 47.0 2.3e-13 49.8 17.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BCDHK_Adom3 PF10436.9 CRG89007.1 - 6.9e-74 247.1 0.0 1e-73 246.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 CRG89007.1 - 8.1e-13 48.9 0.0 1.6e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 CRG89007.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase His_Phos_1 PF00300.22 CRG89008.1 - 2e-25 89.6 0.1 3e-25 89.1 0.1 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) 6PF2K PF01591.18 CRG89009.1 - 3e-77 258.9 0.0 5.3e-77 258.1 0.0 1.4 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 CRG89009.1 - 1.8e-39 135.5 0.0 3.2e-39 134.6 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RRM_1 PF00076.22 CRG89009.1 - 6.5e-20 70.7 0.2 4.4e-15 55.3 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KTI12 PF08433.10 CRG89009.1 - 1.8e-05 24.3 0.0 3e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 CRG89009.1 - 0.0014 18.8 0.0 0.0073 16.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain Limkain-b1 PF11608.8 CRG89009.1 - 0.087 12.9 0.0 5.8 7.1 0.0 2.5 2 0 0 2 2 2 0 Limkain b1 Vps39_1 PF10366.9 CRG89010.1 - 3.2e-32 111.0 0.0 5.7e-31 107.0 0.0 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 CRG89010.1 - 7.6e-25 87.5 0.1 2.8e-24 85.7 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 CRG89010.1 - 2.3e-17 63.5 0.0 1e-16 61.4 0.0 2.0 1 1 0 1 1 1 1 CNH domain Clathrin PF00637.20 CRG89010.1 - 6.2e-09 35.9 2.3 1e-07 31.9 1.4 2.5 2 0 0 2 2 2 1 Region in Clathrin and VPS CPSF_A PF03178.15 CRG89010.1 - 0.064 12.6 0.0 9.3 5.5 0.0 2.4 1 1 0 2 2 2 0 CPSF A subunit region PPR PF01535.20 CRG89010.1 - 0.17 12.2 0.1 34 5.0 0.0 3.8 3 0 0 3 3 3 0 PPR repeat Gon7 PF08738.10 CRG89011.1 - 3.8e-12 46.2 1.1 5.4e-12 45.7 0.5 1.5 1 1 1 2 2 2 1 Gon7 family HbrB PF08539.11 CRG89012.1 - 9.7e-49 165.6 0.7 3e-48 164.0 0.0 2.3 2 0 0 2 2 2 1 HbrB-like TFIIA PF03153.13 CRG89012.1 - 3.3 7.6 35.6 0.39 10.7 28.2 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit HSP70 PF00012.20 CRG89013.1 - 1.1e-07 30.4 0.0 1.6e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein StbA PF06406.11 CRG89013.1 - 0.056 12.7 0.0 4 6.6 0.0 2.2 2 0 0 2 2 2 0 StbA protein Peptidase_S9 PF00326.21 CRG89014.1 - 2e-32 112.4 0.0 3.1e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family PD40 PF07676.12 CRG89014.1 - 3.1e-13 49.3 4.7 2.3e-07 30.6 0.1 4.6 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat DLH PF01738.18 CRG89014.1 - 0.00027 20.6 0.0 0.00066 19.3 0.0 1.6 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 CRG89014.1 - 0.00038 20.4 0.0 0.0035 17.2 0.0 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG89014.1 - 0.00056 20.6 2.3 0.00056 20.6 2.3 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG89014.1 - 0.003 16.9 0.0 0.11 11.8 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DPPIV_N PF00930.21 CRG89014.1 - 0.0037 16.1 0.0 6.2 5.5 0.0 3.2 2 1 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Abhydrolase_1 PF00561.20 CRG89014.1 - 0.02 14.5 0.2 0.059 13.0 0.3 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold WD40 PF00400.32 CRG89014.1 - 0.035 15.0 2.5 2.9 8.9 0.1 4.2 3 1 0 3 3 3 0 WD domain, G-beta repeat AXE1 PF05448.12 CRG89014.1 - 0.14 10.8 0.0 0.26 9.9 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) AAA PF00004.29 CRG89015.1 - 1.2e-16 61.3 0.0 4.5e-16 59.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CRG89015.1 - 0.00027 20.9 0.0 0.0011 19.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CRG89015.1 - 0.0013 19.0 0.6 0.012 15.8 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 CRG89015.1 - 0.015 15.7 0.1 0.015 15.7 0.1 2.4 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 CRG89015.1 - 0.018 15.4 0.2 0.018 15.4 0.2 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_11 PF13086.6 CRG89015.1 - 0.039 13.7 0.0 0.039 13.7 0.0 3.7 3 1 1 4 4 4 0 AAA domain Hamartin PF04388.12 CRG89015.1 - 0.22 10.1 33.7 0.33 9.6 33.7 1.2 1 0 0 1 1 1 0 Hamartin protein Abhydrolase_4 PF08386.10 CRG89016.1 - 2e-20 72.8 0.2 5.5e-20 71.4 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_1 PF00561.20 CRG89016.1 - 3.5e-17 62.9 0.0 5.8e-15 55.6 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG89016.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ldh_1_C PF02866.18 CRG89017.1 - 6.9e-47 159.5 0.0 2e-46 158.0 0.0 1.7 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 CRG89017.1 - 1.5e-43 148.3 0.1 2.9e-43 147.4 0.0 1.5 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CRG89017.1 - 0.0013 17.8 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family THF_DHG_CYH_C PF02882.19 CRG89017.1 - 0.07 12.4 0.0 0.97 8.7 0.0 2.6 2 1 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF5353 PF17304.2 CRG89018.1 - 9.9e-26 89.3 3.9 9.9e-26 89.3 3.9 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5353) V-SNARE_C PF12352.8 CRG89018.1 - 1.8e-12 47.4 0.4 5.3e-12 45.8 0.4 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 CRG89018.1 - 0.0089 15.9 0.0 0.036 14.0 0.0 2.0 2 0 0 2 2 2 1 Sec20 DUF4203 PF13886.6 CRG89018.1 - 0.018 14.7 0.3 0.065 12.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) CbtA PF09490.10 CRG89018.1 - 0.16 11.7 3.0 0.31 10.8 3.0 1.4 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) WXG100 PF06013.12 CRG89018.1 - 0.33 11.2 3.0 0.46 10.8 0.4 2.6 3 0 0 3 3 3 0 Proteins of 100 residues with WXG DUF4337 PF14235.6 CRG89018.1 - 1.4 9.1 7.4 2.6 8.1 0.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4337) CCDC-167 PF15188.6 CRG89018.1 - 2.6 8.5 6.2 0.87 10.0 0.5 2.8 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 ATP-synt_B PF00430.18 CRG89018.1 - 6.9 6.8 16.6 1.5 8.9 6.4 2.4 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) Pribosyltran_N PF13793.6 CRG89019.1 - 2.5e-43 146.7 0.1 1.2e-42 144.5 0.0 2.2 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CRG89019.1 - 2.3e-34 119.0 0.1 1.2e-29 103.6 0.1 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CRG89019.1 - 1.7e-07 30.9 0.0 9.6e-05 21.9 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosyl transferase domain Sirohm_synth_C PF14823.6 CRG89020.1 - 2.3e-32 110.5 0.1 3.5e-32 109.9 0.1 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 CRG89020.1 - 1.2e-31 109.2 0.0 2.4e-31 108.3 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 CRG89020.1 - 2.6e-14 52.4 0.0 2.6e-14 52.4 0.0 1.5 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 CRG89020.1 - 0.012 14.9 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CRG89020.1 - 0.016 15.5 0.1 0.029 14.6 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 CRG89020.1 - 0.055 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 CRG89020.1 - 0.063 12.6 0.2 0.15 11.4 0.0 1.6 1 1 1 2 2 2 0 ThiF family LSDAT_prok PF18171.1 CRG89020.1 - 0.089 12.0 0.1 0.15 11.3 0.1 1.3 1 0 0 1 1 1 0 SLOG in TRPM, prokaryote Sec7 PF01369.20 CRG89021.1 - 3.2e-71 238.8 0.6 1.1e-70 237.1 0.6 2.0 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 CRG89021.1 - 5e-42 143.5 12.9 5.4e-42 143.4 7.0 3.5 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 CRG89021.1 - 1.8e-33 114.2 8.9 1.7e-31 107.9 0.1 5.8 5 0 0 5 5 5 2 Domain of unknown function (DUF1981) DCB PF16213.5 CRG89021.1 - 2.4e-17 63.2 4.1 1.9e-16 60.3 0.8 3.3 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 2-oxoacid_dh PF00198.23 CRG89022.1 - 2.4e-78 262.8 0.1 4.1e-78 262.0 0.1 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 CRG89022.1 - 8.3e-17 60.8 0.4 8.3e-17 60.8 0.4 2.1 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 CRG89022.1 - 6.7e-13 48.7 0.3 2.6e-12 46.8 0.3 2.1 1 0 0 1 1 1 1 e3 binding domain PLDc_2 PF13091.6 CRG89024.1 - 7.7e-17 61.4 0.1 1.6e-06 28.1 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain PLDc PF00614.22 CRG89024.1 - 1.7e-13 50.1 4.0 1.8e-07 31.0 0.3 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif Methyltransf_10 PF05971.12 CRG89025.1 - 1.7e-63 214.8 0.0 2.3e-63 214.3 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 CRG89025.1 - 2.8e-05 23.8 0.0 5.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain TIMELESS PF04821.14 CRG89026.1 - 0.0083 15.4 0.3 0.011 15.1 0.3 1.1 1 0 0 1 1 1 1 Timeless protein ABC_tran PF00005.27 CRG89027.1 - 2.9e-47 160.6 0.1 6.2e-24 85.1 0.0 4.3 2 2 0 2 2 2 2 ABC transporter 4HB PF17947.1 CRG89027.1 - 2.2e-28 98.1 0.4 6.2e-28 96.7 0.4 1.8 1 0 0 1 1 1 1 Four helical bundle domain SMC_N PF02463.19 CRG89027.1 - 1.3e-15 57.5 0.0 6.3e-06 25.8 0.0 3.6 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG89027.1 - 6.8e-15 55.7 1.1 0.0026 17.6 0.1 4.6 4 1 0 5 5 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG89027.1 - 6.9e-09 35.3 0.1 0.0041 16.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG89027.1 - 1.4e-08 35.5 8.4 0.00023 21.8 0.1 3.6 4 0 0 4 4 3 2 AAA domain RsgA_GTPase PF03193.16 CRG89027.1 - 3.7e-07 30.2 0.0 0.0021 18.0 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 CRG89027.1 - 1.2e-06 28.5 0.0 0.0056 16.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 CRG89027.1 - 1.4e-06 28.7 0.0 0.017 15.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 CRG89027.1 - 4.5e-06 27.0 0.0 0.079 13.2 0.0 3.5 4 0 0 4 4 2 2 AAA domain AAA_16 PF13191.6 CRG89027.1 - 4.5e-06 27.2 0.9 0.18 12.2 0.0 4.1 5 1 0 5 5 3 2 AAA ATPase domain AAA PF00004.29 CRG89027.1 - 1.4e-05 25.6 0.0 0.53 10.7 0.0 4.4 6 0 0 6 6 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 CRG89027.1 - 1.8e-05 25.3 0.1 0.19 12.3 0.0 3.0 2 0 0 2 2 2 2 AAA domain Dynamin_N PF00350.23 CRG89027.1 - 4e-05 23.7 0.1 0.0018 18.4 0.0 2.9 2 1 0 2 2 2 1 Dynamin family PduV-EutP PF10662.9 CRG89027.1 - 6e-05 22.8 0.0 0.077 12.7 0.0 2.7 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 CRG89027.1 - 9.1e-05 22.4 0.0 0.089 12.7 0.0 2.9 2 0 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 CRG89027.1 - 0.00014 22.0 0.1 0.49 10.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 CRG89027.1 - 0.00016 22.0 0.0 0.7 10.3 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_15 PF13175.6 CRG89027.1 - 0.00022 21.1 1.6 0.85 9.3 0.0 3.4 3 1 0 3 3 3 2 AAA ATPase domain AAA_27 PF13514.6 CRG89027.1 - 0.00034 20.3 0.0 0.3 10.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 CRG89027.1 - 0.00037 20.7 3.9 0.15 12.1 0.0 3.4 4 0 0 4 4 2 2 Helicase HerA, central domain MeaB PF03308.16 CRG89027.1 - 0.00044 19.3 0.2 0.72 8.8 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 CRG89027.1 - 0.00048 19.9 0.0 2.4 7.8 0.0 3.3 3 0 0 3 3 3 2 AAA domain G-alpha PF00503.20 CRG89027.1 - 0.00082 18.6 0.0 1.8 7.6 0.0 3.0 3 0 0 3 3 3 2 G-protein alpha subunit AAA_24 PF13479.6 CRG89027.1 - 0.0012 18.6 0.0 1.3 8.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 CRG89027.1 - 0.0014 18.7 0.0 4.1 7.5 0.0 3.1 3 0 0 3 3 2 0 AAA domain SbcCD_C PF13558.6 CRG89027.1 - 0.0037 17.5 0.0 1.1 9.5 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 CRG89027.1 - 0.0071 15.6 0.1 0.26 10.5 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain ATP_bind_1 PF03029.17 CRG89027.1 - 0.0077 16.0 0.0 3.7 7.3 0.0 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein cobW PF02492.19 CRG89027.1 - 0.0083 15.7 0.1 8 6.0 0.0 3.2 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain HEAT_2 PF13646.6 CRG89027.1 - 0.011 16.1 1.8 7 7.1 0.7 3.6 2 1 2 4 4 4 0 HEAT repeats Roc PF08477.13 CRG89027.1 - 0.014 15.6 0.0 8.2 6.7 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 CRG89027.1 - 0.021 14.8 0.1 3 7.7 0.0 3.0 3 0 0 3 3 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 CRG89027.1 - 0.022 14.5 0.0 13 5.5 0.0 2.9 2 0 0 2 2 2 0 IstB-like ATP binding protein Rad17 PF03215.15 CRG89027.1 - 0.022 14.7 0.0 1.2 9.0 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 CRG89027.1 - 0.023 14.2 0.0 5 6.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Cytidylate_kin PF02224.18 CRG89027.1 - 0.029 14.1 0.0 5.6 6.6 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase Mg_chelatase PF01078.21 CRG89027.1 - 0.039 13.3 0.4 3.3 7.0 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CRG89027.1 - 0.041 13.9 0.0 19 5.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) CLP1_P PF16575.5 CRG89027.1 - 0.046 13.5 1.8 1.4 8.6 0.0 3.0 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MukB PF04310.12 CRG89027.1 - 0.056 13.2 0.0 9.7 5.9 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal Ploopntkinase3 PF18751.1 CRG89027.1 - 0.07 13.0 0.0 11 5.8 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 ATP-synt_ab PF00006.25 CRG89027.1 - 0.075 12.7 0.1 11 5.6 0.0 2.6 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain HEAT PF02985.22 CRG89027.1 - 0.079 13.3 0.0 17 6.0 0.0 3.5 3 0 0 3 3 2 0 HEAT repeat DUF815 PF05673.13 CRG89027.1 - 0.084 12.0 0.0 11 5.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 CRG89027.1 - 0.092 12.3 0.0 5.1 6.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 CRG89027.1 - 0.79 8.3 5.8 3.1 6.3 0.0 3.1 5 0 0 5 5 4 0 AAA domain Ank_4 PF13637.6 CRG89029.1 - 4.8e-13 49.3 0.4 7.1e-10 39.2 0.1 3.8 2 1 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG89029.1 - 8.3e-07 29.5 0.3 0.018 15.6 0.1 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG89029.1 - 4.6e-06 26.6 0.5 0.0039 17.6 0.1 4.1 4 1 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 CRG89029.1 - 4.7e-05 23.6 0.2 0.0065 16.8 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) KilA-N PF04383.13 CRG89029.1 - 0.0017 18.2 0.2 0.011 15.6 0.2 2.2 1 1 0 1 1 1 1 KilA-N domain Ank PF00023.30 CRG89029.1 - 0.012 16.0 1.8 0.32 11.5 0.1 3.3 3 0 0 3 3 3 0 Ankyrin repeat TPR_11 PF13414.6 CRG89030.1 - 1e-07 31.5 0.5 0.0031 17.2 0.1 3.0 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 CRG89030.1 - 4.1e-07 29.9 2.8 0.0014 18.9 0.1 3.7 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 CRG89030.1 - 4.2e-07 29.5 8.3 0.006 16.4 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG89030.1 - 4.9e-07 30.2 5.9 0.0012 19.3 0.5 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89030.1 - 1.6e-05 24.6 12.1 0.004 17.1 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG89030.1 - 1.7e-05 24.7 0.5 4.8 7.7 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 CRG89030.1 - 3.6e-05 24.3 4.2 0.0019 18.8 1.2 4.3 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG89030.1 - 0.0028 17.8 3.9 0.049 13.8 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG89030.1 - 0.0052 16.7 1.9 0.13 12.3 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89030.1 - 0.011 16.0 4.9 0.99 9.7 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG89030.1 - 0.12 13.3 0.1 0.12 13.3 0.1 4.9 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CRG89030.1 - 0.39 11.5 3.3 17 6.3 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Sugar_tr PF00083.24 CRG89031.1 - 2e-89 300.6 23.4 2.2e-89 300.4 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89031.1 - 1e-23 83.9 29.3 1e-23 83.9 29.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG89031.1 - 4e-05 23.1 1.8 4e-05 23.1 1.8 1.7 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF1751 PF08551.10 CRG89032.1 - 0.041 14.5 1.5 1.8 9.2 0.2 2.6 1 1 1 2 2 2 0 Eukaryotic integral membrane protein (DUF1751) TauD PF02668.16 CRG89033.1 - 3.7e-38 131.9 0.0 5.2e-38 131.4 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family NAD_binding_10 PF13460.6 CRG89034.1 - 9.3e-07 28.9 0.0 8.7e-06 25.7 0.0 2.3 1 1 0 1 1 1 1 NAD(P)H-binding AAA PF00004.29 CRG89035.1 - 7.8e-12 45.8 0.0 1.6e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG89035.1 - 5.5e-07 29.9 0.0 1.4e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 CRG89035.1 - 0.00013 22.0 0.0 0.00069 19.6 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 CRG89035.1 - 0.00022 21.0 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 CRG89035.1 - 0.00034 20.6 0.0 0.0011 19.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CRG89035.1 - 0.0009 19.4 0.0 0.0022 18.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG89035.1 - 0.0022 18.4 0.0 0.016 15.6 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CRG89035.1 - 0.005 16.9 0.0 0.0099 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CRG89035.1 - 0.0055 16.1 0.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 CRG89035.1 - 0.022 14.5 0.1 0.047 13.4 0.1 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 CRG89035.1 - 0.044 13.7 0.0 0.099 12.5 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_24 PF13479.6 CRG89035.1 - 0.073 12.8 0.0 0.16 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CRG89035.1 - 0.1 13.2 0.0 0.27 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain SWIRM PF04433.17 CRG89036.1 - 6.1e-32 109.8 0.0 1.6e-31 108.5 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 CRG89036.1 - 3.9e-31 106.8 12.4 3.9e-31 106.8 12.4 2.0 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 CRG89036.1 - 2.9e-09 36.9 0.1 1.1e-08 35.1 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG89036.1 - 6.5e-08 32.7 0.1 1.8e-07 31.3 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 CRG89036.1 - 0.064 13.2 1.6 0.58 10.1 0.0 2.7 2 0 0 2 2 2 0 Myb DNA-binding like AAA_9 PF12781.7 CRG89036.1 - 0.15 11.2 1.7 0.27 10.4 1.7 1.3 1 0 0 1 1 1 0 ATP-binding dynein motor region Myb_DNA-binding PF00249.31 CRG89037.1 - 0.081 13.1 0.1 0.26 11.5 0.1 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain ResIII PF04851.15 CRG89038.1 - 8.1e-25 87.8 0.3 6.2e-24 84.9 0.0 2.6 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 CRG89038.1 - 1.5e-15 57.4 0.0 6.5e-11 42.3 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG89038.1 - 1e-12 48.3 0.7 3.8e-12 46.5 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 CRG89038.1 - 7.8e-05 22.5 0.3 0.0002 21.1 0.0 1.8 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 CRG89038.1 - 0.0047 16.2 0.0 0.0092 15.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Sugar_tr PF00083.24 CRG89039.1 - 8.2e-39 133.7 22.2 1.1e-37 130.0 22.2 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89039.1 - 2.5e-32 112.2 44.6 2.9e-29 102.1 28.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GMC_oxred_N PF00732.19 CRG89040.1 - 4.6e-50 170.7 0.0 6.2e-50 170.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG89040.1 - 7.9e-32 110.8 0.0 1.3e-31 110.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Catalase-rel PF06628.12 CRG89040.1 - 6.6e-09 35.9 0.0 1.2e-08 35.0 0.0 1.4 1 0 0 1 1 1 1 Catalase-related immune-responsive FAD_binding_2 PF00890.24 CRG89040.1 - 9.1e-06 25.0 0.3 0.02 14.0 0.3 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CRG89040.1 - 1.6e-05 24.7 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG89040.1 - 0.00024 20.4 0.8 0.00037 19.8 0.1 1.6 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 CRG89040.1 - 0.0013 18.9 0.0 0.0035 17.5 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG89040.1 - 0.014 14.5 0.0 0.026 13.6 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG89040.1 - 0.018 14.3 0.4 1.4 8.1 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG89040.1 - 0.033 13.4 0.0 0.11 11.8 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG89040.1 - 0.18 10.6 0.2 0.27 10.0 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Dyp_perox PF04261.12 CRG89041.1 - 5.1e-90 301.8 0.0 5.9e-90 301.6 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family PGAP1 PF07819.13 CRG89042.1 - 1.3e-88 296.6 0.0 2.7e-88 295.6 0.0 1.6 1 0 0 1 1 1 1 PGAP1-like protein Fungal_trans_2 PF11951.8 CRG89042.1 - 7.3e-14 51.4 0.1 1.3e-13 50.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Abhydrolase_6 PF12697.7 CRG89042.1 - 1e-05 26.3 0.2 3.5e-05 24.5 0.2 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG89042.1 - 0.00016 21.4 0.3 0.00054 19.7 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Palm_thioest PF02089.15 CRG89042.1 - 0.00053 19.9 0.0 0.00088 19.2 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Hydrolase_4 PF12146.8 CRG89042.1 - 0.0035 16.6 0.0 0.0067 15.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF676 PF05057.14 CRG89042.1 - 0.0072 15.9 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LCAT PF02450.15 CRG89042.1 - 0.0091 15.2 0.0 0.017 14.3 0.0 1.3 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Esterase PF00756.20 CRG89042.1 - 0.022 14.4 0.1 0.055 13.1 0.1 1.6 1 0 0 1 1 1 0 Putative esterase Abhydrolase_3 PF07859.13 CRG89042.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Lipase_3 PF01764.25 CRG89042.1 - 0.13 12.1 0.0 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 Lipase (class 3) BPS1 PF05633.11 CRG89043.1 - 0.0048 16.0 2.2 0.0051 15.9 2.2 1.0 1 0 0 1 1 1 1 Protein BYPASS1-related SR-25 PF10500.9 CRG89043.1 - 0.39 10.3 11.7 0.47 10.0 11.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein adh_short_C2 PF13561.6 CRG89044.1 - 2.4e-32 112.4 0.0 3.1e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89044.1 - 3.5e-26 91.9 0.0 4.8e-26 91.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89044.1 - 1.9e-08 34.5 0.0 3.3e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG89044.1 - 0.012 14.7 0.1 0.018 14.2 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 CRG89044.1 - 0.032 14.0 0.2 0.082 12.7 0.2 1.7 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Ferritin_2 PF13668.6 CRG89045.1 - 5.5e-10 39.6 0.2 9.1e-10 38.9 0.2 1.4 1 0 0 1 1 1 1 Ferritin-like domain Fungal_trans_2 PF11951.8 CRG89046.1 - 2.4e-07 29.9 0.7 5.5e-07 28.7 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain CBM_21 PF03370.13 CRG89047.1 - 2.8e-35 120.9 0.5 4.6e-35 120.2 0.5 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 CRG89047.1 - 4.1e-09 36.9 1.5 8e-09 36.0 1.5 1.4 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) CENP-T_C PF15511.6 CRG89047.1 - 8.3e-08 32.3 0.3 2.8e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 CRG89047.1 - 9.3e-05 22.8 1.3 0.00088 19.6 0.1 2.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 CRG89047.1 - 0.0011 19.1 0.1 0.0026 17.9 0.1 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 CRG89047.1 - 0.0031 17.8 0.0 0.0076 16.5 0.0 1.7 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 CRG89047.1 - 0.004 17.5 0.0 0.0083 16.5 0.0 1.5 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CRG89047.1 - 0.066 13.3 0.0 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CRG89047.1 - 0.076 13.0 0.0 0.21 11.7 0.0 1.6 2 0 0 2 2 2 0 Bromodomain associated Asp PF00026.23 CRG89048.1 - 4.7e-35 121.5 2.6 5.7e-35 121.2 2.6 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG89048.1 - 1.5e-05 25.3 7.2 0.017 15.4 0.2 3.1 1 1 2 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG89048.1 - 2e-05 25.1 1.4 0.0084 16.7 0.3 3.3 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 CRG89048.1 - 0.0012 19.3 0.0 0.21 12.1 0.0 3.1 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease ADH_N PF08240.12 CRG89049.1 - 4.1e-21 74.9 0.2 8.9e-21 73.8 0.2 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89049.1 - 3.7e-10 39.9 0.0 6.5e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG89049.1 - 9.5e-05 21.8 0.0 0.00016 21.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CRG89049.1 - 0.025 13.9 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Mito_carr PF00153.27 CRG89050.1 - 3.7e-47 158.2 2.9 4.7e-15 55.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Phageshock_PspD PF09584.10 CRG89050.1 - 0.074 13.1 0.5 0.17 12.0 0.5 1.5 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) TPK_catalytic PF04263.16 CRG89052.1 - 4.5e-29 100.9 0.1 7.8e-28 96.9 0.1 2.6 2 1 0 2 2 2 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 CRG89052.1 - 7.4e-16 57.6 0.0 1.2e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Mito_carr PF00153.27 CRG89054.1 - 5.8e-59 196.0 5.2 4.8e-18 64.9 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein UPF0121 PF03661.13 CRG89055.1 - 6.4e-29 101.0 6.1 8.7e-29 100.6 6.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Septin PF00735.18 CRG89056.1 - 8.7e-122 405.8 0.1 8.7e-122 405.8 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 CRG89056.1 - 6.6e-09 35.9 0.0 2.1e-08 34.2 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG89056.1 - 2.4e-05 24.0 2.0 0.0022 17.6 0.0 2.9 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 CRG89056.1 - 0.00047 20.4 0.0 0.002 18.3 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 CRG89056.1 - 0.0011 19.5 4.1 0.015 15.8 0.0 2.7 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 CRG89056.1 - 0.0011 18.9 10.3 0.0013 18.7 0.7 3.4 3 1 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 CRG89056.1 - 0.0021 17.4 2.4 0.0026 17.1 0.0 2.2 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.6 CRG89056.1 - 0.0035 17.7 0.1 0.012 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CRG89056.1 - 0.0053 17.0 0.7 0.023 15.0 0.0 2.4 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CRG89056.1 - 0.009 15.7 0.0 0.019 14.7 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Ras PF00071.22 CRG89056.1 - 0.012 15.3 0.0 0.043 13.4 0.0 2.0 1 0 0 1 1 1 0 Ras family Exonuc_VII_L PF02601.15 CRG89056.1 - 0.047 13.2 3.8 0.088 12.4 3.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_24 PF13479.6 CRG89056.1 - 0.049 13.3 0.2 0.11 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 CRG89056.1 - 0.078 12.5 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region IIGP PF05049.13 CRG89056.1 - 0.092 11.8 0.2 0.092 11.8 0.2 2.2 2 1 0 2 2 2 0 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 CRG89056.1 - 0.1 13.0 0.7 1.1 9.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase ATP_bind_1 PF03029.17 CRG89056.1 - 0.16 11.8 4.8 0.62 9.8 0.0 3.0 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 CRG89056.1 - 0.44 10.6 0.1 0.44 10.6 0.1 3.5 2 2 0 3 3 2 0 Dynamin family DUF3987 PF13148.6 CRG89056.1 - 8.1 5.3 10.3 2.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) AAA_32 PF13654.6 CRG89056.1 - 8.8 5.0 16.8 2.9 6.6 0.0 2.5 3 0 0 3 3 3 0 AAA domain CHCH PF06747.13 CRG89057.1 - 3.1e-07 30.4 4.2 6.1e-07 29.4 4.2 1.5 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 CRG89057.1 - 0.037 14.5 2.2 0.098 13.1 2.2 1.7 1 0 0 1 1 1 0 GCK domain PepSY_TM PF03929.16 CRG89057.1 - 1.4 8.5 5.3 2 8.0 0.0 2.1 2 0 0 2 2 2 0 PepSY-associated TM region MIF4G PF02854.19 CRG89058.1 - 1e-56 191.9 0.0 3.6e-33 115.0 0.0 3.5 3 1 0 3 3 3 2 MIF4G domain Upf2 PF04050.14 CRG89058.1 - 2.5e-39 135.1 9.7 2.5e-39 135.1 9.7 2.6 2 0 0 2 2 2 1 Up-frameshift suppressor 2 DUF3176 PF11374.8 CRG89059.1 - 2.6e-17 63.0 1.3 6.7e-17 61.6 1.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) PAGK PF15284.6 CRG89059.1 - 0.23 11.4 3.0 7.1 6.6 0.6 2.6 2 0 0 2 2 2 0 Phage-encoded virulence factor p450 PF00067.22 CRG89060.1 - 1.2e-05 24.2 0.0 1.7e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Aldo_ket_red PF00248.21 CRG89061.1 - 1.8e-19 70.0 0.0 2e-19 69.9 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Fungal_trans PF04082.18 CRG89062.1 - 5.7e-14 51.8 0.6 3.6e-13 49.2 0.1 2.1 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89062.1 - 1.9e-07 31.1 11.3 3.4e-07 30.3 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG89063.1 - 5.4e-24 84.8 36.5 5.4e-23 81.5 36.5 2.6 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG89063.1 - 1.2e-08 33.9 11.0 2.7e-08 32.7 11.0 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Dicty_CAD PF05720.12 CRG89064.1 - 0.069 13.1 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Cell-cell adhesion domain SUN PF03856.13 CRG89065.1 - 1.7e-88 296.2 7.3 2.8e-88 295.5 7.3 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) SOG2 PF10428.9 CRG89065.1 - 0.12 11.6 15.2 0.15 11.2 15.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MGC-24 PF05283.11 CRG89065.1 - 0.58 10.6 18.3 1.6 9.2 18.3 1.8 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Ribosomal_L1 PF00687.21 CRG89067.1 - 4e-62 209.6 5.1 7.1e-62 208.8 5.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family ETF PF01012.21 CRG89068.1 - 1e-45 155.8 1.1 1.8e-45 155.0 1.1 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 CRG89068.1 - 1.7e-33 114.5 0.4 3.3e-33 113.5 0.4 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain DUF3176 PF11374.8 CRG89069.1 - 9.6e-15 54.7 0.5 2.7e-14 53.3 0.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3176) Endopep_inhib PF16800.5 CRG89069.1 - 0.27 11.2 6.4 0.43 10.5 4.7 2.2 2 1 0 2 2 2 0 IseA DL-endopeptidase inhibitor Ank_2 PF12796.7 CRG89070.1 - 6.4e-35 119.6 0.1 1.3e-11 44.9 0.2 3.6 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG89070.1 - 4.5e-20 71.7 0.1 1.3e-06 28.9 0.1 6.1 3 1 2 6 6 6 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG89070.1 - 4.8e-20 69.5 0.6 0.0022 18.3 0.0 8.1 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 CRG89070.1 - 7.3e-17 61.0 1.8 0.0016 18.8 0.2 7.3 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 CRG89070.1 - 1.2e-13 51.0 5.2 0.0068 16.7 0.0 7.0 3 1 4 7 7 7 4 Ankyrin repeats (many copies) PreAtp-grasp PF18604.1 CRG89070.1 - 0.11 12.1 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Pre ATP-grasp domain UBA PF00627.31 CRG89070.1 - 0.37 10.8 1.8 14 5.7 0.0 2.9 3 0 0 3 3 3 0 UBA/TS-N domain p450 PF00067.22 CRG89071.1 - 2e-63 214.7 0.1 1.8e-50 172.0 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 NEMP PF10225.9 CRG89071.1 - 0.14 11.8 0.0 0.24 11.1 0.0 1.2 1 0 0 1 1 1 0 NEMP family PEMT PF04191.13 CRG89072.1 - 0.052 14.0 1.0 0.052 14.0 1.0 2.3 3 0 0 3 3 3 0 Phospholipid methyltransferase NmrA PF05368.13 CRG89075.1 - 3.3e-34 118.5 0.0 5.4e-34 117.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG89075.1 - 7.7e-22 78.1 0.0 1.1e-21 77.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG89075.1 - 8.3e-05 22.2 0.1 0.00034 20.2 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG89075.1 - 0.0016 17.9 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase PAC2 PF09754.9 CRG89075.1 - 0.0039 17.2 0.0 0.0061 16.6 0.0 1.3 1 1 0 1 1 1 1 PAC2 family adh_short PF00106.25 CRG89075.1 - 0.0048 16.4 0.0 0.0082 15.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Nitro_FeMo-Co PF02579.17 CRG89075.1 - 0.018 15.4 0.3 0.27 11.6 0.0 2.7 3 0 0 3 3 3 0 Dinitrogenase iron-molybdenum cofactor SAND PF01342.21 CRG89075.1 - 0.12 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 SAND domain MFS_1 PF07690.16 CRG89076.1 - 4.5e-40 137.6 35.9 4.8e-39 134.3 17.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89076.1 - 7.9e-09 34.9 10.7 7.9e-09 34.9 10.7 2.2 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CRG89076.1 - 2e-05 23.2 5.3 4e-05 22.2 5.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1129 PF06570.11 CRG89076.1 - 0.14 11.6 0.7 1 8.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Corona_S2 PF01601.16 CRG89076.1 - 0.66 8.4 2.1 1.2 7.5 2.1 1.4 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein EHN PF06441.12 CRG89077.1 - 3.9e-26 91.5 0.2 7.6e-26 90.6 0.2 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG89077.1 - 2.2e-11 43.9 0.1 3.7e-11 43.2 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG89077.1 - 0.11 13.1 2.7 0.21 12.2 2.7 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family MFS_1 PF07690.16 CRG89078.1 - 1.5e-39 136.0 64.3 2.3e-28 99.2 34.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89078.1 - 0.00091 18.2 31.6 0.068 12.0 10.6 2.2 1 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG89079.1 - 3e-35 121.8 77.8 2.9e-31 108.7 49.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Abhydrolase_6 PF12697.7 CRG89080.1 - 1e-13 52.4 0.0 1.8e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG89080.1 - 6.6e-12 45.6 0.0 7e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Fungal_trans PF04082.18 CRG89081.1 - 0.00078 18.5 0.1 0.0018 17.4 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain CMD PF02627.20 CRG89082.1 - 3.3e-18 65.5 0.0 6e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family ADH_zinc_N PF00107.26 CRG89082.1 - 3.5e-11 43.2 0.1 6.1e-11 42.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CRG89082.1 - 3.9e-05 23.0 0.1 7.4e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain PrmA PF06325.13 CRG89082.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Aldedh PF00171.22 CRG89083.1 - 1.1e-155 518.7 0.2 1.2e-155 518.5 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ADH_N PF08240.12 CRG89084.1 - 4.8e-07 29.6 0.0 5.6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NAD_binding_2 PF03446.15 CRG89085.1 - 1.1e-33 116.6 0.0 1.5e-33 116.2 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG89085.1 - 2.4e-21 76.2 0.0 3.6e-21 75.6 0.0 1.2 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 CRG89085.1 - 0.002 18.6 0.0 0.017 15.7 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 CRG89085.1 - 0.094 11.6 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Sacchrp_dh_NADP PF03435.18 CRG89085.1 - 0.15 12.3 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Sugar_tr PF00083.24 CRG89086.1 - 8.9e-85 285.2 27.7 1e-84 285.0 27.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89086.1 - 1.5e-20 73.5 57.4 1.9e-16 60.0 26.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Glyco_hydro_18 PF00704.28 CRG89087.1 - 1.7e-67 228.4 1.7 2e-67 228.2 1.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Zn_clus PF00172.18 CRG89088.1 - 2.4e-09 37.1 9.3 4.2e-09 36.4 9.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG89088.1 - 1.2e-06 27.7 0.1 2.1e-06 27.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain 4HBT_3 PF13622.6 CRG89089.1 - 9.3e-47 160.4 0.1 1.1e-46 160.1 0.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CRG89089.1 - 0.0013 18.5 0.1 0.0027 17.6 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA thioesterase Mannosidase_ig PF17786.1 CRG89090.1 - 3.7e-16 59.5 0.0 1.6e-15 57.5 0.0 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CRG89090.1 - 3.7e-12 46.9 0.0 8.5e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_N PF02837.18 CRG89090.1 - 0.0089 15.9 0.0 0.033 14.1 0.0 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, sugar binding domain Sugar_tr PF00083.24 CRG89092.1 - 2.7e-71 240.8 29.6 3.1e-71 240.6 29.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89092.1 - 1.8e-28 99.5 70.1 7.4e-25 87.6 44.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Cellulase PF00150.18 CRG89093.1 - 3.1e-17 62.9 0.1 4.1e-17 62.5 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 CRG89093.1 - 0.0059 15.8 0.1 0.011 14.9 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Transp_inhibit PF18791.1 CRG89093.1 - 0.11 12.0 0.5 0.32 10.5 0.2 2.0 2 0 0 2 2 2 0 Transport inhibitor response 1 protein domain Glyco_hydro_42 PF02449.15 CRG89093.1 - 0.12 11.7 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 Beta-galactosidase AP_endonuc_2 PF01261.24 CRG89093.1 - 0.17 11.3 0.0 0.37 10.2 0.0 1.7 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Fungal_trans PF04082.18 CRG89094.1 - 1.9e-14 53.3 0.0 3.6e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89094.1 - 4.1e-07 30.0 8.4 8.2e-07 29.1 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 CRG89095.1 - 2.4e-07 30.7 8.8 2.4e-07 30.7 8.8 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG89095.1 - 0.0094 15.0 0.5 0.032 13.2 0.1 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain ABC_tran_CTD PF16326.5 CRG89095.1 - 0.16 12.2 0.1 0.35 11.2 0.1 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain Sugar_tr PF00083.24 CRG89096.1 - 1e-83 281.7 18.7 1.2e-83 281.5 18.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89096.1 - 7.2e-24 84.4 30.8 9.4e-18 64.2 11.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG89096.1 - 0.00034 19.3 22.1 0.0064 15.1 5.3 2.8 3 0 0 3 3 3 2 MFS/sugar transport protein CVNH PF08881.10 CRG89097.1 - 3.8e-16 59.6 0.1 7.1e-16 58.7 0.1 1.5 1 0 0 1 1 1 1 CVNH domain Peptidase_C12 PF01088.21 CRG89098.1 - 1.2e-49 169.0 0.0 1.3e-49 168.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Zn_clus PF00172.18 CRG89099.1 - 7.3e-09 35.6 10.2 1.1e-08 35.1 10.2 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG89099.1 - 7.3e-06 25.0 2.2 1e-05 24.5 2.2 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Asp5 PF17000.5 CRG89100.1 - 0.37 10.9 1.8 19 5.5 0.1 2.2 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 UCR_Fe-S_N PF10399.9 CRG89101.1 - 0.24 10.8 1.6 0.27 10.6 0.4 1.8 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DUF3188 PF11384.8 CRG89101.1 - 1.1 9.0 3.9 2.2 8.0 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) CVNH PF08881.10 CRG89102.1 - 1.2e-11 45.1 0.0 2.9e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 CVNH domain Rick_17kDa_Anti PF05433.15 CRG89102.1 - 7.9e-06 25.6 13.7 2e-05 24.4 13.7 1.7 1 0 0 1 1 1 1 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 CRG89102.1 - 0.00065 19.6 7.0 0.0016 18.4 7.0 1.7 1 0 0 1 1 1 1 Glycine zipper Dehydrin PF00257.19 CRG89102.1 - 0.0078 16.8 4.1 0.016 15.8 4.1 1.4 1 0 0 1 1 1 1 Dehydrin TraT PF05818.12 CRG89102.1 - 0.072 12.8 3.0 0.15 11.8 3.0 1.4 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Zip PF02535.22 CRG89102.1 - 0.074 12.3 0.6 0.1 11.8 0.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF533 PF04391.12 CRG89102.1 - 0.14 11.7 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Gly-zipper_YMGG PF13441.6 CRG89102.1 - 0.4 10.5 14.4 0.83 9.4 14.4 1.5 1 0 0 1 1 1 0 YMGG-like Gly-zipper Bacteriocin_IIc PF10439.9 CRG89102.1 - 4.3 7.5 10.1 13 6.0 10.1 1.8 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide AP3D1 PF06375.11 CRG89102.1 - 9.9 6.4 12.8 26 5.0 12.8 1.6 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 LtrA PF06772.11 CRG89103.1 - 0.00086 18.6 5.6 0.00096 18.5 3.5 2.1 1 1 1 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) DUF3040 PF11239.8 CRG89103.1 - 0.041 14.2 1.3 0.041 14.2 1.3 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) DUF872 PF05915.12 CRG89103.1 - 6.7 6.9 5.8 1.4 9.1 0.6 2.4 2 1 0 3 3 3 0 Eukaryotic protein of unknown function (DUF872) TPR_2 PF07719.17 CRG89104.1 - 1.9e-14 52.5 5.6 1.9e-06 27.6 0.0 5.4 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 CRG89104.1 - 7.2e-14 50.9 0.7 4.6e-07 29.4 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG89104.1 - 5.6e-11 41.9 0.4 0.015 14.9 0.0 4.4 5 0 0 5 5 5 3 TPR repeat TPR_19 PF14559.6 CRG89104.1 - 1.8e-08 34.8 2.2 0.041 14.4 0.0 4.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89104.1 - 1e-07 32.2 3.6 0.032 14.5 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG89104.1 - 1.4e-07 31.2 0.1 0.089 13.0 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG89104.1 - 3.7e-05 23.4 0.1 2.8 8.2 0.0 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG89104.1 - 5.3e-05 23.7 10.6 1.3 10.0 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG89104.1 - 0.093 12.6 1.5 12 5.9 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG89104.1 - 0.24 12.1 0.1 0.24 12.1 0.1 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG89104.1 - 0.29 11.8 15.8 2.1 9.1 0.1 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_17 PF13431.6 CRG89104.1 - 0.5 10.9 7.4 56 4.4 0.1 4.9 5 1 0 5 5 5 0 Tetratricopeptide repeat adh_short_C2 PF13561.6 CRG89105.1 - 2.9e-30 105.5 0.2 3.7e-30 105.2 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89105.1 - 2.8e-19 69.3 0.1 3.4e-19 69.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89105.1 - 2.5e-07 30.8 0.2 4.5e-07 30.0 0.2 1.5 1 0 0 1 1 1 1 KR domain Oxidored_nitro PF00148.19 CRG89105.1 - 0.00026 19.9 0.0 0.00038 19.3 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase NAD_binding_7 PF13241.6 CRG89105.1 - 0.0045 17.4 0.1 0.01 16.3 0.1 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Epimerase PF01370.21 CRG89105.1 - 0.014 14.8 0.1 0.03 13.8 0.1 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Glyco_tran_WecB PF03808.13 CRG89105.1 - 0.021 14.8 0.1 0.068 13.1 0.1 2.0 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family CoA_binding_2 PF13380.6 CRG89105.1 - 0.045 14.3 0.2 0.1 13.1 0.1 1.8 2 0 0 2 2 2 0 CoA binding domain GDP_Man_Dehyd PF16363.5 CRG89105.1 - 0.046 13.1 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG89105.1 - 0.054 12.6 0.0 0.077 12.1 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 CRG89105.1 - 0.057 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Peptidase_C80 PF11713.8 CRG89105.1 - 0.066 13.4 0.0 0.096 12.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase C80 family F420_oxidored PF03807.17 CRG89105.1 - 0.067 13.8 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 CRG89105.1 - 0.08 12.5 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 CRG89105.1 - 0.082 12.3 0.1 0.17 11.2 0.1 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CRG89105.1 - 0.084 12.8 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Zn_clus PF00172.18 CRG89106.1 - 0.99 9.6 12.9 0.26 11.4 9.2 2.0 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Epimerase PF01370.21 CRG89107.1 - 7.1e-19 68.2 0.0 1.2e-18 67.4 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG89107.1 - 1.6e-14 53.6 0.0 2.9e-14 52.7 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG89107.1 - 1.5e-13 50.5 0.1 1.2e-06 27.8 0.0 2.2 1 1 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG89107.1 - 1.3e-09 38.0 0.0 2.2e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG89107.1 - 3.7e-08 33.5 0.1 5.3e-08 33.0 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CRG89107.1 - 4.1e-06 26.4 0.0 6.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89107.1 - 6.2e-06 26.2 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 KR domain NmrA PF05368.13 CRG89107.1 - 1.4e-05 24.8 0.5 5.1e-05 22.9 0.3 1.9 1 1 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 CRG89107.1 - 9.5e-05 21.7 0.1 0.00014 21.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CRG89107.1 - 0.001 18.3 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Shikimate_DH PF01488.20 CRG89107.1 - 0.018 15.1 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TFA2_Winged_2 PF18121.1 CRG89107.1 - 0.19 11.4 0.0 5.7 6.7 0.0 2.4 2 0 0 2 2 2 0 TFA2 Winged helix domain 2 adh_short PF00106.25 CRG89108.1 - 4.3e-47 160.1 0.1 5.4e-47 159.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89108.1 - 5.1e-31 108.0 0.1 6.5e-31 107.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89108.1 - 1.7e-07 31.4 0.0 3.1e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG89108.1 - 0.029 14.3 0.1 0.046 13.6 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding RmlD_sub_bind PF04321.17 CRG89108.1 - 0.063 12.4 0.3 0.16 11.0 0.0 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain Epimerase PF01370.21 CRG89108.1 - 0.076 12.5 0.1 0.18 11.3 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 CRG89109.1 - 6.5e-45 153.5 0.0 8.2e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89109.1 - 8e-36 123.3 0.0 9.8e-36 123.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89109.1 - 1.3e-11 44.7 0.3 3.7e-11 43.3 0.0 1.8 2 1 1 3 3 3 1 KR domain HATPase_c PF02518.26 CRG89109.1 - 0.032 14.7 0.0 0.066 13.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glyco_transf_5 PF08323.11 CRG89109.1 - 0.043 13.5 0.0 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Starch synthase catalytic domain SnoaL_2 PF12680.7 CRG89110.1 - 3.6e-08 34.0 0.2 4.6e-08 33.6 0.2 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 CRG89110.1 - 0.05 14.0 0.0 0.074 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Aldedh PF00171.22 CRG89111.1 - 2.3e-128 428.6 0.0 2.5e-128 428.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ADH_N PF08240.12 CRG89112.1 - 9e-23 80.2 4.0 1.7e-22 79.4 4.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89112.1 - 1.3e-22 80.2 0.0 5.6e-22 78.1 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG89112.1 - 7.1e-10 40.1 0.0 1.4e-09 39.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Fungal_trans PF04082.18 CRG89113.1 - 1.6e-30 106.0 0.1 3.2e-30 105.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89113.1 - 5.7e-10 39.1 7.4 9.6e-10 38.4 7.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EthD PF07110.11 CRG89113.1 - 0.032 15.4 0.5 21 6.3 0.0 2.9 3 0 0 3 3 3 0 EthD domain Cupin_2 PF07883.11 CRG89114.1 - 2.5e-24 84.8 0.7 5.5e-16 58.0 0.3 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CRG89114.1 - 0.00041 20.0 0.0 0.31 10.8 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 CRG89114.1 - 0.0016 18.4 0.4 0.0075 16.2 0.3 2.0 2 0 0 2 2 2 1 AraC-like ligand binding domain ARD PF03079.14 CRG89114.1 - 0.05 13.8 0.0 0.12 12.5 0.0 1.5 2 0 0 2 2 2 0 ARD/ARD' family Cupin_1 PF00190.22 CRG89114.1 - 0.11 12.0 0.0 7.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Cupin FAA_hydrolase PF01557.18 CRG89115.1 - 6.8e-60 202.4 0.0 8.4e-60 202.1 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Oxidored_FMN PF00724.20 CRG89116.1 - 2.2e-56 191.6 0.0 2.8e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF3674 PF12426.8 CRG89116.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 RNA dependent RNA polymerase Myb_DNA-binding PF00249.31 CRG89116.1 - 0.054 13.7 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain TRI12 PF06609.13 CRG89117.1 - 4.5e-62 210.3 18.7 5.9e-62 209.9 18.7 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CRG89117.1 - 3.5e-11 42.6 61.5 8.3e-11 41.4 56.0 3.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Transp_inhibit PF18791.1 CRG89117.1 - 0.16 11.5 0.4 0.34 10.4 0.4 1.5 1 0 0 1 1 1 0 Transport inhibitor response 1 protein domain Gln-synt_C PF00120.24 CRG89118.1 - 9.4e-69 232.0 0.0 1.2e-68 231.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain DUF3343 PF11823.8 CRG89118.1 - 0.11 11.9 0.0 0.57 9.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) Methyltransf_3 PF01596.17 CRG89119.1 - 4.6e-10 39.0 0.0 6.3e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 CRG89119.1 - 2.4e-08 34.9 0.3 5.8e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CmcI PF04989.12 CRG89119.1 - 0.15 11.7 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase DUF3431 PF11913.8 CRG89120.1 - 1.8e-66 224.0 0.0 2.4e-66 223.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) bZIP_1 PF00170.21 CRG89120.1 - 8.7e-05 22.5 6.2 0.0002 21.4 6.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor dCMP_cyt_deam_1 PF00383.23 CRG89120.1 - 0.00033 20.5 0.1 0.00064 19.6 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region bZIP_2 PF07716.15 CRG89120.1 - 0.03 14.4 10.5 0.12 12.5 10.5 2.0 1 1 0 1 1 1 0 Basic region leucine zipper PRKG1_interact PF15898.5 CRG89120.1 - 0.98 10.4 4.0 2.1 9.3 4.0 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF1635 PF07795.11 CRG89120.1 - 6.3 6.6 8.4 4.7 7.0 2.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1635) FAD_binding_3 PF01494.19 CRG89121.1 - 6.8e-16 58.4 1.4 8.3e-12 45.0 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG89121.1 - 5.4e-08 33.0 0.4 1.5e-07 31.5 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG89121.1 - 2.3e-06 27.5 3.5 4.2e-06 26.6 3.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG89121.1 - 7.9e-06 25.3 0.1 1.1e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG89121.1 - 0.00014 22.3 1.5 0.00038 21.0 1.5 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG89121.1 - 0.00032 20.2 0.1 0.00049 19.6 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG89121.1 - 0.00036 19.7 0.1 0.00054 19.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CRG89121.1 - 0.00098 18.3 0.1 0.0013 17.8 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Rossmann-like PF10727.9 CRG89121.1 - 0.005 16.7 0.6 0.0099 15.7 0.6 1.5 1 0 0 1 1 1 1 Rossmann-like domain GIDA PF01134.22 CRG89121.1 - 0.0073 15.4 1.2 0.013 14.6 1.2 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 CRG89121.1 - 0.012 15.0 0.1 0.019 14.2 0.1 1.3 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase 3HCDH_N PF02737.18 CRG89121.1 - 0.026 14.4 1.3 0.045 13.6 1.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 CRG89121.1 - 0.034 12.9 1.6 0.051 12.3 1.6 1.2 1 0 0 1 1 1 0 HI0933-like protein NAD_binding_2 PF03446.15 CRG89121.1 - 0.058 13.6 0.1 0.099 12.8 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CRG89121.1 - 0.065 13.2 0.8 0.11 12.5 0.8 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox_3 PF13738.6 CRG89121.1 - 0.17 11.1 1.5 0.14 11.3 0.2 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 CRG89121.1 - 0.31 10.3 1.9 0.27 10.5 0.3 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CRG89121.1 - 0.74 8.6 2.4 1.6 7.5 1.4 2.0 3 0 0 3 3 3 0 Tryptophan halogenase LigB PF02900.18 CRG89123.1 - 3.6e-37 127.9 0.0 4.5e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Fungal_trans_2 PF11951.8 CRG89124.1 - 0.0023 16.8 0.3 0.012 14.4 0.0 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF5435 PF17503.2 CRG89124.1 - 0.076 12.7 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5435) Myb_DNA-binding PF00249.31 CRG89124.1 - 0.18 12.0 0.0 0.44 10.8 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain Glyco_hydro_16 PF00722.21 CRG89125.1 - 8e-05 22.2 0.1 0.00012 21.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Aminotran_5 PF00266.19 CRG89126.1 - 5.1e-21 75.0 0.0 3.3e-13 49.4 0.0 2.6 2 1 0 2 2 2 2 Aminotransferase class-V SKG6 PF08693.10 CRG89127.1 - 1.3e-08 34.1 0.1 3.7e-08 32.6 0.1 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain PAXNEB PF05625.11 CRG89127.1 - 0.19 10.9 0.7 0.3 10.2 0.7 1.3 1 0 0 1 1 1 0 PAXNEB protein ADP_ribosyl_GH PF03747.14 CRG89128.1 - 4.8e-57 193.9 0.0 5.9e-57 193.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase GTA_TIM PF13547.6 CRG89128.1 - 0.036 13.4 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 GTA TIM-barrel-like domain Rick_17kDa_Anti PF05433.15 CRG89128.1 - 0.094 12.6 5.0 0.91 9.4 1.2 3.0 3 0 0 3 3 3 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 CRG89128.1 - 5.7 6.8 6.8 28 4.5 1.4 2.8 3 0 0 3 3 3 0 YMGG-like Gly-zipper GPI-anchored PF10342.9 CRG89129.1 - 6.9e-05 23.5 0.3 6.9e-05 23.5 0.3 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family FAD_binding_3 PF01494.19 CRG89130.1 - 8.3e-25 87.8 0.1 5.5e-18 65.3 0.2 2.9 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG89130.1 - 0.00017 21.7 0.3 0.00077 19.6 0.2 2.2 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG89130.1 - 0.0016 17.8 0.1 0.031 13.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG89130.1 - 0.0018 18.8 0.1 0.012 16.2 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG89130.1 - 0.0027 17.0 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG89130.1 - 0.0038 16.8 0.2 0.02 14.5 0.1 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase TrkA_N PF02254.18 CRG89130.1 - 0.013 15.7 0.0 0.028 14.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain ApbA PF02558.16 CRG89130.1 - 0.14 11.8 0.1 0.34 10.6 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Glyco_hydro_16 PF00722.21 CRG89131.1 - 1.7e-08 34.2 0.2 2.2e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 CRG89131.1 - 0.001 17.6 2.3 0.4 9.0 1.7 2.3 2 1 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) Ribosomal_L3 PF00297.22 CRG89133.1 - 4e-182 605.2 10.9 5e-182 604.9 10.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L3 Arrestin_N PF00339.29 CRG89133.1 - 2.6e-05 24.3 0.2 0.00044 20.3 0.2 2.9 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF2554 PF10829.8 CRG89133.1 - 0.37 11.2 3.1 17 5.9 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2554) NuiA PF07924.11 CRG89134.1 - 0.007 16.8 0.5 0.18 12.2 0.1 2.6 1 1 1 2 2 2 1 Nuclease A inhibitor-like protein GFO_IDH_MocA PF01408.22 CRG89135.1 - 2.2e-23 83.3 0.2 4.1e-23 82.5 0.2 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG89135.1 - 0.0003 21.4 0.1 0.00078 20.1 0.1 1.7 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DapB_N PF01113.20 CRG89135.1 - 0.0074 16.4 0.0 0.016 15.3 0.0 1.8 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Arginosuc_synth PF00764.19 CRG89136.1 - 7.6e-150 499.5 0.0 8.8e-150 499.3 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase tRNA_Me_trans PF03054.16 CRG89136.1 - 0.0056 15.5 0.0 0.008 15.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 CRG89136.1 - 0.014 14.9 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC SLC35F PF06027.12 CRG89137.1 - 9.2e-90 301.2 25.4 1.1e-89 300.9 25.4 1.1 1 0 0 1 1 1 1 Solute carrier family 35 Methyltransf_25 PF13649.6 CRG89137.1 - 1.5e-15 57.7 0.0 3e-15 56.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89137.1 - 5.3e-11 42.5 0.0 9.1e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG89137.1 - 6.9e-11 42.3 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89137.1 - 1.1e-09 38.8 0.0 2.2e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89137.1 - 5.1e-09 36.8 0.0 1.4e-08 35.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain CRT-like PF08627.10 CRG89137.1 - 1.5e-08 34.0 6.5 2.6e-08 33.2 6.5 1.3 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like MTS PF05175.14 CRG89137.1 - 1.7e-05 24.4 0.0 3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain EamA PF00892.20 CRG89137.1 - 7.5e-05 22.9 33.1 0.0068 16.6 15.3 2.4 2 1 0 2 2 2 2 EamA-like transporter family Methyltransf_32 PF13679.6 CRG89137.1 - 0.0023 17.9 0.0 0.0045 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 CRG89137.1 - 0.0034 16.7 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain FtsJ PF01728.19 CRG89137.1 - 0.0056 16.8 0.0 0.018 15.1 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase MDMPI_N PF11716.8 CRG89137.1 - 0.05 14.3 1.0 0.11 13.1 1.0 1.5 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain Methyltransf_4 PF02390.17 CRG89137.1 - 0.08 12.4 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase AA_permease PF00324.21 CRG89139.1 - 1.7e-107 360.0 41.7 2.1e-107 359.7 41.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG89139.1 - 6.6e-30 104.3 44.2 8.7e-30 103.9 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease Adeno_E3B PF03376.14 CRG89139.1 - 5.5 7.3 8.9 0.38 11.0 1.9 2.7 3 0 0 3 3 3 0 Adenovirus E3B protein AAA_16 PF13191.6 CRG89140.1 - 1.4e-06 28.8 0.1 1.4e-06 28.8 0.1 3.8 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 CRG89140.1 - 2.8e-06 27.6 0.0 2.8e-05 24.4 0.0 2.9 1 1 0 1 1 1 1 AAA domain TPR_12 PF13424.6 CRG89140.1 - 1.2e-05 25.5 19.3 0.055 13.8 0.0 8.2 8 1 0 8 8 8 2 Tetratricopeptide repeat NACHT PF05729.12 CRG89140.1 - 0.00017 21.5 0.0 0.00061 19.7 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA PF00004.29 CRG89140.1 - 0.0092 16.4 0.4 0.14 12.6 0.0 3.3 2 2 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 CRG89140.1 - 0.021 15.2 0.0 0.14 12.5 0.0 2.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 CRG89140.1 - 0.056 14.0 0.0 0.74 10.4 0.0 2.8 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 CRG89140.1 - 0.076 13.5 0.7 1.5 9.4 0.0 3.4 2 1 1 3 3 3 0 ABC transporter TPR_3 PF07720.12 CRG89140.1 - 0.3 11.1 3.3 7.1 6.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 CRG89140.1 - 1.9 8.5 13.4 51 3.9 0.2 6.9 8 0 0 8 8 8 0 Tetratricopeptide repeat Asp PF00026.23 CRG89143.1 - 1.5e-36 126.5 0.8 1.7e-36 126.2 0.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG89143.1 - 0.0032 17.7 1.0 0.11 12.7 0.2 2.9 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CRG89143.1 - 0.042 13.6 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 CRG89143.1 - 0.19 12.3 0.0 39 4.9 0.0 2.8 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease Abhydrolase_6 PF12697.7 CRG89144.1 - 1.2e-13 52.2 0.2 8.5e-13 49.4 0.2 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG89144.1 - 0.00023 20.9 0.0 0.00036 20.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_A4 PF01828.17 CRG89146.1 - 2.7e-73 245.9 15.3 3.3e-73 245.6 15.3 1.1 1 0 0 1 1 1 1 Peptidase A4 family Arylesterase PF01731.20 CRG89147.1 - 0.0062 16.7 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Arylesterase SAT PF16073.5 CRG89148.1 - 9e-49 166.4 0.2 1.1e-48 166.1 0.2 1.1 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis CoA_transf_3 PF02515.17 CRG89149.1 - 7.7e-36 124.0 0.0 1.6e-35 123.0 0.0 1.5 1 0 0 1 1 1 1 CoA-transferase family III MFS_1 PF07690.16 CRG89150.1 - 8e-16 57.9 84.1 1.3e-14 53.9 44.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short_C2 PF13561.6 CRG89151.1 - 3.8e-36 124.8 0.0 7.5e-36 123.8 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89151.1 - 2e-29 102.5 0.1 1.1e-28 100.1 0.0 2.0 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG89151.1 - 5.9e-08 32.8 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 KR domain FAD_binding_3 PF01494.19 CRG89152.1 - 6.2e-55 186.8 0.0 8.4e-55 186.4 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CRG89152.1 - 3.8e-05 23.2 0.4 6.1e-05 22.6 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG89152.1 - 4.1e-05 23.0 0.1 0.00072 18.9 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG89152.1 - 4.2e-05 22.4 1.1 0.00021 20.1 0.1 2.3 3 0 0 3 3 3 1 HI0933-like protein DAO PF01266.24 CRG89152.1 - 0.00022 20.9 0.1 0.012 15.2 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG89152.1 - 0.0018 17.6 0.0 0.0037 16.6 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CRG89152.1 - 0.0019 17.5 0.3 0.16 11.2 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG89152.1 - 0.0022 17.2 0.1 0.0035 16.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CRG89152.1 - 0.0023 17.0 0.2 0.034 13.2 0.2 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CRG89152.1 - 0.0033 17.6 0.1 0.01 16.1 0.1 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG89152.1 - 0.0086 16.6 0.1 0.057 14.0 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG89152.1 - 0.022 14.1 0.0 0.047 13.0 0.0 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.22 CRG89152.1 - 0.036 13.2 0.1 0.07 12.2 0.1 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A DIT1_PvcA PF05141.12 CRG89153.1 - 1.5e-91 306.7 0.0 1.9e-91 306.4 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein TauD PF02668.16 CRG89153.1 - 6e-25 88.5 0.0 1.4e-24 87.4 0.0 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family WW_1 PF18507.1 CRG89153.1 - 0.0076 15.9 0.1 0.022 14.4 0.1 1.8 1 0 0 1 1 1 1 WW domain Flagellin_IN PF07196.13 CRG89154.1 - 0.35 11.1 7.6 4.6 7.5 0.1 3.0 3 0 0 3 3 3 0 Flagellin hook IN motif Sugar_tr PF00083.24 CRG89155.1 - 2.8e-105 352.8 23.0 3.4e-105 352.5 23.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89155.1 - 2.3e-24 86.0 33.1 7.2e-19 67.9 12.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG89155.1 - 1.6e-07 30.3 21.6 0.00011 21.0 2.0 3.2 2 2 1 3 3 3 2 MFS/sugar transport protein MFS_3 PF05977.13 CRG89155.1 - 0.0028 16.1 0.1 0.0054 15.2 0.1 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector DUF3792 PF12670.7 CRG89155.1 - 2.4 8.3 25.0 0.62 10.2 6.8 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3792) ADH_N PF08240.12 CRG89156.1 - 3.7e-19 68.6 2.6 6.5e-19 67.8 2.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89156.1 - 2.5e-10 40.4 0.0 4.3e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG89156.1 - 0.00055 19.4 0.0 0.00088 18.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CRG89156.1 - 0.042 13.1 0.0 0.059 12.7 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 CRG89157.1 - 3.4e-20 72.3 0.0 4.7e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89157.1 - 6.6e-19 68.4 0.0 9.4e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_25 PF13649.6 CRG89158.1 - 5.3e-11 43.1 0.0 2e-10 41.2 0.0 2.0 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG89158.1 - 8e-11 42.1 0.0 1.5e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89158.1 - 6.1e-10 39.6 0.0 8.7e-09 35.9 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89158.1 - 2.1e-08 34.1 0.0 4.3e-08 33.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89158.1 - 2.8e-07 31.2 0.0 4.5e-06 27.3 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG89158.1 - 0.0031 16.9 0.0 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CheR PF01739.18 CRG89158.1 - 0.013 15.0 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.17 CRG89158.1 - 0.087 12.3 0.0 2.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_3 PF01596.17 CRG89158.1 - 0.16 11.1 0.0 0.34 10.0 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase ADH_zinc_N PF00107.26 CRG89160.1 - 2.7e-09 37.1 0.1 4e-09 36.5 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG89160.1 - 0.087 13.9 0.0 0.17 13.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Terpene_synth_C PF03936.16 CRG89161.1 - 8.1e-08 31.9 0.1 9.7e-08 31.7 0.1 1.0 1 0 0 1 1 1 1 Terpene synthase family, metal binding domain TRI5 PF06330.11 CRG89161.1 - 0.00018 20.5 0.1 0.00018 20.5 0.1 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) APG17 PF04108.12 CRG89161.1 - 0.0051 16.0 0.0 0.0066 15.6 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 p450 PF00067.22 CRG89162.1 - 4.7e-40 137.7 0.1 6.9e-40 137.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome P450 Caps_synth PF05704.12 CRG89163.1 - 1.2e-11 44.6 0.0 2.9e-11 43.3 0.0 1.6 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 CRG89163.1 - 0.00011 22.8 0.0 0.0002 21.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif CM1 PF03026.15 CRG89163.1 - 0.23 10.8 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Influenza C virus M1 protein ADH_zinc_N PF00107.26 CRG89164.1 - 6.1e-20 71.5 0.0 9.6e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CRG89164.1 - 1.6e-14 53.7 0.0 2.8e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CRG89164.1 - 1.5e-06 29.3 0.0 3.2e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF2855 PF11017.8 CRG89164.1 - 0.066 13.0 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2855) p450 PF00067.22 CRG89165.1 - 6.1e-66 223.1 0.0 8.5e-66 222.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG89165.1 - 4e-22 78.6 58.8 1.1e-21 77.2 40.5 2.5 2 1 1 3 3 3 2 Major Facilitator Superfamily YCII PF03795.14 CRG89165.1 - 9.9e-05 22.7 0.0 0.00025 21.4 0.0 1.7 1 0 0 1 1 1 1 YCII-related domain FAD_binding_3 PF01494.19 CRG89166.1 - 6.2e-25 88.2 0.5 2e-23 83.2 0.5 2.2 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG89166.1 - 1.1e-06 28.1 0.4 0.00052 19.3 0.1 3.0 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG89166.1 - 4.7e-06 26.7 0.1 2.1e-05 24.6 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG89166.1 - 0.0009 18.9 1.0 0.023 14.3 0.3 2.3 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG89166.1 - 0.0025 17.8 0.2 0.064 13.3 0.1 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG89166.1 - 0.0046 16.1 0.1 0.78 8.7 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG89166.1 - 0.0055 16.0 0.0 1 8.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG89166.1 - 0.012 14.9 0.0 0.025 13.8 0.0 1.5 1 0 0 1 1 1 0 Thi4 family HI0933_like PF03486.14 CRG89166.1 - 0.025 13.3 0.1 0.094 11.4 0.0 1.8 2 0 0 2 2 2 0 HI0933-like protein ketoacyl-synt PF00109.26 CRG89167.1 - 9.6e-73 244.9 0.0 1.7e-72 244.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG89167.1 - 1.2e-60 204.5 0.0 2.3e-60 203.6 0.0 1.5 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CRG89167.1 - 6.8e-57 193.0 0.0 1.5e-56 191.9 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG89167.1 - 8.1e-40 137.3 0.1 1.5e-39 136.4 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG89167.1 - 1.1e-34 119.0 0.0 2.7e-34 117.7 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG89167.1 - 2.9e-21 76.9 0.0 4.1e-18 66.7 0.0 2.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 CRG89167.1 - 5.6e-19 68.7 0.0 5.1e-18 65.7 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG89167.1 - 8.6e-17 61.6 0.1 1.7e-15 57.5 0.1 2.7 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CRG89167.1 - 6.4e-14 52.0 0.0 1.8e-12 47.4 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 CRG89167.1 - 1.3e-09 38.1 0.0 3e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89167.1 - 4.9e-09 36.8 0.0 2e-08 34.8 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89167.1 - 3.1e-08 34.2 0.0 1.1e-07 32.4 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CRG89167.1 - 1.5e-07 31.1 0.0 1.4e-06 27.9 0.0 2.5 3 0 0 3 3 3 1 short chain dehydrogenase Ubie_methyltran PF01209.18 CRG89167.1 - 2.3e-07 30.4 0.0 4.8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 CRG89167.1 - 1.9e-06 27.7 0.2 4.8e-06 26.4 0.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 CRG89167.1 - 0.00013 22.2 0.0 0.0043 17.4 0.0 3.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 CRG89167.1 - 0.00042 20.1 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CRG89167.1 - 0.012 15.0 0.1 0.024 14.0 0.1 1.4 1 0 0 1 1 1 0 Thiolase, N-terminal domain ACP_syn_III PF08545.10 CRG89167.1 - 0.12 12.2 0.1 0.32 10.9 0.1 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_33 PF10017.9 CRG89167.1 - 0.19 10.9 0.0 0.51 9.4 0.0 1.6 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent SapA PF02199.15 CRG89167.1 - 0.2 12.0 0.1 0.48 10.7 0.1 1.6 1 0 0 1 1 1 0 Saposin A-type domain GRDP-like PF07173.12 CRG89168.1 - 3.9e-16 60.0 0.3 1.1e-15 58.6 0.3 1.7 1 1 0 1 1 1 1 Glycine-rich domain-containing protein-like DUF1100 PF06500.11 CRG89168.1 - 1.1e-11 44.2 0.0 1.7e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) BAAT_C PF08840.11 CRG89168.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Beta-lactamase PF00144.24 CRG89169.1 - 8e-54 183.1 0.2 1.1e-53 182.7 0.2 1.0 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 CRG89169.1 - 0.0099 15.3 0.1 0.038 13.4 0.1 1.8 2 0 0 2 2 2 1 D-alanyl-D-alanine carboxypeptidase NLPC_P60 PF00877.19 CRG89172.1 - 9.4e-19 67.4 0.0 3.1e-18 65.7 0.0 1.7 2 0 0 2 2 2 1 NlpC/P60 family Amidase_5 PF05382.13 CRG89172.1 - 8.1e-05 22.6 0.1 0.00014 21.8 0.1 1.4 1 0 0 1 1 1 1 Bacteriophage peptidoglycan hydrolase DUF1175 PF06672.11 CRG89172.1 - 0.018 14.7 0.0 1.6 8.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1175) SH3_3 PF08239.11 CRG89172.1 - 0.039 14.2 0.0 0.081 13.2 0.0 1.6 1 1 0 1 1 1 0 Bacterial SH3 domain Fungus-induced PF10917.8 CRG89172.1 - 0.075 13.4 4.0 2.1 8.8 0.1 2.6 2 0 0 2 2 2 0 Fungus-induced protein SH3_3 PF08239.11 CRG89173.1 - 7e-05 23.0 0.1 0.00014 22.1 0.1 1.5 1 0 0 1 1 1 1 Bacterial SH3 domain BcrAD_BadFG PF01869.20 CRG89174.1 - 4.9e-18 65.6 0.6 4.9e-18 65.6 0.6 1.9 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family SIS_2 PF13580.6 CRG89174.1 - 0.00015 21.8 0.0 0.0028 17.7 0.0 2.6 1 1 0 1 1 1 1 SIS domain SIS PF01380.22 CRG89174.1 - 0.0018 18.1 0.1 0.014 15.3 0.0 2.4 2 0 0 2 2 2 1 SIS domain PLDc_2 PF13091.6 CRG89174.1 - 0.11 12.4 0.0 0.64 9.9 0.0 2.2 3 0 0 3 3 3 0 PLD-like domain MFS_1 PF07690.16 CRG89175.1 - 2.7e-12 46.3 30.9 4.7e-12 45.5 30.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG89175.1 - 4.1e-11 42.8 5.1 4.1e-11 42.8 5.1 2.3 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF2293 PF10056.9 CRG89176.1 - 2.3e-29 101.5 0.1 6.7e-29 100.0 0.1 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2293) TruD PF01142.18 CRG89177.1 - 4.5e-69 233.3 0.0 3.4e-64 217.2 0.0 3.2 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) Bac_RepA_C PF18008.1 CRG89177.1 - 0.17 12.2 0.0 0.56 10.6 0.0 1.9 2 0 0 2 2 2 0 Replication initiator protein A C-terminal domain SPT6_acidic PF14632.6 CRG89177.1 - 0.45 11.1 8.5 0.046 14.3 3.4 2.0 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Vps54 PF07928.12 CRG89178.1 - 2.8e-30 105.5 1.4 1.7e-29 102.9 1.4 2.1 1 1 0 1 1 1 1 Vps54-like protein Vps54_N PF10475.9 CRG89179.1 - 0.0013 18.1 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Aconitase PF00330.20 CRG89180.1 - 4.4e-109 365.5 0.0 4.1e-108 362.3 0.0 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 CRG89180.1 - 4.8e-24 85.2 0.0 9.2e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF3328 PF11807.8 CRG89182.1 - 2.4e-26 92.9 9.7 1.6e-24 86.9 9.7 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CRG89183.1 - 6.1e-42 143.9 1.4 7.7e-42 143.5 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Cytochrom_C_asm PF01578.20 CRG89183.1 - 0.14 11.9 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C assembly protein Spt20 PF12090.8 CRG89185.1 - 1.5e-51 175.2 6.5 1.5e-51 175.2 6.5 6.6 3 2 0 3 3 3 1 Spt20 family zf-C2H2 PF00096.26 CRG89186.1 - 1.5e-08 34.6 10.2 0.0004 20.7 3.3 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG89186.1 - 2.2e-05 24.9 6.2 0.0051 17.5 2.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG89186.1 - 0.00012 22.3 2.9 0.00012 22.3 2.9 3.4 4 0 0 4 4 4 1 Zinc-finger double domain FOXP-CC PF16159.5 CRG89186.1 - 0.0039 17.8 3.3 1.1 9.9 0.2 2.5 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-met PF12874.7 CRG89186.1 - 0.65 10.5 2.8 37 4.9 0.0 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CRG89186.1 - 0.73 9.9 9.1 4.4 7.4 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HE PF16278.5 CRG89186.1 - 0.74 10.3 3.5 1.6 9.3 3.5 1.5 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 CRG89186.1 - 3.1 8.2 7.8 23 5.4 2.5 2.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MFS_1 PF07690.16 CRG89187.1 - 2.5e-15 56.3 41.0 2e-12 46.7 13.7 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG89187.1 - 6.5e-06 24.7 2.8 1.2e-05 23.9 2.8 1.4 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Tmemb_170 PF10190.9 CRG89187.1 - 0.029 14.7 0.3 0.029 14.7 0.3 3.6 4 0 0 4 4 4 0 Putative transmembrane protein 170 Ribonuclease_T2 PF00445.18 CRG89188.1 - 1.9e-40 139.1 0.9 2.6e-40 138.6 0.9 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family DUF1344 PF07076.11 CRG89188.1 - 0.15 12.0 0.1 0.37 10.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1344) BCNT PF07572.12 CRG89189.1 - 2.3e-27 94.8 1.4 5.2e-27 93.7 1.4 1.6 1 0 0 1 1 1 1 Bucentaur or craniofacial development DUF1248 PF06852.12 CRG89189.1 - 0.059 12.9 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1248) Hexapep PF00132.24 CRG89190.1 - 3.1e-08 33.0 2.7 0.0048 16.6 0.1 2.8 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 CRG89190.1 - 1.1e-05 24.6 1.7 0.0095 14.9 0.0 2.1 1 1 1 2 2 2 2 L-fucokinase NTP_transf_3 PF12804.7 CRG89190.1 - 0.018 15.4 0.0 0.036 14.4 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain NTP_transferase PF00483.23 CRG89190.1 - 0.17 11.4 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase DUF4954 PF16314.5 CRG89190.1 - 0.28 9.3 0.7 0.97 7.5 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4954) ketoacyl-synt PF00109.26 CRG89192.1 - 2.7e-75 253.2 0.0 5e-75 252.3 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain AMP-binding PF00501.28 CRG89192.1 - 5.5e-73 246.0 0.0 8.8e-73 245.3 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CRG89192.1 - 1.1e-65 222.1 0.3 1.7e-65 221.5 0.3 1.2 1 0 0 1 1 1 1 Condensation domain PS-DH PF14765.6 CRG89192.1 - 1.5e-49 168.8 0.0 2.4e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CRG89192.1 - 7.1e-49 166.1 0.0 3.1e-48 164.1 0.0 2.0 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 CRG89192.1 - 7.7e-42 143.9 0.0 1.5e-41 142.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain NAD_binding_4 PF07993.12 CRG89192.1 - 5.5e-28 97.8 0.0 1.4e-27 96.5 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein Ketoacyl-synt_C PF02801.22 CRG89192.1 - 3.4e-26 91.6 0.0 8.4e-26 90.3 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 CRG89192.1 - 6.9e-21 74.4 0.3 6e-10 39.3 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 CRG89192.1 - 2.8e-20 72.9 0.0 1.6e-19 70.5 0.0 2.5 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG89192.1 - 7.8e-15 55.3 0.0 3.5e-14 53.2 0.0 2.1 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 CRG89192.1 - 1.4e-14 54.2 0.0 4.4e-14 52.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89192.1 - 5.8e-14 52.6 0.0 2.8e-13 50.4 0.0 2.4 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CRG89192.1 - 1.2e-13 51.1 0.0 1.5e-07 31.2 0.0 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG89192.1 - 2.4e-11 43.2 0.0 9.5e-08 31.4 0.0 2.3 2 0 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_11 PF08241.12 CRG89192.1 - 4.2e-11 43.4 0.0 1.4e-10 41.6 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CRG89192.1 - 1.3e-10 41.1 0.0 5e-09 35.9 0.0 3.2 3 0 0 3 3 3 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CRG89192.1 - 7.1e-10 38.9 0.0 3.6e-09 36.6 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CRG89192.1 - 1.5e-06 27.8 0.0 3.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain adh_short_C2 PF13561.6 CRG89192.1 - 9.5e-06 25.3 0.0 2.6e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 CRG89192.1 - 0.0013 18.2 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GDP_Man_Dehyd PF16363.5 CRG89192.1 - 0.0018 17.8 0.0 0.028 13.8 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Methyltransf_16 PF10294.9 CRG89192.1 - 0.0019 18.0 0.0 0.0052 16.5 0.0 1.7 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_33 PF10017.9 CRG89192.1 - 0.15 11.2 0.0 0.46 9.6 0.0 1.8 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent MFS_1 PF07690.16 CRG89194.1 - 2.2e-42 145.3 58.2 2.2e-42 145.3 58.2 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG89194.1 - 8.5e-16 57.5 8.4 8.5e-16 57.5 8.4 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF4337 PF14235.6 CRG89194.1 - 2 8.5 5.1 1.4 9.1 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) ADH_zinc_N PF00107.26 CRG89195.1 - 9.2e-12 45.1 0.0 1.7e-11 44.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG89195.1 - 8e-06 26.9 0.0 1.6e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG89195.1 - 4.3e-05 23.4 0.1 0.00033 20.5 0.0 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain FAD_binding_4 PF01565.23 CRG89196.1 - 2.1e-27 95.5 3.0 3.7e-27 94.8 3.0 1.4 1 0 0 1 1 1 1 FAD binding domain NBD_C PF17042.5 CRG89196.1 - 0.12 12.8 0.5 6.9 7.2 0.3 2.4 2 0 0 2 2 2 0 Nucleotide-binding C-terminal domain SnoaL_2 PF12680.7 CRG89197.1 - 2.3e-09 37.8 0.2 3.1e-09 37.4 0.2 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL PF07366.12 CRG89197.1 - 3.9e-08 33.1 0.1 5e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase DUF4440 PF14534.6 CRG89197.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4440) FAD_binding_4 PF01565.23 CRG89198.1 - 3.4e-22 78.7 1.5 6.5e-22 77.8 1.5 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG89198.1 - 0.0014 18.7 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like NEAT PF05031.12 CRG89198.1 - 0.14 12.8 0.0 0.38 11.4 0.0 1.7 1 1 0 1 1 1 0 Iron Transport-associated domain Zn_clus PF00172.18 CRG89199.1 - 3e-06 27.3 10.1 1.4e-05 25.1 3.6 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain FKBP_C PF00254.28 CRG89201.1 - 7.5e-32 109.5 0.0 8.5e-32 109.4 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase MFS_1 PF07690.16 CRG89202.1 - 1.4e-37 129.4 24.6 1.4e-37 129.4 24.6 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89202.1 - 1.1e-10 41.0 15.7 1.5e-10 40.5 15.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter ALMT PF11744.8 CRG89202.1 - 8.6 5.1 6.7 0.84 8.4 2.0 1.6 2 0 0 2 2 2 0 Aluminium activated malate transporter ELO PF01151.18 CRG89203.1 - 3.5e-82 275.7 5.8 4.4e-82 275.4 5.8 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family HBM PF16591.5 CRG89203.1 - 0.11 11.9 0.1 0.16 11.3 0.1 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain ABM PF03992.16 CRG89204.1 - 0.00011 22.2 0.0 0.00021 21.3 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase AIM3 PF17096.5 CRG89204.1 - 0.0044 17.9 0.0 0.0044 17.9 0.0 5.4 4 2 1 5 5 5 1 Altered inheritance of mitochondria protein 3 G3P_acyltransf PF02660.15 CRG89205.1 - 0.5 10.4 8.6 1.1 9.3 0.8 2.5 1 1 1 2 2 2 0 Glycerol-3-phosphate acyltransferase K_trans PF02705.16 CRG89206.1 - 5.7e-159 530.0 15.9 2.8e-80 270.4 4.1 2.2 1 1 1 2 2 2 2 K+ potassium transporter adh_short_C2 PF13561.6 CRG89206.1 - 7.5e-40 136.9 0.1 1.2e-39 136.2 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89206.1 - 1.4e-35 122.6 0.0 2.2e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89206.1 - 2.6e-07 30.8 0.2 7.4e-07 29.2 0.1 1.7 2 0 0 2 2 2 1 KR domain CMD PF02627.20 CRG89207.1 - 4.6e-05 23.4 0.0 0.00021 21.2 0.0 2.0 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Mis12 PF05859.12 CRG89209.1 - 3.2e-45 153.5 0.1 6.3e-45 152.6 0.1 1.5 1 0 0 1 1 1 1 Mis12 protein Fungal_trans PF04082.18 CRG89209.1 - 0.0033 16.5 0.0 0.0071 15.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain CENP-X PF09415.10 CRG89210.1 - 3.2e-28 97.8 0.0 6.9e-28 96.8 0.0 1.6 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 CRG89210.1 - 0.0068 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SPX PF03105.19 CRG89210.1 - 0.75 9.6 12.1 0.88 9.4 12.1 1.1 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 CRG89210.1 - 3.7 6.1 5.2 4.1 6.0 5.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SUN PF03856.13 CRG89211.1 - 4e-77 259.0 8.2 6.9e-77 258.2 8.2 1.4 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) CDC27 PF09507.10 CRG89211.1 - 2.8 7.2 17.1 4.7 6.5 17.1 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Pol_alpha_B_N PF08418.10 CRG89211.1 - 5.6 6.9 14.8 10 6.0 14.8 1.5 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal Hid1 PF12722.7 CRG89211.1 - 6.1 4.8 9.2 8.2 4.4 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF953 PF06110.11 CRG89212.1 - 1.9e-17 63.0 0.0 2.2e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 CRG89212.1 - 0.003 17.3 0.0 0.004 16.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Ist1 PF03398.14 CRG89213.1 - 2.8e-44 150.9 4.9 5.6e-22 78.4 2.7 3.0 3 0 0 3 3 3 2 Regulator of Vps4 activity in the MVB pathway CN_hydrolase PF00795.22 CRG89213.1 - 5.2e-41 140.7 0.0 7.3e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 CRG89213.1 - 1.2e-24 86.8 0.0 3e-24 85.5 0.0 1.6 1 1 0 1 1 1 1 NAD synthase SAPS PF04499.15 CRG89213.1 - 0.013 14.3 0.1 0.024 13.4 0.1 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Clat_adaptor_s PF01217.20 CRG89215.1 - 1.8e-55 186.8 1.7 2.1e-55 186.6 1.7 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TP_methylase PF00590.20 CRG89216.1 - 2.2e-24 86.6 0.1 3.7e-24 85.9 0.1 1.3 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases TFIID-18kDa PF02269.16 CRG89217.1 - 1.2e-32 111.8 0.4 1.6e-31 108.1 0.3 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit TAFII28 PF04719.14 CRG89217.1 - 0.038 14.1 0.1 0.096 12.8 0.0 1.8 2 0 0 2 2 2 0 hTAFII28-like protein conserved region Pyrid_ox_like PF16242.5 CRG89218.1 - 7.3e-17 61.3 0.0 1e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 CRG89218.1 - 0.00029 21.0 0.0 0.00047 20.3 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 CRG89218.1 - 0.065 12.9 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative FMN-binding domain F-box-like PF12937.7 CRG89219.1 - 0.0011 18.8 0.0 0.0025 17.7 0.0 1.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CRG89219.1 - 0.0015 18.4 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 F-box domain zf-RING_6 PF14835.6 CRG89219.1 - 0.077 12.9 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein AMP-binding PF00501.28 CRG89220.1 - 2.5e-91 306.4 0.0 3.1e-91 306.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG89220.1 - 2.4e-12 47.7 0.1 5.4e-12 46.5 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Abhydrolase_3 PF07859.13 CRG89221.1 - 1.5e-55 188.4 0.0 1.8e-55 188.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG89221.1 - 5.8e-06 25.4 0.0 7.9e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 CRG89221.1 - 0.0037 16.8 0.0 0.02 14.3 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family COesterase PF00135.28 CRG89221.1 - 0.0055 15.6 0.0 0.0094 14.9 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family DLH PF01738.18 CRG89221.1 - 0.018 14.6 0.0 0.088 12.4 0.0 1.9 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 CRG89221.1 - 0.073 13.7 0.6 0.1 13.1 0.6 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family NAD_binding_4 PF07993.12 CRG89222.1 - 0.032 13.4 0.0 0.16 11.1 0.0 1.9 2 0 0 2 2 2 0 Male sterility protein KR PF08659.10 CRG89222.1 - 0.06 13.3 0.0 0.093 12.6 0.0 1.2 1 0 0 1 1 1 0 KR domain Cyclase PF04199.13 CRG89223.1 - 4.2e-10 40.0 0.0 9.7e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 Putative cyclase Sugar_tr PF00083.24 CRG89224.1 - 3.9e-77 260.0 26.7 4.5e-77 259.8 26.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89224.1 - 2.9e-17 62.7 41.8 2.3e-13 49.8 36.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MmgE_PrpD PF03972.14 CRG89225.1 - 2.3e-117 392.2 0.2 3e-117 391.9 0.2 1.1 1 0 0 1 1 1 1 MmgE/PrpD family Fungal_trans PF04082.18 CRG89226.1 - 1.2e-17 63.9 0.4 2e-17 63.1 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Striatin PF08232.12 CRG89226.1 - 0.06 13.9 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 Striatin family zf-C2H2_jaz PF12171.8 CRG89227.1 - 2.2e-08 34.2 0.4 3.9e-08 33.4 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG89227.1 - 5.1e-06 26.7 0.5 9.3e-06 25.9 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 CRG89227.1 - 0.00095 19.5 0.4 0.0016 18.8 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 CRG89227.1 - 0.13 12.6 0.2 0.4 11.0 0.1 1.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) CDC27 PF09507.10 CRG89227.1 - 3.4 6.9 16.0 0.15 11.5 8.7 1.9 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Ribosomal_L34e PF01199.18 CRG89227.1 - 3.8 7.9 5.8 0.41 11.0 0.3 2.1 2 1 0 2 2 2 0 Ribosomal protein L34e BIR PF00653.21 CRG89228.1 - 7e-46 154.8 4.2 4.7e-23 81.6 0.0 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain Tam41_Mmp37 PF09139.11 CRG89229.1 - 2.6e-129 431.3 0.0 3.2e-129 431.0 0.0 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Aminotran_1_2 PF00155.21 CRG89230.1 - 4.5e-62 210.3 0.0 5.5e-62 210.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CRG89230.1 - 0.0069 15.0 0.0 0.024 13.2 0.0 1.7 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.13 CRG89230.1 - 0.076 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Allinase CAP160 PF07918.11 CRG89230.1 - 0.19 11.5 0.7 0.39 10.5 0.7 1.5 1 0 0 1 1 1 0 CAP160 repeat bZIP_1 PF00170.21 CRG89231.1 - 1.8e-11 44.0 3.5 3.1e-11 43.2 3.5 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 CRG89231.1 - 8.8e-07 28.9 5.4 2e-06 27.8 5.4 1.6 1 0 0 1 1 1 1 Basic region leucine zipper ASD2 PF08687.11 CRG89231.1 - 0.0096 15.5 1.5 0.012 15.2 1.5 1.1 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 DUF812 PF05667.11 CRG89231.1 - 0.015 14.2 1.9 0.019 13.9 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ABC_tran_CTD PF16326.5 CRG89231.1 - 0.018 15.3 1.5 0.032 14.5 1.5 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain Allexi_40kDa PF05549.11 CRG89231.1 - 0.024 14.1 0.7 0.041 13.4 0.7 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein ATG16 PF08614.11 CRG89231.1 - 0.041 14.1 6.9 0.056 13.7 6.9 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Muted PF14942.6 CRG89231.1 - 0.045 14.1 3.0 0.073 13.4 3.0 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein AATF-Che1 PF13339.6 CRG89231.1 - 0.052 14.2 0.7 0.052 14.2 0.7 2.1 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor Lectin_N PF03954.14 CRG89231.1 - 0.056 13.2 0.3 0.12 12.1 0.3 1.5 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Jnk-SapK_ap_N PF09744.9 CRG89231.1 - 0.068 13.4 2.7 0.1 12.8 2.7 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 CRG89231.1 - 0.078 13.1 3.2 0.076 13.1 2.0 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_Maf PF03131.17 CRG89231.1 - 0.41 11.2 13.5 0.079 13.5 8.2 2.3 1 1 0 2 2 2 0 bZIP Maf transcription factor M PF02370.16 CRG89231.1 - 0.77 10.5 4.4 0.22 12.2 0.8 2.1 2 0 0 2 2 1 0 M protein repeat CDC45 PF02724.14 CRG89231.1 - 2.3 6.4 8.3 2.9 6.1 8.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.11 CRG89231.1 - 2.5 6.8 6.9 2.9 6.6 6.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 WD40 PF00400.32 CRG89233.1 - 3.5e-70 230.2 28.2 4.8e-07 30.4 0.1 12.9 13 0 0 13 13 12 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG89233.1 - 1.6e-30 105.3 3.0 0.009 16.3 0.0 10.1 3 2 5 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 CRG89233.1 - 3.4e-13 49.8 0.1 7.7e-13 48.7 0.1 1.6 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 CRG89233.1 - 9.4e-11 41.2 6.8 0.86 8.5 0.1 7.4 4 3 4 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CRG89233.1 - 4.6e-07 29.6 1.6 10 6.2 0.0 7.7 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 CRG89233.1 - 9.9e-07 28.6 3.4 0.065 12.8 2.2 4.6 3 1 2 5 5 5 3 PQQ-like domain Nup160 PF11715.8 CRG89233.1 - 1.6e-05 23.7 3.9 0.16 10.6 0.1 5.3 3 1 3 6 6 6 1 Nucleoporin Nup120/160 eIF2A PF08662.11 CRG89233.1 - 2.6e-05 24.2 0.0 0.12 12.2 0.0 4.4 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A RAB3GAP2_N PF14655.6 CRG89233.1 - 2.8e-05 23.6 0.0 0.69 9.1 0.0 4.0 4 0 0 4 4 4 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Nbas_N PF15492.6 CRG89233.1 - 0.00074 18.9 3.7 0.61 9.4 0.0 5.3 4 2 1 6 6 6 1 Neuroblastoma-amplified sequence, N terminal Lactonase PF10282.9 CRG89233.1 - 0.0014 18.0 0.0 0.51 9.5 0.0 3.2 4 0 0 4 4 4 1 Lactonase, 7-bladed beta-propeller Ses_B PF17046.5 CRG89233.1 - 0.0015 18.4 0.4 0.0034 17.3 0.4 1.6 1 0 0 1 1 1 1 SesB domain on fungal death-pathway protein Cytochrom_D1 PF02239.16 CRG89233.1 - 0.0018 16.9 0.2 0.12 10.9 0.0 3.7 3 1 1 5 5 5 1 Cytochrome D1 heme domain CobA_CobO_BtuR PF02572.15 CRG89233.1 - 0.0038 17.5 0.0 0.0069 16.7 0.0 1.4 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP PALB2_WD40 PF16756.5 CRG89233.1 - 0.011 14.7 0.6 5 5.9 0.0 4.3 4 0 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain AAA_19 PF13245.6 CRG89233.1 - 0.019 15.3 0.0 0.042 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 CRG89233.1 - 0.074 12.3 0.1 0.26 10.5 0.1 1.7 1 1 0 1 1 1 0 KAP family P-loop domain HeLo PF14479.6 CRG89234.1 - 1e-30 107.1 3.5 1.5e-30 106.6 1.3 2.2 2 0 0 2 2 2 1 Prion-inhibition and propagation Goodbye PF17109.5 CRG89234.1 - 5.9e-14 52.6 7.7 7.7e-14 52.2 0.1 3.8 4 1 1 5 5 5 1 fungal STAND N-terminal Goodbye domain Ses_B PF17046.5 CRG89234.1 - 4e-06 26.7 7.0 4e-06 26.7 7.0 2.2 3 0 0 3 3 3 1 SesB domain on fungal death-pathway protein Gp-FAR-1 PF05823.12 CRG89234.1 - 0.035 14.5 3.9 9.8 6.5 0.2 3.4 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Lectin_N PF03954.14 CRG89234.1 - 0.11 12.2 4.5 0.19 11.5 0.5 2.6 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Noelin-1 PF12308.8 CRG89234.1 - 2.7 8.0 8.3 0.92 9.5 0.1 3.9 3 1 0 4 4 4 0 Neurogenesis glycoprotein Ses_B PF17046.5 CRG89235.1 - 7.4e-11 41.8 2.7 7.4e-11 41.8 2.7 1.6 2 0 0 2 2 2 1 SesB domain on fungal death-pathway protein DUF676 PF05057.14 CRG89235.1 - 5.4e-08 32.6 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CRG89235.1 - 1.5e-05 25.8 0.0 1.8e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 CRG89235.1 - 9.3e-05 22.2 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_9 PF10081.9 CRG89235.1 - 0.0024 17.0 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta-hydrolase family Tmemb_55A PF09788.9 CRG89236.1 - 0.064 12.3 0.4 0.073 12.1 0.4 1.1 1 0 0 1 1 1 0 Transmembrane protein 55A Methyltr_RsmB-F PF01189.17 CRG89237.1 - 1.1e-34 119.9 0.0 9.3e-27 94.0 0.0 3.3 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F ABC_tran_CTD PF16326.5 CRG89238.1 - 0.00027 21.1 1.5 0.00027 21.1 1.5 6.1 3 2 3 7 7 7 2 ABC transporter C-terminal domain EzrA PF06160.12 CRG89238.1 - 0.02 13.1 38.5 0.12 10.5 11.4 3.4 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA CorA PF01544.18 CRG89238.1 - 0.27 10.5 20.3 0.01 15.2 8.4 3.4 3 1 1 4 4 4 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.10 CRG89238.1 - 0.96 9.6 32.6 4.7 7.4 9.2 4.7 2 1 3 5 5 5 0 Fibrinogen alpha/beta chain family IL2 PF00715.17 CRG89238.1 - 0.97 9.4 3.8 1.8 8.5 3.2 1.8 1 1 0 1 1 1 0 Interleukin 2 Zw10 PF06248.13 CRG89238.1 - 3.3 6.2 18.7 0.017 13.7 7.2 2.3 2 1 0 2 2 2 0 Centromere/kinetochore Zw10 Apis_Csd PF11671.8 CRG89238.1 - 3.6 7.6 11.7 1.5 8.9 4.2 2.5 2 0 0 2 2 2 0 Complementary sex determiner protein APG6_N PF17675.1 CRG89238.1 - 8.2 7.0 64.7 1.4 9.5 15.3 4.8 2 1 3 5 5 5 0 Apg6 coiled-coil region RNA_pol_Rpb5_C PF01191.19 CRG89239.1 - 9.7e-33 111.9 0.1 1.9e-32 110.9 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 CRG89239.1 - 9.1e-26 90.3 0.0 1.4e-25 89.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 CRG89239.1 - 0.00056 19.9 0.0 0.0012 18.8 0.0 1.7 1 0 0 1 1 1 1 Restriction endonuclease Amidohydro_2 PF04909.14 CRG89241.1 - 4.6e-17 62.7 0.3 6.9e-17 62.2 0.3 1.3 1 1 0 1 1 1 1 Amidohydrolase Cutinase PF01083.22 CRG89243.1 - 7.7e-30 104.2 0.2 3.4e-28 98.8 0.1 2.2 2 0 0 2 2 2 2 Cutinase PE-PPE PF08237.11 CRG89243.1 - 0.00021 20.9 0.2 0.00034 20.2 0.2 1.3 1 0 0 1 1 1 1 PE-PPE domain Fungal_trans_2 PF11951.8 CRG89244.1 - 4.4e-43 147.5 0.9 6.8e-43 146.9 0.9 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89244.1 - 2.6e-07 30.6 4.8 5e-07 29.7 4.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 CRG89245.1 - 5.6e-30 104.6 0.0 7.4e-30 104.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG89245.1 - 2.2e-06 28.1 0.3 0.00012 22.6 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG89245.1 - 0.00055 20.0 0.1 0.2 11.6 0.0 3.6 3 1 1 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 CRG89245.1 - 0.072 12.7 0.6 9.2 5.7 0.1 2.8 2 1 0 3 3 3 0 FAD dependent oxidoreductase Fer4_14 PF13394.6 CRG89245.1 - 0.08 13.1 0.2 0.2 11.8 0.2 1.6 1 1 0 1 1 1 0 4Fe-4S single cluster domain Pyr_redox_3 PF13738.6 CRG89245.1 - 0.095 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyco_hydro_28 PF00295.17 CRG89246.1 - 6e-19 68.3 1.1 8.6e-19 67.8 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CRG89246.1 - 0.0008 19.3 14.9 0.0021 17.9 11.4 3.0 1 1 1 2 2 2 1 Pectate lyase superfamily protein BfiI_DBD PF18243.1 CRG89246.1 - 0.088 12.4 1.3 3.2 7.3 0.4 2.3 2 0 0 2 2 2 0 Metal-independent restriction enzyme BfiI DNA binding domain Aldo_ket_red PF00248.21 CRG89247.1 - 1.7e-47 162.1 0.0 6.1e-36 124.1 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Abhydrolase_1 PF00561.20 CRG89248.1 - 1.9e-20 73.6 0.2 1.3e-18 67.6 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG89248.1 - 3.5e-14 52.6 0.0 4e-13 49.2 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG89248.1 - 4.4e-14 53.6 0.2 5.8e-14 53.2 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CRG89248.1 - 0.00081 18.9 0.0 1.1 8.6 0.0 2.4 3 0 0 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_4 PF08386.10 CRG89248.1 - 0.0012 18.9 0.0 0.0021 18.2 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_5 PF12695.7 CRG89248.1 - 0.0015 18.3 0.0 0.081 12.7 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 CRG89248.1 - 0.0044 16.7 0.0 0.0066 16.1 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 CRG89248.1 - 0.0095 15.6 0.1 0.06 12.9 0.1 2.2 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 CRG89248.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Ndr PF03096.14 CRG89248.1 - 0.2 10.3 0.0 0.58 8.8 0.0 1.7 2 0 0 2 2 2 0 Ndr family Dabb PF07876.12 CRG89249.1 - 1.5e-13 51.1 0.0 1.7e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain p450 PF00067.22 CRG89250.1 - 1e-10 41.0 0.0 1.4e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CRG89251.1 - 1e-41 143.2 0.0 1.1e-41 143.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SLATT_fungal PF18142.1 CRG89252.1 - 9e-33 112.8 1.2 1.8e-32 111.8 0.1 2.0 2 0 0 2 2 2 1 SMODS and SLOG-associating 2TM effector domain DUF883 PF05957.13 CRG89252.1 - 0.0004 20.9 8.7 0.057 14.0 0.3 3.7 1 1 3 4 4 4 3 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 CRG89252.1 - 0.0019 18.1 6.1 0.0019 18.1 6.1 1.7 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain ApoO PF09769.9 CRG89252.1 - 0.045 13.7 1.0 5.4 7.0 0.0 3.6 1 1 2 3 3 3 0 Apolipoprotein O YtxH PF12732.7 CRG89252.1 - 0.12 12.9 0.0 5.4 7.6 0.0 3.1 1 1 1 2 2 2 0 YtxH-like protein DUF2855 PF11017.8 CRG89254.1 - 1.7e-88 297.6 0.0 2e-88 297.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) Glyco_hydro_35 PF01301.19 CRG89256.1 - 3.1e-93 312.8 0.0 5.6e-93 312.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom2 PF10435.9 CRG89256.1 - 2.4e-64 216.5 7.8 2.4e-64 216.5 7.8 1.9 2 0 0 2 2 2 1 Beta-galactosidase, domain 2 BetaGal_dom4_5 PF13364.6 CRG89256.1 - 6.8e-62 207.1 12.4 5.3e-35 120.4 0.2 3.5 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom3 PF13363.6 CRG89256.1 - 1.2e-22 79.3 0.5 4.2e-22 77.5 0.2 2.1 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 DUF4183 PF13799.6 CRG89256.1 - 0.086 12.7 3.7 0.24 11.2 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4183) CYSTM PF12734.7 CRG89257.1 - 9.9 6.6 58.3 1.8e+04 -14.1 58.3 5.2 1 1 0 1 1 1 0 Cysteine-rich TM module stress tolerance Syndecan PF01034.20 CRG89258.1 - 0.059 13.3 4.0 0.12 12.3 4.0 1.4 1 0 0 1 1 1 0 Syndecan domain Zot PF05707.12 CRG89260.1 - 0.001 18.7 0.1 0.0033 17.1 0.0 1.9 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_22 PF13401.6 CRG89260.1 - 0.011 16.0 0.1 6.9 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 CRG89260.1 - 0.17 11.9 0.0 0.17 11.9 0.0 2.7 3 0 0 3 3 3 0 Helicase HerA, central domain DUF2884 PF11101.8 CRG89261.1 - 0.094 12.2 0.0 0.21 11.1 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) Abhydrolase_2 PF02230.16 CRG89262.1 - 1.3e-15 57.8 0.0 7.6e-15 55.3 0.0 2.0 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DEAD PF00270.29 CRG89263.1 - 4.9e-43 146.9 0.0 9.1e-43 146.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG89263.1 - 1.8e-20 73.4 0.0 1.5e-19 70.4 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG89263.1 - 0.00025 21.1 0.0 0.0004 20.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG89263.1 - 0.18 11.0 0.0 0.31 10.2 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Adenylsucc_synt PF00709.21 CRG89264.1 - 3e-168 560.1 0.0 3.4e-168 559.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase KHA PF11834.8 CRG89264.1 - 0.044 13.9 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 KHA, dimerisation domain of potassium ion channel DUF5320 PF17253.2 CRG89264.1 - 0.15 13.2 0.2 2.3 9.3 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DnaJ PF00226.31 CRG89265.1 - 1.9e-21 76.0 0.5 3.8e-21 75.0 0.5 1.6 1 0 0 1 1 1 1 DnaJ domain Fungal_trans PF04082.18 CRG89266.1 - 3.7e-25 88.5 0.0 8.6e-25 87.3 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89266.1 - 5.7e-09 35.9 12.3 9.2e-09 35.3 12.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tom5 PF10642.9 CRG89266.1 - 1.4 9.0 4.0 5.8 7.0 4.0 2.1 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase MFS_1 PF07690.16 CRG89267.1 - 5.7e-36 124.2 19.9 5.7e-36 124.2 19.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89267.1 - 2.1e-09 36.8 10.0 5.8e-09 35.3 10.0 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 CRG89267.1 - 0.00061 18.8 0.1 0.00061 18.8 0.1 3.6 1 1 2 3 3 3 2 MFS_1 like family DUF2198 PF09964.9 CRG89267.1 - 0.057 13.5 1.4 14 5.8 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2198) GTP1_OBG PF01018.22 CRG89268.1 - 1.9e-40 138.0 2.3 1.1e-30 106.3 3.7 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 CRG89268.1 - 6e-22 77.9 0.0 1e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG89268.1 - 1.8e-07 30.8 0.1 3.3e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 CRG89268.1 - 0.028 13.4 0.0 0.38 9.7 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 CRG89268.1 - 0.1 12.1 0.0 12 5.3 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 CRG89268.1 - 0.11 13.0 0.8 0.26 11.8 0.0 1.9 2 0 0 2 2 2 0 ABC transporter FMN_red PF03358.15 CRG89268.1 - 0.19 11.5 0.0 0.52 10.0 0.0 1.7 2 1 0 2 2 2 0 NADPH-dependent FMN reductase Cupin_8 PF13621.6 CRG89269.1 - 6.1e-30 104.8 0.0 2.1e-29 103.0 0.0 1.8 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 CRG89269.1 - 9.5e-07 28.6 0.0 0.0015 18.1 0.0 2.3 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 CRG89269.1 - 0.014 15.8 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 JmjC domain, hydroxylase Ccdc124 PF06244.12 CRG89270.1 - 1.1e-25 90.7 22.3 1.1e-25 90.7 22.3 2.4 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 WD40 PF00400.32 CRG89271.1 - 3.4e-15 56.2 12.4 0.022 15.7 0.4 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat 2OG-FeII_Oxy_2 PF13532.6 CRG89272.1 - 1.9e-40 139.2 0.4 2.7e-40 138.7 0.4 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 CRG89272.1 - 1.3e-05 25.2 4.3 2.7e-05 24.1 4.3 1.6 1 0 0 1 1 1 1 GRF zinc finger CUE PF02845.16 CRG89272.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 CUE domain DUF4355 PF14265.6 CRG89272.1 - 0.036 14.3 2.1 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) UQ_con PF00179.26 CRG89273.1 - 3.3e-10 39.7 0.0 6.4e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TMEM132 PF16070.5 CRG89273.1 - 0.22 10.8 0.3 0.42 9.9 0.1 1.5 2 0 0 2 2 2 0 Transmembrane protein family 132 Aldedh PF00171.22 CRG89275.1 - 2.2e-184 613.3 0.4 2.6e-184 613.1 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LPD38 PF18857.1 CRG89275.1 - 0.023 14.8 0.0 2.3 8.3 0.0 2.4 2 0 0 2 2 2 0 Large polyvalent protein associated domain 38 Wtap PF17098.5 CRG89275.1 - 0.24 11.3 0.0 0.63 10.0 0.0 1.6 2 0 0 2 2 2 0 WTAP/Mum2p family Homeobox_KN PF05920.11 CRG89276.1 - 4.2e-16 58.6 8.2 6.7e-16 57.9 0.3 3.7 3 0 0 3 3 3 1 Homeobox KN domain zf-C2H2 PF00096.26 CRG89276.1 - 1.9e-05 24.8 13.4 0.19 12.2 0.9 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type Homeodomain PF00046.29 CRG89276.1 - 0.00018 21.3 0.1 0.00045 20.0 0.1 1.8 1 0 0 1 1 1 1 Homeodomain zf-C2H2_4 PF13894.6 CRG89276.1 - 0.0075 17.0 1.1 0.0075 17.0 1.1 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 CRG89276.1 - 0.12 13.0 4.6 5.4 7.7 0.1 2.5 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats AAA_13 PF13166.6 CRG89276.1 - 0.98 8.0 7.5 0.46 9.1 2.1 2.1 1 1 1 2 2 2 0 AAA domain NmrA PF05368.13 CRG89277.1 - 5.5e-25 88.3 0.0 6.6e-25 88.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 CRG89277.1 - 0.0067 16.7 0.0 0.02 15.1 0.0 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CRG89277.1 - 0.045 14.0 0.0 0.096 13.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain GFO_IDH_MocA PF01408.22 CRG89278.1 - 4.3e-16 59.8 0.0 9.2e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG89278.1 - 0.1 13.3 0.1 0.17 12.5 0.1 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain OTT_1508_deam PF14441.6 CRG89280.1 - 1.1e-16 60.6 0.4 2.3e-16 59.5 0.4 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase F-box-like PF12937.7 CRG89281.1 - 1.5e-05 24.8 0.1 3.5e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 F-box-like Peptidase_C13 PF01650.18 CRG89282.1 - 2.5e-40 138.6 0.0 3.2e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family CDC45 PF02724.14 CRG89283.1 - 1.9e-242 806.2 5.0 2.9e-241 802.3 5.0 2.9 1 1 0 1 1 1 1 CDC45-like protein Cwf_Cwc_15 PF04889.12 CRG89283.1 - 0.00035 20.4 7.0 0.00035 20.4 7.0 2.3 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 CRG89283.1 - 0.013 14.9 27.8 0.025 13.9 10.0 2.3 2 0 0 2 2 2 0 BUD22 CNDH2_C PF16858.5 CRG89283.1 - 0.27 11.1 9.8 0.027 14.4 1.3 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SDA1 PF05285.12 CRG89283.1 - 0.98 8.8 24.7 1.3 8.4 7.8 2.3 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 CRG89283.1 - 2.5 6.2 27.6 0.066 11.4 7.5 2.1 2 0 0 2 2 2 0 Nop14-like family FAM60A PF15396.6 CRG89283.1 - 5.3 7.0 7.1 0.48 10.4 0.8 2.1 2 0 0 2 2 2 0 Protein Family FAM60A RR_TM4-6 PF06459.12 CRG89283.1 - 5.5 6.7 10.5 0.7 9.7 3.5 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PNISR PF15996.5 CRG89283.1 - 6.3 7.0 20.8 4.7 7.4 10.2 2.3 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Glyco_hydro_47 PF01532.20 CRG89284.1 - 2.1e-134 448.9 0.2 2.4e-134 448.7 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Acetyltransf_3 PF13302.7 CRG89285.1 - 2.8e-08 34.5 0.0 4.3e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG89285.1 - 9.2e-08 32.3 0.0 1.4e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG89285.1 - 0.092 13.2 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Histidinol_dh PF00815.20 CRG89287.1 - 4.4e-161 536.5 4.7 7.5e-161 535.7 4.7 1.4 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 CRG89287.1 - 1.8e-24 85.3 0.5 4e-24 84.2 0.5 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 CRG89287.1 - 2.3e-14 53.6 0.3 6.6e-14 52.1 0.3 1.9 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MID_pPIWI_RE PF18157.1 CRG89288.1 - 0.2 11.9 0.0 0.28 11.5 0.0 1.2 1 0 0 1 1 1 0 MID domain of pPIWI_RE ACC_epsilon PF13822.6 CRG89289.1 - 0.34 11.6 3.1 0.51 11.0 3.1 1.3 1 0 0 1 1 1 0 Acyl-CoA carboxylase epsilon subunit Utp11 PF03998.13 CRG89290.1 - 2.7e-59 201.1 31.3 3.8e-59 200.6 31.3 1.2 1 0 0 1 1 1 1 Utp11 protein Nop53 PF07767.11 CRG89290.1 - 0.0011 18.4 22.7 0.0011 18.4 22.7 2.0 2 0 0 2 2 2 1 Nop53 (60S ribosomal biogenesis) DUF4611 PF15387.6 CRG89290.1 - 0.18 12.0 17.8 0.48 10.7 17.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) Cmc1 PF08583.10 CRG89291.1 - 1.6e-16 60.0 2.4 1.6e-16 60.0 2.4 1.6 1 1 1 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 CRG89291.1 - 0.00035 20.2 1.7 0.00054 19.6 1.7 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CHCH PF06747.13 CRG89291.1 - 0.00045 20.3 0.7 0.00074 19.6 0.7 1.4 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 CRG89291.1 - 0.006 16.6 0.1 0.011 15.8 0.1 1.4 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, GCK PF07802.11 CRG89291.1 - 0.016 15.6 0.3 0.016 15.6 0.3 1.8 2 0 0 2 2 2 0 GCK domain COX17 PF05051.13 CRG89291.1 - 0.091 13.1 1.2 6.5 7.2 0.1 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF3128 PF11326.8 CRG89291.1 - 1.9 8.9 7.3 42 4.6 7.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) TFIID-31kDa PF02291.15 CRG89292.1 - 2.9e-44 150.1 0.0 3.8e-44 149.6 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit LNS2 PF08235.13 CRG89293.1 - 4.7e-98 327.2 0.0 6.5e-98 326.7 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 CRG89293.1 - 1.2e-42 144.0 0.0 6e-42 141.8 0.0 2.1 2 0 0 2 2 2 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 CRG89293.1 - 0.0031 17.2 0.1 0.25 10.9 0.0 2.5 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) WRNPLPNID PF15017.6 CRG89293.1 - 3.6 8.5 13.4 13 6.8 13.4 2.0 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Thg1C PF14413.6 CRG89294.1 - 8.4e-52 174.5 1.2 8.4e-52 174.5 1.2 3.7 3 1 0 3 3 3 1 Thg1 C terminal domain Thg1 PF04446.12 CRG89294.1 - 1.7e-50 170.2 0.0 3.1e-50 169.4 0.0 1.5 1 0 0 1 1 1 1 tRNAHis guanylyltransferase fn3 PF00041.21 CRG89294.1 - 8.9e-06 26.0 0.0 8.9e-06 26.0 0.0 2.6 3 0 0 3 3 3 1 Fibronectin type III domain ALIX_LYPXL_bnd PF13949.6 CRG89294.1 - 0.0015 17.9 30.5 0.0051 16.2 30.5 1.9 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV LZ3wCH PF18517.1 CRG89294.1 - 2.7 8.2 6.3 26 5.0 1.7 2.9 2 0 0 2 2 2 0 Leucine zipper with capping helix domain DUF3584 PF12128.8 CRG89294.1 - 8.9 3.7 46.2 1.3e+02 -0.2 46.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) WD40 PF00400.32 CRG89296.1 - 2.6e-15 56.5 0.0 0.0094 16.8 0.0 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG89296.1 - 0.00082 19.6 0.1 10 6.5 0.0 4.0 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CRG89296.1 - 0.017 13.9 0.0 0.15 10.7 0.0 2.1 2 0 0 2 2 2 0 Nup133 N terminal like Methyltransf_23 PF13489.6 CRG89297.1 - 1.5e-14 54.2 0.0 3.1e-14 53.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89297.1 - 1.9e-07 31.7 0.0 9e-07 29.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89297.1 - 6e-06 26.9 0.0 2.1e-05 25.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89297.1 - 9.2e-05 23.0 0.0 0.00032 21.3 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89297.1 - 0.00048 19.9 0.0 0.0014 18.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CRG89297.1 - 0.00054 19.5 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 CRG89297.1 - 0.0056 16.8 0.0 0.015 15.4 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 CRG89297.1 - 0.011 15.2 0.0 0.011 15.2 0.0 2.2 3 0 0 3 3 2 0 Putative methyltransferase PrmA PF06325.13 CRG89297.1 - 0.027 13.9 0.0 0.045 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CRG89297.1 - 0.081 12.7 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Ubie_methyltran PF01209.18 CRG89297.1 - 0.09 12.1 0.0 0.25 10.7 0.0 1.8 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ser_hydrolase PF06821.13 CRG89297.1 - 0.097 12.5 0.2 0.16 11.9 0.2 1.2 1 0 0 1 1 1 0 Serine hydrolase Methyltransf_2 PF00891.18 CRG89297.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase domain WD40 PF00400.32 CRG89298.1 - 8.2e-16 58.1 4.8 3.9e-06 27.5 0.2 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG89298.1 - 2.9e-11 43.5 0.4 1.1e-05 25.6 0.0 4.6 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CRG89298.1 - 0.046 12.3 0.0 0.27 9.7 0.0 2.1 2 1 0 2 2 2 0 Cytochrome D1 heme domain RNA_pol_Rpb1_1 PF04997.12 CRG89299.1 - 4.3e-109 364.6 0.0 6.8e-109 364.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 CRG89299.1 - 1.1e-104 349.6 0.3 1.7e-104 349.0 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CRG89299.1 - 3.3e-73 245.4 0.1 9.4e-73 243.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 CRG89299.1 - 2.5e-63 213.4 1.7 6.1e-63 212.1 1.7 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 CRG89299.1 - 3.4e-48 163.5 0.0 8e-48 162.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 CRG89299.1 - 4.9e-45 152.8 6.9 1.5e-44 151.2 6.9 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 CRG89299.1 - 2.7e-36 123.8 0.2 9.1e-36 122.1 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Sel1 PF08238.12 CRG89299.1 - 3.9e-27 94.1 31.9 5.4e-05 23.7 0.8 10.1 10 0 0 10 10 10 6 Sel1 repeat RNA_pol_Rpb1_R PF05001.13 CRG89299.1 - 5.2e-09 36.0 181.2 0.039 14.3 1.1 13.8 12 2 2 14 14 13 10 RNA polymerase Rpb1 C-terminal repeat TPR_7 PF13176.6 CRG89299.1 - 0.037 14.1 1.6 41 4.5 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Snapin_Pallidin PF14712.6 CRG89299.1 - 0.31 11.5 1.6 1 9.8 1.6 1.9 1 0 0 1 1 1 0 Snapin/Pallidin TPR_1 PF00515.28 CRG89299.1 - 1.5 8.8 7.1 4.6 7.2 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SMBP PF16785.5 CRG89299.1 - 3.1 8.1 8.2 14 6.0 0.0 3.5 4 0 0 4 4 2 0 Small metal-binding protein Mei5 PF10376.9 CRG89299.1 - 4.2 7.2 5.6 0.54 10.1 0.9 1.8 2 0 0 2 2 2 0 Double-strand recombination repair protein Glyco_hydro_1 PF00232.18 CRG89300.1 - 7.1e-147 489.5 0.1 8.2e-147 489.3 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 AID PF18767.1 CRG89300.1 - 0.032 14.2 0.0 0.65 10.0 0.0 2.4 2 0 0 2 2 2 0 Activation induced deaminase Kelch_4 PF13418.6 CRG89301.1 - 8e-25 86.6 9.9 3.5e-07 30.1 0.0 5.1 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.6 CRG89301.1 - 7.9e-24 83.2 0.8 0.00029 20.7 0.0 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 CRG89301.1 - 5.5e-23 80.4 3.7 2.4e-05 24.5 0.0 5.0 2 1 2 4 4 4 4 Kelch motif Kelch_2 PF07646.15 CRG89301.1 - 3.4e-20 71.2 2.1 2.2e-05 24.2 0.1 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 CRG89301.1 - 1.2e-19 70.1 9.4 7.6e-08 32.5 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 CRG89301.1 - 2.1e-15 56.0 0.2 0.00017 21.1 0.1 4.5 4 0 0 4 4 4 3 Kelch motif BTB PF00651.31 CRG89301.1 - 4.6e-09 36.5 0.1 7.8e-09 35.8 0.1 1.3 1 0 0 1 1 1 1 BTB/POZ domain TFIIA PF03153.13 CRG89302.1 - 4.6e-85 287.1 0.3 1.1e-84 285.9 0.3 1.7 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit ANAPC4_WD40 PF12894.7 CRG89302.1 - 4.3e-15 55.8 3.3 2e-05 24.8 0.1 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG89302.1 - 7.3e-13 48.8 18.9 0.00066 20.4 0.1 6.4 6 1 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CRG89302.1 - 8.7e-05 21.6 0.0 0.0032 16.5 0.0 2.8 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CRG89302.1 - 0.0011 18.9 0.3 0.067 13.1 0.1 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Zn_clus PF00172.18 CRG89303.1 - 5.9e-11 42.3 6.7 1.4e-10 41.1 6.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UPF0239 PF06783.11 CRG89303.1 - 0.035 14.3 0.3 0.093 12.9 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) Fungal_trans PF04082.18 CRG89303.1 - 0.039 13.0 0.0 0.063 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain BBS2_C PF14782.6 CRG89303.1 - 0.13 11.0 0.0 0.21 10.3 0.0 1.3 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Arf PF00025.21 CRG89305.1 - 3.6e-45 153.5 0.2 4.1e-45 153.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 CRG89305.1 - 1.8e-13 50.4 1.2 2.6e-07 30.1 0.2 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CRG89305.1 - 9.9e-12 45.1 0.0 1.4e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CRG89305.1 - 3.6e-09 36.3 0.0 3.9e-09 36.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 CRG89305.1 - 6e-08 32.4 0.0 6.7e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 CRG89305.1 - 3.6e-07 30.2 0.0 4.8e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 CRG89305.1 - 4.3e-06 26.3 0.0 5.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit VGLL4 PF15245.6 CRG89305.1 - 0.034 14.2 0.0 0.045 13.8 0.0 1.1 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 FeoB_N PF02421.18 CRG89305.1 - 0.089 12.3 0.1 0.24 10.9 0.1 1.7 1 1 0 1 1 1 0 Ferrous iron transport protein B 6PF2K PF01591.18 CRG89305.1 - 0.17 11.2 0.1 0.37 10.1 0.0 1.5 1 1 1 2 2 2 0 6-phosphofructo-2-kinase DUF4045 PF13254.6 CRG89306.1 - 4.4e-124 415.3 41.7 4.4e-124 415.3 41.7 5.4 3 2 1 4 4 4 1 Domain of unknown function (DUF4045) Gelsolin PF00626.22 CRG89306.1 - 5.6e-10 39.0 0.0 0.0016 18.3 0.0 3.9 3 0 0 3 3 3 3 Gelsolin repeat ALO PF04030.14 CRG89307.1 - 3.1e-92 309.1 0.0 4.4e-92 308.6 0.0 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 CRG89307.1 - 2.9e-31 108.1 0.0 4.5e-31 107.4 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DnaJ PF00226.31 CRG89309.1 - 1.3e-16 60.5 0.8 3.6e-16 59.0 0.8 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 CRG89309.1 - 1.4e-09 37.5 0.0 7.7e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 Sec63 Brl domain Peptidase_M24 PF00557.24 CRG89311.1 - 8.6e-62 208.5 0.2 1.4e-61 207.8 0.1 1.4 2 0 0 2 2 2 1 Metallopeptidase family M24 AMP_N PF05195.16 CRG89311.1 - 7.9e-22 77.3 0.0 1.4e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain HTH_50 PF18024.1 CRG89311.1 - 0.054 13.1 0.5 0.41 10.3 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain Aldo_ket_red PF00248.21 CRG89312.1 - 6.5e-62 209.4 0.0 7.3e-62 209.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pox_E6 PF04656.12 CRG89313.1 - 0.15 10.5 0.1 0.32 9.4 0.0 1.5 2 0 0 2 2 2 0 Pox virus E6 protein SPRY PF00622.28 CRG89314.1 - 4.7e-18 65.4 0.0 7.1e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain PDEase_II PF02112.15 CRG89315.1 - 2e-57 194.9 0.0 6.7e-26 91.2 0.0 3.0 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II Lactamase_B PF00753.27 CRG89315.1 - 0.026 14.5 0.3 0.055 13.5 0.3 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG89315.1 - 0.027 14.0 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Amidase PF01425.21 CRG89316.1 - 2.8e-83 280.4 0.3 1.6e-82 277.9 0.3 1.9 1 1 0 1 1 1 1 Amidase GWT1 PF06423.12 CRG89317.1 - 1.1e-38 132.7 0.3 2.5e-38 131.5 0.3 1.7 1 0 0 1 1 1 1 GWT1 Fungal_trans PF04082.18 CRG89317.1 - 5.7e-08 32.1 0.0 9.5e-08 31.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89317.1 - 1.1e-07 31.8 8.7 2e-07 31.0 8.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF92 PF01940.16 CRG89317.1 - 0.016 14.6 1.3 0.041 13.3 0.5 2.0 1 1 0 1 1 1 0 Integral membrane protein DUF92 Mito_fiss_reg PF05308.11 CRG89318.1 - 1.9e-05 24.9 7.0 1.9e-05 24.9 7.0 3.0 1 1 1 3 3 3 1 Mitochondrial fission regulator bZIP_1 PF00170.21 CRG89318.1 - 0.00039 20.5 6.2 0.00039 20.5 6.2 2.1 1 1 1 2 2 2 1 bZIP transcription factor YabA PF06156.13 CRG89318.1 - 0.0028 18.3 0.3 0.007 17.0 0.3 1.6 1 0 0 1 1 1 1 Initiation control protein YabA ASD2 PF08687.11 CRG89318.1 - 0.006 16.2 5.1 0.0091 15.6 5.1 1.2 1 0 0 1 1 1 1 Apx/Shroom domain ASD2 bZIP_2 PF07716.15 CRG89318.1 - 0.012 15.7 9.4 0.012 15.7 9.4 2.7 3 1 1 4 4 4 0 Basic region leucine zipper VSG_B PF13206.6 CRG89318.1 - 0.44 9.7 3.8 0.62 9.3 3.8 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain BMFP PF04380.13 CRG89318.1 - 1.3 9.6 9.1 0.39 11.2 3.5 2.3 2 0 0 2 2 2 0 Membrane fusogenic activity DivIC PF04977.15 CRG89318.1 - 1.7 8.5 4.7 1.1 9.1 2.0 2.0 1 1 1 2 2 2 0 Septum formation initiator DUF2937 PF11157.8 CRG89318.1 - 1.9 8.2 4.1 2.6 7.8 3.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) zf-C4H2 PF10146.9 CRG89318.1 - 9.9 6.4 12.5 18 5.5 11.7 1.9 1 1 0 1 1 1 0 Zinc finger-containing protein Acyl-CoA_dh_1 PF00441.24 CRG89319.1 - 1.7e-38 132.1 8.3 4.7e-38 130.7 8.3 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 CRG89319.1 - 4e-31 108.0 0.3 4e-31 108.0 0.3 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 CRG89319.1 - 4.4e-25 87.7 0.0 1.4e-24 86.1 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 CRG89319.1 - 1.2e-14 54.7 3.4 1.2e-14 54.7 3.4 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CRG89319.1 - 0.0024 17.6 0.0 0.0066 16.1 0.0 1.7 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal MYT1 PF08474.11 CRG89319.1 - 0.082 12.8 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Myelin transcription factor 1 Zn_clus PF00172.18 CRG89320.1 - 6.5e-09 35.8 10.3 1.2e-08 34.9 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG89320.1 - 0.00018 20.5 1.2 0.00031 19.7 1.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Senescence PF06911.12 CRG89321.1 - 1.8e-53 181.6 8.5 2.6e-53 181.1 8.5 1.2 1 0 0 1 1 1 1 Senescence-associated protein DUF3082 PF11282.8 CRG89321.1 - 0.022 15.0 0.1 0.048 13.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3082) Pkinase PF00069.25 CRG89322.1 - 2.1e-63 214.2 0.0 3.4e-63 213.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89322.1 - 1.6e-35 122.7 0.0 6.3e-30 104.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CRG89322.1 - 3.5e-07 29.8 0.1 0.00056 19.3 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 CRG89322.1 - 0.00039 20.4 0.1 0.002 18.1 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 CRG89322.1 - 0.043 12.8 0.1 0.043 12.8 0.1 1.6 2 0 0 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 CRG89322.1 - 0.064 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Bap31 PF05529.12 CRG89323.1 - 3.3e-47 159.7 7.4 4.7e-47 159.2 7.4 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 CRG89323.1 - 2.3e-16 59.5 3.2 4.2e-16 58.7 3.2 1.5 1 0 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DivIC PF04977.15 CRG89323.1 - 0.11 12.3 0.5 0.11 12.3 0.5 3.0 3 0 0 3 3 3 0 Septum formation initiator Geminin PF07412.12 CRG89323.1 - 0.13 12.0 1.3 0.34 10.6 0.6 1.8 2 0 0 2 2 2 0 Geminin CAMSAP_CC1 PF17095.5 CRG89323.1 - 0.15 12.0 1.7 1.8 8.5 0.4 2.4 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin Spc7 PF08317.11 CRG89323.1 - 0.2 10.5 0.7 0.27 10.1 0.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Dus PF01207.17 CRG89324.1 - 2.3e-41 141.9 0.0 6.2e-30 104.3 0.0 2.8 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) MMM1 PF10296.9 CRG89324.1 - 1.3e-06 27.7 0.0 5.6e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 zf-CCCH_4 PF18044.1 CRG89324.1 - 2.6e-06 27.1 6.7 7.5e-05 22.4 1.0 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 CRG89324.1 - 4.4e-05 23.4 8.1 0.025 14.6 1.0 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 CRG89324.1 - 7.1e-05 22.6 2.5 0.1 12.5 0.2 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 CRG89324.1 - 0.025 15.3 3.9 2.7 8.7 0.1 2.6 1 1 1 2 2 2 0 Torus domain zf-C2H2 PF00096.26 CRG89325.1 - 2.3e-05 24.6 10.1 0.086 13.3 1.5 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 CRG89325.1 - 0.00011 22.4 0.8 0.056 13.6 0.0 2.2 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 CRG89325.1 - 0.00021 21.9 11.4 0.037 14.9 1.1 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG89325.1 - 0.024 15.1 0.5 0.024 15.1 0.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 CRG89325.1 - 0.51 10.7 5.9 1.4 9.3 0.1 2.7 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF4719 PF15843.5 CRG89325.1 - 1.5 8.9 0.0 1.5 8.9 0.0 3.1 1 1 0 3 3 3 0 Domain of unknown function (DUF4719) zf-C2H2_6 PF13912.6 CRG89325.1 - 8.8 6.5 9.6 1.1 9.3 2.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger HMGL-like PF00682.19 CRG89326.1 - 7.2e-79 265.1 0.0 2.8e-78 263.1 0.0 1.9 2 0 0 2 2 2 1 HMGL-like DEAD PF00270.29 CRG89326.1 - 4.7e-48 163.3 0.0 1.2e-47 162.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG89326.1 - 4.9e-30 104.1 0.3 2.6e-28 98.6 0.2 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain LeuA_dimer PF08502.10 CRG89326.1 - 8.4e-21 74.3 0.0 2.1e-20 73.0 0.0 1.7 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain UTP25 PF06862.12 CRG89326.1 - 0.0014 17.5 1.1 0.0042 15.9 0.1 2.2 2 1 1 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AMP-binding PF00501.28 CRG89327.1 - 3.4e-67 226.9 1.9 4.4e-28 98.0 1.2 4.1 3 1 0 3 3 3 3 AMP-binding enzyme DMAP_binding PF06464.11 CRG89327.1 - 2.1e-08 35.0 0.0 9.6e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.12 CRG89327.1 - 0.12 12.4 0.1 0.26 11.3 0.1 1.6 1 0 0 1 1 1 0 Gas vesicle protein G Ribosomal_S7 PF00177.21 CRG89328.1 - 3.5e-35 120.9 3.6 4.4e-35 120.5 3.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e SDA1 PF05285.12 CRG89329.1 - 2.3e-92 310.1 64.5 2.5e-92 310.0 54.3 2.9 2 1 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 CRG89329.1 - 1.9e-24 85.7 0.1 5.1e-24 84.3 0.1 1.8 1 0 0 1 1 1 1 NUC130/3NT domain MFS_1 PF07690.16 CRG89330.1 - 1.9e-27 96.1 17.6 1.9e-27 96.1 17.6 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Glyco_hydro_2_N PF02837.18 CRG89330.1 - 1.5e-16 60.8 0.0 4.1e-16 59.3 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 CRG89330.1 - 1.6e-08 35.2 0.0 6e-08 33.3 0.0 2.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Sugar_tr PF00083.24 CRG89330.1 - 3.4e-06 26.2 4.8 0.011 14.6 0.0 2.5 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_3 PF05977.13 CRG89330.1 - 3.2e-05 22.5 4.1 5.2e-05 21.8 4.1 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector Glyco_hydro_2_C PF02836.17 CRG89330.1 - 0.00021 20.5 0.0 0.00074 18.7 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain OATP PF03137.20 CRG89330.1 - 0.003 15.9 3.3 0.011 14.1 2.4 2.1 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family BetaGal_dom4_5 PF13364.6 CRG89330.1 - 0.01 16.4 0.1 0.029 14.9 0.1 1.8 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain UNC-93 PF05978.16 CRG89330.1 - 0.16 11.7 6.6 0.11 12.2 2.4 2.2 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 MFS_1_like PF12832.7 CRG89330.1 - 1 8.1 15.0 0.045 12.6 7.4 2.3 3 1 1 4 4 4 0 MFS_1 like family MFS_1 PF07690.16 CRG89331.1 - 1.5e-26 93.2 43.8 1.5e-26 93.2 43.8 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily RNR_inhib PF08591.10 CRG89332.1 - 3.4e-24 86.2 0.5 7.7e-24 85.1 0.1 1.8 2 0 0 2 2 2 1 Ribonucleotide reductase inhibitor 2OG-FeII_Oxy PF03171.20 CRG89333.1 - 1.7e-14 54.1 0.1 3.5e-14 53.1 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG89333.1 - 1.2e-08 35.7 0.0 2.6e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Haem_oxygenas_2 PF14518.6 CRG89334.1 - 1.3e-37 129.3 0.0 2.6e-37 128.3 0.0 1.5 1 0 0 1 1 1 1 Iron-containing redox enzyme MFS_1 PF07690.16 CRG89335.1 - 4e-16 58.9 58.1 3.5e-14 52.5 30.8 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM238 PF15125.6 CRG89335.1 - 0.031 14.5 0.2 0.13 12.4 0.2 2.2 1 0 0 1 1 1 0 TMEM238 protein family DUF4267 PF14087.6 CRG89335.1 - 0.035 14.2 0.1 0.035 14.2 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4267) HSP70 PF00012.20 CRG89336.1 - 1.9e-61 208.0 4.5 7e-57 192.9 0.1 2.2 2 0 0 2 2 2 2 Hsp70 protein Tubulin_3 PF14881.6 CRG89337.1 - 6.2e-83 276.9 0.1 1.2e-82 275.9 0.1 1.5 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 CRG89337.1 - 5.2e-43 146.1 0.1 2.1e-42 144.2 0.0 2.1 3 0 0 3 3 3 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 CRG89337.1 - 4.4e-05 23.8 0.0 0.39 10.9 0.0 2.4 2 1 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain DinB_2 PF12867.7 CRG89338.1 - 0.067 13.7 1.0 0.36 11.4 0.1 2.4 2 0 0 2 2 2 0 DinB superfamily DUF2347 PF09804.9 CRG89339.1 - 3.3e-92 309.1 0.0 4.6e-89 298.8 0.0 2.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 CRG89339.1 - 6.6e-56 189.7 1.7 1.6e-55 188.4 1.7 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4484) Avl9 PF09794.9 CRG89339.1 - 7.3e-06 24.9 0.0 0.0015 17.3 0.0 2.4 2 1 0 2 2 2 2 Transport protein Avl9 SPA PF08616.10 CRG89339.1 - 1.8e-05 24.7 0.0 0.00011 22.1 0.0 2.1 2 0 0 2 2 2 1 Stabilization of polarity axis EBP PF05241.12 CRG89340.1 - 4.9e-46 156.4 5.2 6e-46 156.1 5.2 1.0 1 0 0 1 1 1 1 Emopamil binding protein SNF2_N PF00176.23 CRG89342.1 - 3e-56 190.6 0.0 4.8e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG89342.1 - 4.1e-14 52.9 0.0 9.1e-14 51.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG89342.1 - 1.9e-09 37.7 0.0 4.3e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 CRG89342.1 - 0.018 14.2 0.0 0.066 12.4 0.0 1.9 1 1 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 CRG89342.1 - 0.022 14.4 0.0 0.038 13.6 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase DUF2439 PF10382.9 CRG89342.1 - 0.29 11.5 0.9 1.7 9.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2439) AA_permease_2 PF13520.6 CRG89343.1 - 6.4e-47 160.3 50.0 8.2e-47 160.0 50.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG89343.1 - 3.2e-25 88.7 42.9 4.2e-25 88.3 42.9 1.0 1 0 0 1 1 1 1 Amino acid permease adh_short_C2 PF13561.6 CRG89345.1 - 4.6e-32 111.5 0.0 6.6e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89345.1 - 1.3e-24 86.8 0.0 2.2e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_deac_1 PF01522.21 CRG89345.1 - 5.9e-18 65.0 0.0 2.4e-17 63.0 0.0 2.0 2 0 0 2 2 2 1 Polysaccharide deacetylase DUF2334 PF10096.9 CRG89345.1 - 1.7e-06 27.8 0.0 4.9e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) NAD_binding_10 PF13460.6 CRG89345.1 - 1.2e-05 25.3 0.0 1.9e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG89345.1 - 0.0017 17.9 0.0 0.0035 16.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG89345.1 - 0.003 17.1 0.0 0.012 15.2 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family DFP PF04127.15 CRG89345.1 - 0.056 13.3 0.0 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein Polysacc_synt_2 PF02719.15 CRG89345.1 - 0.12 11.5 0.1 0.24 10.5 0.1 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein AAA_2 PF07724.14 CRG89346.1 - 5.4e-46 156.8 0.0 1.2e-44 152.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 CRG89346.1 - 2.2e-33 114.3 1.0 2.2e-33 114.3 1.0 4.2 3 1 1 4 4 4 1 AAA lid domain AAA PF00004.29 CRG89346.1 - 6.6e-26 91.3 0.0 1.4e-13 51.4 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CRG89346.1 - 3.3e-24 84.8 0.3 1.5e-23 82.7 0.3 2.3 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CRG89346.1 - 2.9e-15 56.5 0.1 5.2e-09 36.2 0.0 3.3 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CRG89346.1 - 6.6e-13 49.1 0.0 5.5e-05 23.5 0.0 4.5 2 1 1 3 3 3 2 AAA domain AAA_16 PF13191.6 CRG89346.1 - 6.8e-11 42.8 13.2 1.6e-06 28.6 0.1 5.5 5 2 0 5 5 4 2 AAA ATPase domain Sigma54_activat PF00158.26 CRG89346.1 - 7.9e-09 35.4 0.0 2.7e-05 24.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Clp_N PF02861.20 CRG89346.1 - 3e-07 30.4 1.4 0.0037 17.3 0.0 4.2 3 0 0 3 3 3 1 Clp amino terminal domain, pathogenicity island component AAA_18 PF13238.6 CRG89346.1 - 8.8e-07 29.5 0.6 0.02 15.4 0.0 3.8 4 1 0 4 4 2 2 AAA domain AAA_7 PF12775.7 CRG89346.1 - 2.4e-06 27.2 0.0 0.015 14.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 CRG89346.1 - 3.1e-06 27.1 0.0 0.083 12.6 0.0 3.2 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_14 PF13173.6 CRG89346.1 - 5.2e-06 26.5 0.0 0.18 11.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 CRG89346.1 - 1.4e-05 24.5 0.9 0.18 11.2 0.0 4.5 4 2 0 4 4 3 1 Bacterial TniB protein AAA_33 PF13671.6 CRG89346.1 - 1.8e-05 24.9 0.0 0.26 11.4 0.0 3.3 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 CRG89346.1 - 2e-05 24.1 0.0 0.18 11.1 0.0 3.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 CRG89346.1 - 6.5e-05 23.0 3.5 0.16 11.8 0.1 4.2 4 1 0 4 4 3 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 CRG89346.1 - 9e-05 22.8 2.5 0.64 10.2 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_30 PF13604.6 CRG89346.1 - 0.00013 21.8 0.0 0.72 9.5 0.0 3.0 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 CRG89346.1 - 0.00013 22.3 0.0 0.55 10.6 0.0 2.5 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 CRG89346.1 - 0.00017 21.6 0.0 0.22 11.5 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 CRG89346.1 - 0.00035 20.3 1.9 3.7 7.3 0.8 4.4 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_3 PF07726.11 CRG89346.1 - 0.00044 20.1 0.0 1.1 9.1 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 CRG89346.1 - 0.00055 20.5 0.3 0.55 10.7 0.0 3.3 3 0 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 CRG89346.1 - 0.00055 19.9 0.1 1 9.3 0.0 2.9 3 0 0 3 3 2 1 RsgA GTPase AAA_19 PF13245.6 CRG89346.1 - 0.00061 20.1 0.1 0.3 11.4 0.1 3.2 2 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 CRG89346.1 - 0.0011 18.8 0.0 0.99 9.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 CRG89346.1 - 0.0011 19.5 10.1 0.37 11.3 0.0 4.0 4 1 0 4 4 3 1 AAA domain T2SSE PF00437.20 CRG89346.1 - 0.0016 17.6 0.0 0.025 13.6 0.0 2.5 2 1 0 2 2 2 1 Type II/IV secretion system protein AAA_29 PF13555.6 CRG89346.1 - 0.002 17.8 0.0 2.2 8.1 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain Torsin PF06309.11 CRG89346.1 - 0.004 17.3 0.0 0.015 15.4 0.0 1.9 3 0 0 3 3 1 1 Torsin Roc PF08477.13 CRG89346.1 - 0.0055 16.9 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 CRG89346.1 - 0.0062 16.5 0.0 0.55 10.1 0.0 2.9 3 0 0 3 3 2 1 NACHT domain Rad17 PF03215.15 CRG89346.1 - 0.013 15.4 0.0 6.9 6.5 0.0 2.8 2 1 0 2 2 2 0 Rad17 P-loop domain ResIII PF04851.15 CRG89346.1 - 0.015 15.3 0.0 1.3 9.0 0.0 3.3 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 CRG89346.1 - 0.019 14.9 0.0 0.49 10.3 0.0 2.9 3 0 0 3 3 2 0 NTPase Zeta_toxin PF06414.12 CRG89346.1 - 0.02 14.2 0.0 1.4 8.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 CRG89346.1 - 0.041 13.4 6.3 0.31 10.6 0.0 3.7 4 0 0 4 4 3 0 AAA domain SRP54 PF00448.22 CRG89346.1 - 0.046 13.4 0.0 8.2 6.0 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MPS2 PF17060.5 CRG89346.1 - 0.12 11.7 2.1 0.2 10.9 2.1 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 PIF1 PF05970.14 CRG89346.1 - 0.14 11.3 0.0 0.96 8.5 0.0 2.3 3 0 0 3 3 3 0 PIF1-like helicase V_ATPase_I PF01496.19 CRG89346.1 - 0.34 8.8 3.0 0.5 8.2 3.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Macoilin PF09726.9 CRG89346.1 - 0.49 8.9 5.0 0.81 8.2 5.0 1.3 1 0 0 1 1 1 0 Macoilin family YlqD PF11068.8 CRG89346.1 - 2.7 8.4 11.5 0.36 11.2 5.5 2.7 3 0 0 3 3 1 0 YlqD protein Sulfotransfer_3 PF13469.6 CRG89347.1 - 0.11 12.9 0.0 16 5.8 0.0 3.2 3 0 0 3 3 3 0 Sulfotransferase family ATG27 PF09451.10 CRG89348.1 - 1.6e-84 283.9 0.0 1.8e-84 283.7 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 CRG89348.1 - 1.7e-05 24.9 0.0 0.0026 17.9 0.0 2.8 3 0 0 3 3 3 1 Cation-independent mannose-6-phosphate receptor repeat Vfa1 PF08432.10 CRG89348.1 - 0.078 13.3 4.3 0.12 12.6 4.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SDA1 PF05285.12 CRG89348.1 - 0.7 9.3 14.1 0.95 8.8 14.1 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 CRG89348.1 - 1.1 7.4 9.7 1.5 7.0 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 CRG89348.1 - 2.9 6.4 19.1 4.3 5.8 19.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 CRG89348.1 - 4.5 5.4 18.5 5.6 5.0 18.5 1.0 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 CRG89348.1 - 5.1 5.5 10.7 6.5 5.2 10.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Prefoldin_2 PF01920.20 CRG89349.1 - 6.2e-24 84.0 4.3 7.4e-24 83.7 4.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit AKNA PF12443.8 CRG89349.1 - 0.013 16.2 1.9 0.051 14.2 0.0 2.1 1 1 1 2 2 2 0 AT-hook-containing transcription factor PEP-utilisers_N PF05524.13 CRG89349.1 - 0.02 15.1 0.1 0.02 15.1 0.1 2.0 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal DUF3338 PF11819.8 CRG89349.1 - 0.059 13.4 4.4 1.2 9.1 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3338) PP2C_2 PF13672.6 CRG89349.1 - 0.068 12.8 0.1 0.077 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C CENP-F_leu_zip PF10473.9 CRG89349.1 - 0.088 12.8 0.4 0.088 12.8 0.4 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.17 CRG89349.1 - 0.093 12.7 0.2 0.093 12.7 0.2 2.0 1 1 1 2 2 2 0 Prefoldin subunit LPP PF04728.13 CRG89349.1 - 0.11 12.9 2.2 1.8 9.1 0.0 2.3 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Spc7 PF08317.11 CRG89349.1 - 0.32 9.8 7.6 0.42 9.4 0.1 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 CRG89349.1 - 0.4 10.9 7.7 0.99 9.7 0.0 2.3 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.11 CRG89349.1 - 0.92 9.8 6.6 1.3 9.3 0.2 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.15 CRG89349.1 - 6.1 6.7 10.3 8.7 6.2 0.3 2.2 2 0 0 2 2 2 0 Septum formation initiator Fungal_trans PF04082.18 CRG89350.1 - 5e-24 84.8 0.1 8e-24 84.1 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89350.1 - 4.1e-05 23.6 15.6 0.00013 22.0 15.6 1.8 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta-lactamase PF00144.24 CRG89351.1 - 1.9e-30 106.2 1.4 2.7e-30 105.8 1.4 1.2 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 CRG89351.1 - 0.0057 16.3 0.1 2 8.0 0.0 2.8 2 1 1 3 3 3 2 Beta-lactamase enzyme family Soyouz_module PF14313.6 CRG89351.1 - 0.14 12.0 0.0 0.38 10.6 0.0 1.7 1 0 0 1 1 1 0 N-terminal region of Paramyxovirinae phosphoprotein (P) PAC4 PF16093.5 CRG89352.1 - 1e-28 99.3 0.4 1.4e-28 98.9 0.4 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 N2227 PF07942.12 CRG89353.1 - 3.7e-88 295.2 0.0 4.5e-88 295.0 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 CRG89353.1 - 0.0055 16.5 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89353.1 - 0.0083 16.8 0.0 0.029 15.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89353.1 - 0.042 14.6 0.0 0.36 11.6 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain 3Beta_HSD PF01073.19 CRG89354.1 - 4.6e-47 160.3 0.0 5.8e-47 160.0 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG89354.1 - 2.6e-22 79.5 0.0 3.3e-22 79.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG89354.1 - 3.1e-12 46.2 0.0 1.3e-07 31.1 0.0 2.1 1 1 1 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG89354.1 - 3.2e-11 43.2 0.0 1.4e-08 34.6 0.0 2.2 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG89354.1 - 4.5e-05 23.4 0.0 6.3e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CRG89354.1 - 0.00024 20.3 0.0 0.00038 19.7 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CRG89354.1 - 0.0011 18.2 0.1 0.0044 16.2 0.3 1.9 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein AA_permease PF00324.21 CRG89356.1 - 5.7e-103 345.1 44.5 6.5e-103 344.9 44.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG89356.1 - 1.5e-20 73.4 48.8 2e-20 73.1 48.8 1.0 1 0 0 1 1 1 1 Amino acid permease PgaD PF13994.6 CRG89356.1 - 0.75 9.8 5.6 0.86 9.6 0.1 2.5 2 0 0 2 2 2 0 PgaD-like protein adh_short PF00106.25 CRG89357.1 - 2.1e-31 108.9 1.4 2.9e-31 108.4 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89357.1 - 6.8e-22 78.2 2.6 2.8e-21 76.2 2.6 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89357.1 - 5.9e-17 62.2 1.0 8.5e-17 61.6 1.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG89357.1 - 1.2e-07 31.2 0.4 1.6e-07 30.8 0.4 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CRG89357.1 - 0.00042 19.9 0.4 0.0007 19.1 0.4 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Pyr_redox PF00070.27 CRG89357.1 - 0.09 13.3 0.1 0.22 12.1 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HSP70 PF00012.20 CRG89358.1 - 1.4e-10 40.1 0.2 3.8e-09 35.3 0.1 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 CRG89358.1 - 0.077 11.8 0.2 0.26 10.1 0.0 1.7 2 0 0 2 2 2 0 MreB/Mbl protein Fungal_trans PF04082.18 CRG89359.1 - 1.3e-13 50.6 0.0 3.3e-13 49.3 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89359.1 - 1e-07 32.0 10.4 2e-07 31.0 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 CRG89359.1 - 0.0061 16.3 0.4 0.02 14.6 0.4 1.9 1 0 0 1 1 1 1 Integrin plexin domain adh_short PF00106.25 CRG89360.1 - 2.4e-50 170.7 0.0 3.1e-50 170.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89360.1 - 3.8e-37 128.1 0.0 5.2e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89360.1 - 1.8e-11 44.3 0.0 2.6e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG89360.1 - 4.5e-05 23.4 0.1 6.8e-05 22.8 0.1 1.4 1 1 0 1 1 1 1 NAD(P)H-binding ADH_zinc_N PF00107.26 CRG89360.1 - 0.00061 19.8 0.1 0.0013 18.7 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF1776 PF08643.10 CRG89360.1 - 0.00077 18.9 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 CRG89360.1 - 0.0014 17.8 0.0 0.002 17.3 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 CRG89360.1 - 0.0053 17.0 0.0 0.012 15.9 0.0 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Thaumatin PF00314.17 CRG89361.1 - 3.2e-68 229.6 1.0 1.2e-67 227.7 1.0 1.8 1 1 0 1 1 1 1 Thaumatin family DUF3445 PF11927.8 CRG89361.1 - 2.4e-66 223.6 0.0 3.2e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3445) Glyco_hydro_64 PF16483.5 CRG89361.1 - 0.0065 15.8 0.1 0.77 9.0 0.0 2.2 2 0 0 2 2 2 2 Beta-1,3-glucanase Tryp_inh PF17983.1 CRG89361.1 - 0.14 12.3 4.6 0.51 10.5 4.6 2.0 1 0 0 1 1 1 0 Trypsin inhibitors 1,2 and 3 F-box-like PF12937.7 CRG89362.1 - 0.00012 21.9 3.3 0.033 14.1 0.3 2.6 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 CRG89362.1 - 0.0011 18.8 2.3 0.1 12.5 0.2 2.7 2 0 0 2 2 2 2 F-box domain 4HBT_3 PF13622.6 CRG89363.1 - 4.7e-81 272.7 0.2 6e-81 272.3 0.2 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CRG89363.1 - 2.5e-24 85.6 0.0 7.4e-12 45.3 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase MFS_1 PF07690.16 CRG89364.1 - 4e-38 131.2 46.3 1.6e-36 125.9 32.2 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89364.1 - 1.9e-16 60.0 4.7 1.9e-16 60.0 4.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CRG89364.1 - 2.6e-06 27.0 6.1 2.8e-06 26.9 0.6 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 CRG89364.1 - 0.00036 19.1 0.6 0.00036 19.1 0.6 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Ndc1_Nup PF09531.10 CRG89364.1 - 0.37 9.4 0.6 0.97 8.0 0.6 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAD_binding_3 PF01494.19 CRG89365.1 - 6.6e-19 68.3 0.3 5.1e-12 45.7 0.1 2.9 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG89365.1 - 0.00018 21.6 0.2 0.00048 20.3 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG89365.1 - 0.0013 19.3 0.1 0.032 14.8 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG89365.1 - 0.0019 17.0 0.3 0.004 15.9 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CRG89365.1 - 0.0034 17.0 0.7 0.0092 15.6 0.2 1.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG89365.1 - 0.031 13.3 0.0 0.29 10.2 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG89365.1 - 0.034 13.4 0.1 0.17 11.1 0.1 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG89365.1 - 0.038 13.3 0.1 0.07 12.4 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CRG89365.1 - 0.073 12.7 0.1 0.16 11.6 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA DUF1962 PF09227.10 CRG89366.1 - 0.0055 17.0 7.6 0.058 13.8 5.7 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1962) Alpha-amylase PF00128.24 CRG89367.1 - 6.9e-24 85.0 0.0 1.1e-23 84.4 0.0 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Glyco_hydro_70 PF02324.16 CRG89367.1 - 5e-08 31.6 0.2 0.12 10.5 0.0 3.1 3 0 0 3 3 3 3 Glycosyl hydrolase family 70 Acetyltransf_10 PF13673.7 CRG89369.1 - 1.2e-12 47.8 0.0 1.6e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG89369.1 - 1.4e-09 38.2 0.0 1.9e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_6 PF13480.7 CRG89369.1 - 1.1e-05 25.7 0.0 5.2e-05 23.4 0.0 1.8 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG89369.1 - 1.7e-05 25.2 0.0 2.4e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG89369.1 - 0.00062 19.9 0.0 0.0072 16.4 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 CRG89369.1 - 0.016 15.3 0.0 0.021 14.9 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Egh16-like PF11327.8 CRG89370.1 - 2.6e-48 164.9 2.9 3.2e-48 164.6 2.9 1.1 1 0 0 1 1 1 1 Egh16-like virulence factor RVT_1 PF00078.27 CRG89371.1 - 0.00048 19.7 0.0 0.00099 18.7 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) ERAP1_C PF11838.8 CRG89371.1 - 0.0082 15.7 3.2 1.6 8.2 0.1 2.7 2 1 0 2 2 2 2 ERAP1-like C-terminal domain Glyco_H_20C_C PF18088.1 CRG89371.1 - 0.05 13.4 0.2 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Glycoside Hydrolase 20C C-terminal domain Mito_carr PF00153.27 CRG89373.1 - 8.8e-43 144.2 7.3 6.5e-15 54.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Amidase PF01425.21 CRG89374.1 - 1.1e-73 248.7 0.0 1.1e-56 192.7 0.0 2.3 1 1 1 2 2 2 2 Amidase DUF3638 PF12340.8 CRG89375.1 - 4.8e-89 297.6 0.0 1.5e-88 295.9 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 CRG89375.1 - 1.1e-15 56.7 0.0 2.4e-15 55.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) adh_short_C2 PF13561.6 CRG89376.1 - 1.1e-44 152.8 0.6 1.4e-44 152.4 0.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89376.1 - 2.2e-39 135.0 0.8 3.5e-39 134.3 0.8 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89376.1 - 9.4e-10 38.7 0.3 1.5e-09 38.0 0.3 1.3 1 0 0 1 1 1 1 KR domain Amidase PF01425.21 CRG89377.1 - 2e-69 234.7 0.0 1.6e-68 231.8 0.0 2.2 1 1 0 1 1 1 1 Amidase Aldolase_II PF00596.21 CRG89378.1 - 9.4e-48 162.6 0.4 1.2e-47 162.3 0.4 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Acetyltransf_1 PF00583.25 CRG89379.1 - 1.5e-11 44.5 0.0 5.8e-11 42.7 0.0 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG89379.1 - 3.4e-11 43.4 0.0 7e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG89379.1 - 9.7e-11 41.7 0.0 2.1e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain AstA PF04958.12 CRG89379.1 - 0.0024 16.5 0.0 0.0046 15.6 0.0 1.4 1 0 0 1 1 1 1 Arginine N-succinyltransferase beta subunit Acetyltransf_CG PF14542.6 CRG89379.1 - 0.005 17.0 0.0 0.0095 16.0 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 CRG89379.1 - 0.014 15.4 0.0 0.04 14.0 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Abhydrolase_1 PF00561.20 CRG89380.1 - 3.5e-13 49.8 0.0 1.1e-10 41.6 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG89380.1 - 0.00056 19.2 0.0 0.0034 16.7 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG89380.1 - 0.0086 16.7 0.0 0.01 16.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CRG89380.1 - 0.095 12.2 0.0 0.79 9.2 0.0 2.1 2 0 0 2 2 2 0 Prolyl oligopeptidase family PAP_central PF04928.17 CRG89381.1 - 6e-108 359.5 0.0 8.2e-108 359.1 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 CRG89381.1 - 5.9e-59 198.5 0.0 1.1e-58 197.7 0.0 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain Sod_Fe_C PF02777.18 CRG89381.1 - 1.3e-34 118.5 0.1 3.7e-34 117.0 0.1 1.9 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 CRG89381.1 - 4.9e-26 91.0 1.6 1.3e-25 89.7 1.6 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain NTP_transf_2 PF01909.23 CRG89381.1 - 2.9e-11 43.5 0.0 6e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Glyco_hydro_31 PF01055.26 CRG89382.1 - 2.5e-143 478.5 7.9 3.3e-143 478.0 7.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG89382.1 - 1.8e-38 131.3 0.2 3.8e-38 130.2 0.2 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG89382.1 - 5.2e-09 36.3 0.5 2e-08 34.4 0.5 2.1 1 0 0 1 1 1 1 Galactose mutarotase-like Sugar_tr PF00083.24 CRG89383.1 - 2.3e-105 353.1 19.3 2.7e-105 352.8 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89383.1 - 1.5e-23 83.4 51.5 1.1e-21 77.2 25.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG89383.1 - 0.00062 18.2 1.1 0.00062 18.2 1.1 2.4 3 1 1 4 4 4 1 Organic Anion Transporter Polypeptide (OATP) family DUF962 PF06127.11 CRG89383.1 - 0.24 11.5 2.9 16 5.6 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Fungal_trans PF04082.18 CRG89384.1 - 1.1e-23 83.6 0.1 1.9e-21 76.3 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89384.1 - 9e-08 32.1 8.7 1.4e-07 31.5 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2318 PF10080.9 CRG89384.1 - 0.16 12.1 0.5 0.31 11.2 0.5 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Flavin_Reduct PF01613.18 CRG89385.1 - 1.2e-20 74.1 0.0 1.8e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain ORC4_C PF14629.6 CRG89385.1 - 0.058 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus DUF447 PF04289.12 CRG89385.1 - 0.14 12.0 0.1 0.25 11.1 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF447) Mucin PF01456.17 CRG89387.1 - 0.0099 15.9 5.3 0.013 15.5 5.3 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Pyr_redox_2 PF07992.14 CRG89388.1 - 1.1e-36 126.7 0.0 1.7e-34 119.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG89388.1 - 1e-09 38.8 0.0 4.1e-08 33.7 0.0 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG89388.1 - 0.0033 17.6 0.0 2.8 8.2 0.0 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain MFS_1 PF07690.16 CRG89389.1 - 9.1e-17 61.0 19.7 9.1e-17 61.0 19.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89389.1 - 0.69 8.7 14.3 0.026 13.4 5.7 2.4 2 1 0 2 2 2 0 Sugar (and other) transporter DUF5423 PF17461.2 CRG89389.1 - 1.7 7.4 3.6 4.6 6.0 3.6 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5423) HSP20 PF00011.21 CRG89390.1 - 1.6e-09 37.8 1.5 5.4e-08 32.9 0.1 2.3 1 1 1 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 CRG89390.1 - 8e-05 22.1 0.0 0.00065 19.2 0.0 2.2 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Polyketide_cyc2 PF10604.9 CRG89391.1 - 5.2e-09 36.5 0.0 6.2e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 CRG89391.1 - 4.1e-06 27.0 0.3 7.6e-06 26.2 0.3 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 CRG89391.1 - 0.1 12.9 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein DeoC PF01791.9 CRG89392.1 - 2e-11 44.0 0.8 2.7e-11 43.6 0.8 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase DUF1805 PF08827.11 CRG89392.1 - 0.0096 16.2 0.7 4.1 7.8 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF1805) 3HCDH PF00725.22 CRG89393.1 - 1.7e-22 79.8 0.0 5.2e-22 78.3 0.0 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 CRG89393.1 - 2.1e-21 76.6 0.0 2.3e-19 70.0 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 CRG89393.1 - 0.0024 17.5 0.0 0.015 14.9 0.0 2.1 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 CRG89393.1 - 0.016 15.7 0.0 0.039 14.5 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG89393.1 - 0.044 13.0 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 CRG89393.1 - 0.065 13.7 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 CRG89393.1 - 0.076 13.0 0.0 0.15 12.0 0.0 1.6 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 CRG89393.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 CRG89393.1 - 0.17 12.2 0.0 0.33 11.2 0.0 1.6 1 1 0 1 1 1 0 TrkA-N domain AlaDh_PNT_C PF01262.21 CRG89393.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Ank_2 PF12796.7 CRG89394.1 - 5.1e-48 161.6 0.0 6.5e-15 55.5 0.1 4.6 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 CRG89394.1 - 4.7e-39 131.2 1.8 3.3e-06 27.3 0.0 9.0 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.6 CRG89394.1 - 1.2e-37 127.8 3.1 5.1e-12 46.1 0.0 7.1 4 2 3 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG89394.1 - 2.4e-34 113.5 1.3 0.00085 19.6 0.0 10.1 10 0 0 10 10 10 5 Ankyrin repeat Ank_5 PF13857.6 CRG89394.1 - 9.8e-29 99.1 4.4 1.7e-06 28.2 0.0 6.3 3 1 1 5 5 5 4 Ankyrin repeats (many copies) CorA PF01544.18 CRG89394.1 - 8.8e-14 51.5 0.1 2.2e-13 50.2 0.1 1.7 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein UPF0182 PF03699.13 CRG89394.1 - 0.044 11.9 0.0 0.064 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) FAD_binding_3 PF01494.19 CRG89395.1 - 1.1e-22 80.8 0.0 8.1e-16 58.2 0.0 2.7 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG89395.1 - 0.001 19.3 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CRG89395.1 - 0.014 14.6 0.1 1.4 8.1 0.0 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG89395.1 - 0.036 13.2 0.0 0.075 12.1 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain SE PF08491.10 CRG89395.1 - 0.055 12.5 0.0 0.69 8.9 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase DAO PF01266.24 CRG89395.1 - 0.056 13.0 0.0 0.17 11.4 0.0 1.7 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG89395.1 - 0.064 12.5 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MORN PF02493.20 CRG89396.1 - 1.2e-21 75.2 77.4 0.0011 18.7 0.3 14.3 14 1 0 14 14 14 11 MORN repeat NACHT PF05729.12 CRG89396.1 - 3.4e-06 27.1 0.0 7.6e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CRG89396.1 - 0.00062 20.0 0.0 0.0016 18.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG89396.1 - 0.0024 18.3 0.0 0.01 16.3 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 CRG89396.1 - 0.08 12.2 0.4 7.9 5.6 0.0 2.2 2 0 0 2 2 2 0 KAP family P-loop domain A_deaminase PF00962.22 CRG89397.1 - 4.9e-36 124.7 0.0 5.9e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 CRG89397.1 - 0.00028 20.3 0.0 0.00041 19.8 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase family MFS_1 PF07690.16 CRG89398.1 - 6.1e-30 104.3 32.5 6.1e-30 104.3 32.5 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG89398.1 - 1.5e-06 27.7 4.4 1.5e-06 27.7 4.4 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB MerE PF05052.12 CRG89398.1 - 0.0094 15.9 4.4 0.71 9.8 0.7 2.8 2 0 0 2 2 2 2 MerE protein Aminotran_1_2 PF00155.21 CRG89400.1 - 8.1e-17 61.4 0.0 1.1e-16 61.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Pectate_lyase_3 PF12708.7 CRG89401.1 - 2.6e-97 324.8 19.7 1.7e-82 276.4 10.2 3.3 2 1 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CRG89401.1 - 1.9e-07 30.7 3.7 0.0012 18.5 0.1 3.2 3 0 0 3 3 3 2 N terminal extension of bacteriophage endosialidase Hamartin PF04388.12 CRG89401.1 - 9.4 4.8 5.5 13 4.3 5.5 1.1 1 0 0 1 1 1 0 Hamartin protein Flavin_Reduct PF01613.18 CRG89402.1 - 4.2e-19 69.1 0.1 6e-19 68.6 0.1 1.1 1 0 0 1 1 1 1 Flavin reductase like domain DUF3025 PF11227.8 CRG89402.1 - 0.094 12.5 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3025) UbiD PF01977.16 CRG89402.1 - 0.12 11.2 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Glyco_hydro_3_C PF01915.22 CRG89403.1 - 6.3e-44 150.4 0.0 1.1e-43 149.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG89403.1 - 8e-35 120.7 0.0 1.6e-34 119.7 0.0 1.4 2 0 0 2 2 2 1 Glycosyl hydrolase family 3 N terminal domain DDR PF08841.10 CRG89403.1 - 0.25 10.3 0.1 0.41 9.6 0.1 1.3 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain Lipase_GDSL PF00657.22 CRG89404.1 - 0.00037 20.5 0.0 0.00048 20.2 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 CRG89404.1 - 0.039 14.4 0.4 0.35 11.2 0.4 2.1 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Cation_efflux PF01545.21 CRG89405.1 - 1.8e-17 63.7 7.6 2.2e-17 63.4 7.6 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 CRG89405.1 - 1.3e-09 38.1 0.1 3.3e-09 36.7 0.1 1.7 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter GAT PF03127.14 CRG89406.1 - 3.7e-15 56.0 0.0 8.9e-15 54.8 0.0 1.7 1 0 0 1 1 1 1 GAT domain VHS PF00790.19 CRG89406.1 - 0.00062 19.6 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 VHS domain Corazonin PF17308.2 CRG89406.1 - 0.015 15.7 5.5 0.015 15.7 5.5 2.4 2 0 0 2 2 2 0 Pro-corazonin 2-Hacid_dh_C PF02826.19 CRG89407.1 - 5.3e-54 182.3 0.1 8.7e-54 181.6 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ribosomal_L22 PF00237.19 CRG89407.1 - 7.9e-41 138.5 0.3 5.4e-40 135.8 0.0 2.4 2 1 1 3 3 3 1 Ribosomal protein L22p/L17e 2-Hacid_dh PF00389.30 CRG89407.1 - 4e-15 55.7 0.0 6.5e-15 55.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG89407.1 - 7.2e-05 23.0 0.3 0.00017 21.8 0.3 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ADH_N PF08240.12 CRG89408.1 - 1.4e-29 102.1 0.1 2.6e-29 101.3 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89408.1 - 4.8e-13 49.2 0.5 4.8e-13 49.2 0.5 1.9 2 1 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG89408.1 - 2.7e-12 46.6 0.8 8e-06 25.5 0.1 2.2 1 1 1 2 2 2 2 Glucose dehydrogenase C-terminus Sacchrp_dh_NADP PF03435.18 CRG89408.1 - 0.0093 16.2 0.6 0.024 14.9 0.1 1.9 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ApbA PF02558.16 CRG89408.1 - 0.022 14.4 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 CRG89408.1 - 0.054 12.8 0.0 0.093 12.1 0.0 1.3 1 0 0 1 1 1 0 ThiF family UDPG_MGDP_dh_N PF03721.14 CRG89408.1 - 0.078 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 CRG89408.1 - 0.096 12.9 0.1 0.26 11.6 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain adh_short_C2 PF13561.6 CRG89409.1 - 8.2e-44 149.9 0.3 1.3e-43 149.3 0.3 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89409.1 - 5.6e-43 146.7 0.2 1.2e-42 145.6 0.2 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89409.1 - 3.6e-12 46.6 0.2 7.5e-12 45.5 0.2 1.5 1 0 0 1 1 1 1 KR domain Fungal_trans PF04082.18 CRG89409.1 - 1.4e-07 30.8 0.0 1e-06 28.0 0.0 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89409.1 - 5.4e-07 29.6 6.4 1e-06 28.8 6.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GDP_Man_Dehyd PF16363.5 CRG89409.1 - 6.4e-06 25.8 0.0 1.7e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CRG89409.1 - 2.1e-05 24.1 0.1 4.6e-05 23.0 0.1 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG89409.1 - 0.0012 18.8 0.3 0.0029 17.5 0.1 1.8 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CRG89409.1 - 0.002 17.3 0.0 0.003 16.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 CRG89409.1 - 0.19 10.8 0.0 0.35 9.9 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short_C2 PF13561.6 CRG89410.1 - 3.3e-55 187.2 0.1 4.3e-55 186.8 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89410.1 - 2.2e-50 170.8 0.2 4e-50 170.0 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG89410.1 - 2.4e-09 37.3 0.3 5.8e-09 36.1 0.0 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CRG89410.1 - 2.2e-07 30.6 0.0 3.5e-07 29.9 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CRG89410.1 - 0.00061 19.0 0.2 0.0069 15.5 0.1 2.3 2 1 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CRG89410.1 - 0.00065 19.2 0.0 0.001 18.5 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CRG89410.1 - 0.024 13.8 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein ADH_zinc_N PF00107.26 CRG89410.1 - 0.042 13.8 0.1 0.088 12.8 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ApbA PF02558.16 CRG89410.1 - 0.083 12.5 0.0 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF2103 PF09876.9 CRG89410.1 - 0.13 12.2 0.1 0.72 9.9 0.0 2.0 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2103) THF_DHG_CYH_C PF02882.19 CRG89410.1 - 0.14 11.5 0.5 0.73 9.1 0.1 2.1 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Mur_ligase PF01225.25 CRG89410.1 - 0.17 12.3 0.4 0.85 10.0 0.1 2.1 2 0 0 2 2 2 0 Mur ligase family, catalytic domain Glyco_transf_5 PF08323.11 CRG89410.1 - 0.17 11.5 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Starch synthase catalytic domain Ferric_reduct PF01794.19 CRG89411.1 - 1.3e-22 80.3 12.0 2.7e-22 79.2 12.0 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG89411.1 - 6.4e-14 52.4 0.0 1.4e-11 44.8 0.0 2.7 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG89411.1 - 1.8e-09 37.7 0.1 2e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 CRG89411.1 - 0.016 15.8 0.0 0.041 14.5 0.0 1.7 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain UBA_4 PF14555.6 CRG89412.1 - 1.8e-12 46.9 0.0 3.7e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 CRG89412.1 - 2e-09 37.5 0.0 4.3e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 UBX domain DUF1682 PF07946.14 CRG89412.1 - 0.05 12.8 3.5 0.08 12.1 3.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pan3_PK PF18101.1 CRG89413.1 - 3.2e-63 211.8 0.2 5.4e-63 211.1 0.2 1.4 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 CRG89413.1 - 8.6e-06 25.3 0.0 1.4e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89413.1 - 0.041 13.2 0.1 0.067 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase LSM PF01423.22 CRG89414.1 - 5.4e-21 74.0 0.5 6.9e-21 73.7 0.5 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 CRG89414.1 - 0.018 15.1 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 RimP C-terminal SH3 domain SM-ATX PF14438.6 CRG89414.1 - 0.026 14.7 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain baeRF_family7 PF18849.1 CRG89414.1 - 0.026 14.7 0.1 0.036 14.3 0.1 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 7 baeRF_family6 PF18848.1 CRG89414.1 - 0.11 12.9 0.2 0.14 12.5 0.2 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 FoP_duplication PF13865.6 CRG89414.1 - 4.4 7.9 19.7 12 6.5 19.4 1.9 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Zn_clus PF00172.18 CRG89415.1 - 0.033 14.3 9.8 0.075 13.2 9.8 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Dioxygenase_C PF00775.21 CRG89416.1 - 6.1e-41 139.9 0.0 8.1e-41 139.4 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 CRG89416.1 - 9e-33 112.0 0.0 1.5e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 CRG89416.1 - 0.028 14.7 0.0 0.097 13.0 0.0 1.9 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Vps39_2 PF10367.9 CRG89417.1 - 7e-07 29.7 0.0 3.9e-06 27.3 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 CRG89417.1 - 5.2e-05 23.5 0.0 0.0022 18.3 0.0 2.9 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 CASP_C PF08172.12 CRG89418.1 - 8.4e-88 294.0 2.8 8.4e-88 294.0 2.8 3.4 3 1 0 3 3 3 1 CASP C terminal Flagellin_IN PF07196.13 CRG89418.1 - 0.001 19.2 0.2 0.0037 17.4 0.2 1.9 1 0 0 1 1 1 1 Flagellin hook IN motif SAT PF16073.5 CRG89418.1 - 0.014 15.2 0.2 0.048 13.4 0.2 1.9 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Fib_alpha PF08702.10 CRG89418.1 - 0.016 15.4 6.5 0.016 15.4 6.5 4.3 4 1 0 4 4 4 0 Fibrinogen alpha/beta chain family betaPIX_CC PF16523.5 CRG89418.1 - 0.13 12.1 17.9 0.023 14.5 2.6 4.4 3 2 0 3 3 3 0 betaPIX coiled coil K_channel_TID PF07941.11 CRG89418.1 - 0.24 11.9 15.3 0.96 10.0 10.7 2.8 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain COX16 PF14138.6 CRG89418.1 - 0.33 11.5 0.1 0.33 11.5 0.1 5.0 4 1 0 4 4 4 0 Cytochrome c oxidase assembly protein COX16 DUF1664 PF07889.12 CRG89418.1 - 2 8.5 28.7 7.5 6.6 3.7 5.7 3 2 3 6 6 6 0 Protein of unknown function (DUF1664) GFO_IDH_MocA PF01408.22 CRG89419.1 - 1.1e-17 65.0 0.0 1.6e-17 64.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG89419.1 - 0.0041 17.8 0.0 0.0061 17.2 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Peptidase_M16 PF00675.20 CRG89420.1 - 6.3e-57 191.7 1.1 1.2e-56 190.8 0.5 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 CRG89420.1 - 2.3e-33 115.8 0.0 1.1e-31 110.3 0.0 2.3 2 0 0 2 2 2 2 Peptidase M16 inactive domain Epimerase PF01370.21 CRG89421.1 - 1.4e-20 73.8 0.0 1.8e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG89421.1 - 1.3e-13 50.6 0.0 1.7e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG89421.1 - 1.9e-09 37.4 0.0 3.2e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG89421.1 - 1.1e-06 28.0 0.0 1.7e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG89421.1 - 0.00048 19.4 0.0 0.079 12.1 0.0 2.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CRG89421.1 - 0.00051 20.0 0.0 0.00078 19.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 CRG89421.1 - 0.00084 18.8 0.0 0.026 14.0 0.0 2.3 2 1 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG89421.1 - 0.004 17.4 0.0 0.0092 16.2 0.0 1.6 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 CRG89421.1 - 0.022 14.7 0.0 0.044 13.7 0.0 1.4 1 1 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 CRG89421.1 - 0.1 11.7 0.0 0.52 9.4 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Ldh_1_N PF00056.23 CRG89421.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CRG89422.1 - 6.5e-20 71.7 0.0 1.8e-11 43.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CRG89422.1 - 4e-07 29.6 0.1 0.0032 16.8 0.2 2.7 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG89422.1 - 5.3e-07 29.6 1.0 0.0031 17.1 0.9 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG89422.1 - 3.5e-06 27.1 0.5 8e-06 26.0 0.5 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG89422.1 - 0.00013 21.2 1.1 0.0075 15.4 2.5 2.2 1 1 1 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 CRG89422.1 - 0.0044 15.9 0.1 0.0067 15.3 0.1 1.3 1 0 0 1 1 1 1 Tryptophan halogenase Pyr_redox PF00070.27 CRG89422.1 - 0.011 16.3 0.1 2.4 8.8 0.2 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 CRG89422.1 - 0.019 14.3 0.2 0.031 13.6 0.2 1.3 1 0 0 1 1 1 0 ThiF family FAD_oxidored PF12831.7 CRG89422.1 - 0.033 13.5 0.4 0.08 12.3 0.4 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG89422.1 - 0.054 12.7 0.4 0.38 10.0 0.3 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG89422.1 - 0.059 12.6 0.4 0.13 11.5 0.4 1.5 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 CRG89422.1 - 0.14 11.2 0.5 0.25 10.4 0.5 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Fibrillarin PF01269.17 CRG89423.1 - 2.9e-103 343.8 0.0 3.6e-103 343.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 CRG89423.1 - 2.5e-05 24.1 0.0 5.3e-05 23.0 0.0 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 CRG89423.1 - 0.0095 15.6 0.0 0.021 14.4 0.0 1.6 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 CRG89423.1 - 0.039 13.7 0.0 0.055 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CRG89423.1 - 0.14 12.2 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF3455 PF11937.8 CRG89424.1 - 1.3e-46 158.9 0.5 1.7e-46 158.5 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) DUF2990 PF11693.8 CRG89424.1 - 9.2e-21 73.8 0.4 9.2e-21 73.8 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2990) Pkinase PF00069.25 CRG89425.1 - 8.8e-25 87.6 0.0 9.2e-24 84.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89425.1 - 1e-08 34.8 0.0 1.8e-06 27.4 0.0 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase CHASE8 PF17152.4 CRG89426.1 - 0.02 15.1 0.0 0.03 14.6 0.0 1.3 1 0 0 1 1 1 0 Periplasmic sensor domain Orthopox_F8 PF05886.11 CRG89426.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Orthopoxvirus F8 protein ADH_zinc_N PF00107.26 CRG89427.1 - 5.1e-23 81.5 0.0 7.6e-23 80.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CRG89427.1 - 3.8e-21 75.0 0.0 8.3e-21 73.9 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Glyco_transf_34 PF05637.12 CRG89427.1 - 6.3e-18 65.4 0.0 1.6e-10 41.1 0.0 2.2 1 1 1 2 2 2 2 galactosyl transferase GMA12/MNN10 family ADH_zinc_N_2 PF13602.6 CRG89427.1 - 4.6e-05 24.5 0.0 9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase CybS PF05328.12 CRG89428.1 - 2.2e-50 169.8 0.1 2.7e-50 169.5 0.1 1.2 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Maf PF02545.14 CRG89429.1 - 5.1e-48 163.1 0.1 6e-48 162.8 0.1 1.0 1 0 0 1 1 1 1 Maf-like protein GFA PF04828.14 CRG89431.1 - 0.014 15.7 0.1 0.081 13.3 0.0 2.3 2 1 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme HLH PF00010.26 CRG89432.1 - 3.9e-08 33.1 0.0 6.2e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF1387 PF07139.11 CRG89433.1 - 0.2 11.4 6.3 0.26 11.0 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) adh_short PF00106.25 CRG89434.1 - 3.8e-45 153.8 0.1 6.1e-45 153.1 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89434.1 - 3.6e-28 98.7 0.0 5.5e-28 98.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89434.1 - 8.6e-09 35.6 0.1 1.4e-08 34.9 0.1 1.2 1 0 0 1 1 1 1 KR domain F-box-like PF12937.7 CRG89434.1 - 4.2e-07 29.7 0.1 1.4e-06 28.1 0.0 2.0 2 0 0 2 2 2 1 F-box-like DUF1776 PF08643.10 CRG89434.1 - 2.6e-05 23.8 0.0 5.9e-05 22.6 0.0 1.7 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CRG89434.1 - 0.0019 17.7 0.1 0.0035 16.8 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F-box PF00646.33 CRG89434.1 - 0.007 16.2 1.4 0.27 11.1 0.3 3.2 2 1 0 2 2 2 1 F-box domain PAXIP1_C PF15364.6 CRG89434.1 - 0.094 13.0 0.4 0.23 11.7 0.4 1.6 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein RmlD_sub_bind PF04321.17 CRG89434.1 - 0.16 11.0 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 CRG89434.1 - 0.17 11.2 0.0 0.3 10.4 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 CRG89434.1 - 0.17 11.2 0.1 0.32 10.3 0.1 1.5 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase DUF5389 PF17364.2 CRG89435.1 - 0.0028 17.6 0.8 0.077 13.1 0.0 2.5 2 0 0 2 2 2 1 Family of unknown function (DUF5389) DUF3742 PF12553.8 CRG89435.1 - 0.23 11.6 2.2 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) NrsF PF06532.11 CRG89435.1 - 0.56 9.9 13.9 0.12 12.1 5.3 2.4 2 1 1 3 3 3 0 Negative regulator of sigma F TraS PF10624.9 CRG89435.1 - 0.7 9.8 5.9 1.6 8.6 5.9 1.7 1 1 0 1 1 1 0 Plasmid conjugative transfer entry exclusion protein TraS MTABC_N PF16185.5 CRG89435.1 - 7.6 6.0 12.7 3 7.3 0.5 2.1 1 1 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region Fungal_trans_2 PF11951.8 CRG89436.1 - 4.9e-06 25.6 0.2 8.1e-06 24.9 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89436.1 - 0.021 14.9 2.5 0.021 14.9 2.5 2.5 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 CRG89437.1 - 6.1e-22 78.0 0.0 1.6e-17 63.6 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89437.1 - 5.4e-12 45.8 0.3 8.8e-11 41.8 0.3 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89437.1 - 0.0012 18.8 0.2 0.0029 17.5 0.1 1.7 2 0 0 2 2 2 1 KR domain DUF3060 PF11259.8 CRG89437.1 - 0.093 12.4 0.9 0.21 11.3 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3060) VWA PF00092.28 CRG89440.1 - 0.00031 21.1 0.0 0.00078 19.7 0.0 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 CRG89440.1 - 0.0043 17.7 0.0 0.013 16.1 0.0 1.8 2 0 0 2 2 2 1 von Willebrand factor type A domain ANAPC4 PF12896.7 CRG89441.1 - 1.2e-68 230.7 1.7 2.1e-68 229.9 1.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 CRG89441.1 - 1.2e-27 96.0 0.0 8.7e-27 93.3 0.0 2.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain CorA PF01544.18 CRG89442.1 - 2.8e-09 36.7 0.1 5.5e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF373 PF04123.13 CRG89442.1 - 0.079 12.4 0.6 0.13 11.7 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) HEAT PF02985.22 CRG89443.1 - 3.3e-17 61.1 8.7 0.00015 21.7 0.1 9.2 9 1 0 9 9 9 3 HEAT repeat HEAT_EZ PF13513.6 CRG89443.1 - 3.6e-13 49.7 7.4 1.6e-06 28.5 0.0 7.1 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 CRG89443.1 - 1.5e-09 38.1 9.3 0.0013 19.1 0.1 6.7 5 2 2 7 7 7 3 HEAT repeats IBN_N PF03810.19 CRG89443.1 - 7.5e-08 32.2 2.7 5.6e-07 29.4 0.1 3.8 5 0 0 5 5 5 1 Importin-beta N-terminal domain Ecm29 PF13001.7 CRG89443.1 - 5.2e-05 22.1 0.0 0.34 9.5 0.0 3.1 2 1 0 2 2 2 2 Proteasome stabiliser CLASP_N PF12348.8 CRG89443.1 - 0.00022 20.9 0.1 0.1 12.2 0.0 3.9 2 1 0 3 3 3 1 CLASP N terminal Dopey_N PF04118.14 CRG89443.1 - 0.04 13.0 0.2 0.086 11.9 0.2 1.5 1 0 0 1 1 1 0 Dopey, N-terminal Arm PF00514.23 CRG89443.1 - 1.2 9.3 5.9 21 5.4 0.0 5.3 7 0 0 7 7 7 0 Armadillo/beta-catenin-like repeat Ribosomal_S8 PF00410.19 CRG89444.1 - 3.2e-21 75.6 0.1 4.8e-21 75.0 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 His_Phos_1 PF00300.22 CRG89445.1 - 2.5e-12 46.9 0.0 1.5e-11 44.4 0.0 2.0 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Archease PF01951.16 CRG89445.1 - 0.11 12.7 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) ubiquitin PF00240.23 CRG89446.1 - 1.2e-05 25.0 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 CRG89446.1 - 0.16 12.6 0.4 0.5 10.9 0.0 2.1 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain PS_Dcarbxylase PF02666.15 CRG89447.1 - 2.7e-79 265.4 0.0 9.3e-79 263.6 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase ANAPC10 PF03256.16 CRG89448.1 - 9.7e-43 146.0 0.0 1.4e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) RNA_pol_3_Rpc31 PF11705.8 CRG89448.1 - 0.0072 16.6 4.9 0.0072 16.6 4.9 2.3 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 SWIRM-assoc_2 PF16496.5 CRG89448.1 - 0.74 8.6 8.7 0.55 9.0 1.7 2.3 2 0 0 2 2 2 0 SWIRM-associated domain at the N-terminal PI3K_1B_p101 PF10486.9 CRG89448.1 - 3.8 5.2 3.6 5.3 4.7 3.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RXT2_N PF08595.11 CRG89448.1 - 4.4 7.3 14.8 2.2 8.3 0.7 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal TRAP_alpha PF03896.16 CRG89448.1 - 7.6 5.7 10.5 16 4.6 10.5 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 CRG89448.1 - 9.8 5.8 12.2 12 5.6 6.0 2.5 2 0 0 2 2 2 0 FAM176 family Iso_dh PF00180.20 CRG89449.1 - 6.6e-123 410.3 0.0 7.5e-123 410.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase CDP-OH_P_transf PF01066.21 CRG89450.1 - 8.9e-13 48.8 2.2 9.2e-13 48.8 0.5 2.0 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PP2C PF00481.21 CRG89451.1 - 1.4e-33 116.6 0.0 2.1e-27 96.4 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 CRG89451.1 - 0.0034 17.1 0.0 0.0065 16.1 0.0 1.5 1 0 0 1 1 1 1 Protein phosphatase 2C kleA_kleC PF17383.2 CRG89452.1 - 0.0024 18.2 1.1 0.0066 16.7 1.1 1.7 1 0 0 1 1 1 1 Uncharacterized KorC regulated protein A Spc7 PF08317.11 CRG89452.1 - 0.0027 16.7 3.9 0.0045 15.9 3.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein FmiP_Thoc5 PF09766.9 CRG89452.1 - 0.012 14.9 2.6 0.016 14.5 2.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 ADIP PF11559.8 CRG89452.1 - 0.013 15.6 5.4 0.021 14.9 5.4 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding CEP63 PF17045.5 CRG89452.1 - 0.018 14.9 3.1 0.029 14.3 3.1 1.2 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa NPV_P10 PF05531.12 CRG89452.1 - 0.028 14.9 1.4 0.069 13.6 1.4 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF16 PF01519.16 CRG89452.1 - 0.029 14.8 3.4 0.066 13.7 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 SlyX PF04102.12 CRG89452.1 - 0.03 14.9 10.5 0.14 12.8 10.5 2.2 1 1 0 1 1 1 0 SlyX DASH_Spc19 PF08287.11 CRG89452.1 - 0.031 14.2 1.0 0.065 13.1 0.5 1.7 2 0 0 2 2 2 0 Spc19 zf-C4H2 PF10146.9 CRG89452.1 - 0.058 13.7 3.0 0.11 12.8 3.0 1.4 1 0 0 1 1 1 0 Zinc finger-containing protein ATG16 PF08614.11 CRG89452.1 - 0.061 13.5 4.5 0.14 12.4 4.5 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 CRG89452.1 - 0.074 13.2 3.2 0.13 12.5 3.2 1.3 1 0 0 1 1 1 0 Tropomyosin like BST2 PF16716.5 CRG89452.1 - 0.075 13.6 1.8 0.18 12.4 1.8 1.6 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 HMMR_N PF15905.5 CRG89452.1 - 0.086 12.3 2.0 0.13 11.7 2.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal PKcGMP_CC PF16808.5 CRG89452.1 - 0.13 12.1 6.0 0.042 13.7 2.2 2.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Filament PF00038.21 CRG89452.1 - 0.15 11.6 5.2 0.24 10.9 5.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein HrpB7 PF09486.10 CRG89452.1 - 0.19 12.1 5.6 0.33 11.3 5.6 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DivIC PF04977.15 CRG89452.1 - 0.21 11.4 5.5 0.28 11.0 2.4 2.3 2 0 0 2 2 2 0 Septum formation initiator HAP1_N PF04849.13 CRG89452.1 - 0.22 10.7 4.3 0.34 10.1 4.3 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Spc24 PF08286.11 CRG89452.1 - 0.22 11.8 1.2 0.78 10.0 1.2 1.9 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.10 CRG89452.1 - 0.23 11.7 4.4 0.25 11.5 3.1 1.7 2 0 0 2 2 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 CRG89452.1 - 0.24 11.7 1.9 0.57 10.5 1.9 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 phiKZ_IP PF12699.7 CRG89452.1 - 0.27 10.3 1.3 0.34 10.0 0.6 1.5 2 0 0 2 2 2 0 phiKZ-like phage internal head proteins DUF4349 PF14257.6 CRG89452.1 - 0.46 9.9 2.8 0.81 9.1 2.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF1664 PF07889.12 CRG89452.1 - 0.52 10.4 2.7 1.2 9.2 2.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 CRG89452.1 - 0.63 10.1 5.1 1.2 9.2 5.1 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Atg14 PF10186.9 CRG89452.1 - 0.89 8.6 4.5 1.5 7.8 4.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RRM_1 PF00076.22 CRG89453.1 - 3.9e-42 141.9 0.6 8.7e-21 73.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 CRG89453.1 - 8.9e-24 84.4 0.2 3.8e-23 82.4 0.2 2.2 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 CRG89453.1 - 0.00013 21.7 0.0 0.28 11.1 0.0 2.8 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 CRG89453.1 - 0.021 14.9 0.0 0.084 12.9 0.0 2.0 1 0 0 1 1 1 0 RNA binding motif PHM7_cyt PF14703.6 CRG89453.1 - 0.029 14.6 0.0 4.7 7.4 0.0 2.8 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RRM_5 PF13893.6 CRG89453.1 - 0.052 13.2 0.0 0.66 9.6 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG89453.1 - 0.055 13.6 0.0 1.9 8.6 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif Cyt-b5 PF00173.28 CRG89454.1 - 1.3e-20 73.3 0.3 1.3e-20 73.3 0.3 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 CRG89454.1 - 1.2e-14 54.7 16.3 2.8e-14 53.6 15.6 1.8 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 CRG89454.1 - 0.15 12.3 0.2 0.15 12.3 0.2 2.0 2 0 0 2 2 2 0 Anthranilate synthase component I, N terminal region Glyco_hydro_18 PF00704.28 CRG89455.1 - 1.5e-25 90.6 1.6 2.9e-25 89.7 1.6 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 OMPdecase PF00215.24 CRG89456.1 - 1.8e-07 31.0 0.0 0.0072 15.9 0.0 2.7 2 1 0 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family TFB6 PF17110.5 CRG89457.1 - 0.018 14.8 0.4 0.033 13.9 0.4 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Sigma70_ner PF04546.13 CRG89457.1 - 0.022 14.7 3.3 0.057 13.3 3.3 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region CPSF100_C PF13299.6 CRG89457.1 - 0.21 11.8 1.2 0.45 10.7 1.2 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 CRG89457.1 - 0.91 9.2 5.5 1.9 8.1 5.5 1.4 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 CRG89457.1 - 0.96 9.9 8.7 2 8.9 8.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4746 PF15928.5 CRG89457.1 - 1.2 8.5 6.5 2 7.7 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DNA_pol_phi PF04931.13 CRG89457.1 - 1.3 7.0 8.1 2 6.4 8.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 CRG89457.1 - 1.5 7.1 5.3 2.2 6.5 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 CRG89457.1 - 2.2 6.3 5.0 3.5 5.6 5.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Paf1 PF03985.13 CRG89457.1 - 2.5 7.0 9.7 4 6.3 9.7 1.2 1 0 0 1 1 1 0 Paf1 DUF4637 PF15470.6 CRG89457.1 - 7.3 6.3 9.6 19 4.9 9.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pox_Ag35 PF03286.14 CRG89457.1 - 8.7 6.1 8.8 15 5.3 8.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Fungal_trans PF04082.18 CRG89458.1 - 3.4e-23 82.0 2.1 6.9e-23 81.0 2.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Sigma70_ner PF04546.13 CRG89458.1 - 0.029 14.3 6.8 0.091 12.6 6.8 1.9 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4589 PF15252.6 CRG89458.1 - 0.032 14.3 5.9 0.17 11.9 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4589) Peptidase_M13_N PF05649.13 CRG89458.1 - 0.033 13.9 0.1 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Peptidase family M13 CobT PF06213.12 CRG89458.1 - 0.052 12.9 8.1 0.11 11.9 8.1 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 CRG89458.1 - 0.16 11.6 6.2 0.54 9.9 6.2 1.9 1 0 0 1 1 1 0 FAM176 family DUF3391 PF11871.8 CRG89458.1 - 0.18 12.3 2.2 0.77 10.3 2.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF4637 PF15470.6 CRG89458.1 - 0.24 11.1 16.0 0.03 14.0 11.3 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4637) DNA_pol_phi PF04931.13 CRG89458.1 - 0.44 8.6 15.4 0.7 7.9 15.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 CRG89458.1 - 0.52 10.3 5.5 1.6 8.7 5.5 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal Nop14 PF04147.12 CRG89458.1 - 0.93 7.6 14.6 1.9 6.6 14.6 1.4 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 CRG89458.1 - 1.7 7.6 17.1 3.4 6.6 17.1 1.4 1 0 0 1 1 1 0 Paf1 RR_TM4-6 PF06459.12 CRG89458.1 - 1.8 8.3 9.2 4 7.2 9.2 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cytomega_UL84 PF06284.11 CRG89458.1 - 1.8 6.9 9.6 3.3 6.1 9.6 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RPN2_C PF18004.1 CRG89458.1 - 2.7 7.9 9.4 5.8 6.8 9.4 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain XAP5 PF04921.14 CRG89458.1 - 2.7 7.7 7.4 5 6.9 6.5 1.8 2 0 0 2 2 2 0 XAP5, circadian clock regulator CENP-B_dimeris PF09026.10 CRG89458.1 - 3.8 7.9 16.4 11 6.5 16.4 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 CRG89458.1 - 4.7 6.4 14.9 13 5.0 14.9 1.7 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 CRG89458.1 - 7.4 5.7 9.1 16 4.6 9.1 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop53 PF07767.11 CRG89458.1 - 7.6 5.8 16.4 16 4.8 16.4 1.4 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Adap_comp_sub PF00928.21 CRG89459.1 - 3.1e-19 69.4 0.0 4.8e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 CRG89459.1 - 3e-07 30.5 0.1 5e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RPM2 PF08579.11 CRG89459.1 - 0.0033 17.8 0.2 0.0078 16.6 0.2 1.6 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) DUF2420 PF10336.9 CRG89460.1 - 6.2e-18 64.8 0.1 1.1e-17 64.0 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Mg_trans_NIPA PF05653.14 CRG89461.1 - 2e-102 342.3 14.7 2.4e-102 342.1 14.7 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 CRG89461.1 - 6.6e-05 23.1 33.0 0.0002 21.5 4.3 3.2 3 0 0 3 3 3 3 EamA-like transporter family Syja_N PF02383.18 CRG89462.1 - 1.9e-92 310.0 0.0 3.2e-92 309.3 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 CRG89462.1 - 7.9e-39 131.9 0.0 1.5e-38 131.0 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase CCDC85 PF10226.9 CRG89462.1 - 0.0097 15.6 0.9 0.024 14.3 0.1 2.0 2 0 0 2 2 2 1 CCDC85 family HEAT_EZ PF13513.6 CRG89463.1 - 2.3e-36 123.8 12.9 1.1e-15 57.8 0.0 9.8 8 2 2 10 10 10 6 HEAT-like repeat HEAT PF02985.22 CRG89463.1 - 1.6e-25 86.9 12.7 7.8e-05 22.6 0.0 10.8 11 0 0 11 11 10 5 HEAT repeat HEAT_2 PF13646.6 CRG89463.1 - 9.7e-20 70.8 2.9 7.9e-06 26.2 0.0 8.0 6 3 5 11 11 11 6 HEAT repeats Cnd1 PF12717.7 CRG89463.1 - 5.1e-12 46.1 0.3 0.00012 22.2 0.0 5.5 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CRG89463.1 - 1.1e-09 38.7 0.1 0.065 13.8 0.0 5.7 4 2 2 6 6 5 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 CRG89463.1 - 1.5e-08 33.6 0.0 0.0032 16.1 0.0 3.4 2 1 1 3 3 3 3 Adaptin N terminal region CLASP_N PF12348.8 CRG89463.1 - 6e-08 32.5 2.0 1.3 8.6 0.0 6.2 4 3 2 6 6 6 3 CLASP N terminal Arm PF00514.23 CRG89463.1 - 8.3e-07 28.8 7.0 0.22 11.6 0.1 6.6 7 0 0 7 7 6 2 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 CRG89463.1 - 5.5e-06 25.7 14.6 0.045 12.9 0.0 6.0 4 2 0 5 5 5 2 RNAPII transcription regulator C-terminal DRIM PF07539.12 CRG89463.1 - 6.8e-05 21.4 0.0 0.0074 14.7 0.0 3.6 3 1 0 3 3 3 1 Down-regulated in metastasis RIX1 PF08167.12 CRG89463.1 - 0.00012 21.9 0.1 4.5 7.0 0.0 5.7 5 1 0 5 5 5 1 rRNA processing/ribosome biogenesis Tti2 PF10521.9 CRG89463.1 - 0.00035 20.2 0.2 2.5 7.5 0.1 4.4 2 2 2 4 4 4 1 Tti2 family Xpo1 PF08389.12 CRG89463.1 - 0.0036 17.4 2.1 0.65 10.0 0.0 4.6 4 2 0 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 CRG89463.1 - 0.0053 16.7 0.2 3.8 7.5 0.0 4.5 5 1 0 5 5 4 1 Importin-beta N-terminal domain TIP120 PF08623.10 CRG89463.1 - 0.014 15.2 0.0 2.4 7.9 0.0 3.9 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) DUF3437 PF11919.8 CRG89463.1 - 0.015 15.2 0.0 0.85 9.6 0.0 3.9 4 1 0 4 4 4 0 Domain of unknown function (DUF3437) RTP1_C1 PF10363.9 CRG89463.1 - 0.019 15.1 0.3 8.7 6.6 0.0 4.1 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 MOR2-PAG1_N PF14222.6 CRG89463.1 - 0.47 9.3 2.9 14 4.5 0.1 2.9 3 1 0 4 4 4 0 Cell morphogenesis N-terminal Beta-lactamase PF00144.24 CRG89464.1 - 4.2e-47 161.0 0.0 1.3e-46 159.4 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase Glutaminase PF04960.15 CRG89464.1 - 0.19 10.9 0.1 3.5 6.7 0.0 2.4 2 1 1 3 3 3 0 Glutaminase Fungal_trans_2 PF11951.8 CRG89465.1 - 0.0002 20.3 0.3 0.00036 19.5 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_C12 PF01088.21 CRG89466.1 - 5.2e-69 232.2 0.0 7.1e-69 231.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 CRG89466.1 - 3.4e-09 36.4 0.0 8.2e-09 35.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Choline_kinase PF01633.20 CRG89467.1 - 5.2e-59 199.4 0.0 1.2e-58 198.2 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 CRG89467.1 - 5.8e-15 54.7 0.0 3.2e-14 52.3 0.0 2.2 2 0 0 2 2 2 1 Choline kinase N terminus APH PF01636.23 CRG89467.1 - 6.3e-07 29.6 0.6 1.3e-06 28.5 0.6 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Imm1 PF14430.6 CRG89467.1 - 0.0038 17.9 0.0 0.045 14.4 0.0 2.5 2 0 0 2 2 2 1 Immunity protein Imm1 Phosphoesterase PF04185.14 CRG89468.1 - 1.2e-68 231.9 4.1 1.7e-68 231.5 4.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family Tim17 PF02466.19 CRG89469.1 - 1.5e-30 105.8 6.9 1.9e-30 105.5 6.9 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Cu-oxidase_3 PF07732.15 CRG89470.1 - 3e-40 136.9 0.0 2.4e-38 130.8 0.0 2.5 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG89470.1 - 1.8e-35 121.6 4.0 1.9e-33 115.1 0.5 3.2 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 CRG89470.1 - 2.6e-17 63.4 0.0 2.1e-14 54.0 0.0 2.8 3 0 0 3 3 3 2 Multicopper oxidase Mem_trans PF03547.18 CRG89471.1 - 5.3e-56 189.7 0.7 1.5e-55 188.2 0.7 1.6 1 1 0 1 1 1 1 Membrane transport protein Pkinase PF00069.25 CRG89472.1 - 3.3e-55 187.3 0.0 3.5e-52 177.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89472.1 - 9.9e-33 113.5 0.0 7.2e-32 110.7 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 CRG89472.1 - 0.0017 17.4 0.1 0.0028 16.8 0.1 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kinase-like PF14531.6 CRG89472.1 - 0.0027 17.1 0.0 0.0039 16.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 CRG89472.1 - 0.09 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Auxin_repressed PF05564.12 CRG89472.1 - 2.9 8.6 13.5 9.1 7.0 0.4 3.4 3 0 0 3 3 3 0 Dormancy/auxin associated protein Pyr_redox_2 PF07992.14 CRG89473.1 - 2.7e-56 191.0 2.1 4.3e-56 190.3 2.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MFS_1 PF07690.16 CRG89473.1 - 1.9e-34 119.1 21.8 2.6e-34 118.7 21.8 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Pyr_redox_dim PF02852.22 CRG89473.1 - 5.5e-31 107.1 0.0 1.4e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CRG89473.1 - 5.3e-14 52.5 0.1 5.3e-14 52.5 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG89473.1 - 2.7e-08 33.4 2.6 8e-08 31.9 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG89473.1 - 2.9e-05 23.4 0.0 5.7e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 CRG89473.1 - 0.015 14.4 0.8 0.063 12.3 0.1 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 CRG89473.1 - 0.062 12.6 0.1 0.098 12.0 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CRG89473.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.5 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ECH_1 PF00378.20 CRG89474.1 - 6.4e-39 133.8 0.0 8.8e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG89474.1 - 3.8e-21 75.9 0.0 4.8e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase BTB PF00651.31 CRG89475.1 - 0.075 13.3 0.0 0.092 13.0 0.0 1.2 1 0 0 1 1 1 0 BTB/POZ domain GFO_IDH_MocA PF01408.22 CRG89476.1 - 6.1e-14 52.9 0.1 1.3e-13 51.8 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG89476.1 - 0.00016 21.7 0.0 0.0003 20.8 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Acyl_transf_3 PF01757.22 CRG89478.1 - 4e-32 111.6 34.2 7.5e-32 110.7 34.2 1.4 1 0 0 1 1 1 1 Acyltransferase family HAD_2 PF13419.6 CRG89478.1 - 4.2e-17 62.8 0.0 6.8e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG89478.1 - 3.6e-05 24.1 0.0 0.0025 18.1 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 CRG89478.1 - 0.015 15.7 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Gly_transf_sug PF04488.15 CRG89479.1 - 5.7e-12 46.1 0.1 1.5e-11 44.7 0.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TauD PF02668.16 CRG89480.1 - 1.2e-33 117.1 0.1 1.5e-33 116.8 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DPRP PF04244.13 CRG89480.1 - 0.042 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Deoxyribodipyrimidine photo-lyase-related protein DUF3830 PF12903.7 CRG89481.1 - 1e-27 96.6 0.0 1.1e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3830) MFS_1 PF07690.16 CRG89482.1 - 1.5e-20 73.4 24.9 4.6e-14 52.1 6.0 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG89482.1 - 5.8e-05 22.1 3.3 0.0033 16.3 7.1 1.9 1 1 0 2 2 2 1 MFS_1 like family Zn_clus PF00172.18 CRG89482.1 - 0.00092 19.3 8.2 0.0017 18.4 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG89482.1 - 0.012 14.6 0.3 0.066 12.2 0.1 2.3 2 0 0 2 2 2 0 Fungal specific transcription factor domain Rootletin PF15035.6 CRG89482.1 - 0.2 11.7 0.0 0.2 11.7 0.0 1.6 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion AA_permease PF00324.21 CRG89483.1 - 1.5e-99 333.8 44.9 1.4e-98 330.6 44.9 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG89483.1 - 3.9e-23 82.0 41.3 4.4e-22 78.5 41.3 2.0 1 1 0 1 1 1 1 Amino acid permease DUF4231 PF14015.6 CRG89483.1 - 0.11 13.0 3.1 3.1 8.3 0.0 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DHDPS PF00701.22 CRG89484.1 - 5.5e-34 117.2 0.0 7.6e-34 116.7 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family CorA PF01544.18 CRG89485.1 - 6.7e-13 48.6 0.1 1.4e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein CagE_TrbE_VirB PF03135.14 CRG89485.1 - 0.035 14.2 0.3 0.058 13.5 0.3 1.2 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system DUF365 PF04033.12 CRG89485.1 - 0.23 11.8 1.5 0.35 11.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF365) Sugar_tr PF00083.24 CRG89486.1 - 4e-76 256.7 17.7 5e-76 256.4 17.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89486.1 - 1.3e-15 57.3 33.3 2.4e-15 56.3 25.6 2.9 1 1 2 3 3 3 3 Major Facilitator Superfamily DUF4381 PF14316.6 CRG89486.1 - 0.3 11.3 3.7 0.74 10.0 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3792 PF12670.7 CRG89486.1 - 0.37 11.0 19.8 0.3 11.2 1.5 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3792) adh_short PF00106.25 CRG89487.1 - 7.8e-21 74.4 0.0 8.9e-16 57.9 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CRG89487.1 - 3.6e-09 36.8 0.0 6.6e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG89487.1 - 2e-08 34.1 0.0 2.4e-07 30.5 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 CRG89487.1 - 0.0024 17.1 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CRG89487.1 - 0.038 13.4 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG89487.1 - 0.14 11.3 0.0 0.29 10.2 0.0 1.5 2 0 0 2 2 2 0 Male sterility protein adh_short_C2 PF13561.6 CRG89488.1 - 2.1e-55 187.8 1.6 2.6e-55 187.5 1.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89488.1 - 7.2e-42 143.1 1.2 9.5e-42 142.7 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89488.1 - 1.9e-12 47.5 1.2 4.2e-12 46.4 1.2 1.6 1 1 0 1 1 1 1 KR domain NAD_binding_2 PF03446.15 CRG89488.1 - 0.031 14.4 0.2 0.058 13.6 0.2 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase RmlD_sub_bind PF04321.17 CRG89488.1 - 0.11 11.6 1.5 3.5 6.6 0.0 2.6 2 1 0 2 2 2 0 RmlD substrate binding domain ADH_N PF08240.12 CRG89489.1 - 2.8e-31 107.6 0.7 2.8e-31 107.6 0.7 2.2 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89489.1 - 2.6e-23 82.4 0.5 5.6e-23 81.3 0.5 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG89489.1 - 8e-08 32.0 0.7 1.7e-06 27.7 0.7 2.2 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CRG89489.1 - 6.5e-06 27.2 0.1 3.8e-05 24.7 0.1 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 CRG89489.1 - 0.00017 22.2 0.0 0.00037 21.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CRG89489.1 - 0.00017 21.0 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase 2-Hacid_dh_C PF02826.19 CRG89489.1 - 0.008 15.6 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_11 PF08241.12 CRG89489.1 - 0.012 16.2 0.0 0.026 15.2 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain UDPG_MGDP_dh_N PF03721.14 CRG89489.1 - 0.03 13.9 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_31 PF13847.6 CRG89489.1 - 0.051 13.4 0.2 0.28 11.0 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89489.1 - 0.13 13.0 0.0 0.29 11.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain AAA_33 PF13671.6 CRG89490.1 - 5.7e-05 23.3 0.0 0.00015 22.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain PRK PF00485.18 CRG89490.1 - 8.1e-05 22.5 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CRG89490.1 - 0.00058 20.4 0.0 0.0011 19.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 CRG89490.1 - 0.00078 18.8 0.1 0.0017 17.7 0.1 1.6 2 0 0 2 2 2 1 Zeta toxin NB-ARC PF00931.22 CRG89490.1 - 0.0011 18.2 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 CRG89490.1 - 0.0012 19.3 0.0 0.002 18.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG89490.1 - 0.0052 17.1 0.0 0.026 14.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CRG89490.1 - 0.0069 16.8 0.1 0.015 15.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 CRG89490.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 NTPase KTI12 PF08433.10 CRG89490.1 - 0.011 15.2 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_5 PF07728.14 CRG89490.1 - 0.013 15.5 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Cytidylate_kin PF02224.18 CRG89490.1 - 0.016 15.0 0.3 0.025 14.3 0.3 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_16 PF13191.6 CRG89490.1 - 0.025 15.0 0.0 0.042 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_PrkA PF08298.11 CRG89490.1 - 0.026 13.4 0.0 0.037 13.0 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain NACHT PF05729.12 CRG89490.1 - 0.041 13.8 0.0 0.065 13.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.6 CRG89490.1 - 0.045 13.5 0.1 0.082 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 CRG89490.1 - 0.051 13.6 0.0 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 CRG89490.1 - 0.054 12.9 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_29 PF13555.6 CRG89490.1 - 0.059 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 CRG89490.1 - 0.07 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 CRG89490.1 - 0.078 12.5 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CRG89490.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 CRG89490.1 - 0.19 10.8 0.1 0.36 9.8 0.0 1.5 1 1 1 2 2 2 0 Type II/IV secretion system protein adh_short_C2 PF13561.6 CRG89491.1 - 1e-56 192.1 0.0 1.2e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89491.1 - 3e-40 137.8 0.1 3.9e-40 137.4 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89491.1 - 4.7e-10 39.7 0.3 7.5e-10 39.0 0.3 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG89491.1 - 0.015 14.8 0.2 0.019 14.5 0.2 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CRG89491.1 - 0.068 12.3 0.0 0.091 11.9 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CRG89491.1 - 0.13 11.6 0.6 0.19 11.1 0.1 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CRG89491.1 - 0.14 12.4 0.1 0.32 11.3 0.1 1.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 CRG89491.1 - 0.15 12.6 0.1 0.26 11.8 0.1 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 CRG89491.1 - 0.15 11.4 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CRG89492.1 - 2.4e-22 79.2 0.4 5e-22 78.2 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Clathrin-link PF09268.10 CRG89492.1 - 4.9 6.6 4.9 29 4.2 1.6 2.6 2 0 0 2 2 2 0 Clathrin, heavy-chain linker Glyco_hydro_64 PF16483.5 CRG89493.1 - 7.8e-119 397.2 0.3 9e-119 397.0 0.3 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase IU_nuc_hydro PF01156.19 CRG89494.1 - 0.12 12.0 0.2 0.14 11.7 0.2 1.1 1 0 0 1 1 1 0 Inosine-uridine preferring nucleoside hydrolase DUF3342 PF11822.8 CRG89495.1 - 0.14 12.4 0.2 27 5.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3342) CENP-Q PF13094.6 CRG89495.1 - 7.1 6.8 7.8 4.9 7.3 1.7 3.0 4 0 0 4 4 4 0 CENP-Q, a CENPA-CAD centromere complex subunit tRNA-synt_2b PF00587.25 CRG89496.1 - 6.7e-33 114.2 0.0 1.1e-32 113.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 CRG89496.1 - 9.9e-08 32.0 0.0 2.5e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain Fungal_trans PF04082.18 CRG89497.1 - 7.5e-27 94.0 0.1 1.2e-26 93.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89497.1 - 4.5e-10 39.5 6.7 7.6e-10 38.8 6.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugarporin_N PF11471.8 CRG89497.1 - 0.017 15.1 0.1 0.048 13.6 0.1 1.8 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Pex14_N PF04695.13 CRG89497.1 - 3.6 8.2 6.2 11 6.6 6.2 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NmrA PF05368.13 CRG89498.1 - 1.5e-32 113.0 0.0 1.9e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG89498.1 - 5.3e-07 29.7 0.0 7.2e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG89498.1 - 0.055 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family AATase PF07247.12 CRG89499.1 - 5e-21 74.8 0.0 1.7e-20 73.1 0.0 1.7 1 1 0 1 1 1 1 Alcohol acetyltransferase WES_acyltransf PF03007.16 CRG89499.1 - 1.8e-05 24.6 0.0 7.4e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain Condensation PF00668.20 CRG89499.1 - 0.0024 16.6 0.3 0.0062 15.3 0.1 1.6 2 0 0 2 2 2 1 Condensation domain Transferase PF02458.15 CRG89499.1 - 0.067 11.8 0.0 0.12 11.0 0.0 1.3 1 0 0 1 1 1 0 Transferase family Glyco_hydr_30_2 PF14587.6 CRG89500.1 - 6.1e-12 45.8 0.1 7.9e-09 35.6 0.0 2.6 2 1 0 3 3 3 2 O-Glycosyl hydrolase family 30 Glyco_hydro_30C PF17189.4 CRG89500.1 - 5.4e-11 42.5 1.6 1.7e-10 41.0 1.6 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain Glyco_hydro_30 PF02055.16 CRG89500.1 - 4.7e-09 35.7 0.4 8.1e-09 34.9 0.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 CRG89500.1 - 5.6e-08 32.4 0.1 9.2e-08 31.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_43 PF04616.14 CRG89501.1 - 6e-105 350.7 0.3 4e-103 344.7 0.1 2.1 2 0 0 2 2 2 2 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CRG89501.1 - 7.4e-44 149.9 0.0 1.1e-43 149.3 0.0 1.3 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain Glyco_hydro_32N PF00251.20 CRG89501.1 - 0.047 13.3 0.3 0.18 11.3 0.0 2.0 2 1 1 3 3 3 0 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_67M PF07488.12 CRG89502.1 - 4.3e-137 456.5 0.0 5.9e-137 456.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 CRG89502.1 - 2.7e-85 285.4 1.2 4.6e-85 284.7 1.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus Glyco_hydro_67N PF03648.14 CRG89502.1 - 4.6e-27 94.7 0.0 7.2e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 N-terminus Glyco_hydro_20b PF02838.15 CRG89502.1 - 0.001 19.8 0.0 0.002 18.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Qua1 PF16274.5 CRG89502.1 - 0.077 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Qua1 domain DUF2135 PF09906.9 CRG89502.1 - 0.39 11.0 1.3 0.93 9.8 1.3 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2135) Sugar_tr PF00083.24 CRG89503.1 - 4.5e-85 286.2 17.9 5.2e-85 286.0 17.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89503.1 - 9e-18 64.3 43.7 4.2e-15 55.5 27.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Lipase_GDSL_2 PF13472.6 CRG89504.1 - 1.6e-18 67.7 0.6 2.2e-18 67.3 0.6 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG89504.1 - 7.3e-07 29.4 0.1 1.1e-06 28.7 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase NAD_binding_10 PF13460.6 CRG89505.1 - 3.2e-09 36.9 0.0 3.9e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG89505.1 - 6.5e-05 22.5 0.0 0.00082 18.9 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG89505.1 - 0.00043 19.4 0.0 0.00059 18.9 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 CRG89505.1 - 0.0019 18.3 0.0 0.0034 17.5 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_4 PF07993.12 CRG89505.1 - 0.0033 16.6 0.0 0.017 14.3 0.0 2.1 1 1 0 2 2 2 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 CRG89505.1 - 0.011 16.0 0.0 0.022 15.0 0.0 1.6 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 CRG89505.1 - 0.028 14.8 0.0 0.066 13.6 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Glyco_hydro_47 PF01532.20 CRG89506.1 - 9.7e-108 361.0 0.0 1.1e-107 360.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF1445 PF07286.12 CRG89507.1 - 5.2e-60 201.5 0.0 1.1e-59 200.5 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1445) p450 PF00067.22 CRG89508.1 - 3.2e-74 250.3 0.0 4.2e-74 250.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Glyco_transf_28 PF03033.20 CRG89509.1 - 5.6e-19 68.6 0.4 7.2e-12 45.5 0.1 2.5 2 0 0 2 2 2 2 Glycosyltransferase family 28 N-terminal domain ATG_C PF09333.11 CRG89509.1 - 6.5e-06 26.4 0.0 1.6e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain UDPGT PF00201.18 CRG89509.1 - 1.6e-05 24.0 0.0 2.6e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CRG89509.1 - 0.041 13.9 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain UIM PF02809.20 CRG89509.1 - 0.075 13.0 4.9 0.064 13.2 0.8 2.9 2 0 0 2 2 2 0 Ubiquitin interaction motif ADH_N PF08240.12 CRG89510.1 - 4.6e-28 97.3 1.2 1.2e-27 96.0 1.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89510.1 - 4.9e-13 49.2 0.0 7.6e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG89510.1 - 7.8e-05 22.3 2.2 0.019 14.5 1.2 3.1 2 1 0 2 2 2 2 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 CRG89510.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Glyco_hydro_16 PF00722.21 CRG89512.1 - 2.9e-43 147.4 3.1 4.9e-43 146.6 3.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 AMP-binding PF00501.28 CRG89513.1 - 4e-19 68.5 0.0 6.4e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG89513.1 - 2.4e-11 44.4 0.0 5e-11 43.4 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans_2 PF11951.8 CRG89513.1 - 0.035 12.9 0.4 0.066 12.0 0.2 1.5 2 0 0 2 2 2 0 Fungal specific transcription factor domain ATP-synt_G PF04718.15 CRG89514.1 - 5.3e-35 120.2 0.1 9.9e-35 119.4 0.0 1.4 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit Phage_holin_2_1 PF04971.12 CRG89514.1 - 0.17 11.9 0.4 0.3 11.1 0.1 1.6 2 0 0 2 2 2 0 Bacteriophage P21 holin S DEAD PF00270.29 CRG89515.1 - 3.9e-25 88.6 0.0 3.9e-14 52.8 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG89515.1 - 8.2e-23 80.9 0.0 2.2e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG89515.1 - 3.7e-06 27.1 0.0 3.5e-05 23.9 0.0 2.5 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 CRG89515.1 - 0.0073 15.1 0.0 0.011 14.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Vps39_1 PF10366.9 CRG89517.1 - 0.091 13.0 3.0 1.2 9.4 0.0 3.1 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 TPR_12 PF13424.6 CRG89517.1 - 0.2 12.0 1.5 0.58 10.5 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_16 PF10294.9 CRG89518.1 - 1.4e-20 73.7 0.0 2.6e-20 72.8 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 CRG89518.1 - 0.0064 16.3 0.0 0.014 15.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain VPS28 PF03997.12 CRG89519.1 - 7.4e-72 241.0 0.0 8.7e-72 240.8 0.0 1.0 1 0 0 1 1 1 1 VPS28 protein Noc2 PF03715.13 CRG89520.1 - 1.3e-127 425.1 0.0 3.7e-127 423.7 0.0 1.8 2 0 0 2 2 2 1 Noc2p family TrkH PF02386.16 CRG89521.1 - 5.3e-87 292.4 9.0 1.3e-85 287.8 2.6 2.5 2 1 0 2 2 2 2 Cation transport protein Glyco_hydro_18 PF00704.28 CRG89522.1 - 1.6e-69 235.0 1.7 1.9e-69 234.8 1.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 FAD_binding_1 PF00667.20 CRG89523.1 - 8.8e-52 175.9 0.0 1.5e-51 175.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CRG89523.1 - 5.1e-24 85.1 0.1 8.5e-24 84.4 0.1 1.4 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 CRG89523.1 - 7.4e-20 71.6 0.0 1.5e-19 70.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain GGDEF_2 PF17853.1 CRG89523.1 - 0.0056 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 GGDEF-like domain GFO_IDH_MocA PF01408.22 CRG89524.1 - 1.2e-23 84.2 0.1 2.6e-23 83.1 0.1 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG89524.1 - 6.9e-06 26.1 0.0 1.3e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Fungal_trans_2 PF11951.8 CRG89525.1 - 3.2e-08 32.8 0.0 2.3e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89525.1 - 0.1 12.7 1.3 0.24 11.6 1.3 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 CRG89526.1 - 2.3e-60 204.7 0.0 4.5e-60 203.7 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Glyco_hydro_18 PF00704.28 CRG89528.1 - 8.9e-23 81.5 1.9 1.8e-22 80.5 1.9 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 NAD_binding_7 PF13241.6 CRG89529.1 - 0.11 13.0 0.1 18 5.8 0.0 2.4 2 1 0 2 2 2 0 Putative NAD(P)-binding MoaC PF01967.21 CRG89530.1 - 1.7e-45 154.4 1.0 1.7e-45 154.4 1.0 2.2 2 0 0 2 2 2 1 MoaC family ABC_tran PF00005.27 CRG89530.1 - 3.5e-42 144.2 0.1 2.9e-21 76.4 0.0 3.7 2 1 0 2 2 2 2 ABC transporter Mob_synth_C PF06463.13 CRG89530.1 - 3.9e-36 123.8 0.0 2.4e-35 121.3 0.0 2.3 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 CRG89530.1 - 6e-27 95.1 0.1 1.3e-26 94.0 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily AAA_21 PF13304.6 CRG89530.1 - 3.2e-13 50.2 3.4 0.0094 15.8 0.5 4.5 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG89530.1 - 4.1e-10 39.5 3.1 0.0061 16.0 0.0 4.4 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_tran_Xtn PF12848.7 CRG89530.1 - 9.1e-08 32.0 3.4 3.3e-07 30.2 3.4 2.0 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 CRG89530.1 - 3.2e-06 27.2 0.1 0.068 13.3 0.0 3.3 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CRG89530.1 - 3.9e-06 26.5 0.6 0.022 14.5 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG89530.1 - 6.3e-06 26.8 6.0 0.015 15.8 3.2 3.0 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG89530.1 - 4.7e-05 23.8 0.1 0.064 13.6 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 CRG89530.1 - 0.00039 20.2 0.2 0.23 11.1 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain Fer4_12 PF13353.6 CRG89530.1 - 0.00068 19.9 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain AAA_33 PF13671.6 CRG89530.1 - 0.00094 19.4 0.7 6.8 6.8 0.0 4.0 4 0 0 4 4 4 0 AAA domain AAA_18 PF13238.6 CRG89530.1 - 0.0012 19.4 0.2 2.4 8.7 0.1 3.1 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CRG89530.1 - 0.0057 16.6 0.3 2.3 8.1 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 CRG89530.1 - 0.0057 16.9 0.1 2.9 8.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG89530.1 - 0.0066 16.7 4.1 2.5 8.4 0.1 3.7 4 1 0 4 4 3 2 AAA domain AAA_30 PF13604.6 CRG89530.1 - 0.0079 15.9 0.2 2 8.1 0.0 3.6 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CRG89530.1 - 0.011 16.2 0.1 9.7 6.6 0.0 3.5 3 0 0 3 3 3 0 RNA helicase AAA_7 PF12775.7 CRG89530.1 - 0.026 14.0 0.4 0.59 9.6 0.0 2.8 3 0 0 3 3 3 0 P-loop containing dynein motor region AAA PF00004.29 CRG89530.1 - 0.037 14.5 0.1 0.89 10.0 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 CRG89530.1 - 0.04 13.1 0.2 6.6 5.8 0.0 2.6 2 0 0 2 2 2 0 NB-ARC domain AAA_14 PF13173.6 CRG89530.1 - 0.043 13.9 2.3 17 5.5 0.2 3.6 4 0 0 4 4 3 0 AAA domain AAA_5 PF07728.14 CRG89530.1 - 0.053 13.5 0.3 1.3 9.0 0.0 3.0 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 CRG89530.1 - 0.078 12.6 0.0 0.54 9.9 0.0 2.1 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MeaB PF03308.16 CRG89530.1 - 0.38 9.7 5.3 3.8 6.4 0.1 3.0 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NACHT PF05729.12 CRG89530.1 - 0.79 9.6 3.9 15 5.4 0.2 3.0 3 0 0 3 3 3 0 NACHT domain BTB PF00651.31 CRG89531.1 - 3.7e-15 56.1 0.0 4.5e-14 52.6 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain Vps39_2 PF10367.9 CRG89531.1 - 0.013 16.0 0.4 0.034 14.6 0.4 1.7 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 BTB_2 PF02214.22 CRG89531.1 - 0.035 14.5 0.0 0.081 13.3 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain Acetyltransf_3 PF13302.7 CRG89532.1 - 1.3e-15 58.2 0.0 2e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG89532.1 - 3.7e-08 33.6 0.0 6.3e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family DUF4880 PF16220.5 CRG89532.1 - 0.012 15.5 1.2 0.03 14.2 1.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) Acetyltransf_4 PF13420.7 CRG89532.1 - 0.049 13.8 0.0 0.068 13.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Lactamase_B_4 PF13691.6 CRG89533.1 - 5.7e-19 67.6 0.1 3.4e-18 65.1 0.0 2.3 2 0 0 2 2 2 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 CRG89533.1 - 1.6e-10 40.8 0.0 7.1e-05 22.4 0.0 2.6 2 0 0 2 2 2 2 Beta-lactamase superfamily domain bZIP_1 PF00170.21 CRG89533.1 - 4e-07 30.0 9.4 4e-07 30.0 9.4 2.9 2 0 0 2 2 2 1 bZIP transcription factor Lactamase_B PF00753.27 CRG89533.1 - 0.095 12.7 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily PilO PF04350.13 CRG89533.1 - 3.5 7.8 8.1 4.2 7.5 5.0 2.7 2 0 0 2 2 2 0 Pilus assembly protein, PilO DSBA PF01323.20 CRG89534.1 - 1.9e-28 99.5 0.0 2.4e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 CRG89535.1 - 1.1e-29 103.3 0.0 1.5e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89535.1 - 8.9e-17 61.4 0.0 1.2e-16 61.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89535.1 - 3e-06 27.3 0.0 7.7e-06 25.9 0.0 1.6 1 1 1 2 2 2 1 KR domain DUF1776 PF08643.10 CRG89535.1 - 7.9e-05 22.2 0.0 0.00023 20.6 0.0 1.6 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Glyco_tran_WecB PF03808.13 CRG89535.1 - 0.0082 16.1 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase WecB/TagA/CpsF family His_Phos_2 PF00328.22 CRG89536.1 - 5.7e-17 62.1 0.0 6.1e-16 58.7 0.0 2.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) LysM PF01476.20 CRG89537.1 - 6.8e-11 42.1 0.0 0.00059 19.8 0.0 3.4 3 0 0 3 3 3 3 LysM domain TMEM174 PF15029.6 CRG89537.1 - 0.092 12.5 4.4 2.9 7.6 0.3 2.5 3 0 0 3 3 3 0 Transmembrane protein 174 ETF_alpha PF00766.19 CRG89537.1 - 0.099 12.7 0.0 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Electron transfer flavoprotein FAD-binding domain Dus PF01207.17 CRG89538.1 - 4.4e-59 200.1 0.0 1.2e-58 198.7 0.0 1.7 2 1 1 3 3 3 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 CRG89538.1 - 0.0013 18.0 0.0 0.0022 17.3 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase tRNA_anti-like PF12869.7 CRG89538.1 - 0.78 9.3 0.0 0.78 9.3 0.0 2.1 3 0 0 3 3 3 0 tRNA_anti-like ANAPC4_WD40 PF12894.7 CRG89539.1 - 3.4e-07 30.5 0.4 0.34 11.2 0.0 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG89539.1 - 0.00047 20.9 1.4 13 6.8 0.0 5.9 6 0 0 6 6 6 1 WD domain, G-beta repeat IKI3 PF04762.12 CRG89539.1 - 0.0033 15.5 0.0 0.058 11.4 0.0 2.1 2 0 0 2 2 2 1 IKI3 family PD40 PF07676.12 CRG89539.1 - 1.3 9.1 3.5 0.71 9.9 0.1 2.4 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat adh_short PF00106.25 CRG89540.1 - 1.5e-39 135.5 0.1 2.1e-39 135.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89540.1 - 1.9e-30 106.1 0.0 2.5e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CRG89540.1 - 4.8e-06 26.6 0.1 7.4e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CRG89540.1 - 1.9e-05 24.7 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 KR domain DFP PF04127.15 CRG89540.1 - 0.015 15.1 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein RmlD_sub_bind PF04321.17 CRG89540.1 - 0.065 12.3 0.0 0.09 11.9 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Ribosomal_S25 PF03297.15 CRG89541.1 - 1.2e-39 134.5 4.5 1.4e-39 134.4 4.5 1.0 1 0 0 1 1 1 1 S25 ribosomal protein MarR_2 PF12802.7 CRG89541.1 - 0.001 18.9 0.1 0.0012 18.6 0.1 1.2 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.20 CRG89541.1 - 0.0024 18.2 0.1 0.0037 17.6 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator HTH_DeoR PF08220.12 CRG89541.1 - 0.0025 17.5 0.1 0.0035 17.0 0.1 1.2 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_24 PF13412.6 CRG89541.1 - 0.0085 15.6 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 CRG89541.1 - 0.0099 15.7 0.3 0.012 15.5 0.3 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB EAP30 PF04157.16 CRG89541.1 - 0.019 14.3 0.1 0.022 14.0 0.1 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family GntR PF00392.21 CRG89541.1 - 0.021 14.5 0.1 0.031 13.9 0.1 1.2 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family Cyt-b5 PF00173.28 CRG89542.1 - 5.2e-08 32.9 0.0 8.8e-08 32.2 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Orf78 PF06024.12 CRG89542.1 - 0.16 12.2 0.2 0.78 10.1 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) U1snRNP70_N PF12220.8 CRG89542.1 - 3.1 8.5 6.5 1.6 9.4 0.2 2.3 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Gtr1_RagA PF04670.12 CRG89543.1 - 9.2e-67 224.8 0.2 1.9e-66 223.7 0.2 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Aminotran_5 PF00266.19 CRG89543.1 - 1.3e-26 93.4 0.0 8.1e-18 64.5 0.0 2.1 1 1 1 2 2 2 2 Aminotransferase class-V Arf PF00025.21 CRG89543.1 - 0.00022 20.7 0.0 0.00049 19.6 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_14 PF13173.6 CRG89543.1 - 0.033 14.2 0.0 2 8.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 CRG89543.1 - 0.049 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CRG89543.1 - 0.061 13.4 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG89543.1 - 0.083 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 CRG89543.1 - 0.13 12.6 0.1 1.4 9.3 0.0 2.5 2 1 0 2 2 2 0 AAA ATPase domain DUF1479 PF07350.12 CRG89544.1 - 1.8e-142 475.0 0.0 2.1e-142 474.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 CRG89544.1 - 0.0054 17.0 0.1 0.063 13.5 0.1 2.4 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Inositol_P PF00459.25 CRG89546.1 - 2.9e-78 263.1 0.0 3.3e-78 262.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family LCM PF04072.14 CRG89547.1 - 6.2e-20 71.9 0.0 1.8e-18 67.1 0.0 2.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Nod1 PF17114.5 CRG89547.1 - 0.036 14.2 0.2 0.23 11.6 0.0 2.4 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 DEAD_2 PF06733.15 CRG89548.1 - 4.8e-51 172.9 0.5 2.7e-50 170.4 0.1 2.2 2 0 0 2 2 2 1 DEAD_2 HBB PF06777.11 CRG89548.1 - 1e-44 152.5 2.8 8.2e-41 139.8 0.8 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 CRG89548.1 - 4.8e-43 147.3 0.0 1e-42 146.2 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain RNA_pol_Rpb1_5 PF04998.17 CRG89549.1 - 2.3e-77 260.1 0.1 4.1e-77 259.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 CRG89549.1 - 5.3e-63 212.2 0.1 9.9e-63 211.3 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 CRG89549.1 - 2.3e-38 131.6 0.0 3.8e-36 124.4 0.0 2.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 CRG89549.1 - 6.8e-25 88.0 0.9 4e-23 82.2 0.4 3.2 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 CRG89549.1 - 5.9e-17 61.6 0.0 2.8e-16 59.4 0.0 2.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 PRP3 PF08572.10 CRG89550.1 - 1.6e-71 240.6 6.1 1.6e-71 240.6 6.1 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 CRG89550.1 - 7.6e-48 162.3 0.1 7.6e-48 162.3 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Gar1 PF04410.14 CRG89551.1 - 8.1e-48 162.1 0.6 8.1e-48 162.1 0.6 2.1 3 0 0 3 3 3 1 Gar1/Naf1 RNA binding region Cwf_Cwc_15 PF04889.12 CRG89551.1 - 1.4 8.6 27.3 0.085 12.6 13.7 2.9 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Exo5 PF09810.9 CRG89552.1 - 2.3e-139 465.0 0.1 4.8e-139 463.9 0.0 1.5 2 0 0 2 2 2 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 CRG89552.1 - 0.00015 21.8 0.3 0.2 11.6 0.0 3.4 2 1 0 2 2 2 2 PD-(D/E)XK nuclease superfamily DUF3678 PF12435.8 CRG89552.1 - 0.025 14.0 0.3 0.058 12.8 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) DUF3799 PF12684.7 CRG89552.1 - 0.05 13.4 0.0 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 PDDEXK-like domain of unknown function (DUF3799) ACT_3 PF10000.9 CRG89553.1 - 7e-23 80.3 0.1 1.3e-22 79.5 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_7 PF13840.6 CRG89553.1 - 5.6e-12 45.3 0.0 8.3e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 ACT domain Mpv17_PMP22 PF04117.12 CRG89554.1 - 6.8e-17 61.5 0.6 1.6e-16 60.2 0.6 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family MFS_1 PF07690.16 CRG89555.1 - 2.1e-39 135.4 52.1 2e-37 129.0 52.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89555.1 - 9.6e-06 24.7 19.5 9.6e-06 24.7 19.5 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter CK1gamma_C PF12605.8 CRG89555.1 - 0.14 13.3 2.1 0.28 12.4 2.1 1.4 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal Zn_clus PF00172.18 CRG89556.1 - 1.1e-08 35.1 8.1 1.9e-08 34.3 8.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG89556.1 - 1.7e-07 30.4 0.1 1.1e-05 24.5 0.0 2.4 2 1 0 2 2 2 2 Fungal specific transcription factor domain BTAD PF03704.17 CRG89556.1 - 0.061 13.7 0.5 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial transcriptional activator domain DUF3130 PF11328.8 CRG89556.1 - 0.16 12.2 0.0 1.9 8.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3130 RTA1 PF04479.13 CRG89557.1 - 3.1e-54 183.7 2.4 3.1e-54 183.7 2.4 1.6 1 1 1 2 2 2 1 RTA1 like protein HisKA_7TM PF16927.5 CRG89557.1 - 0.0089 16.1 9.9 0.0089 16.1 9.9 2.2 1 1 0 2 2 2 1 N-terminal 7TM region of histidine kinase DUF373 PF04123.13 CRG89557.1 - 0.15 11.5 4.5 0.097 12.1 2.3 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF373) 7tm_1 PF00001.21 CRG89557.1 - 1.4 8.2 5.8 0.53 9.6 2.4 2.0 1 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) MpPF26 PF07666.11 CRG89557.1 - 6.5 6.9 8.6 7.7 6.6 0.2 3.1 3 0 0 3 3 3 0 M penetrans paralogue family 26 Histone PF00125.24 CRG89558.1 - 1e-51 174.7 2.5 1.1e-51 174.6 2.5 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 CRG89558.1 - 6e-06 26.6 0.0 9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CRG89558.1 - 4.9e-05 23.4 0.5 7.4e-05 22.8 0.1 1.5 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 CRG89558.1 - 6.5e-05 23.5 1.2 7.7e-05 23.3 1.2 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 CRG89558.1 - 0.0032 17.7 0.3 0.0065 16.7 0.0 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 CRG89558.1 - 0.026 14.6 0.2 0.042 13.9 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 CRG89559.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 CRG89559.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 CRG89559.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 CRG89559.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 CRG89559.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 CRG89559.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 CRG89559.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 CRG89559.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 CRG89559.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region zf-C2H2 PF00096.26 CRG89560.1 - 2.2e-10 40.4 14.8 0.00017 21.8 1.5 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG89560.1 - 6.4e-06 26.6 11.4 0.029 15.2 1.0 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger DUF2486 PF10667.9 CRG89560.1 - 0.14 12.4 8.4 0.53 10.5 8.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) zf-BED PF02892.15 CRG89560.1 - 0.27 11.3 1.8 1 9.4 1.8 2.0 1 0 0 1 1 1 0 BED zinc finger zf-Di19 PF05605.12 CRG89560.1 - 0.8 10.0 6.5 1 9.7 1.4 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 CRG89560.1 - 3.7 8.2 10.4 15 6.2 0.9 3.9 4 0 0 4 4 4 0 Zinc-finger double domain EPSP_synthase PF00275.20 CRG89561.1 - 1.4e-125 419.3 0.0 2.1e-125 418.7 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 CRG89561.1 - 3.9e-100 334.3 0.0 6.7e-100 333.6 0.0 1.4 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 CRG89561.1 - 1.1e-56 192.7 0.0 3.1e-56 191.2 0.0 1.8 2 0 0 2 2 1 1 Type I 3-dehydroquinase SKI PF01202.22 CRG89561.1 - 2e-39 135.3 0.0 4.8e-37 127.5 0.0 2.5 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 CRG89561.1 - 2.2e-23 82.3 0.0 5.6e-23 81.0 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 CRG89561.1 - 1.1e-08 34.7 0.1 5e-08 32.6 0.0 2.2 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 CRG89561.1 - 2.2e-07 30.8 0.0 8e-07 29.0 0.0 1.9 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 CRG89561.1 - 0.0031 17.6 0.0 0.0099 15.9 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_16 PF13191.6 CRG89561.1 - 0.0051 17.2 0.3 0.14 12.5 0.0 3.1 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 CRG89561.1 - 0.031 14.6 0.0 0.15 12.3 0.0 2.2 1 0 0 1 1 1 0 AAA domain Sacchrp_dh_NADP PF03435.18 CRG89561.1 - 0.078 13.2 0.0 3.7 7.8 0.0 2.7 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AAA PF00004.29 CRG89561.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CRG89561.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CRG89561.1 - 0.16 12.0 0.0 0.44 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain XRN_M PF17846.1 CRG89562.1 - 2e-144 481.8 5.5 2.3e-143 478.3 0.3 2.8 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 CRG89562.1 - 2.2e-99 331.8 3.2 3.7e-99 331.1 0.0 2.1 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus zf-CCHC PF00098.23 CRG89562.1 - 0.0068 16.4 1.7 0.0068 16.4 1.7 2.0 3 0 0 3 3 3 1 Zinc knuckle Uso1_p115_head PF04869.14 CRG89563.1 - 2.8e-111 371.6 0.0 6.8e-111 370.3 0.0 1.7 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 CRG89563.1 - 2.7e-15 56.9 43.7 2.7e-15 56.9 43.7 4.4 1 1 3 4 4 4 2 Uso1 / p115 like vesicle tethering protein, C terminal region Tropomyosin PF00261.20 CRG89563.1 - 0.0048 16.3 33.5 0.0048 16.3 33.5 3.5 2 1 2 4 4 4 2 Tropomyosin Spc7 PF08317.11 CRG89563.1 - 0.046 12.6 75.3 0.014 14.3 10.4 3.4 1 1 2 3 3 3 0 Spc7 kinetochore protein Filament PF00038.21 CRG89563.1 - 1.1 8.7 65.1 4.2 6.8 44.0 2.4 1 1 1 2 2 2 0 Intermediate filament protein tRNA-synt_1 PF00133.22 CRG89564.1 - 1.4e-223 743.5 0.0 2e-223 743.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CRG89564.1 - 1.6e-26 93.1 0.0 7e-26 91.0 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CRG89564.1 - 5.6e-13 48.4 0.0 2.4e-05 23.3 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 CRG89564.1 - 0.067 12.5 0.0 0.17 11.2 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 CRG89564.1 - 0.16 11.5 0.0 0.35 10.4 0.0 1.5 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 Sfi1 PF08457.10 CRG89565.1 - 2.2e-186 620.8 87.7 2.2e-186 620.8 87.7 2.1 1 1 1 2 2 2 2 Sfi1 spindle body protein Rav1p_C PF12234.8 CRG89566.1 - 7.7e-282 936.4 0.0 2e-281 935.0 0.0 1.7 2 0 0 2 2 2 1 RAVE protein 1 C terminal WD40 PF00400.32 CRG89566.1 - 0.0018 19.1 6.6 1.3 10.1 0.0 5.3 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG89566.1 - 0.0076 16.5 0.3 3.8 7.9 0.0 4.0 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain 2-Hacid_dh_C PF02826.19 CRG89568.1 - 8.3e-43 145.8 0.0 1.4e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG89568.1 - 3e-20 72.2 0.1 3.8e-20 71.9 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 CRG89568.1 - 4.1e-05 24.1 0.2 0.0001 22.8 0.2 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 CRG89568.1 - 0.0003 21.0 0.2 0.00056 20.1 0.2 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 CRG89568.1 - 0.00046 19.8 0.2 0.00097 18.7 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain XdhC_C PF13478.6 CRG89568.1 - 0.00067 20.2 0.0 0.0051 17.3 0.0 2.0 2 0 0 2 2 2 1 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 CRG89568.1 - 0.011 15.9 1.6 0.02 14.9 0.5 2.0 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Rossmann-like PF10727.9 CRG89568.1 - 0.03 14.2 0.1 0.083 12.8 0.1 1.8 1 0 0 1 1 1 0 Rossmann-like domain 3HCDH_N PF02737.18 CRG89568.1 - 0.052 13.4 0.1 0.085 12.7 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 CRG89568.1 - 0.087 13.3 0.2 0.42 11.1 0.0 2.1 2 1 0 2 2 2 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CRG89568.1 - 0.12 12.6 1.2 0.61 10.4 0.2 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain OPT PF03169.15 CRG89569.1 - 3.4e-159 531.4 16.9 4e-159 531.1 16.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF5383 PF17355.2 CRG89569.1 - 0.21 12.0 0.0 0.73 10.2 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5383) SH3_9 PF14604.6 CRG89570.1 - 4.7e-07 29.6 0.0 7.7e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 CRG89570.1 - 8.8e-05 22.7 7.1 8.8e-05 22.7 7.1 2.5 1 1 1 2 2 1 1 Podoplanin SH3_2 PF07653.17 CRG89570.1 - 0.00024 20.7 0.0 0.00061 19.4 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG89570.1 - 0.0026 17.3 0.0 0.0041 16.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain VSP PF03302.13 CRG89570.1 - 0.0045 15.9 11.6 0.0045 15.9 11.6 1.5 2 0 0 2 2 1 1 Giardia variant-specific surface protein EphA2_TM PF14575.6 CRG89570.1 - 0.006 17.4 0.1 0.2 12.6 0.0 2.7 3 0 0 3 3 2 1 Ephrin type-A receptor 2 transmembrane domain Stevor PF17410.2 CRG89570.1 - 0.0092 15.6 1.6 0.018 14.6 1.6 1.4 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame CYYR1 PF10873.8 CRG89570.1 - 1 9.8 0.0 1 9.8 0.0 3.6 4 1 0 4 4 2 0 Cysteine and tyrosine-rich protein 1 DUF4551 PF15087.6 CRG89570.1 - 1.9 7.2 6.3 3.7 6.3 6.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF2613 PF11021.8 CRG89570.1 - 3 8.0 23.5 0.69 10.1 0.3 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2613) CPSF100_C PF13299.6 CRG89570.1 - 5.9 7.1 7.9 68 3.6 7.1 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pkinase PF00069.25 CRG89571.1 - 6.3e-38 130.6 0.0 8.8e-38 130.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89571.1 - 1.8e-13 50.4 0.0 2.5e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CRG89571.1 - 0.00022 21.2 0.3 0.28 11.1 0.0 2.9 3 1 1 4 4 4 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG89571.1 - 0.016 14.0 0.0 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase KIX_2 PF16987.5 CRG89571.1 - 0.021 14.8 0.7 0.04 13.9 0.7 1.4 1 0 0 1 1 1 0 KIX domain ABC1 PF03109.16 CRG89571.1 - 0.13 12.4 0.1 0.85 9.8 0.0 2.1 2 0 0 2 2 2 0 ABC1 family muHD PF10291.9 CRG89572.1 - 2.5e-87 292.7 0.8 3.4e-87 292.2 0.8 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 CRG89572.1 - 1.8e-08 34.5 0.8 2.9e-07 30.7 0.0 3.2 4 0 0 4 4 4 1 Fes/CIP4, and EFC/F-BAR homology domain BAR PF03114.18 CRG89572.1 - 0.0047 16.6 3.4 0.0086 15.8 3.4 1.3 1 0 0 1 1 1 1 BAR domain IFT57 PF10498.9 CRG89572.1 - 2.2 7.2 8.7 0.079 11.9 2.6 1.6 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 MAD PF05557.13 CRG89573.1 - 9.1e-61 206.1 82.9 1.2e-52 179.2 83.1 2.5 2 1 1 3 3 3 3 Mitotic checkpoint protein FliD_C PF07195.12 CRG89573.1 - 0.0087 15.5 8.8 0.0087 15.5 8.8 4.6 5 1 0 5 5 5 1 Flagellar hook-associated protein 2 C-terminus DUF4156 PF13698.6 CRG89573.1 - 0.067 13.5 1.0 11 6.5 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4156) SLATT_6 PF18169.1 CRG89573.1 - 3.6 7.2 9.5 0.33 10.5 1.2 2.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 Ribosomal_L7Ae PF01248.26 CRG89574.1 - 3.9e-20 71.4 1.3 3.6e-19 68.3 1.3 2.3 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Colicin_Pyocin PF01320.18 CRG89574.1 - 0.0081 16.3 0.2 0.021 14.9 0.2 1.8 1 0 0 1 1 1 1 Colicin immunity protein / pyocin immunity protein MSC PF09402.10 CRG89574.1 - 0.018 14.5 0.8 0.026 14.0 0.8 1.3 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Pox_I6 PF04595.13 CRG89574.1 - 0.055 12.4 0.0 0.067 12.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus I6-like family Peptidase_M55 PF04951.13 CRG89574.1 - 0.081 12.3 0.7 2.8 7.3 0.1 2.2 1 1 1 2 2 2 0 D-aminopeptidase Ribosomal_L7Ae PF01248.26 CRG89575.1 - 1.6e-24 85.4 0.0 1.8e-24 85.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Oxidored_FMN PF00724.20 CRG89576.1 - 1.4e-58 198.8 0.0 8.9e-55 186.3 0.0 2.3 1 1 0 2 2 2 2 NADH:flavin oxidoreductase / NADH oxidase family DUF561 PF04481.12 CRG89576.1 - 0.095 11.9 0.2 1.1 8.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF561) HemY_N PF07219.13 CRG89577.1 - 0.00079 19.6 1.0 0.0019 18.4 1.0 1.5 1 0 0 1 1 1 1 HemY protein N-terminus SBF PF01758.16 CRG89581.1 - 5.6e-52 176.3 7.8 5.6e-52 176.3 7.8 2.0 2 2 0 2 2 2 1 Sodium Bile acid symporter family LMWPc PF01451.21 CRG89582.1 - 8.9e-23 81.2 0.0 1.2e-22 80.9 0.0 1.2 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase FMN_red PF03358.15 CRG89583.1 - 1.1e-22 80.5 0.0 1.5e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Methyltransf_31 PF13847.6 CRG89584.1 - 1.7e-30 105.8 0.0 2.4e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89584.1 - 4.5e-21 75.4 0.0 9.3e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89584.1 - 2.1e-18 66.7 0.0 5.5e-18 65.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG89584.1 - 3.5e-14 52.7 0.0 7.1e-14 51.7 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 CRG89584.1 - 6.8e-10 39.0 0.0 1e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89584.1 - 1.6e-09 38.3 0.0 3.3e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CRG89584.1 - 6.9e-08 32.2 0.2 1e-07 31.6 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 CRG89584.1 - 1e-06 28.7 0.0 1.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CRG89584.1 - 8.6e-05 22.1 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 CRG89584.1 - 0.00068 19.0 0.0 0.00098 18.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UPF0020 PF01170.18 CRG89584.1 - 0.0033 17.1 0.0 0.0057 16.4 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.15 CRG89584.1 - 0.0044 16.9 0.0 0.007 16.2 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase DOT1 PF08123.13 CRG89584.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 CRG89584.1 - 0.054 13.5 0.0 0.083 12.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 CRG89584.1 - 0.071 12.6 0.0 0.48 9.9 0.0 2.1 2 1 0 2 2 2 0 Putative methyltransferase GCD14 PF08704.10 CRG89584.1 - 0.078 12.6 0.0 0.99 9.0 0.0 2.1 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit HTH_9 PF08221.11 CRG89584.1 - 0.14 12.3 0.0 18 5.5 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DPBB_1 PF03330.18 CRG89585.1 - 2.3e-05 24.6 0.1 4.9e-05 23.5 0.1 1.6 1 1 0 1 1 1 1 Lytic transglycolase Glyco_hydro_45 PF02015.16 CRG89585.1 - 0.029 14.3 2.9 0.034 14.0 2.9 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 45 MFS_1 PF07690.16 CRG89586.1 - 1.1e-42 146.2 29.0 1.1e-42 146.2 29.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG89586.1 - 4.8e-11 42.2 23.4 9.3e-10 37.9 23.5 2.7 1 1 1 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG89586.1 - 5.7e-09 34.9 2.0 8.7e-09 34.3 2.0 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) T5orf172 PF10544.9 CRG89586.1 - 3.4e-06 27.5 0.4 2e-05 25.0 0.4 2.2 1 1 0 1 1 1 1 T5orf172 domain Ribonuc_L-PSP PF01042.21 CRG89586.1 - 1.4e-05 25.1 0.0 2.7e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP MUG113 PF13455.6 CRG89586.1 - 0.056 14.1 0.0 0.15 12.8 0.0 1.7 1 0 0 1 1 1 0 Meiotically up-regulated gene 113 DUF2304 PF10066.9 CRG89586.1 - 0.27 11.5 0.0 0.27 11.5 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) OATP PF03137.20 CRG89586.1 - 6.6 4.9 6.0 3.8 5.7 0.2 2.2 1 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family p450 PF00067.22 CRG89588.1 - 3.3e-51 174.5 0.0 5.3e-51 173.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 CRG89588.1 - 5.9e-14 52.2 0.0 3e-13 49.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89588.1 - 6.6e-11 42.8 0.0 9.3e-10 39.1 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89588.1 - 5.7e-08 33.3 0.0 3.3e-06 27.6 0.0 3.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89588.1 - 5.9e-06 26.9 0.0 5.5e-05 23.8 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89588.1 - 6.3e-06 26.1 0.0 6.1e-05 22.9 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain SET PF00856.28 CRG89588.1 - 0.0015 18.9 0.0 0.0032 17.9 0.0 1.7 1 0 0 1 1 1 1 SET domain Methyltransf_16 PF10294.9 CRG89588.1 - 0.0052 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CRG89588.1 - 0.011 15.3 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_2 PF00891.18 CRG89588.1 - 0.048 13.0 0.0 0.14 11.4 0.0 1.7 1 0 0 1 1 1 0 O-methyltransferase domain PrmA PF06325.13 CRG89588.1 - 0.062 12.7 0.2 0.14 11.5 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Fungal_trans PF04082.18 CRG89589.1 - 1.3e-35 122.7 0.0 2.5e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89589.1 - 6e-08 32.7 14.7 9.5e-08 32.1 14.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain bZIP_1 PF00170.21 CRG89589.1 - 0.068 13.3 0.3 0.23 11.6 0.3 1.9 1 0 0 1 1 1 0 bZIP transcription factor Transketolase_N PF00456.21 CRG89590.1 - 8.3e-153 508.2 0.1 1.1e-152 507.9 0.1 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 CRG89590.1 - 1.7e-42 145.1 0.0 2.9e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 CRG89590.1 - 3.8e-10 39.7 0.0 8e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 CRG89590.1 - 4.1e-06 26.2 0.0 2.8e-05 23.5 0.0 2.0 1 1 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 CRG89590.1 - 0.027 13.4 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Dehydrogenase E1 component Beta_elim_lyase PF01212.21 CRG89590.1 - 0.037 13.3 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Alba PF01918.21 CRG89590.1 - 0.056 13.3 0.4 0.33 10.8 0.0 2.3 3 0 0 3 3 3 0 Alba NmrA PF05368.13 CRG89591.1 - 8.5e-29 100.8 0.0 1.1e-28 100.4 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG89591.1 - 2.4e-13 50.4 0.0 8.1e-13 48.7 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 CRG89591.1 - 4e-06 26.5 0.0 1.2e-05 24.9 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 CRG89591.1 - 0.00049 20.0 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CRG89591.1 - 0.0037 16.7 0.0 0.0055 16.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG89591.1 - 0.0042 16.3 0.0 0.034 13.3 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein Semialdhyde_dh PF01118.24 CRG89591.1 - 0.017 15.6 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 CRG89591.1 - 0.12 11.3 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CRG89591.1 - 0.15 11.2 0.0 1.4 8.0 0.0 2.4 3 0 0 3 3 3 0 Polysaccharide biosynthesis protein Spermine_synth PF01564.17 CRG89592.1 - 7.8e-74 247.2 0.0 1.1e-73 246.7 0.0 1.1 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 CRG89592.1 - 3.1e-23 81.4 0.1 5.2e-23 80.7 0.1 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 CRG89592.1 - 0.00014 22.5 0.0 0.0003 21.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF43 PF01861.16 CRG89592.1 - 0.0063 15.8 0.0 0.0092 15.2 0.0 1.2 1 0 0 1 1 1 1 Branched-chain polyamine synthase A C-terminal domain Methyltransf_12 PF08242.12 CRG89592.1 - 0.0082 16.9 0.2 0.025 15.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 CRG89592.1 - 0.033 14.1 0.0 0.06 13.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 CRG89592.1 - 0.13 11.5 0.2 0.65 9.2 0.1 1.8 1 1 1 2 2 2 0 O-methyltransferase domain UcrQ PF02939.16 CRG89593.1 - 9.1e-24 83.2 1.3 1.4e-23 82.6 1.3 1.2 1 0 0 1 1 1 1 UcrQ family Protamine_like PF06382.11 CRG89593.1 - 0.15 12.2 0.1 0.19 11.9 0.1 1.1 1 0 0 1 1 1 0 Protamine and protamine like Band_7 PF01145.25 CRG89594.1 - 1.1e-24 87.4 7.6 2.1e-24 86.5 6.9 1.7 1 1 1 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 CRG89594.1 - 0.0022 17.1 3.7 0.0029 16.7 3.7 1.2 1 0 0 1 1 1 1 SigmaW regulon antibacterial PknG_rubred PF16919.5 CRG89594.1 - 0.14 12.3 0.2 0.24 11.5 0.2 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain Methyltransf_34 PF11312.8 CRG89595.1 - 1.4e-101 339.8 0.0 1.9e-101 339.4 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase CobT PF06213.12 CRG89595.1 - 0.056 12.8 2.3 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Noc2 PF03715.13 CRG89595.1 - 0.076 12.2 0.0 0.17 11.1 0.0 1.5 1 0 0 1 1 1 0 Noc2p family AMP-binding PF00501.28 CRG89598.1 - 2.8e-276 915.7 0.0 1.6e-73 247.8 0.0 4.2 4 0 0 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 CRG89598.1 - 8.9e-165 548.8 0.2 2.3e-46 158.4 0.0 5.2 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 CRG89598.1 - 3e-49 165.2 0.3 1e-13 51.4 0.0 5.2 4 0 0 4 4 4 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG89598.1 - 5.6e-07 30.4 0.0 2.9 8.9 0.0 4.7 4 0 0 4 4 4 2 AMP-binding enzyme C-terminal domain DUF3328 PF11807.8 CRG89599.1 - 1.4e-43 149.2 0.0 2.2e-43 148.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) P5CR_dimer PF14748.6 CRG89599.1 - 1.2e-18 67.2 3.7 2e-18 66.5 3.7 1.3 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 CRG89599.1 - 6e-05 23.6 0.0 0.00018 22.0 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2OG-FeII_Oxy_3 PF13640.6 CRG89600.1 - 6.9e-07 30.1 0.0 1.2e-06 29.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 CRG89600.1 - 0.002 18.5 0.0 0.0036 17.7 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase ABC_tran PF00005.27 CRG89601.1 - 1.1e-45 155.5 0.0 5e-22 78.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG89601.1 - 4.6e-34 118.3 30.3 1.6e-25 90.3 15.9 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 CRG89601.1 - 6.2e-11 42.6 1.9 0.0026 17.6 0.2 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG89601.1 - 7.3e-11 41.9 5.9 0.0002 20.9 0.1 4.2 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG89601.1 - 5.1e-07 29.3 1.3 0.0027 17.4 0.3 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_24 PF13479.6 CRG89601.1 - 1.6e-05 24.8 0.0 0.019 14.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CRG89601.1 - 1.7e-05 24.8 0.7 0.0067 16.3 0.2 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 CRG89601.1 - 2.9e-05 24.4 0.2 0.27 11.5 0.1 2.9 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG89601.1 - 3e-05 24.5 0.2 0.32 11.4 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 CRG89601.1 - 0.00034 21.2 1.4 0.23 11.9 0.2 2.4 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 CRG89601.1 - 0.0012 17.9 0.1 0.32 10.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA PF00004.29 CRG89601.1 - 0.0013 19.1 0.0 0.73 10.3 0.0 3.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CRG89601.1 - 0.0015 18.1 0.0 0.49 9.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CRG89601.1 - 0.0021 18.1 0.6 1.2 9.3 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 CRG89601.1 - 0.0062 16.3 0.5 0.46 10.1 0.7 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 CRG89601.1 - 0.01 15.4 0.2 3 7.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_33 PF13671.6 CRG89601.1 - 0.011 15.9 0.6 0.32 11.1 0.1 3.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 CRG89601.1 - 0.032 14.0 0.1 0.33 10.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG89601.1 - 0.036 14.4 0.2 4.8 7.6 0.0 2.9 3 0 0 3 3 2 0 RNA helicase Roc PF08477.13 CRG89601.1 - 0.037 14.2 0.3 5.5 7.2 0.0 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 CRG89601.1 - 0.065 13.2 1.7 9.4 6.2 0.1 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CRG89601.1 - 0.068 12.9 0.9 66 3.2 0.0 3.5 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF87 PF01935.17 CRG89601.1 - 0.076 13.1 1.5 0.42 10.7 0.1 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain NACHT PF05729.12 CRG89601.1 - 0.085 12.8 0.4 1.4 8.8 0.1 2.6 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.18 CRG89601.1 - 0.1 11.9 0.6 7.8 5.8 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF815 PF05673.13 CRG89601.1 - 0.13 11.4 0.2 13 4.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Guanylate_kin PF00625.21 CRG89601.1 - 0.15 11.7 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Guanylate kinase SbcCD_C PF13558.6 CRG89601.1 - 0.18 12.1 4.2 8.3 6.7 0.0 3.2 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit cobW PF02492.19 CRG89601.1 - 0.2 11.2 0.7 3 7.4 0.1 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 CRG89601.1 - 1.5 9.4 2.7 24 5.5 0.4 2.4 2 0 0 2 2 2 0 AAA domain DUF3328 PF11807.8 CRG89602.1 - 8.9e-29 100.8 0.2 1.2e-28 100.4 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CRG89603.1 - 2.1e-48 165.0 0.2 2.5e-48 164.7 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CRG89604.1 - 1.2e-17 64.4 0.1 6.9e-17 62.0 0.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) ABC_tran PF00005.27 CRG89605.1 - 7.1e-48 162.6 0.0 1.9e-28 99.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG89605.1 - 1e-34 120.4 30.9 1.1e-22 81.0 6.9 3.1 4 0 0 4 4 4 2 ABC transporter transmembrane region RsgA_GTPase PF03193.16 CRG89605.1 - 3.7e-06 27.0 0.1 0.0044 16.9 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase SMC_N PF02463.19 CRG89605.1 - 1.3e-05 24.8 2.3 0.26 10.7 0.0 3.8 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG89605.1 - 7.6e-05 22.4 0.1 0.033 13.9 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CRG89605.1 - 0.00021 21.7 0.3 0.51 10.7 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 CRG89605.1 - 0.00034 20.9 0.6 1.4 9.2 0.1 3.2 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 CRG89605.1 - 0.00054 20.0 3.3 0.23 11.6 0.0 3.0 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_21 PF13304.6 CRG89605.1 - 0.0011 18.9 2.5 0.96 9.2 0.1 4.1 5 0 0 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CRG89605.1 - 0.0017 18.9 3.5 0.052 14.0 0.1 2.9 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 CRG89605.1 - 0.0019 17.8 0.1 0.36 10.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 CRG89605.1 - 0.0068 16.8 0.0 1.6 9.1 0.0 3.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 CRG89605.1 - 0.01 15.6 0.5 9.7 5.9 0.1 3.3 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 CRG89605.1 - 0.027 14.6 2.2 0.47 10.5 0.0 2.8 2 0 0 2 2 2 0 Helicase HerA, central domain DUF1199 PF06712.11 CRG89605.1 - 0.03 14.3 1.0 0.083 12.9 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1199) IstB_IS21 PF01695.17 CRG89605.1 - 0.035 13.8 0.5 3.8 7.2 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein ATP-synt_ab PF00006.25 CRG89605.1 - 0.1 12.2 0.0 7.1 6.2 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain MeaB PF03308.16 CRG89605.1 - 0.18 10.8 0.4 0.71 8.8 0.1 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DIOX_N PF14226.6 CRG89606.1 - 1.4e-24 87.2 0.0 2.1e-24 86.5 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG89606.1 - 1.9e-11 44.3 0.0 3.4e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UbiA PF01040.18 CRG89607.1 - 2.5e-39 135.1 16.3 3.1e-39 134.8 15.8 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family NACHT PF05729.12 CRG89608.1 - 7.3e-09 35.8 0.3 1.2e-07 31.8 0.3 2.5 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG89608.1 - 6.8e-07 29.8 0.1 6.8e-07 29.8 0.1 2.6 3 0 0 3 3 3 1 AAA ATPase domain ATPase_2 PF01637.18 CRG89608.1 - 0.0069 16.3 0.0 0.017 15.0 0.0 1.7 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 CRG89608.1 - 0.011 15.0 0.0 0.053 12.7 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain Ank PF00023.30 CRG89608.1 - 0.011 16.1 0.0 0.23 12.0 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat AAA_22 PF13401.6 CRG89608.1 - 0.012 15.9 0.1 0.045 14.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain L27_N PF09060.10 CRG89608.1 - 0.056 13.5 0.3 0.34 11.0 0.4 2.3 2 0 0 2 2 2 0 L27_N RsgA_GTPase PF03193.16 CRG89608.1 - 0.099 12.5 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CRG89608.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 CRG89608.1 - 0.17 12.4 0.0 0.6 10.6 0.0 1.9 1 0 0 1 1 1 0 ABC transporter DUF802 PF05650.11 CRG89608.1 - 0.24 11.9 2.2 0.9 10.0 2.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF802) AAA_23 PF13476.6 CRG89608.1 - 2.6 8.5 4.6 4.6 7.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain DUF3328 PF11807.8 CRG89609.1 - 3.1e-45 154.6 0.2 4.2e-45 154.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CRG89610.1 - 1.4e-33 116.6 2.1 1.9e-33 116.1 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Aldo_ket_red PF00248.21 CRG89611.1 - 1.2e-53 182.3 0.0 1.3e-53 182.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family VirionAssem_T7 PF11653.8 CRG89612.1 - 0.022 15.2 0.1 0.049 14.1 0.1 1.5 1 0 0 1 1 1 0 Bacteriophage T7 virion assembly protein Tubulin PF00091.25 CRG89613.1 - 1e-69 234.7 0.0 1.6e-69 234.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CRG89613.1 - 7.4e-45 152.2 1.0 1.2e-44 151.5 0.2 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 CRG89613.1 - 9e-08 32.4 0.0 2e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 CRG89613.1 - 0.035 13.3 0.0 0.056 12.6 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Tubulin_3 PF14881.6 CRG89613.1 - 0.065 12.9 0.1 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 Tubulin domain DUF202 PF02656.15 CRG89614.1 - 2.7e-22 79.0 0.4 2.7e-22 79.0 0.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF202) PTPA PF03095.15 CRG89615.1 - 1.2e-108 363.1 0.0 1.4e-108 362.9 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein LRR_10 PF18805.1 CRG89615.1 - 0.16 11.6 0.1 0.33 10.6 0.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeat zf-AN1 PF01428.16 CRG89616.1 - 2.2e-12 46.9 7.5 2.2e-12 46.9 7.5 1.6 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 CRG89616.1 - 0.11 12.9 8.1 0.057 13.8 6.1 1.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain ArabFuran-catal PF09206.11 CRG89617.1 - 1.8e-146 487.4 12.6 2e-146 487.3 12.6 1.0 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic DUF1754 PF08555.10 CRG89618.1 - 2.2e-05 25.1 25.6 4.2e-05 24.3 25.7 1.5 1 1 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) CDC27 PF09507.10 CRG89618.1 - 0.0053 16.2 13.9 0.0058 16.1 13.9 1.0 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Adaptin_binding PF10199.9 CRG89618.1 - 0.18 12.4 11.5 0.25 12.0 11.5 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 PA26 PF04636.13 CRG89618.1 - 0.66 8.8 2.6 0.76 8.6 2.6 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) FAM60A PF15396.6 CRG89618.1 - 0.96 9.4 7.4 1.1 9.2 7.4 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 CRG89618.1 - 1.1 8.2 3.5 1.2 8.1 3.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Phlebovirus_NSM PF07246.11 CRG89618.1 - 1.2 8.4 12.2 1.6 8.1 12.2 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF3818 PF12825.7 CRG89618.1 - 2.9 6.8 6.1 3.6 6.5 6.1 1.0 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) EamA PF00892.20 CRG89619.1 - 8.6e-13 48.6 25.2 1.7e-06 28.3 0.4 2.4 2 0 0 2 2 2 2 EamA-like transporter family CSG2 PF16965.5 CRG89619.1 - 5.4e-06 25.6 16.4 0.00011 21.3 15.5 2.6 1 1 0 1 1 1 1 Ceramide synthase regulator Nuc_sug_transp PF04142.15 CRG89619.1 - 0.0022 17.3 8.4 0.0053 16.0 8.4 1.5 1 1 0 1 1 1 1 Nucleotide-sugar transporter Actin PF00022.19 CRG89620.1 - 7.2e-111 370.7 0.0 4.8e-110 368.0 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 CRG89620.1 - 0.045 12.6 0.0 0.38 9.5 0.0 2.2 1 1 0 1 1 1 0 MreB/Mbl protein NAD_binding_2 PF03446.15 CRG89621.1 - 9.4e-23 81.1 0.1 1.4e-22 80.5 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG89621.1 - 3.9e-12 46.5 0.0 7.5e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF3425 PF11905.8 CRG89622.1 - 4.2e-20 72.0 3.4 7.8e-20 71.1 3.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CRG89622.1 - 0.034 14.2 10.0 0.12 12.5 10.0 1.9 1 1 0 1 1 1 0 bZIP transcription factor COG5 PF10392.9 CRG89622.1 - 0.075 13.2 0.3 0.59 10.3 1.0 2.0 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF5349 PF17298.2 CRG89622.1 - 8.8 6.0 11.0 0.07 12.9 2.8 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5349) GTP_cyclohydro2 PF00925.20 CRG89624.1 - 9.9e-58 194.3 0.0 1.6e-57 193.6 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF1325 PF07039.11 CRG89625.1 - 1e-33 116.2 0.0 2.4e-33 115.0 0.0 1.6 1 0 0 1 1 1 1 SGF29 tudor-like domain LBR_tudor PF09465.10 CRG89625.1 - 0.024 14.4 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain DUF2540 PF10802.8 CRG89625.1 - 0.052 13.6 0.8 0.25 11.4 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2540) PilZ PF07238.14 CRG89625.1 - 0.073 13.4 0.1 17 5.8 0.0 2.4 1 1 1 2 2 2 0 PilZ domain PMI_typeI PF01238.21 CRG89626.1 - 2.8e-147 490.8 0.0 3.3e-147 490.6 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 CRG89626.1 - 0.05 13.5 0.0 14 5.6 0.0 2.7 2 0 0 2 2 2 0 AraC-like ligand binding domain PI-PLC-X PF00388.19 CRG89627.1 - 6.5e-60 200.9 0.0 1.3e-59 199.9 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 CRG89627.1 - 1.2e-41 141.6 0.1 1.2e-40 138.4 0.1 2.5 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 CRG89627.1 - 0.00021 21.5 0.0 0.00097 19.4 0.0 2.0 1 1 0 1 1 1 1 C2 domain EF-hand_7 PF13499.6 CRG89627.1 - 0.00073 19.9 0.8 0.0076 16.7 0.7 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_like PF09279.11 CRG89627.1 - 0.0013 19.2 0.3 0.0033 17.9 0.1 1.7 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_1 PF00036.32 CRG89627.1 - 0.0014 18.0 0.0 0.018 14.6 0.0 2.8 3 0 0 3 3 3 1 EF hand GDPD PF03009.17 CRG89627.1 - 0.049 13.4 0.0 0.099 12.3 0.0 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Glyco_hydro_16 PF00722.21 CRG89628.1 - 3.2e-40 137.5 6.0 3.2e-40 137.5 6.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Aldo_ket_red PF00248.21 CRG89629.1 - 6.2e-64 216.0 0.0 7.2e-64 215.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AUDH_Cupin PF18637.1 CRG89630.1 - 8.8e-64 214.3 2.3 1.5e-63 213.5 2.3 1.4 1 0 0 1 1 1 1 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain PBP3 PF18056.1 CRG89630.1 - 1.4e-33 115.3 0.0 2.3e-33 114.6 0.0 1.4 1 0 0 1 1 1 1 Penicillin Binding Protein 3 Domain VCBS PF13517.6 CRG89630.1 - 7.1e-06 26.5 0.5 0.058 14.0 0.0 4.6 4 0 0 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 CRG89630.1 - 0.024 14.8 6.0 2.6 8.3 1.6 2.8 2 0 0 2 2 2 0 FG-GAP repeat GMC_oxred_C PF05199.13 CRG89631.1 - 3.8e-11 43.7 0.1 7.4e-10 39.5 0.0 2.8 2 1 0 2 2 2 1 GMC oxidoreductase GMC_oxred_N PF00732.19 CRG89631.1 - 0.0028 17.1 0.0 0.0053 16.2 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase BNR_2 PF13088.6 CRG89632.1 - 1.7e-73 247.3 0.1 2.1e-73 247.1 0.1 1.1 1 0 0 1 1 1 1 BNR repeat-like domain BNR_4 PF15892.5 CRG89632.1 - 6.2e-06 25.8 0.0 0.44 9.9 0.0 3.4 2 1 1 3 3 3 2 BNR repeat-containing family member BNR PF02012.20 CRG89632.1 - 5.8e-05 22.5 14.2 0.078 13.0 0.4 5.0 4 0 0 4 4 4 3 BNR/Asp-box repeat Sugar_tr PF00083.24 CRG89633.1 - 4.8e-100 335.5 19.3 5.8e-100 335.3 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG89633.1 - 1.9e-25 89.5 20.5 1.9e-25 89.5 20.5 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Patatin PF01734.22 CRG89633.1 - 0.41 10.8 0.0 0.41 10.8 0.0 2.1 2 1 0 2 2 2 0 Patatin-like phospholipase Coatomer_E PF04733.14 CRG89634.1 - 1e-62 212.2 4.3 1.2e-62 212.0 4.3 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 CRG89634.1 - 1e-09 38.8 14.2 0.00017 22.0 0.4 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG89634.1 - 2.7e-08 33.9 0.2 0.0016 18.6 0.1 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 CRG89634.1 - 4.5e-08 33.6 5.8 0.01 16.5 0.1 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 CRG89634.1 - 1.4e-06 28.4 5.7 0.68 10.7 0.6 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CRG89634.1 - 1.4e-05 25.4 0.4 1.4 9.7 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 CRG89634.1 - 0.00019 21.9 10.5 0.0066 17.2 0.3 4.7 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG89634.1 - 0.00039 20.1 0.2 0.25 11.2 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89634.1 - 0.0017 18.6 4.8 1.6 9.0 0.2 3.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89634.1 - 0.016 15.2 9.8 0.028 14.5 0.1 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 CRG89634.1 - 0.028 13.6 3.7 0.28 10.4 0.3 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat Type_III_YscG PF09477.10 CRG89634.1 - 0.029 14.5 0.9 1.5 8.9 0.2 3.2 2 1 2 4 4 4 0 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_21 PF09976.9 CRG89634.1 - 0.18 11.5 8.6 9.2 5.9 5.0 2.6 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 CRG89634.1 - 0.37 11.1 6.2 0.72 10.2 2.8 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat UPF1_Zn_bind PF09416.10 CRG89636.1 - 1.1e-72 243.0 3.1 1.5e-72 242.5 1.8 1.9 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 CRG89636.1 - 1.1e-59 201.4 0.0 2.5e-59 200.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CRG89636.1 - 3.4e-54 184.4 2.9 6.7e-31 108.0 0.2 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 CRG89636.1 - 2.8e-33 114.0 0.0 5.3e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 CRG89636.1 - 1.3e-13 51.1 0.3 2.1e-12 47.2 0.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 CRG89636.1 - 3.7e-11 43.5 0.0 2.5e-10 40.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain ResIII PF04851.15 CRG89636.1 - 4.6e-06 26.8 0.0 8.4e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 CRG89636.1 - 4.9e-05 23.2 0.2 0.48 10.1 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 CRG89636.1 - 0.00036 19.9 0.0 0.012 14.9 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CRG89636.1 - 0.00057 19.8 0.0 0.0012 18.8 0.0 1.6 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 CRG89636.1 - 0.0019 17.8 0.0 0.022 14.3 0.0 2.2 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 CRG89636.1 - 0.0025 17.1 0.1 0.57 9.3 0.0 2.2 2 0 0 2 2 2 2 PIF1-like helicase DEAD PF00270.29 CRG89636.1 - 0.0079 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_10 PF12846.7 CRG89636.1 - 0.014 14.3 0.0 0.023 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain ATPase PF06745.13 CRG89636.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_22 PF13401.6 CRG89636.1 - 0.14 12.4 0.0 0.38 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 CRG89636.1 - 0.17 12.3 0.0 0.53 10.7 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Brix PF04427.18 CRG89637.1 - 2.8e-31 109.2 0.0 3.5e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Brix domain PTCB-BRCT PF12738.7 CRG89638.1 - 6.6e-09 35.6 0.1 1.3e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 CRG89638.1 - 7.8e-08 32.6 0.0 1.9e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 CRG89638.1 - 0.00025 21.4 0.0 0.00064 20.1 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CRG89638.1 - 0.00085 19.6 0.4 0.0025 18.0 0.1 1.9 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain IGPS PF00218.21 CRG89639.1 - 2.4e-94 315.2 0.0 5.5e-94 314.1 0.0 1.6 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 CRG89639.1 - 3e-53 180.5 0.0 2e-49 168.0 0.0 2.3 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 CRG89639.1 - 5.1e-46 156.8 0.0 8.9e-46 156.1 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 CRG89639.1 - 1e-05 25.4 0.2 3.8e-05 23.5 0.2 1.9 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 CRG89639.1 - 0.0032 17.3 0.5 0.079 12.7 0.0 2.7 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain Peripla_BP_2 PF01497.18 CRG89639.1 - 0.017 14.7 0.1 0.053 13.1 0.0 1.8 2 0 0 2 2 2 0 Periplasmic binding protein NanE PF04131.14 CRG89639.1 - 0.019 14.2 1.4 0.52 9.5 0.0 3.2 3 0 0 3 3 3 0 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 CRG89639.1 - 0.024 14.1 0.1 0.12 11.9 0.0 2.2 2 0 0 2 2 2 0 Histidine biosynthesis protein Nup188_C PF18378.1 CRG89640.1 - 2e-144 481.0 0.4 3e-144 480.4 0.4 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 CRG89640.1 - 3.6e-78 263.5 0.0 3.2e-77 260.4 0.0 2.2 1 1 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 CK2S PF15011.6 CRG89640.1 - 0.14 12.0 0.8 0.58 10.0 0.8 2.1 1 0 0 1 1 1 0 Casein Kinase 2 substrate G-alpha PF00503.20 CRG89641.1 - 9.5e-124 413.1 1.4 1.1e-123 412.9 1.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CRG89641.1 - 1.8e-15 56.8 1.1 2.9e-10 39.9 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 CRG89641.1 - 5.8e-05 22.8 0.0 0.00026 20.8 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger AAA_29 PF13555.6 CRG89641.1 - 0.0035 17.1 0.1 0.026 14.2 0.1 2.2 1 1 1 2 2 2 1 P-loop containing region of AAA domain Gtr1_RagA PF04670.12 CRG89641.1 - 0.0039 16.6 3.3 0.081 12.3 0.1 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CRG89641.1 - 0.017 15.3 0.8 2.4 8.4 0.0 2.9 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 CRG89641.1 - 0.063 12.4 0.0 0.11 11.5 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain FtsK_SpoIIIE PF01580.18 CRG89641.1 - 0.08 12.3 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 CRG89641.1 - 0.12 12.5 0.1 8.8 6.5 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG89641.1 - 0.13 11.8 0.0 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Use1 PF09753.9 CRG89642.1 - 1.4e-10 41.3 12.2 1.9e-09 37.6 11.9 2.0 1 1 0 1 1 1 1 Membrane fusion protein Use1 PTPRCAP PF15713.5 CRG89642.1 - 0.048 14.0 15.0 0.1 12.9 15.0 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 CRG89642.1 - 0.26 9.5 10.2 0.29 9.4 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 CRG89642.1 - 1.3 7.5 15.4 1.8 7.1 15.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) YlbD_coat PF14071.6 CRG89642.1 - 2.8 8.2 8.0 62 3.9 5.5 2.6 2 1 1 3 3 3 0 Putative coat protein Pes-10 PF07149.11 CRG89642.1 - 6.9 5.6 10.6 10 5.0 10.6 1.2 1 0 0 1 1 1 0 Pes-10 DUF1771 PF08590.10 CRG89644.1 - 2.7e-25 88.5 8.4 8.3e-25 87.0 8.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 CRG89644.1 - 3.2e-11 43.4 1.8 1.5e-10 41.3 0.5 2.6 3 0 0 3 3 3 1 Smr domain Phasin PF05597.11 CRG89644.1 - 0.097 12.7 1.6 9 6.3 0.0 2.6 3 1 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4407 PF14362.6 CRG89644.1 - 0.88 8.9 2.6 1.3 8.3 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Connexin43 PF03508.13 CRG89644.1 - 3.1 7.4 5.7 0.44 10.1 0.8 2.0 2 0 0 2 2 2 0 Gap junction alpha-1 protein (Cx43) Cwf_Cwc_15 PF04889.12 CRG89645.1 - 0.0065 16.2 4.7 0.0069 16.2 4.7 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Drc1-Sld2 PF11719.8 CRG89645.1 - 0.0092 15.6 2.0 0.01 15.4 2.0 1.0 1 0 0 1 1 1 1 DNA replication and checkpoint protein DUF733 PF05306.11 CRG89645.1 - 0.015 15.6 0.8 0.022 15.1 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF733) RF-1 PF00472.20 CRG89645.1 - 0.026 14.5 0.5 0.038 13.9 0.5 1.3 1 0 0 1 1 1 0 RF-1 domain DNA_pol_phi PF04931.13 CRG89645.1 - 0.035 12.2 6.3 0.039 12.1 6.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi CSRNP_N PF16019.5 CRG89645.1 - 0.051 13.5 1.7 0.062 13.2 1.7 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus FAM176 PF14851.6 CRG89645.1 - 0.069 12.8 1.8 0.11 12.1 1.8 1.5 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 CRG89645.1 - 0.12 12.6 4.7 0.2 11.9 4.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 CRG89645.1 - 0.95 8.7 6.2 1.3 8.3 6.2 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 CRG89645.1 - 0.96 9.9 13.8 0.5 10.8 11.8 1.5 1 1 0 1 1 1 0 Centromere protein B dimerisation domain DUF688 PF05097.12 CRG89645.1 - 2.7 7.0 8.9 1.8 7.7 7.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF688) WRNPLPNID PF15017.6 CRG89645.1 - 5.2 8.0 10.5 13 6.7 10.5 1.6 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box polyprenyl_synt PF00348.17 CRG89646.1 - 5.3e-67 225.6 0.0 6.6e-67 225.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase DUF5521 PF17659.1 CRG89646.1 - 0.041 11.7 0.3 0.059 11.2 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5521) CDC14 PF08045.11 CRG89647.1 - 1.4e-130 434.5 0.0 1.6e-130 434.4 0.0 1.0 1 0 0 1 1 1 1 Cell division control protein 14, SIN component SKG6 PF08693.10 CRG89648.1 - 4e-06 26.1 2.2 8.9e-06 25.0 2.2 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Podoplanin PF05808.11 CRG89648.1 - 0.0011 19.1 3.7 0.002 18.3 3.7 1.4 1 0 0 1 1 1 1 Podoplanin Rax2 PF12768.7 CRG89648.1 - 0.0032 16.9 0.0 0.0049 16.4 0.0 1.2 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Mid2 PF04478.12 CRG89648.1 - 0.018 14.9 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Gram_pos_anchor PF00746.21 CRG89648.1 - 0.64 10.0 2.1 1.5 8.9 2.1 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Hamartin PF04388.12 CRG89648.1 - 3.5 6.2 11.2 4.2 5.9 8.9 1.8 2 0 0 2 2 2 0 Hamartin protein Rhodanese PF00581.20 CRG89649.1 - 6.6e-31 107.0 0.0 2.6e-08 34.4 0.0 4.4 4 0 0 4 4 4 4 Rhodanese-like domain TPR_1 PF00515.28 CRG89651.1 - 6.6e-07 28.9 6.5 1.4e-05 24.7 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG89651.1 - 9.4e-06 25.3 7.0 0.0035 17.3 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89651.1 - 0.00017 21.5 0.0 0.00017 21.5 0.0 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG89651.1 - 0.00041 20.9 7.1 12 7.1 0.1 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 CRG89651.1 - 0.0057 16.3 9.4 0.021 14.5 0.0 4.3 5 0 0 5 5 5 2 TPR repeat TPR_8 PF13181.6 CRG89651.1 - 0.016 15.4 0.8 0.68 10.3 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89651.1 - 0.26 11.6 15.4 3.8 7.9 1.7 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat MFS_1 PF07690.16 CRG89652.1 - 8.1e-29 100.6 25.2 1.8e-28 99.5 23.2 1.9 2 0 0 2 2 2 2 Major Facilitator Superfamily DIOX_N PF14226.6 CRG89653.1 - 1.9e-20 73.7 0.0 8.2e-20 71.7 0.0 1.9 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG89653.1 - 2.4e-14 53.7 0.0 3.8e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GDE_C PF06202.14 CRG89655.1 - 0.085 11.8 0.0 2.8 6.8 0.0 2.4 2 1 1 3 3 3 0 Amylo-alpha-1,6-glucosidase CorA PF01544.18 CRG89655.1 - 0.21 10.9 2.6 0.62 9.3 2.6 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein End3 PF12761.7 CRG89656.1 - 3.2e-71 239.6 1.0 4.4e-71 239.2 1.0 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 CRG89656.1 - 6.1e-53 177.2 0.0 2.6e-49 165.5 0.1 2.3 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 CRG89656.1 - 6.6e-08 31.6 0.6 1.8e-07 30.2 0.3 2.0 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 CRG89656.1 - 7.7e-07 29.5 0.8 5.3e-06 26.8 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 CRG89656.1 - 0.00012 21.7 0.4 0.00041 20.1 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 CRG89656.1 - 0.00016 21.5 0.1 0.0049 16.7 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 CRG89656.1 - 0.0029 17.0 0.2 0.0095 15.4 0.2 1.9 1 0 0 1 1 1 1 EF hand RPW8 PF05659.11 CRG89656.1 - 0.14 11.8 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TolA_bind_tri PF16331.5 CRG89656.1 - 0.3 11.2 4.6 5.7 7.1 0.4 3.0 2 1 0 2 2 2 0 TolA binding protein trimerisation DUF4407 PF14362.6 CRG89656.1 - 0.63 9.3 4.7 1.2 8.4 4.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 CRG89656.1 - 2.1 8.4 6.5 1 9.5 1.3 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 CRG89656.1 - 2.3 7.9 9.2 0.37 10.5 4.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) Spc7 PF08317.11 CRG89656.1 - 4.8 6.0 8.1 2 7.2 4.1 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein SNF2_N PF00176.23 CRG89657.1 - 9.3e-64 215.3 0.1 3.2e-63 213.6 0.0 1.7 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG89657.1 - 2.3e-22 79.4 0.7 2.7e-21 76.0 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG89657.1 - 5.3e-08 33.0 0.0 2e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 CRG89657.1 - 6.3e-05 22.3 0.0 6.3e-05 22.3 0.0 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase HDA2-3 PF11496.8 CRG89657.1 - 9.8e-05 21.6 0.0 0.0022 17.2 0.0 2.6 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DUF1676 PF07898.13 CRG89657.1 - 5.8 6.9 6.8 3 7.9 3.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) TEX13 PF15186.6 CRG89658.1 - 0.031 13.9 0.1 0.073 12.8 0.1 1.5 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family DSPc PF00782.20 CRG89659.1 - 5.3e-14 52.2 0.0 9.5e-14 51.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 CRG89659.1 - 0.0027 18.0 0.0 0.0043 17.3 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain B3_4 PF03483.17 CRG89660.1 - 9.1e-21 74.3 0.0 1.2e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 B3/4 domain NACHT PF05729.12 CRG89660.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain FMN_bind_2 PF04299.12 CRG89661.1 - 3.6e-59 199.2 0.3 4.3e-59 199.0 0.3 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain But2 PF09792.9 CRG89662.1 - 0.0012 19.2 0.0 0.0019 18.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain Raf1_N PF18578.1 CRG89663.1 - 0.18 12.3 0.0 0.28 11.7 0.0 1.2 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain hNIFK_binding PF12196.8 CRG89664.1 - 0.16 11.5 37.3 1.3 8.6 0.7 6.0 5 1 1 6 6 6 0 FHA Ki67 binding domain of hNIFK CbiN PF02553.15 CRG89664.1 - 0.57 10.2 5.8 43 4.2 0.1 3.9 1 1 3 4 4 4 0 Cobalt transport protein component CbiN DUF3328 PF11807.8 CRG89665.1 - 1.3e-24 87.2 2.4 6.4e-23 81.7 2.4 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) Tyrosinase PF00264.20 CRG89666.1 - 2e-36 126.4 10.8 5.6e-36 124.9 10.8 1.7 1 1 0 1 1 1 1 Common central domain of tyrosinase N2227 PF07942.12 CRG89667.1 - 2.3e-57 194.3 0.0 3e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 CRG89667.1 - 1.9e-09 38.0 0.0 1.2e-07 32.3 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89667.1 - 1.2e-06 29.2 0.1 0.0004 21.0 0.0 2.7 2 1 0 3 3 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG89667.1 - 1.9e-06 27.8 0.0 3.5e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89667.1 - 3.4e-06 27.7 0.0 2e-05 25.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89667.1 - 0.00053 19.8 0.0 0.041 13.7 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_8 PF05148.15 CRG89667.1 - 0.013 15.4 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_24 PF13578.6 CRG89667.1 - 0.015 16.3 0.0 0.044 14.8 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 CRG89667.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Nif11 PF07862.11 CRG89667.1 - 0.12 12.7 0.1 14 6.1 0.0 3.3 3 0 0 3 3 3 0 Nif11 domain DUF938 PF06080.12 CRG89667.1 - 0.13 12.0 0.0 1.6 8.4 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 CRG89667.1 - 0.21 10.9 0.0 0.39 10.0 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family A_deaminase PF00962.22 CRG89668.1 - 4.8e-23 82.0 0.0 6e-23 81.7 0.0 1.0 1 0 0 1 1 1 1 Adenosine/AMP deaminase zf-C2H2_aberr PF17017.5 CRG89669.1 - 8.6e-06 26.0 1.0 9.5e-06 25.9 0.1 1.5 2 0 0 2 2 2 1 Aberrant zinc-finger zf-C2H2 PF00096.26 CRG89669.1 - 2.3e-05 24.6 17.1 0.28 11.7 0.1 3.9 3 1 0 3 3 3 3 Zinc finger, C2H2 type Cnn_1N PF07989.11 CRG89669.1 - 0.02 15.0 0.3 0.063 13.4 0.2 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 zf-C2H2_4 PF13894.6 CRG89669.1 - 0.045 14.6 8.7 13 6.9 0.7 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger Transpos_assoc PF13963.6 CRG89669.1 - 0.066 13.5 3.3 0.16 12.3 0.2 2.3 2 0 0 2 2 2 0 Transposase-associated domain OrsD PF12013.8 CRG89669.1 - 0.24 11.9 0.1 0.24 11.9 0.1 2.7 2 1 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf_CCCH_4 PF18345.1 CRG89670.1 - 0.2 11.8 0.2 0.2 11.8 0.2 4.4 4 0 0 4 4 4 0 Zinc finger domain JAKMIP_CC3 PF16034.5 CRG89670.1 - 0.29 11.0 5.4 6.4 6.7 1.1 2.3 2 0 0 2 2 2 0 JAKMIP CC3 domain Syntaxin_2 PF14523.6 CRG89670.1 - 0.74 10.2 3.1 0.32 11.4 0.4 1.7 2 0 0 2 2 2 0 Syntaxin-like protein Amidohydro_2 PF04909.14 CRG89671.1 - 8.3e-14 52.0 0.0 1.4e-13 51.3 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 CRG89671.1 - 0.08 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 TatD related DNase DUF3439 PF11921.8 CRG89672.1 - 0.11 12.5 0.3 0.21 11.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) adh_short PF00106.25 CRG89673.1 - 1.3e-07 31.2 0.3 2e-07 30.7 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89673.1 - 2.1e-06 27.8 0.2 3.6e-06 27.0 0.2 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG89673.1 - 2.9e-05 23.8 0.5 5.5e-05 22.8 0.5 1.4 1 1 1 2 2 2 1 Enoyl-(Acyl carrier protein) reductase PEP_mutase PF13714.6 CRG89673.1 - 0.04 13.4 0.3 0.1 12.0 0.3 1.5 1 1 1 2 2 2 0 Phosphoenolpyruvate phosphomutase Eno-Rase_NADH_b PF12242.8 CRG89673.1 - 0.049 13.4 1.1 0.1 12.3 0.5 1.7 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PNP_UDP_1 PF01048.20 CRG89674.1 - 2.2e-13 50.0 0.0 3.6e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily NB-ARC PF00931.22 CRG89674.1 - 2.4e-08 33.5 0.0 4.6e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 CRG89674.1 - 2.2e-07 31.4 0.1 8.9e-07 29.4 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 CRG89674.1 - 4.5e-06 26.7 0.0 7.9e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 CRG89674.1 - 0.019 14.9 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CRG89674.1 - 0.026 14.8 0.0 0.076 13.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG89674.1 - 0.14 12.2 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DDE_3 PF13358.6 CRG89675.1 - 9.6e-32 109.7 0.0 2.8e-31 108.3 0.0 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 CRG89675.1 - 9.1e-06 25.2 0.2 2.2e-05 24.0 0.2 1.6 1 0 0 1 1 1 1 Winged helix-turn helix rve PF00665.26 CRG89675.1 - 6.9e-05 23.0 0.0 0.00016 21.8 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain HTH_37 PF13744.6 CRG89675.1 - 0.058 13.3 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain DDE_Tnp_ISAZ013 PF07592.11 CRG89675.1 - 0.065 12.2 0.8 1.6 7.7 0.0 2.1 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain Colicin_E5 PF12106.8 CRG89675.1 - 0.17 12.2 0.0 0.35 11.2 0.0 1.4 1 0 0 1 1 1 0 Colicin E5 ribonuclease domain RVT_1 PF00078.27 CRG89676.1 - 3.3e-07 30.0 0.0 7.2e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Xpo1 PF08389.12 CRG89676.1 - 0.11 12.6 0.7 0.74 9.9 0.0 2.7 4 0 0 4 4 4 0 Exportin 1-like protein Phage_int_SAM_4 PF13495.6 CRG89676.1 - 0.15 12.6 1.4 2.1 8.9 0.0 3.4 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain Pox_A_type_inc PF04508.12 CRG89676.1 - 2.6 8.0 7.9 1.9 8.4 0.1 3.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat APH PF01636.23 CRG89677.1 - 1.7e-11 44.5 0.0 2.8e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Transp_cyt_pur PF02133.15 CRG89678.1 - 8.4e-149 496.1 45.0 9.8e-149 495.9 45.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Urb2 PF10441.9 CRG89679.1 - 2.4e-59 200.7 0.2 1.2e-58 198.4 0.2 2.3 1 0 0 1 1 1 1 Urb2/Npa2 family HTH_22 PF13309.6 CRG89679.1 - 0.056 13.5 0.0 0.25 11.4 0.0 2.1 1 0 0 1 1 1 0 HTH domain RPAP1_N PF08621.10 CRG89679.1 - 0.25 11.2 1.8 1.1 9.1 0.2 3.0 2 0 0 2 2 2 0 RPAP1-like, N-terminal DUF543 PF04418.12 CRG89680.1 - 1.8e-28 98.3 0.0 2.1e-28 98.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF543) GST_N_4 PF17172.4 CRG89682.1 - 9.8e-24 84.0 0.1 2e-23 83.0 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 CRG89682.1 - 1e-19 70.1 0.1 1.9e-19 69.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 CRG89682.1 - 5.3e-14 52.6 0.1 1e-13 51.7 0.1 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 CRG89682.1 - 5.2e-07 30.0 0.1 1.4e-06 28.6 0.1 1.7 1 0 0 1 1 1 1 SAM35, subunit of SAM coomplex GST_C_2 PF13410.6 CRG89682.1 - 0.035 14.1 0.1 0.058 13.4 0.1 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Methyltransf_25 PF13649.6 CRG89683.1 - 6.3e-10 39.6 0.0 1.1e-09 38.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89683.1 - 7.8e-10 38.7 0.0 1.1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG89683.1 - 3.7e-09 37.2 0.0 8e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG89683.1 - 1.6e-08 34.6 0.0 2.3e-08 34.0 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89683.1 - 1.7e-07 31.8 0.0 3.4e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG89683.1 - 0.00016 21.1 0.0 0.00025 20.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_33 PF10017.9 CRG89683.1 - 0.0078 15.4 0.0 0.014 14.5 0.0 1.4 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent CheR PF01739.18 CRG89683.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain bMG1 PF17970.1 CRG89683.1 - 0.024 14.7 0.1 0.18 11.9 0.0 2.2 2 0 0 2 2 2 0 Bacterial Alpha-2-macroglobulin MG1 domain Methyltransf_7 PF03492.15 CRG89683.1 - 0.04 13.1 0.0 0.06 12.6 0.0 1.2 1 0 0 1 1 1 0 SAM dependent carboxyl methyltransferase Methyltransf_32 PF13679.6 CRG89683.1 - 0.052 13.5 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 CRG89683.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_28 PF02636.17 CRG89683.1 - 0.14 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 CRG89683.1 - 0.14 11.7 0.2 0.61 9.6 0.2 2.1 1 1 0 1 1 1 0 Methyltransferase small domain Mit_KHE1 PF10173.9 CRG89684.1 - 2.4e-64 216.9 0.4 3.9e-64 216.3 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related MARVEL PF01284.23 CRG89685.1 - 0.065 13.3 0.5 0.11 12.6 0.5 1.3 1 0 0 1 1 1 0 Membrane-associating domain Cupin_2 PF07883.11 CRG89686.1 - 2e-06 27.4 0.0 3.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CRG89686.1 - 3.2e-06 26.8 0.1 4.9e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.14 CRG89686.1 - 0.0048 17.1 0.0 0.0068 16.6 0.0 1.3 1 0 0 1 1 1 1 ARD/ARD' family Cupin_6 PF12852.7 CRG89686.1 - 0.047 13.4 0.0 0.056 13.2 0.0 1.3 1 0 0 1 1 1 0 Cupin Cullin PF00888.22 CRG89687.1 - 5.7e-192 639.6 10.0 7.9e-192 639.1 10.0 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CRG89687.1 - 2.6e-26 91.4 4.4 1.3e-25 89.2 4.4 2.3 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF1906 PF08924.11 CRG89687.1 - 0.11 12.6 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1906) WAC_Acf1_DNA_bd PF10537.9 CRG89687.1 - 0.24 11.9 3.1 0.76 10.3 1.2 2.7 2 0 0 2 2 2 0 ATP-utilising chromatin assembly and remodelling N-terminal AnfG_VnfG PF03139.15 CRG89687.1 - 3.2 7.9 10.4 0.12 12.5 1.5 3.1 3 1 1 4 4 4 0 Vanadium/alternative nitrogenase delta subunit Phosphorylase PF00343.20 CRG89689.1 - 0 1046.9 0.0 0 1046.7 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase HA70_C PF17993.1 CRG89689.1 - 0.014 15.4 0.1 0.59 10.2 0.0 2.7 2 0 0 2 2 2 0 Haemagglutinin 70 C-terminal domain G-alpha PF00503.20 CRG89690.1 - 4.1e-115 384.7 0.3 4.7e-115 384.5 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CRG89690.1 - 3.5e-15 55.9 0.9 2.6e-10 40.0 0.3 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 CRG89690.1 - 1.5e-05 24.5 0.1 0.063 12.6 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 CRG89690.1 - 0.0026 18.0 0.2 0.69 10.2 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 CRG89690.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pkinase PF00069.25 CRG89691.1 - 3.8e-66 223.2 0.0 4.7e-66 222.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89691.1 - 2.7e-31 108.8 0.0 3.8e-31 108.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG89691.1 - 1.3e-05 24.3 0.1 1.8e-05 23.9 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 CRG89691.1 - 0.00013 21.4 0.1 0.00042 19.7 0.1 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 CRG89691.1 - 0.00019 20.9 0.0 0.041 13.2 0.0 2.3 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 CRG89691.1 - 0.0011 19.0 0.0 0.0027 17.7 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 CRG89691.1 - 0.016 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 CRG89691.1 - 0.036 13.7 0.0 0.065 12.8 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Avl9 PF09794.9 CRG89692.1 - 2e-111 372.4 0.0 4.8e-55 186.8 0.0 2.2 1 1 1 2 2 2 2 Transport protein Avl9 SPA PF08616.10 CRG89692.1 - 0.00034 20.6 0.0 0.00084 19.3 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis DUF2347 PF09804.9 CRG89692.1 - 0.0058 16.3 3.4 0.074 12.6 0.0 3.2 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2347) Afi1 PF07792.12 CRG89692.1 - 0.17 12.4 0.0 0.17 12.4 0.0 3.8 3 1 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF3439 PF11921.8 CRG89692.1 - 0.51 10.3 5.2 1.5 8.8 5.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Alveol-reg_P311 PF11092.8 CRG89692.1 - 1.5 9.0 4.8 15 5.8 0.2 2.8 2 0 0 2 2 2 0 Neuronal protein 3.1 (p311) ADH_zinc_N PF00107.26 CRG89693.1 - 2.6e-07 30.7 0.0 5.1e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG89693.1 - 2.8e-06 27.1 0.0 0.00022 21.1 0.0 2.5 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain ABC_membrane_2 PF06472.15 CRG89694.1 - 1.9e-103 345.6 1.1 2.7e-103 345.1 1.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CRG89694.1 - 1.5e-18 67.6 0.0 5.3e-18 65.9 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 CRG89694.1 - 0.00013 21.9 0.0 0.00027 20.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 CRG89694.1 - 0.0056 17.2 0.4 0.015 15.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain Glyco_transf_22 PF03901.17 CRG89694.1 - 0.014 14.6 0.4 0.025 13.8 0.4 1.3 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family AAA_29 PF13555.6 CRG89694.1 - 0.02 14.7 0.0 0.056 13.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 CRG89694.1 - 0.047 13.1 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 CRG89694.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain RuvB_N PF05496.12 CRG89694.1 - 0.16 11.7 0.1 1.6 8.5 0.0 2.5 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain LRR_6 PF13516.6 CRG89695.1 - 0.0011 18.8 2.7 4.2 7.7 0.1 6.0 7 0 0 7 7 7 1 Leucine Rich repeat Ribosomal_L5e PF17144.4 CRG89696.1 - 4.3e-80 267.4 0.6 7.3e-80 266.7 0.6 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 CRG89696.1 - 5.7e-34 116.9 7.4 5.7e-34 116.9 7.4 2.1 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region HAD_2 PF13419.6 CRG89696.1 - 2.1e-06 27.9 0.0 7.5e-06 26.1 0.0 1.9 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG89696.1 - 0.0079 16.5 0.0 0.022 15.1 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG89696.1 - 0.014 15.5 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Beta-lactamase PF00144.24 CRG89697.1 - 1.3e-35 123.2 0.0 2e-35 122.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase NmrA PF05368.13 CRG89698.1 - 6.7e-18 65.1 0.0 9.3e-16 58.1 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family MRF_C1 PF13887.6 CRG89698.1 - 0.12 11.5 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 Transthyretin PF00576.21 CRG89698.1 - 0.15 12.7 0.0 80 4.0 0.0 3.0 2 1 1 3 3 3 0 HIUase/Transthyretin family FTA4 PF13093.6 CRG89700.1 - 3.3e-59 200.2 7.9 3.3e-59 200.2 7.9 1.8 2 0 0 2 2 2 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MnmE_helical PF12631.7 CRG89700.1 - 0.017 15.3 3.5 0.025 14.8 1.4 2.1 2 0 0 2 2 2 0 MnmE helical domain RRF_GI PF12614.8 CRG89700.1 - 0.079 13.1 0.3 0.079 13.1 0.3 2.9 3 0 0 3 3 3 0 Ribosome recycling factor DUF4047 PF13256.6 CRG89700.1 - 0.11 12.7 3.2 0.16 12.2 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) Corona_NSP4_C PF16348.5 CRG89700.1 - 0.17 12.7 0.0 1.1 10.1 0.0 2.2 2 0 0 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus SlyX PF04102.12 CRG89700.1 - 1.8 9.3 18.8 0.83 10.3 0.2 6.2 7 0 0 7 7 7 0 SlyX rhaM PF05336.13 CRG89701.1 - 2.1e-37 127.4 0.3 2.4e-37 127.3 0.3 1.0 1 0 0 1 1 1 1 L-rhamnose mutarotase DUF2794 PF10984.8 CRG89701.1 - 0.031 14.4 0.0 0.052 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2794) 2-Hacid_dh_C PF02826.19 CRG89702.1 - 1.2e-40 138.7 0.0 1.9e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG89702.1 - 2.7e-13 49.8 0.0 3.5e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GFO_IDH_MocA PF01408.22 CRG89702.1 - 0.035 14.9 0.0 0.066 14.0 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_2 PF03446.15 CRG89702.1 - 0.039 14.1 0.0 0.064 13.4 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CRG89702.1 - 0.045 14.3 0.1 0.11 13.0 0.0 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent UDPG_MGDP_dh_C PF03720.15 CRG89702.1 - 0.092 13.2 0.0 0.35 11.3 0.0 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain IlvN PF07991.12 CRG89702.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Pec_lyase_C PF00544.19 CRG89703.1 - 8.4e-16 58.2 8.5 2.6e-14 53.3 8.5 2.2 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 CRG89703.1 - 6.9e-07 29.2 8.1 0.00021 21.2 0.4 2.3 2 0 0 2 2 2 2 Right handed beta helix region Phage_attach PF05354.11 CRG89703.1 - 0.078 12.9 0.1 0.27 11.1 0.1 1.9 1 0 0 1 1 1 0 Phage Head-Tail Attachment MFS_1 PF07690.16 CRG89704.1 - 9.2e-27 93.9 30.1 1.5e-26 93.2 30.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Zn_clus PF00172.18 CRG89704.1 - 0.0078 16.3 2.8 0.015 15.4 2.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 CRG89705.1 - 9.5e-43 146.5 0.1 1.5e-42 145.9 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 CRG89705.1 - 5.7e-23 81.2 0.0 1.1e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 CRG89705.1 - 7.5e-17 61.7 3.4 2.3e-16 60.1 1.4 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 CRG89705.1 - 1.6e-16 60.1 0.0 6.2e-16 58.2 0.0 2.0 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 CRG89705.1 - 5.4e-16 58.3 0.1 2.5e-15 56.2 0.0 2.2 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain Fer2_BFD PF04324.15 CRG89705.1 - 3.4e-15 56.1 6.3 2.4e-11 43.8 5.3 2.9 2 0 0 2 2 2 2 BFD-like [2Fe-2S] binding domain NIR_SIR_ferr PF03460.17 CRG89705.1 - 1.2e-09 37.8 0.0 3.1e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rubredoxin_C PF18267.1 CRG89705.1 - 1.3e-06 28.2 0.6 0.008 16.1 0.1 3.4 3 0 0 3 3 3 2 Rubredoxin NAD+ reductase C-terminal domain NAD_binding_9 PF13454.6 CRG89705.1 - 0.00054 20.0 0.2 2.1 8.3 0.0 3.9 3 1 1 4 4 4 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CRG89705.1 - 0.018 14.1 2.5 0.16 11.0 0.1 2.4 2 1 1 3 3 3 0 FAD binding domain Rep_N PF08724.10 CRG89705.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Rep protein catalytic domain like Mo-co_dimer PF03404.16 CRG89706.1 - 7.3e-61 204.2 0.1 1.6e-60 203.1 0.1 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 CRG89706.1 - 7e-54 182.0 0.0 1.1e-53 181.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain FAD_binding_6 PF00970.24 CRG89706.1 - 1.4e-34 118.4 0.0 2.3e-34 117.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 CRG89706.1 - 7e-29 100.7 0.0 1.5e-28 99.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Cyt-b5 PF00173.28 CRG89706.1 - 3.9e-19 68.6 0.0 7.8e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 CRG89706.1 - 0.012 15.8 0.0 0.19 11.9 0.0 2.4 1 1 1 2 2 2 0 Ferric reductase NAD binding domain GCP_C_terminal PF04130.13 CRG89707.1 - 3.3e-72 243.6 0.0 5.9e-72 242.7 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 CRG89707.1 - 1.1e-47 163.1 0.1 2.1e-47 162.2 0.1 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal tRNA-synt_1b PF00579.25 CRG89707.1 - 0.092 12.0 0.0 0.19 11.0 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Eaf7 PF07904.13 CRG89708.1 - 3.2e-28 98.2 0.0 3.2e-28 98.2 0.0 2.5 2 0 0 2 2 2 1 Chromatin modification-related protein EAF7 NOA36 PF06524.12 CRG89708.1 - 3.4 6.9 10.2 6.2 6.0 10.2 1.5 1 0 0 1 1 1 0 NOA36 protein Iso_dh PF00180.20 CRG89709.1 - 1.1e-100 337.2 0.0 1.4e-100 336.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 CRG89709.1 - 0.014 15.2 0.0 0.031 14.1 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 HHH_2 PF12826.7 CRG89709.1 - 0.032 14.3 0.0 0.44 10.7 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif Sec5 PF15469.6 CRG89710.1 - 7.8e-38 130.2 0.0 2.1e-37 128.8 0.0 1.8 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 CRG89710.1 - 7.1e-07 29.2 0.1 2.9e-06 27.3 0.1 2.1 1 0 0 1 1 1 1 Vps51/Vps67 NADPH_Ox PF08414.10 CRG89710.1 - 0.094 13.1 0.5 13 6.1 0.0 3.0 3 0 0 3 3 3 0 Respiratory burst NADPH oxidase rRNA_processing PF08524.11 CRG89711.1 - 0.017 15.2 27.2 1.9 8.5 27.2 2.2 1 1 0 1 1 1 0 rRNA processing SelK_SelG PF10961.8 CRG89711.1 - 5.4 7.7 6.9 4.6 7.9 2.7 2.4 2 0 0 2 2 2 0 Selenoprotein SelK_SelG DUF4210 PF13915.6 CRG89712.1 - 6.7e-33 113.1 0.2 2.8e-32 111.1 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 CRG89712.1 - 2.8e-24 85.0 0.7 7.7e-24 83.6 0.7 1.8 1 0 0 1 1 1 1 Chromosome segregation during meiosis CAP_N PF01213.19 CRG89713.1 - 7.6e-112 373.9 0.1 7.6e-112 373.9 0.1 1.5 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 CRG89713.1 - 4e-56 189.0 0.8 6.2e-56 188.4 0.8 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 CRG89713.1 - 0.42 10.4 1.8 0.88 9.3 1.8 1.5 1 1 0 1 1 1 0 Tubulin binding cofactor C PfkB PF00294.24 CRG89714.1 - 1.2e-10 41.2 0.0 5e-10 39.2 0.0 1.9 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Ribonucleas_3_3 PF14622.6 CRG89716.1 - 2.6e-12 47.0 0.0 6.8e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 CRG89716.1 - 1.4e-08 35.2 0.0 4.4e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 CRG89716.1 - 4.4e-07 30.5 0.0 1.4e-06 28.9 0.0 1.9 1 0 0 1 1 1 1 Double-stranded RNA binding motif S36_mt PF10937.8 CRG89716.1 - 0.1 14.2 1.8 1.4 10.5 1.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S36, mitochondrial BSP PF04450.12 CRG89717.1 - 9.5e-74 247.6 0.0 1.1e-73 247.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase of plants and bacteria DUF2268 PF10026.9 CRG89717.1 - 0.012 15.2 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) Peptidase_M76 PF09768.9 CRG89717.1 - 0.027 14.2 0.1 0.04 13.7 0.1 1.2 1 0 0 1 1 1 0 Peptidase M76 family Peptidase_M91 PF14891.6 CRG89717.1 - 0.058 13.7 0.1 0.088 13.1 0.1 1.3 1 0 0 1 1 1 0 Effector protein ECH_1 PF00378.20 CRG89718.1 - 2.2e-42 145.1 0.0 3e-42 144.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG89718.1 - 4.1e-29 102.1 0.0 4.6e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Lactamase_B PF00753.27 CRG89719.1 - 5.5e-15 55.9 4.1 7.7e-15 55.4 4.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG89719.1 - 8e-07 28.8 0.6 1.2e-06 28.2 0.6 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain bZIP_1 PF00170.21 CRG89720.1 - 0.00043 20.3 0.9 0.00085 19.4 0.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor Tautomerase_3 PF14832.6 CRG89721.1 - 1.4e-41 141.9 0.2 1.6e-41 141.7 0.2 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme CLASP_N PF12348.8 CRG89722.1 - 4.9e-156 516.9 0.2 2.7e-91 305.2 0.0 2.3 2 0 0 2 2 2 2 CLASP N terminal HEAT PF02985.22 CRG89722.1 - 5e-05 23.2 0.0 0.61 10.5 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat UME PF08064.13 CRG89722.1 - 0.022 14.7 0.2 0.25 11.2 0.1 2.6 2 0 0 2 2 2 0 UME (NUC010) domain Cnd1 PF12717.7 CRG89722.1 - 0.024 14.7 0.0 4.5 7.3 0.0 3.4 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 CRG89722.1 - 0.036 14.0 1.4 0.37 10.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) HEAT_2 PF13646.6 CRG89722.1 - 0.053 13.9 4.4 2.7 8.4 0.0 4.5 5 1 1 6 6 6 0 HEAT repeats RhoGAP PF00620.27 CRG89723.1 - 1.7e-48 164.3 0.1 6.5e-48 162.4 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 CRG89723.1 - 8.1e-14 51.6 18.6 4e-09 36.6 2.7 2.4 2 0 0 2 2 2 2 LIM domain Fez1 PF06818.15 CRG89723.1 - 0.0092 16.5 12.4 0.0092 16.5 12.4 2.6 3 0 0 3 3 2 1 Fez1 CENP-H PF05837.12 CRG89723.1 - 0.017 15.5 1.2 0.017 15.5 1.2 3.7 3 0 0 3 3 3 0 Centromere protein H (CENP-H) DUF4686 PF15742.5 CRG89723.1 - 0.042 13.0 15.5 0.67 9.0 2.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4686) Hexokinase_1 PF00349.21 CRG89723.1 - 0.06 13.2 0.0 0.23 11.3 0.0 1.9 1 0 0 1 1 1 0 Hexokinase DUF536 PF04394.14 CRG89723.1 - 0.76 9.7 5.5 7.6 6.5 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function, DUF536 NPV_P10 PF05531.12 CRG89723.1 - 3.5 8.2 9.7 0.49 10.9 1.1 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TF_Zn_Ribbon PF08271.12 CRG89723.1 - 4 7.0 16.1 1.8 8.2 1.1 4.4 3 1 1 4 4 4 0 TFIIB zinc-binding TMF_TATA_bd PF12325.8 CRG89723.1 - 4.9 7.4 20.2 2.4 8.4 4.0 3.8 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding ZapB PF06005.12 CRG89723.1 - 5.2 7.6 17.2 5.5 7.5 5.5 3.1 2 0 0 2 2 2 0 Cell division protein ZapB Zn-ribbon_8 PF09723.10 CRG89723.1 - 5.2 7.3 20.0 0.92 9.7 1.5 4.1 3 1 2 5 5 5 0 Zinc ribbon domain DASH_Ask1 PF08655.10 CRG89724.1 - 9.2e-31 105.5 0.3 1.4e-30 104.9 0.3 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 SBF2 PF12335.8 CRG89724.1 - 0.083 12.5 0.5 0.12 12.0 0.5 1.2 1 0 0 1 1 1 0 Myotubularin protein Caldesmon PF02029.15 CRG89725.1 - 0.17 10.6 11.7 0.23 10.2 11.7 1.2 1 0 0 1 1 1 0 Caldesmon PsbN PF02468.15 CRG89725.1 - 6.4 6.7 6.7 29 4.6 1.8 2.4 2 0 0 2 2 2 0 Photosystem II reaction centre N protein (psbN) LicD PF04991.13 CRG89726.1 - 7.9e-23 81.8 9.1 2.5e-15 57.2 2.6 2.1 1 1 1 2 2 2 2 LicD family WLM PF08325.10 CRG89727.1 - 1.8e-51 174.9 0.0 3.5e-51 174.0 0.0 1.4 1 0 0 1 1 1 1 WLM domain DUF45 PF01863.17 CRG89727.1 - 5.2e-05 23.4 0.5 0.0001 22.4 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function DUF45 SprT-like PF10263.9 CRG89727.1 - 0.011 15.5 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 0 SprT-like family Thiolase_N PF00108.23 CRG89728.1 - 1.9e-70 237.2 0.1 2.8e-70 236.6 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG89728.1 - 3.9e-42 142.8 0.1 3.9e-42 142.8 0.1 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CRG89728.1 - 7.7e-05 22.4 1.4 0.00074 19.2 1.3 2.3 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 CRG89728.1 - 0.013 15.7 0.4 0.039 14.1 0.0 2.0 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ACP_syn_III PF08545.10 CRG89728.1 - 0.12 12.3 0.4 7.5 6.5 0.1 2.6 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Arylsulfotran_2 PF14269.6 CRG89730.1 - 3.1e-62 210.6 0.0 4e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CRG89730.1 - 7e-07 28.5 0.1 2.4e-06 26.7 0.1 1.9 2 1 0 2 2 2 1 Arylsulfotransferase (ASST) MFS_1 PF07690.16 CRG89731.1 - 6.7e-39 133.8 74.2 9.4e-32 110.3 55.9 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AA_permease_2 PF13520.6 CRG89732.1 - 3.9e-39 134.7 42.3 4.5e-39 134.5 42.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG89732.1 - 3.2e-12 45.8 35.3 4.7e-12 45.2 35.3 1.2 1 0 0 1 1 1 1 Amino acid permease CrgA PF06781.12 CRG89732.1 - 0.2 11.7 0.1 0.2 11.7 0.1 3.8 4 0 0 4 4 4 0 Cell division protein CrgA Fungal_trans_2 PF11951.8 CRG89733.1 - 1.6e-27 96.3 1.3 4.8e-26 91.5 1.3 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain PhyH PF05721.13 CRG89734.1 - 7.7e-13 49.2 0.1 2.5e-12 47.5 0.1 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) PhyH PF05721.13 CRG89735.1 - 1.1e-23 84.6 0.0 1.7e-23 84.0 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Phage_lysozyme PF00959.19 CRG89736.1 - 6e-14 52.4 0.0 7.8e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Phage lysozyme HSP70 PF00012.20 CRG89737.1 - 6.6e-166 553.0 6.5 6.6e-166 553.0 6.5 2.7 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 CRG89737.1 - 4.1e-12 45.6 0.0 1.9e-11 43.4 0.0 1.9 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 CRG89737.1 - 0.017 15.5 0.0 3.4 8.1 0.0 3.2 2 1 0 2 2 2 0 Cell division protein FtsA Ketoacyl-synt_C PF02801.22 CRG89737.1 - 0.035 14.1 0.0 0.16 12.0 0.0 2.1 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Trans_reg_C PF00486.28 CRG89737.1 - 0.12 12.5 0.1 1.7 8.8 0.0 2.6 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal PEP_mutase PF13714.6 CRG89738.1 - 1.1e-63 214.9 1.2 1.2e-63 214.7 1.2 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Methyltrans_RNA PF04452.14 CRG89738.1 - 0.063 12.6 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 0 RNA methyltransferase T2SS-T3SS_pil_N PF13629.6 CRG89738.1 - 0.12 12.1 0.2 0.44 10.3 0.1 2.0 2 0 0 2 2 2 0 Pilus formation protein N terminal region Chitin_synth_2 PF03142.15 CRG89739.1 - 4.6e-20 71.7 3.6 4.6e-20 71.7 3.6 2.6 2 1 1 3 3 3 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 CRG89739.1 - 4.5e-12 46.3 0.0 6.9e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CRG89739.1 - 7.9e-12 45.5 8.8 7.9e-12 45.5 8.8 2.8 2 2 1 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 CRG89739.1 - 0.00046 20.1 0.0 0.12 12.2 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 CybS PF05328.12 CRG89739.1 - 0.083 12.6 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 CybS, succinate dehydrogenase cytochrome B small subunit La PF05383.17 CRG89740.1 - 1.4e-19 69.9 0.0 2.4e-19 69.2 0.0 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 CRG89740.1 - 2.6e-07 30.4 0.2 5.8e-07 29.2 0.2 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dabb PF07876.12 CRG89741.1 - 2.1e-12 47.5 0.0 2.3e-12 47.4 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Glyco_hydro_61 PF03443.14 CRG89742.1 - 2.6e-67 226.7 0.0 4.6e-67 225.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 SUI1 PF01253.22 CRG89742.1 - 1.2e-17 64.2 0.0 2.8e-17 63.0 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 CRG89742.1 - 6.6e-08 33.1 0.2 2.7e-06 28.0 0.2 2.6 1 1 0 1 1 1 1 Pre-PUA-like domain TRAPPC10 PF12584.8 CRG89744.1 - 9.3e-39 132.6 0.0 6.9e-38 129.8 0.0 2.2 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 TIG PF01833.24 CRG89744.1 - 4.1e-09 36.4 0.4 4.1e-09 36.4 0.4 2.5 2 0 0 2 2 2 1 IPT/TIG domain Ank_5 PF13857.6 CRG89744.1 - 7.8e-07 29.3 0.7 0.00052 20.3 0.2 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG89744.1 - 1e-05 26.0 0.0 3.1e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG89744.1 - 3.9e-05 24.1 0.2 0.00035 21.1 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 CRG89744.1 - 0.0042 17.5 2.5 3.9 8.1 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Foie-gras_1 PF11817.8 CRG89744.1 - 0.0066 16.1 0.1 0.015 14.9 0.1 1.6 1 0 0 1 1 1 1 Foie gras liver health family 1 Ank_3 PF13606.6 CRG89744.1 - 0.074 13.6 0.5 9.3 7.2 0.2 3.1 3 0 0 3 3 3 0 Ankyrin repeat FA_desaturase PF00487.24 CRG89745.1 - 1.9e-24 86.9 17.5 4.4e-24 85.7 17.5 1.6 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 CRG89745.1 - 0.00073 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) Rad51 PF08423.11 CRG89746.1 - 2.3e-42 145.0 0.0 2.8e-39 134.9 0.0 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 CRG89746.1 - 7.5e-09 35.4 0.0 1.7e-08 34.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CRG89746.1 - 9.6e-09 34.9 0.1 6.4e-08 32.2 0.1 2.1 1 1 0 1 1 1 1 KaiC RecA PF00154.21 CRG89746.1 - 2.2e-05 24.1 0.2 0.00024 20.6 0.0 2.1 2 0 0 2 2 2 1 recA bacterial DNA recombination protein DnaB_C PF03796.15 CRG89746.1 - 0.0011 18.3 0.2 0.017 14.4 0.2 2.1 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_22 PF13401.6 CRG89746.1 - 0.013 15.7 0.0 0.026 14.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CRG89746.1 - 0.035 14.5 0.1 0.093 13.1 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain Pox_A32 PF04665.12 CRG89746.1 - 0.036 13.5 0.1 0.069 12.6 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein NACHT PF05729.12 CRG89746.1 - 0.18 11.7 0.1 0.78 9.6 0.1 2.1 1 1 0 1 1 1 0 NACHT domain Velvet PF11754.8 CRG89747.1 - 6.2e-49 167.2 0.2 1.6e-30 106.9 0.1 6.9 2 2 1 3 3 3 2 Velvet factor AA_permease_2 PF13520.6 CRG89748.1 - 3.9e-62 210.5 54.3 4.8e-62 210.2 54.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG89748.1 - 4.2e-31 108.1 49.6 5.6e-31 107.7 49.6 1.0 1 0 0 1 1 1 1 Amino acid permease TB2_DP1_HVA22 PF03134.19 CRG89748.1 - 0.094 12.7 2.2 0.5 10.3 2.2 2.3 1 0 0 1 1 1 0 TB2/DP1, HVA22 family Proton_antipo_N PF00662.20 CRG89748.1 - 0.16 12.0 3.6 0.2 11.7 0.0 3.1 3 0 0 3 3 3 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Gram_pos_anchor PF00746.21 CRG89748.1 - 2.3 8.3 4.9 58 3.8 0.0 3.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif JmjC PF02373.22 CRG89749.1 - 1.8e-36 125.0 0.8 5.9e-36 123.4 0.5 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 CRG89749.1 - 1.4e-19 70.3 3.0 2.4e-19 69.5 3.0 1.4 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CRG89749.1 - 1.5e-18 66.8 2.8 3.8e-18 65.5 2.8 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain JmjN PF02375.17 CRG89749.1 - 8.4e-15 54.4 0.5 2e-14 53.3 0.5 1.7 1 0 0 1 1 1 1 jmjN domain AA_permease PF00324.21 CRG89751.1 - 1.3e-113 380.2 42.1 1.5e-113 379.9 42.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG89751.1 - 6.7e-33 114.1 42.9 8.9e-33 113.7 42.9 1.0 1 0 0 1 1 1 1 Amino acid permease ADH_N PF08240.12 CRG89752.1 - 1.3e-22 79.7 0.1 3.3e-21 75.2 0.0 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89752.1 - 1.6e-20 73.4 0.0 2.6e-20 72.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG89752.1 - 1.1e-11 45.9 0.1 2e-11 45.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase IGFBP PF00219.18 CRG89752.1 - 0.0051 17.4 0.3 0.011 16.4 0.3 1.4 1 0 0 1 1 1 1 Insulin-like growth factor binding protein ADH_N_2 PF16884.5 CRG89752.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase OmdA PF13376.6 CRG89753.1 - 1.5e-14 53.7 0.3 3.3e-14 52.6 0.3 1.6 1 0 0 1 1 1 1 Bacteriocin-protection, YdeI or OmpD-Associated Alpha-amylase_C PF02806.18 CRG89754.1 - 8.6e-28 96.7 0.1 2e-27 95.5 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain Alpha-amylase PF00128.24 CRG89754.1 - 5.5e-16 59.1 0.0 6.9e-12 45.6 0.1 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain CBM_48 PF02922.18 CRG89754.1 - 5.3e-15 55.6 0.0 1.7e-14 53.9 0.0 2.0 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Aldo_ket_red PF00248.21 CRG89755.1 - 7e-65 219.1 0.0 8.9e-65 218.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Evf PF18270.1 CRG89755.1 - 0.063 12.7 0.0 0.26 10.7 0.0 1.8 2 0 0 2 2 2 0 Virulence factor Evf RHH_1 PF01402.21 CRG89755.1 - 0.15 12.0 3.4 0.63 10.1 0.2 3.0 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family APH PF01636.23 CRG89756.1 - 3.1e-10 40.4 0.0 3e-09 37.1 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG89756.1 - 3.7e-06 26.7 0.0 5.9e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF3632 PF12311.8 CRG89757.1 - 6.3e-30 104.9 2.3 1.2e-29 104.0 2.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3632) Carn_acyltransf PF00755.20 CRG89758.1 - 2.6e-209 696.7 0.0 9.1e-209 694.9 0.0 1.7 1 1 0 1 1 1 1 Choline/Carnitine o-acyltransferase Glyco_hydro_92 PF07971.12 CRG89759.1 - 4e-136 454.6 2.6 4.9e-136 454.3 2.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CRG89759.1 - 6.7e-50 170.2 5.4 1.1e-49 169.5 5.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Saf_2TM PF18303.1 CRG89759.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain UPF0160 PF03690.13 CRG89760.1 - 6.5e-124 413.7 0.0 7.3e-124 413.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Peptidase_M20 PF01546.28 CRG89761.1 - 1.8e-22 80.1 0.0 2.9e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG89761.1 - 2.5e-16 59.6 0.1 2e-14 53.4 0.0 2.6 2 0 0 2 2 2 1 Peptidase dimerisation domain DUF2218 PF09981.9 CRG89761.1 - 0.31 11.4 1.3 7.7 7.0 0.0 3.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2218) MFS_1 PF07690.16 CRG89762.1 - 6.3e-05 22.1 6.9 6.3e-05 22.1 6.9 2.7 1 1 0 2 2 2 2 Major Facilitator Superfamily PUCC PF03209.15 CRG89762.1 - 0.0025 16.9 3.4 0.0025 16.9 3.4 2.1 3 0 0 3 3 3 1 PUCC protein Dicty_CAR PF05462.11 CRG89763.1 - 2.7e-06 26.7 10.7 2.7e-06 26.7 10.7 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 CRG89763.1 - 0.00075 18.9 3.3 0.0012 18.2 3.1 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Ocular_alb PF02101.15 CRG89763.1 - 0.59 9.0 7.4 0.38 9.6 5.7 1.6 2 0 0 2 2 2 0 Ocular albinism type 1 protein Ras PF00071.22 CRG89764.1 - 3.2e-63 212.2 0.2 3.7e-63 212.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG89764.1 - 2.3e-35 121.4 0.2 3.1e-35 121.0 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG89764.1 - 7.4e-13 48.3 0.1 9.7e-13 47.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CRG89764.1 - 8.9e-08 32.2 0.1 1.4e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG89764.1 - 0.00015 21.7 0.2 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 CRG89764.1 - 0.00058 19.3 0.1 0.00091 18.7 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CRG89764.1 - 0.00064 19.3 0.2 0.0036 16.9 0.1 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 CRG89764.1 - 0.0027 18.0 0.0 0.019 15.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 CRG89764.1 - 0.014 14.9 0.0 0.022 14.2 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 CRG89764.1 - 0.017 15.2 0.1 0.051 13.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 CRG89764.1 - 0.017 15.5 0.1 0.029 14.7 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 CRG89764.1 - 0.021 15.4 0.1 0.03 14.8 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 CRG89764.1 - 0.023 14.4 0.1 0.06 13.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 CRG89764.1 - 0.05 13.0 0.0 0.17 11.3 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein FeoB_N PF02421.18 CRG89764.1 - 0.074 12.6 0.1 0.23 11.0 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_21 PF13304.6 CRG89764.1 - 0.12 12.2 0.6 0.17 11.7 0.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 CRG89764.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SpoIIID PF12116.8 CRG89764.1 - 0.13 12.4 0.1 2.8 8.1 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D DDE_3 PF13358.6 CRG89765.1 - 1.1e-16 61.0 0.0 1.7e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 CRG89765.1 - 4e-06 27.0 0.0 8.1e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Transposase HTH_32 PF13565.6 CRG89765.1 - 0.00031 21.3 0.0 0.0013 19.3 0.0 2.1 1 0 0 1 1 1 1 Homeodomain-like domain Ndc1_Nup PF09531.10 CRG89765.1 - 0.065 11.9 1.7 0.076 11.7 1.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spt20 PF12090.8 CRG89765.1 - 0.17 11.5 10.7 0.27 10.8 10.7 1.3 1 0 0 1 1 1 0 Spt20 family ADH_N PF08240.12 CRG89767.1 - 0.00011 22.0 0.0 0.00029 20.7 0.0 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 CRG89767.1 - 0.0045 16.9 0.0 0.0086 16.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CRG89767.1 - 0.02 14.9 0.1 0.045 13.7 0.0 1.6 2 0 0 2 2 2 0 Zinc-binding dehydrogenase Chromo PF00385.24 CRG89768.1 - 6.1e-10 38.9 2.5 6.1e-10 38.9 2.5 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain WD40 PF00400.32 CRG89769.1 - 7.4e-138 444.4 34.9 2.9e-12 46.9 0.2 13.4 13 0 0 13 13 13 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG89769.1 - 3.6e-52 174.6 4.1 6.1e-06 26.4 0.0 12.1 1 1 9 11 11 11 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG89769.1 - 2.7e-25 89.0 0.6 0.26 10.2 0.0 11.1 2 2 9 11 11 11 8 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CRG89769.1 - 7.8e-15 54.3 1.6 0.001 17.7 0.0 5.6 1 1 5 6 6 6 3 Cytochrome D1 heme domain WD40_like PF17005.5 CRG89769.1 - 2.5e-14 53.3 0.0 0.01 15.2 0.0 6.8 5 2 3 8 8 8 4 WD40-like domain Proteasome_A_N PF10584.9 CRG89769.1 - 3.6e-13 48.9 7.4 0.94 9.2 0.0 10.4 11 0 0 11 11 11 2 Proteasome subunit A N-terminal signature Frtz PF11768.8 CRG89769.1 - 7.9e-13 47.6 0.0 0.017 13.5 0.0 5.7 3 2 3 7 7 7 3 WD repeat-containing and planar cell polarity effector protein Fritz Ret2_MD PF18528.1 CRG89769.1 - 8.1e-10 38.9 0.0 18 5.8 0.0 10.1 9 3 3 12 12 12 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Nucleoporin_N PF08801.11 CRG89769.1 - 8.9e-09 34.6 9.6 1.4 7.6 0.2 6.8 2 2 5 7 7 7 4 Nup133 N terminal like PD40 PF07676.12 CRG89769.1 - 5e-08 32.7 15.3 13 5.9 0.1 11.1 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 CRG89769.1 - 2.5e-07 30.8 0.0 5.6e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG89769.1 - 0.00011 22.6 0.0 0.00081 19.8 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain Peptidase_S9_N PF02897.15 CRG89769.1 - 0.00066 18.6 5.7 3.2 6.4 0.1 6.4 2 2 6 8 8 8 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Coatomer_WDAD PF04053.14 CRG89769.1 - 0.016 14.3 0.1 2 7.3 0.0 3.2 1 1 2 3 3 3 0 Coatomer WD associated region AAA_18 PF13238.6 CRG89769.1 - 0.039 14.5 0.3 0.13 12.8 0.3 2.0 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 CRG89769.1 - 0.069 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain GSDH PF07995.11 CRG89769.1 - 0.075 12.3 0.0 2.9 7.1 0.0 3.3 2 1 1 3 3 3 0 Glucose / Sorbosone dehydrogenase AAA_22 PF13401.6 CRG89769.1 - 0.1 12.9 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CRG89769.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase CN_hydrolase PF00795.22 CRG89769.1 - 0.13 11.6 0.3 57 2.9 0.0 4.1 3 2 1 4 4 4 0 Carbon-nitrogen hydrolase DS PF01916.17 CRG89769.1 - 0.14 11.4 0.0 0.31 10.2 0.0 1.5 1 0 0 1 1 1 0 Deoxyhypusine synthase DUF5570 PF17731.1 CRG89769.1 - 4.9 7.3 12.6 57 3.8 0.1 6.2 4 3 4 8 8 8 0 Family of unknown function (DUF5570) AAA_2 PF07724.14 CRG89770.1 - 2.9e-37 128.4 0.0 3.1e-36 125.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 CRG89770.1 - 8.8e-15 55.3 0.0 1.7e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 CRG89770.1 - 1.4e-10 41.1 0.1 4e-10 39.6 0.0 1.8 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 CRG89770.1 - 5.4e-07 29.7 0.0 1.2e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CRG89770.1 - 0.00045 19.7 0.1 0.015 14.7 0.0 3.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 CRG89770.1 - 0.00065 19.5 0.0 0.062 13.0 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 CRG89770.1 - 0.0018 18.6 0.2 0.019 15.2 0.2 2.3 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 CRG89770.1 - 0.0024 17.0 0.1 0.0049 16.0 0.1 1.5 1 0 0 1 1 1 1 MCM P-loop domain IstB_IS21 PF01695.17 CRG89770.1 - 0.0047 16.7 0.0 0.0086 15.8 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CRG89770.1 - 0.0066 16.8 0.1 0.019 15.4 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 CRG89770.1 - 0.01 15.6 0.1 0.072 12.8 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 CRG89770.1 - 0.016 15.4 0.3 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 CRG89770.1 - 0.017 14.9 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CRG89770.1 - 0.027 14.0 0.0 0.049 13.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 CRG89770.1 - 0.051 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CRG89770.1 - 0.066 13.6 0.0 0.2 12.1 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 CRG89770.1 - 0.1 13.1 0.1 0.32 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 CRG89770.1 - 0.16 12.5 0.0 0.33 11.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 CRG89770.1 - 0.16 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 CRG89770.1 - 0.2 11.7 0.0 0.47 10.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain DLH PF01738.18 CRG89771.1 - 1.6e-12 47.5 0.1 3.2e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Zn_clus PF00172.18 CRG89773.1 - 1.2e-05 25.3 11.5 1.2e-05 25.3 11.5 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG89773.1 - 3.6e-05 22.8 0.1 0.0033 16.3 0.0 2.1 2 0 0 2 2 2 2 Fungal specific transcription factor domain Git3 PF11710.8 CRG89774.1 - 7e-25 88.0 11.5 1.7e-24 86.7 11.5 1.7 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 CRG89774.1 - 4.3e-10 39.5 1.0 1.4e-09 37.9 0.1 2.4 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 CRG89774.1 - 0.11 11.6 12.9 0.18 10.9 12.9 1.4 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor NAM-associated PF14303.6 CRG89774.1 - 0.38 11.5 9.4 0.71 10.6 9.4 1.4 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain SR-25 PF10500.9 CRG89774.1 - 5.5 6.5 45.0 78 2.8 45.0 2.1 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4663 PF15668.5 CRG89774.1 - 6.1 5.8 9.6 9.2 5.2 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) Peptidase_S64 PF08192.11 CRG89774.1 - 7.8 4.8 13.9 11 4.3 13.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 WW PF00397.26 CRG89775.1 - 4.3e-07 29.9 0.4 8.9e-07 28.9 0.4 1.6 1 0 0 1 1 1 1 WW domain Brix PF04427.18 CRG89776.1 - 4.8e-30 105.1 0.0 1e-29 104.0 0.0 1.5 1 0 0 1 1 1 1 Brix domain F-box-like PF12937.7 CRG89776.1 - 0.0069 16.3 0.2 0.018 14.9 0.2 1.7 1 0 0 1 1 1 1 F-box-like NAD_binding_2 PF03446.15 CRG89776.1 - 0.2 11.8 0.1 0.89 9.7 0.0 2.0 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F-box-like PF12937.7 CRG89777.1 - 0.015 15.2 0.3 0.029 14.3 0.3 1.5 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 CRG89777.1 - 0.15 12.5 0.6 7.2 7.2 0.6 3.3 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Abp2 PF09441.10 CRG89779.1 - 2.7e-84 281.4 0.0 4.6e-84 280.7 0.0 1.4 1 0 0 1 1 1 1 ARS binding protein 2 PG_isomerase_N PF18353.1 CRG89782.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphoglucose isomerase N-terminal domain NADHdh_A3 PF14987.6 CRG89782.1 - 6.3 7.2 10.7 0.16 12.3 2.5 2.6 3 1 1 4 4 4 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 Myb_DNA-binding PF00249.31 CRG89783.1 - 0.00024 21.3 0.3 0.00074 19.7 0.0 2.0 2 1 0 2 2 2 1 Myb-like DNA-binding domain ORC6 PF05460.13 CRG89783.1 - 0.0067 15.7 3.7 0.0072 15.6 3.7 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) Pox_Ag35 PF03286.14 CRG89783.1 - 0.062 13.1 11.3 0.075 12.8 11.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Myb_DNA-binding PF00249.31 CRG89784.1 - 4.7e-10 39.5 0.1 6.9e-07 29.4 0.0 2.4 2 1 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG89784.1 - 0.011 15.9 0.0 1.3 9.3 0.0 2.3 1 1 1 2 2 2 0 Myb-like DNA-binding domain DUP PF00674.18 CRG89784.1 - 0.078 13.1 0.2 5.9 7.1 0.2 2.2 1 1 1 2 2 2 0 DUP family HEPN_SAV2148 PF18725.1 CRG89784.1 - 0.13 11.6 0.1 0.32 10.4 0.0 1.7 1 1 1 2 2 2 0 SAV2148-like HEPN Myb_DNA-binding PF00249.31 CRG89785.1 - 0.0016 18.6 0.0 0.0022 18.2 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain MID_MedPIWI PF18296.1 CRG89787.1 - 0.16 11.7 2.2 0.2 11.4 2.2 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Glyco_hydro_31 PF01055.26 CRG89788.1 - 1.2e-108 364.2 4.0 1.9e-108 363.5 4.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CRG89788.1 - 1.7e-16 60.3 0.0 6.8e-16 58.3 0.1 2.1 2 0 0 2 2 2 1 Galactose mutarotase-like PAP_assoc PF03828.19 CRG89788.1 - 7.9e-13 48.4 0.2 2.1e-12 47.0 0.2 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 CRG89788.1 - 2.5e-06 27.7 0.0 7.4e-06 26.2 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Draxin PF15550.6 CRG89788.1 - 0.026 14.4 0.6 0.061 13.2 0.6 1.5 1 0 0 1 1 1 0 Draxin TMEM171 PF15471.6 CRG89788.1 - 0.077 12.0 2.4 0.15 11.0 2.4 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Mito_fiss_reg PF05308.11 CRG89788.1 - 0.63 10.1 14.3 0.025 14.6 8.1 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator GFA PF04828.14 CRG89789.1 - 3.7e-20 72.1 15.6 1.3e-10 41.5 1.5 2.6 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme DUF3246 PF11596.8 CRG89789.1 - 0.053 13.0 2.1 0.075 12.5 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Phage_base_V PF04717.12 CRG89789.1 - 0.1 12.5 0.2 3.7 7.5 0.0 3.1 3 1 0 3 3 3 0 Type VI secretion system, phage-baseplate injector FYVE_2 PF02318.16 CRG89789.1 - 7.9 6.7 8.7 2.6 8.3 4.2 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger NOB1_Zn_bind PF08772.11 CRG89789.1 - 9.2 6.5 9.6 4.3 7.6 1.8 2.9 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like PRKCSH-like PF12999.7 CRG89790.1 - 9.6e-47 159.0 9.9 1.6e-43 148.6 9.9 2.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 CRG89790.1 - 3.3e-30 104.8 1.6 3.3e-30 104.8 1.6 2.5 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 CRG89790.1 - 2.4e-09 38.0 0.7 7.9e-09 36.4 0.7 2.0 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Fib_alpha PF08702.10 CRG89790.1 - 0.001 19.2 7.4 0.061 13.5 1.3 2.7 3 0 0 3 3 3 2 Fibrinogen alpha/beta chain family CASP_C PF08172.12 CRG89790.1 - 0.0066 15.8 4.6 0.0066 15.8 4.6 1.5 2 0 0 2 2 2 1 CASP C terminal DUF3570 PF12094.8 CRG89790.1 - 0.071 11.9 0.0 0.13 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3570) Thiol_cytolys_C PF17440.2 CRG89790.1 - 0.13 12.5 0.7 0.36 11.0 0.7 1.7 1 0 0 1 1 1 0 Thiol-activated cytolysin beta sandwich domain DUF16 PF01519.16 CRG89790.1 - 0.14 12.6 7.3 0.17 12.4 4.5 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 Phage_HK97_TLTM PF06120.11 CRG89790.1 - 0.59 9.3 14.0 0.87 8.7 0.2 3.0 2 1 1 3 3 3 0 Tail length tape measure protein Fzo_mitofusin PF04799.13 CRG89790.1 - 2.9 7.4 5.2 1.5 8.4 2.1 2.0 2 0 0 2 2 2 0 fzo-like conserved region ATG27 PF09451.10 CRG89790.1 - 3.3 7.5 8.0 0.094 12.6 1.5 1.7 2 0 0 2 2 2 0 Autophagy-related protein 27 BST2 PF16716.5 CRG89790.1 - 4 8.1 12.2 6.2 7.5 3.7 3.2 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 UPF0242 PF06785.11 CRG89790.1 - 5.8 7.0 12.4 6.9 6.7 7.6 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Rtf2 PF04641.12 CRG89791.1 - 5.3e-67 225.9 7.6 6.1e-67 225.7 7.6 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 CRG89791.1 - 5.7e-09 35.7 0.0 0.00025 20.8 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 CRG89791.1 - 0.00089 19.3 0.0 0.0027 17.8 0.0 1.8 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_5 PF14634.6 CRG89791.1 - 0.0017 18.3 0.1 0.004 17.1 0.1 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CRG89791.1 - 0.0042 17.1 0.2 0.02 14.9 0.0 2.2 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CRG89791.1 - 0.036 13.9 0.3 0.092 12.6 0.3 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG89791.1 - 0.072 13.4 0.1 0.26 11.7 0.1 2.0 1 1 1 2 2 2 0 Ring finger domain zf-RING_11 PF17123.5 CRG89791.1 - 0.087 12.6 0.2 0.56 10.0 0.0 2.2 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 CRG89791.1 - 0.1 12.5 1.2 0.53 10.2 0.3 2.4 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Gastrin PF00918.17 CRG89791.1 - 0.81 10.7 7.4 0.095 13.7 1.6 2.2 2 1 1 3 3 3 0 Gastrin/cholecystokinin family Ribosomal_L50 PF10501.9 CRG89792.1 - 4e-17 62.3 0.0 9.4e-17 61.2 0.0 1.6 1 0 0 1 1 1 1 Ribosomal subunit 39S Thiolase_N PF00108.23 CRG89794.1 - 3.6e-78 262.5 0.3 5.5e-78 261.9 0.3 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG89794.1 - 1.9e-44 150.2 0.9 4.6e-44 149.0 0.9 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CRG89794.1 - 0.00058 19.5 1.5 0.0017 18.0 0.4 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CRG89794.1 - 0.09 12.6 0.5 4.9 7.1 0.1 2.4 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DAHP_synth_1 PF00793.20 CRG89796.1 - 1e-99 332.9 0.0 1.2e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family COX14 PF14880.6 CRG89797.1 - 1.6e-16 59.9 0.1 4.4e-16 58.5 0.1 1.8 1 0 0 1 1 1 1 Cytochrome oxidase c assembly DUF2458 PF10454.9 CRG89798.1 - 8.4e-51 172.0 3.0 1.4e-50 171.3 3.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) Nop25 PF09805.9 CRG89798.1 - 0.00078 19.9 2.2 0.0014 19.1 2.2 1.5 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) TFIIA PF03153.13 CRG89798.1 - 1.5 8.8 8.9 1.7 8.6 8.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Hexokinase_2 PF03727.16 CRG89799.1 - 2.6e-58 197.3 0.0 3.8e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 CRG89799.1 - 2.4e-45 154.9 0.0 4.5e-45 154.0 0.0 1.4 1 0 0 1 1 1 1 Hexokinase Aminopep PF10023.9 CRG89799.1 - 0.076 12.4 0.2 0.12 11.7 0.2 1.2 1 0 0 1 1 1 0 Putative aminopeptidase Hva1_TUDOR PF11160.8 CRG89800.1 - 2.3e-12 46.9 0.6 3.2e-12 46.4 0.6 1.2 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain PNP_UDP_1 PF01048.20 CRG89802.1 - 8.8e-10 38.2 0.3 2.9e-09 36.6 0.3 1.8 1 1 0 1 1 1 1 Phosphorylase superfamily F-box_4 PF15966.5 CRG89802.1 - 0.0033 17.3 0.1 0.013 15.4 0.2 1.9 2 0 0 2 2 2 1 F-box Occludin_ELL PF07303.13 CRG89802.1 - 0.41 11.4 2.0 14 6.5 0.1 3.3 3 0 0 3 3 3 0 Occludin homology domain AAA PF00004.29 CRG89803.1 - 1.4e-53 180.8 0.0 3e-43 147.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 CRG89803.1 - 6.2e-29 100.2 0.3 1.5e-28 99.0 0.3 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 CRG89803.1 - 3.4e-16 58.8 0.1 8.5e-09 35.1 0.0 2.9 2 0 0 2 2 2 2 AAA+ lid domain NACHT PF05729.12 CRG89803.1 - 5.8e-12 45.8 1.9 8.5e-09 35.5 0.2 3.3 3 0 0 3 3 3 2 NACHT domain AAA_2 PF07724.14 CRG89803.1 - 7.1e-08 32.8 0.0 0.0079 16.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 CRG89803.1 - 2.4e-07 31.3 9.2 0.0018 18.7 0.1 4.7 4 2 2 6 6 4 2 AAA ATPase domain AAA_22 PF13401.6 CRG89803.1 - 7.2e-07 29.6 1.6 0.01 16.1 0.1 3.6 2 2 1 3 3 3 2 AAA domain AAA_14 PF13173.6 CRG89803.1 - 1.2e-06 28.6 0.0 0.003 17.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 CRG89803.1 - 1.6e-06 28.2 0.0 0.0035 17.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 CRG89803.1 - 1.1e-05 25.3 0.0 0.0094 15.7 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CRG89803.1 - 1.3e-05 25.8 0.1 0.029 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CRG89803.1 - 2.6e-05 24.2 0.2 0.19 11.7 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CRG89803.1 - 3.2e-05 23.7 0.1 0.03 14.1 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_17 PF13207.6 CRG89803.1 - 0.00013 22.4 1.9 0.32 11.4 0.0 3.2 4 0 0 4 4 2 2 AAA domain AAA_7 PF12775.7 CRG89803.1 - 0.00017 21.1 0.0 0.0074 15.8 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 CRG89803.1 - 0.00022 21.4 0.4 0.16 12.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_28 PF13521.6 CRG89803.1 - 0.00041 20.6 0.1 0.22 11.8 0.1 2.6 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 CRG89803.1 - 0.00061 19.6 0.0 0.31 10.8 0.0 2.5 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 CRG89803.1 - 0.00078 18.9 0.2 0.19 11.1 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 CRG89803.1 - 0.00095 19.7 0.4 0.34 11.4 0.0 2.9 3 0 0 3 3 2 1 ABC transporter NTPase_1 PF03266.15 CRG89803.1 - 0.0013 18.7 0.1 0.018 15.0 0.0 2.2 2 0 0 2 2 2 1 NTPase Zeta_toxin PF06414.12 CRG89803.1 - 0.0021 17.3 0.0 0.89 8.8 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.6 CRG89803.1 - 0.0037 17.6 0.5 0.05 13.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 CRG89803.1 - 0.0041 17.1 0.0 0.2 11.5 0.0 2.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 CRG89803.1 - 0.0043 17.4 0.0 3.3 8.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase ATPase PF06745.13 CRG89803.1 - 0.0043 16.4 0.0 0.28 10.5 0.0 2.3 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.6 CRG89803.1 - 0.0077 15.8 3.2 2.8 7.5 0.2 3.6 2 2 2 4 4 4 1 AAA domain PEX-2N PF09263.10 CRG89803.1 - 0.01 16.1 0.8 0.26 11.6 0.8 2.6 1 1 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal Rad17 PF03215.15 CRG89803.1 - 0.011 15.6 0.0 6.6 6.6 0.1 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain PduV-EutP PF10662.9 CRG89803.1 - 0.012 15.4 0.1 0.28 10.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 CRG89803.1 - 0.012 15.2 1.0 0.42 10.2 0.1 2.6 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain KAP_NTPase PF07693.14 CRG89803.1 - 0.012 14.8 0.1 0.071 12.3 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain AAA_29 PF13555.6 CRG89803.1 - 0.014 15.1 0.2 0.15 11.8 0.3 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 CRG89803.1 - 0.019 14.0 0.1 0.057 12.5 0.1 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_30 PF13604.6 CRG89803.1 - 0.021 14.5 0.1 0.23 11.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 CRG89803.1 - 0.054 12.7 0.1 11 5.1 0.1 2.4 2 0 0 2 2 2 0 NB-ARC domain Cytidylate_kin2 PF13189.6 CRG89803.1 - 0.077 13.1 0.0 5.2 7.2 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase-like family TIP49 PF06068.13 CRG89803.1 - 0.087 12.0 0.0 1.3 8.2 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 CRG89803.1 - 0.095 12.4 0.0 4.4 7.0 0.0 2.6 2 1 0 2 2 2 0 Sigma-54 interaction domain SKI PF01202.22 CRG89803.1 - 0.13 12.4 0.0 20 5.3 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase SRP54 PF00448.22 CRG89803.1 - 0.14 11.8 0.2 0.4 10.3 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CRG89803.1 - 0.15 11.8 0.1 20 4.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 CRG89803.1 - 0.16 11.6 0.0 0.4 10.3 0.0 1.6 1 0 0 1 1 1 0 Thymidylate kinase ATP_bind_1 PF03029.17 CRG89803.1 - 0.22 11.3 0.1 0.69 9.7 0.0 1.9 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein MCM PF00493.23 CRG89804.1 - 2.1e-103 344.3 0.0 3.3e-103 343.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CRG89804.1 - 2.2e-33 114.8 0.2 3.9e-33 114.0 0.2 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 CRG89804.1 - 3.7e-22 78.9 0.5 9.4e-22 77.6 0.5 1.8 1 0 0 1 1 1 1 MCM N-terminal domain MCM_lid PF17855.1 CRG89804.1 - 8.5e-22 77.4 0.3 2.1e-21 76.1 0.3 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 CRG89804.1 - 3.1e-07 30.0 0.0 2.1e-05 24.0 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 CRG89804.1 - 1e-06 28.8 0.0 4e-06 26.9 0.0 2.1 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 CRG89804.1 - 0.0041 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 CRG89804.1 - 0.023 14.6 0.0 0.084 12.7 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CRG89804.1 - 0.17 11.6 0.0 0.8 9.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA PF00004.29 CRG89804.1 - 0.19 12.2 0.3 5.6 7.4 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AMP-binding PF00501.28 CRG89805.1 - 4.1e-94 315.6 0.0 4.8e-94 315.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG89805.1 - 2.6e-10 41.1 0.1 5.3e-10 40.1 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans_2 PF11951.8 CRG89806.1 - 9.5e-33 113.5 0.2 1.6e-32 112.8 0.2 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Cu_amine_oxid PF01179.20 CRG89807.1 - 1.9e-165 550.8 0.1 2.3e-165 550.5 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 CRG89807.1 - 8.9e-07 29.1 0.1 1.9e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 CRG89807.1 - 0.001 19.5 0.0 0.0022 18.4 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain DUF5026 PF16429.5 CRG89807.1 - 0.066 13.3 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5026) CMAS PF02353.20 CRG89808.1 - 3.3e-61 207.0 0.0 4.4e-61 206.6 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CRG89808.1 - 7.9e-09 35.6 0.0 1.5e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89808.1 - 1.3e-08 35.4 0.0 2.7e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89808.1 - 5.7e-08 33.3 0.0 1.2e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CRG89808.1 - 0.0053 16.3 0.0 0.0088 15.6 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 CRG89808.1 - 0.019 15.7 0.0 0.055 14.2 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89808.1 - 0.02 14.7 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 CRG89808.1 - 0.046 13.3 0.1 0.076 12.6 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 CRG89808.1 - 0.13 12.0 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CRG89808.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase MetW PF07021.12 CRG89808.1 - 0.17 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Tropomyosin_1 PF12718.7 CRG89810.1 - 3.7e-51 173.0 30.6 4.3e-51 172.8 30.6 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 CRG89810.1 - 1.3e-08 34.5 29.2 7.3e-06 25.5 16.7 2.5 1 1 1 2 2 2 2 Tropomyosin KLRAQ PF10205.9 CRG89810.1 - 0.00011 22.3 19.8 0.00022 21.4 6.7 2.9 1 1 2 3 3 3 1 Predicted coiled-coil domain-containing protein bZIP_1 PF00170.21 CRG89810.1 - 0.00014 21.8 24.9 0.024 14.7 0.4 4.3 2 1 2 4 4 4 2 bZIP transcription factor BLOC1_2 PF10046.9 CRG89810.1 - 0.00097 19.4 19.1 0.026 14.8 0.7 3.2 1 1 2 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 TACC_C PF05010.14 CRG89810.1 - 0.0012 18.7 23.0 0.013 15.3 16.8 2.1 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GAS PF13851.6 CRG89810.1 - 0.0026 17.1 27.1 0.019 14.3 21.3 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CRG89810.1 - 0.003 16.5 28.3 0.077 11.9 7.0 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein DUF724 PF05266.14 CRG89810.1 - 0.0038 17.1 21.6 0.0054 16.6 7.5 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF724) UPF0242 PF06785.11 CRG89810.1 - 0.0041 17.3 27.6 0.027 14.6 10.1 2.0 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Uso1_p115_C PF04871.13 CRG89810.1 - 0.0048 17.3 29.7 0.23 11.8 15.4 2.1 1 1 1 2 2 2 2 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.6 CRG89810.1 - 0.0049 16.3 19.4 0.028 13.8 13.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.9 CRG89810.1 - 0.005 17.1 28.4 0.0052 17.0 20.2 2.1 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 Myosin_tail_1 PF01576.19 CRG89810.1 - 0.0066 14.3 25.2 0.0079 14.1 25.2 1.0 1 0 0 1 1 1 1 Myosin tail ADIP PF11559.8 CRG89810.1 - 0.01 16.0 27.1 0.62 10.1 5.8 3.0 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 CRG89810.1 - 0.014 15.9 34.3 0.024 15.1 22.7 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 CRG89810.1 - 0.02 15.0 13.9 0.15 12.1 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) BST2 PF16716.5 CRG89810.1 - 0.02 15.5 23.7 0.033 14.8 8.6 3.0 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 EzrA PF06160.12 CRG89810.1 - 0.021 13.0 21.2 0.033 12.4 7.9 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA MS_channel PF00924.18 CRG89810.1 - 0.022 14.3 1.1 0.028 13.9 1.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel CLZ PF16526.5 CRG89810.1 - 0.029 14.7 19.5 0.49 10.8 6.3 3.3 1 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MAD PF05557.13 CRG89810.1 - 0.032 12.6 25.1 0.1 10.9 25.1 1.6 1 1 0 1 1 1 0 Mitotic checkpoint protein ERM PF00769.19 CRG89810.1 - 0.035 13.9 29.0 0.019 14.8 14.8 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF4200 PF13863.6 CRG89810.1 - 0.043 14.2 26.8 0.22 11.9 14.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ATG16 PF08614.11 CRG89810.1 - 0.045 14.0 27.7 1.6 8.9 13.8 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Qua1 PF16274.5 CRG89810.1 - 0.059 13.2 0.3 0.059 13.2 0.3 2.7 2 1 1 3 3 2 0 Qua1 domain VGPC1_C PF16799.5 CRG89810.1 - 0.065 13.2 6.9 0.45 10.5 1.7 2.8 2 1 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 Cep57_CLD_2 PF14197.6 CRG89810.1 - 0.067 13.3 25.1 1.9 8.7 0.6 4.2 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 Ubiquitin_4 PF18036.1 CRG89810.1 - 0.068 13.2 2.3 0.097 12.7 0.8 2.1 1 1 1 2 2 2 0 Ubiquitin-like domain SlyX PF04102.12 CRG89810.1 - 0.092 13.4 18.9 3.5 8.3 2.1 3.6 1 1 2 3 3 3 0 SlyX TMF_TATA_bd PF12325.8 CRG89810.1 - 0.11 12.8 24.4 0.2 11.9 14.1 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.6 CRG89810.1 - 0.12 12.2 27.5 1.1 9.1 26.1 2.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH SOGA PF11365.8 CRG89810.1 - 0.13 13.4 21.2 0.47 11.6 9.3 3.1 1 1 2 3 3 3 0 Protein SOGA Fez1 PF06818.15 CRG89810.1 - 0.13 12.7 23.4 1.4 9.3 23.3 1.9 1 1 0 1 1 1 0 Fez1 CENP-F_leu_zip PF10473.9 CRG89810.1 - 0.16 12.0 28.4 0.93 9.5 8.4 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TANGO2 PF05742.12 CRG89810.1 - 0.17 11.9 6.4 0.21 11.6 6.2 1.3 1 1 0 1 1 1 0 Transport and Golgi organisation 2 FlaC_arch PF05377.11 CRG89810.1 - 0.2 12.1 19.5 0.5 10.8 3.7 4.3 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) Laminin_II PF06009.12 CRG89810.1 - 0.24 11.4 17.5 0.071 13.1 6.7 2.3 1 1 1 2 2 2 0 Laminin Domain II ZapB PF06005.12 CRG89810.1 - 0.29 11.6 33.1 0.15 12.5 8.1 3.4 1 1 1 3 3 3 0 Cell division protein ZapB DUF812 PF05667.11 CRG89810.1 - 0.32 9.9 24.9 3.5 6.4 25.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF4201 PF13870.6 CRG89810.1 - 0.35 10.6 24.7 3.4 7.4 19.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) FAM76 PF16046.5 CRG89810.1 - 0.61 9.4 21.0 0.9 8.8 6.1 2.1 1 1 1 2 2 2 0 FAM76 protein TPR_MLP1_2 PF07926.12 CRG89810.1 - 0.64 10.1 32.0 0.33 11.0 6.9 2.8 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HAP1_N PF04849.13 CRG89810.1 - 0.73 9.0 25.9 19 4.3 25.9 2.4 1 1 0 1 1 1 0 HAP1 N-terminal conserved region FapA PF03961.13 CRG89810.1 - 0.88 8.1 21.8 0.14 10.8 9.0 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF1640 PF07798.11 CRG89810.1 - 1 9.4 22.2 0.35 10.9 6.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF3450 PF11932.8 CRG89810.1 - 1.2 8.3 24.3 3.4 6.9 10.2 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) CHDCT2 PF08074.11 CRG89810.1 - 1.2 9.2 9.5 0.53 10.4 5.2 2.0 1 1 0 2 2 2 0 CHDCT2 (NUC038) domain TMF_DNA_bd PF12329.8 CRG89810.1 - 1.3 9.1 31.2 1.4 9.0 8.7 3.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding OmpH PF03938.14 CRG89810.1 - 1.6 9.0 27.7 2.9 8.2 18.3 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) PRKG1_interact PF15898.5 CRG89810.1 - 1.7 9.6 25.5 4.5 8.2 18.0 2.9 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain HMMR_N PF15905.5 CRG89810.1 - 1.7 8.0 28.1 6.5 6.1 28.1 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF2203 PF09969.9 CRG89810.1 - 1.8 9.3 16.7 9.1 7.0 5.5 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fmp27_WPPW PF10359.9 CRG89810.1 - 2 7.1 21.1 0.073 11.9 9.0 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF4795 PF16043.5 CRG89810.1 - 2.3 7.8 23.3 2.7 7.5 16.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Sec34 PF04136.15 CRG89810.1 - 2.5 8.0 15.1 2.4 8.0 3.7 2.1 1 1 1 2 2 2 0 Sec34-like family DUF5320 PF17253.2 CRG89810.1 - 2.5 9.2 18.2 2.4 9.3 2.8 3.3 3 1 0 3 3 3 0 Family of unknown function (DUF5320) Syntaxin-6_N PF09177.11 CRG89810.1 - 2.5 8.7 20.7 7.8 7.1 3.1 3.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Prefoldin_2 PF01920.20 CRG89810.1 - 2.7 8.0 29.1 2.5 8.1 6.3 3.9 1 1 1 3 3 3 0 Prefoldin subunit DUF5595 PF18077.1 CRG89810.1 - 2.8 8.1 21.3 0.94 9.6 4.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF5595) HAUS-augmin3 PF14932.6 CRG89810.1 - 2.8 7.4 25.4 2.4 7.7 12.6 2.4 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Cep57_MT_bd PF06657.13 CRG89810.1 - 3 8.4 17.3 0.47 10.9 5.6 3.3 1 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 KELK PF15796.5 CRG89810.1 - 3.2 8.3 26.4 1.5 9.3 12.6 3.6 2 2 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase TMPIT PF07851.13 CRG89810.1 - 4.3 6.5 20.0 1.4 8.1 3.4 2.0 1 1 1 2 2 2 0 TMPIT-like protein Striatin PF08232.12 CRG89810.1 - 4.7 7.8 20.4 16 6.1 0.2 2.2 1 1 1 2 2 2 0 Striatin family GCN5L1 PF06320.13 CRG89810.1 - 4.8 7.4 18.5 1.3 9.2 2.8 2.1 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) DUF745 PF05335.13 CRG89810.1 - 5.5 6.7 19.1 2.1 8.0 5.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) V_ATPase_I PF01496.19 CRG89810.1 - 5.6 4.8 18.7 0.52 8.2 6.6 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family TolA_bind_tri PF16331.5 CRG89810.1 - 5.7 7.1 20.6 1.2 9.2 2.1 3.3 2 1 1 3 3 3 0 TolA binding protein trimerisation XhlA PF10779.9 CRG89810.1 - 5.7 7.2 23.9 1.9 8.7 4.6 3.9 1 1 3 4 4 4 0 Haemolysin XhlA Atg14 PF10186.9 CRG89810.1 - 6.1 5.8 19.4 15 4.5 19.4 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-H PF05837.12 CRG89810.1 - 6.7 7.2 24.1 3.8 8.0 9.6 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Cnn_1N PF07989.11 CRG89810.1 - 6.9 6.9 26.3 8.7 6.6 6.2 3.2 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 DHR10 PF18595.1 CRG89810.1 - 7.2 6.7 30.4 1.5e+02 2.4 12.8 3.0 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain FUSC PF04632.12 CRG89810.1 - 7.6 4.9 5.6 8 4.9 5.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Rootletin PF15035.6 CRG89810.1 - 8.8 6.3 27.1 1.9 8.5 5.5 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF948 PF06103.11 CRG89810.1 - 9 6.6 10.9 2e+03 -0.9 10.9 3.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) SpecificRecomb PF10136.9 CRG89810.1 - 9.6 4.4 8.0 11 4.1 8.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase Nop25 PF09805.9 CRG89811.1 - 9.2e-38 129.8 13.2 9.2e-38 129.8 13.2 2.5 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) Casc1_N PF15927.5 CRG89811.1 - 0.0069 16.1 11.9 0.0069 16.1 11.9 2.2 2 0 0 2 2 2 1 Cancer susceptibility candidate 1 N-terminus BRF1 PF07741.13 CRG89811.1 - 0.014 15.7 3.8 0.014 15.7 3.8 2.6 2 1 0 2 2 2 0 Brf1-like TBP-binding domain ATP-synt_S1 PF05827.12 CRG89812.1 - 0.00062 19.6 0.0 0.00092 19.1 0.0 1.3 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) Rrn6 PF10214.9 CRG89813.1 - 0.14 10.7 9.7 0.21 10.1 9.7 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor EXS PF03124.14 CRG89814.1 - 4e-105 351.8 13.7 4.6e-105 351.6 13.7 1.0 1 0 0 1 1 1 1 EXS family Pex2_Pex12 PF04757.14 CRG89815.1 - 1.6e-42 145.6 3.7 2.3e-42 145.1 3.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 CRG89815.1 - 5.1e-12 45.4 9.3 8.6e-12 44.7 9.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG89815.1 - 7.6e-11 41.7 7.4 1.2e-10 41.1 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG89815.1 - 9.3e-11 41.4 6.0 1.4e-10 40.9 6.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG89815.1 - 1.5e-10 41.2 10.3 2.4e-10 40.6 10.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CRG89815.1 - 7.5e-09 35.5 8.1 1.6e-08 34.4 8.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 CRG89815.1 - 1e-07 31.7 6.1 1.6e-07 31.1 6.1 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CRG89815.1 - 2.3e-07 30.6 6.7 3.9e-07 29.9 6.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CRG89815.1 - 3.4e-07 30.3 8.4 6.7e-07 29.4 8.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 CRG89815.1 - 8.9e-06 25.9 9.9 1.8e-05 24.9 9.7 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 CRG89815.1 - 0.00036 20.6 6.3 0.00061 19.9 6.3 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 U-box PF04564.15 CRG89815.1 - 0.0023 18.0 0.0 0.01 16.0 0.0 2.0 2 0 0 2 2 2 1 U-box domain zf-RING_6 PF14835.6 CRG89815.1 - 0.0077 16.1 2.4 0.014 15.2 2.4 1.3 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-Nse PF11789.8 CRG89815.1 - 0.02 14.7 3.2 0.037 13.9 3.2 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 CRG89815.1 - 0.03 14.3 3.6 0.06 13.4 3.4 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rtf2 PF04641.12 CRG89815.1 - 0.19 11.1 1.2 0.41 10.0 1.2 1.6 1 0 0 1 1 1 0 Rtf2 RING-finger zf-RING_4 PF14570.6 CRG89815.1 - 0.21 11.4 7.6 0.44 10.4 7.6 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain IBR PF01485.21 CRG89815.1 - 0.78 10.0 4.7 1.8 8.8 4.7 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DNA_pol_A_exo1 PF01612.20 CRG89816.1 - 1e-13 51.4 0.1 1e-13 51.4 0.1 1.7 2 0 0 2 2 2 1 3'-5' exonuclease BNIP2 PF12496.8 CRG89816.1 - 3.1 8.3 8.4 1.9 8.9 4.2 2.3 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 LSM PF01423.22 CRG89817.1 - 4.3e-22 77.6 0.1 4.7e-22 77.4 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 CRG89817.1 - 0.008 16.3 0.0 0.0096 16.0 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain AA_permease PF00324.21 CRG89818.1 - 8.5e-149 496.2 44.0 1e-148 495.9 44.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG89818.1 - 2.2e-38 132.2 43.9 2.7e-38 131.9 43.9 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 CRG89818.1 - 0.0078 15.1 0.6 0.0078 15.1 0.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4781) EbsA PF17255.2 CRG89818.1 - 2.2 8.6 4.4 5.7 7.3 4.4 1.7 1 0 0 1 1 1 0 EbsA-like protein RhoGAP PF00620.27 CRG89819.1 - 3.8e-16 59.3 0.4 9.6e-16 58.0 0.4 1.6 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 CRG89819.1 - 2.7e-10 40.2 0.0 6.3e-10 39.0 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 CRG89819.1 - 9.4e-09 35.4 0.0 2.9e-08 33.9 0.0 1.9 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain adh_short_C2 PF13561.6 CRG89820.1 - 3.2e-55 187.2 0.0 3.7e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89820.1 - 3.2e-40 137.7 0.0 4.2e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89820.1 - 6.2e-07 29.5 0.1 1.2e-06 28.5 0.1 1.5 1 1 0 1 1 1 1 KR domain WD40 PF00400.32 CRG89821.1 - 2.3e-51 170.6 9.3 1.2e-09 38.6 0.2 6.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG89821.1 - 4.7e-25 87.7 0.1 0.00014 22.1 0.0 5.8 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG89821.1 - 7.8e-14 51.4 4.1 0.012 14.6 0.0 5.9 2 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CRG89821.1 - 7.2e-06 25.8 4.6 3.9 7.5 0.1 5.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 CRG89821.1 - 7.3e-06 24.9 1.8 2.1 6.9 0.0 4.8 3 1 1 4 4 4 2 Nucleoporin Nup120/160 NACHT_N PF17100.5 CRG89821.1 - 3.4e-05 23.8 0.7 0.00018 21.4 0.7 2.0 1 1 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase Proteasome_A_N PF10584.9 CRG89821.1 - 4.2e-05 23.1 0.3 5.6 6.7 0.0 4.9 4 0 0 4 4 4 2 Proteasome subunit A N-terminal signature NACHT PF05729.12 CRG89821.1 - 0.00034 20.6 0.5 0.00088 19.2 0.5 1.7 1 0 0 1 1 1 1 NACHT domain Gmad1 PF10647.9 CRG89821.1 - 0.0072 16.1 2.2 13 5.4 0.0 3.3 1 1 2 3 3 3 0 Lipoprotein LpqB beta-propeller domain WD40_like PF17005.5 CRG89821.1 - 0.043 13.1 0.0 0.54 9.5 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain DUF3748 PF12566.8 CRG89821.1 - 0.076 13.0 0.1 16 5.5 0.0 4.0 2 1 2 5 5 5 0 Protein of unknown function (DUF3748) K1377 PF15352.6 CRG89821.1 - 0.21 9.8 0.3 0.57 8.4 0.2 1.7 2 0 0 2 2 2 0 Susceptibility to monomelic amyotrophy FlaE PF07559.14 CRG89821.1 - 0.6 10.7 5.0 4e+02 1.6 5.2 3.6 1 1 0 1 1 1 0 Flagellar basal body protein FlaE NYD-SP28_assoc PF14775.6 CRG89821.1 - 1.9 8.6 6.6 1.3e+02 2.8 0.0 5.3 6 0 0 6 6 6 0 Sperm tail C-terminal domain MR_MLE_C PF13378.6 CRG89822.1 - 6.2e-42 143.6 0.0 8.4e-42 143.2 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CRG89822.1 - 9.6e-10 38.7 0.0 1.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Fungal_trans PF04082.18 CRG89823.1 - 6.4e-24 84.4 0.0 1e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89823.1 - 3.7e-07 30.1 11.4 6.4e-07 29.4 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 CRG89824.1 - 4.9e-71 239.2 0.0 6.9e-71 238.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89824.1 - 6.5e-53 179.7 0.0 9.8e-53 179.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG89824.1 - 0.0005 19.0 0.0 0.0005 19.0 0.0 2.2 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 CRG89824.1 - 0.0042 16.5 0.0 0.068 12.5 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Thioredoxin_7 PF13899.6 CRG89825.1 - 1.8e-16 60.0 0.0 4e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 CRG89825.1 - 3.1e-14 52.5 0.8 6.1e-14 51.6 0.8 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 CRG89825.1 - 3.9e-08 33.4 0.0 1.2e-07 31.8 0.0 1.8 2 0 0 2 2 2 1 UBX domain Thioredoxin_2 PF13098.6 CRG89825.1 - 0.054 13.9 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain TAP_C PF03943.13 CRG89825.1 - 0.069 12.8 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 TAP C-terminal domain AAA_16 PF13191.6 CRG89826.1 - 3.6e-12 47.0 2.1 5.2e-11 43.2 0.3 3.0 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 CRG89826.1 - 2.1e-11 44.4 0.0 8.9e-11 42.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG89826.1 - 1.3e-10 41.6 0.0 3.1e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain Cdc6_C PF09079.11 CRG89826.1 - 2.9e-07 30.3 0.2 3.2e-06 27.0 0.0 2.7 2 1 0 2 2 2 1 CDC6, C terminal winged helix domain NACHT PF05729.12 CRG89826.1 - 4.4e-06 26.7 0.0 8.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_lid_10 PF17872.1 CRG89826.1 - 0.00013 22.0 0.1 0.00028 20.9 0.1 1.5 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 CRG89826.1 - 0.0013 19.1 0.0 0.0029 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CRG89826.1 - 0.002 17.6 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein NB-ARC PF00931.22 CRG89826.1 - 0.011 14.9 0.0 0.02 14.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 CRG89826.1 - 0.017 15.5 0.0 0.036 14.4 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 CRG89826.1 - 0.026 14.1 0.0 0.047 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TTc_toxin_rep PF18807.1 CRG89826.1 - 0.032 14.0 0.1 0.1 12.5 0.1 1.8 1 0 0 1 1 1 0 Tripartite Tc toxins repeat NTPase_1 PF03266.15 CRG89826.1 - 0.039 13.9 0.0 0.077 12.9 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.6 CRG89826.1 - 0.057 13.5 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 CRG89826.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 CRG89826.1 - 0.07 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CRG89826.1 - 0.096 12.8 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 CRG89826.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AFG1_ATPase PF03969.16 CRG89826.1 - 0.12 11.2 0.0 0.2 10.5 0.0 1.3 1 0 0 1 1 1 0 AFG1-like ATPase AAA_5 PF07728.14 CRG89826.1 - 0.13 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TIP49 PF06068.13 CRG89826.1 - 0.15 11.3 0.0 0.32 10.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Amidohydro_2 PF04909.14 CRG89827.1 - 2.5e-19 70.2 0.6 1.7e-17 64.1 0.0 2.2 2 1 0 2 2 2 2 Amidohydrolase DUF4752 PF15944.5 CRG89828.1 - 0.05 13.6 0.3 0.11 12.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) ADH_zinc_N PF00107.26 CRG89829.1 - 2.2e-25 89.2 1.7 3.7e-25 88.4 1.7 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG89829.1 - 5.2e-24 84.2 0.6 9.7e-24 83.4 0.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CRG89829.1 - 4.9e-06 27.6 0.3 1.1e-05 26.5 0.3 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CRG89829.1 - 0.002 18.0 0.0 0.0072 16.2 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase NAD_binding_10 PF13460.6 CRG89829.1 - 0.0027 17.6 0.5 0.17 11.7 0.3 2.3 2 0 0 2 2 2 1 NAD(P)H-binding AlaDh_PNT_C PF01262.21 CRG89829.1 - 0.013 14.8 1.6 0.02 14.2 1.6 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain EutK_C PF16365.5 CRG89830.1 - 0.0063 16.5 0.2 6.3 6.9 0.0 4.2 4 0 0 4 4 4 2 Ethanolamine utilization protein EutK C-terminus zf-H2C2_2 PF13465.6 CRG89833.1 - 4.1e-11 42.8 15.9 2.3e-05 24.6 1.2 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 CRG89833.1 - 1.5e-07 31.4 23.4 0.042 14.3 8.2 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG89833.1 - 5.1e-06 26.9 20.9 0.11 13.4 6.7 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 CRG89833.1 - 0.025 14.6 0.1 0.025 14.6 0.1 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger Rad50_zn_hook PF04423.14 CRG89833.1 - 0.042 13.7 0.4 0.088 12.7 0.4 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-Di19 PF05605.12 CRG89833.1 - 0.064 13.6 5.9 0.15 12.4 5.9 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding FYVE PF01363.21 CRG89833.1 - 0.11 12.6 6.3 0.2 11.8 0.6 2.3 2 0 0 2 2 2 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 CRG89833.1 - 0.16 12.1 8.5 0.12 12.5 2.3 2.5 1 1 2 3 3 3 0 Zinc ribbon domain HMMR_C PF15908.5 CRG89833.1 - 0.21 11.9 0.0 0.35 11.1 0.0 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal zf-C2HC_2 PF13913.6 CRG89833.1 - 0.6 10.1 5.8 0.14 12.1 0.7 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_jaz PF12171.8 CRG89833.1 - 0.8 10.1 8.1 4.9 7.6 2.3 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_9 PF16293.5 CRG89833.1 - 0.89 9.4 3.0 2 8.3 0.7 2.5 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) GAGA PF09237.11 CRG89833.1 - 1.1 9.1 7.9 2.8 7.8 1.7 2.7 1 1 1 2 2 2 0 GAGA factor DZR PF12773.7 CRG89833.1 - 2.2 8.4 7.1 7.7 6.6 6.6 2.0 1 1 1 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 CRG89833.1 - 4.7 7.3 5.8 21 5.2 5.7 2.0 1 1 0 1 1 1 0 zinc-ribbons DUF3074 PF11274.8 CRG89834.1 - 2.4e-46 158.0 0.7 4e-46 157.3 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) Stk19 PF10494.9 CRG89835.1 - 5.3e-90 301.4 0.0 6.4e-90 301.1 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 DUF664 PF04978.12 CRG89835.1 - 0.039 14.4 0.0 0.074 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF664) Glyco_transf_20 PF00982.21 CRG89836.1 - 1.2e-164 548.5 0.0 1.8e-164 547.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 4HBT_3 PF13622.6 CRG89836.1 - 2.6e-46 158.9 2.2 6.3e-46 157.6 2.2 1.7 1 0 0 1 1 1 1 Thioesterase-like superfamily Trehalose_PPase PF02358.16 CRG89836.1 - 4.3e-40 137.3 0.0 7.1e-40 136.6 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 CRG89836.1 - 0.028 14.1 0.2 0.051 13.3 0.2 1.3 1 0 0 1 1 1 0 Starch synthase catalytic domain FSA_C PF10479.9 CRG89837.1 - 5.4 5.0 10.8 6.6 4.7 10.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RAP1 PF07218.11 CRG89837.1 - 8.1 4.6 12.4 10 4.3 12.4 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PCI PF01399.27 CRG89838.1 - 1.6e-10 41.4 0.0 5.2e-10 39.8 0.0 1.9 1 0 0 1 1 1 1 PCI domain eIF3m_C_helix PF18005.1 CRG89838.1 - 4.3e-10 39.1 3.1 1.1e-09 37.8 3.1 1.8 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix Gp-FAR-1 PF05823.12 CRG89838.1 - 0.087 13.2 0.1 0.37 11.1 0.1 2.1 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) K_channel_TID PF07941.11 CRG89838.1 - 4.1 7.9 7.6 0.59 10.6 3.0 1.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain ADK PF00406.22 CRG89839.1 - 4.7e-42 143.6 0.0 8.2e-42 142.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 CRG89839.1 - 4.5e-33 114.5 0.0 7.2e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG89839.1 - 2.6e-09 37.7 0.0 3.9e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 CRG89839.1 - 2.8e-06 27.5 0.0 1.4e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CRG89839.1 - 4.4e-06 26.5 0.1 0.042 13.5 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase SR-25 PF10500.9 CRG89839.1 - 8.2 6.0 10.0 15 5.1 10.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MARVEL PF01284.23 CRG89840.1 - 5 7.1 10.0 0.37 10.8 3.2 2.0 1 1 0 2 2 2 0 Membrane-associating domain Cnd2 PF05786.14 CRG89841.1 - 0 1054.9 0.1 0 1054.7 0.1 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 CRG89841.1 - 0.0022 18.2 0.0 0.0063 16.7 0.0 1.7 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Na_Ca_ex PF01699.24 CRG89842.1 - 2.7e-51 173.5 39.8 2.6e-26 92.4 17.6 2.6 2 0 0 2 2 2 2 Sodium/calcium exchanger protein ATF7IP_BD PF16788.5 CRG89842.1 - 2.7 8.0 4.2 5.9 6.9 4.2 1.5 1 0 0 1 1 1 0 ATF-interacting protein binding domain EF-hand_4 PF12763.7 CRG89843.1 - 4.2e-27 94.1 0.0 5.9e-13 48.7 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 CRG89843.1 - 3.5e-10 39.4 0.5 1.1e-09 37.8 0.5 1.9 1 0 0 1 1 1 1 WH2 motif EF-hand_7 PF13499.6 CRG89843.1 - 3.4e-06 27.4 0.6 0.0005 20.5 0.0 3.2 3 0 0 3 3 3 1 EF-hand domain pair DUF1720 PF08226.11 CRG89843.1 - 0.0004 20.7 50.8 0.0007 20.0 25.4 8.3 6 2 2 8 8 8 3 Domain of unknown function (DUF1720) EF-hand_1 PF00036.32 CRG89843.1 - 0.0092 15.5 0.0 0.25 11.0 0.0 2.5 2 0 0 2 2 2 1 EF hand RNA_pol_L_2 PF13656.6 CRG89844.1 - 1.6e-26 91.9 0.0 2e-26 91.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 CRG89844.1 - 4.8e-10 38.7 0.0 6.6e-10 38.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LRR_4 PF12799.7 CRG89846.1 - 0.00048 20.5 13.4 2.1 8.9 0.3 6.5 6 2 1 7 7 7 3 Leucine Rich repeats (2 copies) DUF4604 PF15377.6 CRG89846.1 - 0.054 13.9 12.0 0.086 13.3 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) LRR_6 PF13516.6 CRG89846.1 - 0.063 13.4 12.6 14 6.0 0.0 6.7 8 0 0 8 8 8 0 Leucine Rich repeat FYVE PF01363.21 CRG89846.1 - 0.082 13.1 0.2 0.31 11.2 0.2 1.9 1 0 0 1 1 1 0 FYVE zinc finger SNF2_N PF00176.23 CRG89847.1 - 1.3e-51 175.4 2.9 2.1e-50 171.4 0.6 3.0 2 1 1 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG89847.1 - 4e-17 62.6 1.0 4.5e-16 59.2 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 CRG89847.1 - 1.9e-05 24.4 8.6 1.9e-05 24.4 8.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG89847.1 - 0.0012 18.8 5.7 0.0012 18.8 5.7 2.0 2 0 0 2 2 2 1 RING-type zinc-finger AAA_34 PF13872.6 CRG89847.1 - 0.0014 17.6 0.0 0.0042 16.0 0.0 1.8 2 0 0 2 2 2 1 P-loop containing NTP hydrolase pore-1 zf-RING_2 PF13639.6 CRG89847.1 - 0.0045 17.3 9.9 0.0045 17.3 9.9 2.7 2 0 0 2 2 2 1 Ring finger domain Zn_Tnp_IS91 PF14319.6 CRG89847.1 - 2.8 8.0 15.5 0.14 12.2 3.0 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain C2 PF00168.30 CRG89848.1 - 4.7e-12 46.1 0.0 8.8e-12 45.2 0.0 1.4 1 0 0 1 1 1 1 C2 domain ArfGap PF01412.18 CRG89849.1 - 2.1e-34 118.1 0.1 2.1e-34 118.1 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 CRG89849.1 - 2.6e-22 79.7 10.7 4.3e-22 79.0 10.7 1.3 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 CRG89849.1 - 4.7e-11 43.1 1.0 1.2e-10 41.9 0.1 2.1 2 0 0 2 2 2 1 PH domain Linker_histone PF00538.19 CRG89849.1 - 0.12 12.7 0.6 4.9 7.6 0.2 3.2 3 0 0 3 3 3 0 linker histone H1 and H5 family YTH PF04146.15 CRG89850.1 - 1.7e-60 203.7 0.0 3.2e-60 202.8 0.0 1.5 1 0 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 CRG89850.1 - 1.4e-08 34.4 0.0 2.4e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG89850.1 - 0.0077 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nup_retrotrp_bd PF10599.9 CRG89850.1 - 5.8 7.6 7.3 51 4.6 0.0 4.0 3 1 0 3 3 3 0 Retro-transposon transporting motif TPR_10 PF13374.6 CRG89852.1 - 1.5e-06 27.9 0.2 5e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89852.1 - 1.3e-05 25.4 0.0 2.9e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG89852.1 - 1.7e-05 24.4 0.8 4.6e-05 23.1 0.1 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89852.1 - 0.00053 19.9 1.0 0.0019 18.2 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 CRG89852.1 - 0.00076 19.3 0.0 0.0021 18.0 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 CRG89852.1 - 0.026 14.7 0.4 0.077 13.3 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG89852.1 - 0.083 13.6 0.9 0.2 12.4 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 CRG89852.1 - 0.094 13.1 0.0 0.69 10.4 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG89852.1 - 0.14 13.1 0.1 0.53 11.2 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat PI3_PI4_kinase PF00454.27 CRG89853.1 - 5.4e-39 134.5 0.0 1e-36 127.0 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 CRG89853.1 - 9.3e-23 80.6 0.3 2e-22 79.5 0.3 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 CRG89853.1 - 0.13 11.6 0.0 0.35 10.2 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4135) Pkinase PF00069.25 CRG89854.1 - 1e-77 261.1 0.0 1.4e-77 260.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89854.1 - 6.1e-39 133.8 0.0 8.3e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CRG89854.1 - 2e-16 60.1 0.1 4.5e-16 59.0 0.1 1.6 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 CRG89854.1 - 5.2e-11 42.4 0.0 4.5e-08 32.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 CRG89854.1 - 3.4e-07 29.4 0.1 9.5e-07 27.9 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 CRG89854.1 - 3e-06 27.4 0.0 7.3e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FTA2 PF13095.6 CRG89854.1 - 0.00042 20.0 0.1 0.64 9.6 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 CRG89854.1 - 0.0024 17.8 0.1 0.01 15.8 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 CRG89854.1 - 0.013 14.9 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2961 PF11175.8 CRG89854.1 - 0.071 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2961) p450 PF00067.22 CRG89855.1 - 5.3e-79 266.1 0.0 6.8e-79 265.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 IGR PF09597.10 CRG89856.1 - 6.6e-25 87.0 0.2 1.3e-24 86.0 0.2 1.5 1 0 0 1 1 1 1 IGR protein motif SAM_1 PF00536.30 CRG89856.1 - 0.18 12.3 0.0 0.37 11.3 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pkinase PF00069.25 CRG89857.1 - 7.6e-62 209.1 0.0 9.8e-62 208.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89857.1 - 9.3e-34 116.9 0.0 1.3e-33 116.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG89857.1 - 0.0022 17.3 0.0 0.0037 16.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kinesin PF00225.23 CRG89858.1 - 1.6e-97 326.5 0.1 4e-97 325.1 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 CRG89858.1 - 2.6e-23 82.6 0.0 3.7e-22 78.9 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding PKcGMP_CC PF16808.5 CRG89858.1 - 0.24 11.3 6.2 0.17 11.8 0.7 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DAGAT PF03982.13 CRG89860.1 - 1.3e-91 306.7 0.0 1.6e-91 306.3 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.13 CRG89860.1 - 0.0078 16.0 0.1 0.013 15.2 0.1 1.3 1 0 0 1 1 1 1 Rer1 family G-patch PF01585.23 CRG89861.1 - 5.6e-06 26.2 0.0 6.2e-05 22.8 0.0 2.4 1 1 0 1 1 1 1 G-patch domain DUF936 PF06075.12 CRG89861.1 - 0.03 13.2 15.8 0.038 12.9 15.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) GREB1 PF15782.5 CRG89861.1 - 0.49 7.4 10.0 0.56 7.3 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SAPS PF04499.15 CRG89861.1 - 0.64 8.7 18.0 0.84 8.4 18.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein G-patch_2 PF12656.7 CRG89861.1 - 2.8 8.1 0.0 2.8 8.1 0.0 3.0 4 0 0 4 4 4 0 G-patch domain Syja_N PF02383.18 CRG89862.1 - 1.6e-72 244.5 0.0 2.1e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 CRG89862.1 - 1.3e-12 47.8 0.2 4.1e-12 46.1 0.1 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family SAPS PF04499.15 CRG89863.1 - 7.4 5.2 9.6 11 4.6 9.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TPR_14 PF13428.6 CRG89864.1 - 9.4e-10 38.5 4.9 3.6e-06 27.3 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 CRG89864.1 - 7.3e-07 29.1 0.3 0.067 13.6 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 CRG89864.1 - 5.4e-05 23.6 3.2 0.034 14.6 0.6 3.6 1 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89864.1 - 0.00019 21.3 0.2 3.7 7.9 0.0 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 CRG89864.1 - 0.00069 19.3 0.1 2.4 8.1 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat BTAD PF03704.17 CRG89864.1 - 0.005 17.3 0.3 0.0088 16.5 0.3 1.5 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_8 PF13181.6 CRG89864.1 - 0.0083 16.3 0.1 8.1 6.9 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 CRG89864.1 - 0.024 14.3 0.1 3 7.6 0.0 3.4 4 1 0 4 4 4 0 TPR repeat Wzy_C_2 PF11846.8 CRG89864.1 - 0.039 13.9 0.0 0.17 11.8 0.0 2.0 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Pyridoxal_deC PF00282.19 CRG89864.1 - 0.052 12.3 0.0 0.15 10.8 0.0 1.7 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase conserved domain TPR_16 PF13432.6 CRG89864.1 - 0.079 13.6 1.3 0.44 11.2 0.4 2.6 2 2 1 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89864.1 - 0.082 13.2 2.9 4 7.8 0.8 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat ChAPs PF09295.10 CRG89864.1 - 0.11 11.5 0.5 0.28 10.2 0.1 1.8 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) Adaptin_N PF01602.20 CRG89865.1 - 7.8e-72 242.5 8.2 4.5e-67 226.8 7.7 2.0 2 0 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 CRG89865.1 - 3.4e-10 40.2 1.2 6.1e-07 29.6 0.0 2.4 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 CRG89865.1 - 0.0039 17.3 0.9 23 5.6 0.1 4.4 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 CRG89865.1 - 0.0048 17.3 0.9 3.1 8.2 0.0 3.1 2 1 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 CRG89865.1 - 0.029 14.9 6.1 0.95 10.0 0.1 4.3 4 1 1 5 5 5 0 HEAT-like repeat Cu-oxidase_3 PF07732.15 CRG89866.1 - 1.4e-37 128.3 1.2 3.1e-37 127.2 1.2 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG89866.1 - 2.8e-28 98.4 9.0 4.6e-25 88.0 0.7 3.5 3 2 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 CRG89866.1 - 1.1e-09 38.7 0.0 2.8e-08 34.1 0.0 2.9 2 1 0 2 2 2 1 Multicopper oxidase MFS_1 PF07690.16 CRG89867.1 - 4.7e-43 147.5 39.2 4.7e-43 147.5 39.2 1.8 1 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CRG89867.1 - 3.2 5.9 19.6 0.073 11.3 0.2 3.6 4 0 0 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family adh_short PF00106.25 CRG89869.1 - 2.1e-07 30.6 0.0 2.7e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89869.1 - 3.6e-07 30.0 0.0 4.1e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CRG89869.1 - 0.0033 17.4 0.0 0.0044 16.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 CRG89869.1 - 0.054 14.1 0.0 0.094 13.3 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 CRG89869.1 - 0.08 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family AflR PF08493.10 CRG89870.1 - 2.2e-11 43.8 13.2 4.4e-11 42.8 13.2 1.7 1 1 0 1 1 1 1 Aflatoxin regulatory protein Zn_clus PF00172.18 CRG89870.1 - 2.6e-08 33.8 10.9 6.1e-08 32.7 10.9 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 CRG89870.1 - 0.29 11.5 10.9 0.29 11.5 1.6 3.4 3 0 0 3 3 3 0 Opy2 protein Anti-TRAP PF15777.5 CRG89870.1 - 0.64 10.0 0.0 0.64 10.0 0.0 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein SnoaL_2 PF12680.7 CRG89871.1 - 0.0002 21.9 0.0 0.00042 20.9 0.0 1.5 2 0 0 2 2 2 1 SnoaL-like domain MbeB_N PF04837.12 CRG89871.1 - 0.038 14.3 0.1 0.49 10.7 0.0 2.2 2 0 0 2 2 2 0 MbeB-like, N-term conserved region NAD_binding_10 PF13460.6 CRG89872.1 - 3.9e-13 49.7 0.0 5.2e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG89872.1 - 0.0015 18.1 0.0 0.0076 15.8 0.0 2.0 2 1 0 2 2 2 1 NmrA-like family Epimerase PF01370.21 CRG89872.1 - 0.04 13.4 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CRG89872.1 - 0.11 12.9 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 CRG89873.1 - 9.8e-55 185.6 1.1 1.4e-54 185.2 1.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89873.1 - 4.8e-48 163.2 1.1 5.6e-48 163.0 1.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89873.1 - 1.1e-12 48.2 1.4 1.5e-12 47.8 1.4 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG89873.1 - 0.061 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CRG89873.1 - 0.061 12.8 0.4 0.29 10.6 0.4 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_11 PF08241.12 CRG89873.1 - 0.22 12.2 1.4 4.5 8.0 1.4 2.6 1 1 0 1 1 1 0 Methyltransferase domain FAD_binding_3 PF01494.19 CRG89874.1 - 1e-17 64.4 0.0 1.6e-17 63.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG89874.1 - 6.9e-07 28.8 0.1 0.0056 15.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG89874.1 - 6.1e-06 26.0 5.1 0.012 15.2 0.2 3.1 2 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG89874.1 - 2.5e-05 23.5 0.2 4.2e-05 22.8 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG89874.1 - 4.4e-05 23.6 0.1 0.00022 21.4 0.1 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG89874.1 - 0.0021 16.8 0.2 0.03 13.0 0.0 2.2 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 CRG89874.1 - 0.005 15.9 0.5 0.15 11.1 0.1 2.9 3 0 0 3 3 3 1 Lycopene cyclase protein GIDA PF01134.22 CRG89874.1 - 0.0064 15.6 0.0 0.26 10.3 0.0 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CRG89874.1 - 0.0097 15.2 0.0 0.027 13.7 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG89874.1 - 0.01 15.2 0.1 0.023 14.1 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG89874.1 - 0.093 13.3 0.2 2.7 8.6 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG89874.1 - 0.12 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family MFS_1 PF07690.16 CRG89875.1 - 1.1e-40 139.7 48.3 2.7e-40 138.4 48.3 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG89876.1 - 1.9e-18 66.4 0.0 3.5e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89876.1 - 1e-09 38.3 8.7 2.2e-09 37.3 8.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PNP_UDP_1 PF01048.20 CRG89877.1 - 5.8e-12 45.4 0.7 5.4e-11 42.2 0.7 2.1 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG89877.1 - 0.00068 19.6 0.1 0.0014 18.6 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG89877.1 - 0.0081 16.6 0.0 0.021 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AgrB PF04647.15 CRG89877.1 - 0.14 11.5 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Accessory gene regulator B TPR_10 PF13374.6 CRG89878.1 - 7.1e-77 251.4 0.0 5.2e-11 42.0 0.0 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 CRG89878.1 - 2.4e-70 232.8 0.1 2.5e-13 50.1 0.0 6.5 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 CRG89878.1 - 1.8e-21 74.5 0.6 0.0012 18.7 0.0 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89878.1 - 6.4e-14 50.9 0.0 1.4 9.2 0.2 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat NB-ARC PF00931.22 CRG89878.1 - 1.4e-10 40.8 0.0 3.2e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 NB-ARC domain TPR_1 PF00515.28 CRG89878.1 - 6.7e-09 35.2 0.0 2.1 8.3 0.0 7.0 8 0 0 8 8 8 2 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 CRG89878.1 - 1.2e-08 34.5 0.1 3e-08 33.2 0.1 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily TPR_16 PF13432.6 CRG89878.1 - 7.3e-08 32.9 0.0 2.8 8.7 0.0 6.6 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG89878.1 - 5.5e-07 30.0 0.2 0.62 10.6 0.0 5.1 3 2 2 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG89878.1 - 1.2e-05 25.5 0.2 0.0066 16.7 0.2 4.6 3 2 1 4 4 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 CRG89878.1 - 2.1e-05 24.5 1.0 9.3 6.9 0.0 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat AAA_16 PF13191.6 CRG89878.1 - 4e-05 24.0 0.0 0.00045 20.7 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain TPR_4 PF07721.14 CRG89878.1 - 5.4e-05 23.4 0.4 31 5.6 0.0 6.5 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 CRG89878.1 - 0.00097 19.6 1.5 15 6.5 0.1 5.5 5 0 0 5 5 4 0 Tetratricopeptide repeat AAA_22 PF13401.6 CRG89878.1 - 0.0013 19.0 0.0 0.016 15.5 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA PF00004.29 CRG89878.1 - 0.0029 18.0 0.0 0.4 11.1 0.0 2.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TPR_8 PF13181.6 CRG89878.1 - 0.0029 17.7 0.0 25 5.4 0.0 4.9 6 0 0 6 6 5 0 Tetratricopeptide repeat NACHT PF05729.12 CRG89878.1 - 0.0042 17.0 0.3 0.017 15.0 0.0 2.3 3 0 0 3 3 2 1 NACHT domain TPR_5 PF12688.7 CRG89878.1 - 0.028 14.6 8.4 4 7.7 0.0 5.5 5 2 2 7 7 6 0 Tetratrico peptide repeat Ntox35 PF15534.6 CRG89878.1 - 0.056 13.9 0.4 1.1e+02 3.3 0.0 4.1 4 0 0 4 4 4 0 Bacterial toxin 35 RPN7 PF10602.9 CRG89878.1 - 0.065 12.9 0.0 62 3.2 0.0 3.9 2 1 2 4 4 4 0 26S proteasome subunit RPN7 DUF3050 PF11251.8 CRG89878.1 - 0.078 12.6 1.0 0.22 11.1 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3050) CbiA PF01656.23 CRG89878.1 - 0.14 12.2 0.1 0.7 10.0 0.1 2.1 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF3435 PF11917.8 CRG89879.1 - 1e-66 225.6 0.0 5.9e-39 134.2 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) RasGAP_C PF03836.15 CRG89879.1 - 0.51 10.5 4.8 0.088 13.0 0.9 1.6 2 0 0 2 2 2 0 RasGAP C-terminus BRE1 PF08647.11 CRG89879.1 - 0.74 9.9 3.0 2.4 8.3 0.8 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase Acetyltransf_10 PF13673.7 CRG89880.1 - 2.1e-06 27.7 0.0 0.00081 19.3 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG89880.1 - 3.1e-06 27.5 0.2 7.6e-05 23.1 0.2 2.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG89880.1 - 0.017 15.3 0.4 0.32 11.2 0.2 2.7 2 1 0 2 2 2 0 Acetyltransferase (GNAT) family LIN37 PF15306.6 CRG89881.1 - 1 9.6 9.3 0.89 9.8 3.5 2.4 2 0 0 2 2 2 0 LIN37 CDC45 PF02724.14 CRG89881.1 - 1.5 7.1 7.2 2.1 6.5 7.2 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 CRG89881.1 - 3.7 7.8 11.3 0.88 9.8 6.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3723 PF12520.8 CRG89882.1 - 3.9e-26 91.8 0.1 5.1e-26 91.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3723) Pkinase PF00069.25 CRG89883.1 - 1.7e-09 37.5 0.0 2.4e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG89883.1 - 5.4e-05 22.6 0.0 8e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG89883.1 - 0.014 14.4 0.0 0.022 13.7 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain TPR_12 PF13424.6 CRG89884.1 - 1e-61 205.1 6.3 8.8e-17 61.2 0.1 4.0 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 CRG89884.1 - 3.5e-55 182.5 5.5 7e-14 51.2 0.1 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 CRG89884.1 - 5.8e-27 91.7 3.3 7.1e-05 22.6 0.0 5.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 CRG89884.1 - 3.8e-19 67.2 0.1 0.0025 17.8 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 CRG89884.1 - 2.4e-17 61.9 0.2 0.0036 17.1 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 CRG89884.1 - 2.2e-15 56.9 1.0 0.00072 20.0 0.2 5.1 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 CRG89884.1 - 1.3e-13 49.9 0.9 0.12 12.6 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG89884.1 - 1.8e-11 44.0 7.9 7.8e-10 38.6 5.3 2.0 1 1 1 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 CRG89884.1 - 2.2e-10 41.0 0.0 3.4 8.4 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_5 PF12688.7 CRG89884.1 - 5.4e-09 36.3 1.2 0.0011 19.3 0.4 4.0 1 1 2 3 3 3 2 Tetratrico peptide repeat TPR_17 PF13431.6 CRG89884.1 - 1.6e-08 34.3 4.9 0.56 10.7 0.1 5.2 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG89884.1 - 2.4e-08 34.1 0.1 7 7.8 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG89884.1 - 7.1e-08 32.6 3.4 0.13 12.5 0.1 4.5 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 CRG89884.1 - 8e-07 28.9 0.1 3.8 8.0 0.0 5.2 5 0 0 5 5 5 1 PPR repeat TPR_6 PF13174.6 CRG89884.1 - 8.7e-07 29.2 3.5 1.8 9.4 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 CRG89884.1 - 1.2e-06 28.3 0.0 3.4 7.8 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_4 PF07721.14 CRG89884.1 - 2.9e-05 24.3 3.1 26 5.8 0.1 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat RPN6_N PF18055.1 CRG89884.1 - 4.2e-05 23.9 4.0 0.037 14.4 0.5 3.0 1 1 3 4 4 4 3 26S proteasome regulatory subunit RPN6 N-terminal domain PPR_1 PF12854.7 CRG89884.1 - 0.00026 20.6 1.0 55 3.6 0.0 4.9 5 0 0 5 5 5 0 PPR repeat HSCB_C PF07743.13 CRG89884.1 - 0.00029 21.3 0.9 0.37 11.3 0.2 3.7 2 1 1 3 3 3 1 HSCB C-terminal oligomerisation domain TPR_20 PF14561.6 CRG89884.1 - 0.0003 21.1 0.8 12 6.3 0.0 4.7 1 1 4 5 5 5 0 Tetratricopeptide repeat DUF4074 PF13293.6 CRG89884.1 - 0.0013 19.0 0.1 48 4.4 0.0 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4074) DUF5570 PF17731.1 CRG89884.1 - 0.0028 17.7 0.1 6.2 6.9 0.0 3.1 2 1 1 3 3 3 1 Family of unknown function (DUF5570) TPR_11 PF13414.6 CRG89884.1 - 0.0082 15.8 2.9 8.7 6.1 0.0 4.4 5 0 0 5 5 5 0 TPR repeat RBD-FIP PF09457.10 CRG89884.1 - 0.016 15.1 1.6 13 5.8 0.0 3.3 3 0 0 3 3 3 0 FIP domain Spore_YpjB PF09577.10 CRG89884.1 - 0.11 12.3 2.1 2 8.2 0.1 3.0 1 1 3 4 4 4 0 Sporulation protein YpjB (SpoYpjB) DUF1897 PF09005.10 CRG89884.1 - 0.13 11.7 0.1 51 3.5 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1897) AAA_16 PF13191.6 CRG89885.1 - 5.8e-07 30.0 0.3 3.1e-06 27.7 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 CRG89885.1 - 0.00016 21.0 0.4 0.24 10.6 0.0 2.2 1 1 0 2 2 2 2 NB-ARC domain ATPase_2 PF01637.18 CRG89885.1 - 0.00083 19.3 0.0 0.0017 18.3 0.0 1.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 CRG89885.1 - 0.0032 17.4 0.1 0.64 9.9 0.0 2.3 1 1 1 2 2 2 1 NACHT domain AAA_14 PF13173.6 CRG89885.1 - 0.017 15.2 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 CRG89885.1 - 0.021 14.5 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 CRG89885.1 - 0.026 15.1 0.0 0.05 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain ParA PF10609.9 CRG89885.1 - 0.039 13.4 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase TrwB_AAD_bind PF10412.9 CRG89885.1 - 0.041 12.8 0.0 0.074 12.0 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.29 CRG89885.1 - 0.072 13.5 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 CRG89885.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 CRG89885.1 - 0.14 12.1 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) F-box PF00646.33 CRG89890.1 - 5e-06 26.2 0.1 1.9e-05 24.4 0.1 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG89890.1 - 0.031 14.2 0.2 0.12 12.3 0.1 2.0 2 0 0 2 2 2 0 F-box-like DUF3725 PF12523.8 CRG89890.1 - 0.17 12.2 0.0 0.38 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3725) SH3_9 PF14604.6 CRG89891.1 - 1.3e-27 95.4 4.1 3.6e-14 52.3 0.3 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 CRG89891.1 - 4.5e-26 90.2 4.1 1.6e-13 50.0 0.4 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 CRG89891.1 - 6.1e-17 61.0 0.1 2.1e-08 33.7 0.1 2.6 2 0 0 2 2 2 2 Variant SH3 domain Cofilin_ADF PF00241.20 CRG89891.1 - 1.1e-16 60.7 0.0 2.7e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dynamin_M PF01031.20 CRG89892.1 - 1.2e-109 366.0 0.0 2.3e-109 365.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CRG89892.1 - 5.5e-56 189.2 1.1 7.6e-56 188.8 0.0 1.8 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 CRG89892.1 - 2.9e-31 107.5 0.4 2.9e-31 107.5 0.4 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 CRG89892.1 - 0.00024 21.2 0.4 0.0019 18.2 0.4 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase UAA PF08449.11 CRG89893.1 - 4.6e-82 275.6 17.1 7.6e-60 202.7 2.4 2.0 1 1 1 2 2 2 2 UAA transporter family Nuc_sug_transp PF04142.15 CRG89893.1 - 0.00013 21.2 0.3 0.00013 21.2 0.3 2.1 3 0 0 3 3 3 1 Nucleotide-sugar transporter EamA PF00892.20 CRG89893.1 - 0.53 10.5 43.3 0.11 12.7 13.5 3.8 2 2 2 4 4 4 0 EamA-like transporter family Rad17 PF03215.15 CRG89894.1 - 9.1e-31 107.2 0.0 1.9e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 CRG89894.1 - 3.6e-05 24.2 0.4 8.3e-05 23.0 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 CRG89894.1 - 3.8e-05 24.0 0.0 8.8e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CRG89894.1 - 0.00032 21.1 0.0 0.00076 19.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 CRG89894.1 - 0.00067 18.8 0.0 0.0013 17.8 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 CRG89894.1 - 0.0086 15.8 0.2 0.017 14.8 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CRG89894.1 - 0.01 15.8 0.0 0.028 14.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 CRG89894.1 - 0.017 14.9 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 CRG89894.1 - 0.049 13.5 0.0 0.089 12.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_19 PF13245.6 CRG89894.1 - 0.066 13.6 0.1 0.18 12.2 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CRG89894.1 - 0.071 13.4 0.1 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 CRG89894.1 - 0.077 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CRG89894.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CRG89894.1 - 0.13 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 CRG89894.1 - 0.15 11.7 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 CRG89894.1 - 0.15 11.9 0.0 0.55 10.0 0.0 1.9 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_11 PF13086.6 CRG89894.1 - 0.15 11.9 2.7 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG89894.1 - 0.19 12.1 0.0 0.38 11.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_6 PF12774.7 CRG89894.1 - 0.23 10.4 0.0 0.38 9.7 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_21 PF13304.6 CRG89894.1 - 0.89 9.3 5.8 3 7.6 0.1 2.9 2 2 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CRG89894.1 - 1.1 9.4 4.8 0.26 11.5 0.2 2.3 3 0 0 3 3 3 0 AAA domain ELMO_CED12 PF04727.13 CRG89895.1 - 1e-50 172.3 0.2 2e-50 171.4 0.2 1.5 1 0 0 1 1 1 1 ELMO/CED-12 family PH_12 PF16457.5 CRG89895.1 - 6.2e-36 123.9 0.0 1.2e-35 122.9 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 CRG89895.1 - 1.9e-14 53.9 0.0 4.5e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) DUF1752 PF08550.10 CRG89896.1 - 3.4e-10 39.6 6.6 6.9e-10 38.6 6.6 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) SUI1 PF01253.22 CRG89898.1 - 8e-24 84.0 0.1 1.8e-23 82.9 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF812 PF05667.11 CRG89899.1 - 0.02 13.8 1.9 0.029 13.3 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF812) TMEM117 PF15113.6 CRG89899.1 - 0.022 13.7 0.1 0.032 13.2 0.1 1.1 1 0 0 1 1 1 0 TMEM117 protein family Baculo_PEP_C PF04513.12 CRG89899.1 - 0.07 13.2 0.0 0.35 10.9 0.0 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ZapB PF06005.12 CRG89899.1 - 0.09 13.2 1.5 0.85 10.1 0.5 2.6 2 0 0 2 2 2 0 Cell division protein ZapB Snapin_Pallidin PF14712.6 CRG89899.1 - 0.16 12.4 0.4 0.33 11.4 0.1 1.7 2 0 0 2 2 2 0 Snapin/Pallidin DUF4512 PF14975.6 CRG89899.1 - 0.24 12.2 0.3 0.78 10.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Cgr1 PF03879.14 CRG89900.1 - 8.8e-34 116.1 27.7 9.8e-34 116.0 27.7 1.0 1 0 0 1 1 1 1 Cgr1 family STAT_bind PF02864.15 CRG89900.1 - 0.14 12.7 4.2 0.17 12.4 4.2 1.1 1 0 0 1 1 1 0 STAT protein, DNA binding domain Mito_carr PF00153.27 CRG89901.1 - 4.8e-65 215.5 1.0 2.6e-21 75.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 CRG89901.1 - 0.0043 16.2 0.2 3.6 6.7 0.0 3.2 2 2 1 3 3 3 2 Gammaproteobacterial serine protease dCMP_cyt_deam_1 PF00383.23 CRG89902.1 - 5.1e-14 52.0 0.2 6.4e-14 51.7 0.2 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 CRG89902.1 - 7.1e-10 39.2 2.6 9.5e-07 29.1 0.7 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 CRG89902.1 - 0.00025 20.7 0.4 0.34 10.5 0.0 2.1 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases SUa-2TM PF18179.1 CRG89903.1 - 4.2 6.6 5.8 2.6 7.2 3.0 1.9 1 1 1 2 2 2 0 SMODS- and Ubiquitin system-associated 2TM effector domain MFS_1 PF07690.16 CRG89904.1 - 6.5e-42 143.7 46.9 6.5e-42 143.7 46.9 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG89904.1 - 4.7e-12 45.1 14.2 4.7e-12 45.1 14.2 2.1 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) p450 PF00067.22 CRG89905.1 - 1.3e-26 93.4 0.1 2e-26 92.7 0.1 1.4 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CRG89906.1 - 7.4e-44 150.2 0.0 9.9e-44 149.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sortilin-Vps10 PF15902.5 CRG89907.1 - 2e-287 953.0 4.2 4.7e-145 483.8 1.5 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 CRG89907.1 - 1.5e-93 311.8 16.7 1.6e-47 162.0 7.4 2.4 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 CRG89907.1 - 2e-13 48.1 20.0 0.16 12.0 0.2 10.1 9 0 0 9 9 9 5 BNR/Asp-box repeat CHB_HEX_C PF03174.13 CRG89907.1 - 0.0083 16.1 0.2 2.7 8.0 0.0 4.4 4 1 1 5 5 5 1 Chitobiase/beta-hexosaminidase C-terminal domain Mo-co_dimer PF03404.16 CRG89907.1 - 0.021 14.8 3.9 9.4 6.2 0.0 4.9 5 1 0 5 5 5 0 Mo-co oxidoreductase dimerisation domain Sec10 PF07393.11 CRG89910.1 - 6.3e-229 762.1 0.0 8.8e-229 761.6 0.0 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec10 Fructosamin_kin PF03881.14 CRG89910.1 - 0.095 11.9 0.0 0.2 10.8 0.0 1.4 1 0 0 1 1 1 0 Fructosamine kinase A_deaminase PF00962.22 CRG89911.1 - 2.8e-124 414.7 0.0 4e-124 414.2 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase DHquinase_I PF01487.15 CRG89913.1 - 1.8e-30 106.9 0.0 3e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 CRG89913.1 - 2.7e-18 66.6 0.1 5e-18 65.7 0.1 1.4 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 CRG89913.1 - 2e-13 50.4 0.0 4.5e-13 49.3 0.0 1.7 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 CRG89913.1 - 7.5e-09 35.8 0.1 3.4e-08 33.6 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase SDH_C PF18317.1 CRG89913.1 - 1e-06 28.4 0.8 1.9e-06 27.5 0.8 1.5 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain F420_oxidored PF03807.17 CRG89913.1 - 0.031 14.9 0.1 0.1 13.2 0.1 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent EcoEI_R_C PF08463.10 CRG89913.1 - 0.085 13.0 0.1 15 5.7 0.0 2.8 3 0 0 3 3 3 0 EcoEI R protein C-terminal Fungal_trans PF04082.18 CRG89914.1 - 2.3e-19 69.5 1.1 3.8e-19 68.8 1.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89914.1 - 1.8e-07 31.1 13.8 3e-07 30.4 13.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG89915.1 - 5.6e-20 71.6 48.6 2.8e-18 66.0 28.8 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG89915.1 - 4.6e-06 25.2 16.9 0.0064 14.8 1.1 3.1 2 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family Collectrin PF16959.5 CRG89915.1 - 0.89 9.3 3.8 1.4 8.7 0.1 2.3 2 0 0 2 2 2 0 Renal amino acid transporter Methyltransf_2 PF00891.18 CRG89916.1 - 1.3e-08 34.5 0.0 2e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain LppA PF16708.5 CRG89917.1 - 0.093 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipoprotein confined to pathogenic Mycobacterium AAA_12 PF13087.6 CRG89918.1 - 1.1e-39 136.2 0.0 3.7e-39 134.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CRG89918.1 - 1.5e-28 100.3 0.0 1.2e-16 61.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 CRG89918.1 - 5.5e-10 39.4 0.0 0.0094 15.7 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 CRG89918.1 - 7e-08 32.4 0.0 4.6e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CRG89918.1 - 1.3e-05 25.5 0.0 3.2e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 CRG89918.1 - 0.0014 18.4 0.1 0.0037 17.0 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein UvrD_C_2 PF13538.6 CRG89918.1 - 0.0083 15.9 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 CRG89918.1 - 0.011 15.7 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 Helicase DUF2075 PF09848.9 CRG89918.1 - 0.023 13.9 0.1 0.073 12.3 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TetR_C_11 PF16859.5 CRG89918.1 - 0.027 14.8 0.0 10 6.5 0.0 2.9 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Hydantoinase_B PF02538.14 CRG89919.1 - 4.1e-27 94.8 1.1 5.5e-27 94.4 1.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase AAA_16 PF13191.6 CRG89919.1 - 0.004 17.5 0.0 0.012 16.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CRG89919.1 - 0.03 14.6 0.4 0.77 10.0 0.1 3.1 3 1 0 3 3 3 0 AAA domain AAA_14 PF13173.6 CRG89919.1 - 0.11 12.5 0.0 3.6 7.6 0.0 3.3 4 0 0 4 4 4 0 AAA domain API5 PF05918.11 CRG89919.1 - 0.13 11.0 0.1 0.21 10.3 0.1 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) adh_short PF00106.25 CRG89920.1 - 3.8e-20 72.2 0.7 3.5e-18 65.8 0.5 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89920.1 - 6.4e-12 45.5 0.9 4e-10 39.7 0.8 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89920.1 - 4.8e-10 39.6 0.3 6.7e-10 39.2 0.3 1.3 1 0 0 1 1 1 1 KR domain PPARgamma_N PF12577.8 CRG89920.1 - 0.019 15.6 0.1 0.037 14.7 0.1 1.4 1 0 0 1 1 1 0 PPAR gamma N-terminal region Ribosomal_L12 PF00542.19 CRG89920.1 - 0.12 12.7 0.5 0.45 10.9 0.5 1.9 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain Fungal_trans_2 PF11951.8 CRG89921.1 - 6.7e-09 35.0 1.6 1.7e-08 33.7 1.6 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain GFO_IDH_MocA_C PF02894.17 CRG89922.1 - 1.2e-05 25.2 0.0 2.4e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain UNC-93 PF05978.16 CRG89923.1 - 2.8e-15 56.4 6.9 8e-15 54.9 6.9 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CRG89923.1 - 1.6e-10 40.4 32.4 1.6e-10 40.4 32.4 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4231 PF14015.6 CRG89923.1 - 0.014 15.9 0.1 0.06 13.8 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Phage_holin_7_1 PF16081.5 CRG89923.1 - 0.027 14.7 0.0 0.074 13.2 0.0 1.7 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family DUF4131 PF13567.6 CRG89923.1 - 0.84 9.3 0.0 0.84 9.3 0.0 3.9 3 2 1 4 4 4 0 Domain of unknown function (DUF4131) Fungal_trans PF04082.18 CRG89925.1 - 9.8e-30 103.5 1.0 2.3e-29 102.3 1.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89925.1 - 5.5e-06 26.4 10.6 1.3e-05 25.2 10.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4185 PF13810.6 CRG89926.1 - 2.1e-07 30.5 3.8 3.9e-07 29.6 3.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) Fungal_trans PF04082.18 CRG89927.1 - 8.3e-12 44.7 0.0 1.3e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain bZIP_2 PF07716.15 CRG89928.1 - 2.5e-07 30.7 5.4 3.9e-07 30.1 5.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 CRG89928.1 - 3.9e-06 26.9 7.2 6.6e-06 26.1 7.2 1.3 1 0 0 1 1 1 1 bZIP transcription factor Takusan PF04822.13 CRG89928.1 - 0.032 14.1 1.6 0.066 13.1 1.6 1.5 1 0 0 1 1 1 0 Takusan bZIP_Maf PF03131.17 CRG89928.1 - 0.36 11.4 8.1 0.064 13.8 4.0 1.9 2 0 0 2 2 2 0 bZIP Maf transcription factor CCDC106 PF15794.5 CRG89928.1 - 2.8 7.6 12.6 0.95 9.1 2.7 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 p450 PF00067.22 CRG89931.1 - 5.9e-66 223.1 0.0 7.4e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 OprB PF04966.12 CRG89931.1 - 0.13 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate-selective porin, OprB family Glyco_trans_2_3 PF13632.6 CRG89932.1 - 8.2e-36 123.8 1.2 1.7e-35 122.7 1.2 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 CMAS PF02353.20 CRG89933.1 - 2.7e-57 194.2 0.6 3.2e-57 193.9 0.6 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 CRG89933.1 - 4.8e-09 36.3 0.0 8.7e-09 35.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG89933.1 - 7e-08 33.0 0.0 1.6e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG89933.1 - 1.9e-07 31.7 0.0 4.1e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 CRG89933.1 - 0.00026 20.6 0.0 0.00042 19.9 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 CRG89933.1 - 0.00081 19.0 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 CRG89933.1 - 0.0032 17.2 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 CRG89933.1 - 0.011 16.4 0.0 0.02 15.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CRG89933.1 - 0.022 14.5 0.0 0.036 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 CRG89933.1 - 0.038 14.0 0.0 0.082 12.9 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 CRG89933.1 - 0.14 11.5 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Beta-lactamase PF00144.24 CRG89934.1 - 6.6e-46 157.1 0.4 1.4e-45 156.0 0.4 1.5 1 1 0 1 1 1 1 Beta-lactamase Fungal_trans PF04082.18 CRG89935.1 - 4.9e-30 104.4 1.4 1.1e-29 103.3 1.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89935.1 - 9.7e-07 28.8 15.5 1.8e-06 28.0 15.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AP_endonuc_2 PF01261.24 CRG89936.1 - 4.7e-31 107.9 0.0 6.6e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel adh_short_C2 PF13561.6 CRG89937.1 - 7.1e-55 186.1 0.2 8.9e-55 185.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89937.1 - 1.8e-48 164.6 0.3 2.2e-48 164.3 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89937.1 - 9.2e-14 51.8 0.5 1.2e-13 51.4 0.5 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG89937.1 - 0.0021 17.5 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CRG89937.1 - 0.01 15.3 0.0 0.035 13.6 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family AdoHcyase_NAD PF00670.21 CRG89937.1 - 0.16 12.1 1.2 0.56 10.3 0.6 2.0 1 1 1 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Beta_helix PF13229.6 CRG89938.1 - 4.9e-12 46.0 24.6 1.8e-10 40.9 8.1 3.4 2 1 1 3 3 3 3 Right handed beta helix region Pro-kuma_activ PF09286.11 CRG89939.1 - 1.4e-37 129.1 0.2 1.5e-36 125.8 0.0 2.2 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG89939.1 - 0.00091 18.6 1.5 0.0016 17.8 0.1 2.0 2 0 0 2 2 2 1 Subtilase family DNA_primase_lrg PF04104.14 CRG89939.1 - 0.072 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Glyco_hydro_20 PF00728.22 CRG89940.1 - 3.9e-28 98.9 0.1 8.6e-28 97.7 0.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain APH PF01636.23 CRG89940.1 - 3.5e-16 59.9 0.0 1e-06 28.9 0.0 2.6 2 1 0 2 2 2 2 Phosphotransferase enzyme family Glyco_hydro_20b PF02838.15 CRG89940.1 - 4e-07 30.8 0.0 8.2e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF3638 PF12340.8 CRG89941.1 - 4.1e-92 307.6 1.0 7.2e-92 306.8 1.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3638) DUF3645 PF12359.8 CRG89941.1 - 2.9e-15 55.4 0.1 5.8e-15 54.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3645) FlgN PF05130.12 CRG89941.1 - 0.25 11.8 1.3 3 8.4 0.1 3.3 3 0 0 3 3 3 0 FlgN protein adh_short PF00106.25 CRG89942.1 - 3.7e-27 95.1 0.0 1.9e-21 76.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89942.1 - 1.1e-15 57.8 0.0 3.4e-12 46.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89942.1 - 1e-08 35.3 0.0 1.7e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG89942.1 - 0.00051 19.6 0.0 0.00074 19.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_deac_3 PF15421.6 CRG89942.1 - 0.038 12.5 0.1 0.056 11.9 0.1 1.1 1 0 0 1 1 1 0 Putative polysaccharide deacetylase Methyltransf_31 PF13847.6 CRG89943.1 - 0.13 12.0 0.2 0.3 10.8 0.2 1.6 1 0 0 1 1 1 0 Methyltransferase domain H_lectin PF09458.10 CRG89944.1 - 3.1e-21 75.3 5.3 1.1e-13 51.2 0.2 3.4 3 0 0 3 3 3 3 H-type lectin domain Astacin PF01400.24 CRG89944.1 - 5e-08 32.8 0.1 1.8e-07 31.0 0.1 1.9 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 CRG89944.1 - 2.7e-05 24.1 2.4 0.12 12.3 0.1 2.4 1 1 1 2 2 2 2 Matrixin Peptidase_M43 PF05572.13 CRG89944.1 - 0.034 14.1 0.2 0.11 12.4 0.1 1.9 1 1 1 2 2 2 0 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 CRG89944.1 - 0.037 14.2 0.2 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12 HIG_1_N PF04588.13 CRG89945.1 - 6.4e-08 32.7 0.3 6.4e-08 32.7 0.3 1.9 2 0 0 2 2 2 1 Hypoxia induced protein conserved region Claudin_2 PF13903.6 CRG89946.1 - 0.0017 18.1 2.1 0.081 12.7 0.1 2.8 2 1 1 3 3 3 2 PMP-22/EMP/MP20/Claudin tight junction Retrotrans_gag PF03732.17 CRG89947.1 - 0.021 15.1 0.4 0.021 15.1 0.4 3.2 2 2 1 3 3 3 0 Retrotransposon gag protein DUF755 PF05501.11 CRG89947.1 - 0.043 14.1 4.2 0.089 13.1 4.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Herpes_capsid PF06112.11 CRG89947.1 - 2.8 8.0 6.9 1.9 8.5 4.3 1.9 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein UbiA PF01040.18 CRG89948.1 - 2.1e-24 86.2 19.1 2.1e-24 86.2 19.1 1.9 2 0 0 2 2 2 1 UbiA prenyltransferase family CorA PF01544.18 CRG89948.1 - 5.2e-10 39.1 0.6 5.2e-10 39.1 0.6 2.8 3 0 0 3 3 3 1 CorA-like Mg2+ transporter protein TSNAXIP1_N PF15739.5 CRG89948.1 - 0.04 14.3 0.2 2.9 8.3 0.2 2.8 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus BssB_TutG PF18512.1 CRG89948.1 - 0.13 12.2 0.2 2.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Benzylsuccinate synthase beta subunit ADH_N PF08240.12 CRG89949.1 - 1.8e-26 92.2 0.4 3.1e-26 91.4 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG89949.1 - 2.6e-11 43.6 0.0 0.0001 22.3 0.0 2.3 2 0 0 2 2 2 2 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG89949.1 - 0.0025 17.2 0.1 0.0042 16.5 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 CRG89949.1 - 0.063 14.0 0.0 2.3 9.0 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain AlaDh_PNT_C PF01262.21 CRG89949.1 - 0.066 12.5 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CRG89949.1 - 0.079 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CRG89949.1 - 0.13 11.9 0.2 0.2 11.2 0.2 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain RTA1 PF04479.13 CRG89950.1 - 1.2e-71 240.6 9.7 1.5e-71 240.3 9.7 1.0 1 0 0 1 1 1 1 RTA1 like protein DUF3522 PF12036.8 CRG89950.1 - 0.036 14.4 0.3 0.036 14.4 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3522) EMP70 PF02990.16 CRG89950.1 - 2.2 6.8 8.5 0.49 9.0 1.1 2.1 1 1 1 2 2 2 0 Endomembrane protein 70 Fungal_trans_2 PF11951.8 CRG89951.1 - 1.6e-05 23.9 0.3 2.4e-05 23.3 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 CRG89952.1 - 2.9e-50 171.0 1.3 5.5e-50 170.1 1.3 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89952.1 - 2.2e-39 135.0 1.3 4.5e-39 133.9 1.3 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89952.1 - 6.4e-08 32.7 1.0 1.9e-07 31.2 0.8 2.0 2 1 0 2 2 2 1 KR domain Ldh_1_N PF00056.23 CRG89952.1 - 0.025 14.6 0.1 0.041 14.0 0.1 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain ThiF PF00899.21 CRG89952.1 - 0.03 13.7 0.9 0.19 11.0 0.2 2.0 2 0 0 2 2 2 0 ThiF family Polysacc_synt_2 PF02719.15 CRG89952.1 - 0.068 12.3 0.3 0.093 11.8 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 CRG89952.1 - 0.071 13.0 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AA_permease PF00324.21 CRG89953.1 - 9.4e-143 476.3 33.7 1.1e-142 476.1 33.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG89953.1 - 3e-40 138.3 34.2 3e-40 138.3 34.2 1.3 1 1 0 1 1 1 1 Amino acid permease Pro-kuma_activ PF09286.11 CRG89954.1 - 4.4e-42 143.8 0.0 1.5e-41 142.0 0.0 1.8 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG89954.1 - 3.9e-05 23.1 1.8 6.3e-05 22.4 1.8 1.2 1 0 0 1 1 1 1 Subtilase family PDDEXK_6 PF04720.12 CRG89955.1 - 0.037 14.0 1.7 0.054 13.4 1.7 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function CDC45 PF02724.14 CRG89955.1 - 2.1 6.5 8.5 2 6.6 8.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Alpha-amylase PF00128.24 CRG89957.1 - 9.6e-45 153.6 0.4 1.4e-44 153.0 0.4 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 CRG89957.1 - 7.3e-25 87.1 0.0 1.4e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Abhydrolase_6 PF12697.7 CRG89959.1 - 2e-13 51.4 0.3 2e-13 51.4 0.3 2.1 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG89959.1 - 5.9e-11 42.5 0.0 1e-10 41.7 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG89959.1 - 3.5e-07 29.7 0.0 8.9e-07 28.4 0.0 1.7 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 CRG89959.1 - 8.6e-05 21.4 0.0 0.00082 18.2 0.0 2.0 1 1 0 1 1 1 1 Ndr family EthD PF07110.11 CRG89959.1 - 0.00029 21.9 0.9 0.97 10.6 0.1 3.6 4 0 0 4 4 4 2 EthD domain Esterase PF00756.20 CRG89959.1 - 0.0035 17.0 0.0 0.0057 16.3 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Arylsulfotran_2 PF14269.6 CRG89960.1 - 1.1e-54 185.8 0.2 1.8e-54 185.2 0.2 1.3 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CRG89960.1 - 2.3e-16 59.7 0.0 1.8e-15 56.8 0.0 2.2 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) BiPBP_C PF06832.12 CRG89960.1 - 0.041 13.9 0.1 0.63 10.1 0.1 2.8 2 0 0 2 2 2 0 Penicillin-Binding Protein C-terminus Family LysM PF01476.20 CRG89961.1 - 0.00012 22.0 0.2 0.0014 18.7 0.0 2.5 3 0 0 3 3 3 1 LysM domain SLT PF01464.20 CRG89961.1 - 0.0069 16.0 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain Mucin PF01456.17 CRG89961.1 - 6.8 6.7 34.6 16 5.5 34.6 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein Ank_2 PF12796.7 CRG89962.1 - 3e-15 56.6 2.0 2.8e-06 27.8 0.7 4.6 2 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG89962.1 - 1.3e-13 51.1 0.5 2.3e-05 24.8 0.0 5.2 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG89962.1 - 1.2e-09 37.6 4.9 1.7 9.5 0.1 6.7 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 CRG89962.1 - 0.00013 22.2 1.5 3 8.3 0.0 5.4 4 1 2 6 6 6 1 Ankyrin repeats (many copies) Ank PF00023.30 CRG89962.1 - 0.00035 20.9 4.0 7.2 7.3 0.1 5.2 5 0 0 5 5 5 1 Ankyrin repeat F-box-like PF12937.7 CRG89962.1 - 0.014 15.3 0.3 0.027 14.4 0.3 1.5 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 CRG89962.1 - 0.13 12.1 0.2 0.25 11.3 0.2 1.4 1 0 0 1 1 1 0 F-box domain Bac_luciferase PF00296.20 CRG89963.1 - 2.2e-57 194.9 0.0 3.9e-57 194.1 0.0 1.3 1 0 0 1 1 1 1 Luciferase-like monooxygenase SSF PF00474.17 CRG89963.1 - 2.4e-25 89.2 34.1 2.4e-25 89.2 34.1 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family DUF5056 PF16479.5 CRG89963.1 - 1.2 9.4 3.2 7.2 6.9 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5056) Pkinase PF00069.25 CRG89964.1 - 2.6e-15 56.5 0.0 8.4e-08 31.9 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain MFS_1 PF07690.16 CRG89964.1 - 8.7e-14 51.2 44.3 1.2e-08 34.3 29.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase_Tyr PF07714.17 CRG89964.1 - 2.9e-06 26.8 0.2 0.12 11.6 0.0 3.3 3 0 0 3 3 3 2 Protein tyrosine kinase Zn_clus PF00172.18 CRG89964.1 - 0.1 12.7 1.4 0.22 11.7 1.4 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain ENOD40 PF08247.11 CRG89964.1 - 2.5 8.3 4.4 31 4.8 0.5 2.8 2 0 0 2 2 2 0 ENOD40 protein Pyr_redox_2 PF07992.14 CRG89965.1 - 5.5e-13 48.8 0.0 1.4e-09 37.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG89965.1 - 0.022 14.8 0.0 0.13 12.3 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 CRG89965.1 - 0.022 14.3 1.4 0.032 13.8 0.2 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Kelch_1 PF01344.25 CRG89965.1 - 0.13 11.9 0.1 0.45 10.2 0.1 1.9 2 0 0 2 2 2 0 Kelch motif Sacchrp_dh_NADP PF03435.18 CRG89965.1 - 0.2 11.9 0.1 0.43 10.9 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SGL PF08450.12 CRG89966.1 - 3.1e-67 226.7 1.2 4.9e-67 226.1 1.2 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region adh_short_C2 PF13561.6 CRG89966.1 - 4.8e-44 150.7 0.0 1e-43 149.6 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89966.1 - 7e-41 139.8 0.1 1.5e-40 138.7 0.1 1.6 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG89966.1 - 3.4e-07 30.3 0.0 8.6e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG89966.1 - 0.0003 20.3 0.4 0.00079 18.9 0.0 1.9 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 CRG89966.1 - 0.00096 18.7 0.6 0.021 14.3 0.2 3.3 3 1 0 3 3 3 1 NAD dependent epimerase/dehydratase family DUF3069 PF11269.8 CRG89966.1 - 0.018 15.3 0.1 0.053 13.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) PLC-beta_C PF08703.10 CRG89966.1 - 0.06 13.3 3.7 0.034 14.1 0.8 2.1 2 0 0 2 2 2 0 PLC-beta C terminal Reg_prop PF07494.11 CRG89966.1 - 0.095 13.0 1.1 24 5.6 0.3 3.0 2 0 0 2 2 2 0 Two component regulator propeller Phytase-like PF13449.6 CRG89966.1 - 0.13 12.2 0.6 2.6 7.9 0.0 2.7 2 1 1 3 3 3 0 Esterase-like activity of phytase GDP_Man_Dehyd PF16363.5 CRG89966.1 - 0.31 10.4 3.0 0.24 10.8 0.0 2.3 3 0 0 3 3 3 0 GDP-mannose 4,6 dehydratase Beta-lactamase PF00144.24 CRG89967.1 - 2.5e-65 220.9 0.1 3.2e-65 220.5 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase TPR_5 PF12688.7 CRG89967.1 - 0.12 12.6 0.1 2.1 8.6 0.1 2.2 2 0 0 2 2 2 0 Tetratrico peptide repeat DUF3425 PF11905.8 CRG89968.1 - 2.6e-19 69.4 2.5 2.6e-19 69.4 2.5 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) Beta-lactamase PF00144.24 CRG89970.1 - 8.8e-54 183.0 2.0 1.3e-53 182.3 2.0 1.2 1 0 0 1 1 1 1 Beta-lactamase DUF3471 PF11954.8 CRG89970.1 - 2.3e-14 53.7 0.0 4.3e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Acetyltransf_1 PF00583.25 CRG89971.1 - 5.6e-11 42.7 0.0 7.3e-11 42.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG89971.1 - 2.8e-10 40.5 0.0 3.9e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG89971.1 - 4.9e-08 33.0 0.0 1.5e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG89971.1 - 3.4e-05 23.7 0.1 9.2e-05 22.3 0.1 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CRG89971.1 - 0.00042 20.4 0.0 0.00073 19.6 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 CRG89971.1 - 0.05 13.6 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 CRG89971.1 - 0.059 12.8 0.0 0.079 12.4 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase ATP-synt_C PF00137.21 CRG89972.1 - 6e-10 39.3 10.9 1.1e-09 38.4 10.9 1.5 1 0 0 1 1 1 1 ATP synthase subunit C Tir_receptor_C PF07489.11 CRG89972.1 - 0.0087 16.1 0.3 0.016 15.2 0.3 1.4 1 0 0 1 1 1 1 Translocated intimin receptor (Tir) C-terminus MFS_1 PF07690.16 CRG89973.1 - 2.7e-23 82.5 18.8 2.7e-23 82.5 18.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Pex24p PF06398.11 CRG89973.1 - 0.11 11.4 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Myc_target_1 PF15179.6 CRG89974.1 - 0.094 12.6 3.2 0.2 11.5 3.2 1.5 1 0 0 1 1 1 0 Myc target protein 1 Glyco_transf_15 PF01793.16 CRG89975.1 - 3.3e-115 384.8 9.7 4.5e-115 384.3 9.7 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase 2OG-FeII_Oxy_3 PF13640.6 CRG89976.1 - 3.2e-08 34.3 0.0 5.6e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RabGAP-TBC PF00566.18 CRG89977.1 - 5.3e-32 111.2 0.1 1.1e-31 110.2 0.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain SBE2 PF17076.5 CRG89977.1 - 2.1e-07 29.6 3.9 2.1e-07 29.6 3.9 2.0 1 1 1 2 2 2 1 SBE2, cell-wall formation Sigma70_r3 PF04539.16 CRG89977.1 - 0.055 13.6 0.1 0.2 11.8 0.1 1.9 1 0 0 1 1 1 0 Sigma-70 region 3 EzrA PF06160.12 CRG89977.1 - 0.087 11.0 1.6 0.18 10.0 1.6 1.4 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA HhH-GPD PF00730.25 CRG89978.1 - 1.9e-05 25.1 0.0 4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Fungal_trans PF04082.18 CRG89979.1 - 5.5e-22 78.1 0.0 3.4e-21 75.5 0.0 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89979.1 - 3e-08 33.7 10.7 6.4e-08 32.6 10.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG89980.1 - 1.3e-23 83.3 0.1 1.9e-23 82.9 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG89980.1 - 3e-08 33.7 7.5 3e-08 33.7 7.5 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Amidohydro_2 PF04909.14 CRG89981.1 - 3.2e-36 125.6 0.1 3.8e-36 125.4 0.1 1.0 1 0 0 1 1 1 1 Amidohydrolase adh_short_C2 PF13561.6 CRG89982.1 - 4e-13 49.5 0.1 5e-13 49.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG89982.1 - 4.5e-12 45.8 0.0 6e-12 45.4 0.0 1.3 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 CRG89982.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG89982.1 - 0.001 19.0 0.1 0.0015 18.5 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG89982.1 - 0.0026 17.4 0.1 0.0053 16.3 0.1 1.5 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 CRG89982.1 - 0.036 13.2 0.1 0.051 12.7 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Ank_2 PF12796.7 CRG89983.1 - 8.1e-38 128.9 0.2 2.1e-09 37.8 0.0 4.9 1 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG89983.1 - 7.8e-28 96.5 3.1 3.4e-05 24.3 0.0 6.6 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG89983.1 - 7.5e-26 87.4 2.3 7.5e-05 22.8 0.0 10.0 10 1 0 10 10 10 5 Ankyrin repeat Ank_5 PF13857.6 CRG89983.1 - 6e-23 80.6 6.7 0.00045 20.4 0.0 6.6 3 3 4 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG89983.1 - 1.7e-21 75.6 3.8 0.16 12.5 0.0 8.6 9 0 0 9 9 9 7 Ankyrin repeat T5orf172 PF10544.9 CRG89984.1 - 7.7e-10 39.2 0.0 1.4e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 CRG89984.1 - 4.8e-06 27.2 0.6 7.4e-06 26.6 0.1 1.6 2 0 0 2 2 2 1 Meiotically up-regulated gene 113 Fungal_trans PF04082.18 CRG89986.1 - 7.8e-11 41.5 0.0 1.6e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_L37ae PF01780.19 CRG89987.1 - 3e-37 126.6 5.6 3.9e-37 126.2 5.6 1.1 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 CRG89987.1 - 0.027 14.6 1.5 0.098 12.8 1.9 1.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-FCS PF06467.14 CRG89987.1 - 0.07 13.1 2.1 7.5 6.6 0.2 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif Zn_Tnp_IS1595 PF12760.7 CRG89987.1 - 0.12 12.4 3.7 0.22 11.5 3.7 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 CRG89987.1 - 0.12 12.7 2.1 2.6 8.4 2.1 2.1 1 1 1 2 2 2 0 C1 domain A2L_zn_ribbon PF08792.10 CRG89987.1 - 0.15 11.9 2.9 9.8 6.0 0.0 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain Amidohydro_3 PF07969.11 CRG89988.1 - 1.7e-11 44.3 0.2 8.8e-06 25.4 0.0 2.9 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 CRG89988.1 - 6.2e-11 42.2 0.6 4e-08 33.0 0.0 3.2 3 1 0 3 3 3 2 Amidohydrolase family adh_short PF00106.25 CRG89989.1 - 4.9e-40 137.1 0.2 6.3e-40 136.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG89989.1 - 2e-31 109.4 0.1 2.7e-31 108.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG89989.1 - 6.5e-07 29.4 0.2 1.8e-05 24.7 0.2 2.2 1 1 0 1 1 1 1 KR domain FAA_hydrolase PF01557.18 CRG89990.1 - 7.5e-56 189.2 0.0 1.1e-55 188.7 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CRG89990.1 - 1.6e-28 99.0 0.0 2.5e-27 95.2 0.0 2.2 2 0 0 2 2 2 1 Fumarylacetoacetase N-terminal ADH_zinc_N PF00107.26 CRG89991.1 - 2.6e-23 82.4 0.4 5.1e-23 81.5 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG89991.1 - 1.6e-21 76.3 0.4 3.4e-21 75.2 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 CRG89991.1 - 0.013 14.9 0.5 0.039 13.3 0.3 1.8 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 CRG89991.1 - 0.023 14.0 1.4 0.038 13.3 1.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG89991.1 - 0.025 15.6 0.0 0.043 14.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase TrkA_N PF02254.18 CRG89991.1 - 0.06 13.6 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Tannase PF07519.11 CRG89992.1 - 1.7e-107 360.2 0.7 2.4e-107 359.8 0.7 1.1 1 0 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 CRG89992.1 - 0.12 11.6 0.0 0.49 9.6 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Glyco_hydro_3 PF00933.21 CRG89994.1 - 3.6e-57 194.2 0.0 4.3e-57 193.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Cation_ATPase_C PF00689.21 CRG89995.1 - 7.2e-40 136.6 7.0 7.2e-40 136.6 7.0 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 CRG89995.1 - 2.6e-37 128.1 5.9 1.4e-36 125.7 5.1 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 CRG89995.1 - 8.7e-20 70.6 0.0 1.9e-19 69.6 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG89995.1 - 2.2e-16 60.8 0.1 1.2e-06 29.0 0.1 3.3 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG89995.1 - 6.9e-14 51.3 0.0 1.8e-13 50.0 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CRG89995.1 - 1.5e-05 24.9 0.6 2.7e-05 24.0 0.6 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase RSRP PF17069.5 CRG89995.1 - 1.5 8.4 15.3 2.6 7.5 15.3 1.3 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 DctQ PF04290.12 CRG89995.1 - 5.5 6.9 21.6 0.072 13.0 2.9 3.9 4 0 0 4 4 4 0 Tripartite ATP-independent periplasmic transporters, DctQ component Asp PF00026.23 CRG89996.1 - 3.4e-60 204.1 3.9 8.9e-60 202.7 3.9 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG89996.1 - 2.6e-10 40.8 1.8 3.5e-05 24.1 0.0 2.7 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 CRG89996.1 - 7.6e-06 25.8 0.0 1.8e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 CRG89996.1 - 2.3e-05 24.9 2.0 0.0079 16.8 0.1 3.4 3 2 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 CRG89996.1 - 0.01 16.4 0.1 11 6.6 0.0 3.7 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease SHIPPO-rpt PF07004.12 CRG89996.1 - 0.59 11.2 2.4 2.7 9.0 2.4 2.3 1 1 0 1 1 1 0 Sperm-tail PG-rich repeat SUR7 PF06687.12 CRG89997.1 - 4.4e-49 167.0 8.6 5.2e-49 166.7 8.6 1.1 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 CRG89997.1 - 0.0045 16.9 1.8 0.0045 16.9 1.8 1.4 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 DUF373 PF04123.13 CRG89997.1 - 0.03 13.8 2.4 0.046 13.1 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) MARVEL PF01284.23 CRG89997.1 - 0.29 11.1 15.9 1 9.4 15.9 2.1 1 1 0 1 1 1 0 Membrane-associating domain WD40 PF00400.32 CRG89998.1 - 2.3e-10 40.9 21.8 0.00018 22.2 0.3 9.0 9 1 0 9 9 9 4 WD domain, G-beta repeat XPG_N PF00752.17 CRG89999.1 - 6.1e-34 116.5 0.0 1.5e-33 115.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CRG89999.1 - 2.4e-25 88.7 0.0 6.3e-25 87.4 0.0 1.8 1 0 0 1 1 1 1 XPG I-region UIM PF02809.20 CRG89999.1 - 0.00067 19.4 0.1 0.00067 19.4 0.1 3.6 3 0 0 3 3 3 1 Ubiquitin interaction motif 5_3_exonuc PF01367.20 CRG89999.1 - 0.0017 18.9 0.0 0.0061 17.1 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Pil1 PF13805.6 CRG90000.1 - 1.8e-127 424.4 0.1 2.9e-127 423.6 0.1 1.3 1 0 0 1 1 1 1 Eisosome component PIL1 RhoGAP PF00620.27 CRG90001.1 - 0.036 13.9 0.5 0.081 12.7 0.5 1.6 1 0 0 1 1 1 0 RhoGAP domain YlbD_coat PF14071.6 CRG90001.1 - 0.47 10.7 4.8 0.21 11.9 1.6 2.0 2 0 0 2 2 2 0 Putative coat protein DUF1932 PF09130.11 CRG90002.1 - 4.9e-22 77.7 0.2 5.6e-21 74.3 0.1 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF1932) bZIP_2 PF07716.15 CRG90002.1 - 6e-11 42.3 11.0 6e-11 42.3 11.0 2.3 2 0 0 2 2 2 1 Basic region leucine zipper NAD_binding_2 PF03446.15 CRG90002.1 - 1.6e-06 28.4 0.0 3.6e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CRG90002.1 - 1.7e-05 25.3 0.1 1.7e-05 25.3 0.1 2.3 3 0 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 CRG90002.1 - 0.007 15.7 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain bZIP_1 PF00170.21 CRG90002.1 - 0.17 12.0 11.8 0.47 10.6 11.8 1.7 1 0 0 1 1 1 0 bZIP transcription factor DUF2368 PF10166.9 CRG90002.1 - 0.57 9.8 6.7 1.5 8.5 6.7 1.7 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) Exonuc_VII_L PF02601.15 CRG90002.1 - 0.77 9.3 11.8 0.93 9.0 4.5 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Neur_chan_memb PF02932.16 CRG90002.1 - 6.2 6.8 6.5 29 4.6 3.4 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4094 PF13334.6 CRG90002.1 - 7.2 7.1 7.7 1.1 9.7 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Ribonuclease_T2 PF00445.18 CRG90003.1 - 5.6e-35 121.2 0.0 8e-35 120.7 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Exo_endo_phos PF03372.23 CRG90004.1 - 6.9e-08 32.3 0.1 9.3e-08 31.9 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SesA PF17107.5 CRG90005.1 - 6.3e-36 123.2 0.1 2.2e-35 121.5 0.1 2.0 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Ank_2 PF12796.7 CRG90005.1 - 1.3e-29 102.5 0.0 2.8e-11 43.9 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Abhydrolase_1 PF00561.20 CRG90005.1 - 1.2e-15 57.8 0.0 3.2e-15 56.5 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ank_5 PF13857.6 CRG90005.1 - 3.7e-14 52.6 0.1 0.00014 22.1 0.0 4.2 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG90005.1 - 9e-14 51.7 0.0 6.4e-05 23.4 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG90005.1 - 8e-13 48.2 0.0 0.11 13.0 0.0 6.0 5 0 0 5 5 5 3 Ankyrin repeat Abhydrolase_6 PF12697.7 CRG90005.1 - 1.7e-11 45.1 0.0 4.5e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ank_3 PF13606.6 CRG90005.1 - 1.1e-10 40.8 0.1 0.21 12.3 0.0 5.8 6 0 0 6 6 4 2 Ankyrin repeat PGAP1 PF07819.13 CRG90005.1 - 6e-07 29.4 0.0 1.5e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 CRG90005.1 - 8.9e-07 28.4 0.0 1.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 NACHT PF05729.12 CRG90005.1 - 2.5e-05 24.2 0.0 5.5e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Esterase PF00756.20 CRG90005.1 - 0.00092 18.9 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Chlorophyllase PF07224.11 CRG90005.1 - 0.033 13.2 0.0 0.058 12.4 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase HAP2-GCS1 PF10699.9 CRG90005.1 - 0.061 13.3 0.0 0.19 11.7 0.0 1.8 1 0 0 1 1 1 0 Male gamete fusion factor AAA_16 PF13191.6 CRG90005.1 - 0.091 13.1 0.8 13 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA ATPase domain NACHT_sigma PF17106.5 CRG90005.1 - 3.4 7.9 8.5 10 6.4 8.5 1.8 1 1 0 1 1 1 0 Sigma domain on NACHT-NTPases COesterase PF00135.28 CRG90006.1 - 3.2e-95 319.9 0.0 3.9e-95 319.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG90006.1 - 1.6e-06 28.1 0.2 0.011 15.6 0.0 3.0 3 0 0 3 3 3 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG90006.1 - 0.022 14.2 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family ADH_N PF08240.12 CRG90007.1 - 4.5e-25 87.7 6.2 6.9e-25 87.1 6.2 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG90007.1 - 1.1e-11 44.9 0.0 1.8e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG90007.1 - 0.00052 19.4 0.0 0.00089 18.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 CRG90007.1 - 0.0096 15.7 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Haem_degrading PF03928.14 CRG90007.1 - 0.06 13.4 0.3 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 Haem-degrading Fungal_trans PF04082.18 CRG90008.1 - 2.4e-21 76.0 0.1 3.5e-21 75.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydr_116N PF12215.8 CRG90008.1 - 0.025 14.0 0.0 2.3 7.6 0.0 2.4 2 0 0 2 2 2 0 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term Spc7_N PF15402.6 CRG90009.1 - 0 1126.8 64.8 0 1126.8 64.8 2.4 2 0 0 2 2 2 1 N-terminus of kinetochore NMS complex subunit Spc7 Spc7 PF08317.11 CRG90009.1 - 1.1e-122 408.8 0.0 2.7e-122 407.5 0.0 1.6 1 0 0 1 1 1 1 Spc7 kinetochore protein Fungal_trans PF04082.18 CRG90009.1 - 1.5e-21 76.7 0.9 1.5e-21 76.7 0.9 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain HMMR_N PF15905.5 CRG90009.1 - 0.23 10.9 10.2 0.72 9.3 10.2 1.8 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Syntaxin-6_N PF09177.11 CRG90009.1 - 2.1 8.9 5.9 61 4.3 1.4 3.8 3 0 0 3 3 3 0 Syntaxin 6, N-terminal Ribosomal_S17_N PF16205.5 CRG90010.1 - 1.1e-33 115.4 0.2 1.7e-33 114.8 0.2 1.3 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 CRG90010.1 - 1.2e-26 92.6 0.4 2.3e-26 91.7 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 ANTH PF07651.16 CRG90012.1 - 3e-61 206.9 0.1 4e-61 206.5 0.1 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 CRG90012.1 - 4.6e-06 26.7 0.0 3.9e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 ENTH domain MatK_N PF01824.18 CRG90012.1 - 0.18 11.4 0.0 0.27 10.9 0.0 1.2 1 0 0 1 1 1 0 MatK/TrnK amino terminal region Fungal_trans_2 PF11951.8 CRG90013.1 - 7.6e-12 44.7 1.3 1.4e-11 43.9 1.3 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain RAP1 PF07218.11 CRG90013.1 - 0.63 8.2 7.2 0.89 7.8 7.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Macoilin PF09726.9 CRG90013.1 - 5.2 5.5 7.2 6.9 5.1 7.2 1.1 1 0 0 1 1 1 0 Macoilin family Gpr1_Fun34_YaaH PF01184.19 CRG90014.1 - 7.6e-90 300.0 15.5 9.2e-90 299.8 15.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Mis12 PF05859.12 CRG90015.1 - 0.94 9.5 4.2 80 3.3 4.2 2.8 1 1 0 1 1 1 0 Mis12 protein DUF2894 PF11445.8 CRG90016.1 - 0.73 10.3 5.8 0.52 10.8 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) WD40 PF00400.32 CRG90017.1 - 5.9e-21 74.4 12.9 0.00039 21.2 0.1 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90017.1 - 1.8e-16 60.2 0.0 7.3e-05 23.0 0.0 5.6 4 2 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG90017.1 - 2.8e-05 24.1 0.4 0.015 15.1 0.0 3.0 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A HIRA_B PF09453.10 CRG90017.1 - 0.00027 20.7 0.3 0.00088 19.1 0.3 1.9 1 0 0 1 1 1 1 HIRA B motif Ge1_WD40 PF16529.5 CRG90017.1 - 0.0013 17.7 0.2 6.6 5.6 0.0 4.0 3 2 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 CRG90017.1 - 0.011 15.7 6.1 6.2 6.9 0.3 4.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat SGL PF08450.12 CRG90017.1 - 0.097 12.2 0.1 0.49 9.9 0.0 2.1 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Oxidored_FMN PF00724.20 CRG90018.1 - 5.5e-94 315.2 0.0 7e-94 314.9 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Glyco_transf_20 PF00982.21 CRG90019.1 - 1.2e-145 485.8 0.0 1.7e-145 485.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 CRG90019.1 - 8e-21 74.2 0.0 1.6e-20 73.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Kri1_C PF12936.7 CRG90019.1 - 0.039 14.1 0.0 0.092 12.9 0.0 1.6 1 0 0 1 1 1 0 KRI1-like family C-terminal K_channel_TID PF07941.11 CRG90019.1 - 2.7 8.5 5.7 6.6 7.3 5.7 1.5 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain Glyco_transf_20 PF00982.21 CRG90020.1 - 5.7e-195 648.5 0.0 6.4e-195 648.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 CRG90020.1 - 0.066 12.7 0.2 12 5.4 0.0 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 Rad4 PF03835.15 CRG90022.1 - 1.6e-12 47.3 0.9 3.2e-12 46.4 0.9 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 CRG90022.1 - 2.8e-10 40.6 2.0 6.6e-10 39.4 2.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily Cellulase PF00150.18 CRG90023.1 - 7.4e-54 183.1 3.9 9.2e-54 182.8 3.9 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DUF1554 PF07588.11 CRG90023.1 - 0.029 14.1 3.9 0.36 10.6 0.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1554) DUF3255 PF11631.8 CRG90023.1 - 0.085 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3255) AMP-binding PF00501.28 CRG90024.1 - 1.3e-210 699.4 0.0 5.2e-70 236.2 0.0 3.3 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 CRG90024.1 - 2.8e-157 524.1 0.0 2.4e-36 125.4 0.1 5.2 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 CRG90024.1 - 2.4e-44 149.5 15.8 7.3e-11 42.3 0.2 5.9 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG90024.1 - 4.7e-13 49.9 0.0 0.00021 22.2 0.0 4.2 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain ABC_membrane PF00664.23 CRG90025.1 - 6.5e-88 294.9 30.9 1.4e-44 152.8 14.9 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG90025.1 - 3.4e-62 209.0 0.0 4.9e-31 108.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG90025.1 - 1.6e-15 57.1 0.5 0.00095 18.7 0.0 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG90025.1 - 2.2e-09 37.7 0.4 0.04 14.2 0.1 4.0 3 1 0 3 3 3 2 AAA domain ABC_ATPase PF09818.9 CRG90025.1 - 2.9e-09 36.3 0.0 6.8e-05 21.8 0.0 3.3 4 0 0 4 4 4 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 CRG90025.1 - 1.2e-08 35.6 1.0 0.0018 18.7 0.1 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 CRG90025.1 - 6.1e-08 32.3 0.1 0.0032 17.2 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 CRG90025.1 - 2.6e-05 24.2 1.1 0.033 14.0 0.1 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 CRG90025.1 - 3.6e-05 23.6 0.3 0.15 11.8 0.0 3.8 4 0 0 4 4 4 1 AAA domain DUF87 PF01935.17 CRG90025.1 - 4.6e-05 23.6 0.0 0.038 14.1 0.0 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 CRG90025.1 - 7.3e-05 22.7 0.1 0.43 10.5 0.0 2.9 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CRG90025.1 - 0.00017 22.1 0.1 0.58 10.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 CRG90025.1 - 0.00026 20.7 0.0 0.13 11.9 0.0 3.8 4 0 0 4 4 4 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CRG90025.1 - 0.0012 18.6 0.0 2.6 7.7 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_5 PF07728.14 CRG90025.1 - 0.0016 18.4 0.1 2.2 8.3 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 CRG90025.1 - 0.0018 18.1 0.0 1.5 8.4 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 CRG90025.1 - 0.0033 17.7 0.2 9.5 6.4 0.0 3.5 3 1 0 3 3 3 0 AAA domain Rad17 PF03215.15 CRG90025.1 - 0.0043 17.0 0.0 3.9 7.4 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 CRG90025.1 - 0.0046 17.5 0.0 4.6 7.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CRG90025.1 - 0.0074 15.8 0.0 3.7 7.0 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_25 PF13481.6 CRG90025.1 - 0.0087 15.7 0.0 1.9 8.0 0.0 3.2 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.20 CRG90025.1 - 0.0093 15.2 0.0 0.47 9.6 0.0 2.2 2 0 0 2 2 2 1 G-protein alpha subunit AAA_33 PF13671.6 CRG90025.1 - 0.011 15.9 0.0 2.1 8.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CRG90025.1 - 0.016 15.0 0.1 5.2 6.8 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase SbcCD_C PF13558.6 CRG90025.1 - 0.021 15.0 3.1 2.8 8.2 0.2 3.9 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF3987 PF13148.6 CRG90025.1 - 0.026 13.5 0.0 3.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Zeta_toxin PF06414.12 CRG90025.1 - 0.034 13.4 0.0 5.4 6.2 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin APS_kinase PF01583.20 CRG90025.1 - 0.082 12.8 0.0 1.6 8.6 0.0 2.4 2 0 0 2 2 2 0 Adenylylsulphate kinase PRK PF00485.18 CRG90025.1 - 0.086 12.6 0.1 5.5 6.7 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family IstB_IS21 PF01695.17 CRG90025.1 - 0.1 12.3 0.9 22 4.7 0.0 3.6 4 0 0 4 4 4 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 CRG90025.1 - 0.1 12.7 1.4 3.1 7.9 0.0 2.9 3 0 0 3 3 2 0 50S ribosome-binding GTPase CARDB PF07705.11 CRG90025.1 - 0.11 12.8 0.3 0.59 10.4 0.1 2.3 2 0 0 2 2 2 0 CARDB ATP_bind_1 PF03029.17 CRG90025.1 - 0.12 12.2 0.3 17 5.1 0.0 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 CRG90025.1 - 0.14 11.3 0.3 0.94 8.6 0.0 2.3 3 0 0 3 3 3 0 NB-ARC domain DUF3671 PF12420.8 CRG90025.1 - 7.4 6.7 8.1 5.7 7.0 3.1 3.4 3 2 0 3 3 3 0 Protein of unknown function NAD_binding_6 PF08030.12 CRG90026.1 - 1.1e-22 80.8 0.0 1.5e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 CRG90026.1 - 6.5e-18 65.1 10.9 7.8e-18 64.8 8.1 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 CRG90026.1 - 3.6e-11 43.1 0.0 6.7e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 CRG90026.1 - 0.12 13.0 0.0 2.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain PIP5K PF01504.18 CRG90028.1 - 9.2e-35 120.2 0.1 7.6e-26 90.9 0.1 2.8 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 CRG90028.1 - 8.9e-30 103.7 0.0 2.5e-29 102.2 0.0 1.7 2 0 0 2 2 2 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 CRG90028.1 - 3.8e-15 55.8 4.6 3.8e-15 55.8 4.6 2.0 2 0 0 2 2 2 1 FYVE zinc finger C1_1 PF00130.22 CRG90028.1 - 0.0072 16.2 2.8 0.022 14.7 2.8 1.8 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 CRG90028.1 - 1.8 8.7 5.2 2 8.5 2.9 2.3 2 0 0 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 CRG90028.1 - 6.7 7.1 8.2 5.1 7.5 4.7 2.5 2 0 0 2 2 2 0 C1 domain Pro-kuma_activ PF09286.11 CRG90029.1 - 1.7e-43 148.3 0.0 3.1e-43 147.5 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG90029.1 - 0.049 12.9 0.8 0.084 12.1 0.8 1.3 1 0 0 1 1 1 0 Subtilase family Asp PF00026.23 CRG90030.1 - 4.1e-38 131.6 0.2 4.8e-38 131.3 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG90030.1 - 2.8e-05 24.4 4.4 0.0057 16.9 4.0 2.8 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal PK PF00224.21 CRG90031.1 - 2.1e-176 585.9 2.7 2.8e-176 585.5 2.7 1.2 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 CRG90031.1 - 2.8e-38 130.7 0.0 9.7e-38 129.0 0.0 2.0 2 0 0 2 2 2 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 CRG90031.1 - 6.7e-05 22.1 0.2 0.00017 20.8 0.1 1.7 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 CRG90031.1 - 0.016 14.2 0.1 0.19 10.7 0.0 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain NTP_transf_2 PF01909.23 CRG90031.1 - 0.059 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF1748 PF08520.10 CRG90032.1 - 4.6e-37 125.8 0.1 5.2e-37 125.6 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) DUF3506 PF12014.8 CRG90033.1 - 2.4e-50 170.1 0.0 4.2e-50 169.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 CRG90033.1 - 1.2e-08 34.7 0.1 2.3e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG90033.1 - 1.8e-08 34.0 0.0 4.8e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 F-box domain NRBF2 PF08961.10 CRG90034.1 - 3.2e-05 23.6 2.7 3.2e-05 23.6 2.7 2.6 2 0 0 2 2 2 1 Nuclear receptor-binding factor 2, autophagy regulator CENP-H PF05837.12 CRG90034.1 - 9.5e-05 22.8 3.5 9.5e-05 22.8 3.5 4.1 3 1 1 4 4 4 1 Centromere protein H (CENP-H) TMF_TATA_bd PF12325.8 CRG90034.1 - 0.00043 20.5 4.3 0.00043 20.5 4.3 4.6 4 1 1 5 5 5 1 TATA element modulatory factor 1 TATA binding YjcZ PF13990.6 CRG90034.1 - 0.00095 18.6 14.4 0.033 13.5 4.5 2.5 1 1 1 2 2 2 2 YjcZ-like protein Laminin_II PF06009.12 CRG90034.1 - 0.0072 16.3 14.4 0.34 10.9 0.7 3.6 2 1 1 3 3 3 2 Laminin Domain II GAS PF13851.6 CRG90034.1 - 0.047 13.0 31.1 1.7 8.0 7.1 4.5 2 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding TPR_12 PF13424.6 CRG90034.1 - 0.15 12.4 2.3 0.77 10.1 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF533 PF04391.12 CRG90034.1 - 0.19 11.3 3.7 0.45 10.1 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Sec34 PF04136.15 CRG90034.1 - 0.2 11.5 15.6 0.64 9.9 0.9 3.6 2 1 2 4 4 4 0 Sec34-like family UPF0242 PF06785.11 CRG90034.1 - 1.1 9.4 38.6 0.052 13.6 10.5 3.4 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Rootletin PF15035.6 CRG90034.1 - 1.3 9.0 37.7 0.1 12.6 19.4 3.3 2 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion FlaC_arch PF05377.11 CRG90034.1 - 3.9 7.9 8.0 12 6.4 0.2 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) AcylCoA_dehyd_C PF12186.8 CRG90034.1 - 4.1 7.6 8.9 5.2 7.2 0.9 3.8 3 1 1 4 4 4 0 Acyl-CoA dehydrogenase C terminal TACC_C PF05010.14 CRG90034.1 - 5.2 6.8 29.2 5.8 6.6 6.6 3.9 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF948 PF06103.11 CRG90034.1 - 7.9 6.8 8.0 5 7.4 1.5 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Fungal_trans PF04082.18 CRG90035.1 - 3.2e-06 26.4 1.2 1.2e-05 24.4 0.0 2.3 3 0 0 3 3 3 1 Fungal specific transcription factor domain Palm_thioest PF02089.15 CRG90035.1 - 0.053 13.4 0.0 0.089 12.6 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF1769 PF08588.10 CRG90036.1 - 6.5e-27 93.5 0.7 1.4e-26 92.5 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Alpha-amylase PF00128.24 CRG90037.1 - 9.8e-67 225.9 0.6 1.5e-66 225.3 0.6 1.2 1 0 0 1 1 1 1 Alpha amylase, catalytic domain CBM_20 PF00686.19 CRG90037.1 - 2.3e-24 85.1 0.1 5.6e-24 83.9 0.1 1.6 1 0 0 1 1 1 1 Starch binding domain DUF1966 PF09260.11 CRG90037.1 - 1.7e-14 53.9 0.0 3.8e-14 52.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Glyco_hydro_15 PF00723.21 CRG90038.1 - 3.9e-103 345.6 1.5 4.9e-103 345.3 1.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 CRG90038.1 - 3e-36 123.2 0.3 3e-36 123.2 0.3 2.1 2 0 0 2 2 2 1 Starch binding domain Iso_dh PF00180.20 CRG90039.1 - 3.9e-98 328.8 0.0 5.9e-98 328.2 0.0 1.2 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PIN_8 PF18476.1 CRG90041.1 - 0.023 14.5 0.3 0.035 14.0 0.3 1.2 1 0 0 1 1 1 0 PIN like domain 3Beta_HSD PF01073.19 CRG90042.1 - 3.9e-45 154.0 0.0 4.8e-45 153.7 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG90042.1 - 6.9e-33 114.1 0.0 8.5e-33 113.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG90042.1 - 4.8e-16 59.1 0.0 1.7e-15 57.2 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 CRG90042.1 - 6.1e-10 38.7 0.0 8.5e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG90042.1 - 1.9e-09 37.1 0.0 3.7e-07 29.6 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CRG90042.1 - 7e-08 31.9 0.5 4.3e-07 29.4 0.3 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CRG90042.1 - 4.3e-07 30.0 0.0 6.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CRG90042.1 - 3e-06 27.3 0.6 1.7e-05 24.8 0.6 1.9 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 CRG90042.1 - 0.0003 20.3 0.3 0.00051 19.5 0.1 1.6 2 0 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG90042.1 - 0.0098 16.2 0.1 0.019 15.2 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain adh_short_C2 PF13561.6 CRG90042.1 - 0.051 13.1 0.1 0.11 12.0 0.0 1.5 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Ldh_1_N PF00056.23 CRG90042.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CRG90043.1 - 3.7e-09 36.0 3.1 8.7e-09 34.8 3.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_S8 PF00410.19 CRG90043.1 - 0.00057 19.8 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S8 Trp_repressor PF01371.19 CRG90043.1 - 0.16 12.1 0.6 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 Trp repressor protein DUF1917 PF08939.10 CRG90044.1 - 6 6.7 5.9 2.1 8.2 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1917) FAD_binding_3 PF01494.19 CRG90046.1 - 1.1e-18 67.7 0.0 1.6e-14 53.9 0.0 2.9 2 1 1 3 3 3 2 FAD binding domain DAO PF01266.24 CRG90046.1 - 4.8e-05 23.1 0.0 8.2e-05 22.3 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG90046.1 - 0.00089 18.6 0.0 0.0016 17.7 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG90046.1 - 0.0032 16.2 0.2 0.0056 15.4 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 CRG90046.1 - 0.0036 16.7 0.3 0.018 14.4 0.0 2.2 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG90046.1 - 0.0083 16.3 0.0 0.022 15.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CRG90046.1 - 0.017 14.3 0.1 0.034 13.2 0.1 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CRG90046.1 - 0.036 13.4 0.3 0.056 12.7 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CRG90046.1 - 0.079 13.5 0.5 0.39 11.3 0.3 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CRG90046.1 - 0.22 10.5 0.0 0.35 9.9 0.0 1.3 1 0 0 1 1 1 0 Squalene epoxidase Peptidase_M24 PF00557.24 CRG90047.1 - 1.5e-47 162.0 0.1 1.8e-47 161.8 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 CRG90047.1 - 1e-19 70.5 5.3 2e-19 69.6 5.3 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 CRG90047.1 - 0.00048 20.1 2.8 0.00048 20.1 2.8 2.1 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 CRG90047.1 - 0.2 11.5 3.4 0.49 10.3 3.4 1.6 1 0 0 1 1 1 0 HIT zinc finger MFS_1 PF07690.16 CRG90048.1 - 8.5e-45 153.2 55.6 2.1e-44 151.9 51.5 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90048.1 - 6.7e-14 51.6 10.2 6.7e-14 51.6 10.2 3.2 3 1 0 3 3 3 2 Sugar (and other) transporter EF-hand_1 PF00036.32 CRG90049.1 - 5.5e-12 44.3 9.7 6.7e-05 22.2 0.5 3.7 3 0 0 3 3 3 2 EF hand ZZ PF00569.17 CRG90049.1 - 1.7e-10 40.6 5.5 2.8e-10 39.8 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_6 PF13405.6 CRG90049.1 - 1.1e-09 37.4 6.6 0.0001 21.9 0.3 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 CRG90049.1 - 1.6e-09 38.1 2.2 8e-05 23.0 0.1 3.9 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 CRG90049.1 - 2.5e-05 24.0 5.2 0.11 12.4 0.1 3.5 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 CRG90049.1 - 0.00066 19.1 5.8 0.21 11.1 0.8 3.3 3 0 0 3 3 3 2 EF hand C1_2 PF03107.16 CRG90049.1 - 0.0029 17.9 4.2 0.0052 17.1 4.2 1.4 1 0 0 1 1 1 1 C1 domain WD40 PF00400.32 CRG90050.1 - 7.9e-30 102.5 7.2 3.3e-06 27.7 0.0 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90050.1 - 3.9e-14 52.7 0.0 0.00016 21.9 0.0 4.6 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 CRG90050.1 - 0.00036 20.2 0.0 0.00079 19.1 0.0 1.6 1 1 0 1 1 1 1 PQQ-like domain eIF2A PF08662.11 CRG90050.1 - 0.00097 19.1 0.2 0.41 10.5 0.0 3.3 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cornichon PF03311.14 CRG90051.1 - 1.2e-49 167.6 13.0 1.4e-49 167.4 13.0 1.0 1 0 0 1 1 1 1 Cornichon protein ABC2_membrane PF01061.24 CRG90052.1 - 1.4e-38 132.5 20.0 2.3e-38 131.7 20.0 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 CRG90052.1 - 2.8e-25 89.4 0.7 4.3e-25 88.8 0.0 1.6 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 CRG90052.1 - 2.2e-05 24.4 0.1 0.27 11.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 CRG90052.1 - 0.0025 17.0 23.4 0.0025 17.0 23.4 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.6 CRG90052.1 - 0.0041 16.8 0.0 0.0095 15.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain BNIP3 PF06553.12 CRG90052.1 - 0.013 15.2 2.8 0.029 14.1 2.8 1.5 1 0 0 1 1 1 0 BNIP3 RsgA_GTPase PF03193.16 CRG90052.1 - 0.019 14.9 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 CRG90052.1 - 0.031 14.6 0.0 0.067 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 CRG90052.1 - 0.041 14.4 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF5554 PF17709.1 CRG90052.1 - 0.052 13.7 0.2 0.18 12.0 0.2 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5554) AAA_23 PF13476.6 CRG90052.1 - 0.053 14.0 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CRG90052.1 - 0.11 12.8 0.0 0.28 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 CRG90052.1 - 0.11 11.9 0.0 0.58 9.5 0.0 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 CRG90052.1 - 0.14 11.8 0.0 0.38 10.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain Laminin_EGF PF00053.24 CRG90052.1 - 2.2 8.5 28.9 0.52 10.5 9.1 3.4 2 1 1 3 3 3 0 Laminin EGF domain Cupin_2 PF07883.11 CRG90053.1 - 1.1e-09 37.9 0.0 4.4e-05 23.1 0.0 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CRG90053.1 - 0.013 15.2 0.0 7.2 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Aminotran_1_2 PF00155.21 CRG90054.1 - 1.1e-38 133.3 0.0 1.4e-38 133.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CRG90054.1 - 1.8e-08 33.7 0.0 3.8e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CRG90054.1 - 3e-06 26.0 0.0 4.5e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CRG90054.1 - 5.7e-05 22.5 0.0 8e-05 22.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CRG90054.1 - 0.00099 18.5 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Alliinase_C PF04864.13 CRG90054.1 - 0.024 13.5 0.1 0.045 12.6 0.1 1.4 1 1 0 1 1 1 0 Allinase AAA PF00004.29 CRG90055.1 - 1.2e-15 58.1 0.0 2.6e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG90055.1 - 0.00047 20.6 0.5 0.0015 18.9 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CRG90055.1 - 0.0059 16.9 0.0 0.018 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 CRG90055.1 - 0.062 13.3 0.0 0.18 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MeaB PF03308.16 CRG90055.1 - 0.16 11.0 1.4 1.7 7.5 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 CRG90055.1 - 0.27 11.8 1.0 0.83 10.2 0.0 2.5 3 0 0 3 3 3 0 AAA domain AMP-binding PF00501.28 CRG90056.1 - 4.6e-66 223.2 0.0 7.1e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG90056.1 - 2.7e-09 37.9 0.0 1.1e-08 35.9 0.0 2.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Fungal_trans PF04082.18 CRG90057.1 - 1.5e-11 43.8 0.1 4.8e-11 42.2 0.1 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90057.1 - 1.4e-07 31.5 8.5 2.8e-07 30.6 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Microvir_lysis PF04517.12 CRG90057.1 - 0.14 12.1 0.1 4.3 7.3 0.0 3.0 3 0 0 3 3 3 0 Microvirus lysis protein (E), C terminus HlyIII PF03006.20 CRG90058.1 - 1.5e-59 201.5 22.1 1.8e-59 201.2 22.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related FmiP_Thoc5 PF09766.9 CRG90059.1 - 3.6e-31 108.8 13.9 5.4e-31 108.2 13.9 1.3 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 SPATA1_C PF15743.5 CRG90059.1 - 0.019 15.0 3.9 0.019 15.0 3.9 2.4 2 1 0 2 2 2 0 Spermatogenesis-associated C-terminus CwfJ_C_1 PF04677.15 CRG90059.1 - 0.04 13.8 1.1 0.57 10.1 0.2 2.1 1 1 1 2 2 2 0 Protein similar to CwfJ C-terminus 1 DUF4200 PF13863.6 CRG90059.1 - 0.28 11.6 16.1 0.38 11.2 1.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) RNase_E_G PF10150.9 CRG90059.1 - 0.3 10.5 4.4 0.44 9.9 0.5 2.0 2 0 0 2 2 2 0 Ribonuclease E/G family Mod_r PF07200.13 CRG90059.1 - 0.38 10.8 19.0 1.1 9.3 6.1 2.2 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Casc1_N PF15927.5 CRG90059.1 - 1.9 8.1 17.0 0.04 13.6 8.6 2.1 2 1 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus APH PF01636.23 CRG90059.1 - 2.7 7.9 10.8 11 5.9 10.8 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3450 PF11932.8 CRG90059.1 - 4.8 6.4 16.6 4 6.7 5.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF349 PF03993.12 CRG90059.1 - 5 7.5 13.6 0.46 10.8 7.4 2.3 2 1 1 3 3 3 0 Domain of Unknown Function (DUF349) PIG-S PF10510.9 CRG90060.1 - 9e-178 592.3 6.8 9e-178 592.3 6.8 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-glycan biosynthesis class S protein Sod_Fe_C PF02777.18 CRG90061.1 - 4.6e-18 65.3 0.2 2.7e-09 37.1 0.2 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Polyketide_cyc PF03364.20 CRG90062.1 - 6.5e-23 81.4 0.1 1.9e-22 79.9 0.1 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 CRG90062.1 - 2.7e-05 24.5 0.1 5.2e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SMC_hinge PF06470.13 CRG90062.1 - 0.17 12.2 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain Fungal_trans_2 PF11951.8 CRG90063.1 - 3.2e-07 29.5 6.8 2.3e-06 26.7 6.7 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90063.1 - 3.9e-07 30.1 8.5 7.4e-07 29.2 8.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_12 PF08242.12 CRG90064.1 - 2.8e-15 56.9 0.0 8e-15 55.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90064.1 - 3.3e-14 53.4 0.0 6.1e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG90064.1 - 2.8e-13 50.0 0.0 4.4e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90064.1 - 3.9e-12 46.6 0.0 7.1e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90064.1 - 2.7e-09 37.0 0.0 4.4e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG90064.1 - 1.3e-07 31.2 0.0 2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 CRG90064.1 - 9.1e-05 22.4 0.1 0.013 15.4 0.1 2.4 1 1 0 1 1 1 1 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.17 CRG90064.1 - 0.0003 20.1 0.0 0.03 13.5 0.0 2.5 1 1 2 3 3 3 2 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 CRG90064.1 - 0.00077 20.5 0.0 0.0016 19.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG90064.1 - 0.0028 17.2 0.0 0.0065 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Pec_lyase_N PF04431.13 CRG90064.1 - 0.01 16.0 0.6 0.02 15.1 0.6 1.4 1 0 0 1 1 1 0 Pectate lyase, N terminus CMAS PF02353.20 CRG90064.1 - 0.015 14.6 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase WBP-1 PF11669.8 CRG90065.1 - 0.86 10.3 4.4 4.3 8.0 0.1 2.7 3 0 0 3 3 3 0 WW domain-binding protein 1 BTB PF00651.31 CRG90066.1 - 0.13 12.5 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 BTB/POZ domain Abhydrolase_6 PF12697.7 CRG90067.1 - 2.1e-06 28.5 0.0 3.1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 CRG90067.1 - 6.1e-06 26.0 0.1 2.3e-05 24.1 0.0 1.8 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 CRG90067.1 - 0.00013 21.7 0.2 0.46 10.1 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG90067.1 - 0.00037 20.0 0.6 0.6 9.5 0.0 2.4 2 1 0 2 2 2 2 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 CRG90067.1 - 0.0037 16.6 0.0 0.062 12.6 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Med8 PF10232.9 CRG90068.1 - 3.3e-63 213.4 1.0 3.9e-63 213.2 1.0 1.0 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 MPP6 PF10175.9 CRG90068.1 - 0.049 14.1 1.0 0.077 13.5 1.0 1.2 1 0 0 1 1 1 0 M-phase phosphoprotein 6 Prefoldin_2 PF01920.20 CRG90068.1 - 0.27 11.2 2.4 28 4.7 0.6 2.9 3 0 0 3 3 3 0 Prefoldin subunit DNA_pol_phi PF04931.13 CRG90068.1 - 0.63 8.1 5.5 1.1 7.2 5.5 1.4 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 CRG90068.1 - 0.71 10.3 7.3 1.6 9.1 7.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sigma70_ner PF04546.13 CRG90068.1 - 0.88 9.4 6.5 0.65 9.9 4.6 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region NOA36 PF06524.12 CRG90068.1 - 1 8.6 3.6 1.3 8.2 3.6 1.1 1 0 0 1 1 1 0 NOA36 protein PQ-loop PF04193.14 CRG90069.1 - 3e-21 75.0 5.7 1.1e-10 41.2 1.3 2.6 2 0 0 2 2 2 2 PQ loop repeat UbiA PF01040.18 CRG90070.1 - 4.5e-56 190.0 15.8 4.5e-56 190.0 15.8 1.4 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF3336 PF11815.8 CRG90071.1 - 1.2e-34 119.0 0.1 2.1e-34 118.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 CRG90071.1 - 1.9e-18 67.4 0.2 9.5e-18 65.1 0.0 2.3 3 0 0 3 3 3 1 Patatin-like phospholipase Peptidase_S51 PF03575.17 CRG90071.1 - 0.15 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase family S51 Sorting_nexin PF03700.13 CRG90071.1 - 3.9 8.1 7.1 2.2 8.8 4.5 1.8 1 1 1 2 2 2 0 Sorting nexin, N-terminal domain Lipid_DES PF08557.10 CRG90072.1 - 0.11 12.1 1.8 0.38 10.3 0.1 2.6 2 1 1 3 3 3 0 Sphingolipid Delta4-desaturase (DES) Pkinase PF00069.25 CRG90073.1 - 8.4e-31 107.3 0.0 8.6e-30 104.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG90073.1 - 5.5e-12 45.5 0.0 7.2e-05 22.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 CRG90073.1 - 0.13 11.0 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase PMI_typeI PF01238.21 CRG90074.1 - 6.7e-67 226.3 0.0 1e-65 222.4 0.0 2.1 1 1 0 1 1 1 1 Phosphomannose isomerase type I NB-ARC PF00931.22 CRG90074.1 - 7.1e-11 41.8 0.0 1.5e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain PNP_UDP_1 PF01048.20 CRG90074.1 - 1.3e-07 31.1 0.0 3e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG90074.1 - 0.00022 21.2 0.0 0.00047 20.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG90074.1 - 0.00025 21.5 0.2 0.005 17.2 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain Trp_oprn_chp PF09534.10 CRG90076.1 - 0.0002 21.2 0.1 0.00069 19.5 0.1 1.9 2 0 0 2 2 2 1 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SKG6 PF08693.10 CRG90076.1 - 0.00087 18.6 2.1 0.0018 17.6 2.1 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Insulin_TMD PF17870.1 CRG90076.1 - 0.0043 17.1 1.4 0.0082 16.2 1.4 1.3 1 0 0 1 1 1 1 Insulin receptor trans-membrane segment SepZ PF06066.11 CRG90076.1 - 0.014 15.6 2.1 0.014 15.6 2.1 1.7 1 1 1 2 2 2 0 SepZ Mid2 PF04478.12 CRG90076.1 - 0.063 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Ni_hydr_CYTB PF01292.20 CRG90076.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 EphA2_TM PF14575.6 CRG90076.1 - 0.17 12.8 0.6 0.66 10.9 0.7 2.0 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TT_ORF1 PF02956.14 CRG90076.1 - 8.1 5.0 8.8 11 4.6 8.8 1.1 1 0 0 1 1 1 0 TT viral orf 1 YL1 PF05764.13 CRG90077.1 - 3.2 7.8 13.9 0.79 9.8 10.0 1.7 1 1 1 2 2 2 0 YL1 nuclear protein XRCC4 PF06632.12 CRG90077.1 - 4.2 6.1 9.7 7.4 5.3 9.7 1.3 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Peptidase_S64 PF08192.11 CRG90077.1 - 4.8 5.5 10.2 6.4 5.1 10.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 TMEM154 PF15102.6 CRG90078.1 - 0.019 14.8 1.0 0.069 13.0 0.0 2.3 3 0 0 3 3 3 0 TMEM154 protein family DUF4064 PF13273.6 CRG90078.1 - 0.062 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DUF2569 PF10754.9 CRG90078.1 - 0.085 13.3 0.1 0.15 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DUF1180 PF06679.12 CRG90078.1 - 0.8 10.1 2.4 1.1 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Pkinase PF00069.25 CRG90079.1 - 0.0018 17.7 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 CRG90079.1 - 0.014 15.3 0.2 0.038 13.9 0.1 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Filament PF00038.21 CRG90080.1 - 0.00025 20.7 5.3 0.00025 20.7 5.3 2.5 2 1 1 3 3 3 1 Intermediate filament protein Seryl_tRNA_N PF02403.22 CRG90080.1 - 0.0047 17.1 13.9 0.6 10.4 5.2 3.8 2 1 0 3 3 3 2 Seryl-tRNA synthetase N-terminal domain CLZ PF16526.5 CRG90080.1 - 0.017 15.5 1.9 0.017 15.5 1.9 3.5 4 1 0 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Med9 PF07544.13 CRG90080.1 - 0.02 15.0 3.9 0.02 15.0 3.9 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 FlaC_arch PF05377.11 CRG90080.1 - 0.051 14.0 0.9 26 5.3 0.1 3.5 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) COG5 PF10392.9 CRG90080.1 - 0.073 13.2 2.4 4.5 7.5 1.4 2.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DivIVA PF05103.13 CRG90080.1 - 0.35 11.0 5.3 0.2 11.7 1.9 2.4 2 0 0 2 2 2 0 DivIVA protein GAS PF13851.6 CRG90080.1 - 0.4 10.0 14.3 0.32 10.3 7.0 2.7 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spc24 PF08286.11 CRG90080.1 - 0.43 10.8 7.1 1.2 9.5 1.8 3.1 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 Rho_Binding PF08912.11 CRG90080.1 - 1.2 10.0 5.7 2 9.3 0.2 2.9 2 0 0 2 2 2 0 Rho Binding ADIP PF11559.8 CRG90080.1 - 1.3 9.1 10.1 6 6.9 0.3 2.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Striatin PF08232.12 CRG90080.1 - 1.8 9.1 17.6 22 5.6 1.4 3.3 2 1 0 2 2 2 0 Striatin family AAA_13 PF13166.6 CRG90080.1 - 2.2 6.8 9.0 0.84 8.2 4.8 2.0 1 1 1 2 2 2 0 AAA domain CENP-H PF05837.12 CRG90080.1 - 2.6 8.5 15.2 1.7 9.1 5.0 3.4 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Uso1_p115_C PF04871.13 CRG90080.1 - 3.7 7.9 14.3 0.45 10.9 5.0 3.2 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spc7 PF08317.11 CRG90080.1 - 5.7 5.7 13.1 2.9 6.7 7.1 2.4 1 1 0 2 2 2 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 CRG90080.1 - 7.7 6.6 15.1 8.8 6.4 4.9 3.1 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein RPN2_C PF18004.1 CRG90081.1 - 3.6e-55 186.2 9.0 8.8e-55 185.0 9.0 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 CRG90081.1 - 4.5e-35 118.3 29.2 7.5e-10 38.7 0.0 9.4 11 0 0 11 11 11 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 CRG90081.1 - 2.7e-22 78.9 0.1 2.7e-15 56.5 0.0 5.2 4 1 3 7 7 7 3 HEAT repeats HEAT PF02985.22 CRG90081.1 - 3.4e-05 23.7 2.2 4 7.9 0.0 5.9 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 CRG90081.1 - 0.00033 21.1 0.1 0.0012 19.3 0.1 4.7 5 2 2 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 CRG90081.1 - 0.00085 19.4 0.0 0.53 10.3 0.0 3.0 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 GCIP PF13324.6 CRG90081.1 - 0.026 14.1 0.4 0.055 13.1 0.4 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting HEAT_PBS PF03130.16 CRG90081.1 - 0.15 12.8 2.9 1 10.2 0.0 3.9 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Acyl-CoA_dh_1 PF00441.24 CRG90082.1 - 9.3e-43 146.0 0.3 1.3e-42 145.5 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CRG90082.1 - 1.8e-22 79.3 0.1 3e-22 78.6 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CRG90082.1 - 7.9e-20 71.6 0.0 2.1e-19 70.3 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Cyt-b5 PF00173.28 CRG90082.1 - 2.9e-18 65.8 0.3 5.5e-18 64.9 0.3 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.11 CRG90082.1 - 2.7e-11 43.9 0.0 4.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Spt5-NGN PF03439.13 CRG90083.1 - 1.4e-22 79.4 0.0 2.5e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section CTD PF12815.7 CRG90083.1 - 5.2e-21 75.0 35.9 6.2e-18 65.1 22.1 3.8 1 1 2 3 3 3 3 Spt5 C-terminal nonapeptide repeat binding Spt4 Spt5_N PF11942.8 CRG90083.1 - 4.4e-17 62.9 7.8 4.4e-17 62.9 7.8 3.7 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 CRG90083.1 - 1.4e-11 43.9 11.6 0.0006 19.7 0.0 4.6 4 0 0 4 4 4 3 KOW motif NAD_binding_4 PF07993.12 CRG90083.1 - 0.012 14.8 0.2 0.15 11.2 0.0 2.4 2 0 0 2 2 2 0 Male sterility protein DUF3912 PF13051.6 CRG90083.1 - 0.051 13.8 2.4 3.1 8.1 0.2 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3912) MDM1 PF15501.6 CRG90083.1 - 4.9 6.2 10.6 8.3 5.4 10.6 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 SDA1 PF05285.12 CRG90083.1 - 6.3 6.1 28.6 13 5.1 28.6 1.5 1 0 0 1 1 1 0 SDA1 mRNA_triPase PF02940.15 CRG90084.1 - 5e-59 199.7 0.0 7.2e-59 199.2 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain FXMR_C2 PF16098.5 CRG90084.1 - 2.2 8.8 5.0 3.8 8.1 2.2 2.4 2 0 0 2 2 2 0 Fragile X-related mental retardation protein C-terminal region 2 Acyl_transf_3 PF01757.22 CRG90085.1 - 4.9e-30 104.8 40.9 2e-29 102.8 40.9 1.8 1 1 0 1 1 1 1 Acyltransferase family WD40 PF00400.32 CRG90086.1 - 3.6e-13 49.8 12.8 1.1e-05 26.0 0.1 6.3 6 0 0 6 6 6 3 WD domain, G-beta repeat CTP_transf_like PF01467.26 CRG90087.1 - 3.5e-06 27.3 0.1 1e-05 25.8 0.1 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 CRG90087.1 - 0.048 13.6 0.2 0.098 12.5 0.2 1.5 1 0 0 1 1 1 0 FAD synthetase Methyltransf_PK PF05891.12 CRG90088.1 - 2.7e-74 249.4 0.0 4.6e-74 248.6 0.0 1.4 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.6 CRG90088.1 - 3.7e-05 23.6 0.0 0.0001 22.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90088.1 - 0.00053 20.6 0.0 0.0018 18.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain DUF4207 PF13904.6 CRG90088.1 - 0.0078 15.9 8.3 0.015 15.0 8.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4207) Methyltransf_11 PF08241.12 CRG90088.1 - 0.017 15.7 0.0 0.055 14.1 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_S15 PF02129.18 CRG90088.1 - 0.024 14.2 0.5 0.047 13.3 0.5 1.4 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) EVE PF01878.18 CRG90089.1 - 3e-48 163.5 0.1 5.9e-48 162.6 0.1 1.5 1 0 0 1 1 1 1 EVE domain MFS_1 PF07690.16 CRG90090.1 - 1e-39 136.5 39.6 1.9e-39 135.6 32.0 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90090.1 - 1.3e-05 24.3 11.8 1.3e-05 24.3 11.8 2.7 2 2 0 2 2 2 1 Sugar (and other) transporter AhpC-TSA PF00578.21 CRG90091.1 - 1.7e-29 102.2 0.0 2.8e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 CRG90091.1 - 9.1e-13 48.2 0.0 1.3e-12 47.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 CRG90091.1 - 5.8e-12 45.3 0.5 9.8e-12 44.5 0.5 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Kelch_4 PF13418.6 CRG90092.1 - 2.2e-20 72.4 1.4 2.1e-07 30.8 0.1 5.1 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 CRG90092.1 - 5.7e-19 67.9 5.5 1.1e-10 41.5 0.0 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 CRG90092.1 - 6.5e-15 54.7 2.0 1.6e-05 24.8 0.2 4.2 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 CRG90092.1 - 3.5e-14 52.5 6.0 0.0029 17.8 0.0 5.4 3 1 1 4 4 4 4 Kelch motif Kelch_1 PF01344.25 CRG90092.1 - 4.3e-13 48.6 0.8 0.011 15.3 0.0 5.0 4 1 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 CRG90092.1 - 6.2e-11 41.8 0.7 0.00032 20.5 0.0 4.5 4 1 0 4 4 4 3 Kelch motif Beta-lactamase PF00144.24 CRG90093.1 - 2.5e-45 155.2 0.0 9.1e-45 153.3 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase Rossmann-like PF10727.9 CRG90093.1 - 0.048 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Rossmann-like domain Peptidase_S11 PF00768.20 CRG90093.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Mac PF12464.8 CRG90094.1 - 3.6e-15 55.9 0.0 7.4e-15 54.9 0.0 1.6 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep PF00132.24 CRG90094.1 - 5.6e-14 51.2 8.0 3e-11 42.6 5.6 2.3 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 CRG90094.1 - 8.5e-13 47.8 9.9 4.7e-10 39.0 5.9 2.4 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase SGL PF08450.12 CRG90095.1 - 2.5e-69 233.6 0.1 3.1e-69 233.3 0.1 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CRG90095.1 - 0.0077 16.4 0.0 0.021 15.0 0.0 1.7 2 0 0 2 2 2 1 Arylesterase Phytase-like PF13449.6 CRG90095.1 - 0.07 13.1 0.0 0.79 9.6 0.0 2.1 1 1 0 2 2 2 0 Esterase-like activity of phytase PQQ PF01011.21 CRG90095.1 - 0.14 12.1 0.9 1.6 8.8 0.2 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat bZIP_2 PF07716.15 CRG90096.1 - 0.029 14.4 8.0 0.064 13.4 8.0 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Bim_N PF06773.11 CRG90096.1 - 0.36 10.5 7.6 6.3 6.6 0.1 3.9 3 0 0 3 3 3 0 Bim protein N-terminus bZIP_1 PF00170.21 CRG90096.1 - 0.61 10.2 6.9 1.3 9.2 6.9 1.5 1 0 0 1 1 1 0 bZIP transcription factor His_Phos_2 PF00328.22 CRG90097.1 - 1.7e-65 221.9 0.0 2e-65 221.6 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Tyrosinase PF00264.20 CRG90099.1 - 1.3e-39 136.8 6.8 1.9e-39 136.2 6.8 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 CRG90099.1 - 1.3e-12 48.4 0.0 2.2e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Tyosinase C-terminal domain MFS_1 PF07690.16 CRG90100.1 - 1.2e-20 73.8 55.2 1.1e-12 47.6 30.5 2.8 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 CRG90101.1 - 2.2e-41 142.0 61.3 3.5e-40 138.0 57.7 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90101.1 - 3.4e-14 52.6 26.1 1.7e-11 43.7 9.0 2.7 2 1 0 2 2 2 2 Sugar (and other) transporter DIT1_PvcA PF05141.12 CRG90102.1 - 1.2e-92 310.3 0.0 2e-92 309.6 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein AMP-binding PF00501.28 CRG90102.1 - 2.6e-26 92.2 0.0 4e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Transferase PF02458.15 CRG90102.1 - 5.9e-07 28.5 0.0 0.086 11.5 0.0 3.2 3 0 0 3 3 3 3 Transferase family PP-binding PF00550.25 CRG90102.1 - 4.7e-05 23.7 0.0 0.0001 22.6 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ribophorin_II PF05817.14 CRG90104.1 - 1e-27 97.0 0.2 1.3e-27 96.7 0.2 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II MarR_2 PF12802.7 CRG90105.1 - 0.033 14.1 0.0 0.074 13.0 0.0 1.6 1 0 0 1 1 1 0 MarR family Glyco_hydro_35 PF01301.19 CRG90106.1 - 6.3e-85 285.6 1.2 7.9e-85 285.3 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 CRG90106.1 - 0.00032 21.3 0.3 0.0093 16.5 0.0 3.1 3 0 0 3 3 3 1 Beta-galactosidase jelly roll domain Cellulase PF00150.18 CRG90106.1 - 0.0008 18.9 0.3 0.0016 18.0 0.3 1.5 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_14 PF01373.17 CRG90106.1 - 0.04 12.9 1.4 0.32 9.9 0.1 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 14 Sulfatase PF00884.23 CRG90107.1 - 1.3e-21 77.3 0.1 2.6e-21 76.3 0.1 1.4 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CRG90107.1 - 5.8e-07 29.4 0.0 9.1e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CRG90107.1 - 0.0019 16.9 0.0 0.0031 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 CRG90107.1 - 0.0076 15.6 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily adh_short_C2 PF13561.6 CRG90108.1 - 4e-55 186.9 0.9 4.8e-55 186.7 0.9 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG90108.1 - 5.1e-44 150.1 2.5 6.9e-44 149.6 2.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG90108.1 - 1.1e-13 51.5 0.9 1.6e-13 50.9 0.9 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG90108.1 - 0.028 13.9 0.1 0.041 13.4 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Alk_phosphatase PF00245.20 CRG90108.1 - 0.05 12.5 0.2 0.068 12.1 0.2 1.2 1 0 0 1 1 1 0 Alkaline phosphatase DUF3277 PF11681.8 CRG90108.1 - 0.051 13.5 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3277) p450 PF00067.22 CRG90109.1 - 9.7e-34 116.9 0.0 2.9e-33 115.3 0.0 1.6 1 1 0 1 1 1 1 Cytochrome P450 PLA2_B PF01735.18 CRG90110.1 - 9.1e-189 627.9 4.2 1.1e-188 627.7 4.2 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain DAHP_synth_2 PF01474.16 CRG90112.1 - 2e-199 662.6 0.0 2.3e-199 662.4 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family F-box-like PF12937.7 CRG90113.1 - 0.00022 21.0 0.2 0.0005 19.9 0.2 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG90113.1 - 0.023 14.6 0.8 0.082 12.8 0.8 2.0 1 1 0 1 1 1 0 F-box domain HTH_IclR PF09339.10 CRG90113.1 - 0.072 12.9 0.5 1.6 8.6 0.1 2.3 2 0 0 2 2 2 0 IclR helix-turn-helix domain UBA_4 PF14555.6 CRG90114.1 - 0.0072 16.1 0.2 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 UBA-like domain DUF3138 PF11336.8 CRG90114.1 - 0.9 8.1 8.4 1.1 7.8 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) MFS_1 PF07690.16 CRG90115.1 - 4.8e-31 108.0 21.4 4.8e-31 108.0 21.4 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily CysG_dimeriser PF10414.9 CRG90116.1 - 0.034 13.9 2.5 0.069 12.9 0.2 2.4 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region Aldose_epim PF01263.20 CRG90117.1 - 6.8e-43 147.1 0.1 8e-43 146.9 0.1 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Glyco_hydro_65C PF03633.15 CRG90117.1 - 0.023 14.6 0.1 0.059 13.3 0.1 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain Rif1_N PF12231.8 CRG90118.1 - 5e-133 443.7 0.3 8.8e-133 442.9 0.3 1.4 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal But2 PF09792.9 CRG90119.1 - 1.5e-53 181.0 0.5 2.9e-53 180.1 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain NGP1NT PF08153.12 CRG90121.1 - 9.7e-51 171.3 0.0 1.6e-50 170.6 0.0 1.4 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 CRG90121.1 - 5.5e-17 61.9 0.0 2.4e-13 50.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG90121.1 - 7.4e-06 25.6 0.0 8.5e-05 22.1 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 CRG90121.1 - 0.00023 21.1 0.0 0.00058 19.8 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase Arf PF00025.21 CRG90121.1 - 0.00056 19.4 0.1 0.12 11.8 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Dynamin_N PF00350.23 CRG90121.1 - 0.0067 16.5 1.1 0.84 9.7 0.0 3.4 3 1 1 4 4 4 1 Dynamin family GTP_EFTU PF00009.27 CRG90121.1 - 0.011 15.3 0.0 0.97 8.9 0.0 3.0 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Roc PF08477.13 CRG90121.1 - 0.12 12.6 0.1 28 4.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pkinase PF00069.25 CRG90122.1 - 7.6e-38 130.4 0.0 2.6e-37 128.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG90122.1 - 3.2e-27 95.4 0.0 5e-27 94.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG90122.1 - 0.00062 19.2 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CRG90122.1 - 0.015 14.7 0.0 0.04 13.3 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 CRG90122.1 - 0.022 14.7 0.1 0.11 12.4 0.1 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG90122.1 - 0.024 13.4 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pox_ser-thr_kin PF05445.11 CRG90122.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SOG2 PF10428.9 CRG90122.1 - 3.3 6.8 7.3 6.5 5.8 0.0 2.3 2 0 0 2 2 2 0 RAM signalling pathway protein Prefoldin_3 PF13758.6 CRG90123.1 - 2.9e-31 107.4 0.4 9.6e-31 105.8 0.4 2.0 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.7 CRG90123.1 - 2.8e-24 85.8 5.0 3.2e-23 82.4 1.0 5.6 6 1 0 6 6 6 2 Domain of unknown function (DUF3835) Prefoldin PF02996.17 CRG90123.1 - 2.2e-05 24.4 0.3 7.8e-05 22.6 0.3 2.0 1 0 0 1 1 1 1 Prefoldin subunit CHASE3 PF05227.13 CRG90123.1 - 0.061 13.2 0.3 0.061 13.2 0.3 1.9 2 0 0 2 2 2 0 CHASE3 domain DASH_Dad1 PF08649.10 CRG90123.1 - 0.13 12.5 0.2 0.39 10.9 0.2 1.8 1 0 0 1 1 1 0 DASH complex subunit Dad1 Prefoldin_2 PF01920.20 CRG90123.1 - 0.74 9.8 0.0 0.74 9.8 0.0 3.5 4 0 0 4 4 4 0 Prefoldin subunit MAT1 PF06391.13 CRG90124.1 - 3e-41 141.5 9.9 4e-41 141.1 9.9 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 CRG90124.1 - 1.9e-30 104.5 8.8 2.8e-30 103.9 8.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG90124.1 - 8.5e-05 22.4 2.7 0.00019 21.2 2.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG90124.1 - 0.00083 19.6 6.3 0.0015 18.8 6.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 CRG90124.1 - 0.00086 19.1 5.0 0.0015 18.4 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG90124.1 - 0.00091 19.0 4.5 0.0018 18.0 4.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CRG90124.1 - 0.036 13.7 1.3 0.069 12.8 1.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 CRG90124.1 - 0.041 13.8 8.1 0.18 11.8 8.3 1.9 1 1 1 2 2 2 0 zinc-RING finger domain DUF3797 PF12677.7 CRG90124.1 - 0.044 13.7 1.8 0.12 12.3 1.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) zf-RING_4 PF14570.6 CRG90124.1 - 0.52 10.2 8.6 2.5 8.0 8.6 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 CRG90124.1 - 0.53 10.4 7.1 1 9.4 7.1 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 CRG90124.1 - 0.67 9.9 9.6 1.6 8.6 2.7 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CRG90124.1 - 0.99 9.6 4.7 2.4 8.4 4.7 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Cep57_MT_bd PF06657.13 CRG90125.1 - 4.7e-30 103.9 1.4 4.7e-30 103.9 1.4 2.9 2 0 0 2 2 2 1 Centrosome microtubule-binding domain of Cep57 Cep57_CLD_2 PF14197.6 CRG90125.1 - 1.1e-21 76.6 4.6 1.1e-21 76.6 4.6 4.3 4 1 0 4 4 4 1 Centrosome localisation domain of PPC89 MbeD_MobD PF04899.12 CRG90125.1 - 0.48 10.6 6.5 1.3 9.2 0.6 3.0 3 0 0 3 3 3 0 MbeD/MobD like FlaC_arch PF05377.11 CRG90125.1 - 1.5 9.3 8.4 22 5.6 1.4 4.4 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Caskin-tail PF16632.5 CRG90125.1 - 7 7.2 9.3 0.55 10.7 0.5 3.7 4 0 0 4 4 4 0 C-terminal region of Caskin CR6_interact PF10147.9 CRG90126.1 - 0.00041 20.1 5.1 0.00061 19.6 5.1 1.2 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 TMEM51 PF15345.6 CRG90126.1 - 0.047 13.5 0.1 0.047 13.5 0.1 2.8 1 1 2 3 3 3 0 Transmembrane protein 51 VEGFR-2_TMD PF17988.1 CRG90126.1 - 4.4 6.8 5.6 7.1 6.2 5.6 1.3 1 0 0 1 1 1 0 VEGFR-2 Transmembrane domain ABC_membrane PF00664.23 CRG90127.1 - 7.2e-78 262.0 36.3 9.9e-40 136.9 7.5 2.4 3 0 0 3 3 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG90127.1 - 5.6e-56 188.8 0.0 5.7e-27 94.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG90127.1 - 2.1e-14 53.5 3.9 3.5e-07 29.9 0.0 4.9 5 0 0 5 5 5 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 CRG90127.1 - 6.5e-09 36.4 2.0 0.00056 20.3 0.2 3.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CRG90127.1 - 5.5e-08 32.6 1.1 0.16 11.5 0.0 4.3 4 0 0 4 4 4 2 AAA domain AAA_21 PF13304.6 CRG90127.1 - 1.2e-07 31.8 1.2 2.1 8.1 0.0 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CRG90127.1 - 1.5e-07 31.5 0.3 0.0046 16.9 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 CRG90127.1 - 8.2e-07 29.4 3.3 0.048 13.9 0.7 4.2 3 1 0 3 3 3 2 AAA domain AAA_29 PF13555.6 CRG90127.1 - 1.4e-06 27.9 0.5 0.027 14.2 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CRG90127.1 - 8.1e-06 25.9 0.6 0.019 15.0 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase ABC_ATPase PF09818.9 CRG90127.1 - 5.3e-05 22.2 3.7 0.0044 15.9 0.1 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_7 PF12775.7 CRG90127.1 - 0.0045 16.5 0.4 2.4 7.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 CRG90127.1 - 0.0046 16.2 0.2 1.5 8.0 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin AAA_5 PF07728.14 CRG90127.1 - 0.0054 16.7 1.1 5.1 7.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 CRG90127.1 - 0.0069 15.8 0.0 1.3 8.3 0.0 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family Dynamin_N PF00350.23 CRG90127.1 - 0.0084 16.2 1.8 1.9 8.5 0.2 2.5 2 0 0 2 2 2 1 Dynamin family AAA_33 PF13671.6 CRG90127.1 - 0.0095 16.1 2.3 3.9 7.6 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 CRG90127.1 - 0.012 15.4 5.0 2.8 7.6 0.7 3.7 2 2 0 2 2 2 0 AAA domain NACHT PF05729.12 CRG90127.1 - 0.015 15.3 0.2 11 5.9 0.0 3.3 3 0 0 3 3 2 0 NACHT domain SbcCD_C PF13558.6 CRG90127.1 - 0.018 15.3 0.3 0.98 9.7 0.0 3.2 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit T2SSE PF00437.20 CRG90127.1 - 0.02 13.9 0.0 0.82 8.7 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein RNA_helicase PF00910.22 CRG90127.1 - 0.027 14.9 0.1 3.9 7.9 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 CRG90127.1 - 0.029 13.6 0.3 7 5.8 0.1 2.3 2 0 0 2 2 2 0 NB-ARC domain NTPase_1 PF03266.15 CRG90127.1 - 0.034 14.1 0.4 2.4 8.0 0.1 2.8 2 0 0 2 2 2 0 NTPase cobW PF02492.19 CRG90127.1 - 0.034 13.7 0.3 3.8 7.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 CRG90127.1 - 0.036 13.4 0.3 0.9 8.8 0.0 2.2 2 0 0 2 2 2 0 Septin DUF87 PF01935.17 CRG90127.1 - 0.038 14.1 7.8 0.46 10.5 0.2 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain APS_kinase PF01583.20 CRG90127.1 - 0.039 13.9 0.4 3.5 7.5 0.1 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_23 PF13476.6 CRG90127.1 - 0.041 14.4 0.2 7.4 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 CRG90127.1 - 0.041 14.4 1.6 8.2 7.0 0.2 2.9 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 CRG90127.1 - 0.052 12.7 0.0 3.6 6.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TniB PF05621.11 CRG90127.1 - 0.072 12.5 2.3 25 4.2 0.0 3.9 4 0 0 4 4 4 0 Bacterial TniB protein DUF3987 PF13148.6 CRG90127.1 - 0.085 11.9 0.2 8.1 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Sigma54_activat PF00158.26 CRG90127.1 - 0.085 12.6 0.0 7.3 6.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 CRG90127.1 - 0.11 11.8 0.3 3.6 6.9 0.0 2.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 CRG90127.1 - 0.13 11.9 0.6 16 5.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain Ploopntkinase3 PF18751.1 CRG90127.1 - 0.16 11.9 0.2 13 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 DLIC PF05783.11 CRG90127.1 - 0.19 10.5 0.2 14 4.4 0.0 2.2 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) ATPase PF06745.13 CRG90127.1 - 0.62 9.4 3.0 14 5.0 0.0 3.2 3 0 0 3 3 3 0 KaiC Polysacc_synt_4 PF04669.13 CRG90128.1 - 2.6e-21 76.1 0.9 1.1e-19 70.8 0.9 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis AChE_tetra PF08674.10 CRG90128.1 - 0.098 12.4 2.5 0.25 11.0 2.5 1.7 1 0 0 1 1 1 0 Acetylcholinesterase tetramerisation domain Ric8 PF10165.9 CRG90129.1 - 1.1e-117 393.9 0.0 1.5e-117 393.4 0.0 1.2 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn adh_short PF00106.25 CRG90130.1 - 7.1e-37 126.8 0.0 3.8e-27 95.0 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90130.1 - 5.8e-23 81.7 0.1 7.2e-16 58.5 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90130.1 - 5.8e-12 45.9 0.0 8e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG90130.1 - 0.0034 16.6 0.0 0.0046 16.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 CRG90130.1 - 0.03 13.8 0.0 0.058 12.8 0.0 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 CRG90131.1 - 4.3e-23 81.9 0.0 6.3e-23 81.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90131.1 - 1.7e-10 41.5 0.0 4.5e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG90131.1 - 2.2e-07 31.5 0.0 1.5e-06 28.9 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90131.1 - 8e-07 29.6 0.0 2.1e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90131.1 - 8.6e-06 25.6 0.0 0.00011 22.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CRG90131.1 - 0.0022 17.8 0.1 0.1 12.3 0.1 2.2 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 CRG90131.1 - 0.015 14.6 0.0 0.083 12.2 0.0 2.1 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family GidB PF02527.15 CRG90131.1 - 0.025 13.9 0.0 0.14 11.5 0.0 1.9 1 1 0 1 1 1 0 rRNA small subunit methyltransferase G FtsJ PF01728.19 CRG90131.1 - 0.03 14.4 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Fungal_trans PF04082.18 CRG90132.1 - 8.3e-12 44.7 0.1 1.6e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mur_ligase_C PF02875.21 CRG90132.1 - 0.0079 16.4 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain Zn_peptidase PF04228.13 CRG90132.1 - 0.052 13.0 0.0 0.082 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative neutral zinc metallopeptidase PAP2 PF01569.21 CRG90133.1 - 1.5e-29 102.4 0.3 4e-29 101.1 0.3 1.7 1 0 0 1 1 1 1 PAP2 superfamily Sulf_transp PF04143.14 CRG90133.1 - 0.05 13.2 0.2 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 Sulphur transport ICE2 PF08426.10 CRG90133.1 - 0.069 12.3 1.4 0.25 10.4 0.3 1.9 2 0 0 2 2 2 0 ICE2 SLATT_1 PF18181.1 CRG90133.1 - 0.077 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 PAP2_3 PF14378.6 CRG90133.1 - 0.14 11.8 3.0 0.65 9.7 3.0 2.1 1 1 0 1 1 1 0 PAP2 superfamily MOSC PF03473.17 CRG90135.1 - 6.1e-30 103.9 0.5 4.4e-29 101.1 0.5 2.1 1 1 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 CRG90135.1 - 5.2e-25 87.7 0.0 1.2e-24 86.5 0.0 1.7 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Aminotran_5 PF00266.19 CRG90135.1 - 3.4e-22 78.9 0.0 4.2e-21 75.3 0.0 2.1 1 1 0 1 1 1 1 Aminotransferase class-V Mitoc_mL59 PF18126.1 CRG90136.1 - 2.2e-47 160.6 9.0 6.9e-47 159.0 9.0 1.8 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 Hid1 PF12722.7 CRG90136.1 - 0.18 9.9 0.9 0.25 9.4 0.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Suf PF05843.14 CRG90137.1 - 0.00047 20.2 9.1 0.0011 19.0 0.2 3.3 2 2 2 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 CRG90137.1 - 0.022 15.6 8.7 1.3 10.0 0.0 6.2 6 2 3 9 9 9 0 Tetratricopeptide repeat zf-CSL PF05207.13 CRG90138.1 - 1.3e-18 66.4 0.2 2.7e-18 65.5 0.2 1.5 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 CRG90138.1 - 9.8e-13 48.0 1.0 5.7e-12 45.6 1.0 2.0 1 1 0 1 1 1 1 DnaJ domain Helo_like_N PF17111.5 CRG90139.1 - 1.9e-79 265.9 7.8 3.2e-70 235.8 0.7 2.1 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins DUF1664 PF07889.12 CRG90139.1 - 0.019 15.0 8.4 9.4 6.3 1.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 CRG90139.1 - 0.048 13.8 6.7 0.15 12.2 0.1 3.3 3 0 0 3 3 3 0 RasGAP C-terminus DUF3280 PF11684.8 CRG90139.1 - 0.1 13.0 1.5 0.12 12.8 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2380) DUF16 PF01519.16 CRG90139.1 - 0.12 12.9 9.6 2.1 8.9 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function DUF16 Leu_zip PF15294.6 CRG90139.1 - 0.18 11.3 7.4 0.024 14.1 2.3 2.0 2 1 0 2 2 2 0 Leucine zipper Apolipoprotein PF01442.18 CRG90139.1 - 0.57 10.0 7.3 2.3 8.0 3.9 2.8 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain Bacillus_HBL PF05791.11 CRG90139.1 - 0.84 9.4 5.5 1.2 9.0 0.5 3.1 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Baculo_PEP_C PF04513.12 CRG90139.1 - 0.91 9.6 7.4 16 5.6 0.3 3.6 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus GAS PF13851.6 CRG90139.1 - 2.3 7.5 11.6 0.18 11.1 2.1 2.8 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding FLYWCH_N PF15423.6 CRG90140.1 - 0.082 13.0 0.2 0.15 12.1 0.2 1.4 1 0 0 1 1 1 0 FLYWCH-type zinc finger-containing protein DUF1149 PF06619.11 CRG90141.1 - 0.0027 18.0 0.0 0.005 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1149) PITH PF06201.13 CRG90142.1 - 2.4e-34 118.8 0.0 4.3e-34 117.9 0.0 1.4 2 0 0 2 2 2 1 PITH domain Thioredoxin PF00085.20 CRG90142.1 - 4.3e-29 100.5 0.0 7.7e-29 99.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 CRG90142.1 - 2.5e-07 30.4 0.0 2.4e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CRG90142.1 - 9.5e-06 26.0 0.3 4.8e-05 23.8 0.3 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 CRG90142.1 - 2.1e-05 24.7 0.0 0.00022 21.5 0.0 2.2 1 1 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 CRG90142.1 - 0.00036 20.3 0.1 0.39 10.4 0.0 2.3 1 1 1 2 2 2 2 Redoxin AhpC-TSA PF00578.21 CRG90142.1 - 0.0013 18.7 0.2 0.17 11.8 0.0 2.3 1 1 1 2 2 2 1 AhpC/TSA family Thioredoxin_9 PF14595.6 CRG90142.1 - 0.0017 18.1 0.0 0.0028 17.4 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 CRG90142.1 - 0.0022 17.9 0.1 0.043 13.8 0.0 2.6 3 0 0 3 3 3 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 CRG90142.1 - 0.031 14.1 0.1 0.052 13.4 0.1 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 CRG90142.1 - 0.036 14.2 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like F-box-like PF12937.7 CRG90143.1 - 2e-06 27.6 0.3 5.6e-06 26.1 0.3 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG90143.1 - 0.0089 15.9 0.7 0.032 14.1 0.2 2.3 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 CRG90143.1 - 0.069 13.0 1.9 0.18 11.7 0.2 2.3 2 0 0 2 2 2 0 F-box Sec34 PF04136.15 CRG90143.1 - 0.079 12.8 0.6 1.5 8.6 0.1 2.6 2 0 0 2 2 2 0 Sec34-like family zf-C2H2 PF00096.26 CRG90145.1 - 1.1e-12 47.7 11.6 2e-06 27.9 0.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG90145.1 - 7.3e-07 29.3 4.1 7.3e-07 29.3 4.1 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG90145.1 - 4.7e-06 27.0 15.2 0.0024 18.6 0.2 3.0 3 0 0 3 3 2 2 C2H2-type zinc finger zf-met PF12874.7 CRG90145.1 - 5.7e-05 23.4 4.9 0.0072 16.7 0.4 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CRG90145.1 - 9.3e-05 22.6 3.8 0.049 13.9 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CRG90145.1 - 0.00024 21.0 9.0 0.0075 16.3 0.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-BED PF02892.15 CRG90145.1 - 0.053 13.6 6.5 0.067 13.2 1.8 2.4 1 1 1 2 2 2 0 BED zinc finger zf_C2H2_ZHX PF18387.1 CRG90145.1 - 0.1 12.2 4.4 3.1 7.5 0.2 2.5 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_3rep PF18868.1 CRG90145.1 - 0.11 13.1 2.1 2.7 8.7 0.4 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 CRG90145.1 - 1.3 8.8 7.2 9.6 6.1 0.0 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 CRG90145.1 - 2.3 8.4 4.1 10 6.3 0.6 2.5 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2HE PF16278.5 CRG90145.1 - 6.9 7.2 10.6 5.2 7.6 0.7 3.0 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Diphthami_syn_2 PF01902.17 CRG90146.1 - 1.6e-17 63.7 0.0 1.8e-10 40.7 0.0 2.9 1 1 1 2 2 2 2 Diphthamide synthase Ribonuc_L-PSP PF01042.21 CRG90146.1 - 4.7e-12 46.0 0.0 3.3e-06 27.1 0.0 3.5 3 0 0 3 3 3 2 Endoribonuclease L-PSP DUF3543 PF12063.8 CRG90148.1 - 1.1e-96 323.1 0.0 1.6e-96 322.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 CRG90148.1 - 2e-62 211.0 0.0 3.2e-62 210.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG90148.1 - 1.7e-43 148.8 0.0 3e-43 148.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AA_permease_2 PF13520.6 CRG90149.1 - 1.1e-87 294.6 37.5 1.5e-87 294.2 37.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG90149.1 - 2.1e-19 69.5 33.8 3.2e-19 68.9 33.6 1.3 1 1 0 1 1 1 1 Amino acid permease ERAP1_C PF11838.8 CRG90150.1 - 6.3e-90 301.9 2.1 3.5e-89 299.5 0.3 2.4 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 CRG90150.1 - 4.7e-84 281.3 1.6 6.9e-84 280.8 1.6 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 CRG90150.1 - 2.2e-52 178.0 1.7 2.8e-52 177.6 0.7 1.7 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain NACHT PF05729.12 CRG90151.1 - 1.3e-14 54.4 0.1 6.8e-14 52.1 0.1 2.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG90151.1 - 2e-07 31.6 0.2 2e-07 31.6 0.2 3.3 4 0 0 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 CRG90151.1 - 3.5e-07 30.6 2.2 6.5e-05 23.2 0.0 4.2 4 0 0 4 4 4 1 AAA domain SesA PF17107.5 CRG90151.1 - 0.00053 20.2 6.3 0.0099 16.1 0.4 2.8 2 0 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases ABC_tran PF00005.27 CRG90151.1 - 0.0054 17.2 1.6 0.13 12.8 0.1 2.9 3 0 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 CRG90151.1 - 0.024 14.5 0.0 0.057 13.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Viral_helicase1 PF01443.18 CRG90151.1 - 0.051 13.3 0.0 0.095 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.6 CRG90151.1 - 0.092 12.5 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 CRG90151.1 - 0.15 11.8 2.8 0.16 11.7 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 CRG90151.1 - 0.15 12.6 0.7 6.5 7.3 0.0 3.1 2 0 0 2 2 2 0 AAA domain Ribonuc_2-5A PF06479.12 CRG90151.1 - 0.19 11.9 9.7 2.3 8.4 0.4 2.7 2 0 0 2 2 2 0 Ribonuclease 2-5A Ploopntkinase1 PF18748.1 CRG90151.1 - 0.2 11.2 0.0 0.46 10.0 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 RyR PF02026.16 CRG90151.1 - 0.54 10.5 4.4 0.53 10.5 1.5 2.3 2 0 0 2 2 2 0 RyR domain DUF148 PF02520.17 CRG90151.1 - 0.55 10.4 4.7 0.98 9.6 2.0 2.8 3 0 0 3 3 3 0 Domain of unknown function DUF148 COG2 PF06148.11 CRG90151.1 - 0.79 9.8 16.2 0.023 14.8 2.6 4.4 4 1 1 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA_23 PF13476.6 CRG90151.1 - 1.1 9.7 8.7 8 6.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain Ntox1 PF15500.6 CRG90151.1 - 3.8 7.9 4.3 1.4 9.3 0.1 2.3 2 0 0 2 2 2 0 Putative RNase-like toxin, toxin_1 p450 PF00067.22 CRG90152.1 - 1.8e-67 228.1 0.0 2.1e-67 227.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 TRI5 PF06330.11 CRG90153.1 - 3.8e-30 105.0 0.0 5e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) KLRAQ PF10205.9 CRG90154.1 - 0.00047 20.3 1.7 0.00086 19.5 1.7 1.3 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein DHR10 PF18595.1 CRG90154.1 - 0.33 11.0 2.6 0.5 10.4 2.6 1.2 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain TBCC_N PF16752.5 CRG90155.1 - 0.011 16.2 0.8 0.011 16.2 0.8 1.6 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain ArfGap PF01412.18 CRG90156.1 - 1.1e-37 128.7 0.1 2e-37 127.8 0.1 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf GATA PF00320.27 CRG90156.1 - 1.4 8.6 4.0 2.6 7.7 4.0 1.5 1 0 0 1 1 1 0 GATA zinc finger Glyco_transf_22 PF03901.17 CRG90157.1 - 3.6e-77 260.4 20.7 4.9e-77 259.9 20.7 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family DUF697 PF05128.12 CRG90157.1 - 0.41 10.4 2.7 20 4.9 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF697) Aminotran_3 PF00202.21 CRG90158.1 - 1e-117 393.2 0.0 1.2e-117 393.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 CRG90158.1 - 0.074 12.2 0.0 0.14 11.3 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class I and II ABC_membrane PF00664.23 CRG90159.1 - 2.8e-57 194.5 39.6 3.9e-35 121.8 17.3 3.2 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 CRG90159.1 - 3.3e-48 163.7 0.0 3.5e-27 95.6 0.1 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG90159.1 - 5.8e-06 25.9 1.2 1.6 8.1 0.0 3.8 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 CRG90159.1 - 8.2e-06 25.2 0.0 0.0014 17.9 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_21 PF13304.6 CRG90159.1 - 2.4e-05 24.3 0.8 1.5 8.6 0.1 3.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CRG90159.1 - 2.9e-05 24.1 1.9 0.019 15.0 0.2 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CRG90159.1 - 6.5e-05 22.6 1.2 0.41 10.4 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG90159.1 - 7.6e-05 22.7 0.5 0.074 13.0 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CRG90159.1 - 0.00014 22.4 0.1 0.32 11.4 0.1 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG90159.1 - 0.00027 21.4 0.3 0.58 10.5 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain Dynamin_N PF00350.23 CRG90159.1 - 0.0022 18.1 4.1 0.39 10.8 0.1 3.6 4 0 0 4 4 3 1 Dynamin family DUF87 PF01935.17 CRG90159.1 - 0.0068 16.5 1.3 0.24 11.5 0.1 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_22 PF13401.6 CRG90159.1 - 0.0077 16.5 1.5 4.8 7.5 0.0 3.5 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CRG90159.1 - 0.017 14.6 0.1 5.3 6.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 CRG90159.1 - 0.025 14.3 1.5 6.7 6.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 CRG90159.1 - 0.032 13.9 0.0 1.3 8.7 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 CRG90159.1 - 0.033 14.7 0.1 6.9 7.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain Roc PF08477.13 CRG90159.1 - 0.048 13.9 0.1 18 5.6 0.1 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CRG90159.1 - 0.091 12.5 0.7 15 5.3 0.1 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ubiquitin_4 PF18036.1 CRG90159.1 - 0.12 12.4 0.2 0.31 11.1 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain AAA_15 PF13175.6 CRG90159.1 - 0.17 11.5 3.9 3.1 7.4 0.1 2.8 2 1 1 3 3 3 0 AAA ATPase domain AAA_28 PF13521.6 CRG90159.1 - 0.2 11.9 2.4 0.72 10.1 0.1 2.7 3 0 0 3 3 2 0 AAA domain TsaE PF02367.17 CRG90159.1 - 2.2 8.3 4.2 5.4 7.0 0.0 3.1 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Orf78 PF06024.12 CRG90159.1 - 2.7 8.4 7.6 22 5.4 1.1 3.9 4 0 0 4 4 4 0 Orf78 (ac78) SHR3_chaperone PF08229.11 CRG90164.1 - 4.4e-79 263.9 0.0 5.2e-79 263.6 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF5453 PF17534.2 CRG90164.1 - 0.03 14.3 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5453) Trp_oprn_chp PF09534.10 CRG90164.1 - 0.083 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) HlyIII PF03006.20 CRG90164.1 - 0.097 12.4 0.6 0.16 11.7 0.6 1.3 1 0 0 1 1 1 0 Haemolysin-III related TcpE PF12648.7 CRG90164.1 - 0.36 11.4 1.8 1.4 9.5 1.8 2.0 1 1 0 1 1 1 0 TcpE family Arrestin_N PF00339.29 CRG90165.1 - 1.2e-16 61.1 0.0 1.5e-15 57.5 0.0 2.6 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 CRG90165.1 - 5.8e-09 36.5 0.5 2.3e-05 24.9 0.0 3.4 2 1 1 3 3 3 2 Arrestin (or S-antigen), C-terminal domain UAF_Rrn10 PF05234.11 CRG90167.1 - 0.0071 16.6 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 UAF complex subunit Rrn10 Mnd1 PF03962.15 CRG90168.1 - 1e-17 64.2 0.1 1.9e-17 63.2 0.1 1.5 1 0 0 1 1 1 1 Mnd1 HTH domain ALIX_LYPXL_bnd PF13949.6 CRG90168.1 - 0.0074 15.6 0.8 0.011 15.0 0.8 1.3 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Dynamitin PF04912.14 CRG90168.1 - 0.014 14.8 0.3 0.017 14.5 0.3 1.1 1 0 0 1 1 1 0 Dynamitin LegC3_N PF18654.1 CRG90168.1 - 0.048 12.9 0.4 0.074 12.3 0.4 1.3 1 0 0 1 1 1 0 LegC3 N-terminal coiled-coil domain Spc24 PF08286.11 CRG90168.1 - 0.064 13.5 2.0 3.1 8.1 0.0 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 CRG90168.1 - 0.22 12.0 8.6 4.1 7.9 3.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region HALZ PF02183.18 CRG90168.1 - 1 9.7 4.8 1.6 9.0 0.4 2.3 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF4164 PF13747.6 CRG90168.1 - 1.3 9.4 7.6 2.7 8.3 3.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Prefoldin_2 PF01920.20 CRG90168.1 - 2.4 8.1 8.0 13 5.8 0.2 2.4 2 0 0 2 2 2 0 Prefoldin subunit Fungal_trans_2 PF11951.8 CRG90169.1 - 1.4e-86 290.8 0.0 1.7e-86 290.5 0.0 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90169.1 - 2.4e-07 30.8 6.9 4e-07 30.1 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAM_2 PF07647.17 CRG90170.1 - 3.1e-12 46.4 0.0 5.4e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CRG90170.1 - 1.6e-10 41.3 0.1 4e-10 40.0 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 CRG90170.1 - 8.4e-08 32.7 0.1 3.1e-07 30.8 0.1 2.0 1 1 0 1 1 1 1 PH domain SAM_3 PF18016.1 CRG90170.1 - 9e-05 22.2 0.0 0.00024 20.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 CRG90170.1 - 0.0018 18.5 0.1 0.0035 17.5 0.1 1.4 1 0 0 1 1 1 1 Ste50p, sterile alpha motif SAM_PNT PF02198.16 CRG90170.1 - 0.18 11.8 0.0 0.41 10.6 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain APG5 PF04106.12 CRG90171.1 - 9.9e-61 205.2 0.0 1.3e-60 204.9 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 PKS_DE PF18369.1 CRG90171.1 - 0.063 13.9 0.0 0.44 11.2 0.0 2.3 2 0 0 2 2 2 0 Polyketide synthase dimerisation element domain Abhydrolase_1 PF00561.20 CRG90172.1 - 3.2e-11 43.4 2.4 1e-09 38.4 1.4 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG90172.1 - 1.7e-10 40.6 0.0 8.3e-10 38.3 0.0 2.1 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG90172.1 - 8.2e-10 39.7 0.2 1.2e-09 39.1 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CRG90172.1 - 0.0014 18.2 0.0 0.62 9.6 0.0 2.5 2 0 0 2 2 2 2 Dienelactone hydrolase family Esterase PF00756.20 CRG90172.1 - 0.0051 16.5 0.0 0.015 14.9 0.0 1.6 1 1 0 1 1 1 1 Putative esterase FSH1 PF03959.13 CRG90172.1 - 0.045 13.4 0.1 3 7.4 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase (FSH1) adh_short PF00106.25 CRG90173.1 - 5.1e-39 133.8 0.0 1.2e-38 132.6 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90173.1 - 1.2e-23 83.9 0.0 2.7e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90173.1 - 3.1e-06 27.2 0.0 6.6e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG90173.1 - 0.0083 15.5 0.0 0.02 14.3 0.0 1.6 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Helo_like_N PF17111.5 CRG90174.1 - 0.00094 18.6 3.0 0.00094 18.6 3.0 1.8 2 0 0 2 2 2 1 Fungal N-terminal domain of STAND proteins DUF962 PF06127.11 CRG90174.1 - 0.19 11.8 0.0 0.5 10.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF962) KIP1 PF07765.12 CRG90174.1 - 0.25 11.5 5.8 1.6 8.9 2.2 3.4 3 0 0 3 3 3 0 KIP1-like protein DUF2960 PF11173.8 CRG90174.1 - 0.46 11.0 2.1 0.74 10.3 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2960) ANAPC4_WD40 PF12894.7 CRG90175.1 - 4.3e-07 30.1 0.0 0.0066 16.7 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain YL1 PF05764.13 CRG90175.1 - 0.0026 17.9 3.2 0.0039 17.3 3.2 1.2 1 0 0 1 1 1 1 YL1 nuclear protein WD40 PF00400.32 CRG90175.1 - 0.022 15.6 2.4 5.7 8.0 0.0 4.4 4 0 0 4 4 4 0 WD domain, G-beta repeat CDC45 PF02724.14 CRG90175.1 - 0.14 10.4 5.5 0.19 10.0 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 CRG90175.1 - 0.29 9.7 11.3 0.42 9.2 11.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RRN3 PF05327.11 CRG90175.1 - 0.54 8.7 2.4 0.74 8.3 2.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SURF2 PF05477.11 CRG90175.1 - 3.5 7.3 8.1 5.3 6.7 8.1 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) NOA36 PF06524.12 CRG90175.1 - 4 6.7 10.0 6.2 6.0 10.0 1.2 1 0 0 1 1 1 0 NOA36 protein SGT1 PF07093.11 CRG90175.1 - 8.5 4.7 6.8 11 4.4 6.8 1.1 1 0 0 1 1 1 0 SGT1 protein Fe-ADH PF00465.19 CRG90176.1 - 1.7e-77 260.7 0.2 2e-77 260.5 0.2 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 CRG90176.1 - 1.1e-13 51.5 0.2 1.5e-13 51.0 0.2 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Pdase_M17_N2 PF18295.1 CRG90176.1 - 0.12 12.6 0.1 6.3 7.1 0.0 3.0 3 0 0 3 3 3 0 M17 aminopeptidase N-terminal domain 2 UPF0261 PF06792.11 CRG90176.1 - 0.14 11.1 0.4 0.21 10.5 0.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) Diphthamide_syn PF01866.17 CRG90177.1 - 3.9e-87 292.5 0.0 5.4e-86 288.8 0.0 2.0 1 1 0 1 1 1 1 Putative diphthamide synthesis protein PH PF00169.29 CRG90180.1 - 7.8e-12 45.6 0.0 3.2e-11 43.7 0.0 2.0 1 1 0 1 1 1 1 PH domain SH3_9 PF14604.6 CRG90180.1 - 1.9e-11 43.6 0.1 3.6e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG90180.1 - 4.1e-10 39.1 0.0 8.3e-10 38.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 CRG90180.1 - 3.4e-08 33.5 0.1 5.6e-08 32.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 CRG90180.1 - 0.00021 20.9 0.1 0.00043 19.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain PH_11 PF15413.6 CRG90180.1 - 0.01 16.2 0.0 0.024 15.1 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain SAM_1 PF00536.30 CRG90180.1 - 0.014 15.9 0.0 0.027 14.9 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH_8 PF15409.6 CRG90180.1 - 0.02 15.1 0.0 0.15 12.4 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DUF3435 PF11917.8 CRG90181.1 - 0.0001 21.4 0.0 0.00012 21.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Aldo_ket_red PF00248.21 CRG90182.1 - 5.3e-68 229.4 0.0 6.6e-68 229.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3425 PF11905.8 CRG90183.1 - 4.5e-21 75.1 0.0 8.6e-21 74.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) AAA_11 PF13086.6 CRG90183.1 - 0.042 13.6 0.2 0.056 13.2 0.2 1.1 1 0 0 1 1 1 0 AAA domain FAD_binding_4 PF01565.23 CRG90184.1 - 3.2e-24 85.2 1.4 7.2e-24 84.1 1.4 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG90184.1 - 0.011 15.8 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 0 Berberine and berberine like zf-MIZ PF02891.20 CRG90185.1 - 1.8e-09 37.2 0.1 3.9e-09 36.1 0.1 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 CRG90185.1 - 0.00014 21.6 0.2 0.00034 20.4 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit PhyH PF05721.13 CRG90186.1 - 1.2e-17 64.9 0.0 1.4e-17 64.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF5102 PF17104.5 CRG90187.1 - 7.4e-110 367.5 2.6 1.4e-109 366.6 2.6 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) Nsp1_C PF05064.13 CRG90188.1 - 1.3e-40 137.8 1.1 1.3e-40 137.8 1.1 1.7 2 0 0 2 2 2 1 Nsp1-like C-terminal region Nucleoporin_FG PF13634.6 CRG90188.1 - 9.5e-06 26.4 170.2 0.0032 18.3 44.0 7.6 1 1 3 4 4 2 2 Nucleoporin FG repeat region ParB PF08775.10 CRG90188.1 - 0.0083 16.6 0.6 0.018 15.5 0.6 1.5 1 0 0 1 1 1 1 ParB family DUF948 PF06103.11 CRG90188.1 - 0.081 13.2 2.3 0.35 11.1 0.4 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 CRG90188.1 - 0.12 12.4 7.6 1.4 8.9 0.2 2.4 1 1 1 2 2 2 0 Laminin Domain II SGT1 PF07093.11 CRG90188.1 - 0.14 10.6 2.9 0.2 10.1 2.9 1.1 1 0 0 1 1 1 0 SGT1 protein DUF1664 PF07889.12 CRG90188.1 - 0.17 11.9 4.8 0.37 10.8 0.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 CRG90188.1 - 0.24 11.9 7.1 0.29 11.7 1.1 2.5 1 1 2 3 3 3 0 Protein of unknown function DUF16 DUF4200 PF13863.6 CRG90188.1 - 0.25 11.7 10.0 0.32 11.4 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) OmpH PF03938.14 CRG90188.1 - 0.5 10.7 9.5 1 9.7 0.9 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) AAA_13 PF13166.6 CRG90188.1 - 0.98 8.0 6.4 0.53 8.9 2.5 1.9 1 1 1 2 2 2 0 AAA domain CK2S PF15011.6 CRG90188.1 - 1.1 9.2 5.3 8.4 6.3 0.7 2.5 2 1 0 2 2 2 0 Casein Kinase 2 substrate EzrA PF06160.12 CRG90188.1 - 1.3 7.1 6.9 0.7 8.0 1.4 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA TACC_C PF05010.14 CRG90188.1 - 1.4 8.7 8.1 11 5.8 7.2 2.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Snapin_Pallidin PF14712.6 CRG90188.1 - 1.9 9.0 5.1 6.2 7.3 0.1 2.4 2 0 0 2 2 2 0 Snapin/Pallidin HIP1_clath_bdg PF16515.5 CRG90188.1 - 2.2 8.9 11.2 2 9.1 0.7 2.9 1 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 IFT57 PF10498.9 CRG90188.1 - 2.8 6.8 11.3 0.3 10.0 3.0 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 CENP-Q PF13094.6 CRG90188.1 - 3.5 7.8 7.2 6.8 6.9 7.2 1.5 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Spc7 PF08317.11 CRG90188.1 - 5.5 5.8 13.6 1.7 7.4 3.9 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 CRG90188.1 - 7.1 7.0 6.7 9 6.7 0.7 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.8 CRG90188.1 - 8.5 5.6 9.8 2.9 7.1 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF2205 PF10224.9 CRG90189.1 - 4.9e-35 119.4 2.4 6.9e-35 118.9 2.4 1.2 1 0 0 1 1 1 1 Short coiled-coil protein DUF3450 PF11932.8 CRG90189.1 - 0.0042 16.4 4.5 0.0054 16.1 4.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) YabA PF06156.13 CRG90189.1 - 0.013 16.1 3.8 0.018 15.7 3.8 1.2 1 0 0 1 1 1 0 Initiation control protein YabA IFT20 PF14931.6 CRG90189.1 - 0.017 15.3 3.0 0.025 14.7 3.0 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Spectrin PF00435.21 CRG90189.1 - 0.025 15.0 1.8 0.038 14.5 1.8 1.2 1 0 0 1 1 1 0 Spectrin repeat CASP_C PF08172.12 CRG90189.1 - 0.048 13.0 4.1 0.073 12.4 4.1 1.3 1 0 0 1 1 1 0 CASP C terminal FlxA PF14282.6 CRG90189.1 - 0.053 13.5 4.7 0.11 12.5 4.7 1.6 1 0 0 1 1 1 0 FlxA-like protein Baculo_PEP_C PF04513.12 CRG90189.1 - 0.058 13.4 0.8 0.087 12.9 0.8 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 CRG90189.1 - 0.063 13.8 0.7 0.095 13.3 0.7 1.3 1 0 0 1 1 1 0 YtxH-like protein Fmp27_WPPW PF10359.9 CRG90189.1 - 0.064 12.1 3.5 0.075 11.9 3.5 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DivIC PF04977.15 CRG90189.1 - 0.073 12.9 2.5 0.12 12.2 2.5 1.3 1 0 0 1 1 1 0 Septum formation initiator HALZ PF02183.18 CRG90189.1 - 0.081 13.2 4.0 0.36 11.1 0.1 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF5320 PF17253.2 CRG90189.1 - 0.11 13.6 3.7 0.32 12.1 2.4 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5320) T3SS_basalb_I PF17001.5 CRG90189.1 - 0.11 13.1 1.7 0.2 12.2 1.7 1.3 1 0 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI FKS1_dom1 PF14288.6 CRG90189.1 - 0.17 12.2 0.4 0.23 11.8 0.4 1.1 1 0 0 1 1 1 0 1,3-beta-glucan synthase subunit FKS1, domain-1 bZIP_1 PF00170.21 CRG90189.1 - 0.18 11.9 4.9 0.4 10.8 4.8 1.7 1 1 1 2 2 2 0 bZIP transcription factor Prefoldin PF02996.17 CRG90189.1 - 0.25 11.3 3.4 0.45 10.4 2.7 1.6 1 1 1 2 2 2 0 Prefoldin subunit XhlA PF10779.9 CRG90189.1 - 0.26 11.5 2.0 0.75 10.1 1.0 1.9 1 1 1 2 2 2 0 Haemolysin XhlA LCD1 PF09798.9 CRG90189.1 - 0.37 9.2 6.9 0.44 9.0 6.9 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein JIP_LZII PF16471.5 CRG90189.1 - 0.49 10.6 4.8 1.3 9.2 2.0 2.1 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II 14-3-3 PF00244.20 CRG90190.1 - 1.1e-105 352.0 5.5 1.3e-105 351.8 5.5 1.0 1 0 0 1 1 1 1 14-3-3 protein Orbi_VP5 PF00901.17 CRG90190.1 - 0.17 10.2 3.1 0.26 9.7 3.1 1.2 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP5 IATP PF04568.12 CRG90191.1 - 3.9e-28 97.8 0.5 4.3e-28 97.6 0.5 1.0 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP Erythro-docking PF09277.11 CRG90191.1 - 0.0041 17.0 0.3 0.039 13.9 0.3 2.3 2 1 0 2 2 2 1 Erythronolide synthase, docking DUF2730 PF10805.8 CRG90191.1 - 0.012 15.7 0.2 0.015 15.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) HSBP1 PF06825.12 CRG90191.1 - 0.1 12.4 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Glyco_hydro_76 PF03663.14 CRG90192.1 - 1.3e-21 77.6 0.0 5.4e-21 75.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CRG90192.1 - 0.061 12.4 0.0 0.14 11.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 RRM_1 PF00076.22 CRG90193.1 - 4.8e-15 55.1 0.0 6.9e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG90193.1 - 0.015 14.9 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 CRG90193.1 - 0.062 13.4 0.0 0.09 12.8 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif Bax1-I PF01027.20 CRG90194.1 - 6.8e-33 114.2 8.4 9.7e-33 113.7 8.4 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CGI-121 PF08617.10 CRG90195.1 - 1.2e-55 188.1 0.1 1.3e-55 187.9 0.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Slx4 PF09494.10 CRG90196.1 - 2.6e-23 81.7 0.0 5.7e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 Slx4 endonuclease Spore_Cse60 PF10957.8 CRG90197.1 - 0.14 12.2 0.4 0.46 10.6 0.4 1.9 1 0 0 1 1 1 0 Sporulation protein Cse60 DUF4407 PF14362.6 CRG90197.1 - 0.34 10.2 6.5 0.091 12.1 3.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 CRG90197.1 - 2.8 5.7 4.0 5 4.9 4.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CASP_C PF08172.12 CRG90197.1 - 4.1 6.7 9.4 0.25 10.7 3.0 2.1 2 0 0 2 2 2 0 CASP C terminal Atg14 PF10186.9 CRG90197.1 - 4.3 6.3 17.7 0.47 9.5 9.6 2.3 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 CRG90197.1 - 5.9 7.0 14.7 0.43 10.6 6.9 2.6 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein cNMP_binding PF00027.29 CRG90198.1 - 1.4e-36 124.4 0.0 2e-21 75.9 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain cNMPbd_u2 PF16643.5 CRG90198.1 - 9.4e-31 107.4 7.0 9.4e-31 107.4 7.0 2.2 2 0 0 2 2 2 1 Unstructured region on cNMP-binding protein LRR_4 PF12799.7 CRG90198.1 - 4.5e-10 39.6 3.4 0.16 12.4 0.2 6.8 7 1 0 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 CRG90198.1 - 5.4e-08 32.3 9.0 2.3 8.5 0.0 8.4 9 1 0 9 9 9 1 Leucine Rich repeat F-box-like PF12937.7 CRG90198.1 - 8.4e-06 25.6 2.0 1.6e-05 24.7 0.8 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CRG90198.1 - 0.00088 19.1 1.8 0.00088 19.1 1.8 3.4 3 0 0 3 3 3 1 F-box domain LRR_1 PF00560.33 CRG90198.1 - 0.005 17.2 13.3 18 6.4 0.0 7.6 8 0 0 8 8 8 1 Leucine Rich Repeat SAM_Ste50p PF09235.10 CRG90198.1 - 0.85 9.9 3.1 21 5.5 0.3 3.8 3 1 0 3 3 3 0 Ste50p, sterile alpha motif Colipase-like PF15083.6 CRG90198.1 - 2 8.6 6.4 1.1 9.4 3.5 2.2 2 0 0 2 2 2 0 Colipase-like Tim17 PF02466.19 CRG90199.1 - 8.2e-05 23.0 1.5 0.00013 22.3 1.5 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Kinesin PF00225.23 CRG90200.1 - 7.8e-119 396.5 0.0 1.4e-118 395.7 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CRG90200.1 - 2.5e-27 95.6 0.0 7.4e-27 94.1 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding AAA_33 PF13671.6 CRG90200.1 - 0.0089 16.2 0.2 0.05 13.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain Herpes_UL14 PF03580.14 CRG90200.1 - 0.012 15.9 3.6 0.036 14.3 3.6 1.8 1 0 0 1 1 1 0 Herpesvirus UL14-like protein PMSR PF01625.21 CRG90201.1 - 4.3e-63 212.1 0.3 5e-63 211.9 0.3 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pro_dh PF01619.18 CRG90202.1 - 5.5e-66 223.1 0.0 7.6e-66 222.6 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase Glyco_hydro_16 PF00722.21 CRG90204.1 - 2.4e-44 150.9 1.6 4.2e-44 150.1 1.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 CRG90204.1 - 0.042 14.3 16.1 0.11 13.0 16.1 1.6 1 0 0 1 1 1 0 Chitin recognition protein SWIRM-assoc_2 PF16496.5 CRG90205.1 - 0.66 8.8 7.0 0.062 12.2 2.0 1.7 2 0 0 2 2 2 0 SWIRM-associated domain at the N-terminal Spt5_N PF11942.8 CRG90205.1 - 2.8 9.0 11.7 3.6 8.6 1.5 3.3 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Alk_phosphatase PF00245.20 CRG90206.1 - 1.6e-106 356.7 0.0 2.4e-106 356.2 0.0 1.2 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 CRG90206.1 - 2.1e-05 24.1 0.0 3.7e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Amidohydro_1 PF01979.20 CRG90207.1 - 7.3e-30 104.5 0.2 5.1e-28 98.4 0.2 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG90207.1 - 5.5e-16 59.1 0.2 2e-08 34.1 0.0 2.6 3 0 0 3 3 3 2 Amidohydrolase family DUF498 PF04430.14 CRG90208.1 - 2e-29 101.8 0.0 2.9e-29 101.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) ABC_membrane PF00664.23 CRG90209.1 - 4.9e-37 128.1 9.2 4.9e-37 128.1 9.2 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region ABC_tran PF00005.27 CRG90209.1 - 4.5e-33 114.7 0.0 1.5e-32 113.0 0.0 2.0 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CRG90209.1 - 1.1e-06 28.3 0.1 1.4e-05 24.7 0.1 2.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG90209.1 - 0.0066 16.7 0.1 0.035 14.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 CRG90209.1 - 0.025 14.8 0.3 0.78 10.0 0.3 2.9 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 CRG90209.1 - 0.035 14.5 1.4 0.22 11.9 1.4 2.3 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 CRG90209.1 - 0.055 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 CRG90209.1 - 0.068 12.9 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 CRG90210.1 - 4.5e-12 46.3 14.8 1.4e-05 25.7 0.1 6.0 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90210.1 - 4.7e-07 30.0 0.1 1.6 9.1 0.0 4.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG90210.1 - 2.2e-06 27.7 0.0 0.0012 18.8 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A zf-rbx1 PF12678.7 CRG90210.1 - 0.94 9.8 9.9 0.06 13.6 0.9 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zinc_ribbon_16 PF17034.5 CRG90210.1 - 1.9 8.7 7.7 0.3 11.3 1.5 2.7 3 0 0 3 3 3 0 Zinc-ribbon like family XLF PF09302.11 CRG90211.1 - 1.3e-44 152.6 0.0 2.1e-44 151.8 0.0 1.4 1 0 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component CactinC_cactus PF09732.9 CRG90212.1 - 4.4e-58 194.7 6.7 8.4e-58 193.8 6.7 1.5 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 CRG90212.1 - 1.7e-55 187.8 9.4 1.3e-53 181.6 6.9 2.7 1 1 1 2 2 2 1 Conserved mid region of cactin SF3A2 PF16835.5 CRG90212.1 - 0.035 14.5 0.0 0.14 12.5 0.0 2.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) DUF1087 PF06465.13 CRG90212.1 - 0.054 13.5 0.4 0.054 13.5 0.4 2.5 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1087) Forkhead PF00250.18 CRG90213.1 - 2.5e-17 62.9 0.7 4.4e-17 62.1 0.7 1.3 1 0 0 1 1 1 1 Forkhead domain Ribosomal_L34e PF01199.18 CRG90214.1 - 1.4e-42 143.9 2.4 2.2e-42 143.2 2.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L34e Vps36-NZF-N PF16988.5 CRG90214.1 - 0.029 13.7 1.1 0.05 13.0 0.0 2.0 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FhuF_C PF11575.8 CRG90214.1 - 0.81 9.7 4.9 3.5 7.7 0.3 2.7 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PROCN PF08083.11 CRG90215.1 - 6.9e-235 779.2 8.1 6.9e-235 779.2 8.1 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 CRG90215.1 - 9.6e-127 421.3 1.3 1.7e-126 420.4 1.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 CRG90215.1 - 6.9e-89 295.8 1.9 2.2e-88 294.2 1.9 1.9 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 CRG90215.1 - 1.9e-80 268.1 1.3 1.9e-80 268.1 1.3 2.0 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 CRG90215.1 - 2.3e-71 238.1 0.1 5.6e-71 236.9 0.1 1.7 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 CRG90215.1 - 3.8e-48 161.8 0.4 1.1e-47 160.3 0.4 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 CRG90215.1 - 5.7e-48 161.9 0.0 1.6e-47 160.5 0.0 1.8 1 0 0 1 1 1 1 PROCT (NUC072) domain YflT PF11181.8 CRG90215.1 - 0.16 12.5 0.7 0.58 10.7 0.7 2.0 1 0 0 1 1 1 0 Heat induced stress protein YflT tRNA-synt_1b PF00579.25 CRG90216.1 - 2.5e-22 79.6 0.0 4.4e-22 78.7 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Myb_DNA-bind_6 PF13921.6 CRG90217.1 - 2.1e-12 47.1 0.1 3.1e-07 30.5 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG90217.1 - 1.6e-09 37.8 0.2 0.00016 21.8 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain COX5B PF01215.19 CRG90218.1 - 2.1e-53 179.5 0.0 2.8e-53 179.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Transp_cyt_pur PF02133.15 CRG90219.1 - 6.1e-13 48.3 39.6 9.1e-13 47.8 39.6 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Myb_DNA-binding PF00249.31 CRG90219.1 - 5.7e-08 32.8 0.7 0.013 15.6 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG90219.1 - 0.00077 19.7 1.2 0.067 13.5 0.3 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Sortilin-Vps10 PF15902.5 CRG90219.1 - 0.19 10.5 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Sortilin, neurotensin receptor 3, Myb_DNA-bind_6 PF13921.6 CRG90220.1 - 0.00014 22.0 0.0 0.028 14.6 0.0 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG90220.1 - 0.00046 20.3 0.3 0.0018 18.4 0.1 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain ER_lumen_recept PF00810.18 CRG90222.1 - 1.6e-41 142.5 10.5 1.6e-41 142.5 10.5 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor Peptidase_A8 PF01252.18 CRG90222.1 - 0.018 15.3 0.7 0.064 13.5 0.6 1.9 1 1 0 1 1 1 0 Signal peptidase (SPase) II DUF5368 PF17336.2 CRG90222.1 - 0.11 12.7 0.6 0.11 12.7 0.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5368) PQ-loop PF04193.14 CRG90222.1 - 0.46 10.3 0.1 0.46 10.3 0.1 3.4 4 0 0 4 4 4 0 PQ loop repeat Ribosomal_L27A PF00828.19 CRG90223.1 - 1.5e-21 77.4 0.0 2.2e-21 76.9 0.0 1.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A eRF1_1 PF03463.15 CRG90224.1 - 1.4e-45 154.4 0.0 2.1e-45 153.8 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 CRG90224.1 - 2.3e-18 66.7 0.0 4.8e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 CRG90224.1 - 7.5e-16 58.7 0.1 3.1e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 eRF1 domain 2 Ribosomal_S19e PF01090.19 CRG90226.1 - 2.5e-56 189.2 0.2 4.7e-56 188.3 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S19e Abhydrolase_6 PF12697.7 CRG90226.1 - 6.1e-15 56.4 0.4 1.9e-14 54.8 0.4 1.9 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG90226.1 - 9.3e-14 51.3 0.0 8e-13 48.2 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG90226.1 - 2.9e-13 50.1 0.1 1.6e-12 47.7 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold DSPc PF00782.20 CRG90226.1 - 6.8e-10 38.9 0.0 1.4e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Ser_hydrolase PF06821.13 CRG90226.1 - 0.00092 19.1 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 Serine hydrolase Thioesterase PF00975.20 CRG90226.1 - 0.0091 16.1 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 Thioesterase domain Y_phosphatase PF00102.27 CRG90226.1 - 0.029 13.9 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 Protein-tyrosine phosphatase FSH1 PF03959.13 CRG90226.1 - 0.036 13.7 0.0 0.36 10.5 0.0 2.2 1 1 0 1 1 1 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 CRG90226.1 - 0.06 13.1 0.1 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 PGAP1-like protein ILVD_EDD PF00920.21 CRG90227.1 - 6e-210 698.2 1.2 7.1e-210 698.0 1.2 1.0 1 0 0 1 1 1 1 Dehydratase family DUF1772 PF08592.11 CRG90228.1 - 1.6e-27 96.5 0.2 2.2e-27 96.1 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) VirB8 PF04335.13 CRG90228.1 - 0.12 12.1 0.1 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 VirB8 protein Cu-oxidase_3 PF07732.15 CRG90229.1 - 6.6e-44 148.7 0.5 2.3e-43 147.0 0.5 2.0 1 0 0 1 1 1 1 Multicopper oxidase Pex2_Pex12 PF04757.14 CRG90229.1 - 3.9e-37 128.0 2.4 7e-37 127.2 2.4 1.4 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region Cu-oxidase PF00394.22 CRG90229.1 - 4.9e-36 124.3 0.9 4.9e-36 124.3 0.9 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG90229.1 - 1.5e-23 83.1 3.9 2.4e-20 72.7 0.1 3.4 3 1 0 3 3 3 2 Multicopper oxidase zf-C3HC4_4 PF15227.6 CRG90229.1 - 0.00049 20.2 4.8 0.001 19.2 4.8 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 CRG90229.1 - 0.25 11.2 3.7 0.56 10.1 3.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG90229.1 - 0.31 11.1 2.8 0.98 9.5 2.8 1.9 1 1 0 1 1 1 0 RING-type zinc-finger Phosphoesterase PF04185.14 CRG90230.1 - 3.8e-33 115.1 5.1 1.6e-32 113.1 4.9 1.9 1 1 0 1 1 1 1 Phosphoesterase family HIF-1a_CTAD PF08778.10 CRG90230.1 - 0.046 13.4 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 HIF-1 alpha C terminal transactivation domain IBN_N PF03810.19 CRG90232.1 - 3.9e-14 52.3 0.9 1.7e-12 47.1 0.2 3.1 2 0 0 2 2 2 2 Importin-beta N-terminal domain Cellulase PF00150.18 CRG90233.1 - 2.9e-18 66.3 4.0 6.3e-18 65.2 4.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Protoglobin PF11563.8 CRG90234.1 - 2e-60 203.3 0.0 2.4e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 Protoglobin Vps4_C PF09336.10 CRG90235.1 - 0.055 13.5 0.5 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain NinF PF05810.12 CRG90236.1 - 0.073 13.0 1.8 2.9 7.8 0.1 2.3 2 0 0 2 2 2 0 NinF protein Nucleoporin_FG2 PF15967.5 CRG90236.1 - 0.29 9.6 0.0 0.38 9.2 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region GPI-anchored PF10342.9 CRG90237.1 - 3.3e-19 69.4 0.1 3.3e-19 69.4 0.1 1.6 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Terminase_6 PF03237.15 CRG90238.1 - 0.0052 16.5 0.0 0.011 15.4 0.0 1.5 1 0 0 1 1 1 1 Terminase-like family TBCC_N PF16752.5 CRG90238.1 - 0.0061 17.0 0.4 0.021 15.2 0.4 2.0 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain ABC_tran_CTD PF16326.5 CRG90238.1 - 0.031 14.5 0.4 0.031 14.5 0.4 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain CEP209_CC5 PF16574.5 CRG90238.1 - 0.098 12.8 2.7 0.27 11.4 2.7 1.7 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 Golgin_A5 PF09787.9 CRG90238.1 - 0.89 9.0 13.6 0.048 13.1 7.3 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 Tropomyosin_1 PF12718.7 CRG90238.1 - 1.3 9.2 17.5 1.6 8.8 2.9 3.3 2 1 1 3 3 3 0 Tropomyosin like DUF2462 PF09495.10 CRG90239.1 - 2.5e-19 69.8 8.7 2.5e-19 69.8 8.7 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF2462) Zn_clus PF00172.18 CRG90240.1 - 0.0019 18.3 10.2 0.0035 17.4 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 CRG90240.1 - 0.46 10.6 4.9 1.3 9.2 4.9 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Acetyltransf_1 PF00583.25 CRG90241.1 - 0.00018 21.7 0.0 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG90241.1 - 0.023 15.1 0.0 0.046 14.2 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG90241.1 - 0.026 14.5 0.0 0.081 12.9 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SurE PF01975.17 CRG90242.1 - 5.3e-50 169.9 0.5 2.9e-49 167.5 0.5 1.9 1 1 0 1 1 1 1 Survival protein SurE DUF5427 PF10310.9 CRG90243.1 - 2.4e-168 560.9 0.9 2.9e-168 560.7 0.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Flu_M1_C PF08289.11 CRG90243.1 - 0.073 13.3 0.2 0.25 11.6 0.2 1.9 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain SARAF PF06682.12 CRG90243.1 - 0.92 9.1 5.0 1.6 8.3 5.0 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Pkinase_fungal PF17667.1 CRG90244.1 - 5e-36 124.4 0.0 5.7e-36 124.2 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Rrn6 PF10214.9 CRG90245.1 - 0.0052 15.4 9.2 0.0098 14.4 9.2 1.4 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Phage_cap_E PF03864.15 CRG90245.1 - 1.4 8.0 7.2 2.4 7.2 0.1 3.0 3 0 0 3 3 3 0 Phage major capsid protein E zf-C2H2_4 PF13894.6 CRG90246.1 - 7.2e-07 29.5 2.0 0.0077 17.0 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG90246.1 - 0.00031 21.0 2.8 0.012 16.0 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type MFS_1 PF07690.16 CRG90247.1 - 2.8e-34 118.6 17.0 2.8e-34 118.6 17.0 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily Tmemb_14 PF03647.13 CRG90247.1 - 9.5e-18 64.7 7.8 9.5e-18 64.7 7.8 3.2 3 0 0 3 3 3 1 Transmembrane proteins 14C Sugar_tr PF00083.24 CRG90247.1 - 1.6e-09 37.1 4.0 1.6e-09 37.1 4.0 2.6 2 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CRG90247.1 - 0.00052 18.6 0.5 0.001 17.6 0.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) TFR_dimer PF04253.15 CRG90248.1 - 1.5e-30 105.7 0.0 2.5e-30 105.1 0.0 1.3 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 CRG90248.1 - 4.1e-21 75.6 0.0 6.8e-21 74.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CRG90248.1 - 1.2e-11 44.4 0.8 2.3e-11 43.5 0.1 1.8 2 0 0 2 2 2 1 PA domain Nicastrin PF05450.15 CRG90248.1 - 0.0064 16.0 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 Nicastrin NDUF_B12 PF08122.12 CRG90248.1 - 0.9 9.6 4.2 15 5.7 0.1 2.9 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family RTC4 PF14474.6 CRG90249.1 - 2.3e-32 111.7 0.0 5.2e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain Menin PF05053.13 CRG90249.1 - 3.3 6.0 12.8 4.9 5.4 12.8 1.2 1 0 0 1 1 1 0 Menin GET2 PF08690.10 CRG90249.1 - 3.7 7.1 15.6 7 6.2 15.6 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 DUF726 PF05277.12 CRG90250.1 - 6.7e-127 423.1 1.7 9.8e-127 422.6 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) 5-FTHF_cyc-lig PF01812.20 CRG90250.1 - 0.32 10.8 1.9 0.51 10.1 0.1 2.1 2 0 0 2 2 2 0 5-formyltetrahydrofolate cyclo-ligase family SesA PF17107.5 CRG90251.1 - 0.0054 16.9 1.1 0.014 15.6 1.1 1.6 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Occludin_ELL PF07303.13 CRG90251.1 - 0.098 13.4 0.8 0.26 12.1 0.8 1.8 1 0 0 1 1 1 0 Occludin homology domain DUF948 PF06103.11 CRG90251.1 - 0.14 12.4 0.9 1.2 9.5 0.9 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Fungal_trans PF04082.18 CRG90252.1 - 2.4e-06 26.8 0.1 4.5e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90252.1 - 0.00049 20.2 10.1 0.00078 19.5 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG90253.1 - 4.3e-43 147.6 38.5 4.3e-43 147.6 38.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90253.1 - 6.3e-12 45.1 8.7 6.3e-12 45.1 8.7 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CRG90253.1 - 6.5e-09 35.6 6.0 6.5e-09 35.6 6.0 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 CRG90253.1 - 0.0014 17.0 10.5 0.0071 14.7 2.7 3.2 2 1 0 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family DUF3328 PF11807.8 CRG90254.1 - 1.6e-37 129.4 4.5 2.5e-37 128.8 4.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) FMO-like PF00743.19 CRG90254.1 - 9.6e-12 44.1 0.0 1.2e-07 30.6 0.0 3.0 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 CRG90254.1 - 2.2e-11 43.5 0.0 1.4e-09 37.6 0.0 2.3 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG90254.1 - 6.8e-10 38.7 0.0 1.9e-08 33.9 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG90254.1 - 3e-06 27.3 0.0 8e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG90254.1 - 7.3e-06 25.4 0.0 0.00011 21.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG90254.1 - 9.7e-06 25.0 0.0 1.7e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CRG90254.1 - 1.1e-05 25.5 0.3 0.00072 19.6 0.1 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG90254.1 - 3.6e-05 23.0 0.0 7.1e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 CRG90254.1 - 0.015 14.0 0.1 1.3 7.7 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 CRG90254.1 - 0.049 13.2 0.3 0.21 11.1 0.2 2.1 1 1 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG90254.1 - 0.23 12.0 0.9 12 6.6 0.1 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase LicD PF04991.13 CRG90256.1 - 2.7e-19 70.2 4.9 7.9e-14 52.3 2.6 2.6 1 1 1 2 2 2 2 LicD family Fungal_trans PF04082.18 CRG90256.1 - 1.9e-18 66.4 0.0 1.5e-17 63.5 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90256.1 - 4.1e-10 39.6 10.5 7.5e-10 38.8 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PspB PF06667.12 CRG90256.1 - 0.21 11.7 0.8 0.55 10.3 0.1 2.0 2 0 0 2 2 2 0 Phage shock protein B DAD PF02109.16 CRG90257.1 - 4.3e-47 158.9 0.6 5.2e-47 158.7 0.6 1.1 1 0 0 1 1 1 1 DAD family HA2 PF04408.23 CRG90258.1 - 3.1e-21 75.7 1.2 2e-20 73.1 0.0 2.8 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CRG90258.1 - 5.1e-16 58.8 0.0 1.8e-15 57.1 0.0 1.9 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CRG90258.1 - 6e-15 55.6 0.0 1.4e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG90258.1 - 3e-06 27.1 0.0 7.3e-06 25.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CRG90258.1 - 4.5e-05 23.8 0.0 0.00012 22.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG90258.1 - 0.001 18.8 0.0 0.0024 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 CRG90258.1 - 0.0023 17.3 0.0 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.6 CRG90258.1 - 0.0032 17.8 0.1 0.0089 16.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CRG90258.1 - 0.0034 16.5 0.0 0.0098 15.0 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 CRG90258.1 - 0.0035 16.6 0.0 0.0065 15.8 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SRP54 PF00448.22 CRG90258.1 - 0.0099 15.5 0.3 0.027 14.1 0.3 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CRG90258.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 CRG90258.1 - 0.019 15.0 0.0 7.8 6.5 0.0 2.6 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_14 PF13173.6 CRG90258.1 - 0.021 14.9 0.2 0.11 12.5 0.2 2.1 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 CRG90258.1 - 0.022 14.7 0.1 0.04 13.9 0.1 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_33 PF13671.6 CRG90258.1 - 0.059 13.5 0.8 0.35 11.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 CRG90258.1 - 0.07 13.0 0.2 1.2 9.0 0.0 2.5 3 0 0 3 3 2 0 NACHT domain ABC_tran PF00005.27 CRG90258.1 - 0.093 13.2 0.2 0.38 11.3 0.0 2.1 2 0 0 2 2 1 0 ABC transporter AAA_16 PF13191.6 CRG90258.1 - 0.1 13.0 0.0 0.3 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 CRG90258.1 - 0.1 12.1 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Prefoldin_2 PF01920.20 CRG90259.1 - 9.3e-25 86.6 3.4 1.2e-24 86.3 3.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 CRG90259.1 - 0.00065 19.6 3.8 0.054 13.4 3.8 2.1 1 1 0 1 1 1 1 Prefoldin subunit CLZ PF16526.5 CRG90259.1 - 0.029 14.7 2.7 2.2 8.7 0.1 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MutS_IV PF05190.18 CRG90259.1 - 0.035 14.4 0.8 0.39 11.1 0.0 2.1 2 0 0 2 2 2 0 MutS family domain IV CENP-F_leu_zip PF10473.9 CRG90259.1 - 0.12 12.4 4.7 0.098 12.7 0.9 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CC2-LZ PF16516.5 CRG90259.1 - 0.24 11.8 4.5 4.6 7.7 0.7 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF2205 PF10224.9 CRG90259.1 - 0.31 11.1 3.4 0.81 9.7 1.0 2.1 2 0 0 2 2 2 0 Short coiled-coil protein DUF4795 PF16043.5 CRG90259.1 - 0.6 9.7 5.3 2.8 7.5 1.1 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) CBFD_NFYB_HMF PF00808.23 CRG90260.1 - 2.5e-29 101.4 0.9 3.4e-29 100.9 0.9 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CRG90260.1 - 6.4e-06 26.6 0.0 9.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 CRG90260.1 - 0.002 18.1 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-T_C PF15511.6 CRG90260.1 - 0.0031 17.6 0.0 0.0041 17.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 CRG90260.1 - 0.0034 17.3 0.1 0.0055 16.7 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 CRG90260.1 - 0.09 13.3 0.1 0.27 11.7 0.0 1.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Fungal_trans PF04082.18 CRG90261.1 - 3.5e-21 75.4 0.3 2.7e-20 72.5 0.0 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90261.1 - 1.5e-09 37.8 12.1 2.4e-09 37.2 12.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 CRG90261.1 - 2.8 7.9 14.6 0.23 11.4 7.4 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit zinc_ribbon_6 PF14599.6 CRG90261.1 - 3.6 7.7 6.3 2.6 8.1 1.3 3.0 3 0 0 3 3 3 0 Zinc-ribbon Fungal_trans PF04082.18 CRG90262.1 - 5.7e-24 84.6 0.4 8.4e-24 84.0 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90262.1 - 1.6e-09 37.7 8.3 2.6e-09 37.0 8.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC_tran PF00005.27 CRG90263.1 - 1.5e-64 216.6 0.0 5.1e-32 111.2 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG90263.1 - 4.1e-62 210.3 32.2 6.3e-43 147.4 12.7 4.1 2 1 2 4 4 4 4 ABC transporter transmembrane region SMC_N PF02463.19 CRG90263.1 - 8.2e-19 67.9 4.1 3.3e-07 30.0 1.1 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG90263.1 - 7.6e-08 32.7 1.0 0.028 14.7 0.1 4.0 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CRG90263.1 - 3.6e-07 29.8 2.0 0.00089 19.0 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG90263.1 - 2.5e-06 27.5 0.1 0.017 15.1 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 CRG90263.1 - 1.4e-05 25.7 1.2 0.041 14.4 0.1 2.8 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 CRG90263.1 - 1.7e-05 23.8 5.5 0.0036 16.1 0.1 3.2 4 0 0 4 4 4 2 Predicted ATPase of the ABC class ATP-synt_ab PF00006.25 CRG90263.1 - 2.5e-05 24.1 0.1 0.17 11.5 0.0 2.8 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.6 CRG90263.1 - 4.7e-05 23.3 0.7 0.063 13.0 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 CRG90263.1 - 7.3e-05 23.2 3.2 0.31 11.4 0.2 3.3 2 2 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CRG90263.1 - 0.00011 22.2 2.4 0.26 11.1 0.1 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 CRG90263.1 - 0.00022 21.4 0.3 0.35 10.9 0.2 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_30 PF13604.6 CRG90263.1 - 0.00051 19.8 2.1 0.51 10.0 0.2 3.3 3 1 0 3 3 3 2 AAA domain AAA_25 PF13481.6 CRG90263.1 - 0.00069 19.2 0.0 6.1 6.4 0.0 3.7 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 CRG90263.1 - 0.00084 19.5 1.1 0.26 11.5 0.3 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 CRG90263.1 - 0.0037 17.2 0.0 2.3 8.2 0.0 3.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Dala_Dala_lig_N PF01820.21 CRG90263.1 - 0.033 14.7 0.0 0.15 12.5 0.0 2.1 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_24 PF13479.6 CRG90263.1 - 0.037 13.7 0.1 11 5.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 CRG90263.1 - 0.063 13.1 0.1 12 5.6 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 CRG90263.1 - 0.082 12.2 0.2 11 5.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family PRK PF00485.18 CRG90263.1 - 0.084 12.6 0.3 9.3 5.9 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_7 PF12775.7 CRG90263.1 - 0.085 12.4 0.0 13 5.3 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region G-alpha PF00503.20 CRG90263.1 - 0.12 11.5 0.0 11 5.0 0.0 2.4 2 0 0 2 2 2 0 G-protein alpha subunit NB-ARC PF00931.22 CRG90263.1 - 0.13 11.5 1.0 12 4.9 0.2 2.6 2 1 0 2 2 2 0 NB-ARC domain Zeta_toxin PF06414.12 CRG90263.1 - 0.13 11.5 0.4 17 4.6 0.0 2.8 3 0 0 3 3 3 0 Zeta toxin AAA_18 PF13238.6 CRG90263.1 - 0.14 12.7 0.1 26 5.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CRG90263.1 - 0.14 12.0 0.1 10 6.0 0.0 2.7 2 0 0 2 2 2 0 NACHT domain ATPase PF06745.13 CRG90263.1 - 0.21 10.9 1.5 3.8 6.8 0.1 2.8 3 0 0 3 3 3 0 KaiC MoaE PF02391.17 CRG90263.1 - 2.3 8.5 4.5 23 5.3 0.3 2.8 3 0 0 3 3 2 0 MoaE protein FSH1 PF03959.13 CRG90264.1 - 1e-30 107.0 0.0 6e-30 104.5 0.0 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) PE-PPE PF08237.11 CRG90264.1 - 0.17 11.4 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain KR PF08659.10 CRG90265.1 - 1.1e-60 204.6 2.4 4.1e-60 202.8 0.6 2.6 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 CRG90265.1 - 6.6e-55 186.8 0.0 1.2e-54 186.0 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CRG90265.1 - 3.9e-46 157.6 0.0 6e-46 157.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CRG90265.1 - 1e-40 138.4 0.1 7.2e-40 135.7 0.0 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ketoacyl-synt PF00109.26 CRG90265.1 - 3.3e-32 112.0 0.2 9.3e-32 110.6 0.0 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KAsynt_C_assoc PF16197.5 CRG90265.1 - 1.9e-19 70.2 0.0 5.5e-19 68.7 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG90265.1 - 1.5e-15 57.2 2.4 3.7e-15 55.9 0.6 2.5 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 CRG90265.1 - 4.4e-10 40.7 0.0 3.3e-09 37.9 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CRG90265.1 - 3e-09 36.8 1.4 7.5e-09 35.5 1.4 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CRG90265.1 - 1.1e-06 28.9 1.0 3.5e-06 27.3 1.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 CRG90265.1 - 3.7e-05 23.0 0.1 7e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ADH_N PF08240.12 CRG90265.1 - 0.00012 22.0 0.2 0.00029 20.7 0.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG90265.1 - 0.00028 20.8 0.0 0.001 19.1 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NmrA PF05368.13 CRG90265.1 - 0.019 14.5 0.1 0.019 14.5 0.1 2.0 2 0 0 2 2 2 0 NmrA-like family TatD_DNase PF01026.21 CRG90266.1 - 1.8e-35 122.6 0.0 2.5e-35 122.1 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Abhydrolase_1 PF00561.20 CRG90268.1 - 8.9e-21 74.7 0.0 1.8e-18 67.2 0.0 2.6 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG90268.1 - 1.1e-17 65.4 0.4 1.1e-16 62.1 0.4 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG90268.1 - 5.2e-17 61.9 0.0 2.4e-16 59.7 0.0 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DUF915 PF06028.11 CRG90268.1 - 4e-06 26.4 0.0 7.2e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 CRG90268.1 - 4.6e-06 26.5 0.0 1.3e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Chlorophyllase2 PF12740.7 CRG90268.1 - 8.6e-05 21.6 0.0 0.00016 20.7 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Ser_hydrolase PF06821.13 CRG90268.1 - 0.00022 21.1 0.0 0.022 14.6 0.0 3.0 3 0 0 3 3 3 1 Serine hydrolase LIDHydrolase PF10230.9 CRG90268.1 - 0.00081 19.0 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_2 PF02230.16 CRG90268.1 - 0.002 18.0 0.0 0.21 11.4 0.0 2.7 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 CRG90268.1 - 0.0027 17.6 0.0 0.0064 16.4 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase PF07224.11 CRG90268.1 - 0.0059 15.7 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Thioesterase PF00975.20 CRG90268.1 - 0.026 14.6 0.1 0.083 13.0 0.1 1.9 1 1 0 1 1 1 0 Thioesterase domain Peptidase_S9 PF00326.21 CRG90268.1 - 0.03 13.8 0.0 0.096 12.1 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family PGAP1 PF07819.13 CRG90268.1 - 0.065 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Ndr PF03096.14 CRG90268.1 - 0.075 11.7 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Ndr family Abhydrolase_5 PF12695.7 CRG90268.1 - 0.08 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family Lipase_3 PF01764.25 CRG90268.1 - 0.12 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.12 CRG90268.1 - 0.16 11.5 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Spo7 PF03907.13 CRG90269.1 - 2.3e-93 311.7 0.2 3.6e-93 311.1 0.2 1.3 1 0 0 1 1 1 1 Spo7-like protein GTP_EFTU PF00009.27 CRG90270.1 - 1.2e-33 116.3 0.0 9.4e-33 113.4 0.0 2.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 CRG90270.1 - 2.9e-20 72.3 0.1 1e-19 70.6 0.1 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 CRG90270.1 - 6.3e-11 42.5 6.2 1.2e-09 38.5 0.0 3.9 4 0 0 4 4 4 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 CRG90270.1 - 3.2e-09 36.6 0.2 1.1e-08 34.8 0.2 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 CRG90270.1 - 7e-07 29.3 0.4 7.9e-06 25.9 0.0 2.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 CRG90270.1 - 0.00059 20.1 0.0 0.0019 18.4 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 CRG90270.1 - 0.0075 16.1 0.0 0.029 14.2 0.0 2.2 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein p450 PF00067.22 CRG90271.1 - 4.6e-57 193.8 0.0 6.7e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 SRP68 PF16969.5 CRG90272.1 - 1.6e-182 608.4 1.2 1.8e-182 608.2 1.2 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 TPR_12 PF13424.6 CRG90272.1 - 0.015 15.6 3.3 2.9 8.3 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR_2 PF13041.6 CRG90273.1 - 1.9e-19 69.6 2.3 8.9e-11 41.8 0.0 7.0 6 1 2 8 8 8 4 PPR repeat family PPR PF01535.20 CRG90273.1 - 1.1e-13 50.4 6.3 0.092 13.0 0.0 9.6 11 0 0 11 11 11 4 PPR repeat PPR_3 PF13812.6 CRG90273.1 - 2.8e-12 46.5 0.1 5.7e-07 29.5 0.0 6.3 6 1 1 7 7 7 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 CRG90273.1 - 1.1e-09 37.9 1.8 0.14 11.9 0.0 5.3 6 0 0 6 6 6 3 PPR repeat ATP13 PF12921.7 CRG90273.1 - 3e-06 27.1 0.1 0.13 12.2 0.0 4.8 5 0 0 5 5 5 2 Mitochondrial ATPase expression PPR_long PF17177.4 CRG90273.1 - 0.00013 21.4 0.8 0.21 10.9 0.1 4.0 4 1 1 5 5 5 2 Pentacotripeptide-repeat region of PRORP MCM PF00493.23 CRG90274.1 - 1.2e-94 315.6 0.0 2.1e-94 314.8 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 CRG90274.1 - 1.5e-30 105.6 0.0 2.9e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 CRG90274.1 - 2e-24 85.8 1.5 4.2e-24 84.8 1.5 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 CRG90274.1 - 4.6e-11 43.2 0.0 1.5e-10 41.6 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 CRG90274.1 - 1.4e-06 27.9 0.0 1.6e-05 24.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 CRG90274.1 - 0.0024 17.7 0.0 0.0091 15.9 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CRG90274.1 - 0.085 12.9 0.0 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CRG90274.1 - 0.11 12.2 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain MMS1_N PF10433.9 CRG90275.1 - 6.5e-93 312.0 0.0 1.4e-92 310.9 0.0 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CRG90275.1 - 1.1e-08 34.8 0.0 2.7e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 CPSF A subunit region RabGAP-TBC PF00566.18 CRG90276.1 - 2.3e-19 69.9 0.0 3.4e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Yip1 PF04893.17 CRG90276.1 - 3.2e-13 49.8 13.4 6.1e-13 48.8 13.4 1.5 1 0 0 1 1 1 1 Yip1 domain YIF1 PF03878.15 CRG90276.1 - 0.019 14.5 2.5 0.022 14.3 0.9 1.9 2 0 0 2 2 2 0 YIF1 ubiquitin PF00240.23 CRG90277.1 - 6.6e-32 109.1 1.8 7.6e-32 108.9 0.5 1.8 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_L40e PF01020.17 CRG90277.1 - 5.1e-30 103.1 11.0 9.9e-30 102.2 11.0 1.5 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 CRG90277.1 - 1.4e-13 50.5 0.3 3.3e-13 49.3 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zf-RRN7 PF11781.8 CRG90277.1 - 1.2e-07 31.3 6.2 1.2e-07 31.3 6.2 2.0 2 0 0 2 2 2 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Ubiquitin_2 PF14560.6 CRG90277.1 - 0.00061 20.2 0.1 0.0019 18.6 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 CRG90277.1 - 0.036 14.0 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CRG90277.1 - 0.04 14.3 0.7 0.091 13.1 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain tRNA-synt_2b PF00587.25 CRG90277.1 - 0.11 12.4 0.0 0.29 11.1 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Rad60-SLD_2 PF13881.6 CRG90277.1 - 0.12 12.4 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like eIF-5a PF01287.20 CRG90278.1 - 7.4e-30 102.9 1.6 1e-29 102.4 1.6 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 CRG90278.1 - 0.0079 16.2 0.1 0.017 15.1 0.0 1.6 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain NTR2 PF15458.6 CRG90278.1 - 0.12 11.9 0.1 0.15 11.6 0.1 1.1 1 0 0 1 1 1 0 Nineteen complex-related protein 2 Vps52 PF04129.12 CRG90279.1 - 6.5e-120 401.3 0.0 8.3e-120 400.9 0.0 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 CRG90279.1 - 0.00021 19.8 3.6 0.00042 18.9 2.7 1.9 2 1 0 2 2 2 1 Exocyst complex component Sec3 MitMem_reg PF13012.6 CRG90279.1 - 0.011 16.1 2.9 0.45 11.0 1.2 3.2 3 1 0 3 3 3 0 Maintenance of mitochondrial structure and function Exo70 PF03081.15 CRG90279.1 - 0.045 12.8 1.9 1.6 7.7 0.1 2.5 2 0 0 2 2 2 0 Exo70 exocyst complex subunit Laminin_II PF06009.12 CRG90279.1 - 0.074 13.1 2.3 1.6 8.7 0.1 2.5 2 0 0 2 2 2 0 Laminin Domain II COG2 PF06148.11 CRG90279.1 - 0.48 10.5 2.1 0.76 9.9 0.2 2.2 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DAO PF01266.24 CRG90280.1 - 3.4e-67 227.5 0.2 3.9e-67 227.3 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG90280.1 - 2.4e-05 24.5 0.1 5.7e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG90280.1 - 0.0004 19.7 0.2 0.11 11.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 CRG90280.1 - 0.014 15.3 0.4 0.027 14.4 0.4 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.17 CRG90280.1 - 0.017 14.4 0.0 0.033 13.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 CRG90280.1 - 0.019 14.2 0.1 0.033 13.4 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain AlaDh_PNT_C PF01262.21 CRG90280.1 - 0.1 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CRG90280.1 - 0.11 13.1 0.1 1.5 9.5 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CRG90280.1 - 0.15 11.7 0.1 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_2 PF00890.24 CRG90280.1 - 0.19 10.7 1.7 0.36 9.8 1.7 1.5 1 1 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 CRG90280.1 - 0.21 10.9 1.3 0.38 10.0 1.3 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Fungal_trans PF04082.18 CRG90281.1 - 2.9e-13 49.5 1.0 8.3e-13 48.0 1.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain zf-H2C2_2 PF13465.6 CRG90281.1 - 1.3e-06 28.5 8.0 1.3e-06 28.5 8.0 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 CRG90281.1 - 2.4e-06 27.7 15.3 0.0086 16.5 2.0 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG90281.1 - 2.6e-05 24.7 12.8 0.014 16.2 1.5 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 CRG90281.1 - 9e-05 22.7 9.4 0.057 13.8 0.8 3.0 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 CRG90281.1 - 0.00035 20.8 9.8 0.09 13.1 5.1 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 CRG90281.1 - 0.015 15.3 1.1 0.015 15.3 1.1 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger PHD_4 PF16866.5 CRG90281.1 - 0.053 13.6 1.7 0.15 12.1 1.7 1.7 1 0 0 1 1 1 0 PHD-finger zf-C2HC_2 PF13913.6 CRG90281.1 - 0.23 11.4 6.9 1.1 9.3 1.2 2.9 2 0 0 2 2 2 0 zinc-finger of a C2HC-type AAA_16 PF13191.6 CRG90283.1 - 0.14 12.5 0.1 0.82 10.0 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain DNase_NucA_NucB PF14040.6 CRG90284.1 - 1e-05 25.8 0.0 1e-05 25.8 0.0 2.3 2 0 0 2 2 2 1 Deoxyribonuclease NucA/NucB FAD_binding_4 PF01565.23 CRG90285.1 - 4.3e-28 97.8 0.1 7.2e-28 97.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain FAD-oxidase_C PF02913.19 CRG90285.1 - 4.2e-14 52.8 0.0 7.2e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain DUF4113 PF13438.6 CRG90285.1 - 0.028 14.5 0.0 0.077 13.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4113) CoA_trans PF01144.23 CRG90286.1 - 1.1e-93 312.6 0.7 7.9e-56 188.9 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Thiolase_N PF00108.23 CRG90287.1 - 4.2e-76 255.7 0.3 6.8e-76 255.1 0.3 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG90287.1 - 3.7e-41 139.6 0.0 1.7e-40 137.5 0.0 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CRG90287.1 - 0.00029 20.5 3.9 0.00032 20.4 1.3 2.3 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Lyase_1 PF00206.20 CRG90288.1 - 9.2e-46 156.7 0.0 2.1e-45 155.5 0.0 1.5 1 1 0 1 1 1 1 Lyase ADSL_C PF10397.9 CRG90288.1 - 6.3e-22 77.9 0.0 6.3e-21 74.7 0.0 2.4 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.11 CRG90288.1 - 0.0039 17.3 0.0 0.013 15.6 0.0 1.9 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminal HgmA PF04209.13 CRG90289.1 - 1.8e-134 448.6 0.0 2.1e-134 448.5 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase SOG2 PF10428.9 CRG90290.1 - 3.9 6.6 8.9 4.3 6.4 8.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein RRM_1 PF00076.22 CRG90291.1 - 6.9e-80 262.9 6.1 3.3e-20 71.7 0.1 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 CRG90291.1 - 6.9e-29 99.8 0.4 4.4e-28 97.2 0.5 2.3 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 CRG90291.1 - 1.3e-13 50.7 0.3 0.0015 18.2 0.0 5.1 2 1 3 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG90291.1 - 0.0001 22.3 0.8 7.4 6.8 0.0 5.3 5 1 0 5 5 5 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CRG90291.1 - 0.00013 21.9 0.7 9 6.4 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.8 CRG90291.1 - 0.00044 20.3 0.0 3.6 7.8 0.0 3.6 3 0 0 3 3 3 1 Cobalamin biosynthesis central region YflT PF11181.8 CRG90291.1 - 0.00077 19.9 1.8 0.052 14.1 0.7 2.8 2 0 0 2 2 2 1 Heat induced stress protein YflT Limkain-b1 PF11608.8 CRG90291.1 - 0.0046 17.0 1.5 6.4 6.9 0.1 3.7 3 0 0 3 3 3 1 Limkain b1 SAPS PF04499.15 CRG90291.1 - 0.071 11.9 5.4 0.14 10.9 5.4 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DNA_pol_phi PF04931.13 CRG90291.1 - 0.26 9.3 14.2 0.42 8.6 14.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4834 PF16118.5 CRG90291.1 - 0.39 11.7 8.5 0.068 14.1 3.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) NPR3 PF03666.13 CRG90291.1 - 2.2 6.9 6.9 3.7 6.2 6.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 CRG90291.1 - 7.4 6.9 16.9 0.56 10.5 10.6 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 HECT PF00632.25 CRG90292.1 - 4.8e-82 275.9 0.0 7.4e-82 275.3 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 CRG90292.1 - 0.0015 18.1 1.7 0.0057 16.3 1.7 2.1 1 0 0 1 1 1 1 IQ calmodulin-binding motif MRP-L27 PF09809.9 CRG90293.1 - 1.1e-12 47.8 0.2 1.3e-12 47.5 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 Utp14 PF04615.13 CRG90294.1 - 3.3e-219 730.3 70.3 3.3e-219 730.3 70.3 2.0 1 1 1 2 2 2 1 Utp14 protein CheX PF13690.6 CRG90294.1 - 0.13 12.5 0.3 0.47 10.7 0.3 2.0 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX Glyco_hydro81C PF17652.1 CRG90295.1 - 6.4e-159 528.8 4.1 9.2e-159 528.3 4.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 CRG90295.1 - 4.3e-115 384.3 0.6 8.1e-115 383.4 0.6 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Na_Ca_ex PF01699.24 CRG90295.1 - 1.2e-41 142.2 38.6 1.1e-20 74.1 18.0 2.5 2 0 0 2 2 2 2 Sodium/calcium exchanger protein CsbD PF05532.12 CRG90295.1 - 0.21 11.5 0.1 0.42 10.5 0.1 1.4 1 0 0 1 1 1 0 CsbD-like PNP_UDP_1 PF01048.20 CRG90296.1 - 7.9e-29 100.6 0.0 7.3e-14 51.6 0.0 3.5 2 1 0 2 2 2 2 Phosphorylase superfamily T2SSE_N PF05157.15 CRG90296.1 - 0.019 15.2 0.0 0.29 11.4 0.0 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein E, N-terminal domain Ribosomal_S7 PF00177.21 CRG90297.1 - 6.9e-29 100.4 0.0 1.3e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e SPX PF03105.19 CRG90298.1 - 4.7e-36 125.5 8.1 1.4e-25 91.0 0.0 2.7 2 1 1 3 3 3 2 SPX domain Na_sulph_symp PF00939.19 CRG90298.1 - 3.9e-30 105.3 47.1 6.1e-30 104.7 47.1 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 CRG90298.1 - 1.4e-24 86.8 43.0 1.4e-24 86.8 43.0 1.8 2 1 0 2 2 2 1 Citrate transporter Cytochrome-c551 PF10643.9 CRG90298.1 - 0.092 12.3 3.2 0.089 12.4 0.2 2.5 3 0 0 3 3 3 0 Photosystem P840 reaction-centre cytochrome c-551 PAT1 PF09770.9 CRG90299.1 - 6.8 4.8 18.8 7.8 4.6 18.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 REV PF00424.18 CRG90300.1 - 0.39 10.8 5.2 0.86 9.7 5.2 1.5 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) TFIIF_alpha PF05793.12 CRG90300.1 - 0.77 8.3 21.4 0.84 8.1 21.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 CRG90300.1 - 1.5 7.5 9.4 1.6 7.4 9.4 1.0 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 CRG90300.1 - 1.7 8.0 18.2 1.9 7.8 18.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 BUD22 PF09073.10 CRG90300.1 - 1.7 7.9 24.9 2.1 7.6 24.9 1.2 1 0 0 1 1 1 0 BUD22 DUF2470 PF10615.9 CRG90301.1 - 1.5e-18 67.2 0.0 2.4e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 CRG90301.1 - 0.041 14.2 2.3 0.063 13.6 1.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4499) Ribosomal_S8e PF01201.22 CRG90302.1 - 1.2e-54 184.2 1.7 1.4e-54 184.0 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e Metallophos PF00149.28 CRG90303.1 - 3.7e-08 34.1 0.0 5.3e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG90303.1 - 1.7e-07 31.6 0.0 7.5e-06 26.2 0.0 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DOCK_N PF16172.5 CRG90304.1 - 3.2e-117 391.6 0.7 5.6e-117 390.8 0.0 1.8 2 0 0 2 2 2 1 DOCK N-terminus DHR-2 PF06920.13 CRG90304.1 - 7.5e-42 143.7 0.9 1.9e-41 142.3 0.9 1.5 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 CRG90304.1 - 2.6e-35 122.0 0.0 6.4e-35 120.7 0.0 1.7 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 CRG90304.1 - 2.6e-05 23.7 0.0 5.9e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 CRG90304.1 - 6.8e-05 22.7 0.0 0.0006 19.6 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 CRG90304.1 - 0.13 12.0 0.0 0.34 10.6 0.0 1.8 1 0 0 1 1 1 0 Variant SH3 domain Arg_repressor PF01316.21 CRG90304.1 - 0.14 12.0 0.4 0.58 9.9 0.0 2.1 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain Sec3_C PF09763.9 CRG90305.1 - 1.3e-219 731.2 5.6 1.7e-219 730.8 5.6 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 CRG90305.1 - 6.6e-28 96.7 0.1 1.3e-27 95.7 0.1 1.6 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Sec3_C_2 PF15278.6 CRG90305.1 - 0.0023 18.2 0.2 0.007 16.7 0.2 1.8 1 0 0 1 1 1 1 Sec3 exocyst complex subunit SRP40_C PF05022.12 CRG90306.1 - 9.9e-18 64.8 0.2 3.4e-17 63.1 0.2 2.0 1 0 0 1 1 1 1 SRP40, C-terminal domain F-box-like PF12937.7 CRG90307.1 - 1.1e-06 28.5 0.0 1.1e-06 28.5 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CRG90307.1 - 8.4e-05 22.3 0.0 0.0002 21.2 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 CRG90307.1 - 0.0023 17.8 0.0 0.0058 16.5 0.0 1.7 1 0 0 1 1 1 1 F-box Lactonase PF10282.9 CRG90307.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Lactonase, 7-bladed beta-propeller p450 PF00067.22 CRG90308.1 - 5.4e-45 154.0 0.0 7.8e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 His_Phos_1 PF00300.22 CRG90308.1 - 1.1e-31 110.1 0.0 2e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Cmc1 PF08583.10 CRG90309.1 - 0.013 15.5 0.6 0.018 15.1 0.6 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 CRG90309.1 - 0.034 14.3 1.1 0.049 13.8 1.1 1.3 1 0 0 1 1 1 0 CHCH domain RCC_reductase PF06405.11 CRG90309.1 - 0.05 12.8 0.0 0.058 12.6 0.0 1.1 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) DUF1992 PF09350.10 CRG90310.1 - 7.1e-24 83.8 1.5 2e-23 82.3 0.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1992) ArlS_N PF18719.1 CRG90310.1 - 0.11 12.7 0.2 0.57 10.4 0.0 2.1 2 0 0 2 2 2 0 ArlS sensor domain OCD_Mu_crystall PF02423.15 CRG90312.1 - 1.9e-13 50.0 0.0 1e-11 44.3 0.0 2.9 2 1 0 2 2 2 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 CRG90312.1 - 9.1e-06 25.8 0.0 0.00061 19.9 0.0 2.7 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Acetyltransf_8 PF13523.6 CRG90313.1 - 3.9e-48 162.8 0.0 5.9e-48 162.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 CRG90313.1 - 0.025 15.3 0.0 0.049 14.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF2570 PF10828.8 CRG90314.1 - 0.043 13.6 0.4 0.054 13.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) ABC_tran_CTD PF16326.5 CRG90314.1 - 0.13 12.5 1.7 0.6 10.4 0.3 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain Cyclin_N PF00134.23 CRG90315.1 - 1.7e-12 47.2 0.0 3.8e-12 46.1 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 CRG90315.1 - 3.5e-06 27.5 0.2 1e-05 26.0 0.0 1.9 2 0 0 2 2 2 1 Cyclin TSNAXIP1_N PF15739.5 CRG90315.1 - 0.012 16.0 0.5 0.021 15.2 0.5 1.3 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus DUF2076 PF09849.9 CRG90315.1 - 0.023 14.8 8.6 0.058 13.4 0.5 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Spt20 PF12090.8 CRG90315.1 - 0.035 13.7 2.8 0.063 12.9 2.8 1.5 1 0 0 1 1 1 0 Spt20 family ERG2_Sigma1R PF04622.12 CRG90316.1 - 1.9e-97 324.6 0.4 2.4e-97 324.4 0.4 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein DUF2929 PF11151.8 CRG90316.1 - 1.3 9.4 4.3 9.9 6.5 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2929) zn-ribbon_14 PF16503.5 CRG90317.1 - 2.3e-18 65.4 3.5 2.3e-18 65.4 3.5 3.6 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 CRG90317.1 - 3e-18 66.2 0.0 4.9e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 PP-loop family RecR PF02132.15 CRG90317.1 - 0.014 15.0 1.0 0.014 15.0 1.0 2.6 3 0 0 3 3 3 0 RecR protein tRNA_Me_trans PF03054.16 CRG90317.1 - 0.015 14.1 0.0 0.027 13.3 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase zf-UBR PF02207.20 CRG90317.1 - 0.53 10.5 5.2 11 6.3 0.5 2.5 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Complex1_LYR_2 PF13233.6 CRG90318.1 - 7.6e-22 77.9 1.5 9.1e-22 77.6 1.5 1.1 1 0 0 1 1 1 1 Complex1_LYR-like CHD5 PF04420.14 CRG90318.1 - 0.0061 16.4 0.3 0.0072 16.2 0.3 1.1 1 0 0 1 1 1 1 CHD5-like protein Complex1_LYR PF05347.15 CRG90318.1 - 0.04 14.0 2.8 0.089 12.9 2.7 1.7 1 1 0 1 1 1 0 Complex 1 protein (LYR family) RasGEF PF00617.19 CRG90319.1 - 4.7e-42 144.2 0.0 7.8e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 CRG90319.1 - 5.3e-14 52.3 0.1 1.1e-13 51.3 0.1 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif zf-HIT PF04438.16 CRG90319.1 - 4.5e-09 36.0 9.2 6.7e-09 35.5 9.2 1.3 1 0 0 1 1 1 1 HIT zinc finger SEFIR PF08357.11 CRG90319.1 - 0.17 12.2 0.0 2.8 8.2 0.0 2.3 2 0 0 2 2 2 0 SEFIR domain zf-B_box PF00643.24 CRG90319.1 - 9.9 6.4 8.0 17 5.7 8.0 1.3 1 0 0 1 1 1 0 B-box zinc finger Nfu_N PF08712.11 CRG90320.1 - 1e-29 102.4 0.0 4.1e-29 100.5 0.0 1.9 2 0 0 2 2 2 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 CRG90320.1 - 1.9e-28 98.4 0.1 3.2e-28 97.7 0.1 1.4 1 0 0 1 1 1 1 NifU-like domain PSP1 PF04468.12 CRG90321.1 - 2.1e-27 95.2 2.6 3.5e-27 94.5 2.6 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Ribosomal_L15e PF00827.17 CRG90322.1 - 1.3e-88 295.7 9.7 1.6e-88 295.4 9.7 1.0 1 0 0 1 1 1 1 Ribosomal L15 HECT PF00632.25 CRG90323.1 - 1.3e-74 251.5 0.0 1.7e-74 251.1 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RNA_pol_3_Rpc31 PF11705.8 CRG90323.1 - 0.057 13.7 0.2 0.11 12.8 0.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 ITAM_Cys-rich PF10538.9 CRG90323.1 - 1.7 8.5 3.6 0.94 9.3 0.6 2.0 2 0 0 2 2 2 0 Immunoreceptor tyrosine-based activation motif ADH_N PF08240.12 CRG90324.1 - 1.5e-35 121.4 2.5 2.9e-35 120.5 2.5 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG90324.1 - 2e-16 60.1 0.0 3.2e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG90324.1 - 1.1e-13 51.2 0.0 1.6e-13 50.7 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 CRG90324.1 - 5.3e-07 30.8 0.0 9e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 CRG90324.1 - 0.013 14.7 0.5 0.021 14.1 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain NADH_4Fe-4S PF10589.9 CRG90324.1 - 0.029 14.4 0.3 0.089 12.9 0.3 1.9 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region NAD_binding_7 PF13241.6 CRG90324.1 - 0.099 13.1 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CRG90324.1 - 0.14 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FRG1 PF06229.12 CRG90325.1 - 2.8e-56 190.2 0.8 3e-55 186.9 0.1 2.0 2 0 0 2 2 2 1 FRG1-like domain Fascin PF06268.13 CRG90325.1 - 0.095 12.9 0.0 0.27 11.4 0.0 1.8 2 0 0 2 2 2 0 Fascin domain ABA_WDS PF02496.16 CRG90325.1 - 0.13 12.7 1.3 0.23 12.0 0.1 1.9 2 0 0 2 2 2 0 ABA/WDS induced protein Lactamase_B_2 PF12706.7 CRG90326.1 - 1.3e-07 31.3 0.0 7.7e-07 28.8 0.0 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DRMBL PF07522.14 CRG90326.1 - 5e-06 26.7 0.3 2.8e-05 24.3 0.1 2.3 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B PF00753.27 CRG90326.1 - 0.00014 21.9 0.0 0.00035 20.6 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 CRG90326.1 - 0.0053 16.7 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain PHD_like PF12910.7 CRG90326.1 - 0.04 13.9 0.1 6.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system SDA1 PF05285.12 CRG90327.1 - 0.018 14.5 7.0 0.021 14.3 7.0 1.3 1 0 0 1 1 1 0 SDA1 VIR_N PF15912.5 CRG90327.1 - 0.06 12.9 3.5 0.12 12.0 3.5 1.6 1 0 0 1 1 1 0 Virilizer, N-terminal PBP1_TM PF14812.6 CRG90327.1 - 0.21 12.0 3.8 0.6 10.5 3.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Astro_capsid_p PF12226.8 CRG90327.1 - 0.29 10.2 6.4 0.4 9.8 6.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sigma70_ner PF04546.13 CRG90327.1 - 0.39 10.6 10.5 1.8 8.4 10.8 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.14 CRG90327.1 - 0.44 8.8 5.5 0.51 8.6 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein SGT1 PF07093.11 CRG90327.1 - 0.5 8.8 5.8 0.65 8.4 5.8 1.1 1 0 0 1 1 1 0 SGT1 protein Nop14 PF04147.12 CRG90327.1 - 1.2 7.3 12.7 1.4 7.0 12.7 1.1 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.5 CRG90327.1 - 1.6 8.4 5.4 2.8 7.7 5.4 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DNA_pol_phi PF04931.13 CRG90327.1 - 2.2 6.3 14.3 2.7 6.0 14.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 CRG90327.1 - 2.5 7.2 6.1 3.8 6.6 6.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PPP4R2 PF09184.11 CRG90327.1 - 4.8 6.7 13.7 7.5 6.0 13.7 1.3 1 0 0 1 1 1 0 PPP4R2 NPR2 PF06218.11 CRG90328.1 - 3.2e-134 448.0 0.0 2.2e-133 445.2 0.0 2.2 1 1 0 1 1 1 1 Nitrogen permease regulator 2 Ada3 PF10198.9 CRG90329.1 - 7.2e-52 175.0 1.4 9.9e-52 174.6 0.0 2.0 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 zf-RING_2 PF13639.6 CRG90330.1 - 4.6e-11 42.9 4.9 8.9e-11 41.9 4.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 CRG90330.1 - 6.5e-09 35.4 2.4 6.5e-09 35.4 2.4 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CRG90330.1 - 7.3e-07 28.9 5.4 1.4e-06 28.0 5.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG90330.1 - 4.3e-06 26.5 3.1 8.9e-06 25.5 3.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG90330.1 - 6.1e-05 22.9 3.6 0.00013 21.9 3.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 CRG90330.1 - 6.4e-05 22.9 1.8 6.4e-05 22.9 1.8 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 CRG90330.1 - 0.00056 20.2 5.1 0.0022 18.3 5.1 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain Otopetrin PF03189.13 CRG90330.1 - 0.00095 18.1 1.6 5 5.8 0.0 2.5 1 1 1 2 2 1 1 Otopetrin zf-C3HC4_3 PF13920.6 CRG90330.1 - 0.0015 18.3 2.7 0.0027 17.6 2.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG90330.1 - 0.0031 17.3 5.6 0.0072 16.2 5.7 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CRG90330.1 - 0.031 14.3 2.9 0.062 13.4 2.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CRG90330.1 - 0.096 12.3 2.6 0.19 11.4 2.6 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type CAF1 PF04857.20 CRG90330.1 - 0.12 11.5 15.0 2.6 7.1 15.6 2.2 1 1 0 1 1 1 0 CAF1 family ribonuclease zf-RING-like PF08746.11 CRG90330.1 - 0.13 12.5 4.4 0.11 12.8 2.0 2.1 2 0 0 2 2 2 0 RING-like domain LGT PF01790.18 CRG90330.1 - 0.19 10.9 0.0 0.39 9.9 0.0 1.5 1 1 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase Apt1 PF10351.9 CRG90330.1 - 0.54 9.0 39.5 0.0053 15.7 13.1 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 CRG90330.1 - 1 8.0 43.2 0.0049 15.7 25.7 2.6 2 0 0 2 2 2 0 Presenilin DUF853 PF05872.12 CRG90330.1 - 1.3 7.5 11.3 2.7 6.5 11.3 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Macoilin PF09726.9 CRG90330.1 - 2.5 6.6 35.2 0.037 12.6 12.9 2.2 2 0 0 2 2 2 0 Macoilin family DUF4381 PF14316.6 CRG90330.1 - 7.6 6.8 5.5 1 9.6 0.1 2.2 3 0 0 3 3 2 0 Domain of unknown function (DUF4381) DUF262 PF03235.14 CRG90330.1 - 8.1 6.6 20.5 22 5.1 20.5 1.7 1 0 0 1 1 1 0 Protein of unknown function DUF262 MFS_Mycoplasma PF07672.13 CRG90330.1 - 9.9 5.4 5.7 0.82 8.9 0.1 1.9 2 0 0 2 2 2 0 Mycoplasma MFS transporter Amidohydro_1 PF01979.20 CRG90331.1 - 2.2e-78 264.0 1.4 4.1e-78 263.1 1.4 1.4 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 CRG90331.1 - 2.3e-56 189.4 1.0 2.3e-56 189.4 1.0 1.9 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 CRG90331.1 - 1.9e-41 140.1 0.5 9.9e-41 137.7 0.1 2.1 2 0 0 2 2 2 1 Urease beta subunit Urease_gamma PF00547.18 CRG90331.1 - 2.2e-36 124.1 0.1 9.9e-36 122.0 0.0 2.1 2 0 0 2 2 2 1 Urease, gamma subunit HMG_box PF00505.19 CRG90331.1 - 6e-11 42.6 3.4 1.3e-10 41.5 3.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box Amidohydro_3 PF07969.11 CRG90331.1 - 6.3e-09 35.8 0.3 0.00014 21.5 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family HMG_box_2 PF09011.10 CRG90331.1 - 8e-05 23.2 1.9 0.00022 21.7 1.9 1.8 1 0 0 1 1 1 1 HMG-box domain AF-4 PF05110.13 CRG90331.1 - 0.0083 14.3 20.7 0.012 13.8 20.7 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein TP2 PF01254.18 CRG90331.1 - 0.47 11.1 11.5 1.2 9.8 11.5 1.6 1 0 0 1 1 1 0 Nuclear transition protein 2 DUF572 PF04502.13 CRG90331.1 - 1.7 8.2 19.7 2.8 7.5 19.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Hamartin PF04388.12 CRG90331.1 - 3 6.4 9.5 4.3 5.9 9.5 1.1 1 0 0 1 1 1 0 Hamartin protein LAP1C PF05609.12 CRG90331.1 - 4.9 6.1 11.6 7.7 5.5 11.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 CRG90331.1 - 5.6 5.1 12.5 8.5 4.5 12.5 1.2 1 0 0 1 1 1 0 CDC45-like protein NAD_binding_1 PF00175.21 CRG90332.1 - 2.1e-34 118.4 0.0 3.4e-34 117.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CRG90332.1 - 2.7e-24 85.4 0.0 1.2e-23 83.4 0.0 2.1 3 0 0 3 3 3 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CRG90332.1 - 5.2e-09 36.4 0.0 0.00016 21.9 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Ribosomal_L18A PF01775.17 CRG90333.1 - 2.6e-54 182.5 0.2 3.2e-54 182.2 0.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A PCI PF01399.27 CRG90334.1 - 9e-09 35.8 0.0 3.1e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 PCI domain ARID PF01388.21 CRG90334.1 - 0.059 14.1 0.2 1.3 9.8 0.0 2.5 2 1 0 2 2 2 0 ARID/BRIGHT DNA binding domain ANAPC3 PF12895.7 CRG90334.1 - 0.09 13.0 0.2 18 5.6 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 BTB PF00651.31 CRG90335.1 - 1.5e-06 28.4 0.2 1.3e-05 25.4 0.0 2.4 3 0 0 3 3 3 1 BTB/POZ domain DUF3112 PF11309.8 CRG90335.1 - 0.098 12.1 1.1 0.16 11.4 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) CLTH PF10607.9 CRG90336.1 - 1.1e-32 113.0 0.0 2.1e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 CRG90336.1 - 1.2e-08 34.8 0.4 2.3e-08 33.9 0.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Rtf2 PF04641.12 CRG90336.1 - 9.6e-05 21.9 0.0 0.00019 20.9 0.0 1.4 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_5 PF14634.6 CRG90336.1 - 0.00068 19.5 0.5 0.0012 18.8 0.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 CRG90336.1 - 0.001 19.3 0.7 0.0019 18.5 0.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG90336.1 - 0.0024 17.7 1.5 0.0046 16.8 1.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG90336.1 - 0.007 16.2 1.1 0.014 15.3 1.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 CRG90336.1 - 0.0094 15.8 1.2 0.018 14.9 1.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG90336.1 - 0.018 14.9 0.7 0.031 14.1 0.7 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Flagellin_C PF00700.21 CRG90336.1 - 0.071 13.5 0.1 0.16 12.3 0.1 1.6 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region zf-C3HC4_4 PF15227.6 CRG90336.1 - 0.095 12.9 1.2 0.2 11.9 1.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cast PF10174.9 CRG90337.1 - 0.0045 15.3 1.1 0.0069 14.7 1.1 1.2 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Nsp1_C PF05064.13 CRG90337.1 - 0.0054 16.5 1.7 0.0092 15.8 1.0 1.7 1 1 0 1 1 1 1 Nsp1-like C-terminal region PG_binding_1 PF01471.18 CRG90337.1 - 0.059 13.6 0.0 4.4 7.6 0.0 3.0 3 0 0 3 3 3 0 Putative peptidoglycan binding domain CLZ PF16526.5 CRG90337.1 - 0.063 13.6 2.9 3.6 8.0 0.1 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FlaC_arch PF05377.11 CRG90337.1 - 0.069 13.5 0.7 0.24 11.8 0.7 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) FPP PF05911.11 CRG90337.1 - 0.12 10.6 1.3 0.17 10.0 1.3 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Rab5-bind PF09311.11 CRG90337.1 - 0.13 11.6 3.6 0.23 10.8 3.6 1.3 1 0 0 1 1 1 0 Rabaptin-like protein Tropomyosin_1 PF12718.7 CRG90337.1 - 2.4 8.3 7.9 1.1 9.4 1.3 2.8 3 0 0 3 3 3 0 Tropomyosin like zf-Tim10_DDP PF02953.15 CRG90338.1 - 1.6e-21 75.7 1.8 1.9e-21 75.5 1.8 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger tRNA-synt_2 PF00152.20 CRG90339.1 - 2.3e-69 233.9 0.0 3e-69 233.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CRG90339.1 - 2.9e-09 36.8 0.0 6e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 CRG90339.1 - 1.7e-05 24.4 0.0 0.01 15.3 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 CRG90339.1 - 0.013 15.7 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain 2OG-FeII_Oxy PF03171.20 CRG90340.1 - 0.003 18.0 0.0 0.007 16.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG90340.1 - 0.025 15.3 0.0 0.045 14.5 0.0 1.4 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal Clr2 PF10383.9 CRG90341.1 - 3.2e-31 109.1 0.0 6.4e-31 108.1 0.0 1.5 1 0 0 1 1 1 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 CRG90341.1 - 4e-13 50.0 0.1 1e-12 48.7 0.1 1.7 1 0 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 ABC_membrane_2 PF06472.15 CRG90342.1 - 3.7e-89 298.7 0.1 3.7e-89 298.7 0.1 1.9 3 0 0 3 3 3 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 CRG90342.1 - 1.3e-12 48.4 0.0 2.8e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 CRG90342.1 - 0.054 14.0 0.5 7.7 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CRG90342.1 - 0.065 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CRG90342.1 - 0.17 11.6 0.1 0.67 9.7 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain NIF PF03031.18 CRG90343.1 - 1.2e-41 142.1 0.1 5.3e-39 133.5 0.1 2.3 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase LRR_4 PF12799.7 CRG90344.1 - 7.5e-35 118.4 30.1 1.8e-08 34.5 1.7 6.7 5 2 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG90344.1 - 3.1e-21 74.9 27.7 1.4e-07 31.2 4.1 6.5 4 3 2 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 CRG90344.1 - 1.3e-15 57.3 11.7 3e-06 26.9 1.5 4.1 1 1 3 4 4 4 4 Leucine-rich repeat LRR_6 PF13516.6 CRG90344.1 - 3.6e-05 23.5 24.0 0.28 11.3 0.3 7.9 9 0 0 9 9 9 4 Leucine Rich repeat LRR_1 PF00560.33 CRG90344.1 - 0.00021 21.4 24.9 4.5 8.2 0.1 8.7 9 1 0 9 9 9 2 Leucine Rich Repeat Aldo_ket_red PF00248.21 CRG90345.1 - 1.7e-41 142.3 0.0 2.5e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family adh_short PF00106.25 CRG90346.1 - 3.6e-37 127.7 0.6 8.2e-37 126.6 0.6 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90346.1 - 1.2e-28 100.3 0.4 2.1e-28 99.5 0.4 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90346.1 - 5.6e-13 49.2 0.1 8.9e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG90346.1 - 2.8e-06 27.0 0.1 5.5e-06 26.0 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG90346.1 - 0.0001 22.2 0.2 0.00035 20.5 0.2 1.9 2 1 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG90346.1 - 0.0011 19.2 0.2 0.0028 17.9 0.2 1.7 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain GDP_Man_Dehyd PF16363.5 CRG90346.1 - 0.0027 17.2 0.1 0.0052 16.2 0.1 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase DUF374 PF04028.13 CRG90346.1 - 0.15 11.6 0.1 0.5 10.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF374) TEA PF01285.18 CRG90347.1 - 5.9e-27 93.5 0.0 1.5e-26 92.3 0.0 1.7 1 0 0 1 1 1 1 TEA/ATTS domain RRM_1 PF00076.22 CRG90349.1 - 1.9e-70 232.7 0.3 3.8e-17 61.9 0.0 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 CRG90349.1 - 2.3e-05 24.0 0.0 0.0053 16.3 0.0 3.6 4 1 0 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 CRG90349.1 - 3.2e-05 23.9 0.1 1.1 9.3 0.0 4.7 4 0 0 4 4 4 1 Limkain b1 Nup35_RRM_2 PF14605.6 CRG90349.1 - 6.8e-05 22.8 0.0 4.5 7.4 0.0 4.7 5 0 0 5 5 5 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 CRG90349.1 - 0.00055 19.7 0.0 2.2 8.2 0.0 3.9 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_2 PF04059.12 CRG90349.1 - 0.006 16.8 0.0 1.4 9.2 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif 2 RRM_7 PF16367.5 CRG90349.1 - 0.021 15.0 0.0 26 5.0 0.0 3.7 3 0 0 3 3 3 0 RNA recognition motif Dynein_light PF01221.18 CRG90350.1 - 3.1e-28 97.9 1.0 4.1e-28 97.5 1.0 1.2 1 0 0 1 1 1 1 Dynein light chain type 1 zinc_ribbon_15 PF17032.5 CRG90350.1 - 0.001 19.8 2.6 0.002 18.9 2.6 1.4 1 0 0 1 1 1 1 zinc-ribbon family eIF-5_eIF-2B PF01873.17 CRG90350.1 - 0.49 10.3 2.3 0.89 9.5 2.3 1.5 1 1 0 1 1 1 0 Domain found in IF2B/IF5 NOB1_Zn_bind PF08772.11 CRG90350.1 - 0.88 9.8 5.0 1.3 9.2 0.3 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like F-box-like PF12937.7 CRG90351.1 - 0.0007 19.4 0.1 0.0016 18.3 0.1 1.6 1 0 0 1 1 1 1 F-box-like LIDHydrolase PF10230.9 CRG90352.1 - 2.8e-50 171.3 0.0 3.5e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 CRG90352.1 - 1.5e-06 28.1 0.0 2.4e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG90352.1 - 1.3e-05 25.9 0.0 2.1e-05 25.2 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family DUF900 PF05990.12 CRG90352.1 - 4.2e-05 23.2 0.0 6.1e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) PGAP1 PF07819.13 CRG90352.1 - 0.00059 19.6 0.0 0.00096 18.9 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein LCAT PF02450.15 CRG90352.1 - 0.01 15.1 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 CRG90352.1 - 0.01 15.1 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 CRG90352.1 - 0.012 15.4 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase Chlorophyllase2 PF12740.7 CRG90352.1 - 0.016 14.1 0.0 0.021 13.7 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme DUF676 PF05057.14 CRG90352.1 - 0.019 14.5 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 CRG90352.1 - 0.069 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF3089 PF11288.8 CRG90352.1 - 0.11 12.0 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF1749 PF08538.10 CRG90352.1 - 0.17 10.9 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) SSF PF00474.17 CRG90353.1 - 7.5e-17 61.3 33.8 1.1e-16 60.7 33.8 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family DUF5056 PF16479.5 CRG90353.1 - 3.9 7.8 8.2 5.6 7.3 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5056) Sec61_beta PF03911.16 CRG90354.1 - 1.7e-17 63.2 0.8 2.3e-17 62.8 0.8 1.2 1 0 0 1 1 1 1 Sec61beta family MIG-14_Wnt-bd PF06664.12 CRG90355.1 - 0.0036 16.6 3.6 0.0036 16.6 3.6 2.8 1 1 1 2 2 2 1 Wnt-binding factor required for Wnt secretion SCIMP PF15050.6 CRG90355.1 - 0.42 11.1 3.2 1 9.8 0.0 2.7 3 0 0 3 3 3 0 SCIMP protein Chordopox_A13L PF05961.11 CRG90355.1 - 0.66 10.3 3.2 14 6.0 1.0 3.3 3 0 0 3 3 3 0 Chordopoxvirus A13L protein Phtf-FEM1B_bdg PF12129.8 CRG90355.1 - 1.2 8.9 5.8 0.29 11.0 1.9 1.9 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor Zn_clus PF00172.18 CRG90356.1 - 8.5 6.6 14.4 13 6.0 14.4 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain adh_short PF00106.25 CRG90358.1 - 0.0027 17.2 0.0 0.0048 16.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90358.1 - 0.041 13.4 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Vezatin PF12632.7 CRG90360.1 - 7.1e-69 232.3 0.1 7.1e-69 232.3 0.1 1.5 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes PLDc_N PF13396.6 CRG90360.1 - 0.0048 16.8 0.8 0.0088 16.0 0.8 1.5 1 0 0 1 1 1 1 Phospholipase_D-nuclease N-terminal NOG1_N PF17835.1 CRG90360.1 - 0.9 9.5 4.7 0.67 9.9 2.3 2.1 2 0 0 2 2 2 0 NOG1 N-terminal helical domain DUF2457 PF10446.9 CRG90361.1 - 7.1e-138 460.6 36.1 7.1e-138 460.6 36.1 4.0 2 2 0 3 3 3 1 Protein of unknown function (DUF2457) Pes-10 PF07149.11 CRG90361.1 - 2.2 7.2 11.0 4.6 6.2 11.0 1.4 1 0 0 1 1 1 0 Pes-10 Arf PF00025.21 CRG90362.1 - 9.8e-60 201.0 0.0 1.4e-47 161.4 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 CRG90362.1 - 6.3e-11 42.0 0.0 3.9e-07 29.6 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CRG90362.1 - 9.8e-06 25.8 0.0 0.0092 16.2 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 CRG90362.1 - 3.1e-05 23.5 0.0 0.00014 21.4 0.0 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CRG90362.1 - 6.9e-05 22.9 0.0 0.00016 21.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 CRG90362.1 - 0.00018 21.2 0.0 0.0051 16.4 0.0 2.1 2 0 0 2 2 2 1 Ras family Gtr1_RagA PF04670.12 CRG90362.1 - 0.0076 15.6 0.0 0.068 12.5 0.0 2.0 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 CRG90362.1 - 0.18 11.4 0.0 0.86 9.1 0.0 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Metallophos PF00149.28 CRG90363.1 - 3.9e-40 138.5 0.1 5.2e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 CRG90363.1 - 1.2e-22 80.1 2.6 1.5e-22 79.8 1.7 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain LRR_4 PF12799.7 CRG90364.1 - 7.2e-14 51.7 4.5 0.00073 19.9 0.2 4.3 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG90364.1 - 1.1e-13 50.7 13.4 4.1e-08 32.9 3.2 4.2 3 1 2 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 CRG90364.1 - 3.3e-05 23.9 9.9 26 5.9 0.1 6.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 CRG90364.1 - 0.0057 16.2 0.4 0.061 12.8 0.6 2.2 1 1 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 CRG90364.1 - 0.026 14.6 13.3 0.74 10.0 0.4 5.0 5 0 0 5 5 5 0 Leucine Rich repeat DUF3336 PF11815.8 CRG90365.1 - 4.1e-51 172.3 3.0 6.6e-51 171.7 3.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 CRG90365.1 - 1.7e-17 64.3 0.8 4.5e-17 62.9 0.1 2.2 2 1 0 2 2 2 1 Patatin-like phospholipase TPR_19 PF14559.6 CRG90366.1 - 2.1e-16 60.2 20.0 2.8e-06 27.7 0.0 7.8 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 CRG90366.1 - 2.3e-13 49.6 5.6 0.033 13.9 0.1 7.3 5 2 2 7 7 7 3 TPR repeat TPR_17 PF13431.6 CRG90366.1 - 1.4e-12 47.1 2.6 0.029 14.8 0.1 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG90366.1 - 3e-12 45.7 17.0 0.22 11.8 0.3 8.3 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 CRG90366.1 - 1.4e-11 43.6 30.9 0.37 11.0 0.1 10.3 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_12 PF13424.6 CRG90366.1 - 1.1e-10 41.6 18.3 0.00064 20.0 0.2 7.1 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG90366.1 - 1.8e-10 40.8 25.5 0.0023 18.6 0.5 10.4 8 2 3 11 11 10 2 Tetratricopeptide repeat TPR_1 PF00515.28 CRG90366.1 - 3.5e-10 39.2 27.3 0.34 10.8 0.2 10.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_7 PF13176.6 CRG90366.1 - 8.1e-10 38.0 16.2 0.35 11.0 0.0 8.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 CRG90366.1 - 1e-08 35.7 28.7 9.1e-05 23.0 0.0 6.8 6 1 1 7 7 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG90366.1 - 1.2e-06 28.7 18.2 0.0088 16.3 0.6 6.7 6 1 1 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 CRG90366.1 - 7.2e-06 26.1 13.3 0.023 14.8 0.3 5.5 5 2 1 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 CRG90366.1 - 0.00015 22.2 18.1 9.7 7.1 0.1 8.4 8 0 0 8 8 8 0 Tetratricopeptide repeat RPN7 PF10602.9 CRG90366.1 - 0.0003 20.5 6.3 0.38 10.4 0.1 4.6 4 1 1 5 5 5 1 26S proteasome subunit RPN7 TPR_20 PF14561.6 CRG90366.1 - 0.00031 21.0 1.9 15 6.0 0.0 4.9 3 1 1 4 4 4 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 CRG90366.1 - 0.002 18.6 0.4 3.8 8.0 0.0 3.4 3 0 0 3 3 3 1 Alkyl sulfatase dimerisation ChAPs PF09295.10 CRG90366.1 - 0.0087 15.1 0.0 0.47 9.4 0.0 3.0 4 0 0 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) BTAD PF03704.17 CRG90366.1 - 0.093 13.2 6.3 0.16 12.4 0.2 3.8 3 1 2 5 5 4 0 Bacterial transcriptional activator domain DNA_pol_phi PF04931.13 CRG90366.1 - 0.23 9.5 2.3 0.35 8.9 2.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi TPR_10 PF13374.6 CRG90366.1 - 0.3 11.0 22.0 1.7 8.6 0.1 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat CDC45 PF02724.14 CRG90366.1 - 0.63 8.3 4.1 1.2 7.4 4.1 1.4 1 0 0 1 1 1 0 CDC45-like protein SAM_2 PF07647.17 CRG90367.1 - 6.2e-07 29.4 0.1 1.2e-06 28.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 CRG90367.1 - 0.0013 19.1 0.2 0.0027 18.1 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 CRG90367.1 - 0.11 12.7 0.2 0.27 11.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) MFS_1 PF07690.16 CRG90368.1 - 4.9e-28 98.1 14.1 4.9e-28 98.1 14.1 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily TRI12 PF06609.13 CRG90368.1 - 3.5e-12 45.6 16.0 5.3e-12 44.9 16.0 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3825 PF12873.7 CRG90368.1 - 0.076 12.5 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3825) Sulfate_transp PF00916.20 CRG90369.1 - 3.2e-108 361.9 20.4 4.1e-108 361.5 20.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 CRG90369.1 - 1.8e-06 27.5 0.0 3.9e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 STAS domain YdjM PF04307.14 CRG90369.1 - 0.57 9.5 6.9 1.5 8.1 6.9 1.8 1 1 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase MFS_MOT1 PF16983.5 CRG90369.1 - 0.64 10.4 17.2 0.096 13.1 5.8 3.1 2 2 0 2 2 2 0 Molybdate transporter of MFS superfamily DnaJ_C PF01556.18 CRG90370.1 - 3e-39 134.5 0.1 3.9e-39 134.1 0.1 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 CRG90370.1 - 7.7e-26 90.0 1.6 1.3e-25 89.3 1.6 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 CRG90370.1 - 1.8e-15 57.0 19.4 3.1e-15 56.3 19.4 1.4 1 0 0 1 1 1 1 DnaJ central domain DUF1356 PF07092.12 CRG90370.1 - 0.098 11.9 2.9 1.1 8.5 0.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1356) Anti-TRAP PF15777.5 CRG90370.1 - 0.59 10.1 17.6 0.05 13.6 3.1 2.9 1 1 2 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 CRG90370.1 - 1.2 9.1 10.0 0.9 9.6 2.9 2.4 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 CRG90370.1 - 1.7 8.7 7.7 2.5 8.2 2.1 2.2 2 0 0 2 2 2 0 zinc-ribbons DUF2614 PF11023.8 CRG90370.1 - 2.3 8.3 6.5 7.2 6.7 1.2 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain GFO_IDH_MocA PF01408.22 CRG90371.1 - 2.1e-26 93.1 0.6 3.2e-26 92.5 0.6 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 CRG90371.1 - 2e-16 60.0 0.0 4.7e-16 58.8 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 CRG90371.1 - 0.00078 19.9 0.1 0.0015 19.0 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sugar_tr PF00083.24 CRG90372.1 - 9.2e-134 446.7 23.4 1.1e-133 446.5 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG90372.1 - 7.8e-23 81.0 31.5 7.8e-23 81.0 31.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily SMRP1 PF15181.6 CRG90372.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 dCMP_cyt_deam_1 PF00383.23 CRG90373.1 - 1.3e-21 76.4 0.0 1.9e-21 75.9 0.0 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 CRG90373.1 - 2.7e-18 66.1 0.0 3.4e-18 65.7 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 CRG90373.1 - 0.00013 22.0 0.6 0.15 12.2 0.5 2.2 1 1 1 2 2 2 2 Bd3614-like deaminase APOBEC_N PF08210.11 CRG90373.1 - 0.0018 18.2 0.2 0.81 9.6 0.0 2.1 1 1 1 2 2 2 2 APOBEC-like N-terminal domain APOBEC2 PF18772.1 CRG90373.1 - 0.0032 17.5 0.2 0.13 12.3 0.2 2.0 1 1 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 CRG90373.1 - 0.012 15.8 0.7 0.73 9.9 0.1 2.1 1 1 1 2 2 2 0 Novel AID APOBEC clade 1 SNAD4 PF18750.1 CRG90373.1 - 0.02 15.0 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 URO-D PF01208.17 CRG90374.1 - 2.6e-129 431.3 0.0 2.9e-129 431.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) WD40 PF00400.32 CRG90375.1 - 0.00014 22.6 1.0 0.16 12.9 0.0 4.6 4 0 0 4 4 4 1 WD domain, G-beta repeat Lactonase PF10282.9 CRG90375.1 - 0.041 13.1 0.2 0.76 9.0 0.0 2.2 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller MNR PF15718.5 CRG90375.1 - 0.6 8.2 3.4 1.1 7.3 0.0 2.1 2 0 0 2 2 2 0 Protein moonraker Ribosomal_L10 PF00466.20 CRG90376.1 - 5.7e-22 77.7 0.2 1.8e-21 76.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 CRG90376.1 - 6.5e-22 77.3 0.4 1.4e-21 76.3 0.0 1.7 2 0 0 2 2 2 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 CRG90376.1 - 5.5e-18 65.3 7.2 5.5e-18 65.3 7.2 2.1 2 0 0 2 2 2 1 60s Acidic ribosomal protein YukC PF10140.9 CRG90376.1 - 0.13 11.0 0.0 0.56 9.0 0.0 1.8 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC Vps53_N PF04100.12 CRG90377.1 - 3.4e-108 362.0 5.8 3.4e-108 362.0 5.8 1.8 2 0 0 2 2 2 1 Vps53-like, N-terminal Vps54_N PF10475.9 CRG90377.1 - 7.4e-08 32.0 8.0 1.8e-07 30.7 8.0 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex RINT1_TIP1 PF04437.13 CRG90377.1 - 1.1e-05 24.5 1.9 1.1e-05 24.5 1.9 2.9 2 1 0 2 2 2 1 RINT-1 / TIP-1 family DUF2451 PF10474.9 CRG90377.1 - 3.6e-05 23.7 0.0 0.00012 22.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) COG2 PF06148.11 CRG90377.1 - 8.1e-05 22.7 3.9 8.1e-05 22.7 3.9 2.4 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 Zw10 PF06248.13 CRG90377.1 - 0.08 11.5 9.2 0.052 12.1 7.2 1.6 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 ArdA PF07275.11 CRG90377.1 - 0.12 12.9 0.8 2.5 8.7 0.0 2.8 2 1 0 2 2 2 0 Antirestriction protein (ArdA) DUF5339 PF17274.2 CRG90377.1 - 0.13 13.1 4.5 4.3 8.3 0.4 3.2 1 1 1 2 2 2 0 Family of unknown function (DUF5339) XhlA PF10779.9 CRG90377.1 - 0.16 12.2 5.6 0.049 13.8 1.5 2.4 2 0 0 2 2 2 0 Haemolysin XhlA DUF1515 PF07439.11 CRG90377.1 - 0.33 11.0 3.6 0.2 11.7 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) FapA PF03961.13 CRG90377.1 - 0.38 9.3 2.0 0.77 8.3 2.0 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A NBD94 PF16830.5 CRG90377.1 - 0.62 10.5 3.6 1.3 9.4 2.6 2.0 2 0 0 2 2 1 0 Nucleotide-Binding Domain 94 of RH APG6_N PF17675.1 CRG90377.1 - 1.5 9.4 7.5 3.2 8.3 6.4 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region Atg14 PF10186.9 CRG90377.1 - 2.8 7.0 12.1 0.54 9.3 8.1 1.7 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TAP_C PF03943.13 CRG90378.1 - 2.5e-15 55.8 2.6 5.7e-15 54.7 2.6 1.7 1 0 0 1 1 1 1 TAP C-terminal domain LRR_4 PF12799.7 CRG90378.1 - 2.4e-08 34.2 9.1 0.00025 21.4 2.5 3.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG90378.1 - 2.5e-06 27.1 2.6 4.7e-06 26.3 1.5 2.1 2 0 0 2 2 2 1 Leucine rich repeat LRR_9 PF14580.6 CRG90378.1 - 6.7e-06 25.7 0.5 1.5e-05 24.6 0.0 1.8 3 0 0 3 3 3 1 Leucine-rich repeat NTF2 PF02136.20 CRG90378.1 - 2.6e-05 24.8 0.0 7.7e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_6 PF13516.6 CRG90378.1 - 0.00022 21.0 0.4 0.069 13.2 0.0 3.4 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.33 CRG90378.1 - 0.0038 17.6 0.5 3.9 8.4 0.1 3.4 2 0 0 2 2 2 1 Leucine Rich Repeat UBA_4 PF14555.6 CRG90378.1 - 0.083 12.7 0.8 0.37 10.6 0.1 2.4 2 0 0 2 2 2 0 UBA-like domain COPIIcoated_ERV PF07970.12 CRG90379.1 - 1.4e-84 283.3 0.1 2e-84 282.9 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 CRG90379.1 - 5.9e-30 103.5 0.0 1.5e-29 102.2 0.0 1.7 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PH PF00169.29 CRG90380.1 - 2.2e-07 31.3 0.1 3.1e-06 27.6 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_9 PF15410.6 CRG90380.1 - 0.0026 18.1 0.0 0.0066 16.8 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain zf-C2H2 PF00096.26 CRG90381.1 - 1.4e-27 94.5 64.6 5.2e-06 26.6 0.2 11.7 11 1 1 12 12 12 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG90381.1 - 2.8e-18 65.0 63.9 0.019 15.8 0.1 11.3 11 0 0 11 11 11 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG90381.1 - 4.3e-13 49.0 53.5 0.00071 19.9 0.9 10.6 11 0 0 11 11 11 6 Zinc-finger double domain FOXP-CC PF16159.5 CRG90381.1 - 2.3e-05 24.9 36.0 1 10.1 0.0 9.7 5 2 5 10 10 10 2 FOXP coiled-coil domain GAGA PF09237.11 CRG90381.1 - 0.00073 19.3 0.7 0.00073 19.3 0.7 4.0 4 0 0 4 4 4 1 GAGA factor zf-H2C2_5 PF13909.6 CRG90381.1 - 0.0009 18.9 2.2 0.0009 18.9 2.2 9.4 9 1 0 9 9 8 2 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 CRG90381.1 - 0.0048 17.2 27.3 12 6.3 0.1 9.5 11 0 0 11 11 11 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 CRG90381.1 - 0.015 15.0 23.9 1.1 9.1 0.0 6.1 6 0 0 6 6 6 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 CRG90381.1 - 0.18 12.1 29.6 0.29 11.4 3.2 5.2 2 1 5 7 7 7 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 CRG90381.1 - 0.19 11.7 0.1 0.19 11.7 0.1 7.8 9 0 0 9 9 9 0 C2H2-type zinc finger Ogr_Delta PF04606.12 CRG90381.1 - 0.47 10.5 0.1 0.47 10.5 0.1 4.8 5 2 1 6 6 6 0 Ogr/Delta-like zinc finger RNA_pol_Rpb6 PF01192.22 CRG90382.1 - 1.3e-16 60.3 0.1 1.8e-16 59.8 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 MFS_1 PF07690.16 CRG90383.1 - 1.7e-12 47.0 53.8 5.2e-12 45.4 38.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 CRG90384.1 - 8.8e-09 35.6 0.0 1.2e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG90384.1 - 8.1e-08 32.3 0.0 1.2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG90384.1 - 4.9e-06 26.4 0.0 7.4e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 CRG90384.1 - 8.6e-05 22.9 0.0 0.00012 22.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG90384.1 - 0.0074 16.4 0.1 0.013 15.6 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ATG16 PF08614.11 CRG90385.1 - 0.013 15.8 0.9 0.013 15.8 0.9 1.8 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF2884 PF11101.8 CRG90386.1 - 0.0081 15.7 2.6 0.015 14.9 1.9 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2884) PCI PF01399.27 CRG90387.1 - 8.1e-11 42.4 4.3 3.3e-10 40.4 0.1 3.2 3 0 0 3 3 3 1 PCI domain G-gamma PF00631.22 CRG90388.1 - 2.5e-24 85.0 0.0 3e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 GGL domain FMN_dh PF01070.18 CRG90389.1 - 4e-101 338.5 0.0 5.6e-101 338.0 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 CRG90389.1 - 6.3e-21 74.3 0.0 1.4e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Zn_clus PF00172.18 CRG90389.1 - 1.6e-07 31.3 8.2 2.7e-07 30.6 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG90389.1 - 4.8e-06 25.8 0.0 7.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glu_synthase PF01645.17 CRG90389.1 - 0.00066 18.9 0.1 0.0011 18.3 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 CRG90389.1 - 0.0021 17.2 0.0 0.0038 16.3 0.0 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 CRG90389.1 - 0.004 16.6 0.1 0.0077 15.7 0.1 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase ThiG PF05690.14 CRG90389.1 - 0.028 13.7 0.0 0.84 8.9 0.0 2.4 2 0 0 2 2 2 0 Thiazole biosynthesis protein ThiG DHO_dh PF01180.21 CRG90389.1 - 0.21 10.8 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Sugar_tr PF00083.24 CRG90390.1 - 2.5e-102 343.1 28.0 2.9e-102 342.9 28.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG90390.1 - 2.8e-19 69.3 50.4 4.6e-19 68.6 18.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4381 PF14316.6 CRG90390.1 - 0.056 13.7 0.2 0.13 12.5 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Rdx PF10262.9 CRG90391.1 - 6.5e-31 106.3 0.0 1.5e-30 105.2 0.0 1.6 1 1 0 1 1 1 1 Rdx family PDEase_I PF00233.19 CRG90392.1 - 5.2e-68 229.3 0.0 8.1e-68 228.7 0.0 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase zf-HC5HC2H_2 PF13832.6 CRG90393.1 - 1.2e-20 73.7 0.3 1.2e-20 73.7 0.3 4.4 4 1 0 4 4 4 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 CRG90393.1 - 1.9e-18 66.5 1.0 1.9e-18 66.5 1.0 4.9 5 2 0 5 5 5 1 PHD-like zinc-binding domain BAH PF01426.18 CRG90393.1 - 3.6e-18 65.6 0.0 7.7e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 CRG90393.1 - 4.6e-11 42.4 48.4 6e-07 29.3 6.4 5.4 6 0 0 6 6 6 3 PHD-finger PHD_2 PF13831.6 CRG90393.1 - 2.2e-08 33.5 3.9 2.2e-08 33.5 3.9 4.7 5 0 0 5 5 5 1 PHD-finger GATA PF00320.27 CRG90393.1 - 0.0039 16.8 19.4 0.098 12.3 2.0 4.9 4 0 0 4 4 4 2 GATA zinc finger FYVE_2 PF02318.16 CRG90393.1 - 0.0044 17.2 0.8 0.0044 17.2 0.8 3.8 5 0 0 5 5 5 2 FYVE-type zinc finger C1_2 PF03107.16 CRG90393.1 - 0.025 14.9 0.4 0.025 14.9 0.4 5.8 6 0 0 6 6 6 0 C1 domain DEAD PF00270.29 CRG90394.1 - 2.3e-15 56.8 0.1 8e-15 55.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG90394.1 - 8.4e-08 32.4 0.0 3.1e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG90394.1 - 7.4e-07 29.5 0.0 3.6e-06 27.3 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 CRG90394.1 - 0.0077 16.8 0.0 0.034 14.7 0.0 2.2 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_22 PF13401.6 CRG90394.1 - 0.037 14.3 0.0 0.13 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain CDC27 PF09507.10 CRG90394.1 - 0.14 11.5 1.1 0.22 10.9 1.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Vps8 PF12816.7 CRG90396.1 - 1.7e-57 194.1 0.1 3.8e-55 186.5 0.0 2.5 2 0 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 CRG90396.1 - 3.2e-05 23.8 0.2 0.21 11.4 0.0 3.5 3 0 0 3 3 3 2 Region in Clathrin and VPS Ribosomal_S18 PF01084.20 CRG90396.1 - 0.04 14.1 0.1 0.23 11.7 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein S18 zf-RING_5 PF14634.6 CRG90396.1 - 0.052 13.5 0.3 0.052 13.5 0.3 2.0 2 0 0 2 2 2 0 zinc-RING finger domain Glyco_hydro_16 PF00722.21 CRG90397.1 - 1.8e-06 27.5 0.2 1.4e-05 24.7 0.2 2.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_transf_90 PF05686.12 CRG90398.1 - 3.7e-11 42.6 0.1 6.2e-10 38.5 0.1 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_transf_90 PF05686.12 CRG90399.1 - 0.037 12.9 0.0 0.1 11.5 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferase family 90 GMC_oxred_N PF00732.19 CRG90400.1 - 5e-33 114.7 0.0 1.8e-15 57.1 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG90400.1 - 5.7e-15 56.1 0.2 9.7e-15 55.3 0.2 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GNAT_acetyltr_2 PF13718.6 CRG90401.1 - 9.7e-99 329.4 0.0 1.8e-98 328.5 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 CRG90401.1 - 3.2e-92 308.5 0.0 5.8e-92 307.7 0.0 1.4 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 CRG90401.1 - 4.1e-65 218.9 0.0 1.3e-64 217.3 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 CRG90401.1 - 3.2e-33 113.5 0.0 9.5e-33 112.0 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 CRG90401.1 - 0.0024 17.6 0.2 0.14 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Acetyltransf_1 PF00583.25 CRG90401.1 - 0.038 14.2 0.0 0.26 11.6 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family AAA_19 PF13245.6 CRG90401.1 - 0.063 13.6 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain Thioredoxin PF00085.20 CRG90402.1 - 5.5e-33 113.0 0.1 1.8e-27 95.3 0.1 2.4 2 0 0 2 2 2 2 Thioredoxin OST3_OST6 PF04756.13 CRG90402.1 - 5.4e-08 32.5 0.0 4.7e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 CRG90402.1 - 9e-08 32.5 0.6 0.0037 17.7 0.1 2.5 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 CRG90402.1 - 0.002 18.3 0.0 0.0043 17.2 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 CRG90402.1 - 0.0022 18.3 0.0 0.43 10.9 0.0 3.1 2 1 1 3 3 3 1 Thioredoxin-like AhpC-TSA PF00578.21 CRG90402.1 - 0.01 15.7 0.0 0.026 14.5 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_3 PF13192.6 CRG90402.1 - 0.02 14.9 0.0 1.3 9.2 0.1 2.5 2 0 0 2 2 2 0 Thioredoxin domain ERp29_N PF07912.13 CRG90402.1 - 0.026 14.7 0.0 0.062 13.5 0.0 1.6 1 0 0 1 1 1 0 ERp29, N-terminal domain Pap_E4 PF02711.14 CRG90402.1 - 0.039 14.9 2.9 0.039 14.9 2.9 2.2 2 0 0 2 2 2 0 E4 protein TraF PF13728.6 CRG90402.1 - 0.08 12.7 0.0 0.08 12.7 0.0 3.4 3 1 0 3 3 3 0 F plasmid transfer operon protein F-box-like PF12937.7 CRG90403.1 - 1.3e-07 31.4 2.0 4.6e-07 29.6 0.1 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 CRG90403.1 - 5.7e-07 29.3 0.0 2e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 F-box domain ATP-synt PF00231.19 CRG90404.1 - 3.6e-75 253.3 9.8 6.3e-75 252.5 9.8 1.4 1 0 0 1 1 1 1 ATP synthase DnaJ PF00226.31 CRG90404.1 - 1.8e-15 56.8 1.8 5.9e-15 55.2 1.8 1.9 1 0 0 1 1 1 1 DnaJ domain Neuregulin PF02158.15 CRG90404.1 - 1.1 8.5 7.6 1.9 7.7 7.6 1.3 1 0 0 1 1 1 0 Neuregulin intracellular region Topoisom_I_N PF02919.15 CRG90405.1 - 9.4e-97 322.7 4.1 9.4e-97 322.7 4.1 3.2 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 CRG90405.1 - 8.8e-96 319.6 4.6 8.8e-96 319.6 4.6 2.3 3 1 0 3 3 3 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 CRG90405.1 - 2.7e-34 116.9 1.2 1e-33 115.1 1.2 2.1 1 0 0 1 1 1 1 C-terminal topoisomerase domain DASH_Hsk3 PF08227.11 CRG90405.1 - 0.28 11.6 1.1 1 9.8 0.7 2.0 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like PNK3P PF08645.11 CRG90405.1 - 0.29 10.8 3.9 7.3 6.3 0.0 3.2 3 0 0 3 3 3 0 Polynucleotide kinase 3 phosphatase Epimerase PF01370.21 CRG90406.1 - 3.9e-18 65.8 0.0 7e-18 65.0 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG90406.1 - 1.8e-07 30.4 0.0 3.4e-06 26.3 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG90406.1 - 4.1e-05 23.1 0.0 0.00015 21.3 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CRG90406.1 - 0.00036 20.0 0.0 0.0019 17.7 0.0 2.1 2 1 0 2 2 2 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG90406.1 - 0.00092 19.5 0.0 0.0037 17.5 0.0 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 CRG90406.1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.5 2 0 0 2 2 2 0 KR domain Ldh_1_N PF00056.23 CRG90406.1 - 0.02 15.0 0.0 0.054 13.6 0.0 1.7 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Carbpep_Y_N PF05388.11 CRG90406.1 - 0.11 13.0 0.7 0.23 12.0 0.7 1.5 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide Aldedh PF00171.22 CRG90407.1 - 1.4e-130 435.9 0.0 2e-130 435.4 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CRG90407.1 - 2.9e-06 26.6 0.0 7.6e-06 25.2 0.0 1.7 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Fungal_trans PF04082.18 CRG90408.1 - 1.8e-12 46.9 2.9 2.8e-12 46.2 2.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2_4 PF13894.6 CRG90408.1 - 0.011 16.5 1.4 0.061 14.2 1.4 2.4 1 0 0 1 1 1 0 C2H2-type zinc finger Zn_clus PF00172.18 CRG90408.1 - 0.018 15.1 11.1 0.018 15.1 11.1 1.9 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 CRG90408.1 - 0.024 15.1 0.3 0.068 13.7 0.3 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type Vta1 PF04652.16 CRG90409.1 - 3.4e-55 186.0 0.2 3.4e-55 186.0 0.2 2.2 3 0 0 3 3 3 1 Vta1 like Peptidase_C2 PF00648.21 CRG90409.1 - 1.9e-31 109.2 0.0 3.2e-31 108.4 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease Vta1_C PF18097.1 CRG90409.1 - 6.5e-17 60.9 0.3 1.6e-16 59.7 0.3 1.7 1 0 0 1 1 1 1 Vta1 C-terminal domain Calpain_III PF01067.22 CRG90409.1 - 5.8e-07 29.9 0.0 6.5e-05 23.2 0.1 3.3 2 1 0 2 2 2 1 Calpain large subunit, domain III MIT PF04212.18 CRG90409.1 - 0.1 12.7 4.3 0.23 11.5 4.3 1.7 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Mito_carr PF00153.27 CRG90410.1 - 8.7e-55 182.6 0.9 2.4e-19 69.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein SNase PF00565.17 CRG90411.1 - 4.5e-23 81.8 0.0 6.5e-23 81.3 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue ADK PF00406.22 CRG90412.1 - 5.7e-36 123.9 0.0 1.6e-19 70.5 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 CRG90412.1 - 6.3e-15 54.9 0.0 9.8e-15 54.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 CRG90412.1 - 9.4e-14 52.0 0.0 6.8e-09 36.3 0.0 2.5 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 CRG90412.1 - 0.00053 20.5 0.0 0.02 15.4 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_33 PF13671.6 CRG90412.1 - 0.0018 18.5 0.0 0.019 15.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CRG90412.1 - 0.069 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 CRG90412.1 - 0.076 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG90412.1 - 0.15 12.0 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MeaB PF03308.16 CRG90412.1 - 0.19 10.6 0.1 0.3 10.0 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB DNA_primase_lrg PF04104.14 CRG90413.1 - 4.5e-85 285.3 0.0 7.2e-85 284.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Sec23_trunk PF04811.15 CRG90414.1 - 3e-80 269.3 0.0 4.5e-80 268.7 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 CRG90414.1 - 2.4e-29 101.9 0.0 5e-29 100.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 CRG90414.1 - 3.5e-24 84.6 0.0 8.2e-24 83.4 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 CRG90414.1 - 1.3e-14 53.9 3.7 2.4e-14 53.1 3.7 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 CRG90414.1 - 2.4e-10 40.1 0.0 7.1e-10 38.7 0.0 1.8 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 CRG90414.1 - 0.011 15.1 0.2 0.022 14.1 0.2 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Ribosomal_L11_N PF03946.14 CRG90415.1 - 6.1e-24 83.6 0.2 9.7e-24 83.0 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 CRG90415.1 - 1.7e-14 54.1 0.1 3e-14 53.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Glyco_transf_41 PF13844.6 CRG90416.1 - 8.2e-104 347.6 0.0 3.9e-52 177.2 0.0 3.2 1 1 0 2 2 2 2 Glycosyl transferase family 41 TPR_1 PF00515.28 CRG90416.1 - 5.3e-19 67.2 10.7 4.9e-05 23.0 0.0 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 CRG90416.1 - 3e-16 58.2 11.7 0.0086 16.1 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 CRG90416.1 - 6.4e-15 54.6 12.9 6.9e-05 22.5 0.2 6.4 3 2 3 6 6 6 4 TPR repeat TPR_8 PF13181.6 CRG90416.1 - 5.4e-12 44.9 3.6 4.1e-05 23.4 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG90416.1 - 2e-09 37.8 5.7 0.02 15.4 0.6 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG90416.1 - 7.9e-09 35.6 6.7 0.018 15.8 0.0 5.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CRG90416.1 - 1.6e-08 35.0 12.2 0.0089 16.7 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 CRG90416.1 - 2.1e-08 34.0 6.1 0.0097 16.2 0.2 5.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG90416.1 - 4.1e-08 32.8 15.0 0.055 13.3 0.0 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 CRG90416.1 - 1.7e-07 31.4 13.0 0.02 15.2 0.3 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG90416.1 - 3.5e-05 23.5 5.3 0.6 10.3 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG90416.1 - 0.007 16.5 4.2 0.13 12.4 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 CRG90416.1 - 0.039 14.4 0.1 3.4 8.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_15 PF13429.6 CRG90416.1 - 0.042 13.1 0.1 1.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Olduvai PF06758.13 CRG90416.1 - 0.056 13.7 0.9 0.38 11.1 0.6 2.6 2 0 0 2 2 1 0 Olduvai domain ANAPC3 PF12895.7 CRG90416.1 - 0.11 12.7 3.4 0.58 10.4 0.2 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CRG90416.1 - 4.6 8.1 6.4 1.9e+02 3.0 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat RVT_1 PF00078.27 CRG90417.1 - 2.6e-38 131.7 0.0 4.9e-38 130.9 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 CRG90417.1 - 3.4e-23 81.7 0.9 9.3e-23 80.3 0.9 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 CRG90417.1 - 1.4e-11 44.8 0.0 4.4e-11 43.1 0.0 1.9 1 0 0 1 1 1 1 RNase H Exo_endo_phos PF03372.23 CRG90417.1 - 2.6e-10 40.2 0.5 7e-10 38.8 0.5 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-C2H2 PF00096.26 CRG90417.1 - 0.0049 17.3 2.2 0.0058 17.0 0.2 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG90417.1 - 0.0098 16.7 0.3 0.085 13.7 0.3 2.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CRG90417.1 - 0.31 11.4 1.9 0.83 10.0 1.9 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Glyco_hydro_10 PF00331.20 CRG90418.1 - 7e-102 340.8 0.0 8.2e-102 340.6 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 Glyco_hydro_42 PF02449.15 CRG90418.1 - 0.029 13.7 0.1 0.08 12.3 0.1 1.7 1 1 1 2 2 2 0 Beta-galactosidase Beta-prism_lec PF16458.5 CRG90418.1 - 0.056 13.4 0.1 0.12 12.4 0.1 1.5 1 0 0 1 1 1 0 Beta-prism lectin Peptidase_S9 PF00326.21 CRG90419.1 - 1.4e-06 28.0 0.1 2.2e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 CRG90419.1 - 6.7e-05 22.7 1.4 0.00091 18.9 1.4 2.0 1 1 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 CRG90419.1 - 0.00014 21.4 0.1 0.00025 20.6 0.1 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_2 PF02230.16 CRG90419.1 - 0.00035 20.4 0.4 0.00057 19.8 0.0 1.5 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 CRG90419.1 - 0.016 14.8 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Rhomboid_SP PF12595.8 CRG90419.1 - 0.055 12.8 0.0 0.093 12.1 0.0 1.2 1 0 0 1 1 1 0 Rhomboid serine protease AXE1 PF05448.12 CRG90419.1 - 0.16 10.6 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) p450 PF00067.22 CRG90420.1 - 1.5e-51 175.6 0.0 2e-51 175.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 CH PF00307.31 CRG90421.1 - 2.6e-74 246.4 0.0 3.9e-20 72.1 0.1 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 CRG90421.1 - 1.7e-05 25.2 2.1 0.0002 21.7 0.6 3.1 3 0 0 3 3 3 1 EF-hand domain pair CAMSAP_CH PF11971.8 CRG90421.1 - 0.00062 19.5 0.0 0.4 10.5 0.0 3.5 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_1 PF00036.32 CRG90421.1 - 0.018 14.5 5.5 5.7 6.7 0.1 4.2 4 0 0 4 4 4 0 EF hand EF-hand_6 PF13405.6 CRG90421.1 - 0.022 14.7 3.2 0.7 10.0 0.1 3.5 3 0 0 3 3 3 0 EF-hand domain DDHD PF02862.17 CRG90422.1 - 3.7e-54 184.3 0.0 3.7e-54 184.3 0.0 4.2 4 1 0 4 4 4 1 DDHD domain PXA PF02194.15 CRG90422.1 - 1.9e-34 119.3 0.1 4.1e-34 118.2 0.1 1.6 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 CRG90422.1 - 3.6e-19 69.4 0.0 1.6e-18 67.3 0.0 2.3 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 CRG90422.1 - 0.00076 19.4 0.2 0.0072 16.3 0.1 2.4 2 0 0 2 2 2 1 PX domain PC4 PF02229.16 CRG90423.1 - 5.7e-25 86.7 0.0 1.8e-24 85.1 0.0 1.8 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) Myc_N PF01056.18 CRG90423.1 - 7 6.4 10.5 12 5.7 10.4 1.5 1 1 1 2 2 2 0 Myc amino-terminal region Hydantoinase_B PF02538.14 CRG90424.1 - 5e-223 741.2 0.1 6.8e-223 740.7 0.1 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CRG90424.1 - 2.1e-102 342.3 0.9 4.1e-102 341.4 0.9 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CRG90424.1 - 5.7e-61 205.3 0.1 4.6e-59 199.1 0.0 2.6 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Creatininase PF02633.14 CRG90424.1 - 0.089 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Creatinine amidohydrolase MIT PF04212.18 CRG90425.1 - 2.5e-14 53.1 1.3 5.8e-14 51.9 1.3 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain MukE PF04288.13 CRG90425.1 - 0.018 14.0 0.1 0.034 13.1 0.1 1.4 1 0 0 1 1 1 0 MukE-like family ELH PF02323.15 CRG90425.1 - 0.024 14.0 0.4 0.024 14.0 0.4 1.9 2 0 0 2 2 2 0 Egg-laying hormone precursor TP_methylase PF00590.20 CRG90425.1 - 0.13 12.2 0.8 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 Tetrapyrrole (Corrin/Porphyrin) Methylases COPI_C PF06957.11 CRG90425.1 - 0.39 9.4 2.5 11 4.7 0.0 2.1 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus Smac_DIABLO PF09057.10 CRG90425.1 - 2.1 7.7 4.8 7.8 5.8 4.8 1.9 1 1 0 1 1 1 0 Second Mitochondria-derived Activator of Caspases Peptidase_M24 PF00557.24 CRG90427.1 - 4.3e-53 180.1 0.0 6.3e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 CRG90427.1 - 2.1e-24 85.6 0.0 4e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain DUF3793 PF12672.7 CRG90427.1 - 0.16 12.0 0.0 0.39 10.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) Peptidase_M1 PF01433.20 CRG90428.1 - 3.2e-45 154.3 0.2 4.7e-45 153.8 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 CRG90428.1 - 1e-36 125.5 0.0 2.4e-36 124.2 0.0 1.7 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 CRG90428.1 - 4.6e-29 101.9 0.7 7.5e-29 101.2 0.7 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 CRG90428.1 - 0.26 11.7 2.8 4.4 7.7 2.8 2.6 1 1 0 1 1 1 0 M61 glycyl aminopeptidase TIP41 PF04176.13 CRG90429.1 - 1.5e-69 232.9 0.0 2.3e-69 232.3 0.0 1.3 1 0 0 1 1 1 1 TIP41-like family Ubiq_cyt_C_chap PF03981.12 CRG90429.1 - 2.8e-37 127.9 0.1 6.9e-37 126.7 0.1 1.7 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone EccE PF11203.8 CRG90429.1 - 0.23 11.8 0.9 20 5.6 0.0 2.6 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE Pkinase PF00069.25 CRG90430.1 - 4.4e-71 239.3 0.0 6.5e-71 238.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG90430.1 - 7.6e-44 149.9 0.0 1e-43 149.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG90430.1 - 1.3e-07 31.3 0.0 3.2e-07 30.0 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CRG90430.1 - 0.00055 19.3 0.2 0.00097 18.5 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CRG90430.1 - 0.008 15.2 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 CRG90430.1 - 0.017 14.7 0.0 0.037 13.6 0.0 1.5 1 1 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 CRG90430.1 - 0.031 13.8 0.2 0.071 12.6 0.0 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 CRG90430.1 - 0.042 13.5 0.1 0.16 11.6 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 CRG90430.1 - 0.066 12.0 0.0 0.073 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 CRG90430.1 - 0.13 12.1 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M76 PF09768.9 CRG90431.1 - 1.9e-74 249.1 4.4 2.3e-74 248.8 4.4 1.1 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M91 PF14891.6 CRG90431.1 - 0.032 14.6 0.8 0.058 13.7 0.8 1.5 1 1 0 1 1 1 0 Effector protein SprT-like PF10263.9 CRG90431.1 - 0.22 11.4 4.3 0.11 12.4 1.6 1.7 1 1 1 2 2 2 0 SprT-like family AA_kinase PF00696.28 CRG90432.1 - 7.2e-41 140.4 1.0 1.1e-40 139.7 1.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 CRG90432.1 - 1.4e-14 53.8 0.3 5.6e-14 51.9 0.0 2.1 2 0 0 2 2 2 1 PUA domain GPI-anchored PF10342.9 CRG90433.1 - 6.5e-16 58.9 0.2 1.4e-15 57.8 0.0 1.7 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family KRE9 PF05390.11 CRG90433.1 - 2e-13 50.9 8.9 2e-13 50.9 8.9 1.8 2 0 0 2 2 2 1 Yeast cell wall synthesis protein KRE9/KNH1 SRPRB PF09439.10 CRG90434.1 - 1.7e-23 83.0 0.9 3.2e-22 78.8 0.9 2.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 CRG90434.1 - 0.00052 19.5 0.2 0.012 15.0 0.1 2.6 2 1 0 2 2 2 1 ADP-ribosylation factor family AAA_16 PF13191.6 CRG90434.1 - 0.00077 19.9 0.1 0.0023 18.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 CRG90434.1 - 0.016 15.1 0.1 0.033 14.1 0.0 1.5 2 0 0 2 2 1 0 ATPase domain predominantly from Archaea AAA_21 PF13304.6 CRG90434.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 CRG90434.1 - 0.031 14.5 0.0 0.074 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 CRG90434.1 - 0.045 13.5 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 CRG90434.1 - 0.046 13.7 0.0 0.12 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 CRG90434.1 - 0.052 13.5 0.2 0.58 10.0 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 CRG90434.1 - 0.052 13.5 0.0 0.66 9.9 0.0 2.2 2 0 0 2 2 2 0 NACHT domain KAP_NTPase PF07693.14 CRG90434.1 - 0.056 12.7 0.2 0.078 12.2 0.2 1.3 1 1 0 1 1 1 0 KAP family P-loop domain ABC_tran PF00005.27 CRG90434.1 - 0.083 13.4 0.0 0.18 12.4 0.0 1.8 1 1 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 CRG90434.1 - 0.09 12.5 0.1 11 5.7 0.0 2.4 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA PF00004.29 CRG90434.1 - 0.1 13.0 0.1 0.28 11.6 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 CRG90434.1 - 0.13 11.9 0.0 1 9.0 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Septin PF00735.18 CRG90434.1 - 0.17 11.1 0.0 0.81 8.9 0.0 1.9 2 0 0 2 2 2 0 Septin PALP PF00291.25 CRG90435.1 - 3.4e-66 223.7 0.1 4.2e-66 223.4 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 CRG90435.1 - 1.3e-12 48.0 0.0 7.4e-09 35.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain 3Beta_HSD PF01073.19 CRG90436.1 - 3e-18 65.8 0.0 1.7e-17 63.4 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG90436.1 - 2.1e-15 56.9 0.1 1.2e-14 54.4 0.1 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG90436.1 - 2.2e-11 44.0 0.0 5e-11 42.8 0.0 1.6 2 0 0 2 2 2 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG90436.1 - 5.5e-09 35.9 0.0 8.2e-09 35.3 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG90436.1 - 1.9e-08 33.8 0.0 7.7e-07 28.5 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 CRG90436.1 - 5.3e-07 29.4 0.1 5.4e-05 22.9 0.2 2.1 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 CRG90436.1 - 7e-07 28.7 0.1 9.6e-07 28.2 0.1 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CRG90436.1 - 0.00028 20.4 0.1 0.00045 19.7 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CRG90436.1 - 0.0015 17.7 0.0 0.088 11.9 0.0 2.1 2 0 0 2 2 2 1 RmlD substrate binding domain KR PF08659.10 CRG90436.1 - 0.003 17.5 0.8 0.022 14.7 0.8 2.1 1 1 0 1 1 1 1 KR domain Cyclin PF08613.11 CRG90438.1 - 4.5e-39 134.4 0.0 7e-39 133.8 0.0 1.4 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CRG90438.1 - 0.039 13.7 0.1 0.06 13.1 0.1 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain Ank_2 PF12796.7 CRG90439.1 - 7.1e-36 122.7 0.0 2.1e-11 44.2 0.0 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) DHHC PF01529.20 CRG90439.1 - 1.2e-33 116.1 13.5 1.2e-33 116.1 13.5 2.4 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.6 CRG90439.1 - 1.7e-24 85.5 1.6 5.3e-07 29.8 0.0 4.8 1 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG90439.1 - 9.3e-23 77.9 2.5 4.2e-07 29.8 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 CRG90439.1 - 9.8e-22 76.4 1.1 3.6e-06 27.2 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 CRG90439.1 - 1.1e-17 64.1 1.5 0.00014 22.4 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) K_oxygenase PF13434.6 CRG90440.1 - 9.7e-112 373.5 0.0 1.2e-111 373.2 0.0 1.1 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CRG90440.1 - 2.4e-07 30.3 0.0 0.00044 19.6 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90440.1 - 4.7e-05 23.4 1.0 0.03 14.3 0.1 3.5 2 2 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG90440.1 - 8.5e-05 22.0 0.0 0.014 14.6 0.0 2.9 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AMP-binding PF00501.28 CRG90441.1 - 2.7e-233 774.1 0.0 8.2e-81 271.8 0.0 3.4 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 CRG90441.1 - 2.7e-187 623.0 0.0 6.9e-39 133.8 0.0 6.5 6 0 0 6 6 6 6 Condensation domain PP-binding PF00550.25 CRG90441.1 - 7.7e-58 192.7 16.1 1.2e-10 41.5 0.3 7.0 6 0 0 6 6 6 6 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG90441.1 - 3.1e-13 50.5 0.1 0.0089 17.0 0.0 3.7 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Flu_C_NS1 PF03506.13 CRG90441.1 - 0.0043 17.1 0.0 0.053 13.5 0.0 2.8 3 0 0 3 3 3 1 Influenza C non-structural protein (NS1) Transferase PF02458.15 CRG90441.1 - 0.0098 14.6 0.0 12 4.4 0.0 4.3 5 0 0 5 5 5 1 Transferase family Pkinase PF00069.25 CRG90442.1 - 4.6e-44 150.8 0.0 2.7e-42 145.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG90442.1 - 1.3e-25 90.1 0.0 2.3e-25 89.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CRG90442.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family OB_NTP_bind PF07717.16 CRG90443.1 - 1.1e-20 73.8 0.0 2.3e-20 72.7 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 CRG90443.1 - 2.1e-19 69.8 0.0 2.1e-19 69.8 0.0 4.3 4 1 0 4 4 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 CRG90443.1 - 4.3e-13 49.6 0.0 9.6e-13 48.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 CRG90443.1 - 1.3e-06 28.3 0.1 3.1e-06 27.1 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CRG90443.1 - 8.8e-05 22.8 0.8 0.00031 21.0 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CRG90443.1 - 0.0015 18.3 0.1 0.0035 17.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 CRG90443.1 - 0.0026 16.9 0.0 0.0059 15.7 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 CRG90443.1 - 0.0032 17.8 0.2 0.0073 16.7 0.2 1.6 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 CRG90443.1 - 0.005 16.5 0.3 0.019 14.6 0.2 2.0 2 1 0 2 2 2 1 SRP54-type protein, GTPase domain Sigma54_activ_2 PF14532.6 CRG90443.1 - 0.05 13.7 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_23 PF13476.6 CRG90443.1 - 0.056 13.9 0.0 0.056 13.9 0.0 3.7 1 1 2 3 3 1 0 AAA domain AAA_7 PF12775.7 CRG90443.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 CRG90443.1 - 0.22 12.0 0.6 1.1 9.8 0.1 2.4 1 1 1 2 2 2 0 ABC transporter Cyt-b5 PF00173.28 CRG90444.1 - 4.9e-22 77.9 0.2 5.4e-22 77.7 0.2 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain V-ATPase_H_C PF11698.8 CRG90444.1 - 0.054 13.6 0.0 0.091 12.9 0.0 1.4 1 1 0 1 1 1 0 V-ATPase subunit H BRX PF08381.11 CRG90444.1 - 0.072 12.5 0.7 0.69 9.3 0.7 2.4 1 1 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 EFP_N PF08207.12 CRG90444.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain Zip PF02535.22 CRG90445.1 - 9.5e-60 202.6 0.2 2.1e-59 201.4 0.2 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter Acetyltransf_1 PF00583.25 CRG90446.1 - 3.9e-11 43.2 0.0 8e-11 42.2 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG90446.1 - 9.4e-10 38.8 0.2 2.7e-09 37.3 0.2 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG90446.1 - 1.3e-09 38.0 0.0 2.7e-09 37.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 CRG90446.1 - 3.5e-06 27.1 0.0 6.9e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG90446.1 - 0.0087 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Mcp5_PH PF12814.7 CRG90447.1 - 1.4e-46 157.6 0.2 2.6e-46 156.7 0.2 1.5 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Fez1 PF06818.15 CRG90447.1 - 1.8e-06 28.6 18.4 1.8e-06 28.6 18.4 1.7 1 1 0 1 1 1 1 Fez1 DUF724 PF05266.14 CRG90447.1 - 0.0012 18.7 7.3 0.0023 17.8 7.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 CRG90447.1 - 0.007 16.4 24.6 0.23 11.5 12.6 2.5 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 CRG90447.1 - 0.023 14.8 11.8 0.052 13.6 11.8 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CorA PF01544.18 CRG90447.1 - 0.054 12.8 4.3 0.098 12.0 4.3 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ERM PF00769.19 CRG90447.1 - 0.073 12.9 19.1 0.16 11.8 19.1 1.6 1 0 0 1 1 1 0 Ezrin/radixin/moesin family GAS PF13851.6 CRG90447.1 - 0.51 9.7 28.5 5.4 6.3 28.5 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 CRG90447.1 - 0.52 9.8 8.6 0.99 8.9 8.6 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADIP PF11559.8 CRG90447.1 - 0.87 9.7 23.6 3 7.9 7.3 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding HIP1_clath_bdg PF16515.5 CRG90447.1 - 1.3 9.7 17.0 0.14 12.8 4.7 2.7 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fib_alpha PF08702.10 CRG90447.1 - 9 6.5 8.4 18 5.5 2.5 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family MSL1_dimer PF16801.5 CRG90447.1 - 9.2 6.1 6.7 25 4.8 0.2 2.4 2 0 0 2 2 2 0 Dimerisation domain of Male-specific-Lethal 1 TPR_1 PF00515.28 CRG90448.1 - 1.9e-43 144.5 20.5 3.1e-05 23.6 0.2 8.7 9 0 0 9 9 8 8 Tetratricopeptide repeat STI1 PF17830.1 CRG90448.1 - 3.4e-36 123.0 8.4 4.7e-19 68.1 0.4 2.7 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 CRG90448.1 - 1.3e-34 115.5 25.0 4.6e-05 23.2 0.5 9.8 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 CRG90448.1 - 1.6e-17 62.2 25.2 0.00021 21.2 0.1 8.6 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 CRG90448.1 - 1.5e-16 59.8 23.0 6.4e-06 25.8 1.2 8.9 5 3 4 9 9 9 3 TPR repeat TPR_12 PF13424.6 CRG90448.1 - 1.1e-15 57.7 20.2 2.7e-07 30.8 0.3 6.4 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 CRG90448.1 - 2e-14 53.9 23.5 0.00096 19.8 0.0 6.6 4 1 1 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 CRG90448.1 - 5.5e-14 52.4 22.9 0.0046 17.5 0.1 7.2 5 2 1 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 CRG90448.1 - 6.1e-12 45.3 19.7 0.17 12.8 0.0 9.3 5 3 5 10 10 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 CRG90448.1 - 8e-11 41.2 14.5 0.00064 19.6 0.1 7.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG90448.1 - 9.4e-08 31.9 7.4 0.51 10.8 0.1 7.2 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG90448.1 - 9.8e-08 32.0 11.8 0.011 15.8 0.5 6.1 4 2 3 7 7 7 3 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 CRG90448.1 - 0.00046 20.2 6.3 7.5 6.7 0.0 6.3 6 1 1 7 7 7 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 CRG90448.1 - 0.0007 19.8 10.8 0.22 11.8 0.1 4.7 3 1 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CRG90448.1 - 0.00071 20.1 19.8 0.26 12.0 0.0 7.7 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_10 PF13374.6 CRG90448.1 - 0.0024 17.7 16.9 0.068 13.1 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat MIT PF04212.18 CRG90448.1 - 0.036 14.1 20.9 3.7 7.7 0.2 6.5 6 1 0 6 6 6 0 MIT (microtubule interacting and transport) domain Inhibitor_I9 PF05922.16 CRG90448.1 - 0.086 13.5 0.1 0.35 11.6 0.1 2.1 1 0 0 1 1 1 0 Peptidase inhibitor I9 PspA_IM30 PF04012.12 CRG90448.1 - 2.5 7.6 28.1 0.065 12.8 0.5 3.7 4 1 0 4 4 3 0 PspA/IM30 family SHNi-TPR PF10516.9 CRG90448.1 - 7.7 6.1 10.1 36 3.9 0.2 5.0 5 0 0 5 5 5 0 SHNi-TPR DUF627 PF04781.12 CRG90448.1 - 7.8 6.6 7.2 33 4.6 0.6 3.7 4 2 1 5 5 4 0 Protein of unknown function (DUF627) RNA_pol_Rpc34 PF05158.12 CRG90449.1 - 4.8e-96 322.1 0.0 5.3e-96 321.9 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit TrmB PF01978.19 CRG90449.1 - 0.00059 19.7 0.0 0.0011 18.8 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.11 CRG90449.1 - 0.053 14.2 0.0 0.1 13.3 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal MarR PF01047.22 CRG90449.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 MarR family ING PF12998.7 CRG90450.1 - 4e-24 85.1 4.2 7e-24 84.3 4.2 1.4 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding TFIIA PF03153.13 CRG90450.1 - 7.7e-07 29.5 4.1 1.3e-06 28.7 4.1 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PHD PF00628.29 CRG90450.1 - 5.1e-05 23.1 9.4 9.9e-05 22.2 9.4 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 CRG90450.1 - 0.044 14.0 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 PHD-like zinc-binding domain SoxZ PF08770.11 CRG90450.1 - 0.075 12.8 0.1 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Sulphur oxidation protein SoxZ TFIIE-A_C PF11521.8 CRG90450.1 - 0.28 11.5 4.6 0.33 11.3 2.1 2.2 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha NAPRTase PF04095.16 CRG90451.1 - 2.8e-52 177.7 0.0 1.6e-26 93.4 0.1 2.1 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 CRG90451.1 - 3e-34 118.1 0.1 4.8e-34 117.4 0.1 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Cytidylate_kin2 PF13189.6 CRG90451.1 - 0.092 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase-like family Fungal_trans PF04082.18 CRG90452.1 - 1.1e-23 83.6 0.2 1.7e-23 83.0 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Syntaxin PF00804.25 CRG90453.1 - 9.5e-13 48.3 14.1 9.5e-13 48.3 14.1 1.5 2 0 0 2 2 1 1 Syntaxin SNARE PF05739.19 CRG90453.1 - 3.7e-12 46.0 3.0 3.7e-12 46.0 3.0 2.4 2 0 0 2 2 2 1 SNARE domain LMBR1 PF04791.16 CRG90453.1 - 0.002 17.1 4.7 0.0033 16.4 4.7 1.3 1 0 0 1 1 1 1 LMBR1-like membrane protein TMEM156 PF15106.6 CRG90453.1 - 0.0075 15.7 1.7 0.013 14.9 1.7 1.4 1 0 0 1 1 1 1 TMEM156 protein family Prominin PF05478.11 CRG90453.1 - 0.0096 13.9 9.9 0.011 13.7 8.7 1.5 1 1 0 1 1 1 1 Prominin T7SS_ESX_EspC PF10824.8 CRG90453.1 - 0.05 14.1 7.1 3.8 8.1 0.6 3.8 2 1 2 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm VitD-bind_III PF09164.10 CRG90453.1 - 0.054 13.5 0.1 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 Vitamin D binding protein, domain III HisKA_3 PF07730.13 CRG90453.1 - 0.063 13.8 0.1 0.063 13.8 0.1 3.8 4 1 1 5 5 4 0 Histidine kinase BAR_3 PF16746.5 CRG90453.1 - 0.1 12.3 6.8 0.067 12.9 1.0 2.6 2 1 1 3 3 3 0 BAR domain of APPL family Syntaxin-6_N PF09177.11 CRG90453.1 - 0.11 13.1 10.0 0.19 12.3 0.9 3.3 2 1 1 3 3 3 0 Syntaxin 6, N-terminal ODV-E18 PF10717.9 CRG90453.1 - 0.16 11.9 1.0 0.34 10.8 1.0 1.6 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Syntaxin_2 PF14523.6 CRG90453.1 - 0.19 12.1 18.6 0.11 12.9 10.1 2.9 2 2 1 3 3 3 0 Syntaxin-like protein UL42 PF17638.2 CRG90453.1 - 0.21 11.5 0.8 0.36 10.8 0.8 1.4 1 0 0 1 1 1 0 HCMV UL42 DASH_Dad1 PF08649.10 CRG90453.1 - 0.27 11.5 2.4 2.6 8.3 0.1 3.1 2 1 0 2 2 2 0 DASH complex subunit Dad1 DUF2207 PF09972.9 CRG90453.1 - 1.6 7.4 6.9 0.91 8.2 0.3 2.1 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Fib_alpha PF08702.10 CRG90453.1 - 1.8 8.7 15.5 0.4 10.9 4.0 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family GP41 PF00517.17 CRG90453.1 - 2.5 8.0 11.9 0.098 12.6 2.4 2.7 2 1 0 3 3 3 0 Retroviral envelope protein Muted PF14942.6 CRG90453.1 - 2.7 8.3 13.3 5.8 7.3 5.7 2.6 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein NPV_P10 PF05531.12 CRG90453.1 - 7 7.2 10.5 2.6 8.6 0.4 3.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein BolA PF01722.18 CRG90454.1 - 1.5e-27 95.6 3.0 2.1e-27 95.2 3.0 1.2 1 0 0 1 1 1 1 BolA-like protein AMP-binding PF00501.28 CRG90455.1 - 8.8e-66 222.2 0.0 1.2e-65 221.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG90455.1 - 1.1e-12 48.7 0.1 2.5e-12 47.6 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 CRG90457.1 - 4.6e-75 252.8 0.0 5.4e-75 252.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 CRG90457.1 - 3.4e-19 68.5 0.1 8.5e-19 67.2 0.1 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 CRG90457.1 - 4e-14 53.3 0.0 2e-13 51.1 0.0 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Ras PF00071.22 CRG90458.1 - 1.5e-51 174.2 0.4 7e-51 172.0 0.4 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CRG90458.1 - 1.6e-18 67.1 0.0 2.6e-17 63.1 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG90458.1 - 0.0004 19.9 0.0 0.003 17.1 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family FeoB_N PF02421.18 CRG90458.1 - 0.017 14.6 0.1 0.45 10.0 0.0 2.5 2 1 1 3 3 3 0 Ferrous iron transport protein B SRPRB PF09439.10 CRG90458.1 - 0.053 13.0 0.0 0.64 9.4 0.0 2.0 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_25 PF13481.6 CRG90458.1 - 0.12 11.9 0.1 0.33 10.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 CRG90458.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Septin RsgA_GTPase PF03193.16 CRG90458.1 - 0.14 12.0 0.0 9 6.2 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase CinA PF02464.17 CRG90459.1 - 1.2e-37 128.8 0.5 1.4e-37 128.7 0.5 1.0 1 0 0 1 1 1 1 Competence-damaged protein SHMT PF00464.19 CRG90460.1 - 4.3e-198 657.8 0.0 5.1e-198 657.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase AAA_14 PF13173.6 CRG90461.1 - 0.017 15.2 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CRG90461.1 - 0.027 14.8 0.0 0.26 11.5 0.0 2.4 1 1 0 1 1 1 0 AAA domain P63C PF10546.9 CRG90461.1 - 0.04 14.5 0.7 5 7.8 0.0 3.1 2 1 1 3 3 3 0 P63C domain AAA_16 PF13191.6 CRG90461.1 - 0.057 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain NAD_binding_4 PF07993.12 CRG90461.1 - 0.097 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein FAD_binding_4 PF01565.23 CRG90462.1 - 9.3e-24 83.7 1.9 2.4e-23 82.4 1.9 1.7 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG90462.1 - 7.7e-14 51.5 0.0 1.8e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like UCR_UQCRX_QCR9 PF05365.12 CRG90462.1 - 0.11 12.4 2.4 15 5.6 0.1 2.9 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Patatin PF01734.22 CRG90463.1 - 4.7e-15 56.3 0.1 1.8e-14 54.4 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase Mg_trans_NIPA PF05653.14 CRG90464.1 - 5.3e-78 262.1 24.1 7.3e-64 215.7 12.0 2.1 1 1 1 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 CRG90464.1 - 7.5e-05 22.9 5.7 7.5e-05 22.9 5.7 3.3 3 0 0 3 3 3 1 EamA-like transporter family DUF5362 PF17319.2 CRG90464.1 - 0.0041 16.9 1.5 0.01 15.6 0.1 2.4 2 0 0 2 2 2 1 Family of unknown function (DUF5362) rve_3 PF13683.6 CRG90464.1 - 0.097 12.5 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Inhibitor_I53 PF11714.8 CRG90464.1 - 0.19 11.9 0.5 0.58 10.4 0.5 1.8 1 0 0 1 1 1 0 Thrombin inhibitor Madanin BRCT_2 PF16589.5 CRG90465.1 - 2.3e-13 50.4 0.0 9.9e-13 48.3 0.0 2.0 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 CRG90465.1 - 0.0005 20.4 0.0 0.0015 18.9 0.0 1.9 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 CRG90465.1 - 0.00072 19.8 0.0 1.4 9.3 0.0 2.3 2 0 0 2 2 2 2 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 CRG90465.1 - 0.00081 19.3 0.2 0.0027 17.6 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain CAP_N PF01213.19 CRG90465.1 - 0.012 15.1 9.2 0.021 14.3 9.2 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 CRG90465.1 - 0.28 11.2 10.4 0.46 10.5 8.8 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 CRG90465.1 - 0.5 10.4 9.7 0.96 9.5 9.7 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator KilA-N PF04383.13 CRG90466.1 - 7.7e-05 22.5 0.0 0.002 17.9 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain DUF4587 PF15248.6 CRG90466.1 - 0.039 14.8 1.2 0.18 12.6 1.2 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4587) HA2 PF04408.23 CRG90467.1 - 4.5e-16 59.1 0.0 1.9e-15 57.0 0.0 2.2 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 CRG90467.1 - 3.2e-12 46.6 0.0 7.3e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG90467.1 - 3.5e-10 40.2 0.1 3e-09 37.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 CRG90467.1 - 3.7e-06 27.2 0.0 1.1e-05 25.7 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 CRG90467.1 - 2.9e-05 24.4 0.0 0.00013 22.3 0.0 2.2 1 0 0 1 1 1 1 AAA domain PCI PF01399.27 CRG90467.1 - 0.13 12.8 0.3 15 6.1 0.1 3.0 2 0 0 2 2 2 0 PCI domain Occludin_ELL PF07303.13 CRG90467.1 - 0.14 12.9 3.9 2.7 8.8 0.6 3.2 2 0 0 2 2 2 0 Occludin homology domain Gcn1_N PF12074.8 CRG90468.1 - 6.2e-114 381.0 5.8 6.2e-114 381.0 5.8 3.8 3 0 0 3 3 3 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Ribosomal_L19e PF01280.20 CRG90468.1 - 2.2e-59 199.7 8.3 2.2e-59 199.7 8.3 2.2 2 0 0 2 2 2 1 Ribosomal protein L19e HEAT PF02985.22 CRG90468.1 - 6.1e-29 97.6 40.2 0.15 12.4 0.1 22.4 26 0 0 26 26 22 7 HEAT repeat HEAT_2 PF13646.6 CRG90468.1 - 1.7e-25 89.2 48.9 5.2e-05 23.6 0.0 14.7 11 4 4 17 17 15 8 HEAT repeats HEAT_EZ PF13513.6 CRG90468.1 - 8.9e-23 80.4 53.3 1.9e-06 28.3 0.1 20.2 22 2 4 26 26 22 5 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CRG90468.1 - 1.4e-12 48.0 0.1 2.3 8.9 0.2 8.8 8 3 4 12 12 8 4 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 CRG90468.1 - 6.3e-11 42.6 10.5 0.075 13.1 0.6 8.6 7 1 0 8 8 8 2 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 CRG90468.1 - 7.9e-07 28.9 1.9 1.9 8.4 0.0 7.7 9 1 0 9 9 9 1 UME (NUC010) domain ParcG PF10274.9 CRG90468.1 - 1e-06 29.0 5.9 0.34 11.0 0.0 6.8 6 1 1 7 7 6 2 Parkin co-regulated protein DUF937 PF06078.11 CRG90468.1 - 0.00086 19.9 4.2 9 6.9 0.0 6.1 5 2 0 5 5 5 1 Bacterial protein of unknown function (DUF937) TIP120 PF08623.10 CRG90468.1 - 0.0026 17.6 8.3 0.013 15.2 0.0 5.8 7 1 1 8 8 8 1 TATA-binding protein interacting (TIP20) DUF5059 PF16502.5 CRG90468.1 - 0.013 14.3 0.2 0.026 13.3 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5059) FANCI_S2 PF14676.6 CRG90468.1 - 0.092 13.1 1.4 4.1 7.7 0.1 3.9 3 0 0 3 3 3 0 FANCI solenoid 2 ADSL_C PF10397.9 CRG90468.1 - 0.12 12.9 1.1 48 4.6 0.0 4.5 3 0 0 3 3 2 0 Adenylosuccinate lyase C-terminus RasGEF_N_2 PF14663.6 CRG90468.1 - 0.16 12.4 0.8 10 6.6 0.0 4.3 4 0 0 4 4 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTP1_C1 PF10363.9 CRG90468.1 - 0.28 11.4 6.8 43 4.3 0.0 6.1 6 0 0 6 6 5 0 Required for nuclear transport of RNA pol II C-terminus 1 TRAP-gamma PF07074.12 CRG90468.1 - 0.79 9.3 4.5 1.6 8.3 4.5 1.5 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) Ribonuc_L-PSP PF01042.21 CRG90469.1 - 1.1e-07 31.9 0.4 9.4e-07 28.9 0.4 2.3 1 1 0 1 1 1 1 Endoribonuclease L-PSP Herpes_gE PF02480.16 CRG90469.1 - 0.013 14.3 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E RIFIN PF02009.16 CRG90469.1 - 0.024 14.6 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Rifin BatA PF07584.11 CRG90469.1 - 0.035 14.5 0.0 0.069 13.5 0.0 1.4 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal DUF4381 PF14316.6 CRG90469.1 - 0.038 14.2 0.0 0.069 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Alpha_GJ PF03229.13 CRG90469.1 - 0.068 13.7 3.5 0.091 13.3 2.5 1.7 1 1 0 1 1 1 0 Alphavirus glycoprotein J FAD_binding_4 PF01565.23 CRG90471.1 - 1.6e-13 50.6 0.5 3.3e-13 49.6 0.3 1.6 2 0 0 2 2 2 1 FAD binding domain ALO PF04030.14 CRG90471.1 - 0.0012 18.7 4.0 0.0018 18.2 0.3 2.2 2 0 0 2 2 2 1 D-arabinono-1,4-lactone oxidase Glyco_hydro_10 PF00331.20 CRG90471.1 - 0.0021 17.3 0.1 0.004 16.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 GMC_oxred_N PF00732.19 CRG90472.1 - 5.8e-71 239.3 0.0 7.4e-71 238.9 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG90472.1 - 9.3e-21 74.9 0.0 1.5e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CRG90472.1 - 0.00024 21.3 0.3 0.0019 18.4 0.1 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG90472.1 - 0.00056 19.1 0.0 0.0027 16.9 0.0 2.1 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 CRG90472.1 - 0.0012 18.5 0.1 0.0032 17.1 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG90472.1 - 0.0028 16.9 0.0 0.0051 16.1 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 CRG90472.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein adh_short PF00106.25 CRG90473.1 - 3.8e-34 117.9 0.1 5.7e-34 117.3 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90473.1 - 3.4e-22 79.1 0.1 5.8e-22 78.4 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Zn_clus PF00172.18 CRG90473.1 - 1.5e-09 37.9 11.9 3e-09 36.9 11.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KR PF08659.10 CRG90473.1 - 6.8e-06 26.1 0.1 3.6e-05 23.8 0.1 2.0 1 1 0 1 1 1 1 KR domain Trp_oprn_chp PF09534.10 CRG90474.1 - 0.49 10.2 13.7 0.072 12.9 1.4 3.9 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CorA PF01544.18 CRG90475.1 - 7.1e-38 130.6 0.9 6e-37 127.5 0.9 2.1 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein REV PF00424.18 CRG90475.1 - 0.89 9.6 6.3 13 5.9 0.4 3.0 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Vac7 PF12751.7 CRG90476.1 - 8.9e-146 486.2 0.5 8.9e-146 486.2 0.5 2.5 2 1 1 3 3 3 1 Vacuolar segregation subunit 7 DUF4089 PF13318.6 CRG90476.1 - 0.16 12.5 0.0 0.32 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4089) DUF3824 PF12868.7 CRG90477.1 - 2.3e-31 109.5 39.2 2.3e-31 109.5 39.2 9.1 2 1 7 9 9 9 2 Domain of unknwon function (DUF3824) DUF533 PF04391.12 CRG90477.1 - 0.27 10.8 7.3 40 3.7 7.3 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF533) Ribosomal_L44 PF00935.19 CRG90478.1 - 1e-35 122.0 12.6 2.7e-35 120.7 12.6 1.8 1 0 0 1 1 1 1 Ribosomal protein L44 LigT_PEase PF02834.16 CRG90478.1 - 0.0007 19.7 0.0 0.071 13.3 0.0 2.7 2 1 0 2 2 2 1 LigT like Phosphoesterase 2H-phosphodiest PF08975.10 CRG90478.1 - 0.091 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) ubiquitin PF00240.23 CRG90479.1 - 2.5e-19 68.8 0.0 2.9e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 CRG90479.1 - 3e-10 39.8 0.0 3.5e-10 39.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 CRG90479.1 - 0.016 15.1 0.0 0.019 14.9 0.0 1.1 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 CRG90479.1 - 0.021 15.3 0.0 0.071 13.6 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain FAD_binding_3 PF01494.19 CRG90480.1 - 2.7e-76 257.1 0.0 3.9e-76 256.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Elongin_A PF06881.11 CRG90480.1 - 1.1e-29 103.0 1.3 1.8e-29 102.3 0.3 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Pyr_redox_2 PF07992.14 CRG90480.1 - 0.02 14.1 0.0 0.057 12.6 0.0 1.8 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG90480.1 - 0.023 14.3 0.1 2.5 7.6 0.1 2.4 2 0 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG90480.1 - 0.095 11.8 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 CRG90480.1 - 0.25 11.6 4.3 0.077 13.2 0.7 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DBD_Tnp_Mut PF03108.15 CRG90481.1 - 1.2e-09 38.0 0.2 2.2e-09 37.2 0.2 1.4 1 0 0 1 1 1 1 MuDR family transposase Fungal_trans PF04082.18 CRG90481.1 - 3.7e-07 29.5 0.9 1.5e-06 27.4 0.9 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90481.1 - 0.052 13.7 0.6 0.11 12.7 0.6 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain THOC7 PF05615.13 CRG90482.1 - 6.1e-45 152.7 9.5 6.1e-45 152.7 9.5 2.3 1 1 1 2 2 2 1 Tho complex subunit 7 DUF4600 PF15372.6 CRG90482.1 - 0.064 13.7 10.7 0.15 12.5 10.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) FapA PF03961.13 CRG90482.1 - 4.2 5.9 9.3 7.3 5.1 8.7 1.7 1 1 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 CRG90482.1 - 9 5.4 5.9 14 4.8 5.9 1.5 1 0 0 1 1 1 0 TMPIT-like protein TBCA PF02970.16 CRG90483.1 - 1.6e-24 86.1 6.6 2.1e-24 85.6 6.5 1.3 1 1 0 1 1 1 1 Tubulin binding cofactor A T3SSipB PF16535.5 CRG90483.1 - 0.00077 20.0 5.6 0.0056 17.2 5.6 1.9 1 1 0 1 1 1 1 Type III cell invasion protein SipB APC_N_CC PF16689.5 CRG90483.1 - 0.013 15.5 3.8 0.017 15.2 0.2 2.6 3 0 0 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain Dimer_Tnp_Tn5 PF02281.16 CRG90483.1 - 0.017 14.8 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Transposase Tn5 dimerisation domain FIVAR PF07554.13 CRG90483.1 - 0.045 14.5 1.0 0.12 13.1 1.0 1.8 1 1 0 1 1 1 0 FIVAR domain DUF4407 PF14362.6 CRG90483.1 - 0.16 11.3 5.1 0.18 11.2 5.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 CRG90483.1 - 0.16 12.2 1.2 2.1 8.6 0.4 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PspA_IM30 PF04012.12 CRG90483.1 - 0.16 11.5 12.4 0.61 9.6 2.4 2.1 1 1 1 2 2 2 0 PspA/IM30 family FlgN PF05130.12 CRG90483.1 - 0.21 12.1 7.4 0.46 11.0 7.4 1.6 1 1 0 1 1 1 0 FlgN protein Matrilin_ccoil PF10393.9 CRG90483.1 - 0.37 10.7 4.1 1.8 8.5 0.3 2.8 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin CENP-Q PF13094.6 CRG90483.1 - 1.3 9.2 11.7 9.8 6.4 11.7 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Sugar_tr PF00083.24 CRG90485.1 - 1.9e-79 267.7 29.7 2.8e-79 267.1 29.7 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG90485.1 - 9.2e-21 74.1 37.7 2.9e-20 72.5 33.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Band_7 PF01145.25 CRG90485.1 - 2.6e-13 50.4 0.1 2.6e-13 50.4 0.1 2.3 2 1 0 2 2 2 1 SPFH domain / Band 7 family OATP PF03137.20 CRG90485.1 - 0.0017 16.7 8.9 0.0056 15.0 7.6 2.1 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Atg14 PF10186.9 CRG90485.1 - 0.32 10.1 10.0 0.39 9.7 8.8 1.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAD_binding_3 PF01494.19 CRG90486.1 - 2.9e-12 46.5 0.9 4.5e-08 32.7 0.0 2.9 2 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CRG90486.1 - 3.3e-10 39.7 0.7 4.8e-05 22.7 0.2 2.3 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG90486.1 - 2.4e-06 26.9 0.0 5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG90486.1 - 6.2e-06 26.4 0.1 2.6e-05 24.4 0.0 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG90486.1 - 1.1e-05 24.3 0.1 0.0011 17.7 0.0 2.1 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 CRG90486.1 - 0.00025 20.5 0.0 0.00033 20.1 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG90486.1 - 0.00043 20.8 0.1 0.019 15.5 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG90486.1 - 0.00056 19.1 0.0 0.001 18.2 0.0 1.4 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CRG90486.1 - 0.0013 18.1 0.1 0.17 11.1 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90486.1 - 0.0027 17.7 0.1 1.3 8.9 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 CRG90486.1 - 0.0072 15.9 0.0 0.017 14.8 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG90486.1 - 0.012 14.9 0.0 0.028 13.7 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Trp_halogenase PF04820.14 CRG90486.1 - 0.013 14.4 0.0 1.7 7.4 0.0 2.4 2 0 0 2 2 2 0 Tryptophan halogenase Lycopene_cycl PF05834.12 CRG90486.1 - 0.015 14.3 0.0 1 8.3 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 CRG90486.1 - 0.028 13.6 0.4 0.1 11.9 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Amino_oxidase PF01593.24 CRG90486.1 - 0.099 11.9 0.0 13 4.9 0.0 2.2 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase adh_short PF00106.25 CRG90487.1 - 9.6e-26 90.4 0.2 7.4e-20 71.2 0.3 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90487.1 - 2.3e-16 60.0 0.5 3.3e-13 49.7 0.2 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90487.1 - 1.6e-07 31.4 0.5 2.8e-07 30.6 0.5 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG90487.1 - 0.015 14.4 0.0 0.029 13.5 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 CRG90487.1 - 0.061 13.6 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain MFS_1 PF07690.16 CRG90488.1 - 4.2e-39 134.5 39.9 1.8e-35 122.5 40.8 4.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG90488.1 - 3.3e-11 42.3 14.5 5.1e-11 41.7 14.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG90488.1 - 0.00077 18.4 1.3 0.00077 18.4 1.3 3.3 2 1 1 3 3 3 2 Sugar (and other) transporter Fungal_trans PF04082.18 CRG90489.1 - 1.5e-27 96.3 0.1 2.8e-27 95.4 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90489.1 - 0.0037 17.3 4.0 0.0078 16.3 4.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rtf2 PF04641.12 CRG90489.1 - 0.12 11.8 0.5 0.18 11.2 0.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger SBD_N PF07005.11 CRG90490.1 - 7.2e-60 202.5 0.1 9.7e-60 202.1 0.1 1.2 1 0 0 1 1 1 1 Sugar-binding N-terminal domain NBD_C PF17042.5 CRG90490.1 - 2e-38 132.6 0.0 3.7e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 Nucleotide-binding C-terminal domain DnaJ PF00226.31 CRG90491.1 - 7.7e-26 90.0 2.1 1.3e-25 89.3 2.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 CRG90491.1 - 3.9e-25 88.7 0.0 5.7e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 CRG90491.1 - 6.6e-15 55.2 17.4 1.1e-14 54.5 17.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 CRG90491.1 - 1.7e-05 24.7 10.0 0.02 14.8 2.3 2.4 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein Lar_restr_allev PF14354.6 CRG90491.1 - 0.0013 19.1 8.8 0.23 11.9 0.1 2.9 2 1 1 3 3 3 2 Restriction alleviation protein Lar HypA PF01155.19 CRG90491.1 - 0.021 14.8 7.1 1.4 9.0 0.4 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GRP PF07172.11 CRG90491.1 - 0.68 10.7 11.6 1.9 9.3 11.6 1.8 1 0 0 1 1 1 0 Glycine rich protein family TackOD1 PF18551.1 CRG90491.1 - 1.2 8.8 8.5 3 7.5 1.0 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 CRG90491.1 - 6.8 6.8 10.9 58 3.8 10.9 2.1 1 1 0 1 1 1 0 Double zinc ribbon DUF4449 PF14613.6 CRG90492.1 - 2.7e-07 30.9 1.7 3.4e-06 27.3 1.7 2.9 1 1 0 1 1 1 1 Protein of unknown function (DUF4449) AbiH PF14253.6 CRG90492.1 - 0.0089 15.9 0.7 0.02 14.8 0.7 1.6 1 0 0 1 1 1 1 Bacteriophage abortive infection AbiH Malic_M PF03949.15 CRG90493.1 - 6.8e-90 300.8 0.0 8.7e-90 300.5 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CRG90493.1 - 1.6e-63 213.8 0.0 2.8e-63 213.0 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain AAA_12 PF13087.6 CRG90494.1 - 4e-08 33.1 0.0 7e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 CRG90494.1 - 0.097 12.5 0.0 0.21 11.4 0.0 1.6 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain HMG_CoA_synt_C PF08540.10 CRG90495.1 - 2.9e-97 325.7 0.2 3.5e-97 325.4 0.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 CRG90495.1 - 2.2e-87 291.4 0.2 3.9e-87 290.6 0.1 1.5 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal adh_short PF00106.25 CRG90497.1 - 1.3e-18 67.1 0.0 2.2e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90497.1 - 3.4e-11 43.1 0.0 5.5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase S4 PF01479.25 CRG90497.1 - 5.9e-08 32.3 0.1 3.3e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 CRG90497.1 - 1.1e-07 32.7 0.4 2.4e-07 31.6 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain KR PF08659.10 CRG90497.1 - 0.00018 21.4 0.1 0.00059 19.8 0.0 1.8 2 0 0 2 2 2 1 KR domain Speriolin_C PF15059.6 CRG90497.1 - 0.088 12.9 0.1 0.27 11.3 0.0 1.8 2 0 0 2 2 2 0 Speriolin C-terminus MFS_1 PF07690.16 CRG90498.1 - 2e-36 125.6 27.6 3.1e-36 125.0 27.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG90498.1 - 0.023 13.6 13.4 0.048 12.5 12.5 1.8 1 1 1 2 2 2 0 MFS_1 like family OMPdecase PF00215.24 CRG90499.1 - 1.1e-78 263.9 0.0 1.3e-78 263.7 0.0 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family MBOAT PF03062.19 CRG90500.1 - 1.2e-24 87.4 14.0 2.1e-24 86.5 14.0 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MAPEG PF01124.18 CRG90500.1 - 8.6e-22 77.4 1.7 8.6e-22 77.4 1.7 2.8 3 0 0 3 3 3 1 MAPEG family MBOAT_2 PF13813.6 CRG90500.1 - 0.024 14.9 3.2 0.08 13.2 3.2 1.9 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family WD40 PF00400.32 CRG90501.1 - 2.6e-31 107.2 34.7 8.6e-07 29.6 3.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90501.1 - 7.7e-18 64.6 0.1 0.00076 19.7 0.0 5.3 2 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 CRG90501.1 - 0.066 11.5 0.0 0.37 9.0 0.0 1.9 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Bacteroid_pep PF14406.6 CRG90501.1 - 0.14 12.6 0.1 0.58 10.6 0.0 2.1 2 0 0 2 2 2 0 Ribosomally synthesized peptide in Bacteroidetes Tmemb_170 PF10190.9 CRG90502.1 - 1.3e-18 67.3 15.5 1.6e-18 67.0 15.5 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 ICMT PF04140.14 CRG90504.1 - 8.6e-27 93.4 0.5 1.6e-26 92.5 0.5 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 CRG90504.1 - 2.4e-11 43.9 2.0 2.4e-11 43.9 2.0 2.2 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 CRG90504.1 - 2.4e-05 24.0 0.4 3.8e-05 23.3 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 CRG90504.1 - 0.0054 16.3 1.0 0.0054 16.3 1.0 2.3 1 1 0 2 2 2 1 NnrU protein DUF3188 PF11384.8 CRG90504.1 - 0.067 12.9 2.0 0.13 12.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3188) DUF3517 PF12030.8 CRG90505.1 - 1.2e-101 340.1 0.0 2.5e-101 339.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3517) UCH PF00443.29 CRG90505.1 - 2.5e-39 135.3 0.3 7.7e-39 133.7 0.3 1.9 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG90505.1 - 3e-22 79.6 0.7 2.2e-21 76.8 0.7 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ADD_ATRX PF17981.1 CRG90505.1 - 0.32 10.9 1.4 0.48 10.3 0.1 1.9 2 0 0 2 2 2 0 Cysteine Rich ADD domain TFIIE_alpha PF02002.17 CRG90506.1 - 3.3e-18 65.5 0.0 3.3e-18 65.5 0.0 1.7 2 0 0 2 2 2 1 TFIIE alpha subunit HTH_Crp_2 PF13545.6 CRG90506.1 - 0.048 13.6 0.2 0.082 12.9 0.2 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Acetyltransf_8 PF13523.6 CRG90506.1 - 0.097 12.4 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Zn-ribbon_8 PF09723.10 CRG90506.1 - 0.15 12.2 0.7 0.48 10.6 0.7 1.9 1 1 0 1 1 1 0 Zinc ribbon domain SWI-SNF_Ssr4 PF08549.10 CRG90506.1 - 2 6.9 18.9 0.21 10.2 14.0 1.6 1 1 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PseudoU_synth_1 PF01416.20 CRG90507.1 - 1e-10 42.0 0.0 6.3e-09 36.3 0.0 2.9 3 0 0 3 3 3 1 tRNA pseudouridine synthase Anillin PF08174.11 CRG90508.1 - 1.1e-09 38.8 0.0 2.9e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 CRG90508.1 - 3e-09 37.3 0.0 1.1e-08 35.5 0.0 2.1 1 0 0 1 1 1 1 PH domain DEAD PF00270.29 CRG90509.1 - 2.7e-33 115.2 0.0 4.4e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG90509.1 - 5e-17 62.2 0.3 1.9e-14 53.9 0.6 3.2 2 1 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG90509.1 - 2.3e-08 34.2 0.0 4.6e-07 30.0 0.0 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 CRG90509.1 - 0.0013 17.5 0.0 0.0022 16.8 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2620 PF10941.8 CRG90509.1 - 0.16 12.1 0.0 0.5 10.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF2620 MFS_1 PF07690.16 CRG90510.1 - 1.7e-40 139.1 55.5 1.3e-33 116.4 46.9 2.9 2 1 0 2 2 2 2 Major Facilitator Superfamily Peptidase_U4 PF03419.13 CRG90510.1 - 0.52 9.6 0.0 0.52 9.6 0.0 3.3 2 1 1 3 3 3 0 Sporulation factor SpoIIGA DUF3262 PF11660.8 CRG90510.1 - 0.56 10.6 10.5 0.46 10.9 1.0 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3262) OATP PF03137.20 CRG90510.1 - 0.64 8.2 22.0 0.012 13.9 3.9 3.4 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family FAD_binding_3 PF01494.19 CRG90511.1 - 4e-23 82.2 0.0 6.4e-23 81.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 CRG90511.1 - 6.7e-05 22.1 0.0 9.7e-05 21.6 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 CRG90511.1 - 0.00022 21.4 0.1 0.00086 19.5 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CRG90511.1 - 0.00044 19.6 0.2 0.00076 18.8 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 CRG90511.1 - 0.00076 18.8 0.3 0.0015 17.9 0.3 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG90511.1 - 0.005 16.5 0.7 0.014 15.0 0.7 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG90511.1 - 0.012 16.2 0.1 0.036 14.6 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG90511.1 - 0.015 14.0 0.1 0.026 13.3 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.7 CRG90511.1 - 0.067 12.5 1.7 0.3 10.4 0.2 2.4 3 0 0 3 3 3 0 FAD dependent oxidoreductase NTF-like PF14540.6 CRG90511.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase-like FAD_binding_2 PF00890.24 CRG90511.1 - 0.12 11.4 0.1 0.24 10.4 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 CRG90511.1 - 0.18 11.0 0.3 0.77 9.0 0.1 2.0 2 0 0 2 2 2 0 Thi4 family Glyco_hydro_64 PF16483.5 CRG90512.1 - 2.1e-136 455.0 4.3 2.5e-136 454.8 4.3 1.1 1 0 0 1 1 1 1 Beta-1,3-glucanase ACPS PF01648.20 CRG90513.1 - 1.8e-13 50.6 0.0 4.3e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily SNO PF01174.19 CRG90514.1 - 9.3e-56 188.7 0.0 9.7e-45 152.7 0.0 2.0 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 CRG90514.1 - 1.7e-10 40.8 0.0 5.3e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 CRG90514.1 - 0.00065 19.5 0.0 0.0079 16.0 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 CRG90514.1 - 0.014 15.2 0.0 0.028 14.2 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family Peptidase_S51 PF03575.17 CRG90514.1 - 0.016 14.8 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 ThiJ_like PF17124.5 CRG90514.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like RRM_1 PF00076.22 CRG90515.1 - 1.1e-15 57.1 0.0 1.8e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup54 PF13874.6 CRG90516.1 - 0.014 15.5 0.5 0.03 14.4 0.5 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF948 PF06103.11 CRG90516.1 - 0.13 12.6 0.1 0.49 10.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF366 PF04017.12 CRG90516.1 - 0.15 11.5 0.0 0.28 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF366) Ribosomal_L14 PF00238.19 CRG90517.1 - 1.1e-47 161.2 1.5 1.2e-47 161.0 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e DUF4777 PF16007.5 CRG90517.1 - 0.064 13.5 0.1 0.23 11.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4777) Phage_antitermQ PF06530.12 CRG90517.1 - 0.068 13.1 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Phage antitermination protein Q RNA_POL_M_15KD PF02150.16 CRG90518.1 - 5.5e-12 45.3 1.4 5.5e-12 45.3 1.4 3.3 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit C1_1 PF00130.22 CRG90518.1 - 0.0055 16.6 6.6 0.56 10.1 0.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) GFA PF04828.14 CRG90518.1 - 0.0078 16.5 6.6 1 9.7 0.1 2.4 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.6 CRG90518.1 - 1.1 9.0 10.1 27 4.6 4.8 3.5 2 1 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 CRG90518.1 - 8.2 6.4 16.0 11 6.0 0.2 3.5 2 2 1 3 3 3 0 Nudix N-terminal Rotamase PF00639.21 CRG90519.1 - 4.7e-22 78.7 0.0 6.7e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 CRG90519.1 - 9e-14 52.0 0.0 1.3e-13 51.5 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 CRG90519.1 - 2.9e-09 36.9 2.5 2.9e-09 36.9 1.1 1.8 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 CRG90519.1 - 0.0015 19.4 0.0 0.0022 18.8 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain DUF2379 PF09543.10 CRG90519.1 - 0.094 12.9 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) Na_Ca_ex PF01699.24 CRG90520.1 - 1.2e-32 113.0 34.8 4.4e-19 68.9 16.9 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein SET PF00856.28 CRG90520.1 - 1.3e-12 48.4 0.0 7.2e-10 39.5 0.0 2.7 2 0 0 2 2 2 2 SET domain SAF PF08666.12 CRG90520.1 - 0.00063 20.3 0.1 2.1 9.0 0.0 2.6 2 0 0 2 2 2 2 SAF domain FAD_binding_4 PF01565.23 CRG90521.1 - 3.6e-16 59.2 0.1 1.3e-15 57.4 0.1 1.9 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG90521.1 - 0.076 13.1 0.0 0.22 11.6 0.0 1.8 1 0 0 1 1 1 0 Berberine and berberine like DUF3328 PF11807.8 CRG90522.1 - 4.7e-37 127.9 1.4 5.7e-37 127.6 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) Methyltransf_23 PF13489.6 CRG90523.1 - 6.3e-17 61.9 0.0 8.2e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90523.1 - 1.7e-13 51.0 0.0 2.6e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90523.1 - 2.1e-10 41.2 0.0 3.1e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG90523.1 - 8.3e-10 39.3 0.0 1.2e-09 38.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90523.1 - 2.1e-07 30.9 0.0 2.7e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG90523.1 - 6.2e-05 22.4 0.0 7.7e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF938 PF06080.12 CRG90523.1 - 0.019 14.7 0.0 0.026 14.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF938) RrnaAD PF00398.20 CRG90523.1 - 0.068 12.2 0.0 0.1 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_8 PF05148.15 CRG90523.1 - 0.095 12.5 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.17 CRG90523.1 - 0.11 11.6 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family TMEM208_SND2 PF05620.11 CRG90524.1 - 1.5e-56 190.8 0.1 1.7e-56 190.6 0.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 TPR_1 PF00515.28 CRG90525.1 - 1.4e-41 138.6 22.0 2.5e-09 36.6 0.2 10.1 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 CRG90525.1 - 1.7e-35 118.3 20.4 2.7e-06 27.1 0.1 10.4 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG90525.1 - 5.2e-34 116.3 18.9 1.2e-25 89.6 0.3 4.4 3 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 CRG90525.1 - 4.7e-25 85.7 16.3 6.1e-05 22.9 0.1 9.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 CRG90525.1 - 1.4e-19 69.4 19.4 0.00038 20.1 0.4 9.1 7 2 3 10 10 9 5 TPR repeat TPR_14 PF13428.6 CRG90525.1 - 3e-18 65.0 10.5 0.0074 17.0 0.0 9.6 6 2 4 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 CRG90525.1 - 2.2e-17 63.4 11.9 0.0017 19.0 0.0 8.3 6 2 2 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 CRG90525.1 - 1.6e-14 54.1 23.6 1.6e-07 31.7 0.1 8.0 6 3 2 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 CRG90525.1 - 1.4e-12 47.1 18.1 0.39 11.2 0.0 9.9 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 CRG90525.1 - 1.6e-11 44.3 19.7 0.24 11.7 0.2 8.1 4 2 5 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 CRG90525.1 - 9e-10 37.9 11.9 0.096 12.8 0.0 7.5 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 CRG90525.1 - 5.5e-07 29.6 3.9 0.17 12.1 0.1 5.0 3 2 2 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 CRG90525.1 - 5e-05 23.7 21.4 3 8.7 0.0 8.8 11 0 0 11 11 9 2 Tetratricopeptide repeat Sel1 PF08238.12 CRG90525.1 - 0.0015 19.1 1.1 15 6.4 0.0 5.3 6 0 0 6 6 4 0 Sel1 repeat TPR_15 PF13429.6 CRG90525.1 - 0.0025 17.1 7.3 1.6 7.8 1.3 4.4 3 1 1 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG90525.1 - 0.0033 17.3 1.5 4.8 7.2 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_21 PF09976.9 CRG90525.1 - 0.027 14.2 6.1 0.43 10.2 1.7 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain ChAPs PF09295.10 CRG90525.1 - 0.066 12.2 1.1 19 4.1 0.0 3.1 1 1 3 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) DUF5113 PF17140.4 CRG90525.1 - 0.81 9.5 4.9 0.37 10.6 1.2 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) DUF2225 PF09986.9 CRG90525.1 - 2.1 8.0 6.3 2.2 7.9 0.1 3.1 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Acyltransferase PF01553.21 CRG90526.1 - 1.9e-32 111.7 0.0 3.3e-32 110.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Flavin_Reduct PF01613.18 CRG90527.1 - 4.8e-15 55.9 0.0 6.4e-15 55.5 0.0 1.1 1 0 0 1 1 1 1 Flavin reductase like domain RINGv PF12906.7 CRG90529.1 - 2.4e-16 59.5 7.4 4.2e-16 58.8 7.4 1.4 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 CRG90529.1 - 0.0025 18.1 7.3 0.0045 17.3 7.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 CRG90529.1 - 0.33 11.0 1.7 0.73 9.9 1.7 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 CRG90529.1 - 2.5 8.0 4.4 5.7 6.9 4.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 CRG90529.1 - 4 7.3 6.4 6.7 6.6 6.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain HeLo PF14479.6 CRG90530.1 - 1.7e-06 28.1 0.5 0.00063 19.6 0.5 2.7 1 1 0 1 1 1 1 Prion-inhibition and propagation Peptidase_S64 PF08192.11 CRG90530.1 - 0.0054 15.3 0.0 0.0054 15.3 0.0 2.5 3 0 0 3 3 3 1 Peptidase family S64 Pkinase_Tyr PF07714.17 CRG90530.1 - 0.11 11.7 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine kinase Glyco_transf_20 PF00982.21 CRG90531.1 - 3.3e-153 510.8 0.0 5.2e-153 510.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Hemerythrin PF01814.23 CRG90531.1 - 3.4e-13 50.4 0.8 7.5e-13 49.2 0.8 1.6 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain Glycos_transf_1 PF00534.20 CRG90531.1 - 0.0042 16.6 0.1 0.56 9.7 0.0 2.5 2 1 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG90531.1 - 0.011 16.1 0.0 0.024 15.1 0.0 1.7 1 1 0 1 1 1 0 Glycosyl transferases group 1 ACC_central PF08326.12 CRG90532.1 - 5.5e-278 924.1 0.0 7.2e-278 923.8 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 CRG90532.1 - 5e-188 625.7 0.0 3.7e-187 622.9 0.0 2.0 2 0 0 2 2 2 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 CRG90532.1 - 2.4e-54 184.1 0.0 4.6e-54 183.1 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 CRG90532.1 - 6.5e-28 97.5 0.1 1.3e-27 96.5 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 CRG90532.1 - 2.8e-22 78.8 0.0 9.9e-20 70.7 0.0 3.0 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 CRG90532.1 - 2e-17 62.8 0.1 4.8e-17 61.6 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CRG90532.1 - 0.00023 20.8 0.1 0.00075 19.1 0.0 1.9 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CRG90532.1 - 0.00077 19.5 0.0 0.0029 17.7 0.0 2.0 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 CRG90532.1 - 0.0013 18.5 0.0 0.0044 16.8 0.0 1.9 1 0 0 1 1 1 1 Biotin-lipoyl like ATP-grasp PF02222.22 CRG90532.1 - 0.014 15.0 0.0 0.031 13.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GxGYxYP_N PF16216.5 CRG90532.1 - 0.046 13.9 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal RnfC_N PF13375.6 CRG90532.1 - 0.097 12.6 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain NUDE_C PF04880.13 CRG90533.1 - 1.3e-50 172.3 9.6 1.3e-50 172.3 9.6 4.3 3 1 1 4 4 2 1 NUDE protein, C-terminal conserved region ZapB PF06005.12 CRG90533.1 - 0.00059 20.2 5.8 0.00059 20.2 5.8 4.8 2 1 3 5 5 5 1 Cell division protein ZapB TPR_MLP1_2 PF07926.12 CRG90533.1 - 0.0059 16.7 36.6 0.47 10.5 10.8 3.5 1 1 2 3 3 3 3 TPR/MLP1/MLP2-like protein Uso1_p115_C PF04871.13 CRG90533.1 - 0.014 15.8 31.2 0.48 10.8 4.3 2.5 1 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Atg14 PF10186.9 CRG90533.1 - 0.047 12.8 29.7 0.0073 15.4 4.9 2.6 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Chibby PF14645.6 CRG90533.1 - 0.053 13.9 11.1 0.2 12.1 6.5 3.0 1 1 2 3 3 3 0 Chibby family CENP-F_leu_zip PF10473.9 CRG90533.1 - 0.23 11.5 34.1 0.87 9.6 22.4 3.3 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 CRG90533.1 - 0.28 10.7 30.5 2.3 7.7 30.5 2.3 1 1 0 1 1 1 0 Intermediate filament protein Fez1 PF06818.15 CRG90533.1 - 0.48 10.8 30.2 2.1 8.7 15.1 3.2 2 1 1 3 3 2 0 Fez1 APG6_N PF17675.1 CRG90533.1 - 0.72 10.4 44.0 2.4 8.7 12.6 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region PSII_Pbs27 PF13326.6 CRG90533.1 - 1.2 9.5 11.7 0.14 12.5 6.8 2.0 2 0 0 2 2 2 0 Photosystem II Pbs27 AAA_13 PF13166.6 CRG90533.1 - 1.3 7.6 22.4 1.9 7.1 22.4 1.1 1 0 0 1 1 1 0 AAA domain DUF1043 PF06295.12 CRG90533.1 - 1.8 8.6 16.1 0.44 10.5 11.3 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) Tropomyosin_1 PF12718.7 CRG90533.1 - 1.9 8.7 34.8 28 4.8 4.1 3.9 2 1 1 3 3 3 0 Tropomyosin like ERM PF00769.19 CRG90533.1 - 2.3 7.9 34.8 0.33 10.7 18.2 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF3584 PF12128.8 CRG90533.1 - 3.2 5.1 26.5 4.7 4.6 26.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.6 CRG90533.1 - 4.3 6.6 32.6 4.6 6.5 14.9 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 CRG90533.1 - 4.6 7.3 31.5 4.4 7.4 3.3 3.9 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Phage_GP20 PF06810.11 CRG90533.1 - 5.6 6.8 24.0 4.7 7.0 8.9 3.7 1 1 2 3 3 3 0 Phage minor structural protein GP20 Taxilin PF09728.9 CRG90533.1 - 9.3 5.3 30.2 3.8 6.6 20.6 2.6 1 1 1 2 2 2 0 Myosin-like coiled-coil protein dUTPase PF00692.19 CRG90534.1 - 1.1e-12 47.8 0.0 1.7e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 dUTPase DCD PF06559.11 CRG90534.1 - 0.00073 18.4 0.0 0.0015 17.4 0.0 1.5 1 1 0 1 1 1 1 2'-deoxycytidine 5'-triphosphate deaminase (DCD) Fungal_trans PF04082.18 CRG90535.1 - 1.1e-17 64.0 0.5 1.5e-17 63.5 0.5 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 CRG90536.1 - 7.8e-55 186.0 0.6 1e-54 185.5 0.6 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG90536.1 - 4.3e-16 59.3 0.1 6.4e-16 58.8 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG90536.1 - 0.0012 17.9 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 CRG90536.1 - 0.15 12.3 0.1 0.36 11.1 0.1 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GST_C PF00043.25 CRG90537.1 - 3.6e-13 49.6 0.3 6.6e-13 48.7 0.1 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CRG90537.1 - 5.8e-13 49.0 0.0 1.6e-12 47.6 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CRG90537.1 - 8e-12 45.4 0.0 1.4e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG90537.1 - 2.4e-11 43.7 0.0 3.7e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG90537.1 - 6.8e-11 42.3 0.0 2.1e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG90537.1 - 0.0059 16.6 0.1 0.015 15.3 0.1 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG90537.1 - 0.053 14.3 0.1 0.22 12.3 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase N-terminal domain DUF1295 PF06966.12 CRG90538.1 - 3.3e-06 26.8 1.6 1.1e-05 25.1 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) Acatn PF13000.7 CRG90538.1 - 0.00029 19.5 0.8 0.00037 19.2 0.8 1.1 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 Isochorismatase PF00857.20 CRG90539.1 - 4.2e-44 150.8 0.0 7.7e-44 149.9 0.0 1.4 1 0 0 1 1 1 1 Isochorismatase family FAR1 PF03101.15 CRG90539.1 - 4e-05 24.2 0.0 7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.11 CRG90539.1 - 0.076 13.4 0.0 0.15 12.5 0.0 1.4 1 0 0 1 1 1 0 Transcription factor AFT Sedlin_N PF04628.13 CRG90540.1 - 9.3e-41 139.0 0.0 1.1e-40 138.8 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 CRG90540.1 - 0.00036 20.5 0.0 0.0062 16.5 0.0 2.0 2 0 0 2 2 2 1 Sybindin-like family DUF4012 PF13196.6 CRG90540.1 - 0.02 15.3 0.1 0.042 14.3 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4012) Abhydrolase_3 PF07859.13 CRG90541.1 - 1.6e-13 51.1 0.0 2.2e-13 50.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG90541.1 - 9e-07 28.6 0.0 0.002 17.6 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 CRG90541.1 - 0.00013 20.7 0.0 0.06 12.0 0.0 2.1 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) COesterase PF00135.28 CRG90541.1 - 0.0003 19.8 0.0 0.00082 18.4 0.0 1.6 2 0 0 2 2 2 1 Carboxylesterase family Hydrolase_4 PF12146.8 CRG90541.1 - 0.00052 19.4 0.0 0.0014 18.0 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 CRG90541.1 - 0.0015 18.4 0.0 1 9.1 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Chlorophyllase2 PF12740.7 CRG90541.1 - 0.0063 15.5 0.0 0.0097 14.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 CRG90541.1 - 0.0088 15.1 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Esterase_phd PF10503.9 CRG90541.1 - 0.045 13.2 0.0 0.13 11.7 0.0 1.8 2 0 0 2 2 2 0 Esterase PHB depolymerase DUF2974 PF11187.8 CRG90541.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF2040 PF09745.9 CRG90542.1 - 4.6e-38 130.0 21.3 4.6e-38 130.0 21.3 4.6 4 1 1 5 5 5 1 Coiled-coil domain-containing protein 55 (DUF2040) Zip PF02535.22 CRG90543.1 - 8e-22 77.9 9.4 1.9e-20 73.4 9.4 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter Endonuclease_NS PF01223.23 CRG90544.1 - 6.3e-63 212.6 0.0 7.7e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease zf-RING_UBOX PF13445.6 CRG90545.1 - 2.2e-07 30.8 9.3 1.2e-05 25.3 3.2 3.0 2 1 0 2 2 2 2 RING-type zinc-finger zf-NOSIP PF15906.5 CRG90545.1 - 8.8e-06 25.8 0.0 2.1e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_2 PF13923.6 CRG90545.1 - 4.4e-05 23.2 10.3 0.00028 20.6 3.2 2.9 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG90545.1 - 0.00013 22.2 12.1 0.0089 16.3 5.9 2.8 2 1 0 2 2 2 2 Ring finger domain zf-RING_5 PF14634.6 CRG90545.1 - 0.00033 20.6 5.4 0.00033 20.6 5.4 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CRG90545.1 - 0.0017 18.2 13.0 0.0084 16.0 3.1 3.3 3 1 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG90545.1 - 0.0018 18.1 2.7 0.0018 18.1 2.7 3.0 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 CRG90545.1 - 0.0061 16.7 9.6 0.049 13.8 4.5 3.1 2 1 1 3 3 3 1 FYVE zinc finger zf-C3HC4_5 PF17121.5 CRG90545.1 - 0.052 13.4 1.1 0.14 12.0 1.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.9 CRG90545.1 - 1.5 9.3 6.4 1.5 9.3 1.1 2.8 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF4834 PF16118.5 CRG90545.1 - 5.1 8.1 9.4 5.9 7.9 7.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) zf-C3HC4_4 PF15227.6 CRG90545.1 - 6.1 7.1 13.7 2.2 8.5 5.9 3.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING Sec7 PF01369.20 CRG90546.1 - 1.5e-33 116.0 1.0 2.3e-33 115.4 1.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 CRG90546.1 - 4.3e-07 30.3 0.1 9.3e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 CRG90546.1 - 2.2e-05 24.9 0.1 6.9e-05 23.3 0.1 1.9 1 0 0 1 1 1 1 PH domain KELK PF15796.5 CRG90546.1 - 2.1 8.9 5.3 0.85 10.1 1.0 2.5 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Peptidase_M14 PF00246.24 CRG90547.1 - 1.3e-78 264.7 0.0 1.7e-78 264.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Propep_M14 PF02244.16 CRG90547.1 - 0.024 15.0 0.2 0.043 14.2 0.2 1.4 1 0 0 1 1 1 0 Carboxypeptidase activation peptide BTB PF00651.31 CRG90548.1 - 1.2e-11 44.8 0.0 9.5e-11 41.9 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain DUF4763 PF15960.5 CRG90548.1 - 0.041 13.2 1.1 0.082 12.2 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) bZIP_1 PF00170.21 CRG90548.1 - 1.2 9.3 4.7 6.6 6.9 4.7 2.3 1 1 0 1 1 1 0 bZIP transcription factor CorA PF01544.18 CRG90551.1 - 8.8e-10 38.4 1.0 1.5e-09 37.6 1.0 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MFS_1 PF07690.16 CRG90551.1 - 0.044 12.7 0.2 0.067 12.1 0.2 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily NicO PF03824.16 CRG90552.1 - 2.4e-60 204.3 13.4 4.4e-57 193.6 5.4 2.1 2 0 0 2 2 2 2 High-affinity nickel-transport protein DctQ PF04290.12 CRG90552.1 - 0.8 9.6 10.3 0.025 14.5 2.2 2.6 2 1 1 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component PhoLip_ATPase_C PF16212.5 CRG90553.1 - 1.3e-81 274.0 20.1 1.3e-81 274.0 20.1 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CRG90553.1 - 3e-25 87.7 8.5 7.1e-25 86.5 8.5 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal DNA_pol_B_thumb PF14791.6 CRG90553.1 - 5.4e-20 71.3 0.2 2.3e-19 69.3 0.2 2.2 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 CRG90553.1 - 1.1e-19 70.0 0.5 3.6e-19 68.3 0.5 2.0 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 CRG90553.1 - 2.2e-16 60.1 0.1 8.9e-16 58.1 0.0 2.2 2 0 0 2 2 2 1 DNA polymerase beta palm Cation_ATPase PF13246.6 CRG90553.1 - 2.4e-11 43.6 0.0 9.8e-11 41.6 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG90553.1 - 2.9e-11 44.1 1.0 5.9e-07 30.0 0.4 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HHH_8 PF14716.6 CRG90553.1 - 1.4e-09 38.2 0.0 1.6e-08 34.8 0.0 2.8 3 0 0 3 3 2 1 Helix-hairpin-helix domain E1-E2_ATPase PF00122.20 CRG90553.1 - 6.8e-05 22.5 0.0 0.00014 21.4 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CRG90553.1 - 0.0048 16.7 0.3 0.034 13.9 0.1 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HHH_5 PF14520.6 CRG90553.1 - 0.16 12.6 0.0 0.86 10.3 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain RNase_PH PF01138.21 CRG90554.1 - 5.7e-17 62.5 0.0 9.9e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 CRG90554.1 - 2.6e-06 27.4 0.0 4.9e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 CcdA PF07362.12 CRG90554.1 - 0.13 12.8 1.6 0.31 11.5 1.6 1.6 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA Cwf_Cwc_15 PF04889.12 CRG90555.1 - 1.3e-81 274.0 21.4 1.5e-81 273.7 21.4 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein PA26 PF04636.13 CRG90555.1 - 1.5 7.7 7.8 1.7 7.5 7.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Rgp1 PF08737.10 CRG90555.1 - 2.1 7.4 7.8 2.8 7.0 7.8 1.1 1 0 0 1 1 1 0 Rgp1 Menin PF05053.13 CRG90555.1 - 2.4 6.4 7.7 2.8 6.2 7.7 1.2 1 0 0 1 1 1 0 Menin D5_N PF08706.11 CRG90555.1 - 4.8 7.4 8.8 9.4 6.5 8.8 1.6 1 1 0 1 1 1 0 D5 N terminal like MFAP1 PF06991.11 CRG90555.1 - 5.3 6.8 31.0 5.1 6.9 29.4 1.7 1 1 1 2 2 2 0 Microfibril-associated/Pre-mRNA processing Med22 PF06179.12 CRG90556.1 - 7.3e-18 64.7 1.2 8.5e-18 64.5 1.2 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex GPW_gp25 PF04965.14 CRG90556.1 - 0.0097 15.6 0.5 0.035 13.9 0.0 1.9 2 0 0 2 2 2 1 Gene 25-like lysozyme PdaC PF13739.6 CRG90556.1 - 0.11 13.4 2.0 0.3 12.1 0.0 1.9 2 0 0 2 2 2 0 Deacetylase PdaC DHFR_1 PF00186.19 CRG90557.1 - 8.3e-19 67.8 0.1 3.4e-09 36.6 0.0 3.5 2 1 1 3 3 3 3 Dihydrofolate reductase Voltage_CLC PF00654.20 CRG90558.1 - 1.9e-85 287.2 24.9 1.9e-85 287.2 24.9 2.1 2 1 0 2 2 2 1 Voltage gated chloride channel DUF3198 PF11433.8 CRG90558.1 - 0.1 12.5 0.6 0.19 11.6 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) Methyltransf_25 PF13649.6 CRG90559.1 - 0.00017 22.2 0.1 0.00064 20.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90559.1 - 0.036 14.7 0.1 0.15 12.8 0.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90559.1 - 0.16 11.7 0.1 0.35 10.7 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain AMP-binding PF00501.28 CRG90561.1 - 7.2e-53 179.7 0.0 1e-52 179.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Thioesterase PF00975.20 CRG90561.1 - 4.9e-25 89.0 0.0 3.6e-24 86.2 0.0 2.1 2 0 0 2 2 2 1 Thioesterase domain PP-binding PF00550.25 CRG90561.1 - 3.8e-05 24.0 0.4 0.00012 22.3 0.2 2.0 2 0 0 2 2 2 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.7 CRG90561.1 - 0.00012 22.8 0.0 0.00031 21.4 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG90561.1 - 0.0023 17.3 0.0 0.0043 16.3 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PBP PF01161.20 CRG90562.1 - 1.3e-08 35.3 2.7 1.5e-08 35.1 2.7 1.3 1 1 0 1 1 1 1 Phosphatidylethanolamine-binding protein Lipase_GDSL_2 PF13472.6 CRG90563.1 - 2.2e-27 96.6 0.2 5.3e-27 95.4 0.2 1.6 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG90563.1 - 8.3e-17 61.8 0.0 1e-16 61.6 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase BASP1 PF05466.12 CRG90564.1 - 2.6 8.0 14.1 4.5 7.2 14.1 1.3 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) Isochorismatase PF00857.20 CRG90565.1 - 1.3e-17 64.5 0.1 1.7e-17 64.1 0.1 1.2 1 0 0 1 1 1 1 Isochorismatase family PTS_IIA PF02255.16 CRG90565.1 - 0.0039 17.2 0.1 0.58 10.2 0.0 2.1 2 0 0 2 2 2 2 PTS system, Lactose/Cellobiose specific IIA subunit FAM25 PF15825.5 CRG90565.1 - 0.052 13.9 0.0 0.09 13.1 0.0 1.4 1 0 0 1 1 1 0 FAM25 family Glyco_transf_4 PF13439.6 CRG90565.1 - 0.086 12.8 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 HK PF02110.15 CRG90566.1 - 2.2e-68 230.3 1.4 2.2e-68 230.3 1.4 1.6 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 CRG90566.1 - 6.2e-54 182.1 2.5 1.1e-53 181.2 2.5 1.4 1 0 0 1 1 1 1 Thiamine monophosphate synthase eIF-5_eIF-2B PF01873.17 CRG90567.1 - 8.8e-40 135.2 0.0 1.6e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 CRG90567.1 - 2.6e-21 75.5 0.1 2.6e-21 75.5 0.1 2.2 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Ctr PF04145.15 CRG90568.1 - 0.65 10.6 3.5 0.98 10.0 1.1 2.4 2 0 0 2 2 2 0 Ctr copper transporter family RRN3 PF05327.11 CRG90568.1 - 2.2 6.7 9.1 0.069 11.7 1.2 2.3 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_ligase_A_M PF01068.21 CRG90569.1 - 2.6e-59 200.3 0.1 2.9e-46 157.7 0.1 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 CRG90569.1 - 2.4e-43 148.5 0.0 5.5e-43 147.3 0.0 1.7 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 CRG90569.1 - 1.3e-28 99.5 0.0 5.1e-28 97.6 0.0 2.1 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 CRG90569.1 - 7.5e-05 23.1 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 RNA ligase Synaptonemal_3 PF15191.6 CRG90569.1 - 0.11 12.2 0.0 0.31 10.8 0.0 1.7 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 mRNA_cap_enzyme PF01331.19 CRG90570.1 - 1.1e-52 178.7 0.4 1.7e-52 178.1 0.4 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 CRG90570.1 - 9.6e-37 125.9 0.1 1.9e-36 125.0 0.1 1.5 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 CRG90570.1 - 7.2e-08 32.3 0.4 6.4e-06 26.0 0.3 2.4 1 1 1 2 2 2 2 ATP dependent DNA ligase domain SCA7 PF08313.12 CRG90571.1 - 9.7e-31 105.5 1.1 2.8e-30 104.0 1.1 1.9 1 0 0 1 1 1 1 SCA7, zinc-binding domain CDC45 PF02724.14 CRG90571.1 - 0.12 10.7 10.9 0.15 10.3 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 CRG90571.1 - 0.32 9.5 5.8 0.46 9.0 5.8 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator ketoacyl-synt PF00109.26 CRG90572.1 - 9.8e-59 199.0 3.7 5.7e-58 196.5 0.3 2.0 2 0 0 2 2 2 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CRG90572.1 - 1.3e-33 115.5 2.7 2.4e-33 114.6 2.7 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 CRG90572.1 - 4e-05 23.1 1.1 0.00087 18.7 0.1 2.2 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG90572.1 - 0.0091 15.6 4.4 0.028 14.1 0.7 2.8 2 1 0 2 2 2 1 Thiolase, C-terminal domain Arginase PF00491.21 CRG90573.1 - 3.4e-90 302.3 0.0 4.1e-90 302.1 0.0 1.1 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CRG90573.1 - 0.0064 16.7 0.0 0.011 16.0 0.0 1.3 1 0 0 1 1 1 1 UPF0489 domain Ras PF00071.22 CRG90574.1 - 2.7e-50 170.1 0.0 4.6e-50 169.4 0.0 1.4 1 0 0 1 1 1 1 Ras family DUF1349 PF07081.11 CRG90574.1 - 1.2e-24 87.0 0.0 2e-24 86.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Roc PF08477.13 CRG90574.1 - 3.1e-17 62.9 0.0 8.7e-17 61.5 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MFS_1 PF07690.16 CRG90574.1 - 6.3e-17 61.5 38.9 3.6e-16 59.0 37.0 2.7 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG90574.1 - 1.8e-07 30.0 17.6 2.8e-07 29.4 17.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CAP59_mtransfer PF11735.8 CRG90575.1 - 6.3e-69 232.3 0.0 8.2e-69 231.9 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 ArabFuran-catal PF09206.11 CRG90576.1 - 2.4e-131 437.7 9.0 3.5e-131 437.2 9.0 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 CRG90576.1 - 1.7e-53 180.4 2.1 2.8e-53 179.7 2.1 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Iwr1 PF08574.10 CRG90578.1 - 1.8e-20 73.7 7.6 1.8e-20 73.7 7.6 4.5 4 1 0 4 4 4 1 Transcription factor Iwr1 Atg29_N PF18388.1 CRG90578.1 - 0.082 12.7 1.9 0.29 11.0 0.0 2.4 2 0 0 2 2 2 0 Atg29 N-terminal domain LRR19-TM PF15176.6 CRG90578.1 - 1.3 9.1 0.0 1.3 9.1 0.0 2.8 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain IFT57 PF10498.9 CRG90578.1 - 2.4 7.1 14.9 0.09 11.7 1.3 3.0 3 1 0 3 3 3 0 Intra-flagellar transport protein 57 RRM_1 PF00076.22 CRG90579.1 - 1.7e-38 130.3 0.0 2.6e-12 46.4 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 CRG90579.1 - 1.3e-13 50.6 0.0 0.0018 18.1 0.0 4.3 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM_7 PF16367.5 CRG90579.1 - 1.7e-06 28.0 0.0 0.0061 16.6 0.0 3.5 3 0 0 3 3 3 2 RNA recognition motif RRM PF10378.9 CRG90579.1 - 1.6e-05 24.5 1.4 1.6e-05 24.5 1.4 2.8 2 0 0 2 2 2 1 Putative RRM domain DUF4523 PF15023.6 CRG90579.1 - 0.00089 19.1 0.0 0.64 9.8 0.0 3.1 3 0 0 3 3 3 1 Protein of unknown function (DUF4523) RRM_3 PF08777.11 CRG90579.1 - 0.0026 17.8 0.0 0.57 10.3 0.0 3.0 3 0 0 3 3 3 1 RNA binding motif RRM_Rrp7 PF17799.1 CRG90579.1 - 0.023 14.5 0.0 1.8 8.3 0.0 3.1 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain Spo7_2_N PF15407.6 CRG90579.1 - 0.15 11.7 0.0 5.9 6.6 0.0 2.7 3 0 0 3 3 3 0 Sporulation protein family 7 tRNA-synt_2 PF00152.20 CRG90580.1 - 1.4e-88 297.0 0.0 1.8e-88 296.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 CRG90580.1 - 5e-08 32.8 0.0 1e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ecl1 PF12855.7 CRG90581.1 - 4.4e-48 164.7 20.8 4.4e-48 164.7 20.8 2.6 2 0 0 2 2 2 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 CRG90581.1 - 0.016 15.3 3.8 0.036 14.2 3.8 1.5 1 0 0 1 1 1 0 MYND finger zf-FLZ PF04570.14 CRG90581.1 - 0.21 11.1 5.3 0.8 9.2 5.3 1.8 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 DUF2256 PF10013.9 CRG90581.1 - 1 9.5 6.3 7.8 6.7 6.3 2.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Macoilin PF09726.9 CRG90581.1 - 1 7.8 4.6 1.3 7.5 4.6 1.3 1 0 0 1 1 1 0 Macoilin family p450 PF00067.22 CRG90582.1 - 7.1e-37 127.2 0.0 7.8e-37 127.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 YL1 PF05764.13 CRG90583.1 - 1.1e-59 202.5 37.4 1.1e-59 202.5 37.4 3.5 3 0 0 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 CRG90583.1 - 2.8e-10 39.8 0.1 4.7e-10 39.0 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Glyco_hydro_18 PF00704.28 CRG90584.1 - 2.7e-45 155.5 7.2 2.7e-45 155.5 7.2 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 LysM PF01476.20 CRG90584.1 - 4.3e-08 33.1 0.1 0.014 15.4 0.0 3.4 3 0 0 3 3 3 2 LysM domain Chitin_bind_1 PF00187.19 CRG90584.1 - 0.00028 21.3 6.4 0.00028 21.3 6.4 3.8 4 0 0 4 4 4 1 Chitin recognition protein Ank PF00023.30 CRG90586.1 - 0.021 15.3 0.2 27 5.4 0.0 3.8 3 1 0 3 3 3 0 Ankyrin repeat PUF PF00806.19 CRG90587.1 - 2.2e-28 96.3 0.4 2.5e-05 23.7 0.0 6.7 7 0 0 7 7 7 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 CRG90587.1 - 8.2e-11 41.6 0.0 1.7e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bac_rhamnosid_C PF17390.2 CRG90588.1 - 5.1e-17 61.4 0.5 4.7e-16 58.3 0.3 2.5 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase C-terminal domain Bac_rhamnosid6H PF17389.2 CRG90588.1 - 6.8e-17 61.7 3.4 6e-16 58.6 1.9 2.1 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain DUF608 PF04685.13 CRG90588.1 - 5.5e-06 25.8 3.6 8.6e-06 25.1 3.6 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region Trehalase PF01204.18 CRG90588.1 - 5.9e-05 22.1 0.4 9.6e-05 21.4 0.4 1.2 1 0 0 1 1 1 1 Trehalase Glyco_hydro_36 PF17167.4 CRG90588.1 - 7.5e-05 21.6 0.1 0.00013 20.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase 36 superfamily, catalytic domain Bac_rhamnosid PF05592.11 CRG90588.1 - 7.8e-05 22.6 0.0 0.0002 21.3 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain GDE_C PF06202.14 CRG90588.1 - 0.00026 20.1 0.9 0.00061 18.8 0.9 1.6 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Glyco_hydro_100 PF12899.7 CRG90588.1 - 0.09 11.4 0.1 0.5 9.0 0.1 1.9 2 0 0 2 2 2 0 Alkaline and neutral invertase MT-A70 PF05063.14 CRG90589.1 - 1.3e-24 87.1 0.1 2e-24 86.4 0.1 1.3 1 0 0 1 1 1 1 MT-A70 Cons_hypoth95 PF03602.15 CRG90589.1 - 0.12 12.0 0.1 0.46 10.1 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Peptidase_C12 PF01088.21 CRG90590.1 - 1.1e-51 175.6 0.0 1.8e-51 174.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 DcpS_C PF11969.8 CRG90590.1 - 9.1e-31 106.7 0.1 2.5e-30 105.3 0.1 1.7 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 CRG90590.1 - 1.5e-29 102.8 0.0 2.9e-29 102.0 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal RNase_H2_suC PF08615.11 CRG90590.1 - 4.1e-27 95.1 0.0 8.2e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Nop53 PF07767.11 CRG90591.1 - 2e-105 353.5 34.7 2e-105 353.5 34.7 2.9 3 0 0 3 3 3 1 Nop53 (60S ribosomal biogenesis) RNase_T PF00929.24 CRG90591.1 - 4e-20 73.0 0.0 7.2e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Exonuclease Myb_Cef PF11831.8 CRG90592.1 - 3.9e-54 183.7 0.2 3.9e-54 183.7 0.2 3.5 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 CRG90592.1 - 1.1e-21 76.8 4.5 7.5e-11 42.0 0.7 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG90592.1 - 2.3e-20 72.6 3.3 1.9e-13 50.4 0.7 3.0 2 1 1 3 3 3 2 Myb-like DNA-binding domain Rap1_C PF11626.8 CRG90592.1 - 0.048 13.8 2.0 0.22 11.6 0.0 3.0 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MOZ_SAS PF01853.18 CRG90593.1 - 2.8e-78 261.7 0.0 4.1e-78 261.2 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.8 CRG90593.1 - 6.7e-23 80.3 0.0 1.3e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-MYST PF17772.1 CRG90593.1 - 3.9e-22 77.6 0.2 8.8e-22 76.5 0.2 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 CRG90593.1 - 0.0034 17.8 0.0 0.0065 16.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG90593.1 - 0.034 14.4 0.1 0.092 13.0 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family F1F0-ATPsyn_F PF10791.9 CRG90595.1 - 2.9e-34 117.4 4.7 3.7e-33 113.9 4.7 1.9 1 1 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi ETC_C1_NDUFA4 PF04800.12 CRG90596.1 - 7.4e-37 125.5 2.3 9.8e-37 125.1 2.3 1.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region HEAT_2 PF13646.6 CRG90597.1 - 1.9e-30 105.1 2.6 7.8e-14 51.8 0.2 3.9 2 2 1 4 4 4 2 HEAT repeats HEAT_PBS PF03130.16 CRG90597.1 - 7.6e-21 72.6 0.1 0.00094 19.6 0.0 6.4 7 0 0 7 7 7 5 PBS lyase HEAT-like repeat HEAT PF02985.22 CRG90597.1 - 5.2e-08 32.5 1.7 1.5 9.3 0.0 6.0 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 CRG90597.1 - 5.8e-05 23.5 7.2 2.3 8.8 0.0 5.6 3 2 4 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 CRG90597.1 - 0.0067 16.5 0.0 4.5 7.3 0.0 3.0 2 2 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 CRG90597.1 - 0.011 15.8 0.0 0.22 11.6 0.0 2.7 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat RuvA_C PF07499.13 CRG90597.1 - 0.022 15.2 2.8 7.4 7.1 0.1 3.4 4 0 0 4 4 4 0 RuvA, C-terminal domain GlnD_UR_UTase PF08335.11 CRG90597.1 - 0.085 13.0 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 GlnD PII-uridylyltransferase Nipped-B_C PF12830.7 CRG90598.1 - 2.2e-47 161.5 6.4 1e-46 159.3 1.0 3.8 3 1 1 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 CRG90598.1 - 7.2e-12 45.4 2.3 2.4e-11 43.7 2.3 2.0 1 0 0 1 1 1 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 CRG90598.1 - 0.0015 18.6 4.4 0.77 10.2 0.3 4.7 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 CRG90598.1 - 0.0015 17.1 6.6 0.05 12.2 0.9 3.2 2 1 1 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 CRG90598.1 - 0.018 15.1 0.6 0.12 12.4 0.0 2.7 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Pyr_redox_2 PF07992.14 CRG90599.1 - 9e-43 146.6 0.0 1.4e-42 145.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG90599.1 - 1.3e-10 41.6 2.9 9.7e-10 38.9 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 CRG90599.1 - 7.1e-07 28.3 0.2 2.3e-06 26.8 0.1 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 CRG90599.1 - 2e-05 24.1 0.5 6.6e-05 22.5 0.5 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 CRG90599.1 - 6.9e-05 23.2 0.1 0.00017 22.0 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 CRG90599.1 - 0.00095 18.6 0.6 0.002 17.6 0.2 1.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 CRG90599.1 - 0.03 14.2 0.2 0.1 12.4 0.1 1.9 2 0 0 2 2 2 0 EF-hand domain pair Pyr_redox_3 PF13738.6 CRG90599.1 - 0.032 13.5 1.8 0.28 10.4 1.0 2.3 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CLTH PF10607.9 CRG90600.1 - 2.9e-32 111.6 0.0 3.7e-32 111.3 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 CRG90600.1 - 1.7e-08 34.1 0.0 3.7e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 LisH LisH_2 PF16045.5 CRG90600.1 - 0.046 12.8 0.0 0.089 11.8 0.0 1.4 1 0 0 1 1 1 0 LisH PRK PF00485.18 CRG90601.1 - 2.8e-56 190.4 0.0 4.4e-56 189.7 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 CRG90601.1 - 6.1e-44 149.9 0.1 1.1e-43 149.1 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 CRG90601.1 - 0.00048 20.7 0.0 0.0012 19.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 CRG90601.1 - 0.0037 17.1 0.0 0.0074 16.1 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 CRG90601.1 - 0.035 14.3 0.1 0.087 13.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 CRG90601.1 - 0.041 13.2 0.0 0.083 12.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 CRG90601.1 - 0.071 13.5 0.0 0.29 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 CRG90601.1 - 0.073 13.6 0.0 0.95 10.0 0.0 2.2 2 0 0 2 2 2 0 ABC transporter DUF87 PF01935.17 CRG90601.1 - 0.13 12.3 0.1 0.32 11.1 0.0 1.6 2 0 0 2 2 2 0 Helicase HerA, central domain APS_kinase PF01583.20 CRG90601.1 - 0.17 11.8 0.0 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_17 PF13207.6 CRG90601.1 - 0.17 12.3 1.9 3.9 7.9 0.2 3.1 2 1 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 CRG90601.1 - 2.8 7.6 4.6 6.8 6.4 0.1 3.1 2 2 1 3 3 3 0 Cytidylate kinase NUC153 PF08159.12 CRG90602.1 - 4.4e-14 52.0 1.0 4.4e-14 52.0 1.0 3.4 3 0 0 3 3 3 1 NUC153 domain GARP PF16731.5 CRG90602.1 - 0.44 10.2 14.0 0.11 12.1 6.9 2.6 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma OsmC PF02566.19 CRG90603.1 - 1.9e-12 47.5 0.0 2.6e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 OsmC-like protein DAO PF01266.24 CRG90604.1 - 6.8e-29 101.5 0.0 8.8e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG90604.1 - 9.9e-06 25.7 0.0 2.7e-05 24.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG90604.1 - 4e-05 23.0 0.0 0.017 14.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG90604.1 - 0.0016 19.0 0.0 0.0056 17.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90604.1 - 0.0029 17.6 0.3 0.099 12.6 0.0 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_2 PF03446.15 CRG90604.1 - 0.0029 17.8 0.0 0.011 16.0 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CRG90604.1 - 0.0051 16.7 0.0 0.0077 16.1 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CRG90604.1 - 0.0051 16.8 0.0 0.014 15.4 0.0 1.7 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Adeno_PVIII PF01310.18 CRG90604.1 - 0.0066 16.1 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Adenovirus hexon associated protein, protein VIII ApbA PF02558.16 CRG90604.1 - 0.016 14.9 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 CRG90604.1 - 0.018 14.2 0.0 0.35 9.9 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Shikimate_DH PF01488.20 CRG90604.1 - 0.022 14.9 0.0 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 CRG90604.1 - 0.075 12.3 0.0 1.7 7.8 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG90604.1 - 0.13 11.4 0.0 0.48 9.5 0.0 1.8 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 CRG90604.1 - 0.15 10.7 0.2 0.81 8.3 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein TrkA_N PF02254.18 CRG90604.1 - 0.21 11.9 0.0 0.69 10.2 0.0 1.9 2 1 0 3 3 2 0 TrkA-N domain MFS_1 PF07690.16 CRG90605.1 - 3.5e-24 85.4 17.8 3.5e-24 85.4 17.8 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily FNIP_N PF14636.6 CRG90606.1 - 1.4e-33 117.0 0.1 1.4e-33 117.0 0.1 3.6 4 1 0 4 4 4 1 Folliculin-interacting protein N-terminus IML1 PF12257.8 CRG90607.1 - 1.3e-111 372.3 0.0 2.5e-111 371.4 0.0 1.5 2 0 0 2 2 2 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 CRG90607.1 - 1.9e-25 88.7 0.3 3.4e-25 87.9 0.3 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) MerR_1 PF13411.6 CRG90607.1 - 0.008 16.3 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 MerR HTH family regulatory protein SLT PF01464.20 CRG90608.1 - 3.2e-10 39.7 0.8 8.9e-10 38.3 0.8 1.7 1 1 0 1 1 1 1 Transglycosylase SLT domain Kelch_5 PF13854.6 CRG90610.1 - 1.2e-06 28.4 0.1 1.2e-06 28.4 0.1 4.4 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 CRG90610.1 - 3.7e-05 23.5 11.1 0.11 12.5 0.1 5.5 6 0 0 6 6 6 3 Kelch motif Phage_HK97_TLTM PF06120.11 CRG90610.1 - 0.0022 17.2 0.2 0.0035 16.6 0.2 1.2 1 0 0 1 1 1 1 Tail length tape measure protein Kelch_1 PF01344.25 CRG90610.1 - 0.005 16.4 15.3 0.45 10.1 0.3 5.5 7 0 0 7 7 7 3 Kelch motif SKG6 PF08693.10 CRG90610.1 - 0.0058 16.0 0.7 0.013 14.9 0.7 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Kelch_6 PF13964.6 CRG90610.1 - 0.19 12.1 7.5 52 4.3 0.0 5.3 5 0 0 5 5 5 0 Kelch motif MGC-24 PF05283.11 CRG90610.1 - 0.36 11.3 3.4 0.77 10.2 3.4 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Herpes_pp85 PF04637.12 CRG90610.1 - 2.8 6.3 4.1 4 5.7 4.1 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Na_Ca_ex PF01699.24 CRG90611.1 - 6.5e-46 156.0 37.3 1.4e-24 86.8 18.0 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3720 PF12517.8 CRG90611.1 - 0.019 15.9 1.1 0.05 14.5 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) Fungal_trans PF04082.18 CRG90612.1 - 1.4e-21 76.7 0.0 2.4e-21 76.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90612.1 - 0.00015 21.8 7.6 0.00026 21.0 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP_Ca_trans_C PF12424.8 CRG90612.1 - 0.12 12.9 0.5 0.56 10.7 0.0 2.4 2 0 0 2 2 2 0 Plasma membrane calcium transporter ATPase C terminal Npa1 PF11707.8 CRG90615.1 - 1.5e-96 323.8 3.2 1.4e-95 320.6 0.3 3.0 2 1 0 3 3 3 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 CRG90615.1 - 1.4e-58 197.8 0.3 2.1e-57 194.0 0.0 3.1 3 0 0 3 3 3 1 Nucleolar pre-ribosomal-associated protein 1 Creb_binding PF09030.10 CRG90615.1 - 0.019 15.7 0.8 0.11 13.2 0.0 2.7 3 0 0 3 3 3 0 Creb binding RICTOR_M PF14666.6 CRG90615.1 - 0.026 14.3 0.7 71 3.2 0.0 4.7 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR, middle domain Arm PF00514.23 CRG90615.1 - 0.067 13.3 0.1 15 5.8 0.0 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat G-patch PF01585.23 CRG90616.1 - 0.0014 18.5 0.7 0.0025 17.7 0.1 1.8 2 0 0 2 2 2 1 G-patch domain CTU2 PF10288.9 CRG90616.1 - 4.1 7.7 12.6 7.1 6.9 7.2 2.9 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Sec1 PF00995.23 CRG90617.1 - 2.9e-119 399.9 0.0 3.6e-119 399.6 0.0 1.1 1 0 0 1 1 1 1 Sec1 family SUV3_C PF12513.8 CRG90618.1 - 1e-17 63.8 0.3 2.4e-17 62.6 0.3 1.7 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 CRG90618.1 - 1.5e-10 41.4 0.1 3.1e-09 37.2 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 CRG90618.1 - 2.4e-07 30.5 0.3 7.7e-07 28.9 0.1 2.1 2 0 0 2 2 2 1 Suv3 C-terminal domain 1 DUF4771 PF15995.5 CRG90618.1 - 0.022 15.0 0.3 0.051 13.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) adh_short PF00106.25 CRG90619.1 - 3.7e-13 49.4 0.0 3.1e-12 46.4 0.0 2.4 2 2 1 3 3 3 1 short chain dehydrogenase KR PF08659.10 CRG90619.1 - 8.7e-06 25.8 0.1 2.6e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 CRG90619.1 - 2.1e-05 24.2 0.0 7.6e-05 22.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CRG90619.1 - 0.0054 16.2 0.0 0.018 14.5 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CRG90619.1 - 0.03 13.4 0.1 0.22 10.6 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CRG90620.1 - 1.6e-50 172.4 0.0 4.9e-50 170.8 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CRG90620.1 - 2.6e-46 158.1 0.0 3.6e-46 157.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG90620.1 - 9.2e-15 54.4 0.0 1.2e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CRG90620.1 - 2.6e-12 46.4 0.0 3.7e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 CRG90620.1 - 3.8e-12 45.9 0.0 1.6e-10 40.6 0.0 2.1 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CRG90620.1 - 1.8e-09 37.3 0.0 3.6e-09 36.4 0.0 1.4 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG90620.1 - 1.3e-06 28.4 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 CRG90620.1 - 0.00022 20.5 0.1 0.0029 16.8 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 CRG90620.1 - 0.00051 20.0 0.0 0.00078 19.4 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding adh_short_C2 PF13561.6 CRG90620.1 - 0.0024 17.5 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 CRG90620.1 - 0.068 12.7 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family Glyco_transf_15 PF01793.16 CRG90621.1 - 3.5e-130 434.0 8.6 4.3e-130 433.7 8.6 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase PAT1 PF09770.9 CRG90622.1 - 0 1180.6 0.4 0 1180.4 0.4 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Erf4 PF10256.9 CRG90622.1 - 0.083 13.0 0.0 0.33 11.1 0.0 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family T3SS_needle_F PF09392.10 CRG90622.1 - 2.9 8.1 5.0 6.6 7.0 0.7 2.9 3 0 0 3 3 3 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Ribosom_S12_S23 PF00164.25 CRG90623.1 - 9.2e-30 102.6 0.9 1.4e-29 102.0 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S12/S23 UMP1 PF05348.11 CRG90624.1 - 7.6e-37 126.1 0.0 9.6e-37 125.8 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Rad60-SLD_2 PF13881.6 CRG90625.1 - 1.5e-12 47.6 0.0 3.1e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CRG90625.1 - 0.00054 20.5 0.0 0.0016 19.0 0.0 1.7 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 CRG90625.1 - 0.062 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family SAPS PF04499.15 CRG90625.1 - 1.4 7.6 3.5 1.9 7.2 3.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GHMP_kinases_N PF00288.26 CRG90626.1 - 1.1e-13 51.2 1.6 2.7e-13 49.9 1.6 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 CRG90626.1 - 1e-10 41.8 0.3 3e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 GHMP kinases C terminal Complex1_LYR_2 PF13233.6 CRG90626.1 - 0.071 13.9 0.7 0.071 13.9 0.7 2.1 2 0 0 2 2 2 0 Complex1_LYR-like DUF3391 PF11871.8 CRG90626.1 - 0.9 10.1 5.2 5.9 7.4 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) PPR_2 PF13041.6 CRG90627.1 - 1.7e-43 146.6 6.6 5.5e-09 36.1 0.0 13.5 10 4 5 15 15 15 6 PPR repeat family PPR_3 PF13812.6 CRG90627.1 - 1.2e-27 95.8 0.1 0.0059 16.7 0.0 10.2 7 3 4 11 11 11 7 Pentatricopeptide repeat domain PPR PF01535.20 CRG90627.1 - 1.8e-23 81.1 25.0 0.00084 19.4 0.0 15.1 18 2 0 18 18 18 6 PPR repeat PPR_1 PF12854.7 CRG90627.1 - 9e-23 79.7 0.3 5.1e-06 26.1 0.1 10.7 11 1 0 11 11 11 5 PPR repeat PPR_long PF17177.4 CRG90627.1 - 8.3e-19 67.8 18.1 2e-08 33.9 0.2 7.4 4 2 4 8 8 8 5 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 CRG90627.1 - 2.9e-09 37.3 0.0 5.9e-07 29.9 0.0 4.1 5 0 0 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) RPN7 PF10602.9 CRG90627.1 - 0.061 13.0 0.3 1.7 8.4 0.1 3.1 1 1 1 3 3 3 0 26S proteasome subunit RPN7 DEC-1_N PF04625.13 CRG90628.1 - 0.088 11.8 3.3 0.096 11.7 3.3 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region GDNF PF02351.16 CRG90628.1 - 0.09 13.8 7.1 0.13 13.3 7.1 1.2 1 0 0 1 1 1 0 GDNF/GAS1 domain Rieske PF00355.26 CRG90629.1 - 1.8e-10 40.6 0.0 3.1e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 CRG90629.1 - 3.4e-10 40.2 0.4 7.3e-10 39.2 0.4 1.6 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region CBFD_NFYB_HMF PF00808.23 CRG90630.1 - 9e-15 54.7 0.1 1.5e-14 54.0 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 CRG90630.1 - 0.0029 18.0 0.2 0.005 17.2 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 ABC_tran PF00005.27 CRG90631.1 - 0.0054 17.2 0.1 0.0073 16.8 0.1 1.2 1 0 0 1 1 1 1 ABC transporter 3-PAP PF12578.8 CRG90631.1 - 0.031 14.0 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-associated protein Baculo_F PF12259.8 CRG90631.1 - 0.071 11.6 0.0 0.074 11.6 0.0 1.0 1 0 0 1 1 1 0 Baculovirus F protein Voltage_CLC PF00654.20 CRG90632.1 - 5.1e-89 299.0 27.0 5.1e-89 299.0 27.0 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 CRG90632.1 - 1.6e-12 47.7 0.0 0.00011 22.6 0.0 2.6 2 0 0 2 2 2 2 CBS domain EamA PF00892.20 CRG90633.1 - 0.0011 19.1 15.7 0.01 16.0 15.7 1.9 1 1 0 1 1 1 1 EamA-like transporter family TMEM234 PF10639.9 CRG90633.1 - 0.004 17.2 1.0 0.0055 16.7 1.0 1.2 1 0 0 1 1 1 1 Putative transmembrane family 234 Astro_capsid_p PF12226.8 CRG90633.1 - 0.017 14.3 3.1 0.02 14.1 3.1 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Nop14 PF04147.12 CRG90633.1 - 0.06 11.6 12.4 0.071 11.3 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 CRG90633.1 - 0.062 13.2 6.0 0.1 12.4 6.0 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Vac7 PF12751.7 CRG90633.1 - 0.44 9.9 3.2 0.63 9.4 3.2 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 SDA1 PF05285.12 CRG90633.1 - 2.7 7.3 15.5 3.2 7.1 15.5 1.1 1 0 0 1 1 1 0 SDA1 FYDLN_acid PF09538.10 CRG90633.1 - 4.4 8.0 14.8 6.7 7.4 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) CobT PF06213.12 CRG90633.1 - 4.9 6.5 16.8 6.8 6.0 16.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT COPI_C PF06957.11 CRG90633.1 - 5.1 5.8 8.0 8.7 5.0 8.0 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus TRAP_alpha PF03896.16 CRG90633.1 - 8.2 5.5 8.5 12 4.9 8.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sporozoite_P67 PF05642.11 CRG90633.1 - 9.1 4.2 11.5 12 3.8 11.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RXT2_N PF08595.11 CRG90633.1 - 10 6.2 10.9 17 5.4 10.9 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal PNP_phzG_C PF10590.9 CRG90634.1 - 1.6e-21 76.1 2.6 1.6e-21 76.1 2.6 2.6 3 0 0 3 3 3 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 CRG90634.1 - 1.2e-08 35.0 0.0 0.00027 21.1 0.0 2.3 2 0 0 2 2 2 2 Pyridoxamine 5'-phosphate oxidase Rav1p_C PF12234.8 CRG90634.1 - 0.063 11.7 0.6 0.088 11.2 0.6 1.1 1 0 0 1 1 1 0 RAVE protein 1 C terminal ThiJ_like PF17124.5 CRG90635.1 - 6.7e-58 195.6 0.0 8e-58 195.4 0.0 1.0 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 CRG90635.1 - 6.8e-10 39.0 0.0 6.3e-09 35.8 0.0 2.1 2 1 0 2 2 2 1 DJ-1/PfpI family DUF5543 PF17697.1 CRG90635.1 - 0.096 13.0 0.0 0.34 11.2 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5543) UPF0052 PF01933.18 CRG90636.1 - 2.6e-60 204.2 0.0 3.2e-60 203.9 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 zf-C3HC4 PF00097.25 CRG90637.1 - 4.3e-09 36.1 6.7 7.3e-09 35.4 6.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG90637.1 - 5.1e-09 35.9 8.9 1.2e-08 34.7 8.9 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG90637.1 - 1.2e-08 34.8 0.8 2e-08 34.1 0.4 1.6 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CRG90637.1 - 3.4e-08 33.2 4.2 3.4e-08 33.2 4.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG90637.1 - 2e-07 31.2 6.2 3.9e-07 30.3 6.2 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 CRG90637.1 - 3.4e-06 26.9 6.6 6.4e-06 26.0 6.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG90637.1 - 0.0002 21.2 7.8 0.0017 18.2 7.8 2.1 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 CRG90637.1 - 0.00041 20.4 4.2 0.0012 19.0 4.3 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 CRG90637.1 - 0.15 12.2 4.4 0.5 10.6 4.4 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 CRG90637.1 - 0.16 11.8 6.9 0.39 10.6 6.9 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 CRG90637.1 - 0.56 10.5 7.5 5.4 7.4 8.2 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CRG90637.1 - 0.73 9.6 7.0 2 8.3 7.0 1.8 1 1 0 1 1 1 0 RING-like zinc finger FYVE PF01363.21 CRG90637.1 - 1.8 8.7 6.7 7.1 6.9 6.7 2.0 1 1 0 1 1 1 0 FYVE zinc finger DNApol_Exo PF18136.1 CRG90638.1 - 4.1e-107 357.5 0.0 6.8e-107 356.8 0.0 1.3 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 CRG90638.1 - 9.6e-58 196.0 0.0 2.1e-57 194.9 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 CRG90638.1 - 0.097 12.4 0.2 0.9 9.2 0.2 2.3 1 1 0 1 1 1 0 3'-5' exonuclease Mad3_BUB1_I PF08311.12 CRG90638.1 - 0.11 12.4 0.4 0.3 11.1 0.4 1.6 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 DUF1138 PF06592.13 CRG90638.1 - 0.18 11.9 0.2 0.66 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1138) CorA PF01544.18 CRG90639.1 - 5.7e-28 98.1 5.0 2.8e-18 66.2 0.5 3.1 3 0 0 3 3 3 3 CorA-like Mg2+ transporter protein SQS_PSY PF00494.19 CRG90640.1 - 2.2e-51 174.9 0.0 3.1e-51 174.4 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase SNF2_N PF00176.23 CRG90641.1 - 8.4e-71 238.5 0.0 1.2e-70 238.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 CRG90641.1 - 6.4e-23 80.5 0.0 1.4e-22 79.4 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 CRG90641.1 - 8.5e-15 55.1 0.0 1.9e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 CRG90641.1 - 0.00015 21.5 5.7 0.00027 20.7 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG90641.1 - 0.00028 20.7 8.0 0.00053 19.8 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG90641.1 - 0.00034 20.4 4.2 0.00078 19.2 4.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG90641.1 - 0.0029 17.9 8.1 0.007 16.7 8.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 CRG90641.1 - 0.0031 17.5 8.3 0.0067 16.4 8.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger PLU-1 PF08429.11 CRG90641.1 - 0.0087 15.3 1.2 0.016 14.4 1.2 1.3 1 0 0 1 1 1 1 PLU-1-like protein zf-RING_5 PF14634.6 CRG90641.1 - 0.034 14.1 6.7 0.069 13.1 6.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 CRG90641.1 - 0.079 13.1 7.6 0.15 12.2 7.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING UBA_4 PF14555.6 CRG90641.1 - 0.095 12.5 0.0 0.49 10.2 0.0 2.2 2 0 0 2 2 2 0 UBA-like domain Ribonuc_red_sm PF00268.21 CRG90642.1 - 6.5e-122 406.3 0.5 7.8e-122 406.1 0.5 1.0 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Mito_carr PF00153.27 CRG90643.1 - 1.1e-52 176.0 3.3 1.2e-18 66.8 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 CRG90644.1 - 3.7e-14 52.9 2.3 3.2e-06 27.8 0.3 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90644.1 - 3e-07 30.7 0.0 0.0014 18.9 0.0 3.5 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 CRG90644.1 - 0.011 14.3 0.1 3.5 6.1 0.0 3.2 3 1 0 4 4 4 0 Cytochrome D1 heme domain WDCP PF15390.6 CRG90644.1 - 0.042 12.2 0.0 0.12 10.8 0.0 1.6 2 0 0 2 2 2 0 WD repeat and coiled-coil-containing protein family Nucleoporin_N PF08801.11 CRG90644.1 - 0.066 11.9 0.4 0.31 9.7 0.1 1.9 1 1 1 2 2 2 0 Nup133 N terminal like TrpBP PF02081.15 CRG90644.1 - 0.13 12.1 0.1 0.29 11.0 0.1 1.5 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein DUF1308 PF07000.11 CRG90645.1 - 4.8e-11 42.9 1.9 6.2e-10 39.2 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1308) DUF4407 PF14362.6 CRG90645.1 - 0.062 12.6 0.9 0.09 12.1 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BTV_NS2 PF04514.12 CRG90645.1 - 7.5 5.3 8.0 12 4.6 0.8 2.2 2 0 0 2 2 2 0 Bluetongue virus non-structural protein NS2 Lung_7-TM_R PF06814.13 CRG90646.1 - 9e-73 245.1 15.2 1.1e-72 244.8 15.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Ost5 PF05251.12 CRG90646.1 - 0.02 15.1 4.5 6.4 7.1 0.3 4.1 3 1 1 4 4 4 0 Oligosaccharyltransferase subunit 5 Frag1 PF10277.9 CRG90646.1 - 0.057 13.0 10.6 0.018 14.6 7.4 1.8 1 1 0 1 1 1 0 Frag1/DRAM/Sfk1 family CTU2 PF10288.9 CRG90647.1 - 1e-11 45.1 1.0 6.7e-10 39.2 0.0 2.3 1 1 1 2 2 2 2 Cytoplasmic tRNA 2-thiolation protein 2 ThiI PF02568.14 CRG90647.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) DUF4112 PF13430.6 CRG90648.1 - 4.8e-35 120.0 0.1 6.2e-35 119.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) DCP2 PF05026.13 CRG90649.1 - 1.6e-30 105.3 0.4 3.3e-30 104.2 0.4 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 CRG90649.1 - 3.3e-17 62.8 0.1 6e-17 61.9 0.1 1.4 1 0 0 1 1 1 1 NUDIX domain eIF-4B PF06273.11 CRG90649.1 - 1.2 8.1 5.2 3.8 6.5 0.3 2.9 3 0 0 3 3 3 0 Plant specific eukaryotic initiation factor 4B GCV_T PF01571.21 CRG90650.1 - 0.0003 20.2 0.0 0.00049 19.6 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DnaJ PF00226.31 CRG90651.1 - 6.6e-19 67.8 1.8 1.8e-18 66.4 0.4 2.4 2 0 0 2 2 2 1 DnaJ domain RRM_1 PF00076.22 CRG90651.1 - 0.019 14.8 0.1 0.055 13.3 0.1 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PseudoU_synth_2 PF00849.22 CRG90651.1 - 0.2 11.7 2.5 15 5.7 0.0 2.4 2 0 0 2 2 2 0 RNA pseudouridylate synthase DUF4523 PF15023.6 CRG90651.1 - 0.21 11.4 1.8 3.9 7.3 0.2 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF4523) Helicase_PWI PF18149.1 CRG90651.1 - 0.54 10.5 9.1 4.4 7.5 0.5 3.4 3 1 0 3 3 3 0 N-terminal helicase PWI domain LDB19 PF13002.7 CRG90652.1 - 3.2e-53 180.3 0.1 5.3e-53 179.6 0.1 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 CRG90652.1 - 2.1e-06 27.9 0.0 1.9e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain DUF2788 PF10981.8 CRG90653.1 - 0.19 11.8 0.7 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2788) Ferritin_2 PF13668.6 CRG90654.1 - 1.1e-15 58.0 0.0 1.7e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain Amidohydro_2 PF04909.14 CRG90655.1 - 1.2e-29 104.1 0.1 1.7e-29 103.5 0.1 1.2 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 CRG90655.1 - 0.063 12.6 0.0 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 TatD related DNase PRKG1_interact PF15898.5 CRG90656.1 - 0.028 15.3 1.1 0.028 15.3 1.1 1.9 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Rootletin PF15035.6 CRG90656.1 - 0.069 13.2 0.9 0.13 12.3 0.9 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion GreA_GreB_N PF03449.15 CRG90656.1 - 0.12 12.5 0.7 0.29 11.3 0.7 1.6 1 0 0 1 1 1 0 Transcription elongation factor, N-terminal Sugar_transport PF06800.12 CRG90656.1 - 0.15 11.4 0.1 0.28 10.5 0.1 1.3 1 0 0 1 1 1 0 Sugar transport protein Tropomyosin_1 PF12718.7 CRG90656.1 - 0.22 11.7 1.9 0.18 11.9 0.3 1.6 2 0 0 2 2 2 0 Tropomyosin like DASH_Spc19 PF08287.11 CRG90656.1 - 1.2 9.0 8.6 0.2 11.5 4.2 1.9 2 1 0 2 2 2 0 Spc19 CLZ PF16526.5 CRG90656.1 - 1.6 9.1 3.8 1.5 9.2 0.2 2.6 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PIG-L PF02585.17 CRG90657.1 - 1.7e-29 103.1 0.0 2.6e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.7 CRG90658.1 - 3.4e-22 78.5 0.0 7.3e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR_3 PF13812.6 CRG90658.1 - 5.2e-07 29.7 0.0 7.4e-05 22.8 0.0 3.0 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 CRG90658.1 - 5.8e-05 23.2 0.0 0.013 15.7 0.0 3.1 3 0 0 3 3 3 1 PPR repeat family DUF2309 PF10070.9 CRG90658.1 - 0.16 10.3 0.0 0.24 9.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) LSM PF01423.22 CRG90659.1 - 1.2e-18 66.5 0.2 1.7e-18 66.1 0.2 1.2 1 0 0 1 1 1 1 LSM domain SH3_9 PF14604.6 CRG90659.1 - 2.1 8.3 4.6 4.6 7.2 0.0 2.8 3 0 0 3 3 3 0 Variant SH3 domain GTP_EFTU PF00009.27 CRG90660.1 - 7e-20 71.4 0.0 4.1e-19 68.9 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 CRG90660.1 - 1.3e-07 31.8 1.0 1.7e-06 28.3 0.6 2.7 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 CRG90660.1 - 0.00015 22.0 0.0 0.00043 20.6 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain PduV-EutP PF10662.9 CRG90660.1 - 0.00029 20.6 0.3 3.4 7.4 0.0 3.4 2 1 1 3 3 3 2 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 CRG90660.1 - 0.0041 17.2 0.1 0.011 15.8 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG90660.1 - 0.013 15.4 0.2 3.7 7.4 0.0 2.9 2 1 0 2 2 2 0 RsgA GTPase Roc PF08477.13 CRG90660.1 - 0.048 13.9 0.1 1.3 9.2 0.1 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 CRG90660.1 - 0.081 13.0 0.1 0.36 10.9 0.1 2.0 2 0 0 2 2 2 0 Dynamin family bZIP_Maf PF03131.17 CRG90662.1 - 0.29 11.7 10.0 0.47 11.0 10.0 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor OHCU_decarbox PF09349.10 CRG90663.1 - 5.7e-37 127.6 0.0 1.1e-36 126.7 0.0 1.4 1 0 0 1 1 1 1 OHCU decarboxylase WD40 PF00400.32 CRG90663.1 - 4.3e-26 90.7 8.9 6e-06 26.9 0.3 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat SRP9-21 PF05486.12 CRG90663.1 - 2.5e-21 75.9 3.4 2.5e-21 75.9 3.4 2.3 2 0 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) ANAPC4_WD40 PF12894.7 CRG90663.1 - 0.00021 21.5 0.5 8.7 6.7 0.1 4.6 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Prot_ATP_ID_OB PF16450.5 CRG90663.1 - 0.032 14.2 0.0 0.077 13.0 0.0 1.6 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Ge1_WD40 PF16529.5 CRG90663.1 - 0.036 13.0 0.0 0.15 11.0 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Abhydrolase_6 PF12697.7 CRG90664.1 - 7.4e-18 66.0 1.6 8.5e-18 65.8 1.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family PFK PF00365.20 CRG90664.1 - 0.26 10.6 0.0 0.46 9.8 0.0 1.3 1 0 0 1 1 1 0 Phosphofructokinase TruB_N PF01509.18 CRG90665.1 - 1.3e-44 152.1 0.2 4.9e-44 150.3 0.0 2.0 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TFIIS_C PF01096.18 CRG90665.1 - 7.2e-16 57.8 1.0 7.2e-16 57.8 1.0 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) TruB_C_2 PF16198.5 CRG90665.1 - 8.6e-07 29.0 0.1 3e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 tRNA pseudouridylate synthase B C-terminal domain Baculo_LEF5_C PF11792.8 CRG90665.1 - 0.0026 17.4 0.1 0.0026 17.4 0.1 2.0 2 0 0 2 2 2 1 Baculoviridae late expression factor 5 C-terminal domain RNA_POL_M_15KD PF02150.16 CRG90665.1 - 0.016 15.0 0.5 0.016 15.0 0.5 2.9 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit DUF3797 PF12677.7 CRG90665.1 - 0.04 13.8 0.5 0.1 12.5 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) DZR PF12773.7 CRG90665.1 - 0.042 13.9 6.6 0.18 11.8 0.6 2.6 2 1 0 2 2 2 0 Double zinc ribbon Stc1 PF12898.7 CRG90665.1 - 0.072 13.6 4.0 1.1 9.9 3.2 2.6 1 1 1 2 2 2 0 Stc1 domain zf-H2C2_2 PF13465.6 CRG90665.1 - 0.62 10.6 3.3 5.9 7.5 0.0 3.2 3 0 0 3 3 3 0 Zinc-finger double domain Dicty_REP PF05086.12 CRG90665.1 - 0.79 7.6 2.1 1.2 7.1 2.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 CRG90665.1 - 1.3 7.1 6.0 1.9 6.6 6.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DNA_RNApol_7kD PF03604.13 CRG90665.1 - 1.6 8.5 6.1 13 5.6 0.4 2.7 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit TF_Zn_Ribbon PF08271.12 CRG90665.1 - 2.1 7.9 12.6 5.1 6.7 1.9 3.8 2 2 1 3 3 3 0 TFIIB zinc-binding DNMT1-RFD PF12047.8 CRG90666.1 - 0.00015 21.8 0.0 0.00051 20.1 0.0 1.9 1 0 0 1 1 1 1 Cytosine specific DNA methyltransferase replication foci domain Ten1 PF12658.7 CRG90666.1 - 0.056 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Telomere capping, CST complex subunit hnRNP_Q_AcD PF18360.1 CRG90666.1 - 0.12 12.4 0.0 4.1 7.4 0.0 2.9 3 1 0 3 3 3 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain PGA2 PF07543.12 CRG90666.1 - 1.8 8.5 9.3 4.3 7.3 9.3 1.6 1 0 0 1 1 1 0 Protein trafficking PGA2 Ebp2 PF05890.12 CRG90667.1 - 7.9e-91 304.3 15.4 7.9e-91 304.3 15.4 2.0 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 HSBP1 PF06825.12 CRG90668.1 - 8.2e-20 70.4 0.5 1e-19 70.1 0.5 1.1 1 0 0 1 1 1 1 Heat shock factor binding protein 1 Baculo_PEP_C PF04513.12 CRG90668.1 - 0.00067 19.7 0.1 0.00086 19.4 0.1 1.1 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Matrilin_ccoil PF10393.9 CRG90668.1 - 0.0041 16.9 0.3 0.033 14.0 0.3 2.1 1 1 0 1 1 1 1 Trimeric coiled-coil oligomerisation domain of matrilin NPV_P10 PF05531.12 CRG90668.1 - 0.0049 17.3 0.2 0.0075 16.7 0.2 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus P10 protein BORCS6 PF10157.9 CRG90668.1 - 0.015 15.5 0.1 0.019 15.2 0.1 1.3 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Tup_N PF08581.10 CRG90668.1 - 0.017 15.4 0.1 0.028 14.7 0.1 1.3 1 0 0 1 1 1 0 Tup N-terminal CLZ PF16526.5 CRG90668.1 - 0.028 14.8 0.1 0.036 14.4 0.1 1.3 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MtrG PF04210.13 CRG90668.1 - 0.2 11.5 0.2 1.2 9.1 0.1 1.9 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Thioredoxin PF00085.20 CRG90669.1 - 4.7e-61 203.2 0.3 1.4e-30 105.3 0.0 2.5 3 0 0 3 3 3 2 Thioredoxin ERp29 PF07749.12 CRG90669.1 - 4.2e-24 85.3 0.4 8e-24 84.4 0.4 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 CRG90669.1 - 1.2e-19 70.7 1.1 6.9e-09 36.1 0.0 3.0 3 1 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 CRG90669.1 - 2.7e-14 53.2 0.0 3.5e-07 29.9 0.0 2.2 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 CRG90669.1 - 5.8e-11 42.4 0.0 2.1e-05 24.6 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 CRG90669.1 - 2.3e-10 40.6 0.7 0.0028 17.9 0.0 4.2 3 2 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 CRG90669.1 - 2.4e-10 40.4 0.4 0.00041 20.3 0.0 2.6 3 0 0 3 3 3 2 AhpC/TSA family ERp29_N PF07912.13 CRG90669.1 - 2.5e-06 27.7 0.0 0.017 15.2 0.0 2.4 2 0 0 2 2 2 2 ERp29, N-terminal domain Redoxin PF08534.10 CRG90669.1 - 1.3e-05 25.0 0.1 0.18 11.5 0.0 2.4 2 0 0 2 2 2 2 Redoxin TraF PF13728.6 CRG90669.1 - 0.00011 22.1 0.0 0.3 10.9 0.0 2.3 2 0 0 2 2 2 2 F plasmid transfer operon protein HyaE PF07449.11 CRG90669.1 - 0.00098 19.1 0.0 0.33 10.9 0.0 2.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 CRG90669.1 - 0.0012 19.0 0.4 1.7 8.9 0.0 2.8 2 1 0 2 2 2 2 Glutaredoxin Thioredoxin_9 PF14595.6 CRG90669.1 - 0.0021 17.8 0.1 1.7 8.4 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_4 PF13462.6 CRG90669.1 - 0.0041 17.3 0.8 2.3 8.4 0.0 2.9 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_5 PF13743.6 CRG90669.1 - 0.066 12.9 0.4 8.9 5.9 0.0 3.3 2 2 2 4 4 4 0 Thioredoxin CCDC32 PF14989.6 CRG90669.1 - 0.092 12.7 0.4 0.15 12.0 0.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing 32 DUF836 PF05768.14 CRG90669.1 - 0.11 13.0 0.0 2.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Glutaredoxin-like domain (DUF836) MKT1_C PF12246.8 CRG90670.1 - 7.8e-75 251.2 0.0 1.6e-74 250.1 0.0 1.5 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 CRG90670.1 - 1.4e-31 108.7 0.0 3.7e-31 107.3 0.0 1.8 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 CRG90670.1 - 0.0001 22.7 0.0 0.00029 21.3 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 CRG90670.1 - 0.00047 20.4 0.0 0.00099 19.4 0.0 1.5 1 0 0 1 1 1 1 XPG I-region Patatin PF01734.22 CRG90670.1 - 0.15 12.3 0.0 0.79 9.9 0.0 2.0 2 0 0 2 2 2 0 Patatin-like phospholipase DIOX_N PF14226.6 CRG90671.1 - 3.1e-21 76.3 0.0 5.5e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG90671.1 - 3.2e-12 46.8 0.0 7.3e-12 45.7 0.0 1.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-MYND PF01753.18 CRG90672.1 - 6.2e-08 32.6 20.7 1.6e-07 31.3 20.7 1.8 1 0 0 1 1 1 1 MYND finger SelP_N PF04592.14 CRG90672.1 - 0.2 11.0 12.5 0.43 10.0 12.5 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region adh_short PF00106.25 CRG90673.1 - 2.3e-11 43.5 0.0 3.2e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG90673.1 - 0.00083 19.3 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 KR domain WD40 PF00400.32 CRG90675.1 - 3.1e-39 132.2 19.6 1.3e-05 25.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90675.1 - 9.4e-16 57.9 0.0 0.00035 20.8 0.1 5.2 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG90675.1 - 7.2e-05 22.7 0.0 0.15 11.9 0.0 2.8 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CRG90675.1 - 0.0027 17.1 0.0 0.077 12.3 0.0 2.8 2 1 1 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 CRG90675.1 - 0.046 12.7 0.2 21 4.0 0.0 3.6 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Phosducin PF02114.16 CRG90678.1 - 3e-11 42.8 0.7 2.1e-10 40.0 0.1 2.4 1 1 1 2 2 2 1 Phosducin EF-1_beta_acid PF10587.9 CRG90678.1 - 0.32 11.5 2.7 1 9.9 2.7 1.9 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region YEATS PF03366.16 CRG90679.1 - 1.2e-19 70.0 0.0 3.3e-19 68.6 0.0 1.7 2 0 0 2 2 2 1 YEATS family BET PF17035.5 CRG90679.1 - 5.4e-07 29.7 0.3 1e-06 28.8 0.3 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Peptidase_S64 PF08192.11 CRG90679.1 - 0.044 12.3 1.1 0.059 11.9 1.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 AhpC-TSA_2 PF13911.6 CRG90679.1 - 0.074 13.2 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme Ran_BP1 PF00638.18 CRG90680.1 - 7.7e-50 168.2 2.0 7.7e-50 168.2 2.0 1.7 2 0 0 2 2 2 1 RanBP1 domain WH1 PF00568.23 CRG90680.1 - 6.3e-05 22.9 0.5 0.00041 20.3 0.5 2.0 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 CRG90680.1 - 0.001 19.3 0.1 0.0015 18.8 0.1 1.2 1 0 0 1 1 1 1 VID27 PH-like domain Esterase_phd PF10503.9 CRG90681.1 - 5.3e-21 75.1 0.1 8.8e-21 74.4 0.1 1.3 1 0 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CRG90681.1 - 1.7e-07 30.9 0.7 3.2e-07 30.0 0.7 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 CRG90681.1 - 0.053 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 CRG90681.1 - 0.068 12.8 0.1 0.23 11.1 0.2 1.8 2 0 0 2 2 2 0 Putative esterase Peptidase_C2 PF00648.21 CRG90682.1 - 2.9e-65 220.2 1.6 3.5e-44 151.0 0.4 2.3 2 0 0 2 2 2 2 Calpain family cysteine protease Calpain_III PF01067.22 CRG90682.1 - 0.092 13.0 0.7 2.5 8.4 0.0 3.2 4 0 0 4 4 4 0 Calpain large subunit, domain III IRK_N PF08466.10 CRG90682.1 - 6 7.1 6.2 1.1e+02 3.1 6.2 2.7 1 1 0 1 1 1 0 Inward rectifier potassium channel N-terminal Gpr1_Fun34_YaaH PF01184.19 CRG90683.1 - 6.8e-81 270.8 16.4 7.9e-81 270.6 16.4 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Glyco_hydro_43 PF04616.14 CRG90685.1 - 8.1e-53 179.6 3.2 9.4e-53 179.4 3.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Abhydrolase_3 PF07859.13 CRG90686.1 - 4.1e-05 23.5 0.0 0.0003 20.7 0.0 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 CRG90686.1 - 0.014 15.0 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) PGM_PMM_III PF02880.16 CRG90686.1 - 0.049 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Abhydrolase_1 PF00561.20 CRG90686.1 - 0.1 12.2 0.0 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG90686.1 - 0.12 11.9 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Pkinase PF00069.25 CRG90687.1 - 9.1e-72 241.6 0.0 1.3e-71 241.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG90687.1 - 2.3e-31 109.0 0.0 2.9e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG90687.1 - 0.00018 21.0 0.0 0.00034 20.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 CRG90687.1 - 0.00074 18.6 0.0 0.012 14.5 0.0 2.0 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 CRG90687.1 - 0.0041 17.1 0.0 0.0073 16.3 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 CRG90687.1 - 0.012 14.7 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 CRG90687.1 - 0.13 11.6 0.1 0.3 10.4 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_31 PF01055.26 CRG90688.1 - 2.7e-76 257.5 0.0 1.6e-55 189.1 0.0 3.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG90688.1 - 1.2e-13 51.3 0.0 2.3e-13 50.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG90688.1 - 0.022 15.1 0.6 0.022 15.1 0.6 2.2 3 0 0 3 3 3 0 Galactose mutarotase-like 2OG-FeII_Oxy_2 PF13532.6 CRG90689.1 - 6e-29 101.6 0.0 1.2e-28 100.6 0.0 1.4 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF4600 PF15372.6 CRG90690.1 - 0.1 13.0 1.9 0.19 12.2 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4600) zf-C2H2_4 PF13894.6 CRG90690.1 - 1.3 10.1 3.4 0.73 10.8 0.7 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Zn_clus PF00172.18 CRG90691.1 - 6.3e-08 32.6 8.8 9.8e-08 32.0 8.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG90692.1 - 6e-27 94.5 34.4 8.5e-27 94.0 34.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3377 PF11857.8 CRG90692.1 - 0.83 9.6 3.8 20 5.2 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) Epimerase PF01370.21 CRG90693.1 - 3.4e-07 30.0 0.3 2.6e-06 27.1 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG90693.1 - 1.5e-05 25.0 0.0 2e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Shikimate_DH PF01488.20 CRG90693.1 - 0.0033 17.5 0.0 0.005 16.9 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_2 PF03446.15 CRG90693.1 - 0.0072 16.5 0.0 0.011 15.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3Beta_HSD PF01073.19 CRG90693.1 - 0.017 14.1 0.0 0.29 10.1 0.0 2.0 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG90693.1 - 0.018 14.2 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein ApbA PF02558.16 CRG90693.1 - 0.027 14.1 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 CRG90693.1 - 0.047 14.3 0.1 0.098 13.2 0.1 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 CRG90693.1 - 0.059 12.9 0.1 0.09 12.3 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.15 CRG90693.1 - 0.065 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Acyl-CoA_dh_1 PF00441.24 CRG90694.1 - 1.9e-31 109.3 1.4 3.5e-31 108.4 1.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CRG90694.1 - 1.7e-22 79.4 0.0 3.2e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CRG90694.1 - 3.2e-20 72.9 0.1 7.1e-20 71.8 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CRG90694.1 - 2.2e-12 47.4 1.3 2.2e-12 47.4 1.3 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain CoA_transf_3 PF02515.17 CRG90695.1 - 1.4e-109 366.6 0.0 1.6e-109 366.4 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III ABC2_membrane PF01061.24 CRG90696.1 - 2.1e-83 278.9 56.7 8.8e-48 162.5 23.0 2.8 4 0 0 4 4 3 2 ABC-2 type transporter PDR_CDR PF06422.12 CRG90696.1 - 4.4e-37 125.9 3.4 7.1e-29 99.6 0.0 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 CRG90696.1 - 3.4e-36 124.8 0.0 6.1e-17 62.4 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 CRG90696.1 - 2.9e-12 46.4 41.5 8.5e-07 28.4 18.6 2.4 2 0 0 2 2 2 2 ABC-2 family transporter protein ABC_trans_N PF14510.6 CRG90696.1 - 6.3e-12 45.9 2.4 6.5e-12 45.9 0.1 2.3 2 0 0 2 2 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 CRG90696.1 - 5.1e-06 27.0 0.2 0.0011 19.4 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CRG90696.1 - 2.2e-05 24.4 0.1 0.00012 22.0 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 CRG90696.1 - 7.3e-05 22.7 0.0 0.15 11.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 CRG90696.1 - 0.00026 21.2 0.1 0.036 14.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CRG90696.1 - 0.0012 18.5 0.2 0.5 10.2 0.0 3.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CRG90696.1 - 0.0017 18.7 0.4 1.7 8.9 0.1 3.0 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 CRG90696.1 - 0.0029 18.2 0.5 0.089 13.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 CRG90696.1 - 0.0032 17.1 0.1 0.026 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 CRG90696.1 - 0.0051 17.3 0.1 0.25 11.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 CRG90696.1 - 0.0096 15.5 0.1 0.31 10.6 0.1 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 CRG90696.1 - 0.016 15.1 0.1 0.68 9.8 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 CRG90696.1 - 0.018 14.7 0.1 0.24 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CRG90696.1 - 0.019 15.1 0.2 2.2 8.4 0.1 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 CRG90696.1 - 0.022 15.0 1.0 0.068 13.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain dNK PF01712.19 CRG90696.1 - 0.098 12.5 0.0 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Deoxynucleoside kinase DnaB_C PF03796.15 CRG90696.1 - 0.11 11.8 0.0 7 5.9 0.0 2.3 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain FtsK_SpoIIIE PF01580.18 CRG90696.1 - 0.12 11.7 0.2 10 5.4 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family GET2 PF08690.10 CRG90696.1 - 0.49 10.0 9.2 2.8 7.5 3.1 3.1 3 0 0 3 3 3 0 GET complex subunit GET2 AAA_23 PF13476.6 CRG90696.1 - 0.68 10.4 4.2 2.8 8.4 0.0 3.0 3 0 0 3 3 2 0 AAA domain PsbN PF02468.15 CRG90697.1 - 0.89 9.5 2.8 1.8 8.5 2.8 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre N protein (psbN) Ribosomal_L27_C PF18471.1 CRG90698.1 - 0.0042 16.5 0.1 0.0053 16.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain TLP-20 PF06088.11 CRG90698.1 - 0.056 13.3 0.4 0.056 13.3 0.4 1.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Mak16 PF04874.14 CRG90698.1 - 0.76 10.4 16.5 0.23 12.1 12.5 1.9 2 0 0 2 2 2 0 Mak16 protein C-terminal region MFS_1 PF07690.16 CRG90699.1 - 1.7e-33 116.0 32.2 1.7e-33 116.0 32.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily RRM_1 PF00076.22 CRG90699.1 - 6.9e-18 64.2 0.1 1.3e-17 63.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sugar_tr PF00083.24 CRG90699.1 - 2.6e-07 29.9 14.1 2.6e-07 29.9 14.1 2.8 3 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CRG90699.1 - 1.6e-05 23.6 5.5 2.5e-05 22.9 5.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) adh_short_C2 PF13561.6 CRG90700.1 - 1.7e-56 191.4 1.6 2e-56 191.2 1.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG90700.1 - 7.8e-46 156.0 1.8 1e-45 155.6 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase 3HCDH_N PF02737.18 CRG90700.1 - 0.15 11.9 0.6 0.26 11.1 0.2 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Abhydrolase_3 PF07859.13 CRG90701.1 - 1.7e-42 145.7 0.0 2.3e-42 145.3 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 CRG90701.1 - 1.1e-06 27.8 0.1 5.1e-06 25.6 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family ABM PF03992.16 CRG90702.1 - 5.8e-08 32.7 1.5 0.0013 18.8 0.2 2.5 2 1 0 2 2 2 2 Antibiotic biosynthesis monooxygenase Cyclase PF04199.13 CRG90703.1 - 1.8e-13 50.9 0.0 2.3e-13 50.6 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase T3SS_ExsE PF18286.1 CRG90703.1 - 0.12 12.3 0.7 0.46 10.5 0.1 2.2 2 0 0 2 2 2 0 Type III secretion system ExsE FMO-like PF00743.19 CRG90705.1 - 8.3e-19 67.4 3.1 1.7e-17 63.1 1.6 2.6 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG90705.1 - 2.9e-07 30.6 0.0 7.2e-07 29.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CRG90705.1 - 0.00012 21.4 0.1 0.0041 16.3 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG90705.1 - 0.00019 20.8 0.3 0.0028 17.0 0.4 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90705.1 - 0.0066 16.5 0.0 0.26 11.3 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CRG90705.1 - 0.0072 15.6 0.0 3.7 6.7 0.0 3.1 4 0 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG90705.1 - 0.13 12.8 0.0 0.5 11.0 0.0 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 CRG90706.1 - 8e-17 61.1 0.1 4.6e-16 58.6 0.1 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Forkhead_N PF08430.12 CRG90706.1 - 7.2 7.2 8.0 0.73 10.5 2.2 2.2 2 0 0 2 2 2 0 Forkhead N-terminal region 6PGD PF00393.19 CRG90707.1 - 6.8e-127 422.8 0.0 9.7e-127 422.3 0.0 1.2 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CRG90707.1 - 8.4e-50 169.0 0.0 2.4e-49 167.6 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AD PF09793.9 CRG90707.1 - 9.2e-28 96.2 0.0 1.9e-27 95.2 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain Glyco_hydro_15 PF00723.21 CRG90708.1 - 3e-47 161.4 0.0 3.1e-45 154.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 TPT PF03151.16 CRG90709.1 - 1.6e-20 73.7 16.9 2.2e-20 73.2 16.9 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 CRG90709.1 - 1.5e-07 31.7 30.5 0.00062 19.9 10.8 2.2 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 CRG90709.1 - 0.059 12.6 18.0 0.22 10.7 17.8 1.9 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport CDC45 PF02724.14 CRG90709.1 - 0.17 10.2 1.3 0.22 9.8 1.3 1.1 1 0 0 1 1 1 0 CDC45-like protein REV PF00424.18 CRG90709.1 - 0.38 10.8 3.9 0.3 11.1 1.4 2.0 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) PBP1_TM PF14812.6 CRG90709.1 - 3.1 8.2 10.3 6.9 7.1 10.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AP_endonuc_2 PF01261.24 CRG90710.1 - 1.1e-28 100.1 0.0 2e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Mad3_BUB1_I PF08311.12 CRG90711.1 - 7.7e-45 151.9 0.2 1.6e-44 150.8 0.2 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 CRG90711.1 - 7.8e-10 38.6 0.0 7.4e-09 35.3 0.0 2.4 2 1 0 2 2 2 1 Protein kinase domain Mad3_BUB1_II PF08171.11 CRG90711.1 - 0.0033 17.6 0.0 0.024 14.8 0.0 2.4 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Mad3_BUB1_I_2 PF17014.5 CRG90711.1 - 0.0056 16.8 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Pkinase_Tyr PF07714.17 CRG90711.1 - 0.022 14.1 0.0 0.037 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase NOA36 PF06524.12 CRG90711.1 - 4.1 6.6 8.6 9.8 5.4 8.6 1.6 1 0 0 1 1 1 0 NOA36 protein CN_hydrolase PF00795.22 CRG90713.1 - 1.2e-43 149.3 0.0 1.5e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Fungal_trans_2 PF11951.8 CRG90714.1 - 4.6e-34 117.9 10.8 6.1e-30 104.3 4.6 2.1 1 1 1 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90714.1 - 1.2e-09 38.1 6.0 2.4e-09 37.2 6.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyoxalase_4 PF13669.6 CRG90715.1 - 2.9e-19 69.3 0.0 5.3e-19 68.5 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Polysacc_deac_1 PF01522.21 CRG90716.1 - 2e-19 69.7 0.0 3.5e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 CRG90716.1 - 3.4e-06 26.9 0.1 1e-05 25.3 0.1 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) DUF2194 PF09960.9 CRG90716.1 - 0.0011 17.4 0.1 0.0017 16.8 0.1 1.3 1 1 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2194) DUF1989 PF09347.10 CRG90717.1 - 2.8e-50 170.2 0.0 3.5e-50 169.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) AA_permease_2 PF13520.6 CRG90718.1 - 1.8e-46 158.9 52.5 2.2e-46 158.6 52.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG90718.1 - 3e-20 72.3 46.9 4.1e-20 71.8 46.9 1.1 1 0 0 1 1 1 1 Amino acid permease MOSC PF03473.17 CRG90719.1 - 3.2e-30 104.8 0.0 9.8e-30 103.3 0.0 1.8 2 0 0 2 2 2 1 MOSC domain MOSC_N PF03476.16 CRG90719.1 - 2.8e-23 82.1 0.0 5e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Peptidase_C15 PF01470.17 CRG90719.1 - 3.2e-12 47.0 0.0 0.00023 21.4 0.0 3.1 2 1 0 2 2 2 2 Pyroglutamyl peptidase DNA_pol_phi PF04931.13 CRG90720.1 - 3.1e-246 819.3 18.4 3.1e-246 819.3 18.4 1.5 2 0 0 2 2 2 1 DNA polymerase phi SEO_N PF14576.6 CRG90720.1 - 0.13 11.4 0.0 0.13 11.4 0.0 2.2 3 0 0 3 3 3 0 Sieve element occlusion N-terminus SDA1 PF05285.12 CRG90720.1 - 0.15 11.4 26.0 0.021 14.3 21.6 1.7 2 0 0 2 2 2 0 SDA1 CTD_bind PF04818.13 CRG90720.1 - 1.4 9.8 3.6 6.8 7.6 0.0 4.0 5 0 0 5 5 5 0 RNA polymerase II-binding domain. Iso_dh PF00180.20 CRG90721.1 - 3.5e-86 289.5 0.0 4.2e-86 289.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Rhodanese PF00581.20 CRG90722.1 - 6.2e-13 49.2 0.0 1.4e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain SLD5_C PF16922.5 CRG90723.1 - 6.8e-11 42.2 1.5 1.1e-10 41.6 1.5 1.3 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 CRG90723.1 - 1.5e-07 31.9 0.1 2.2e-07 31.3 0.1 1.4 1 0 0 1 1 1 1 GINS complex protein UBM PF14377.6 CRG90723.1 - 0.056 12.9 0.1 0.18 11.3 0.1 1.9 1 0 0 1 1 1 0 Ubiquitin binding region Phage_head_fibr PF11133.8 CRG90723.1 - 0.068 12.6 0.2 0.1 12.0 0.2 1.2 1 0 0 1 1 1 0 Head fiber protein PAP1 PF08601.10 CRG90723.1 - 0.071 12.8 3.7 0.084 12.6 3.7 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Cullin PF00888.22 CRG90724.1 - 9.9e-201 668.5 5.0 1.3e-200 668.2 5.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 CRG90724.1 - 1.6e-25 88.9 2.1 3.3e-25 87.9 0.2 2.4 2 0 0 2 2 2 1 Cullin protein neddylation domain PP_kinase_N PF13089.6 CRG90724.1 - 0.089 13.1 0.1 0.34 11.3 0.1 2.0 1 0 0 1 1 1 0 Polyphosphate kinase N-terminal domain zf-DNL PF05180.12 CRG90725.1 - 3.4e-29 100.6 0.7 4.9e-29 100.1 0.7 1.2 1 0 0 1 1 1 1 DNL zinc finger TFIIS_C PF01096.18 CRG90725.1 - 0.045 13.6 1.4 4.7 7.1 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 CRG90725.1 - 0.093 12.9 0.6 0.17 12.0 0.6 1.5 1 0 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 CRG90725.1 - 0.1 12.6 0.5 0.16 12.0 0.5 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-CSL PF05207.13 CRG90725.1 - 0.13 12.0 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 CSL zinc finger DRIM PF07539.12 CRG90726.1 - 1.1e-183 612.0 0.7 1.1e-183 612.0 0.7 3.6 4 0 0 4 4 4 1 Down-regulated in metastasis HEAT PF02985.22 CRG90726.1 - 0.0001 22.3 1.1 34 5.1 0.0 7.1 8 0 0 8 8 8 1 HEAT repeat HEAT_2 PF13646.6 CRG90726.1 - 0.14 12.6 3.1 1.1e+02 3.3 0.0 5.5 5 0 0 5 5 5 0 HEAT repeats EntA_Immun PF08951.10 CRG90726.1 - 3.7 8.0 6.6 1.3 9.5 0.5 3.6 4 0 0 4 4 4 0 Enterocin A Immunity CwfJ_C_1 PF04677.15 CRG90727.1 - 2.6e-23 82.2 0.0 4.3e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 CRG90727.1 - 6.2e-16 59.1 0.2 1.2e-15 58.2 0.2 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Corona_S2 PF01601.16 CRG90728.1 - 6.5 5.1 14.8 9.1 4.6 14.8 1.0 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein RCR PF12273.8 CRG90729.1 - 8.1e-24 84.6 12.0 1.1e-23 84.1 12.0 1.2 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red SARAF PF06682.12 CRG90729.1 - 0.012 15.3 0.2 0.013 15.1 0.2 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Adeno_E3_CR2 PF02439.15 CRG90729.1 - 0.2 11.4 0.9 0.31 10.8 0.9 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Abhydrolase_1 PF00561.20 CRG90730.1 - 4.4e-16 59.3 0.0 6.1e-16 58.8 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG90730.1 - 4.3e-15 56.9 3.4 5.2e-15 56.6 3.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG90730.1 - 7.2e-08 32.0 0.0 1.1e-07 31.4 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CRG90730.1 - 0.04 14.0 0.0 0.068 13.3 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Ndr PF03096.14 CRG90730.1 - 0.06 12.0 0.0 1.8 7.2 0.0 2.1 2 0 0 2 2 2 0 Ndr family LIDHydrolase PF10230.9 CRG90730.1 - 0.16 11.5 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Arf PF00025.21 CRG90731.1 - 6.5e-26 90.8 0.1 8.5e-25 87.2 0.1 1.9 1 1 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 CRG90731.1 - 3.8e-09 36.4 0.0 0.0016 18.1 0.1 2.1 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 CRG90731.1 - 7.9e-06 25.9 0.1 1.3e-05 25.3 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 CRG90731.1 - 0.00027 21.1 0.1 0.0012 19.0 0.1 1.9 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1_Xtn PF16897.5 CRG90731.1 - 0.0046 17.0 0.0 0.0067 16.4 0.0 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain RsgA_GTPase PF03193.16 CRG90731.1 - 0.008 16.1 0.1 2.1 8.2 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 CRG90731.1 - 0.02 14.3 0.0 0.22 11.0 0.0 2.0 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 CRG90731.1 - 0.027 14.6 0.2 0.045 13.8 0.1 1.3 1 1 0 1 1 1 0 Dynamin family FeoB_N PF02421.18 CRG90731.1 - 0.15 11.5 0.1 0.39 10.2 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B DUF1979 PF09322.10 CRG90731.1 - 0.32 10.9 1.0 13 5.7 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1979) RNA_pol_Rpb2_6 PF00562.28 CRG90732.1 - 1.5e-116 389.7 0.0 2e-116 389.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CRG90732.1 - 1.9e-33 115.7 0.0 3e-33 115.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 CRG90732.1 - 4.5e-27 94.0 0.0 1.1e-26 92.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 CRG90732.1 - 1.4e-26 92.3 0.0 2.9e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 CRG90732.1 - 9.5e-23 80.8 0.0 1.8e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 CRG90732.1 - 2.1e-14 53.7 0.0 2.1e-13 50.5 0.1 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 BA14K PF07886.11 CRG90732.1 - 0.15 12.0 0.5 0.61 10.0 0.1 2.3 2 0 0 2 2 2 0 BA14K-like protein Pil1 PF13805.6 CRG90733.1 - 3.2e-94 315.3 5.1 3.2e-94 315.3 5.1 1.7 2 0 0 2 2 2 1 Eisosome component PIL1 Proteasome PF00227.26 CRG90733.1 - 1.5e-41 142.0 0.4 4.4e-32 111.1 0.1 2.3 2 0 0 2 2 2 2 Proteasome subunit MFS_1 PF07690.16 CRG90734.1 - 2.2e-31 109.1 29.7 2.2e-31 109.1 29.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG90734.1 - 0.0014 17.6 2.5 0.0029 16.5 2.5 1.5 1 1 0 1 1 1 1 MFS_1 like family SWI-SNF_Ssr4 PF08549.10 CRG90735.1 - 2.9e-244 813.0 24.5 1.8e-242 807.1 24.5 2.7 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Pkinase_C PF00433.24 CRG90735.1 - 0.011 16.5 1.0 0.054 14.2 1.0 2.3 1 0 0 1 1 1 0 Protein kinase C terminal domain Uds1 PF15456.6 CRG90735.1 - 0.1 12.8 2.1 0.2 11.8 2.1 1.5 1 0 0 1 1 1 0 Up-regulated During Septation Methyltransf_23 PF13489.6 CRG90736.1 - 1.9e-18 66.9 0.0 3e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90736.1 - 2.1e-08 34.7 0.0 8.9e-08 32.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG90736.1 - 1.2e-07 32.4 0.0 2.9e-06 27.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90736.1 - 1.1e-06 28.6 0.0 0.033 14.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90736.1 - 9.6e-05 23.0 0.0 0.0002 22.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG90736.1 - 0.00083 18.9 0.0 0.0022 17.5 0.0 1.6 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 CRG90736.1 - 0.15 11.4 0.0 0.71 9.2 0.0 2.1 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 CRG90737.1 - 3.5e-16 59.1 0.0 6.5e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain HTH_IclR PF09339.10 CRG90737.1 - 0.13 12.1 0.2 0.35 10.7 0.0 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain Dimerisation PF08100.11 CRG90737.1 - 0.14 12.2 0.1 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 Dimerisation domain Ppx-GppA PF02541.16 CRG90739.1 - 6.4e-46 157.1 0.0 9.6e-46 156.5 0.0 1.2 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DUF3168 PF11367.8 CRG90739.1 - 0.018 15.2 0.3 3.2 8.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3168) GDA1_CD39 PF01150.17 CRG90739.1 - 0.18 10.4 0.0 0.35 9.5 0.0 1.4 1 0 0 1 1 1 0 GDA1/CD39 (nucleoside phosphatase) family Thi4 PF01946.17 CRG90740.1 - 1.2e-111 371.7 0.0 1.4e-111 371.4 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CRG90740.1 - 6.6e-07 29.2 1.5 3.7e-06 26.8 1.4 1.9 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG90740.1 - 8.3e-05 22.7 0.9 0.00029 21.0 0.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG90740.1 - 0.00087 18.4 0.6 0.0019 17.3 0.5 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG90740.1 - 0.0018 17.6 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90740.1 - 0.0051 16.8 1.2 0.0085 16.1 0.1 2.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CRG90740.1 - 0.0074 15.4 0.8 0.17 10.9 0.6 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 CRG90740.1 - 0.037 13.3 0.2 0.39 9.9 0.2 2.1 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG90740.1 - 0.082 12.1 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 CRG90740.1 - 0.2 10.5 0.2 0.28 10.0 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 CRG90740.1 - 0.31 10.3 0.9 0.4 10.0 0.9 1.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase Exo_endo_phos PF03372.23 CRG90741.1 - 1.2e-12 47.9 0.0 1.7e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 CRG90742.1 - 3.4e-54 179.6 16.5 2.8e-11 43.8 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG90742.1 - 3e-17 62.7 0.0 0.00037 20.7 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG90742.1 - 1.3e-12 47.2 4.9 0.056 12.1 0.0 5.2 2 1 2 5 5 5 5 Nucleoporin Nup120/160 eIF2A PF08662.11 CRG90742.1 - 5e-08 33.1 0.0 0.0053 16.7 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CRG90742.1 - 1.4e-05 24.6 0.0 0.0019 17.6 0.0 2.5 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 CRG90742.1 - 8.4e-05 21.7 0.3 3.5 6.5 0.0 4.1 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 CRG90742.1 - 0.0027 16.9 0.2 0.57 9.2 0.0 3.0 1 1 2 3 3 3 1 Protein of unknown function (DUF1513) VID27 PF08553.10 CRG90742.1 - 0.0096 15.0 0.0 0.073 12.1 0.0 2.4 2 1 1 3 3 3 1 VID27 C-terminal WD40-like domain Frtz PF11768.8 CRG90742.1 - 0.034 12.5 0.0 0.18 10.0 0.0 2.0 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 CRG90742.1 - 0.11 11.6 0.0 9.2 5.2 0.0 2.2 1 1 1 2 2 2 0 Coatomer WD associated region Glyco_hydro_cc PF11790.8 CRG90743.1 - 1.5e-56 191.6 3.2 1.9e-56 191.3 3.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core RED_N PF07808.13 CRG90744.1 - 5.3e-11 42.6 8.6 5.3e-11 42.6 8.6 1.9 2 0 0 2 2 2 1 RED-like protein N-terminal region GvpG PF05120.12 CRG90744.1 - 0.14 12.2 2.0 0.61 10.1 0.3 2.6 2 0 0 2 2 2 0 Gas vesicle protein G Tom22 PF04281.13 CRG90744.1 - 0.3 10.9 0.1 0.3 10.9 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial import receptor subunit Tom22 zf-UBR PF02207.20 CRG90745.1 - 4.7e-17 61.9 16.6 1.4e-16 60.4 16.6 1.9 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 CRG90745.1 - 0.0039 16.9 0.0 0.01 15.6 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS SDA1 PF05285.12 CRG90745.1 - 0.037 13.5 4.3 0.078 12.4 4.3 1.4 1 0 0 1 1 1 0 SDA1 UCR_UQCRX_QCR9 PF05365.12 CRG90746.1 - 5.4e-26 90.3 1.9 6.8e-26 90.0 1.9 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Mago-bind PF09282.10 CRG90747.1 - 5.9e-12 45.2 3.4 1.1e-11 44.4 3.4 1.5 1 0 0 1 1 1 1 Mago binding Nucleo_P87 PF07267.11 CRG90747.1 - 0.13 11.1 4.9 0.14 11.0 4.9 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2201_N PF13203.6 CRG90747.1 - 0.42 10.2 8.4 0.53 9.8 8.4 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain RR_TM4-6 PF06459.12 CRG90747.1 - 3.4 7.4 10.7 4.5 7.0 10.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Amino_oxidase PF01593.24 CRG90748.1 - 1.5e-29 103.6 0.0 2.5e-29 102.9 0.0 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CRG90748.1 - 5.4e-14 52.2 0.6 1.1e-13 51.2 0.0 1.8 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG90748.1 - 5.5e-06 26.2 0.0 1.2e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG90748.1 - 0.00035 20.6 0.1 0.0026 17.8 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 CRG90748.1 - 0.002 18.7 0.1 0.48 11.0 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG90748.1 - 0.015 14.5 0.0 0.031 13.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 CRG90748.1 - 0.022 14.0 0.1 0.055 12.7 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG90748.1 - 0.039 13.3 0.1 0.083 12.2 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase MCRA PF06100.11 CRG90748.1 - 0.089 11.6 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 MCRA family FAD_binding_2 PF00890.24 CRG90748.1 - 0.14 11.3 0.0 0.24 10.4 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 CRG90748.1 - 0.15 10.7 0.1 0.37 9.4 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein zf-CCCH_2 PF14608.6 CRG90749.1 - 7.5e-15 54.8 55.4 2.2e-06 27.9 10.3 5.4 5 0 0 5 5 5 4 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 CRG90749.1 - 0.035 14.4 0.0 0.061 13.6 0.0 1.4 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) p450 PF00067.22 CRG90750.1 - 5.6e-54 183.6 0.0 1.5e-53 182.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 Methyltransf_23 PF13489.6 CRG90751.1 - 4.5e-15 55.9 0.0 7.6e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90751.1 - 1.1e-07 32.5 0.4 1.4e-06 28.9 0.2 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90751.1 - 2.9e-07 30.4 0.1 3.5e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90751.1 - 0.00023 21.8 0.1 0.00078 20.1 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG90751.1 - 0.00029 21.5 0.3 0.0023 18.6 0.3 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG90751.1 - 0.00091 18.7 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 CRG90751.1 - 0.0012 19.0 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 CRG90751.1 - 0.015 14.8 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 CRG90751.1 - 0.035 13.4 0.0 0.12 11.7 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 CRG90751.1 - 0.046 13.0 0.0 0.083 12.2 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_16 PF10294.9 CRG90751.1 - 0.089 12.5 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase FGGY_C PF02782.16 CRG90752.1 - 2.2e-74 249.5 0.5 3.7e-74 248.7 0.5 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CRG90752.1 - 3.6e-69 233.0 0.0 4.8e-69 232.6 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CRG90752.1 - 0.054 13.0 0.1 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family MIP PF00230.20 CRG90753.1 - 1.3e-52 178.8 0.6 1.6e-52 178.5 0.6 1.0 1 0 0 1 1 1 1 Major intrinsic protein Glyco_hydro_16 PF00722.21 CRG90754.1 - 1.5e-44 151.6 2.7 2.5e-44 150.9 2.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Peptidase_S10 PF00450.22 CRG90755.1 - 1.4e-101 341.0 7.2 1.7e-101 340.7 7.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase MSC PF09402.10 CRG90756.1 - 1.7e-105 353.2 0.0 2.5e-105 352.7 0.0 1.3 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain PP2C PF00481.21 CRG90756.1 - 1.2e-52 179.1 0.0 1.9e-52 178.5 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 CRG90756.1 - 9.7e-36 121.3 57.9 1.6e-07 31.0 9.2 11.3 5 3 4 11 11 11 8 Leucine rich repeat Guanylate_cyc PF00211.20 CRG90756.1 - 6.1e-30 104.2 0.0 1.1e-29 103.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_4 PF12799.7 CRG90756.1 - 6.1e-24 83.7 64.8 0.0016 18.8 0.2 11.4 8 2 3 12 12 12 11 Leucine Rich repeats (2 copies) HeH PF12949.7 CRG90756.1 - 1.5e-16 59.8 0.2 3.4e-16 58.6 0.2 1.7 1 0 0 1 1 1 1 HeH/LEM domain LRR_9 PF14580.6 CRG90756.1 - 8e-08 32.0 17.4 0.0043 16.6 0.3 4.9 2 1 3 5 5 5 4 Leucine-rich repeat LRR_5 PF13306.6 CRG90756.1 - 3.5e-05 23.8 6.7 0.17 11.8 0.1 4.6 5 0 0 5 5 5 3 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 CRG90756.1 - 8.5 7.4 55.9 19 6.3 0.1 14.1 12 4 0 12 12 12 0 Leucine Rich Repeat Glyco_hydro_71 PF03659.14 CRG90757.1 - 3.6e-129 430.9 7.7 4.2e-129 430.6 7.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 DUF4434 PF14488.6 CRG90757.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) HECT PF00632.25 CRG90758.1 - 8.8e-79 265.2 0.0 2.4e-78 263.7 0.0 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) HEAT PF02985.22 CRG90758.1 - 8.1e-05 22.6 0.8 0.023 15.0 0.2 3.9 3 0 0 3 3 3 1 HEAT repeat Arm PF00514.23 CRG90758.1 - 0.0023 17.9 9.6 0.15 12.1 0.2 5.7 5 1 1 6 6 6 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 CRG90758.1 - 0.0041 17.6 0.1 0.053 14.0 0.1 2.9 2 0 0 2 2 2 1 HEAT-like repeat Adaptin_N PF01602.20 CRG90758.1 - 0.0041 15.7 0.1 0.0041 15.7 0.1 2.8 3 0 0 3 3 3 1 Adaptin N terminal region CLASP_N PF12348.8 CRG90758.1 - 0.051 13.1 0.1 0.4 10.2 0.0 2.3 2 0 0 2 2 2 0 CLASP N terminal CTP_transf_like PF01467.26 CRG90759.1 - 1.4e-20 74.0 0.0 1.9e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Granulin PF00396.18 CRG90760.1 - 0.00023 21.4 3.9 0.00023 21.4 3.9 2.5 2 0 0 2 2 2 2 Granulin SIS PF01380.22 CRG90761.1 - 1.4e-12 47.6 0.1 3.4e-12 46.4 0.1 1.7 1 1 0 1 1 1 1 SIS domain SIS_2 PF13580.6 CRG90761.1 - 9.8e-06 25.6 0.1 0.00021 21.3 0.1 2.3 1 1 1 2 2 2 1 SIS domain eIF-5a PF01287.20 CRG90761.1 - 0.0032 17.5 0.1 0.0066 16.5 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold HU-CCDC81_bac_2 PF18175.1 CRG90761.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.3 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 2 Ubie_methyltran PF01209.18 CRG90763.1 - 1.2e-80 270.1 0.0 1.6e-80 269.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 CRG90763.1 - 2.5e-16 60.1 0.0 1.1e-15 58.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90763.1 - 2.2e-14 53.8 0.0 7.2e-14 52.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90763.1 - 2e-12 47.2 0.0 2.7e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG90763.1 - 9.1e-10 39.2 0.0 1.7e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG90763.1 - 3.1e-07 30.4 0.0 4.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CRG90763.1 - 0.072 12.9 0.0 0.36 10.7 0.0 2.0 2 1 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_24 PF13578.6 CRG90763.1 - 0.15 13.1 0.0 0.3 12.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain p450 PF00067.22 CRG90764.1 - 3.2e-53 181.1 0.0 4.5e-53 180.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 SH3_16 PF18348.1 CRG90764.1 - 0.14 12.0 0.0 0.82 9.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial dipeptidyl-peptidase Sh3 domain Glyco_hydro_71 PF03659.14 CRG90765.1 - 1.4e-127 425.6 3.9 1.7e-127 425.4 3.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 Cupin_2 PF07883.11 CRG90766.1 - 2.8e-08 33.4 0.0 4.7e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 Cupin domain Pirin PF02678.16 CRG90767.1 - 4.3e-26 91.0 0.4 9.7e-26 89.9 0.4 1.6 1 0 0 1 1 1 1 Pirin Transferase PF02458.15 CRG90767.1 - 6.7e-10 38.2 0.0 1.6e-08 33.6 0.0 2.1 1 1 0 1 1 1 1 Transferase family Cupin_2 PF07883.11 CRG90767.1 - 6.1e-05 22.7 2.1 0.00025 20.7 0.3 2.5 2 1 0 2 2 2 1 Cupin domain FAD_binding_3 PF01494.19 CRG90768.1 - 2.8e-21 76.2 0.0 5.9e-21 75.1 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 CRG90768.1 - 9.2e-05 22.5 0.0 0.0004 20.4 0.0 2.0 1 1 0 1 1 1 1 FAD-NAD(P)-binding DAO PF01266.24 CRG90768.1 - 0.00019 21.1 0.7 0.0012 18.5 0.6 1.9 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG90768.1 - 0.00025 21.2 0.3 0.00083 19.5 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG90768.1 - 0.00039 19.8 0.1 0.0076 15.5 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 CRG90768.1 - 0.00049 19.2 0.0 0.027 13.5 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase Amino_oxidase PF01593.24 CRG90768.1 - 0.052 12.8 0.2 0.44 9.8 0.0 2.4 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 CRG90768.1 - 0.06 12.6 0.1 0.094 11.9 0.1 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CRG90768.1 - 0.078 13.6 0.4 0.078 13.6 0.4 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG90768.1 - 0.1 11.4 0.6 4.3 6.1 0.4 2.1 2 0 0 2 2 2 0 Tryptophan halogenase HI0933_like PF03486.14 CRG90768.1 - 0.11 11.2 0.1 0.17 10.5 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_2 PF00890.24 CRG90768.1 - 0.47 9.5 2.3 0.57 9.2 0.8 1.8 2 0 0 2 2 2 0 FAD binding domain Fungal_trans PF04082.18 CRG90769.1 - 8.5e-13 47.9 0.0 2e-12 46.7 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain K_channel_TID PF07941.11 CRG90771.1 - 0.59 10.6 3.6 1.7 9.1 0.8 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain TRI12 PF06609.13 CRG90772.1 - 4.9e-26 91.3 22.1 6.3e-26 90.9 22.1 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CRG90772.1 - 2.5e-23 82.6 42.7 2.5e-23 82.6 42.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG90773.1 - 9.3e-25 87.2 1.6 1.1e-24 86.9 0.1 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90773.1 - 2.4e-06 27.6 9.5 4.9e-06 26.6 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FA_hydroxylase PF04116.13 CRG90774.1 - 7e-20 71.7 17.3 7e-20 71.7 17.3 2.1 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily Tox-MPTase5 PF15641.6 CRG90774.1 - 0.038 14.0 0.1 0.064 13.3 0.1 1.4 1 0 0 1 1 1 0 Metallopeptidase toxin 5 OCD_Mu_crystall PF02423.15 CRG90775.1 - 1.6e-11 43.8 0.0 3.9e-11 42.5 0.0 1.6 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 CRG90775.1 - 7.8e-06 26.0 0.3 0.0014 18.7 0.0 2.7 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Alba PF01918.21 CRG90775.1 - 0.027 14.3 0.0 2.5 8.0 0.0 2.7 2 0 0 2 2 2 0 Alba Ribosomal_S16 PF00886.19 CRG90775.1 - 0.082 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S16 DUF3479 PF11965.8 CRG90775.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3479) Pro_dh PF01619.18 CRG90776.1 - 4.1e-63 213.7 0.1 5.3e-63 213.3 0.1 1.1 1 0 0 1 1 1 1 Proline dehydrogenase bZIP_2 PF07716.15 CRG90776.1 - 0.051 13.7 0.4 0.051 13.7 0.4 1.8 2 0 0 2 2 2 0 Basic region leucine zipper COesterase PF00135.28 CRG90777.1 - 1e-83 282.0 1.3 1.3e-83 281.6 1.3 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG90777.1 - 1.5e-07 31.5 0.9 3.9e-06 26.9 0.6 3.0 2 1 0 2 2 2 1 alpha/beta hydrolase fold MFS_1 PF07690.16 CRG90778.1 - 4.7e-30 104.7 38.2 4.7e-30 104.7 38.2 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90778.1 - 1.2e-06 27.7 17.2 1.2e-06 27.7 17.2 2.4 2 1 1 3 3 3 1 Sugar (and other) transporter BUD22 PF09073.10 CRG90779.1 - 1.5e-103 347.5 26.5 1.7e-103 347.3 26.5 1.0 1 0 0 1 1 1 1 BUD22 E1_dh PF00676.20 CRG90781.1 - 6.4e-88 294.6 0.0 8.2e-88 294.2 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Amidohydro_2 PF04909.14 CRG90781.1 - 6.8e-37 127.8 0.0 1.2e-36 127.0 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase TPP_enzyme_C PF02775.21 CRG90781.1 - 0.00031 20.6 0.1 0.0061 16.3 0.1 2.7 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain zf-RING_4 PF14570.6 CRG90782.1 - 8.4e-17 60.7 12.9 2.3e-08 33.7 4.8 2.5 2 0 0 2 2 2 2 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 CRG90782.1 - 0.0011 18.8 4.7 0.009 15.9 0.6 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) RRM_1 PF00076.22 CRG90782.1 - 0.0018 18.1 0.0 0.0046 16.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DZR PF12773.7 CRG90782.1 - 0.045 13.8 5.1 0.27 11.3 0.8 2.5 2 0 0 2 2 2 0 Double zinc ribbon Complex1_30kDa PF00329.19 CRG90783.1 - 2.9e-45 153.8 0.0 4.1e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF5025 PF16428.5 CRG90783.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5025) Ig_mannosidase PF17753.1 CRG90784.1 - 4.1e-17 61.7 0.1 1e-16 60.4 0.1 1.7 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 CRG90784.1 - 9.3e-14 51.8 3.5 1.5e-13 51.1 0.3 3.0 3 0 0 3 3 3 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CRG90784.1 - 1.4e-09 38.6 0.1 1.2e-08 35.6 0.1 2.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 p450 PF00067.22 CRG90785.1 - 1.1e-44 153.0 0.0 1.3e-34 119.7 0.0 3.0 1 1 1 2 2 2 2 Cytochrome P450 Aldedh PF00171.22 CRG90787.1 - 9.3e-107 357.4 0.0 1.2e-106 357.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PNP_UDP_1 PF01048.20 CRG90788.1 - 1.2e-06 28.0 0.0 2.1e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG90788.1 - 0.021 15.2 0.0 0.05 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Glyco_hydro_3_C PF01915.22 CRG90789.1 - 4.7e-47 160.6 0.0 8e-47 159.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG90789.1 - 1.7e-44 152.5 0.0 2.7e-44 151.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Aminotran_3 PF00202.21 CRG90789.1 - 1.3e-20 73.4 0.0 2.1e-20 72.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Fn3-like PF14310.6 CRG90789.1 - 7.2e-18 64.5 0.3 1.3e-17 63.6 0.3 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Jacalin PF01419.17 CRG90790.1 - 1.8e-05 24.7 0.0 2.2e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Jacalin-like lectin domain Beta-prism_lec PF16458.5 CRG90790.1 - 0.024 14.6 0.2 0.75 9.8 0.0 2.2 2 1 0 2 2 2 0 Beta-prism lectin Pox_A_type_inc PF04508.12 CRG90791.1 - 2.2e-06 27.2 9.0 1.1 9.2 0.6 6.8 5 0 0 5 5 5 2 Viral A-type inclusion protein repeat Filament PF00038.21 CRG90791.1 - 0.0004 20.1 4.7 0.0004 20.1 4.7 8.7 1 1 4 6 6 6 4 Intermediate filament protein FAM184 PF15665.5 CRG90791.1 - 0.00054 19.8 33.6 0.00054 19.8 33.6 7.6 1 1 6 7 7 7 2 Family with sequence similarity 184, A and B Spc7 PF08317.11 CRG90791.1 - 0.24 10.2 177.4 0.0057 15.6 12.4 8.7 1 1 8 10 10 10 0 Spc7 kinetochore protein Myb_DNA-binding PF00249.31 CRG90792.1 - 3e-05 24.1 0.4 0.0008 19.6 0.1 2.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain LEDGF PF11467.8 CRG90792.1 - 0.012 15.3 0.8 0.74 9.4 0.2 2.5 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) Porin_10 PF14121.6 CRG90792.1 - 0.072 11.7 0.2 0.12 11.0 0.2 1.2 1 0 0 1 1 1 0 Putative porin PTPA PF03095.15 CRG90793.1 - 1e-107 360.1 0.0 1.3e-107 359.7 0.0 1.1 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF572 PF04502.13 CRG90794.1 - 6.3e-73 246.3 0.8 7.1e-73 246.1 0.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) PAW PF04721.17 CRG90794.1 - 0.054 13.3 0.7 8.9 6.0 0.2 2.2 2 0 0 2 2 2 0 PNGase C-terminal domain, mannose-binding module PAW PNP_UDP_1 PF01048.20 CRG90795.1 - 1.3e-39 135.9 0.3 1.6e-39 135.6 0.3 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily 6PGD PF00393.19 CRG90796.1 - 2.4e-84 283.2 0.0 3e-84 282.8 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CRG90796.1 - 7.7e-34 117.1 0.0 1.2e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 CRG90796.1 - 1.5e-06 28.2 0.2 2.4e-06 27.6 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 CRG90796.1 - 0.0052 17.0 0.0 0.031 14.5 0.0 2.1 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_Gly3P_dh_N PF01210.23 CRG90796.1 - 0.0054 16.7 0.0 0.0098 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 CRG90796.1 - 0.013 15.1 0.2 0.023 14.3 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 CRG90796.1 - 0.023 14.1 0.1 0.045 13.1 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 CRG90796.1 - 0.085 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PEPcase_2 PF14010.6 CRG90796.1 - 0.091 11.2 0.2 0.14 10.6 0.2 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase AP_endonuc_2 PF01261.24 CRG90797.1 - 5.1e-36 124.1 0.0 7e-36 123.7 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel AATase PF07247.12 CRG90798.1 - 1.2e-19 70.3 0.0 6.9e-19 67.8 0.0 2.1 1 1 0 1 1 1 1 Alcohol acetyltransferase AMP-binding PF00501.28 CRG90799.1 - 4.2e-63 213.4 0.0 9e-63 212.3 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme PTR2 PF00854.21 CRG90799.1 - 1.1e-23 83.8 0.0 2.6e-22 79.2 0.0 2.3 1 1 1 2 2 2 1 POT family AMP-binding_C PF13193.6 CRG90799.1 - 1.7e-15 57.7 0.1 7.4e-15 55.7 0.1 2.2 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain MFS_1 PF07690.16 CRG90799.1 - 0.00049 19.1 3.9 0.00049 19.1 3.9 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily LEM PF03020.15 CRG90799.1 - 0.053 13.1 0.1 1.3 8.7 0.0 2.5 2 0 0 2 2 2 0 LEM domain Thioesterase PF00975.20 CRG90800.1 - 4.1e-13 50.0 0.0 6.8e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CRG90800.1 - 0.00024 21.8 0.0 0.0003 21.5 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 CRG90800.1 - 0.0015 18.3 0.0 0.0038 17.0 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG90800.1 - 0.0017 18.0 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG90800.1 - 0.024 13.9 0.0 0.11 11.8 0.0 1.9 1 1 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 CRG90800.1 - 0.037 13.9 0.0 0.046 13.6 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CRG90800.1 - 0.057 13.2 0.0 0.08 12.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase LIDHydrolase PF10230.9 CRG90800.1 - 0.083 12.4 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase UPF0227 PF05728.12 CRG90800.1 - 0.094 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) AMP-binding PF00501.28 CRG90801.1 - 5.9e-221 733.5 0.0 1.6e-76 257.6 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 CRG90801.1 - 3e-157 523.9 0.0 7.1e-44 150.2 0.1 4.3 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.25 CRG90801.1 - 1.8e-62 207.6 6.9 8.9e-14 51.6 0.0 5.9 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG90801.1 - 4.8e-05 24.2 0.0 3.8 8.6 0.0 3.8 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain ketoacyl-synt PF00109.26 CRG90802.1 - 6.2e-73 245.5 0.0 1e-72 244.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG90802.1 - 8e-62 208.3 1.4 1.8e-61 207.2 1.2 1.8 2 0 0 2 2 1 1 KR domain PS-DH PF14765.6 CRG90802.1 - 1.3e-52 178.9 0.0 2.2e-52 178.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG90802.1 - 5.1e-47 160.9 0.0 8.6e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG90802.1 - 1.1e-38 131.9 0.0 2.8e-38 130.6 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG90802.1 - 4.5e-20 72.2 0.0 2e-19 70.2 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CRG90802.1 - 3.8e-19 70.0 0.0 1.2e-17 65.2 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG90802.1 - 1.2e-18 67.3 0.0 4.3e-18 65.5 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 CRG90802.1 - 5e-16 59.1 0.0 1.6e-15 57.5 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG90802.1 - 1.2e-14 54.2 0.7 2.8e-14 53.1 0.7 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_25 PF13649.6 CRG90802.1 - 1.9e-11 44.5 0.0 1.3e-10 41.8 0.0 2.6 3 0 0 3 3 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CRG90802.1 - 2.3e-10 40.4 0.4 4.6e-10 39.4 0.4 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_23 PF13489.6 CRG90802.1 - 4.2e-09 36.5 0.0 8.2e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG90802.1 - 1.7e-08 34.1 0.0 5e-08 32.6 0.0 1.7 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 CRG90802.1 - 1.8e-08 34.9 0.0 6.9e-08 33.0 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain PP-binding PF00550.25 CRG90802.1 - 7e-08 32.7 0.0 2e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 CRG90802.1 - 1.6e-06 28.0 0.0 3.5e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain SAT PF16073.5 CRG90802.1 - 7.3e-05 22.6 0.2 0.00015 21.6 0.2 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_16 PF10294.9 CRG90802.1 - 0.00013 21.8 0.0 0.00034 20.4 0.0 1.7 1 0 0 1 1 1 1 Lysine methyltransferase 3Beta_HSD PF01073.19 CRG90802.1 - 0.0012 18.0 0.0 0.002 17.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 CRG90802.1 - 0.02 14.3 0.0 0.054 12.8 0.0 1.7 1 0 0 1 1 1 0 Thiolase, N-terminal domain PCMT PF01135.19 CRG90802.1 - 0.023 14.4 0.0 0.061 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_28 PF02636.17 CRG90802.1 - 0.063 12.9 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DREV PF05219.12 CRG90802.1 - 0.079 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase p450 PF00067.22 CRG90803.1 - 1.3e-31 109.9 0.0 2.4e-31 109.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 PDCD7 PF16021.5 CRG90804.1 - 0.059 12.5 0.2 0.084 12.0 0.2 1.1 1 0 0 1 1 1 0 Programmed cell death protein 7 CIAPIN1 PF05093.13 CRG90805.1 - 2e-39 134.2 5.4 3.4e-39 133.4 5.4 1.4 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 CRG90805.1 - 9.6e-35 119.7 0.0 1.5e-34 119.1 0.0 1.3 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus WGG PF10273.9 CRG90806.1 - 5.1e-29 100.8 0.1 9.7e-29 99.9 0.1 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 Vfa1 PF08432.10 CRG90806.1 - 0.061 13.7 3.7 0.1 12.9 3.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NOA36 PF06524.12 CRG90806.1 - 4 6.7 11.7 5.2 6.3 11.7 1.1 1 0 0 1 1 1 0 NOA36 protein GTP_EFTU PF00009.27 CRG90807.1 - 3.8e-39 134.2 0.0 5.8e-39 133.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 CRG90807.1 - 6.9e-28 97.2 0.0 1.6e-27 96.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 CRG90807.1 - 9.5e-07 29.1 0.2 2.1e-06 28.0 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 CRG90807.1 - 0.018 15.1 0.0 0.077 13.1 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase Hamartin PF04388.12 CRG90807.1 - 0.13 10.9 1.2 0.17 10.5 1.2 1.1 1 0 0 1 1 1 0 Hamartin protein Mitofilin PF09731.9 CRG90807.1 - 0.17 10.7 8.1 0.22 10.3 8.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Ran-binding PF05508.11 CRG90808.1 - 7.4e-125 416.1 0.6 1e-124 415.6 0.6 1.2 1 0 0 1 1 1 1 RanGTP-binding protein BSD PF03909.17 CRG90809.1 - 1.2e-19 70.1 1.0 2.4e-19 69.1 1.0 1.6 1 0 0 1 1 1 1 BSD domain Suf PF05843.14 CRG90809.1 - 6.1 6.7 7.4 0.4 10.6 2.2 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Rad4 PF03835.15 CRG90811.1 - 1.6e-36 125.2 0.9 1.6e-36 125.2 0.9 2.1 2 0 0 2 2 2 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 CRG90811.1 - 2.2e-27 95.3 0.3 5.7e-27 93.9 0.1 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 CRG90811.1 - 8.2e-22 76.8 0.4 2.9e-21 75.1 0.4 2.0 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 CRG90811.1 - 3.1e-16 60.1 0.0 3.1e-16 60.1 0.0 3.0 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 CRG90811.1 - 0.0063 16.9 0.0 0.023 15.2 0.0 2.0 1 0 0 1 1 1 1 Transglutaminase-like superfamily E1_dh PF00676.20 CRG90812.1 - 4.2e-103 344.4 0.1 5e-103 344.2 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 CRG90812.1 - 0.0026 17.0 0.0 0.0049 16.1 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase COMM_domain PF07258.14 CRG90812.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 COMM domain Med8 PF10232.9 CRG90813.1 - 0.0069 16.0 0.1 0.01 15.5 0.1 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 ADH_zinc_N_2 PF13602.6 CRG90814.1 - 5.7e-14 53.3 0.0 1.1e-13 52.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG90814.1 - 9.7e-14 51.5 0.1 2e-12 47.2 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG90814.1 - 2.5e-05 24.1 0.7 5e-05 23.2 0.7 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain p450 PF00067.22 CRG90816.1 - 3e-78 263.6 0.0 3.6e-78 263.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF685 PF05085.12 CRG90818.1 - 0.21 10.9 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF685) Glyco_hydro_92 PF07971.12 CRG90819.1 - 3.9e-146 487.6 1.1 4.9e-146 487.3 1.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CRG90819.1 - 4e-64 216.8 2.4 4e-64 216.8 2.4 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 92 N-terminal domain PHD PF00628.29 CRG90820.1 - 1.2e-07 31.5 6.9 2.6e-07 30.4 6.9 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CRG90820.1 - 0.0022 17.5 3.8 0.013 15.1 1.8 2.3 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 CRG90820.1 - 0.0051 17.0 1.7 0.0051 17.0 1.7 1.8 2 0 0 2 2 2 1 PHD-like zinc-binding domain PHD_4 PF16866.5 CRG90820.1 - 0.88 9.7 9.8 4.9 7.3 9.6 2.2 1 1 0 1 1 1 0 PHD-finger C1_2 PF03107.16 CRG90820.1 - 1.1 9.6 7.4 0.34 11.3 3.8 1.9 2 0 0 2 2 2 0 C1 domain Zf_RING PF16744.5 CRG90820.1 - 5.4 7.2 8.0 3.8 7.7 3.1 2.4 2 0 0 2 2 2 0 KIAA1045 RING finger Zn_clus PF00172.18 CRG90821.1 - 3.5e-09 36.6 11.7 5.9e-09 35.9 11.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG90821.1 - 8.8e-09 34.6 0.0 3.3e-08 32.7 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain His_Phos_2 PF00328.22 CRG90822.1 - 4.9e-34 118.3 0.0 6.4e-34 117.9 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MFS_1 PF07690.16 CRG90823.1 - 2.5e-28 99.0 24.2 2.5e-28 99.0 24.2 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Peptidase_S10 PF00450.22 CRG90824.1 - 4e-131 438.3 0.4 5e-131 438.0 0.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 CRG90824.1 - 2.7e-16 60.3 0.0 6.9e-16 58.9 0.0 1.7 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide ApoLp-III PF07464.11 CRG90824.1 - 0.0042 17.2 0.0 0.0086 16.2 0.0 1.4 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Pox_Ag35 PF03286.14 CRG90824.1 - 0.044 13.6 0.1 0.065 13.0 0.1 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ribosomal_S13 PF00416.22 CRG90825.1 - 2.7e-56 189.5 3.2 3.1e-56 189.2 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 CRG90825.1 - 0.049 12.4 0.0 0.05 12.4 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 CRG90825.1 - 0.087 13.1 0.1 0.27 11.5 0.1 1.8 1 1 0 1 1 1 0 Helix-hairpin-helix motif Med4 PF10018.9 CRG90826.1 - 4.3e-42 144.0 0.5 5.9e-42 143.6 0.5 1.2 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 SBDS_C PF09377.10 CRG90828.1 - 3.8e-43 146.2 0.0 5.9e-43 145.6 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 CRG90828.1 - 1.8e-31 108.1 0.1 3.3e-31 107.2 0.1 1.5 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Pyr_redox_2 PF07992.14 CRG90829.1 - 4e-35 121.5 0.0 4.9e-33 114.6 0.0 2.0 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG90829.1 - 2.3e-11 44.1 1.3 7.9e-08 32.8 0.0 3.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG90829.1 - 1.7e-05 24.2 0.1 0.0011 18.2 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG90829.1 - 0.0069 16.0 14.2 2.5 7.6 1.6 4.7 3 1 2 5 5 5 3 FAD dependent oxidoreductase Trp_halogenase PF04820.14 CRG90829.1 - 0.26 10.1 1.9 17 4.1 0.6 3.0 3 0 0 3 3 3 0 Tryptophan halogenase Zn_clus PF00172.18 CRG90830.1 - 9.7e-08 32.0 13.4 9.7e-08 32.0 13.4 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RuvA_C PF07499.13 CRG90830.1 - 0.055 13.9 0.0 0.14 12.6 0.0 1.7 1 0 0 1 1 1 0 RuvA, C-terminal domain Herpes_IE2_3 PF03361.14 CRG90830.1 - 0.059 13.2 0.2 0.17 11.8 0.0 1.8 2 0 0 2 2 2 0 Herpes virus intermediate/early protein 2/3 Rhabdo_ncap PF00945.18 CRG90830.1 - 0.095 11.6 0.2 0.15 11.0 0.2 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein RabGAP-TBC PF00566.18 CRG90832.1 - 1.5e-49 168.6 1.5 6.4e-49 166.5 0.0 2.7 3 1 1 4 4 4 1 Rab-GTPase-TBC domain TACC_C PF05010.14 CRG90832.1 - 2.1 8.1 18.2 0.065 13.0 9.8 2.5 2 1 0 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TPR_MLP1_2 PF07926.12 CRG90832.1 - 5.9 7.0 23.1 0.27 11.3 4.8 3.7 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-K PF11802.8 CRG90832.1 - 8.3 5.9 15.3 0.5 9.9 6.4 2.5 1 1 0 2 2 2 0 Centromere-associated protein K DNA_topoisoIV PF00521.20 CRG90833.1 - 5.4e-137 457.2 1.2 8.6e-137 456.5 0.2 1.8 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 CRG90833.1 - 1.7e-53 180.3 4.6 6.6e-53 178.4 4.6 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 CRG90833.1 - 5.6e-26 91.1 2.2 1.6e-25 89.6 2.2 1.8 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 CRG90833.1 - 1e-14 55.0 0.0 3.1e-14 53.4 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 CRG90833.1 - 5.4e-07 29.8 0.0 3.9e-06 27.0 0.0 2.6 2 0 0 2 2 2 1 Toprim domain Glyoxal_oxid_N PF07250.11 CRG90833.1 - 0.13 11.4 0.0 0.32 10.2 0.0 1.5 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus Reticulon PF02453.17 CRG90835.1 - 8.5e-28 97.3 3.3 1.3e-27 96.7 3.3 1.3 1 0 0 1 1 1 1 Reticulon Trypan_PARP PF05887.11 CRG90835.1 - 0.05 13.6 13.0 0.46 10.5 11.7 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Pex24p PF06398.11 CRG90835.1 - 2.1 7.2 4.3 4.3 6.2 4.3 1.7 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin INCENP_ARK-bind PF03941.15 CRG90836.1 - 5.7e-15 55.0 2.1 2.2e-14 53.1 2.1 2.2 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region TPR_12 PF13424.6 CRG90837.1 - 2.4e-27 95.0 8.9 4.6e-10 39.7 0.0 4.6 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 CRG90837.1 - 3.2e-21 74.5 17.1 2.8e-05 23.8 0.6 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 CRG90837.1 - 1.5e-10 40.4 8.3 0.76 9.9 0.1 7.4 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 CRG90837.1 - 3.3e-10 40.4 5.7 0.047 14.3 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG90837.1 - 7.1e-08 32.9 2.8 0.2 12.2 0.2 5.4 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG90837.1 - 8.1e-08 32.0 8.2 0.0023 17.4 0.2 3.6 2 1 2 4 4 4 2 MalT-like TPR region TPR_14 PF13428.6 CRG90837.1 - 1.7e-07 31.4 8.5 0.53 11.3 0.2 6.6 7 1 1 8 8 7 2 Tetratricopeptide repeat PPR PF01535.20 CRG90837.1 - 5.8e-05 23.1 0.1 5 7.6 0.0 4.6 4 0 0 4 4 4 1 PPR repeat TPR_8 PF13181.6 CRG90837.1 - 0.00019 21.4 0.1 14 6.2 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG90837.1 - 0.00021 21.6 6.4 0.24 12.2 1.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG90837.1 - 0.00075 19.4 3.1 9.9 6.6 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG90837.1 - 0.0054 16.5 1.9 61 3.7 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 CRG90837.1 - 0.028 14.1 0.5 2 8.1 0.0 3.6 3 1 0 3 3 3 0 TPR repeat ANAPC3 PF12895.7 CRG90837.1 - 0.029 14.6 0.1 7.8 6.8 0.0 3.6 3 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.7 CRG90837.1 - 0.039 14.2 0.8 1.6 9.0 0.3 2.8 2 0 0 2 2 2 0 Tetratrico peptide repeat TPR_20 PF14561.6 CRG90837.1 - 0.62 10.4 2.8 4.3 7.7 0.1 3.3 5 0 0 5 5 4 0 Tetratricopeptide repeat PPR_1 PF12854.7 CRG90837.1 - 0.8 9.5 2.5 18 5.1 0.0 3.5 4 0 0 4 4 4 0 PPR repeat TPR_6 PF13174.6 CRG90837.1 - 4.6 8.1 7.6 1.1e+02 3.7 0.0 5.4 8 0 0 8 8 6 0 Tetratricopeptide repeat PDZ_1 PF12812.7 CRG90839.1 - 1.7e-52 175.4 0.0 1.7e-34 117.6 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 CRG90839.1 - 5.6e-26 92.2 2.3 3.8e-21 76.5 0.1 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 CRG90839.1 - 7.2e-15 54.6 0.3 9.6e-09 35.0 0.4 3.5 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 CRG90839.1 - 2.9e-12 46.8 0.2 4.9e-06 26.8 0.0 3.9 4 0 0 4 4 3 2 PDZ domain PDZ PF00595.24 CRG90839.1 - 6.1e-10 39.3 0.0 0.00017 21.9 0.0 3.6 3 0 0 3 3 3 2 PDZ domain Trypsin PF00089.26 CRG90839.1 - 8.6e-05 22.4 0.1 0.00036 20.4 0.1 2.1 1 1 0 1 1 1 1 Trypsin 4HPAD_g_N PF18671.1 CRG90839.1 - 0.00041 20.0 0.0 0.0027 17.4 0.0 2.3 2 0 0 2 2 2 1 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal Tricorn_PDZ PF14685.6 CRG90839.1 - 0.0063 16.5 0.4 0.26 11.3 0.1 3.2 3 0 0 3 3 3 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 CRG90839.1 - 0.012 14.3 0.2 0.025 13.3 0.2 1.4 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S7 PF00949.21 CRG90839.1 - 0.036 13.9 0.1 0.088 12.6 0.1 1.6 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease DUF31 PF01732.16 CRG90839.1 - 0.046 13.3 0.3 0.073 12.6 0.3 1.3 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S29 PF02907.15 CRG90839.1 - 0.05 13.3 0.2 0.96 9.2 0.0 2.4 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease SSXT PF05030.12 CRG90840.1 - 8.2e-07 28.6 0.4 0.0077 15.8 0.0 3.2 3 0 0 3 3 3 2 SSXT protein (N-terminal region) MFS_1 PF07690.16 CRG90841.1 - 1.8e-33 115.9 49.7 1.8e-32 112.6 49.7 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90841.1 - 6.8e-13 48.3 11.5 6.8e-13 48.3 11.5 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter Fungal_trans PF04082.18 CRG90842.1 - 1.4e-12 47.2 0.0 2.7e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF3328 PF11807.8 CRG90843.1 - 1.1e-20 74.3 0.0 1.4e-20 74.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) ABC_tran PF00005.27 CRG90845.1 - 2.4e-42 144.7 0.0 3.8e-22 79.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG90845.1 - 2e-21 76.9 13.4 2e-21 76.9 13.4 3.3 2 1 1 3 3 3 1 ABC transporter transmembrane region SMC_N PF02463.19 CRG90845.1 - 2.5e-10 40.2 4.2 0.0038 16.7 0.0 4.2 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG90845.1 - 3.2e-10 40.3 4.3 0.089 12.6 0.1 4.4 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 CRG90845.1 - 2.4e-08 34.0 0.0 0.00083 19.4 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 CRG90845.1 - 5.3e-06 26.1 0.9 0.021 14.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain Dynamin_N PF00350.23 CRG90845.1 - 9.4e-06 25.8 1.0 0.0091 16.1 0.0 2.4 2 0 0 2 2 2 2 Dynamin family AAA_23 PF13476.6 CRG90845.1 - 0.00017 22.2 1.2 0.36 11.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG90845.1 - 0.00032 21.1 4.6 0.031 14.6 0.1 3.0 2 1 0 2 2 2 1 AAA ATPase domain Zeta_toxin PF06414.12 CRG90845.1 - 0.00035 19.9 0.2 0.79 9.0 0.1 2.3 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 CRG90845.1 - 0.00058 19.8 1.4 1 9.3 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase NACHT PF05729.12 CRG90845.1 - 0.0016 18.3 2.1 0.11 12.3 0.1 3.1 2 0 0 2 2 2 1 NACHT domain FtsK_SpoIIIE PF01580.18 CRG90845.1 - 0.0023 17.3 1.0 1.2 8.5 0.1 2.4 2 0 0 2 2 2 2 FtsK/SpoIIIE family T2SSE PF00437.20 CRG90845.1 - 0.0026 16.9 0.5 2.1 7.3 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein DUF87 PF01935.17 CRG90845.1 - 0.0028 17.8 3.3 0.051 13.7 0.3 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain cobW PF02492.19 CRG90845.1 - 0.003 17.2 1.2 0.25 10.9 0.1 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CRG90845.1 - 0.003 17.8 6.4 0.54 10.5 0.2 3.8 2 2 0 2 2 2 1 AAA domain MeaB PF03308.16 CRG90845.1 - 0.0047 15.9 1.0 0.45 9.4 0.1 2.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 CRG90845.1 - 0.0098 15.6 0.2 0.72 9.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain NB-ARC PF00931.22 CRG90845.1 - 0.01 15.0 5.5 0.93 8.6 1.2 3.2 2 1 0 2 2 2 0 NB-ARC domain DUF815 PF05673.13 CRG90845.1 - 0.012 14.8 0.1 5.2 6.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Adeno_IVa2 PF02456.15 CRG90845.1 - 0.014 14.2 1.2 2.2 7.0 0.2 2.4 2 0 0 2 2 2 0 Adenovirus IVa2 protein ATPase_2 PF01637.18 CRG90845.1 - 0.014 15.3 0.1 1.7 8.5 0.0 2.6 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea SbcCD_C PF13558.6 CRG90845.1 - 0.02 15.1 0.3 4.4 7.6 0.1 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit TsaE PF02367.17 CRG90845.1 - 0.021 14.8 0.4 0.52 10.3 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 CRG90845.1 - 0.021 14.5 0.1 1.1 9.0 0.0 2.6 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.14 CRG90845.1 - 0.024 13.9 0.3 5 6.3 0.1 2.6 2 0 0 2 2 2 0 KAP family P-loop domain Roc PF08477.13 CRG90845.1 - 0.041 14.1 2.1 1.3 9.2 0.0 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 CRG90845.1 - 0.046 13.9 0.1 2 8.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG90845.1 - 0.047 14.1 0.1 20 5.6 0.1 2.9 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 CRG90845.1 - 0.067 12.9 0.5 1.1 8.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CRG90845.1 - 0.1 13.0 1.1 20 5.6 0.2 3.9 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 CRG90845.1 - 0.17 11.4 0.3 13 5.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 CRG90845.1 - 0.19 11.2 1.6 9.8 5.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain ABC_ATPase PF09818.9 CRG90845.1 - 0.22 10.3 2.1 9.4 4.9 0.0 3.0 3 0 0 3 3 3 0 Predicted ATPase of the ABC class DEAD PF00270.29 CRG90845.1 - 0.31 10.8 1.7 49 3.6 0.0 3.3 3 0 0 3 3 3 0 DEAD/DEAH box helicase DAP3 PF10236.9 CRG90845.1 - 0.32 10.1 2.1 11 5.1 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_18 PF13238.6 CRG90845.1 - 0.4 11.2 1.0 26 5.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 CRG90845.1 - 0.42 9.5 3.7 9.1 5.1 0.4 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain TPR_2 PF07719.17 CRG90847.1 - 5.4e-11 41.7 3.5 0.0076 16.3 0.3 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 CRG90847.1 - 1.8e-10 40.2 4.4 0.00011 21.9 0.6 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG90847.1 - 0.00021 21.2 2.5 2.2 8.7 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG90847.1 - 0.005 17.3 1.1 0.014 15.9 0.1 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG90847.1 - 0.01 16.1 0.6 0.022 15.0 0.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 CRG90847.1 - 0.015 15.4 0.7 1.4 9.0 0.2 3.1 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Pox_T4_N PF04491.12 CRG90847.1 - 0.028 14.3 0.0 0.11 12.4 0.0 2.0 1 0 0 1 1 1 0 Poxvirus T4 protein, N terminus TPR_17 PF13431.6 CRG90847.1 - 0.087 13.3 2.2 0.76 10.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat RBD-FIP PF09457.10 CRG90847.1 - 0.11 12.4 0.0 0.44 10.5 0.0 2.1 2 0 0 2 2 2 0 FIP domain ArAE_2_N PF10337.9 CRG90848.1 - 9.2e-44 150.3 7.9 1.8e-41 142.7 7.9 2.7 1 1 0 1 1 1 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 CRG90848.1 - 2.8e-13 50.1 16.6 2.8e-13 50.1 16.6 2.8 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 CRG90848.1 - 1.8e-06 28.0 0.1 0.00034 20.5 0.0 2.9 3 0 0 3 3 3 2 Aromatic acid exporter family member 2 Ifi-6-16 PF06140.13 CRG90849.1 - 2.8e-07 30.3 0.1 3.2e-06 27.0 0.0 2.1 1 1 1 2 2 2 1 Interferon-induced 6-16 family DUF2754 PF10953.8 CRG90849.1 - 0.16 12.2 2.6 0.65 10.3 2.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2754) BTB PF00651.31 CRG90850.1 - 3.2e-16 59.6 0.0 6.4e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 CRG90850.1 - 0.084 13.0 0.1 0.74 10.0 0.1 2.2 1 1 1 2 2 2 0 BTB And C-terminal Kelch SET_assoc PF11767.8 CRG90850.1 - 0.095 12.4 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DUF2752 PF10825.8 CRG90850.1 - 0.27 11.3 0.8 35 4.6 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2752) Ank_2 PF12796.7 CRG90851.1 - 1.4e-25 89.7 1.7 1.1e-11 45.2 0.0 3.5 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG90851.1 - 2.9e-22 78.7 0.1 9.6e-05 22.9 0.0 5.6 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG90851.1 - 1.8e-19 67.7 0.7 0.014 15.8 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 CRG90851.1 - 3.7e-17 61.9 3.9 0.012 16.0 0.0 6.3 7 0 0 7 7 7 5 Ankyrin repeat Ank_5 PF13857.6 CRG90851.1 - 9.1e-15 54.5 5.7 0.015 15.6 0.2 6.1 3 2 3 6 6 6 5 Ankyrin repeats (many copies) HicA_toxin PF07927.12 CRG90851.1 - 0.05 13.6 0.1 2.8 8.0 0.0 3.0 3 0 0 3 3 3 0 HicA toxin of bacterial toxin-antitoxin, PUA_3 PF17785.1 CRG90851.1 - 0.14 11.9 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 PUA-like domain SUIM_assoc PF16619.5 CRG90852.1 - 0.019 15.0 1.3 0.019 15.0 1.3 7.9 7 1 0 7 7 7 0 Unstructured region C-term to UIM in Ataxin3 ADH_zinc_N_2 PF13602.6 CRG90853.1 - 1.8e-10 42.0 0.0 3.9e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG90853.1 - 1.6e-09 37.6 0.0 1.9e-08 34.1 0.0 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG90853.1 - 0.00051 20.0 0.0 0.00098 19.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Pyridoxal_deC PF00282.19 CRG90854.1 - 7.5e-78 261.8 0.0 1.1e-77 261.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CRG90854.1 - 0.00023 20.2 0.0 0.00038 19.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 CRG90854.1 - 0.017 13.8 0.0 0.025 13.3 0.0 1.2 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain F-box PF00646.33 CRG90856.1 - 1.2e-05 25.1 1.1 0.00012 21.9 0.1 2.6 2 0 0 2 2 2 1 F-box domain MEA1 PF06910.11 CRG90856.1 - 0.02 15.5 0.0 0.042 14.5 0.0 1.5 1 0 0 1 1 1 0 Male enhanced antigen 1 (MEA1) F-box_4 PF15966.5 CRG90856.1 - 0.027 14.3 1.5 0.1 12.5 0.0 2.2 2 0 0 2 2 2 0 F-box CN_hydrolase PF00795.22 CRG90857.1 - 6e-31 107.7 0.0 1.7e-30 106.3 0.0 1.7 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase MMS1_N PF10433.9 CRG90858.1 - 4.5e-160 533.5 0.0 6.4e-160 533.0 0.0 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 CRG90858.1 - 2.2e-97 326.2 0.0 1.7e-96 323.3 0.0 2.2 2 0 0 2 2 2 1 CPSF A subunit region ANAPC4_WD40 PF12894.7 CRG90858.1 - 0.021 15.1 0.0 0.3 11.4 0.0 2.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain ubiquitin PF00240.23 CRG90859.1 - 1.2e-20 73.0 0.0 1.8e-20 72.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 CRG90859.1 - 4.8e-09 35.9 0.1 1.1e-08 34.8 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD PF11976.8 CRG90859.1 - 4.4e-08 32.8 0.0 7.2e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CRG90859.1 - 2.8e-06 27.8 0.1 5.5e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 CRG90859.1 - 2.9e-06 27.3 0.0 4.8e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 CRG90859.1 - 0.0011 19.6 0.0 0.0027 18.4 0.0 1.7 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.6 CRG90859.1 - 0.012 16.0 0.1 0.041 14.3 0.1 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain Blt1 PF12754.7 CRG90859.1 - 0.17 12.2 0.3 0.29 11.5 0.3 1.5 1 0 0 1 1 1 0 Blt1 N-terminal domain HOIP-UBA PF16678.5 CRG90859.1 - 0.19 11.7 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair Plexin_cytopl PF08337.12 CRG90859.1 - 0.25 9.9 0.2 0.61 8.7 0.1 1.4 1 1 1 2 2 2 0 Plexin cytoplasmic RasGAP domain STI1 PF17830.1 CRG90859.1 - 0.31 11.0 23.9 1.1 9.2 0.0 4.2 3 1 1 4 4 4 0 STI1 domain XPC-binding PF09280.11 CRG90859.1 - 0.81 9.5 10.8 20 5.0 0.0 3.5 2 1 1 3 3 3 0 XPC-binding domain GerD PF17898.1 CRG90859.1 - 1.4 8.9 4.3 4 7.4 4.0 1.9 1 1 0 1 1 1 0 Spore germination GerD central core domain EMP70 PF02990.16 CRG90860.1 - 5.6e-197 655.5 0.0 6.7e-197 655.3 0.0 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 DUF4451 PF14616.6 CRG90861.1 - 0.16 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) Sulfatase PF00884.23 CRG90862.1 - 3.6e-60 204.0 0.2 4.8e-60 203.6 0.2 1.2 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 CRG90862.1 - 6.7e-21 73.8 0.5 1.5e-20 72.7 0.5 1.6 1 0 0 1 1 1 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 CRG90862.1 - 9.4e-11 41.9 0.2 1.7e-09 37.8 0.2 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF4976 PF16347.5 CRG90862.1 - 0.0027 18.0 0.0 0.0078 16.4 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) DUF229 PF02995.17 CRG90862.1 - 0.0029 16.3 0.0 0.0038 15.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF1501 PF07394.12 CRG90862.1 - 0.0058 15.7 0.0 0.0088 15.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) Sulfatase_C PF14707.6 CRG90862.1 - 0.013 16.2 0.3 0.037 14.7 0.1 1.8 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase Metalloenzyme PF01676.18 CRG90862.1 - 0.034 13.5 0.0 0.091 12.1 0.0 1.7 2 0 0 2 2 2 0 Metalloenzyme superfamily Bul1_N PF04425.12 CRG90863.1 - 3.1e-06 26.2 3.4 3.1e-06 26.2 3.4 2.4 2 1 1 3 3 3 1 Bul1 N terminus Arrestin_N PF00339.29 CRG90863.1 - 8.7e-05 22.6 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 CRG90863.1 - 0.00047 19.7 0.0 0.00077 19.0 0.0 1.3 1 0 0 1 1 1 1 Bul1 C terminus SSF PF00474.17 CRG90864.1 - 8e-20 71.1 30.7 8e-20 71.1 30.7 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family Bac_luciferase PF00296.20 CRG90865.1 - 4.4e-58 197.2 3.7 5.8e-58 196.8 3.7 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase BP28CT PF08146.12 CRG90866.1 - 4.6e-43 146.8 1.1 1.3e-42 145.4 0.1 2.4 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 CRG90866.1 - 5.1e-26 91.3 4.6 9e-26 90.5 0.3 3.7 3 1 0 3 3 3 1 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 CRG90866.1 - 0.0024 18.2 9.8 0.77 10.2 0.4 6.0 7 1 0 7 7 7 1 HEAT repeats Tti2 PF10521.9 CRG90866.1 - 0.003 17.2 0.1 0.11 12.0 0.0 3.0 2 0 0 2 2 2 1 Tti2 family EST1_DNA_bind PF10373.9 CRG90866.1 - 0.065 12.7 0.8 0.59 9.6 0.2 2.7 2 1 0 2 2 2 0 Est1 DNA/RNA binding domain HEAT_EZ PF13513.6 CRG90866.1 - 0.095 13.2 12.5 1 9.9 0.7 6.7 8 0 0 8 8 8 0 HEAT-like repeat TIP120 PF08623.10 CRG90866.1 - 0.13 12.1 0.5 2.8 7.7 0.0 3.5 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) HEAT PF02985.22 CRG90866.1 - 0.37 11.2 5.3 45 4.7 0.0 5.8 6 0 0 6 6 6 0 HEAT repeat UNC45-central PF11701.8 CRG90866.1 - 0.44 10.5 5.8 16 5.4 0.1 5.0 4 1 1 5 5 5 0 Myosin-binding striated muscle assembly central NRDE-2 PF08424.10 CRG90867.1 - 1.4e-94 316.9 1.2 2e-94 316.4 0.1 1.9 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference Peptidase_S49_N PF08496.10 CRG90867.1 - 0.068 13.2 1.9 0.088 12.9 0.4 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TPR_14 PF13428.6 CRG90867.1 - 0.083 13.8 9.2 0.14 13.1 0.2 5.1 7 0 0 7 7 7 0 Tetratricopeptide repeat FAD_binding_8 PF08022.12 CRG90868.1 - 9.8e-22 77.1 0.0 2e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CRG90868.1 - 4.2e-20 72.1 7.7 4.2e-20 72.1 7.7 2.0 1 1 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG90868.1 - 2.9e-19 69.7 0.0 5.2e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_6 PF00970.24 CRG90868.1 - 0.082 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Ntox3 PF15536.6 CRG90868.1 - 0.099 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial toxin 3 UDG PF03167.19 CRG90870.1 - 1.8e-17 63.8 0.0 2.7e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily SBDS PF01172.18 CRG90871.1 - 8.6e-26 89.9 0.1 1.1e-25 89.5 0.1 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Phage_TAC_5 PF08890.11 CRG90871.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC RhoGEF PF00621.20 CRG90872.1 - 9.1e-16 58.6 0.0 1.6e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 CRG90872.1 - 0.0074 16.8 0.0 0.02 15.4 0.0 1.8 1 0 0 1 1 1 1 PH domain Ras PF00071.22 CRG90873.1 - 7.4e-41 139.5 0.0 1.2e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Nas2_N PF18265.1 CRG90873.1 - 7.3e-28 96.3 0.1 1.3e-27 95.5 0.1 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain Roc PF08477.13 CRG90873.1 - 5.1e-21 75.1 0.0 1.3e-20 73.8 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PDZ_6 PF17820.1 CRG90873.1 - 1.4e-12 47.2 0.8 2.5e-12 46.4 0.8 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 CRG90873.1 - 1.5e-07 31.6 0.6 4.2e-07 30.2 0.1 2.0 2 0 0 2 2 2 1 PDZ domain GRASP55_65 PF04495.14 CRG90873.1 - 8.9e-06 26.1 0.0 1.7e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain Arf PF00025.21 CRG90873.1 - 2.9e-05 23.6 0.0 5.2e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family PDZ PF00595.24 CRG90873.1 - 0.00021 21.6 0.1 0.00039 20.7 0.1 1.5 1 0 0 1 1 1 1 PDZ domain Fucokinase PF07959.12 CRG90873.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 L-fucokinase SNF2_N PF00176.23 CRG90874.1 - 8.8e-63 212.1 0.1 1.7e-62 211.2 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG90874.1 - 2e-17 63.5 0.0 9e-17 61.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 CRG90874.1 - 3e-09 36.6 4.1 5.5e-09 35.7 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG90874.1 - 1.2e-07 31.5 1.5 1.2e-07 31.5 1.5 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 CRG90874.1 - 6e-06 26.5 4.7 1.4e-05 25.4 4.7 1.6 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 CRG90874.1 - 9e-06 25.8 0.0 2.8e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 CRG90874.1 - 9.3e-05 22.4 2.6 0.0002 21.3 2.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 CRG90874.1 - 0.00012 21.9 5.0 0.00027 20.8 5.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG90874.1 - 0.00032 20.6 4.9 0.0007 19.5 4.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG90874.1 - 0.00041 20.2 5.2 0.0014 18.4 5.2 1.9 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 CRG90874.1 - 0.00045 19.9 4.4 0.00098 18.9 4.4 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain SPT6_acidic PF14632.6 CRG90874.1 - 0.011 16.2 13.1 0.011 16.2 13.1 2.4 2 0 0 2 2 2 0 Acidic N-terminal SPT6 zf-RING_14 PF17978.1 CRG90874.1 - 0.058 13.8 0.7 0.13 12.7 0.7 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 CRG90874.1 - 0.088 12.6 0.5 0.21 11.4 0.5 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 CRG90874.1 - 0.11 12.7 6.0 0.25 11.5 6.0 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CDC45 PF02724.14 CRG90874.1 - 0.37 9.0 12.1 0.65 8.2 12.1 1.3 1 0 0 1 1 1 0 CDC45-like protein DZR PF12773.7 CRG90874.1 - 0.52 10.4 5.8 1.4 9.0 5.9 1.7 1 1 0 1 1 1 0 Double zinc ribbon DUF3188 PF11384.8 CRG90875.1 - 5.9e-05 22.7 0.6 9.2e-05 22.1 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3188) TMEM154 PF15102.6 CRG90875.1 - 0.0098 15.8 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family DAG1 PF05454.11 CRG90875.1 - 0.055 12.8 0.0 0.055 12.8 0.0 1.7 2 0 0 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF3185 PF11381.8 CRG90875.1 - 0.07 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) EphA2_TM PF14575.6 CRG90875.1 - 0.1 13.5 0.0 0.18 12.7 0.0 1.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM171 PF15471.6 CRG90875.1 - 1.3 8.0 0.0 1.3 8.0 0.0 1.9 2 0 0 2 2 2 0 Transmembrane protein family 171 F-actin_cap_A PF01267.17 CRG90877.1 - 4.7e-96 321.3 0.0 5.4e-96 321.1 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit Fungal_trans_2 PF11951.8 CRG90878.1 - 2.3e-06 26.7 3.7 3.4e-06 26.1 3.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain NmrA PF05368.13 CRG90879.1 - 3.9e-17 62.6 0.0 5.4e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG90879.1 - 4.1e-14 52.9 0.1 6.1e-14 52.3 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG90879.1 - 5.8e-09 36.3 0.1 9.4e-09 35.6 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG90879.1 - 4.9e-06 26.2 0.1 7.4e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CRG90879.1 - 1.2e-05 25.4 0.2 2.1e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 CRG90879.1 - 0.00011 22.6 0.2 0.0002 21.8 0.2 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CRG90879.1 - 0.00039 19.6 0.4 0.00058 19.0 0.4 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain ApbA PF02558.16 CRG90879.1 - 0.0023 17.6 0.2 0.0037 16.9 0.2 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 CRG90879.1 - 0.0026 18.0 0.2 0.0048 17.1 0.2 1.5 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.10 CRG90879.1 - 0.0028 17.6 0.1 0.0044 17.0 0.1 1.2 1 0 0 1 1 1 1 KR domain Shikimate_DH PF01488.20 CRG90879.1 - 0.0032 17.6 0.2 0.0055 16.8 0.2 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase PglD_N PF17836.1 CRG90879.1 - 0.005 17.4 0.1 0.14 12.8 0.1 2.4 2 0 0 2 2 2 1 PglD N-terminal domain 3Beta_HSD PF01073.19 CRG90879.1 - 0.0078 15.3 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Ldh_1_N PF00056.23 CRG90879.1 - 0.099 12.7 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain SET PF00856.28 CRG90880.1 - 2.1e-11 44.5 0.0 3.5e-10 40.5 0.0 2.8 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 CRG90880.1 - 0.015 15.3 0.5 1.3 9.3 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat Ferritin_2 PF13668.6 CRG90881.1 - 4.7e-14 52.8 0.0 8.3e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Ferritin-like domain PEX11 PF05648.14 CRG90882.1 - 8.2e-30 103.9 0.0 9.5e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) adh_short PF00106.25 CRG90883.1 - 5.4e-15 55.4 0.1 9.3e-15 54.6 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG90883.1 - 2.2e-09 37.5 0.9 3.7e-09 36.7 0.0 1.7 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 CRG90883.1 - 6.3e-06 25.9 0.0 1.2e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Fungal_trans_2 PF11951.8 CRG90884.1 - 6.6e-07 28.5 2.3 6.6e-07 28.5 2.3 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Amidohydro_1 PF01979.20 CRG90885.1 - 1.2e-55 189.2 0.0 1.6e-55 188.8 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG90885.1 - 1.8e-06 27.7 0.0 0.0015 18.0 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family A_deaminase PF00962.22 CRG90885.1 - 0.0012 18.3 0.0 0.0022 17.4 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase 2-Hacid_dh_C PF02826.19 CRG90886.1 - 2.3e-44 150.9 0.0 4.9e-44 149.8 0.0 1.5 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 CRG90886.1 - 6.2e-09 35.6 0.0 9.1e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 CRG90886.1 - 0.017 15.3 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase THDPS_N_2 PF14805.6 CRG90886.1 - 0.091 13.0 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Gp_dh_N PF00044.24 CRG90886.1 - 0.18 12.1 0.0 0.41 11.0 0.0 1.6 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Fungal_trans PF04082.18 CRG90889.1 - 5e-25 88.0 0.0 1.4e-24 86.6 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90889.1 - 1.1e-08 35.0 7.1 1.8e-08 34.3 7.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GCP5-Mod21 PF14609.6 CRG90889.1 - 0.12 10.7 0.0 0.24 9.7 0.0 1.4 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 DAO PF01266.24 CRG90890.1 - 1.2e-25 90.9 0.0 1.4e-25 90.6 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG90890.1 - 0.00036 19.9 0.0 0.00049 19.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG90890.1 - 0.0013 17.9 0.2 0.0027 16.9 0.1 1.5 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 CRG90890.1 - 0.0014 17.8 0.4 0.0019 17.4 0.4 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A ApbA PF02558.16 CRG90890.1 - 0.0035 17.0 1.0 0.0062 16.2 1.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_8 PF13450.6 CRG90890.1 - 0.01 16.1 0.4 0.025 14.8 0.4 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG90890.1 - 0.038 14.6 0.2 0.071 13.7 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG90890.1 - 0.066 12.6 0.1 0.12 11.7 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 CRG90890.1 - 0.078 12.8 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CRG90890.1 - 0.15 11.2 0.3 0.22 10.7 0.3 1.1 1 0 0 1 1 1 0 FAD binding domain DUF604 PF04646.12 CRG90890.1 - 0.26 10.6 0.4 0.41 10.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF604 OPT PF03169.15 CRG90891.1 - 6.6e-160 533.7 61.8 7.7e-160 533.5 61.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Glyco_hydro_25 PF01183.20 CRG90892.1 - 9.9e-44 149.6 0.1 1.1e-43 149.4 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 Ank_2 PF12796.7 CRG90893.1 - 1.4e-50 169.8 16.2 5.8e-16 58.8 0.3 5.0 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG90893.1 - 1.4e-41 140.4 9.6 1.2e-10 41.7 0.2 5.7 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG90893.1 - 1.8e-40 132.3 3.8 3.6e-05 23.8 0.0 7.4 7 0 0 7 7 7 7 Ankyrin repeat Ank PF00023.30 CRG90893.1 - 4.1e-33 112.4 16.7 4.8e-06 26.8 0.2 6.9 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 CRG90893.1 - 3.6e-31 106.8 18.1 2e-06 28.0 0.1 7.1 2 1 5 7 7 7 7 Ankyrin repeats (many copies) DUF2384 PF09722.10 CRG90893.1 - 0.29 11.2 3.2 31 4.7 0.0 4.6 6 0 0 6 6 6 0 Protein of unknown function (DUF2384) Metallophos PF00149.28 CRG90894.1 - 1.2e-31 110.8 0.7 2.4e-31 109.8 0.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 CRG90894.1 - 7.6e-14 52.3 0.2 2.8e-13 50.5 0.2 2.1 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 CRG90894.1 - 6.4e-13 49.1 0.2 1.6e-12 47.8 0.2 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 CRG90894.1 - 0.024 15.1 0.1 0.059 13.9 0.1 1.6 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain fn3 PF00041.21 CRG90894.1 - 0.025 14.9 0.1 0.058 13.8 0.1 1.6 1 0 0 1 1 1 0 Fibronectin type III domain Metallophos_2 PF12850.7 CRG90894.1 - 0.18 12.0 0.0 0.57 10.4 0.0 1.7 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Gpr1_Fun34_YaaH PF01184.19 CRG90896.1 - 2.7e-26 92.5 19.7 3.3e-26 92.2 19.7 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Deltameth_res PF16020.5 CRG90896.1 - 0.29 11.0 1.8 1.7 8.6 0.1 2.7 2 0 0 2 2 2 0 Deltamethrin resistance ADH_zinc_N PF00107.26 CRG90897.1 - 4e-24 85.1 0.3 8.9e-24 83.9 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG90897.1 - 1.4e-15 58.5 0.0 3.4e-15 57.3 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG90897.1 - 4.2e-10 39.5 0.1 1.6e-09 37.6 0.0 2.0 2 1 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 CRG90897.1 - 0.018 15.3 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain ADH_N_2 PF16884.5 CRG90897.1 - 0.092 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase FAD_binding_4 PF01565.23 CRG90898.1 - 4.7e-21 75.0 0.2 3.1e-20 72.3 0.2 2.2 1 1 0 1 1 1 1 FAD binding domain HA2 PF04408.23 CRG90899.1 - 1.4e-23 83.2 2.0 2.3e-23 82.5 0.0 2.4 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 CRG90899.1 - 5.1e-21 74.8 0.0 1.3e-20 73.6 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 CRG90899.1 - 5e-14 52.6 0.0 3.1e-13 50.0 0.0 2.4 3 0 0 3 3 2 1 Helicase conserved C-terminal domain S1 PF00575.23 CRG90899.1 - 2.1e-10 40.8 0.2 6e-10 39.3 0.2 1.8 1 0 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 CRG90899.1 - 4e-07 30.0 0.9 1e-06 28.6 0.9 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 CRG90899.1 - 7.9e-06 26.2 0.1 4e-05 23.9 0.1 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 CRG90899.1 - 0.0001 21.4 0.0 0.00029 20.0 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 CRG90899.1 - 0.00027 20.7 0.1 0.001 18.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 CRG90899.1 - 0.0085 16.4 0.2 0.02 15.2 0.2 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CRG90899.1 - 0.017 15.2 0.4 0.15 12.1 0.4 2.2 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 CRG90899.1 - 0.019 14.2 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 CRG90899.1 - 0.029 14.5 0.0 0.077 13.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 CRG90899.1 - 0.057 13.9 0.4 1.2 9.6 0.1 2.9 1 1 1 2 2 2 0 ABC transporter AAA_16 PF13191.6 CRG90899.1 - 0.065 13.6 0.0 0.21 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 CRG90899.1 - 0.067 12.6 0.1 0.19 11.2 0.1 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_7 PF12775.7 CRG90899.1 - 0.069 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 CRG90899.1 - 0.12 12.8 1.0 0.41 11.1 0.4 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 CRG90899.1 - 0.12 11.9 0.7 0.33 10.5 0.7 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ABC2_membrane PF01061.24 CRG90900.1 - 8e-77 257.4 40.9 7.2e-45 153.0 14.0 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 CRG90900.1 - 2.6e-40 138.1 0.0 4.5e-19 69.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CRG90900.1 - 6.3e-22 77.3 15.2 4e-21 74.7 0.2 4.3 5 0 0 5 5 5 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 CRG90900.1 - 1.6e-09 37.4 24.3 2.8e-09 36.6 1.5 3.1 2 1 1 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 CRG90900.1 - 2.6e-07 31.2 0.1 0.00032 21.1 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 CRG90900.1 - 1.3e-05 25.2 0.0 0.097 12.5 0.0 3.3 2 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 CRG90900.1 - 1.7e-05 24.8 0.0 0.00044 20.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 CRG90900.1 - 0.00017 21.1 0.0 0.043 13.2 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG90900.1 - 0.00049 19.8 0.2 0.028 14.1 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CRG90900.1 - 0.0019 18.5 0.0 0.23 11.7 0.0 3.4 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.6 CRG90900.1 - 0.004 17.7 0.0 0.24 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 CRG90900.1 - 0.01 15.9 0.0 5.7 7.1 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 CRG90900.1 - 0.014 15.3 0.2 0.63 9.9 0.1 2.7 3 0 0 3 3 3 0 NACHT domain cobW PF02492.19 CRG90900.1 - 0.032 13.8 0.1 0.7 9.4 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 CRG90900.1 - 0.032 13.8 0.1 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CRG90900.1 - 0.038 14.2 0.0 0.38 11.0 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CRG90900.1 - 0.064 13.4 0.0 0.42 10.8 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 CRG90900.1 - 0.079 12.7 0.0 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 CRG90900.1 - 0.15 11.8 0.0 3.2 7.5 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 CRG90900.1 - 0.17 12.4 0.0 0.4 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CRG90900.1 - 0.19 11.0 0.1 2 7.7 0.1 2.1 2 0 0 2 2 2 0 Zeta toxin HEAT_EZ PF13513.6 CRG90901.1 - 4.3e-21 75.0 6.1 2.9e-07 30.8 0.0 9.2 9 1 1 10 10 10 3 HEAT-like repeat HEAT PF02985.22 CRG90901.1 - 8.9e-20 69.1 0.1 0.00023 21.1 0.0 10.0 10 1 0 10 10 9 3 HEAT repeat HEAT_2 PF13646.6 CRG90901.1 - 2.1e-17 63.3 1.3 0.0019 18.6 0.0 7.8 7 1 1 8 8 8 3 HEAT repeats Cnd1 PF12717.7 CRG90901.1 - 7.3e-11 42.4 8.0 0.00089 19.3 0.0 5.5 3 2 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 CRG90901.1 - 2.9e-09 37.4 0.0 0.26 11.9 0.0 5.9 6 1 1 7 7 6 2 Vacuolar 14 Fab1-binding region ParcG PF10274.9 CRG90901.1 - 8.2e-09 35.8 2.3 0.0049 17.0 0.1 4.6 3 2 2 5 5 5 3 Parkin co-regulated protein IBN_N PF03810.19 CRG90901.1 - 5.5e-08 32.6 0.3 9.9e-07 28.6 0.0 2.9 2 0 0 2 2 2 1 Importin-beta N-terminal domain RTP1_C1 PF10363.9 CRG90901.1 - 1.4e-06 28.5 3.2 2.8 8.2 0.4 6.7 6 1 0 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_C PF12460.8 CRG90901.1 - 8e-06 25.2 0.1 2.7 7.0 0.2 3.9 3 1 1 4 4 4 3 RNAPII transcription regulator C-terminal UNC45-central PF11701.8 CRG90901.1 - 5.7e-05 23.1 0.3 0.042 13.8 0.2 3.7 2 1 1 4 4 4 1 Myosin-binding striated muscle assembly central Adaptin_N PF01602.20 CRG90901.1 - 0.00064 18.4 0.0 3.1 6.2 0.0 3.8 3 2 0 3 3 3 2 Adaptin N terminal region CLASP_N PF12348.8 CRG90901.1 - 0.0011 18.6 0.0 0.27 10.8 0.0 3.6 3 0 0 3 3 3 1 CLASP N terminal Tti2 PF10521.9 CRG90901.1 - 0.0015 18.1 0.1 1.1 8.8 0.0 4.3 4 1 1 5 5 5 1 Tti2 family RIX1 PF08167.12 CRG90901.1 - 0.0061 16.3 0.0 1.3 8.8 0.0 3.2 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Neurochondrin PF05536.11 CRG90901.1 - 0.024 13.0 2.2 0.096 11.0 0.7 2.2 2 0 0 2 2 2 0 Neurochondrin Rif1_N PF12231.8 CRG90901.1 - 0.078 12.0 0.1 20 4.0 0.1 3.5 3 2 1 4 4 4 0 Rap1-interacting factor 1 N terminal ERO1 PF04137.15 CRG90901.1 - 0.11 11.7 0.0 0.24 10.6 0.0 1.5 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Arm PF00514.23 CRG90901.1 - 0.21 11.7 0.4 46 4.2 0.0 4.5 4 0 0 4 4 3 0 Armadillo/beta-catenin-like repeat NPC1_N PF16414.5 CRG90902.1 - 1.4e-83 280.2 4.9 2.1e-83 279.7 4.9 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 CRG90902.1 - 5.1e-76 256.4 10.0 4.3e-75 253.4 10.0 1.9 1 1 0 1 1 1 1 Patched family Sterol-sensing PF12349.8 CRG90902.1 - 2.4e-52 176.8 6.7 2.4e-52 176.8 6.7 3.1 3 1 0 3 3 3 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 CRG90902.1 - 5.2e-05 22.3 29.5 9.4e-05 21.5 13.3 3.1 2 1 0 2 2 2 2 MMPL family Folate_rec PF03024.14 CRG90902.1 - 0.08 12.8 2.4 0.15 11.9 2.4 1.4 1 0 0 1 1 1 0 Folate receptor family REV1_C PF16727.5 CRG90902.1 - 0.15 12.5 0.0 0.32 11.4 0.0 1.5 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain ACR_tran PF00873.19 CRG90902.1 - 1.9 6.1 16.5 0.057 11.1 7.1 2.1 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family Amino_oxidase PF01593.24 CRG90903.1 - 5e-10 39.3 0.1 1.8e-09 37.4 0.1 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 CRG90903.1 - 2e-09 37.3 1.9 1.6e-08 34.3 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG90903.1 - 6.8e-08 32.6 0.1 6.8e-08 32.6 0.1 2.5 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG90903.1 - 2.4e-05 23.3 0.1 3.5e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 CRG90903.1 - 6.2e-05 22.7 0.1 0.00013 21.6 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG90903.1 - 0.00017 20.8 0.2 0.00017 20.8 0.2 2.1 3 0 0 3 3 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG90903.1 - 0.00081 18.7 0.2 0.0016 17.7 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 CRG90903.1 - 0.0032 17.1 0.3 0.0068 16.1 0.3 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 CRG90903.1 - 0.009 16.6 0.1 0.075 13.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG90903.1 - 0.025 13.8 0.0 0.044 13.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family GIDA PF01134.22 CRG90903.1 - 0.038 13.1 0.1 0.063 12.4 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CRG90903.1 - 0.069 12.4 0.2 0.19 10.9 0.1 1.7 2 0 0 2 2 2 0 FAD binding domain adh_short_C2 PF13561.6 CRG90904.1 - 2.3e-45 155.0 0.1 3e-45 154.6 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG90904.1 - 2.6e-34 118.4 0.4 3.6e-34 117.9 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG90904.1 - 9e-07 29.0 0.1 1.5e-06 28.3 0.1 1.3 1 0 0 1 1 1 1 KR domain AMP-binding PF00501.28 CRG90905.1 - 0 1625.3 0.0 2.1e-80 270.4 0.0 7.2 7 0 0 7 7 7 7 AMP-binding enzyme Condensation PF00668.20 CRG90905.1 - 0 1121.9 16.9 4.1e-44 151.0 0.0 13.6 12 2 0 12 12 12 12 Condensation domain PP-binding PF00550.25 CRG90905.1 - 1.8e-83 274.9 10.5 2.4e-12 47.0 0.0 8.4 8 0 0 8 8 8 7 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG90905.1 - 6.4e-21 75.1 0.2 0.11 13.5 0.0 7.8 7 0 0 7 7 7 6 AMP-binding enzyme C-terminal domain Transferase PF02458.15 CRG90905.1 - 0.026 13.2 0.0 9.1 4.8 0.0 4.6 6 0 0 6 6 6 0 Transferase family WES_acyltransf PF03007.16 CRG90905.1 - 0.064 13.0 0.0 5.6 6.7 0.0 3.2 3 0 0 3 3 3 0 Wax ester synthase-like Acyl-CoA acyltransferase domain NmrA PF05368.13 CRG90906.1 - 5.2e-05 22.9 0.0 0.0001 22.0 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG90906.1 - 0.001 19.0 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding SET PF00856.28 CRG90907.1 - 0.0055 17.1 0.0 0.0064 16.9 0.0 1.2 1 0 0 1 1 1 1 SET domain YbjQ_1 PF01906.17 CRG90908.1 - 3.9e-31 107.8 2.1 4.6e-31 107.5 2.1 1.1 1 0 0 1 1 1 1 Putative heavy-metal-binding F-box PF00646.33 CRG90909.1 - 0.079 12.9 0.3 0.18 11.7 0.3 1.6 1 0 0 1 1 1 0 F-box domain PAPS_reduct PF01507.19 CRG90910.1 - 0.57 10.2 2.3 1.1 9.3 2.3 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Tudor_3 PF18115.1 CRG90911.1 - 1.4e-07 31.3 0.0 2.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 CRG90911.1 - 4.1e-06 26.8 0.0 6.9e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) SMN PF06003.12 CRG90911.1 - 4.8e-05 22.8 2.2 0.00011 21.5 1.8 1.8 1 1 1 2 2 2 1 Survival motor neuron protein (SMN) DUF1325 PF07039.11 CRG90911.1 - 0.0013 18.8 0.1 0.0025 17.9 0.1 1.5 1 0 0 1 1 1 1 SGF29 tudor-like domain TUDOR PF00567.24 CRG90911.1 - 0.0061 16.6 0.0 0.046 13.7 0.0 2.0 2 0 0 2 2 2 1 Tudor domain Agenet PF05641.12 CRG90911.1 - 0.015 15.7 0.0 0.031 14.8 0.0 1.5 1 0 0 1 1 1 0 Agenet domain LBR_tudor PF09465.10 CRG90911.1 - 0.024 14.4 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain Tudor_2 PF18104.1 CRG90911.1 - 0.14 11.9 0.0 0.35 10.6 0.0 1.7 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain PAP1 PF08601.10 CRG90912.1 - 6.6e-117 391.4 25.3 6.6e-117 391.4 25.3 3.7 3 1 0 3 3 3 1 Transcription factor PAP1 bZIP_1 PF00170.21 CRG90912.1 - 4e-09 36.4 12.4 9.6e-09 35.2 12.4 1.6 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 CRG90912.1 - 0.0022 17.8 4.0 0.005 16.6 4.0 1.6 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 SlyX PF04102.12 CRG90912.1 - 0.005 17.4 0.6 0.013 16.1 0.6 1.7 1 0 0 1 1 1 1 SlyX bZIP_Maf PF03131.17 CRG90912.1 - 0.048 14.2 11.0 0.14 12.7 11.0 1.8 1 0 0 1 1 1 0 bZIP Maf transcription factor JIP_LZII PF16471.5 CRG90912.1 - 0.12 12.5 6.6 9.4 6.5 4.9 2.4 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF16 PF01519.16 CRG90912.1 - 0.14 12.7 4.8 0.045 14.2 1.7 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 Fmp27_WPPW PF10359.9 CRG90912.1 - 0.14 11.0 4.6 0.23 10.2 4.6 1.5 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF5320 PF17253.2 CRG90912.1 - 0.17 13.0 1.2 0.47 11.5 1.2 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5320) EMP24_GP25L PF01105.24 CRG90912.1 - 0.23 11.4 0.8 0.43 10.5 0.8 1.4 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD TolA_bind_tri PF16331.5 CRG90912.1 - 0.27 11.3 6.4 0.11 12.5 3.1 2.1 2 0 0 2 2 2 0 TolA binding protein trimerisation Mg_chelatase_C PF13335.6 CRG90912.1 - 0.61 10.7 3.5 1.5 9.5 3.5 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal bZIP_2 PF07716.15 CRG90912.1 - 0.67 10.1 19.3 0.46 10.6 15.1 2.7 2 1 1 3 3 3 0 Basic region leucine zipper CDC45 PF02724.14 CRG90912.1 - 2.4 6.4 7.8 4.9 5.3 7.8 1.5 1 0 0 1 1 1 0 CDC45-like protein DivIC PF04977.15 CRG90912.1 - 3 7.7 7.1 0.29 10.9 1.8 2.1 2 0 0 2 2 2 0 Septum formation initiator UPF0242 PF06785.11 CRG90912.1 - 3.3 7.8 8.2 6.6 6.8 8.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Phage_Nu1 PF07471.12 CRG90912.1 - 3.9 7.2 7.5 16 5.2 7.5 1.9 1 1 0 1 1 1 0 Phage DNA packaging protein Nu1 DUF2433 PF10360.9 CRG90913.1 - 2.2e-48 163.4 0.0 3.7e-48 162.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) Metallophos_2 PF12850.7 CRG90913.1 - 0.00012 22.3 0.0 0.00048 20.4 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 CRG90913.1 - 0.0026 18.3 0.0 0.0051 17.3 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase TRAUB PF08164.12 CRG90914.1 - 2.3e-31 108.1 1.7 4.5e-31 107.2 0.3 2.3 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 CRG90914.1 - 1.6e-25 90.4 3.0 1.6e-25 90.4 3.0 3.0 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor ParA PF10609.9 CRG90915.1 - 6.4e-84 281.2 0.0 2.4e-83 279.4 0.0 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 CRG90915.1 - 2.2e-13 50.4 0.0 6.6e-10 39.1 0.0 2.1 2 0 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 CRG90915.1 - 2e-09 37.6 0.3 1.8e-08 34.5 0.3 2.0 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 CRG90915.1 - 2.5e-06 27.0 0.0 3.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 CRG90915.1 - 0.00017 20.9 0.5 0.0022 17.3 0.4 2.4 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_25 PF13481.6 CRG90915.1 - 0.00067 19.3 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 CRG90915.1 - 0.0094 15.4 0.0 0.046 13.2 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Ribosomal_S27e PF01667.17 CRG90915.1 - 0.014 15.1 0.3 0.026 14.2 0.3 1.3 1 0 0 1 1 1 0 Ribosomal protein S27 CBP_BcsQ PF06564.12 CRG90915.1 - 0.099 12.1 0.1 0.26 10.7 0.1 1.7 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ VirC1 PF07015.11 CRG90915.1 - 0.11 11.8 0.1 0.17 11.2 0.1 1.2 1 0 0 1 1 1 0 VirC1 protein MeaB PF03308.16 CRG90915.1 - 0.12 11.3 0.3 0.2 10.6 0.3 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zn_Tnp_IS1595 PF12760.7 CRG90915.1 - 0.12 12.3 0.3 0.28 11.2 0.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain AAA_26 PF13500.6 CRG90915.1 - 0.19 11.6 0.2 2.3 8.0 0.4 2.0 2 0 0 2 2 2 0 AAA domain Abhydrolase_3 PF07859.13 CRG90916.1 - 1.8e-31 109.7 0.0 2.3e-20 73.3 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG90916.1 - 1.1e-11 44.2 0.0 3.2e-11 42.7 0.0 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase ADH_zinc_N_2 PF13602.6 CRG90917.1 - 9.3e-26 91.4 0.0 1.5e-25 90.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG90917.1 - 5.6e-14 52.2 0.0 9.6e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG90917.1 - 1.4e-07 31.4 1.0 1.9e-06 27.7 0.1 2.7 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 CRG90917.1 - 0.077 12.3 2.8 0.13 11.5 2.5 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MFS_1 PF07690.16 CRG90919.1 - 7.3e-27 94.2 36.7 2.4e-23 82.7 14.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FtsH_ext PF06480.15 CRG90919.1 - 0.018 15.4 0.3 0.081 13.3 0.1 2.2 2 0 0 2 2 2 0 FtsH Extracellular FMO-like PF00743.19 CRG90920.1 - 7.4e-43 146.8 0.0 2.1e-21 75.9 0.1 3.0 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG90920.1 - 2.6e-18 66.3 0.1 5.8e-12 45.5 0.0 3.1 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG90920.1 - 7.8e-13 48.3 0.0 4.6e-12 45.8 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90920.1 - 5.2e-11 42.8 0.0 1.9e-10 40.9 0.0 1.9 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CRG90920.1 - 1.2e-08 34.5 0.0 3.1e-06 26.6 0.0 2.7 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 CRG90920.1 - 3.7e-08 33.5 0.0 1.1e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG90920.1 - 1.2e-07 31.6 0.0 0.0015 18.2 0.0 2.8 3 0 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 CRG90920.1 - 2.4e-06 27.0 0.0 0.00048 19.4 0.0 2.3 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 CRG90920.1 - 0.0084 14.9 0.6 0.1 11.3 0.2 2.2 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 CRG90920.1 - 0.0097 15.2 0.0 0.1 11.8 0.0 2.3 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CRG90920.1 - 0.011 16.3 0.1 0.23 12.0 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG90920.1 - 0.016 14.5 0.0 0.044 13.0 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Shikimate_DH PF01488.20 CRG90920.1 - 0.024 14.7 0.1 2.6 8.1 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Glu_dehyd_C PF16912.5 CRG90920.1 - 0.11 11.9 0.0 0.95 8.9 0.0 2.3 3 0 0 3 3 3 0 Glucose dehydrogenase C-terminus MCRA PF06100.11 CRG90920.1 - 0.16 10.7 0.1 0.38 9.5 0.0 1.6 2 0 0 2 2 2 0 MCRA family DJ-1_PfpI PF01965.24 CRG90920.1 - 0.2 11.5 0.0 18 5.1 0.0 2.3 2 0 0 2 2 2 0 DJ-1/PfpI family Lycopene_cycl PF05834.12 CRG90920.1 - 0.22 10.5 0.0 0.62 9.1 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein Fungal_trans PF04082.18 CRG90921.1 - 3.2e-19 69.0 0.0 5.7e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG90921.1 - 8e-06 25.9 9.7 1.3e-05 25.2 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M19 PF01244.21 CRG90922.1 - 5.6e-72 242.6 0.0 6.8e-72 242.3 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) MFS_1 PF07690.16 CRG90923.1 - 2.4e-18 66.2 54.3 2.1e-15 56.5 50.3 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG90923.1 - 6.9e-08 31.4 23.0 9.5e-08 30.9 23.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pox_A14 PF05767.12 CRG90923.1 - 5.6 7.2 14.1 0.035 14.3 2.5 3.1 3 1 1 4 4 4 0 Poxvirus virion envelope protein A14 Cu-oxidase_2 PF07731.14 CRG90924.1 - 2.4e-20 72.7 5.1 2e-18 66.4 3.2 3.8 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 CRG90924.1 - 2.2e-18 66.9 0.0 4.4e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 CRG90924.1 - 0.00033 20.7 0.0 0.0011 19.0 0.0 1.9 1 0 0 1 1 1 1 Multicopper oxidase Amidohydro_1 PF01979.20 CRG90925.1 - 2.3e-38 132.4 0.1 2.8e-38 132.1 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG90925.1 - 2e-10 40.7 0.4 3.1e-07 30.2 0.0 2.9 2 1 0 2 2 2 2 Amidohydrolase family Urocanase_C PF17392.2 CRG90925.1 - 0.0062 16.0 0.5 0.072 12.5 0.1 2.3 1 1 0 2 2 2 1 Urocanase C-terminal domain Iso_dh PF00180.20 CRG90926.1 - 1.5e-102 343.3 0.0 1.8e-102 343.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase SesA PF17107.5 CRG90927.1 - 0.01 16.0 0.7 0.018 15.2 0.7 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF3605 PF12239.8 CRG90927.1 - 0.021 15.1 1.7 0.026 14.9 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3605) DUF1848 PF08902.11 CRG90927.1 - 0.077 12.7 1.2 0.1 12.3 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) DUF3987 PF13148.6 CRG90927.1 - 0.13 11.2 3.8 0.2 10.7 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) peroxidase PF00141.23 CRG90928.1 - 3.5e-45 154.5 0.0 5e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Peroxidase Epimerase PF01370.21 CRG90930.1 - 5.2e-12 45.8 0.1 1.9e-09 37.4 0.1 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG90930.1 - 6.4e-08 32.4 0.4 9.3e-08 31.9 0.4 1.2 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CRG90930.1 - 5.2e-07 29.4 0.4 6.2e-06 25.8 0.2 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG90930.1 - 2.3e-06 27.6 0.2 3.5e-06 27.0 0.2 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG90930.1 - 1.1e-05 24.6 0.1 1.9e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 CRG90930.1 - 9.9e-05 21.6 0.1 0.00014 21.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein TrkA_N PF02254.18 CRG90930.1 - 0.0097 16.2 0.1 0.02 15.1 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_4 PF07993.12 CRG90930.1 - 0.01 15.0 0.1 0.055 12.6 0.0 2.0 1 1 1 2 2 2 0 Male sterility protein RmlD_sub_bind PF04321.17 CRG90930.1 - 0.015 14.4 0.1 0.029 13.5 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain KR PF08659.10 CRG90930.1 - 0.1 12.5 0.4 0.17 11.8 0.4 1.3 1 0 0 1 1 1 0 KR domain CFEM PF05730.11 CRG90931.1 - 4.7e-14 52.2 10.7 7.5e-14 51.6 10.7 1.2 1 0 0 1 1 1 1 CFEM domain TRP PF06011.12 CRG90932.1 - 3.2e-155 517.1 35.8 3.8e-155 516.8 35.8 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CRG90932.1 - 2.3e-33 115.5 0.2 3.6e-33 114.9 0.2 1.3 1 0 0 1 1 1 1 ML-like domain Choline_sulf_C PF12411.8 CRG90932.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Choline sulfatase enzyme C terminal 5_nucleotid_C PF02872.18 CRG90934.1 - 2.2e-38 132.0 0.0 7.7e-38 130.2 0.0 1.8 2 0 0 2 2 2 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 CRG90934.1 - 5.9e-06 26.9 0.1 1.1e-05 26.1 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Lin-8 PF03353.15 CRG90934.1 - 0.4 10.2 4.4 0.61 9.6 4.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PCI PF01399.27 CRG90935.1 - 0.0077 16.7 0.0 6.6 7.3 0.0 3.1 3 1 0 3 3 3 2 PCI domain FMO-like PF00743.19 CRG90936.1 - 1.3e-19 70.1 0.0 4.1e-19 68.4 0.0 1.8 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG90936.1 - 6.5e-13 48.6 0.0 3.2e-09 36.5 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG90936.1 - 6.4e-11 42.0 0.0 2.2e-08 33.7 0.1 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG90936.1 - 8.8e-09 34.9 0.0 1.8e-05 24.1 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CRG90936.1 - 4.5e-07 30.3 0.6 0.02 15.4 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG90936.1 - 2.5e-06 27.6 0.3 3e-05 24.2 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain AlaDh_PNT_C PF01262.21 CRG90936.1 - 8.1e-06 25.3 0.0 0.02 14.2 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_9 PF13454.6 CRG90936.1 - 0.00063 19.8 0.7 0.067 13.2 0.1 3.2 4 0 0 4 4 3 1 FAD-NAD(P)-binding DAO PF01266.24 CRG90936.1 - 0.001 18.7 2.2 0.0049 16.5 0.3 2.5 4 0 0 4 4 4 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 CRG90936.1 - 0.0046 17.0 0.0 1.9 8.5 0.0 2.6 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 CRG90936.1 - 0.0064 16.4 0.1 0.0099 15.8 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 CRG90936.1 - 0.0074 15.0 0.5 0.78 8.4 0.0 2.9 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.6 CRG90936.1 - 0.011 16.1 0.0 0.072 13.5 0.0 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 CRG90936.1 - 1.1 8.2 3.3 0.41 9.7 0.2 1.7 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 CRG90936.1 - 3 6.8 3.7 1.3 8.1 0.2 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A TRAM_LAG1_CLN8 PF03798.16 CRG90937.1 - 2.1e-36 125.5 19.4 2.1e-36 125.5 19.4 2.0 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 CRG90937.1 - 1.7e-23 82.0 0.2 1.7e-23 82.0 0.2 1.9 2 0 0 2 2 2 1 TRAM1-like protein LpxC PF03331.13 CRG90937.1 - 0.19 11.2 0.0 0.66 9.4 0.0 1.8 2 0 0 2 2 2 0 UDP-3-O-acyl N-acetylglycosamine deacetylase Glyco_hydro_30 PF02055.16 CRG90938.1 - 2.4e-32 112.3 4.4 3.5e-32 111.7 4.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 CRG90938.1 - 1.1e-06 28.1 3.5 3.3e-06 26.5 3.5 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 59 Glyco_hydro_30C PF17189.4 CRG90938.1 - 1.6e-06 28.2 0.5 4e-06 26.9 0.5 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain SLAC1 PF03595.17 CRG90939.1 - 3.6e-56 190.8 41.1 4.1e-56 190.6 41.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel DUF3007 PF11460.8 CRG90939.1 - 4.3 7.6 8.6 3.3 8.0 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) Arrestin_N PF00339.29 CRG90940.1 - 7.4e-09 35.8 0.0 6.1e-08 32.8 0.0 2.0 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Guanylate_kin PF00625.21 CRG90941.1 - 6.9e-58 195.3 0.0 9.5e-58 194.9 0.0 1.2 1 0 0 1 1 1 1 Guanylate kinase Hva1_TUDOR PF11160.8 CRG90941.1 - 7.2e-05 22.9 1.2 0.0002 21.5 0.5 2.1 2 0 0 2 2 2 1 Hypervirulence associated proteins TUDOR domain MMR_HSR1 PF01926.23 CRG90941.1 - 0.0039 17.3 0.0 0.0091 16.1 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 CRG90941.1 - 0.011 16.2 0.0 0.026 14.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 CRG90941.1 - 0.011 16.2 0.2 0.053 14.1 0.2 2.2 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 CRG90941.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 CRG90941.1 - 0.014 15.5 0.0 0.05 13.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 CRG90941.1 - 0.024 14.6 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_5 PF07728.14 CRG90941.1 - 0.038 14.0 0.0 0.15 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 CRG90941.1 - 0.11 12.4 0.0 0.61 10.0 0.0 2.1 2 0 0 2 2 2 0 NTPase AAA_22 PF13401.6 CRG90941.1 - 0.16 12.2 0.0 0.43 10.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain adh_short_C2 PF13561.6 CRG90942.1 - 2.7e-51 174.4 0.1 3.6e-51 174.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG90942.1 - 1.3e-43 148.7 0.2 1.6e-43 148.5 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG90942.1 - 1.8e-11 44.3 0.2 2.5e-11 43.8 0.2 1.2 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 CRG90942.1 - 0.0013 18.2 0.1 0.0016 17.9 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CRG90942.1 - 0.0024 17.4 0.2 0.0053 16.3 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family HATPase_c PF02518.26 CRG90942.1 - 0.051 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ig_mannosidase PF17753.1 CRG90943.1 - 2.8e-24 84.7 0.2 7.3e-24 83.3 0.2 1.8 1 0 0 1 1 1 1 Ig-fold domain Mannosidase_ig PF17786.1 CRG90943.1 - 1.9e-11 44.4 0.0 7.5e-11 42.5 0.0 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CRG90943.1 - 1e-05 26.2 0.0 2.7e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 CRG90943.1 - 0.078 12.1 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Aminotran_1_2 PF00155.21 CRG90944.1 - 8.6e-35 120.6 0.0 1.2e-34 120.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CRG90944.1 - 1.4e-07 31.1 0.0 2.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CRG90944.1 - 5.2e-06 25.7 0.0 8.8e-06 24.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 CRG90944.1 - 6e-06 25.0 0.0 9.9e-06 24.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme OKR_DC_1 PF01276.20 CRG90944.1 - 0.0057 15.4 0.0 0.025 13.3 0.0 1.8 1 1 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Pyr_redox_3 PF13738.6 CRG90945.1 - 2.6e-11 43.3 0.0 4.5e-08 32.7 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG90945.1 - 1.8e-09 37.3 0.0 2.1e-08 33.7 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CRG90945.1 - 4.6e-09 35.2 0.0 3.4e-08 32.4 0.0 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG90945.1 - 9.7e-09 35.3 0.0 6e-07 29.6 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG90945.1 - 2.7e-08 33.3 0.0 1.5e-05 24.3 0.0 2.3 2 0 0 2 2 2 2 Thi4 family Lycopene_cycl PF05834.12 CRG90945.1 - 1.2e-05 24.6 0.1 0.0089 15.1 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_2 PF00890.24 CRG90945.1 - 1.3e-05 24.5 0.0 0.0017 17.5 0.0 3.1 3 0 0 3 3 3 1 FAD binding domain DAO PF01266.24 CRG90945.1 - 5.8e-05 22.8 1.7 0.0021 17.7 0.0 3.4 2 1 1 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CRG90945.1 - 0.00015 21.1 0.1 0.0016 17.6 0.0 2.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CRG90945.1 - 0.004 17.7 0.0 0.67 10.6 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 CRG90945.1 - 0.0063 16.6 0.0 0.26 11.3 0.0 2.7 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase Amino_oxidase PF01593.24 CRG90945.1 - 0.0093 15.3 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase GIDA PF01134.22 CRG90945.1 - 0.023 13.8 0.0 0.056 12.5 0.0 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 CRG90945.1 - 0.041 14.3 0.0 0.21 12.1 0.0 2.1 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 CRG90945.1 - 0.083 12.2 0.1 0.17 11.2 0.1 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Zn_clus PF00172.18 CRG90946.1 - 1.2e-07 31.7 5.4 2.4e-07 30.8 5.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ketoacyl-synt PF00109.26 CRG90947.1 - 3.6e-71 239.7 0.0 7e-71 238.8 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG90947.1 - 9.1e-62 208.2 0.0 2e-61 207.0 0.0 1.7 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CRG90947.1 - 9e-53 179.4 0.0 1.4e-52 178.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG90947.1 - 7.4e-43 147.2 0.9 2.8e-42 145.4 0.2 2.1 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG90947.1 - 2.5e-35 121.0 0.0 7.5e-35 119.5 0.0 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG90947.1 - 2.3e-22 80.5 0.0 9.8e-20 72.0 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 CRG90947.1 - 3.7e-20 72.5 0.0 1.2e-19 70.9 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG90947.1 - 8.6e-18 64.8 0.1 9.7e-17 61.4 0.1 2.6 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CRG90947.1 - 1.5e-16 60.5 0.2 1.5e-15 57.4 0.1 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 CRG90947.1 - 3.9e-11 43.1 0.0 8e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG90947.1 - 3.6e-10 40.4 0.0 1.4e-09 38.5 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90947.1 - 2e-09 38.0 0.0 7.4e-09 36.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 CRG90947.1 - 2.3e-07 30.7 0.2 5.8e-07 29.4 0.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.18 CRG90947.1 - 3.9e-07 29.7 0.0 8.8e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family adh_short PF00106.25 CRG90947.1 - 1.1e-06 28.3 0.0 3.2e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CRG90947.1 - 1.4e-05 25.3 0.1 5.8e-05 23.4 0.1 2.1 2 0 0 2 2 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 CRG90947.1 - 1.5e-05 24.8 0.0 3.4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CRG90947.1 - 0.0028 17.0 0.0 0.006 16.0 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain PCMT PF01135.19 CRG90947.1 - 0.026 14.3 0.1 0.62 9.8 0.0 2.5 2 1 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_33 PF10017.9 CRG90947.1 - 0.043 13.0 0.0 0.14 11.3 0.0 1.8 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent FSH1 PF03959.13 CRG90948.1 - 4.9e-25 88.4 0.0 8.1e-25 87.7 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) FAD_binding_3 PF01494.19 CRG90949.1 - 1.2e-22 80.7 0.1 2.7e-16 59.8 0.0 3.0 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG90949.1 - 6.5e-06 26.3 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG90949.1 - 0.001 18.4 0.0 0.011 14.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG90949.1 - 0.0095 15.0 0.1 0.2 10.6 0.0 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 CRG90949.1 - 0.025 14.6 0.2 0.081 12.9 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 CRG90949.1 - 0.041 13.5 0.0 0.089 12.4 0.0 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 CRG90949.1 - 0.065 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Semialdhyde_dh PF01118.24 CRG90949.1 - 0.15 12.5 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain MFS_1 PF07690.16 CRG90950.1 - 7.3e-42 143.5 45.3 1.2e-40 139.6 41.6 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG90950.1 - 9.5e-14 50.7 16.2 9.5e-14 50.7 16.2 2.5 1 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG90950.1 - 6.3e-06 25.3 16.4 6.3e-06 25.3 16.4 2.5 3 0 0 3 3 3 1 Sugar (and other) transporter DUF3185 PF11381.8 CRG90950.1 - 0.0029 17.6 1.8 0.0029 17.6 1.8 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3185) MFS_1_like PF12832.7 CRG90950.1 - 0.0033 16.3 10.6 0.0033 16.3 10.6 2.4 2 2 0 2 2 2 1 MFS_1 like family DUF543 PF04418.12 CRG90950.1 - 5.7 7.0 6.4 8.2 6.5 0.1 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF543) UDPGT PF00201.18 CRG90951.1 - 4.9e-21 75.1 0.0 9.8e-21 74.1 0.0 1.4 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 CRG90951.1 - 0.044 13.7 0.0 0.12 12.3 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain NolV PF06635.12 CRG90951.1 - 0.085 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein NolV Aa_trans PF01490.18 CRG90952.1 - 6.4e-54 183.2 40.3 7.3e-54 183.0 40.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Lipase_GDSL_2 PF13472.6 CRG90953.1 - 4.8e-13 49.9 1.7 6.7e-13 49.4 1.7 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG90953.1 - 1.6e-07 31.5 0.2 2.6e-07 30.8 0.2 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SASA PF03629.18 CRG90953.1 - 0.16 11.6 0.0 1.2 8.7 0.0 2.2 1 1 0 1 1 1 0 Carbohydrate esterase, sialic acid-specific acetylesterase Glyco_hydro_76 PF03663.14 CRG90954.1 - 2.7e-121 405.5 24.5 3.3e-121 405.2 24.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 2OG-FeII_Oxy PF03171.20 CRG90955.1 - 2.2e-11 44.2 0.0 4.3e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG90955.1 - 0.058 14.1 0.1 0.58 10.9 0.1 2.1 1 1 1 2 2 2 0 non-haem dioxygenase in morphine synthesis N-terminal NAD_binding_10 PF13460.6 CRG90956.1 - 1.9e-09 37.7 0.1 2.7e-09 37.2 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG90956.1 - 6.5e-09 35.6 0.1 1.8e-08 34.1 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG90956.1 - 1.7e-08 33.8 0.0 2.4e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG90956.1 - 5.1e-07 29.1 1.2 2.4e-05 23.7 1.2 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 CRG90956.1 - 9e-07 28.7 0.0 2.2e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CRG90956.1 - 1.1e-06 28.3 0.0 1.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase SusE PF14292.6 CRG90956.1 - 0.0064 16.7 1.4 0.012 15.9 1.4 1.4 1 0 0 1 1 1 1 SusE outer membrane protein KR PF08659.10 CRG90956.1 - 0.013 15.4 0.8 0.22 11.4 0.8 2.1 1 1 0 1 1 1 0 KR domain Polysacc_synt_2 PF02719.15 CRG90956.1 - 0.018 14.2 0.0 0.031 13.4 0.0 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein ArabFuran-catal PF09206.11 CRG90957.1 - 1.8e-142 474.3 14.6 2.4e-142 473.9 14.6 1.1 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic AbfB PF05270.13 CRG90957.1 - 2.3e-53 180.0 0.1 3.6e-53 179.3 0.1 1.3 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B (ABFB) domain Fungal_trans PF04082.18 CRG90958.1 - 1.6e-18 66.7 0.0 2.5e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG90959.1 - 4.1e-27 95.0 33.6 1.4e-18 67.0 23.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG90959.1 - 1.5e-12 47.2 12.2 1.5e-12 47.2 12.2 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter AMP-binding PF00501.28 CRG90960.1 - 9.1e-77 258.4 0.0 1.3e-76 257.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 CRG90960.1 - 5.5e-59 199.4 0.0 1.4e-58 198.1 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein adh_short PF00106.25 CRG90960.1 - 2.3e-53 180.6 1.6 4.3e-53 179.7 1.6 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90960.1 - 2.9e-39 135.0 0.5 5.1e-39 134.2 0.5 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90960.1 - 1.4e-17 64.2 2.4 3.4e-14 53.2 1.3 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 CRG90960.1 - 2.6e-15 56.5 0.0 2.2e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 CRG90960.1 - 4.4e-11 43.0 0.0 1.1e-10 41.7 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 CRG90960.1 - 2.1e-07 30.2 0.1 0.00015 20.9 0.0 2.9 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CRG90960.1 - 3.2e-07 29.7 0.8 4.6e-05 22.7 0.1 2.8 2 1 0 2 2 2 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 CRG90960.1 - 2.4e-06 27.6 0.2 1.4e-05 25.1 0.2 2.3 2 0 0 2 2 2 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 CRG90960.1 - 2e-05 23.9 0.4 0.081 12.0 0.3 2.8 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein AMP-binding_C PF13193.6 CRG90960.1 - 0.0035 18.3 0.0 0.014 16.3 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GDP_Man_Dehyd PF16363.5 CRG90960.1 - 0.016 14.6 0.0 3.3 7.0 0.0 2.5 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase ApbA PF02558.16 CRG90960.1 - 0.05 13.2 0.2 0.11 12.1 0.2 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.19 CRG90960.1 - 0.15 11.3 0.2 0.44 9.8 0.2 1.8 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_32N PF00251.20 CRG90961.1 - 2.8e-40 138.8 4.4 2.7e-39 135.6 4.4 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 CRG90961.1 - 8.4e-33 113.6 0.0 1.3e-32 113.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal DUF4975 PF16346.5 CRG90961.1 - 5e-08 33.2 0.2 1e-07 32.2 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4975) BNR PF02012.20 CRG90961.1 - 0.018 14.9 0.3 0.073 13.1 0.3 2.1 1 0 0 1 1 1 0 BNR/Asp-box repeat CHB_HEX_C PF03174.13 CRG90961.1 - 0.16 12.0 0.1 0.46 10.5 0.1 1.8 1 0 0 1 1 1 0 Chitobiase/beta-hexosaminidase C-terminal domain MiAMP1 PF09117.10 CRG90962.1 - 4.4e-05 23.6 2.2 0.01 16.1 0.6 2.1 2 0 0 2 2 2 2 MiAMP1 Glyco_hydro_28 PF00295.17 CRG90963.1 - 3e-09 36.4 0.1 0.00047 19.3 0.0 2.5 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CRG90963.1 - 2.6e-08 34.0 7.6 2.6e-07 30.7 5.8 2.8 1 1 1 2 2 2 1 Pectate lyase superfamily protein Fucose_iso_N1 PF07881.12 CRG90963.1 - 0.062 13.2 0.4 3.1 7.6 0.0 2.4 2 0 0 2 2 2 0 L-fucose isomerase, first N-terminal domain Retrotrans_gag PF03732.17 CRG90965.1 - 4e-06 27.0 0.1 7.1e-06 26.2 0.1 1.4 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.5 CRG90965.1 - 1.9e-05 24.5 0.0 2.6e-05 24.0 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4939) Carn_acyltransf PF00755.20 CRG90967.1 - 1.9e-105 353.7 0.1 3.7e-80 270.2 0.0 2.2 1 1 1 2 2 2 2 Choline/Carnitine o-acyltransferase ketoacyl-synt PF00109.26 CRG90967.1 - 1e-76 257.9 0.0 1.9e-76 257.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG90967.1 - 4.9e-53 180.3 0.0 7.7e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase KR PF08659.10 CRG90967.1 - 7.7e-51 172.6 0.7 2e-50 171.2 0.3 2.0 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 CRG90967.1 - 4.4e-42 144.7 0.1 8.2e-42 143.8 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG90967.1 - 7.6e-37 125.9 0.1 7e-36 122.8 0.1 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 CRG90967.1 - 5e-14 52.2 0.0 1.7e-13 50.4 0.0 2.0 1 0 0 1 1 1 1 short chain dehydrogenase KAsynt_C_assoc PF16197.5 CRG90967.1 - 1.1e-13 51.7 0.0 3e-13 50.2 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CRG90967.1 - 3.3e-11 43.3 0.8 6.2e-09 35.9 0.1 4.0 4 0 0 4 4 4 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG90967.1 - 1.4e-09 39.1 0.0 1.3e-08 35.9 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 CRG90967.1 - 2.4e-07 31.4 0.0 1e-06 29.4 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 CRG90967.1 - 2.6e-07 30.9 0.3 6.2e-07 29.7 0.3 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 CRG90967.1 - 4.2e-07 29.8 0.1 9.5e-07 28.6 0.1 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_23 PF13489.6 CRG90967.1 - 3.3e-05 23.8 0.0 9.3e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CRG90967.1 - 0.00013 21.6 0.0 0.00027 20.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 CRG90967.1 - 0.00028 21.5 0.0 0.0042 17.8 0.0 3.0 2 0 0 2 2 2 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 CRG90967.1 - 0.00053 19.2 0.0 0.00093 18.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Thiolase_N PF00108.23 CRG90967.1 - 0.00087 18.7 0.1 0.0019 17.6 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 CRG90967.1 - 0.0016 19.1 0.0 0.0091 16.6 0.0 2.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG90967.1 - 0.0017 18.2 0.0 0.012 15.4 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain PALP PF00291.25 CRG90967.1 - 0.0034 16.8 0.9 0.13 11.7 0.0 2.9 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme GDP_Man_Dehyd PF16363.5 CRG90967.1 - 0.0047 16.4 0.0 0.0071 15.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Methyltransf_24 PF13578.6 CRG90967.1 - 0.014 16.4 0.1 0.71 10.9 0.0 3.8 4 0 0 4 4 2 0 Methyltransferase domain 3Beta_HSD PF01073.19 CRG90967.1 - 0.053 12.5 0.0 0.096 11.7 0.0 1.4 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family F420_oxidored PF03807.17 CRG90967.1 - 0.067 13.8 0.0 0.31 11.7 0.0 2.1 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent ADH_N PF08240.12 CRG90967.1 - 0.12 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Methyltransf_16 PF10294.9 CRG90967.1 - 0.16 11.7 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase MFS_1 PF07690.16 CRG90968.1 - 2.7e-32 112.1 52.3 2.7e-32 112.1 52.3 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily Ank_5 PF13857.6 CRG90969.1 - 2.7e-15 56.2 0.6 2.5e-07 30.8 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG90969.1 - 2.4e-12 47.2 0.0 3.9e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG90969.1 - 8.2e-12 45.4 0.1 2.7e-11 43.8 0.1 1.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG90969.1 - 9.2e-12 44.9 0.9 0.00014 22.1 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CRG90969.1 - 4.1e-11 42.1 0.1 0.00067 19.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat bZIP_2 PF07716.15 CRG90969.1 - 0.31 11.1 7.2 0.52 10.4 7.2 1.3 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_1 PF00170.21 CRG90969.1 - 0.69 10.1 7.2 1.2 9.3 7.2 1.2 1 0 0 1 1 1 0 bZIP transcription factor FA_desaturase PF00487.24 CRG90970.1 - 4.3e-24 85.7 9.3 7.7e-24 84.9 9.3 1.4 1 0 0 1 1 1 1 Fatty acid desaturase AMP-binding PF00501.28 CRG90971.1 - 2.6e-293 971.8 0.0 2.2e-79 267.1 0.0 5.4 4 1 0 4 4 4 4 AMP-binding enzyme Condensation PF00668.20 CRG90971.1 - 5.7e-241 799.9 12.9 6.9e-48 163.5 0.0 10.2 9 2 0 9 9 9 7 Condensation domain PP-binding PF00550.25 CRG90971.1 - 1.5e-44 150.1 7.4 9.2e-13 48.4 0.1 5.0 4 0 0 4 4 4 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG90971.1 - 2.4e-08 34.8 0.8 0.024 15.6 0.0 4.3 4 0 0 4 4 4 2 AMP-binding enzyme C-terminal domain Transferase PF02458.15 CRG90971.1 - 0.00013 20.8 0.1 1.5 7.4 0.0 4.5 5 0 0 5 5 5 2 Transferase family DUF3544 PF12064.8 CRG90971.1 - 0.095 13.0 0.1 0.47 10.7 0.0 2.2 2 0 0 2 2 2 0 Protein kinase C-binding protein 1 ketoacyl-synt PF00109.26 CRG90972.1 - 1.6e-65 221.2 0.0 4.1e-65 219.9 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG90972.1 - 1.6e-59 200.9 0.1 7.2e-59 198.7 0.1 2.3 1 0 0 1 1 1 1 KR domain PS-DH PF14765.6 CRG90972.1 - 2.6e-53 181.2 0.0 4e-53 180.6 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG90972.1 - 2.4e-44 152.2 0.2 4.6e-44 151.2 0.2 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG90972.1 - 9.5e-36 122.4 0.0 5.4e-35 120.0 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG90972.1 - 5e-19 68.9 0.0 2.6e-18 66.6 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CRG90972.1 - 1.4e-16 61.7 0.0 2e-14 54.8 0.0 3.1 2 1 1 3 3 3 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG90972.1 - 1.6e-16 60.5 0.7 9.9e-16 57.9 0.3 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 CRG90972.1 - 1.1e-13 51.6 0.1 4.1e-13 49.8 0.0 2.0 2 0 0 2 2 1 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 CRG90972.1 - 1.4e-11 44.2 0.4 1.5e-10 40.8 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_25 PF13649.6 CRG90972.1 - 2.5e-09 37.7 0.1 2e-08 34.8 0.0 2.8 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG90972.1 - 2.6e-08 33.9 0.0 1e-07 32.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG90972.1 - 6e-07 30.0 0.0 2e-05 25.1 0.0 2.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG90972.1 - 1.6e-05 24.4 0.0 0.00015 21.2 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family adh_short_C2 PF13561.6 CRG90972.1 - 1.9e-05 24.3 0.0 4.9e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CRG90972.1 - 6e-05 23.3 0.1 0.00015 22.0 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 CRG90972.1 - 0.00011 22.0 0.0 0.00029 20.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CRG90972.1 - 0.00058 19.3 0.0 0.0017 17.8 0.0 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_2 PF00891.18 CRG90972.1 - 0.0061 15.9 0.0 0.018 14.4 0.0 1.7 1 0 0 1 1 1 1 O-methyltransferase domain ADH_N PF08240.12 CRG90972.1 - 0.016 15.1 0.0 0.037 13.9 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Polysacc_synt_2 PF02719.15 CRG90972.1 - 0.045 12.9 0.0 0.077 12.1 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 CRG90972.1 - 0.091 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 CRG90972.1 - 0.12 11.8 0.0 0.25 10.8 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family PALP PF00291.25 CRG90972.1 - 2.9 7.2 6.2 0.25 10.7 0.3 2.0 2 0 0 2 2 2 0 Pyridoxal-phosphate dependent enzyme Aminotran_3 PF00202.21 CRG90974.1 - 5.6e-80 269.0 0.0 6.7e-80 268.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III ABC_tran PF00005.27 CRG90975.1 - 1.1e-34 119.9 0.0 8.7e-18 65.2 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG90975.1 - 1.4e-25 90.5 38.9 3.4e-23 82.7 15.4 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG90975.1 - 5.7e-09 35.7 0.2 5.2e-05 22.8 0.0 3.2 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG90975.1 - 0.00012 22.0 0.6 1.5 8.5 0.0 3.3 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CRG90975.1 - 0.018 15.3 0.6 4.1 7.7 0.1 3.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CRG90975.1 - 0.13 12.0 0.0 0.47 10.2 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain Kinocilin PF15033.6 CRG90975.1 - 0.54 9.9 4.1 8.2 6.1 0.2 2.9 2 0 0 2 2 2 0 Kinocilin protein MFS_1 PF07690.16 CRG90976.1 - 9.7e-17 60.9 34.7 3.3e-15 55.9 30.5 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 CRG90976.1 - 0.0012 17.3 0.5 0.0012 17.3 0.5 2.9 2 2 1 3 3 3 1 Transmembrane secretion effector PIP49_N PF14875.6 CRG90976.1 - 0.09 12.6 0.2 0.16 11.8 0.2 1.3 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 DUF3098 PF11297.8 CRG90976.1 - 1.6 8.4 4.9 0.46 10.1 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3098) Alk_phosphatase PF00245.20 CRG90977.1 - 1.3e-68 231.8 0.1 2.8e-68 230.8 0.1 1.5 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 CRG90977.1 - 1.2e-07 31.4 0.8 1.1e-06 28.3 0.8 2.2 1 1 0 1 1 1 1 Sulfatase DUF229 PF02995.17 CRG90977.1 - 0.00022 19.9 0.2 0.00037 19.2 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Metalloenzyme PF01676.18 CRG90977.1 - 0.00061 19.2 0.5 0.0012 18.2 0.2 1.6 2 0 0 2 2 2 1 Metalloenzyme superfamily Phosphodiest PF01663.22 CRG90977.1 - 0.00084 19.0 0.1 0.0013 18.4 0.1 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 CRG90977.1 - 0.071 12.2 0.1 0.11 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) ADP_ribosyl_GH PF03747.14 CRG90979.1 - 1e-15 58.2 0.0 1.2e-15 58.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase ABC_tran PF00005.27 CRG90980.1 - 1e-24 87.6 0.0 1.9e-24 86.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane PF01061.24 CRG90980.1 - 1.9e-14 53.6 7.1 1.9e-14 53.6 7.1 1.8 2 0 0 2 2 2 1 ABC-2 type transporter RsgA_GTPase PF03193.16 CRG90980.1 - 0.00051 20.0 0.5 0.0012 18.7 0.2 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 CRG90980.1 - 0.0087 15.9 0.1 0.032 14.0 0.0 1.8 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CRG90980.1 - 0.015 14.9 0.0 0.07 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 CRG90980.1 - 0.015 14.4 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CRG90980.1 - 0.034 14.2 0.1 0.062 13.4 0.1 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase SMC_N PF02463.19 CRG90980.1 - 0.052 13.0 0.5 0.54 9.7 0.3 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG90980.1 - 0.083 12.6 0.4 0.23 11.2 0.4 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CRG90980.1 - 0.095 13.1 0.0 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 CRG90980.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Dynamin family DUF87 PF01935.17 CRG90980.1 - 0.13 12.3 1.2 0.26 11.4 1.2 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain IIGP PF05049.13 CRG90980.1 - 0.26 10.3 0.4 0.41 9.6 0.4 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC2_membrane_3 PF12698.7 CRG90980.1 - 2.5 7.1 21.6 0.012 14.7 12.8 1.5 2 0 0 2 2 1 0 ABC-2 family transporter protein Sugar_tr PF00083.24 CRG90981.1 - 2.4e-91 306.9 25.2 3e-91 306.6 25.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG90981.1 - 4.7e-16 58.6 65.6 2.6e-14 53.0 31.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily PgaD PF13994.6 CRG90981.1 - 0.25 11.4 2.1 4.5 7.3 0.9 2.7 2 0 0 2 2 2 0 PgaD-like protein Glyco_hydro_2_C PF02836.17 CRG90982.1 - 2.8e-14 53.0 0.0 1.2e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 CRG90982.1 - 3.4e-14 53.1 0.2 1.2e-13 51.3 0.2 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 CRG90982.1 - 4e-12 46.8 1.0 6.6e-11 42.9 0.1 2.3 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 RAI16-like PF10257.9 CRG90982.1 - 0.045 12.6 0.0 0.062 12.2 0.0 1.1 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein Tape_meas_lam_C PF09718.10 CRG90983.1 - 0.047 13.8 0.1 0.1 12.8 0.1 1.5 1 0 0 1 1 1 0 Lambda phage tail tape-measure protein (Tape_meas_lam_C) PrpF PF04303.13 CRG90984.1 - 2.4e-94 316.3 0.1 2.9e-94 316.1 0.1 1.0 1 0 0 1 1 1 1 PrpF protein Pro_racemase PF05544.11 CRG90984.1 - 6.6e-06 25.4 0.5 0.043 12.9 0.0 2.2 2 0 0 2 2 2 2 Proline racemase Fungal_trans PF04082.18 CRG90985.1 - 5.3e-18 65.0 0.3 8.5e-18 64.3 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 CRG90986.1 - 6.2e-15 55.4 0.0 7.4e-15 55.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG90986.1 - 2.2e-05 24.0 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase MFS_1 PF07690.16 CRG90987.1 - 1.7e-25 89.7 25.5 1.5e-24 86.6 25.5 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG90987.1 - 2.9e-09 35.9 2.1 3.3e-09 35.7 2.1 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG90987.1 - 2.1e-07 30.2 11.3 3.9e-07 29.3 11.3 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter DUF1576 PF07613.11 CRG90987.1 - 0.0017 17.9 0.9 0.0017 17.9 0.9 2.6 2 1 1 3 3 3 1 Protein of unknown function (DUF1576) DUF3784 PF12650.7 CRG90987.1 - 0.64 10.2 6.5 0.98 9.7 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3784) DUF3995 PF13160.6 CRG90987.1 - 3 8.2 9.5 0.4 11.0 1.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3995) Fungal_trans PF04082.18 CRG90988.1 - 6.6e-13 48.3 0.2 6.6e-13 48.3 0.2 2.3 3 0 0 3 3 3 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG90988.1 - 3e-09 36.8 10.6 8.9e-05 22.7 1.0 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG90988.1 - 2e-06 28.0 12.7 2.5e-06 27.6 3.7 3.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG90988.1 - 6.6e-06 26.5 8.9 0.01 16.6 2.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 CRG90988.1 - 0.015 15.6 1.5 6 7.4 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CRG90988.1 - 0.25 11.4 6.0 1.1 9.3 1.3 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HE PF16278.5 CRG90988.1 - 0.31 11.5 5.4 0.67 10.4 1.6 2.6 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 CRG90988.1 - 0.34 11.2 1.8 0.75 10.1 1.8 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 CRG90988.1 - 3 7.8 6.5 0.41 10.6 1.0 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Transferase PF02458.15 CRG90989.1 - 5.1e-20 71.5 0.0 7.2e-20 71.0 0.0 1.3 1 1 0 1 1 1 1 Transferase family Hemerythrin PF01814.23 CRG90990.1 - 5.2e-08 33.6 0.1 7.3e-08 33.1 0.1 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF5132 PF17195.4 CRG90990.1 - 0.089 12.9 0.4 0.18 11.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF5132) AMP-binding PF00501.28 CRG90991.1 - 4.1e-101 338.6 0.0 5e-101 338.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG90991.1 - 4.1e-14 53.3 0.0 1e-13 52.0 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain K_oxygenase PF13434.6 CRG90992.1 - 2.4e-114 382.1 0.1 2.8e-114 381.8 0.1 1.0 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 CRG90992.1 - 2.1e-12 46.9 0.0 1.9e-09 37.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG90992.1 - 2.8e-12 46.5 0.1 4.2e-10 39.4 0.0 3.0 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG90992.1 - 5.6e-10 39.4 0.1 8.5e-06 25.8 0.0 3.2 2 1 1 3 3 3 2 FAD-NAD(P)-binding Pyr_redox PF00070.27 CRG90992.1 - 5.9e-05 23.6 0.0 0.0056 17.2 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CRG90992.1 - 0.0058 15.1 0.2 0.028 12.8 0.2 1.8 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG90992.1 - 0.036 14.3 0.0 1.4 9.2 0.0 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG90992.1 - 0.086 12.1 0.0 0.64 9.2 0.0 2.1 2 0 0 2 2 2 0 Thi4 family Acetyltransf_8 PF13523.6 CRG90993.1 - 1.4e-46 157.8 2.5 2.1e-46 157.2 2.5 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain MaoC_dehydratas PF01575.19 CRG90993.1 - 1.2e-19 70.1 0.0 2.7e-19 68.9 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CRG90993.1 - 0.00045 20.4 0.0 0.39 10.8 0.0 2.5 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Acetyltransf_3 PF13302.7 CRG90993.1 - 0.12 13.0 0.2 0.3 11.7 0.2 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pyr_redox_2 PF07992.14 CRG90994.1 - 2.5e-28 99.2 0.0 1e-26 93.9 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG90994.1 - 2.5e-11 44.0 1.7 2.5e-09 37.6 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG90994.1 - 1.9e-06 27.3 0.1 2.9e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG90994.1 - 2e-05 24.0 0.0 3.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG90994.1 - 0.0027 17.3 3.3 0.3 10.6 0.2 3.4 3 1 1 4 4 4 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG90994.1 - 0.0029 16.7 4.0 0.038 13.1 0.2 2.4 2 1 1 3 3 3 2 Lycopene cyclase protein NAD_binding_8 PF13450.6 CRG90994.1 - 0.067 13.4 0.0 0.36 11.1 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG90994.1 - 0.067 12.4 0.2 0.16 11.2 0.2 1.5 1 0 0 1 1 1 0 Thi4 family XdhC_C PF13478.6 CRG90994.1 - 0.076 13.5 0.0 1 9.9 0.0 2.2 2 0 0 2 2 2 0 XdhC Rossmann domain FAD_binding_3 PF01494.19 CRG90994.1 - 0.39 9.9 1.4 0.95 8.6 0.1 2.2 3 0 0 3 3 3 0 FAD binding domain Pectinesterase PF01095.19 CRG90995.1 - 4.7e-51 173.3 4.5 6.1e-51 172.9 4.5 1.0 1 0 0 1 1 1 1 Pectinesterase adh_short PF00106.25 CRG90996.1 - 4.8e-22 78.4 0.0 7.3e-18 64.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90996.1 - 3.4e-14 53.0 0.1 1.5e-09 37.8 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90996.1 - 1.3e-11 44.7 0.2 2.4e-11 43.9 0.1 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG90996.1 - 7.2e-06 25.6 0.0 9.9e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 CRG90996.1 - 0.0022 17.2 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Amidohydro_2 PF04909.14 CRG90996.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.7 1 1 0 1 1 1 0 Amidohydrolase NAD_binding_10 PF13460.6 CRG90996.1 - 0.13 12.1 0.0 0.32 10.9 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H-binding adh_short PF00106.25 CRG90997.1 - 3.7e-41 140.7 3.0 6.1e-41 140.0 2.8 1.5 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG90997.1 - 2e-29 102.8 4.0 5.6e-29 101.3 4.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG90997.1 - 8.1e-10 38.9 1.2 1.2e-09 38.4 1.2 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG90997.1 - 4.1e-08 32.9 0.1 1.3e-07 31.3 0.1 1.6 1 1 1 2 2 2 1 Fungal family of unknown function (DUF1776) NmrA PF05368.13 CRG90997.1 - 1.3e-06 28.2 0.1 2.4e-06 27.3 0.1 1.5 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG90997.1 - 2.2e-06 27.7 0.2 3.3e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG90997.1 - 7.1e-06 25.6 0.3 2.4e-05 23.9 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 CRG90997.1 - 0.00012 22.3 0.1 0.00031 21.0 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG90997.1 - 0.00088 19.5 0.3 0.002 18.4 0.2 1.5 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 CRG90997.1 - 0.0033 18.0 0.1 0.0097 16.5 0.1 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DFP PF04127.15 CRG90997.1 - 0.0036 17.1 0.5 0.0057 16.5 0.5 1.3 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein ADH_zinc_N PF00107.26 CRG90997.1 - 0.0039 17.2 0.5 0.01 15.8 0.3 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase RmlD_sub_bind PF04321.17 CRG90997.1 - 0.017 14.3 0.3 0.042 12.9 0.1 1.7 2 0 0 2 2 2 0 RmlD substrate binding domain ApbA PF02558.16 CRG90997.1 - 0.052 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_binding_10 PF13460.6 CRG90998.1 - 1.1e-30 106.9 0.0 1.2e-30 106.7 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG90998.1 - 1.6e-08 34.3 0.0 2.3e-08 33.8 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG90998.1 - 3.3e-05 23.6 0.3 0.00013 21.7 0.1 1.9 2 0 0 2 2 2 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CRG90998.1 - 0.0014 18.1 0.0 0.0029 17.1 0.0 1.5 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase ELFV_dehydrog PF00208.21 CRG90998.1 - 0.0094 15.7 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase PAC2 PF09754.9 CRG90998.1 - 0.01 15.9 0.0 0.02 14.9 0.0 1.5 1 1 0 1 1 1 0 PAC2 family DapB_N PF01113.20 CRG90998.1 - 0.029 14.5 0.1 0.05 13.7 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus TrkA_N PF02254.18 CRG90998.1 - 0.14 12.4 0.0 0.31 11.3 0.0 1.6 1 1 0 1 1 1 0 TrkA-N domain Zn_clus PF00172.18 CRG90999.1 - 9e-10 38.5 9.7 9e-10 38.5 9.7 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AflR PF08493.10 CRG90999.1 - 0.0012 18.3 23.0 0.0059 16.1 23.0 2.4 2 1 0 2 2 2 1 Aflatoxin regulatory protein Mito_carr PF00153.27 CRG91000.1 - 2.4e-51 171.6 7.1 2.2e-18 65.9 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Fungal_trans_2 PF11951.8 CRG91000.1 - 0.00064 18.6 3.2 0.0012 17.7 3.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Serine_protease PF18405.1 CRG91000.1 - 0.15 11.2 4.2 1.2 8.3 0.1 2.7 2 1 1 3 3 3 0 Gammaproteobacterial serine protease BNR_2 PF13088.6 CRG91001.1 - 2.5e-21 76.2 1.2 3.1e-12 46.4 0.1 2.2 1 1 1 2 2 2 2 BNR repeat-like domain BNR_3 PF13859.6 CRG91001.1 - 2.8e-06 26.9 1.4 4.3e-05 22.9 0.1 2.1 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 CRG91001.1 - 0.00011 21.7 32.8 0.11 12.5 0.6 6.3 5 0 0 5 5 5 4 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 CRG91001.1 - 0.00052 18.9 10.4 0.17 10.7 2.3 3.6 2 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, CyRPA PF18638.1 CRG91001.1 - 0.013 14.7 7.5 2.3 7.3 0.1 4.6 3 1 2 5 5 5 0 Cysteine-Rich Protective Antigen 6 bladed domain BNR_4 PF15892.5 CRG91001.1 - 0.048 13.0 1.5 0.37 10.1 1.1 2.2 1 1 1 2 2 2 0 BNR repeat-containing family member SAPI PF16560.5 CRG91001.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Putative mobile pathogenicity island SpaA PF17802.1 CRG91001.1 - 1.5 9.2 5.6 4.4 7.7 0.4 3.2 3 1 0 3 3 3 0 Prealbumin-like fold domain Carboxyl_trans PF01039.22 CRG91002.1 - 7.6e-80 268.9 0.0 9.6e-80 268.6 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 CRG91003.1 - 4.8e-43 147.1 0.1 1.9e-40 138.6 0.1 2.3 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 CRG91003.1 - 5.4e-28 97.2 0.0 1.1e-27 96.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 CRG91003.1 - 3.6e-25 88.7 0.0 7.9e-25 87.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 CRG91003.1 - 4.4e-10 39.3 1.4 1.5e-09 37.5 0.3 2.4 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 CRG91003.1 - 2.9e-07 30.2 0.1 2.3e-06 27.3 0.0 2.0 1 1 1 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 CRG91003.1 - 0.00024 21.2 0.0 0.0017 18.4 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 CRG91003.1 - 0.0018 17.9 0.0 0.014 15.0 0.0 2.1 1 1 1 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 CRG91003.1 - 0.0074 16.0 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.6 CRG91003.1 - 0.035 13.9 0.6 0.095 12.5 0.0 2.0 2 0 0 2 2 2 0 Biotin-lipoyl like RnfC_N PF13375.6 CRG91003.1 - 0.038 14.0 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain ATPgrasp_ST PF14397.6 CRG91003.1 - 0.082 12.1 0.0 0.45 9.7 0.0 1.9 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp adh_short PF00106.25 CRG91004.1 - 2.2e-34 118.6 0.0 2.8e-34 118.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91004.1 - 1.1e-24 87.3 0.0 1.4e-24 86.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91004.1 - 2e-06 27.8 0.1 5.6e-06 26.4 0.1 1.7 1 1 0 1 1 1 1 KR domain Lipoprotein_3 PF00938.17 CRG91004.1 - 0.0087 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 Lipoprotein 3HCDH_N PF02737.18 CRG91004.1 - 0.0093 15.9 0.1 0.018 14.9 0.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 CRG91004.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Fungal_trans_2 PF11951.8 CRG91006.1 - 0.00034 19.5 0.6 0.00053 18.9 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 CRG91007.1 - 4.9e-36 124.4 28.0 5.1e-36 124.3 24.3 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4491 PF14898.6 CRG91007.1 - 0.21 12.1 0.3 0.21 12.1 0.3 3.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4491) Asp PF00026.23 CRG91008.1 - 8.2e-70 235.7 1.8 1e-69 235.4 1.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG91008.1 - 1.2e-10 41.9 3.1 2.5e-09 37.6 3.1 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG91008.1 - 0.00012 22.6 0.5 2.9 8.6 0.1 3.9 3 2 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 CRG91008.1 - 0.032 14.0 0.0 0.68 9.7 0.0 2.3 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal P33MONOX PF15302.6 CRG91008.1 - 0.088 12.5 2.2 0.14 11.8 2.2 1.2 1 0 0 1 1 1 0 P33 mono-oxygenase TPT PF03151.16 CRG91009.1 - 1e-21 77.6 21.1 1e-21 77.6 21.1 1.4 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.20 CRG91009.1 - 0.00032 20.9 37.7 0.00036 20.7 16.1 3.0 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 CRG91009.1 - 0.0035 16.6 22.0 0.015 14.5 22.0 1.9 1 1 0 1 1 1 1 UAA transporter family Glyco_transf_34 PF05637.12 CRG91010.1 - 3.3e-11 43.4 1.8 2.9e-10 40.3 1.8 1.9 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 CRG91010.1 - 5.8e-08 33.0 1.6 1.3e-07 31.8 0.9 1.9 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase Glyco_hydro_31 PF01055.26 CRG91011.1 - 4e-147 491.0 4.5 5.1e-147 490.6 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG91011.1 - 1.8e-34 118.4 0.2 3.1e-34 117.6 0.2 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG91011.1 - 1.5e-08 34.8 0.1 4e-08 33.5 0.1 1.8 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 CRG91011.1 - 0.0036 17.5 0.1 0.011 15.9 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) adh_short_C2 PF13561.6 CRG91012.1 - 0.0032 17.1 0.0 0.0045 16.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Sugar_tr PF00083.24 CRG91013.1 - 1.5e-08 34.0 1.2 3.2e-06 26.3 0.1 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter ATP-grasp_3 PF02655.14 CRG91014.1 - 0.021 14.8 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 ATP-grasp domain Pro-kuma_activ PF09286.11 CRG91015.1 - 1e-47 162.0 0.0 1.7e-47 161.3 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 CRG91015.1 - 0.012 14.9 0.0 0.035 13.4 0.0 1.7 1 1 0 1 1 1 0 Subtilase family Na_H_Exchanger PF00999.21 CRG91016.1 - 8.9e-45 153.1 47.2 1.1e-43 149.5 46.7 2.3 2 1 0 2 2 2 1 Sodium/hydrogen exchanger family Bmp PF02608.14 CRG91016.1 - 0.2 10.6 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like Usp PF00582.26 CRG91016.1 - 0.22 12.0 1.0 1.5 9.3 0.8 2.3 2 1 0 2 2 2 0 Universal stress protein family Fungal_trans_2 PF11951.8 CRG91017.1 - 2.1e-09 36.7 0.0 3.3e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_76 PF03663.14 CRG91018.1 - 6.8e-129 430.5 18.4 8.5e-129 430.2 18.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CRG91018.1 - 0.0032 16.6 9.3 0.35 9.9 0.7 3.1 2 1 1 3 3 3 2 Glycosyl Hydrolase Family 88 DUF1180 PF06679.12 CRG91018.1 - 0.55 10.6 1.7 1 9.8 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Epimerase PF01370.21 CRG91019.1 - 4.1e-18 65.7 0.1 5.6e-18 65.3 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG91019.1 - 9.1e-08 32.2 0.3 1.2e-07 31.9 0.3 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG91019.1 - 5.6e-07 29.3 0.3 0.0026 17.2 0.0 2.5 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CRG91019.1 - 9.3e-07 28.6 0.1 1.6e-06 27.9 0.1 1.4 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 CRG91019.1 - 3.2e-06 26.3 0.0 5e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CRG91019.1 - 4.4e-06 26.0 0.1 6.4e-06 25.5 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG91019.1 - 0.0025 17.0 0.1 1.5 7.9 0.0 2.4 1 1 1 2 2 2 2 Male sterility protein ADH_zinc_N PF00107.26 CRG91019.1 - 0.07 13.1 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Zinc-binding dehydrogenase DUF4874 PF16173.5 CRG91020.1 - 3.5e-10 39.8 0.0 5.1e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4874) DUF4832 PF16116.5 CRG91020.1 - 0.016 15.1 0.1 0.023 14.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4832) adh_short_C2 PF13561.6 CRG91021.1 - 1.2e-49 169.0 0.0 1.4e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91021.1 - 2.3e-43 147.9 0.0 2.8e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase DUF1776 PF08643.10 CRG91021.1 - 2.5e-05 23.8 0.0 3.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 CRG91021.1 - 0.0008 19.4 0.1 0.0013 18.6 0.1 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 CRG91021.1 - 0.009 15.9 0.0 0.048 13.5 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 CRG91021.1 - 0.015 14.7 0.0 0.024 14.1 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CRG91021.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain MFS_1 PF07690.16 CRG91022.1 - 1.1e-38 133.0 33.0 4.1e-38 131.2 33.0 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91022.1 - 9e-17 61.1 20.0 2.4e-14 53.0 4.4 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter DUF697 PF05128.12 CRG91022.1 - 0.029 14.1 0.3 0.083 12.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF697) OATP PF03137.20 CRG91022.1 - 2.1 6.5 8.8 0.23 9.7 0.6 2.3 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Glyco_hydro_106 PF17132.4 CRG91023.1 - 2.5e-29 102.2 0.1 1.4e-26 93.0 0.2 2.1 2 0 0 2 2 2 2 alpha-L-rhamnosidase Glyco_hydro_2_N PF02837.18 CRG91023.1 - 0.00015 21.7 0.0 0.00044 20.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain DUF4988 PF16378.5 CRG91023.1 - 0.1 12.3 0.1 0.95 9.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function Tannase PF07519.11 CRG91024.1 - 2.7e-90 303.5 0.0 3.2e-90 303.3 0.0 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Abhydrolase_1 PF00561.20 CRG91024.1 - 0.029 14.0 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Corona_NSP4_C PF16348.5 CRG91024.1 - 0.045 14.6 0.3 6.5 7.6 0.1 2.4 2 0 0 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus COesterase PF00135.28 CRG91025.1 - 6.6e-80 269.4 0.0 1.2e-79 268.5 0.0 1.4 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG91025.1 - 3.1e-05 23.9 0.0 0.00024 21.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 CRG91026.1 - 1.5e-39 136.1 0.0 1.8e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG91026.1 - 6.6e-06 25.8 0.0 8.6e-05 22.1 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family BAAT_C PF08840.11 CRG91026.1 - 0.00078 19.4 0.0 0.0012 18.8 0.0 1.3 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 CRG91026.1 - 0.00086 18.9 0.0 0.054 13.0 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Say1_Mug180 PF10340.9 CRG91026.1 - 0.0012 17.8 0.0 0.0016 17.4 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Chlorophyllase2 PF12740.7 CRG91026.1 - 0.0043 16.0 0.0 0.025 13.5 0.0 1.9 2 0 0 2 2 2 1 Chlorophyllase enzyme Peptidase_S15 PF02129.18 CRG91026.1 - 0.005 16.5 0.0 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase_phd PF10503.9 CRG91026.1 - 0.0086 15.6 0.1 0.023 14.2 0.0 1.7 2 0 0 2 2 2 1 Esterase PHB depolymerase AXE1 PF05448.12 CRG91026.1 - 0.029 13.0 0.0 0.051 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF2974 PF11187.8 CRG91026.1 - 0.032 13.8 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Thioesterase PF00975.20 CRG91026.1 - 0.04 14.0 0.0 0.071 13.2 0.0 1.5 1 1 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 CRG91026.1 - 0.042 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_2 PF02230.16 CRG91026.1 - 0.24 11.2 0.0 0.36 10.6 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Glyco_hydro_3_C PF01915.22 CRG91027.1 - 7.2e-41 140.4 0.0 2.9e-40 138.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG91027.1 - 1.5e-35 123.1 0.0 3.4e-35 121.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG91027.1 - 2.6e-18 65.9 0.1 4.8e-18 65.0 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Epimerase PF01370.21 CRG91028.1 - 1.4e-22 80.4 0.2 5.7e-22 78.4 0.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG91028.1 - 6.6e-15 55.3 0.1 3e-13 49.9 0.1 2.3 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CRG91028.1 - 2.6e-10 39.8 0.1 5.1e-10 38.8 0.1 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG91028.1 - 6.4e-08 32.7 0.0 1.5e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 CRG91028.1 - 4.7e-07 29.2 0.0 9.2e-07 28.2 0.0 1.4 2 0 0 2 2 2 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG91028.1 - 4.8e-07 29.2 0.1 0.00078 18.7 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CRG91028.1 - 7.6e-07 28.5 1.7 4.1e-05 22.9 0.9 2.6 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NmrA PF05368.13 CRG91028.1 - 0.00021 21.0 0.6 0.002 17.7 0.6 2.1 1 1 0 1 1 1 1 NmrA-like family KR PF08659.10 CRG91028.1 - 0.016 15.1 0.5 0.12 12.2 0.5 2.2 1 1 0 1 1 1 0 KR domain adh_short PF00106.25 CRG91028.1 - 0.043 13.3 0.1 0.09 12.2 0.1 1.7 1 1 0 1 1 1 0 short chain dehydrogenase PTR2 PF00854.21 CRG91029.1 - 0.019 13.8 3.3 0.023 13.5 3.3 1.3 1 1 0 1 1 1 0 POT family Glyco_hydro_3 PF00933.21 CRG91030.1 - 3.2e-44 151.6 0.0 5.7e-44 150.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CRG91030.1 - 6.4e-41 140.5 0.0 2e-40 138.9 0.0 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 CRG91030.1 - 1.4e-06 28.3 0.1 1.4e-05 25.1 0.0 2.8 3 0 0 3 3 3 1 Fibronectin type III-like domain Zn_clus PF00172.18 CRG91031.1 - 5.7e-07 29.5 15.4 1.3e-05 25.2 11.1 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 CRG91032.1 - 9.8e-71 238.9 23.4 1.1e-70 238.7 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91032.1 - 1.9e-18 66.5 24.2 1.9e-18 66.5 24.2 2.6 1 1 2 3 3 3 2 Major Facilitator Superfamily Bac_rhamnosid6H PF17389.2 CRG91033.1 - 5.4e-114 381.0 0.0 7e-114 380.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_N PF08531.10 CRG91033.1 - 2.9e-50 170.4 0.0 2.7e-49 167.3 0.0 2.2 2 0 0 2 2 2 1 Alpha-L-rhamnosidase N-terminal domain Bac_rhamnosid PF05592.11 CRG91033.1 - 6.7e-27 93.5 0.0 1.3e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase concanavalin-like domain Bac_rhamnosid_C PF17390.2 CRG91033.1 - 1.4e-22 79.3 0.0 3.2e-22 78.1 0.0 1.7 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain Polyketide_cyc2 PF10604.9 CRG91034.1 - 0.0057 16.9 0.0 0.011 16.0 0.0 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport TehB PF03848.14 CRG91034.1 - 0.19 11.1 0.0 0.3 10.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Pectate_lyase_3 PF12708.7 CRG91035.1 - 2e-88 295.8 34.5 2.4e-80 269.4 12.0 3.8 4 1 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CRG91035.1 - 3.2e-08 33.1 2.9 0.002 17.8 0.4 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase ADH_N PF08240.12 CRG91036.1 - 3.7e-26 91.1 0.6 7e-26 90.3 0.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG91036.1 - 2.2e-12 47.1 0.0 4.6e-10 39.6 0.0 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG91036.1 - 0.088 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 CRG91037.1 - 1.6e-19 70.3 0.0 3.5e-11 43.0 0.1 3.0 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 CRG91037.1 - 0.0041 17.3 0.0 0.0098 16.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Acetyltransf_2 PF00797.17 CRG91038.1 - 1.5e-37 129.7 0.0 1.9e-37 129.3 0.0 1.1 1 0 0 1 1 1 1 N-acetyltransferase Transglut_core PF01841.19 CRG91038.1 - 0.031 14.7 0.1 0.066 13.7 0.0 1.7 2 0 0 2 2 2 0 Transglutaminase-like superfamily ABC2_membrane PF01061.24 CRG91039.1 - 2.4e-83 278.7 58.7 4e-46 157.1 22.8 2.6 3 0 0 3 3 2 2 ABC-2 type transporter ABC_tran PF00005.27 CRG91039.1 - 1.5e-39 135.7 0.0 1.7e-18 67.5 0.0 3.4 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CRG91039.1 - 2.7e-33 113.7 5.8 3e-28 97.6 0.0 3.4 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 CRG91039.1 - 1.2e-18 67.5 0.2 3.5e-18 66.0 0.2 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 CRG91039.1 - 5.7e-07 29.3 0.1 2.8e-05 23.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CRG91039.1 - 2.7e-06 27.9 0.1 0.013 15.9 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 CRG91039.1 - 5.1e-05 23.2 0.1 0.0038 17.2 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 CRG91039.1 - 5.9e-05 23.3 0.0 0.082 13.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 CRG91039.1 - 0.00014 22.4 0.0 0.11 13.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CRG91039.1 - 0.00025 20.7 0.7 0.027 14.2 0.2 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 CRG91039.1 - 0.00063 19.6 0.0 1.6 8.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG91039.1 - 0.00098 18.6 0.0 0.38 10.1 0.0 3.6 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 CRG91039.1 - 0.0025 18.3 0.4 0.81 10.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain Mem_trans PF03547.18 CRG91039.1 - 0.0064 14.9 0.0 0.0093 14.4 0.0 1.4 1 0 0 1 1 1 1 Membrane transport protein NACHT PF05729.12 CRG91039.1 - 0.011 15.6 0.3 3.3 7.6 0.2 2.7 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 CRG91039.1 - 0.023 15.0 0.3 2.5 8.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CRG91039.1 - 0.034 13.7 0.8 0.74 9.4 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CRG91039.1 - 0.044 13.5 0.1 7.1 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 CRG91039.1 - 0.068 13.6 0.0 23 5.4 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC2_membrane_3 PF12698.7 CRG91039.1 - 0.085 12.0 42.7 0.03 13.4 18.1 2.9 2 1 0 2 2 2 0 ABC-2 family transporter protein AAA_30 PF13604.6 CRG91039.1 - 0.13 11.9 2.0 2.7 7.7 0.4 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 CRG91039.1 - 0.18 12.3 0.1 1.2 9.6 0.0 2.3 3 0 0 3 3 2 0 AAA domain TRI12 PF06609.13 CRG91040.1 - 7.3e-23 80.8 2.9 8.4e-23 80.6 2.9 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3040 PF11239.8 CRG91040.1 - 4.2 7.7 6.0 1.7 9.0 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Alginate_lyase2 PF08787.11 CRG91041.1 - 1.1e-37 130.2 0.1 2.2e-37 129.2 0.1 1.4 1 0 0 1 1 1 1 Alginate lyase Abhydrolase_6 PF12697.7 CRG91041.1 - 8.7e-14 52.7 0.5 1.4e-12 48.7 0.5 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG91041.1 - 6.1e-12 45.7 0.0 2.2e-11 43.9 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG91041.1 - 3.2e-05 23.3 0.0 8.1e-05 22.0 0.0 1.7 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CRG91041.1 - 0.036 13.5 0.0 0.074 12.5 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 CRG91041.1 - 0.13 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Na_Ca_ex PF01699.24 CRG91042.1 - 1.2e-31 109.8 29.9 2e-18 66.8 12.5 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Aminotran_4 PF01063.19 CRG91043.1 - 3.5e-24 85.9 0.0 4.7e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Cytokin_check_N PF10407.9 CRG91044.1 - 0.018 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus IF-2B PF01008.17 CRG91045.1 - 5.1e-17 62.0 0.2 6.9e-12 45.2 0.0 2.1 2 0 0 2 2 2 2 Initiation factor 2 subunit family NUDIX PF00293.28 CRG91045.1 - 2.9e-07 30.6 0.1 6.5e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 NUDIX domain DUF262 PF03235.14 CRG91045.1 - 0.12 12.5 0.1 0.45 10.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF262 Ribonuc_2-5A PF06479.12 CRG91047.1 - 8.5e-40 135.9 0.0 1.5e-39 135.1 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 CRG91047.1 - 1.9e-39 135.6 0.0 2.4e-28 99.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91047.1 - 2.3e-20 73.0 0.0 2.6e-19 69.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 CRG91047.1 - 4.7e-05 23.1 0.0 0.089 12.8 0.0 2.9 2 0 0 2 2 2 2 PQQ enzyme repeat Kdo PF06293.14 CRG91047.1 - 0.02 14.2 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CRG91047.1 - 0.024 13.4 0.0 0.058 12.2 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase PQQ_2 PF13360.6 CRG91047.1 - 0.058 13.0 0.0 0.15 11.6 0.0 1.7 1 1 0 1 1 1 0 PQQ-like domain Glyco_hydro_76 PF03663.14 CRG91048.1 - 1.2e-138 462.7 26.6 1.7e-138 462.1 26.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Nucleoporin_FG PF13634.6 CRG91049.1 - 0.007 17.2 80.9 0.15 13.0 16.8 4.9 2 1 3 5 5 5 3 Nucleoporin FG repeat region ELYS PF13934.6 CRG91050.1 - 1.9e-65 220.9 0.6 2.4e-65 220.6 0.6 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly SMC_N PF02463.19 CRG91051.1 - 4.4e-71 238.8 16.7 2.1e-70 236.6 16.7 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 CRG91051.1 - 6.4e-23 81.3 0.0 2e-22 79.7 0.0 2.0 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 CRG91051.1 - 1.8e-10 41.1 6.0 6.1e-05 23.0 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 CRG91051.1 - 0.00011 21.8 0.0 0.00072 19.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain Cob_adeno_trans PF01923.18 CRG91051.1 - 0.0049 17.0 4.0 0.0049 17.0 4.0 6.3 2 2 3 6 6 6 1 Cobalamin adenosyltransferase ABC_tran PF00005.27 CRG91051.1 - 1.9 9.0 0.0 1.9 9.0 0.0 6.1 5 3 1 6 6 6 0 ABC transporter UvsW PF11637.8 CRG91051.1 - 7.1 6.8 9.2 2.2 8.4 1.3 4.3 4 0 0 4 4 4 0 ATP-dependant DNA helicase UvsW Sugar_tr PF00083.24 CRG91052.1 - 1.5e-98 330.6 19.2 1.8e-98 330.4 19.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91052.1 - 2.6e-18 66.1 32.1 6.2e-17 61.6 27.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Ribosomal_S10 PF00338.22 CRG91053.1 - 6.9e-26 90.3 0.7 8.1e-26 90.1 0.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e CUE PF02845.16 CRG91054.1 - 1.9e-05 24.3 0.1 4.4e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 CUE domain Sec5 PF15469.6 CRG91054.1 - 0.062 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Exocyst complex component Sec5 Glyco_hydro_92 PF07971.12 CRG91055.1 - 1.1e-143 479.6 1.9 1.3e-143 479.3 1.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CRG91055.1 - 8.4e-48 163.3 4.5 1.3e-47 162.7 4.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DNA_binding_1 PF01035.20 CRG91055.1 - 2.3e-25 88.5 0.0 4.9e-25 87.5 0.0 1.6 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain zf-C2H2 PF00096.26 CRG91056.1 - 2.7e-05 24.4 7.7 0.0014 19.0 0.5 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG91056.1 - 0.0013 19.4 4.5 0.0035 18.0 0.5 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger Not3 PF04065.15 CRG91057.1 - 1.6e-85 286.3 20.1 2.4e-85 285.7 20.1 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 CRG91057.1 - 8.3e-45 152.1 10.5 2.1e-44 150.8 10.5 1.7 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 CRG91057.1 - 0.005 16.7 2.9 0.016 15.1 2.9 1.8 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) Sec5 PF15469.6 CRG91057.1 - 0.13 12.0 8.4 0.17 11.7 0.9 2.4 2 0 0 2 2 2 0 Exocyst complex component Sec5 PHM7_cyt PF14703.6 CRG91057.1 - 0.29 11.4 12.6 8.7 6.5 12.6 2.7 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter FlaC_arch PF05377.11 CRG91057.1 - 0.91 10.0 7.3 55 4.3 0.1 3.9 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Cep57_MT_bd PF06657.13 CRG91057.1 - 1 9.9 6.4 3 8.3 0.5 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 CENP-Q PF13094.6 CRG91057.1 - 1.8 8.7 11.5 0.52 10.5 8.1 1.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit SLATT_fungal PF18142.1 CRG91057.1 - 1.9 8.5 3.6 1.9 8.5 0.8 2.4 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain LPP PF04728.13 CRG91057.1 - 2.9 8.3 7.2 0.27 11.7 0.2 3.0 4 0 0 4 4 4 0 Lipoprotein leucine-zipper MCM3AP_GANP PF16769.5 CRG91057.1 - 6.9 4.8 13.7 0.33 9.1 8.1 1.6 2 0 0 2 2 2 0 MCM3AP domain of GANP Tyr_Deacylase PF02580.16 CRG91058.1 - 5.3e-51 172.9 1.0 8.8e-51 172.2 0.1 1.8 2 0 0 2 2 2 1 D-Tyr-tRNA(Tyr) deacylase Pro_isomerase PF00160.21 CRG91058.1 - 6.1e-48 163.1 0.8 1.1e-47 162.2 0.1 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 CRG91058.1 - 1.2e-06 28.1 2.8 0.00075 19.2 0.5 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG91058.1 - 2.4e-06 27.2 5.0 0.0023 17.9 1.4 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG91058.1 - 0.011 16.0 3.7 2.3 8.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 CRG91058.1 - 0.038 14.2 4.7 0.88 10.0 0.9 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 CRG91058.1 - 0.059 13.5 2.0 0.91 9.7 1.6 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG91058.1 - 0.1 13.4 10.9 0.079 13.8 2.8 4.2 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 CRG91058.1 - 0.23 11.2 4.2 8.8 6.1 0.2 3.2 3 0 0 3 3 3 0 TPR repeat TPR_6 PF13174.6 CRG91058.1 - 0.31 11.8 6.4 25 5.8 1.3 4.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG91058.1 - 1.3 9.7 15.9 3 8.6 7.8 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat FmdA_AmdA PF03069.15 CRG91059.1 - 2.2e-177 589.5 0.0 2.5e-177 589.3 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family EI24 PF07264.11 CRG91060.1 - 2.5e-14 53.9 0.4 1.4e-06 28.6 0.0 2.1 1 1 1 2 2 2 2 Etoposide-induced protein 2.4 (EI24) DUF4112 PF13430.6 CRG91060.1 - 0.027 14.7 0.3 1.8 8.9 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4112) DUF3742 PF12553.8 CRG91060.1 - 0.38 10.9 1.7 0.41 10.8 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) DUF3487 PF11990.8 CRG91060.1 - 3.2 7.6 0.0 3.2 7.6 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3487) Inp1 PF12634.7 CRG91061.1 - 1.2e-36 125.7 0.0 2.7e-36 124.6 0.0 1.6 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 SRP14 PF02290.15 CRG91062.1 - 3e-25 88.4 0.0 3e-25 88.4 0.0 1.6 2 0 0 2 2 2 1 Signal recognition particle 14kD protein Me-amine-dh_L PF02975.14 CRG91062.1 - 0.16 12.5 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Methylamine dehydrogenase, L chain Cytomega_UL20A PF05984.12 CRG91062.1 - 0.18 12.1 3.4 2.8 8.3 0.4 2.1 1 1 1 2 2 2 0 Cytomegalovirus UL20A protein MIF4G PF02854.19 CRG91063.1 - 1.1e-21 77.5 1.2 2.3e-21 76.4 0.6 1.9 2 0 0 2 2 2 1 MIF4G domain MA3 PF02847.17 CRG91063.1 - 3.2e-19 69.0 0.0 8.3e-19 67.6 0.0 1.8 1 0 0 1 1 1 1 MA3 domain Histone PF00125.24 CRG91063.1 - 0.25 11.7 0.0 0.25 11.7 0.0 3.3 4 1 1 5 5 5 0 Core histone H2A/H2B/H3/H4 COPI_C PF06957.11 CRG91063.1 - 5 5.8 14.2 0.026 13.3 5.2 1.7 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus SepRS_C PF18006.1 CRG91064.1 - 0.19 11.9 0.4 16 5.7 0.1 2.5 2 0 0 2 2 2 0 O-phosphoseryl-tRNA synthetase C-terminal domain Sugar_tr PF00083.24 CRG91065.1 - 1.2e-115 387.0 13.9 2.4e-115 386.0 13.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91065.1 - 5.8e-29 101.1 42.5 3.1e-24 85.6 21.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG91065.1 - 0.00043 18.8 4.2 0.00086 17.8 2.9 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Aldo_ket_red PF00248.21 CRG91066.1 - 3.9e-41 141.2 0.0 4.1e-39 134.5 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family adh_short_C2 PF13561.6 CRG91066.1 - 1.3e-13 51.1 0.0 2.7e-13 50.0 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91066.1 - 4.6e-13 49.1 0.2 1e-12 48.0 0.2 1.5 1 0 0 1 1 1 1 short chain dehydrogenase Cupin_2 PF07883.11 CRG91068.1 - 7.1e-07 28.9 0.1 1.2e-06 28.1 0.1 1.4 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 CRG91068.1 - 0.079 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Hydrolase_like PF13242.6 CRG91069.1 - 2.8e-05 24.1 0.0 0.0001 22.3 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 CRG91069.1 - 0.0016 18.7 0.0 0.0044 17.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 CRG91069.1 - 0.02 15.0 0.0 0.09 12.9 0.0 2.1 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase F-box-like PF12937.7 CRG91071.1 - 2.3e-05 24.2 0.1 5.1e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 F-box-like LMWPc PF01451.21 CRG91073.1 - 8e-33 113.8 0.0 9.6e-32 110.3 0.0 2.0 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase NTase_sub_bind PF08780.11 CRG91073.1 - 0.054 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like TPR_10 PF13374.6 CRG91074.1 - 0.15 12.0 0.1 0.47 10.4 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Sugar_tr PF00083.24 CRG91075.1 - 1.1e-82 278.4 20.8 1.2e-82 278.2 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91075.1 - 5.8e-18 64.9 30.9 7e-11 41.6 14.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4579 PF15158.6 CRG91075.1 - 0.83 9.4 2.9 4.7 6.9 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4579) Pectate_lyase_3 PF12708.7 CRG91076.1 - 5.9e-100 333.5 26.3 6.3e-86 287.7 2.7 4.1 4 0 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CRG91076.1 - 5.3e-08 32.4 2.4 0.0073 16.0 0.1 2.9 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Glyco_hydro_cc PF11790.8 CRG91077.1 - 3e-63 213.6 4.8 3.5e-63 213.4 4.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro81C PF17652.1 CRG91078.1 - 3.5e-73 246.8 2.3 5.5e-73 246.2 2.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 CRG91078.1 - 6.8e-35 120.8 5.5 1.5e-34 119.6 5.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain RicinB_lectin_2 PF14200.6 CRG91078.1 - 2.4 8.9 17.9 63 4.4 0.2 4.3 3 1 0 3 3 3 0 Ricin-type beta-trefoil lectin domain-like Myb_DNA-bind_6 PF13921.6 CRG91079.1 - 0.00024 21.3 1.7 0.00049 20.3 1.7 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG91079.1 - 0.047 13.9 1.1 0.1 12.8 1.1 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CRG91079.1 - 0.06 13.5 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 APH PF01636.23 CRG91081.1 - 1.8e-12 47.7 0.1 4e-12 46.6 0.1 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG91081.1 - 7.5e-06 25.7 0.0 1.2e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 CRG91081.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase Pkinase PF00069.25 CRG91081.1 - 0.019 14.4 0.0 0.038 13.3 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain Glyco_hydro_67C PF07477.12 CRG91083.1 - 0.011 15.3 0.2 0.016 14.7 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 C-terminus BCS1_N PF08740.11 CRG91084.1 - 2.1e-33 115.9 0.1 3.6e-33 115.1 0.1 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CRG91084.1 - 1.8e-17 64.0 0.0 4.3e-17 62.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CRG91084.1 - 0.0017 18.1 0.0 0.0029 17.4 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Spec3 PF15795.5 CRG91084.1 - 0.032 14.8 0.1 0.059 13.9 0.1 1.4 1 0 0 1 1 1 0 Ectodermal ciliogenesis protein Toprim_Crpt PF13342.6 CRG91084.1 - 0.12 12.3 0.1 2.6 8.1 0.1 2.4 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase AAA_25 PF13481.6 CRG91084.1 - 0.13 11.9 0.0 0.26 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNase_H PF00075.24 CRG91086.1 - 5.3e-13 49.4 0.0 1.6e-12 47.8 0.0 1.8 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 CRG91086.1 - 0.03 14.1 0.0 0.067 13.0 0.0 1.6 1 0 0 1 1 1 0 Reverse transcriptase-like Ank_2 PF12796.7 CRG91087.1 - 2e-10 41.1 0.0 3.8e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG91087.1 - 8.7e-09 34.9 0.0 0.00031 20.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 CRG91087.1 - 7.6e-08 32.5 0.0 0.0037 17.6 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 CRG91087.1 - 2.4e-07 31.2 0.0 0.003 18.1 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG91087.1 - 7.2e-05 23.0 0.1 0.0073 16.6 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Cas_CXXC_CXXC PF09706.10 CRG91087.1 - 0.17 12.2 0.8 17 5.8 0.1 2.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) HypA PF01155.19 CRG91087.1 - 0.23 11.5 3.7 0.39 10.7 0.6 2.6 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 CRG91087.1 - 0.34 10.9 2.2 0.98 9.4 0.8 2.2 2 0 0 2 2 2 0 zinc-ribbons Cytochrom_c3_2 PF14537.6 CRG91087.1 - 0.84 10.1 3.9 14 6.3 0.3 2.6 2 0 0 2 2 2 0 Cytochrome c3 Lar_restr_allev PF14354.6 CRG91087.1 - 3.9 7.9 6.3 6.6 7.2 0.8 3.1 3 0 0 3 3 3 0 Restriction alleviation protein Lar zf-HIT PF04438.16 CRG91087.1 - 5.2 7.0 8.0 2.9 7.8 1.3 2.8 2 0 0 2 2 2 0 HIT zinc finger BTB PF00651.31 CRG91088.1 - 1.5e-06 28.4 0.0 3.2e-06 27.3 0.0 1.5 2 0 0 2 2 2 1 BTB/POZ domain BTB PF00651.31 CRG91090.1 - 6.2e-18 65.0 0.0 1.6e-17 63.7 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain FAD_binding_8 PF08022.12 CRG91090.1 - 8e-10 38.8 0.0 1.9e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CRG91090.1 - 8.5e-08 32.4 9.5 8.5e-08 32.4 9.5 2.5 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG91090.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Ferric reductase NAD binding domain F-box PF00646.33 CRG91091.1 - 0.0063 16.4 1.1 0.012 15.5 0.1 2.0 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 CRG91091.1 - 0.12 12.3 0.5 0.3 11.0 0.1 1.9 2 0 0 2 2 2 0 F-box APH PF01636.23 CRG91092.1 - 1.7e-19 70.7 0.0 2.5e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 CRG91092.1 - 7.8e-06 25.6 0.0 0.012 15.2 0.0 2.2 2 0 0 2 2 2 2 RIO1 family Choline_kinase PF01633.20 CRG91092.1 - 0.0004 20.0 0.0 0.00064 19.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 CRG91092.1 - 0.0065 15.7 0.1 0.059 12.6 0.0 2.0 2 0 0 2 2 2 1 Fructosamine kinase RNA_polI_A14 PF08203.11 CRG91092.1 - 0.012 16.3 0.1 0.024 15.4 0.1 1.4 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 Myb_DNA-bind_2 PF08914.11 CRG91092.1 - 0.033 14.3 0.0 0.1 12.8 0.0 1.8 2 0 0 2 2 2 0 Rap1 Myb domain Pkinase PF00069.25 CRG91092.1 - 0.054 12.8 0.0 1.4 8.2 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain muHD PF10291.9 CRG91093.1 - 0.038 13.4 0.0 0.084 12.3 0.0 1.6 1 1 0 1 1 1 0 Muniscin C-terminal mu homology domain HEAT PF02985.22 CRG91093.1 - 0.062 13.6 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 HEAT repeat DUF1487 PF07368.11 CRG91094.1 - 0.23 10.9 0.0 0.34 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) DUF3723 PF12520.8 CRG91095.1 - 1.5e-190 634.2 0.0 1.5e-190 634.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3723) Pkinase PF00069.25 CRG91096.1 - 7.4e-10 38.6 0.0 1e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91096.1 - 1.1e-05 24.9 0.1 1.5e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RdRP PF05183.12 CRG91097.1 - 1.6e-179 598.3 0.0 2.1e-179 598.0 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Methyltransf_23 PF13489.6 CRG91098.1 - 2e-10 40.7 0.0 6.7e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG91098.1 - 3e-05 24.7 1.0 0.00099 19.8 0.0 3.6 4 1 0 4 4 4 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG91098.1 - 0.0024 18.6 1.7 0.018 15.7 0.2 3.3 3 1 0 3 3 3 1 Methyltransferase domain Med9 PF07544.13 CRG91098.1 - 0.0036 17.4 3.1 0.0088 16.1 3.1 1.6 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Methyltransf_11 PF08241.12 CRG91098.1 - 0.11 13.1 0.5 1.6 9.4 0.1 3.2 3 1 0 3 3 3 0 Methyltransferase domain Tagatose_6_P_K PF08013.11 CRG91098.1 - 0.19 10.4 0.2 0.28 9.8 0.2 1.2 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase Methyltransf_31 PF13847.6 CRG91098.1 - 0.26 11.1 0.9 8 6.2 0.5 3.0 3 0 0 3 3 3 0 Methyltransferase domain zf-C2H2 PF00096.26 CRG91098.1 - 0.28 11.7 0.1 0.28 11.7 0.1 2.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF3435 PF11917.8 CRG91099.1 - 2.1e-151 504.6 0.7 2.7e-151 504.2 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Phage_integrase PF00589.22 CRG91099.1 - 0.0056 16.5 1.8 0.036 13.9 0.0 2.7 3 0 0 3 3 3 1 Phage integrase family Pinin_SDK_memA PF04696.13 CRG91099.1 - 0.03 14.4 9.5 0.078 13.0 9.5 1.7 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region zf-met PF12874.7 CRG91099.1 - 0.17 12.3 0.6 0.46 10.9 0.6 1.8 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DUF4407 PF14362.6 CRG91099.1 - 0.43 9.9 2.8 0.61 9.4 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C2H2 PF00096.26 CRG91099.1 - 0.84 10.2 4.9 10 6.8 0.5 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG91099.1 - 2.1 9.4 3.8 6.7 7.8 0.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Ribosomal_L27A PF00828.19 CRG91100.1 - 3.5e-23 82.7 0.0 5.1e-23 82.2 0.0 1.2 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Chitin_synth_1 PF01644.17 CRG91101.1 - 7.3e-75 250.4 0.0 1.2e-74 249.8 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CRG91101.1 - 4.6e-30 103.4 0.0 1e-29 102.3 0.0 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CRG91101.1 - 6.6e-23 81.1 3.7 2.7e-18 65.9 0.0 2.3 2 0 0 2 2 2 2 Chitin synthase TMEM234 PF10639.9 CRG91102.1 - 8.9e-37 125.7 2.0 1.6e-36 124.9 2.0 1.4 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 CRG91102.1 - 0.0012 19.1 6.1 0.32 11.1 4.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF846 PF05832.12 CRG91102.1 - 0.0074 16.3 1.0 0.012 15.7 0.7 1.5 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Glyco_hydro_43 PF04616.14 CRG91103.1 - 5e-66 223.0 1.4 6.4e-66 222.6 1.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 GH43_C2 PF17851.1 CRG91103.1 - 3.2e-33 115.2 0.0 4.6e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Beta xylosidase C-terminal Concanavalin A-like domain DUF5005 PF16396.5 CRG91103.1 - 0.0031 16.2 0.1 0.011 14.5 0.1 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF5005) Sugar_tr PF00083.24 CRG91104.1 - 5.2e-97 325.5 24.5 6.1e-97 325.3 24.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91104.1 - 2.3e-34 118.9 51.0 7.6e-29 100.7 23.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG91104.1 - 0.15 10.6 22.3 0.039 12.5 6.3 3.1 2 1 0 2 2 2 0 MFS/sugar transport protein Peptidase_A4 PF01828.17 CRG91105.1 - 4.3e-67 225.6 16.9 5.6e-67 225.3 16.9 1.1 1 0 0 1 1 1 1 Peptidase A4 family DUF2235 PF09994.9 CRG91106.1 - 5.8e-28 98.1 1.5 4.3e-27 95.2 0.3 2.1 2 0 0 2 2 2 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SnoaL_2 PF12680.7 CRG91106.1 - 0.0051 17.4 0.0 0.011 16.4 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like domain RE_NgoFVII PF09565.10 CRG91106.1 - 0.086 12.1 0.2 0.14 11.5 0.2 1.2 1 0 0 1 1 1 0 NgoFVII restriction endonuclease Atrophin-1 PF03154.15 CRG91106.1 - 0.34 9.1 8.9 0.48 8.6 8.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family ADH_N PF08240.12 CRG91107.1 - 2.4e-24 85.3 5.1 4.1e-24 84.6 5.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG91107.1 - 1.8e-20 73.2 0.0 3e-20 72.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF3425 PF11905.8 CRG91107.1 - 4.9e-17 62.1 0.5 8.8e-17 61.2 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) ADH_zinc_N_2 PF13602.6 CRG91107.1 - 1.4e-07 32.7 0.0 2.7e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 CRG91107.1 - 0.0051 16.1 0.1 0.011 15.0 0.0 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain GFO_IDH_MocA PF01408.22 CRG91107.1 - 0.061 14.2 0.6 4.6 8.1 0.4 3.0 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Acetyltransf_7 PF13508.7 CRG91108.1 - 1.9e-06 28.2 0.0 5e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG91108.1 - 0.00021 21.2 0.0 0.00042 20.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG91108.1 - 0.0046 17.2 0.0 0.0093 16.2 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family AA_permease_2 PF13520.6 CRG91109.1 - 4.9e-54 183.8 48.1 6.5e-54 183.4 48.1 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG91109.1 - 3.2e-34 118.4 34.8 3.2e-34 118.4 34.8 1.9 2 0 0 2 2 2 1 Amino acid permease DUF2263 PF10021.9 CRG91110.1 - 3.5e-23 82.6 0.1 1.4e-22 80.6 0.1 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) Macro PF01661.21 CRG91110.1 - 0.06 13.4 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Macro domain TniB PF05621.11 CRG91110.1 - 0.14 11.6 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein RibD_C PF01872.17 CRG91111.1 - 8.6e-29 100.8 0.0 2.5e-14 53.6 0.0 2.1 1 1 0 2 2 2 2 RibD C-terminal domain MRC1 PF09444.10 CRG91112.1 - 4.8e-40 137.4 21.5 4.8e-40 137.4 21.5 8.5 6 2 3 9 9 9 1 MRC1-like domain HTH_39 PF14090.6 CRG91112.1 - 0.075 12.8 0.2 0.19 11.5 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Plus-3 PF03126.18 CRG91113.1 - 9.2e-32 109.8 0.0 7.8e-31 106.8 0.0 2.2 2 0 0 2 2 2 1 Plus-3 domain COQ7 PF03232.13 CRG91114.1 - 1.7e-67 226.5 0.7 2.3e-67 226.1 0.7 1.2 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 CRG91114.1 - 5.6e-05 23.6 0.2 0.00015 22.2 0.0 1.7 1 1 1 2 2 2 1 Rubrerythrin FAD_binding_4 PF01565.23 CRG91115.1 - 8.5e-27 93.6 2.3 1.2e-26 93.1 2.3 1.2 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG91115.1 - 4.4e-14 52.3 0.0 1.2e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Berberine and berberine like LigD_N PF13298.6 CRG91116.1 - 2.8e-37 127.2 0.1 5.3e-37 126.3 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase Ligase (LigD) ABC_tran PF00005.27 CRG91117.1 - 1.5e-48 164.8 0.1 1.4e-29 103.4 0.0 2.9 3 0 0 3 3 2 2 ABC transporter ABC_membrane PF00664.23 CRG91117.1 - 1.5e-45 156.0 25.6 4e-28 98.8 14.1 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG91117.1 - 6.2e-10 38.9 0.4 0.069 12.6 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 CRG91117.1 - 5.9e-07 30.2 0.1 4.5e-05 24.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 CRG91117.1 - 4.6e-05 23.7 0.5 0.35 11.1 0.0 3.6 3 1 0 3 3 2 2 AAA domain AAA_29 PF13555.6 CRG91117.1 - 0.0001 22.0 0.4 0.064 13.0 0.2 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 CRG91117.1 - 0.00027 21.4 0.4 0.98 9.8 0.1 3.1 3 0 0 3 3 2 2 AAA ATPase domain T2SSE PF00437.20 CRG91117.1 - 0.0003 19.9 0.1 0.12 11.4 0.0 2.8 2 1 1 3 3 3 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 CRG91117.1 - 0.00084 19.4 0.1 0.11 12.6 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 CRG91117.1 - 0.0011 18.9 0.0 1.5 8.7 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase DUF87 PF01935.17 CRG91117.1 - 0.0014 18.8 1.1 0.61 10.1 0.0 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_21 PF13304.6 CRG91117.1 - 0.0079 16.0 0.8 13 5.5 0.0 3.5 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system IstB_IS21 PF01695.17 CRG91117.1 - 0.011 15.4 0.0 1.2 8.8 0.0 3.2 4 0 0 4 4 3 0 IstB-like ATP binding protein AAA_10 PF12846.7 CRG91117.1 - 0.019 13.9 0.1 0.86 8.5 0.0 2.3 2 0 0 2 2 2 0 AAA-like domain DUF2075 PF09848.9 CRG91117.1 - 0.054 12.7 0.2 0.61 9.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 CRG91117.1 - 0.077 13.1 1.2 27 4.8 0.0 3.0 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain NB-ARC PF00931.22 CRG91117.1 - 0.079 12.1 0.1 21 4.2 0.0 3.1 3 0 0 3 3 3 0 NB-ARC domain MeaB PF03308.16 CRG91117.1 - 0.11 11.5 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 CRG91117.1 - 0.12 12.1 0.2 5.3 6.6 0.2 2.3 2 0 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 CRG91117.1 - 0.5 9.2 2.3 1.1 8.1 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.19 CRG91117.1 - 2.1 7.9 4.8 6.3 6.3 0.8 3.3 4 0 0 4 4 4 0 CobW/HypB/UreG, nucleotide-binding domain Acetyltransf_1 PF00583.25 CRG91118.1 - 2.9e-09 37.2 0.0 7.4e-09 35.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG91118.1 - 4e-09 36.5 0.0 6.2e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG91118.1 - 3.4e-07 30.6 0.0 5.2e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG91118.1 - 1.5e-06 28.1 0.0 3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 CRG91118.1 - 1.5e-05 25.7 0.0 1.9e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG91118.1 - 0.00035 20.6 0.0 0.00062 19.9 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_8 PF13523.6 CRG91118.1 - 0.0053 16.4 0.0 0.0079 15.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 CRG91118.1 - 0.096 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Raffinose_syn PF05691.12 CRG91119.1 - 4.2e-46 157.1 4.1 1.5e-40 138.8 0.2 2.6 2 1 1 3 3 3 2 Raffinose synthase or seed imbibition protein Sip1 RRN9 PF10680.9 CRG91121.1 - 1.7e-05 25.0 3.2 0.00014 22.1 3.2 2.7 1 1 0 1 1 1 1 RNA polymerase I specific transcription initiation factor zf-C2H2 PF00096.26 CRG91121.1 - 0.00083 19.7 18.1 0.28 11.7 0.5 4.4 4 1 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG91121.1 - 0.027 15.3 9.7 2.6 9.1 0.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 CRG91121.1 - 0.24 11.6 0.2 23 5.1 0.0 2.7 2 1 0 3 3 3 0 Aberrant zinc-finger Pescadillo_N PF06732.11 CRG91122.1 - 1.4e-123 411.8 0.1 1.4e-123 411.8 0.1 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 CRG91122.1 - 0.00052 20.4 0.0 0.0029 18.0 0.0 2.3 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 CRG91122.1 - 0.14 12.4 0.0 0.42 10.9 0.0 1.8 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain BRCT PF00533.26 CRG91122.1 - 0.17 12.3 0.0 6.5 7.2 0.0 3.2 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain DUF2457 PF10446.9 CRG91122.1 - 0.45 9.6 34.4 0.8 8.8 34.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PIG-U PF06728.13 CRG91123.1 - 2.3e-123 412.1 29.2 2.6e-123 411.9 29.2 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Acetyltransf_1 PF00583.25 CRG91124.1 - 4.6e-14 52.7 0.0 6.9e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG91124.1 - 2.9e-08 34.0 0.1 4.7e-08 33.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 CRG91124.1 - 4.6e-07 29.8 0.0 8.4e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG91124.1 - 4.2e-05 23.4 0.0 8.7e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CRG91124.1 - 0.0041 17.2 0.0 0.0076 16.4 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 CRG91124.1 - 0.02 15.6 0.0 0.035 14.8 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 CRG91125.1 - 1.1e-48 163.8 6.0 5.3e-16 59.0 0.0 8.4 5 4 4 9 9 9 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG91125.1 - 3.4e-38 129.5 5.8 1.5e-10 41.4 0.0 9.3 8 2 2 10 10 10 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG91125.1 - 8.7e-30 101.8 12.0 0.00015 22.0 0.0 10.9 10 1 1 11 11 11 6 Ankyrin repeat Ank_3 PF13606.6 CRG91125.1 - 8.8e-29 96.4 8.6 0.0098 16.3 0.0 10.9 10 0 0 10 10 10 7 Ankyrin repeat Ank_5 PF13857.6 CRG91125.1 - 2.8e-21 75.3 12.4 0.0003 21.0 0.0 9.0 7 2 3 10 10 10 6 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 CRG91125.1 - 2.2e-09 36.9 0.0 5.9e-09 35.5 0.0 1.7 1 1 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG91125.1 - 3.3e-08 33.6 0.0 7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 CRG91125.1 - 0.012 15.8 0.0 0.031 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CRG91125.1 - 0.083 12.9 0.0 1.6 8.8 0.0 2.5 1 1 0 1 1 1 0 AAA domain Aldedh PF00171.22 CRG91126.1 - 7.2e-169 562.2 1.0 8.1e-169 562.0 1.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1929 PF09118.11 CRG91127.1 - 1.7e-22 79.5 0.1 4.2e-22 78.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 CRG91127.1 - 4e-13 49.1 7.5 4.7e-08 33.0 0.0 5.3 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.25 CRG91127.1 - 3e-12 45.9 0.2 9.9e-05 21.9 0.2 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 CRG91127.1 - 9e-09 35.0 4.4 0.0007 19.5 0.2 4.5 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 CRG91127.1 - 3.1e-08 33.5 9.5 0.0078 16.2 0.2 5.1 4 1 0 4 4 4 2 Galactose oxidase, central domain Glyoxal_oxid_N PF07250.11 CRG91127.1 - 3.7e-08 32.9 0.1 0.0084 15.3 0.1 2.7 2 1 1 3 3 3 2 Glyoxal oxidase N-terminus Kelch_3 PF13415.6 CRG91127.1 - 0.0037 17.5 0.0 1.5 9.2 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain FAD_binding_4 PF01565.23 CRG91127.1 - 0.13 12.0 0.5 0.7 9.6 0.1 2.4 2 1 2 4 4 4 0 FAD binding domain DUF5122 PF17164.4 CRG91127.1 - 1.9 8.9 8.5 6.6 7.1 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller Ank_2 PF12796.7 CRG91128.1 - 3.6e-51 171.7 12.6 1.2e-12 48.3 0.1 6.1 3 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG91128.1 - 1.5e-40 137.1 1.3 9e-09 35.7 0.1 7.3 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG91128.1 - 3.1e-28 97.5 3.1 6.1e-06 26.4 0.1 7.4 2 2 6 8 8 8 8 Ankyrin repeats (many copies) Pro-kuma_activ PF09286.11 CRG91128.1 - 1e-27 97.2 0.1 1.2e-23 84.0 0.0 3.3 3 0 0 3 3 3 2 Pro-kumamolisin, activation domain Ank PF00023.30 CRG91128.1 - 8.3e-26 89.3 7.5 0.0085 16.5 0.0 9.0 9 0 0 9 9 8 7 Ankyrin repeat Ank_3 PF13606.6 CRG91128.1 - 1.9e-25 86.1 1.2 0.011 16.2 0.0 9.4 10 0 0 10 10 9 7 Ankyrin repeat Peptidase_S8 PF00082.22 CRG91128.1 - 1e-06 28.3 0.4 1.8e-06 27.4 0.4 1.3 1 0 0 1 1 1 1 Subtilase family NACHT PF05729.12 CRG91128.1 - 1.5e-06 28.2 0.0 3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 CRG91128.1 - 3.7e-05 23.1 0.0 0.00014 21.2 0.0 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG91128.1 - 0.00021 21.7 0.0 0.057 13.8 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 CRG91128.1 - 0.024 15.0 0.0 0.46 10.9 0.0 2.9 3 0 0 3 3 2 0 RNA helicase MFS_1 PF07690.16 CRG91129.1 - 5.9e-18 64.9 25.0 5.9e-18 64.9 25.0 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91129.1 - 0.00012 21.1 20.5 0.0005 19.1 20.5 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter R3H PF01424.22 CRG91130.1 - 3.7e-12 46.0 0.3 8.5e-12 44.9 0.0 1.7 2 0 0 2 2 2 1 R3H domain Glyco_hydro_92 PF07971.12 CRG91131.1 - 7e-153 509.9 1.9 8.4e-153 509.6 1.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CRG91131.1 - 1e-57 195.8 1.0 1.8e-57 195.0 1.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain MFS_1 PF07690.16 CRG91132.1 - 1.5e-41 142.5 47.0 2.1e-41 142.0 46.3 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily TMC PF07810.13 CRG91132.1 - 0.12 12.9 3.4 0.44 11.2 0.6 2.6 2 0 0 2 2 2 0 TMC domain Evr1_Alr PF04777.13 CRG91133.1 - 4.9e-26 91.1 0.1 7.8e-26 90.5 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family APOBEC4 PF18775.1 CRG91133.1 - 0.038 14.1 0.2 0.071 13.3 0.2 1.4 1 0 0 1 1 1 0 APOBEC4 RTA1 PF04479.13 CRG91135.1 - 1.1e-44 152.5 10.0 1.1e-44 152.5 10.0 1.5 2 0 0 2 2 2 1 RTA1 like protein DUF3439 PF11921.8 CRG91135.1 - 0.02 14.9 5.8 0.02 14.9 5.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF805 PF05656.14 CRG91135.1 - 3.7 8.0 10.5 2.7 8.5 1.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Aminotran_4 PF01063.19 CRG91136.1 - 2.3e-28 99.6 0.0 3e-28 99.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Aldo_ket_red PF00248.21 CRG91137.1 - 3.6e-66 223.4 0.0 4.4e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Glyco_hydro_61 PF03443.14 CRG91138.1 - 0.00064 19.7 0.0 0.0024 17.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 CRG91138.1 - 0.00074 20.2 0.1 0.0017 19.1 0.1 1.5 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading PPC PF04151.15 CRG91138.1 - 0.098 13.8 0.0 0.3 12.2 0.0 1.8 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain NfI_DNAbd_pre-N PF10524.9 CRG91138.1 - 0.13 12.1 0.2 0.22 11.4 0.2 1.3 1 0 0 1 1 1 0 Nuclear factor I protein pre-N-terminus PA14 PF07691.12 CRG91138.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 PA14 domain Mannosidase_ig PF17786.1 CRG91139.1 - 6.7e-16 58.7 0.6 1.8e-15 57.3 0.1 2.1 2 0 0 2 2 2 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CRG91139.1 - 2.6e-13 50.6 1.8 3.4e-13 50.2 0.6 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Methyltransf_2 PF00891.18 CRG91140.1 - 1.2e-22 80.3 0.0 1.6e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CRG91140.1 - 0.0023 18.6 0.0 0.0067 17.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ATP11 PF06644.11 CRG91141.1 - 1.2e-102 343.3 0.0 1.4e-102 343.1 0.0 1.0 1 0 0 1 1 1 1 ATP11 protein MAP65_ASE1 PF03999.12 CRG91141.1 - 0.0029 16.4 1.5 0.0035 16.1 1.5 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) CCDC24 PF15669.5 CRG91141.1 - 0.0094 15.8 2.8 0.0094 15.8 2.8 1.6 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 24 family FAM60A PF15396.6 CRG91141.1 - 0.013 15.6 0.2 0.017 15.2 0.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A MAGE_N PF12440.8 CRG91141.1 - 0.33 11.7 22.3 1.4 9.6 15.0 2.9 3 0 0 3 3 3 0 Melanoma associated antigen family N terminal MID_MedPIWI PF18296.1 CRG91141.1 - 2.4 7.9 8.1 3.3 7.4 8.1 1.3 1 1 0 1 1 1 0 MID domain of medPIWI Hydrolase_4 PF12146.8 CRG91142.1 - 1.3e-15 57.3 0.0 1.9e-10 40.4 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG91142.1 - 2.3e-13 50.4 0.0 1.5e-09 37.9 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 CRG91142.1 - 2.5e-06 26.4 0.1 0.033 12.9 0.1 2.7 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 CRG91142.1 - 4.8e-06 27.3 0.0 1.5e-05 25.7 0.0 1.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family FSH1 PF03959.13 CRG91142.1 - 6e-05 22.8 0.0 0.00025 20.8 0.0 2.0 2 1 0 2 2 2 1 Serine hydrolase (FSH1) LIDHydrolase PF10230.9 CRG91142.1 - 0.00046 19.8 0.0 0.0025 17.4 0.0 1.9 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase DUF818 PF05677.12 CRG91142.1 - 0.00047 19.2 0.0 0.00066 18.7 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_3 PF07859.13 CRG91142.1 - 0.0021 18.0 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CRG91142.1 - 0.0024 17.7 0.1 0.38 10.5 0.0 2.5 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CRG91142.1 - 0.0038 16.7 0.0 0.059 12.8 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family PGAP1 PF07819.13 CRG91142.1 - 0.007 16.1 0.1 0.063 13.0 0.1 2.3 1 1 0 1 1 1 1 PGAP1-like protein DLH PF01738.18 CRG91142.1 - 0.0072 15.9 0.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Lipase_3 PF01764.25 CRG91142.1 - 0.052 13.4 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) BAAT_C PF08840.11 CRG91142.1 - 0.057 13.3 0.0 0.35 10.8 0.0 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Esterase PF00756.20 CRG91142.1 - 0.061 13.0 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Proteasome PF00227.26 CRG91143.1 - 8.1e-47 159.2 0.4 1e-46 158.9 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Cyclin PF08613.11 CRG91144.1 - 1.8e-36 126.0 0.8 6.6e-24 85.1 0.1 3.5 3 2 0 3 3 3 2 Cyclin TFIIA PF03153.13 CRG91145.1 - 0.54 10.2 12.3 0.61 10.0 12.3 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PrpF PF04303.13 CRG91147.1 - 2.8e-111 372.1 0.1 3.3e-111 371.9 0.1 1.0 1 0 0 1 1 1 1 PrpF protein DAP_epimerase PF01678.19 CRG91147.1 - 0.12 12.6 0.1 0.74 10.0 0.0 2.3 2 0 0 2 2 2 0 Diaminopimelate epimerase Peptidase_C48 PF02902.19 CRG91149.1 - 4.7e-16 59.3 0.1 1.1e-15 58.1 0.1 1.6 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF4951 PF16309.5 CRG91149.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) RhoGEF PF00621.20 CRG91150.1 - 3.5e-37 128.4 0.1 7.5e-37 127.3 0.1 1.6 1 0 0 1 1 1 1 RhoGEF domain BAR PF03114.18 CRG91150.1 - 1.3e-11 44.7 2.3 3.1e-11 43.4 2.3 1.7 1 0 0 1 1 1 1 BAR domain Telomerase_RBD PF12009.8 CRG91151.1 - 1.5e-47 161.0 0.2 3e-47 160.1 0.2 1.5 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 CRG91151.1 - 2e-14 53.6 0.0 1.5e-09 37.7 0.0 2.6 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) CAMSAP_CH PF11971.8 CRG91151.1 - 0.0096 15.7 0.0 27 4.7 0.0 3.8 3 0 0 3 3 3 2 CAMSAP CH domain MFS_1 PF07690.16 CRG91152.1 - 3.8e-34 118.2 29.6 3.8e-34 118.2 29.6 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 CRG91152.1 - 6e-17 61.9 0.0 2e-15 56.9 0.0 2.6 2 1 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 CRG91152.1 - 6.3e-09 35.4 0.3 1.5e-06 27.6 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 CRG91152.1 - 1.3e-07 31.2 0.8 0.00022 20.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG91152.1 - 1.1e-06 28.6 0.3 0.0037 16.9 0.1 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91152.1 - 1.3e-05 25.3 0.1 3.6e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 CRG91152.1 - 0.00021 21.8 0.4 0.0045 17.5 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG91152.1 - 0.00029 20.3 0.4 0.0009 18.7 0.4 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG91152.1 - 0.00037 19.3 0.2 0.00072 18.4 0.1 1.5 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CRG91152.1 - 0.0086 15.2 0.0 0.013 14.6 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 CRG91152.1 - 0.0096 15.2 0.0 0.022 14.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CRG91152.1 - 0.017 14.4 0.3 0.041 13.1 0.3 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 CRG91152.1 - 0.12 11.7 0.0 0.34 10.2 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 CRG91152.1 - 0.18 11.1 0.1 0.32 10.2 0.1 1.3 1 0 0 1 1 1 0 Thi4 family p450 PF00067.22 CRG91153.1 - 1.8e-75 254.5 0.0 2.4e-75 254.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG91153.1 - 3.3e-46 157.9 37.0 3.3e-46 157.9 37.0 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91153.1 - 4.3e-14 52.2 5.5 4.3e-14 52.2 5.5 2.0 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 CRG91153.1 - 1.8e-07 30.8 6.8 5.1e-07 29.3 6.8 1.7 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB UL42 PF17638.2 CRG91153.1 - 0.09 12.8 0.2 0.32 11.0 0.2 1.9 1 0 0 1 1 1 0 HCMV UL42 Glyco_hydro_31 PF01055.26 CRG91154.1 - 4.2e-112 375.6 1.0 6.1e-112 375.0 1.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 CRG91154.1 - 0.00055 20.2 2.0 0.0024 18.2 0.2 3.0 2 1 0 2 2 2 1 Galactose mutarotase-like DUF4968 PF16338.5 CRG91154.1 - 0.0034 17.7 0.0 0.0057 16.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) adh_short PF00106.25 CRG91155.1 - 4.1e-35 121.0 1.5 9.2e-35 119.9 1.5 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91155.1 - 1.2e-21 77.4 0.6 1.8e-21 76.8 0.6 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91155.1 - 6.6e-10 39.2 0.3 9.4e-10 38.7 0.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG91155.1 - 8.8e-06 25.4 0.1 1.1e-05 25.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 CRG91155.1 - 3.4e-05 23.5 0.6 4.8e-05 23.0 0.6 1.3 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CRG91155.1 - 0.00011 21.8 0.0 0.00012 21.7 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG91155.1 - 0.011 15.6 0.4 0.018 14.9 0.4 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Ribosomal_L2 PF00181.23 CRG91155.1 - 0.054 13.5 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain Sugar_tr PF00083.24 CRG91156.1 - 7.7e-75 252.5 22.2 8.9e-75 252.3 22.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91156.1 - 1.6e-18 66.8 15.1 1.6e-18 66.8 15.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Fzo_mitofusin PF04799.13 CRG91156.1 - 0.38 10.3 1.2 0.56 9.7 0.0 1.9 2 0 0 2 2 2 0 fzo-like conserved region DUF21 PF01595.20 CRG91156.1 - 6.7 6.4 8.1 5.8 6.6 5.6 2.1 1 1 0 1 1 1 0 Cyclin M transmembrane N-terminal domain DUF2070 PF09843.9 CRG91156.1 - 8.7 4.5 12.4 17 3.5 12.4 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) AAA_12 PF13087.6 CRG91157.1 - 1.5e-14 54.1 0.0 3e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CRG91157.1 - 1.6e-14 54.4 4.7 1.4e-13 51.2 0.3 3.0 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CRG91157.1 - 2e-07 30.9 0.0 0.00059 19.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 CRG91157.1 - 0.00018 21.8 0.3 0.0025 18.2 0.3 2.5 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 CRG91157.1 - 0.0092 15.3 0.0 0.02 14.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 CRG91157.1 - 0.0096 15.5 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 CRG91157.1 - 0.017 14.5 0.0 0.053 13.0 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Zn-ribbon_8 PF09723.10 CRG91157.1 - 0.38 10.9 3.5 3.2 8.0 1.4 2.7 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 CRG91157.1 - 0.82 9.7 4.0 13 5.9 2.0 2.5 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 CRG91157.1 - 0.88 9.4 3.4 11 5.9 0.7 2.8 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 CRG91157.1 - 3.1 7.4 4.8 0.82 9.2 0.6 2.3 2 0 0 2 2 2 0 zinc-ribbon domain ThiF PF00899.21 CRG91158.1 - 2.5e-58 197.3 0.0 4e-58 196.7 0.0 1.3 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 CRG91158.1 - 2.9e-10 40.6 0.0 7.3e-10 39.3 0.0 1.7 2 0 0 2 2 2 1 Rhodanese-like domain CCDC144C PF14915.6 CRG91158.1 - 0.017 14.2 0.8 0.017 14.2 0.8 1.4 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region ApbA PF02558.16 CRG91158.1 - 0.16 11.6 0.0 0.3 10.7 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 CRG91159.1 - 2.1e-25 89.8 0.0 3.6e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain p450 PF00067.22 CRG91159.1 - 1.4e-17 63.7 0.3 2.1e-16 59.8 0.1 2.3 2 1 0 2 2 2 1 Cytochrome P450 DAO PF01266.24 CRG91159.1 - 8e-06 25.7 0.8 0.0071 16.0 0.6 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91159.1 - 0.0019 18.4 0.2 0.0054 16.9 0.2 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CRG91159.1 - 0.014 14.7 1.4 0.12 11.5 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG91159.1 - 0.024 13.7 1.2 3.3 6.7 0.2 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 CRG91159.1 - 0.1 11.4 0.3 2.3 7.0 0.2 2.4 2 0 0 2 2 2 0 Tryptophan halogenase SieB PF14163.6 CRG91159.1 - 0.13 11.7 0.0 3.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Super-infection exclusion protein B Pyr_redox_2 PF07992.14 CRG91159.1 - 0.16 11.2 3.6 0.6 9.3 0.5 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG91159.1 - 0.22 10.6 0.5 0.64 9.0 0.5 1.7 1 1 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 CRG91161.1 - 1.6e-53 182.2 0.0 2.1e-53 181.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG91161.1 - 1.5e-09 37.9 0.8 1.4e-05 24.9 0.3 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG91161.1 - 4.9e-07 29.3 0.0 0.00018 20.9 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG91161.1 - 4.2e-06 26.9 0.1 9.5e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG91161.1 - 1.4e-05 24.5 0.0 3.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 CRG91161.1 - 1.5e-05 24.1 0.0 0.0087 15.0 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 CRG91161.1 - 6.7e-05 23.4 0.1 0.00038 20.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91161.1 - 7.5e-05 21.6 0.1 0.00086 18.1 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 CRG91161.1 - 9.2e-05 21.6 0.2 0.0086 15.2 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG91161.1 - 0.00023 20.5 0.1 0.00055 19.3 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG91161.1 - 0.00035 19.8 0.1 0.00058 19.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CRG91161.1 - 0.0011 18.4 0.0 0.0025 17.3 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase ApbA PF02558.16 CRG91161.1 - 0.0021 17.7 0.1 0.0037 16.9 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.23 CRG91161.1 - 0.0055 16.7 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TrkA_N PF02254.18 CRG91161.1 - 0.01 16.1 0.0 0.022 15.0 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 CRG91161.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 CRG91161.1 - 0.017 14.7 0.1 0.033 13.7 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain K_oxygenase PF13434.6 CRG91161.1 - 0.021 14.0 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) F420_oxidored PF03807.17 CRG91161.1 - 0.062 13.9 0.0 0.18 12.4 0.0 1.9 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_9 PF13454.6 CRG91161.1 - 0.072 13.1 0.2 0.99 9.4 0.1 2.6 3 0 0 3 3 3 0 FAD-NAD(P)-binding Sacchrp_dh_NADP PF03435.18 CRG91161.1 - 0.11 12.8 0.1 5 7.4 0.1 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain XdhC_C PF13478.6 CRG91161.1 - 0.12 12.8 0.0 0.33 11.5 0.0 1.8 2 0 0 2 2 2 0 XdhC Rossmann domain Glyco_hydro_65m PF03632.15 CRG91163.1 - 3.6e-36 124.9 0.6 1.8e-31 109.4 0.1 2.4 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 CRG91163.1 - 5.2e-27 95.0 0.0 8.6e-27 94.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain F5_F8_type_C PF00754.25 CRG91163.1 - 5.2e-08 33.1 2.1 8e-08 32.5 0.1 2.4 2 0 0 2 2 2 1 F5/8 type C domain Glyco_hydro_65C PF03633.15 CRG91163.1 - 0.002 18.0 0.0 0.0064 16.4 0.0 1.9 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, C-terminal domain p450 PF00067.22 CRG91164.1 - 7.2e-38 130.5 0.0 3.9e-29 101.7 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 FSH1 PF03959.13 CRG91165.1 - 4.2e-18 65.8 0.0 6.3e-18 65.2 0.0 1.6 1 1 0 1 1 1 1 Serine hydrolase (FSH1) KR PF08659.10 CRG91166.1 - 8.1e-63 211.6 0.0 1.6e-62 210.6 0.0 1.6 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 CRG91166.1 - 1.1e-62 211.9 0.0 2.1e-62 211.0 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG91166.1 - 2.1e-56 191.4 0.0 3.1e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG91166.1 - 3.5e-42 145.0 0.0 3e-41 142.0 0.0 2.3 1 1 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG91166.1 - 4.3e-37 126.7 0.1 1.3e-36 125.2 0.1 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG91166.1 - 2.3e-17 63.6 0.0 6.1e-17 62.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CRG91166.1 - 1.2e-15 57.6 0.0 3.6e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 CRG91166.1 - 4.4e-15 56.1 0.2 2.3e-10 40.9 0.0 3.4 3 0 0 3 3 3 2 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 CRG91166.1 - 8.7e-14 51.7 0.0 2.1e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CRG91166.1 - 1.7e-13 50.5 0.0 1e-12 47.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N_2 PF13602.6 CRG91166.1 - 2.5e-12 48.0 0.0 1.2e-11 45.8 0.0 2.2 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 CRG91166.1 - 2.9e-09 37.5 0.0 1.7e-08 35.1 0.0 2.5 2 1 0 2 2 1 1 Methyltransferase domain ADH_N PF08240.12 CRG91166.1 - 6.7e-08 32.4 0.3 2.1e-07 30.8 0.3 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Methyltransf_31 PF13847.6 CRG91166.1 - 8.2e-08 32.2 0.0 2.2e-07 30.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG91166.1 - 1.6e-07 31.9 0.0 5.3e-07 30.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 CRG91166.1 - 8.5e-07 28.8 0.0 2e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Ubie_methyltran PF01209.18 CRG91166.1 - 2.1e-06 27.3 0.0 5e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PP-binding PF00550.25 CRG91166.1 - 1.1e-05 25.6 0.0 3.1e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CRG91166.1 - 3.1e-05 23.5 0.1 6.2e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_16 PF10294.9 CRG91166.1 - 0.084 12.6 0.0 0.38 10.5 0.0 2.0 1 1 0 1 1 1 0 Lysine methyltransferase Polysacc_synt_2 PF02719.15 CRG91166.1 - 0.15 11.2 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DPBB_1 PF03330.18 CRG91167.1 - 2.2e-05 24.6 0.1 5e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Lytic transglycolase NmrA PF05368.13 CRG91168.1 - 7e-19 68.3 0.0 9.9e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG91168.1 - 4.6e-14 52.7 0.0 8.1e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CRG91168.1 - 4.9e-05 23.3 0.0 0.0021 18.0 0.0 2.3 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CRG91168.1 - 0.011 15.3 0.0 0.027 13.9 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Prophage_tail PF06605.11 CRG91168.1 - 0.017 14.4 0.5 0.046 12.9 0.0 2.0 3 0 0 3 3 3 0 Prophage endopeptidase tail Polysacc_synt_2 PF02719.15 CRG91168.1 - 0.076 12.1 0.0 0.2 10.8 0.0 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 CRG91168.1 - 0.11 11.6 0.1 2.8 7.0 0.0 2.3 2 0 0 2 2 2 0 Male sterility protein Pyr_redox_2 PF07992.14 CRG91169.1 - 4.5e-19 68.8 0.1 7.6e-18 64.8 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG91169.1 - 1.2e-05 24.8 0.0 0.033 13.4 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91169.1 - 0.0023 16.7 0.0 0.079 11.7 0.0 2.4 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_9 PF13454.6 CRG91169.1 - 0.0033 17.4 1.0 2.4 8.2 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 CRG91169.1 - 0.013 14.7 0.1 0.62 9.1 0.0 2.6 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 CRG91169.1 - 0.034 13.4 0.1 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 CRG91169.1 - 0.068 12.2 0.2 0.36 9.8 0.1 1.9 1 1 0 2 2 2 0 Lycopene cyclase protein PdaC PF13739.6 CRG91169.1 - 0.082 13.9 0.0 0.19 12.7 0.0 1.6 1 0 0 1 1 1 0 Deacetylase PdaC NAD_binding_8 PF13450.6 CRG91169.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain adh_short PF00106.25 CRG91170.1 - 4.4e-31 107.9 0.1 6.2e-31 107.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91170.1 - 5.3e-23 81.8 0.1 6.7e-23 81.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91170.1 - 1.5e-08 34.8 0.2 2e-08 34.3 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG91170.1 - 0.00014 21.4 0.1 0.00023 20.7 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG91170.1 - 0.0002 21.3 0.1 0.00061 19.7 0.1 1.8 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG91170.1 - 0.12 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Fer2_3 PF13085.6 CRG91171.1 - 1e-31 109.1 0.0 1.6e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 CRG91171.1 - 1e-08 35.6 6.7 1e-08 35.6 6.7 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 CRG91171.1 - 8.3e-07 29.0 3.8 8.3e-07 29.0 3.8 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 CRG91171.1 - 8.9e-07 29.3 8.9 8.9e-07 29.3 8.9 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 CRG91171.1 - 0.0074 16.8 5.9 0.0074 16.8 5.9 2.4 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 CRG91171.1 - 0.013 15.4 0.4 0.013 15.4 0.4 2.2 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain SF3a60_bindingd PF12108.8 CRG91171.1 - 0.13 12.2 0.4 0.22 11.5 0.4 1.4 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain Fer4_18 PF13746.6 CRG91171.1 - 0.35 11.1 6.6 0.53 10.5 0.1 2.7 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 CRG91171.1 - 1.6 9.0 11.7 30 4.9 5.2 3.0 2 1 2 4 4 4 0 4Fe-4S dicluster domain Methyltransf_23 PF13489.6 CRG91173.1 - 2.9e-23 82.5 0.0 4.2e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG91173.1 - 1.3e-12 48.2 0.0 2.5e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG91173.1 - 2.1e-09 37.9 0.0 3.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91173.1 - 1.4e-08 34.6 0.0 1.1e-07 31.8 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG91173.1 - 2.6e-06 28.1 0.0 8.3e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CRG91173.1 - 0.0016 17.9 0.0 0.0029 17.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 CRG91173.1 - 0.0027 17.5 0.0 0.004 16.9 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 CRG91173.1 - 0.0043 17.2 0.0 0.007 16.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 CRG91173.1 - 0.0064 16.1 0.0 0.053 13.1 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 CRG91173.1 - 0.024 13.9 0.0 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 CRG91173.1 - 0.086 12.2 0.0 0.5 9.7 0.0 2.1 2 1 0 2 2 2 0 ubiE/COQ5 methyltransferase family F_bP_aldolase PF01116.20 CRG91174.1 - 5.9e-85 285.1 0.4 7.2e-85 284.9 0.4 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II NAD_binding_11 PF14833.6 CRG91175.1 - 2.8e-42 143.8 0.9 2.8e-29 101.8 0.1 2.2 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 CRG91175.1 - 6.3e-37 127.2 0.2 1.4e-36 126.1 0.2 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 CRG91175.1 - 0.002 18.6 0.9 0.0081 16.7 0.1 2.4 2 1 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 CRG91175.1 - 0.0021 18.0 1.2 0.0026 17.7 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CRG91175.1 - 0.0041 16.5 0.0 0.0076 15.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.8 CRG91175.1 - 0.099 12.4 1.2 0.42 10.4 0.2 2.4 3 0 0 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase UDPG_MGDP_dh PF00984.19 CRG91175.1 - 0.11 12.8 0.3 8.6 6.6 0.0 2.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain DUF2500 PF10694.9 CRG91176.1 - 0.0034 17.9 0.0 0.008 16.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2500) PIG-P PF08510.12 CRG91176.1 - 0.0075 16.2 0.2 4.7 7.2 0.3 2.5 2 1 1 3 3 3 2 PIG-P Herpes_glycop PF01528.16 CRG91176.1 - 0.0077 15.1 0.0 0.011 14.6 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus glycoprotein M Tmemb_9 PF05434.11 CRG91176.1 - 0.0093 15.9 0.0 0.017 15.0 0.0 1.4 1 0 0 1 1 1 1 TMEM9 Ctr PF04145.15 CRG91176.1 - 0.013 16.1 0.0 0.016 15.8 0.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family DUF4381 PF14316.6 CRG91176.1 - 0.031 14.5 0.0 0.065 13.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF4834 PF16118.5 CRG91176.1 - 0.037 15.0 0.2 0.083 13.9 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CBF PF03914.17 CRG91176.1 - 0.046 13.7 0.0 0.072 13.1 0.0 1.2 1 0 0 1 1 1 0 CBF/Mak21 family DUF2621 PF11084.8 CRG91176.1 - 0.094 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) DUF719 PF05334.13 CRG91176.1 - 0.71 10.0 3.3 1.2 9.3 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Git3 PF11710.8 CRG91177.1 - 8.7e-27 94.2 12.7 2.2e-26 92.9 12.7 1.6 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 CRG91177.1 - 6.8e-16 58.1 0.1 2.3e-15 56.4 0.1 1.9 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term Ank_2 PF12796.7 CRG91178.1 - 6e-62 206.2 13.5 7.6e-11 42.5 0.1 10.1 3 3 6 10 10 10 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG91178.1 - 7.2e-57 189.1 17.0 6.3e-09 36.2 0.3 13.7 5 4 7 14 14 14 12 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG91178.1 - 1.7e-43 141.6 23.7 0.0019 18.6 0.1 17.9 19 0 0 19 19 19 9 Ankyrin repeat Ank PF00023.30 CRG91178.1 - 2.6e-30 103.5 26.2 0.0034 17.8 0.0 15.8 16 0 0 16 16 16 7 Ankyrin repeat Ank_5 PF13857.6 CRG91178.1 - 3.4e-21 75.0 21.3 0.021 15.1 0.0 12.6 8 3 6 15 15 15 9 Ankyrin repeats (many copies) Clr5 PF14420.6 CRG91178.1 - 4.9e-16 58.7 1.6 1.1e-15 57.6 1.6 1.6 1 0 0 1 1 1 1 Clr5 domain Shigella_OspC PF06128.11 CRG91178.1 - 0.082 12.6 0.0 30 4.2 0.0 4.2 3 2 2 5 5 5 0 Shigella flexneri OspC protein TPR_22 PF18833.1 CRG91178.1 - 0.25 11.5 1.9 14 5.9 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Acyl-CoA_dh_M PF02770.19 CRG91181.1 - 0.0016 18.6 0.0 0.0053 16.9 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 CRG91181.1 - 0.0055 16.9 0.1 0.011 15.9 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain G_glu_transpept PF01019.21 CRG91183.1 - 1.3e-167 558.7 0.0 1.5e-167 558.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase GST_N_3 PF13417.6 CRG91184.1 - 3.1e-13 49.9 0.0 1.7e-12 47.6 0.0 2.1 2 1 1 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG91184.1 - 1.2e-11 44.7 0.0 1.8e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG91184.1 - 6.3e-11 42.4 0.0 1.2e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 CRG91184.1 - 1.5e-08 34.8 0.0 4.3e-08 33.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG91184.1 - 6.5e-07 29.6 0.1 3.5e-06 27.2 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG91184.1 - 3.8e-06 26.8 0.3 9.1e-06 25.6 0.1 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 CRG91184.1 - 0.0014 19.2 0.0 0.0096 16.5 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 CRG91185.1 - 7.2e-11 41.6 40.2 1.2e-10 40.8 37.4 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily UxuA PF03786.13 CRG91185.1 - 0.22 10.3 0.0 0.3 9.9 0.0 1.1 1 0 0 1 1 1 0 D-mannonate dehydratase (UxuA) OATP PF03137.20 CRG91185.1 - 6.5 4.9 18.0 0.59 8.3 6.1 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family SLX9 PF15341.6 CRG91186.1 - 3.2e-35 121.4 10.2 4.5e-35 120.9 10.2 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 NAD_Gly3P_dh_N PF01210.23 CRG91187.1 - 3.2e-46 157.2 0.0 5.9e-46 156.3 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 CRG91187.1 - 3.3e-43 147.4 0.2 5.1e-43 146.8 0.2 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus Pox_VLTF3 PF04947.14 CRG91187.1 - 0.021 14.6 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 Poxvirus Late Transcription Factor VLTF3 like hDGE_amylase PF14701.6 CRG91188.1 - 2.6e-185 616.7 0.1 3.4e-185 616.3 0.1 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 CRG91188.1 - 7.1e-119 397.2 0.0 1.2e-118 396.4 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 CRG91188.1 - 6e-88 294.8 0.0 9.1e-88 294.2 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 CRG91188.1 - 2.6e-30 104.4 0.0 6.7e-30 103.1 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 CRG91188.1 - 0.0012 18.5 0.2 0.0027 17.3 0.2 1.6 1 0 0 1 1 1 1 Alpha amylase, catalytic domain Hemerythrin PF01814.23 CRG91189.1 - 6.5e-14 52.7 1.5 9.1e-14 52.2 1.5 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF2205 PF10224.9 CRG91189.1 - 0.083 12.9 0.4 14 5.8 0.3 2.6 2 0 0 2 2 2 0 Short coiled-coil protein Glyco_hydro_31 PF01055.26 CRG91190.1 - 5e-140 467.6 6.0 5e-140 467.6 6.0 1.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG91190.1 - 1e-28 99.9 0.1 2.9e-28 98.4 0.1 1.8 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG91190.1 - 1.4e-11 44.5 0.3 4.7e-11 42.8 0.3 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like F-box-like PF12937.7 CRG91191.1 - 0.00011 22.0 0.1 0.00029 20.7 0.1 1.7 1 0 0 1 1 1 1 F-box-like RSN1_7TM PF02714.15 CRG91192.1 - 1.8e-77 260.3 20.1 3.4e-77 259.4 20.1 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 CRG91192.1 - 2.3e-43 148.5 0.0 3.3e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 CRG91192.1 - 2.5e-37 128.1 0.5 1.2e-36 125.8 0.5 2.3 1 0 0 1 1 1 1 Late exocytosis, associated with Golgi transport Anoctamin PF04547.12 CRG91192.1 - 0.0042 16.0 1.2 0.0042 16.0 1.2 2.2 2 0 0 2 2 2 1 Calcium-activated chloride channel Tetraspanin PF00335.20 CRG91192.1 - 0.79 9.4 4.1 2.5 7.8 4.1 1.9 1 0 0 1 1 1 0 Tetraspanin family Glyoxalase PF00903.25 CRG91193.1 - 1.4e-12 47.9 0.6 3.3e-12 46.7 0.6 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 CRG91193.1 - 7e-06 26.3 0.0 2.1e-05 24.7 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 CRG91193.1 - 0.091 12.7 0.4 9.2 6.2 0.2 3.1 2 1 0 2 2 2 0 Glyoxalase-like domain Glyoxalase_3 PF13468.6 CRG91193.1 - 0.13 12.4 0.0 1.8 8.6 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain DAHP_synth_1 PF00793.20 CRG91194.1 - 1.9e-104 348.4 0.0 2.3e-104 348.1 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family HrcA_DNA-bdg PF03444.15 CRG91195.1 - 0.052 13.2 0.3 0.12 12.0 0.3 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF2145 PF09916.9 CRG91196.1 - 0.07 12.8 0.1 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2145) GMC_oxred_N PF00732.19 CRG91197.1 - 2.4e-56 191.3 0.0 3.1e-56 190.9 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG91197.1 - 9.8e-35 120.2 0.0 1.9e-34 119.3 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 CRG91197.1 - 1.6e-05 25.0 0.4 3.9e-05 23.8 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG91197.1 - 2.6e-05 24.0 3.2 9.6e-05 22.1 3.1 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG91197.1 - 3e-05 23.2 0.8 6.9e-05 22.1 0.2 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CRG91197.1 - 0.0012 18.0 0.7 0.03 13.4 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG91197.1 - 0.0016 17.7 0.9 0.041 13.1 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG91197.1 - 0.022 13.6 0.1 0.032 13.1 0.1 1.2 1 0 0 1 1 1 0 Tryptophan halogenase TrkA_N PF02254.18 CRG91197.1 - 0.039 14.2 0.7 0.11 12.8 0.1 2.0 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_9 PF13454.6 CRG91197.1 - 0.15 12.0 0.2 0.33 10.9 0.2 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG91197.1 - 0.17 11.1 0.8 16 4.6 0.6 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG91197.1 - 0.24 10.6 1.0 0.44 9.7 0.1 1.8 2 0 0 2 2 2 0 Thi4 family AIG2_2 PF13772.6 CRG91198.1 - 4.5e-06 27.0 0.0 1.8e-05 25.1 0.0 2.0 1 1 0 1 1 1 1 AIG2-like family Cytochrom_C1 PF02167.15 CRG91199.1 - 1.6e-92 309.2 0.0 2e-92 308.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 CRG91199.1 - 0.0086 16.4 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Phi-29_GP3 PF05435.11 CRG91199.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 Cytochrom_C PF00034.21 CRG91199.1 - 0.14 13.3 0.5 0.92 10.7 0.2 2.5 3 1 0 3 3 3 0 Cytochrome c Sec10 PF07393.11 CRG91200.1 - 4.7e-162 541.0 0.0 6.4e-162 540.6 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 CAP PF00188.26 CRG91200.1 - 1.9e-21 77.2 5.0 5.3e-21 75.8 5.0 1.8 1 0 0 1 1 1 1 Cysteine-rich secretory protein family F-box-like PF12937.7 CRG91200.1 - 6.4e-06 26.0 0.0 1.9e-05 24.5 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG91200.1 - 0.00025 20.8 0.0 0.00054 19.8 0.0 1.5 1 0 0 1 1 1 1 F-box domain Arena_RNA_pol PF06317.11 CRG91200.1 - 0.088 10.0 0.2 0.14 9.3 0.2 1.2 1 0 0 1 1 1 0 Arenavirus RNA polymerase F-box_4 PF15966.5 CRG91200.1 - 0.1 12.5 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 F-box WD40 PF00400.32 CRG91201.1 - 8.2e-56 184.7 23.4 7.4e-10 39.3 0.0 9.0 8 1 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG91201.1 - 2.6e-24 85.3 2.0 0.00034 20.8 0.0 6.6 3 3 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG91201.1 - 1.7e-07 31.3 0.1 0.0095 15.8 0.0 3.5 3 2 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CRG91201.1 - 7e-07 28.5 0.2 0.12 11.3 0.0 4.0 3 2 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 CRG91201.1 - 1.6e-06 27.1 4.4 0.56 8.8 0.0 5.4 3 3 3 6 6 6 3 Nucleoporin Nup120/160 NLE PF08154.12 CRG91201.1 - 4.9e-06 27.0 0.0 9.5e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain WD40_like PF17005.5 CRG91201.1 - 0.00049 19.5 0.0 6.8 5.9 0.0 4.1 3 2 2 5 5 5 2 WD40-like domain DUF4550 PF15084.6 CRG91201.1 - 0.024 15.1 0.1 0.14 12.6 0.1 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4550) Nbas_N PF15492.6 CRG91201.1 - 0.029 13.7 0.4 8.9 5.5 0.0 3.6 3 2 2 5 5 5 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 CRG91201.1 - 0.041 13.8 0.1 24 5.0 0.0 3.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 CRG91201.1 - 0.046 13.7 0.2 21 5.2 0.0 4.3 5 0 0 5 5 5 0 PQQ enzyme repeat FAD_binding_9 PF08021.11 CRG91201.1 - 0.074 13.3 0.0 0.91 9.7 0.0 2.4 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain MutS_V PF00488.21 CRG91202.1 - 5.3e-61 205.9 0.5 9.5e-61 205.1 0.5 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CRG91202.1 - 3.3e-34 118.8 2.4 7.8e-34 117.6 2.4 1.7 1 0 0 1 1 1 1 MutS domain III MutS_II PF05188.17 CRG91202.1 - 1e-10 42.0 0.0 2.5e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 CRG91202.1 - 1.9e-09 37.8 0.0 3.7e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 MutS family domain IV AAA_30 PF13604.6 CRG91202.1 - 0.02 14.6 0.1 0.051 13.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain SWIB PF02201.18 CRG91203.1 - 1.8e-26 91.8 0.0 6e-26 90.1 0.0 2.0 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 CRG91203.1 - 6.4e-10 38.8 0.2 1.5e-09 37.7 0.2 1.6 1 0 0 1 1 1 1 DEK C terminal domain zf-C3HC4_3 PF13920.6 CRG91203.1 - 1.1e-06 28.3 8.9 1.1e-06 28.3 8.9 3.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) Vps51 PF08700.11 CRG91203.1 - 0.14 12.2 0.2 0.35 11.0 0.1 1.7 2 0 0 2 2 2 0 Vps51/Vps67 zf-C3HC4_2 PF13923.6 CRG91203.1 - 2 8.3 21.9 0.016 15.1 10.8 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pox_Ag35 PF03286.14 CRG91203.1 - 5 6.9 8.7 8.4 6.1 7.5 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein eIF2A PF08662.11 CRG91204.1 - 7.9e-36 123.8 1.2 4.1e-32 111.6 0.5 3.5 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 CRG91204.1 - 1.1e-08 34.8 0.0 2.6e-08 33.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 CRG91204.1 - 0.00097 19.9 1.0 0.92 10.5 0.1 4.9 5 1 0 5 5 5 1 WD domain, G-beta repeat Lyase_1 PF00206.20 CRG91204.1 - 0.22 10.9 0.5 0.41 10.0 0.3 1.5 1 1 0 1 1 1 0 Lyase Velvet PF11754.8 CRG91205.1 - 1.3e-94 316.9 0.0 1.6e-94 316.6 0.0 1.0 1 0 0 1 1 1 1 Velvet factor DUF2076 PF09849.9 CRG91205.1 - 6.8 6.7 7.8 10 6.1 7.8 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PEP_mutase PF13714.6 CRG91209.1 - 1.4e-05 24.7 0.0 4.3e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Macoilin PF09726.9 CRG91210.1 - 0.44 9.0 5.1 0.47 9.0 5.1 1.0 1 0 0 1 1 1 0 Macoilin family HALZ PF02183.18 CRG91212.1 - 0.0012 19.0 1.4 0.0022 18.2 1.4 1.4 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.15 CRG91212.1 - 0.008 15.9 1.3 0.015 15.0 1.3 1.3 1 0 0 1 1 1 1 Septum formation initiator bZIP_2 PF07716.15 CRG91212.1 - 0.01 15.9 0.7 0.016 15.2 0.7 1.3 1 0 0 1 1 1 0 Basic region leucine zipper KASH_CCD PF14662.6 CRG91212.1 - 0.012 15.4 0.2 0.017 15.0 0.2 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Leu_zip PF15294.6 CRG91212.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Leucine zipper Shugoshin_N PF07558.11 CRG91212.1 - 0.056 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region Mto2_bdg PF12808.7 CRG91212.1 - 0.094 13.0 0.7 0.16 12.3 0.7 1.3 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region bZIP_1 PF00170.21 CRG91212.1 - 0.12 12.5 0.7 0.21 11.7 0.7 1.3 1 0 0 1 1 1 0 bZIP transcription factor DUF1640 PF07798.11 CRG91212.1 - 0.13 12.3 0.7 0.2 11.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF3602 PF12223.8 CRG91213.1 - 7.6e-16 58.5 9.6 2.5e-11 44.0 1.7 2.7 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Fungal_trans_2 PF11951.8 CRG91214.1 - 7.4e-53 179.7 2.1 1.1e-52 179.2 2.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91214.1 - 1.4e-07 31.5 5.5 3.6e-07 30.2 5.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pam17 PF08566.10 CRG91215.1 - 6.9e-68 227.7 0.4 1.6e-67 226.5 0.0 1.9 2 0 0 2 2 2 1 Mitochondrial import protein Pam17 Far-17a_AIG1 PF04750.14 CRG91215.1 - 2.8e-54 183.5 10.9 4e-54 183.0 10.9 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Aminotran_5 PF00266.19 CRG91216.1 - 5.8e-16 58.4 0.0 8.2e-16 57.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CRG91216.1 - 0.00023 20.5 0.0 0.0003 20.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CRG91216.1 - 0.0013 17.4 0.0 0.0017 16.9 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SepSecS PF05889.13 CRG91216.1 - 0.013 14.2 0.1 0.02 13.6 0.1 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Git3 PF11710.8 CRG91217.1 - 2.7e-26 92.6 8.7 1.1e-25 90.7 8.7 1.9 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 CRG91217.1 - 5.6e-12 45.6 0.2 1.5e-11 44.2 0.2 1.7 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 C-term 7tm_1 PF00001.21 CRG91217.1 - 0.0051 16.2 5.3 0.0074 15.6 5.2 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MFS_1 PF07690.16 CRG91219.1 - 2.1e-34 119.0 26.8 3.2e-34 118.4 26.8 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Chromate_transp PF02417.15 CRG91221.1 - 1.3e-37 129.3 28.4 9.7e-35 120.0 16.0 2.6 3 0 0 3 3 3 2 Chromate transporter Transposase_23 PF03017.14 CRG91221.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 TNP1/EN/SPM transposase His_Phos_1 PF00300.22 CRG91222.1 - 8.3e-18 64.8 0.0 9.8e-17 61.3 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF1409 PF07197.12 CRG91222.1 - 0.14 12.0 0.3 0.47 10.4 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) Aldo_ket_red PF00248.21 CRG91223.1 - 4.5e-22 78.6 0.0 1.1e-21 77.3 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Epimerase PF01370.21 CRG91224.1 - 3e-05 23.6 0.0 4.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG91224.1 - 0.0041 16.3 0.0 0.077 12.1 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein PEX11 PF05648.14 CRG91225.1 - 2.9e-23 82.5 0.0 3.7e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) AA_permease PF00324.21 CRG91226.1 - 1.7e-96 323.7 45.6 2e-96 323.5 45.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG91226.1 - 5.2e-22 78.3 49.5 7.7e-22 77.7 49.5 1.2 1 0 0 1 1 1 1 Amino acid permease Peptidase_M20 PF01546.28 CRG91227.1 - 1.1e-28 100.4 0.0 1.8e-28 99.7 0.0 1.3 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 CRG91227.1 - 1.6e-12 47.3 0.1 4.3e-12 45.9 0.1 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 CRG91227.1 - 0.0089 15.7 0.0 0.028 14.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M28 Beta_elim_lyase PF01212.21 CRG91228.1 - 2.1e-80 270.1 0.0 2.6e-80 269.8 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 CRG91228.1 - 0.00045 19.5 0.0 0.0007 18.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CRG91228.1 - 0.0067 15.0 0.0 0.0095 14.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 CRG91228.1 - 0.052 12.9 0.1 1.1 8.4 0.0 2.3 2 1 1 3 3 3 0 DegT/DnrJ/EryC1/StrS aminotransferase family AAA_lid_10 PF17872.1 CRG91228.1 - 0.13 12.4 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA lid domain Peptidase_M24 PF00557.24 CRG91229.1 - 6.1e-23 81.6 0.1 8.9e-23 81.1 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 CRG91229.1 - 7.9e-18 65.4 0.0 1.7e-17 64.3 0.0 1.6 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain p450 PF00067.22 CRG91230.1 - 5.3e-50 170.5 0.0 1.1e-49 169.4 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 Fungal_trans_2 PF11951.8 CRG91230.1 - 1.2e-08 34.2 0.8 2.2e-08 33.3 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans_2 PF11951.8 CRG91231.1 - 2e-05 23.6 0.2 0.00013 21.0 0.1 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain adh_short PF00106.25 CRG91232.1 - 9.9e-29 100.2 0.0 4.8e-22 78.4 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91232.1 - 5.4e-15 55.6 0.0 1.8e-11 44.0 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91232.1 - 9.3e-07 28.9 0.0 1.6e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG91232.1 - 0.0019 17.4 0.0 0.1 11.7 0.0 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein CAP59_mtransfer PF11735.8 CRG91233.1 - 9.5e-68 228.5 0.0 1.2e-67 228.2 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Fungal_trans PF04082.18 CRG91234.1 - 3.1e-20 72.3 0.3 8.1e-20 70.9 0.0 1.8 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91234.1 - 5.1e-08 32.9 11.1 5.1e-08 32.9 11.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAM176 PF14851.6 CRG91234.1 - 0.075 12.7 0.4 0.21 11.3 0.4 1.7 1 0 0 1 1 1 0 FAM176 family Tub_N PF16322.5 CRG91235.1 - 0.25 11.7 6.3 0.32 11.4 6.3 1.3 1 0 0 1 1 1 0 Tubby N-terminal SDA1 PF05285.12 CRG91235.1 - 0.69 9.3 10.5 0.89 8.9 10.5 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 CRG91235.1 - 0.86 8.9 12.6 1 8.6 12.6 1.1 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 CRG91235.1 - 3.5 5.6 18.1 4.4 5.3 18.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi NAD_binding_1 PF00175.21 CRG91237.1 - 2.2e-15 57.2 0.0 7e-15 55.6 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Globin PF00042.22 CRG91237.1 - 7.8e-09 36.1 0.4 1.9e-08 34.8 0.1 1.9 2 0 0 2 2 2 1 Globin NAD_binding_6 PF08030.12 CRG91237.1 - 7.8e-08 32.6 0.1 1.6e-06 28.3 0.0 2.5 2 1 0 3 3 3 1 Ferric reductase NAD binding domain Protoglobin PF11563.8 CRG91237.1 - 3.4e-05 23.8 0.4 0.00013 21.9 0.4 1.9 1 1 0 1 1 1 1 Protoglobin FAD_binding_6 PF00970.24 CRG91237.1 - 6.3e-05 23.2 0.0 0.00013 22.2 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain FAD_binding_8 PF08022.12 CRG91237.1 - 0.043 13.9 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 FAD-binding domain Asp PF00026.23 CRG91238.1 - 1.2e-68 231.8 9.0 1.8e-68 231.3 9.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG91238.1 - 5.1e-07 30.1 1.2 0.00017 21.9 0.5 2.8 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG91238.1 - 0.007 17.0 1.6 0.21 12.2 0.2 3.1 2 1 0 2 2 2 1 Aspartyl protease Med27 PF11571.8 CRG91238.1 - 0.097 13.0 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 Mediator complex subunit 27 zinc_ribbon_10 PF10058.9 CRG91239.1 - 0.16 11.7 0.1 0.33 10.7 0.1 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein DUF3482 PF11981.8 CRG91239.1 - 6 6.2 5.2 9 5.6 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) SNF2_N PF00176.23 CRG91241.1 - 3.6e-66 223.3 0.0 6.5e-66 222.4 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG91241.1 - 2e-17 63.6 0.0 4.7e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG91241.1 - 6.3e-08 32.8 0.0 1.9e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TFIIF_beta PF02270.15 CRG91241.1 - 0.024 14.8 0.0 0.076 13.2 0.0 1.9 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain FtsL PF04999.13 CRG91241.1 - 0.078 13.0 1.7 0.18 11.8 1.7 1.6 1 0 0 1 1 1 0 Cell division protein FtsL NINJA_B PF16136.5 CRG91241.1 - 4.5 7.7 9.9 4.3 7.7 1.8 3.4 3 0 0 3 3 3 0 Putative nuclear localisation signal Pkinase PF00069.25 CRG91242.1 - 1.8e-50 171.8 0.2 1.1e-49 169.2 0.2 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91242.1 - 2.3e-23 82.8 0.0 4.7e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CRG91242.1 - 0.00038 20.5 1.4 0.00055 19.9 0.1 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 CRG91242.1 - 0.0049 16.5 0.3 0.02 14.5 0.3 1.8 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 CRG91242.1 - 0.35 10.4 3.8 0.49 9.9 0.2 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase eIF-3c_N PF05470.12 CRG91243.1 - 3.5e-177 590.3 19.4 3.5e-177 590.3 19.4 3.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 CRG91243.1 - 8.6e-14 51.9 0.3 1.6e-12 47.9 0.0 3.0 2 1 0 2 2 2 1 PCI domain DUF1385 PF07136.11 CRG91243.1 - 0.0093 15.3 0.0 0.034 13.5 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1385) DUF3713 PF12506.8 CRG91243.1 - 0.18 12.1 3.7 1.3 9.4 2.0 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3713) SKI PF01202.22 CRG91243.1 - 1.2 9.3 4.5 0.85 9.7 0.1 3.0 4 1 0 4 4 4 0 Shikimate kinase CDC45 PF02724.14 CRG91243.1 - 3.5 5.8 15.9 5.5 5.2 15.9 1.3 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 CRG91243.1 - 8.7 5.7 26.8 17 4.7 26.8 1.4 1 0 0 1 1 1 0 SDA1 EAP30 PF04157.16 CRG91244.1 - 6.7e-72 241.6 0.0 7.6e-72 241.4 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family MarR PF01047.22 CRG91244.1 - 0.045 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 MarR family MarR_2 PF12802.7 CRG91244.1 - 0.063 13.2 0.1 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 MarR family Ribosomal_L30_N PF08079.12 CRG91245.1 - 8.9e-27 93.2 15.0 1.4e-26 92.6 15.0 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 CRG91245.1 - 1.5e-16 60.0 1.5 1.5e-16 60.0 1.5 2.0 3 0 0 3 3 3 1 Ribosomal protein L30p/L7e Amidinotransf PF02274.17 CRG91245.1 - 0.088 11.9 0.2 0.17 10.9 0.2 1.4 1 0 0 1 1 1 0 Amidinotransferase PRK PF00485.18 CRG91246.1 - 0.016 14.9 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family TsaE PF02367.17 CRG91246.1 - 0.019 14.9 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 CRG91246.1 - 0.056 14.0 0.0 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain adh_short PF00106.25 CRG91247.1 - 2.4e-82 275.1 9.3 4e-44 150.4 1.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91247.1 - 6e-66 222.4 6.3 5.1e-35 121.1 0.5 2.4 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 CRG91247.1 - 2e-33 114.6 0.0 3.5e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 CRG91247.1 - 8.4e-27 94.2 5.0 1.6e-12 47.7 0.4 2.7 2 1 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 CRG91247.1 - 0.00079 18.8 0.1 0.0099 15.2 0.2 2.3 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DUF4574 PF15141.6 CRG91247.1 - 0.45 10.5 1.6 2.2 8.2 0.1 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 3HCDH_N PF02737.18 CRG91247.1 - 2.9 7.7 4.8 34 4.3 0.9 3.3 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain RhoGAP PF00620.27 CRG91248.1 - 7.7e-30 103.7 0.0 1.3e-29 103.0 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Prenyltrans PF00432.21 CRG91249.1 - 7.7e-48 159.9 2.9 5.6e-10 38.8 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CRG91249.1 - 0.00036 19.7 0.0 0.31 10.1 0.0 3.0 2 1 1 3 3 3 2 Squalene-hopene cyclase N-terminal domain MutS_V PF00488.21 CRG91250.1 - 1.1e-75 253.8 0.1 2.3e-75 252.8 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CRG91250.1 - 4.7e-36 124.8 1.7 4.7e-36 124.8 1.7 2.3 2 1 0 2 2 2 1 MutS domain III MutS_I PF01624.20 CRG91250.1 - 2.1e-30 105.2 0.1 6.7e-30 103.6 0.1 1.9 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CRG91250.1 - 2.3e-10 40.9 0.5 1.3e-09 38.4 0.0 2.6 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 CRG91250.1 - 0.00027 21.2 3.1 0.00034 20.9 0.1 2.7 3 0 0 3 3 3 1 MutS family domain IV DUF4911 PF16256.5 CRG91250.1 - 0.052 13.5 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4911) ATPase_2 PF01637.18 CRG91250.1 - 0.13 12.2 0.9 1.3 8.9 0.1 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea PPP4R2 PF09184.11 CRG91250.1 - 0.58 9.7 11.5 1.5 8.3 11.5 1.7 1 0 0 1 1 1 0 PPP4R2 adh_short_C2 PF13561.6 CRG91251.1 - 1.2e-10 41.4 0.0 1.9e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91251.1 - 1.7e-10 40.7 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Pyr_redox_2 PF07992.14 CRG91251.1 - 0.0052 16.1 0.0 0.0059 15.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 CRG91251.1 - 0.021 14.2 0.1 0.032 13.6 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 CRG91251.1 - 0.057 13.3 0.1 0.081 12.8 0.1 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 CRG91251.1 - 0.23 10.5 0.4 0.3 10.1 0.4 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Fungal_trans_2 PF11951.8 CRG91252.1 - 0.055 12.3 0.9 0.083 11.7 0.3 1.5 2 0 0 2 2 2 0 Fungal specific transcription factor domain HisG PF01634.18 CRG91253.1 - 6.3e-55 185.5 0.4 9.2e-55 185.0 0.4 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 CRG91253.1 - 2.6e-27 94.8 0.6 2.6e-27 94.8 0.6 1.7 2 0 0 2 2 2 1 HisG, C-terminal domain ADH_N_2 PF16884.5 CRG91254.1 - 2.6e-22 78.7 0.0 5.6e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CRG91254.1 - 1.5e-19 70.3 0.0 2.9e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG91254.1 - 4.3e-07 31.0 0.0 8.2e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Abhydrolase_6 PF12697.7 CRG91257.1 - 0.0062 17.2 0.0 0.02 15.5 0.0 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG91257.1 - 0.028 13.7 0.0 0.061 12.6 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 CRG91257.1 - 0.075 12.7 0.2 0.27 10.9 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 CRG91257.1 - 0.13 12.2 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase LCAT PF02450.15 CRG91257.1 - 0.16 11.1 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF2235 PF09994.9 CRG91258.1 - 7.6e-74 248.6 0.0 1.1e-73 248.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Fungal_trans_2 PF11951.8 CRG91258.1 - 4.2e-11 42.3 2.7 2.4e-10 39.8 2.7 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91258.1 - 1.6e-08 34.5 10.4 5e-08 32.9 10.4 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_3 PF13738.6 CRG91259.1 - 2.4e-19 69.7 0.0 2.8e-16 59.7 0.0 2.6 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 CRG91259.1 - 8e-17 60.8 0.1 4.5e-14 51.8 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG91259.1 - 1.5e-15 57.2 0.0 3.9e-13 49.3 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG91259.1 - 2.7e-09 36.6 0.1 1.2e-06 27.9 0.0 3.3 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 CRG91259.1 - 8.8e-07 29.4 0.1 0.073 13.6 0.0 2.8 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG91259.1 - 3.8e-06 27.0 0.0 2e-05 24.7 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 CRG91259.1 - 0.00017 21.0 0.0 0.029 13.7 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 CRG91259.1 - 0.00023 20.7 0.0 0.011 15.4 0.0 2.3 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 CRG91259.1 - 0.00053 20.5 0.0 0.012 16.2 0.0 2.5 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent FAD_binding_3 PF01494.19 CRG91259.1 - 0.00085 18.7 0.0 0.06 12.6 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Shikimate_DH PF01488.20 CRG91259.1 - 0.0011 19.1 0.0 0.74 9.9 0.0 2.6 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 CRG91259.1 - 0.011 15.6 0.0 0.35 10.7 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 CRG91259.1 - 0.017 15.4 0.1 3.3 8.0 0.0 2.4 2 0 0 2 2 2 0 TrkA-N domain HI0933_like PF03486.14 CRG91259.1 - 0.051 12.3 0.1 0.16 10.6 0.0 1.9 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.6 CRG91259.1 - 0.061 13.3 0.1 6.4 6.7 0.0 3.1 3 0 0 3 3 3 0 FAD-NAD(P)-binding NAD_binding_2 PF03446.15 CRG91259.1 - 0.07 13.3 0.0 5.7 7.1 0.0 2.4 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Lycopene_cycl PF05834.12 CRG91259.1 - 0.077 12.0 0.0 0.57 9.2 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Glu_dehyd_C PF16912.5 CRG91259.1 - 0.11 12.0 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus adh_short PF00106.25 CRG91259.1 - 0.19 11.2 0.1 3 7.2 0.0 2.2 2 0 0 2 2 2 0 short chain dehydrogenase COesterase PF00135.28 CRG91260.1 - 1.1e-72 245.6 0.0 1.4e-72 245.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG91260.1 - 2.7e-08 33.9 0.1 3.9e-08 33.4 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Helo_like_N PF17111.5 CRG91261.1 - 1.6e-85 285.7 11.3 6.3e-81 270.7 1.5 2.1 2 0 0 2 2 2 2 Fungal N-terminal domain of STAND proteins EAP30 PF04157.16 CRG91261.1 - 0.00037 19.9 2.2 0.0014 17.9 2.1 2.0 2 0 0 2 2 2 1 EAP30/Vps36 family PRESAN PF09687.10 CRG91261.1 - 0.011 16.3 0.2 0.024 15.2 0.2 1.5 1 0 0 1 1 1 0 Plasmodium RESA N-terminal Phage_HK97_TLTM PF06120.11 CRG91261.1 - 0.045 12.9 0.7 0.076 12.2 0.7 1.4 1 0 0 1 1 1 0 Tail length tape measure protein SesA PF17107.5 CRG91261.1 - 0.048 13.8 5.4 0.26 11.5 0.0 2.9 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1043 PF06295.12 CRG91261.1 - 0.083 12.9 4.7 0.061 13.3 1.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Goodbye PF17109.5 CRG91261.1 - 0.098 13.1 2.2 5.6 7.4 0.0 3.0 3 0 0 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF1664 PF07889.12 CRG91261.1 - 1.2 9.2 7.7 0.59 10.2 1.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) IL2 PF00715.17 CRG91261.1 - 1.6 8.6 7.0 14 5.6 0.2 3.2 3 0 0 3 3 3 0 Interleukin 2 Spc7 PF08317.11 CRG91261.1 - 5.2 5.9 16.0 2 7.3 6.2 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein COesterase PF00135.28 CRG91262.1 - 0.00011 21.2 0.1 0.00012 21.1 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family Fungal_trans PF04082.18 CRG91263.1 - 7.9e-17 61.2 0.1 1.7e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 CRG91264.1 - 0.0019 17.3 1.5 0.0043 16.1 1.5 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91264.1 - 0.019 15.1 14.3 0.03 14.4 14.3 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.24 CRG91265.1 - 2.4e-27 96.5 0.2 4.2e-27 95.6 0.2 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG91265.1 - 0.00029 20.9 0.0 0.00075 19.5 0.0 1.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CRG91265.1 - 0.027 13.7 0.3 0.085 12.1 0.0 2.0 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase UbiD PF01977.16 CRG91266.1 - 1.1e-101 340.7 0.0 1.3e-101 340.4 0.0 1.1 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase MFS_1 PF07690.16 CRG91266.1 - 1.3e-15 57.2 20.2 2.2e-15 56.4 20.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2238 PF09997.9 CRG91266.1 - 0.06 13.1 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2238) HMG_box PF00505.19 CRG91266.1 - 0.59 10.6 3.5 8.9 6.8 0.1 3.0 3 0 0 3 3 3 0 HMG (high mobility group) box Fungal_trans PF04082.18 CRG91267.1 - 7.1e-19 67.9 0.3 2.6e-18 66.0 0.1 1.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain Flavoprotein PF02441.19 CRG91267.1 - 9.4e-10 38.5 0.2 1.7e-09 37.6 0.2 1.4 1 0 0 1 1 1 1 Flavoprotein FAD_binding_2 PF00890.24 CRG91268.1 - 3.9e-36 125.1 0.0 6.4e-36 124.3 0.0 1.3 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG91268.1 - 0.003 17.2 0.0 0.0087 15.7 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG91268.1 - 0.0069 16.9 0.2 4.3 8.0 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG91268.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG91268.1 - 0.19 10.7 0.0 0.28 10.2 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Abhydrolase_6 PF12697.7 CRG91271.1 - 1.6e-07 32.2 0.1 1.9e-07 31.9 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Glyco_hydro_88 PF07470.13 CRG91272.1 - 3.3e-38 131.6 2.7 4.5e-38 131.2 2.7 1.1 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 adh_short PF00106.25 CRG91273.1 - 1.5e-41 142.0 0.0 2.4e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91273.1 - 2.9e-29 102.3 0.0 4.8e-29 101.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91273.1 - 2.5e-10 40.5 0.1 2.1e-09 37.6 0.1 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG91273.1 - 3.5e-07 29.9 0.0 5.4e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG91273.1 - 0.0027 16.8 0.1 0.0042 16.1 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family UPF0146 PF03686.13 CRG91273.1 - 0.0045 16.8 0.0 0.009 15.9 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0146) TrkA_N PF02254.18 CRG91273.1 - 0.013 15.8 0.2 0.042 14.1 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_10 PF13460.6 CRG91273.1 - 0.021 14.7 0.0 0.03 14.2 0.0 1.5 1 1 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG91273.1 - 0.042 13.3 0.1 0.092 12.1 0.1 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short_C2 PF13561.6 CRG91275.1 - 5.2e-63 212.7 0.1 5.9e-63 212.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91275.1 - 2.5e-44 151.1 0.1 3e-44 150.8 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG91275.1 - 1.3e-12 48.0 0.0 1.8e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 KR domain YjeF_N PF03853.15 CRG91275.1 - 0.1 12.5 0.1 0.36 10.7 0.1 1.9 2 1 1 3 3 3 0 YjeF-related protein N-terminus SUR7 PF06687.12 CRG91276.1 - 1.8e-27 96.3 10.5 2.5e-27 95.9 10.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF2298 PF10060.9 CRG91276.1 - 2.2 6.9 8.6 0.14 10.9 3.7 1.3 2 0 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) DUF1993 PF09351.10 CRG91277.1 - 2.8e-44 151.1 0.0 3.1e-44 150.9 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) EutA PF06277.11 CRG91277.1 - 0.00069 18.6 0.0 0.00081 18.4 0.0 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutA AAT PF03417.16 CRG91278.1 - 1.7e-25 90.0 0.0 2.5e-25 89.5 0.0 1.1 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase NAD_binding_4 PF07993.12 CRG91279.1 - 3.2e-32 111.7 0.0 1.7e-31 109.4 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 CRG91279.1 - 8.8e-30 103.6 0.0 1.5e-29 102.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 CRG91279.1 - 1.4e-09 37.8 0.0 4.1e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 CRG91279.1 - 4.5e-09 35.7 1.2 1.1e-08 34.4 0.3 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain PP-binding PF00550.25 CRG91279.1 - 6.4e-07 29.6 0.2 1.6e-06 28.3 0.2 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 CRG91279.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 KR domain Ion_trans_2 PF07885.16 CRG91280.1 - 7.3e-27 93.2 26.9 9.4e-16 57.5 7.3 3.8 4 0 0 4 4 4 2 Ion channel Na_Ala_symp PF01235.17 CRG91280.1 - 0.003 16.9 1.1 0.0064 15.9 0.6 1.8 1 1 1 2 2 2 1 Sodium:alanine symporter family DUF2569 PF10754.9 CRG91280.1 - 9.9 6.6 12.5 0.26 11.7 4.4 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2569) SKG6 PF08693.10 CRG91281.1 - 0.0015 17.9 0.8 0.0029 17.0 0.8 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain EphA2_TM PF14575.6 CRG91281.1 - 0.015 16.1 0.0 0.051 14.5 0.0 1.9 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF3328 PF11807.8 CRG91281.1 - 4.9 6.9 7.2 12 5.6 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3328) SNARE PF05739.19 CRG91282.1 - 1.8e-13 50.3 1.9 2.3e-13 49.9 0.1 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 CRG91282.1 - 3.5e-11 42.0 0.1 7.9e-11 40.9 0.1 1.7 1 0 0 1 1 1 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin-18_N PF10496.9 CRG91282.1 - 0.00044 20.4 1.3 0.0059 16.8 0.1 2.7 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus Syntaxin PF00804.25 CRG91282.1 - 0.00078 19.2 5.9 0.0023 17.6 0.0 3.1 2 1 1 3 3 3 1 Syntaxin KxDL PF10241.9 CRG91282.1 - 0.0035 17.6 4.7 0.83 10.0 0.1 3.3 4 0 0 4 4 4 2 Uncharacterized conserved protein DUF4988 PF16378.5 CRG91282.1 - 0.045 13.4 4.7 6.6 6.4 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function NPV_P10 PF05531.12 CRG91282.1 - 0.35 11.4 4.5 16 6.1 0.1 3.8 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Abhydrolase_1 PF00561.20 CRG91283.1 - 1.6e-11 44.4 0.1 2.8e-11 43.6 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG91283.1 - 5e-06 27.3 0.0 7.4e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG91283.1 - 1.6e-05 24.3 0.1 3.3e-05 23.3 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CRG91283.1 - 0.084 13.0 0.1 0.17 12.0 0.1 1.5 1 1 0 1 1 1 0 Thioesterase domain HAD_2 PF13419.6 CRG91284.1 - 7.4e-14 52.2 0.0 1e-13 51.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 CRG91284.1 - 4.3e-08 33.7 0.0 9.7e-08 32.5 0.0 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase TFA2_Winged_2 PF18121.1 CRG91284.1 - 0.0016 18.1 0.0 0.0064 16.2 0.0 2.0 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 Hydrolase_6 PF13344.6 CRG91284.1 - 0.0032 17.5 0.0 0.0061 16.6 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG91284.1 - 0.0083 16.2 0.1 0.015 15.4 0.1 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like DNA_pol_D_N PF18018.1 CRG91284.1 - 0.075 13.1 0.0 0.084 13.0 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain Glyoxalase_4 PF13669.6 CRG91284.1 - 0.1 12.9 0.1 0.47 10.7 0.0 1.9 2 0 0 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily adh_short_C2 PF13561.6 CRG91285.1 - 2.6e-53 181.0 0.0 4e-53 180.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91285.1 - 7.4e-42 143.0 0.0 1.2e-41 142.3 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG91285.1 - 2.6e-08 34.0 0.0 4.8e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 KR domain ABC1 PF03109.16 CRG91286.1 - 1.9e-21 76.4 0.0 2.2e-20 73.0 0.0 2.3 2 0 0 2 2 2 1 ABC1 family APH PF01636.23 CRG91286.1 - 0.024 14.6 0.2 0.1 12.5 0.1 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family TPMT PF05724.11 CRG91286.1 - 0.026 14.2 0.0 0.39 10.3 0.0 2.4 2 0 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) p450 PF00067.22 CRG91287.1 - 7.2e-61 206.3 0.0 9.7e-61 205.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF4698 PF15769.5 CRG91287.1 - 0.11 11.6 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Lactamase_B PF00753.27 CRG91288.1 - 2.4e-06 27.7 0.8 0.00029 20.9 0.3 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG91288.1 - 0.0042 16.6 0.6 0.011 15.3 0.1 1.9 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 CRG91288.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain FAD_binding_3 PF01494.19 CRG91289.1 - 1.1e-15 57.8 0.1 5.2e-15 55.5 0.1 2.0 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 CRG91289.1 - 9.4e-05 21.6 0.0 0.016 14.3 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase DAO PF01266.24 CRG91289.1 - 0.00021 21.0 0.0 0.29 10.7 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91289.1 - 0.099 12.9 0.0 0.51 10.6 0.0 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain p450 PF00067.22 CRG91290.1 - 2.4e-43 148.6 0.0 4e-43 147.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans_2 PF11951.8 CRG91290.1 - 2.4e-06 26.6 0.3 5e-06 25.6 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91290.1 - 0.042 14.0 1.4 0.096 12.8 1.4 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_11 PF14598.6 CRG91290.1 - 0.068 13.3 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 PAS domain Bcl-2 PF00452.19 CRG91290.1 - 0.11 13.2 0.6 26 5.6 0.1 2.7 2 0 0 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Abhydrolase_6 PF12697.7 CRG91292.1 - 4.5e-20 73.2 0.1 5.2e-20 73.0 0.1 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Gly_transf_sug PF04488.15 CRG91293.1 - 2.5e-12 47.3 0.2 4.7e-12 46.4 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 CRG91293.1 - 0.095 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein Glyco_hydro_cc PF11790.8 CRG91294.1 - 5.1e-57 193.2 0.2 6.2e-57 192.9 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Dodecin PF07311.12 CRG91294.1 - 0.065 13.5 0.3 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Dodecin Chlorophyllase2 PF12740.7 CRG91296.1 - 2.6e-08 33.1 0.0 4.7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_6 PF12697.7 CRG91296.1 - 3.5e-08 34.3 1.2 6.2e-06 27.0 0.2 2.3 1 1 2 3 3 3 1 Alpha/beta hydrolase family Chlorophyllase PF07224.11 CRG91296.1 - 2.1e-07 30.3 0.0 3.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase PAF-AH_p_II PF03403.13 CRG91296.1 - 9.5e-07 27.6 0.1 0.0059 15.2 0.0 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_1 PF00561.20 CRG91296.1 - 0.001 18.8 0.0 0.29 10.7 0.0 2.5 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG91296.1 - 0.0011 18.3 0.0 0.016 14.5 0.0 2.5 3 0 0 3 3 3 1 Serine aminopeptidase, S33 FSH1 PF03959.13 CRG91296.1 - 0.0011 18.7 0.0 0.0016 18.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 CRG91296.1 - 0.0041 16.8 0.0 0.007 16.0 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 CRG91296.1 - 0.0096 15.6 0.0 0.019 14.6 0.0 1.5 1 1 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 CRG91296.1 - 0.011 15.6 0.1 0.14 12.0 0.0 2.1 1 1 1 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG91296.1 - 0.012 15.1 0.0 0.2 11.1 0.1 2.2 2 1 0 2 2 2 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 CRG91296.1 - 0.068 13.0 0.4 0.13 12.2 0.0 1.6 2 0 0 2 2 2 0 Lipase (class 3) PGAP1 PF07819.13 CRG91296.1 - 0.078 12.7 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein DLH PF01738.18 CRG91296.1 - 0.094 12.3 0.0 0.62 9.6 0.0 2.1 2 1 0 2 2 2 0 Dienelactone hydrolase family Thioesterase PF00975.20 CRG91296.1 - 0.12 12.4 0.2 1.1 9.4 0.0 2.3 2 1 0 2 2 2 0 Thioesterase domain Sugar_tr PF00083.24 CRG91297.1 - 8.9e-91 305.0 26.8 1.1e-90 304.7 26.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91297.1 - 1.3e-24 86.8 27.9 1.3e-24 86.8 27.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 CRG91297.1 - 0.0016 17.1 23.0 0.0073 14.9 6.4 2.7 3 0 0 3 3 3 2 MFS/sugar transport protein Epimerase PF01370.21 CRG91298.1 - 2.7e-14 53.2 0.7 1.9e-11 43.9 0.3 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 CRG91298.1 - 5.6e-10 39.4 2.0 7.7e-10 39.0 2.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG91298.1 - 3.5e-08 33.3 0.6 3.6e-07 30.0 0.6 2.1 2 0 0 2 2 2 1 NmrA-like family 3Beta_HSD PF01073.19 CRG91298.1 - 7.3e-08 31.7 0.1 1.3e-07 31.0 0.1 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CRG91298.1 - 2.8e-07 29.9 0.1 1.4e-06 27.6 0.1 1.8 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 CRG91298.1 - 4.2e-07 29.7 0.4 4.7e-06 26.2 0.1 2.4 3 0 0 3 3 3 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CRG91298.1 - 1.3e-05 25.5 0.3 2.7e-05 24.4 0.3 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CRG91298.1 - 0.00055 20.2 0.2 0.001 19.3 0.2 1.5 1 0 0 1 1 1 1 TrkA-N domain adh_short PF00106.25 CRG91298.1 - 0.00059 19.4 0.3 0.001 18.6 0.3 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 CRG91298.1 - 0.0024 17.1 0.1 0.0038 16.4 0.1 1.3 1 0 0 1 1 1 1 Male sterility protein KR PF08659.10 CRG91298.1 - 0.011 15.7 0.7 0.023 14.6 0.7 1.6 1 0 0 1 1 1 0 KR domain DapB_N PF01113.20 CRG91298.1 - 0.025 14.7 0.4 0.053 13.6 0.4 1.7 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus MADF_DNA_bdg PF10545.9 CRG91299.1 - 0.32 11.3 0.2 0.32 11.3 0.2 2.0 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like HSP70 PF00012.20 CRG91300.1 - 1.8e-08 33.1 0.0 7.6e-06 24.4 0.0 2.9 2 1 0 2 2 2 2 Hsp70 protein DUF3764 PF12594.8 CRG91300.1 - 0.14 12.2 0.0 3.9 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) Pyrid_oxidase_2 PF13883.6 CRG91300.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase E1-E2_ATPase PF00122.20 CRG91301.1 - 1.7e-40 138.4 8.9 2.4e-40 138.0 0.1 3.5 4 1 0 4 4 4 2 E1-E2 ATPase Hydrolase PF00702.26 CRG91301.1 - 2.8e-16 60.4 0.0 1e-15 58.6 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG91301.1 - 0.00027 20.6 0.0 0.00062 19.4 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 CRG91301.1 - 0.014 15.1 0.2 0.04 13.7 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase GNVR PF13807.6 CRG91301.1 - 0.099 12.6 0.8 0.33 10.9 0.0 2.4 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Glyco_hydro_7 PF00840.20 CRG91303.1 - 6.7e-152 506.2 15.4 7.9e-152 506.0 15.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 ABC_tran PF00005.27 CRG91304.1 - 5.7e-36 124.1 0.0 6.1e-26 91.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG91304.1 - 1.2e-24 87.4 30.9 9.5e-20 71.4 13.8 2.6 2 1 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 CRG91304.1 - 1.7e-08 34.2 0.6 0.008 15.6 0.0 3.2 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 CRG91304.1 - 1e-05 25.5 0.0 0.17 11.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CRG91304.1 - 0.037 14.3 0.1 2.9 8.2 0.1 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 CRG91304.1 - 0.079 12.7 0.1 0.24 11.2 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Glyco_transf_15 PF01793.16 CRG91305.1 - 9.9e-113 376.7 10.5 1.2e-112 376.3 10.5 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase MIP PF00230.20 CRG91306.1 - 9.7e-27 94.1 5.8 1.3e-26 93.8 5.8 1.1 1 0 0 1 1 1 1 Major intrinsic protein Polysacc_lyase PF14099.6 CRG91306.1 - 0.075 12.9 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide lyase ABC_membrane PF00664.23 CRG91308.1 - 1.4e-80 270.9 35.0 2.5e-43 148.7 11.0 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG91308.1 - 7e-64 214.4 0.0 2.7e-32 112.1 0.0 3.2 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG91308.1 - 4.8e-14 52.3 0.1 0.00021 20.8 0.0 4.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 CRG91308.1 - 3.9e-09 36.9 0.3 0.0045 17.3 0.0 4.0 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 CRG91308.1 - 1.2e-08 35.5 1.1 0.00044 20.7 0.2 3.2 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 CRG91308.1 - 2e-07 31.1 0.1 0.0038 17.1 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 CRG91308.1 - 1.1e-06 29.2 0.7 1.1 9.7 0.0 4.5 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 CRG91308.1 - 1.2e-06 28.3 0.3 0.52 9.8 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_7 PF12775.7 CRG91308.1 - 4.2e-06 26.4 0.0 0.058 12.9 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region ABC_ATPase PF09818.9 CRG91308.1 - 4.6e-06 25.7 0.2 0.00081 18.3 0.1 2.8 3 0 0 3 3 3 1 Predicted ATPase of the ABC class AAA_29 PF13555.6 CRG91308.1 - 5.6e-06 26.0 1.8 0.042 13.6 0.5 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG91308.1 - 1.2e-05 25.9 0.9 0.25 11.8 0.2 2.7 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 CRG91308.1 - 1.3e-05 25.2 0.1 0.42 10.4 0.0 3.6 3 1 1 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 CRG91308.1 - 4.3e-05 23.5 0.1 0.49 10.3 0.0 2.6 3 0 0 3 3 2 2 Rad17 P-loop domain AAA_30 PF13604.6 CRG91308.1 - 8.4e-05 22.4 0.5 1.1 8.9 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_15 PF13175.6 CRG91308.1 - 0.00026 20.8 1.0 0.13 12.0 0.0 2.6 3 0 0 3 3 3 2 AAA ATPase domain AAA_18 PF13238.6 CRG91308.1 - 0.00037 21.1 0.2 1.7 9.2 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.14 CRG91308.1 - 0.00059 19.9 0.0 1.6 8.7 0.0 3.1 3 0 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CRG91308.1 - 0.0013 19.0 0.3 0.58 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 CRG91308.1 - 0.0039 17.4 1.7 1.2 9.4 0.4 3.6 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 CRG91308.1 - 0.0044 17.2 0.0 2.5 8.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CRG91308.1 - 0.0045 16.7 1.8 2 8.1 0.0 4.0 4 0 0 4 4 4 1 IstB-like ATP binding protein NB-ARC PF00931.22 CRG91308.1 - 0.0091 15.2 0.2 1.2 8.3 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain RNA_helicase PF00910.22 CRG91308.1 - 0.01 16.2 0.0 8.8 6.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATP-synt_ab PF00006.25 CRG91308.1 - 0.02 14.6 0.1 0.72 9.5 0.0 2.7 3 0 0 3 3 3 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.12 CRG91308.1 - 0.021 14.8 0.1 37 4.2 0.0 3.5 3 0 0 3 3 3 0 NACHT domain Mg_chelatase PF01078.21 CRG91308.1 - 0.044 13.2 0.0 0.92 8.8 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF3619 PF12279.8 CRG91308.1 - 0.089 13.1 0.8 0.64 10.3 0.2 2.9 2 0 0 2 2 1 0 Protein of unknown function (DUF3619) AAA_24 PF13479.6 CRG91308.1 - 0.095 12.4 0.4 16 5.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain PRK PF00485.18 CRG91308.1 - 0.11 12.2 0.2 14 5.3 0.0 2.5 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 CRG91308.1 - 0.11 12.5 0.0 37 4.3 0.0 3.3 3 0 0 3 3 3 0 AAA domain Sugar_tr PF00083.24 CRG91309.1 - 2.3e-86 290.4 27.4 2.8e-86 290.2 27.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91309.1 - 1.2e-28 100.0 23.5 3e-28 98.8 21.5 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG91309.1 - 0.00028 19.5 2.0 0.00028 19.5 2.0 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) FAD_binding_4 PF01565.23 CRG91310.1 - 1.9e-24 86.0 0.3 3.4e-24 85.1 0.3 1.4 1 0 0 1 1 1 1 FAD binding domain Thioredoxin_6 PF13848.6 CRG91311.1 - 1.5e-18 67.4 0.2 1.6e-14 54.3 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 CRG91311.1 - 3.1e-14 52.8 0.1 6.9e-11 42.1 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin 2OG-FeII_Oxy_3 PF13640.6 CRG91312.1 - 9.2e-10 39.3 0.0 1.7e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_clus PF00172.18 CRG91313.1 - 8.9e-07 28.9 15.0 1.4e-06 28.3 15.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG91313.1 - 0.012 14.7 0.4 0.023 13.8 0.4 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain Fungal_trans PF04082.18 CRG91314.1 - 2.5e-25 89.0 0.0 4.9e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91314.1 - 1.7e-06 28.1 9.3 2.7e-06 27.4 9.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Hydantoinase_B PF02538.14 CRG91315.1 - 3.8e-208 692.1 0.2 4.9e-208 691.7 0.2 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 CRG91315.1 - 2.1e-90 302.9 0.0 3.8e-90 302.1 0.0 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 CRG91315.1 - 1.3e-56 191.1 0.0 5.1e-55 185.9 0.0 2.4 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase N-terminal region Pectinesterase PF01095.19 CRG91316.1 - 2.3e-23 82.4 0.2 1.6e-19 69.7 0.7 2.1 2 0 0 2 2 2 2 Pectinesterase FAD_binding_2 PF00890.24 CRG91317.1 - 1e-41 143.5 0.0 1.5e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG91317.1 - 9.1e-08 31.7 0.0 0.002 17.4 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG91317.1 - 9.4e-08 32.0 2.1 9.4e-08 32.0 2.1 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CRG91317.1 - 2.8e-07 30.2 0.1 0.001 18.5 0.0 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG91317.1 - 6e-05 21.9 0.7 0.022 13.5 0.0 3.0 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 CRG91317.1 - 0.00056 19.1 0.1 0.0045 16.1 0.0 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein GIDA PF01134.22 CRG91317.1 - 0.0013 17.9 0.1 0.055 12.5 0.0 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 CRG91317.1 - 0.002 17.4 0.0 0.0042 16.4 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 CRG91317.1 - 0.068 13.1 0.1 7.1 6.6 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 CRG91317.1 - 0.16 11.2 0.1 15 4.7 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain Glyco_hydro_20 PF00728.22 CRG91318.1 - 6.8e-27 94.8 0.3 2.7e-18 66.5 0.0 3.1 2 1 1 3 3 3 2 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b PF02838.15 CRG91318.1 - 5.2e-08 33.7 0.0 1.1e-07 32.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 TFIIS_M PF07500.14 CRG91320.1 - 5.1e-31 107.5 2.2 5.1e-31 107.5 2.2 1.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 CRG91320.1 - 2e-18 65.9 6.4 3.2e-18 65.3 6.4 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 CRG91320.1 - 4.1e-13 49.1 2.8 4.9e-13 48.9 0.6 2.2 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Baculo_LEF5_C PF11792.8 CRG91320.1 - 0.042 13.5 0.2 0.042 13.5 0.2 2.0 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain LRR_6 PF13516.6 CRG91321.1 - 3e-12 45.5 4.6 0.0048 16.8 0.0 7.3 8 0 0 8 8 8 1 Leucine Rich repeat LRR_4 PF12799.7 CRG91321.1 - 0.00013 22.3 7.5 3.8 8.1 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) Paf1 PF03985.13 CRG91321.1 - 0.09 11.8 27.0 0.12 11.3 27.0 1.3 1 0 0 1 1 1 0 Paf1 SDA1 PF05285.12 CRG91321.1 - 0.12 11.8 34.2 0.19 11.2 34.2 1.3 1 0 0 1 1 1 0 SDA1 LKAAEAR PF15478.6 CRG91321.1 - 0.51 10.6 0.1 0.51 10.6 0.1 3.1 2 1 1 3 3 2 0 Family of unknown function with LKAAEAR motif RNA_pol_Rpc4 PF05132.14 CRG91321.1 - 1 9.8 9.5 2 8.8 9.5 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 SAPS PF04499.15 CRG91321.1 - 1.5 7.5 11.8 2 7.1 11.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AAA_23 PF13476.6 CRG91321.1 - 1.8 9.0 16.1 3.6 8.0 16.1 1.5 1 0 0 1 1 1 0 AAA domain BUD22 PF09073.10 CRG91321.1 - 1.9 7.8 26.4 2.8 7.2 26.4 1.2 1 0 0 1 1 1 0 BUD22 Merozoite_SPAM PF07133.11 CRG91321.1 - 2.1 8.3 54.3 4 7.4 54.3 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop14 PF04147.12 CRG91321.1 - 2.2 6.4 37.2 3 5.9 37.2 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4045 PF13254.6 CRG91321.1 - 2.7 7.5 12.9 3.6 7.1 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) CPSF100_C PF13299.6 CRG91321.1 - 3.3 7.9 14.4 7.3 6.7 14.4 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Drc1-Sld2 PF11719.8 CRG91321.1 - 3.3 7.1 20.0 4.9 6.6 20.0 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein DUF913 PF06025.12 CRG91321.1 - 4.1 6.3 9.6 6.9 5.5 9.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 CRG91321.1 - 4.4 6.7 25.4 7.5 5.9 25.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RR_TM4-6 PF06459.12 CRG91321.1 - 5.4 6.8 23.6 10 5.8 23.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 CRG91321.1 - 5.8 5.6 12.3 8.3 5.1 12.3 1.2 1 0 0 1 1 1 0 Presenilin DARPP-32 PF05395.12 CRG91321.1 - 8.9 6.5 23.8 19 5.5 23.8 1.6 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 Alg6_Alg8 PF03155.15 CRG91322.1 - 3.6e-132 441.8 22.7 7.7e-131 437.4 22.7 2.0 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF1746 PF08508.10 CRG91323.1 - 1.4e-40 138.2 3.7 1.9e-40 137.8 3.7 1.2 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) DUF3328 PF11807.8 CRG91325.1 - 4.9e-35 121.3 0.0 6.1e-35 121.0 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) p450 PF00067.22 CRG91326.1 - 7.4e-77 259.0 0.0 1e-76 258.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 CRG91326.1 - 6.9e-73 245.2 0.0 1.1e-72 244.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91326.1 - 1.6e-35 122.7 0.0 2.5e-35 122.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FAD_binding_1 PF00667.20 CRG91326.1 - 2.6e-23 82.8 0.0 4.4e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 CRG91326.1 - 5.4e-23 81.8 0.0 1.1e-22 80.8 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin AdenylateSensor PF16579.5 CRG91326.1 - 1.1e-17 64.6 0.1 4.9e-11 43.1 0.0 2.5 2 0 0 2 2 2 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 CRG91326.1 - 1e-15 57.5 0.1 2.2e-15 56.5 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) NAD_binding_1 PF00175.21 CRG91326.1 - 3.9e-10 40.3 0.0 1e-09 39.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain Kinase-like PF14531.6 CRG91326.1 - 2.4e-05 23.8 0.0 3.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 CRG91326.1 - 0.00065 19.3 0.2 0.0013 18.4 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 CRG91326.1 - 0.016 14.2 0.1 0.028 13.4 0.1 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Flavodoxin_5 PF12724.7 CRG91326.1 - 0.037 14.3 0.0 0.067 13.4 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain APH PF01636.23 CRG91326.1 - 0.037 14.0 0.0 0.13 12.2 0.0 1.9 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 CRG91326.1 - 0.085 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_16 PF00722.21 CRG91327.1 - 4e-39 133.9 7.1 4e-39 133.9 7.1 1.8 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 MFS_1 PF07690.16 CRG91328.1 - 4.8e-41 140.8 61.6 8.2e-40 136.8 60.0 2.9 2 1 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 CRG91328.1 - 4.5e-05 21.9 2.7 4.5e-05 21.9 2.7 2.9 2 2 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Spore_YtrH PF14034.6 CRG91328.1 - 0.0085 16.2 2.1 0.0085 16.2 2.1 3.3 3 1 2 5 5 5 1 Sporulation protein YtrH Abhydrolase_3 PF07859.13 CRG91329.1 - 2.9e-22 79.6 0.0 5.2e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 CRG91329.1 - 2.2e-17 63.0 0.0 5.7e-17 61.6 0.0 1.5 1 1 0 1 1 1 1 Steryl acetyl hydrolase FMO-like PF00743.19 CRG91330.1 - 1.9e-18 66.2 0.0 4.1e-17 61.8 0.0 2.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG91330.1 - 1.1e-12 47.8 0.1 2.1e-08 33.7 0.0 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG91330.1 - 1.9e-11 43.8 0.5 4.6e-11 42.5 0.1 1.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG91330.1 - 2e-08 34.3 0.0 2.6e-07 30.8 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CRG91330.1 - 2.3e-08 33.5 0.6 9.5e-06 25.0 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 CRG91330.1 - 4.8e-08 32.5 0.0 1.8e-06 27.4 0.0 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 CRG91330.1 - 1.9e-05 25.1 0.2 0.032 14.8 0.0 3.8 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG91330.1 - 0.00025 21.1 0.9 0.27 11.2 0.0 3.9 4 0 0 4 4 4 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG91330.1 - 0.00089 18.4 0.2 11 4.9 0.0 3.9 4 0 0 4 4 4 0 Lycopene cyclase protein DAO PF01266.24 CRG91330.1 - 0.0017 18.0 4.6 0.052 13.1 0.3 3.3 1 1 2 4 4 4 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG91330.1 - 0.0048 16.2 0.4 2.5 7.3 0.2 3.4 4 0 0 4 4 4 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 CRG91330.1 - 0.0071 15.7 1.8 7.4 5.8 1.0 3.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase Mqo PF06039.15 CRG91330.1 - 0.0091 14.6 0.1 1.2 7.6 0.0 2.4 2 1 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) NAD_binding_7 PF13241.6 CRG91330.1 - 0.0098 16.3 0.0 0.025 15.0 0.0 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 CRG91330.1 - 0.026 13.6 3.0 1.2 8.1 0.7 3.1 3 1 1 4 4 4 0 FAD binding domain Amino_oxidase PF01593.24 CRG91330.1 - 0.049 12.9 0.0 0.54 9.5 0.0 2.3 2 1 1 3 3 3 0 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 CRG91330.1 - 0.11 12.5 0.1 0.63 10.1 0.0 2.2 3 0 0 3 3 2 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.19 CRG91330.1 - 0.13 11.4 1.6 3 7.0 0.0 2.9 4 0 0 4 4 4 0 FAD binding domain GIDA PF01134.22 CRG91330.1 - 0.39 9.7 2.0 1.8 7.6 0.2 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 CRG91330.1 - 7.1 5.2 5.1 3.5 6.2 0.1 2.7 4 0 0 4 4 4 0 HI0933-like protein Fungal_trans PF04082.18 CRG91331.1 - 2e-13 50.0 0.0 4.8e-13 48.7 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain IL5 PF02025.15 CRG91331.1 - 0.16 12.3 0.0 0.63 10.4 0.0 1.9 2 0 0 2 2 2 0 Interleukin 5 TolA_bind_tri PF16331.5 CRG91331.1 - 6.3 7.0 5.6 3.3 7.8 1.9 2.3 3 0 0 3 3 3 0 TolA binding protein trimerisation NmrA PF05368.13 CRG91333.1 - 1.5e-18 67.2 0.0 2.4e-18 66.5 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG91333.1 - 4.8e-14 52.7 0.0 9.8e-14 51.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding Zn_clus PF00172.18 CRG91333.1 - 2.7e-05 24.2 8.6 6e-05 23.1 8.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sacchrp_dh_NADP PF03435.18 CRG91333.1 - 0.0038 17.5 0.2 0.084 13.1 0.0 2.8 3 0 0 3 3 3 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 CRG91333.1 - 0.045 13.8 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF29 PF01724.16 CRG91333.1 - 0.076 13.2 0.0 0.25 11.6 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF29 SnoaL_2 PF12680.7 CRG91335.1 - 1.4e-05 25.6 0.0 1.8e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain Zn_clus PF00172.18 CRG91336.1 - 0.00017 21.7 16.4 0.00035 20.6 16.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.20 CRG91338.1 - 6.7e-160 532.5 0.1 8.9e-160 532.1 0.1 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Lyase_1 PF00206.20 CRG91338.1 - 7.1e-24 84.8 0.8 1.2e-23 84.1 0.1 1.6 2 0 0 2 2 2 1 Lyase ADSL_C PF10397.9 CRG91338.1 - 4.7e-15 55.9 0.0 1.6e-14 54.2 0.0 2.0 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Cu_amine_oxidN2 PF02727.16 CRG91338.1 - 0.013 15.7 0.0 0.035 14.3 0.0 1.8 1 0 0 1 1 1 0 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 CRG91338.1 - 0.036 14.4 0.0 0.085 13.3 0.0 1.6 1 0 0 1 1 1 0 Copper amine oxidase, N3 domain Sugar_tr PF00083.24 CRG91339.1 - 1e-82 278.4 21.7 1.2e-82 278.2 21.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91339.1 - 2.3e-19 69.5 47.9 4.1e-16 58.9 19.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG91339.1 - 9.1 4.4 11.6 2.6 6.2 2.8 3.0 1 1 2 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Pyr_redox_2 PF07992.14 CRG91340.1 - 3.2e-68 230.1 9.0 4.2e-68 229.7 7.7 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 CRG91340.1 - 1.8e-39 134.4 2.8 2.5e-39 133.9 0.2 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 CRG91340.1 - 6.1e-22 78.0 11.6 5.2e-21 75.0 1.4 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG91340.1 - 3.5e-10 39.8 11.0 1.7e-09 37.6 0.3 3.2 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91340.1 - 4.3e-09 36.5 5.6 5e-05 23.5 0.6 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 CRG91340.1 - 1e-08 34.7 12.2 1.4e-07 30.9 3.8 2.9 2 2 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CRG91340.1 - 9e-08 31.7 5.3 1.5e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG91340.1 - 7.8e-07 28.5 2.7 7.8e-07 28.5 2.7 3.0 2 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.14 CRG91340.1 - 2.7e-06 26.3 13.8 0.0007 18.4 1.6 4.1 4 0 0 4 4 4 3 HI0933-like protein DAO PF01266.24 CRG91340.1 - 3.4e-06 26.9 14.6 0.036 13.6 0.5 4.1 4 0 0 4 4 4 3 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG91340.1 - 1.5e-05 24.4 7.7 0.0031 16.8 0.4 3.1 3 1 1 4 4 4 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 CRG91340.1 - 1.9e-05 24.0 0.4 0.055 12.6 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 CRG91340.1 - 9.4e-05 21.6 3.7 0.0026 16.9 0.0 2.7 3 1 0 3 3 3 1 Lycopene cyclase protein Thi4 PF01946.17 CRG91340.1 - 0.00048 19.4 6.4 0.00061 19.1 0.2 2.4 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 CRG91340.1 - 0.082 12.1 10.7 0.52 9.5 1.0 3.2 2 1 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.6 CRG91340.1 - 0.37 11.2 3.4 1.3 9.5 0.2 2.9 2 1 0 2 2 2 0 Putative NAD(P)-binding FMO-like PF00743.19 CRG91340.1 - 0.52 8.7 2.6 1.1 7.5 0.6 2.3 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like Trp_halogenase PF04820.14 CRG91340.1 - 2 7.2 7.0 1.1 8.1 0.6 2.3 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 CRG91340.1 - 4.4 7.1 7.9 0.47 10.3 1.2 2.7 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PGM_PMM_I PF02878.16 CRG91341.1 - 2.9e-34 117.7 0.0 5.1e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 CRG91341.1 - 8.3e-18 64.9 0.0 3.1e-17 63.1 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CRG91341.1 - 2.9e-13 50.0 0.0 5.1e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 CRG91341.1 - 0.00052 20.1 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain FA_desaturase PF00487.24 CRG91342.1 - 6.7e-24 85.1 29.2 1.1e-23 84.4 29.2 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 CRG91342.1 - 2.6e-11 43.5 0.0 6.2e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Unstab_antitox PF09720.10 CRG91342.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative addiction module component Methyltransf_25 PF13649.6 CRG91343.1 - 3.1e-17 63.1 0.0 6.3e-17 62.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG91343.1 - 4.2e-17 62.6 0.0 7.4e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91343.1 - 4.1e-16 59.1 0.0 5.4e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG91343.1 - 3e-15 56.4 0.0 4.6e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG91343.1 - 1.9e-12 47.8 0.0 3.2e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CRG91343.1 - 2.2e-12 46.8 0.0 3e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 CRG91343.1 - 2.4e-07 30.3 0.0 2.6e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 CRG91343.1 - 7e-06 26.1 0.0 9.9e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 CRG91343.1 - 7.7e-05 22.5 0.0 0.00011 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 CRG91343.1 - 0.00011 21.8 0.0 0.00024 20.7 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.7 CRG91343.1 - 0.00013 21.9 0.0 0.00019 21.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG91343.1 - 0.00032 20.2 0.0 0.00086 18.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase PrmA PF06325.13 CRG91343.1 - 0.00076 19.0 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 CRG91343.1 - 0.00098 18.1 0.0 0.0015 17.5 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) GCD14 PF08704.10 CRG91343.1 - 0.0013 18.4 0.0 0.51 10.0 0.0 2.1 2 0 0 2 2 2 2 tRNA methyltransferase complex GCD14 subunit ADH_zinc_N PF00107.26 CRG91343.1 - 0.002 18.1 0.0 0.0053 16.7 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase DOT1 PF08123.13 CRG91343.1 - 0.002 17.7 0.0 0.0029 17.1 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_PK PF05891.12 CRG91343.1 - 0.0025 17.4 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_15 PF09445.10 CRG91343.1 - 0.0076 15.8 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 CRG91343.1 - 0.042 13.5 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 TPMT PF05724.11 CRG91343.1 - 0.056 13.1 0.0 0.078 12.6 0.0 1.3 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) MetW PF07021.12 CRG91343.1 - 0.08 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Cpn60_TCP1 PF00118.24 CRG91344.1 - 6.5e-142 473.6 13.5 7.4e-142 473.4 13.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Phage_tube PF04985.14 CRG91344.1 - 0.023 14.4 0.0 6.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Phage tail tube protein FII CRM1_repeat PF18777.1 CRG91344.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat Pro_isomerase PF00160.21 CRG91345.1 - 2.1e-51 174.3 0.0 4.1e-51 173.4 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 CRG91345.1 - 1.9e-10 41.1 0.1 0.00054 20.7 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 CRG91345.1 - 0.0035 16.3 0.2 0.04 12.9 0.1 2.2 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 CRG91345.1 - 0.013 15.8 0.0 3.1 8.2 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TMEM154 PF15102.6 CRG91346.1 - 0.0077 16.1 0.9 0.0077 16.1 0.9 1.7 2 0 0 2 2 2 1 TMEM154 protein family DUF2207 PF09972.9 CRG91346.1 - 0.023 13.5 0.0 0.024 13.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TbpB_A PF17484.2 CRG91346.1 - 0.14 12.9 0.1 0.21 12.3 0.1 1.3 1 0 0 1 1 1 0 N-Lobe handle Tf-binding protein B LapA_dom PF06305.11 CRG91346.1 - 0.45 10.4 1.5 0.85 9.5 1.5 1.3 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF4051 PF13260.6 CRG91346.1 - 1 9.1 4.3 2.1 8.2 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) FSA_C PF10479.9 CRG91346.1 - 5.4 5.0 11.1 9.3 4.2 11.1 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Methyltransf_25 PF13649.6 CRG91347.1 - 1.6e-12 47.9 0.1 8.2e-12 45.7 0.1 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG91347.1 - 6.2e-12 46.0 0.2 2.6e-11 44.0 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91347.1 - 2.1e-07 30.9 0.0 5.5e-07 29.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG91347.1 - 9.1e-07 28.4 0.0 1.5e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG91347.1 - 1.2e-05 25.9 0.0 2.7e-05 24.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG91347.1 - 2.5e-05 24.2 0.0 4.7e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 CRG91347.1 - 0.017 15.0 0.1 0.21 11.4 0.0 2.5 2 1 1 3 3 3 0 Hypothetical methyltransferase Aldedh PF00171.22 CRG91348.1 - 7.2e-145 483.0 0.0 8.7e-145 482.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DIOX_N PF14226.6 CRG91349.1 - 8.6e-27 94.2 0.0 1.3e-26 93.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG91349.1 - 6.1e-20 71.6 0.0 9.8e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FSA_C PF10479.9 CRG91351.1 - 3 5.9 12.8 3.6 5.6 12.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Abhydrolase_6 PF12697.7 CRG91353.1 - 0.00017 22.3 0.0 0.0002 22.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Aldo_ket_red PF00248.21 CRG91354.1 - 1.5e-68 231.1 0.0 1.9e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Mig-14 PF07395.11 CRG91354.1 - 0.0045 16.4 0.0 0.0081 15.6 0.0 1.3 1 0 0 1 1 1 1 Mig-14 ADH_zinc_N PF00107.26 CRG91355.1 - 1.2e-08 35.0 0.1 2.6e-08 33.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91355.1 - 2.1e-06 27.5 0.9 1e-05 25.3 0.7 2.1 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Aldo_ket_red PF00248.21 CRG91356.1 - 4.1e-46 157.5 0.0 5.1e-44 150.6 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Dev_Cell_Death PF10539.9 CRG91356.1 - 0.013 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Development and cell death domain ADH_zinc_N PF00107.26 CRG91357.1 - 6.9e-08 32.5 0.0 1.6e-07 31.4 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91357.1 - 4.6e-06 26.5 0.0 7.6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain zf-C2H2_2 PF12756.7 CRG91358.1 - 5.1e-19 68.5 0.2 5.1e-19 68.5 0.2 1.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AA_permease PF00324.21 CRG91359.1 - 1.9e-115 386.2 38.7 2.4e-115 385.9 38.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG91359.1 - 8.1e-28 97.4 41.2 1e-27 97.0 41.2 1.1 1 0 0 1 1 1 1 Amino acid permease Fungal_trans_2 PF11951.8 CRG91360.1 - 2.8e-07 29.7 0.1 1.1e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Jacalin PF01419.17 CRG91361.1 - 6.2e-05 23.0 2.2 7.8e-05 22.6 2.2 1.2 1 0 0 1 1 1 1 Jacalin-like lectin domain DUF3328 PF11807.8 CRG91362.1 - 1.8e-37 129.3 2.9 4.8e-32 111.5 2.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF3328) DnaJ PF00226.31 CRG91363.1 - 0.0062 16.6 0.6 63 3.8 0.0 3.8 1 1 3 4 4 4 0 DnaJ domain DUF1292 PF06949.11 CRG91363.1 - 0.014 16.3 1.5 0.14 13.1 1.5 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1292) Acetyltransf_18 PF18014.1 CRG91363.1 - 0.099 12.5 0.1 0.81 9.5 0.1 2.1 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain APC_r PF05923.12 CRG91363.1 - 0.1 12.3 2.2 1.3e+02 2.4 0.0 3.9 4 0 0 4 4 4 0 APC repeat ADH_N PF08240.12 CRG91364.1 - 1.2e-08 34.8 0.0 2.3e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG91364.1 - 0.00025 21.1 0.0 0.00039 20.4 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG91364.1 - 0.12 13.4 0.0 0.21 12.6 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Sugar_tr PF00083.24 CRG91365.1 - 2e-119 399.4 24.9 2.3e-119 399.2 24.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91365.1 - 1.8e-25 89.7 31.7 7.9e-19 67.8 7.7 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily F-box-like PF12937.7 CRG91366.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 F-box-like AAA PF00004.29 CRG91367.1 - 3e-08 34.2 3.1 1.4e-06 28.8 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG91367.1 - 1.9e-05 25.1 5.1 0.0018 18.7 0.0 4.2 3 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 CRG91367.1 - 0.00032 21.0 6.2 0.24 11.7 0.0 4.5 4 1 0 4 4 4 1 AAA domain Torsin PF06309.11 CRG91367.1 - 0.0032 17.6 0.0 0.0081 16.3 0.0 1.6 1 0 0 1 1 1 1 Torsin NACHT PF05729.12 CRG91367.1 - 0.012 15.6 0.6 8.8 6.2 0.1 3.2 3 0 0 3 3 3 0 NACHT domain AAA_25 PF13481.6 CRG91367.1 - 0.02 14.4 0.3 2.8 7.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_5 PF07728.14 CRG91367.1 - 0.077 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 CRG91367.1 - 0.089 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain FAD_binding_3 PF01494.19 CRG91368.1 - 4.9e-42 144.4 0.0 9.2e-42 143.5 0.0 1.4 1 1 1 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 CRG91368.1 - 9.9e-05 22.5 0.1 0.00029 21.0 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG91368.1 - 0.00018 20.8 0.1 0.00051 19.4 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91368.1 - 0.00032 19.5 0.0 0.00053 18.8 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CRG91368.1 - 0.0006 20.3 0.1 0.043 14.4 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG91368.1 - 0.005 16.1 0.0 0.013 14.8 0.1 1.6 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 CRG91368.1 - 0.0078 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A DAO PF01266.24 CRG91368.1 - 0.011 15.3 1.7 0.23 11.0 0.3 2.6 1 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG91368.1 - 0.015 14.4 0.1 0.086 11.9 0.2 1.9 1 1 1 2 2 2 0 FAD binding domain Lycopene_cycl PF05834.12 CRG91368.1 - 0.02 13.9 0.0 0.035 13.1 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 CRG91368.1 - 0.049 13.0 0.1 0.07 12.5 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG91368.1 - 0.083 12.9 0.5 2.2 8.2 0.0 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG91368.1 - 0.086 12.1 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Methyltransf_2 PF00891.18 CRG91369.1 - 1.9e-23 82.9 0.0 3.2e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation PF08100.11 CRG91369.1 - 0.00074 19.5 0.0 0.003 17.5 0.0 2.2 2 0 0 2 2 2 1 Dimerisation domain Methyltransf_23 PF13489.6 CRG91369.1 - 0.02 14.7 0.0 0.075 12.9 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain Zn_clus PF00172.18 CRG91370.1 - 0.0018 18.4 1.0 0.0018 18.4 1.0 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_8 PF13450.6 CRG91371.1 - 1.3e-13 50.9 0.0 2.7e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 CRG91371.1 - 1.9e-09 37.4 0.0 2.8e-05 23.6 0.0 3.0 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 CRG91371.1 - 0.0051 16.8 0.1 3.4 7.6 0.0 2.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 CRG91371.1 - 0.0075 15.5 0.0 0.087 12.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG91371.1 - 0.013 15.1 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG91371.1 - 0.017 14.3 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 CRG91371.1 - 0.027 13.3 0.0 0.044 12.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 CRG91371.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 CRG91371.1 - 0.16 12.5 0.0 0.92 10.1 0.0 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG91371.1 - 0.19 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Usp PF00582.26 CRG91373.1 - 1.2e-22 81.0 0.8 2.6e-22 79.8 0.0 1.9 2 0 0 2 2 2 1 Universal stress protein family MIF4G PF02854.19 CRG91374.1 - 3.6e-54 183.6 0.0 5.7e-54 183.0 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 CRG91374.1 - 3.6e-23 81.5 1.2 1.4e-22 79.6 1.2 2.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 TB2_DP1_HVA22 PF03134.19 CRG91375.1 - 2e-23 82.1 4.1 3.5e-23 81.3 4.1 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DHC_N1 PF08385.12 CRG91375.1 - 0.12 10.9 0.0 0.16 10.6 0.0 1.2 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 PNP_UDP_1 PF01048.20 CRG91380.1 - 8.7e-13 48.1 0.2 1.9e-12 47.0 0.2 1.6 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG91380.1 - 2.8e-07 30.6 0.0 5.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG91380.1 - 5.5e-05 23.6 0.1 0.00017 22.0 0.1 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 CRG91380.1 - 0.02 14.9 0.0 0.68 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CRG91380.1 - 0.026 13.7 0.0 0.043 13.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 CRG91380.1 - 0.032 14.5 0.1 0.34 11.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CRG91380.1 - 0.09 13.1 0.1 0.24 11.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CRG91380.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter TANGO2 PF05742.12 CRG91381.1 - 2.5e-62 211.2 0.0 3.1e-62 210.9 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 BPL_N PF09825.9 CRG91382.1 - 1.1e-152 508.5 0.0 1.4e-152 508.2 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 CRG91382.1 - 1.7e-25 89.4 0.1 2.8e-25 88.7 0.1 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 CRG91382.1 - 0.00017 21.4 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain CHCH PF06747.13 CRG91383.1 - 2.7e-05 24.2 8.3 4e-05 23.6 8.3 1.3 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 CRG91383.1 - 0.0087 16.0 1.6 0.27 11.3 0.2 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 CRG91383.1 - 0.077 13.0 5.1 0.47 10.5 5.1 2.0 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Mgm101p PF06420.12 CRG91384.1 - 2.5e-86 287.5 0.0 3.3e-86 287.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Sporozoite_P67 PF05642.11 CRG91384.1 - 0.79 7.7 11.9 1 7.3 11.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MGC-24 PF05283.11 CRG91384.1 - 6.7 7.2 9.0 12 6.3 9.0 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin MS_channel PF00924.18 CRG91385.1 - 1.2e-18 67.5 2.4 2e-18 66.7 2.4 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel LRR19-TM PF15176.6 CRG91385.1 - 0.013 15.4 0.1 0.04 13.9 0.1 1.8 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain EF-hand_1 PF00036.32 CRG91385.1 - 0.066 12.8 0.2 0.14 11.7 0.2 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 CRG91385.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 CRG91385.1 - 0.16 11.5 0.0 0.41 10.2 0.0 1.7 1 0 0 1 1 1 0 EF hand PhyH PF05721.13 CRG91386.1 - 2.3e-22 80.3 0.2 3.2e-22 79.9 0.2 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) zf-RING_2 PF13639.6 CRG91388.1 - 8.3e-13 48.4 8.1 9.9e-13 48.2 6.0 2.1 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 CRG91388.1 - 1.4e-10 40.8 2.5 2.8e-10 39.8 2.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 CRG91388.1 - 2.1e-09 37.0 6.1 4.9e-09 35.9 6.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG91388.1 - 3.4e-08 33.2 4.0 6e-08 32.4 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 CRG91388.1 - 1.3e-06 28.5 8.1 9.6e-06 25.8 8.2 2.4 1 1 1 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 CRG91388.1 - 1.7e-05 24.6 5.0 0.00011 22.0 5.2 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 CRG91388.1 - 3.3e-05 23.8 2.3 6.9e-05 22.7 2.3 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 CRG91388.1 - 0.00016 21.4 2.2 0.00032 20.5 2.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CRG91388.1 - 0.00039 20.4 2.0 0.0013 18.7 1.5 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 CRG91388.1 - 0.0014 18.6 6.3 0.0035 17.3 6.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 CRG91388.1 - 0.003 17.3 4.2 0.0069 16.2 4.2 1.6 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 CRG91388.1 - 0.023 15.0 1.8 0.047 14.0 1.8 1.6 1 0 0 1 1 1 0 RING-like domain Zn_ribbon_17 PF17120.5 CRG91388.1 - 0.12 12.0 1.9 0.26 10.9 1.9 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Rad50_zn_hook PF04423.14 CRG91388.1 - 0.13 12.1 0.1 4.5 7.2 0.1 2.4 2 0 0 2 2 2 0 Rad50 zinc hook motif Prok-RING_1 PF14446.6 CRG91388.1 - 0.61 10.1 4.6 0.79 9.7 1.9 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C3HC4_4 PF15227.6 CRG91388.1 - 0.92 9.7 5.7 1.9 8.7 5.7 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3H2C3 PF17122.5 CRG91388.1 - 5.8 7.0 6.7 2.7 8.1 2.1 2.6 2 0 0 2 2 2 0 Zinc-finger Aminotran_1_2 PF00155.21 CRG91389.1 - 1.1e-85 288.0 0.0 1.5e-85 287.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Syntaxin-18_N PF10496.9 CRG91390.1 - 5.9e-14 52.1 0.3 5.9e-14 52.1 0.3 3.1 4 2 0 4 4 4 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 CRG91390.1 - 0.00048 20.1 0.3 0.0047 16.9 0.0 2.5 2 0 0 2 2 2 1 SNARE domain DUF16 PF01519.16 CRG91390.1 - 2 9.0 13.1 3.6 8.1 1.2 3.4 3 0 0 3 3 3 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 CRG91390.1 - 2.7 8.3 10.9 1.1 9.6 1.5 3.0 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_1 PF00515.28 CRG91391.1 - 4.4e-14 51.6 3.5 3.6e-06 26.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 CRG91391.1 - 1.1e-12 47.1 2.5 0.0002 21.2 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat HMA PF00403.26 CRG91391.1 - 1.9e-12 47.5 0.0 3.7e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain TPR_12 PF13424.6 CRG91391.1 - 6e-09 36.1 0.1 1.7e-05 25.0 0.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG91391.1 - 4.5e-08 32.7 0.2 0.00052 20.0 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat Sod_Cu PF00080.20 CRG91391.1 - 2.4e-07 31.0 0.0 4.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) TPR_11 PF13414.6 CRG91391.1 - 2.1e-06 27.3 0.8 3.5e-05 23.4 0.1 3.1 2 1 1 3 3 3 1 TPR repeat TPR_7 PF13176.6 CRG91391.1 - 5.3e-06 26.1 0.3 0.00046 20.0 0.1 3.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 CRG91391.1 - 5.8e-06 26.6 0.1 4.8 8.0 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat PB1 PF00564.24 CRG91391.1 - 0.00055 19.8 0.1 0.00099 19.0 0.1 1.5 1 0 0 1 1 1 1 PB1 domain TPR_9 PF13371.6 CRG91391.1 - 0.0038 17.4 0.0 1.4 9.2 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 CRG91391.1 - 0.0039 17.8 0.0 0.58 10.9 0.0 2.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 CRG91391.1 - 0.016 15.0 0.4 5.2 7.1 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG91391.1 - 0.024 15.4 0.0 2 9.5 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 CRG91391.1 - 0.048 14.3 0.5 55 4.8 0.0 4.3 4 1 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG91391.1 - 0.069 13.4 0.3 1.6 9.0 0.1 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Pkinase PF00069.25 CRG91392.1 - 1.1e-63 215.1 0.0 1.9e-63 214.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91392.1 - 3.1e-26 92.2 0.0 6.4e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 CRG91392.1 - 0.0022 17.6 0.1 0.0022 17.6 0.1 1.8 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 CRG91392.1 - 0.021 14.2 0.1 0.04 13.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 CRG91392.1 - 0.027 13.4 0.0 0.027 13.4 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 CRG91392.1 - 0.1 12.5 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Spt20 PF12090.8 CRG91392.1 - 3.9 7.0 9.9 7.8 6.0 9.9 1.4 1 0 0 1 1 1 0 Spt20 family U79_P34 PF03064.16 CRG91392.1 - 8.3 5.7 12.4 14 4.9 12.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MCM_bind PF09739.9 CRG91392.1 - 9 4.6 7.9 14 4.0 7.9 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Methyltransf_28 PF02636.17 CRG91394.1 - 5.5e-79 265.5 0.0 7.2e-79 265.1 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase TUDOR PF00567.24 CRG91394.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Tudor domain Pkinase PF00069.25 CRG91395.1 - 5.5e-23 81.7 0.0 5.8e-22 78.3 0.0 2.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91395.1 - 2e-11 43.7 0.0 5.2e-11 42.3 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 CRG91395.1 - 0.079 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SH3BGR PF04908.15 CRG91396.1 - 0.076 13.2 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein CPCFC PF17223.3 CRG91396.1 - 1.3 8.9 4.3 1.2 8.9 0.5 2.4 2 0 0 2 2 2 0 Cuticle protein CPCFC CorA PF01544.18 CRG91396.1 - 4 6.7 7.8 33 3.7 7.8 2.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein AA_permease_2 PF13520.6 CRG91397.1 - 1e-40 139.9 26.5 2.1e-33 115.8 16.3 2.1 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 CRG91397.1 - 3.9e-08 32.3 16.2 3.9e-08 32.3 16.2 2.2 1 1 1 2 2 2 2 Amino acid permease Aa_trans PF01490.18 CRG91397.1 - 2.3e-05 23.3 15.8 2.3e-05 23.3 15.8 1.6 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Epimerase PF01370.21 CRG91398.1 - 4.9e-12 45.8 0.2 2.2e-11 43.7 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG91398.1 - 2.6e-11 43.1 0.1 3.9e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG91398.1 - 5.2e-09 36.3 0.2 9.7e-09 35.4 0.2 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 CRG91398.1 - 2.4e-08 33.8 0.1 3.6e-08 33.2 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 CRG91398.1 - 4.7e-07 29.6 0.4 1.3e-06 28.2 0.3 1.7 2 0 0 2 2 2 1 NmrA-like family NAD_binding_4 PF07993.12 CRG91398.1 - 3.8e-06 26.3 0.3 0.0016 17.6 0.1 2.1 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CRG91398.1 - 0.00048 19.4 0.0 0.00085 18.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Rhodanese PF00581.20 CRG91400.1 - 4.8e-11 43.1 0.0 6.2e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Ribosomal_S21 PF01165.20 CRG91401.1 - 1.7e-08 34.1 0.9 3.5e-08 33.0 0.9 1.6 1 0 0 1 1 1 1 Ribosomal protein S21 PGI PF00342.19 CRG91403.1 - 1.3e-240 799.1 1.4 1.5e-240 798.9 1.4 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase PWI PF01480.17 CRG91404.1 - 4.8e-16 58.8 0.9 1.3e-15 57.4 0.9 1.8 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 CRG91404.1 - 0.14 12.0 0.0 0.76 9.6 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MR_MLE_C PF13378.6 CRG91405.1 - 2.6e-58 197.2 0.0 4.5e-58 196.4 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CRG91405.1 - 0.00015 21.9 0.0 0.00032 20.9 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 CRG91405.1 - 0.13 11.4 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Cupin_2 PF07883.11 CRG91406.1 - 9.8e-10 38.0 0.3 1.1e-06 28.2 0.3 2.3 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 CRG91406.1 - 1.5e-08 34.4 0.0 2.1e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 CRG91406.1 - 0.019 14.7 0.1 0.91 9.3 0.1 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF861) TauD PF02668.16 CRG91408.1 - 2.2e-46 158.8 0.1 2.9e-46 158.4 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DAG1 PF05454.11 CRG91408.1 - 0.17 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) Fungal_trans PF04082.18 CRG91409.1 - 2.2e-07 30.2 0.0 4.2e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain UDPG_MGDP_dh_N PF03721.14 CRG91409.1 - 0.026 14.1 0.0 0.044 13.3 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short PF00106.25 CRG91410.1 - 2.6e-17 62.9 0.0 2.8e-16 59.6 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG91410.1 - 4.1e-08 33.3 0.0 7e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG91410.1 - 1.7e-07 31.0 0.0 5.3e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Glyco_hydro_92 PF07971.12 CRG91412.1 - 2.3e-149 498.3 3.6 3.1e-149 497.8 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 CRG91412.1 - 1.3e-56 192.2 2.9 2.7e-56 191.1 2.9 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain CMD PF02627.20 CRG91413.1 - 0.014 15.4 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family TIM21 PF08294.11 CRG91414.1 - 4.5e-39 133.6 0.0 5.5e-39 133.3 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 CRG91414.1 - 1.8e-07 30.9 0.0 8.1e-07 28.8 0.0 2.0 2 1 0 2 2 2 1 Cytochrome oxidase complex assembly protein 1 FF PF01846.19 CRG91414.1 - 0.2 11.9 0.1 1.7 8.9 0.0 2.1 2 0 0 2 2 2 0 FF domain ArfGap PF01412.18 CRG91415.1 - 9.6e-35 119.2 0.1 1.6e-34 118.5 0.1 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Pterin_bind PF00809.22 CRG91416.1 - 2.1e-77 260.1 0.0 2.8e-77 259.7 0.0 1.1 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 CRG91416.1 - 3.2e-35 121.0 0.0 5.7e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) NMO PF03060.15 CRG91417.1 - 7.5e-60 203.0 0.7 1.1e-59 202.5 0.7 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 CRG91417.1 - 4.7e-13 48.8 0.5 8.8e-13 48.0 0.5 1.4 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 CRG91417.1 - 1.8e-07 30.5 1.1 2.9e-07 29.8 1.1 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 CRG91417.1 - 3.3e-06 26.5 0.2 5.4e-06 25.8 0.2 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase DHO_dh PF01180.21 CRG91417.1 - 0.0016 17.7 0.1 0.0025 17.1 0.1 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase Radial_spoke_3 PF06098.11 CRG91417.1 - 0.15 11.3 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 Transp_cyt_pur PF02133.15 CRG91418.1 - 4.3e-43 147.7 40.1 5.3e-43 147.4 40.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF1129 PF06570.11 CRG91418.1 - 2.2 7.7 12.5 2.7 7.5 0.5 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) eIF3g PF12353.8 CRG91419.1 - 8.9e-45 152.1 2.8 1.3e-44 151.6 2.8 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 CRG91419.1 - 8.2e-17 60.8 0.0 1.3e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 CRG91419.1 - 0.022 15.1 0.3 0.052 13.9 0.3 1.6 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 PHM7_cyt PF14703.6 CRG91419.1 - 0.099 12.9 0.2 1.9 8.7 0.1 2.3 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 CRG91419.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif ribosomal_L24 PF17136.4 CRG91419.1 - 6.5 7.2 9.9 0.2 12.1 1.2 2.6 2 2 0 2 2 2 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 NDT80_PhoG PF05224.12 CRG91420.1 - 8.8e-42 143.4 0.4 1.5e-41 142.7 0.4 1.4 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Glyco_transf_8 PF01501.20 CRG91421.1 - 3.7e-11 43.1 0.4 2.9e-09 36.9 0.4 2.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 CRG91421.1 - 0.0042 16.5 0.0 0.014 14.8 0.0 1.8 1 1 0 1 1 1 1 Mannosyltransferase putative p450 PF00067.22 CRG91422.1 - 1.1e-60 205.7 0.0 1.5e-60 205.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AMP-binding PF00501.28 CRG91424.1 - 1.1e-87 294.4 0.0 1.6e-87 293.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG91424.1 - 0.0002 22.2 0.9 0.00067 20.6 0.9 2.0 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Methyltransf_16 PF10294.9 CRG91425.1 - 1.4e-10 41.2 0.0 3.3e-05 23.7 0.0 2.8 2 1 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 CRG91425.1 - 0.044 13.6 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1682 PF07946.14 CRG91426.1 - 4.2 6.5 5.8 7.4 5.7 5.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CCDC-167 PF15188.6 CRG91426.1 - 4.5 7.7 6.5 8.2 6.8 6.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 GMC_oxred_N PF00732.19 CRG91428.1 - 4.8e-65 219.8 0.0 6.1e-65 219.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG91428.1 - 1.9e-31 109.5 0.0 3.5e-31 108.7 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CRG91428.1 - 2.1e-08 33.7 0.0 0.00067 18.8 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 CRG91428.1 - 4.8e-06 25.9 0.0 0.00012 21.2 0.1 2.1 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG91428.1 - 2.6e-05 23.6 0.1 0.0011 18.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG91428.1 - 4e-05 23.0 0.5 0.092 12.0 0.4 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91428.1 - 0.00026 19.8 0.7 0.0018 17.0 0.2 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 CRG91428.1 - 0.00032 20.9 0.4 0.00093 19.4 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG91428.1 - 0.00039 20.1 0.3 0.0033 17.1 0.2 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG91428.1 - 0.00053 19.3 0.3 0.0016 17.7 0.1 1.8 2 0 0 2 2 2 1 Thi4 family TrkA_N PF02254.18 CRG91428.1 - 0.011 16.0 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_3 PF01494.19 CRG91428.1 - 0.029 13.6 0.1 0.066 12.4 0.1 1.6 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 CRG91428.1 - 0.059 12.2 0.8 0.09 11.6 0.8 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 CRG91428.1 - 0.083 13.5 0.2 0.35 11.5 0.2 2.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG91428.1 - 0.14 12.1 0.6 0.27 11.2 0.1 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding HSP70 PF00012.20 CRG91429.1 - 3.8e-266 884.1 16.6 4.3e-266 883.9 16.6 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CRG91429.1 - 9e-15 54.3 7.1 9.7e-13 47.6 1.5 3.1 3 0 0 3 3 3 2 MreB/Mbl protein FGGY_C PF02782.16 CRG91429.1 - 0.00079 19.2 0.0 0.0021 17.8 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 CRG91429.1 - 0.017 14.4 0.8 0.58 9.3 0.1 2.5 1 1 1 2 2 2 0 StbA protein Big_3_4 PF13754.6 CRG91429.1 - 0.082 12.6 0.0 3.8 7.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function Toxin-deaminase PF14424.6 CRG91429.1 - 0.093 12.8 1.0 0.22 11.6 0.0 2.1 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases TetR_C_25 PF17933.1 CRG91429.1 - 0.13 12.6 0.1 27 5.2 0.0 2.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4363 PF14276.6 CRG91429.1 - 0.95 9.6 3.9 2 8.6 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) zf-C4H2 PF10146.9 CRG91429.1 - 4.8 7.4 6.8 12 6.1 6.8 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein FtsA PF14450.6 CRG91429.1 - 8.3 6.9 13.0 4.1 7.9 0.6 4.1 3 3 0 3 3 3 0 Cell division protein FtsA DUF2415 PF10313.9 CRG91430.1 - 5.6e-14 51.8 0.1 1.5e-13 50.4 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) DSHCT PF08148.12 CRG91431.1 - 1.6e-52 177.5 0.4 3.5e-52 176.4 0.4 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 CRG91431.1 - 8.5e-41 138.9 0.1 1.8e-40 137.9 0.1 1.6 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 CRG91431.1 - 3.1e-22 79.8 0.0 6e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 CRG91431.1 - 2.7e-18 66.3 0.0 5.5e-18 65.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 CRG91431.1 - 4.8e-06 26.7 0.0 1.1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG91431.1 - 8.6e-06 26.1 0.0 2.5e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain IBN_N PF03810.19 CRG91432.1 - 6.5e-11 42.0 7.6 0.00023 21.0 0.0 5.2 5 0 0 5 5 5 2 Importin-beta N-terminal domain Cse1 PF08506.10 CRG91432.1 - 2.1e-06 26.9 0.0 6.1e-06 25.3 0.0 1.9 1 0 0 1 1 1 1 Cse1 RTP1_C1 PF10363.9 CRG91432.1 - 0.036 14.2 0.2 0.61 10.3 0.1 2.9 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 SapB_2 PF03489.17 CRG91432.1 - 0.082 13.0 1.5 1.6 8.9 0.0 3.8 3 0 0 3 3 3 0 Saposin-like type B, region 2 HEAT_2 PF13646.6 CRG91432.1 - 0.087 13.2 1.9 1.8 9.0 0.0 3.4 3 0 0 3 3 3 0 HEAT repeats Xpo1 PF08389.12 CRG91432.1 - 0.11 12.6 3.9 1.3 9.1 0.0 4.0 4 0 0 4 4 4 0 Exportin 1-like protein DCB PF16213.5 CRG91432.1 - 0.16 11.6 0.2 0.5 10.0 0.2 1.8 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 HEAT_EZ PF13513.6 CRG91432.1 - 0.45 11.1 8.6 26 5.5 0.6 5.1 5 1 0 5 5 5 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 CRG91432.1 - 1.1 9.9 5.6 3.6 8.3 0.1 4.4 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region RRM_1 PF00076.22 CRG91434.1 - 5.2e-08 32.6 0.0 1.1e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG91434.1 - 4.6e-06 26.5 0.0 7.8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif CCD48 PF15799.5 CRG91434.1 - 0.00064 18.2 0.6 0.0014 17.1 0.6 1.5 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 DUF2046 PF09755.9 CRG91434.1 - 0.016 14.4 0.1 0.23 10.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) DegS PF05384.11 CRG91434.1 - 0.027 14.0 0.4 0.027 14.0 0.4 2.0 2 0 0 2 2 2 0 Sensor protein DegS GreA_GreB_N PF03449.15 CRG91434.1 - 0.084 13.0 1.3 0.31 11.2 0.5 2.3 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal DUF4763 PF15960.5 CRG91434.1 - 0.1 11.9 0.5 0.43 9.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) FlaC_arch PF05377.11 CRG91434.1 - 0.12 12.8 1.7 0.2 12.1 0.2 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TMCO5 PF14992.6 CRG91434.1 - 0.2 11.2 1.3 0.48 9.9 0.1 2.0 2 0 0 2 2 2 0 TMCO5 family SlyX PF04102.12 CRG91434.1 - 0.2 12.3 4.9 14 6.3 0.1 3.0 3 0 0 3 3 3 0 SlyX Peptidase_S28 PF05577.12 CRG91435.1 - 2.5e-51 174.8 1.5 9e-41 140.1 0.1 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase S28 DUF1465 PF07323.12 CRG91435.1 - 0.02 14.7 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) Ank_2 PF12796.7 CRG91437.1 - 6.5e-64 212.5 0.0 3.5e-14 53.1 0.0 5.7 1 1 6 7 7 7 7 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG91437.1 - 1.6e-36 124.2 3.4 8.6e-08 32.6 0.0 9.3 2 2 8 10 10 10 10 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG91437.1 - 4.2e-33 109.7 2.5 0.0003 21.0 0.0 10.8 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 CRG91437.1 - 4.5e-31 106.5 3.7 1.6e-07 31.4 0.0 8.1 3 3 5 8 8 8 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG91437.1 - 5.2e-24 83.6 0.0 0.0052 17.2 0.0 8.5 8 1 0 8 8 8 6 Ankyrin repeat DUF3447 PF11929.8 CRG91437.1 - 0.039 13.9 0.0 0.71 9.9 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) Rotamase PF00639.21 CRG91438.1 - 5.2 8.1 11.1 4.1 8.4 1.1 2.8 2 0 0 2 2 2 0 PPIC-type PPIASE domain DbpA PF03880.15 CRG91439.1 - 0.12 12.4 0.3 0.29 11.2 0.0 1.8 2 0 0 2 2 2 0 DbpA RNA binding domain MFS_1 PF07690.16 CRG91440.1 - 7.1e-32 110.7 36.7 5.9e-29 101.1 8.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91440.1 - 3.1e-11 42.8 2.0 3.1e-11 42.8 2.0 1.9 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_3 PF05977.13 CRG91440.1 - 0.01 14.3 4.7 0.12 10.7 2.5 2.3 1 1 1 2 2 2 0 Transmembrane secretion effector MFS_1_like PF12832.7 CRG91440.1 - 0.01 14.7 14.2 0.043 12.7 3.8 2.7 3 0 0 3 3 3 0 MFS_1 like family Aldose_epim PF01263.20 CRG91441.1 - 8.5e-49 166.5 0.3 1.2e-48 166.0 0.3 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase Arm-DNA-bind_2 PF12167.8 CRG91441.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Arm DNA-binding domain Ferric_reduct PF01794.19 CRG91442.1 - 5.7e-27 94.3 5.6 1.2e-26 93.3 5.6 1.6 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG91442.1 - 3.4e-20 72.7 0.1 5.5e-20 72.1 0.1 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG91442.1 - 3.6e-14 52.8 0.0 1.2e-13 51.1 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 CRG91442.1 - 0.00013 22.6 0.0 0.13 13.0 0.0 2.6 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain ATP-synt_ab_C PF00306.27 CRG91442.1 - 0.081 13.3 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 ATP synthase alpha/beta chain, C terminal domain FAD_binding_4 PF01565.23 CRG91443.1 - 6.8e-21 74.5 0.7 1.3e-20 73.6 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 CRG91443.1 - 4.8e-10 39.4 0.1 4.8e-10 39.4 0.1 1.9 2 0 0 2 2 2 1 Berberine and berberine like DUF3331 PF11811.8 CRG91443.1 - 1.1 9.1 3.4 11 6.0 0.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3331) Fungal_trans PF04082.18 CRG91445.1 - 4.1e-30 104.7 2.0 7e-30 103.9 2.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91445.1 - 0.001 19.1 17.4 0.0017 18.4 17.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl-ACP_TE PF01643.17 CRG91445.1 - 0.15 11.3 0.0 0.37 10.1 0.0 1.6 1 0 0 1 1 1 0 Acyl-ACP thioesterase Col_cuticle_N PF01484.17 CRG91447.1 - 0.08 13.0 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Vg_Tdu PF07545.14 CRG91447.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Vestigial/Tondu family AMP-binding PF00501.28 CRG91448.1 - 1.1e-89 300.9 0.0 1.5e-89 300.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG91448.1 - 6.5e-11 43.1 0.1 1.3e-10 42.1 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Sugar_tr PF00083.24 CRG91449.1 - 2.6e-59 201.3 12.0 2.6e-59 201.3 12.0 1.5 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91449.1 - 2.4e-17 62.9 71.8 7.6e-16 58.0 37.2 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG91449.1 - 4.2e-05 22.3 1.8 4.2e-05 22.3 1.8 3.3 2 1 1 3 3 3 3 MFS/sugar transport protein MFS_1_like PF12832.7 CRG91449.1 - 1 8.1 22.3 0.023 13.5 5.1 3.9 3 1 0 4 4 4 0 MFS_1 like family MFS_1 PF07690.16 CRG91450.1 - 6.2e-19 68.1 25.1 8.8e-19 67.6 25.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 CRG91450.1 - 4.9e-10 39.3 4.8 4.9e-10 39.3 4.8 2.5 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Amidohydro_1 PF01979.20 CRG91451.1 - 1.8e-19 70.3 0.0 2.5e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG91451.1 - 1.4e-12 47.8 0.3 8.8e-09 35.3 0.1 2.3 2 0 0 2 2 2 2 Amidohydrolase family GMC_oxred_N PF00732.19 CRG91452.1 - 1e-49 169.6 0.0 1.3e-49 169.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG91452.1 - 4.8e-37 127.7 0.0 7.1e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CRG91452.1 - 4.8e-05 22.6 0.0 6.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 CRG91452.1 - 5e-05 23.5 0.1 0.00018 21.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG91452.1 - 0.00056 19.1 0.0 0.13 11.3 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 CRG91452.1 - 0.001 18.7 0.1 0.0036 16.9 0.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG91452.1 - 0.0015 17.8 0.0 0.0048 16.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG91452.1 - 0.012 14.5 0.0 0.017 14.0 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 CRG91452.1 - 0.012 16.1 0.1 0.83 10.3 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG91452.1 - 0.13 11.5 0.0 0.29 10.3 0.0 1.5 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 CRG91452.1 - 0.2 10.9 0.1 4.2 6.6 0.0 2.3 2 1 0 2 2 2 0 FAD dependent oxidoreductase Aldedh PF00171.22 CRG91453.1 - 2.9e-156 520.6 0.2 3.5e-156 520.3 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Wtap PF17098.5 CRG91453.1 - 0.061 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 WTAP/Mum2p family Glucosamine_iso PF01182.20 CRG91454.1 - 5.5e-22 78.8 0.0 7.8e-22 78.3 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Glyco_hydro_3 PF00933.21 CRG91455.1 - 2.1e-69 234.3 0.1 2.7e-69 234.0 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 CRG91455.1 - 1.7e-05 24.9 0.0 3.3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Acetyltransf_1 PF00583.25 CRG91455.1 - 4.2e-05 23.8 0.0 0.00014 22.1 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family NDT80_PhoG PF05224.12 CRG91456.1 - 2.4e-38 132.2 0.0 5e-38 131.2 0.0 1.6 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Ferric_reduct PF01794.19 CRG91456.1 - 2.2e-20 73.1 12.5 4.3e-20 72.1 12.5 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 CRG91456.1 - 9.3e-14 51.8 0.1 1.8e-13 50.9 0.1 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG91456.1 - 1.1e-10 41.5 0.0 3.7e-10 39.9 0.0 1.8 2 0 0 2 2 2 1 FAD-binding domain DUF4405 PF14358.6 CRG91456.1 - 0.0015 19.0 7.7 0.24 11.9 1.6 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4405) NAD_binding_1 PF00175.21 CRG91456.1 - 0.085 13.5 0.3 2.6 8.7 0.3 2.5 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain Ribosomal_60s PF00428.19 CRG91456.1 - 8.5 7.0 21.2 0.36 11.5 2.5 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DAP3 PF10236.9 CRG91457.1 - 1.8e-96 323.0 0.0 2.3e-96 322.7 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 CRG91457.1 - 0.002 18.6 0.0 0.006 17.0 0.0 1.7 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 CRG91457.1 - 0.0046 17.0 0.0 0.0084 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain RRS1 PF04939.12 CRG91458.1 - 1.8e-59 200.2 2.7 2.2e-59 199.9 2.7 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) MTP18 PF10558.9 CRG91459.1 - 1.9e-80 268.8 0.1 1.9e-80 268.8 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial 18 KDa protein (MTP18) ATP19 PF11022.8 CRG91460.1 - 8.5e-28 96.5 0.0 9.5e-28 96.4 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K ACPS PF01648.20 CRG91461.1 - 5.5e-13 49.0 0.0 6.8e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 CRG91461.1 - 0.087 13.0 2.7 0.7 10.1 2.7 2.1 1 1 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain PHP PF02811.19 CRG91462.1 - 3.4e-17 63.2 0.0 5.9e-17 62.5 0.0 1.4 1 1 0 1 1 1 1 PHP domain CENP-M PF11111.8 CRG91462.1 - 0.066 12.4 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Centromere protein M (CENP-M) FKBP_C PF00254.28 CRG91463.1 - 3.7e-14 52.8 0.0 4.2e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase LysM PF01476.20 CRG91464.1 - 0.0024 17.9 0.0 0.011 15.8 0.0 2.2 2 0 0 2 2 2 1 LysM domain AAA PF00004.29 CRG91465.1 - 2.4e-37 128.3 0.0 6.7e-37 126.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG91465.1 - 7e-09 35.4 0.0 1.5e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 CRG91465.1 - 5.2e-05 23.0 0.0 0.00011 22.0 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CRG91465.1 - 6.6e-05 22.9 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG91465.1 - 7.1e-05 23.2 1.3 0.00052 20.4 0.1 2.8 2 2 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 CRG91465.1 - 8.7e-05 22.5 0.1 0.00078 19.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CRG91465.1 - 0.00021 21.6 0.1 0.01 16.1 0.0 3.1 2 2 1 3 3 3 1 AAA domain AAA_2 PF07724.14 CRG91465.1 - 0.00046 20.4 0.0 0.00091 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 CRG91465.1 - 0.00075 19.7 0.0 0.0021 18.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 CRG91465.1 - 0.00096 19.7 0.0 0.0037 17.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CRG91465.1 - 0.0014 18.4 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 CRG91465.1 - 0.0015 17.9 0.1 0.0032 16.9 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 CRG91465.1 - 0.0021 18.3 0.1 0.036 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CRG91465.1 - 0.0024 18.2 0.0 0.0074 16.7 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 CRG91465.1 - 0.0047 16.5 0.1 0.055 13.0 0.1 2.4 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 CRG91465.1 - 0.0048 16.3 0.0 2.6 7.4 0.0 2.5 2 0 0 2 2 2 1 Bacterial TniB protein NACHT PF05729.12 CRG91465.1 - 0.0064 16.4 0.1 0.026 14.5 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 CRG91465.1 - 0.011 15.5 0.0 0.025 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 CRG91465.1 - 0.024 13.7 0.0 0.039 13.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Rad17 PF03215.15 CRG91465.1 - 0.026 14.4 0.1 0.057 13.3 0.1 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain Sigma54_activ_2 PF14532.6 CRG91465.1 - 0.028 14.5 0.0 0.072 13.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 CRG91465.1 - 0.03 14.0 0.0 0.09 12.5 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 CRG91465.1 - 0.051 14.1 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 CRG91465.1 - 0.094 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 CRG91465.1 - 0.11 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.17 CRG91465.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CPT PF07931.12 CRG91465.1 - 0.13 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ATPase_2 PF01637.18 CRG91465.1 - 0.14 12.0 0.0 0.39 10.6 0.0 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea Csm1 PF12539.8 CRG91467.1 - 2.6e-29 101.7 0.1 9.5e-29 99.9 0.0 1.9 2 0 0 2 2 1 1 Chromosome segregation protein Csm1/Pcs1 UPF0242 PF06785.11 CRG91467.1 - 0.0021 18.2 8.9 0.0035 17.5 8.9 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus NYD-SP28 PF14772.6 CRG91467.1 - 0.0024 17.9 1.2 0.0024 17.9 1.2 2.5 1 1 1 2 2 2 1 Sperm tail EzrA PF06160.12 CRG91467.1 - 0.0078 14.4 11.6 0.012 13.8 11.6 1.2 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Lebercilin PF15619.6 CRG91467.1 - 0.0079 15.9 13.6 0.015 15.0 13.6 1.4 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease CENP-O PF09496.10 CRG91467.1 - 0.014 15.4 5.2 0.028 14.4 5.2 1.5 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component Golgin_A5 PF09787.9 CRG91467.1 - 0.014 14.8 9.3 0.025 14.0 9.3 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 HIP1_clath_bdg PF16515.5 CRG91467.1 - 0.079 13.6 15.8 0.087 13.4 11.0 3.2 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DHR10 PF18595.1 CRG91467.1 - 0.095 12.8 17.3 0.08 13.0 14.0 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain APG6_N PF17675.1 CRG91467.1 - 0.13 12.8 16.2 0.39 11.2 16.1 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Matrilin_ccoil PF10393.9 CRG91467.1 - 0.16 11.9 1.0 2.4 8.1 0.0 2.8 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF2203 PF09969.9 CRG91467.1 - 0.18 12.6 8.6 0.21 12.3 6.4 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) TMPIT PF07851.13 CRG91467.1 - 0.22 10.8 6.2 0.36 10.0 6.2 1.4 1 0 0 1 1 1 0 TMPIT-like protein Spc7 PF08317.11 CRG91467.1 - 0.24 10.2 17.7 0.48 9.3 17.5 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 CRG91467.1 - 0.29 10.2 9.7 0.53 9.3 9.7 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 CRG91467.1 - 0.36 10.9 16.3 0.8 9.8 14.7 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 CRG91467.1 - 0.51 11.0 11.1 0.16 12.6 2.9 3.8 3 1 2 5 5 3 0 SlyX Prefoldin_2 PF01920.20 CRG91467.1 - 0.65 10.0 15.4 0.46 10.5 4.8 3.4 2 1 1 3 3 3 0 Prefoldin subunit Rootletin PF15035.6 CRG91467.1 - 0.66 10.0 12.5 1.3 9.0 12.5 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion GAS PF13851.6 CRG91467.1 - 0.75 9.1 15.5 2 7.7 13.3 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding XhlA PF10779.9 CRG91467.1 - 0.79 10.0 9.8 0.077 13.2 3.3 2.4 2 0 0 2 2 2 0 Haemolysin XhlA DUF4094 PF13334.6 CRG91467.1 - 0.92 10.0 9.3 3.9 7.9 7.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) MSP1_C PF07462.11 CRG91467.1 - 0.94 8.1 15.9 0.0039 16.0 5.9 1.8 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus Bacillus_HBL PF05791.11 CRG91467.1 - 1 9.1 10.3 4 7.2 7.8 2.6 3 1 0 3 3 2 0 Bacillus haemolytic enterotoxin (HBL) FlaC_arch PF05377.11 CRG91467.1 - 1.1 9.7 4.5 3.1 8.3 0.4 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) CENP-K PF11802.8 CRG91467.1 - 1.2 8.6 8.9 2.2 7.8 8.9 1.3 1 0 0 1 1 1 0 Centromere-associated protein K PKcGMP_CC PF16808.5 CRG91467.1 - 1.7 8.6 8.3 0.18 11.7 2.3 2.5 2 1 1 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Sec34 PF04136.15 CRG91467.1 - 2.2 8.1 9.9 4.3 7.2 8.8 1.9 1 1 0 2 2 2 0 Sec34-like family DUF5094 PF17015.5 CRG91467.1 - 2.6 8.1 0.0 2.6 8.1 0.0 4.1 3 2 1 4 4 2 0 Domain of unknown function (DUF5094) DUF641 PF04859.12 CRG91467.1 - 2.6 8.4 12.0 3.3 8.1 9.1 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) TMF_TATA_bd PF12325.8 CRG91467.1 - 2.7 8.3 15.3 1.1 9.5 7.4 3.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 CRG91467.1 - 2.9 8.0 18.4 33 4.6 13.6 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding OmpH PF03938.14 CRG91467.1 - 3 8.2 18.5 1.7e+02 2.5 18.5 3.0 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4446 PF14584.6 CRG91467.1 - 3.9 7.5 9.0 2.3 8.2 3.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) Syntaxin-6_N PF09177.11 CRG91467.1 - 4.2 8.0 12.3 31 5.2 0.7 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal NPV_P10 PF05531.12 CRG91467.1 - 4.3 7.9 8.6 5.8 7.5 2.6 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 CRG91467.1 - 4.8 7.5 8.0 13 6.1 0.5 2.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ZapB PF06005.12 CRG91467.1 - 4.9 7.7 13.3 31 5.1 6.8 2.9 1 1 1 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 CRG91467.1 - 5.6 7.0 7.0 16 5.6 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.18 CRG91467.1 - 7.7 5.7 6.4 14 4.9 6.4 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ABC_tran_CTD PF16326.5 CRG91467.1 - 9 6.6 14.1 4.7 7.5 1.3 4.0 2 1 1 3 3 3 0 ABC transporter C-terminal domain Bap31_Bap29_C PF18035.1 CRG91467.1 - 9 6.4 15.1 77 3.4 1.7 4.1 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain HlyD_2 PF12700.7 CRG91467.1 - 9.1 4.9 9.2 14 4.3 9.2 1.2 1 0 0 1 1 1 0 HlyD family secretion protein HAUS-augmin3 PF14932.6 CRG91467.1 - 9.2 5.8 14.7 20 4.6 14.4 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 TPR_MLP1_2 PF07926.12 CRG91467.1 - 9.3 6.3 22.7 5.8 7.0 18.6 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 CRG91467.1 - 9.5 6.3 12.0 19 5.3 11.4 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus LIP PF03583.14 CRG91468.1 - 8.3e-81 271.4 0.1 1.1e-80 271.0 0.1 1.1 1 0 0 1 1 1 1 Secretory lipase NPP1 PF05630.11 CRG91469.1 - 3.4e-61 206.8 0.0 3.9e-61 206.6 0.0 1.0 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) PigN PF04987.14 CRG91470.1 - 3.1e-159 530.7 39.3 4.2e-159 530.3 36.3 2.0 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Sulfatase PF00884.23 CRG91470.1 - 4.1e-08 33.0 0.1 6.3e-08 32.4 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CRG91470.1 - 1.6e-07 31.2 3.2 5.1e-06 26.3 3.1 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Fungal_trans PF04082.18 CRG91471.1 - 1.5e-36 125.8 0.0 3.2e-36 124.7 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91471.1 - 0.027 14.6 3.3 0.05 13.7 3.3 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_2 PF12796.7 CRG91472.1 - 2.3e-105 345.3 33.1 3.3e-17 62.8 0.3 8.2 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG91472.1 - 8.4e-65 207.0 1.9 0.00052 20.3 0.0 14.5 14 0 0 14 14 14 13 Ankyrin repeat Ank PF00023.30 CRG91472.1 - 1e-64 212.3 14.1 2.8e-05 24.3 0.1 14.5 14 0 0 14 14 14 13 Ankyrin repeat Ank_4 PF13637.6 CRG91472.1 - 1.3e-56 188.2 6.9 2.8e-08 34.1 0.0 10.1 3 3 8 11 11 11 11 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG91472.1 - 1.3e-43 146.4 6.4 1.8e-07 31.3 0.0 8.8 3 1 7 11 11 11 10 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 CRG91472.1 - 5.8e-11 42.1 0.0 1.5e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG91472.1 - 0.00013 21.9 0.0 0.00045 20.2 0.1 1.9 2 0 0 2 2 2 1 NACHT domain Cys_Met_Meta_PP PF01053.20 CRG91473.1 - 5.9e-142 472.7 0.0 6.9e-142 472.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CRG91473.1 - 4.3e-07 29.4 0.0 7.2e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CRG91473.1 - 2e-05 24.1 0.1 6.4e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 CRG91473.1 - 2.1e-05 23.2 0.1 0.00012 20.8 0.1 1.9 1 1 0 1 1 1 1 Methionine gamma-lyase Aminotran_5 PF00266.19 CRG91473.1 - 2.9e-05 23.2 0.1 5.5e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 CRG91473.1 - 0.0027 17.0 0.1 0.012 14.9 0.1 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase IBR PF01485.21 CRG91475.1 - 0.00035 20.7 6.6 0.00035 20.7 6.6 4.9 3 2 1 4 4 4 3 IBR domain, a half RING-finger domain Herpes_V23 PF01802.17 CRG91475.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein DUF3648 PF12364.8 CRG91475.1 - 0.59 10.4 8.4 2.7 8.2 7.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3648) NACHT PF05729.12 CRG91478.1 - 3.5e-11 43.3 0.1 8e-11 42.1 0.1 1.6 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 CRG91478.1 - 5.1e-11 42.3 0.2 2e-10 40.3 0.2 2.0 2 1 0 2 2 2 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG91478.1 - 1e-09 39.0 0.3 4.4e-09 37.0 0.2 2.2 2 0 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 CRG91478.1 - 0.0016 18.7 0.0 0.0046 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CRG91478.1 - 0.0052 16.7 0.1 0.014 15.3 0.1 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 CRG91478.1 - 0.006 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 CRG91478.1 - 0.01 16.2 0.0 0.031 14.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PIF1 PF05970.14 CRG91478.1 - 0.051 12.7 0.1 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 PIF1-like helicase AAA_24 PF13479.6 CRG91478.1 - 0.085 12.6 0.1 5.8 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 CRG91478.1 - 0.089 12.0 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain TrmO_C PF18389.1 CRG91478.1 - 0.17 12.0 0.2 0.59 10.3 0.2 1.9 1 0 0 1 1 1 0 TrmO C-terminal domain AAA_18 PF13238.6 CRG91478.1 - 0.18 12.4 0.1 1.2 9.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain UBN_AB PF14075.6 CRG91479.1 - 9.1 5.9 9.3 0.31 10.7 3.0 1.7 2 0 0 2 2 2 0 Ubinuclein conserved middle domain Bac_surface_Ag PF01103.23 CRG91480.1 - 1.2e-40 140.0 0.0 1.7e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Surface antigen Yip1 PF04893.17 CRG91480.1 - 0.00017 21.4 16.1 0.0018 18.0 8.9 2.3 2 0 0 2 2 2 2 Yip1 domain ARS2 PF04959.13 CRG91480.1 - 2.6 8.4 5.3 6.1 7.2 5.3 1.5 1 0 0 1 1 1 0 Arsenite-resistance protein 2 UFD1 PF03152.14 CRG91481.1 - 4.4e-29 101.2 0.0 3.6e-25 88.4 0.0 3.2 2 1 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 CRG91481.1 - 3.1e-07 30.5 0.3 3.1e-07 30.5 0.3 2.5 3 0 0 3 3 3 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zf-FPG_IleRS PF06827.14 CRG91481.1 - 0.055 13.3 4.6 1 9.3 0.4 3.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS zf_C2H2_10 PF18414.1 CRG91481.1 - 1.3 8.7 4.9 11 5.7 0.4 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger F-box-like PF12937.7 CRG91482.1 - 0.13 12.1 0.1 0.13 12.1 0.1 2.2 2 0 0 2 2 2 0 F-box-like AAA PF00004.29 CRG91483.1 - 5e-44 149.9 0.0 8.3e-44 149.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG91483.1 - 4.1e-14 52.1 0.0 1e-13 50.9 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 CRG91483.1 - 1.5e-07 31.7 0.0 2.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CRG91483.1 - 4.6e-07 29.9 0.0 1.2e-06 28.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG91483.1 - 1e-06 29.2 0.0 4.3e-05 24.0 0.0 2.8 2 1 1 3 3 3 1 AAA ATPase domain Prot_ATP_ID_OB PF16450.5 CRG91483.1 - 2.5e-06 27.4 2.3 6.4e-06 26.0 2.3 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_22 PF13401.6 CRG91483.1 - 1.5e-05 25.3 0.1 0.0063 16.8 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 CRG91483.1 - 6.3e-05 22.8 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 CRG91483.1 - 0.00048 20.7 0.0 0.029 14.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 CRG91483.1 - 0.0011 18.8 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 CRG91483.1 - 0.0011 18.2 0.0 0.0023 17.2 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 CRG91483.1 - 0.002 18.3 0.0 0.004 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 CRG91483.1 - 0.0052 16.6 0.0 0.015 15.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 CRG91483.1 - 0.0079 15.6 0.0 0.019 14.3 0.0 1.6 1 0 0 1 1 1 1 KaiC Mg_chelatase PF01078.21 CRG91483.1 - 0.0084 15.5 0.1 0.018 14.4 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 CRG91483.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 CRG91483.1 - 0.011 15.9 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 CRG91483.1 - 0.022 13.9 0.0 0.038 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 CRG91483.1 - 0.022 14.4 0.0 0.094 12.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain PhoH PF02562.16 CRG91483.1 - 0.026 14.0 0.0 0.1 12.1 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 CRG91483.1 - 0.029 13.9 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CRG91483.1 - 0.038 14.4 0.0 0.069 13.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 CRG91483.1 - 0.039 13.7 0.0 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 CRG91483.1 - 0.04 13.9 0.0 0.069 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain HR1 PF02185.16 CRG91483.1 - 0.048 13.8 0.6 0.11 12.6 0.6 1.6 1 0 0 1 1 1 0 Hr1 repeat AAA_25 PF13481.6 CRG91483.1 - 0.056 13.0 0.1 0.21 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain Prot_ATP_OB_N PF17758.1 CRG91483.1 - 0.069 12.8 0.1 0.24 11.1 0.1 2.0 1 1 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain Parvo_NS1 PF01057.17 CRG91483.1 - 0.091 11.8 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 DUF2072 PF09845.9 CRG91483.1 - 0.13 12.5 0.1 0.25 11.6 0.1 1.4 1 0 0 1 1 1 0 Zn-ribbon containing protein Zeta_toxin PF06414.12 CRG91483.1 - 0.16 11.2 0.0 0.28 10.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Na_Ca_ex PF01699.24 CRG91484.1 - 4e-20 72.3 35.6 2.7e-16 59.9 12.7 3.8 5 1 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 CRG91484.1 - 4.3e-12 46.5 10.8 4.3e-12 46.5 10.8 4.5 5 0 0 5 5 5 1 Inner membrane component domain Nic96 PF04097.14 CRG91485.1 - 4.7e-215 715.7 0.0 6.3e-215 715.3 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.6 CRG91485.1 - 1.6 9.6 24.3 3.6 8.5 0.3 2.8 2 0 0 2 2 2 0 Nucleoporin FG repeat region COX16 PF14138.6 CRG91486.1 - 2e-30 105.1 0.1 2.5e-30 104.8 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Y_phosphatase PF00102.27 CRG91487.1 - 7.2e-61 205.7 0.2 8.3e-60 202.3 0.2 2.1 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 CRG91487.1 - 1.7e-07 31.7 0.0 4.9e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Rhodanese-like domain DSPc PF00782.20 CRG91487.1 - 0.0077 16.0 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 CRG91487.1 - 0.018 15.0 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family F-box-like PF12937.7 CRG91488.1 - 0.0001 22.1 0.1 0.00024 20.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG91488.1 - 0.0013 18.6 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 F-box domain Oxidored_q3 PF00499.20 CRG91489.1 - 0.053 13.2 0.0 0.053 13.2 0.0 1.3 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 FGGY_C PF02782.16 CRG91490.1 - 2.4e-50 171.0 0.0 4.2e-50 170.2 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 CRG91490.1 - 6.3e-23 81.6 0.8 1.3e-21 77.3 0.1 2.6 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 CRG91490.1 - 0.0067 15.9 0.1 0.049 13.1 0.0 2.2 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family DEDD_Tnp_IS110 PF01548.17 CRG91490.1 - 0.16 11.9 1.3 1.3 8.9 0.3 2.4 2 0 0 2 2 2 0 Transposase Swi3 PF07962.12 CRG91491.1 - 1e-35 121.5 0.9 1.5e-35 121.0 0.9 1.2 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 NADH-u_ox-rdase PF10785.9 CRG91492.1 - 3.7e-31 107.6 0.1 5.6e-31 107.1 0.1 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 CRG91492.1 - 8.3e-26 89.8 0.1 1.1e-25 89.4 0.1 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit PI3_PI4_kinase PF00454.27 CRG91493.1 - 8.4e-50 169.9 0.0 1.8e-49 168.9 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 CRG91493.1 - 3e-33 115.5 0.9 6.8e-33 114.3 0.9 1.6 1 0 0 1 1 1 1 FAT domain UME PF08064.13 CRG91493.1 - 1.9e-31 108.0 2.2 7.3e-31 106.1 0.1 3.3 4 0 0 4 4 4 1 UME (NUC010) domain TPR_19 PF14559.6 CRG91493.1 - 0.035 14.6 1.4 0.5 10.9 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 CRG91493.1 - 0.055 13.9 4.0 0.2 12.1 0.0 3.4 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_14 PF13428.6 CRG91493.1 - 0.061 14.2 4.9 23 6.2 0.0 4.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 CRG91493.1 - 0.16 12.1 1.9 63 3.9 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA PF00004.29 CRG91494.1 - 1.2e-63 213.4 0.0 1.1e-40 139.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG91494.1 - 9.1e-14 51.0 1.1 5.6e-08 32.5 0.3 3.0 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 CRG91494.1 - 1.5e-10 41.7 1.8 0.00046 20.6 0.1 4.1 3 2 1 4 4 3 2 AAA ATPase domain Bac_DnaA PF00308.18 CRG91494.1 - 5.1e-08 33.0 0.0 2.2e-06 27.7 0.0 2.5 2 1 0 2 2 2 1 Bacterial dnaA protein AAA_5 PF07728.14 CRG91494.1 - 5.8e-08 32.8 0.7 0.0019 18.2 0.1 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CRG91494.1 - 8.8e-07 28.8 0.0 0.044 13.5 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein RuvB_N PF05496.12 CRG91494.1 - 1.4e-06 28.2 0.0 0.0014 18.4 0.0 3.1 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 CRG91494.1 - 4.9e-06 26.6 0.0 0.054 13.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 CRG91494.1 - 5.1e-06 26.1 0.0 0.13 11.8 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 CRG91494.1 - 6.2e-06 26.5 2.5 0.28 11.5 0.2 4.3 2 2 1 4 4 4 2 AAA domain AAA_28 PF13521.6 CRG91494.1 - 1.1e-05 25.7 0.1 0.089 13.0 0.1 2.9 2 1 0 2 2 2 2 AAA domain AAA_2 PF07724.14 CRG91494.1 - 2.4e-05 24.5 0.0 0.0088 16.2 0.0 3.0 2 2 0 2 2 2 1 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 CRG91494.1 - 3.2e-05 23.9 0.0 0.0024 17.9 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain ATPase_2 PF01637.18 CRG91494.1 - 0.00015 21.8 1.0 0.11 12.4 0.1 3.7 2 2 2 4 4 4 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 CRG91494.1 - 0.00017 21.8 0.3 0.36 11.0 0.0 3.1 3 1 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 CRG91494.1 - 0.0002 21.7 0.0 0.98 9.8 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 CRG91494.1 - 0.00029 21.4 0.0 0.38 11.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CRG91494.1 - 0.00034 19.9 0.1 0.051 12.8 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_24 PF13479.6 CRG91494.1 - 0.00045 20.0 0.0 0.064 13.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 CRG91494.1 - 0.001 18.5 0.0 0.34 10.3 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 CRG91494.1 - 0.0022 18.0 1.7 0.14 12.1 0.3 3.7 3 1 1 5 5 4 1 NACHT domain Toprim_4 PF13662.6 CRG91494.1 - 0.0024 18.3 0.0 0.74 10.3 0.0 2.8 2 0 0 2 2 2 1 Toprim domain AAA_25 PF13481.6 CRG91494.1 - 0.0027 17.3 1.1 4.6 6.8 0.0 3.3 2 2 1 3 3 3 1 AAA domain Sigma54_activ_2 PF14532.6 CRG91494.1 - 0.0036 17.4 0.0 0.054 13.6 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain DUF815 PF05673.13 CRG91494.1 - 0.011 14.9 0.0 3.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TsaE PF02367.17 CRG91494.1 - 0.014 15.4 0.0 6.3 6.8 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 CRG91494.1 - 0.017 14.9 0.0 10 5.8 0.0 2.9 2 1 0 2 2 2 0 Sigma-54 interaction domain SRPRB PF09439.10 CRG91494.1 - 0.022 14.2 0.1 0.52 9.7 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit CDC48_N PF02359.18 CRG91494.1 - 0.034 14.3 0.0 0.13 12.5 0.0 2.0 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), N-terminal domain ABC_tran PF00005.27 CRG91494.1 - 0.037 14.5 0.0 7.4 7.1 0.0 2.9 3 0 0 3 3 2 0 ABC transporter AAA_19 PF13245.6 CRG91494.1 - 0.07 13.5 0.3 4 7.8 0.2 3.0 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 CRG91494.1 - 0.074 12.9 0.0 1.7 8.5 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 CRG91494.1 - 0.077 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 CRG91494.1 - 0.085 12.6 0.0 16 5.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.10 CRG91494.1 - 0.088 12.8 0.1 3.9 7.5 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain TniB PF05621.11 CRG91494.1 - 0.098 12.1 0.0 14 5.1 0.0 3.0 3 0 0 3 3 3 0 Bacterial TniB protein ATPase PF06745.13 CRG91494.1 - 0.13 11.6 0.4 23 4.2 0.1 3.0 2 1 1 3 3 3 0 KaiC AAA_13 PF13166.6 CRG91494.1 - 0.2 10.3 0.1 0.34 9.5 0.1 1.3 1 0 0 1 1 1 0 AAA domain NCA2 PF08637.10 CRG91495.1 - 1e-90 303.9 0.0 6.4e-90 301.2 0.0 2.0 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 Ras PF00071.22 CRG91495.1 - 4.6e-64 214.9 0.0 8.5e-64 214.0 0.0 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG91495.1 - 7e-33 113.4 0.0 1.7e-32 112.1 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG91495.1 - 2.5e-12 46.6 0.1 4.6e-12 45.7 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 CRG91495.1 - 0.00028 20.5 0.1 0.00058 19.4 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 CRG91495.1 - 0.0014 18.0 0.0 0.0037 16.6 0.0 1.7 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 CRG91495.1 - 0.021 14.7 0.1 8.6 6.2 0.0 2.7 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 CRG91495.1 - 0.044 13.9 0.0 0.13 12.3 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase FA_hydroxylase PF04116.13 CRG91496.1 - 4.8e-26 91.7 16.4 4.8e-26 91.7 16.4 2.0 3 0 0 3 3 3 1 Fatty acid hydroxylase superfamily MARVEL PF01284.23 CRG91497.1 - 2e-15 57.1 12.6 2.5e-15 56.8 12.6 1.1 1 0 0 1 1 1 1 Membrane-associating domain FRB_dom PF08771.11 CRG91498.1 - 0.14 12.6 0.0 0.39 11.2 0.0 1.8 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain adh_short PF00106.25 CRG91499.1 - 4e-19 68.9 0.0 1.6e-17 63.6 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91499.1 - 1.2e-12 47.9 0.1 5.9e-11 42.4 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91499.1 - 1.4e-06 28.3 0.0 2.4e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG91500.1 - 5.7e-06 26.3 0.0 9e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG91500.1 - 8e-05 22.3 0.0 0.00018 21.1 0.0 1.6 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 CRG91500.1 - 0.013 14.9 0.0 0.053 13.0 0.0 2.0 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short_C2 PF13561.6 CRG91500.1 - 0.023 14.2 0.0 0.033 13.8 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase YkuD PF03734.14 CRG91501.1 - 0.1 13.0 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 L,D-transpeptidase catalytic domain Sugar_tr PF00083.24 CRG91503.1 - 1.9e-110 369.8 24.6 2.2e-110 369.6 24.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91503.1 - 1.2e-19 70.5 34.8 1.6e-14 53.6 8.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fer4_13 PF13370.6 CRG91504.1 - 9.1 6.9 6.7 49 4.6 1.4 4.1 3 2 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Clr5 PF14420.6 CRG91505.1 - 4.4e-13 49.2 0.2 1.1e-12 48.0 0.2 1.7 1 0 0 1 1 1 1 Clr5 domain WD40 PF00400.32 CRG91505.1 - 0.00022 21.9 2.3 0.11 13.4 0.1 5.2 6 0 0 6 6 6 1 WD domain, G-beta repeat FAD-oxidase_C PF02913.19 CRG91507.1 - 1.8e-62 211.2 0.1 2.6e-62 210.7 0.1 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 CRG91507.1 - 6.4e-38 129.6 0.0 1.1e-37 128.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain ADH_N PF08240.12 CRG91508.1 - 3.3e-33 113.8 0.1 7.3e-33 112.7 0.1 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG91508.1 - 8.2e-22 77.6 0.2 1.3e-21 76.9 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 CRG91508.1 - 1.2e-06 28.2 0.2 2.4e-06 27.2 0.2 1.5 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 CRG91508.1 - 0.001 18.4 0.4 0.0014 17.9 0.4 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 CRG91508.1 - 0.0018 17.9 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 CRG91508.1 - 0.01 16.5 0.0 0.022 15.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N_2 PF13602.6 CRG91508.1 - 0.011 16.7 0.0 0.032 15.3 0.0 1.7 1 1 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG91508.1 - 0.057 12.8 0.0 0.099 12.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FtsJ PF01728.19 CRG91508.1 - 0.094 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 CRG91508.1 - 0.17 11.2 0.1 0.27 10.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ras PF00071.22 CRG91509.1 - 2.7e-39 134.4 0.0 4.7e-39 133.6 0.0 1.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 CRG91509.1 - 5e-28 97.7 0.0 7.7e-28 97.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 CRG91509.1 - 5.3e-10 39.0 0.0 3.5e-09 36.3 0.0 1.9 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 CRG91509.1 - 0.00028 20.9 0.0 0.00048 20.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 CRG91509.1 - 0.0012 18.3 0.0 0.0017 17.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 CRG91509.1 - 0.0027 17.2 0.0 0.0054 16.2 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 CRG91509.1 - 0.0038 17.1 0.0 0.016 15.1 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 CRG91509.1 - 0.0072 16.5 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 CRG91509.1 - 0.0094 15.5 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 CRG91509.1 - 0.018 15.4 0.1 0.039 14.3 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CRG91509.1 - 0.058 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 CRG91509.1 - 0.083 13.4 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 CRG91509.1 - 0.084 12.8 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 CRG91509.1 - 0.1 12.0 0.0 0.32 10.4 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein Sigma54_activat PF00158.26 CRG91509.1 - 0.11 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 CRG91509.1 - 0.11 12.9 0.0 0.83 10.1 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 CRG91509.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 CRG91509.1 - 0.17 11.6 0.0 0.95 9.2 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein PduV-EutP PF10662.9 CRG91509.1 - 0.2 11.4 0.0 0.98 9.2 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Na_Ca_ex PF01699.24 CRG91511.1 - 1.6e-38 132.0 49.2 1.2e-21 77.3 20.8 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Draxin PF15550.6 CRG91511.1 - 1 9.2 5.7 2 8.2 5.7 1.4 1 0 0 1 1 1 0 Draxin bZIP_1 PF00170.21 CRG91513.1 - 3.3e-05 23.9 2.8 3.7e-05 23.7 0.8 2.0 2 0 0 2 2 2 1 bZIP transcription factor Malic_M PF03949.15 CRG91514.1 - 3.9e-91 304.9 0.0 5.1e-91 304.5 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 CRG91514.1 - 3.5e-63 212.7 0.2 7.4e-63 211.6 0.0 1.6 2 0 0 2 2 2 1 Malic enzyme, N-terminal domain TrmE_N PF10396.9 CRG91514.1 - 0.021 15.1 0.9 3.7 7.9 0.0 3.2 3 1 0 3 3 3 0 GTP-binding protein TrmE N-terminus FAM220 PF15487.6 CRG91516.1 - 4.7 6.8 5.7 5.6 6.5 5.7 1.2 1 0 0 1 1 1 0 FAM220 family zf-Mss51 PF13824.6 CRG91517.1 - 3.7e-28 97.4 8.4 8.2e-28 96.3 8.4 1.6 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 CRG91517.1 - 0.0012 18.9 1.5 0.0012 18.9 1.5 1.7 2 0 0 2 2 2 1 MYND finger zf-HIT PF04438.16 CRG91517.1 - 0.34 10.8 1.9 1.3 9.0 0.2 2.2 2 0 0 2 2 2 0 HIT zinc finger Oxysterol_BP PF01237.18 CRG91518.1 - 2.8e-134 447.7 0.3 1.6e-133 445.2 0.0 2.1 2 0 0 2 2 2 1 Oxysterol-binding protein ATP12 PF07542.11 CRG91518.1 - 2.1e-39 134.5 1.2 5.1e-39 133.3 1.2 1.7 1 0 0 1 1 1 1 ATP12 chaperone protein Ank_5 PF13857.6 CRG91518.1 - 1.4e-15 57.1 0.0 8.2e-09 35.6 0.1 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG91518.1 - 4.3e-12 46.4 0.0 9.9e-08 32.5 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) PH PF00169.29 CRG91518.1 - 9.8e-11 42.1 1.9 1.8e-10 41.3 0.4 2.4 2 0 0 2 2 1 1 PH domain Ank PF00023.30 CRG91518.1 - 7.6e-10 38.8 0.0 0.0078 16.6 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 CRG91518.1 - 5.5e-09 35.5 0.0 0.017 15.6 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CRG91518.1 - 2.7e-08 34.2 0.0 0.00024 21.6 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) PH_8 PF15409.6 CRG91518.1 - 1.2e-06 28.7 2.7 1.7e-06 28.2 0.7 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 CRG91518.1 - 0.00015 22.1 1.8 0.00015 22.1 1.8 3.3 4 0 0 4 4 4 1 Pleckstrin homology domain XRN_M PF17846.1 CRG91518.1 - 0.13 11.2 2.4 0.28 10.1 2.4 1.5 1 0 0 1 1 1 0 Xrn1 helical domain LLC1 PF14945.6 CRG91518.1 - 0.44 11.1 7.9 0.041 14.5 1.9 2.4 2 0 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein Glyco_tranf_2_3 PF13641.6 CRG91519.1 - 1.7e-30 106.6 0.2 2.2e-30 106.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CRG91519.1 - 5.1e-08 32.9 0.0 8.5e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CRG91519.1 - 1.6e-06 27.7 0.0 7.7e-06 25.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 21 Membr_traf_MHD PF10540.9 CRG91520.1 - 3e-18 66.4 0.4 3e-15 56.7 0.4 2.8 1 1 0 1 1 1 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 CRG91520.1 - 1.1e-12 48.2 0.0 2.1e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 CRG91520.1 - 3.8e-06 25.8 0.5 3.4e-05 22.6 0.3 2.2 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) RNase_J_C PF17770.1 CRG91520.1 - 0.099 13.7 0.3 6.6 7.9 0.0 3.2 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain NDUF_B8 PF05821.11 CRG91521.1 - 2.8e-09 37.1 0.0 3.6e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) SNF2_N PF00176.23 CRG91522.1 - 1.2e-66 224.8 0.6 2.1e-66 224.0 0.6 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG91522.1 - 7.1e-20 71.4 0.0 3.3e-19 69.3 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG91522.1 - 4e-10 40.0 0.0 1e-09 38.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.13 CRG91522.1 - 2e-08 34.4 10.7 2e-08 34.4 10.7 3.2 3 0 0 3 3 3 1 HSA DEAD PF00270.29 CRG91522.1 - 1.8e-05 24.6 0.0 0.00013 21.8 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Clr5 PF14420.6 CRG91523.1 - 7.2e-13 48.5 1.4 1.4e-12 47.6 1.4 1.5 1 0 0 1 1 1 1 Clr5 domain ADH_zinc_N PF00107.26 CRG91524.1 - 5.1e-28 97.6 0.6 8.3e-28 97.0 0.6 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG91524.1 - 3.7e-10 41.0 0.0 6.6e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91524.1 - 2.3e-06 27.4 0.0 9.6e-06 25.4 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CRG91524.1 - 0.03 13.8 0.2 0.041 13.4 0.2 1.2 1 0 0 1 1 1 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 CRG91524.1 - 0.06 12.6 0.4 0.095 12.0 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HupF_HypC PF01455.18 CRG91524.1 - 0.18 12.0 0.2 0.69 10.1 0.0 2.1 2 0 0 2 2 2 0 HupF/HypC family Pep_deformylase PF01327.21 CRG91524.1 - 0.19 11.3 0.0 0.32 10.6 0.0 1.3 1 0 0 1 1 1 0 Polypeptide deformylase Ribonuc_L-PSP PF01042.21 CRG91525.1 - 8.5e-39 132.3 0.2 1e-38 132.1 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Pribosyltran PF00156.27 CRG91527.1 - 3.3e-16 59.2 0.0 4.6e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CRG91527.1 - 0.0079 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Glyco_hydro_47 PF01532.20 CRG91528.1 - 5.8e-114 381.5 0.0 7.6e-114 381.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MgtE PF01769.16 CRG91528.1 - 0.11 12.8 1.2 0.23 11.8 0.6 1.7 2 0 0 2 2 2 0 Divalent cation transporter WD40 PF00400.32 CRG91529.1 - 1.1e-41 140.0 9.5 6.9e-06 26.7 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG91529.1 - 1.9e-11 44.1 0.1 0.0062 16.8 0.1 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 CRG91529.1 - 0.022 13.5 0.7 1.6 7.4 0.1 2.5 1 1 0 2 2 2 0 Nup133 N terminal like WD40_like PF17005.5 CRG91529.1 - 0.027 13.8 0.0 9.6 5.4 0.1 3.2 2 1 2 4 4 4 0 WD40-like domain Ge1_WD40 PF16529.5 CRG91529.1 - 0.05 12.6 0.0 2.8 6.8 0.0 3.2 3 2 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 CRG91529.1 - 0.11 11.0 0.1 0.99 7.9 0.0 2.2 2 1 1 3 3 3 0 Cytochrome D1 heme domain Nup160 PF11715.8 CRG91529.1 - 0.16 10.6 0.4 7.1 5.1 0.0 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DND1_DSRM PF14709.7 CRG91531.1 - 0.055 13.7 0.2 0.25 11.6 0.2 2.2 1 1 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 RRM_1 PF00076.22 CRG91532.1 - 1.4e-44 149.8 0.0 2.6e-16 59.2 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 CRG91532.1 - 0.00041 20.3 0.0 0.0049 16.8 0.0 2.6 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 CRG91532.1 - 0.001 19.1 0.0 0.0041 17.2 0.0 1.9 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.5 CRG91532.1 - 0.0055 16.8 0.1 0.16 12.1 0.0 2.8 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 CRG91532.1 - 0.009 15.8 0.0 0.2 11.5 0.0 2.6 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_5 PF13893.6 CRG91532.1 - 0.049 13.2 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFB6 PF17110.5 CRG91533.1 - 6e-56 188.9 0.0 8.8e-56 188.3 0.0 1.2 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH CENP-B_dimeris PF09026.10 CRG91533.1 - 0.01 16.2 5.1 0.01 16.2 5.1 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 CRG91533.1 - 8.9 4.3 6.0 12 3.9 6.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi RRM_Rrp7 PF17799.1 CRG91534.1 - 1.8e-29 102.6 0.0 2.8e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 CRG91534.1 - 1.1e-28 99.8 5.3 1.1e-28 99.8 5.3 2.3 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Dak1_2 PF13684.6 CRG91534.1 - 0.054 12.6 0.1 0.089 11.9 0.1 1.3 1 0 0 1 1 1 0 Dihydroxyacetone kinase family Rad51 PF08423.11 CRG91535.1 - 5.2e-112 373.2 0.0 6.8e-112 372.9 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 CRG91535.1 - 2.7e-11 43.4 0.0 3.7e-11 43.0 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 CRG91535.1 - 2.4e-07 31.2 0.6 6.7e-07 29.8 0.1 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 CRG91535.1 - 2.8e-07 30.1 0.0 6.4e-07 29.0 0.0 1.7 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 CRG91535.1 - 6.4e-05 22.6 0.0 9.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Phage_HK97_TLTM PF06120.11 CRG91535.1 - 0.075 12.2 0.0 5 6.2 0.0 2.2 2 0 0 2 2 2 0 Tail length tape measure protein AAA_24 PF13479.6 CRG91535.1 - 0.095 12.4 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain zf-CCHC PF00098.23 CRG91536.1 - 2.5e-43 144.2 58.4 2.7e-07 30.4 1.1 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 CRG91536.1 - 1.9e-08 33.9 41.2 0.19 11.5 0.9 7.1 7 0 0 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.6 CRG91536.1 - 3.2e-06 27.0 43.7 0.0084 16.0 0.2 6.9 4 2 2 6 6 6 4 Zinc knuckle zf-CCHC_5 PF14787.6 CRG91536.1 - 0.0016 18.1 42.7 0.021 14.5 0.8 7.1 4 2 3 7 7 7 5 GAG-polyprotein viral zinc-finger UDPGP PF01704.18 CRG91537.1 - 1.2e-56 192.2 0.0 1.6e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 CRG91537.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain Pro_isomerase PF00160.21 CRG91538.1 - 2.8e-35 121.9 0.0 4.2e-35 121.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 CRG91538.1 - 3.2e-15 55.7 0.1 1.7e-14 53.4 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_S24e PF01282.19 CRG91540.1 - 2.1e-35 120.5 0.2 3.6e-35 119.7 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S24e RRXRR PF14239.6 CRG91540.1 - 0.0043 16.9 2.4 0.0055 16.6 2.4 1.2 1 1 0 1 1 1 1 RRXRR protein Methyltransf_16 PF10294.9 CRG91541.1 - 1.8e-20 73.4 0.0 2.5e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 CRG91541.1 - 0.0011 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 CRG91541.1 - 0.012 16.3 0.0 0.02 15.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 CRG91541.1 - 0.016 15.0 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MethyltransfD12 PF02086.15 CRG91541.1 - 0.045 13.4 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase RPA43_OB PF17875.1 CRG91542.1 - 6.6e-40 136.6 9.2 1.1e-39 135.9 0.0 3.2 3 0 0 3 3 3 1 RPA43 OB domain in RNA Pol I Zn_clus PF00172.18 CRG91542.1 - 2.5e-08 33.9 13.1 4.7e-08 33.0 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SHS2_Rpb7-N PF03876.17 CRG91542.1 - 0.00022 21.5 0.0 0.00042 20.6 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DnaJ PF00226.31 CRG91543.1 - 1.5e-12 47.5 0.0 2.5e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain RraA-like PF03737.15 CRG91543.1 - 0.17 12.0 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Aldolase/RraA INO80_Ies4 PF08193.11 CRG91544.1 - 7.7e-63 212.7 16.4 9.9e-63 212.4 16.4 1.1 1 0 0 1 1 1 1 INO80 complex subunit Ies4 ADH_zinc_N PF00107.26 CRG91545.1 - 1.7e-19 70.1 0.0 2.7e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 CRG91545.1 - 8.8e-18 64.2 0.0 1.7e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 CRG91545.1 - 1.2e-07 32.9 0.0 2.1e-07 32.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase MT0933_antitox PF14013.6 CRG91545.1 - 0.092 13.1 2.6 0.15 12.3 0.5 2.2 2 0 0 2 2 2 0 MT0933-like antitoxin protein CLTH PF10607.9 CRG91546.1 - 2.4e-32 111.9 0.0 3.7e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 CRG91546.1 - 7.4e-23 80.9 0.1 1.3e-22 80.2 0.1 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 CRG91546.1 - 0.021 14.8 0.1 0.021 14.8 0.1 2.1 3 0 0 3 3 3 0 LisH DEC-1_N PF04625.13 CRG91546.1 - 0.069 12.2 1.5 5.3 6.0 4.6 2.1 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region CoA_transf_3 PF02515.17 CRG91547.1 - 4.4e-47 161.0 1.9 4.9e-47 160.8 0.3 1.9 2 0 0 2 2 2 1 CoA-transferase family III HAP1_N PF04849.13 CRG91548.1 - 0.0064 15.7 2.6 0.0064 15.7 2.6 3.5 2 1 1 3 3 3 1 HAP1 N-terminal conserved region Bap31_Bap29_C PF18035.1 CRG91548.1 - 2.1 8.4 5.7 1.7 8.7 0.2 2.9 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Phage_GP20 PF06810.11 CRG91548.1 - 4.8 7.0 20.1 1.2 9.0 2.6 3.9 2 1 2 4 4 4 0 Phage minor structural protein GP20 Pyr_redox_2 PF07992.14 CRG91549.1 - 4.4e-48 164.0 0.6 5.7e-48 163.7 0.6 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 CRG91549.1 - 3.9e-16 58.8 0.0 9.1e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 CRG91549.1 - 5.1e-16 59.0 1.9 2.3e-13 50.5 0.3 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 CRG91549.1 - 1.8e-08 34.3 0.0 6.9e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Pyr_redox_3 PF13738.6 CRG91549.1 - 2.4e-07 30.3 0.0 0.0032 16.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 CRG91549.1 - 6.3e-07 29.9 0.0 8.5e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 Reductase C-terminal K_oxygenase PF13434.6 CRG91549.1 - 0.00023 20.4 0.0 0.059 12.5 0.0 2.7 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CRG91549.1 - 0.0057 16.7 0.8 2.4 8.1 0.0 2.9 3 0 0 3 3 3 2 FAD-NAD(P)-binding DUF1188 PF06690.11 CRG91549.1 - 0.023 14.2 0.1 0.041 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) HI0933_like PF03486.14 CRG91549.1 - 0.14 10.8 0.3 4.6 5.8 0.0 2.5 3 0 0 3 3 3 0 HI0933-like protein Arrestin_N PF00339.29 CRG91551.1 - 1.6e-13 50.9 0.2 2.7e-10 40.5 0.0 2.5 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain V-ATPase_G PF03179.15 CRG91552.1 - 1e-26 93.5 11.7 4.2e-21 75.5 7.2 2.5 2 0 0 2 2 2 2 Vacuolar (H+)-ATPase G subunit V-ATPase_G_2 PF16999.5 CRG91552.1 - 2.4 8.6 8.9 2.5 8.5 5.5 2.3 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit PET117 PF15786.5 CRG91553.1 - 2.1e-24 85.5 1.7 2.4e-24 85.4 1.7 1.0 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial IDO PF01231.18 CRG91554.1 - 3.1e-35 121.8 0.0 4e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase F-box PF00646.33 CRG91555.1 - 6e-09 35.6 0.1 3.7e-08 33.1 0.0 2.5 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 CRG91555.1 - 5.7e-07 29.3 0.0 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 F-box-like TPR_2 PF07719.17 CRG91555.1 - 0.0003 20.7 13.9 0.11 12.6 1.9 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF5113 PF17140.4 CRG91555.1 - 0.00051 19.9 0.4 0.63 9.8 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF5113) BTAD PF03704.17 CRG91555.1 - 0.00095 19.6 1.7 0.019 15.4 0.3 2.3 2 0 0 2 2 2 1 Bacterial transcriptional activator domain TPR_16 PF13432.6 CRG91555.1 - 0.0065 17.1 4.3 0.27 11.9 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG91555.1 - 0.0065 16.7 1.3 0.86 9.9 0.5 2.9 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 CRG91555.1 - 0.008 16.0 8.5 4.4 7.3 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG91555.1 - 0.018 15.5 4.0 0.26 11.8 0.9 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 CRG91555.1 - 0.035 14.3 1.8 20 5.7 0.1 3.4 3 0 0 3 3 3 0 PPR repeat TPR_12 PF13424.6 CRG91555.1 - 0.047 14.0 5.0 1.3 9.3 0.8 3.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG91555.1 - 0.12 13.3 5.7 3.2 8.8 0.4 3.1 1 1 2 3 3 3 0 Tetratricopeptide repeat LRR_4 PF12799.7 CRG91555.1 - 0.2 12.2 16.9 2.7 8.6 0.0 6.4 4 2 5 9 9 9 0 Leucine Rich repeats (2 copies) ADIP PF11559.8 CRG91556.1 - 6.7e-41 139.9 14.7 6.7e-41 139.9 14.7 3.3 4 0 0 4 4 4 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 CRG91556.1 - 0.00018 21.1 12.9 0.00018 21.1 12.9 2.9 3 0 0 3 3 3 1 Golgin subfamily A member 5 AKNA PF12443.8 CRG91556.1 - 0.36 11.5 15.8 2.2 9.0 5.5 4.1 3 1 0 3 3 3 0 AT-hook-containing transcription factor TTRAP PF14203.6 CRG91556.1 - 1.5 8.8 5.0 4.1 7.5 0.2 3.3 3 1 0 3 3 3 0 Putative tranposon-transfer assisting protein Prominin PF05478.11 CRG91556.1 - 1.6 6.6 9.2 2.3 6.0 9.2 1.2 1 0 0 1 1 1 0 Prominin FUSC PF04632.12 CRG91556.1 - 2.5 6.5 14.5 0.096 11.2 6.1 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family Spc7 PF08317.11 CRG91556.1 - 9.8 4.9 23.1 0.04 12.8 12.6 2.2 3 0 0 3 3 3 0 Spc7 kinetochore protein FlaC_arch PF05377.11 CRG91556.1 - 9.9 6.6 6.4 8.7 6.8 1.1 3.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Sugar_tr PF00083.24 CRG91557.1 - 2.2e-126 422.4 24.7 2.5e-126 422.2 24.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91557.1 - 4.7e-25 88.2 37.6 2.6e-23 82.5 32.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4131 PF13567.6 CRG91557.1 - 4.9 6.8 14.2 4.5 6.9 0.0 4.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4131) RTA1 PF04479.13 CRG91558.1 - 7.4e-71 238.0 9.2 9e-71 237.8 9.2 1.0 1 0 0 1 1 1 1 RTA1 like protein DUF2207 PF09972.9 CRG91558.1 - 0.2 10.4 1.2 0.24 10.1 1.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Nucleopor_Nup85 PF07575.13 CRG91560.1 - 1.3e-22 80.1 0.0 6.9e-17 61.2 0.0 2.4 2 0 0 2 2 2 2 Nup85 Nucleoporin RNA_pol_3_Rpc31 PF11705.8 CRG91560.1 - 0.0088 16.3 16.7 0.017 15.4 16.7 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 CRG91560.1 - 0.048 11.9 11.9 0.071 11.3 11.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 CRG91560.1 - 0.42 8.8 10.8 7 4.8 10.9 2.0 2 0 0 2 2 2 0 CDC45-like protein YL1 PF05764.13 CRG91560.1 - 0.7 10.0 13.7 1.6 8.8 13.7 1.5 1 0 0 1 1 1 0 YL1 nuclear protein Trypan_PARP PF05887.11 CRG91560.1 - 2.5 8.1 11.3 6 6.8 11.3 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SDA1 PF05285.12 CRG91560.1 - 3.7 6.9 15.7 6 6.2 15.7 1.2 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 CRG91560.1 - 6.7 5.9 12.2 12 5.1 12.2 1.3 1 0 0 1 1 1 0 NOA36 protein AMPK1_CBM PF16561.5 CRG91561.1 - 9.2e-05 22.6 0.0 0.00017 21.7 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase RNA_pol_Rpb2_6 PF00562.28 CRG91562.1 - 7.9e-123 410.4 0.7 1e-122 410.0 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 CRG91562.1 - 1.6e-56 191.1 0.0 3.1e-56 190.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 CRG91562.1 - 1.2e-47 162.0 0.0 3.9e-46 157.1 0.0 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 CTNNBL PF08216.11 CRG91562.1 - 8.6e-40 135.1 0.9 2.9e-39 133.4 0.4 2.2 2 0 0 2 2 2 1 Catenin-beta-like, Arm-motif containing nuclear RNA_pol_Rpb2_7 PF04560.20 CRG91562.1 - 9.3e-33 112.5 0.0 2.6e-32 111.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 CRG91562.1 - 9.8e-25 86.5 0.1 2.4e-24 85.3 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 CRG91562.1 - 3.6e-24 84.8 0.7 1e-23 83.4 0.7 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 CRG91562.1 - 2.1e-21 76.2 0.2 9.1e-21 74.2 0.2 2.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 V-ATPase_H_N PF03224.14 CRG91562.1 - 0.0053 16.1 1.9 0.011 15.1 1.9 1.4 1 0 0 1 1 1 1 V-ATPase subunit H Arm PF00514.23 CRG91562.1 - 0.017 15.2 0.0 1.6 8.8 0.0 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Neurochondrin PF05536.11 CRG91562.1 - 0.021 13.2 0.0 0.044 12.1 0.0 1.4 1 0 0 1 1 1 0 Neurochondrin HEAT_2 PF13646.6 CRG91562.1 - 0.027 14.9 2.4 0.38 11.2 0.2 3.1 3 0 0 3 3 3 0 HEAT repeats Mo25 PF08569.11 CRG91562.1 - 0.038 13.4 0.2 0.084 12.2 0.2 1.6 1 0 0 1 1 1 0 Mo25-like RYDR_ITPR PF01365.21 CRG91562.1 - 0.048 13.1 0.5 0.3 10.5 0.5 2.1 1 1 0 1 1 1 0 RIH domain CMAS PF02353.20 CRG91562.1 - 0.16 11.3 0.0 0.31 10.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MMS19_C PF12460.8 CRG91562.1 - 0.3 10.2 2.7 1.7 7.6 0.3 2.3 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal DUF3361 PF11841.8 CRG91562.1 - 3.8 7.4 6.9 0.72 9.8 1.1 2.9 4 1 0 4 4 3 0 Domain of unknown function (DUF3361) RNB PF00773.19 CRG91563.1 - 3.5e-43 148.2 0.0 9e-30 104.1 0.0 2.5 1 1 1 2 2 2 2 RNB domain MARVEL PF01284.23 CRG91564.1 - 0.00042 20.4 16.9 0.00059 19.9 16.9 1.1 1 0 0 1 1 1 1 Membrane-associating domain SDA1 PF05285.12 CRG91565.1 - 0.0076 15.7 12.5 0.0086 15.5 12.5 1.1 1 0 0 1 1 1 1 SDA1 PPP4R2 PF09184.11 CRG91565.1 - 0.0082 15.8 10.9 0.0086 15.7 10.9 1.1 1 0 0 1 1 1 1 PPP4R2 Sigma70_ner PF04546.13 CRG91565.1 - 0.044 13.7 11.1 0.058 13.3 11.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region ThiS PF02597.20 CRG91565.1 - 0.077 13.6 9.6 0.088 13.5 0.0 3.3 2 2 0 2 2 1 0 ThiS family D123 PF07065.14 CRG91565.1 - 0.13 11.4 2.5 0.16 11.1 2.5 1.1 1 0 0 1 1 1 0 D123 Presenilin PF01080.17 CRG91565.1 - 0.41 9.4 1.1 0.43 9.3 1.1 1.1 1 0 0 1 1 1 0 Presenilin TFIIF_alpha PF05793.12 CRG91565.1 - 0.44 9.1 18.7 0.5 8.9 18.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TFB6 PF17110.5 CRG91565.1 - 0.7 9.6 5.5 1 9.1 5.5 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NOA36 PF06524.12 CRG91565.1 - 1.3 8.3 17.4 1.8 7.8 17.4 1.2 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 CRG91565.1 - 1.4 8.1 10.6 1.8 7.7 10.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 CRG91565.1 - 1.7 6.8 13.5 2 6.6 13.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Usp PF00582.26 CRG91565.1 - 1.9 9.0 5.7 3.4 8.2 5.7 1.4 1 0 0 1 1 1 0 Universal stress protein family Spot_14 PF07084.12 CRG91565.1 - 3.8 7.6 5.7 6 7.0 5.7 1.2 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 DNA_pol_phi PF04931.13 CRG91565.1 - 4.2 5.3 24.3 5 5.1 24.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Connexin PF00029.19 CRG91565.1 - 5.5 6.7 5.0 6.9 6.4 5.0 1.1 1 0 0 1 1 1 0 Connexin RRN3 PF05327.11 CRG91565.1 - 5.7 5.3 8.4 6.4 5.2 8.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RAB3GAP2_C PF14656.6 CRG91565.1 - 5.8 5.0 5.6 6.6 4.8 5.6 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Nop14 PF04147.12 CRG91565.1 - 5.8 5.0 20.3 6.9 4.7 20.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4820 PF16091.5 CRG91565.1 - 5.9 6.2 6.9 7.8 5.8 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Saw1 PF11561.8 CRG91565.1 - 8.2 5.9 6.9 10 5.6 6.9 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Cys_Met_Meta_PP PF01053.20 CRG91566.1 - 1.2e-63 215.0 0.0 2e-63 214.2 0.0 1.3 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 CRG91566.1 - 0.00093 18.2 0.1 0.006 15.6 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CRG91566.1 - 0.01 15.0 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class I and II TINF2_N PF14973.6 CRG91566.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus TRP PF06011.12 CRG91568.1 - 1.1e-39 136.4 24.9 3.6e-32 111.7 20.4 2.1 2 0 0 2 2 2 2 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 CRG91568.1 - 1.9e-21 76.9 0.1 2.9e-21 76.3 0.1 1.3 1 0 0 1 1 1 1 ML-like domain Strabismus PF06638.11 CRG91568.1 - 0.85 8.2 4.4 1.4 7.5 4.4 1.2 1 0 0 1 1 1 0 Strabismus protein Mito_carr PF00153.27 CRG91569.1 - 7.5e-59 195.7 3.8 3.9e-20 71.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Pro-kuma_activ PF09286.11 CRG91570.1 - 3.4e-46 157.1 0.0 8.4e-46 155.8 0.0 1.7 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Glyco_hydro_cc PF11790.8 CRG91571.1 - 5.2e-59 199.7 5.7 5.9e-59 199.5 5.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Haem_bd PF14376.6 CRG91571.1 - 0.18 11.7 0.1 0.27 11.2 0.1 1.3 1 0 0 1 1 1 0 Haem-binding domain DUF5127 PF17168.4 CRG91572.1 - 2.9e-75 252.9 14.0 4.9e-75 252.2 14.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 CRG91572.1 - 1.9e-74 249.1 0.9 3.3e-74 248.3 0.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 CRG91572.1 - 5.3e-63 212.4 0.5 5.3e-63 212.4 0.5 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF4964 PF16334.5 CRG91572.1 - 1.1e-06 28.0 0.4 3.4e-06 26.5 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4964) Phage_T4_gp36 PF03903.13 CRG91572.1 - 0.98 9.4 6.3 0.24 11.4 0.7 2.5 2 1 0 2 2 2 0 Phage T4 tail fibre Cerato-platanin PF07249.12 CRG91573.1 - 1.5e-36 125.1 0.2 1.7e-36 124.9 0.2 1.0 1 0 0 1 1 1 1 Cerato-platanin Sas10_Utp3 PF04000.15 CRG91574.1 - 5.9e-16 58.9 0.2 5.9e-16 58.9 0.2 2.3 3 0 0 3 3 3 1 Sas10/Utp3/C1D family EMP70 PF02990.16 CRG91575.1 - 1.8e-203 677.0 2.1 2.3e-203 676.6 2.1 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 EF-hand_7 PF13499.6 CRG91575.1 - 4.1e-22 78.4 2.8 1.1e-13 51.4 0.8 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 CRG91575.1 - 1.7e-21 74.1 9.3 2.3e-07 29.9 0.1 4.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CRG91575.1 - 1.1e-19 68.6 5.4 6.8e-06 25.6 0.1 5.0 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 CRG91575.1 - 6.2e-15 53.9 8.8 0.00029 20.2 0.1 4.7 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 CRG91575.1 - 9.1e-11 41.5 10.3 0.0011 18.8 0.4 4.3 3 2 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 CRG91575.1 - 6.2e-06 26.1 4.9 0.027 14.4 0.2 3.6 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 CRG91575.1 - 0.04 14.2 1.3 0.11 12.8 0.0 2.4 3 0 0 3 3 3 0 EF-hand domain Pex14_N PF04695.13 CRG91576.1 - 0.00022 21.9 2.2 0.0005 20.8 2.2 1.5 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Fungal_trans_2 PF11951.8 CRG91576.1 - 0.00045 19.1 0.0 0.00081 18.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91576.1 - 0.0019 18.3 2.2 0.0034 17.5 2.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_C80 PF11713.8 CRG91576.1 - 0.16 12.2 0.0 16 5.7 0.0 2.3 2 0 0 2 2 2 0 Peptidase C80 family Pkinase PF00069.25 CRG91577.1 - 1e-66 225.0 0.0 1.5e-66 224.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91577.1 - 6.5e-31 107.5 0.0 1e-30 106.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG91577.1 - 6.5e-05 22.4 0.0 9.1e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CRG91577.1 - 0.0062 15.9 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CRG91577.1 - 0.028 13.2 0.0 0.049 12.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Sec1 PF00995.23 CRG91578.1 - 1.2e-117 394.6 0.0 1.4e-117 394.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DGCR6 PF07324.11 CRG91578.1 - 0.032 13.8 0.4 0.095 12.3 0.4 1.8 1 0 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein DUF1481 PF07356.12 CRG91579.1 - 0.0073 16.1 6.5 0.0082 15.9 0.8 2.1 1 1 0 2 2 2 2 Protein of unknown function (DUF1481) FMO-like PF00743.19 CRG91580.1 - 2.1e-13 49.6 0.0 2.6e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG91580.1 - 4e-12 46.0 0.0 4e-10 39.4 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG91580.1 - 5.4e-09 35.7 0.0 5.5e-06 25.8 0.0 2.5 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG91580.1 - 3.1e-08 33.1 0.0 6.9e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 CRG91580.1 - 1.9e-05 24.7 0.2 0.0088 16.0 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CRG91580.1 - 0.007 16.0 0.1 0.65 9.5 0.1 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91580.1 - 0.014 15.6 0.6 0.079 13.2 0.2 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG91580.1 - 0.044 13.0 0.0 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Thi4 family FAD_oxidored PF12831.7 CRG91580.1 - 0.077 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase MARVEL PF01284.23 CRG91581.1 - 7.3e-10 39.0 8.8 9.6e-10 38.7 8.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain SUR7 PF06687.12 CRG91581.1 - 0.91 9.1 0.0 0.91 9.1 0.0 2.3 2 1 0 2 2 2 0 SUR7/PalI family Phage_holin_2_4 PF16082.5 CRG91581.1 - 8.7 6.2 7.4 10 5.9 2.8 2.4 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like UvdE PF03851.14 CRG91583.1 - 1.6e-113 378.5 0.0 2.8e-113 377.7 0.0 1.4 1 0 0 1 1 1 1 UV-endonuclease UvdE DUF2183 PF09949.9 CRG91583.1 - 2e-33 114.7 0.0 5.7e-33 113.2 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 CRG91583.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) Glyco_hydro_61 PF03443.14 CRG91584.1 - 0.0011 19.0 0.4 0.0093 15.9 0.0 2.6 2 1 0 2 2 2 1 Glycosyl hydrolase family 61 LPMO_10 PF03067.15 CRG91584.1 - 0.068 13.8 2.1 0.075 13.7 0.0 2.1 2 2 0 2 2 2 0 Lytic polysaccharide mono-oxygenase, cellulose-degrading PGA2 PF07543.12 CRG91585.1 - 4.4e-29 101.2 5.6 5.9e-29 100.8 5.6 1.1 1 0 0 1 1 1 1 Protein trafficking PGA2 IER PF05760.12 CRG91585.1 - 0.059 13.7 2.7 0.074 13.4 2.7 1.1 1 0 0 1 1 1 0 Immediate early response protein (IER) CENP-S PF15630.6 CRG91586.1 - 3.4e-35 120.3 0.0 4.6e-35 119.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 CRG91586.1 - 4.9e-10 39.5 0.0 6e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 CRG91586.1 - 0.00037 20.4 0.0 0.00059 19.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-18kDa PF02269.16 CRG91586.1 - 0.026 14.5 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit TFIID-31kDa PF02291.15 CRG91586.1 - 0.091 12.8 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit SLT PF01464.20 CRG91587.1 - 0.054 13.2 0.2 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Transglycosylase SLT domain Ubiq_cyt_C_chap PF03981.12 CRG91587.1 - 0.058 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone Phage_Gp17 PF17549.2 CRG91587.1 - 0.079 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Gene Product 17 DUF2477 PF10631.9 CRG91587.1 - 0.085 13.5 1.6 0.15 12.7 1.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) Pectate_lyase_3 PF12708.7 CRG91588.1 - 2.1e-69 233.7 27.0 1.3e-59 201.7 9.1 3.2 3 1 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 CRG91588.1 - 0.0068 16.1 1.2 0.069 12.9 0.0 2.7 2 0 0 2 2 2 1 N terminal extension of bacteriophage endosialidase zf-NADH-PPase PF09297.11 CRG91588.1 - 0.095 12.4 0.2 0.2 11.3 0.2 1.5 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain Antifungal_pept PF11410.8 CRG91588.1 - 0.14 12.1 1.4 0.49 10.4 1.4 1.9 1 0 0 1 1 1 0 Antifungal peptide tRNA-synt_1g PF09334.11 CRG91589.1 - 2.2e-143 477.8 1.1 1.8e-141 471.4 1.1 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 CRG91589.1 - 3.9e-07 28.7 7.9 0.00015 20.2 0.0 3.6 3 2 1 4 4 4 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CRG91589.1 - 2.5e-05 24.3 0.5 5e-05 23.3 0.5 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Atrophin-1 PF03154.15 CRG91589.1 - 1.4 7.2 10.3 1.9 6.7 10.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family BNR_2 PF13088.6 CRG91590.1 - 4.4e-12 45.9 0.0 2.5e-08 33.6 0.0 2.6 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.20 CRG91590.1 - 4.7e-07 28.9 15.5 0.19 11.9 0.3 4.9 4 0 0 4 4 4 4 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 CRG91590.1 - 0.00054 18.9 0.5 0.68 8.7 0.3 2.9 1 1 0 2 2 2 2 Sortilin, neurotensin receptor 3, WHH PF14414.6 CRG91590.1 - 0.0056 16.5 1.6 0.32 10.9 0.0 2.8 3 0 0 3 3 3 1 A nuclease of the HNH/ENDO VII superfamily with conserved WHH DUF4185 PF13810.6 CRG91590.1 - 0.079 12.2 0.8 42 3.2 0.0 3.6 1 1 3 4 4 4 0 Domain of unknown function (DUF4185) DUF4145 PF13643.6 CRG91591.1 - 0.03 14.5 0.1 0.16 12.1 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) zf-Di19 PF05605.12 CRG91591.1 - 1.6 9.1 11.1 2.1 8.7 0.7 4.5 4 0 0 4 4 4 0 Drought induced 19 protein (Di19), zinc-binding Cation_efflux PF01545.21 CRG91593.1 - 2.6e-52 177.4 8.9 4.4e-52 176.7 8.9 1.4 1 0 0 1 1 1 1 Cation efflux family Hexokinase_1 PF00349.21 CRG91593.1 - 9.6e-49 166.0 0.0 1.5e-48 165.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 CRG91593.1 - 6.1e-39 133.9 0.0 1e-38 133.2 0.0 1.4 1 0 0 1 1 1 1 Hexokinase BPD_transp_2 PF02653.16 CRG91593.1 - 3.7e-05 23.0 0.3 3.7e-05 23.0 0.3 2.1 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component Virul_fac_BrkB PF03631.15 CRG91595.1 - 0.0052 16.4 0.2 0.0052 16.4 0.2 1.5 2 0 0 2 2 2 1 Virulence factor BrkB GMC_oxred_N PF00732.19 CRG91596.1 - 1.7e-48 165.5 0.0 2.3e-48 165.1 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase NifU_N PF01592.16 CRG91596.1 - 7.2e-42 142.6 0.2 2.1e-41 141.1 0.1 1.8 2 0 0 2 2 1 1 NifU-like N terminal domain GMC_oxred_C PF05199.13 CRG91596.1 - 3.6e-34 118.4 0.1 6e-34 117.6 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 CRG91596.1 - 0.0002 20.5 0.3 0.00032 19.9 0.3 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 CRG91596.1 - 0.00041 20.1 0.6 0.0018 17.9 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG91596.1 - 0.0015 17.8 0.5 0.25 10.5 0.1 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG91596.1 - 0.0031 17.7 0.4 0.0089 16.2 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 CRG91596.1 - 0.0035 16.6 0.2 1.2 8.3 0.2 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HHH PF00633.23 CRG91596.1 - 0.051 13.5 0.1 1 9.3 0.0 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix motif FAD_binding_2 PF00890.24 CRG91596.1 - 0.094 11.8 1.9 0.089 11.9 0.6 1.6 2 0 0 2 2 2 0 FAD binding domain Trp_halogenase PF04820.14 CRG91596.1 - 0.16 10.8 0.1 0.26 10.1 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase MFS_1 PF07690.16 CRG91597.1 - 3e-33 115.2 74.1 1.4e-27 96.6 49.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91597.1 - 5.3e-06 25.6 36.8 3.7e-05 22.8 12.0 2.6 1 1 1 2 2 2 2 Sugar (and other) transporter Sugar_tr PF00083.24 CRG91598.1 - 7.3e-37 127.3 18.6 1.3e-36 126.5 18.6 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91598.1 - 4.4e-32 111.4 35.5 8.4e-26 90.7 17.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 CRG91598.1 - 1.7e-05 23.6 3.6 1.7e-05 23.6 3.6 2.4 3 0 0 3 3 3 2 Vacuole effluxer Atg22 like GST_N_3 PF13417.6 CRG91599.1 - 1.2e-15 57.6 0.0 2.2e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 CRG91599.1 - 6.2e-13 48.9 0.0 1.6e-12 47.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG91599.1 - 5.5e-12 45.8 0.1 1.6e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG91599.1 - 1.3e-08 34.9 0.2 3e-08 33.8 0.2 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG91599.1 - 2.9e-08 33.8 0.1 5.2e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 CRG91599.1 - 0.00025 21.0 0.1 0.00047 20.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG91599.1 - 0.0047 17.7 0.0 0.017 15.8 0.0 1.9 1 1 0 1 1 1 1 Glutathione S-transferase N-terminal domain Glyco_hydro_6 PF01341.17 CRG91600.1 - 2.7e-108 362.3 3.2 3.4e-108 362.0 3.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 6 Ubie_methyltran PF01209.18 CRG91600.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AAA_12 PF13087.6 CRG91601.1 - 8e-36 123.5 0.0 1.4e-35 122.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CRG91601.1 - 1.8e-11 44.4 0.0 3.1e-11 43.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG91601.1 - 1.4e-08 34.7 0.0 5.9e-06 26.1 0.0 2.6 3 0 0 3 3 3 2 AAA domain UvrD_C_2 PF13538.6 CRG91601.1 - 0.00078 19.2 0.0 0.0028 17.4 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 CRG91601.1 - 0.0041 17.5 0.0 0.011 16.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 CRG91601.1 - 0.0089 15.7 0.1 0.015 15.0 0.1 1.4 1 0 0 1 1 1 1 Thymidylate kinase ResIII PF04851.15 CRG91601.1 - 0.1 12.6 0.0 0.29 11.1 0.0 1.7 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit SAS4 PF15460.6 CRG91602.1 - 3.1e-33 113.8 7.2 3.1e-33 113.8 7.2 2.4 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 Roughex PF06020.11 CRG91602.1 - 0.27 10.3 11.4 0.49 9.4 11.4 1.4 1 0 0 1 1 1 0 Drosophila roughex protein Mem_trans PF03547.18 CRG91602.1 - 0.31 9.4 1.1 0.42 9.0 1.1 1.2 1 0 0 1 1 1 0 Membrane transport protein V_ATPase_I PF01496.19 CRG91602.1 - 6.3 4.6 13.9 9.1 4.1 13.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Aminotran_1_2 PF00155.21 CRG91603.1 - 1.2e-62 212.2 0.0 1.6e-62 211.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 CRG91603.1 - 0.00058 19.2 0.0 0.00081 18.8 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 CRG91603.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V OKR_DC_1 PF01276.20 CRG91603.1 - 0.2 10.3 0.0 0.39 9.4 0.0 1.4 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain FMN_red PF03358.15 CRG91604.1 - 5.9e-26 91.1 0.0 7.4e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 CRG91604.1 - 0.00092 19.0 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold AA_permease_2 PF13520.6 CRG91605.1 - 3.8e-48 164.4 44.8 3.4e-47 161.2 44.8 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG91605.1 - 4.4e-26 91.5 30.2 8.1e-26 90.6 30.2 1.3 1 0 0 1 1 1 1 Amino acid permease PAN_1 PF00024.26 CRG91606.1 - 8.8e-10 38.4 10.6 0.0027 17.6 0.1 3.4 2 1 0 3 3 3 3 PAN domain MANEC PF07502.14 CRG91606.1 - 0.0048 17.1 5.1 0.78 10.1 2.5 2.6 2 0 0 2 2 2 2 MANEC domain TrbC PF04956.13 CRG91606.1 - 0.012 15.8 0.0 0.026 14.7 0.0 1.5 1 0 0 1 1 1 0 TrbC/VIRB2 family SKG6 PF08693.10 CRG91606.1 - 0.014 14.8 0.3 0.026 13.9 0.3 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain NmrA PF05368.13 CRG91607.1 - 1.3e-32 113.2 0.0 1.9e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG91607.1 - 1.3e-13 51.3 0.0 1.9e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG91607.1 - 5e-05 23.6 0.0 7.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG91607.1 - 0.0028 17.2 0.0 0.0042 16.6 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 CRG91607.1 - 0.06 13.5 0.1 0.2 11.8 0.0 2.0 3 0 0 3 3 3 0 Dihydrodipicolinate reductase, N-terminus p450 PF00067.22 CRG91610.1 - 7.8e-68 229.3 0.0 1e-67 228.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF276 PF03434.13 CRG91610.1 - 0.24 10.5 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 DUF276 MIP PF00230.20 CRG91611.1 - 4.2e-32 111.7 5.1 5.7e-32 111.3 5.1 1.1 1 0 0 1 1 1 1 Major intrinsic protein Gly-zipper_Omp PF13488.6 CRG91611.1 - 2.2 8.3 6.0 1.8 8.6 0.9 2.9 2 1 0 2 2 2 0 Glycine zipper TGF_beta_GS PF08515.12 CRG91612.1 - 8.7 5.9 6.0 2.4 7.7 1.1 2.4 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif ThrE PF06738.12 CRG91614.1 - 1.5e-72 243.8 8.7 3.7e-66 222.9 0.4 2.3 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 CRG91614.1 - 2.7e-11 43.7 9.1 2.7e-11 43.7 9.1 3.3 3 1 0 3 3 3 1 Threonine/Serine exporter, ThrE tRNA_Me_trans PF03054.16 CRG91615.1 - 0.11 11.3 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Macro PF01661.21 CRG91617.1 - 1.1e-12 48.1 0.0 4.8e-12 46.0 0.0 1.8 1 1 0 1 1 1 1 Macro domain CorA PF01544.18 CRG91620.1 - 4.3e-07 29.6 0.6 9.3e-07 28.4 0.6 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein RelA_SpoT PF04607.17 CRG91621.1 - 1.8e-14 54.0 3.4 4.6e-14 52.7 3.4 1.7 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins PhaP_Bmeg PF09602.10 CRG91621.1 - 0.15 12.0 8.2 0.37 10.7 7.2 2.2 2 1 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DHDPS PF00701.22 CRG91622.1 - 1.5e-47 161.7 0.2 1.8e-47 161.4 0.2 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family MR_MLE_C PF13378.6 CRG91623.1 - 9.6e-55 185.5 0.1 1.3e-54 185.1 0.1 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 CRG91623.1 - 9.8e-19 67.7 0.0 1.9e-18 66.8 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 CRG91623.1 - 0.14 11.2 0.0 0.29 10.3 0.0 1.5 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus DUF4213 PF13938.6 CRG91623.1 - 0.16 12.2 0.1 10 6.5 0.0 2.9 3 0 0 3 3 3 0 Putative heavy-metal chelation adh_short PF00106.25 CRG91624.1 - 1.7e-50 171.2 0.1 2.5e-50 170.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91624.1 - 1.1e-49 169.1 1.0 2.3e-49 168.1 1.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91624.1 - 3.6e-13 49.8 1.1 7.6e-13 48.8 0.2 1.8 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 CRG91624.1 - 7e-07 28.9 0.0 8.3e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Glyco_transf_5 PF08323.11 CRG91624.1 - 0.0019 17.9 0.1 0.069 12.8 0.0 2.5 2 1 1 3 3 3 1 Starch synthase catalytic domain NAD_binding_7 PF13241.6 CRG91624.1 - 0.016 15.7 0.1 0.043 14.3 0.1 1.7 1 1 0 1 1 1 0 Putative NAD(P)-binding GDP_Man_Dehyd PF16363.5 CRG91624.1 - 0.017 14.5 0.1 0.025 14.0 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Glyco_transf_4 PF13439.6 CRG91624.1 - 0.028 14.4 0.0 2.2 8.2 0.0 2.8 3 0 0 3 3 3 0 Glycosyltransferase Family 4 Fungal_trans_2 PF11951.8 CRG91625.1 - 2e-16 59.8 0.7 2e-16 59.8 0.7 2.0 2 1 0 2 2 2 1 Fungal specific transcription factor domain DUF4951 PF16309.5 CRG91625.1 - 0.2 11.7 1.3 1.4 9.0 0.6 2.4 2 0 0 2 2 2 0 Domian of unknown function (DUF4951) HsbA PF12296.8 CRG91626.1 - 1e-25 90.5 10.2 1e-25 90.5 10.2 2.6 2 0 0 2 2 2 1 Hydrophobic surface binding protein A ApoLp-III PF07464.11 CRG91626.1 - 0.052 13.6 0.1 0.12 12.5 0.1 1.7 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Fungal_trans PF04082.18 CRG91627.1 - 3.7e-19 68.8 0.1 5.9e-19 68.1 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain RFC1 PF08519.12 CRG91627.1 - 0.085 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Replication factor RFC1 C terminal domain Nucleoporin_FG PF13634.6 CRG91628.1 - 0.82 10.6 15.1 2.4 9.0 10.5 2.7 1 1 1 2 2 2 0 Nucleoporin FG repeat region Glyco_hydro_49N PF17433.2 CRG91629.1 - 3.3e-47 160.6 1.9 7.5e-47 159.4 1.9 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 49 N-terminal Ig-like domain Glyco_hydro_49 PF03718.13 CRG91629.1 - 1.3e-29 102.6 1.1 1.3e-29 102.6 1.1 2.5 3 0 0 3 3 3 1 Glycosyl hydrolase family 49 B_solenoid_dext PF18841.1 CRG91629.1 - 6.9e-19 67.9 0.3 1.6e-18 66.7 0.3 1.7 1 0 0 1 1 1 1 Beta solenoid repeat from Dextranase IPU_b_solenoid PF18783.1 CRG91629.1 - 7.2e-18 64.3 0.8 7.2e-18 64.3 0.8 2.6 3 0 0 3 3 3 1 Isopullulanase beta-solenoid repeat MFS_1 PF07690.16 CRG91630.1 - 4.9e-38 130.9 51.6 1e-37 129.9 48.7 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG91630.1 - 8e-19 67.5 18.0 1.3e-18 66.8 18.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG91630.1 - 8.4e-15 54.6 13.4 8.4e-15 54.6 13.4 2.6 2 1 0 2 2 2 1 Sugar (and other) transporter Ribosomal_S28e PF01200.18 CRG91631.1 - 3e-31 107.2 2.3 3.4e-31 107.0 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e CAP_N PF01213.19 CRG91632.1 - 2.9 7.3 9.0 6.2 6.2 9.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal K_trans PF02705.16 CRG91633.1 - 1.6e-179 597.9 19.4 2.2e-179 597.4 19.4 1.2 1 0 0 1 1 1 1 K+ potassium transporter DUF805 PF05656.14 CRG91634.1 - 0.13 12.7 1.5 0.25 11.8 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF805) Phage_holin_3_6 PF07332.11 CRG91634.1 - 0.43 10.6 6.7 0.85 9.7 6.7 1.4 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Glyco_hydro_20 PF00728.22 CRG91635.1 - 2.5e-98 329.8 0.1 3.2e-98 329.4 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 CRG91635.1 - 1.6e-26 93.6 0.0 3.1e-26 92.7 0.0 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 CRG91635.1 - 5.1e-06 27.3 0.0 9.1e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 TPR_1 PF00515.28 CRG91636.1 - 4.1e-25 86.5 0.9 2.8e-09 36.4 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 CRG91636.1 - 6.2e-21 72.8 6.4 1.5e-07 31.0 0.0 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 CRG91636.1 - 2e-17 62.5 6.1 2.1e-08 33.7 0.0 4.8 4 1 1 5 5 5 3 TPR repeat TPR_16 PF13432.6 CRG91636.1 - 4.1e-15 56.1 5.2 3.4e-05 24.4 0.0 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 CRG91636.1 - 7.8e-15 54.3 7.3 3.5e-05 24.3 0.0 5.5 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 CRG91636.1 - 8.3e-14 50.6 1.1 7.4e-07 28.9 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 CRG91636.1 - 3.3e-13 49.0 2.1 0.0062 16.8 0.0 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 CRG91636.1 - 1.5e-10 40.3 0.5 0.0072 16.3 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 CRG91636.1 - 3e-10 40.5 14.4 0.00042 20.8 0.0 4.7 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG91636.1 - 2.5e-08 34.1 7.7 3.4e-06 27.2 0.4 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 CRG91636.1 - 2.6e-08 33.9 0.7 0.0068 16.5 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 CRG91636.1 - 3.3e-07 30.5 5.1 0.0058 16.9 0.0 4.2 4 1 1 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG91636.1 - 0.00064 19.9 4.8 0.021 15.0 0.3 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 CRG91636.1 - 0.0013 18.7 0.2 4.3 7.4 0.0 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 CRG91636.1 - 0.01 16.4 11.4 2.5 8.9 0.0 5.9 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_15 PF13429.6 CRG91636.1 - 0.017 14.4 9.8 0.21 10.8 1.2 2.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CRG91636.1 - 0.03 14.2 3.4 0.086 12.7 0.3 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 CRG91636.1 - 0.047 13.8 0.3 10 6.3 0.1 3.6 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain NatB_MDM20 PF09797.9 CRG91636.1 - 0.06 12.3 0.0 0.14 11.1 0.0 1.6 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit TOM20_plant PF06552.12 CRG91636.1 - 0.083 12.6 0.1 4 7.1 0.0 2.8 3 0 0 3 3 2 0 Plant specific mitochondrial import receptor subunit TOM20 DUF3094 PF11293.8 CRG91636.1 - 0.14 11.8 0.2 0.34 10.6 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) DUF1641 PF07849.11 CRG91636.1 - 0.16 11.9 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF1641) PMEI PF04043.15 CRG91636.1 - 0.21 11.9 0.8 0.9 9.9 0.0 2.2 2 0 0 2 2 2 0 Plant invertase/pectin methylesterase inhibitor DUF4192 PF13830.6 CRG91636.1 - 4.7 7.2 9.0 7.3 6.5 7.4 2.1 2 1 0 2 2 1 0 Domain of unknown function (DUF4192) BTAD PF03704.17 CRG91636.1 - 6.4 7.2 13.2 5.4 7.4 0.5 3.8 4 0 0 4 4 3 0 Bacterial transcriptional activator domain RRM_1 PF00076.22 CRG91638.1 - 9.7e-30 102.2 0.1 7.9e-18 64.0 0.1 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.18 CRG91638.1 - 3e-12 46.1 0.1 3e-12 46.1 0.1 2.8 4 0 0 4 4 4 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91638.1 - 6.5e-07 29.4 12.6 1.1e-06 28.7 12.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 CRG91638.1 - 0.0049 16.9 6.9 0.0049 16.9 6.9 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit RRM_7 PF16367.5 CRG91638.1 - 0.0084 16.2 0.1 9.7 6.4 0.0 3.1 2 0 0 2 2 2 2 RNA recognition motif DUF515 PF04415.12 CRG91638.1 - 0.031 12.7 0.1 0.06 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Spt20 PF12090.8 CRG91638.1 - 0.16 11.5 15.7 0.011 15.4 10.4 1.7 2 0 0 2 2 2 0 Spt20 family NinF PF05810.12 CRG91638.1 - 0.25 11.3 1.5 0.91 9.4 1.5 1.9 1 0 0 1 1 1 0 NinF protein Syntaxin-18_N PF10496.9 CRG91638.1 - 0.4 11.0 5.8 0.5 10.6 0.1 2.6 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus DUF4834 PF16118.5 CRG91638.1 - 1.1 10.2 3.6 5.4 8.0 3.6 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Piwi PF02171.17 CRG91639.1 - 2.8e-73 246.8 0.0 7.1e-73 245.5 0.0 1.7 2 0 0 2 2 2 1 Piwi domain ArgoN PF16486.5 CRG91639.1 - 3.6e-19 69.7 0.1 7.3e-19 68.7 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 CRG91639.1 - 1.1e-11 44.2 0.0 3e-11 42.8 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 CRG91639.1 - 2.3e-08 33.9 0.0 1.3e-07 31.5 0.0 2.0 2 0 0 2 2 2 1 PAZ domain ArgoL2 PF16488.5 CRG91639.1 - 7.2e-05 23.1 0.2 0.00038 20.7 0.0 2.4 3 0 0 3 3 3 1 Argonaute linker 2 domain T2SSC PF11356.8 CRG91640.1 - 0.5 10.3 3.4 19 5.2 0.1 2.6 2 0 0 2 2 2 0 Type II secretion system protein C SHS2_Rpb7-N PF03876.17 CRG91641.1 - 3.1e-16 59.5 0.1 6.4e-16 58.5 0.0 1.5 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 CRG91641.1 - 3.2e-09 37.0 0.0 5e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 S1 RNA binding domain DUF962 PF06127.11 CRG91642.1 - 5.1e-22 77.8 0.0 1.3e-21 76.5 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) ATP-synt_ab PF00006.25 CRG91643.1 - 4.5e-72 242.2 0.0 6.4e-72 241.6 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 CRG91643.1 - 1.8e-48 164.0 0.1 3e-48 163.3 0.1 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 CRG91643.1 - 1e-14 54.8 3.3 3e-14 53.3 3.3 1.9 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain THF_DHG_CYH PF00763.23 CRG91644.1 - 1.4e-25 89.8 0.1 2e-25 89.3 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 CRG91644.1 - 3e-12 46.2 0.0 1.8e-09 37.1 0.0 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain SPC25 PF06703.11 CRG91645.1 - 8.2e-48 162.2 0.1 9.6e-48 162.0 0.1 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) TCL1_MTCP1 PF01840.17 CRG91645.1 - 0.08 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 TCL1/MTCP1 family EMC3_TMCO1 PF01956.16 CRG91646.1 - 1.7e-53 180.8 0.4 2.3e-53 180.4 0.4 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like Fasciclin PF02469.22 CRG91647.1 - 0.00019 21.7 0.0 0.00034 20.8 0.0 1.4 1 1 0 1 1 1 1 Fasciclin domain MMS19_C PF12460.8 CRG91648.1 - 4.7e-125 418.0 12.8 1.2e-123 413.4 4.6 4.1 3 1 0 4 4 4 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 CRG91648.1 - 9.9e-95 317.0 0.7 1.5e-92 309.9 0.0 3.6 3 0 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 CRG91648.1 - 5.5e-05 23.1 8.6 0.4 11.1 0.0 6.6 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 CRG91648.1 - 0.00053 20.3 10.7 0.84 10.1 0.2 6.3 6 0 0 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 CRG91648.1 - 0.0033 17.9 17.2 1.1 9.8 0.1 6.6 6 0 0 6 6 6 2 HEAT-like repeat Arm PF00514.23 CRG91648.1 - 0.1 12.6 5.4 2.9 8.0 0.1 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 CRG91648.1 - 0.47 10.5 9.9 3.4 7.7 0.1 5.5 6 2 1 7 7 7 0 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.12 CRG91648.1 - 0.5 10.0 2.7 4 7.1 0.1 3.4 4 0 0 4 4 4 0 NUC173 domain SesA PF17107.5 CRG91648.1 - 2.9 8.1 5.1 2.5 8.3 0.1 3.6 4 0 0 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF3106 PF11304.8 CRG91649.1 - 0.29 11.6 2.4 0.61 10.6 1.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) TolA_bind_tri PF16331.5 CRG91650.1 - 0.015 15.3 20.3 0.017 15.2 2.2 3.2 3 0 0 3 3 3 0 TolA binding protein trimerisation SHE3 PF17078.5 CRG91650.1 - 0.016 14.9 34.1 0.46 10.2 24.4 2.3 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 ZapB PF06005.12 CRG91650.1 - 0.048 14.1 2.3 0.048 14.1 2.3 4.7 2 1 1 3 3 3 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 CRG91650.1 - 1.9 8.7 38.8 1e+02 3.1 27.1 3.5 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 CRG91650.1 - 2.4 8.2 39.4 0.31 11.1 11.6 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Lebercilin PF15619.6 CRG91650.1 - 8.5 6.0 43.6 17 5.0 0.9 3.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TMPIT PF07851.13 CRG91650.1 - 9.5 5.4 27.5 1.3 8.2 14.4 2.1 2 0 0 2 2 2 0 TMPIT-like protein HIP1_clath_bdg PF16515.5 CRG91650.1 - 9.8 6.9 33.1 1 10.0 11.9 3.5 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 GPI-anchored PF10342.9 CRG91651.1 - 3.8e-14 53.2 0.3 3.8e-14 53.2 0.3 2.2 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Big_2 PF02368.18 CRG91651.1 - 0.1 12.5 6.2 2.1 8.3 0.4 2.9 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 2) SGT1 PF07093.11 CRG91651.1 - 0.22 9.9 0.4 0.26 9.7 0.4 1.1 1 0 0 1 1 1 0 SGT1 protein BUD22 PF09073.10 CRG91651.1 - 1.8 7.8 8.0 2.2 7.6 8.0 1.1 1 0 0 1 1 1 0 BUD22 YL1 PF05764.13 CRG91651.1 - 3.9 7.5 7.1 5.6 7.0 7.1 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CBF PF03914.17 CRG91652.1 - 3.1e-38 131.5 0.5 6.3e-38 130.5 0.5 1.5 1 0 0 1 1 1 1 CBF/Mak21 family PerC PF06069.11 CRG91652.1 - 0.17 12.1 0.0 0.41 10.9 0.0 1.6 1 0 0 1 1 1 0 PerC transcriptional activator Mt_ATP-synt_B PF05405.14 CRG91653.1 - 1.4e-52 177.6 6.2 1.9e-52 177.2 6.2 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF1539 PF07560.11 CRG91653.1 - 0.041 14.0 0.5 0.094 12.8 0.5 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) rve_3 PF13683.6 CRG91653.1 - 0.14 11.9 0.5 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Integrase core domain Sel1 PF08238.12 CRG91654.1 - 1.4e-16 60.6 0.6 6.5e-07 29.8 0.0 3.6 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.6 CRG91654.1 - 0.0067 17.0 0.4 1.8 9.4 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat RCC1 PF00415.18 CRG91655.1 - 3.2e-52 175.0 0.1 3.4e-11 43.6 0.0 7.4 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 CRG91655.1 - 7.1e-39 130.8 23.1 3e-08 33.3 0.4 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Dicty_REP PF05086.12 CRG91655.1 - 0.18 9.8 4.8 0.21 9.5 4.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 CRG91655.1 - 2.8 6.6 7.0 4 6.1 7.0 1.2 1 0 0 1 1 1 0 Presenilin bZIP_1 PF00170.21 CRG91656.1 - 6.3e-07 29.4 14.1 6.3e-07 29.4 14.1 2.5 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 CRG91656.1 - 8e-06 25.9 8.3 8e-06 25.9 8.3 3.0 2 1 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 CRG91656.1 - 7.5e-05 23.2 13.9 7.5e-05 23.2 13.9 4.4 2 1 2 4 4 4 1 bZIP Maf transcription factor TMF_DNA_bd PF12329.8 CRG91656.1 - 0.012 15.6 3.3 0.012 15.6 3.3 3.3 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1062 PF06353.12 CRG91656.1 - 5.2 7.9 9.0 9.2 7.1 4.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1062) zf_CCCH_4 PF18345.1 CRG91657.1 - 2.5e-09 36.9 26.9 0.12 12.5 0.7 6.2 5 1 0 5 5 5 5 Zinc finger domain zf-CCCH PF00642.24 CRG91657.1 - 1.9e-08 34.0 27.6 0.0077 16.1 0.2 5.3 5 0 0 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 CRG91657.1 - 3.8e-06 27.1 13.6 0.00034 20.8 1.8 3.7 2 2 1 3 3 3 3 Zinc-finger containing family zf-CCCH_4 PF18044.1 CRG91657.1 - 0.0058 16.4 0.1 0.0058 16.4 0.1 5.2 5 1 0 5 5 5 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 CRG91657.1 - 0.058 13.9 2.5 0.058 13.9 2.5 5.1 5 0 0 5 5 5 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 CRG91657.1 - 0.059 14.1 26.4 0.86 10.3 0.6 5.5 2 1 3 5 5 5 0 Torus domain zf-C3H1 PF10650.9 CRG91657.1 - 0.12 12.1 0.0 0.12 12.1 0.0 4.9 5 0 0 5 5 5 0 Putative zinc-finger domain TFIIF_beta_N PF17683.1 CRG91658.1 - 1.6e-32 113.0 1.2 2.7e-32 112.3 1.2 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 CRG91658.1 - 3.9e-25 87.8 0.3 8.3e-25 86.7 0.3 1.6 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 CRG91658.1 - 0.0037 18.1 1.8 0.016 16.0 1.8 2.0 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain PCI PF01399.27 CRG91659.1 - 7.5e-13 48.9 0.0 1.9e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 CRG91659.1 - 0.00021 21.1 0.1 0.00038 20.2 0.1 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 Herpes_UL14 PF03580.14 CRG91659.1 - 0.024 14.9 1.0 4.5 7.5 0.1 2.4 1 1 1 2 2 2 0 Herpesvirus UL14-like protein TPR_19 PF14559.6 CRG91659.1 - 0.63 10.6 8.3 10 6.7 0.0 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat FAD_binding_2 PF00890.24 CRG91660.1 - 5.4e-85 286.0 0.2 7.1e-85 285.6 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 CRG91660.1 - 1.1e-21 76.7 0.1 1e-19 70.5 0.0 3.2 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 CRG91660.1 - 6.4e-14 52.3 0.5 1.5e-13 51.0 0.5 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 CRG91660.1 - 8.4e-10 38.6 1.0 2.5e-09 37.0 1.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91660.1 - 2.1e-08 34.3 1.2 1.7e-07 31.3 0.2 2.9 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG91660.1 - 2.1e-08 33.8 0.3 2.6e-07 30.2 0.2 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91660.1 - 1.3e-07 30.7 2.7 1.8e-05 23.7 1.2 3.0 2 1 0 2 2 2 1 HI0933-like protein Pyr_redox_3 PF13738.6 CRG91660.1 - 1.8e-06 27.5 0.0 0.02 14.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG91660.1 - 1.7e-05 24.3 0.1 2.9e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 CRG91660.1 - 0.00016 21.0 0.4 0.03 13.6 0.1 2.3 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 CRG91660.1 - 0.00028 20.1 1.9 0.16 11.0 0.5 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Amino_oxidase PF01593.24 CRG91660.1 - 0.00084 18.7 0.4 1.2 8.3 0.0 3.0 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 CRG91660.1 - 0.013 16.1 1.9 4.9 7.8 0.2 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG91660.1 - 0.017 15.1 2.4 0.44 10.5 2.4 2.6 1 1 0 1 1 1 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 CRG91660.1 - 0.059 12.7 0.3 0.11 11.7 0.3 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Macoilin PF09726.9 CRG91661.1 - 4.3 5.8 11.5 6.6 5.2 11.5 1.2 1 0 0 1 1 1 0 Macoilin family DUF3328 PF11807.8 CRG91662.1 - 1.1e-40 139.8 0.9 1.3e-40 139.5 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) REGB_T4 PF10715.9 CRG91662.1 - 0.07 13.4 0.1 0.11 12.7 0.1 1.2 1 0 0 1 1 1 0 T4-page Endoribonuclease RegB DUF3328 PF11807.8 CRG91663.1 - 5.1e-41 140.8 0.1 6e-41 140.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 CRG91664.1 - 2.2e-23 83.2 0.5 2.6e-23 82.9 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) MFS_1 PF07690.16 CRG91665.1 - 3e-33 115.2 39.0 4.5e-29 101.5 18.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sin3a_C PF16879.5 CRG91666.1 - 3e-79 266.7 5.3 1.1e-78 264.9 5.3 2.1 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein Tubulin PF00091.25 CRG91666.1 - 5.1e-67 225.9 0.0 2.4e-66 223.7 0.0 2.2 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain ABC_tran PF00005.27 CRG91666.1 - 1.3e-50 171.5 0.0 8.6e-31 107.3 0.0 3.0 2 0 0 2 2 2 2 ABC transporter PAH PF02671.21 CRG91666.1 - 2.6e-44 149.1 4.8 2.3e-17 62.9 3.1 4.1 3 0 0 3 3 3 3 Paired amphipathic helix repeat Tubulin_C PF03953.17 CRG91666.1 - 3.6e-39 133.8 0.4 7.6e-39 132.8 0.4 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Sin3_corepress PF08295.12 CRG91666.1 - 4.2e-39 132.6 0.1 1.2e-38 131.1 0.1 1.9 1 0 0 1 1 1 1 Sin3 family co-repressor ABC_membrane PF00664.23 CRG91666.1 - 1.7e-37 129.6 17.6 7.7e-23 81.5 11.8 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region 2OG-FeII_Oxy PF03171.20 CRG91666.1 - 3.6e-12 46.6 0.1 1e-11 45.2 0.1 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SMC_N PF02463.19 CRG91666.1 - 1.9e-09 37.3 0.1 0.072 12.5 0.1 4.8 3 2 0 4 4 4 2 RecF/RecN/SMC N terminal domain DIOX_N PF14226.6 CRG91666.1 - 1.9e-08 35.1 0.0 4.9e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal WD40 PF00400.32 CRG91666.1 - 0.00026 21.7 3.7 1.4 9.9 0.3 5.7 7 0 0 7 7 4 1 WD domain, G-beta repeat AAA_16 PF13191.6 CRG91666.1 - 0.0014 19.0 0.6 1.3 9.4 0.1 3.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CRG91666.1 - 0.005 16.4 0.5 0.26 10.9 0.0 3.1 4 0 0 4 4 4 1 AAA domain TSP_NTD PF17804.1 CRG91666.1 - 0.0066 16.7 1.5 0.037 14.3 1.5 2.3 1 0 0 1 1 1 1 Tail specific protease N-terminal domain AAA_22 PF13401.6 CRG91666.1 - 0.0078 16.5 1.3 2.1 8.6 0.0 3.7 2 2 0 2 2 2 1 AAA domain AAA_29 PF13555.6 CRG91666.1 - 0.0087 15.8 0.2 8.1 6.3 0.0 3.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 CRG91666.1 - 0.023 13.8 0.8 0.39 9.7 0.0 2.8 3 0 0 3 3 3 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 CRG91666.1 - 0.024 14.5 0.1 5 7.0 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_21 PF13304.6 CRG91666.1 - 0.03 14.1 5.1 30 4.3 0.0 5.2 4 1 0 5 5 5 0 AAA domain, putative AbiEii toxin, Type IV TA system Tubulin_3 PF14881.6 CRG91666.1 - 0.035 13.8 0.0 0.12 12.0 0.0 1.9 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 CRG91666.1 - 0.038 13.2 0.0 0.081 12.1 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Misat_Tub_SegII PF10644.9 CRG91666.1 - 0.045 14.1 0.6 0.29 11.5 0.0 2.6 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain MMR_HSR1 PF01926.23 CRG91666.1 - 0.048 13.7 0.6 0.34 11.0 0.0 2.7 3 0 0 3 3 2 0 50S ribosome-binding GTPase SbcCD_C PF13558.6 CRG91666.1 - 0.063 13.5 0.0 5.3 7.3 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF2075 PF09848.9 CRG91666.1 - 0.079 12.2 0.5 0.44 9.7 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF87 PF01935.17 CRG91666.1 - 0.13 12.4 3.3 0.68 10.0 0.1 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain DUF3915 PF13054.6 CRG91666.1 - 0.68 9.9 4.4 2.3 8.2 4.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) AcetylCoA_hydro PF02550.15 CRG91667.1 - 1.1e-52 178.9 0.0 1.7e-52 178.3 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 CRG91667.1 - 4.2e-41 140.4 0.0 6.2e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain bZIP_1 PF00170.21 CRG91668.1 - 0.00099 19.2 1.9 0.0022 18.0 1.9 1.5 1 0 0 1 1 1 1 bZIP transcription factor Ribosomal_L20 PF00453.18 CRG91668.1 - 0.04 14.0 0.1 0.13 12.4 0.1 1.9 1 0 0 1 1 1 0 Ribosomal protein L20 Glyco_hydro_17 PF00332.18 CRG91669.1 - 0.00055 19.6 0.2 0.0075 15.9 0.1 2.1 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 Glyco_hydro_72 PF03198.14 CRG91670.1 - 3.9e-124 414.0 7.5 5.3e-124 413.6 7.5 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 CRG91670.1 - 1.2e-18 67.5 2.5 1.2e-18 67.5 2.5 1.9 2 0 0 2 2 2 1 X8 domain Sel1 PF08238.12 CRG91671.1 - 5e-30 103.3 25.4 0.00024 21.7 0.0 7.4 7 0 0 7 7 7 7 Sel1 repeat Chitin_synth_2 PF03142.15 CRG91673.1 - 2.9e-293 973.3 0.1 4.2e-293 972.7 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Acetyltransf_3 PF13302.7 CRG91673.1 - 2.9e-29 102.5 0.0 9.9e-29 100.8 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Glyco_trans_2_3 PF13632.6 CRG91673.1 - 9.1e-14 51.8 1.9 7.4e-13 48.8 1.5 2.8 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 CRG91673.1 - 1.2e-11 45.0 0.0 1.3e-10 41.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 CRG91673.1 - 6.9e-05 22.7 0.0 0.033 14.0 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CRG91673.1 - 0.00037 20.0 0.1 0.0075 15.8 0.0 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Cyt-b5 PF00173.28 CRG91673.1 - 0.028 14.6 0.2 1.8 8.8 0.1 2.7 2 1 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain ECH_1 PF00378.20 CRG91673.1 - 0.088 12.1 0.0 1.7 7.9 0.0 2.2 2 0 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Acetyltransf_1 PF00583.25 CRG91673.1 - 0.18 12.0 0.0 0.59 10.4 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) family Ank_2 PF12796.7 CRG91674.1 - 9.1e-06 26.2 1.0 0.00077 20.0 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) WD40 PF00400.32 CRG91674.1 - 0.00028 21.6 1.7 0.0047 17.7 0.1 3.4 3 0 0 3 3 3 1 WD domain, G-beta repeat Ank_4 PF13637.6 CRG91674.1 - 0.00068 20.2 0.1 0.029 14.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG91674.1 - 0.032 14.7 0.0 8.6 7.3 0.0 3.8 4 0 0 4 4 4 0 Ankyrin repeat Ank_5 PF13857.6 CRG91674.1 - 0.044 14.1 0.2 5.7 7.4 0.0 3.0 2 1 0 2 2 2 0 Ankyrin repeats (many copies) Ank PF00023.30 CRG91674.1 - 0.073 13.6 0.4 3.8 8.1 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat 2-Hacid_dh_C PF02826.19 CRG91675.1 - 7.9e-34 116.6 0.0 5.9e-24 84.4 0.0 2.4 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DHDPS PF00701.22 CRG91675.1 - 7.6e-29 100.3 0.0 3.7e-28 98.1 0.0 1.8 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family TPR_12 PF13424.6 CRG91676.1 - 4.6e-10 39.7 6.9 0.00013 22.2 0.7 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG91676.1 - 9.7e-06 25.4 4.5 0.25 11.6 0.1 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG91676.1 - 7.9e-05 22.2 1.2 0.0022 17.4 0.3 2.4 1 1 1 2 2 2 1 MalT-like TPR region TPR_1 PF00515.28 CRG91676.1 - 0.0064 16.3 3.1 8.1 6.5 0.4 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG91676.1 - 0.021 14.9 9.4 5.3 7.4 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 CRG91676.1 - 0.062 13.2 5.9 2.9 7.9 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat DHHC PF01529.20 CRG91677.1 - 6.4e-19 68.4 2.0 8.9e-19 67.9 2.0 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase HATPase_c_3 PF13589.6 CRG91678.1 - 9.9e-13 48.1 0.2 2.2e-12 47.0 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 CRG91678.1 - 8.6e-08 32.7 0.0 2.1e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 CRG91678.1 - 9.6e-08 31.7 0.0 2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain DUF202 PF02656.15 CRG91679.1 - 4.1e-14 52.8 2.8 4.1e-14 52.8 2.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) NMN_transporter PF04973.12 CRG91679.1 - 0.29 11.1 4.5 0.42 10.6 4.5 1.1 1 0 0 1 1 1 0 Nicotinamide mononucleotide transporter Myc_N PF01056.18 CRG91679.1 - 1.3 8.8 4.3 1.6 8.5 4.3 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Pkinase PF00069.25 CRG91680.1 - 1.3e-67 228.0 0.0 1.8e-67 227.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91680.1 - 1.1e-43 149.4 0.0 1.7e-43 148.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 CRG91680.1 - 2.1e-07 31.0 0.1 0.028 14.6 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 CRG91680.1 - 6.5e-06 25.7 0.0 1.1e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CRG91680.1 - 0.076 12.4 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family OPA3 PF07047.12 CRG91681.1 - 6e-51 171.4 2.2 6e-51 171.4 2.2 1.6 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) Med11 PF10280.9 CRG91681.1 - 0.0017 18.8 1.1 0.0017 18.8 1.1 2.3 2 1 0 2 2 2 1 Mediator complex protein DUF4472 PF14739.6 CRG91681.1 - 0.48 11.2 10.2 0.38 11.5 0.9 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4472) IucA_IucC PF04183.12 CRG91682.1 - 5.5e-17 62.1 0.1 9.9e-13 48.2 0.0 2.3 2 0 0 2 2 2 2 IucA / IucC family FhuF PF06276.12 CRG91682.1 - 2.3e-12 47.6 0.0 4.4e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter TTL PF03133.15 CRG91682.1 - 0.16 11.0 0.0 0.39 9.8 0.0 1.5 2 0 0 2 2 2 0 Tubulin-tyrosine ligase family Cys_Met_Meta_PP PF01053.20 CRG91683.1 - 1.2e-25 89.9 0.0 2e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme AraC_binding PF02311.19 CRG91683.1 - 0.15 11.9 0.0 3 7.8 0.0 2.6 3 0 0 3 3 3 0 AraC-like ligand binding domain TauD PF02668.16 CRG91684.1 - 2.6e-45 155.3 0.2 4.7e-45 154.5 0.2 1.4 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ChaB PF06150.12 CRG91684.1 - 0.063 13.9 0.2 0.13 12.9 0.2 1.4 1 0 0 1 1 1 0 ChaB F-box-like PF12937.7 CRG91685.1 - 1.8e-05 24.5 0.2 5.2e-05 23.1 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 CRG91685.1 - 0.047 13.6 2.7 0.082 12.8 0.3 2.4 2 0 0 2 2 2 0 F-box domain Cupin_1 PF00190.22 CRG91686.1 - 1.8e-25 89.3 0.0 5.7e-17 61.7 0.0 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 CRG91686.1 - 2.2e-14 52.9 0.2 4.3e-10 39.1 0.0 2.3 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 CRG91686.1 - 9.9e-06 25.2 0.2 0.019 14.6 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 CRG91686.1 - 0.003 17.4 0.0 0.0049 16.8 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase SKG6 PF08693.10 CRG91687.1 - 3.1e-07 29.7 3.0 5.4e-07 28.9 3.0 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain GPI-anchored PF10342.9 CRG91687.1 - 0.00024 21.8 1.1 0.00053 20.7 0.0 2.1 1 1 1 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family VSP PF03302.13 CRG91687.1 - 0.0014 17.5 0.1 0.0019 17.2 0.1 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein TMEM154 PF15102.6 CRG91687.1 - 0.014 15.3 2.0 0.025 14.5 0.7 2.0 1 1 1 2 2 2 0 TMEM154 protein family DUF4448 PF14610.6 CRG91687.1 - 0.015 15.1 0.0 0.027 14.2 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) DUF5385 PF17359.2 CRG91687.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) MLANA PF14991.6 CRG91687.1 - 0.14 12.4 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A Abhydro_lipase PF04083.16 CRG91688.1 - 9.9e-20 69.9 0.2 3.7e-19 68.1 0.0 2.0 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 CRG91688.1 - 1.6e-05 24.7 0.1 7.5e-05 22.5 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG91688.1 - 0.025 13.8 0.0 0.052 12.8 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ank_2 PF12796.7 CRG91689.1 - 1e-94 311.3 0.0 8.6e-15 55.1 0.0 6.4 1 1 7 8 8 8 8 Ankyrin repeats (3 copies) Ank PF00023.30 CRG91689.1 - 1e-57 190.2 0.0 1.9e-06 28.0 0.1 11.1 11 0 0 11 11 11 10 Ankyrin repeat Ank_3 PF13606.6 CRG91689.1 - 1.1e-55 179.0 0.0 1.9e-05 24.7 0.0 12.5 12 0 0 12 12 12 10 Ankyrin repeat Ank_5 PF13857.6 CRG91689.1 - 4.3e-46 154.4 1.3 1.4e-10 41.2 0.0 7.8 2 1 3 7 7 7 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 CRG91689.1 - 6.5e-44 147.8 0.0 1.6e-08 35.0 0.1 8.6 3 1 5 8 8 8 8 Ankyrin repeats (many copies) PNP_UDP_1 PF01048.20 CRG91689.1 - 3.4e-11 42.9 0.0 7.1e-11 41.8 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily NACHT PF05729.12 CRG91689.1 - 0.017 15.1 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain p450 PF00067.22 CRG91690.1 - 6.2e-43 147.2 0.0 9.1e-43 146.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Melibiase_2 PF16499.5 CRG91690.1 - 1.4e-07 30.9 0.2 3.3e-06 26.5 0.0 2.5 2 1 0 2 2 2 1 Alpha galactosidase A Melibiase PF02065.18 CRG91690.1 - 0.00014 21.0 0.0 0.00022 20.3 0.0 1.2 1 0 0 1 1 1 1 Melibiase Glyco_hydro_31 PF01055.26 CRG91690.1 - 0.00065 19.0 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Ferrochelatase PF00762.19 CRG91690.1 - 0.053 12.6 0.0 6.8 5.7 0.0 2.4 2 0 0 2 2 2 0 Ferrochelatase Methyltransf_23 PF13489.6 CRG91691.1 - 3.4e-23 82.3 0.0 5.8e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG91691.1 - 5.9e-10 39.7 0.0 2.3e-09 37.8 0.0 2.1 2 1 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG91691.1 - 3.8e-07 30.7 0.0 8.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91691.1 - 1.9e-06 27.7 0.0 0.058 13.2 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CRG91691.1 - 5.5e-05 23.8 0.0 0.00067 20.4 0.0 2.5 2 1 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 CRG91691.1 - 0.0075 15.8 0.0 0.04 13.5 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 CRG91691.1 - 0.011 15.3 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase FtsJ PF01728.19 CRG91691.1 - 0.018 15.2 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase CMAS PF02353.20 CRG91691.1 - 0.038 13.3 0.0 0.1 11.8 0.0 1.6 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 CRG91691.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 CRG91691.1 - 0.19 11.0 0.0 0.55 9.5 0.0 1.6 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Phosphoesterase PF04185.14 CRG91692.1 - 3.4e-61 207.4 1.0 9e-61 206.0 1.0 1.7 1 1 0 1 1 1 1 Phosphoesterase family Sugar_tr PF00083.24 CRG91693.1 - 6.8e-126 420.8 27.4 7.9e-126 420.5 27.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91693.1 - 4.4e-23 81.8 61.1 1.3e-20 73.6 32.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily PIRT PF15099.6 CRG91693.1 - 0.031 13.8 0.4 0.54 9.8 0.0 2.4 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family MSP1b PF03429.13 CRG91693.1 - 0.17 10.0 0.1 0.24 9.4 0.1 1.2 1 0 0 1 1 1 0 Major surface protein 1B Amidase PF01425.21 CRG91694.1 - 2.4e-32 112.5 2.7 1.3e-31 110.1 1.0 2.1 2 0 0 2 2 2 2 Amidase Sulfatase PF00884.23 CRG91695.1 - 4e-18 65.9 0.5 2.5e-17 63.2 0.5 2.0 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 CRG91695.1 - 0.0012 18.5 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 CRG91695.1 - 0.082 11.5 0.0 0.12 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Zn_clus PF00172.18 CRG91697.1 - 7.4e-06 26.0 4.9 1.9e-05 24.7 4.9 1.7 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG91697.1 - 7.7e-05 21.9 0.0 0.00011 21.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Solute_trans_a PF03619.16 CRG91698.1 - 2.1e-15 57.0 3.3 2.7e-15 56.6 3.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Tyrosinase PF00264.20 CRG91699.1 - 5.8e-54 183.7 3.7 5.8e-54 183.7 3.7 1.6 2 0 0 2 2 2 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 CRG91699.1 - 4.5e-25 88.7 0.0 7.2e-25 88.0 0.0 1.3 1 0 0 1 1 1 1 Tyosinase C-terminal domain Metallophos PF00149.28 CRG91700.1 - 2.9e-09 37.7 0.5 5.5e-09 36.8 0.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase eIF-3_zeta PF05091.12 CRG91701.1 - 3e-208 693.0 0.0 3.7e-208 692.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) bZIP_1 PF00170.21 CRG91702.1 - 0.05 13.7 13.8 0.25 11.4 13.9 2.0 1 1 0 1 1 1 0 bZIP transcription factor DUF3349 PF11829.8 CRG91702.1 - 0.17 12.7 2.3 0.97 10.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) DUF3340 PF11818.8 CRG91702.1 - 0.39 10.9 5.0 0.82 9.8 5.0 1.5 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) bZIP_2 PF07716.15 CRG91702.1 - 0.95 9.6 16.7 4.1 7.6 5.3 2.4 2 0 0 2 2 2 0 Basic region leucine zipper TEX13 PF15186.6 CRG91702.1 - 5 6.8 9.7 7.4 6.2 9.7 1.2 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family PTP_N PF12453.8 CRG91703.1 - 0.21 11.3 0.7 21 4.9 0.1 2.8 2 0 0 2 2 2 0 Protein tyrosine phosphatase N terminal DUF3546 PF12066.8 CRG91704.1 - 9.8e-31 106.2 1.7 9.8e-31 106.2 1.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 CRG91704.1 - 3e-13 50.6 0.9 8.6e-13 49.1 0.9 1.9 1 0 0 1 1 1 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 CRG91704.1 - 9.3e-12 44.5 0.1 2.2e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) CBFB_NFYA PF02045.15 CRG91705.1 - 1.6e-28 99.1 4.6 3e-28 98.2 4.6 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.12 CRG91705.1 - 0.047 12.8 0.0 0.077 12.1 0.0 1.2 1 0 0 1 1 1 0 Hus1-like protein Lipase_3 PF01764.25 CRG91706.1 - 1.1e-33 116.0 0.0 1.5e-33 115.6 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 CRG91706.1 - 2.4e-05 24.1 0.0 3.9e-05 23.4 0.0 1.4 2 0 0 2 2 2 1 Putative esterase PGAP1 PF07819.13 CRG91706.1 - 0.00072 19.3 0.0 0.0023 17.7 0.0 1.8 2 1 0 2 2 2 1 PGAP1-like protein DUF2974 PF11187.8 CRG91706.1 - 0.0017 18.0 0.3 0.026 14.1 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 CRG91706.1 - 0.0018 17.6 0.0 0.0027 17.0 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG91706.1 - 0.005 17.5 0.0 0.0063 17.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Cutinase PF01083.22 CRG91706.1 - 0.027 14.4 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Cutinase Thioesterase PF00975.20 CRG91706.1 - 0.055 13.6 0.1 0.11 12.6 0.0 1.5 1 1 0 1 1 1 0 Thioesterase domain DUF676 PF05057.14 CRG91706.1 - 0.22 11.0 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) FAD_binding_3 PF01494.19 CRG91707.1 - 9.4e-07 28.4 0.1 1.2e-06 28.1 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain DUF4188 PF13826.6 CRG91708.1 - 1.7e-30 105.8 0.1 2.4e-30 105.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) WD40 PF00400.32 CRG91709.1 - 1.1e-52 174.9 17.6 3.8e-08 33.9 0.2 8.6 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG91709.1 - 9.4e-14 51.5 0.1 0.00024 21.3 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG91709.1 - 9.6e-09 34.4 0.5 0.01 14.5 0.0 3.5 3 0 0 3 3 3 3 Nucleoporin Nup120/160 Cast PF10174.9 CRG91709.1 - 0.03 12.6 0.7 0.04 12.2 0.7 1.1 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Nucleoporin_N PF08801.11 CRG91709.1 - 0.054 12.2 0.0 6.4 5.4 0.0 3.0 2 1 1 3 3 3 0 Nup133 N terminal like Pox_A_type_inc PF04508.12 CRG91709.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat bZIP_1 PF00170.21 CRG91709.1 - 0.2 11.8 2.0 0.21 11.7 0.5 1.7 2 0 0 2 2 2 0 bZIP transcription factor Kinesin PF00225.23 CRG91710.1 - 1.4e-107 359.5 0.0 2.6e-107 358.6 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 CRG91710.1 - 3.5e-43 147.9 0.0 8.9e-43 146.6 0.0 1.8 1 0 0 1 1 1 1 Kinesin protein Kinesin_assoc PF16183.5 CRG91710.1 - 1e-38 133.3 7.7 1.1e-31 110.4 0.2 3.1 2 1 1 3 3 3 2 Kinesin-associated Microtub_bd PF16796.5 CRG91710.1 - 1.3e-21 77.1 0.0 4.1e-21 75.5 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 CRG91710.1 - 1.7e-07 31.7 0.0 5.9e-07 30.0 0.0 1.9 1 0 0 1 1 1 1 PH domain FHA PF00498.26 CRG91710.1 - 1.1e-05 25.7 0.1 0.00011 22.5 0.1 2.9 2 0 0 2 2 2 1 FHA domain KIF1B PF12423.8 CRG91710.1 - 1.5e-05 25.3 2.6 1.7e-05 25.1 0.1 2.6 2 0 0 2 2 2 1 Kinesin protein 1B Yop-YscD_cpl PF16697.5 CRG91710.1 - 0.0019 18.5 0.0 0.0048 17.2 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain AAA_22 PF13401.6 CRG91710.1 - 0.052 13.8 0.0 0.19 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain Selenoprotein_S PF06936.11 CRG91710.1 - 0.5 10.2 7.4 1.4 8.7 7.4 1.7 1 0 0 1 1 1 0 Selenoprotein S (SelS) Syntaxin-6_N PF09177.11 CRG91710.1 - 1.1 9.8 8.4 4.2 8.0 0.7 3.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal UPF0242 PF06785.11 CRG91710.1 - 2.4 8.2 13.3 5 7.2 0.5 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF87 PF01935.17 CRG91710.1 - 6.5 6.8 8.0 31 4.6 0.3 3.8 4 0 0 4 4 4 0 Helicase HerA, central domain Ank_2 PF12796.7 CRG91711.1 - 5.4e-23 81.4 2.3 4.4e-06 27.2 0.1 5.7 3 1 3 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG91711.1 - 2.7e-22 78.8 2.0 0.0029 18.1 0.0 9.1 6 3 3 9 9 9 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG91711.1 - 3.2e-21 74.8 5.4 0.035 14.6 0.0 9.0 9 0 0 9 9 9 5 Ankyrin repeat Ank_3 PF13606.6 CRG91711.1 - 1.1e-20 71.5 1.4 0.0033 17.8 0.0 8.5 9 0 0 9 9 9 5 Ankyrin repeat Fungal_trans PF04082.18 CRG91711.1 - 6.4e-20 71.3 0.0 1.1e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Ank_5 PF13857.6 CRG91711.1 - 1.7e-15 56.8 7.8 3.3e-05 24.1 0.2 6.2 4 2 1 5 5 5 4 Ankyrin repeats (many copies) F-box-like PF12937.7 CRG91711.1 - 0.0024 17.8 0.1 0.0058 16.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like Zn_clus PF00172.18 CRG91711.1 - 0.054 13.6 0.8 0.12 12.5 0.8 1.6 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_transf_90 PF05686.12 CRG91712.1 - 1.2e-29 103.4 1.9 1.8e-29 102.9 1.9 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 CRG91712.1 - 0.0027 18.1 0.0 0.0067 16.8 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Fascin PF06268.13 CRG91712.1 - 0.12 12.6 0.4 0.34 11.2 0.1 1.9 2 0 0 2 2 2 0 Fascin domain Scaffolding_pro PF11418.8 CRG91712.1 - 0.13 12.9 0.0 3.8 8.1 0.0 2.4 2 0 0 2 2 2 0 Phi29 scaffolding protein DivIC PF04977.15 CRG91712.1 - 0.14 11.9 3.3 1.4 8.8 0.0 2.8 3 0 0 3 3 3 0 Septum formation initiator BCS1_N PF08740.11 CRG91713.1 - 4.7e-47 160.4 0.3 4.7e-47 160.4 0.3 2.0 3 0 0 3 3 3 1 BCS1 N terminal AAA PF00004.29 CRG91713.1 - 1.6e-17 64.1 0.0 2.3e-08 34.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG91713.1 - 6.1e-05 23.5 0.0 0.00014 22.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 CRG91713.1 - 0.0052 16.0 0.0 0.0093 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 CRG91713.1 - 0.018 15.0 0.0 0.044 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CRG91713.1 - 0.11 12.8 0.0 0.75 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 CRG91713.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_18 PF13238.6 CRG91713.1 - 0.13 12.8 0.2 0.65 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 CRG91713.1 - 0.14 11.7 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CRG91713.1 - 0.15 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF3446 PF11928.8 CRG91713.1 - 2.6 8.4 8.8 12 6.3 0.7 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain Vps51 PF08700.11 CRG91714.1 - 0.12 12.4 0.7 2.5 8.2 0.1 2.6 2 0 0 2 2 2 0 Vps51/Vps67 DUF3124 PF11322.8 CRG91714.1 - 0.15 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3124) Imm41 PF15592.6 CRG91714.1 - 0.36 11.2 2.2 2.2 8.6 0.1 2.8 3 0 0 3 3 3 0 Immunity protein 41 Na_H_Exchanger PF00999.21 CRG91715.1 - 2.5e-30 105.5 38.2 5.4e-26 91.3 22.2 3.0 3 0 0 3 3 3 3 Sodium/hydrogen exchanger family DUF4271 PF14093.6 CRG91715.1 - 0.041 13.8 4.8 1.9 8.4 4.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4271) APH PF01636.23 CRG91716.1 - 8e-11 42.3 0.0 1.4e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG91716.1 - 0.0039 16.8 0.0 0.0059 16.2 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 CRG91716.1 - 0.067 12.5 0.0 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Phosphodiest PF01663.22 CRG91717.1 - 1.2e-83 281.6 0.2 1.7e-83 281.2 0.2 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 CRG91717.1 - 0.0015 18.0 0.4 0.15 11.4 0.4 2.4 1 1 0 1 1 1 1 Sulfatase Glyco_hydro_88 PF07470.13 CRG91718.1 - 4.2e-13 49.1 1.2 6.6e-13 48.4 1.2 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Fungal_trans PF04082.18 CRG91719.1 - 6.5e-23 81.1 0.2 9.9e-23 80.5 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91719.1 - 1.4e-07 31.5 14.6 2.5e-07 30.7 14.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Alginate_lyase PF05426.12 CRG91720.1 - 3.2e-16 59.7 0.5 7.1e-16 58.6 0.5 1.5 1 1 0 1 1 1 1 Alginate lyase Alginate_lyase PF05426.12 CRG91721.1 - 1.3e-16 60.9 11.8 2.2e-16 60.2 11.8 1.3 1 0 0 1 1 1 1 Alginate lyase Glyco_hydro_28 PF00295.17 CRG91722.1 - 1.1e-11 44.4 2.3 1.8e-11 43.7 2.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 CRG91722.1 - 2.6e-06 27.4 19.3 9.7e-05 22.3 8.2 2.2 1 1 1 2 2 2 2 Right handed beta helix region MFS_1 PF07690.16 CRG91723.1 - 6.1e-19 68.2 12.1 1.5e-14 53.7 12.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily TM_helix PF05552.12 CRG91723.1 - 0.034 14.1 2.4 2.1 8.4 0.2 3.2 2 0 0 2 2 2 0 Conserved TM helix FAD_binding_3 PF01494.19 CRG91725.1 - 8.4e-91 304.8 0.0 1e-90 304.5 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG91725.1 - 3.4e-11 43.3 0.1 6.8e-05 22.6 0.1 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG91725.1 - 8.3e-06 25.2 0.1 2.5e-05 23.6 0.1 1.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG91725.1 - 0.00013 22.1 0.1 0.00033 20.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CRG91725.1 - 0.00019 20.9 0.0 0.0022 17.4 0.0 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG91725.1 - 0.0022 17.1 0.1 0.006 15.7 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 CRG91725.1 - 0.0071 16.9 0.1 0.26 11.9 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91725.1 - 0.043 12.5 0.1 1.3 7.7 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Amino_oxidase PF01593.24 CRG91725.1 - 0.064 12.5 0.0 0.23 10.7 0.0 1.8 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Fungal_trans PF04082.18 CRG91726.1 - 8e-14 51.3 0.4 1.2e-13 50.7 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91726.1 - 3.2e-09 36.8 10.9 6.3e-09 35.8 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_8 PF13450.6 CRG91727.1 - 1.3e-11 44.6 0.4 2.9e-11 43.4 0.4 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CRG91727.1 - 1.1e-06 28.2 0.4 1.6e-06 27.7 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 CRG91727.1 - 2.1e-06 27.3 0.0 2.8e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 CRG91727.1 - 2.3e-05 23.7 2.2 3.5e-05 23.1 2.2 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CRG91727.1 - 6.5e-05 21.8 0.5 9.6e-05 21.2 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 CRG91727.1 - 9.6e-05 21.7 0.3 0.00014 21.2 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG91727.1 - 0.0017 18.0 0.9 0.022 14.4 2.0 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG91727.1 - 0.0094 15.2 1.3 0.059 12.6 0.5 2.2 2 1 1 3 3 3 1 Thi4 family Pyr_redox PF00070.27 CRG91727.1 - 0.062 13.9 0.2 0.11 13.0 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG91727.1 - 0.08 12.2 0.3 0.12 11.6 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Lycopene_cycl PF05834.12 CRG91727.1 - 0.093 11.8 0.1 0.14 11.2 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 CRG91727.1 - 0.11 13.0 0.0 0.82 10.1 0.0 2.1 1 1 0 1 1 1 0 Putative NAD(P)-binding GIDA PF01134.22 CRG91727.1 - 0.22 10.6 0.6 0.34 9.9 0.6 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Ofd1_CTDD PF10637.9 CRG91729.1 - 2.5e-96 322.0 0.0 7e-93 310.7 0.1 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 CRG91729.1 - 3.1e-25 88.7 0.0 7.7e-25 87.4 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 CRG91729.1 - 3.8e-14 53.3 0.0 8.4e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF1963 PF09234.10 CRG91729.1 - 0.09 13.2 1.9 0.19 12.1 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1963) CPSF100_C PF13299.6 CRG91729.1 - 0.29 11.3 3.0 0.38 10.9 0.9 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Cnd2 PF05786.14 CRG91729.1 - 0.37 9.4 9.9 0.56 8.8 9.9 1.2 1 0 0 1 1 1 0 Condensin complex subunit 2 Connexin PF00029.19 CRG91729.1 - 0.41 10.4 0.7 4.2 7.1 0.9 2.0 2 0 0 2 2 2 0 Connexin PTPRCAP PF15713.5 CRG91729.1 - 2.6 8.3 13.9 8.1 6.7 13.9 1.8 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 CRG91729.1 - 6.2 5.0 9.1 9.4 4.4 9.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 CRG91729.1 - 9.3 6.0 13.6 18 5.0 13.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HLH PF00010.26 CRG91730.1 - 2e-14 53.3 1.9 3.6e-14 52.4 0.8 2.1 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain ZapB PF06005.12 CRG91730.1 - 0.043 14.3 0.5 0.087 13.3 0.5 1.4 1 0 0 1 1 1 0 Cell division protein ZapB SlyX PF04102.12 CRG91730.1 - 0.059 14.0 1.2 0.089 13.4 0.2 1.9 2 0 0 2 2 2 0 SlyX FAM76 PF16046.5 CRG91730.1 - 0.83 8.9 3.3 1.4 8.2 3.3 1.3 1 0 0 1 1 1 0 FAM76 protein Fzo_mitofusin PF04799.13 CRG91730.1 - 0.96 9.0 2.7 1.7 8.2 2.7 1.3 1 0 0 1 1 1 0 fzo-like conserved region ADH_N PF08240.12 CRG91731.1 - 1.4e-08 34.6 0.1 2.6e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG91731.1 - 1e-06 28.7 0.0 1.8e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91732.1 - 6.7e-19 67.8 0.1 1.3e-18 66.9 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG91732.1 - 6.1e-13 48.9 0.1 1.3e-12 47.9 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Fungal_trans PF04082.18 CRG91732.1 - 2.6e-07 30.0 0.0 3.6e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_32 PF13679.6 CRG91732.1 - 0.051 13.6 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain adh_short PF00106.25 CRG91732.1 - 0.13 11.7 0.3 0.25 10.7 0.3 1.5 1 0 0 1 1 1 0 short chain dehydrogenase SnoaL PF07366.12 CRG91733.1 - 6e-22 77.8 0.0 7e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 CRG91733.1 - 2.2e-15 57.2 0.1 2.7e-15 56.8 0.1 1.1 1 0 0 1 1 1 1 SnoaL-like domain OPT PF03169.15 CRG91734.1 - 5.3e-126 421.7 43.4 6.1e-126 421.5 43.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein TPPK_C PF12555.8 CRG91734.1 - 4.4 7.4 8.4 7.1 6.8 0.4 3.0 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal CrgA PF06781.12 CRG91734.1 - 4.4 7.4 5.9 0.87 9.7 0.1 2.8 3 0 0 3 3 3 0 Cell division protein CrgA Abhydrolase_2 PF02230.16 CRG91735.1 - 5e-23 82.1 0.0 3.8e-14 53.0 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 CRG91735.1 - 3.3e-05 23.5 0.0 6e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 CRG91735.1 - 0.0009 19.9 0.0 0.0043 17.7 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG91735.1 - 0.12 11.6 0.2 1.1 8.5 0.1 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF3265 PF11665.8 CRG91735.1 - 0.21 11.8 0.4 0.4 10.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3265) Nop14 PF04147.12 CRG91735.1 - 0.25 9.5 1.4 0.27 9.4 1.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4611 PF15387.6 CRG91735.1 - 4.1 7.7 7.9 12 6.2 6.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) ECH_1 PF00378.20 CRG91737.1 - 1.2e-21 77.2 0.0 1.6e-21 76.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG91737.1 - 3.5e-05 23.5 0.0 6e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 CRG91737.1 - 0.0005 20.0 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 CCDC168_N PF15804.5 CRG91738.1 - 6.6 6.5 9.7 11 5.8 0.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 168 TAFII55_N PF04658.13 CRG91739.1 - 2.6e-51 173.5 0.1 5.4e-51 172.5 0.1 1.6 1 0 0 1 1 1 1 TAFII55 protein conserved region DUF3492 PF11997.8 CRG91739.1 - 0.023 14.4 0.3 0.038 13.7 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) Bromo_TP PF07524.13 CRG91740.1 - 6e-09 35.8 0.0 1e-08 35.1 0.0 1.4 1 0 0 1 1 1 1 Bromodomain associated TFIID-31kDa PF02291.15 CRG91740.1 - 0.0043 17.1 0.0 0.0073 16.4 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit BRO1 PF03097.18 CRG91741.1 - 2.5e-05 23.3 0.0 3.6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain FliH PF02108.16 CRG91741.1 - 0.052 13.6 0.0 7.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Flagellar assembly protein FliH STE2 PF02116.15 CRG91741.1 - 0.16 11.2 0.2 0.24 10.7 0.2 1.1 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR NDUFB10 PF10249.9 CRG91742.1 - 0.0025 18.3 0.0 0.0028 18.1 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 DUF3431 PF11913.8 CRG91743.1 - 2.8e-85 285.5 0.9 4.9e-85 284.7 0.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Glyco_transf_34 PF05637.12 CRG91743.1 - 2.7e-64 217.1 0.5 4.4e-64 216.5 0.5 1.3 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Sugar_tr PF00083.24 CRG91744.1 - 6.5e-78 262.6 21.0 7.4e-78 262.4 21.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91744.1 - 8.5e-20 71.0 9.4 8.5e-20 71.0 9.4 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF5373 PF17343.2 CRG91744.1 - 0.35 10.7 6.2 0.7 9.7 6.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5373) BTB PF00651.31 CRG91745.1 - 1.4e-08 34.9 0.0 2.7e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF3342 PF11822.8 CRG91745.1 - 0.092 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Sugar_tr PF00083.24 CRG91746.1 - 1.4e-82 278.0 19.5 1.7e-82 277.7 19.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91746.1 - 4.8e-21 75.1 28.3 1e-19 70.7 15.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 CRG91747.1 - 6.5e-24 84.5 0.1 4.6e-18 65.4 0.1 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91747.1 - 3.3e-14 53.0 0.1 2.4e-13 50.2 0.1 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91747.1 - 7.8e-07 29.2 0.1 1.2e-06 28.6 0.1 1.3 1 0 0 1 1 1 1 KR domain Fungal_trans_2 PF11951.8 CRG91748.1 - 7.1e-16 58.0 5.6 6.5e-15 54.8 5.6 2.0 1 1 0 1 1 1 1 Fungal specific transcription factor domain SbcD_C PF12320.8 CRG91748.1 - 0.13 12.6 0.0 0.43 10.9 0.0 1.9 1 0 0 1 1 1 0 Type 5 capsule protein repressor C-terminal domain Fungal_trans PF04082.18 CRG91749.1 - 1.8e-16 60.0 1.7 2.6e-16 59.5 1.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91749.1 - 3.9e-08 33.3 8.4 8.6e-08 32.2 8.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ABC2_membrane PF01061.24 CRG91750.1 - 3.4e-89 297.8 65.2 3.4e-46 157.3 23.9 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 CRG91750.1 - 6.3e-36 123.9 0.0 9.6e-16 58.5 0.0 3.4 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 CRG91750.1 - 1.2e-35 121.3 5.5 3.7e-31 106.9 0.0 3.8 4 0 0 4 4 4 2 CDR ABC transporter ABC_trans_N PF14510.6 CRG91750.1 - 1.8e-19 70.1 0.0 3.7e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 CRG91750.1 - 3.7e-08 32.9 45.7 4.9e-08 32.5 18.6 3.3 2 2 1 3 3 3 2 ABC-2 family transporter protein AAA_16 PF13191.6 CRG91750.1 - 2e-05 25.0 0.1 0.093 13.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 CRG91750.1 - 3.7e-05 23.4 0.0 0.00033 20.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 CRG91750.1 - 0.00049 20.1 0.0 0.035 14.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 CRG91750.1 - 0.0022 17.9 0.1 1.1 8.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG91750.1 - 0.0066 15.9 0.0 0.31 10.5 0.0 2.5 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG91750.1 - 0.015 15.0 0.4 0.74 9.6 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_33 PF13671.6 CRG91750.1 - 0.016 15.3 0.1 6.3 7.0 0.1 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 CRG91750.1 - 0.023 14.8 0.0 9.1 6.4 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 CRG91750.1 - 0.15 12.6 0.0 1.8 9.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 CRG91750.1 - 0.25 10.9 0.7 5.1 6.7 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 CRG91750.1 - 0.25 11.6 1.7 7.4 6.9 0.1 2.8 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CRG91750.1 - 2.7 7.9 4.3 19 5.1 0.3 2.8 3 0 0 3 3 3 0 NACHT domain MFS_1 PF07690.16 CRG91751.1 - 7.2e-34 117.3 46.3 7.2e-34 117.3 46.3 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily HCV_NS4a PF01006.20 CRG91751.1 - 7.2 6.4 7.6 12 5.7 1.3 3.1 2 0 0 2 2 2 0 Hepatitis C virus non-structural protein NS4a Nbl1_Borealin_N PF10444.9 CRG91752.1 - 3.2e-19 68.3 3.4 7.4e-19 67.2 3.4 1.7 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal VWA_2 PF13519.6 CRG91753.1 - 1.1e-20 74.3 0.0 4.5e-20 72.3 0.0 2.0 2 0 0 2 2 2 1 von Willebrand factor type A domain Ssl1 PF04056.14 CRG91753.1 - 2.4e-05 24.2 0.0 3.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 CRG91753.1 - 0.00025 21.3 0.1 0.00036 20.8 0.1 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 CRG91753.1 - 0.039 13.9 0.1 0.11 12.4 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Sybindin PF04099.12 CRG91754.1 - 4.5e-48 162.8 0.0 7.1e-48 162.2 0.0 1.3 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 CRG91754.1 - 8.2e-07 29.2 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region zf-C2H2 PF00096.26 CRG91755.1 - 0.00052 20.3 14.3 0.38 11.3 0.2 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG91755.1 - 0.027 15.3 12.9 0.48 11.4 1.7 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-met PF12874.7 CRG91755.1 - 0.054 13.9 6.0 2.1 8.9 1.9 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 CRG91755.1 - 0.28 11.5 5.4 0.45 10.9 2.4 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.5 CRG91755.1 - 0.74 10.2 4.7 7.9 6.9 0.2 2.6 1 1 0 2 2 2 0 C2H2-type zinc ribbon FOXP-CC PF16159.5 CRG91755.1 - 1.1 10.0 6.1 1.1 10.0 0.1 2.7 2 1 1 3 3 3 0 FOXP coiled-coil domain BIR PF00653.21 CRG91755.1 - 1.1 9.9 7.4 0.15 12.8 2.9 1.9 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain RhoGAP PF00620.27 CRG91756.1 - 6.6e-35 120.2 0.2 1.4e-34 119.1 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 CRG91756.1 - 1.7e-29 101.8 34.1 1.1e-11 44.8 5.7 4.8 5 0 0 5 5 5 4 LIM domain Desulfoferrod_N PF06397.12 CRG91756.1 - 0.29 10.8 1.7 0.38 10.4 0.2 2.1 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-UDP PF14569.6 CRG91756.1 - 2.7 8.2 5.2 0.58 10.3 0.8 2.3 2 0 0 2 2 2 0 Zinc-binding RING-finger 3Beta_HSD PF01073.19 CRG91757.1 - 1.1e-44 152.5 0.0 4.5e-44 150.5 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family UQ_con PF00179.26 CRG91757.1 - 1.1e-40 138.5 0.0 4.5e-29 100.9 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Epimerase PF01370.21 CRG91757.1 - 3.5e-16 59.4 0.1 3.7e-15 56.0 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 CRG91757.1 - 9.7e-11 41.3 0.0 7.8e-10 38.4 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 CRG91757.1 - 4.5e-09 36.2 0.1 7.4e-07 28.9 0.1 3.1 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Prok-E2_B PF14461.6 CRG91757.1 - 8.7e-08 31.9 0.0 0.00039 20.1 0.0 2.6 2 1 0 2 2 2 2 Prokaryotic E2 family B RmlD_sub_bind PF04321.17 CRG91757.1 - 0.0019 17.4 0.0 0.0073 15.4 0.0 1.9 1 1 0 1 1 1 1 RmlD substrate binding domain UEV PF05743.13 CRG91757.1 - 0.016 15.1 0.0 0.14 12.0 0.0 2.3 2 0 0 2 2 2 0 UEV domain DUF2119 PF09892.9 CRG91757.1 - 0.091 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) RWD PF05773.22 CRG91757.1 - 0.11 12.7 0.0 1.5 9.2 0.0 2.4 2 0 0 2 2 2 0 RWD domain Pkinase PF00069.25 CRG91758.1 - 6.6e-58 196.1 0.0 2.5e-37 128.7 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91758.1 - 1.4e-27 96.6 0.0 9.3e-20 71.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 CRG91758.1 - 1.5e-12 47.7 0.0 2.8e-12 46.8 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 CRG91758.1 - 1.4e-06 27.8 0.6 0.00057 19.3 0.0 3.1 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 CRG91758.1 - 4.9e-05 23.4 0.3 0.006 16.5 0.7 2.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family PAS_9 PF13426.7 CRG91758.1 - 0.0066 16.7 0.0 0.02 15.1 0.0 1.8 1 0 0 1 1 1 1 PAS domain Haspin_kinase PF12330.8 CRG91758.1 - 0.024 13.6 0.2 0.047 12.6 0.2 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 CRG91758.1 - 0.11 11.6 0.2 0.18 10.8 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PAS_4 PF08448.10 CRG91758.1 - 0.14 12.4 0.1 0.67 10.2 0.0 2.2 2 0 0 2 2 2 0 PAS fold Kdo PF06293.14 CRG91758.1 - 0.17 11.2 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CRG91758.1 - 1.8 7.3 3.8 1.6 7.5 0.1 2.6 2 0 0 2 2 2 0 Fungal protein kinase CorA PF01544.18 CRG91759.1 - 6.2e-07 29.0 0.2 1.3e-06 28.0 0.2 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MS_channel PF00924.18 CRG91760.1 - 1.3e-23 83.7 1.2 2.5e-23 82.7 1.2 1.5 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_5 PF13202.6 CRG91760.1 - 0.00028 20.2 0.0 0.00069 19.0 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 CRG91760.1 - 0.0011 18.4 0.3 0.0024 17.3 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 CRG91760.1 - 0.0011 18.7 0.0 0.0034 17.2 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 CRG91760.1 - 0.028 14.9 0.2 0.065 13.7 0.2 1.6 1 0 0 1 1 1 0 EF-hand domain pair Tubulin PF00091.25 CRG91761.1 - 3.4e-64 216.7 0.0 4.6e-64 216.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 CRG91761.1 - 7.7e-44 148.9 0.0 1.2e-43 148.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 CRG91761.1 - 0.0004 20.1 0.0 0.00089 19.0 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Mito_carr PF00153.27 CRG91762.1 - 1.9e-64 213.6 2.0 3.6e-21 74.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 CRG91762.1 - 0.03 14.6 0.0 15 5.9 0.0 2.9 2 1 1 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Serine_protease PF18405.1 CRG91762.1 - 0.073 12.2 0.3 1.9 7.6 0.0 3.0 3 0 0 3 3 3 0 Gammaproteobacterial serine protease TauD PF02668.16 CRG91763.1 - 1.3e-43 149.8 0.6 1.3e-43 149.8 0.6 1.6 2 0 0 2 2 2 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CRG91763.1 - 0.0013 19.3 0.3 0.013 16.1 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF971) FCD PF07729.12 CRG91763.1 - 0.0094 16.4 0.2 0.27 11.7 0.0 2.4 2 0 0 2 2 2 1 FCD domain CsiD PF08943.10 CRG91763.1 - 0.011 14.9 0.0 0.033 13.3 0.0 1.8 1 1 0 1 1 1 0 CsiD Polysacc_deac_2 PF04748.13 CRG91763.1 - 0.04 13.1 0.1 0.09 12.0 0.0 1.6 2 0 0 2 2 2 0 Divergent polysaccharide deacetylase Glutaredoxin PF00462.24 CRG91764.1 - 5.6e-19 68.1 0.0 3.4e-17 62.4 0.0 2.6 2 1 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 CRG91764.1 - 1.4e-09 37.8 0.0 3.2e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 CRG91764.1 - 0.0058 16.9 0.0 0.64 10.4 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like RNase_T PF00929.24 CRG91765.1 - 1.9e-10 41.6 0.0 6.2e-10 39.9 0.0 1.8 1 1 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 CRG91765.1 - 0.002 17.9 0.0 0.0069 16.1 0.0 1.8 1 1 0 1 1 1 1 3'-5' exonuclease Med21 PF11221.8 CRG91765.1 - 0.14 12.5 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 Subunit 21 of Mediator complex Cnn_1N PF07989.11 CRG91766.1 - 0.01 16.0 4.4 0.096 12.9 0.5 3.3 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 Prominin PF05478.11 CRG91766.1 - 0.014 13.4 1.3 0.022 12.7 1.3 1.2 1 0 0 1 1 1 0 Prominin Beta_elim_lyase PF01212.21 CRG91767.1 - 9.5e-69 231.9 0.0 1.4e-68 231.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pkinase PF00069.25 CRG91767.1 - 3.1e-68 230.0 0.0 8.5e-68 228.6 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91767.1 - 4.3e-33 114.7 0.0 7.6e-33 113.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 CRG91767.1 - 2.8e-09 37.2 0.0 8.3e-09 35.7 0.1 1.9 2 0 0 2 2 2 1 FHA domain Kinase-like PF14531.6 CRG91767.1 - 3.5e-05 23.3 0.0 0.00011 21.7 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Yop-YscD_cpl PF16697.5 CRG91767.1 - 4.6e-05 23.7 0.0 0.00013 22.2 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain APH PF01636.23 CRG91767.1 - 0.022 14.7 0.1 5.3 6.9 0.0 2.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 CRG91767.1 - 0.029 13.7 0.1 0.055 12.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 CRG91767.1 - 0.12 11.1 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 CRG91767.1 - 0.2 11.3 0.1 0.34 10.5 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 p450 PF00067.22 CRG91768.1 - 1e-62 212.4 0.0 1.3e-62 212.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NUDIX PF00293.28 CRG91768.1 - 1.2e-07 31.8 0.9 5.2e-07 29.8 0.5 2.3 2 1 0 2 2 2 1 NUDIX domain Peptidase_M24 PF00557.24 CRG91769.1 - 2.8e-23 82.7 0.0 3.6e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 MFS_1 PF07690.16 CRG91770.1 - 2.8e-45 154.8 46.8 1.9e-40 138.9 27.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91770.1 - 3.4e-10 39.4 5.5 3.4e-10 39.4 5.5 3.2 3 0 0 3 3 3 3 Sugar (and other) transporter OATP PF03137.20 CRG91770.1 - 0.091 11.0 13.6 1.9 6.6 0.6 3.6 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Mobilization_B PF17511.2 CRG91770.1 - 2.5 8.5 6.3 4.9 7.5 0.3 2.6 2 0 0 2 2 2 0 Mobilization protein B ketoacyl-synt PF00109.26 CRG91771.1 - 3.8e-71 239.6 0.8 9.6e-71 238.3 0.4 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain HTH_51 PF18558.1 CRG91771.1 - 5.9e-36 122.2 0.0 1.5e-35 120.9 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain FSH1 PF03959.13 CRG91771.1 - 3.5e-30 105.3 0.0 7.3e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Acyl_transf_1 PF00698.21 CRG91771.1 - 3.5e-28 99.0 0.0 2.2e-27 96.4 0.0 2.2 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG91771.1 - 8.9e-28 96.7 0.0 1.9e-27 95.6 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 CRG91771.1 - 1.9e-22 79.7 0.0 3.6e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein Methyltransf_12 PF08242.12 CRG91771.1 - 9.1e-13 48.8 0.0 2.5e-12 47.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain SAT PF16073.5 CRG91771.1 - 3.5e-12 46.6 2.7 5.1e-09 36.2 0.0 3.5 3 1 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 CRG91771.1 - 6.2e-12 45.7 0.1 2.2e-11 43.9 0.1 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.6 CRG91771.1 - 1.1e-11 44.5 0.0 2.5e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase Methyltransf_25 PF13649.6 CRG91771.1 - 9.5e-08 32.7 0.0 2.5e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CRG91771.1 - 3.7e-07 29.8 2.6 1.5e-06 27.8 0.3 2.9 4 0 0 4 4 4 1 Thiolase, N-terminal domain KAsynt_C_assoc PF16197.5 CRG91771.1 - 1.1e-06 29.0 0.0 4.2e-06 27.2 0.0 1.9 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_11 PF08241.12 CRG91771.1 - 1.8e-06 28.5 0.0 5.1e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Epimerase PF01370.21 CRG91771.1 - 3.1e-06 26.9 0.0 6.1e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 CRG91771.1 - 0.0001 22.2 0.0 0.00036 20.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91771.1 - 0.00059 19.6 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG91771.1 - 0.0012 18.3 0.0 0.0027 17.1 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Polysacc_synt_2 PF02719.15 CRG91771.1 - 0.0064 15.7 0.0 0.054 12.6 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CRG91771.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 KR domain 3Beta_HSD PF01073.19 CRG91771.1 - 0.15 11.0 0.1 1.4 7.9 0.0 2.4 2 1 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family BUD22 PF09073.10 CRG91771.1 - 4.1 6.7 9.0 6.9 5.9 9.0 1.2 1 0 0 1 1 1 0 BUD22 FAD_binding_4 PF01565.23 CRG91772.1 - 2.1e-22 79.3 1.8 3.8e-22 78.5 1.8 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG91772.1 - 4.4e-08 33.1 0.0 9e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Indigoidine_A PF04227.12 CRG91772.1 - 0.0007 19.0 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein FAD_binding_5 PF00941.21 CRG91772.1 - 0.0063 16.3 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase PapA_C PF16911.5 CRG91773.1 - 0.0051 16.9 0.1 0.041 14.0 0.1 2.3 1 1 0 1 1 1 1 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus Tri3 PF07428.11 CRG91774.1 - 2.1e-06 27.0 0.0 0.037 12.9 0.0 2.1 1 1 1 2 2 2 2 15-O-acetyltransferase Tri3 ketoacyl-synt PF00109.26 CRG91775.1 - 2.7e-73 246.7 0.0 4.8e-73 245.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CRG91775.1 - 4.3e-32 110.6 0.1 8.9e-32 109.6 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PS-DH PF14765.6 CRG91775.1 - 2.1e-22 79.7 0.0 3.6e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG91775.1 - 3e-19 69.7 0.0 2.7e-17 63.3 0.0 2.2 2 0 0 2 2 2 1 Acyl transferase domain SAT PF16073.5 CRG91775.1 - 5.4e-11 42.7 2.1 5.5e-09 36.1 0.1 3.0 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 CRG91775.1 - 2e-10 40.9 0.3 1.3e-06 28.7 0.2 3.0 3 0 0 3 3 3 2 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CRG91775.1 - 9.8e-09 35.7 0.0 2.5e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CRG91775.1 - 5.3e-05 22.7 0.1 0.00011 21.7 0.1 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Epimerase PF01370.21 CRG91776.1 - 1.5e-18 67.2 0.0 2e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG91776.1 - 1.6e-11 43.7 0.0 2.2e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG91776.1 - 1.4e-09 37.8 0.1 3.2e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 CRG91776.1 - 1.6e-09 37.3 0.1 1.4e-07 30.9 0.1 2.5 2 1 0 2 2 2 1 Male sterility protein NAD_binding_10 PF13460.6 CRG91776.1 - 2.6e-06 27.4 0.0 4.7e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 CRG91776.1 - 5.3e-05 23.2 0.0 9.8e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 CRG91776.1 - 0.00048 19.4 0.0 0.00073 18.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 CRG91776.1 - 0.0052 16.3 0.0 0.0079 15.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 CRG91776.1 - 0.072 12.6 0.0 0.51 9.8 0.0 2.1 2 0 0 2 2 2 0 NmrA-like family adh_short_C2 PF13561.6 CRG91776.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Kelch_3 PF13415.6 CRG91777.1 - 1.9e-34 117.3 2.7 3.3e-07 30.4 0.0 6.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.6 CRG91777.1 - 8.5e-28 96.1 1.7 7.7e-12 45.0 0.0 5.9 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 CRG91777.1 - 2.7e-20 71.7 0.1 0.00059 19.4 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 CRG91777.1 - 5e-17 61.5 0.1 5.1e-05 23.4 0.0 6.1 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 CRG91777.1 - 1.4e-15 56.8 0.7 0.00023 21.1 0.0 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 CRG91777.1 - 5.5e-10 38.8 7.4 0.038 14.0 0.3 6.8 6 1 0 6 6 6 3 Kelch motif Band_7_C PF16200.5 CRG91779.1 - 5.3e-07 29.6 21.5 3.7 7.7 0.1 8.6 8 0 0 8 8 8 5 C-terminal region of band_7 NAAA-beta PF15508.6 CRG91779.1 - 0.00027 21.2 1.1 39 4.6 0.0 7.2 9 1 0 10 10 10 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase EH_Signature PF15611.6 CRG91779.1 - 0.19 11.1 0.0 30 3.8 0.0 3.2 1 1 1 3 3 3 0 EH_Signature domain Ribosomal_L27_C PF18471.1 CRG91779.1 - 4.3 6.7 7.0 6.6 6.1 0.7 4.3 3 2 2 5 5 5 0 Ribosomal L27 protein C-terminal domain p450 PF00067.22 CRG91780.1 - 7.5e-46 156.8 0.0 8.6e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG91781.1 - 5.2e-21 74.9 17.2 8.3e-21 74.3 17.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 CRG91781.1 - 9.9e-13 48.0 1.8 7.1e-07 28.8 0.2 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG91781.1 - 2.6e-07 30.8 0.1 8.7e-07 29.1 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Zn_clus PF00172.18 CRG91781.1 - 0.0006 19.9 8.3 0.00099 19.2 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.24 CRG91781.1 - 0.005 16.5 0.1 0.0087 15.7 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase PTR2 PF00854.21 CRG91781.1 - 0.012 14.5 1.6 0.023 13.6 1.6 1.4 1 0 0 1 1 1 0 POT family FAD_binding_2 PF00890.24 CRG91781.1 - 0.019 14.1 0.1 0.03 13.4 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_2 PF07992.14 CRG91781.1 - 0.043 13.0 0.0 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91781.1 - 0.071 11.8 0.1 0.12 11.0 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox PF00070.27 CRG91781.1 - 0.088 13.4 0.4 0.41 11.2 0.1 2.3 3 0 0 3 3 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG91781.1 - 0.18 11.0 0.0 0.38 10.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family RELT PF12606.8 CRG91781.1 - 1.7 7.7 0.0 1.7 7.7 0.0 2.8 3 0 0 3 3 3 0 Tumour necrosis factor receptor superfamily member 19 3HCDH_N PF02737.18 CRG91781.1 - 6.7 6.6 5.6 0.82 9.5 0.1 2.2 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_23 PF13489.6 CRG91782.1 - 4e-18 65.8 0.0 6.9e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG91782.1 - 1.3e-09 38.6 0.0 4.2e-09 37.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG91782.1 - 2.7e-08 34.4 0.0 5.5e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG91782.1 - 4.8e-06 27.2 0.1 5.1e-05 23.9 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91782.1 - 0.00017 21.4 0.0 0.27 11.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 CRG91782.1 - 0.0051 16.2 0.0 0.054 12.8 0.0 2.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 CRG91782.1 - 0.013 15.0 0.0 0.089 12.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase small domain PrmA PF06325.13 CRG91782.1 - 0.014 14.8 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) FAD_binding_3 PF01494.19 CRG91783.1 - 1.4e-19 70.6 0.1 2.9e-07 30.1 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 CRG91783.1 - 4.7e-05 23.5 0.0 0.00013 22.1 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 CRG91783.1 - 0.00084 18.5 0.0 0.018 14.1 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase Pyr_redox_3 PF13738.6 CRG91783.1 - 0.0013 18.1 0.0 0.0019 17.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG91783.1 - 0.011 15.0 0.0 0.022 14.0 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CRG91783.1 - 0.027 14.7 0.1 0.094 13.0 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Lycopene_cycl PF05834.12 CRG91783.1 - 0.079 12.0 0.0 1.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.27 CRG91783.1 - 0.08 13.5 0.0 0.25 11.9 0.0 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase ACD PF16671.5 CRG91783.1 - 0.15 10.4 0.0 0.23 9.7 0.0 1.2 1 0 0 1 1 1 0 Actin cross-linking domain Glyco_hydro_18 PF00704.28 CRG91784.1 - 1.2e-21 77.8 0.8 2.6e-21 76.7 0.8 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_1 PF00734.18 CRG91784.1 - 1.7e-10 40.7 11.1 1.7e-10 40.7 11.1 3.4 4 0 0 4 4 4 1 Fungal cellulose binding domain MFS_1 PF07690.16 CRG91785.1 - 3.1e-40 138.2 41.7 3.1e-40 138.2 41.7 2.3 2 1 1 3 3 3 2 Major Facilitator Superfamily SMYLE_N PF18615.1 CRG91785.1 - 0.41 10.2 2.9 0.6 9.6 2.9 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF1793 PF08760.11 CRG91786.1 - 5e-55 186.5 3.5 1e-54 185.5 3.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1793) DUF4965 PF16335.5 CRG91786.1 - 3.1e-50 170.2 2.9 1.8e-47 161.2 0.3 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4965) Flavin_Reduct PF01613.18 CRG91786.1 - 1.7e-10 41.2 0.0 3.7e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 Flavin reductase like domain DUF5127 PF17168.4 CRG91786.1 - 2e-09 37.6 0.0 3.6e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF447 PF04289.12 CRG91786.1 - 0.00039 20.2 0.1 0.0017 18.1 0.0 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF447) DUF4964 PF16334.5 CRG91786.1 - 0.065 12.8 0.0 0.18 11.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) Glyco_hydro_76 PF03663.14 CRG91787.1 - 1.5e-42 146.5 21.6 2e-42 146.1 21.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 CRG91787.1 - 3.1e-06 26.5 3.0 0.096 11.7 0.0 3.5 1 1 2 4 4 4 2 Glycosyl Hydrolase Family 88 Fungal_trans_2 PF11951.8 CRG91788.1 - 1e-10 41.0 3.0 3e-10 39.5 0.5 2.8 1 1 1 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91788.1 - 5.7e-08 32.8 9.1 1.2e-07 31.7 9.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lipase_3 PF01764.25 CRG91789.1 - 5.1e-21 75.0 0.0 7.2e-21 74.5 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 CRG91789.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Aldolase PF01081.19 CRG91789.1 - 0.014 14.8 0.0 0.022 14.2 0.0 1.3 1 0 0 1 1 1 0 KDPG and KHG aldolase DUF916 PF06030.12 CRG91789.1 - 0.028 14.5 0.1 0.05 13.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) DUF1604 PF07713.13 CRG91790.1 - 0.058 13.2 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1604) GST_N_2 PF13409.6 CRG91792.1 - 3.5e-20 72.1 0.0 6.3e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG91792.1 - 2.1e-17 62.9 0.0 5.4e-17 61.6 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 CRG91792.1 - 1.1e-07 32.0 0.0 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 CRG91792.1 - 0.00031 20.9 0.0 0.00062 19.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG91792.1 - 0.012 16.0 0.0 0.12 12.8 0.0 2.2 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain NmrA PF05368.13 CRG91794.1 - 1e-28 100.5 0.3 1.3e-28 100.1 0.3 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG91794.1 - 5.9e-21 75.2 0.0 1e-20 74.4 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG91794.1 - 2.7e-05 23.7 0.1 6.4e-05 22.5 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RVP PF00077.20 CRG91794.1 - 0.0037 17.6 0.0 0.0089 16.3 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease DapB_N PF01113.20 CRG91794.1 - 0.0061 16.7 0.9 0.02 15.0 0.9 2.0 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus adh_short PF00106.25 CRG91794.1 - 0.0082 15.6 0.2 0.012 15.1 0.2 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Semialdhyde_dh PF01118.24 CRG91794.1 - 0.012 16.1 0.6 0.029 14.8 0.4 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 CRG91794.1 - 0.034 13.2 0.0 0.066 12.3 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain 3Beta_HSD PF01073.19 CRG91794.1 - 0.038 13.0 0.1 0.086 11.8 0.1 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 CRG91794.1 - 0.041 13.8 0.1 0.082 12.8 0.1 1.5 1 0 0 1 1 1 0 KR domain Glyco_trans_4_4 PF13579.6 CRG91794.1 - 0.05 14.0 0.0 0.079 13.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain NAD_binding_2 PF03446.15 CRG91794.1 - 0.089 13.0 0.1 0.17 12.1 0.1 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 CRG91794.1 - 0.097 12.0 0.3 0.23 10.8 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sugar_tr PF00083.24 CRG91795.1 - 2.7e-111 372.6 27.7 3.2e-111 372.4 27.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91795.1 - 1.6e-25 89.8 35.2 4e-20 72.0 28.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CbtB PF09489.10 CRG91795.1 - 0.097 12.8 5.7 10 6.3 0.0 4.2 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtB) zf-LITAF-like PF10601.9 CRG91795.1 - 0.43 10.9 3.9 29 5.0 0.5 3.4 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain UNC-93 PF05978.16 CRG91795.1 - 0.44 10.2 19.6 0.03 14.0 3.3 3.3 3 0 0 3 3 3 0 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 CRG91796.1 - 1.1e-24 87.1 28.8 1.4e-24 86.7 28.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF1772 PF08592.11 CRG91796.1 - 4.2 7.7 7.2 0.39 11.0 0.7 2.6 2 1 0 3 3 3 0 Domain of unknown function (DUF1772) CN_hydrolase PF00795.22 CRG91797.1 - 5.9e-49 166.8 0.0 7.5e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase FAD_binding_3 PF01494.19 CRG91798.1 - 2.6e-25 89.4 0.0 1.3e-13 51.0 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 CRG91798.1 - 0.037 13.3 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_2 PF07992.14 CRG91798.1 - 0.19 10.9 0.0 0.35 10.0 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Glyoxalase PF00903.25 CRG91799.1 - 2.3e-07 31.1 8.0 1.5e-05 25.2 3.9 2.8 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FAA_hydrolase PF01557.18 CRG91800.1 - 1.6e-61 207.8 0.0 2.3e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF3047 PF11249.8 CRG91800.1 - 0.076 12.5 0.0 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3047) Fungal_trans PF04082.18 CRG91801.1 - 0.0016 17.5 0.7 0.078 12.0 0.1 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Ank_2 PF12796.7 CRG91802.1 - 9.2e-60 199.2 0.8 1.6e-16 60.7 0.0 4.6 1 1 4 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG91802.1 - 7.5e-45 145.7 0.6 1.3e-05 25.2 0.0 9.1 9 0 0 9 9 9 8 Ankyrin repeat Ank_4 PF13637.6 CRG91802.1 - 1.4e-43 146.7 10.1 2e-08 34.6 0.1 6.8 2 1 7 9 9 9 8 Ankyrin repeats (many copies) Ank PF00023.30 CRG91802.1 - 1.8e-41 138.8 5.3 1.5e-05 25.2 0.0 9.1 9 0 0 9 9 9 7 Ankyrin repeat Ank_5 PF13857.6 CRG91802.1 - 6.6e-40 134.7 10.0 5.8e-09 36.0 0.0 8.2 2 1 7 9 9 9 7 Ankyrin repeats (many copies) VWA_3_C PF18571.1 CRG91802.1 - 0.0044 16.9 3.4 4.8 7.1 0.1 4.4 4 0 0 4 4 4 1 von Willebrand factor type A C-terminal domain F-box-like PF12937.7 CRG91802.1 - 0.042 13.8 0.1 0.086 12.8 0.1 1.6 1 0 0 1 1 1 0 F-box-like DUF1593 PF07632.11 CRG91803.1 - 2.6e-59 200.8 0.0 4.7e-55 186.8 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1593) Fungal_trans_2 PF11951.8 CRG91804.1 - 7.8e-06 24.9 3.0 7.9e-06 24.9 2.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain DUF455 PF04305.14 CRG91805.1 - 9.5e-99 329.9 0.0 1.1e-98 329.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF455) Rieske PF00355.26 CRG91805.1 - 3.5e-06 26.9 0.0 7e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 CRG91805.1 - 0.0018 18.2 0.0 0.0048 16.8 0.0 1.7 2 0 0 2 2 2 1 Rieske-like [2Fe-2S] domain Beta-lactamase PF00144.24 CRG91806.1 - 4.4e-25 88.6 0.0 4.9e-25 88.5 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase DUF348 PF03990.14 CRG91806.1 - 0.1 12.4 0.0 0.98 9.2 0.0 2.2 2 0 0 2 2 2 0 G5-linked-Ubiquitin-like domain DUF2028 PF09667.10 CRG91806.1 - 0.13 12.3 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2028) DUF3471 PF11954.8 CRG91807.1 - 1.5e-13 51.1 0.0 2.6e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Beta-lactamase PF00144.24 CRG91807.1 - 1.6e-13 50.6 0.0 2.3e-13 50.1 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase Vip3A_N PF12495.8 CRG91807.1 - 0.14 12.0 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Bac_rhamnosid6H PF17389.2 CRG91808.1 - 1.8e-14 53.8 1.0 6.6e-14 51.9 0.3 1.9 2 0 0 2 2 2 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Bac_rhamnosid_C PF17390.2 CRG91808.1 - 1.1e-08 34.7 0.0 2.7e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain GDE_C PF06202.14 CRG91808.1 - 0.0017 17.4 0.2 0.0041 16.1 0.2 1.6 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 CRG91808.1 - 0.0024 16.8 0.1 0.0033 16.3 0.1 1.1 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid PF05592.11 CRG91808.1 - 0.025 14.6 0.0 0.092 12.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain Fungal_trans PF04082.18 CRG91809.1 - 2.2e-06 26.9 0.3 4.2e-06 26.0 0.3 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain AMP-binding PF00501.28 CRG91810.1 - 1.2e-84 284.3 0.0 1.6e-84 284.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG91810.1 - 2.9e-15 57.0 0.0 7.3e-15 55.7 0.1 1.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Aldedh PF00171.22 CRG91811.1 - 2.7e-83 280.0 0.0 3.4e-83 279.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CRG91811.1 - 0.02 14.3 0.1 0.038 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) DUF2236 PF09995.9 CRG91812.1 - 0.0019 18.4 0.0 0.0028 17.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) NopRA1 PF16201.5 CRG91812.1 - 0.11 12.0 0.2 0.22 11.1 0.2 1.4 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 MFS_1 PF07690.16 CRG91813.1 - 6.1e-16 58.3 59.7 2.8e-13 49.5 23.0 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG91813.1 - 8.1e-09 34.4 26.2 1.1e-08 34.0 26.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1689 PF07954.11 CRG91813.1 - 8.1 6.8 6.2 1.5 9.2 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1689) ADH_zinc_N PF00107.26 CRG91814.1 - 8.8e-29 100.1 0.0 8.9e-17 61.3 0.0 2.5 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91814.1 - 6e-23 80.8 4.4 1.1e-20 73.5 2.5 2.4 2 0 0 2 2 2 2 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CRG91814.1 - 1.4e-11 45.5 0.0 4e-09 37.6 0.0 2.5 2 0 0 2 2 2 2 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG91814.1 - 0.0035 16.7 0.4 0.0064 15.9 0.4 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain STAG PF08514.11 CRG91815.1 - 0.063 13.2 0.9 0.13 12.2 0.9 1.6 1 0 0 1 1 1 0 STAG domain DUF3510 PF12022.8 CRG91815.1 - 0.068 13.6 0.2 0.25 11.7 0.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) GPDPase_memb PF10110.9 CRG91815.1 - 0.098 11.4 0.4 0.13 11.0 0.4 1.1 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase MFS_1 PF07690.16 CRG91816.1 - 0.00047 19.2 5.3 0.00047 19.2 5.3 2.6 2 1 1 3 3 3 1 Major Facilitator Superfamily SPA PF08616.10 CRG91816.1 - 0.06 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Stabilization of polarity axis Epimerase PF01370.21 CRG91817.1 - 1.1e-14 54.5 0.0 6.3e-14 52.0 0.0 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CRG91817.1 - 8.8e-08 31.6 0.0 0.0057 15.8 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain NmrA PF05368.13 CRG91817.1 - 6.1e-07 29.2 0.0 0.0021 17.7 0.0 2.1 2 0 0 2 2 2 2 NmrA-like family 3Beta_HSD PF01073.19 CRG91817.1 - 1.5e-05 24.2 0.1 0.0004 19.5 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 CRG91817.1 - 0.00034 20.1 0.1 0.027 13.9 0.0 2.6 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 CRG91817.1 - 0.0016 18.0 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 CRG91817.1 - 0.0039 17.1 0.0 0.008 16.1 0.0 1.7 1 0 0 1 1 1 1 NAD(P)H-binding DUF4974 PF16344.5 CRG91817.1 - 0.0096 15.9 0.1 0.041 13.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4974) Sugar_tr PF00083.24 CRG91818.1 - 5.9e-105 351.7 25.7 8.1e-105 351.3 25.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91818.1 - 2.3e-20 72.9 32.6 6.1e-19 68.2 23.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF3425 PF11905.8 CRG91818.1 - 2e-13 50.4 0.0 4.5e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 CRG91818.1 - 1 9.5 9.8 2 8.6 9.8 1.4 1 0 0 1 1 1 0 bZIP transcription factor NmrA PF05368.13 CRG91819.1 - 2.5e-39 135.2 0.0 3.5e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG91819.1 - 6.3e-10 39.2 0.0 9e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG91819.1 - 0.00086 18.8 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 CRG91819.1 - 0.031 14.5 0.0 0.056 13.7 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 CRG91819.1 - 0.038 14.2 0.0 0.068 13.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pkinase PF00069.25 CRG91820.1 - 5.1e-22 78.5 0.0 1.7e-21 76.8 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91820.1 - 4.7e-07 29.4 1.1 6.7e-06 25.6 1.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Glyco_hydro_18 PF00704.28 CRG91822.1 - 2.7e-66 224.4 0.0 3.2e-66 224.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Cas_CT1975 PF09344.10 CRG91823.1 - 0.013 15.0 0.1 0.014 14.9 0.1 1.1 1 0 0 1 1 1 0 CT1975-like protein Cu-oxidase_3 PF07732.15 CRG91824.1 - 1.3e-44 151.0 10.9 4.3e-41 139.7 3.6 3.6 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_2 PF07731.14 CRG91824.1 - 7.4e-39 132.6 7.3 7.3e-35 119.7 0.1 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 CRG91824.1 - 4.5e-31 108.1 1.2 8.1e-26 91.0 0.1 4.1 4 1 0 4 4 4 2 Multicopper oxidase E1_DerP2_DerF2 PF02221.15 CRG91824.1 - 0.094 13.2 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 ML domain Zn_clus PF00172.18 CRG91825.1 - 8.1e-07 29.1 9.8 1.4e-06 28.3 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG91825.1 - 8.6e-07 28.3 0.2 2e-06 27.0 0.0 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-RING_2 PF13639.6 CRG91826.1 - 2e-10 40.9 10.1 2.9e-10 40.3 10.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CRG91826.1 - 6.1e-07 29.2 9.2 9.8e-07 28.6 9.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 CRG91826.1 - 1.6e-06 27.8 9.4 2.6e-06 27.2 9.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG91826.1 - 5.4e-06 26.3 2.5 5.4e-06 26.3 2.5 1.7 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 CRG91826.1 - 4.3e-05 23.4 9.2 6.4e-05 22.8 9.2 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 CRG91826.1 - 6.3e-05 22.6 9.3 6.3e-05 22.6 9.3 1.7 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 CRG91826.1 - 6.7e-05 23.1 12.1 0.00021 21.5 12.1 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 CRG91826.1 - 0.00071 19.4 7.3 0.0011 18.7 7.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG91826.1 - 0.0009 19.1 10.1 0.0063 16.4 9.2 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 CRG91826.1 - 0.0023 18.0 8.9 0.0042 17.1 9.0 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger BatA PF07584.11 CRG91826.1 - 0.027 14.8 0.1 0.042 14.2 0.1 1.2 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal RINGv PF12906.7 CRG91826.1 - 0.061 13.5 9.2 0.12 12.5 9.2 1.5 1 0 0 1 1 1 0 RING-variant domain CD34_antigen PF06365.12 CRG91826.1 - 0.072 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family GPI2 PF06432.11 CRG91826.1 - 0.093 12.2 0.0 0.2 11.1 0.0 1.5 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase DUF5305 PF17231.2 CRG91826.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Zn_ribbon_17 PF17120.5 CRG91826.1 - 0.25 11.0 14.8 0.038 13.6 11.0 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 CRG91826.1 - 1.3 9.4 7.8 2.8 8.3 7.8 1.6 1 1 0 1 1 1 0 RING-like domain zf-C3HC4_4 PF15227.6 CRG91826.1 - 3.1 8.0 8.3 23 5.3 8.2 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 CRG91826.1 - 3.2 8.0 13.9 2.4 8.4 9.5 2.6 2 1 0 2 2 1 0 FANCL C-terminal domain Zf_RING PF16744.5 CRG91826.1 - 7.3 6.8 11.1 1.6 8.9 4.6 2.2 1 1 1 2 2 2 0 KIAA1045 RING finger adh_short PF00106.25 CRG91827.1 - 1.2e-15 57.5 0.1 1.3e-15 57.3 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG91827.1 - 7.7e-08 32.5 0.0 9.1e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG91827.1 - 1.2e-06 28.3 0.0 1.5e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Fungal_trans PF04082.18 CRG91828.1 - 5.1e-11 42.1 0.1 1.1e-10 41.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91828.1 - 3.9e-07 30.1 11.6 3.9e-07 30.1 11.6 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_10 PF13460.6 CRG91829.1 - 1.8e-06 28.0 0.0 0.00014 21.8 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding NmrA PF05368.13 CRG91829.1 - 5.2e-05 22.9 0.0 0.00045 19.8 0.0 2.2 1 1 0 1 1 1 1 NmrA-like family Homeodomain PF00046.29 CRG91830.1 - 6.5e-15 54.7 1.8 1.7e-14 53.4 1.8 1.8 1 0 0 1 1 1 1 Homeodomain DUF3431 PF11913.8 CRG91831.1 - 7.4e-63 212.2 0.0 1e-62 211.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Herpes_ICP4_C PF03585.14 CRG91831.1 - 0.099 11.3 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein C-terminal region Amino_oxidase PF01593.24 CRG91832.1 - 1.5e-46 159.7 0.3 4.4e-45 154.8 0.3 2.6 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CRG91832.1 - 1.6e-16 60.3 0.6 3.8e-16 59.1 0.6 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG91832.1 - 2.7e-06 26.8 0.2 3.8e-05 23.1 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG91832.1 - 2.3e-05 24.8 0.2 5.2e-05 23.7 0.2 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG91832.1 - 0.00026 19.8 0.6 0.00026 19.8 0.6 1.5 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 CRG91832.1 - 0.00056 19.2 0.8 0.00091 18.5 0.8 1.2 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CRG91832.1 - 0.00077 18.9 0.6 0.001 18.5 0.6 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 CRG91832.1 - 0.001 18.8 4.8 0.0093 15.6 4.8 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 CRG91832.1 - 0.0031 16.9 0.3 0.005 16.2 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 CRG91832.1 - 0.008 15.5 0.6 0.012 14.9 0.6 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_binding_2 PF00890.24 CRG91832.1 - 0.012 14.7 1.8 0.018 14.2 1.8 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 CRG91832.1 - 0.11 12.5 1.9 8.7 6.3 0.7 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 CRG91832.1 - 0.16 11.8 0.3 0.29 11.0 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 CRG91832.1 - 0.3 10.3 1.1 0.64 9.2 1.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Acetyltransf_3 PF13302.7 CRG91833.1 - 2.2e-21 77.0 0.0 2.8e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG91833.1 - 9.9e-06 25.8 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 CRG91833.1 - 0.12 12.0 0.0 0.29 10.8 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FAD_binding_2 PF00890.24 CRG91834.1 - 3.1e-94 316.4 0.0 3.5e-94 316.2 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG91834.1 - 2.3e-07 30.9 0.2 1.1e-06 28.8 0.2 2.2 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG91834.1 - 2.9e-07 30.0 1.4 2.2e-05 23.8 0.7 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG91834.1 - 2.3e-06 27.4 0.1 7.7e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CRG91834.1 - 2.7e-06 26.9 0.2 5.6e-06 25.8 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 CRG91834.1 - 1.2e-05 24.9 0.0 1.7e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 CRG91834.1 - 0.00012 21.3 0.5 0.00012 21.3 0.5 2.5 3 0 0 3 3 3 1 Glucose inhibited division protein A Thi4 PF01946.17 CRG91834.1 - 0.00016 21.0 0.4 0.00035 19.9 0.4 1.6 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 CRG91834.1 - 0.00017 20.4 2.6 0.00031 19.6 0.5 2.3 3 0 0 3 3 3 1 HI0933-like protein Lycopene_cycl PF05834.12 CRG91834.1 - 0.00036 19.7 0.5 0.00058 19.0 0.5 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 CRG91834.1 - 0.0011 19.5 0.8 0.017 15.7 0.5 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG91834.1 - 0.0078 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 FAD-NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 CRG91834.1 - 0.014 15.0 0.1 0.027 14.0 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 CRG91834.1 - 0.023 14.0 0.7 0.059 12.7 0.3 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 CRG91834.1 - 0.024 13.9 1.7 0.044 13.0 1.7 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG91834.1 - 0.083 11.7 0.5 0.12 11.2 0.5 1.2 1 0 0 1 1 1 0 Tryptophan halogenase TrkA_N PF02254.18 CRG91834.1 - 0.13 12.5 0.9 0.38 11.0 0.4 2.0 2 0 0 2 2 1 0 TrkA-N domain DUF2235 PF09994.9 CRG91836.1 - 1e-100 336.8 0.1 1.4e-100 336.4 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF896 PF05979.12 CRG91836.1 - 0.03 14.2 0.2 0.094 12.6 0.2 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) An_peroxidase PF03098.15 CRG91837.1 - 1.4e-40 139.4 0.1 4.5e-27 94.8 0.1 3.1 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 CRG91837.1 - 2.4e-15 56.2 0.0 8.2e-08 31.4 0.0 2.2 2 0 0 2 2 2 2 Cytochrome P450 FAD_binding_3 PF01494.19 CRG91838.1 - 8.7e-69 232.4 0.0 1.1e-68 232.1 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Ribonuc_L-PSP PF01042.21 CRG91838.1 - 6.1e-09 35.9 0.0 1.2e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Endoribonuclease L-PSP DAO PF01266.24 CRG91838.1 - 6.5e-09 35.8 0.1 5.1e-06 26.3 0.4 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 CRG91838.1 - 8.4e-07 28.4 0.3 2e-06 27.2 0.3 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG91838.1 - 1.3e-05 24.6 0.6 5.7e-05 22.5 0.1 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG91838.1 - 5e-05 22.7 0.0 0.00012 21.5 0.1 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG91838.1 - 0.00018 21.7 0.0 0.00053 20.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG91838.1 - 0.0002 20.2 0.0 0.00032 19.5 0.0 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CRG91838.1 - 0.00029 21.4 0.2 0.034 14.7 0.2 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 CRG91838.1 - 0.0005 19.2 0.8 0.002 17.3 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein Thi4 PF01946.17 CRG91838.1 - 0.00059 19.1 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CRG91838.1 - 0.00059 19.3 0.0 0.0013 18.2 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase TrkA_N PF02254.18 CRG91838.1 - 0.025 14.8 0.0 0.048 13.9 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain DUF1488 PF07369.11 CRG91838.1 - 0.082 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) NAD_binding_7 PF13241.6 CRG91838.1 - 0.12 12.9 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Mus7 PF09462.10 CRG91840.1 - 6.6e-193 642.9 0.1 9.1e-193 642.5 0.1 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family Amidohydro_2 PF04909.14 CRG91842.1 - 1.6e-35 123.3 0.8 2.1e-35 122.9 0.8 1.2 1 0 0 1 1 1 1 Amidohydrolase Fungal_trans PF04082.18 CRG91843.1 - 6.9e-10 38.4 0.3 1.1e-09 37.8 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91843.1 - 1.7e-05 24.8 10.9 3.5e-05 23.8 10.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAPA-1 PF04795.12 CRG91844.1 - 4.2e-30 104.4 5.1 4.2e-30 104.4 5.1 3.4 3 1 0 3 3 3 1 PAPA-1-like conserved region Pex14_N PF04695.13 CRG91845.1 - 5e-41 141.0 2.7 5e-41 141.0 2.7 2.8 3 0 0 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_S15 PF00312.22 CRG91845.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S15 Virul_Fac PF10139.9 CRG91845.1 - 1.3 7.2 5.2 0.97 7.6 0.4 2.0 2 0 0 2 2 2 0 Putative bacterial virulence factor RRN3 PF05327.11 CRG91845.1 - 1.9 6.9 6.6 3.7 6.0 6.6 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SRA1 PF07304.11 CRG91846.1 - 2.7e-12 46.7 0.0 2.7e-12 46.7 0.0 3.5 3 0 0 3 3 3 1 Steroid receptor RNA activator (SRA1) WD40 PF00400.32 CRG91846.1 - 7.5e-09 36.1 3.5 0.41 11.6 0.0 6.7 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG91846.1 - 0.0023 18.2 0.1 0.11 12.8 0.0 3.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.7 CRG91846.1 - 0.0052 16.5 0.0 0.043 13.5 0.0 2.2 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 Prp18 PF02840.15 CRG91846.1 - 0.0088 16.1 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Prp18 domain RRM_1 PF00076.22 CRG91847.1 - 7.6e-17 60.9 0.0 1.5e-16 59.9 0.0 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 CRG91847.1 - 0.0025 17.9 0.0 0.0036 17.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 CRG91847.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif B12D PF06522.11 CRG91848.1 - 0.00088 19.0 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit ThrE PF06738.12 CRG91848.1 - 0.092 12.1 0.0 0.11 11.8 0.0 1.0 1 0 0 1 1 1 0 Putative threonine/serine exporter COX6B PF02297.17 CRG91849.1 - 9.6e-18 64.2 5.4 1.2e-17 63.9 5.4 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 CRG91849.1 - 0.054 13.5 1.6 0.11 12.5 1.4 1.6 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 CRG91849.1 - 0.085 12.8 1.0 0.17 11.9 1.0 1.5 1 1 0 1 1 1 0 APOBEC-like C-terminal domain Mito_carr PF00153.27 CRG91850.1 - 2.8e-60 200.3 0.3 5.8e-20 71.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein TauE PF01925.19 CRG91850.1 - 0.047 13.3 0.3 0.047 13.3 0.3 1.5 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE tRNA-synt_2d PF01409.20 CRG91852.1 - 5.3e-49 166.9 0.5 7.5e-27 94.4 0.0 2.4 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 CRG91852.1 - 5.5e-28 97.2 0.0 1.5e-27 95.9 0.0 1.8 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain GrpE PF01025.19 CRG91853.1 - 4.5e-43 146.8 7.3 6.5e-43 146.3 7.3 1.3 1 0 0 1 1 1 1 GrpE NPH3 PF03000.14 CRG91853.1 - 0.013 15.2 0.4 0.018 14.7 0.4 1.3 1 0 0 1 1 1 0 NPH3 family Peptidase_S49 PF01343.18 CRG91853.1 - 0.036 14.0 0.6 0.069 13.1 0.6 1.5 1 0 0 1 1 1 0 Peptidase family S49 RRP14 PF15459.6 CRG91853.1 - 4.1 8.1 10.2 14 6.4 0.5 3.0 2 1 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 Uds1 PF15456.6 CRG91854.1 - 3.7e-22 78.9 5.3 3.7e-22 78.9 5.3 2.2 2 0 0 2 2 2 1 Up-regulated During Septation Calcipressin PF04847.12 CRG91855.1 - 9e-34 116.8 0.2 1.6e-33 116.0 0.2 1.4 1 1 0 1 1 1 1 Calcipressin Phage_cap_P2 PF05125.12 CRG91855.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein, P2 family ATE_C PF04377.15 CRG91856.1 - 1.9e-47 161.3 1.0 1.9e-47 161.3 1.0 2.1 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 CRG91856.1 - 6.6e-21 74.5 6.0 1.6e-20 73.3 6.0 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Acetyltransf_6 PF13480.7 CRG91856.1 - 0.02 15.0 0.5 0.042 14.0 0.5 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain NUDIX PF00293.28 CRG91857.1 - 8e-19 68.0 0.2 9.8e-19 67.7 0.2 1.1 1 0 0 1 1 1 1 NUDIX domain RNA_pol_A_bac PF01000.26 CRG91858.1 - 1.1e-27 96.6 0.0 1.8e-27 95.9 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 CRG91858.1 - 4.1e-16 58.2 0.0 6.1e-16 57.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain PriA_CRR PF18319.1 CRG91858.1 - 0.046 13.7 1.8 0.046 13.7 1.8 1.7 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain I_LWEQ PF01608.17 CRG91859.1 - 0.071 13.4 0.2 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 I/LWEQ domain DUF1664 PF07889.12 CRG91859.1 - 0.12 12.4 0.2 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3446 PF11928.8 CRG91859.1 - 7.7 6.9 9.2 4.6 7.6 0.3 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain Cytochrom_C PF00034.21 CRG91860.1 - 3.9e-11 43.9 0.0 4.9e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 CRG91860.1 - 6.4e-08 32.8 2.6 3.7e-07 30.4 2.6 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 CRG91860.1 - 0.0018 18.0 0.1 0.0038 16.9 0.1 1.6 2 0 0 2 2 2 1 Cytochrome c-550 domain CCP_MauG PF03150.14 CRG91860.1 - 0.063 13.9 0.0 0.068 13.8 0.0 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase RNase_PH PF01138.21 CRG91862.1 - 1.3e-07 32.2 0.3 5e-06 27.0 0.1 2.9 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 Pkinase PF00069.25 CRG91863.1 - 8e-58 195.9 0.0 1.2e-57 195.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91863.1 - 1.3e-33 116.4 0.0 6.9e-31 107.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 CRG91863.1 - 0.0029 16.6 0.0 0.0049 15.9 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 CRG91863.1 - 0.019 13.9 0.0 0.028 13.4 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Stc1 PF12898.7 CRG91864.1 - 3.4e-16 59.6 10.1 6.2e-16 58.7 10.1 1.4 1 0 0 1 1 1 1 Stc1 domain E6 PF00518.17 CRG91864.1 - 0.55 10.7 7.3 1.4 9.4 7.3 1.6 1 1 0 1 1 1 0 Early Protein (E6) zf-C6H2 PF15801.5 CRG91864.1 - 4.1 7.8 9.0 0.57 10.5 1.7 2.5 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding CENP-B_dimeris PF09026.10 CRG91864.1 - 4.2 7.8 13.7 2.2 8.7 4.6 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 CRG91864.1 - 6.1 6.5 7.9 9.3 5.9 1.5 2.5 1 1 0 2 2 2 0 FAM176 family Cytochrome_C7 PF14522.6 CRG91864.1 - 6.1 6.9 8.3 43 4.2 4.9 2.5 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c Nop14 PF04147.12 CRG91864.1 - 6.6 4.8 8.3 8 4.5 8.3 1.1 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 CRG91864.1 - 8.4 6.8 12.5 7 7.1 4.6 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DZR PF12773.7 CRG91864.1 - 9.2 6.4 9.2 27 4.9 6.0 2.8 2 1 0 2 2 2 0 Double zinc ribbon RAB3GAP2_N PF14655.6 CRG91865.1 - 0.1 11.8 0.9 0.16 11.2 0.9 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus TFIIA PF03153.13 CRG91865.1 - 0.73 9.8 21.2 3.8 7.4 0.8 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Stn1 PF10451.9 CRG91866.1 - 3.7e-13 49.0 0.1 8.1e-06 25.0 0.0 2.1 2 0 0 2 2 2 2 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 CRG91866.1 - 0.055 13.5 0.4 1.4 8.9 0.4 2.5 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain PknG_rubred PF16919.5 CRG91866.1 - 0.55 10.4 3.2 0.5 10.5 0.2 2.0 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain AP_endonuc_2 PF01261.24 CRG91867.1 - 4.3e-26 91.7 0.0 6.7e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel Ig_mannosidase PF17753.1 CRG91868.1 - 1.9e-12 46.8 0.0 4.4e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2 PF00703.21 CRG91868.1 - 5e-09 36.8 0.0 1.2e-08 35.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Mannosidase_ig PF17786.1 CRG91868.1 - 5.2e-09 36.6 0.0 1.3e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain zf-C2H2_4 PF13894.6 CRG91869.1 - 0.00055 20.5 3.2 0.029 15.2 0.3 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_9 PF16293.5 CRG91869.1 - 0.0013 18.6 0.0 2.2 8.2 0.0 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 CRG91869.1 - 0.035 14.5 0.2 0.65 10.4 0.2 2.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 CRG91869.1 - 0.036 14.4 0.5 9.4 6.6 0.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn_Tnp_IS1595 PF12760.7 CRG91869.1 - 0.04 13.9 0.8 2 8.4 0.2 2.8 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C2H2 PF00096.26 CRG91869.1 - 0.27 11.8 5.4 0.53 10.8 0.3 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Fungal_trans PF04082.18 CRG91870.1 - 7.3e-17 61.3 0.9 1.5e-16 60.2 0.9 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 CRG91870.1 - 3.4e-07 30.4 12.0 0.006 17.0 0.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG91870.1 - 0.00074 20.2 9.7 0.24 12.4 0.4 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger DUF4216 PF13952.6 CRG91870.1 - 0.095 13.1 0.1 6.4 7.2 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4216) GAGA PF09237.11 CRG91870.1 - 0.11 12.3 1.3 0.25 11.2 1.3 1.5 1 0 0 1 1 1 0 GAGA factor zf-met PF12874.7 CRG91870.1 - 0.24 11.9 2.5 7.4 7.1 0.0 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 CRG91870.1 - 1.4 9.5 5.0 0.95 10.0 1.1 2.5 2 0 0 2 2 2 0 Zinc-finger double domain Aldo_ket_red PF00248.21 CRG91871.1 - 6.2e-44 150.4 0.0 3.4e-36 125.0 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family DUF3557 PF12078.8 CRG91871.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) DUF705 PF05152.12 CRG91871.1 - 0.11 12.0 0.0 0.24 10.8 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF705) FAD_oxidored PF12831.7 CRG91872.1 - 1.9e-117 393.3 0.0 2.7e-117 392.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mannosidase_ig PF17786.1 CRG91872.1 - 3.9e-14 53.0 0.1 1e-13 51.7 0.1 1.8 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 CRG91872.1 - 2e-08 34.9 0.1 4.7e-08 33.7 0.1 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 DUF2953 PF11167.8 CRG91872.1 - 0.011 15.8 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2953) Glyco_hydro_2_N PF02837.18 CRG91872.1 - 0.099 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, sugar binding domain Pyr_redox_2 PF07992.14 CRG91872.1 - 0.18 11.0 0.0 0.31 10.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG91872.1 - 0.2 10.9 0.9 0.37 10.0 0.9 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG91872.1 - 0.41 9.7 1.5 0.95 8.5 1.5 1.6 1 0 0 1 1 1 0 FAD binding domain Lipase_GDSL_2 PF13472.6 CRG91873.1 - 1.4e-23 84.2 0.0 3.1e-23 83.1 0.0 1.6 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 CRG91873.1 - 8.1e-17 61.9 0.0 1.5e-16 61.0 0.0 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Sugar_tr PF00083.24 CRG91874.1 - 8.2e-84 282.1 14.4 1.8e-81 274.3 14.4 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91874.1 - 5.3e-36 124.3 31.6 7.3e-25 87.6 16.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG91874.1 - 2.2e-06 26.4 3.9 2.2e-06 26.4 3.9 1.9 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 CRG91874.1 - 0.00022 19.9 2.0 0.00022 19.9 2.0 2.9 2 2 0 2 2 2 2 MFS/sugar transport protein Glyco_hydro_28 PF00295.17 CRG91875.1 - 7.9e-10 38.3 0.1 1.4e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CRG91875.1 - 4.4e-08 33.2 5.4 6e-07 29.5 5.3 2.5 1 1 1 2 2 2 1 Pectate lyase superfamily protein Inv-AAD PF18785.1 CRG91876.1 - 2.2e-44 150.5 0.0 3e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 CRG91876.1 - 1e-10 41.4 0.0 3.6e-10 39.6 0.0 1.9 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 CRG91876.1 - 0.00055 19.9 0.0 0.00097 19.1 0.0 1.3 1 1 0 1 1 1 1 APOBEC-like N-terminal domain SNAD4 PF18750.1 CRG91876.1 - 0.059 13.5 0.0 0.097 12.8 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 CRG91876.1 - 0.12 12.5 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Beta-lactamase PF00144.24 CRG91877.1 - 4.3e-41 141.3 0.0 6.1e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Pyr_redox_2 PF07992.14 CRG91878.1 - 2.5e-36 125.4 0.0 3.2e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG91878.1 - 3.3e-17 62.8 0.2 1.4e-10 41.6 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG91878.1 - 7.2e-08 31.9 0.0 1.5e-05 24.3 0.1 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG91878.1 - 2.6e-06 26.9 0.0 0.0076 15.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG91878.1 - 0.0043 16.7 0.1 3.3 7.2 0.1 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase TrkA_N PF02254.18 CRG91878.1 - 0.0043 17.3 0.2 1.6 9.0 0.0 2.6 3 0 0 3 3 3 1 TrkA-N domain NAD_binding_9 PF13454.6 CRG91878.1 - 0.0076 16.3 0.0 8.9 6.3 0.0 3.0 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CRG91878.1 - 0.0096 16.1 0.0 0.24 11.7 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 CRG91878.1 - 0.01 14.9 0.0 2.6 7.0 0.0 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein HI0933_like PF03486.14 CRG91878.1 - 0.052 12.3 0.0 10 4.7 0.0 2.9 3 0 0 3 3 3 0 HI0933-like protein DUF1188 PF06690.11 CRG91878.1 - 0.055 13.0 0.0 0.26 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) Eno-Rase_NADH_b PF12242.8 CRG91878.1 - 0.076 12.8 0.1 3 7.7 0.0 2.9 2 1 1 3 3 3 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DnaJ PF00226.31 CRG91879.1 - 5.8e-22 77.6 4.4 5.8e-22 77.6 4.4 2.6 2 1 0 2 2 2 1 DnaJ domain RPT PF13446.6 CRG91879.1 - 0.04 13.8 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 A repeated domain in UCH-protein AUDH_Cupin PF18637.1 CRG91879.1 - 0.087 12.8 0.7 0.19 11.8 0.7 1.5 1 0 0 1 1 1 0 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain Usp PF00582.26 CRG91880.1 - 3.1e-18 66.7 6.7 1.3e-12 48.5 0.1 3.3 4 0 0 4 4 4 2 Universal stress protein family ATP-synt_ab PF00006.25 CRG91881.1 - 1.6e-62 210.9 0.0 6.5e-46 156.7 0.0 2.2 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 CRG91881.1 - 1.1e-12 48.3 0.4 2.1e-12 47.3 0.4 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Trp_syntA PF00290.20 CRG91882.1 - 6.7e-93 310.3 0.0 1.3e-92 309.4 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 CRG91882.1 - 9.4e-52 176.2 1.1 1.7e-51 175.4 1.1 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ADH_zinc_N PF00107.26 CRG91885.1 - 4e-22 78.6 0.5 7.7e-22 77.7 0.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG91885.1 - 1.3e-08 36.0 0.1 3.5e-08 34.6 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91885.1 - 0.00017 21.4 0.0 0.00063 19.6 0.0 1.9 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 CRG91885.1 - 0.12 11.8 0.6 0.23 10.9 0.6 1.5 1 0 0 1 1 1 0 short chain dehydrogenase AA_permease_2 PF13520.6 CRG91886.1 - 4.9e-65 220.0 35.2 6.6e-65 219.6 35.2 1.1 1 0 0 1 1 1 1 Amino acid permease CCB1 PF12046.8 CRG91886.1 - 0.65 9.3 3.0 20 4.5 0.3 3.0 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B Glyco_hydro_28 PF00295.17 CRG91887.1 - 4.9e-26 91.6 0.2 6.8e-26 91.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CRG91887.1 - 3e-08 33.8 8.9 6.9e-07 29.3 1.0 3.1 1 1 1 2 2 2 2 Pectate lyase superfamily protein adh_short_C2 PF13561.6 CRG91888.1 - 1.4e-25 90.3 0.0 1.8e-25 89.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91888.1 - 1.1e-19 70.6 0.0 1.4e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG91888.1 - 0.023 14.6 0.0 0.033 14.1 0.0 1.2 1 0 0 1 1 1 0 KR domain THF_DHG_CYH_C PF02882.19 CRG91888.1 - 0.035 13.4 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Sugar_tr PF00083.24 CRG91889.1 - 1.5e-98 330.6 24.2 2.7e-98 329.8 24.2 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter UbiA PF01040.18 CRG91889.1 - 1.4e-24 86.8 3.3 1.4e-24 86.8 3.3 3.2 3 0 0 3 3 3 1 UbiA prenyltransferase family MFS_1 PF07690.16 CRG91889.1 - 5.2e-19 68.4 33.9 5.2e-19 68.4 33.9 3.1 2 1 1 3 3 3 2 Major Facilitator Superfamily GFO_IDH_MocA PF01408.22 CRG91889.1 - 2.4e-18 67.1 0.0 6.3e-18 65.7 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Acetyltransf_1 PF00583.25 CRG91889.1 - 1.3e-06 28.6 0.0 4.3e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG91889.1 - 1.4e-06 28.3 0.0 3.1e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG91889.1 - 3.1e-06 27.5 0.0 8.7e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Semialdhyde_dh PF01118.24 CRG91889.1 - 0.0013 19.2 0.0 0.0039 17.6 0.0 1.9 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Ish1 PF10281.9 CRG91889.1 - 0.1 12.9 0.9 67 3.9 0.2 3.6 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein p450 PF00067.22 CRG91890.1 - 3.2e-57 194.3 0.4 4.2e-57 193.9 0.4 1.0 1 0 0 1 1 1 1 Cytochrome P450 BTB_2 PF02214.22 CRG91891.1 - 1.7e-07 31.5 0.7 0.0014 19.0 0.1 3.0 3 0 0 3 3 3 2 BTB/POZ domain GST_N PF02798.20 CRG91892.1 - 3e-10 40.3 0.5 5.8e-10 39.4 0.1 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 CRG91892.1 - 2.4e-07 31.1 0.0 7.9e-07 29.4 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 CRG91892.1 - 2.7e-06 27.6 0.1 5.9e-06 26.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG91892.1 - 0.13 12.3 0.0 0.37 10.9 0.0 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 CRG91892.1 - 0.16 12.7 0.0 0.45 11.3 0.0 2.0 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain NDUF_B4 PF07225.12 CRG91893.1 - 1.3e-06 28.3 0.0 1.5e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) MitoNEET_N PF10660.9 CRG91893.1 - 0.045 13.8 0.2 0.063 13.3 0.2 1.2 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus EamA PF00892.20 CRG91893.1 - 0.076 13.2 0.0 0.085 13.0 0.0 1.1 1 0 0 1 1 1 0 EamA-like transporter family SAP18 PF06487.12 CRG91894.1 - 1.1e-48 165.0 0.0 1.3e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Prp18 PF02840.15 CRG91895.1 - 4.8e-56 188.8 0.1 4.8e-56 188.8 0.1 2.0 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 CRG91895.1 - 2.3e-11 43.0 0.5 2.3e-11 43.0 0.5 2.5 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like DUF4629 PF15442.6 CRG91895.1 - 1.1 9.5 17.9 2.5 8.3 17.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4629) CDC27 PF09507.10 CRG91895.1 - 1.1 8.6 26.8 1.7 8.0 26.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 CRG91895.1 - 3.8 5.7 16.6 5.7 5.1 16.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Casc1_N PF15927.5 CRG91895.1 - 8.5 6.0 29.8 27 4.4 29.8 1.8 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus Pyr_redox_3 PF13738.6 CRG91896.1 - 0.00058 19.2 0.0 0.00095 18.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Arf PF00025.21 CRG91897.1 - 2e-38 131.6 0.0 1.7e-25 89.5 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 CRG91897.1 - 2.8e-14 53.1 0.0 3.6e-08 33.0 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 CRG91897.1 - 1.8e-10 41.0 0.0 6e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 CRG91897.1 - 2e-07 30.6 0.0 3.1e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 CRG91897.1 - 3.6e-06 26.7 0.0 0.0014 18.3 0.0 2.6 2 1 0 2 2 2 2 Ras family SRPRB PF09439.10 CRG91897.1 - 3.2e-05 23.5 0.0 0.00018 21.0 0.0 2.2 3 0 0 3 3 3 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 CRG91897.1 - 0.00013 22.0 0.0 0.0003 20.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 CRG91897.1 - 0.0084 15.7 0.0 0.086 12.4 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain PIGA PF08288.12 CRG91899.1 - 5.3e-43 145.5 1.2 5.3e-43 145.5 1.2 1.8 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 CRG91899.1 - 7.7e-28 97.6 0.3 1.3e-27 96.9 0.3 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 CRG91899.1 - 3.9e-27 94.9 0.0 5.8e-27 94.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 CRG91899.1 - 2.3e-23 83.1 0.2 4.5e-23 82.2 0.1 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 CRG91899.1 - 9.6e-12 45.6 0.0 1.7e-11 44.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 CRG91899.1 - 7.4e-05 22.8 0.1 0.00015 21.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 CRG91899.1 - 0.0053 17.1 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 DEAD PF00270.29 CRG91900.1 - 4.7e-34 117.7 0.0 2.8e-16 59.8 0.0 2.7 2 1 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG91900.1 - 3.8e-20 72.3 0.1 1.1e-19 70.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 CRG91900.1 - 6.4e-09 36.0 0.0 8e-08 32.5 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CRG91900.1 - 0.026 14.9 0.0 0.083 13.2 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CRG91900.1 - 0.077 13.3 0.2 3.4 8.0 0.2 2.6 1 1 0 1 1 1 0 AAA domain AA_permease_2 PF13520.6 CRG91901.1 - 5e-70 236.5 40.1 6.1e-70 236.2 40.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG91901.1 - 2.4e-21 75.9 34.7 2.9e-21 75.6 34.7 1.0 1 0 0 1 1 1 1 Amino acid permease MPS-4 PF17523.2 CRG91901.1 - 2.1 8.5 4.8 4.1 7.6 1.5 2.9 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 AMP-binding PF00501.28 CRG91902.1 - 2.2e-30 105.6 0.0 3.3e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme RELT PF12606.8 CRG91902.1 - 0.02 13.9 1.1 0.043 12.8 1.1 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 Zn_clus PF00172.18 CRG91903.1 - 7.4e-08 32.4 12.3 1.3e-07 31.6 12.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 CRG91903.1 - 0.0093 14.8 0.0 0.013 14.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain GMC_oxred_N PF00732.19 CRG91904.1 - 2.6e-44 151.8 0.9 3.7e-44 151.3 0.9 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 CRG91904.1 - 2.2e-29 102.8 0.3 6.9e-29 101.2 0.0 1.9 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 CRG91904.1 - 1.4e-06 27.6 0.3 4.8e-06 25.9 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG91904.1 - 1.8e-05 24.1 0.5 3.8e-05 23.1 0.3 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG91904.1 - 5.9e-05 22.5 0.1 0.00013 21.4 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG91904.1 - 8.1e-05 22.8 0.1 0.00032 20.9 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG91904.1 - 0.0005 19.4 0.1 0.0013 18.1 0.1 1.6 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 CRG91904.1 - 0.0021 17.5 1.0 0.0049 16.3 1.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG91904.1 - 0.006 15.3 0.1 0.018 13.8 0.2 1.7 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 CRG91904.1 - 0.031 13.9 6.9 3.3 7.2 7.0 3.5 2 1 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 CRG91904.1 - 0.11 11.6 0.1 0.2 10.7 0.1 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A DUF870 PF05912.11 CRG91904.1 - 0.11 12.5 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Caenorhabditis elegans protein of unknown function (DUF870) Pyr_redox_3 PF13738.6 CRG91904.1 - 0.12 11.6 0.0 5.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Acetyltransf_5 PF13444.6 CRG91905.1 - 2.7e-07 31.2 0.0 4.8e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG91905.1 - 1.3e-06 28.7 0.1 2.5e-06 27.7 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG91905.1 - 1.7e-06 28.0 0.1 0.049 13.6 0.1 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 CRG91905.1 - 2.7e-05 24.2 0.0 0.0001 22.3 0.0 1.8 2 0 0 2 2 2 1 GCN5-related N-acetyl-transferase Acetyltransf_7 PF13508.7 CRG91905.1 - 5e-05 23.6 0.0 9.4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG91905.1 - 0.067 13.2 0.1 1.6 8.7 0.0 2.4 1 1 1 2 2 2 0 FR47-like protein FYVE PF01363.21 CRG91906.1 - 7.9e-15 54.7 8.9 1.4e-14 54.0 8.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 CRG91906.1 - 0.35 11.1 13.9 0.041 14.1 8.7 2.1 2 0 0 2 2 2 0 AN1-like Zinc finger RskA PF10099.9 CRG91906.1 - 1.7 8.9 15.1 0.15 12.4 10.1 1.9 2 1 0 2 2 2 0 Anti-sigma-K factor rskA Zn_clus PF00172.18 CRG91907.1 - 4.4e-05 23.5 5.5 0.0001 22.3 5.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_57 PF03065.15 CRG91907.1 - 0.0073 15.5 0.1 0.011 14.9 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 TPR_MalT PF17874.1 CRG91907.1 - 0.011 15.1 2.1 0.012 15.1 0.5 1.8 2 0 0 2 2 2 0 MalT-like TPR region UPF0697 PF15117.6 CRG91908.1 - 0.03 14.4 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0697 DUF2149 PF09919.9 CRG91908.1 - 0.051 13.8 0.0 0.064 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2149) FeoB_C PF07664.12 CRG91908.1 - 0.054 13.2 0.2 0.081 12.6 0.2 1.3 1 0 0 1 1 1 0 Ferrous iron transport protein B C terminus FtsL PF04999.13 CRG91908.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Cell division protein FtsL Cys_Met_Meta_PP PF01053.20 CRG91909.1 - 1.7e-61 207.9 0.0 4.3e-61 206.5 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 CRG91909.1 - 0.00047 19.4 0.0 0.00095 18.4 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 CRG91909.1 - 0.056 12.4 0.0 0.085 11.8 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG91909.1 - 0.18 11.1 0.0 0.4 9.9 0.0 1.6 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Tyrosinase PF00264.20 CRG91910.1 - 1.6e-21 77.6 4.0 2.6e-21 76.9 4.0 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase HD PF01966.22 CRG91911.1 - 4.4e-05 23.7 0.0 0.00013 22.2 0.0 2.0 1 1 0 1 1 1 1 HD domain Aegerolysin PF06355.13 CRG91912.1 - 1.7e-30 105.7 0.5 4.8e-29 101.1 0.1 2.0 1 1 1 2 2 2 2 Aegerolysin Isochorismatase PF00857.20 CRG91914.1 - 1.4e-21 77.4 0.0 1.6e-21 77.2 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family DUF563 PF04577.14 CRG91914.1 - 0.1 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF563) TraT PF05818.12 CRG91914.1 - 0.11 12.2 0.1 0.25 11.0 0.0 1.5 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein Peptidase_M6 PF05547.11 CRG91915.1 - 4.5e-28 98.0 8.7 2.7e-24 85.5 4.6 2.6 1 1 1 2 2 2 2 Immune inhibitor A peptidase M6 Methyltr_RsmB-F PF01189.17 CRG91916.1 - 9.3e-15 54.8 0.1 3.7e-08 33.3 0.1 2.7 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Peptidase_S41 PF03572.18 CRG91918.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S41 FA_hydroxylase PF04116.13 CRG91919.1 - 9.5e-23 81.0 17.4 9.5e-23 81.0 17.4 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily TCTP PF00838.17 CRG91920.1 - 6.6e-54 182.7 0.1 8.9e-54 182.3 0.1 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein DUF3627 PF12299.8 CRG91920.1 - 0.045 13.8 0.1 0.14 12.3 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3627) Sod_Fe_N PF00081.22 CRG91920.1 - 0.084 13.4 0.2 0.22 12.0 0.2 1.6 2 0 0 2 2 2 0 Iron/manganese superoxide dismutases, alpha-hairpin domain N_BRCA1_IG PF16158.5 CRG91920.1 - 0.1 13.4 0.0 0.5 11.1 0.0 1.9 1 1 1 2 2 2 0 Ig-like domain from next to BRCA1 gene Fungal_trans PF04082.18 CRG91921.1 - 5e-15 55.3 0.0 9e-15 54.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91921.1 - 1.5e-10 41.0 11.3 2.4e-10 40.4 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YvrJ PF12841.7 CRG91921.1 - 0.14 11.7 0.1 0.33 10.5 0.1 1.7 1 0 0 1 1 1 0 YvrJ protein family Lipase_3 PF01764.25 CRG91922.1 - 6.4e-16 58.5 0.0 1.3e-15 57.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) DJ-1_PfpI PF01965.24 CRG91922.1 - 6.3e-09 35.9 0.0 9.6e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Fungal_trans PF04082.18 CRG91924.1 - 2.9e-23 82.3 1.8 5e-23 81.5 1.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Amidohydro_1 PF01979.20 CRG91924.1 - 1.9e-09 37.3 0.0 6.8e-09 35.5 0.0 2.0 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG91924.1 - 0.0062 16.1 3.8 0.0064 16.0 0.8 2.0 1 1 0 2 2 2 1 Amidohydrolase family DUF2229 PF09989.9 CRG91924.1 - 0.039 13.6 0.0 3 7.4 0.0 2.3 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Zn_ribbon_2 PF12674.7 CRG91924.1 - 0.15 12.8 0.0 0.4 11.4 0.0 1.8 1 0 0 1 1 1 0 Putative zinc ribbon domain Transp_cyt_pur PF02133.15 CRG91925.1 - 1.3e-94 317.5 38.6 1.7e-94 317.1 38.6 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SRP19 PF01922.17 CRG91926.1 - 5.8e-32 110.5 0.0 8.1e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 SRP19 protein Aminotran_3 PF00202.21 CRG91927.1 - 1.2e-88 297.6 0.0 1.4e-88 297.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III CPSF73-100_C PF11718.8 CRG91928.1 - 1.6e-77 260.0 0.0 2.3e-77 259.4 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 CRG91928.1 - 5.7e-30 103.8 0.0 1.4e-29 102.6 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 CRG91928.1 - 2e-21 76.9 0.7 3.8e-21 76.0 0.4 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 CRG91928.1 - 2.9e-16 59.5 0.1 5.1e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 CRG91928.1 - 6.8e-12 45.1 0.0 1.7e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 CRG91928.1 - 0.00025 21.0 0.1 0.00098 19.1 0.1 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 CRG91928.1 - 0.0004 20.0 0.2 0.0011 18.5 0.2 1.8 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TAF4 PF05236.14 CRG91929.1 - 8.1e-34 117.6 1.1 1.7e-24 87.1 3.3 2.1 2 0 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family Pkinase PF00069.25 CRG91930.1 - 8.8e-50 169.5 0.0 1.4e-49 168.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG91930.1 - 6.7e-20 71.5 0.0 2.8e-19 69.4 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CRG91930.1 - 0.089 12.1 0.0 0.35 10.2 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1857 PF08982.11 CRG91931.1 - 3.4e-38 130.8 0.1 3.8e-38 130.6 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1857) Lin0512_fam PF09585.10 CRG91931.1 - 0.08 13.0 0.0 0.18 11.9 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein (Lin0512_fam) Mtc PF03820.17 CRG91932.1 - 1.4e-115 385.7 0.0 1.6e-115 385.5 0.0 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier AAL_decarboxy PF03306.13 CRG91933.1 - 2.8e-69 232.8 0.1 3.1e-69 232.6 0.1 1.0 1 0 0 1 1 1 1 Alpha-acetolactate decarboxylase TPP_enzyme_N PF02776.18 CRG91934.1 - 1e-45 155.5 0.9 2.1e-45 154.4 0.9 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 CRG91934.1 - 9.4e-38 129.4 1.0 6.9e-37 126.6 0.1 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 CRG91934.1 - 6.7e-23 80.9 0.0 1.4e-22 79.9 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain PHD PF00628.29 CRG91935.1 - 7.4e-07 29.0 10.5 1.2e-06 28.3 10.5 1.3 1 0 0 1 1 1 1 PHD-finger zf-CSL PF05207.13 CRG91935.1 - 0.22 11.3 0.9 0.4 10.4 0.9 1.4 1 0 0 1 1 1 0 CSL zinc finger PHD_2 PF13831.6 CRG91935.1 - 5.4 6.7 9.5 8.9 6.0 9.5 1.3 1 0 0 1 1 1 0 PHD-finger DEAD PF00270.29 CRG91936.1 - 0.00031 20.6 0.0 0.00048 19.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ank_2 PF12796.7 CRG91937.1 - 1.8e-101 332.9 22.7 1.1e-14 54.8 0.1 7.2 1 1 8 9 9 9 9 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG91937.1 - 3e-60 199.9 4.0 2e-09 37.8 0.1 9.4 2 1 5 9 9 9 9 Ankyrin repeats (many copies) Ank PF00023.30 CRG91937.1 - 8.9e-48 158.7 15.4 0.0023 18.3 0.1 13.8 13 0 0 13 13 13 11 Ankyrin repeat Ank_3 PF13606.6 CRG91937.1 - 1.9e-36 119.9 3.7 0.27 11.9 0.0 13.3 12 0 0 12 12 12 9 Ankyrin repeat Ank_5 PF13857.6 CRG91937.1 - 2e-30 104.4 3.0 0.0068 16.7 0.0 10.1 2 2 7 10 10 10 10 Ankyrin repeats (many copies) NACHT PF05729.12 CRG91937.1 - 6.2e-08 32.7 0.1 1.8e-07 31.2 0.1 1.8 1 0 0 1 1 1 1 NACHT domain PNP_UDP_1 PF01048.20 CRG91937.1 - 6.2e-08 32.2 0.7 3e-07 29.9 0.7 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily AAA_16 PF13191.6 CRG91937.1 - 5e-05 23.8 0.8 0.00042 20.7 0.1 2.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CRG91937.1 - 0.00023 21.4 0.2 0.00086 19.6 0.0 2.1 2 0 0 2 2 1 1 AAA domain ATPase_2 PF01637.18 CRG91937.1 - 0.028 14.4 0.0 0.056 13.3 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 CRG91937.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 CRG91937.1 - 0.14 11.3 0.1 0.6 9.2 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain DUF3435 PF11917.8 CRG91938.1 - 7e-129 430.4 1.2 7e-129 430.4 1.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) SVM_signal PF12113.8 CRG91938.1 - 0.24 11.3 1.4 0.54 10.2 1.4 1.5 1 0 0 1 1 1 0 SVM protein signal sequence EHN PF06441.12 CRG91939.1 - 4.2e-32 110.7 1.7 1.5e-31 108.9 0.1 2.1 2 0 0 2 2 2 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG91939.1 - 9.2e-09 35.3 0.1 1.5e-08 34.6 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG91939.1 - 0.079 13.5 0.2 0.34 11.5 0.1 2.0 2 0 0 2 2 2 0 Alpha/beta hydrolase family Acetyltransf_10 PF13673.7 CRG91940.1 - 2e-11 44.0 0.0 3.8e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG91940.1 - 3.6e-09 36.9 0.0 5.2e-09 36.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG91940.1 - 6.7e-07 29.7 0.0 1.3e-06 28.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 CRG91940.1 - 0.0018 18.2 0.0 0.0031 17.4 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 CRG91940.1 - 0.084 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase MFS_1 PF07690.16 CRG91941.1 - 1.5e-48 165.5 23.9 1.5e-48 165.5 23.9 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91941.1 - 2e-16 59.9 2.1 2e-16 59.9 2.1 3.0 3 0 0 3 3 3 1 Sugar (and other) transporter DUF4079 PF13301.6 CRG91941.1 - 0.035 14.3 0.0 3.2 7.9 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) MFS_1_like PF12832.7 CRG91941.1 - 0.088 11.6 12.2 0.0066 15.4 6.1 2.1 2 2 0 2 2 2 0 MFS_1 like family NmrA PF05368.13 CRG91944.1 - 6e-16 58.7 0.1 1e-15 57.9 0.1 1.4 1 1 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG91944.1 - 1.2e-13 51.4 0.1 3.1e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 CRG91944.1 - 1.8e-07 31.5 0.1 4.1e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 CRG91944.1 - 5.3e-05 22.8 0.1 7.6e-05 22.3 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 CRG91944.1 - 0.00058 20.3 0.2 0.001 19.5 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 CRG91944.1 - 0.00098 19.2 0.8 0.0023 18.1 0.7 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.22 CRG91944.1 - 0.0044 17.8 0.2 0.0079 17.0 0.2 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold 3Beta_HSD PF01073.19 CRG91944.1 - 0.006 15.6 0.0 0.016 14.2 0.0 1.7 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family ApbA PF02558.16 CRG91944.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA KR PF08659.10 CRG91944.1 - 0.14 12.1 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 KR domain HTH_9 PF08221.11 CRG91944.1 - 0.16 12.1 0.0 0.42 10.8 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Zn_clus PF00172.18 CRG91945.1 - 5.6e-09 36.0 9.4 5.6e-09 36.0 9.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG91945.1 - 3.2e-05 23.1 0.0 5.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DNA_pack_C PF02499.15 CRG91945.1 - 0.16 10.9 0.1 0.24 10.3 0.1 1.2 1 0 0 1 1 1 0 Probable DNA packing protein, C-terminus Glyco_hydro_28 PF00295.17 CRG91946.1 - 1.9e-107 359.1 17.9 2.3e-107 358.9 17.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 DUF2180 PF09947.9 CRG91946.1 - 0.068 13.1 1.2 0.14 12.2 1.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) Aa_trans PF01490.18 CRG91947.1 - 1.3e-32 113.0 22.1 2.1e-22 79.4 10.1 2.1 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein Fungal_trans PF04082.18 CRG91947.1 - 6.9e-12 45.0 0.2 1.4e-11 43.9 0.2 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1430 PF07242.11 CRG91947.1 - 4.8 7.5 5.6 19 5.6 3.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) DHDPS PF00701.22 CRG91948.1 - 1.1e-39 135.9 0.1 1.4e-39 135.5 0.1 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family TPR_10 PF13374.6 CRG91948.1 - 0.091 12.7 1.7 0.43 10.5 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NRBF2_MIT PF17169.4 CRG91948.1 - 1.1 9.6 3.1 2.1 8.6 0.2 2.7 2 2 1 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 P5CR_dimer PF14748.6 CRG91949.1 - 1.3e-28 99.3 4.1 4.2e-28 97.6 2.8 2.4 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation Pro_dh PF01619.18 CRG91949.1 - 1.3e-22 80.7 0.0 1.9e-22 80.2 0.0 1.2 1 0 0 1 1 1 1 Proline dehydrogenase F420_oxidored PF03807.17 CRG91949.1 - 2.8e-09 37.4 0.2 6.1e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AP_endonuc_2 PF01261.24 CRG91949.1 - 0.063 12.7 0.0 0.32 10.4 0.0 2.1 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel GHMP_kinases_C PF08544.13 CRG91949.1 - 0.12 12.8 0.0 0.36 11.2 0.0 1.8 1 0 0 1 1 1 0 GHMP kinases C terminal Aldedh PF00171.22 CRG91950.1 - 2.9e-96 322.8 0.0 3.8e-96 322.4 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DAO PF01266.24 CRG91951.1 - 2e-35 123.0 0.0 2.5e-35 122.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG91951.1 - 4.1e-06 26.9 0.0 1.6e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG91951.1 - 0.0002 20.2 0.1 0.47 9.1 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 CRG91951.1 - 0.00023 20.5 0.0 0.1 11.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG91951.1 - 0.0018 18.3 0.0 0.039 14.0 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG91951.1 - 0.003 16.9 0.1 0.039 13.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG91951.1 - 0.0091 15.3 0.0 0.05 12.8 0.0 2.0 2 0 0 2 2 2 1 Thi4 family Amino_oxidase PF01593.24 CRG91951.1 - 0.03 13.6 0.0 0.57 9.4 0.0 2.1 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase GIDA PF01134.22 CRG91951.1 - 0.034 13.2 0.0 3.9 6.4 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CRG91951.1 - 0.039 13.0 0.1 0.13 11.3 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain NAD_binding_7 PF13241.6 CRG91951.1 - 0.071 13.6 0.0 0.28 11.6 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 CRG91951.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 CRG91951.1 - 0.15 12.3 0.0 0.55 10.5 0.0 2.0 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.21 CRG91951.1 - 0.17 11.2 0.0 0.43 9.9 0.0 1.6 2 0 0 2 2 2 0 ThiF family DUF4646 PF15496.6 CRG91952.1 - 0.064 13.9 0.0 0.088 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4646) Erf4 PF10256.9 CRG91952.1 - 0.075 13.1 0.0 0.19 11.8 0.0 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Abhydrolase_6 PF12697.7 CRG91953.1 - 0.0027 18.4 1.7 0.004 17.8 1.3 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 CRG91953.1 - 0.003 17.1 0.0 0.056 13.0 0.0 2.4 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 CRG91953.1 - 0.022 14.0 0.0 0.043 13.1 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 CRG91953.1 - 0.072 12.5 0.0 0.36 10.3 0.0 1.9 1 1 1 2 2 2 0 Prolyl oligopeptidase family DUF1100 PF06500.11 CRG91953.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) Epimerase PF01370.21 CRG91954.1 - 3.8e-16 59.3 0.1 1.8e-15 57.0 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG91954.1 - 3.4e-08 33.3 0.0 1.3e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 CRG91954.1 - 8.4e-08 32.3 0.0 1.3e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 CRG91954.1 - 2.9e-07 30.3 0.0 4.6e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family 3Beta_HSD PF01073.19 CRG91954.1 - 2.4e-06 26.8 0.0 4.2e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 CRG91954.1 - 5.4e-06 25.8 0.0 0.01 15.0 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 CRG91954.1 - 0.027 13.6 0.1 0.2 10.8 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein MFS_1 PF07690.16 CRG91955.1 - 1.2e-38 132.9 23.7 1.7e-38 132.5 23.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91955.1 - 5.9e-14 51.8 6.4 5.9e-14 51.8 6.4 1.9 1 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG91955.1 - 0.00046 18.8 2.2 0.00072 18.1 2.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) CBM_1 PF00734.18 CRG91956.1 - 4.5e-13 48.9 6.9 4.5e-13 48.9 6.9 3.1 2 1 0 2 2 2 1 Fungal cellulose binding domain DPBB_1 PF03330.18 CRG91956.1 - 1.2e-06 28.7 0.4 1.2e-06 28.7 0.4 2.2 2 0 0 2 2 2 1 Lytic transglycolase MFS_1 PF07690.16 CRG91957.1 - 4.6e-40 137.6 54.3 1.4e-39 136.0 54.3 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG91957.1 - 6.9e-12 44.6 25.4 9.2e-12 44.2 25.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) BNIP2 PF12496.8 CRG91957.1 - 0.08 13.4 0.8 0.13 12.7 0.8 1.2 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Sugar_tr PF00083.24 CRG91958.1 - 7.4e-96 321.7 22.4 9.4e-96 321.4 22.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG91958.1 - 7.5e-29 100.8 39.8 3.6e-23 82.1 14.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Amidohydro_1 PF01979.20 CRG91958.1 - 9.2e-16 58.1 0.0 1.4e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 CRG91958.1 - 3.1e-11 43.4 0.1 1.1e-08 35.0 0.0 2.4 2 0 0 2 2 2 2 Amidohydrolase family LOB PF03195.14 CRG91958.1 - 0.1 13.2 0.1 0.6 10.7 0.0 2.1 2 0 0 2 2 2 0 Lateral organ boundaries (LOB) domain MFS_1_like PF12832.7 CRG91958.1 - 1 8.2 16.1 0.034 13.0 4.7 3.1 2 1 0 2 2 2 0 MFS_1 like family Aldo_ket_red PF00248.21 CRG91959.1 - 3.9e-50 170.7 0.0 4.4e-50 170.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PhyH PF05721.13 CRG91960.1 - 2.4e-07 31.3 0.0 6.2e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 4HBT_3 PF13622.6 CRG91961.1 - 7.2e-41 141.1 0.0 8.6e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 CRG91961.1 - 0.0023 17.3 0.0 0.011 15.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-ACP thioesterase Geminin PF07412.12 CRG91961.1 - 0.036 13.8 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Geminin 4HBT PF03061.22 CRG91961.1 - 0.088 13.2 0.0 0.55 10.6 0.0 2.2 2 0 0 2 2 2 0 Thioesterase superfamily Phosphoesterase PF04185.14 CRG91962.1 - 3.3e-60 204.2 0.5 4.5e-60 203.7 0.5 1.2 1 0 0 1 1 1 1 Phosphoesterase family Aminotran_1_2 PF00155.21 CRG91963.1 - 3.9e-35 121.7 0.0 4.6e-35 121.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II LisH_TPL PF17814.1 CRG91963.1 - 0.094 12.4 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 LisH-like dimerisation domain Steroid_dh PF02544.16 CRG91963.1 - 0.1 12.6 0.0 0.25 11.3 0.0 1.6 1 1 1 2 2 2 0 3-oxo-5-alpha-steroid 4-dehydrogenase Glyco_hydro_76 PF03663.14 CRG91964.1 - 3.5e-38 132.1 21.6 4e-38 131.9 21.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_127 PF07944.12 CRG91964.1 - 0.0067 15.0 0.1 0.66 8.4 0.0 2.1 1 1 1 2 2 2 2 Beta-L-arabinofuranosidase, GH127 KR PF08659.10 CRG91965.1 - 3.6e-64 216.0 0.0 8.3e-64 214.8 0.0 1.6 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 CRG91965.1 - 1.5e-63 214.7 0.0 2.5e-63 214.0 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG91965.1 - 1.9e-59 201.4 0.2 3e-59 200.7 0.2 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CRG91965.1 - 1.8e-33 115.0 0.4 6.3e-33 113.3 0.2 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Acyl_transf_1 PF00698.21 CRG91965.1 - 7.8e-33 114.3 0.0 2.4e-30 106.1 0.0 3.2 1 1 1 2 2 2 1 Acyl transferase domain Methyltransf_12 PF08242.12 CRG91965.1 - 9.7e-22 77.6 0.0 4.6e-21 75.4 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CRG91965.1 - 8.7e-17 61.3 0.0 2.3e-16 60.0 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG91965.1 - 1.5e-16 61.7 0.0 8.7e-15 55.9 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 CRG91965.1 - 2e-16 60.4 0.2 1.4e-15 57.7 0.2 2.3 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 CRG91965.1 - 6.2e-14 52.2 0.0 1.6e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG91965.1 - 5.8e-10 39.2 0.0 1.8e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG91965.1 - 9.2e-10 39.1 0.1 6.2e-09 36.5 0.0 2.7 2 0 0 2 2 1 1 Methyltransferase domain adh_short PF00106.25 CRG91965.1 - 1e-09 38.2 0.0 2.3e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 short chain dehydrogenase Methyltransf_11 PF08241.12 CRG91965.1 - 1.8e-07 31.7 0.0 5.8e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG91965.1 - 3.1e-05 23.4 0.0 9.1e-05 21.9 0.0 1.7 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 CRG91965.1 - 0.00095 18.6 0.0 0.0019 17.6 0.0 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain SLS PF14611.6 CRG91965.1 - 0.0072 16.2 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Methyltransf_2 PF00891.18 CRG91965.1 - 0.0078 15.5 0.0 0.025 13.9 0.0 1.9 1 0 0 1 1 1 1 O-methyltransferase domain YjeF_N PF03853.15 CRG91965.1 - 0.0084 16.0 0.0 5.2 6.9 0.0 3.1 3 0 0 3 3 3 1 YjeF-related protein N-terminus NodS PF05401.11 CRG91965.1 - 0.016 14.8 0.0 0.037 13.7 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_16 PF10294.9 CRG91965.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Lysine methyltransferase DUF5134 PF17197.4 CRG91965.1 - 0.081 12.8 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5134) ADH_N PF08240.12 CRG91965.1 - 0.085 12.7 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Methyltransf_9 PF08003.11 CRG91965.1 - 0.15 11.0 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) FSH1 PF03959.13 CRG91966.1 - 1.6e-18 67.2 0.0 2e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) MFS_1 PF07690.16 CRG91968.1 - 1.5e-38 132.6 57.0 1.5e-32 113.0 32.1 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG91968.1 - 2.3e-11 43.3 8.3 2.3e-11 43.3 8.3 3.3 2 1 0 3 3 3 1 Sugar (and other) transporter MtrF PF09472.10 CRG91968.1 - 5.5 6.5 6.6 0.81 9.1 0.9 2.7 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Peptidase_S64 PF08192.11 CRG91969.1 - 9.6e-07 27.7 0.0 2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family S64 Peptidase_S32 PF05579.13 CRG91969.1 - 0.085 12.0 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 Equine arteritis virus serine endopeptidase S32 Glyco_trans_4_5 PF16994.5 CRG91969.1 - 0.1 12.2 0.2 0.33 10.5 0.1 1.8 2 0 0 2 2 2 0 Glycosyl-transferase family 4 Ank_5 PF13857.6 CRG91970.1 - 0.037 14.3 0.0 0.1 13.0 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG91970.1 - 0.064 13.9 0.2 0.51 11.0 0.1 2.5 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) AAA_22 PF13401.6 CRG91970.1 - 0.1 12.9 0.0 0.19 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 CRG91971.1 - 3.5e-46 157.2 0.1 3e-45 154.1 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG91971.1 - 4.3e-25 88.2 0.0 1.9e-24 86.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CRG91971.1 - 4.1e-19 68.6 0.2 8.1e-19 67.6 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CRG91971.1 - 3.7e-05 23.8 0.0 9.7e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 CRG91971.1 - 0.044 13.5 0.1 0.64 9.7 0.1 2.2 1 1 0 1 1 1 0 AAA domain ORC6 PF05460.13 CRG91972.1 - 0.01 15.2 0.2 0.018 14.4 0.2 1.4 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) adh_short_C2 PF13561.6 CRG91973.1 - 9e-54 182.5 6.8 3e-53 180.8 6.8 1.7 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG91973.1 - 1.3e-29 103.1 3.9 6.8e-29 100.7 3.9 1.8 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG91973.1 - 5.9e-06 26.3 1.5 7.6e-06 26.0 0.3 1.8 2 0 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 CRG91973.1 - 0.039 13.8 0.2 0.074 12.9 0.2 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YjeF_N PF03853.15 CRG91973.1 - 0.063 13.2 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 YjeF-related protein N-terminus WD40 PF00400.32 CRG91974.1 - 1.4e-30 104.8 29.8 2.1e-07 31.5 0.2 7.3 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG91974.1 - 3e-17 62.7 2.1 0.00047 20.4 0.0 4.9 2 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 CRG91974.1 - 2.3e-08 33.7 0.4 0.0019 17.6 0.0 2.6 2 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 CRG91974.1 - 5.9e-07 28.5 2.3 0.0015 17.3 0.3 3.1 2 2 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 CRG91974.1 - 0.00054 18.8 2.7 0.27 9.9 0.9 2.9 1 1 0 2 2 2 2 Nup133 N terminal like eIF2A PF08662.11 CRG91974.1 - 0.012 15.5 0.0 1.5 8.6 0.0 3.0 2 2 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 CRG91974.1 - 0.026 13.9 1.0 1.9 7.8 0.0 3.7 2 2 3 5 5 5 0 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 CRG91974.1 - 0.029 13.3 0.4 3.2 6.6 0.0 3.2 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 CRG91974.1 - 0.075 13.4 6.3 2.8 8.4 0.1 5.0 4 2 1 5 5 5 0 Kelch motif PQQ_3 PF13570.6 CRG91974.1 - 0.082 13.4 13.5 7.4 7.2 0.5 6.3 7 0 0 7 7 7 0 PQQ-like domain PALB2_WD40 PF16756.5 CRG91974.1 - 0.14 11.1 4.9 1.4 7.8 0.2 3.5 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain RCC1_2 PF13540.6 CRG91974.1 - 2.8 7.8 8.0 2.2 8.2 0.1 4.1 5 0 0 5 5 5 0 Regulator of chromosome condensation (RCC1) repeat Glyco_tranf_2_3 PF13641.6 CRG91975.1 - 1.9e-19 70.5 0.0 3.5e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 CRG91975.1 - 1.2e-17 64.5 0.5 1.2e-17 64.5 0.5 2.8 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Cellulose_synt PF03552.14 CRG91975.1 - 1e-13 50.7 0.1 2.9e-08 32.7 0.1 2.9 1 1 2 3 3 3 2 Cellulose synthase Glycos_transf_2 PF00535.26 CRG91975.1 - 2.3e-13 50.3 0.0 4e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 CRG91975.1 - 3.9e-11 42.7 0.0 6.7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 CRG91975.1 - 0.042 12.5 0.1 0.096 11.3 0.0 1.6 2 0 0 2 2 2 0 Chitin synthase Glyco_hydro_12 PF01670.16 CRG91976.1 - 3.5e-23 82.7 7.3 3.8e-22 79.3 7.3 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 ABC_membrane PF00664.23 CRG91977.1 - 1e-94 317.3 36.6 1.4e-50 172.5 14.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 CRG91977.1 - 8.3e-69 230.4 0.0 1.8e-33 116.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 CRG91977.1 - 2e-13 50.3 3.2 0.00014 21.4 0.1 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG91977.1 - 8.4e-08 31.8 0.1 0.0015 18.2 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG91977.1 - 9.2e-08 32.2 0.0 0.0036 17.2 0.0 3.3 3 0 0 3 3 3 2 RsgA GTPase AAA_15 PF13175.6 CRG91977.1 - 4.1e-07 30.1 0.0 0.00061 19.6 0.0 2.5 3 0 0 3 3 2 2 AAA ATPase domain AAA_16 PF13191.6 CRG91977.1 - 6.2e-07 30.0 2.5 0.048 14.1 0.1 3.3 2 2 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 CRG91977.1 - 7.6e-06 25.0 3.7 0.027 13.3 0.0 2.7 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA PF00004.29 CRG91977.1 - 5.2e-05 23.7 1.9 8 6.9 0.4 4.5 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 CRG91977.1 - 9.2e-05 22.4 0.6 0.44 10.3 0.1 4.1 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 CRG91977.1 - 0.0001 22.5 1.9 0.48 10.7 0.2 3.6 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 CRG91977.1 - 0.00019 22.0 1.0 0.17 12.4 0.1 3.6 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 CRG91977.1 - 0.00022 21.0 0.9 0.49 10.1 0.0 3.6 4 0 0 4 4 4 1 AAA domain AAA_22 PF13401.6 CRG91977.1 - 0.0007 19.9 3.5 0.23 11.7 0.1 3.7 2 2 0 2 2 2 1 AAA domain AAA_25 PF13481.6 CRG91977.1 - 0.002 17.8 0.1 1.7 8.2 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 CRG91977.1 - 0.0021 17.6 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 CRG91977.1 - 0.0021 18.2 0.0 1.9 8.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 CRG91977.1 - 0.0023 17.3 0.0 0.53 9.5 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin G-alpha PF00503.20 CRG91977.1 - 0.0034 16.6 0.0 0.53 9.4 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_5 PF07728.14 CRG91977.1 - 0.0086 16.1 0.3 15 5.6 0.0 3.9 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CRG91977.1 - 0.0093 16.5 0.0 5.2 7.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 CRG91977.1 - 0.013 15.8 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 CRG91977.1 - 0.031 14.2 0.2 2 8.3 0.0 2.9 3 0 0 3 3 3 0 Rad17 P-loop domain DUF815 PF05673.13 CRG91977.1 - 0.042 13.0 0.0 0.73 8.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 CRG91977.1 - 0.046 13.8 0.2 23 5.1 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 CRG91977.1 - 0.1 13.0 0.0 18 5.7 0.0 2.8 2 0 0 2 2 2 0 RNA helicase DUF4133 PF13571.6 CRG91977.1 - 6.8 7.1 9.4 36 4.8 2.0 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) ADH_zinc_N_2 PF13602.6 CRG91978.1 - 7.9e-17 62.6 0.0 1.3e-16 61.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG91978.1 - 6e-12 45.7 0.1 1.1e-11 44.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG91978.1 - 9.9e-05 22.2 0.0 0.00022 21.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Semialdhyde_dh PF01118.24 CRG91978.1 - 0.0078 16.7 0.1 0.023 15.1 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 CRG91978.1 - 0.15 11.5 0.1 0.23 10.9 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Fungal_trans PF04082.18 CRG91979.1 - 7e-10 38.4 0.1 1.3e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG91979.1 - 2.5e-09 37.1 7.4 4.8e-09 36.2 7.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_A4 PF01828.17 CRG91980.1 - 8.4e-70 234.5 19.6 1.1e-69 234.2 19.6 1.1 1 0 0 1 1 1 1 Peptidase A4 family MFS_1 PF07690.16 CRG91981.1 - 8.5e-41 140.0 19.5 1.4e-27 96.5 0.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG91981.1 - 1.8e-07 29.8 0.6 1.8e-07 29.8 0.6 2.2 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family ALMS_repeat PF18727.1 CRG91981.1 - 0.16 11.9 0.2 0.33 10.9 0.2 1.5 1 0 0 1 1 1 0 Alstrom syndrome repeat BT1 PF03092.16 CRG91981.1 - 6.8 4.8 9.3 1.1 7.4 0.2 2.9 3 1 0 3 3 3 0 BT1 family Mito_carr PF00153.27 CRG91982.1 - 3.5e-40 135.8 7.9 2.8e-15 56.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein p450 PF00067.22 CRG91983.1 - 2.6e-61 207.8 0.0 3.6e-61 207.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 UbiA PF01040.18 CRG91984.1 - 5.9e-21 74.9 13.8 9.1e-21 74.3 13.8 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family adh_short PF00106.25 CRG91985.1 - 2.2e-37 128.5 0.0 3.2e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91985.1 - 3.1e-28 98.9 0.0 4.2e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91985.1 - 1.1e-12 48.2 0.0 1.7e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG91985.1 - 0.0006 19.3 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CRG91985.1 - 0.0016 17.9 0.0 0.0022 17.4 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_4 PF07993.12 CRG91985.1 - 0.0019 17.4 0.0 0.0048 16.1 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 CRG91985.1 - 0.0049 16.4 0.3 0.0073 15.9 0.1 1.4 2 0 0 2 2 2 1 NmrA-like family DUF3493 PF11998.8 CRG91986.1 - 0.39 10.9 2.5 0.47 10.6 0.1 2.4 3 0 0 3 3 3 0 Low psii accumulation1 / Rep27 p450 PF00067.22 CRG91987.1 - 2.3e-46 158.5 0.0 3.4e-46 158.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FMO-like PF00743.19 CRG91988.1 - 8.3e-15 54.2 0.7 5.2e-14 51.6 0.1 2.3 2 1 0 2 2 2 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 CRG91988.1 - 3.2e-10 40.1 0.0 8.5e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG91988.1 - 4.1e-07 29.5 0.0 9.7e-05 21.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG91988.1 - 2e-06 27.2 0.1 0.46 9.6 0.0 4.1 4 0 0 4 4 4 3 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG91988.1 - 1.4e-05 24.5 0.0 9.6e-05 21.8 0.0 2.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG91988.1 - 0.00011 22.3 0.0 0.014 15.4 0.0 3.3 2 1 1 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CRG91988.1 - 0.0038 16.9 0.0 0.14 11.7 0.0 2.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 CRG91988.1 - 0.025 13.8 0.0 0.071 12.3 0.0 1.7 2 0 0 2 2 2 0 Thi4 family Condensation PF00668.20 CRG91989.1 - 0.0026 16.5 0.6 0.71 8.5 0.1 2.6 3 0 0 3 3 3 2 Condensation domain Rhodanese PF00581.20 CRG91990.1 - 6.8e-19 68.4 0.0 2.6e-10 40.7 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain A2M PF00207.22 CRG91991.1 - 0.15 12.0 0.2 5.9 6.8 0.0 3.3 3 1 1 4 4 4 0 Alpha-2-macroglobulin family EHN PF06441.12 CRG91992.1 - 1.9e-28 98.9 0.1 1.9e-28 98.9 0.1 2.4 2 1 1 3 3 3 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG91992.1 - 1.4e-16 60.9 0.1 3e-16 59.9 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG91992.1 - 1.1e-09 39.3 1.0 1.1e-09 39.3 1.0 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG91992.1 - 0.089 12.0 0.0 0.19 11.0 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 YkuD PF03734.14 CRG91992.1 - 0.96 9.9 2.9 17 5.8 0.1 2.6 2 1 1 3 3 3 0 L,D-transpeptidase catalytic domain adh_short PF00106.25 CRG91994.1 - 7e-23 81.1 0.0 7.2e-16 58.2 0.0 2.4 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91994.1 - 1.4e-12 47.7 0.0 7.1e-08 32.3 0.0 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91994.1 - 0.00054 19.9 0.0 0.00097 19.1 0.0 1.4 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CRG91995.1 - 1.3e-22 80.2 2.2 1.8e-22 79.8 2.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG91995.1 - 1.9e-19 70.1 0.5 2.6e-19 69.7 0.5 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG91995.1 - 3.4e-11 43.4 0.7 4.8e-11 42.9 0.7 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG91995.1 - 6.9e-05 22.4 0.2 0.00016 21.2 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 CRG91995.1 - 0.0034 16.7 0.2 0.0099 15.2 0.0 1.8 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 CRG91995.1 - 0.023 14.8 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 CRG91995.1 - 0.049 13.5 0.1 0.089 12.7 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG91995.1 - 0.14 11.2 0.1 0.89 8.6 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF3176 PF11374.8 CRG91996.1 - 2.2e-10 40.7 13.6 2.2e-10 40.7 13.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3176) SH3_3 PF08239.11 CRG91997.1 - 0.0047 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Fungal_trans PF04082.18 CRG91999.1 - 7.2e-05 21.9 0.0 0.00012 21.3 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4299 PF14132.6 CRG91999.1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) MFS_1 PF07690.16 CRG92000.1 - 2.2e-39 135.4 18.9 4.1e-35 121.3 10.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92000.1 - 1.1e-06 27.8 6.9 1.1e-06 27.8 6.9 3.0 3 0 0 3 3 3 1 Sugar (and other) transporter p450 PF00067.22 CRG92002.1 - 4.3e-62 210.4 0.0 5.4e-62 210.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NmrA PF05368.13 CRG92003.1 - 2.9e-59 200.4 0.3 3.6e-59 200.2 0.3 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 CRG92003.1 - 1.2e-11 44.8 0.0 1.7e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 CRG92003.1 - 0.00096 18.2 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 CRG92003.1 - 0.042 14.1 0.1 0.085 13.1 0.1 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 CRG92003.1 - 0.074 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Glyco_hydro_28 PF00295.17 CRG92004.1 - 8e-54 182.9 13.4 1.1e-53 182.5 13.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectinesterase PF01095.19 CRG92005.1 - 8.2e-52 175.8 4.8 1.1e-51 175.4 4.8 1.0 1 0 0 1 1 1 1 Pectinesterase Pectate_lyase_3 PF12708.7 CRG92005.1 - 0.0028 17.5 7.3 0.004 17.0 7.3 1.2 1 0 0 1 1 1 1 Pectate lyase superfamily protein DUF4402 PF14352.6 CRG92005.1 - 0.016 15.8 5.6 0.034 14.8 5.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4402) CwfJ_C_1 PF04677.15 CRG92005.1 - 0.067 13.1 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 APH PF01636.23 CRG92006.1 - 7.1e-18 65.4 0.0 1e-17 64.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Ntox28 PF15605.6 CRG92006.1 - 0.071 13.4 0.2 1 9.6 0.1 2.4 2 1 0 2 2 2 0 Bacterial toxin 28 HSP20 PF00011.21 CRG92008.1 - 0.0065 16.6 0.0 0.0095 16.1 0.0 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family Peptidase_S64 PF08192.11 CRG92009.1 - 0.0006 18.5 0.0 0.0023 16.5 0.0 1.9 2 0 0 2 2 2 1 Peptidase family S64 NPV_P10 PF05531.12 CRG92009.1 - 0.16 12.5 0.0 0.45 11.0 0.0 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4404 PF14357.6 CRG92010.1 - 0.075 13.7 0.1 2.3 8.9 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) MFS_1 PF07690.16 CRG92011.1 - 1e-31 110.2 29.1 1.3e-31 109.8 29.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily p450 PF00067.22 CRG92012.1 - 5.6e-53 180.3 0.0 1.4e-42 146.0 0.0 2.3 2 0 0 2 2 2 2 Cytochrome P450 Fungal_trans PF04082.18 CRG92012.1 - 7.7e-09 35.0 0.0 1.7e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M19 PF01244.21 CRG92013.1 - 1e-103 346.9 0.0 1.2e-103 346.6 0.0 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) MFS_1 PF07690.16 CRG92014.1 - 1.5e-12 47.1 35.1 5.2e-09 35.5 4.8 3.1 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF5504 PF17608.2 CRG92014.1 - 1.1 9.4 5.9 15 5.7 5.9 2.5 1 1 0 1 1 1 0 Family of unknown function (DUF5504) Fungal_trans PF04082.18 CRG92015.1 - 9.9e-08 31.3 1.1 1.5e-07 30.7 1.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 CRG92016.1 - 8.8e-18 64.7 0.2 2.5e-17 63.2 0.2 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 CRG92016.1 - 1.6e-08 34.6 0.9 0.00052 19.7 0.9 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG92016.1 - 2.4e-07 30.3 1.7 0.0011 18.2 0.3 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG92016.1 - 5.8e-07 28.7 0.3 0.002 17.0 0.2 3.0 3 0 0 3 3 3 2 Tryptophan halogenase NAD_binding_8 PF13450.6 CRG92016.1 - 0.00013 22.1 0.3 0.00036 20.7 0.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG92016.1 - 0.00038 19.7 0.2 0.00066 18.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 CRG92016.1 - 0.00066 19.0 0.2 0.0019 17.6 0.1 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 CRG92016.1 - 0.00068 20.2 0.1 0.0044 17.5 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 CRG92016.1 - 0.0027 16.5 0.2 0.014 14.1 0.2 1.9 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 CRG92016.1 - 0.016 14.3 0.6 0.03 13.4 0.6 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 CRG92016.1 - 0.055 12.7 0.6 0.1 11.9 0.6 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG92016.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 CRG92016.1 - 0.18 11.8 0.3 0.63 10.0 0.3 1.9 1 1 0 1 1 1 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG92016.1 - 0.24 10.4 0.7 0.46 9.5 0.2 1.7 2 1 0 2 2 2 0 Lycopene cyclase protein PhyH PF05721.13 CRG92017.1 - 3e-06 27.6 0.2 2.2e-05 24.8 0.2 2.1 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 CRG92017.1 - 4.7e-06 25.6 0.0 0.14 10.9 0.2 3.0 3 0 0 3 3 3 3 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 CRG92017.1 - 0.063 13.7 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase ketoacyl-synt PF00109.26 CRG92018.1 - 1.3e-72 244.5 0.4 4.2e-72 242.8 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 CRG92018.1 - 2.7e-32 111.3 3.2 4.1e-32 110.7 1.8 2.2 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain HTH_51 PF18558.1 CRG92018.1 - 1.3e-28 98.7 0.0 5.8e-28 96.6 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Acyl_transf_1 PF00698.21 CRG92018.1 - 3e-18 66.4 0.0 2.8e-16 59.9 0.0 2.4 2 0 0 2 2 2 1 Acyl transferase domain PP-binding PF00550.25 CRG92018.1 - 3.4e-14 52.9 0.3 3e-13 49.9 0.3 2.4 2 0 0 2 2 2 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 CRG92018.1 - 6.7e-14 52.4 0.0 2e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain PS-DH PF14765.6 CRG92018.1 - 5.2e-12 45.6 0.0 9.6e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase SAT PF16073.5 CRG92018.1 - 1.5e-10 41.2 10.8 2e-09 37.5 2.2 3.7 3 2 0 3 3 3 2 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_23 PF13489.6 CRG92018.1 - 3.4e-10 40.0 0.0 1.1e-09 38.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92018.1 - 2.4e-09 37.8 0.0 9.5e-09 35.9 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG92018.1 - 1.4e-08 35.2 0.0 4e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Thiolase_N PF00108.23 CRG92018.1 - 4e-07 29.7 1.5 2.4e-06 27.1 0.1 2.3 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 CRG92018.1 - 1.1e-06 29.2 0.0 1.5e-05 25.6 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92018.1 - 6.2e-06 26.1 0.0 1.6e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain ACP_syn_III PF08545.10 CRG92018.1 - 0.0025 17.6 1.8 0.0067 16.3 0.3 2.4 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_28 PF02636.17 CRG92018.1 - 0.054 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_33 PF10017.9 CRG92018.1 - 0.12 11.5 0.0 0.86 8.7 0.0 2.3 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent FSH1 PF03959.13 CRG92019.1 - 1.1e-26 93.8 0.0 1.4e-26 93.5 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 CRG92019.1 - 0.00039 20.3 0.1 0.00054 19.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 CRG92019.1 - 0.0066 16.3 0.0 0.064 13.0 0.0 2.2 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 CRG92019.1 - 0.09 12.0 0.0 10 5.3 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 PE-PPE PF08237.11 CRG92019.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain Vps55 PF04133.14 CRG92020.1 - 0.071 13.1 0.4 0.071 13.1 0.4 2.6 3 1 0 3 3 3 0 Vacuolar protein sorting 55 Lactamase_B_2 PF12706.7 CRG92021.1 - 2.2e-30 105.7 0.1 3.5e-28 98.5 0.1 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 CRG92021.1 - 6.5e-10 39.1 0.0 3.9e-09 36.6 0.0 2.1 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 CRG92021.1 - 0.0095 16.0 4.4 1.4 8.9 3.0 2.8 2 1 0 2 2 2 2 Metallo-beta-lactamase superfamily GDPD PF03009.17 CRG92022.1 - 5.2e-32 111.6 0.0 1.8e-31 109.9 0.0 1.9 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 CRG92022.1 - 7.2e-05 23.1 0.2 0.0013 19.2 0.2 2.3 2 0 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family SLATT_fungal PF18142.1 CRG92023.1 - 1.8e-27 95.7 0.0 2.4e-27 95.3 0.0 1.2 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain Pex14_N PF04695.13 CRG92023.1 - 0.64 10.7 6.6 0.34 11.6 4.1 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MFS_1 PF07690.16 CRG92024.1 - 9.9e-25 87.2 41.5 9.9e-25 87.2 41.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 CRG92025.1 - 5.4e-23 81.5 0.1 5.1e-21 75.0 0.1 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92025.1 - 6.8e-12 45.4 0.1 2.8e-07 30.3 0.0 2.8 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92025.1 - 2.8e-07 30.6 0.0 4.3e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG92025.1 - 0.00082 18.9 0.1 0.73 9.3 0.0 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG92025.1 - 0.003 17.0 0.0 1.1 8.6 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Csm1_B PF18211.1 CRG92025.1 - 0.11 12.4 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Csm1 subunit domain B NAD_binding_7 PF13241.6 CRG92025.1 - 0.11 12.9 0.3 0.18 12.2 0.3 1.2 1 0 0 1 1 1 0 Putative NAD(P)-binding Fungal_trans PF04082.18 CRG92026.1 - 1.7e-05 24.0 0.1 3.8e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Glyco_hydro_17 PF00332.18 CRG92027.1 - 5.4e-07 29.5 0.6 2e-06 27.6 0.5 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 17 HVSL PF09749.9 CRG92028.1 - 4e-83 278.5 0.0 4.6e-83 278.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein Pal1 PF08316.11 CRG92029.1 - 6.1e-10 40.0 1.2 1.2e-09 39.1 0.1 2.0 2 0 0 2 2 2 1 Pal1 cell morphology protein Acyl_transf_3 PF01757.22 CRG92030.1 - 1.1e-25 90.4 18.8 2.8e-25 89.1 18.8 1.7 1 1 0 1 1 1 1 Acyltransferase family DUF1624 PF07786.12 CRG92030.1 - 4.7e-06 26.3 2.2 0.00062 19.4 0.3 3.4 2 1 1 3 3 3 2 Protein of unknown function (DUF1624) Caps_synth_CapC PF14102.6 CRG92030.1 - 0.019 15.4 0.2 0.069 13.6 0.2 1.9 1 0 0 1 1 1 0 Capsule biosynthesis CapC DUF3431 PF11913.8 CRG92031.1 - 4e-64 216.3 0.0 4.8e-64 216.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) DUF3807 PF12720.7 CRG92032.1 - 1.7e-30 106.7 13.6 8.7e-30 104.3 11.9 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3807) Fungal_trans PF04082.18 CRG92034.1 - 2.7e-06 26.6 0.1 5e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92034.1 - 2.9e-06 27.3 9.1 6.7e-06 26.1 9.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DJ-1_PfpI PF01965.24 CRG92035.1 - 8.2e-17 61.5 0.0 1.1e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family Abhydrolase_1 PF00561.20 CRG92036.1 - 1.1e-07 31.8 0.1 3e-07 30.4 0.1 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG92036.1 - 5.1e-06 25.9 0.0 0.023 13.9 0.0 2.4 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG92036.1 - 1e-05 26.3 0.1 1.4e-05 25.8 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 CRG92036.1 - 8.3e-05 22.2 0.0 0.11 11.9 0.1 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family DLH PF01738.18 CRG92036.1 - 0.04 13.5 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family VirJ PF06057.11 CRG92036.1 - 0.086 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Thioesterase PF00975.20 CRG92036.1 - 0.095 12.8 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.13 CRG92036.1 - 0.13 12.1 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold ERO1 PF04137.15 CRG92037.1 - 7.5e-135 449.7 0.1 9.8e-135 449.3 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) Peroxin-13_N PF04088.13 CRG92038.1 - 1.6e-52 177.6 0.0 2.6e-52 177.0 0.0 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 CRG92038.1 - 8.8e-11 41.3 0.0 1.7e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 CRG92038.1 - 1.3e-07 31.1 0.0 2.2e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain hSH3 PF14603.6 CRG92038.1 - 0.22 12.0 0.0 0.37 11.3 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain ADH_N PF08240.12 CRG92039.1 - 2.6e-28 98.1 0.4 4.5e-28 97.3 0.4 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 CRG92039.1 - 2.9e-22 79.0 0.1 5.4e-22 78.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG92039.1 - 2.2e-05 25.5 0.0 3.4e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG92039.1 - 0.013 14.8 0.1 0.021 14.2 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain adh_short PF00106.25 CRG92039.1 - 0.021 14.3 0.2 0.053 13.0 0.2 1.7 1 0 0 1 1 1 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 CRG92039.1 - 0.079 12.3 0.3 0.12 11.7 0.3 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SSF PF00474.17 CRG92040.1 - 3.5e-20 72.3 30.9 3.5e-20 72.3 30.9 1.8 2 0 0 2 2 2 1 Sodium:solute symporter family LapA_dom PF06305.11 CRG92040.1 - 0.24 11.2 0.1 0.24 11.2 0.1 4.8 7 1 0 7 7 7 0 Lipopolysaccharide assembly protein A domain Isochorismatase PF00857.20 CRG92041.1 - 9.4e-24 84.5 0.0 2.7e-22 79.8 0.0 2.2 1 1 0 1 1 1 1 Isochorismatase family ABM PF03992.16 CRG92042.1 - 2.2e-13 50.1 0.0 2.6e-13 49.9 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase FMO-like PF00743.19 CRG92043.1 - 3.6e-11 42.2 0.0 1.6e-09 36.7 0.0 2.6 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG92043.1 - 1.1e-10 41.3 0.0 1.5e-09 37.5 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG92043.1 - 1.9e-10 40.8 0.0 1.3e-07 31.8 0.0 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 CRG92043.1 - 1.1e-08 34.6 0.0 1.6e-05 24.2 0.0 2.6 3 0 0 3 3 3 2 Thi4 family Pyr_redox_2 PF07992.14 CRG92043.1 - 2e-08 33.8 0.1 1.8e-05 24.1 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG92043.1 - 3.9e-07 29.5 0.1 0.00022 20.5 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG92043.1 - 3.2e-06 27.0 0.2 0.00033 20.4 0.0 3.4 3 1 1 4 4 4 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 CRG92043.1 - 6.6e-05 23.4 0.0 0.1 13.2 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG92043.1 - 0.00031 20.8 0.4 1.7 8.6 0.0 3.1 2 1 0 2 2 2 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 CRG92043.1 - 0.00062 18.9 0.0 2.1 7.3 0.0 3.2 3 0 0 3 3 3 1 Lycopene cyclase protein NAD_binding_7 PF13241.6 CRG92043.1 - 0.00063 20.1 0.0 0.0047 17.4 0.0 2.4 3 0 0 3 3 3 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 CRG92043.1 - 0.00095 19.2 0.0 0.039 14.0 0.0 2.9 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase GIDA PF01134.22 CRG92043.1 - 0.014 14.5 0.7 4.4 6.3 0.0 2.8 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 CRG92043.1 - 0.024 13.7 0.0 0.52 9.3 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain FAD_oxidored PF12831.7 CRG92043.1 - 0.031 13.6 0.1 2.7 7.3 0.0 2.4 3 0 0 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG92043.1 - 0.35 9.5 1.0 2.6 6.6 0.0 2.5 3 0 0 3 3 3 0 HI0933-like protein ECH_1 PF00378.20 CRG92044.1 - 2.4e-34 118.8 0.0 1.2e-17 64.1 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 CRG92044.1 - 2.5e-18 66.7 0.1 2.8e-11 43.5 0.0 2.5 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase 4HBT_3 PF13622.6 CRG92047.1 - 1.4e-42 146.7 1.1 1.7e-42 146.4 1.1 1.0 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 CRG92047.1 - 1.9e-06 27.8 0.3 0.00044 20.1 0.1 2.4 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.22 CRG92047.1 - 0.046 14.1 0.1 8.7 6.8 0.0 2.6 2 1 0 2 2 2 0 Thioesterase superfamily MFS_1 PF07690.16 CRG92048.1 - 3e-24 85.6 37.0 5.3e-23 81.5 30.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG92048.1 - 0.015 13.7 7.5 0.024 13.0 7.5 1.3 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Ilm1 PF10311.9 CRG92048.1 - 1.1 8.9 7.3 2.1 8.0 7.3 1.4 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 Acetyltransf_3 PF13302.7 CRG92049.1 - 5.9e-17 62.6 0.0 7.2e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG92049.1 - 2.9e-08 33.9 0.0 3.8e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 CRG92049.1 - 0.00098 19.5 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GFA PF04828.14 CRG92050.1 - 3.2e-10 40.2 0.1 3.2e-10 40.2 0.1 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme 2_5_RNA_ligase2 PF13563.6 CRG92051.1 - 4.4e-34 117.6 0.1 9.1e-34 116.6 0.1 1.6 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily PAP_central PF04928.17 CRG92051.1 - 7e-29 100.5 0.0 1.2e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain MJ1316 PF04457.12 CRG92051.1 - 9.6e-20 71.1 0.7 2.5e-19 69.8 0.7 1.8 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 CRG92051.1 - 4.1e-06 26.5 0.0 1.3e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Nrap_D2 PF17403.2 CRG92051.1 - 0.00012 21.8 0.0 0.00027 20.8 0.0 1.6 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain NTP_transf_2 PF01909.23 CRG92051.1 - 0.00033 20.9 0.0 0.00091 19.5 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain LigT_PEase PF02834.16 CRG92051.1 - 0.033 14.4 0.0 0.88 9.8 0.0 2.7 2 0 0 2 2 2 0 LigT like Phosphoesterase Exo_endo_phos_2 PF14529.6 CRG92051.1 - 0.12 12.2 1.6 2.5 7.9 0.0 3.5 4 0 0 4 4 4 0 Endonuclease-reverse transcriptase MFS_1 PF07690.16 CRG92052.1 - 3.5e-17 62.4 72.2 4e-14 52.3 41.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92052.1 - 0.054 12.3 24.8 0.15 10.9 5.1 3.0 2 2 1 3 3 3 0 Sugar (and other) transporter APG6 PF04111.12 CRG92053.1 - 9.9e-74 247.2 0.0 1.4e-73 246.7 0.0 1.2 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 CRG92053.1 - 1.5e-41 142.1 14.8 2.5e-41 141.3 14.8 1.4 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF3450 PF11932.8 CRG92053.1 - 0.76 9.0 8.4 2.3 7.5 8.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) Uds1 PF15456.6 CRG92053.1 - 0.98 9.6 7.8 0.28 11.3 4.3 1.8 2 0 0 2 2 2 0 Up-regulated During Septation HAUS-augmin3 PF14932.6 CRG92053.1 - 2 7.9 12.3 2.6 7.6 11.2 1.5 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Scm3 PF10384.9 CRG92054.1 - 1.9e-20 72.3 0.1 5.2e-20 70.9 0.1 1.8 1 0 0 1 1 1 1 Centromere protein Scm3 Myb_DNA-binding PF00249.31 CRG92054.1 - 6.6e-08 32.6 0.2 0.091 13.0 0.0 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG92054.1 - 6.5e-05 23.1 0.9 1.4 9.2 0.5 3.4 3 0 0 3 3 3 2 Myb-like DNA-binding domain PALP PF00291.25 CRG92055.1 - 3.9e-60 203.8 0.3 5.8e-60 203.2 0.3 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme p450 PF00067.22 CRG92056.1 - 2.9e-51 174.7 0.0 3.6e-51 174.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_28 PF02636.17 CRG92057.1 - 1.2e-41 143.1 0.0 1.8e-41 142.5 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 CRG92057.1 - 0.039 13.8 0.0 0.066 13.1 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Glyco_hydro_28 PF00295.17 CRG92059.1 - 5.2e-32 111.2 2.0 7.6e-32 110.6 2.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Pectate_lyase_3 PF12708.7 CRG92059.1 - 3.6e-09 36.8 4.4 3.6e-09 36.8 4.4 2.3 1 1 1 2 2 2 1 Pectate lyase superfamily protein PX PF00787.24 CRG92060.1 - 2.6e-16 59.6 0.0 4.2e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 PX domain DUF2156 PF09924.9 CRG92061.1 - 1.6e-28 99.6 0.0 2.4e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) SR-25 PF10500.9 CRG92061.1 - 5.6 6.5 20.2 4.5 6.8 8.4 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Sigma70_ner PF04546.13 CRG92062.1 - 0.0021 18.0 14.7 0.0029 17.5 14.7 1.4 1 0 0 1 1 1 1 Sigma-70, non-essential region Connexin PF00029.19 CRG92062.1 - 0.031 14.0 13.4 0.042 13.6 13.4 1.1 1 0 0 1 1 1 0 Connexin DDHD PF02862.17 CRG92062.1 - 0.051 13.7 5.5 0.059 13.5 5.5 1.1 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.6 CRG92062.1 - 0.079 13.1 12.5 0.1 12.8 12.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Prothymosin PF03247.14 CRG92062.1 - 0.081 13.4 44.0 0.1 13.1 44.0 1.1 1 0 0 1 1 1 0 Prothymosin/parathymosin family SpoIIP PF07454.11 CRG92062.1 - 0.094 12.2 14.2 0.11 11.9 14.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 CRG92062.1 - 0.097 11.6 10.1 0.11 11.5 10.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Coilin_N PF15862.5 CRG92062.1 - 0.11 12.4 8.6 0.12 12.1 8.6 1.2 1 0 0 1 1 1 0 Coilin N-terminus SID-1_RNA_chan PF13965.6 CRG92062.1 - 0.11 10.8 0.9 0.097 11.1 0.9 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Mpp10 PF04006.12 CRG92062.1 - 0.15 10.4 32.2 0.17 10.3 32.2 1.0 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.14 CRG92062.1 - 0.15 10.3 23.7 0.16 10.2 23.7 1.1 1 0 0 1 1 1 0 CDC45-like protein MRNIP PF15749.5 CRG92062.1 - 0.19 12.5 14.6 0.29 11.9 14.6 1.3 1 0 0 1 1 1 0 MRN-interacting protein RNA_pol_Rpc4 PF05132.14 CRG92062.1 - 0.23 11.9 12.1 0.25 11.7 12.1 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 SDA1 PF05285.12 CRG92062.1 - 0.25 10.8 32.7 0.28 10.6 32.7 1.0 1 0 0 1 1 1 0 SDA1 CCSAP PF15748.5 CRG92062.1 - 0.26 11.4 17.8 0.29 11.3 17.8 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Pes-10 PF07149.11 CRG92062.1 - 0.32 10.0 23.9 0.35 9.9 23.9 1.0 1 0 0 1 1 1 0 Pes-10 RR_TM4-6 PF06459.12 CRG92062.1 - 0.32 10.8 22.1 0.36 10.6 22.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DARPP-32 PF05395.12 CRG92062.1 - 0.54 10.5 22.3 0.69 10.1 22.3 1.2 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 SpoIIIAH PF12685.7 CRG92062.1 - 0.8 9.5 17.9 1 9.1 17.9 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein AAA_11 PF13086.6 CRG92062.1 - 1.1 9.0 9.1 1.3 8.8 9.1 1.1 1 0 0 1 1 1 0 AAA domain DUF5523 PF17661.1 CRG92062.1 - 1.2 8.8 29.5 1.4 8.5 29.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) FYDLN_acid PF09538.10 CRG92062.1 - 1.2 9.9 21.9 1.9 9.2 21.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Presenilin PF01080.17 CRG92062.1 - 1.2 7.8 15.0 1.6 7.4 15.0 1.1 1 0 0 1 1 1 0 Presenilin DUF5308 PF17233.2 CRG92062.1 - 1.4 9.1 5.2 1.8 8.8 5.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Nop14 PF04147.12 CRG92062.1 - 1.6 6.8 35.6 1.7 6.7 35.6 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_polI_A34 PF08208.11 CRG92062.1 - 1.9 8.5 23.4 2.3 8.3 23.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SLC12 PF03522.15 CRG92062.1 - 2.1 7.3 8.4 2.1 7.3 8.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ORC_WH_C PF18137.1 CRG92062.1 - 2.1 8.4 15.2 3 7.9 15.2 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Dsh_C PF12316.8 CRG92062.1 - 2.1 8.7 6.8 2.9 8.2 6.8 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Vfa1 PF08432.10 CRG92062.1 - 2.2 8.6 19.6 2.5 8.4 19.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Serinc PF03348.15 CRG92062.1 - 2.2 7.1 6.3 2.5 7.0 6.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) NPR3 PF03666.13 CRG92062.1 - 2.3 6.9 15.3 2.7 6.7 15.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SMN PF06003.12 CRG92062.1 - 3.1 7.0 10.2 4.1 6.6 10.2 1.1 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF2828 PF11443.8 CRG92062.1 - 3.2 5.7 10.8 4 5.4 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4820 PF16091.5 CRG92062.1 - 3.3 7.0 15.9 4.2 6.7 15.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TRAP_alpha PF03896.16 CRG92062.1 - 3.9 6.6 21.5 5.1 6.2 21.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2151 PF10221.9 CRG92062.1 - 4.1 5.9 12.7 4.7 5.7 12.7 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Merozoite_SPAM PF07133.11 CRG92062.1 - 4.5 7.2 51.2 5.2 7.0 51.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Neur_chan_memb PF02932.16 CRG92062.1 - 6.7 6.7 5.1 6.8 6.7 5.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 CRG92062.1 - 7.1 5.9 36.5 8.5 5.7 36.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TFIIF_alpha PF05793.12 CRG92062.1 - 7.9 4.9 35.3 8.7 4.8 35.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Hid1 PF12722.7 CRG92062.1 - 8 4.4 13.0 8.4 4.4 13.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RPN2_C PF18004.1 CRG92062.1 - 8.8 6.2 26.0 13 5.7 26.0 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Dynamin_N PF00350.23 CRG92062.1 - 8.9 6.3 8.1 11 6.0 8.1 1.2 1 0 0 1 1 1 0 Dynamin family Myco_haema PF05692.12 CRG92062.1 - 9.5 5.1 8.9 12 4.8 8.9 1.1 1 0 0 1 1 1 0 Mycoplasma haemagglutinin RAB3GAP2_C PF14656.6 CRG92062.1 - 9.9 4.3 11.4 12 4.0 11.4 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus MFS_1 PF07690.16 CRG92063.1 - 4.2e-32 111.4 22.4 4.2e-32 111.4 22.4 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92063.1 - 2.3e-13 49.8 3.5 2.3e-13 49.8 3.5 2.3 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CRG92063.1 - 8.3e-08 31.1 1.6 1.3e-07 30.4 1.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PTR2 PF00854.21 CRG92063.1 - 0.83 8.4 10.0 0.16 10.7 4.4 2.3 2 1 0 2 2 2 0 POT family Sigma_reg_N PF13800.6 CRG92063.1 - 1.7 8.9 4.0 3.3 8.1 0.0 3.1 3 0 0 3 3 3 0 Sigma factor regulator N-terminal AAA_33 PF13671.6 CRG92064.1 - 1.2e-20 74.1 0.0 1.5e-20 73.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG92064.1 - 7.4e-07 29.8 0.0 1.1e-06 29.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CRG92064.1 - 5.1e-05 23.7 0.0 8.3e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.20 CRG92064.1 - 0.00014 21.8 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 2 Adenylylsulphate kinase NB-ARC PF00931.22 CRG92064.1 - 0.0011 18.2 0.0 0.006 15.8 0.0 1.8 1 1 0 2 2 2 1 NB-ARC domain dNK PF01712.19 CRG92064.1 - 0.0024 17.8 0.1 1.2 9.0 0.0 2.2 2 0 0 2 2 2 2 Deoxynucleoside kinase Torsin PF06309.11 CRG92064.1 - 0.0037 17.4 0.0 0.0053 16.9 0.0 1.2 1 0 0 1 1 1 1 Torsin KTI12 PF08433.10 CRG92064.1 - 0.0044 16.5 0.0 0.007 15.9 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 CRG92064.1 - 0.0045 16.3 0.0 0.0077 15.5 0.0 1.4 2 0 0 2 2 2 1 Zeta toxin AAA_22 PF13401.6 CRG92064.1 - 0.017 15.4 0.0 0.033 14.5 0.0 1.6 1 1 1 2 2 2 0 AAA domain SRPRB PF09439.10 CRG92064.1 - 0.037 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit CPT PF07931.12 CRG92064.1 - 0.045 13.6 0.0 0.09 12.6 0.0 1.5 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PRK PF00485.18 CRG92064.1 - 0.14 11.9 0.0 2.8 7.6 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family 4HBT PF03061.22 CRG92066.1 - 3.5e-13 49.7 0.3 4.9e-13 49.2 0.3 1.2 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CRG92066.1 - 0.0029 17.7 0.1 0.0033 17.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) SGL PF08450.12 CRG92067.1 - 3.9e-21 75.8 0.3 1.5e-20 73.9 0.1 1.9 2 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 CRG92067.1 - 0.0016 18.6 1.1 0.011 16.0 0.0 2.8 3 1 1 4 4 4 1 Arylesterase Str_synth PF03088.16 CRG92067.1 - 0.0033 17.5 0.0 0.0068 16.5 0.0 1.5 1 0 0 1 1 1 1 Strictosidine synthase He_PIG PF05345.12 CRG92067.1 - 1.9 8.7 6.6 1.9 8.7 1.4 3.0 2 1 1 3 3 3 0 Putative Ig domain NAD_binding_1 PF00175.21 CRG92068.1 - 1.6e-28 99.5 0.0 4.2e-28 98.2 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 CRG92068.1 - 2.7e-16 59.7 0.0 4.8e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 CRG92068.1 - 6.4e-08 32.9 0.0 0.00023 21.3 0.0 2.8 2 1 1 3 3 3 2 Ferric reductase NAD binding domain MFS_1 PF07690.16 CRG92069.1 - 1.9e-34 119.2 27.3 2.6e-34 118.7 27.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92069.1 - 0.00022 20.3 12.5 0.00072 18.5 12.5 1.7 1 1 0 1 1 1 1 Sugar (and other) transporter IQ PF00612.27 CRG92069.1 - 0.00047 19.7 0.9 0.00047 19.7 0.9 2.3 2 0 0 2 2 2 1 IQ calmodulin-binding motif DUF3659 PF12396.8 CRG92070.1 - 1.5e-233 755.1 146.8 6.3e-23 80.5 2.1 12.4 12 0 0 12 12 12 12 Protein of unknown function (DUF3659) RPW8 PF05659.11 CRG92070.1 - 0.028 14.1 2.3 0.13 11.9 0.5 2.3 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 2C_adapt PF08793.10 CRG92070.1 - 0.64 10.2 2.7 9.8 6.4 0.0 4.0 5 0 0 5 5 5 0 2-cysteine adaptor domain Clavanin PF05452.11 CRG92070.1 - 0.73 10.1 4.9 0.52 10.5 0.1 3.5 4 0 0 4 4 4 0 Clavanin p450 PF00067.22 CRG92071.1 - 2.9e-38 131.8 0.0 3.9e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 CRG92072.1 - 2.6e-45 155.0 0.0 3.3e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_3 PF01494.19 CRG92074.1 - 2.8e-25 89.3 0.0 2.3e-24 86.3 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 CRG92074.1 - 3.9e-05 23.8 0.1 8.1e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 CRG92074.1 - 5e-05 22.5 0.0 0.00056 19.0 0.0 2.0 2 0 0 2 2 2 1 Squalene epoxidase DAO PF01266.24 CRG92074.1 - 0.0008 19.1 0.2 0.015 14.9 0.0 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG92074.1 - 0.0033 16.5 0.1 0.37 9.8 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG92074.1 - 0.0034 16.7 0.0 0.006 15.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG92074.1 - 0.02 14.1 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CRG92074.1 - 0.026 13.8 0.0 0.045 13.0 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 CRG92074.1 - 0.059 13.6 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain K_oxygenase PF13434.6 CRG92074.1 - 0.14 11.2 0.0 2.5 7.1 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) MOSC PF03473.17 CRG92075.1 - 2.2e-12 47.1 0.0 4.5e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 MOSC domain Fer2 PF00111.27 CRG92075.1 - 7.6e-08 32.2 0.6 1.8e-07 31.0 0.6 1.7 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NAD_binding_1 PF00175.21 CRG92075.1 - 0.0012 19.5 0.0 0.0037 17.9 0.0 1.9 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_4 PF01565.23 CRG92076.1 - 8.5e-18 64.4 0.1 2.2e-17 63.1 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG92076.1 - 0.0087 16.1 0.1 0.021 14.9 0.1 1.7 1 0 0 1 1 1 1 Berberine and berberine like AMP-binding PF00501.28 CRG92077.1 - 3.1e-68 230.3 0.0 4.8e-68 229.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CRG92077.1 - 5.4e-62 210.0 0.0 6.8e-34 117.3 0.0 3.2 2 2 0 2 2 2 2 Condensation domain PP-binding PF00550.25 CRG92077.1 - 4.4e-20 71.8 0.6 2.5e-10 40.5 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG92077.1 - 6.5e-05 23.8 0.0 0.0002 22.3 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Meckelin PF09773.9 CRG92078.1 - 7.1 4.6 6.4 11 4.0 6.4 1.2 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) FAD_binding_3 PF01494.19 CRG92079.1 - 2.6e-20 73.0 0.0 1.1e-19 70.9 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 CRG92079.1 - 0.03 13.4 0.0 0.14 11.2 0.0 1.9 2 0 0 2 2 2 0 Squalene epoxidase zf-C2H2_4 PF13894.6 CRG92080.1 - 0.015 16.1 1.5 0.015 16.1 1.5 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger Glyco_hydro_64 PF16483.5 CRG92081.1 - 1.1e-124 416.4 1.0 1.3e-124 416.2 1.0 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase CbiD PF01888.17 CRG92081.1 - 0.021 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 CbiD Asp PF00026.23 CRG92082.1 - 7.8e-72 242.3 13.6 9.8e-72 242.0 13.6 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 CRG92082.1 - 1.4e-07 31.9 4.4 0.00024 21.4 3.6 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 CRG92082.1 - 1.4e-06 28.9 3.4 0.015 15.9 1.3 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 CRG92082.1 - 0.00031 20.5 0.1 0.0023 17.7 0.0 2.3 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal DUF3652 PF12372.8 CRG92084.1 - 0.1 12.5 1.0 1 9.3 0.0 2.7 3 0 0 3 3 3 0 Huntingtin protein region FAA_hydrolase PF01557.18 CRG92085.1 - 3.5e-55 187.0 0.0 4.5e-55 186.7 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 CRG92085.1 - 3.9e-23 81.7 0.0 6.9e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal MRJP PF03022.16 CRG92086.1 - 1.4e-09 37.7 0.0 1.9e-09 37.3 0.0 1.1 1 0 0 1 1 1 1 Major royal jelly protein cobW PF02492.19 CRG92087.1 - 3.1e-49 167.0 5.4 5.6e-37 127.0 1.1 2.2 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 CRG92087.1 - 1.8e-20 72.7 0.1 3.5e-16 58.9 0.0 2.6 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain MobB PF03205.14 CRG92087.1 - 0.0025 17.7 0.1 0.0051 16.7 0.1 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B MeaB PF03308.16 CRG92087.1 - 0.0037 16.3 1.0 0.55 9.2 0.1 2.4 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB TrwB_AAD_bind PF10412.9 CRG92087.1 - 0.0039 16.2 0.0 0.52 9.2 0.0 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain GTP_EFTU PF00009.27 CRG92087.1 - 0.005 16.4 3.3 0.21 11.1 0.2 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain GerD PF17898.1 CRG92087.1 - 0.0051 16.8 0.1 0.021 14.8 0.1 2.0 2 0 0 2 2 2 1 Spore germination GerD central core domain TsaE PF02367.17 CRG92087.1 - 0.012 15.6 0.1 0.035 14.1 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 CRG92087.1 - 0.014 14.5 1.8 0.025 13.6 0.2 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 CRG92087.1 - 0.019 15.4 1.1 0.035 14.5 0.2 2.1 2 1 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 CRG92087.1 - 0.024 15.2 0.5 0.088 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 CRG92087.1 - 0.051 13.7 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CRG92087.1 - 0.082 12.2 0.1 0.19 11.0 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 CRG92087.1 - 0.092 13.0 0.3 0.32 11.3 0.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG92087.1 - 0.093 12.7 0.1 11 6.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Viral_helicase1 PF01443.18 CRG92087.1 - 0.093 12.4 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RsgA_GTPase PF03193.16 CRG92087.1 - 0.11 12.4 0.5 8 6.3 0.1 2.5 2 0 0 2 2 2 0 RsgA GTPase AAA PF00004.29 CRG92087.1 - 0.14 12.6 0.6 0.93 9.9 0.0 2.6 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 CRG92087.1 - 0.15 11.9 0.1 0.36 10.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain NOA36 PF06524.12 CRG92087.1 - 0.81 8.9 8.0 1.5 8.1 8.0 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CRG92087.1 - 2.2 6.3 10.7 4.2 5.4 10.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 CRG92087.1 - 5.1 6.8 6.9 12 5.6 6.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sporozoite_P67 PF05642.11 CRG92087.1 - 6.8 4.6 7.0 11 3.9 6.5 1.5 2 0 0 2 2 2 0 Sporozoite P67 surface antigen MFS_1 PF07690.16 CRG92088.1 - 2.6e-32 112.2 41.2 5.8e-31 107.7 28.5 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1180 PF06679.12 CRG92088.1 - 0.24 11.8 0.0 0.37 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Peptidase_S9 PF00326.21 CRG92090.1 - 1.4e-47 162.0 0.1 3e-47 160.9 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 CRG92090.1 - 0.015 14.0 0.0 0.4 9.3 0.0 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Sec63 PF02889.16 CRG92091.1 - 1.1e-164 545.8 0.0 1.4e-92 309.5 0.0 2.2 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 CRG92091.1 - 4.2e-49 166.7 0.1 1.4e-27 96.6 0.0 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 CRG92091.1 - 2e-31 108.4 0.6 7.3e-31 106.6 0.6 2.0 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 CRG92091.1 - 1.4e-23 83.8 0.0 1e-12 48.4 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 CRG92091.1 - 2.5e-12 47.1 0.0 1.6e-07 31.6 0.0 3.7 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 CRG92091.1 - 4.7e-06 26.9 0.6 0.028 14.7 0.1 4.0 3 2 0 3 3 3 2 AAA domain PhoH PF02562.16 CRG92091.1 - 0.0071 15.8 0.1 0.76 9.2 0.0 3.0 3 0 0 3 3 3 1 PhoH-like protein UvrD-helicase PF00580.21 CRG92091.1 - 0.059 12.9 0.1 1.1 8.7 0.0 2.7 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain T2SSE PF00437.20 CRG92091.1 - 0.096 11.7 0.0 1.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein MutS_V PF00488.21 CRG92092.1 - 1.3e-73 247.1 0.0 2.4e-73 246.2 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 CRG92092.1 - 2.4e-42 145.3 2.4 4.5e-42 144.5 2.4 1.5 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 CRG92092.1 - 8.6e-22 77.5 0.0 2.5e-21 76.0 0.0 1.9 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 CRG92092.1 - 5.9e-06 26.6 0.0 1.6e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 MutS domain II Cob_adeno_trans PF01923.18 CRG92092.1 - 0.019 15.1 0.1 0.3 11.2 0.1 2.6 2 0 0 2 2 2 0 Cobalamin adenosyltransferase AAA_29 PF13555.6 CRG92092.1 - 0.048 13.4 0.0 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 CRG92092.1 - 0.072 13.6 0.0 0.42 11.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 CRG92092.1 - 0.1 13.0 0.6 12 6.2 0.2 3.2 3 1 0 3 3 3 0 AAA ATPase domain AAA_27 PF13514.6 CRG92092.1 - 0.12 12.0 0.0 0.31 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 CRG92092.1 - 0.12 12.4 0.0 0.75 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain Ureidogly_lyase PF04115.12 CRG92093.1 - 2e-60 203.8 0.1 5.4e-29 101.3 0.0 2.0 2 0 0 2 2 2 2 Ureidoglycolate lyase Tim17 PF02466.19 CRG92094.1 - 9.9e-12 45.2 0.2 1.4e-11 44.7 0.2 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Brix PF04427.18 CRG92095.1 - 1.5e-30 106.8 0.0 2.3e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Brix domain NUP50 PF08911.11 CRG92095.1 - 0.1 13.3 0.6 0.43 11.3 0.6 2.1 1 1 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) RNase_P_p30 PF01876.16 CRG92096.1 - 3.1e-65 219.6 0.0 4.3e-65 219.2 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Pkinase PF00069.25 CRG92097.1 - 2.6e-66 223.7 0.3 3e-66 223.5 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92097.1 - 1.9e-19 70.0 0.0 2.7e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 CRG92097.1 - 1.1e-07 32.0 0.0 8.2e-05 22.6 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 CRG92097.1 - 0.0032 16.3 0.0 0.0053 15.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 CRG92097.1 - 0.0083 15.5 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 CRG92097.1 - 0.015 14.6 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 CRG92097.1 - 0.031 13.9 1.4 0.048 13.2 0.1 2.0 3 0 0 3 3 3 0 Choline/ethanolamine kinase tRNA-synt_1 PF00133.22 CRG92098.1 - 7.6e-218 724.6 1.9 9.8e-217 721.0 1.9 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 CRG92098.1 - 7.9e-33 113.6 0.7 7.9e-33 113.6 0.7 2.1 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 CRG92098.1 - 4e-15 55.5 3.0 1.9e-06 26.9 0.1 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 CRG92098.1 - 1.1e-08 34.8 4.7 3.5e-06 26.6 0.0 3.1 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 CRG92098.1 - 0.0069 15.8 0.0 0.92 8.8 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain ADH_zinc_N_2 PF13602.6 CRG92100.1 - 2e-19 70.9 0.0 5e-19 69.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG92100.1 - 6.6e-16 58.5 0.2 1.3e-15 57.5 0.1 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG92100.1 - 0.00099 19.0 0.0 0.0017 18.3 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain CusF_Ec PF11604.8 CRG92100.1 - 0.0055 16.6 0.1 0.56 10.2 0.0 2.6 2 0 0 2 2 2 1 Copper binding periplasmic protein CusF Amidase PF01425.21 CRG92101.1 - 2.9e-85 286.9 0.1 3.7e-85 286.6 0.1 1.1 1 0 0 1 1 1 1 Amidase Isochorismatase PF00857.20 CRG92101.1 - 9.6e-37 126.8 0.0 2.1e-36 125.7 0.0 1.5 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans PF04082.18 CRG92102.1 - 6.6e-26 90.9 0.6 1.2e-25 90.1 0.6 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92102.1 - 5.6e-05 23.2 7.1 0.0001 22.3 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DIOX_N PF14226.6 CRG92103.1 - 3.2e-24 85.9 0.6 8.1e-24 84.7 0.6 1.7 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 CRG92103.1 - 1e-21 77.3 0.0 2.2e-21 76.3 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Transp_cyt_pur PF02133.15 CRG92104.1 - 5.8e-97 325.2 36.5 7.2e-97 324.9 36.5 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Gly_transf_sug PF04488.15 CRG92105.1 - 3.6e-09 37.1 0.0 6.8e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 CRG92105.1 - 0.078 12.3 0.0 0.29 10.4 0.0 1.8 2 0 0 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Aldo_ket_red PF00248.21 CRG92106.1 - 1.2e-40 139.5 0.0 1.5e-40 139.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LIP1 PF15904.5 CRG92107.1 - 0.11 12.8 0.0 0.35 11.2 0.0 1.8 1 0 0 1 1 1 0 LKB1 serine/threonine kinase interacting protein 1 AA_permease PF00324.21 CRG92109.1 - 1.2e-114 383.6 41.6 1.8e-114 383.0 41.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG92109.1 - 2.4e-31 109.0 47.8 3e-31 108.7 47.8 1.1 1 0 0 1 1 1 1 Amino acid permease Sugar_tr PF00083.24 CRG92110.1 - 4.9e-83 279.5 24.6 5.9e-83 279.2 24.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92110.1 - 2.6e-14 52.9 36.9 1.9e-10 40.2 27.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 CRG92110.1 - 0.0011 17.9 3.0 0.0011 17.9 3.0 2.2 2 0 0 2 2 2 1 MFS_1 like family MFS_1 PF07690.16 CRG92111.1 - 6.8e-18 64.7 33.8 4.5e-09 35.7 11.0 3.2 3 0 0 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 CRG92111.1 - 6.1e-06 25.1 10.8 7.1e-05 21.5 2.1 3.2 3 0 0 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 CRG92111.1 - 0.03 13.2 0.5 7.1 5.4 0.0 2.5 2 1 0 2 2 2 0 MFS_1 like family zf-rbx1 PF12678.7 CRG92114.1 - 1.8e-09 37.7 3.6 3.3e-09 36.9 3.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 CRG92114.1 - 1.3e-07 31.8 7.7 4.1e-07 30.2 7.7 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 CRG92114.1 - 1.1e-06 28.4 2.2 2e-06 27.6 2.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 CRG92114.1 - 2.2e-05 24.4 1.9 4.3e-05 23.5 1.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 CRG92114.1 - 3.8e-05 23.4 3.0 8.1e-05 22.4 3.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 CRG92114.1 - 0.00012 21.7 0.9 0.00023 20.7 0.9 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_3 PF13920.6 CRG92114.1 - 0.00017 21.3 6.3 0.00023 20.9 2.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG92114.1 - 0.00021 21.2 3.2 0.0012 18.8 3.7 1.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 CRG92114.1 - 0.0013 18.8 3.1 0.0031 17.5 3.1 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 CRG92114.1 - 0.0099 15.7 3.8 0.021 14.7 3.8 1.5 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 CRG92114.1 - 0.05 13.4 1.7 0.41 10.4 0.2 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_4 PF15227.6 CRG92114.1 - 0.088 13.0 0.9 0.17 12.0 0.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 CRG92114.1 - 0.23 11.8 1.7 0.42 10.9 1.7 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 CRG92114.1 - 7.5 6.4 5.5 1.5 8.7 1.9 1.6 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF3431 PF11913.8 CRG92115.1 - 3.9e-90 301.3 1.0 4.9e-90 301.0 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Sugar_tr PF00083.24 CRG92116.1 - 7.4e-80 269.0 24.0 9e-80 268.7 24.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92116.1 - 3e-12 46.1 65.2 8.9e-11 41.3 34.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily p450 PF00067.22 CRG92117.1 - 6.9e-45 153.6 0.0 1.3e-44 152.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 PNP_UDP_1 PF01048.20 CRG92117.1 - 1.6e-06 27.6 0.0 3.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily PHD PF00628.29 CRG92117.1 - 0.8 9.6 17.0 0.02 14.8 10.0 2.1 2 0 0 2 2 2 0 PHD-finger DUF3328 PF11807.8 CRG92118.1 - 1.5e-25 90.3 7.9 2.3e-24 86.4 7.9 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3328) DUF4246 PF14033.6 CRG92119.1 - 8.1e-05 21.9 0.1 0.00011 21.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) DUF4834 PF16118.5 CRG92119.1 - 0.026 15.5 0.2 0.17 12.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RTC_insert PF05189.13 CRG92120.1 - 5.2e-30 104.0 0.0 1.1e-29 103.0 0.0 1.6 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain RTC PF01137.21 CRG92120.1 - 2.9e-26 92.1 0.0 3.7e-26 91.7 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase 3-HAO PF06052.12 CRG92121.1 - 1.5e-43 148.0 0.0 1.8e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 CRG92121.1 - 0.0028 17.3 0.0 0.0053 16.5 0.0 1.5 1 1 0 1 1 1 1 Cupin domain DZR PF12773.7 CRG92121.1 - 0.0055 16.7 0.5 0.011 15.7 0.5 1.5 1 0 0 1 1 1 1 Double zinc ribbon AraC_binding PF02311.19 CRG92121.1 - 0.0094 15.9 0.1 0.015 15.2 0.1 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 CRG92121.1 - 0.036 13.7 0.1 0.051 13.2 0.1 1.2 1 0 0 1 1 1 0 Cupin FYVE PF01363.21 CRG92121.1 - 0.07 13.3 0.9 0.11 12.6 0.9 1.4 1 0 0 1 1 1 0 FYVE zinc finger Auxin_BP PF02041.16 CRG92121.1 - 0.11 12.1 0.1 0.15 11.7 0.1 1.1 1 0 0 1 1 1 0 Auxin binding protein PknG_rubred PF16919.5 CRG92121.1 - 0.16 12.1 1.1 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein kinase G rubredoxin domain zf-RRN7 PF11781.8 CRG92121.1 - 0.3 10.8 4.2 2.2 8.0 0.3 3.1 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ADK_lid PF05191.14 CRG92121.1 - 0.85 9.7 3.0 9.9 6.2 0.2 2.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid Nudix_N_2 PF14803.6 CRG92121.1 - 1.3 9.1 5.2 3.5 7.6 0.2 2.8 1 1 3 4 4 4 0 Nudix N-terminal CAP_GLY PF01302.25 CRG92122.1 - 1.8e-14 53.5 0.2 3.3e-14 52.6 0.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 CRG92122.1 - 5.2e-09 35.8 10.7 4.8e-05 23.1 0.9 2.5 2 0 0 2 2 2 2 CLIP1 zinc knuckle AAA_13 PF13166.6 CRG92122.1 - 0.0024 16.6 11.8 0.0024 16.6 11.8 2.8 2 1 1 3 3 3 1 AAA domain Dynamitin PF04912.14 CRG92122.1 - 0.0026 17.1 17.5 0.0026 17.1 17.5 2.2 1 1 1 2 2 2 1 Dynamitin NPV_P10 PF05531.12 CRG92122.1 - 0.028 14.9 2.8 0.028 14.9 2.8 3.5 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 CRG92122.1 - 0.046 13.8 17.1 0.12 12.4 3.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF573 PF04504.14 CRG92122.1 - 0.22 12.2 4.2 0.36 11.5 0.2 2.7 2 1 0 2 2 2 0 Protein of unknown function, DUF573 Fez1 PF06818.15 CRG92122.1 - 0.55 10.7 36.6 7 7.0 3.0 3.3 1 1 1 2 2 2 0 Fez1 Spectrin PF00435.21 CRG92122.1 - 0.72 10.4 28.6 3.3 8.2 2.7 3.4 1 1 1 3 3 3 0 Spectrin repeat C1_2 PF03107.16 CRG92122.1 - 0.85 10.0 3.5 13 6.2 0.2 2.3 2 0 0 2 2 2 0 C1 domain HAUS-augmin3 PF14932.6 CRG92122.1 - 1.3 8.6 30.3 0.064 12.8 7.9 3.1 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 AAA_assoc_2 PF16193.5 CRG92122.1 - 1.8 8.9 4.0 1.5 9.2 0.4 2.4 2 0 0 2 2 2 0 AAA C-terminal domain TPR_MLP1_2 PF07926.12 CRG92122.1 - 3 7.9 37.8 0.25 11.4 15.6 3.4 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DASH_Dam1 PF08653.10 CRG92122.1 - 5.7 6.8 6.8 34 4.3 1.0 3.6 3 1 0 3 3 3 0 DASH complex subunit Dam1 STAT_alpha PF01017.20 CRG92122.1 - 5.9 6.8 19.5 8.8 6.2 0.1 2.5 2 1 0 2 2 2 0 STAT protein, all-alpha domain Spc7 PF08317.11 CRG92122.1 - 8.6 5.1 37.0 0.88 8.4 9.1 3.1 2 1 1 3 3 3 0 Spc7 kinetochore protein ATG16 PF08614.11 CRG92122.1 - 9.3 6.4 51.5 2.2 8.5 16.4 3.9 3 1 1 4 4 3 0 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 CRG92122.1 - 9.3 6.6 24.0 4.8 7.6 3.0 4.6 4 1 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Pkinase PF00069.25 CRG92123.1 - 5.5e-37 127.6 0.0 2.6e-20 72.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92123.1 - 4.7e-14 52.3 0.0 1.7e-06 27.6 0.0 2.9 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 CRG92123.1 - 0.00053 19.4 0.0 0.48 9.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 CRG92123.1 - 0.035 14.0 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SpoIIE PF07228.12 CRG92124.1 - 9.4e-13 48.5 0.1 5.2e-12 46.1 0.2 1.9 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 CRG92124.1 - 8.5e-09 35.4 0.5 8.5e-09 35.4 0.5 1.9 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C PF00481.21 CRG92124.1 - 8.5e-08 32.1 0.1 0.0054 16.4 0.0 2.4 2 0 0 2 2 2 2 Protein phosphatase 2C WD40 PF00400.32 CRG92126.1 - 6.7e-34 115.4 24.5 1.6e-08 35.1 0.0 8.0 7 1 0 7 7 7 5 WD domain, G-beta repeat PRP4 PF08799.11 CRG92126.1 - 1.3e-14 53.4 5.5 2.4e-14 52.5 5.5 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like ANAPC4_WD40 PF12894.7 CRG92126.1 - 1.4e-12 47.7 1.3 0.0062 16.8 0.1 5.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 CRG92126.1 - 0.00065 19.6 0.0 0.3 11.0 0.0 3.2 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 CRG92126.1 - 0.0093 15.3 0.0 0.056 12.8 0.0 2.3 3 0 0 3 3 3 1 WD40-like domain DUF5639 PF18690.1 CRG92126.1 - 0.048 13.8 0.2 0.51 10.5 0.0 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5639) Lactonase PF10282.9 CRG92126.1 - 0.18 11.0 0.1 1.4 8.1 0.0 2.5 4 1 0 4 4 4 0 Lactonase, 7-bladed beta-propeller HSCB_C PF07743.13 CRG92127.1 - 1.2e-15 57.7 0.3 3.9e-15 56.1 0.1 1.8 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 CRG92127.1 - 1.5e-06 28.2 0.1 3.8e-06 26.9 0.1 1.6 1 0 0 1 1 1 1 DnaJ domain BTB PF00651.31 CRG92128.1 - 0.009 16.2 0.5 0.25 11.6 0.0 2.7 3 0 0 3 3 3 1 BTB/POZ domain ketoacyl-synt PF00109.26 CRG92129.1 - 1.7e-72 244.0 0.0 4.5e-72 242.7 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 CRG92129.1 - 3.9e-47 161.0 0.0 3.9e-47 161.0 0.0 2.4 3 0 0 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 CRG92129.1 - 1e-43 150.1 0.0 2.4e-43 148.8 0.0 1.7 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG92129.1 - 1.2e-34 118.9 0.7 1.2e-34 118.9 0.7 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG92129.1 - 2.8e-11 43.8 0.0 6.9e-10 39.4 0.0 2.6 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 CRG92129.1 - 3.8e-10 40.0 0.2 1e-09 38.6 0.2 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site PS-DH PF14765.6 CRG92129.1 - 5.5e-10 39.0 0.0 1.1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 CRG92129.1 - 0.00023 20.6 0.1 0.0007 19.0 0.1 1.8 1 0 0 1 1 1 1 Thiolase, N-terminal domain Lactamase_B PF00753.27 CRG92130.1 - 4.9e-15 56.1 4.3 5.5e-13 49.4 4.0 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 CRG92130.1 - 0.0003 20.4 0.4 0.00075 19.1 0.3 1.8 1 1 1 2 2 2 1 Beta-lactamase superfamily domain BLACT_WH PF17778.1 CRG92130.1 - 0.0029 17.6 0.1 0.02 14.8 0.0 2.4 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain EthD PF07110.11 CRG92131.1 - 4.4e-18 66.2 0.3 5.9e-18 65.8 0.3 1.2 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 CRG92131.1 - 0.00014 22.3 0.1 0.00022 21.6 0.1 1.4 1 0 0 1 1 1 1 Methylmuconolactone methyl-isomerase Aldo_ket_red PF00248.21 CRG92132.1 - 2.5e-53 181.2 0.0 3.3e-53 180.8 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family p450 PF00067.22 CRG92132.1 - 1.4e-30 106.5 0.0 2.5e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_108 PF05838.12 CRG92132.1 - 0.055 13.9 0.1 20 5.7 0.0 2.7 2 0 0 2 2 2 0 Glycosyl hydrolase 108 Fungal_trans PF04082.18 CRG92133.1 - 4.3e-13 48.9 0.3 1.3e-12 47.3 0.0 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92133.1 - 9.5e-11 41.6 11.4 1.8e-10 40.8 11.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 CRG92134.1 - 5.6e-46 157.1 43.2 5.2e-44 150.6 45.0 2.3 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG92134.1 - 5.5e-11 41.6 23.9 8.2e-11 41.0 23.9 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ycf1 PF05758.12 CRG92134.1 - 0.26 9.1 3.8 0.4 8.5 3.8 1.2 1 0 0 1 1 1 0 Ycf1 DUF2157 PF09925.9 CRG92134.1 - 0.39 10.5 16.0 0.19 11.5 4.6 4.5 2 1 2 4 4 4 0 Predicted membrane protein (DUF2157) TEX19 PF15553.6 CRG92134.1 - 0.75 9.7 4.0 0.71 9.8 2.4 1.7 2 0 0 2 2 2 0 Testis-expressed protein 19 Zip PF02535.22 CRG92134.1 - 4.1 6.5 9.5 0.19 10.9 2.9 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Neurensin PF14927.6 CRG92134.1 - 8.3 6.1 7.7 2.7 7.7 0.2 3.5 2 1 1 3 3 3 0 Neurensin MCPVI PF02993.14 CRG92135.1 - 0.0032 17.3 0.1 0.0062 16.4 0.1 1.4 1 0 0 1 1 1 1 Minor capsid protein VI LacI PF00356.21 CRG92135.1 - 0.0035 17.1 0.9 0.019 14.7 0.1 2.4 2 0 0 2 2 2 1 Bacterial regulatory proteins, lacI family MarR PF01047.22 CRG92135.1 - 0.025 14.5 0.1 0.15 12.0 0.0 2.4 2 0 0 2 2 2 0 MarR family AflR PF08493.10 CRG92136.1 - 3.7e-17 62.7 2.4 7.4e-17 61.7 1.8 1.6 1 1 0 1 1 1 1 Aflatoxin regulatory protein adh_short PF00106.25 CRG92137.1 - 6.1e-28 97.6 0.9 4.4e-19 68.7 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92137.1 - 3.4e-23 82.4 0.1 3.6e-18 66.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92137.1 - 0.00038 20.4 0.1 0.00078 19.4 0.0 1.4 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 CRG92137.1 - 0.022 14.2 0.0 0.077 12.3 0.0 1.9 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 CRG92137.1 - 0.13 11.6 0.1 0.24 10.7 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DSBA PF01323.20 CRG92138.1 - 8.2e-19 68.1 0.0 9.8e-19 67.9 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain RPN7 PF10602.9 CRG92139.1 - 5.4e-46 156.5 0.0 1e-45 155.6 0.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 CRG92139.1 - 7.9e-11 42.4 0.0 6e-10 39.6 0.0 2.4 2 0 0 2 2 2 1 PCI domain TPR_16 PF13432.6 CRG92139.1 - 0.00099 19.7 2.3 1.8 9.3 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 CRG92139.1 - 0.26 11.5 5.1 0.51 10.6 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat CDK2AP PF09806.9 CRG92140.1 - 4.8 7.2 11.5 13 5.8 3.9 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase 2-associated protein ATP_transf PF09830.9 CRG92141.1 - 2.6e-20 72.3 0.1 4.8e-20 71.5 0.1 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase DUF4931 PF16285.5 CRG92141.1 - 0.0039 16.5 0.0 0.0059 15.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4931) GalP_UDP_transf PF01087.22 CRG92141.1 - 0.026 15.0 0.0 0.05 14.0 0.0 1.4 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, N-terminal domain zf-C2H2 PF00096.26 CRG92142.1 - 5.3e-06 26.6 16.1 0.14 12.7 0.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type YL1 PF05764.13 CRG92142.1 - 0.019 15.1 1.4 0.033 14.3 1.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein zf-C2H2_4 PF13894.6 CRG92142.1 - 0.039 14.8 19.2 1.1 10.2 0.4 4.9 4 1 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.7 CRG92142.1 - 0.097 13.1 1.9 2 8.9 0.6 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 CRG92142.1 - 0.098 12.7 2.6 4.7 7.3 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG92142.1 - 2.9 8.3 6.4 3.3 8.1 0.8 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding LtrA PF06772.11 CRG92143.1 - 1.2e-17 64.2 21.6 1.2e-17 64.2 21.6 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) LSM PF01423.22 CRG92144.1 - 5.8e-21 74.0 0.9 7.8e-21 73.6 0.9 1.1 1 0 0 1 1 1 1 LSM domain Peptidase_M1_N PF17900.1 CRG92145.1 - 1.2e-05 25.6 0.1 0.036 14.3 0.1 2.6 3 0 0 3 3 3 2 Peptidase M1 N-terminal domain Peptidase_M1 PF01433.20 CRG92145.1 - 0.04 13.5 0.0 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M1 domain SPATIAL PF15256.6 CRG92145.1 - 0.09 13.1 0.8 0.19 12.0 0.8 1.5 1 0 0 1 1 1 0 SPATIAL CDP-OH_P_transf PF01066.21 CRG92146.1 - 3.5e-16 59.7 0.2 3.5e-16 59.7 0.2 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ACCA PF03255.14 CRG92146.1 - 0.24 11.3 0.0 0.4 10.6 0.0 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit PWWP PF00855.17 CRG92147.1 - 6.4e-17 61.8 3.4 1.5e-16 60.6 0.0 3.0 2 0 0 2 2 2 1 PWWP domain Gemini_BL1 PF00845.19 CRG92147.1 - 4.4 6.8 6.6 0.26 10.8 1.0 1.7 2 0 0 2 2 2 0 Geminivirus BL1 movement protein PAP2_3 PF14378.6 CRG92148.1 - 6.7e-34 117.2 15.2 4.7e-16 59.0 0.0 3.2 3 0 0 3 3 3 3 PAP2 superfamily PAP2 PF01569.21 CRG92148.1 - 0.00029 20.6 1.5 0.00071 19.4 0.4 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 CRG92148.1 - 0.95 10.0 5.0 0.29 11.7 0.2 2.6 2 0 0 2 2 2 0 PAP2 superfamily C-terminal Tachystatin_B PF11478.8 CRG92149.1 - 0.0011 18.8 0.5 0.0028 17.5 0.5 1.6 1 0 0 1 1 1 1 Antimicrobial chitin binding protein tachystatin B F-box-like PF12937.7 CRG92149.1 - 0.08 12.8 0.6 0.17 11.8 0.1 1.8 2 0 0 2 2 2 0 F-box-like ComA PF02679.15 CRG92150.1 - 5e-90 301.2 0.0 6e-90 301.0 0.0 1.0 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) DUF2542 PF10808.8 CRG92150.1 - 0.04 14.4 0.0 0.069 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2542) p450 PF00067.22 CRG92151.1 - 1e-55 189.4 0.0 1.4e-55 188.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SHD1 PF03983.12 CRG92152.1 - 3.7e-35 119.6 0.0 6.6e-35 118.8 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_1 PF00018.28 CRG92152.1 - 5.3e-32 109.2 5.8 1.4e-11 43.8 0.0 4.3 4 0 0 4 4 4 3 SH3 domain SH3_9 PF14604.6 CRG92152.1 - 3.5e-30 103.6 9.4 2.2e-13 49.8 0.5 3.8 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 CRG92152.1 - 1.2e-17 63.3 0.0 3.9e-07 29.6 0.0 4.1 4 0 0 4 4 4 3 Variant SH3 domain SH3_10 PF17902.1 CRG92152.1 - 0.00046 20.2 0.1 0.12 12.4 0.0 3.3 3 0 0 3 3 3 1 SH3 domain SAM_4 PF18017.1 CRG92152.1 - 0.014 15.4 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SH3_3 PF08239.11 CRG92152.1 - 0.018 15.3 2.5 0.31 11.3 0.3 2.7 2 0 0 2 2 2 0 Bacterial SH3 domain DUF1720 PF08226.11 CRG92152.1 - 0.021 15.2 131.8 0.024 15.0 7.1 6.0 1 1 3 4 4 4 0 Domain of unknown function (DUF1720) SAM_1 PF00536.30 CRG92152.1 - 0.025 15.0 0.0 0.046 14.2 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PRKCSH PF07915.13 CRG92153.1 - 3.1e-21 76.2 1.6 5.3e-21 75.4 0.2 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein ATG27 PF09451.10 CRG92153.1 - 0.0013 18.7 0.1 0.0024 17.8 0.1 1.4 1 0 0 1 1 1 1 Autophagy-related protein 27 PRA-PH PF01503.17 CRG92153.1 - 0.19 12.2 1.9 2.3 8.7 0.1 2.8 3 0 0 3 3 3 0 Phosphoribosyl-ATP pyrophosphohydrolase Gene66 PF02053.15 CRG92154.1 - 0.015 14.9 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 Gene 66 (IR5) protein Pirin PF02678.16 CRG92156.1 - 1e-30 105.9 0.1 2.2e-30 104.8 0.1 1.6 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 CRG92156.1 - 2.3e-23 82.5 0.0 1.2e-22 80.2 0.0 2.0 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 CRG92156.1 - 1.9e-06 27.5 1.6 9.1e-05 22.1 1.1 2.4 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 CRG92156.1 - 0.096 12.4 0.1 0.69 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF861) PMT PF02366.18 CRG92157.1 - 3.2e-86 288.9 15.4 5.5e-86 288.1 15.4 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 CRG92157.1 - 3.6e-69 232.3 0.8 3.6e-69 232.3 0.8 3.3 3 1 1 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 CRG92157.1 - 3.2e-16 59.7 0.0 4.9e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 CRG92157.1 - 0.0084 16.3 3.4 0.0084 16.3 3.4 3.9 4 1 1 5 5 5 2 Dolichyl-phosphate-mannose-protein mannosyltransferase MFS_1 PF07690.16 CRG92159.1 - 8.3e-35 120.3 31.7 8.3e-35 120.3 31.7 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily WD40 PF00400.32 CRG92160.1 - 0.00024 21.9 8.5 5.5 8.0 0.1 5.6 6 1 0 6 6 6 2 WD domain, G-beta repeat Kri1 PF05178.12 CRG92160.1 - 0.12 13.0 3.6 1.3 9.7 0.3 2.5 2 1 0 2 2 2 0 KRI1-like family Dynein_IC2 PF11540.8 CRG92160.1 - 0.24 11.4 2.6 0.6 10.1 2.6 1.6 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 Radial_spoke_3 PF06098.11 CRG92160.1 - 2.1 7.6 7.3 4.4 6.5 1.8 2.3 2 0 0 2 2 2 0 Radial spoke protein 3 ATP-synt_E PF05680.12 CRG92161.1 - 1.8e-18 66.7 0.0 1.9e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 ATP synthase E chain CSN8_PSD8_EIF3K PF10075.9 CRG92162.1 - 2.9e-26 92.2 0.1 4.2e-26 91.6 0.1 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Cas_Csm6 PF09659.10 CRG92162.1 - 0.021 13.6 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) STT3 PF02516.14 CRG92163.1 - 1.4e-147 492.6 34.6 3.2e-143 478.2 31.9 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF3453 PF11935.8 CRG92164.1 - 1.8e-66 224.0 1.7 5.1e-66 222.5 1.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3453) Sds3 PF08598.11 CRG92165.1 - 6.5e-13 49.2 3.0 1.8e-12 47.8 0.0 2.3 2 0 0 2 2 2 1 Sds3-like DUF5582 PF17819.1 CRG92165.1 - 0.34 11.4 3.9 8.8 6.8 0.1 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5582) RRM_1 PF00076.22 CRG92166.1 - 9.5e-10 38.2 0.0 8.2e-06 25.6 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIF_alpha PF05793.12 CRG92166.1 - 0.28 9.7 27.2 0.64 8.6 27.2 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 CRG92166.1 - 4.6 5.9 10.3 12 4.5 10.3 1.8 1 0 0 1 1 1 0 Presenilin AA_permease_2 PF13520.6 CRG92167.1 - 2e-47 162.0 29.0 2e-47 162.0 29.0 2.0 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 CRG92167.1 - 1.4e-15 56.9 43.2 3.8e-13 48.9 43.2 2.1 1 1 0 1 1 1 1 Amino acid permease Baculo_PEP_C PF04513.12 CRG92168.1 - 2.7 8.0 27.0 4.1 7.4 0.4 4.8 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 CRG92168.1 - 4.8 4.6 86.4 0.052 11.1 15.4 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 CRG92168.1 - 6.7 6.0 64.7 1.4 8.2 24.6 4.5 2 1 3 5 5 5 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 CRG92168.1 - 8.6 6.4 41.1 0.48 10.5 5.1 5.5 2 2 1 4 4 4 0 Protein of unknown function (DUF1664) Methyltransf_16 PF10294.9 CRG92170.1 - 0.064 13.0 0.0 12 5.5 0.0 2.3 2 0 0 2 2 2 0 Lysine methyltransferase Cys_Met_Meta_PP PF01053.20 CRG92171.1 - 5.7e-129 430.0 0.0 1.4e-128 428.7 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme RNA_pol_Rbc25 PF08292.12 CRG92171.1 - 6.3e-32 110.5 0.2 1.4e-31 109.4 0.2 1.6 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 CRG92171.1 - 1.7e-13 50.7 0.0 6.6e-13 48.8 0.0 2.1 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 Aminotran_1_2 PF00155.21 CRG92171.1 - 3.9e-08 32.9 0.1 6.2e-08 32.2 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 CRG92171.1 - 8e-05 22.1 0.8 0.00014 21.3 0.8 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CRG92171.1 - 0.00057 19.0 0.2 0.00093 18.2 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class-V S1 PF00575.23 CRG92171.1 - 0.05 14.0 0.0 0.094 13.1 0.0 1.4 1 0 0 1 1 1 0 S1 RNA binding domain NUFIP1 PF10453.9 CRG92172.1 - 2.7e-15 56.0 6.1 2.7e-15 56.0 6.1 2.5 4 0 0 4 4 4 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH PF00642.24 CRG92172.1 - 7.1e-08 32.2 5.8 1.2e-07 31.5 5.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 CRG92172.1 - 2.3e-06 27.5 7.6 3.9e-06 26.7 7.6 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 CRG92172.1 - 3.5e-05 23.5 8.4 5.7e-05 22.8 8.4 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 CRG92172.1 - 0.0055 17.4 0.0 0.0055 17.4 0.0 2.5 2 0 0 2 2 2 1 Torus domain KASH_CCD PF14662.6 CRG92173.1 - 0.0065 16.3 12.7 0.0065 16.3 12.7 5.5 1 1 5 6 6 6 3 Coiled-coil region of CCDC155 or KASH DUF4201 PF13870.6 CRG92173.1 - 0.0065 16.2 67.2 0.04 13.7 14.6 4.3 2 1 2 4 4 4 2 Domain of unknown function (DUF4201) HALZ PF02183.18 CRG92173.1 - 0.0072 16.5 58.3 0.24 11.7 0.4 9.3 4 2 4 8 8 8 5 Homeobox associated leucine zipper BLOC1_2 PF10046.9 CRG92173.1 - 0.0079 16.5 48.0 3.7 7.9 11.4 5.9 3 2 2 5 5 5 4 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 CRG92173.1 - 0.021 15.3 13.0 0.021 15.3 13.0 4.8 2 2 2 4 4 4 0 Apg6 coiled-coil region Filament PF00038.21 CRG92173.1 - 0.11 12.0 66.2 0.0095 15.5 44.3 2.8 1 1 1 2 2 2 0 Intermediate filament protein FUSC PF04632.12 CRG92173.1 - 0.14 10.6 24.5 0.0038 15.8 16.7 2.0 2 1 0 2 2 2 0 Fusaric acid resistance protein family DUF1192 PF06698.11 CRG92173.1 - 0.56 10.3 6.4 0.67 10.1 0.3 4.0 3 1 0 4 4 3 0 Protein of unknown function (DUF1192) ERM PF00769.19 CRG92173.1 - 0.66 9.7 60.7 0.12 12.2 21.4 2.7 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF2353 PF09789.9 CRG92173.1 - 1.6 8.0 61.5 0.66 9.3 13.5 3.4 1 1 1 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) Spc7 PF08317.11 CRG92173.1 - 1.8 7.4 66.2 2.4 7.0 33.5 4.0 1 1 3 4 4 4 0 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 CRG92173.1 - 2 8.5 73.1 1.4 9.0 14.5 5.7 2 2 3 5 5 5 0 TPR/MLP1/MLP2-like protein MAD PF05557.13 CRG92173.1 - 3.4 5.9 71.0 4.9 5.4 1.4 4.4 1 1 1 2 2 2 0 Mitotic checkpoint protein FlaC_arch PF05377.11 CRG92173.1 - 8.9 6.8 41.9 3.8 8.0 1.1 7.8 4 2 4 8 8 8 0 Flagella accessory protein C (FlaC) GPI-anchored PF10342.9 CRG92174.1 - 3.8e-21 75.7 0.9 3.8e-21 75.7 0.9 3.5 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NAR2 PF16974.5 CRG92174.1 - 0.0081 15.6 1.9 0.0081 15.6 1.9 1.9 1 1 0 1 1 1 1 High-affinity nitrate transporter accessory SOG2 PF10428.9 CRG92174.1 - 1.8 7.7 30.2 2.1 7.5 30.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF572 PF04502.13 CRG92174.1 - 4.4 6.8 7.1 5.5 6.5 7.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) BUD22 PF09073.10 CRG92174.1 - 6.6 6.0 9.9 9 5.5 9.9 1.2 1 0 0 1 1 1 0 BUD22 ABC_tran PF00005.27 CRG92175.1 - 7e-51 172.3 0.1 1.6e-27 96.7 0.1 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 CRG92175.1 - 1.6e-26 93.5 35.3 1.2e-23 84.1 16.3 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region AAA_21 PF13304.6 CRG92175.1 - 9.4e-09 35.5 3.7 0.061 13.1 0.0 4.6 4 1 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 CRG92175.1 - 1.3e-08 34.6 5.8 0.0021 17.5 0.1 3.5 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 CRG92175.1 - 7e-06 25.7 1.0 0.042 13.6 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 CRG92175.1 - 1.3e-05 25.3 0.1 0.075 13.1 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 CRG92175.1 - 5.2e-05 23.8 1.1 0.11 13.0 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG92175.1 - 5.7e-05 23.6 0.0 0.068 13.5 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 CRG92175.1 - 0.00012 22.0 2.4 0.02 14.8 0.0 2.7 3 0 0 3 3 2 1 RsgA GTPase AAA_22 PF13401.6 CRG92175.1 - 0.00018 21.8 1.1 0.21 11.8 0.0 2.8 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CRG92175.1 - 0.00019 21.8 0.4 0.035 14.5 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA PF00004.29 CRG92175.1 - 0.00034 21.0 0.1 0.18 12.2 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 CRG92175.1 - 0.0005 19.3 0.1 0.16 11.1 0.0 2.9 2 1 0 2 2 2 1 NB-ARC domain T2SSE PF00437.20 CRG92175.1 - 0.00053 19.1 0.0 0.1 11.6 0.0 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein Dynamin_N PF00350.23 CRG92175.1 - 0.0037 17.3 0.0 0.34 11.0 0.0 2.4 2 0 0 2 2 2 1 Dynamin family AAA_7 PF12775.7 CRG92175.1 - 0.0052 16.3 0.2 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_15 PF13175.6 CRG92175.1 - 0.0069 16.1 0.2 1.8 8.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 CRG92175.1 - 0.0083 15.7 0.0 0.16 11.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 CRG92175.1 - 0.0099 15.6 0.2 0.6 9.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 CRG92175.1 - 0.014 15.6 0.1 9.8 6.4 0.0 3.3 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Adeno_IVa2 PF02456.15 CRG92175.1 - 0.016 14.0 0.2 0.11 11.3 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein cobW PF02492.19 CRG92175.1 - 0.016 14.8 0.5 0.32 10.5 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 CRG92175.1 - 0.018 14.8 0.5 1.4 8.6 0.1 2.6 2 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 CRG92175.1 - 0.019 14.9 0.8 4.2 7.2 0.1 2.7 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 CRG92175.1 - 0.024 14.6 0.1 4.7 7.2 0.0 3.6 5 0 0 5 5 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 CRG92175.1 - 0.025 14.7 0.1 1.3 9.2 0.0 3.3 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 CRG92175.1 - 0.03 14.3 0.0 0.38 10.6 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 CRG92175.1 - 0.037 14.1 0.0 0.18 11.8 0.0 2.3 2 0 0 2 2 1 0 AAA domain Zeta_toxin PF06414.12 CRG92175.1 - 0.043 13.1 0.1 2.1 7.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 CRG92175.1 - 0.047 14.2 0.0 8.5 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 CRG92175.1 - 0.049 14.0 0.1 0.99 9.7 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 CRG92175.1 - 0.049 12.8 0.2 7 5.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_ATPase PF09818.9 CRG92175.1 - 0.056 12.2 1.7 0.14 11.0 0.1 2.3 3 0 0 3 3 3 0 Predicted ATPase of the ABC class UCR_UQCRX_QCR9 PF05365.12 CRG92175.1 - 0.064 13.2 1.1 0.2 11.6 1.1 1.9 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Viral_helicase1 PF01443.18 CRG92175.1 - 0.098 12.4 0.5 1.1 9.0 0.0 2.4 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 CRG92175.1 - 0.11 11.5 0.1 1.9 7.4 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_ab PF00006.25 CRG92175.1 - 0.11 12.1 0.3 4.5 6.9 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain IstB_IS21 PF01695.17 CRG92175.1 - 0.12 12.1 3.1 34 4.1 0.2 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein NACHT PF05729.12 CRG92175.1 - 0.12 12.3 1.3 1.7 8.5 0.1 2.5 2 0 0 2 2 2 0 NACHT domain SbcCD_C PF13558.6 CRG92175.1 - 0.13 12.5 0.0 24 5.2 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PduV-EutP PF10662.9 CRG92175.1 - 0.13 12.0 0.3 1.8 8.3 0.0 2.7 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 CRG92175.1 - 0.18 11.7 0.1 0.6 10.0 0.1 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain DUF87 PF01935.17 CRG92175.1 - 0.21 11.6 3.0 0.28 11.3 0.3 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain Condensation PF00668.20 CRG92177.1 - 0 1331.6 3.9 1.3e-55 188.9 0.0 12.1 11 2 0 11 11 11 11 Condensation domain AMP-binding PF00501.28 CRG92177.1 - 0 1240.6 0.0 2.4e-78 263.6 0.0 5.2 5 0 0 5 5 5 5 AMP-binding enzyme PP-binding PF00550.25 CRG92177.1 - 2.5e-78 258.4 10.8 3.3e-12 46.6 0.0 8.0 7 0 0 7 7 7 7 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG92177.1 - 4.3e-13 50.1 0.0 0.057 14.4 0.0 5.9 5 0 0 5 5 5 4 AMP-binding enzyme C-terminal domain Transferase PF02458.15 CRG92177.1 - 0.0032 16.2 0.2 2.6 6.6 0.1 3.2 2 0 0 2 2 2 2 Transferase family DUF5122 PF17164.4 CRG92177.1 - 4.1 7.8 7.9 71 3.8 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller Pyr_redox_2 PF07992.14 CRG92178.1 - 3.9e-07 29.6 0.0 6.2e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG92178.1 - 9.7e-06 25.6 0.0 8.8e-05 22.5 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 CRG92178.1 - 5.8e-05 22.4 0.0 0.00011 21.5 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG92178.1 - 0.063 12.5 0.0 1.4 8.1 0.0 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase zf-C2H2 PF00096.26 CRG92179.1 - 0.00011 22.5 23.8 0.074 13.5 0.4 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type FOXP-CC PF16159.5 CRG92179.1 - 0.023 15.3 1.5 0.023 15.3 1.5 3.5 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 CRG92180.1 - 8.9e-06 25.6 0.9 8.9e-06 25.6 0.9 3.1 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG92180.1 - 0.001 19.3 7.6 0.0051 17.1 0.3 4.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 CRG92180.1 - 0.0013 19.4 0.7 0.0013 19.4 0.7 7.5 9 0 0 9 9 9 2 C2H2-type zinc finger zf-C2H2 PF00096.26 CRG92180.1 - 0.0028 18.0 0.9 0.0028 18.0 0.9 7.4 8 0 0 8 8 8 3 Zinc finger, C2H2 type zf-met PF12874.7 CRG92180.1 - 0.055 13.9 5.9 0.073 13.5 0.2 4.0 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Carb_kinase PF01256.17 CRG92181.1 - 7.1e-55 186.1 2.3 2e-53 181.4 0.3 2.2 2 1 0 2 2 2 2 Carbohydrate kinase Rubredoxin_C PF18267.1 CRG92181.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Rubredoxin NAD+ reductase C-terminal domain SPT2 PF08243.11 CRG92182.1 - 1.4e-09 38.4 14.8 1.4e-09 38.4 14.8 1.9 2 0 0 2 2 2 1 SPT2 chromatin protein Ribosomal_60s PF00428.19 CRG92183.1 - 1.7e-27 95.8 9.4 2e-27 95.6 9.4 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein UBA_6 PF18039.1 CRG92183.1 - 0.044 13.7 0.2 0.12 12.3 0.2 1.7 1 1 0 1 1 1 0 UBA-like domain Ribosomal_S19 PF00203.21 CRG92184.1 - 5.3e-33 112.7 0.3 7.9e-33 112.2 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S19 zf-MYND PF01753.18 CRG92185.1 - 3.5e-08 33.4 7.1 3.5e-08 33.4 7.1 2.3 2 1 0 2 2 2 1 MYND finger SET PF00856.28 CRG92185.1 - 1.1e-07 32.4 0.0 3.6e-07 30.7 0.0 1.9 2 1 0 2 2 2 1 SET domain CPSase_L_D2 PF02786.17 CRG92186.1 - 2e-109 364.0 0.0 1.2e-84 283.0 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 CRG92186.1 - 7.8e-41 139.3 0.0 2.1e-40 137.8 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.13 CRG92186.1 - 1.5e-19 70.4 0.4 3.9e-09 36.3 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 CRG92186.1 - 6.7e-19 68.1 0.0 2.2e-08 33.8 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 CRG92186.1 - 3.4e-10 39.8 0.0 0.0012 18.6 0.0 3.2 3 1 0 3 3 3 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 CRG92186.1 - 2.5e-06 27.1 0.0 0.012 15.1 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain ATP-grasp_3 PF02655.14 CRG92186.1 - 3.9e-05 23.8 0.2 0.17 11.9 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 CRG92186.1 - 0.00012 21.9 0.1 0.072 12.8 0.1 2.5 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 CRG92186.1 - 0.00039 20.1 0.0 0.4 10.3 0.0 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain Epimerase PF01370.21 CRG92186.1 - 0.042 13.3 0.0 0.45 9.9 0.0 2.3 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GSH-S_ATP PF02955.16 CRG92186.1 - 0.1 12.0 0.0 0.27 10.6 0.0 1.7 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain DUF3072 PF11272.8 CRG92187.1 - 0.027 14.4 2.5 0.17 11.8 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) THOC7 PF05615.13 CRG92187.1 - 2.8 8.2 8.8 2.3 8.5 0.0 3.3 3 0 0 3 3 3 0 Tho complex subunit 7 zf-CRD PF17979.1 CRG92188.1 - 0.76 9.9 8.1 8.7 6.4 8.1 2.1 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions DUF4187 PF13821.6 CRG92189.1 - 1.6e-21 75.8 1.2 3.5e-21 74.7 1.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 CRG92189.1 - 3.8e-08 33.1 0.0 5.7e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 G-patch domain Nucleo_P87 PF07267.11 CRG92189.1 - 0.27 10.0 3.2 0.34 9.7 3.2 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CCDC-167 PF15188.6 CRG92189.1 - 3.4 8.1 7.0 0.35 11.2 1.6 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF4615 PF15393.6 CRG92189.1 - 6.3 7.4 7.1 2.3 8.8 2.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4615) COesterase PF00135.28 CRG92190.1 - 8.4e-84 282.3 0.3 1.1e-83 281.9 0.3 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG92190.1 - 6.9e-07 29.3 0.2 3.8e-06 26.9 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Nop14 PF04147.12 CRG92191.1 - 6e-283 941.3 28.0 7.1e-283 941.0 28.0 1.1 1 0 0 1 1 1 1 Nop14-like family PI3K_1B_p101 PF10486.9 CRG92191.1 - 1.3 6.7 5.1 4.1 5.1 5.1 1.7 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF3636 PF12331.8 CRG92192.1 - 0.016 15.1 0.2 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) DNA_pol_phi PF04931.13 CRG92192.1 - 1.4 6.9 5.8 0.58 8.2 3.5 1.4 2 0 0 2 2 2 0 DNA polymerase phi CENP-B_dimeris PF09026.10 CRG92192.1 - 7.2 7.1 13.1 18 5.8 13.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ORC3_N PF07034.11 CRG92193.1 - 9.8e-37 126.8 0.0 2e-34 119.2 0.0 2.3 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 CRG92193.1 - 3.8e-25 88.6 0.4 2.6e-15 56.7 0.0 3.3 2 1 1 3 3 3 2 Origin recognition complex winged helix C-terminal PsiA PF06952.11 CRG92193.1 - 0.088 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 PsiA protein Ins_allergen_rp PF06757.13 CRG92193.1 - 0.14 12.1 2.7 0.88 9.5 0.2 2.5 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification PPR_2 PF13041.6 CRG92194.1 - 1e-05 25.6 0.2 1.5 9.1 0.0 4.7 5 0 0 5 5 5 2 PPR repeat family PPR PF01535.20 CRG92194.1 - 0.034 14.4 0.6 62 4.2 0.0 4.3 3 0 0 3 3 3 0 PPR repeat PPR_3 PF13812.6 CRG92194.1 - 0.15 12.1 0.0 12 6.0 0.0 3.2 3 0 0 3 3 3 0 Pentatricopeptide repeat domain TPD52 PF04201.15 CRG92194.1 - 0.27 10.8 1.9 0.47 10.1 0.1 2.1 2 0 0 2 2 2 0 Tumour protein D52 family Sec66 PF09802.9 CRG92195.1 - 2.7e-80 268.2 0.4 3.4e-80 267.9 0.4 1.1 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 DUF3848 PF12959.7 CRG92195.1 - 0.0025 17.8 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3848) tRNA-synt_1e PF01406.19 CRG92195.1 - 0.088 12.1 0.3 0.11 11.9 0.3 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain AAA PF00004.29 CRG92196.1 - 2.6e-47 160.6 0.0 7.9e-42 142.8 0.0 3.0 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 CRG92196.1 - 2e-09 37.1 0.0 6e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain IstB_IS21 PF01695.17 CRG92196.1 - 2.7e-06 27.3 0.0 8e-06 25.7 0.0 1.8 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 CRG92196.1 - 4.8e-06 27.1 0.2 0.00021 21.7 0.0 3.2 3 1 0 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 CRG92196.1 - 6.4e-06 26.4 0.0 1.6e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 CRG92196.1 - 0.00043 20.3 0.0 0.0015 18.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 CRG92196.1 - 0.0005 20.2 0.0 1 9.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Bromodomain PF00439.25 CRG92196.1 - 0.00069 19.6 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Bromodomain AAA_22 PF13401.6 CRG92196.1 - 0.0042 17.4 0.4 0.12 12.6 0.2 3.2 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 CRG92196.1 - 0.0045 17.4 0.0 0.012 16.0 0.0 1.7 1 0 0 1 1 1 1 RNA helicase AAA_30 PF13604.6 CRG92196.1 - 0.0057 16.4 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 CRG92196.1 - 0.0079 15.8 0.0 0.026 14.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 CRG92196.1 - 0.023 13.9 0.0 0.042 13.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 CRG92196.1 - 0.034 14.7 1.5 0.14 12.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.6 CRG92196.1 - 0.039 14.0 0.0 0.094 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CRG92196.1 - 0.047 13.9 0.4 0.14 12.3 0.0 2.1 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 CRG92196.1 - 0.058 12.8 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 CRG92196.1 - 0.077 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activat PF00158.26 CRG92196.1 - 0.078 12.7 0.0 2.4 7.8 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.27 CRG92196.1 - 0.099 13.2 0.0 1 9.9 0.0 2.7 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 CRG92196.1 - 0.12 11.9 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 CRG92196.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) LapA_dom PF06305.11 CRG92197.1 - 0.19 11.5 2.9 0.12 12.2 1.1 1.5 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain CPSF_A PF03178.15 CRG92198.1 - 2.8e-103 345.6 0.0 1.1e-102 343.7 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region LMBR1 PF04791.16 CRG92199.1 - 4.1e-16 59.0 4.5 4.1e-16 59.0 4.5 2.5 2 1 1 3 3 3 2 LMBR1-like membrane protein Serine_rich PF08824.10 CRG92200.1 - 0.025 14.6 2.5 0.27 11.2 0.7 2.5 2 0 0 2 2 2 0 Serine rich protein interaction domain FOXP-CC PF16159.5 CRG92200.1 - 0.27 11.9 5.6 12 6.6 0.1 3.3 2 1 1 3 3 3 0 FOXP coiled-coil domain CEBP_ZZ PF16366.5 CRG92200.1 - 0.53 10.6 8.3 1.1 9.6 8.3 1.5 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain RRF PF01765.19 CRG92201.1 - 2.1e-44 151.3 7.4 3.7e-44 150.5 7.4 1.4 1 0 0 1 1 1 1 Ribosome recycling factor HisKA_3 PF07730.13 CRG92201.1 - 0.034 14.6 4.1 12 6.5 1.4 3.2 2 1 0 2 2 2 0 Histidine kinase DUF1664 PF07889.12 CRG92201.1 - 0.083 12.9 7.6 0.31 11.1 6.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Apolipoprotein PF01442.18 CRG92201.1 - 0.16 11.9 9.3 0.85 9.5 9.3 2.1 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain WXG100 PF06013.12 CRG92201.1 - 0.16 12.2 5.8 12 6.2 4.2 3.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG HAUS-augmin3 PF14932.6 CRG92201.1 - 0.17 11.4 9.6 5.1 6.6 6.4 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 DUF3391 PF11871.8 CRG92201.1 - 0.49 10.9 9.5 1.9 9.0 4.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) DUF4778 PF16008.5 CRG92201.1 - 0.81 9.7 8.9 0.11 12.6 4.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4778) Syntaxin PF00804.25 CRG92201.1 - 0.99 9.0 9.0 3.3 7.3 9.0 1.9 1 1 0 1 1 1 0 Syntaxin Macoilin PF09726.9 CRG92201.1 - 2 6.9 14.2 0.24 9.9 0.5 2.0 2 0 0 2 2 2 0 Macoilin family YtxH PF12732.7 CRG92201.1 - 7.1 7.2 12.9 1.2e+02 3.3 0.0 3.2 2 1 0 2 2 2 0 YtxH-like protein DUF883 PF05957.13 CRG92201.1 - 7.7 7.2 12.5 65 4.2 9.3 3.1 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Spt20 PF12090.8 CRG92202.1 - 9.5 5.8 11.6 0.35 10.5 5.8 1.6 2 0 0 2 2 2 0 Spt20 family ANAPC_CDC26 PF10471.9 CRG92203.1 - 9e-17 61.7 0.8 1.4e-16 61.1 0.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Fungal_trans PF04082.18 CRG92204.1 - 3.2e-08 32.9 0.0 6.4e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92204.1 - 2.5e-06 27.5 7.9 4.3e-06 26.7 7.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FeS_assembly_P PF01883.19 CRG92205.1 - 5.8e-10 39.2 0.0 1.6e-09 37.8 0.0 1.8 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein GTP_EFTU PF00009.27 CRG92206.1 - 2.8e-47 160.8 0.0 4.1e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 CRG92206.1 - 7.6e-32 110.5 2.2 1.7e-31 109.3 2.2 1.6 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 CRG92206.1 - 7.3e-25 87.1 0.0 1.6e-24 86.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 CRG92206.1 - 1.6e-19 69.7 0.0 4.3e-19 68.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 CRG92206.1 - 1.7e-09 38.0 0.0 5e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 CRG92206.1 - 1.8e-07 31.2 0.2 1.2e-06 28.5 0.0 2.2 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 CRG92206.1 - 5.1e-05 23.3 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Thiolase_N PF00108.23 CRG92207.1 - 7.4e-94 313.9 1.7 7.4e-94 313.9 1.7 1.5 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 CRG92207.1 - 1.7e-44 150.4 2.4 3e-44 149.6 1.6 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 CRG92207.1 - 4.4e-06 26.5 2.5 4.4e-06 26.5 2.5 2.1 2 1 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 CRG92207.1 - 0.0047 16.8 2.6 0.16 11.9 0.2 3.0 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Zip PF02535.22 CRG92208.1 - 6.1e-50 170.3 0.2 7.6e-50 170.0 0.2 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter PsbH PF00737.20 CRG92208.1 - 0.0024 17.6 0.3 0.046 13.4 0.7 2.6 2 0 0 2 2 2 1 Photosystem II 10 kDa phosphoprotein Atg14 PF10186.9 CRG92209.1 - 1.3e-72 244.6 3.4 2.2e-72 243.9 3.4 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 CRG92209.1 - 0.038 12.9 1.3 0.059 12.2 1.3 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting 38 Exonuc_VII_L PF02601.15 CRG92209.1 - 0.046 13.3 3.8 0.088 12.4 3.6 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit HIP1_clath_bdg PF16515.5 CRG92209.1 - 0.058 14.0 1.9 0.17 12.5 1.9 1.8 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CLZ PF16526.5 CRG92209.1 - 0.11 12.9 1.5 0.24 11.8 1.5 1.6 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels GAS PF13851.6 CRG92209.1 - 0.15 11.4 4.9 0.24 10.8 4.9 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TPR_MLP1_2 PF07926.12 CRG92209.1 - 0.18 11.9 5.1 0.42 10.7 5.1 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TMPIT PF07851.13 CRG92209.1 - 0.43 9.8 2.1 0.67 9.1 2.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein HSP70 PF00012.20 CRG92210.1 - 7.7e-226 750.9 7.3 8.6e-226 750.8 7.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 CRG92210.1 - 1.7e-16 59.9 0.2 1.6e-15 56.8 0.1 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 CRG92210.1 - 0.00014 21.6 0.0 0.0003 20.6 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Bromodomain PF00439.25 CRG92211.1 - 6.7e-25 87.0 0.7 3.5e-13 49.4 0.2 2.6 2 1 0 2 2 2 2 Bromodomain CKS PF01111.19 CRG92212.1 - 1.1e-33 115.3 0.7 1.5e-33 114.8 0.7 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Fve PF09259.11 CRG92212.1 - 0.16 12.1 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 Fungal immunomodulatory protein Fve Thioredoxin_4 PF13462.6 CRG92213.1 - 2.2e-07 31.2 0.0 7.2e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 CRG92213.1 - 0.076 12.8 2.8 2.7 7.7 0.2 2.7 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Phage_TAC_6 PF09550.10 CRG92213.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC DUF3844 PF12955.7 CRG92215.1 - 1.1e-34 118.7 4.6 1.1e-34 118.7 4.6 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3844) Pkip-1 PF06878.11 CRG92215.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Pkip-1 protein zf-RING_2 PF13639.6 CRG92216.1 - 1.6e-12 47.6 6.4 2.5e-12 46.9 6.4 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG92216.1 - 8.7e-09 35.1 5.9 1.4e-08 34.4 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 CRG92216.1 - 1.6e-08 34.1 1.0 2.8e-08 33.3 1.0 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 CRG92216.1 - 3.3e-08 33.2 3.6 5.5e-08 32.6 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 CRG92216.1 - 1.5e-06 28.0 3.3 2.5e-06 27.3 3.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 CRG92216.1 - 4.4e-06 26.9 9.7 2.1e-05 24.7 9.7 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 CRG92216.1 - 7.7e-05 22.6 0.9 7.7e-05 22.6 0.9 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 CRG92216.1 - 0.0011 18.8 2.6 0.0018 18.1 2.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 CRG92216.1 - 0.0012 18.8 2.7 0.0034 17.4 2.7 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 CRG92216.1 - 0.016 14.8 3.5 0.027 14.1 3.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 CRG92216.1 - 0.057 13.3 5.7 0.11 12.4 5.7 1.5 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_4 PF15227.6 CRG92216.1 - 0.058 13.6 4.6 0.12 12.6 4.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 CRG92216.1 - 0.076 12.8 6.2 0.13 12.1 6.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain OAD_gamma PF04277.13 CRG92216.1 - 0.15 12.6 0.2 0.86 10.2 0.0 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Prok-RING_4 PF14447.6 CRG92216.1 - 0.23 11.4 5.1 0.5 10.3 5.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RINGv PF12906.7 CRG92216.1 - 0.63 10.2 3.9 1.3 9.2 3.9 1.6 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 CRG92216.1 - 0.64 10.2 3.8 2 8.7 3.8 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Pheromone PF08015.11 CRG92216.1 - 0.95 10.6 0.0 0.95 10.6 0.0 3.5 4 1 0 4 4 2 0 Fungal mating-type pheromone zf-C3H2C3 PF17122.5 CRG92216.1 - 2.5 8.2 6.0 5.3 7.2 6.0 1.6 1 1 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 CRG92216.1 - 4.4 7.3 8.2 0.16 11.9 1.1 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Pro_isomerase PF00160.21 CRG92217.1 - 8.6e-50 169.1 0.7 9.7e-50 168.9 0.7 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD tRNA-synt_2c PF01411.19 CRG92218.1 - 1.8e-216 720.0 0.2 2.9e-216 719.3 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 CRG92218.1 - 3e-17 62.4 0.7 6.4e-17 61.4 0.7 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 CRG92218.1 - 2.1e-15 57.3 1.2 2.1e-15 57.3 1.2 2.2 2 0 0 2 2 2 1 DHHA1 domain DUF2670 PF10875.8 CRG92218.1 - 0.15 12.2 0.2 0.38 10.9 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) DUF4690 PF15756.5 CRG92219.1 - 7.1e-06 26.5 3.8 7.1e-06 26.5 3.8 2.3 2 0 0 2 2 2 1 Small Novel Rich in Cartilage TMEM154 PF15102.6 CRG92219.1 - 0.0021 18.0 2.7 0.0021 18.0 1.1 1.8 1 1 0 1 1 1 1 TMEM154 protein family Amnionless PF14828.6 CRG92219.1 - 0.0041 16.0 0.0 0.0075 15.1 0.0 1.4 1 0 0 1 1 1 1 Amnionless Glycophorin_A PF01102.18 CRG92219.1 - 0.012 15.8 2.5 0.012 15.8 2.5 2.1 1 1 1 2 2 2 0 Glycophorin A Podoplanin PF05808.11 CRG92219.1 - 0.013 15.6 9.9 0.024 14.7 9.8 1.5 1 1 0 1 1 1 0 Podoplanin PTP_tm PF18861.1 CRG92219.1 - 0.035 14.1 0.0 0.061 13.3 0.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF5305 PF17231.2 CRG92219.1 - 0.043 13.2 0.9 0.068 12.6 0.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) DUF2207 PF09972.9 CRG92219.1 - 0.058 12.2 0.0 0.078 11.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4366 PF14283.6 CRG92219.1 - 0.069 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Stevor PF17410.2 CRG92219.1 - 0.084 12.4 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Gram_pos_anchor PF00746.21 CRG92219.1 - 0.09 12.7 1.2 0.2 11.6 1.2 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif Nucleoporin_FG2 PF15967.5 CRG92219.1 - 0.43 9.0 21.5 0.52 8.8 21.5 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region DUF5074 PF16819.5 CRG92219.1 - 0.58 10.2 5.5 1.4 9.0 5.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5074) TPPK_C PF12555.8 CRG92219.1 - 2 8.5 5.0 3.5 7.7 5.0 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal MAP65_ASE1 PF03999.12 CRG92219.1 - 2.6 6.7 5.1 3.2 6.3 5.1 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF3752 PF12572.8 CRG92220.1 - 2.2e-34 119.2 12.2 2.2e-34 119.2 12.2 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF3752) DUF3435 PF11917.8 CRG92221.1 - 1.4e-21 77.0 0.0 1.9e-11 43.6 0.0 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF3435) Complex1_51K PF01512.17 CRG92222.1 - 8e-47 158.9 0.0 1.2e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 CRG92222.1 - 1.8e-29 101.6 0.3 3.4e-29 100.7 0.3 1.5 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 CRG92222.1 - 7.6e-09 35.3 0.0 1.9e-08 34.0 0.0 1.8 1 0 0 1 1 1 1 SLBB domain DUF3568 PF12092.8 CRG92222.1 - 0.094 12.8 0.4 0.17 11.9 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) MFS_1 PF07690.16 CRG92223.1 - 3.7e-50 170.8 21.2 3.7e-50 170.8 21.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 CRG92223.1 - 0.046 12.0 7.0 0.018 13.3 2.6 2.2 1 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Terminase_3C PF17288.2 CRG92223.1 - 0.056 13.8 0.1 0.098 13.0 0.1 1.3 1 0 0 1 1 1 0 Terminase RNAseH like domain ESSS PF10183.9 CRG92223.1 - 0.5 10.6 4.5 3.7 7.8 0.3 2.7 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Nup96 PF12110.8 CRG92224.1 - 1.7e-82 276.8 0.2 2.5e-82 276.3 0.2 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 CRG92224.1 - 3e-52 176.7 0.0 4.7e-52 176.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 CRG92224.1 - 1.4e-09 38.7 142.1 5.4e-06 27.2 41.7 10.6 4 2 4 8 8 8 4 Nucleoporin FG repeat region AMP-binding PF00501.28 CRG92225.1 - 2.1e-88 296.8 0.0 2.6e-88 296.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG92225.1 - 2.8e-27 95.5 0.2 2e-25 89.6 0.2 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 CRG92225.1 - 9.3e-17 60.7 0.2 2.5e-16 59.3 0.2 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus GET2 PF08690.10 CRG92226.1 - 1.4e-14 54.5 1.2 5.6e-11 42.7 1.2 2.7 2 1 1 3 3 3 2 GET complex subunit GET2 Microvir_H PF04687.12 CRG92226.1 - 0.18 11.2 0.1 0.59 9.5 0.0 1.7 2 0 0 2 2 2 0 Microvirus H protein (pilot protein) FAP PF07174.11 CRG92226.1 - 1 8.7 15.4 2.4 7.6 13.1 2.3 2 1 0 2 2 2 0 Fibronectin-attachment protein (FAP) C2 PF00168.30 CRG92227.1 - 3.4e-28 98.0 0.0 1e-16 61.1 0.0 2.5 2 0 0 2 2 2 2 C2 domain Aminotran_1_2 PF00155.21 CRG92228.1 - 3.5e-69 233.7 0.0 4e-69 233.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CRG92228.1 - 0.00021 20.0 0.0 0.00034 19.3 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 CRG92228.1 - 0.00023 20.5 0.0 0.00036 19.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 CRG92228.1 - 0.0038 16.6 0.0 0.012 14.9 0.0 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 CRG92228.1 - 0.0067 15.4 0.0 0.018 14.0 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class-V EF-hand_7 PF13499.6 CRG92229.1 - 1.4e-16 60.6 2.5 2.5e-10 40.6 0.2 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 CRG92229.1 - 4e-15 54.1 0.7 1.4e-05 24.3 0.0 3.6 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 CRG92229.1 - 6.9e-14 50.5 4.5 6.5e-06 25.7 0.1 3.8 4 1 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 CRG92229.1 - 4.4e-11 42.5 3.3 1.6e-08 34.3 0.2 2.9 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 CRG92229.1 - 0.0015 17.9 1.1 1.5 8.5 0.1 3.3 3 0 0 3 3 3 2 EF hand DUF3572 PF12096.8 CRG92229.1 - 0.043 14.0 0.0 1 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3572) EF-hand_4 PF12763.7 CRG92229.1 - 0.092 12.7 0.0 0.24 11.3 0.0 1.6 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand EFhand_Ca_insen PF08726.10 CRG92229.1 - 0.15 12.2 0.1 0.56 10.3 0.0 2.0 2 0 0 2 2 2 0 Ca2+ insensitive EF hand Reprolysin_5 PF13688.6 CRG92230.1 - 9.7e-59 198.8 6.9 9.7e-59 198.8 6.9 2.4 2 1 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 CRG92230.1 - 1.3e-50 171.8 2.9 3.3e-50 170.6 2.9 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 CRG92230.1 - 1.3e-46 159.0 3.1 1.3e-46 159.0 3.1 2.2 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 CRG92230.1 - 1.1e-15 58.1 31.3 1.1e-15 58.1 31.3 4.6 3 2 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 CRG92230.1 - 3.3e-11 43.8 0.6 1.2e-10 41.9 0.0 2.4 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 CRG92230.1 - 1.5e-07 31.9 11.4 1.5e-07 31.9 11.4 5.2 1 1 2 3 3 3 1 ADAM cysteine-rich domain Pep_M12B_propep PF01562.19 CRG92230.1 - 0.00084 19.6 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Peptidase_M66 PF10462.9 CRG92230.1 - 0.0069 15.4 0.0 0.016 14.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase M66 IMS PF00817.20 CRG92231.1 - 2.8e-35 121.5 0.0 5.5e-35 120.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 CRG92231.1 - 5.3e-16 59.4 0.1 1.1e-15 58.4 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 CRG92231.1 - 0.049 13.2 0.1 0.098 12.3 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 CRG92231.1 - 0.081 13.3 0.0 0.29 11.5 0.0 2.0 2 0 0 2 2 2 0 IMS family HHH motif DUF3454 PF11936.8 CRG92231.1 - 0.28 11.6 6.2 0.088 13.2 3.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3454) CDC45 PF02724.14 CRG92232.1 - 0.088 11.1 6.0 0.12 10.7 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 CRG92232.1 - 0.51 10.0 4.5 0.97 9.1 4.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF3328 PF11807.8 CRG92233.1 - 1.6e-46 158.9 0.0 1.6e-46 158.9 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3328) Dynamin_M PF01031.20 CRG92234.1 - 0.0086 15.3 0.1 4.7 6.4 0.0 2.5 2 1 0 2 2 2 2 Dynamin central region Baculo_PEP_C PF04513.12 CRG92234.1 - 0.17 11.9 17.7 2.8 8.0 3.2 4.8 4 1 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2718 PF10918.8 CRG92234.1 - 5.9 7.4 5.4 1.1 9.8 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) DUF1449 PF07290.11 CRG92234.1 - 6.4 6.3 8.1 1.6 8.3 0.3 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1449) Ald_Xan_dh_C2 PF02738.18 CRG92235.1 - 3e-203 676.3 2.5 4.3e-203 675.7 2.5 1.2 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 CRG92235.1 - 4.3e-47 160.0 0.0 1e-46 158.8 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase CO_deh_flav_C PF03450.17 CRG92235.1 - 1.9e-32 111.5 0.0 1.8e-31 108.3 0.0 2.5 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Ald_Xan_dh_C PF01315.22 CRG92235.1 - 3.2e-32 111.1 0.0 7.3e-32 110.0 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Fer2_2 PF01799.20 CRG92235.1 - 2e-27 95.0 0.0 4.7e-27 93.8 0.0 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 CRG92235.1 - 2.8e-08 33.6 1.1 8.9e-08 32.0 0.2 2.4 3 0 0 3 3 3 1 2Fe-2S iron-sulfur cluster binding domain HTH_AsnC-type PF13404.6 CRG92235.1 - 0.18 11.7 0.1 16 5.4 0.0 3.0 3 0 0 3 3 3 0 AsnC-type helix-turn-helix domain DIM1 PF02966.16 CRG92237.1 - 4.2e-66 220.7 0.1 4.7e-66 220.6 0.1 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 CRG92237.1 - 0.12 12.4 0.0 0.16 12.0 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin AAA_16 PF13191.6 CRG92238.1 - 2.8e-05 24.6 0.0 5.8e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain PRK PF00485.18 CRG92238.1 - 0.00023 21.0 0.0 0.00035 20.4 0.0 1.4 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 CRG92238.1 - 0.00035 21.1 0.0 0.0018 18.8 0.0 2.1 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 CRG92238.1 - 0.015 15.8 0.0 0.031 14.8 0.0 1.5 1 1 0 1 1 1 0 ABC transporter T2SSE PF00437.20 CRG92238.1 - 0.019 14.0 0.0 0.041 12.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein CPT PF07931.12 CRG92238.1 - 0.028 14.3 0.0 0.072 12.9 0.0 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein KTI12 PF08433.10 CRG92238.1 - 0.097 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 PMBR PF09373.10 CRG92238.1 - 0.1 12.8 0.0 0.5 10.6 0.0 2.1 2 0 0 2 2 2 0 Pseudomurein-binding repeat AAA_28 PF13521.6 CRG92238.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 CRG92238.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase SNF2_N PF00176.23 CRG92239.1 - 1.9e-39 135.4 0.0 1.7e-36 125.7 0.0 2.3 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 CRG92239.1 - 1.3e-07 32.0 0.0 3e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HMG_box PF00505.19 CRG92240.1 - 4.1e-23 81.6 0.8 6.8e-23 80.9 0.8 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 CRG92240.1 - 4.9e-09 36.7 0.4 1.1e-08 35.5 0.4 1.6 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 CRG92240.1 - 0.0091 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box Ribosomal_S6e PF01092.19 CRG92242.1 - 2.2e-43 147.2 3.0 3.5e-42 143.3 0.1 2.7 2 1 0 2 2 2 1 Ribosomal protein S6e Pribosyltran_N PF13793.6 CRG92243.1 - 9.1e-45 151.3 0.8 6.5e-43 145.4 0.1 2.4 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 CRG92243.1 - 5.4e-41 140.6 4.8 6.6e-35 120.8 1.0 2.6 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 CRG92243.1 - 1.7e-18 66.6 0.6 2.3e-17 63.0 0.3 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CRG92243.1 - 0.001 18.5 0.2 0.002 17.6 0.2 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF913 PF06025.12 CRG92244.1 - 4.9e-131 437.1 0.0 4.9e-131 437.1 0.0 5.5 5 1 0 5 5 5 2 Domain of Unknown Function (DUF913) DUF908 PF06012.12 CRG92244.1 - 2.3e-108 362.8 9.2 2.3e-108 362.8 9.2 3.3 5 0 0 5 5 5 1 Domain of Unknown Function (DUF908) HECT PF00632.25 CRG92244.1 - 6.7e-94 314.8 0.0 1.2e-93 314.0 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 CRG92244.1 - 1.2e-31 107.2 22.5 2.6e-11 42.6 2.0 4.2 3 0 0 3 3 3 3 Ubiquitin binding region Glyco_transf_34 PF05637.12 CRG92245.1 - 1.2e-52 179.1 0.0 1.6e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Steroid_dh PF02544.16 CRG92245.1 - 6.5e-29 100.9 0.3 1.2e-28 100.0 0.3 1.4 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 CRG92245.1 - 0.00086 19.7 0.1 0.0022 18.3 0.1 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 CRG92245.1 - 0.0034 16.9 0.1 0.0058 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Ribosomal_L28 PF00830.19 CRG92246.1 - 3e-16 59.3 1.5 6.6e-16 58.3 1.5 1.5 1 0 0 1 1 1 1 Ribosomal L28 family DUF5387 PF17361.2 CRG92246.1 - 0.0018 18.0 0.0 0.0027 17.4 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5387) TIP49 PF06068.13 CRG92247.1 - 1.7e-163 543.9 0.0 2e-163 543.6 0.0 1.0 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 CRG92247.1 - 1.2e-21 76.6 0.0 6.8e-21 74.2 0.0 2.2 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 CRG92247.1 - 2.6e-10 40.8 0.2 3.5e-07 30.7 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CRG92247.1 - 1.1e-09 38.2 0.1 2.1e-06 27.6 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 CRG92247.1 - 1.6e-05 25.2 0.1 0.066 13.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 CRG92247.1 - 0.00041 20.8 0.3 0.0048 17.3 0.3 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 CRG92247.1 - 0.00056 20.3 1.7 0.068 13.5 0.4 2.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CRG92247.1 - 0.0013 18.7 0.1 0.19 11.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 CRG92247.1 - 0.0024 18.1 0.1 0.0048 17.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CRG92247.1 - 0.0046 16.7 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 CRG92247.1 - 0.0061 15.9 0.2 0.014 14.7 0.2 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 CRG92247.1 - 0.0075 15.9 0.1 0.019 14.5 0.1 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CRG92247.1 - 0.025 14.0 0.2 0.81 9.0 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 CRG92247.1 - 0.048 12.9 0.0 0.076 12.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 CRG92247.1 - 0.055 13.2 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 CRG92247.1 - 0.069 12.5 0.6 0.15 11.3 0.1 1.7 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 CRG92247.1 - 0.081 13.5 0.1 0.35 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain DnaB_C PF03796.15 CRG92247.1 - 0.11 11.9 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_7 PF12775.7 CRG92247.1 - 0.13 11.8 0.3 0.44 10.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region V-SNARE PF05008.15 CRG92248.1 - 1.8e-21 76.3 5.1 3.9e-21 75.2 5.1 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 CRG92248.1 - 9.4e-16 57.9 2.6 9.4e-16 57.9 2.6 2.1 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Asp PF00026.23 CRG92248.1 - 1.9e-15 57.1 0.0 1.2e-14 54.5 0.0 2.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease DUF1542 PF07564.11 CRG92248.1 - 2 8.6 4.3 5.9 7.1 4.3 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) DUF2407_C PF13373.6 CRG92249.1 - 3e-43 147.3 0.1 4.9e-43 146.7 0.1 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 CRG92249.1 - 3.6e-34 117.4 0.3 6.7e-34 116.6 0.0 1.6 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 CRG92249.1 - 7.2e-05 22.5 0.0 0.00013 21.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 CRG92249.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Fe-S_biosyn PF01521.20 CRG92250.1 - 6.2e-20 71.5 0.0 8.5e-20 71.0 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF1741 PF08427.10 CRG92251.1 - 1.3e-89 299.9 0.5 2e-89 299.3 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1741) MRG PF05712.13 CRG92252.1 - 6.8e-59 198.5 2.6 9.4e-59 198.0 2.6 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 CRG92252.1 - 6.6e-10 38.7 2.0 1.6e-09 37.5 2.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 CRG92252.1 - 0.00098 19.0 1.5 0.0031 17.4 1.5 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PWWP PF00855.17 CRG92252.1 - 0.013 15.8 0.1 0.042 14.3 0.1 1.8 1 0 0 1 1 1 0 PWWP domain Cnl2_NKP2 PF09447.10 CRG92253.1 - 4.9e-27 93.9 1.6 9.5e-27 92.9 1.2 1.7 2 0 0 2 2 2 1 Cnl2/NKP2 family protein V-ATPase_G_2 PF16999.5 CRG92253.1 - 0.01 16.2 0.4 3.2 8.2 0.0 2.1 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit Zw10 PF06248.13 CRG92253.1 - 0.094 11.3 0.4 0.26 9.8 0.1 1.7 2 0 0 2 2 2 0 Centromere/kinetochore Zw10 DUF5082 PF16888.5 CRG92253.1 - 0.17 12.2 0.3 0.17 12.2 0.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF883 PF05957.13 CRG92253.1 - 0.19 12.3 1.9 7 7.3 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Ctf8 PF09696.10 CRG92255.1 - 2.5e-44 151.1 0.0 3.1e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Ctf8 RabGAP-TBC PF00566.18 CRG92256.1 - 2.2e-51 174.6 0.1 2.2e-51 174.6 0.1 2.8 2 1 0 2 2 2 1 Rab-GTPase-TBC domain PspB PF06667.12 CRG92256.1 - 0.066 13.3 1.9 0.26 11.4 1.9 2.0 1 0 0 1 1 1 0 Phage shock protein B Mago_nashi PF02792.14 CRG92256.1 - 3.8 7.6 7.4 0.31 11.1 0.3 2.2 1 1 1 2 2 2 0 Mago nashi protein TolA_bind_tri PF16331.5 CRG92256.1 - 4.7 7.4 17.3 0.14 12.3 6.6 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation Cnn_1N PF07989.11 CRG92256.1 - 5.2 7.3 28.2 0.18 11.9 6.3 3.4 2 1 2 4 4 4 0 Centrosomin N-terminal motif 1 SHE3 PF17078.5 CRG92256.1 - 5.7 6.6 21.0 24 4.6 20.9 1.9 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF1616 PF07760.11 CRG92256.1 - 7.9 5.8 6.7 14 5.0 6.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) p450 PF00067.22 CRG92257.1 - 4.1e-61 207.1 0.0 4.8e-61 206.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PPTA PF01239.22 CRG92258.1 - 3.7e-35 118.6 10.4 1.7e-07 30.7 0.8 5.4 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat YkyA PF10368.9 CRG92258.1 - 0.11 12.1 11.0 0.57 9.8 1.9 3.1 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein WD40 PF00400.32 CRG92259.1 - 2.3e-05 25.0 0.3 8.6e-05 23.2 0.3 2.0 1 0 0 1 1 1 1 WD domain, G-beta repeat Utp12 PF04003.12 CRG92261.1 - 2.1e-21 76.2 0.0 3.7e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family KR PF08659.10 CRG92261.1 - 0.089 12.7 3.0 1.2 9.0 0.1 2.8 3 0 0 3 3 3 0 KR domain Bromodomain PF00439.25 CRG92262.1 - 1.4e-40 137.2 0.4 4.7e-21 74.6 0.2 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 CRG92262.1 - 5.5e-19 68.1 1.1 1.7e-18 66.5 1.1 2.0 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DUF3573 PF12097.8 CRG92262.1 - 0.58 8.9 4.3 0.92 8.3 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) HAUS4 PF14735.6 CRG92263.1 - 1.6e-08 34.6 1.6 3.5e-08 33.4 1.6 1.6 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 4 DisA-linker PF10635.9 CRG92263.1 - 0.044 13.5 0.4 0.23 11.2 0.4 2.1 1 1 0 1 1 1 0 DisA bacterial checkpoint controller linker region zf-CSL PF05207.13 CRG92264.1 - 4.2e-22 77.6 0.1 5.5e-22 77.3 0.1 1.2 1 0 0 1 1 1 1 CSL zinc finger Frataxin_Cyay PF01491.16 CRG92265.1 - 8.4e-35 119.1 0.0 1.2e-34 118.6 0.0 1.2 1 0 0 1 1 1 1 Frataxin-like domain AKAP7_NLS PF10469.9 CRG92266.1 - 1.8e-15 57.4 0.0 3.8e-15 56.3 0.0 1.5 2 0 0 2 2 2 1 AKAP7 2'5' RNA ligase-like domain Erythro_esteras PF05139.14 CRG92266.1 - 0.033 14.0 0.0 0.05 13.4 0.0 1.2 1 0 0 1 1 1 0 Erythromycin esterase Sec6 PF06046.13 CRG92267.1 - 5.4e-173 576.5 8.7 7.7e-173 575.9 8.7 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec6 Vps53_N PF04100.12 CRG92267.1 - 0.0029 16.6 7.5 0.079 11.9 1.2 2.6 2 0 0 2 2 2 2 Vps53-like, N-terminal Laminin_II PF06009.12 CRG92267.1 - 0.012 15.7 0.7 0.041 13.9 0.5 2.1 1 1 1 2 2 2 0 Laminin Domain II LprI PF07007.12 CRG92267.1 - 0.52 11.0 0.1 0.52 11.0 0.1 2.8 3 0 0 3 3 3 0 Lysozyme inhibitor LprI Ribosomal_L30 PF00327.20 CRG92268.1 - 7.8e-11 41.7 0.1 1.1e-10 41.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pyridoxal_deC PF00282.19 CRG92269.1 - 4.1e-17 62.0 0.0 5.5e-17 61.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 CRG92269.1 - 9.7e-05 21.5 0.0 0.00045 19.3 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG92269.1 - 0.043 13.1 0.0 0.074 12.3 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family HMGL-like PF00682.19 CRG92270.1 - 8.6e-78 261.5 0.3 1.2e-77 261.0 0.3 1.2 1 0 0 1 1 1 1 HMGL-like PTH2 PF01981.16 CRG92272.1 - 3.2e-41 140.3 0.1 4.1e-41 140.0 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 CENP-B_dimeris PF09026.10 CRG92272.1 - 0.35 11.3 8.0 0.59 10.5 8.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Astro_capsid_p PF12226.8 CRG92272.1 - 0.35 10.0 2.2 0.45 9.6 2.2 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 CRG92272.1 - 0.55 9.5 4.9 0.76 9.0 4.9 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 CRG92272.1 - 1.7 6.6 6.7 2.2 6.3 6.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi SART-1 PF03343.13 CRG92273.1 - 1.3e-189 631.9 68.3 1.5e-189 631.7 68.3 1.0 1 0 0 1 1 1 1 SART-1 family DUF4752 PF15944.5 CRG92273.1 - 0.046 13.8 0.0 0.16 12.1 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) Aminotran_1_2 PF00155.21 CRG92274.1 - 2.7e-91 306.4 0.0 3.1e-91 306.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Hpt PF01627.23 CRG92275.1 - 4.3e-10 39.7 0.0 8.7e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Hpt domain TP6A_N PF04406.14 CRG92275.1 - 0.069 13.2 0.1 0.52 10.3 0.1 2.1 2 0 0 2 2 2 0 Type IIB DNA topoisomerase Ank_2 PF12796.7 CRG92276.1 - 2.8e-46 156.0 0.3 6.4e-16 58.7 0.1 4.8 3 2 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG92276.1 - 3e-35 116.2 0.5 0.0016 18.8 0.0 8.6 8 0 0 8 8 8 7 Ankyrin repeat Ank_4 PF13637.6 CRG92276.1 - 1.6e-31 108.3 3.8 2.7e-06 27.8 0.0 6.1 2 1 5 7 7 7 6 Ankyrin repeats (many copies) Ank PF00023.30 CRG92276.1 - 2.9e-27 93.9 4.0 0.019 15.4 0.1 8.3 8 0 0 8 8 8 7 Ankyrin repeat MCU PF04678.13 CRG92276.1 - 1.4e-25 90.4 0.2 1.4e-25 90.4 0.2 2.3 2 0 0 2 2 2 1 Mitochondrial calcium uniporter Ank_5 PF13857.6 CRG92276.1 - 7e-24 83.6 3.2 0.00019 21.6 0.0 7.2 2 1 5 7 7 7 7 Ankyrin repeats (many copies) DUF1281 PF06924.11 CRG92276.1 - 0.038 13.5 0.9 0.093 12.3 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) p450 PF00067.22 CRG92277.1 - 2.5e-48 165.0 0.0 3.5e-48 164.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 EII-Sor PF03609.14 CRG92278.1 - 0.027 13.9 0.7 0.027 13.9 0.7 2.1 2 0 0 2 2 2 0 PTS system sorbose-specific iic component Abhydrolase_9_N PF15420.6 CRG92278.1 - 0.035 14.1 1.3 0.05 13.6 0.2 1.8 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus MAP17 PF15807.5 CRG92278.1 - 0.13 12.5 1.3 20 5.4 0.1 2.6 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF202 PF02656.15 CRG92278.1 - 1.4 9.4 9.0 3.1 8.3 0.0 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF202) DDDD PF10161.9 CRG92278.1 - 1.9 8.3 4.6 5 7.0 0.0 2.8 3 0 0 3 3 3 0 Putative mitochondrial precursor protein MFS_1 PF07690.16 CRG92279.1 - 7.6e-39 133.6 43.9 2.4e-37 128.7 43.9 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92279.1 - 1.3e-08 34.1 17.9 1.3e-08 34.1 17.9 2.5 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 CRG92279.1 - 2.3e-06 26.3 19.3 4.3e-06 25.4 19.3 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) SPC25 PF06703.11 CRG92279.1 - 1.6 8.5 5.6 2.5 7.9 1.5 2.7 3 0 0 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) KR PF08659.10 CRG92280.1 - 2.6e-54 183.9 0.0 5.3e-54 182.9 0.0 1.6 1 0 0 1 1 1 1 KR domain ketoacyl-synt PF00109.26 CRG92280.1 - 5.3e-52 176.9 0.1 8.6e-52 176.2 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CRG92280.1 - 1.6e-45 156.0 0.0 3e-45 155.1 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 CRG92280.1 - 7.8e-43 146.8 0.0 1.3e-42 146.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 CRG92280.1 - 2.9e-36 124.0 0.0 6.7e-36 122.9 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG92280.1 - 2.5e-18 66.7 0.0 1.1e-17 64.6 0.0 2.2 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG92280.1 - 3.7e-12 46.7 0.0 6.4e-11 42.7 0.0 2.5 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_31 PF13847.6 CRG92280.1 - 5.4e-12 45.8 0.0 1.6e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 CRG92280.1 - 6.6e-11 42.3 0.0 2.6e-10 40.4 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG92280.1 - 2.1e-10 41.8 0.0 1.7e-09 38.8 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_25 PF13649.6 CRG92280.1 - 3.6e-10 40.4 0.0 2e-09 38.0 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92280.1 - 1.4e-09 38.5 0.1 5.7e-09 36.5 0.0 2.2 2 0 0 2 2 1 1 Methyltransferase domain PP-binding PF00550.25 CRG92280.1 - 3.9e-09 36.7 0.0 8.4e-09 35.7 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_23 PF13489.6 CRG92280.1 - 1.6e-08 34.5 0.0 3.8e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 CRG92280.1 - 2.5e-08 33.6 0.0 6.3e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase Ubie_methyltran PF01209.18 CRG92280.1 - 0.00023 20.5 0.0 0.0005 19.5 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 CRG92280.1 - 0.0004 20.2 0.0 0.0009 19.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain SAT PF16073.5 CRG92280.1 - 0.0027 17.5 0.3 0.0065 16.2 0.3 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis ACP_syn_III PF08545.10 CRG92280.1 - 0.0034 17.2 0.4 0.009 15.9 0.4 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 CRG92280.1 - 0.017 14.5 0.1 0.038 13.4 0.1 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Methyltransf_28 PF02636.17 CRG92280.1 - 0.07 12.7 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase adh_short_C2 PF13561.6 CRG92281.1 - 1.3e-32 113.3 0.0 8.5e-32 110.6 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG92281.1 - 1.4e-31 109.5 0.0 4.9e-31 107.7 0.0 1.8 2 1 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 CRG92281.1 - 1.5e-08 34.8 0.1 3.3e-08 33.6 0.1 1.5 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 CRG92281.1 - 0.028 15.0 1.9 0.032 14.8 0.2 1.9 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.6 CRG92281.1 - 0.039 13.9 0.1 0.061 13.2 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Shikimate_DH PF01488.20 CRG92281.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Prenyltrans PF00432.21 CRG92283.1 - 1.2e-31 108.1 24.4 4.6e-08 32.7 0.7 6.6 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 CRG92283.1 - 0.054 12.6 0.0 3.4 6.7 0.0 2.3 1 1 1 2 2 2 0 Squalene-hopene cyclase N-terminal domain Zn_clus PF00172.18 CRG92284.1 - 0.0033 17.5 7.7 0.0072 16.4 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ank_4 PF13637.6 CRG92285.1 - 0.02 15.5 0.0 0.16 12.6 0.0 2.3 2 1 0 2 2 2 0 Ankyrin repeats (many copies) ubiquitin PF00240.23 CRG92286.1 - 4.4e-135 439.7 20.4 3.3e-33 113.3 0.6 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 CRG92286.1 - 6.6e-64 211.7 21.0 2e-15 56.4 0.7 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 CRG92286.1 - 8.1e-23 80.7 10.7 0.00043 20.7 0.1 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 CRG92286.1 - 1.7e-16 59.9 3.0 0.027 14.4 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 CRG92286.1 - 3e-15 56.3 7.7 0.029 14.7 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 CRG92286.1 - 2.1e-14 53.6 2.6 0.12 12.4 0.0 5.0 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 CRG92286.1 - 5.6e-13 49.3 1.4 0.37 11.4 0.0 4.2 1 1 1 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 CRG92286.1 - 5.9e-11 42.5 0.8 0.6 9.9 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_4 PF18036.1 CRG92286.1 - 3.7e-07 30.1 24.0 16 5.6 0.2 8.0 8 0 0 8 8 8 0 Ubiquitin-like domain Methyltrans_RNA PF04452.14 CRG92286.1 - 3.1e-06 26.7 0.5 1.8 7.8 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase DUF3861 PF12977.7 CRG92286.1 - 3.8e-06 27.0 2.5 13 6.1 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function with PDB structure (DUF3861) DUF2870 PF11069.8 CRG92286.1 - 7.1e-06 26.3 0.0 30 5.1 0.0 4.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) ACT_5 PF13710.6 CRG92286.1 - 1.2e-05 25.0 4.7 10 6.1 0.0 4.3 4 0 0 4 4 4 0 ACT domain Big_7 PF17957.1 CRG92286.1 - 4e-05 24.3 0.1 52 4.7 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig domain UDP-g_GGTase PF06427.11 CRG92286.1 - 0.00014 21.9 4.3 7.1 6.8 0.0 4.0 4 0 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 CRG92286.1 - 0.00043 19.8 0.0 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) YcgR_2 PF12945.7 CRG92286.1 - 0.00091 19.3 6.2 29 4.9 0.1 4.3 4 0 0 4 4 4 0 Flagellar protein YcgR DUF493 PF04359.14 CRG92286.1 - 0.003 18.1 0.1 1.4e+02 3.1 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF493) Raf1_HTH PF18579.1 CRG92286.1 - 0.0037 16.9 0.0 1e+02 2.7 0.0 4.1 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain ACT_4 PF13291.6 CRG92286.1 - 0.0052 17.4 1.0 1.4e+02 3.1 0.0 4.2 4 0 0 4 4 4 0 ACT domain ORF11CD3 PF10549.9 CRG92286.1 - 0.0068 16.5 0.0 91 3.3 0.0 4.3 4 0 0 4 4 4 0 ORF11CD3 domain ProRS-C_2 PF09181.10 CRG92286.1 - 0.11 12.7 5.8 1.1e+02 3.1 0.1 4.1 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Baculo_p48 PF04878.13 CRG92286.1 - 0.12 11.2 0.0 61 2.4 0.0 3.0 3 0 0 3 3 3 0 Baculovirus P48 protein Tash_PEST PF07708.11 CRG92286.1 - 0.14 12.4 27.2 6.2 7.1 1.4 4.3 4 0 0 4 4 4 0 Tash protein PEST motif Myosin_N PF02736.19 CRG92286.1 - 0.23 11.3 6.3 1.1e+02 2.8 0.0 5.2 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain HAMP_N3 PF18575.1 CRG92286.1 - 0.23 11.0 1.5 2e+02 1.6 0.0 3.9 4 0 0 4 4 4 0 HAMP N-terminal domain 3 DMA PF03474.14 CRG92286.1 - 0.29 10.8 4.0 1e+02 2.6 0.0 4.1 4 0 0 4 4 4 0 DMRTA motif PI3K_p85B PF02192.16 CRG92286.1 - 1.9 8.3 9.3 96 2.8 0.1 4.2 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain E1-E2_ATPase PF00122.20 CRG92287.1 - 9.3e-41 139.3 11.8 9.6e-33 113.2 0.7 3.0 3 0 0 3 3 3 2 E1-E2 ATPase BRAP2 PF07576.12 CRG92287.1 - 1.7e-33 114.8 0.1 4.4e-33 113.5 0.0 1.7 2 0 0 2 2 1 1 BRCA1-associated protein 2 Cation_ATPase_C PF00689.21 CRG92287.1 - 1.6e-29 102.9 6.7 1.6e-29 102.9 6.7 2.1 2 1 0 2 2 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 CRG92287.1 - 1.2e-21 76.6 0.0 3.1e-21 75.3 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) zf-UBP PF02148.19 CRG92287.1 - 1e-20 73.8 5.1 2.3e-20 72.7 5.1 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Hydrolase PF00702.26 CRG92287.1 - 4.9e-16 59.7 4.8 1.4e-15 58.2 0.7 3.2 2 1 0 2 2 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 CRG92287.1 - 2.1e-09 36.9 0.0 7.7e-09 35.1 0.0 2.0 2 0 0 2 2 1 1 Cation transporter/ATPase, N-terminus zf-RING_2 PF13639.6 CRG92287.1 - 1.2e-07 31.9 9.4 1.2e-07 31.9 9.4 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 CRG92287.1 - 6.3e-05 22.7 9.3 6.3e-05 22.7 9.3 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 CRG92287.1 - 0.00075 19.3 4.9 0.00075 19.3 4.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG92287.1 - 0.0013 18.6 8.7 0.0031 17.4 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Hydrolase_3 PF08282.12 CRG92287.1 - 0.0017 18.1 6.9 0.0061 16.3 0.9 3.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase zf-rbx1 PF12678.7 CRG92287.1 - 0.0017 18.6 6.7 0.0017 18.6 6.7 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 CRG92287.1 - 0.0029 17.3 5.7 0.0029 17.3 5.7 2.6 2 0 0 2 2 2 1 RING-like zinc finger ZapB PF06005.12 CRG92287.1 - 0.0047 17.3 1.9 0.0047 17.3 1.9 2.8 2 1 1 3 3 2 1 Cell division protein ZapB zf-RING_UBOX PF13445.6 CRG92287.1 - 0.0069 16.4 5.9 0.0069 16.4 5.9 2.4 1 1 1 2 2 2 1 RING-type zinc-finger JAKMIP_CC3 PF16034.5 CRG92287.1 - 0.021 14.8 5.3 0.063 13.2 5.3 1.8 1 0 0 1 1 1 0 JAKMIP CC3 domain COG6 PF06419.11 CRG92287.1 - 0.023 12.9 1.2 0.043 12.0 1.2 1.4 1 1 0 1 1 1 0 Conserved oligomeric complex COG6 zf-RING_6 PF14835.6 CRG92287.1 - 0.4 10.6 8.7 0.13 12.2 5.2 1.9 1 1 0 1 1 1 0 zf-RING of BARD1-type protein ALS2CR11 PF15729.5 CRG92287.1 - 0.64 9.1 2.0 1.3 8.0 2.0 1.5 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 zf-ANAPC11 PF12861.7 CRG92287.1 - 1.1 9.4 10.7 0.2 11.7 5.7 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Exonuc_VII_L PF02601.15 CRG92287.1 - 1.2 8.6 5.7 2.5 7.6 5.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit GIT_CC PF16559.5 CRG92287.1 - 2 8.3 6.2 0.82 9.6 2.3 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-RING_5 PF14634.6 CRG92287.1 - 2 8.4 19.4 0.0093 15.9 7.5 2.3 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 CRG92287.1 - 4.7 7.2 19.2 0.086 12.7 8.3 2.9 2 1 1 3 3 2 0 Prokaryotic RING finger family 4 Methyltransf_23 PF13489.6 CRG92288.1 - 6.8e-20 71.5 0.0 1.1e-19 70.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92288.1 - 1.2e-13 51.5 0.0 2.7e-12 47.2 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92288.1 - 1.6e-12 48.0 0.1 3.9e-05 24.3 0.0 2.8 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 CRG92288.1 - 1.6e-11 44.8 0.0 2.1e-10 41.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92288.1 - 4.4e-09 36.3 0.0 2.7e-08 33.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 CRG92288.1 - 0.0001 21.7 0.0 0.0085 15.4 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase CheR PF01739.18 CRG92288.1 - 0.00028 20.4 0.0 0.00051 19.6 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain Methyltransf_32 PF13679.6 CRG92288.1 - 0.024 14.7 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 CRG92288.1 - 0.13 11.8 0.0 5.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 CRG92288.1 - 0.22 10.8 0.0 1.5 8.1 0.0 1.9 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Prp18 PF02840.15 CRG92288.1 - 0.84 9.7 2.4 1.2 9.1 0.4 2.0 2 0 0 2 2 2 0 Prp18 domain zf-C2H2 PF00096.26 CRG92289.1 - 8.9e-13 47.9 28.6 3e-05 24.2 1.7 3.7 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG92289.1 - 2.7e-10 40.2 29.3 1.2e-06 28.7 1.5 5.4 4 1 1 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG92289.1 - 4.6e-09 36.3 19.8 0.0034 18.1 1.3 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 CRG92289.1 - 2.1e-05 24.6 1.4 0.78 10.1 0.1 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 CRG92289.1 - 0.00011 22.5 10.3 0.029 14.8 0.3 3.6 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 CRG92289.1 - 0.016 14.9 0.8 0.016 14.9 0.8 3.1 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-MYST PF17772.1 CRG92289.1 - 0.031 13.9 1.4 4.6 6.9 0.1 3.0 3 0 0 3 3 3 0 MYST family zinc finger domain zf_UBZ PF18439.1 CRG92289.1 - 0.16 11.6 2.4 0.96 9.1 0.2 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger C1_4 PF07975.12 CRG92289.1 - 0.19 12.0 1.9 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain Yippee-Mis18 PF03226.14 CRG92289.1 - 0.23 11.7 0.7 14 5.9 0.2 2.2 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly LIM PF00412.22 CRG92289.1 - 0.38 11.0 2.9 16 5.8 0.1 2.8 2 1 0 2 2 2 0 LIM domain TFIIS_C PF01096.18 CRG92289.1 - 0.43 10.5 0.1 0.43 10.5 0.1 2.9 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) FOXP-CC PF16159.5 CRG92289.1 - 0.89 10.2 11.9 1.4 9.6 0.3 2.8 2 1 0 2 2 2 0 FOXP coiled-coil domain XPA_N PF01286.18 CRG92289.1 - 1.5 8.9 6.8 0.7 10.0 0.5 2.6 3 0 0 3 3 3 0 XPA protein N-terminal DUF2256 PF10013.9 CRG92289.1 - 2 8.6 6.2 20 5.4 0.1 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) DUF4764 PF15961.5 CRG92289.1 - 3.4 6.3 8.7 5.6 5.5 8.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) Zn_ribbon_recom PF13408.6 CRG92289.1 - 4 8.0 6.6 2.8 8.5 3.3 2.2 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-AN1 PF01428.16 CRG92289.1 - 6.6 7.0 9.2 28 5.0 1.2 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger DUF155 PF02582.14 CRG92290.1 - 5.6e-53 179.6 0.0 8.7e-53 179.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 SPX PF03105.19 CRG92290.1 - 0.067 13.1 0.1 0.067 13.1 0.1 1.8 2 0 0 2 2 2 0 SPX domain DUF2561 PF10812.8 CRG92290.1 - 0.15 12.1 0.0 0.41 10.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) DUF775 PF05603.12 CRG92290.1 - 0.16 11.5 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) YjbT PF17089.5 CRG92291.1 - 0.033 14.2 0.3 0.095 12.7 0.3 1.8 1 0 0 1 1 1 0 Uncharacterised protein family Cytochrom_C1 PF02167.15 CRG92291.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C1 family AIRC PF00731.20 CRG92292.1 - 1.2e-59 200.1 1.3 2.7e-59 199.0 1.3 1.6 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 CRG92292.1 - 3.8e-53 179.6 0.0 9.1e-53 178.3 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain PurK_C PF17769.1 CRG92292.1 - 6.4e-18 64.2 0.1 1.4e-17 63.1 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain CPSase_L_D2 PF02786.17 CRG92292.1 - 3.1e-06 26.8 0.2 1e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 CRG92292.1 - 8.7e-06 25.4 0.7 5.6e-05 22.8 0.0 2.5 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus PrpR_N PF06506.11 CRG92292.1 - 1.6e-05 24.6 0.5 0.006 16.2 0.1 3.1 3 0 0 3 3 3 1 Propionate catabolism activator AlaDh_PNT_C PF01262.21 CRG92292.1 - 0.00019 20.8 0.1 0.00046 19.6 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 CRG92292.1 - 0.00089 19.2 1.1 0.0025 17.7 0.3 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 CRG92292.1 - 0.0026 17.1 0.0 0.0052 16.2 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 CRG92292.1 - 0.0043 17.0 1.5 0.029 14.3 0.3 2.3 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 CRG92292.1 - 0.027 14.6 0.1 0.079 13.1 0.1 1.8 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_M15_3 PF08291.11 CRG92292.1 - 0.029 14.5 0.0 3.6 7.7 0.0 3.7 3 1 1 4 4 4 0 Peptidase M15 XdhC_C PF13478.6 CRG92292.1 - 0.037 14.5 0.1 0.47 11.0 0.0 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain F420_oxidored PF03807.17 CRG92292.1 - 0.041 14.5 0.8 0.11 13.0 0.2 2.1 2 0 0 2 2 1 0 NADP oxidoreductase coenzyme F420-dependent NmrA PF05368.13 CRG92292.1 - 0.12 11.9 1.2 0.74 9.3 0.6 2.2 2 0 0 2 2 2 0 NmrA-like family ATP-grasp_3 PF02655.14 CRG92292.1 - 0.12 12.4 0.0 0.44 10.6 0.0 2.0 1 0 0 1 1 1 0 ATP-grasp domain Ago_N_1 PF18351.1 CRG92292.1 - 0.15 12.5 0.0 0.45 11.0 0.0 1.8 1 0 0 1 1 1 0 Fungal Argonaute N-terminal domain PPP4R2 PF09184.11 CRG92293.1 - 1.2e-08 35.0 8.1 4.2e-08 33.1 7.9 1.9 1 1 0 1 1 1 1 PPP4R2 GATA PF00320.27 CRG92294.1 - 1e-15 57.0 5.9 2.1e-15 56.0 5.9 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 CRG92294.1 - 8.6e-13 48.4 0.0 1.8e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 CRG92294.1 - 2.6e-09 37.1 0.0 5.2e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 CRG92294.1 - 5.6e-07 29.8 0.0 1.5e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS_11 PF14598.6 CRG92294.1 - 3.2e-06 27.3 0.0 6.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 PAS domain PAS_4 PF08448.10 CRG92294.1 - 2.2e-05 24.7 0.0 3.8e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 PAS fold Zn-ribbon_8 PF09723.10 CRG92294.1 - 0.0094 16.0 0.1 0.019 15.1 0.1 1.5 1 0 0 1 1 1 1 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 CRG92294.1 - 0.085 12.4 0.6 0.72 9.4 0.1 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding DUF4428 PF14471.6 CRG92294.1 - 0.25 11.3 2.3 0.3 11.0 0.2 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4428) PCI PF01399.27 CRG92295.1 - 2.6e-05 24.7 0.0 5.3e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 CRG92295.1 - 0.00057 19.7 0.8 0.001 18.9 0.8 1.4 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain Pns11_12 PF17464.2 CRG92295.1 - 0.17 11.6 4.7 0.27 10.9 4.7 1.3 1 0 0 1 1 1 0 Non-structural protein 11 and 12 RGS PF00615.19 CRG92296.1 - 1.6e-12 47.7 0.0 2.8e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Bromodomain PF00439.25 CRG92297.1 - 9.4e-24 83.3 0.7 2.1e-23 82.2 0.7 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 CRG92297.1 - 4.7e-08 33.3 0.0 8.3e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 CRG92297.1 - 1e-06 28.7 0.0 1.7e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 CRG92297.1 - 0.0003 21.2 0.1 0.00052 20.4 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ost5 PF05251.12 CRG92298.1 - 1.6e-21 76.3 9.1 1.8e-21 76.2 9.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 CorA PF01544.18 CRG92298.1 - 6.2 6.0 6.5 7 5.9 6.5 1.0 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Rad1 PF02144.16 CRG92299.1 - 6.4e-93 310.8 0.0 7.5e-93 310.6 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 AAA_23 PF13476.6 CRG92300.1 - 1.2e-21 78.1 4.4 1.2e-21 78.1 4.4 7.9 2 2 0 2 2 2 1 AAA domain SMC_N PF02463.19 CRG92300.1 - 1.3e-08 34.6 3.4 1.3e-08 34.6 3.4 3.2 4 1 0 4 4 4 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 CRG92300.1 - 4.3e-06 26.9 0.0 4.3e-06 26.9 0.0 2.4 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Orf78 PF06024.12 CRG92300.1 - 0.022 15.0 0.0 0.022 15.0 0.0 4.0 3 0 0 3 3 3 0 Orf78 (ac78) HHH_8 PF14716.6 CRG92300.1 - 0.061 13.7 2.6 5.9 7.3 0.1 4.1 3 0 0 3 3 3 0 Helix-hairpin-helix domain COesterase PF00135.28 CRG92301.1 - 6.8e-10 38.4 0.0 1.1e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family COesterase PF00135.28 CRG92302.1 - 8.1e-29 100.9 0.0 9.6e-29 100.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 CRG92302.1 - 2.5e-06 27.5 0.0 3.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG92302.1 - 0.00018 21.1 0.0 0.00022 20.8 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 CRG92302.1 - 0.0015 17.4 0.0 0.0019 17.2 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_1 PF00561.20 CRG92302.1 - 0.022 14.4 0.0 0.024 14.3 0.0 1.1 1 0 0 1 1 1 0 alpha/beta hydrolase fold GFO_IDH_MocA PF01408.22 CRG92303.1 - 4e-16 59.9 0.0 6.5e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DDE_Tnp_IS240 PF13610.6 CRG92304.1 - 0.0013 19.0 0.5 0.0016 18.7 0.5 1.2 1 0 0 1 1 1 1 DDE domain SKA2 PF16740.5 CRG92304.1 - 0.0037 17.0 0.8 0.0049 16.6 0.8 1.1 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 HALZ PF02183.18 CRG92304.1 - 0.0053 17.0 2.0 0.0053 17.0 2.0 1.7 2 0 0 2 2 2 1 Homeobox associated leucine zipper DUF4795 PF16043.5 CRG92304.1 - 0.011 15.4 1.7 0.012 15.2 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) COG6 PF06419.11 CRG92304.1 - 0.017 13.4 1.9 0.021 13.0 1.9 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 DUF4735 PF15882.5 CRG92304.1 - 0.023 14.2 0.3 0.032 13.7 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) DUF2968 PF11180.8 CRG92304.1 - 0.023 14.3 1.2 0.034 13.8 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) DUF3740 PF12548.8 CRG92304.1 - 0.034 14.6 1.7 0.057 13.9 1.7 1.4 1 0 0 1 1 1 0 Sulfatase protein Dzip-like_N PF13815.6 CRG92304.1 - 0.035 14.1 0.6 0.042 13.8 0.6 1.1 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal ZapB PF06005.12 CRG92304.1 - 0.038 14.4 5.9 0.059 13.8 5.9 1.3 1 0 0 1 1 1 0 Cell division protein ZapB Sec20 PF03908.13 CRG92304.1 - 0.071 13.0 0.7 0.11 12.5 0.7 1.2 1 0 0 1 1 1 0 Sec20 DASH_Dam1 PF08653.10 CRG92304.1 - 0.1 12.4 2.1 2.8 7.8 0.2 2.2 1 1 1 2 2 2 0 DASH complex subunit Dam1 NYD-SP28_assoc PF14775.6 CRG92304.1 - 1.5 9.0 6.5 1 9.5 3.8 2.1 2 1 0 2 2 2 0 Sperm tail C-terminal domain Aminotran_3 PF00202.21 CRG92305.1 - 5.5e-87 292.1 0.2 6.6e-87 291.8 0.2 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta-prism_lec PF16458.5 CRG92305.1 - 0.072 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Beta-prism lectin Caudo_TAP PF02413.17 CRG92305.1 - 0.13 12.4 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Peptidase_S58 PF03576.14 CRG92306.1 - 8e-91 304.7 0.0 9.5e-91 304.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S58 Ribonuc_L-PSP PF01042.21 CRG92307.1 - 2.2e-21 76.1 0.0 2.5e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP MFS_1 PF07690.16 CRG92308.1 - 5.1e-31 107.9 43.8 5.7e-31 107.7 43.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily ADH_zinc_N PF00107.26 CRG92309.1 - 7.9e-09 35.6 0.1 4.8e-08 33.0 0.0 2.3 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG92309.1 - 8.2e-05 23.7 0.0 0.00028 21.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glyco_hydro_3_C PF01915.22 CRG92310.1 - 4.6e-54 183.5 0.0 9.6e-54 182.4 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 CRG92310.1 - 2.9e-50 171.5 0.0 4.3e-50 170.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 CRG92310.1 - 6.2e-12 45.5 0.0 1.4e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 CRG92310.1 - 2.1e-09 37.4 0.0 3.8e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 PA14 domain Fungal_trans PF04082.18 CRG92311.1 - 1.7e-21 76.5 0.1 2.8e-21 75.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92311.1 - 4.4e-10 39.5 9.7 9.8e-10 38.4 9.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DNA_pol_phi PF04931.13 CRG92311.1 - 0.077 11.1 0.1 0.11 10.5 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sugar_tr PF00083.24 CRG92312.1 - 1.5e-91 307.6 22.4 1.7e-91 307.4 22.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92312.1 - 2.7e-17 62.8 41.6 4.5e-10 39.0 17.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92313.1 - 8.7e-81 272.1 29.3 1e-80 271.9 29.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92313.1 - 1.2e-27 96.8 37.6 1.5e-27 96.5 34.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG92313.1 - 0.00042 18.9 9.7 0.00042 18.9 3.0 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) DSPc PF00782.20 CRG92313.1 - 0.17 11.7 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF5423 PF17461.2 CRG92313.1 - 0.29 10.0 0.6 0.52 9.1 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5423) DUF3483 PF11982.8 CRG92313.1 - 2.2 7.9 11.1 0.038 13.6 3.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3483) MHYT PF03707.16 CRG92313.1 - 5.3 7.3 12.6 0.089 13.0 1.1 3.6 3 1 0 3 3 3 0 Bacterial signalling protein N terminal repeat DAP_B PF07930.12 CRG92314.1 - 9.2e-74 247.4 0.0 1.3e-73 246.9 0.0 1.2 1 0 0 1 1 1 1 D-aminopeptidase, domain B Beta-lactamase PF00144.24 CRG92314.1 - 1.8e-42 145.8 0.0 2.3e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase E1-E2_ATPase PF00122.20 CRG92315.1 - 4.6e-49 166.4 0.5 1.7e-48 164.5 0.5 2.0 1 0 0 1 1 1 1 E1-E2 ATPase HMA PF00403.26 CRG92315.1 - 8.2e-45 151.1 1.6 1.9e-11 44.2 0.0 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 CRG92315.1 - 1.1e-32 114.0 0.9 2.5e-32 112.9 0.9 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CRG92315.1 - 1.6e-06 28.0 1.6 6.7e-05 22.7 0.4 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase MARVEL PF01284.23 CRG92316.1 - 0.042 13.9 1.3 0.069 13.2 1.3 1.4 1 0 0 1 1 1 0 Membrane-associating domain Trp_oprn_chp PF09534.10 CRG92316.1 - 0.13 12.1 0.0 0.36 10.6 0.0 1.7 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) NAD_binding_6 PF08030.12 CRG92317.1 - 4.2e-06 26.9 0.0 0.0051 16.9 0.0 2.1 2 0 0 2 2 2 2 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 CRG92317.1 - 2.5e-05 24.9 0.0 0.4 11.3 0.0 2.5 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain HAD PF12710.7 CRG92318.1 - 8.1e-21 75.3 0.0 1.5e-20 74.4 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Metallophos PF00149.28 CRG92318.1 - 4.1e-17 63.4 0.3 9.4e-17 62.2 0.3 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG92318.1 - 5.8e-05 23.3 0.1 0.0015 18.8 0.1 2.5 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain Put_Phosphatase PF06888.12 CRG92318.1 - 0.042 13.2 0.0 2.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Putative Phosphatase GCD14 PF08704.10 CRG92319.1 - 1.6e-06 28.0 1.0 0.0055 16.4 0.0 2.7 2 1 1 3 3 3 2 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 CRG92319.1 - 0.0022 17.8 0.3 0.0073 16.1 0.1 2.0 2 0 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_25 PF13649.6 CRG92319.1 - 0.0024 18.6 0.0 3.7 8.3 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_24 PF13578.6 CRG92319.1 - 0.011 16.7 0.4 0.097 13.7 0.4 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92319.1 - 0.045 13.6 0.0 13 5.6 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain Androgen_recep PF02166.16 CRG92319.1 - 3.3 6.5 7.0 6.3 5.5 7.0 1.4 1 0 0 1 1 1 0 Androgen receptor Hydrolase_4 PF12146.8 CRG92320.1 - 7.1e-49 166.2 0.1 8.6e-49 165.9 0.1 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 CRG92320.1 - 2.3e-14 54.6 3.0 2.8e-14 54.3 3.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG92320.1 - 5e-14 52.6 0.1 2.7e-12 46.9 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 CRG92320.1 - 1.1e-05 25.1 0.2 0.0036 16.8 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 CRG92320.1 - 0.0089 15.7 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 CRG92320.1 - 0.021 14.4 0.0 0.08 12.5 0.0 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 CRG92320.1 - 0.025 14.4 0.0 11 5.8 0.0 3.2 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Exo_endo_phos PF03372.23 CRG92321.1 - 5.4e-19 68.6 0.0 3.1e-18 66.2 0.0 2.2 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 CRG92321.1 - 3.2e-12 46.5 3.3 1.3e-07 31.8 2.2 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG92321.1 - 4.6e-09 35.9 4.2 5.8e-09 35.6 3.1 1.8 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 CRG92321.1 - 0.048 14.2 5.8 2.1 9.2 0.0 4.3 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 CRG92321.1 - 0.39 10.9 2.5 0.8 9.9 0.3 2.6 3 0 0 3 3 3 0 Leucine Rich repeat Methyltransf_25 PF13649.6 CRG92322.1 - 2.3e-12 47.5 0.0 4e-12 46.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92322.1 - 1.4e-08 35.2 0.0 2.7e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG92322.1 - 5.6e-05 23.0 0.0 0.00018 21.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92322.1 - 0.00014 21.7 0.0 0.00027 20.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG92322.1 - 0.00061 20.5 0.0 0.0012 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain 4HBT_2 PF13279.6 CRG92323.1 - 9.6e-25 87.4 0.0 1.5e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 CRG92323.1 - 3.9e-05 23.9 0.0 0.00016 21.9 0.0 2.1 1 1 0 1 1 1 1 Thioesterase superfamily MHC_I PF00129.18 CRG92323.1 - 0.056 13.0 0.2 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Asp_Glu_race PF01177.22 CRG92324.1 - 6.5e-31 107.9 0.0 7.6e-31 107.7 0.0 1.0 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase GDE_C PF06202.14 CRG92325.1 - 0.1 11.5 1.6 0.65 8.9 1.3 2.1 2 0 0 2 2 2 0 Amylo-alpha-1,6-glucosidase DUF1612 PF07756.12 CRG92325.1 - 1.5 9.1 9.6 0.65 10.3 2.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1612) Flavin_Reduct PF01613.18 CRG92326.1 - 1e-16 61.4 0.3 2.4e-16 60.2 0.3 1.6 1 1 0 1 1 1 1 Flavin reductase like domain EVC2_like PF12297.8 CRG92327.1 - 0.013 14.2 4.1 0.017 13.9 4.1 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Vps5 PF09325.10 CRG92328.1 - 1.8e-87 292.8 2.5 2.6e-87 292.3 2.5 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 CRG92328.1 - 1.5e-24 86.1 0.1 3.5e-24 85.0 0.1 1.7 1 0 0 1 1 1 1 PX domain BAR_3 PF16746.5 CRG92328.1 - 0.0021 17.8 5.3 0.037 13.7 1.5 2.4 1 1 1 2 2 2 1 BAR domain of APPL family DUF3450 PF11932.8 CRG92328.1 - 0.36 10.1 7.2 0.11 11.8 3.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) ADIP PF11559.8 CRG92328.1 - 0.5 10.4 8.6 0.47 10.5 7.1 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TFIIA PF03153.13 CRG92328.1 - 1.4 8.9 0.0 1.4 8.9 0.0 3.0 2 1 1 3 3 3 0 Transcription factor IIA, alpha/beta subunit OAD_gamma PF04277.13 CRG92328.1 - 3.8 8.2 13.1 0.39 11.3 7.4 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Aldolase_II PF00596.21 CRG92329.1 - 1.1e-43 149.3 0.0 1.4e-43 149.0 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Calreticulin PF00262.18 CRG92330.1 - 4.7e-169 562.0 16.7 6.7e-169 561.5 16.7 1.2 1 0 0 1 1 1 1 Calreticulin family GFA PF04828.14 CRG92331.1 - 2.1e-21 76.1 0.2 3.5e-21 75.3 0.2 1.4 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme NOB1_Zn_bind PF08772.11 CRG92331.1 - 0.023 14.9 1.7 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Sugar_tr PF00083.24 CRG92333.1 - 2.6e-96 323.2 26.1 3e-96 323.0 26.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92333.1 - 1.7e-20 73.2 62.3 3.1e-19 69.1 29.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_19 PF14559.6 CRG92333.1 - 0.12 12.9 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Plasmid_stab_B PF10784.9 CRG92333.1 - 0.13 12.2 0.4 0.52 10.2 0.3 2.1 2 1 1 3 3 3 0 Plasmid stability protein Cyclase PF04199.13 CRG92334.1 - 5.1e-12 46.2 0.0 6.8e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Putative cyclase Aldedh PF00171.22 CRG92335.1 - 9.7e-136 452.9 0.3 1.2e-135 452.7 0.3 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 CRG92335.1 - 0.015 14.4 0.0 0.022 13.8 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) PsbH PF00737.20 CRG92335.1 - 0.13 12.0 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein Dynamitin PF04912.14 CRG92337.1 - 2.8e-74 250.8 16.8 1.1e-37 130.3 8.7 2.0 2 0 0 2 2 2 2 Dynamitin SlyX PF04102.12 CRG92337.1 - 0.013 16.1 5.5 0.29 11.8 0.5 4.1 4 0 0 4 4 4 0 SlyX Laminin_II PF06009.12 CRG92337.1 - 0.021 14.8 0.3 0.021 14.8 0.3 3.5 2 1 2 4 4 4 0 Laminin Domain II DivIC PF04977.15 CRG92337.1 - 0.03 14.1 13.1 0.1 12.4 0.9 3.6 3 0 0 3 3 3 0 Septum formation initiator DNA_pol3_tau_4 PF12168.8 CRG92337.1 - 0.031 14.8 0.3 0.031 14.8 0.3 3.3 4 1 0 4 4 3 0 DNA polymerase III subunits tau domain IV DnaB-binding FapA PF03961.13 CRG92337.1 - 0.073 11.7 3.5 0.19 10.3 0.3 2.3 2 1 0 2 2 2 0 Flagellar Assembly Protein A TPR_MLP1_2 PF07926.12 CRG92337.1 - 1.1 9.4 18.1 0.47 10.5 1.0 3.7 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 CRG92337.1 - 1.1 9.3 16.4 0.63 10.1 1.2 3.7 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.14 CRG92337.1 - 2.3 8.0 7.9 1.7 8.4 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF724) APG6_N PF17675.1 CRG92337.1 - 3.4 8.2 18.7 4.4 7.8 3.7 3.0 2 1 1 3 3 3 0 Apg6 coiled-coil region XRCC4 PF06632.12 CRG92337.1 - 5 5.9 16.8 3.3 6.5 3.3 2.3 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Snapin_Pallidin PF14712.6 CRG92337.1 - 7.3 7.1 7.5 3 8.3 0.4 3.4 4 1 0 4 4 4 0 Snapin/Pallidin Prefoldin_2 PF01920.20 CRG92337.1 - 8.1 6.5 10.9 1.7 8.6 0.7 3.0 3 0 0 3 3 3 0 Prefoldin subunit Rho_Binding PF08912.11 CRG92337.1 - 9.8 7.1 9.9 1.8 9.5 0.1 3.4 3 1 0 3 3 3 0 Rho Binding Pyr_redox_2 PF07992.14 CRG92338.1 - 5.6e-50 170.2 0.2 7.2e-50 169.9 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG92338.1 - 6.9e-17 61.6 0.1 3.3e-15 56.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 CRG92338.1 - 3.8e-15 56.2 0.2 1.3e-12 48.1 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG92338.1 - 4.3e-05 22.9 0.4 0.00011 21.5 0.1 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 CRG92338.1 - 8.5e-05 22.9 0.2 0.031 14.7 0.0 2.8 2 1 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 CRG92338.1 - 0.00078 19.6 0.5 0.18 12.0 0.2 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 CRG92338.1 - 0.0033 16.8 0.4 0.12 11.7 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 CRG92338.1 - 0.0051 16.0 0.0 0.38 9.8 0.0 2.9 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG92338.1 - 0.0053 16.4 5.3 1.4 8.4 0.0 3.5 2 2 1 4 4 4 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CRG92338.1 - 0.0073 15.6 1.2 2.4 7.3 0.0 3.0 2 1 1 3 3 3 1 FAD binding domain GIDA PF01134.22 CRG92338.1 - 0.01 15.0 5.0 0.49 9.4 0.1 4.0 3 2 1 4 4 4 0 Glucose inhibited division protein A Shikimate_DH PF01488.20 CRG92338.1 - 0.044 13.9 0.1 14 5.7 0.0 3.0 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Trp_halogenase PF04820.14 CRG92338.1 - 0.076 11.9 0.1 0.5 9.2 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase GTP_EFTU PF00009.27 CRG92338.1 - 0.17 11.4 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain FAD_binding_2 PF00890.24 CRG92338.1 - 1 8.4 7.2 0.59 9.1 0.8 3.1 3 1 1 4 4 4 0 FAD binding domain PhoD PF09423.10 CRG92339.1 - 0.00055 19.1 0.0 0.004 16.2 0.0 2.2 1 1 0 1 1 1 1 PhoD-like phosphatase Cluap1 PF10234.9 CRG92339.1 - 0.16 11.4 2.1 0.32 10.4 2.1 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 Peptidase_S8 PF00082.22 CRG92340.1 - 1e-39 136.6 0.3 1.4e-39 136.1 0.3 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 CRG92340.1 - 8.3e-27 93.0 0.7 2e-26 91.8 0.7 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain PX PF00787.24 CRG92341.1 - 1.8e-18 66.5 0.1 3.8e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 CRG92341.1 - 7.8e-15 55.1 6.4 3.2e-07 30.2 1.3 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 CRG92341.1 - 0.001 18.8 3.6 0.064 12.9 3.6 2.3 1 1 0 1 1 1 1 BAR domain Sec34 PF04136.15 CRG92341.1 - 0.05 13.5 0.3 0.1 12.5 0.1 1.6 2 0 0 2 2 2 0 Sec34-like family DUF1664 PF07889.12 CRG92341.1 - 0.52 10.4 1.9 12 5.9 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.15 CRG92341.1 - 3.1 7.6 5.1 12 5.8 0.2 2.5 2 0 0 2 2 2 0 Septum formation initiator ADIP PF11559.8 CRG92341.1 - 4 7.5 6.6 17 5.5 0.4 2.9 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding BLUF PF04940.12 CRG92342.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Sensors of blue-light using FAD FAD_binding_3 PF01494.19 CRG92344.1 - 1.4e-19 70.6 0.0 2.3e-10 40.3 0.0 3.1 2 1 0 2 2 2 2 FAD binding domain SE PF08491.10 CRG92344.1 - 4.6e-07 29.2 0.0 7.5e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Lycopene_cycl PF05834.12 CRG92344.1 - 0.00011 21.4 0.1 0.00041 19.5 0.0 1.8 2 0 0 2 2 2 1 Lycopene cyclase protein Trp_halogenase PF04820.14 CRG92344.1 - 0.00055 18.9 0.1 0.0073 15.2 0.0 2.3 3 0 0 3 3 3 1 Tryptophan halogenase NAD_binding_8 PF13450.6 CRG92344.1 - 0.00099 19.3 0.2 0.0025 18.0 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG92344.1 - 0.006 16.2 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG92344.1 - 0.0075 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG92344.1 - 0.032 14.2 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 CRG92344.1 - 0.081 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 CRG92344.1 - 0.083 12.0 0.2 0.14 11.2 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 CRG92344.1 - 0.094 11.9 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Thi4 family tRNA-synt_His PF13393.6 CRG92345.1 - 9.3e-35 120.4 0.0 1.2e-28 100.3 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 CRG92345.1 - 4.7e-13 49.1 0.0 1.1e-12 48.0 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 CRG92345.1 - 7.8e-05 22.7 0.0 0.00029 20.8 0.0 2.1 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 CRG92345.1 - 0.004 16.7 0.0 0.0066 16.0 0.0 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs UCH PF00443.29 CRG92346.1 - 3.3e-57 193.9 0.1 6.3e-57 193.0 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 CRG92346.1 - 3.4e-28 99.2 1.8 2.2e-20 73.5 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 CRG92346.1 - 0.0012 18.4 3.3 0.032 13.7 2.2 2.8 3 0 0 3 3 3 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF3292 PF11696.8 CRG92346.1 - 5.6 5.2 9.2 12 4.2 9.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) CPSF100_C PF13299.6 CRG92346.1 - 9 6.4 11.7 14 5.8 6.7 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Yos1 PF08571.10 CRG92347.1 - 1.3e-35 121.5 0.3 1.5e-35 121.3 0.3 1.0 1 0 0 1 1 1 1 Yos1-like Glyco_transf_22 PF03901.17 CRG92348.1 - 4.5e-45 154.6 16.6 6.1e-45 154.2 16.6 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SH3_12 PF18129.1 CRG92348.1 - 0.16 12.1 0.2 0.34 11.1 0.2 1.4 1 0 0 1 1 1 0 Xrn1 SH3-like domain Amino_oxidase PF01593.24 CRG92349.1 - 2.7e-83 280.8 0.1 1.5e-81 275.0 0.1 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 CRG92349.1 - 1.8e-13 50.6 0.0 4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain NAD_binding_8 PF13450.6 CRG92349.1 - 4.3e-09 36.5 0.0 1.2e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG92349.1 - 0.00036 20.2 2.1 0.00096 18.8 2.1 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG92349.1 - 0.0063 15.8 0.6 0.026 13.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HMG_box PF00505.19 CRG92349.1 - 0.013 15.9 1.4 0.027 14.9 1.4 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box NAD_binding_9 PF13454.6 CRG92349.1 - 0.022 14.8 0.1 0.12 12.3 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Thi4 PF01946.17 CRG92349.1 - 0.043 13.1 0.1 0.076 12.2 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CRG92349.1 - 0.099 11.9 0.3 0.71 9.1 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG92349.1 - 0.3 10.1 5.3 0.36 9.9 0.2 2.7 3 0 0 3 3 3 0 FAD binding domain CoaE PF01121.20 CRG92350.1 - 2.1e-43 148.1 0.0 3e-43 147.6 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 CRG92350.1 - 0.002 18.7 0.7 0.39 11.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 CRG92350.1 - 0.006 16.7 0.0 0.071 13.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain Alanine_zipper PF11839.8 CRG92350.1 - 2.3 8.6 6.8 0.54 10.7 2.9 1.9 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein Aldedh PF00171.22 CRG92351.1 - 1.3e-113 380.0 0.3 1.5e-113 379.7 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 CRG92351.1 - 0.042 13.3 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) MCRA PF06100.11 CRG92352.1 - 8.2e-158 526.3 0.0 4.3e-144 481.0 0.0 2.0 1 1 1 2 2 2 2 MCRA family FAD_binding_2 PF00890.24 CRG92352.1 - 0.17 10.9 0.0 0.3 10.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain PNP_UDP_1 PF01048.20 CRG92353.1 - 9.9e-14 51.2 0.4 5.3e-13 48.8 0.4 2.0 1 1 0 1 1 1 1 Phosphorylase superfamily Ank_2 PF12796.7 CRG92353.1 - 1.5e-09 38.3 0.0 4.1e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 CRG92353.1 - 5.8e-08 32.4 0.0 2.9e-06 27.2 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 CRG92353.1 - 6.8e-05 23.4 0.0 0.00076 20.0 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) NACHT PF05729.12 CRG92353.1 - 8.3e-05 22.6 0.0 0.00025 21.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Ank PF00023.30 CRG92353.1 - 9e-05 22.8 0.0 0.022 15.2 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 CRG92353.1 - 0.00022 21.5 0.0 0.0064 16.8 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) AAA_22 PF13401.6 CRG92353.1 - 0.00067 19.9 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain TrkA_N PF02254.18 CRG92353.1 - 0.13 12.5 0.2 7.4 6.9 0.0 2.5 2 0 0 2 2 2 0 TrkA-N domain DUF3431 PF11913.8 CRG92354.1 - 3.7e-85 285.1 0.2 5.1e-85 284.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3431) Lipase_3 PF01764.25 CRG92354.1 - 3.2e-38 130.8 0.0 5e-38 130.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 CRG92354.1 - 4.5e-11 42.6 0.6 3.7e-09 36.5 0.2 2.6 2 0 0 2 2 2 1 Lipase 3 N-terminal region Abhydrolase_8 PF06259.12 CRG92354.1 - 0.0012 18.5 0.7 0.0027 17.3 0.2 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase Abhydrolase_6 PF12697.7 CRG92354.1 - 0.011 16.3 4.4 0.031 14.9 4.5 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG92354.1 - 0.016 14.5 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Cutinase PF01083.22 CRG92354.1 - 0.025 14.6 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Cutinase Peptidase_M16_M PF16187.5 CRG92355.1 - 1.5e-98 329.6 0.2 2.4e-98 328.9 0.2 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 CRG92355.1 - 1.6e-35 122.8 0.0 4.4e-22 79.0 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 CRG92355.1 - 4.7e-30 104.5 3.1 2.7e-19 69.6 0.6 3.6 3 1 0 3 3 3 2 Insulinase (Peptidase family M16) SSP160 PF06933.11 CRG92355.1 - 0.07 11.3 4.0 0.11 10.7 4.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Arb2 PF09757.9 CRG92356.1 - 4.2e-102 340.7 0.8 5.7e-102 340.3 0.8 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 CRG92356.1 - 2.2e-84 283.6 0.0 4e-84 282.7 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain Gp_dh_C PF02800.20 CRG92357.1 - 1e-69 233.1 0.0 1.5e-69 232.6 0.0 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 CRG92357.1 - 6.4e-39 132.4 0.0 1.2e-38 131.5 0.0 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ADH_zinc_N PF00107.26 CRG92357.1 - 0.082 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 CRG92357.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pho88 PF10032.9 CRG92358.1 - 8.4e-80 266.3 0.2 9.7e-80 266.1 0.2 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Histone PF00125.24 CRG92359.1 - 1.1e-16 61.3 0.0 1.5e-16 60.9 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 CRG92359.1 - 2.1e-12 46.5 0.0 4.2e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 CRG92359.1 - 3.4e-05 24.0 0.0 4.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone R3H PF01424.22 CRG92360.1 - 1.6e-10 40.8 0.1 3.9e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 CRG92360.1 - 2.8e-06 27.1 0.1 4.7e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUZ-C PF12901.7 CRG92360.1 - 0.0089 16.0 3.3 0.032 14.3 3.3 2.0 1 0 0 1 1 1 1 SUZ-C motif Abhydrolase_6 PF12697.7 CRG92361.1 - 0.0096 16.5 3.1 1 9.9 1.6 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family DUF5597 PF18120.1 CRG92362.1 - 3.6e-25 88.6 0.0 6e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5597) Glyco_hydro_42 PF02449.15 CRG92362.1 - 6.1e-08 32.4 0.0 1.2e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_35 PF01301.19 CRG92362.1 - 9.8e-08 32.0 0.0 6.6e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 35 Sugar_tr PF00083.24 CRG92363.1 - 1.3e-91 307.8 20.3 1.5e-91 307.5 20.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92363.1 - 2.2e-21 76.2 39.6 3e-15 56.0 11.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Fungal_trans PF04082.18 CRG92364.1 - 7.3e-11 41.6 0.0 1.1e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain P22_Cro PF14549.6 CRG92365.1 - 0.04 13.8 0.3 0.24 11.3 0.1 1.9 1 1 1 2 2 2 0 DNA-binding transcriptional regulator Cro RHH_1 PF01402.21 CRG92365.1 - 0.2 11.7 0.3 0.37 10.8 0.1 1.5 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family p450 PF00067.22 CRG92366.1 - 1e-68 232.2 0.0 1.3e-68 231.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 CRG92368.1 - 1.6e-13 50.5 23.6 7.7e-07 29.1 8.2 2.7 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG92368.1 - 4.2e-13 48.9 0.7 1.5e-12 47.1 0.7 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain FAD_binding_3 PF01494.19 CRG92369.1 - 4.9e-24 85.2 0.0 2.8e-23 82.7 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain Fungal_trans PF04082.18 CRG92369.1 - 4.2e-12 45.7 0.1 7.1e-12 44.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Pyr_redox_2 PF07992.14 CRG92369.1 - 2.1e-07 30.5 0.3 0.00029 20.2 0.1 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Abhydrolase_6 PF12697.7 CRG92369.1 - 6.7e-06 26.9 0.0 2.4e-05 25.1 0.0 2.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family NAD_binding_8 PF13450.6 CRG92369.1 - 6e-05 23.2 0.9 0.00016 21.9 0.3 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG92369.1 - 6.7e-05 22.6 0.2 0.0065 16.1 0.5 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG92369.1 - 6.9e-05 22.3 0.1 0.0092 15.3 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AXE1 PF05448.12 CRG92369.1 - 0.0001 21.1 0.1 0.00018 20.3 0.1 1.2 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) DLH PF01738.18 CRG92369.1 - 0.00048 19.7 0.0 0.091 12.3 0.0 2.3 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 CRG92369.1 - 0.00048 19.8 0.0 0.02 14.5 0.0 2.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold FAD_binding_2 PF00890.24 CRG92369.1 - 0.0031 16.7 0.9 0.0054 15.9 0.9 1.3 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 CRG92369.1 - 0.0033 16.5 0.1 0.051 12.6 0.1 2.2 1 1 0 1 1 1 1 Lycopene cyclase protein SE PF08491.10 CRG92369.1 - 0.0055 15.8 0.0 0.022 13.8 0.0 1.8 2 0 0 2 2 2 1 Squalene epoxidase HI0933_like PF03486.14 CRG92369.1 - 0.0063 15.3 0.1 0.34 9.5 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 CRG92369.1 - 0.0066 15.8 0.1 0.55 9.5 0.0 2.7 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 CRG92369.1 - 0.016 14.1 2.0 11 4.8 0.1 3.4 3 1 1 4 4 4 0 Tryptophan halogenase BAAT_C PF08840.11 CRG92369.1 - 0.021 14.7 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Thi4 PF01946.17 CRG92369.1 - 0.053 12.7 0.2 0.095 11.9 0.2 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 CRG92369.1 - 0.057 14.0 0.3 12 6.5 0.0 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG92369.1 - 0.12 12.4 0.2 0.4 10.6 0.1 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding MINDY_DUB PF04424.13 CRG92370.1 - 1.9e-18 66.6 0.0 3.5e-18 65.7 0.0 1.4 1 0 0 1 1 1 1 MINDY deubiquitinase Gcd10p PF04189.13 CRG92371.1 - 7.7e-117 389.7 0.0 1.1e-116 389.2 0.0 1.2 1 0 0 1 1 1 1 Gcd10p family CDC45 PF02724.14 CRG92371.1 - 0.0058 15.0 2.1 0.01 14.2 2.1 1.3 1 0 0 1 1 1 1 CDC45-like protein BSP_II PF05432.11 CRG92371.1 - 1.1 8.9 15.5 0.017 14.9 8.0 1.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SpoIIIAH PF12685.7 CRG92371.1 - 8.5 6.1 16.6 1.7 8.4 6.3 2.5 3 0 0 3 3 3 0 SpoIIIAH-like protein P21-Arc PF04062.14 CRG92372.1 - 3e-66 222.8 0.0 3.7e-66 222.5 0.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 CRG92372.1 - 0.022 14.8 0.1 0.043 13.9 0.1 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide Rep_fac_C PF08542.11 CRG92373.1 - 3.5e-17 62.6 0.0 9.8e-17 61.2 0.0 1.8 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 CRG92373.1 - 5.5e-16 59.2 0.0 1e-15 58.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 CRG92373.1 - 3.4e-12 46.4 0.3 8.5e-12 45.1 0.0 1.9 2 1 0 2 2 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 CRG92373.1 - 2.6e-09 37.3 0.0 6.1e-09 36.1 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_30 PF13604.6 CRG92373.1 - 5.1e-07 29.6 0.2 1.3e-06 28.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 CRG92373.1 - 1.3e-06 28.7 0.3 1.5e-05 25.3 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 CRG92373.1 - 2e-06 28.3 0.1 1.8e-05 25.2 0.1 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_11 PF13086.6 CRG92373.1 - 2.7e-06 27.4 0.2 8.5e-05 22.5 0.0 2.2 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 CRG92373.1 - 3.2e-05 23.9 0.1 0.00022 21.3 0.1 2.4 2 1 1 3 3 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 CRG92373.1 - 3.4e-05 23.7 0.0 6e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 CRG92373.1 - 4.7e-05 23.2 0.0 9.3e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit RuvB_N PF05496.12 CRG92373.1 - 6.7e-05 22.7 0.0 0.0002 21.2 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 CRG92373.1 - 8.3e-05 22.9 0.0 0.00042 20.6 0.0 2.4 1 1 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 CRG92373.1 - 9.6e-05 22.7 0.1 0.00034 21.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 CRG92373.1 - 0.00015 21.8 0.0 0.0019 18.2 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_3 PF07726.11 CRG92373.1 - 0.00021 21.1 0.1 0.001 18.9 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 CRG92373.1 - 0.00032 20.0 0.0 0.00059 19.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ResIII PF04851.15 CRG92373.1 - 0.00075 19.5 0.0 0.058 13.4 0.0 2.4 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_18 PF13238.6 CRG92373.1 - 0.0012 19.3 0.0 0.0025 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 CRG92373.1 - 0.0035 16.8 0.0 0.023 14.1 0.0 2.2 2 0 0 2 2 2 1 Bacterial TniB protein AAA_28 PF13521.6 CRG92373.1 - 0.0038 17.5 0.1 0.0073 16.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 CRG92373.1 - 0.0062 16.3 0.1 0.048 13.4 0.1 2.1 1 1 1 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 CRG92373.1 - 0.0071 15.8 0.5 0.53 9.7 0.0 2.3 1 1 1 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 CRG92373.1 - 0.0072 15.7 0.1 0.073 12.4 0.1 2.4 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 CRG92373.1 - 0.0088 15.6 0.0 0.026 14.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 CRG92373.1 - 0.013 15.2 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF2075 PF09848.9 CRG92373.1 - 0.018 14.3 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 CRG92373.1 - 0.022 14.3 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 CRG92373.1 - 0.029 14.0 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 CRG92373.1 - 0.03 14.7 0.0 0.068 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase TK PF00265.18 CRG92373.1 - 0.043 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Thymidine kinase T2SSE PF00437.20 CRG92373.1 - 0.075 12.1 0.0 0.15 11.1 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase_2 PF01637.18 CRG92373.1 - 0.084 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 CRG92373.1 - 0.095 13.2 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 ABC transporter His_Phos_2 PF00328.22 CRG92374.1 - 1.7e-05 24.3 0.1 0.0032 16.9 0.0 3.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) MBG PF17883.1 CRG92374.1 - 0.16 12.6 1.5 1.5 9.5 0.2 2.7 2 0 0 2 2 2 0 MBG domain Glyco_hydro_28 PF00295.17 CRG92375.1 - 1.6e-124 415.2 19.1 1.9e-124 414.9 19.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 DUF2180 PF09947.9 CRG92375.1 - 0.19 11.7 0.2 0.37 10.8 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) FMO-like PF00743.19 CRG92376.1 - 1.1e-16 60.5 0.1 1.6e-14 53.3 0.0 2.5 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 CRG92376.1 - 2.1e-10 40.3 0.0 3e-07 30.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG92376.1 - 1.3e-07 31.7 0.0 3.4e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CRG92376.1 - 2.9e-07 30.0 0.0 9.1e-06 25.0 0.0 2.6 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 CRG92376.1 - 6.8e-05 22.3 0.0 0.00081 18.7 0.0 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG92376.1 - 0.006 15.8 0.2 0.018 14.3 0.0 1.8 2 0 0 2 2 2 1 Thi4 family Ag332 PF04671.12 CRG92376.1 - 0.061 13.3 1.8 0.12 12.3 1.8 1.5 1 0 0 1 1 1 0 Erythrocyte membrane-associated giant protein antigen 332 RE_AccI PF09545.10 CRG92376.1 - 0.14 11.1 0.0 0.21 10.5 0.0 1.2 1 0 0 1 1 1 0 AccI restriction endonuclease TRI12 PF06609.13 CRG92377.1 - 3.5e-217 722.5 18.8 4.7e-217 722.1 18.8 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1 PF07690.16 CRG92377.1 - 7.8e-20 71.1 45.8 7.8e-20 71.1 45.8 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92377.1 - 1.9e-10 40.2 7.4 1.9e-10 40.2 7.4 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter E3_UFM1_ligase PF09743.9 CRG92377.1 - 0.21 11.2 0.0 0.33 10.5 0.0 1.2 1 0 0 1 1 1 0 E3 UFM1-protein ligase 1 adh_short_C2 PF13561.6 CRG92378.1 - 1.7e-49 168.5 0.2 4.3e-49 167.2 0.2 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG92378.1 - 1.4e-39 135.6 0.3 1.8e-39 135.2 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG92378.1 - 4.9e-07 29.8 0.0 8.7e-07 29.0 0.0 1.3 1 1 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 CRG92378.1 - 0.0065 15.8 0.0 0.015 14.6 0.0 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ADH_zinc_N PF00107.26 CRG92380.1 - 6e-08 32.7 0.6 1e-07 31.9 0.6 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG92380.1 - 4.9e-06 26.4 0.0 8.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PDZ_6 PF17820.1 CRG92380.1 - 0.1 12.5 0.2 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 PDZ domain AA_permease PF00324.21 CRG92381.1 - 5.8e-128 427.5 32.9 6.6e-128 427.3 32.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 CRG92381.1 - 7.8e-39 133.7 34.9 9.5e-39 133.4 34.9 1.1 1 0 0 1 1 1 1 Amino acid permease Pro_isomerase PF00160.21 CRG92383.1 - 2.7e-38 131.7 0.0 6e-38 130.6 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CHAT PF12770.7 CRG92384.1 - 1.2e-36 126.6 0.0 1.9e-36 126.0 0.0 1.3 1 0 0 1 1 1 1 CHAT domain Peptidase_C50 PF03568.17 CRG92384.1 - 0.01 15.0 0.1 0.025 13.7 0.1 1.7 1 0 0 1 1 1 0 Peptidase family C50 PvlArgDC PF01862.16 CRG92384.1 - 0.16 11.8 0.1 0.37 10.6 0.1 1.6 1 0 0 1 1 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) MFS_1 PF07690.16 CRG92385.1 - 2e-36 125.7 28.5 2e-36 125.7 28.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92385.1 - 3.7e-13 49.2 5.2 3.7e-13 49.2 5.2 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter UCH PF00443.29 CRG92386.1 - 7.6e-15 55.1 0.0 1.9e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MORN PF02493.20 CRG92386.1 - 1.2e-14 53.2 31.0 5.3e-06 26.0 0.9 4.7 4 0 0 4 4 4 4 MORN repeat Myb_DNA-binding PF00249.31 CRG92386.1 - 5.6e-11 42.5 0.0 3.3e-07 30.4 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain zf-C3HC4_3 PF13920.6 CRG92386.1 - 3.7e-05 23.5 5.3 6.3e-05 22.8 5.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MATH PF00917.26 CRG92386.1 - 0.0067 16.6 0.0 0.35 11.0 0.0 2.5 2 0 0 2 2 2 1 MATH domain USP7_ICP0_bdg PF12436.8 CRG92386.1 - 0.012 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 Myb_DNA-bind_7 PF15963.5 CRG92386.1 - 0.55 10.2 0.0 0.55 10.2 0.0 2.4 3 0 0 3 3 3 0 Myb DNA-binding like zf-RING_2 PF13639.6 CRG92386.1 - 2.3 8.6 4.2 4.4 7.7 4.2 1.4 1 0 0 1 1 1 0 Ring finger domain DS PF01916.17 CRG92387.1 - 1.6e-129 431.3 0.0 1.8e-129 431.1 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase adh_short PF00106.25 CRG92388.1 - 1.1e-16 60.9 0.0 1.5e-12 47.4 0.2 3.0 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92388.1 - 8e-06 25.6 0.0 0.00037 20.1 0.1 2.6 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92388.1 - 3.5e-05 23.8 0.0 6.3e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF4436 PF14494.6 CRG92388.1 - 0.16 11.2 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4436) Acyl-CoA_dh_1 PF00441.24 CRG92390.1 - 2.9e-29 102.2 0.3 2.9e-29 102.2 0.3 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 CRG92390.1 - 8e-21 74.0 0.1 1.9e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 CRG92390.1 - 1.5e-19 70.0 0.2 3.1e-19 68.9 0.2 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CRG92390.1 - 1.7e-07 31.9 0.2 6.5e-07 30.0 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 CRG92390.1 - 0.00037 20.8 0.0 0.00095 19.4 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Methyltr_RsmB-F PF01189.17 CRG92391.1 - 4.3e-73 245.2 0.0 7e-73 244.6 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 CRG92391.1 - 8.5e-08 32.6 0.0 2.3e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF PCMT PF01135.19 CRG92391.1 - 0.014 15.2 0.0 0.027 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 CRG92391.1 - 0.05 13.7 0.0 0.097 12.8 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 CRG92391.1 - 0.059 13.2 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DUF2431 PF10354.9 CRG92391.1 - 0.085 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) ANTAR PF03861.14 CRG92391.1 - 0.12 12.2 0.5 0.38 10.6 0.5 1.8 1 0 0 1 1 1 0 ANTAR domain Apidaecin PF00807.17 CRG92391.1 - 7.4 6.8 6.2 1.6 8.9 0.8 2.7 2 0 0 2 2 2 0 Apidaecin Blt1 PF12754.7 CRG92392.1 - 1.8e-59 200.4 0.1 2.2e-59 200.1 0.1 1.1 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 CRG92392.1 - 1.1e-21 76.2 0.0 1.9e-21 75.4 0.0 1.4 1 0 0 1 1 1 1 Get5 carboxyl domain XPA_C PF05181.12 CRG92393.1 - 8.3e-26 89.7 2.7 1.8e-25 88.6 2.7 1.6 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 CRG92393.1 - 0.19 11.8 8.8 0.34 11.0 8.8 1.4 1 0 0 1 1 1 0 XPA protein N-terminal zf-AD PF07776.15 CRG92393.1 - 0.58 10.4 4.3 0.42 10.9 1.5 2.3 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) PIG-P PF08510.12 CRG92394.1 - 5.4e-18 65.1 0.2 2.8e-13 49.8 0.0 2.6 1 1 1 2 2 2 2 PIG-P SDA1 PF05285.12 CRG92394.1 - 0.0053 16.2 2.4 0.0069 15.9 2.4 1.2 1 0 0 1 1 1 1 SDA1 DUF2457 PF10446.9 CRG92394.1 - 0.84 8.7 20.2 2.1 7.4 20.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 CRG92394.1 - 0.86 7.7 11.2 1.1 7.3 11.2 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 CRG92394.1 - 3 7.1 15.5 5.3 6.3 15.5 1.4 1 0 0 1 1 1 0 NOA36 protein Sigma70_ner PF04546.13 CRG92394.1 - 7.6 6.4 12.2 13 5.6 12.2 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region S-antigen PF05756.11 CRG92394.1 - 7.6 7.0 11.8 23 5.4 11.8 1.8 1 0 0 1 1 1 0 S-antigen protein Striatin PF08232.12 CRG92395.1 - 4.8e-46 157.2 1.5 4.8e-46 157.2 1.5 3.1 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 CRG92395.1 - 7.8e-24 83.5 25.3 0.00012 22.8 0.0 8.6 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG92395.1 - 0.00038 20.7 0.1 0.43 10.9 0.0 4.2 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain ADH_N_2 PF16884.5 CRG92395.1 - 0.042 13.7 0.0 0.14 12.1 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase eIF2A PF08662.11 CRG92395.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 CRG92395.1 - 0.18 10.8 0.0 0.37 9.7 0.0 1.5 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF2570 PF10828.8 CRG92395.1 - 2.9 7.7 9.7 9.2 6.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) RSN1_7TM PF02714.15 CRG92396.1 - 1.4e-88 296.8 22.3 3.7e-88 295.4 20.4 2.4 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CRG92396.1 - 9.9e-46 155.3 2.5 9.9e-46 155.3 2.5 2.6 2 1 1 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CRG92396.1 - 3.1e-32 112.2 0.6 4.8e-32 111.6 0.6 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 CRG92396.1 - 1.2e-28 99.2 1.7 2.1e-28 98.3 0.4 2.1 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter FlaF PF07309.11 CRG92396.1 - 0.005 16.8 0.3 0.017 15.1 0.0 1.9 2 0 0 2 2 2 1 Flagellar protein FlaF DYW_deaminase PF14432.6 CRG92396.1 - 0.11 12.4 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases Arginase PF00491.21 CRG92397.1 - 1.7e-91 306.6 0.0 2e-91 306.4 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 CRG92397.1 - 0.033 14.4 0.0 0.052 13.8 0.0 1.3 1 0 0 1 1 1 0 UPF0489 domain MatE PF01554.18 CRG92398.1 - 5.5e-54 182.2 22.7 5.6e-29 100.9 4.7 2.4 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 CRG92398.1 - 0.0013 18.8 19.0 0.0013 18.8 19.0 3.9 2 1 1 3 3 3 2 Polysaccharide biosynthesis C-terminal domain CD225 PF04505.12 CRG92398.1 - 1.5 9.0 9.2 0.06 13.5 1.2 2.9 3 0 0 3 3 3 0 Interferon-induced transmembrane protein MFS_1 PF07690.16 CRG92399.1 - 6.3e-41 140.5 35.8 8.2e-35 120.4 28.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92399.1 - 1.9e-16 60.0 0.1 1.9e-16 60.0 0.1 2.5 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 CRG92399.1 - 0.0011 17.5 2.2 0.0011 17.5 2.2 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ADH_zinc_N PF00107.26 CRG92400.1 - 2.8e-11 43.5 0.0 6.2e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG92400.1 - 5.8e-05 24.2 0.0 0.00011 23.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG92400.1 - 6.8e-05 22.7 0.1 0.0012 18.7 0.1 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Cerato-platanin PF07249.12 CRG92401.1 - 5.1e-42 142.7 0.8 6.1e-42 142.5 0.8 1.1 1 0 0 1 1 1 1 Cerato-platanin adh_short PF00106.25 CRG92402.1 - 1e-26 93.6 0.2 2.1e-26 92.6 0.2 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92402.1 - 2.9e-19 69.6 0.1 5.8e-19 68.6 0.1 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92402.1 - 1.9e-08 34.4 0.0 3e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG92402.1 - 0.012 15.1 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG92402.1 - 0.027 13.9 0.1 0.035 13.5 0.1 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 CRG92402.1 - 0.13 12.5 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain WW PF00397.26 CRG92403.1 - 2.9e-05 24.1 1.0 2.9e-05 24.1 1.0 2.0 2 0 0 2 2 2 1 WW domain PAP_PilO PF06864.12 CRG92403.1 - 0.82 8.4 3.6 0.67 8.7 1.1 2.0 2 1 1 3 3 3 0 Pilin accessory protein (PilO) DUF3425 PF11905.8 CRG92404.1 - 6.3e-17 61.7 0.2 1.6e-16 60.4 0.2 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) DUF390 PF04094.14 CRG92404.1 - 0.055 11.8 0.2 0.072 11.4 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Abhydrolase_6 PF12697.7 CRG92405.1 - 1.2e-14 55.5 0.0 1.4e-14 55.2 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG92405.1 - 3.3e-05 23.3 0.3 0.00072 18.9 0.1 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 CRG92405.1 - 0.00063 19.5 0.1 0.004 16.9 0.0 2.0 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_5 PF12695.7 CRG92405.1 - 0.0016 18.2 1.2 0.0065 16.3 0.2 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 CRG92405.1 - 0.0026 17.9 0.1 0.0042 17.2 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 CRG92405.1 - 0.012 15.3 0.1 0.23 11.1 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 CRG92405.1 - 0.048 13.3 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase LIDHydrolase PF10230.9 CRG92405.1 - 0.075 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase OPT PF03169.15 CRG92406.1 - 1.1e-132 443.8 44.9 1.3e-132 443.6 44.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein ThrE PF06738.12 CRG92406.1 - 0.078 12.3 4.1 0.24 10.8 0.1 2.7 2 0 0 2 2 2 0 Putative threonine/serine exporter Acyl-CoA_dh_2 PF08028.11 CRG92407.1 - 6e-12 46.0 0.2 1.1e-11 45.2 0.2 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 CRG92407.1 - 2.2e-06 27.7 0.1 5.2e-06 26.6 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 CRG92407.1 - 7.6e-06 26.6 0.0 2.3e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 CRG92407.1 - 0.0074 16.5 0.3 0.031 14.5 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 CRG92407.1 - 0.03 14.0 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal FAD_binding_3 PF01494.19 CRG92408.1 - 7.4e-78 262.2 0.0 1e-77 261.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 CRG92408.1 - 6.1e-18 65.4 0.2 7.1e-14 52.2 0.1 2.5 1 1 1 2 2 2 2 Phenol hydroxylase, C-terminal dimerisation domain SE PF08491.10 CRG92408.1 - 0.0071 15.4 0.0 0.34 9.9 0.0 2.2 2 0 0 2 2 2 1 Squalene epoxidase Thi4 PF01946.17 CRG92408.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Thi4 family MCRA PF06100.11 CRG92408.1 - 0.048 12.5 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 MCRA family DAO PF01266.24 CRG92408.1 - 0.077 12.6 0.1 3.4 7.1 0.0 2.2 1 1 1 2 2 2 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG92408.1 - 0.091 13.0 0.2 0.57 10.4 0.0 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DUF424 PF04242.13 CRG92409.1 - 0.15 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF424) AA_permease_2 PF13520.6 CRG92410.1 - 2.5e-69 234.1 50.6 3.1e-69 233.8 50.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 CRG92410.1 - 1.8e-22 79.6 40.2 2.5e-22 79.1 40.2 1.1 1 0 0 1 1 1 1 Amino acid permease RGS PF00615.19 CRG92411.1 - 1.1e-32 112.7 0.2 3.1e-32 111.3 0.1 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 CRG92411.1 - 6.3e-15 55.0 0.0 2.9e-14 52.9 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PBP PF01161.20 CRG92412.1 - 5.6e-09 36.4 0.2 7.3e-09 36.0 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Aminotran_5 PF00266.19 CRG92414.1 - 1.4e-33 116.4 0.0 1.8e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 CRG92414.1 - 1.9e-05 24.0 0.0 0.0032 16.7 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 CRG92414.1 - 0.0055 15.3 0.0 0.01 14.4 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme PTR2 PF00854.21 CRG92415.1 - 6.1e-66 222.9 1.1 9.9e-66 222.2 1.1 1.2 1 0 0 1 1 1 1 POT family 2OG-FeII_Oxy PF03171.20 CRG92415.1 - 1e-12 48.4 0.0 2.1e-12 47.4 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 CRG92415.1 - 1.4e-10 41.9 0.0 2.9e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Cys_Met_Meta_PP PF01053.20 CRG92416.1 - 4.7e-144 479.6 0.0 5.8e-144 479.3 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GST_N_2 PF13409.6 CRG92416.1 - 4.4e-20 71.7 0.0 1.6e-19 70.0 0.0 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG92416.1 - 4.6e-09 36.2 0.0 1.8e-08 34.2 0.0 2.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Aminotran_5 PF00266.19 CRG92416.1 - 5.3e-08 32.2 0.2 9.4e-08 31.4 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 CRG92416.1 - 5.3e-05 22.7 0.0 0.0001 21.7 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GST_C_3 PF14497.6 CRG92416.1 - 0.0089 16.2 0.0 0.047 13.9 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG92416.1 - 0.023 15.1 0.0 5 7.6 0.0 2.9 3 0 0 3 3 3 0 Glutathione S-transferase, N-terminal domain Aldo_ket_red PF00248.21 CRG92417.1 - 1e-72 244.8 0.0 1.2e-72 244.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Sugar_tr PF00083.24 CRG92418.1 - 1.1e-93 314.5 28.4 1.3e-93 314.3 28.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92418.1 - 2e-25 89.5 40.3 1.7e-23 83.1 29.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_2 PF04550.12 CRG92418.1 - 0.5 11.0 7.5 0.6 10.7 4.2 2.7 2 0 0 2 2 2 0 Phage holin family 2 OATP PF03137.20 CRG92418.1 - 0.92 7.7 14.5 1.7 6.8 2.5 3.3 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2530 PF10745.9 CRG92418.1 - 5.6 7.3 16.1 0.23 11.7 3.8 3.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2530) Zn_clus PF00172.18 CRG92419.1 - 2.7e-08 33.8 9.9 4.2e-08 33.2 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Porphyrn_cat_1 PF18206.1 CRG92419.1 - 0.071 13.7 0.1 0.071 13.7 0.1 1.8 2 0 0 2 2 2 0 Porphyranase catalytic subdomain 1 Fungal_trans_2 PF11951.8 CRG92419.1 - 0.15 10.9 0.0 0.21 10.3 0.0 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF4907 PF16250.5 CRG92419.1 - 0.82 9.6 4.9 1.4 8.8 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4907) Acetyltransf_10 PF13673.7 CRG92420.1 - 0.00079 19.4 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 CRG92420.1 - 0.012 15.9 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 CRG92420.1 - 0.066 13.3 0.1 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain SRR1 PF07985.12 CRG92421.1 - 2.1e-10 40.5 0.0 3.5e-10 39.8 0.0 1.4 1 0 0 1 1 1 1 SRR1 HORMA PF02301.18 CRG92421.1 - 0.065 12.8 0.0 0.094 12.3 0.0 1.2 1 0 0 1 1 1 0 HORMA domain FMO-like PF00743.19 CRG92422.1 - 3e-33 115.0 0.0 2e-17 62.9 0.0 3.3 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 CRG92422.1 - 1.8e-11 43.9 0.2 2.1e-07 30.5 0.0 3.2 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG92422.1 - 3.3e-07 30.4 0.1 3.8e-06 27.0 0.0 2.9 3 1 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 CRG92422.1 - 3e-06 27.4 0.0 7.8e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG92422.1 - 3.9e-06 26.3 0.1 0.00018 20.9 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG92422.1 - 1.8e-05 24.0 1.3 0.032 13.4 0.1 3.6 3 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG92422.1 - 0.00019 21.1 0.4 0.034 13.7 0.3 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase Semialdhyde_dh PF01118.24 CRG92422.1 - 0.00085 19.8 0.0 0.46 10.9 0.0 3.3 4 0 0 4 4 3 1 Semialdehyde dehydrogenase, NAD binding domain Thi4 PF01946.17 CRG92422.1 - 0.0011 18.3 0.0 0.0091 15.3 0.0 2.1 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 CRG92422.1 - 0.075 11.7 0.6 0.15 10.8 0.4 1.5 2 0 0 2 2 2 0 HI0933-like protein FAD_binding_2 PF00890.24 CRG92422.1 - 0.13 11.3 0.1 0.17 10.9 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 CRG92422.1 - 0.17 11.9 0.1 6.2 6.9 0.0 3.2 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 CRG92422.1 - 0.21 12.2 0.0 0.64 10.6 0.0 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 CRG92423.1 - 2.3e-19 69.9 0.1 1e-13 51.3 0.0 2.3 1 1 1 2 2 2 2 GMC oxidoreductase Trp_halogenase PF04820.14 CRG92423.1 - 0.00023 20.1 0.0 0.00032 19.7 0.0 1.1 1 0 0 1 1 1 1 Tryptophan halogenase Lycopene_cycl PF05834.12 CRG92423.1 - 0.00026 20.2 0.2 0.00035 19.7 0.2 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 CRG92423.1 - 0.039 13.2 0.0 0.055 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase p450 PF00067.22 CRG92424.1 - 2.6e-27 95.7 0.0 4.4e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Cytochrome P450 Herpes_gE PF02480.16 CRG92424.1 - 0.0084 14.9 0.0 0.013 14.3 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E TMEM154 PF15102.6 CRG92424.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family Recep_L_domain PF01030.24 CRG92424.1 - 0.016 15.3 0.6 0.27 11.4 0.3 2.9 2 1 0 2 2 2 0 Receptor L domain Plasmodium_Vir PF05795.11 CRG92424.1 - 0.036 13.5 0.1 0.06 12.8 0.1 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Amnionless PF14828.6 CRG92424.1 - 0.06 12.2 0.0 0.095 11.5 0.0 1.2 1 0 0 1 1 1 0 Amnionless stn_TNFRSF12A PF12191.8 CRG92424.1 - 0.089 13.0 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain Alpha_GJ PF03229.13 CRG92424.1 - 0.099 13.2 4.1 0.19 12.3 4.1 1.4 1 0 0 1 1 1 0 Alphavirus glycoprotein J DUF2561 PF10812.8 CRG92424.1 - 0.11 12.5 0.2 0.25 11.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) TraL PF07178.11 CRG92424.1 - 0.17 12.4 0.1 0.35 11.4 0.1 1.5 1 0 0 1 1 1 0 TraL protein Med3 PF11593.8 CRG92424.1 - 0.25 10.5 4.4 0.52 9.4 4.4 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ifi-6-16 PF06140.13 CRG92425.1 - 2.2e-08 33.9 28.0 2.2e-08 33.9 28.0 2.3 1 1 1 2 2 2 1 Interferon-induced 6-16 family Sugar_tr PF00083.24 CRG92426.1 - 3.5e-112 375.6 27.0 4e-112 375.4 27.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92426.1 - 3.2e-19 69.1 23.2 3.2e-19 69.1 23.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 CRG92426.1 - 1.2e-06 27.3 25.7 5.1e-05 22.0 6.7 3.0 3 1 1 4 4 4 2 MFS/sugar transport protein Pox_A14 PF05767.12 CRG92426.1 - 0.18 11.9 4.2 1.2 9.3 3.8 2.5 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Fe-ADH PF00465.19 CRG92427.1 - 1.7e-28 99.5 0.0 2.3e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase GST_N PF02798.20 CRG92428.1 - 2.3e-11 43.9 0.0 4e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 CRG92428.1 - 2.5e-10 40.2 0.1 1.6e-07 31.2 0.1 2.2 2 0 0 2 2 2 2 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 CRG92428.1 - 1.8e-09 37.9 0.0 2.9e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 CRG92428.1 - 7.5e-09 35.7 0.1 7.3e-07 29.3 0.0 2.2 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 CRG92428.1 - 4.4e-07 30.1 0.0 8.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 CRG92428.1 - 1.6e-06 28.2 0.1 0.00023 21.3 0.0 2.1 1 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 CRG92428.1 - 0.023 14.5 0.6 0.1 12.4 0.1 2.2 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain MFS_1 PF07690.16 CRG92429.1 - 1e-28 100.3 23.4 1e-28 100.3 23.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 CRG92429.1 - 0.0084 14.6 1.2 0.012 14.0 1.2 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Ctr PF04145.15 CRG92429.1 - 0.17 12.5 3.3 7.4 7.2 0.1 3.3 2 1 1 3 3 3 0 Ctr copper transporter family MFS_1 PF07690.16 CRG92430.1 - 9.3e-40 136.6 35.0 9.3e-40 136.6 35.0 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily Esterase_phd PF10503.9 CRG92431.1 - 0.0029 17.1 0.1 0.0078 15.7 0.1 1.6 1 1 0 1 1 1 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 CRG92431.1 - 0.074 12.5 0.4 0.17 11.4 0.3 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Esterase PF00756.20 CRG92431.1 - 0.075 12.7 0.0 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 Putative esterase TauD PF02668.16 CRG92432.1 - 1.5e-40 139.7 1.3 2.2e-40 139.2 1.3 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Fungal_trans PF04082.18 CRG92432.1 - 1.3e-14 53.9 1.1 2.3e-14 53.1 1.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92432.1 - 0.005 16.9 9.8 0.012 15.8 9.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gpr1_Fun34_YaaH PF01184.19 CRG92433.1 - 2.8e-69 232.9 18.2 3.2e-69 232.7 18.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Sec61_beta PF03911.16 CRG92433.1 - 0.31 11.1 0.0 0.31 11.1 0.0 2.7 4 0 0 4 4 4 0 Sec61beta family DUF2070 PF09843.9 CRG92433.1 - 1.2 7.3 15.2 1.5 7.0 15.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FAA_hydrolase PF01557.18 CRG92434.1 - 6.2e-64 215.6 0.0 9.8e-64 215.0 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Abhydrolase_1 PF00561.20 CRG92434.1 - 9.3e-26 91.0 0.1 1.6e-19 70.6 0.2 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG92434.1 - 3.8e-19 70.2 0.5 6.4e-19 69.4 0.5 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG92434.1 - 7.3e-16 58.2 0.0 1.8e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 CRG92434.1 - 7.4e-06 25.9 0.3 2e-05 24.6 0.3 1.8 1 1 0 1 1 1 1 Serine hydrolase PGAP1 PF07819.13 CRG92434.1 - 0.00029 20.6 0.1 0.14 11.8 0.1 2.3 2 0 0 2 2 2 2 PGAP1-like protein Ndr PF03096.14 CRG92434.1 - 0.00089 18.0 0.0 0.0012 17.6 0.0 1.2 1 0 0 1 1 1 1 Ndr family Palm_thioest PF02089.15 CRG92434.1 - 0.029 14.2 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_5 PF12695.7 CRG92434.1 - 0.036 13.9 0.0 6.9 6.4 0.0 2.8 2 1 1 3 3 3 0 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 CRG92434.1 - 0.046 13.8 0.0 0.56 10.4 0.0 2.3 2 0 0 2 2 2 0 TAP-like protein Phytoreo_S7 PF07236.11 CRG92434.1 - 0.13 10.6 0.1 0.19 10.0 0.1 1.2 1 0 0 1 1 1 0 Phytoreovirus S7 protein RNase_H PF00075.24 CRG92435.1 - 1e-06 29.0 0.6 2.2e-06 27.9 0.1 1.8 2 0 0 2 2 2 1 RNase H Dioxygenase_C PF00775.21 CRG92436.1 - 7.7e-11 41.8 0.0 1.4e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Dioxygenase Metallophos PF00149.28 CRG92438.1 - 1.8e-12 48.2 0.1 1.6e-11 45.1 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG92438.1 - 1.1e-05 25.6 0.0 0.0018 18.5 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain HD PF01966.22 CRG92439.1 - 0.026 14.8 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 HD domain SATase_N PF06426.14 CRG92440.1 - 0.047 14.1 0.0 0.068 13.6 0.0 1.2 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal Pox_P4A PF03395.14 CRG92440.1 - 0.16 9.6 0.0 0.17 9.5 0.0 1.0 1 0 0 1 1 1 0 Poxvirus P4A protein Glyco_hydro_15 PF00723.21 CRG92441.1 - 9.1e-107 357.6 0.0 1.1e-106 357.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Sugar_tr PF00083.24 CRG92442.1 - 1.2e-76 258.5 17.0 1.5e-76 258.2 17.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 CRG92442.1 - 4.7e-17 62.0 31.7 6.2e-13 48.4 15.4 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92443.1 - 8.2e-05 21.6 1.2 9.4e-05 21.4 1.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Abhydrolase_6 PF12697.7 CRG92445.1 - 1.1e-07 32.6 0.4 4e-07 30.9 0.4 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family CDH-cyt PF16010.5 CRG92446.1 - 3.7e-63 212.5 3.1 5.2e-63 212.0 3.1 1.2 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase DOMON PF03351.17 CRG92446.1 - 0.0013 18.9 0.7 0.0031 17.7 0.1 1.9 2 0 0 2 2 2 1 DOMON domain LPMO_10 PF03067.15 CRG92447.1 - 6.7e-10 39.9 13.6 1.2e-09 39.1 13.6 1.5 1 1 0 1 1 1 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Glyco_hydro_61 PF03443.14 CRG92447.1 - 0.00093 19.2 1.2 0.088 12.7 0.2 2.1 2 0 0 2 2 2 2 Glycosyl hydrolase family 61 VirDNA-topo-I_N PF09266.10 CRG92447.1 - 0.057 13.6 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Viral DNA topoisomerase I, N-terminal MFS_1 PF07690.16 CRG92448.1 - 1.3e-21 77.0 54.6 1.3e-21 77.0 54.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily NAD_binding_9 PF13454.6 CRG92449.1 - 7.7e-25 87.7 0.0 1.5e-24 86.8 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG92449.1 - 8e-12 45.0 0.0 7.5e-09 35.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 CRG92449.1 - 5e-05 22.7 0.0 0.0062 15.8 0.0 3.2 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 CRG92449.1 - 0.00036 19.8 0.0 0.22 10.6 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 CRG92449.1 - 0.00057 19.6 0.3 0.0078 15.8 0.1 2.5 3 0 0 3 3 3 1 FAD dependent oxidoreductase CxC3 PF18804.1 CRG92449.1 - 0.041 13.7 0.4 0.096 12.5 0.4 1.5 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases NAD_binding_8 PF13450.6 CRG92449.1 - 0.11 12.8 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG92449.1 - 0.12 11.4 0.0 1.1 8.3 0.0 2.3 3 0 0 3 3 3 0 FAD binding domain Condensation PF00668.20 CRG92450.1 - 1.5e-68 231.5 0.1 4.1e-33 114.7 0.0 2.7 3 0 0 3 3 3 2 Condensation domain AMP-binding PF00501.28 CRG92450.1 - 4.5e-68 229.8 0.0 8.1e-68 228.9 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 CRG92450.1 - 4.5e-23 81.4 0.4 6.4e-11 42.4 0.0 3.8 4 0 0 4 4 4 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 CRG92450.1 - 0.0036 18.2 0.0 0.016 16.2 0.0 2.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Zn_clus PF00172.18 CRG92451.1 - 1.9e-06 27.9 6.0 5.2e-06 26.5 6.0 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG92451.1 - 0.0024 17.0 0.0 0.0043 16.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fungal_trans PF04082.18 CRG92453.1 - 1.5e-15 57.0 1.7 3.1e-15 55.9 1.7 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92453.1 - 2.4e-08 34.0 8.2 2.4e-08 34.0 8.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 CRG92453.1 - 1.1e-06 28.7 10.0 0.00093 19.5 1.3 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 CRG92453.1 - 0.0012 19.1 3.4 0.0012 19.1 3.4 4.5 4 1 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 CRG92453.1 - 0.031 15.1 0.9 0.031 15.1 0.9 3.4 4 0 0 4 4 4 0 C2H2-type zinc finger p450 PF00067.22 CRG92454.1 - 4.2e-78 263.1 0.0 5.3e-78 262.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 CRG92455.1 - 2.1e-25 89.4 57.9 5.1e-25 88.1 50.5 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily AMP-binding PF00501.28 CRG92456.1 - 3.3e-65 220.3 0.0 5.2e-65 219.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 CRG92456.1 - 1.4e-50 172.3 0.0 1.7e-28 99.5 0.0 3.2 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.25 CRG92456.1 - 2.5e-21 75.8 4.1 1.1e-11 44.9 0.1 3.5 3 0 0 3 3 3 2 Phosphopantetheine attachment site Cupin_2 PF07883.11 CRG92457.1 - 2e-05 24.2 0.0 4.6e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Cupin domain p450 PF00067.22 CRG92458.1 - 5.2e-80 269.5 0.0 6.8e-80 269.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 adh_short PF00106.25 CRG92459.1 - 2.2e-15 56.6 0.5 2.7e-15 56.3 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 CRG92459.1 - 2.7e-06 27.4 0.3 4.1e-06 26.8 0.3 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 CRG92459.1 - 4.9e-05 23.0 0.3 6e-05 22.7 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short_C2 PF13561.6 CRG92460.1 - 1.6e-84 283.1 1.7 2.6e-56 190.8 1.3 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 CRG92460.1 - 1.4e-74 249.8 7.7 5.5e-38 130.4 3.9 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 CRG92460.1 - 2.3e-13 50.5 1.4 4.5e-08 33.2 0.2 2.6 2 1 0 2 2 2 2 KR domain Epimerase PF01370.21 CRG92460.1 - 2.1e-05 24.1 2.9 0.0062 16.0 0.3 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family MacB_PCD PF12704.7 CRG92460.1 - 0.021 15.2 2.8 0.089 13.1 2.0 2.2 2 0 0 2 2 2 0 MacB-like periplasmic core domain 3HCDH_N PF02737.18 CRG92460.1 - 0.066 13.1 0.2 14 5.6 0.1 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ketoacyl-synt PF00109.26 CRG92461.1 - 4.6e-63 213.1 0.1 1.3e-62 211.7 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 CRG92461.1 - 3.5e-52 177.9 2.4 5.1e-52 177.4 1.2 1.8 2 0 0 2 2 2 1 Acyl transferase domain PS-DH PF14765.6 CRG92461.1 - 1.5e-51 175.4 1.1 2.1e-51 175.0 0.4 1.6 2 0 0 2 2 2 1 Polyketide synthase dehydratase KR PF08659.10 CRG92461.1 - 1.8e-51 174.6 0.2 4e-51 173.5 0.2 1.7 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 CRG92461.1 - 4.6e-35 120.2 0.5 4.6e-35 120.2 0.5 2.8 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG92461.1 - 4.4e-20 72.2 0.0 1.1e-19 70.9 0.0 1.8 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CRG92461.1 - 3.7e-11 43.1 0.0 5.1e-10 39.4 0.0 2.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG92461.1 - 5.5e-09 35.8 0.1 1.1e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 short chain dehydrogenase ADH_N PF08240.12 CRG92461.1 - 7.9e-08 32.2 0.1 2.2e-07 30.7 0.1 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 CRG92461.1 - 2.9e-07 31.6 0.0 1.4e-06 29.4 0.0 2.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CRG92461.1 - 4.6e-06 26.4 0.4 1.3e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 CRG92461.1 - 7.6e-05 23.0 0.1 0.00024 21.4 0.1 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 CRG92461.1 - 0.0092 16.7 0.0 0.032 15.0 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ACP_syn_III PF08545.10 CRG92461.1 - 0.091 12.6 0.3 0.3 11.0 0.3 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF5356 PF17309.2 CRG92462.1 - 0.61 10.1 4.1 12 5.9 0.2 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5356) AAA PF00004.29 CRG92464.1 - 1.8e-17 64.0 0.1 6e-17 62.3 0.0 2.0 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 CRG92464.1 - 2.1e-06 28.0 1.7 0.014 15.6 0.0 3.7 2 1 1 3 3 3 2 AAA domain AAA_5 PF07728.14 CRG92464.1 - 0.00018 21.6 0.2 0.00071 19.6 0.0 2.2 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG92464.1 - 0.00041 20.8 0.2 0.00041 20.8 0.2 2.9 3 2 1 4 4 3 1 AAA ATPase domain AAA_33 PF13671.6 CRG92464.1 - 0.00089 19.4 0.0 0.0026 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG92464.1 - 0.0044 16.7 0.0 0.009 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 CRG92464.1 - 0.0046 16.4 0.0 0.011 15.2 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 CRG92464.1 - 0.0089 15.3 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 CRG92464.1 - 0.012 15.3 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 CRG92464.1 - 0.017 15.0 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 CRG92464.1 - 0.017 14.8 0.0 0.052 13.3 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 CRG92464.1 - 0.024 14.0 0.3 0.13 11.6 0.1 2.3 2 0 0 2 2 2 0 KaiC AAA_19 PF13245.6 CRG92464.1 - 0.058 13.7 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 CRG92464.1 - 0.06 12.6 0.1 3.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 CRG92464.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 CRG92464.1 - 0.072 13.6 0.0 0.36 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 CRG92464.1 - 0.092 12.7 0.1 0.6 10.0 0.0 2.4 2 1 1 3 3 2 0 NACHT domain AAA_28 PF13521.6 CRG92464.1 - 0.1 12.9 1.0 1.6 9.0 0.1 2.5 1 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 CRG92464.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 CRG92464.1 - 0.12 12.7 0.0 0.42 11.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_24 PF13479.6 CRG92464.1 - 0.16 11.7 0.0 0.61 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Myb_DNA-bind_6 PF13921.6 CRG92465.1 - 0.00027 21.1 0.9 0.00055 20.1 0.9 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CRG92465.1 - 0.0098 16.1 0.1 0.022 14.9 0.1 1.5 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Sporozoite_P67 PF05642.11 CRG92465.1 - 0.024 12.8 9.5 0.041 12.0 9.5 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Myb_DNA-binding PF00249.31 CRG92465.1 - 0.032 14.4 1.4 0.084 13.1 1.4 1.8 1 0 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 CRG92467.1 - 8.8e-27 93.0 0.9 5.9e-16 58.4 0.1 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 CRG92467.1 - 1.6e-17 63.5 3.2 1.6e-13 50.7 0.1 2.6 1 1 1 2 2 2 2 Myb-like DNA-binding domain DUF2774 PF11242.8 CRG92467.1 - 0.013 15.7 0.0 0.062 13.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) SLIDE PF09111.10 CRG92467.1 - 0.029 14.4 0.0 0.072 13.1 0.0 1.6 1 1 0 1 1 1 0 SLIDE Myb_DNA-bind_4 PF13837.6 CRG92467.1 - 0.076 13.4 1.5 0.34 11.3 0.0 2.6 2 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain NCBP3 PF10309.9 CRG92468.1 - 7.9e-25 86.5 0.1 1.6e-24 85.5 0.1 1.5 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 Reg_prop PF07494.11 CRG92469.1 - 0.0085 16.2 0.7 0.051 13.8 0.0 2.6 2 0 0 2 2 2 1 Two component regulator propeller LisH PF08513.11 CRG92469.1 - 0.027 14.4 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 LisH ANAPC4_WD40 PF12894.7 CRG92469.1 - 0.034 14.5 0.0 0.16 12.3 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 CRG92469.1 - 0.28 12.1 6.8 3.7 8.6 0.4 4.1 4 0 0 4 4 4 0 WD domain, G-beta repeat ATP-synt_DE_N PF02823.16 CRG92470.1 - 3.9e-17 61.9 0.0 5.2e-17 61.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Phos_pyr_kin PF08543.12 CRG92471.1 - 6.5e-12 45.4 0.1 1.2e-11 44.5 0.0 1.5 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 CRG92471.1 - 1.4e-08 34.4 0.9 1e-07 31.6 0.9 2.2 1 1 0 1 1 1 1 pfkB family carbohydrate kinase FBPase_3 PF01950.16 CRG92471.1 - 0.12 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Fructose-1,6-bisphosphatase BON PF04972.17 CRG92471.1 - 0.2 12.0 1.4 0.32 11.3 0.0 2.0 2 0 0 2 2 2 0 BON domain dUTPase PF00692.19 CRG92472.1 - 7.4e-44 148.6 0.0 1.1e-43 148.0 0.0 1.3 1 0 0 1 1 1 1 dUTPase DCD PF06559.11 CRG92472.1 - 0.021 13.6 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) APH PF01636.23 CRG92473.1 - 1.2e-42 146.5 0.7 1.7e-42 146.0 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG92473.1 - 9.8e-05 22.0 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 CRG92473.1 - 0.00074 18.9 0.0 0.0014 18.0 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase RIO1 PF01163.22 CRG92473.1 - 0.019 14.6 0.0 0.09 12.4 0.0 1.9 2 0 0 2 2 2 0 RIO1 family Fructosamin_kin PF03881.14 CRG92473.1 - 0.035 13.3 0.0 0.49 9.6 0.0 2.2 1 1 1 2 2 2 0 Fructosamine kinase zf-C2H2 PF00096.26 CRG92474.1 - 2.7e-07 30.6 12.7 0.046 14.2 2.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG92474.1 - 0.022 15.6 11.7 0.035 14.9 2.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 CRG92474.1 - 0.11 13.0 0.4 0.11 13.0 0.4 4.0 4 0 0 4 4 4 0 Zinc-finger double domain zf-Di19 PF05605.12 CRG92474.1 - 1.3 9.4 9.5 0.09 13.1 1.1 2.6 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 CRG92475.1 - 0.00028 21.2 0.1 0.00028 21.2 0.1 4.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG92475.1 - 0.099 13.5 0.1 0.099 13.5 0.1 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger PQ-loop PF04193.14 CRG92476.1 - 2e-33 113.9 13.4 1.1e-17 63.5 2.8 2.8 3 0 0 3 3 3 2 PQ loop repeat ATG27 PF09451.10 CRG92476.1 - 0.083 12.7 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 Autophagy-related protein 27 Cytochrom_B561 PF03188.16 CRG92477.1 - 1.1e-07 32.0 6.3 2.5e-07 30.9 6.3 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 Gly-zipper_YMGG PF13441.6 CRG92477.1 - 0.00056 19.6 2.4 0.00056 19.6 2.4 3.8 3 1 0 3 3 3 1 YMGG-like Gly-zipper Shadoo PF14999.6 CRG92477.1 - 0.0017 18.5 4.5 0.0017 18.5 4.5 4.1 3 1 1 4 4 4 1 Shadow of prion protein, neuroprotective COX15-CtaA PF02628.15 CRG92477.1 - 0.026 13.6 8.1 0.0085 15.2 4.6 1.8 1 1 1 2 2 2 0 Cytochrome oxidase assembly protein DUF202 PF02656.15 CRG92477.1 - 1 9.8 17.3 1.3 9.5 3.8 4.6 4 1 2 6 6 6 0 Domain of unknown function (DUF202) PIG-P PF08510.12 CRG92477.1 - 3.7 7.5 5.5 10 6.0 5.5 1.7 1 0 0 1 1 1 0 PIG-P Fungal_trans PF04082.18 CRG92478.1 - 1.6e-19 70.0 0.3 4.2e-19 68.6 0.3 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Endostatin PF06482.11 CRG92478.1 - 0.01 15.3 4.6 0.019 14.4 4.6 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 CRG92478.1 - 0.45 8.6 3.3 0.68 8.0 3.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCDC53 PF10152.9 CRG92478.1 - 4.6 7.6 12.3 10 6.5 5.4 2.5 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Lin-8 PF03353.15 CRG92478.1 - 7.8 6.0 10.0 14 5.1 10.0 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Afi1 PF07792.12 CRG92479.1 - 6.1e-47 159.4 4.3 1.1e-46 158.6 4.3 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 CRG92479.1 - 3.1e-36 123.8 0.0 5.4e-36 123.0 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 CRG92479.1 - 1.6e-07 30.4 0.0 0.017 13.9 0.0 4.1 3 1 1 4 4 4 2 Transport protein Avl9 Fungal_trans PF04082.18 CRG92479.1 - 0.00016 20.8 0.0 0.00029 20.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain BUD22 PF09073.10 CRG92479.1 - 0.0012 18.2 7.0 0.0021 17.5 7.0 1.2 1 0 0 1 1 1 1 BUD22 Cwf_Cwc_15 PF04889.12 CRG92479.1 - 0.049 13.4 20.7 0.083 12.6 20.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF1168 PF06658.12 CRG92479.1 - 0.086 12.7 12.8 0.17 11.7 12.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) PPP4R2 PF09184.11 CRG92479.1 - 0.63 9.6 13.7 13 5.3 15.8 1.9 2 0 0 2 2 2 0 PPP4R2 Tub_N PF16322.5 CRG92479.1 - 1.1 9.6 10.6 0.071 13.5 5.0 1.8 2 0 0 2 2 2 0 Tubby N-terminal SDA1 PF05285.12 CRG92479.1 - 5 6.5 16.0 10 5.4 16.0 1.4 1 0 0 1 1 1 0 SDA1 Sulfatase PF00884.23 CRG92480.1 - 1.1e-68 232.0 0.0 1.3e-68 231.7 0.0 1.1 1 0 0 1 1 1 1 Sulfatase DUF4976 PF16347.5 CRG92480.1 - 0.0045 17.2 0.0 0.018 15.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Sulfatase_C PF14707.6 CRG92480.1 - 0.044 14.5 0.0 0.18 12.5 0.0 2.1 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 CRG92480.1 - 0.073 13.0 0.0 0.29 11.1 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function Phosphodiest PF01663.22 CRG92480.1 - 0.076 12.6 0.0 0.85 9.1 0.0 2.1 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase Sugar_tr PF00083.24 CRG92481.1 - 2.3e-93 313.5 22.4 1.1e-56 192.7 3.0 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 CRG92481.1 - 6.8e-22 77.9 25.6 3.7e-15 55.7 3.6 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily EF-hand_6 PF13405.6 CRG92482.1 - 3.9e-13 48.2 1.3 3.2e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 CRG92482.1 - 3.2e-10 38.8 2.4 0.0004 19.7 0.3 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 CRG92482.1 - 6.4e-09 36.1 2.8 1.4e-06 28.7 0.7 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 CRG92482.1 - 1.3e-06 27.6 4.7 0.0084 15.6 0.5 2.3 2 0 0 2 2 2 2 EF hand EF-hand_9 PF14658.6 CRG92482.1 - 0.00034 20.9 0.0 1.4 9.3 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 CRG92482.1 - 0.0019 18.0 0.0 2.1 8.3 0.0 2.5 3 0 0 3 3 3 2 EF-hand domain pair RabGAP-TBC PF00566.18 CRG92483.1 - 1.4e-28 100.0 0.0 1.1e-27 97.1 0.0 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_S8 PF00082.22 CRG92483.1 - 0.014 14.7 0.9 0.021 14.1 0.9 1.2 1 0 0 1 1 1 0 Subtilase family SET PF00856.28 CRG92484.1 - 5.9e-08 33.3 0.0 1.8e-06 28.5 0.0 3.0 3 1 0 3 3 3 1 SET domain TPR_9 PF13371.6 CRG92484.1 - 0.035 14.3 0.1 0.094 12.9 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG92484.1 - 0.18 12.7 2.5 2.1 9.4 0.6 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-MYND PF01753.18 CRG92484.1 - 3.7 7.7 16.4 0.094 12.8 9.4 2.1 2 0 0 2 2 2 0 MYND finger WD40 PF00400.32 CRG92485.1 - 7.9e-21 74.0 10.8 3e-05 24.7 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG92485.1 - 0.0001 22.5 0.0 0.056 13.8 0.0 3.6 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 CRG92485.1 - 1 8.7 12.3 2.5 7.4 12.3 1.6 1 0 0 1 1 1 0 SDA1 ETF_QO PF05187.13 CRG92486.1 - 2.4e-47 159.3 0.4 5.1e-47 158.3 0.4 1.6 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 CRG92486.1 - 2.1e-07 30.8 0.3 0.00077 19.1 0.5 2.5 1 1 1 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG92486.1 - 3.3e-06 27.2 0.0 9.6e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG92486.1 - 2.5e-05 23.6 0.2 0.003 16.7 0.7 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG92486.1 - 4.5e-05 22.8 0.0 0.00012 21.5 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG92486.1 - 5.3e-05 22.7 3.2 0.0005 19.5 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 CRG92486.1 - 0.00077 18.3 0.5 0.0013 17.5 0.5 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 CRG92486.1 - 0.0017 18.9 0.1 1.5 9.5 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG92486.1 - 0.0018 17.6 0.1 0.0037 16.6 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Phage_min_cap2 PF06152.11 CRG92486.1 - 0.002 17.1 1.3 0.0039 16.2 1.3 1.4 1 0 0 1 1 1 1 Phage minor capsid protein 2 Thi4 PF01946.17 CRG92486.1 - 0.0025 17.1 0.0 0.016 14.5 0.1 1.9 2 0 0 2 2 2 1 Thi4 family NAD_binding_9 PF13454.6 CRG92486.1 - 0.0025 17.8 0.1 0.0089 16.0 0.1 2.0 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 CRG92486.1 - 0.013 14.7 0.7 0.023 14.0 0.7 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 CRG92486.1 - 0.024 13.5 0.0 0.36 9.6 0.2 2.2 1 1 1 2 2 2 0 Tryptophan halogenase Fer4_7 PF12838.7 CRG92486.1 - 0.041 14.5 0.7 0.15 12.7 0.7 2.0 1 0 0 1 1 1 0 4Fe-4S dicluster domain Lycopene_cycl PF05834.12 CRG92486.1 - 0.13 11.2 0.3 0.22 10.5 0.3 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein GIDA PF01134.22 CRG92486.1 - 0.18 10.8 0.2 0.38 9.8 0.2 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A TBP PF00352.21 CRG92487.1 - 1.2e-67 223.8 0.1 9.2e-33 112.1 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 CRG92487.1 - 6e-05 23.1 0.0 0.22 11.6 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 CRG92487.1 - 0.13 12.1 0.1 0.68 9.8 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) DAO PF01266.24 CRG92488.1 - 4.8e-48 164.5 1.3 5.5e-48 164.3 1.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase GMC_oxred_N PF00732.19 CRG92488.1 - 4.8e-07 29.4 0.1 0.0016 17.9 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase Pyr_redox_2 PF07992.14 CRG92488.1 - 2.8e-06 26.8 0.0 9.6e-05 21.7 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG92488.1 - 3.1e-06 26.5 1.7 3.2e-05 23.2 1.7 2.0 1 1 0 1 1 1 1 FAD binding domain GIDA PF01134.22 CRG92488.1 - 2e-05 23.8 0.0 0.00015 21.0 0.0 1.9 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 CRG92488.1 - 8.7e-05 22.6 0.4 0.22 11.5 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 CRG92488.1 - 0.00012 21.4 0.0 0.051 12.8 0.0 2.2 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 CRG92488.1 - 0.00033 21.2 0.0 0.27 11.8 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG92488.1 - 0.00057 20.1 0.0 0.0015 18.8 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 CRG92488.1 - 0.0023 16.9 0.1 0.078 11.8 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.12 CRG92488.1 - 0.0058 15.7 0.1 0.011 14.8 0.0 1.5 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 CRG92488.1 - 0.0067 15.7 0.0 1 8.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG92488.1 - 0.021 14.1 0.0 0.3 10.3 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain HI0933_like PF03486.14 CRG92488.1 - 0.14 10.8 0.0 13 4.3 0.0 2.3 2 0 0 2 2 2 0 HI0933-like protein Methyltransf_23 PF13489.6 CRG92489.1 - 2.6e-33 115.2 0.0 3.5e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92489.1 - 8.6e-07 29.6 0.0 4.3e-06 27.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG92489.1 - 3e-06 27.9 0.0 5.1e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92489.1 - 0.0005 19.9 0.0 0.00081 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92489.1 - 0.0023 18.5 0.0 0.0076 16.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG92489.1 - 0.15 11.3 0.0 0.36 10.1 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family LRR19-TM PF15176.6 CRG92490.1 - 0.69 9.9 0.0 0.69 9.9 0.0 2.2 2 1 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Cyclin_N PF00134.23 CRG92491.1 - 8e-15 54.7 0.1 1.6e-14 53.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 CRG92491.1 - 0.00014 21.9 0.0 0.0018 18.3 0.0 2.5 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 CRG92491.1 - 0.01 15.8 0.6 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Transcription factor TFIIB repeat EAF PF09816.9 CRG92492.1 - 2.8e-18 66.2 0.2 8.5e-18 64.6 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor Ras PF00071.22 CRG92492.1 - 0.0015 18.1 0.0 0.003 17.2 0.0 1.4 1 0 0 1 1 1 1 Ras family Big_3_2 PF12245.8 CRG92492.1 - 0.038 14.2 0.2 0.085 13.1 0.2 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain LIN37 PF15306.6 CRG92492.1 - 5.6 7.2 18.4 1.2 9.4 0.7 2.9 3 1 0 3 3 3 0 LIN37 Dor1 PF04124.12 CRG92493.1 - 9.8e-54 182.3 2.1 4.5e-42 144.0 2.2 2.5 3 0 0 3 3 3 2 Dor1-like family Vps51 PF08700.11 CRG92493.1 - 0.036 14.2 2.7 0.042 13.9 0.8 2.2 2 0 0 2 2 2 0 Vps51/Vps67 His_Phos_1 PF00300.22 CRG92494.1 - 7.6e-29 100.8 0.0 1.8e-28 99.6 0.0 1.7 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 CRG92494.1 - 0.004 16.6 0.0 0.0084 15.5 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Cyclin PF08613.11 CRG92495.1 - 3.4e-11 43.8 0.0 5.5e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 CRG92495.1 - 0.00021 21.1 0.0 0.00035 20.3 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2380 PF09533.10 CRG92495.1 - 0.095 12.3 0.2 0.19 11.3 0.2 1.5 1 0 0 1 1 1 0 Predicted lipoprotein of unknown function (DUF2380) CRC_subunit PF08624.10 CRG92496.1 - 4.5e-52 176.1 0.1 6.5e-52 175.5 0.1 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Trypan_PARP PF05887.11 CRG92496.1 - 0.32 11.0 30.5 0.032 14.2 25.7 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 CRG92497.1 - 3.1e-69 233.3 0.0 4.1e-69 232.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92497.1 - 3e-31 108.6 0.0 4.1e-31 108.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 CRG92497.1 - 4.4e-13 49.7 0.8 4.4e-13 49.7 0.8 2.7 3 0 0 3 3 3 1 Protein kinase C terminal domain Kinase-like PF14531.6 CRG92497.1 - 9e-09 35.0 0.0 3.5e-08 33.1 0.0 1.8 1 1 0 2 2 2 1 Kinase-like C2 PF00168.30 CRG92497.1 - 1.4e-08 35.0 0.0 1.2e-05 25.6 0.0 2.7 2 0 0 2 2 2 2 C2 domain Haspin_kinase PF12330.8 CRG92497.1 - 0.00016 20.7 0.0 0.00031 19.8 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 CRG92497.1 - 0.0022 17.9 0.0 0.0038 17.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 CRG92497.1 - 0.02 14.5 1.0 2.7 7.6 0.1 2.8 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 CRG92497.1 - 0.066 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CRG92497.1 - 0.088 12.1 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Adeno_E3_15_3 PF03307.14 CRG92497.1 - 0.16 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region F-box-like PF12937.7 CRG92499.1 - 0.27 11.2 1.4 0.39 10.6 0.1 2.1 2 0 0 2 2 2 0 F-box-like AAA PF00004.29 CRG92500.1 - 1.4e-40 138.8 0.0 3.2e-40 137.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 CRG92500.1 - 6.7e-19 67.6 0.3 1.4e-18 66.6 0.3 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 CRG92500.1 - 1.3e-08 34.5 0.0 3.2e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 CRG92500.1 - 0.00018 21.5 0.9 0.00075 19.5 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 CRG92500.1 - 0.00022 21.6 1.7 0.025 14.9 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 CRG92500.1 - 0.00054 19.7 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CRG92500.1 - 0.00059 20.0 1.4 0.0094 16.1 0.0 3.2 3 1 0 3 3 3 1 AAA domain (Cdc48 subfamily) CLZ PF16526.5 CRG92500.1 - 0.0007 19.9 7.1 0.0007 19.9 7.1 2.4 2 0 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PhoH PF02562.16 CRG92500.1 - 0.0041 16.6 0.2 0.068 12.6 0.1 2.4 2 0 0 2 2 2 1 PhoH-like protein Mg_chelatase PF01078.21 CRG92500.1 - 0.0049 16.3 0.2 0.014 14.8 0.1 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 CRG92500.1 - 0.024 13.8 0.0 0.068 12.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 CRG92500.1 - 0.037 14.2 0.0 0.12 12.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CRG92500.1 - 0.054 13.8 5.3 0.29 11.4 0.0 3.1 3 1 1 4 4 4 0 AAA domain TMF_TATA_bd PF12325.8 CRG92500.1 - 0.067 13.4 5.0 0.048 13.9 1.9 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding IstB_IS21 PF01695.17 CRG92500.1 - 0.076 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 CRG92500.1 - 0.098 12.2 0.1 0.33 10.4 0.0 2.0 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 CRG92500.1 - 0.13 12.0 0.5 0.45 10.2 0.1 2.2 2 1 0 2 2 1 0 AAA domain AAA_11 PF13086.6 CRG92500.1 - 0.2 11.4 4.3 0.47 10.2 0.0 2.8 2 1 0 3 3 3 0 AAA domain HIP1_clath_bdg PF16515.5 CRG92500.1 - 8.3 7.1 11.8 0.92 10.2 3.1 3.0 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TauD PF02668.16 CRG92501.1 - 2.8e-40 138.8 0.1 4e-40 138.3 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 CRG92501.1 - 1.8e-13 50.9 0.0 5e-13 49.5 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 CRG92501.1 - 0.044 12.9 0.1 0.31 10.1 0.0 2.0 2 0 0 2 2 2 0 CsiD DUF2442 PF10387.9 CRG92501.1 - 0.044 14.1 0.0 0.12 12.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) MaoC_dehydratas PF01575.19 CRG92502.1 - 7.5e-27 93.3 0.3 1.5e-25 89.2 0.0 2.1 2 0 0 2 2 2 1 MaoC like domain MaoC_dehydrat_N PF13452.6 CRG92502.1 - 3.5e-09 36.9 0.0 9.8e-05 22.5 0.0 2.2 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase Methyltransf_25 PF13649.6 CRG92503.1 - 1.9e-12 47.7 0.0 4.3e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 CRG92503.1 - 7.9e-11 41.9 0.0 1.3e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 CRG92503.1 - 4.3e-10 39.6 0.0 6.3e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92503.1 - 1.1e-08 35.6 0.0 2.4e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG92503.1 - 3e-06 27.2 0.0 6.4e-06 26.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 CRG92503.1 - 7.8e-06 25.0 0.1 1.2e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 CRG92503.1 - 1.4e-05 25.1 0.6 9.9e-05 22.3 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain CMAS PF02353.20 CRG92503.1 - 0.00012 21.5 0.0 0.00017 21.0 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 CRG92503.1 - 0.00043 19.9 0.0 0.00073 19.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 CRG92503.1 - 0.0006 20.5 0.0 0.0012 19.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG92503.1 - 0.0032 16.8 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 CRG92503.1 - 0.0048 17.0 0.0 0.008 16.3 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase PRMT5 PF05185.16 CRG92503.1 - 0.014 15.2 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_16 PF10294.9 CRG92503.1 - 0.015 15.0 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 CRG92503.1 - 0.018 15.0 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 CRG92503.1 - 0.057 13.2 0.2 0.094 12.4 0.2 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 CRG92503.1 - 0.13 13.3 0.0 0.28 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 CRG92503.1 - 0.17 11.5 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Per1 PF04080.13 CRG92504.1 - 6.3e-104 347.3 15.9 7.7e-104 347.0 15.9 1.1 1 0 0 1 1 1 1 Per1-like family DUF998 PF06197.13 CRG92504.1 - 0.029 14.0 5.9 0.099 12.2 5.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF998) DUF3522 PF12036.8 CRG92504.1 - 0.032 14.5 11.1 0.032 14.5 10.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3522) Syndecan PF01034.20 CRG92504.1 - 0.16 11.9 2.0 0.38 10.7 0.0 2.5 3 0 0 3 3 3 0 Syndecan domain Ldh_2 PF02615.14 CRG92505.1 - 3.7e-111 371.5 0.3 4.1e-111 371.3 0.3 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase Iso_dh PF00180.20 CRG92506.1 - 1.3e-64 218.6 0.0 1.5e-64 218.4 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PGM_PMM_I PF02878.16 CRG92507.1 - 5.1e-16 58.6 0.3 3e-07 30.2 0.0 3.2 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 CRG92507.1 - 8.7e-13 48.3 2.2 2.1e-12 47.0 1.1 2.3 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 CRG92507.1 - 0.0018 18.8 0.0 0.0079 16.8 0.0 2.2 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 CRG92507.1 - 0.0053 16.9 0.4 0.031 14.5 0.4 2.2 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III rve_3 PF13683.6 CRG92507.1 - 0.017 14.9 0.0 12 5.8 0.0 3.3 3 0 0 3 3 3 0 Integrase core domain Brix PF04427.18 CRG92508.1 - 5.1e-51 173.5 0.2 7.4e-51 173.0 0.2 1.2 1 0 0 1 1 1 1 Brix domain Lum_binding PF00677.17 CRG92509.1 - 9.9e-44 147.3 1.2 6e-22 77.4 0.3 2.3 2 0 0 2 2 2 2 Lumazine binding domain CoA_transf_3 PF02515.17 CRG92510.1 - 2.3e-126 421.9 0.0 2.6e-126 421.7 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III PHD PF00628.29 CRG92511.1 - 2.2e-09 37.1 9.2 4.1e-09 36.2 9.2 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 CRG92511.1 - 0.00094 18.7 5.0 0.00094 18.7 5.0 2.2 2 1 0 2 2 2 1 PHD-finger zf-RRPl_C4 PF17026.5 CRG92511.1 - 0.026 14.6 1.5 0.046 13.8 1.5 1.3 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type FYVE_2 PF02318.16 CRG92511.1 - 0.17 12.1 3.4 0.29 11.3 3.4 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger Prok-RING_1 PF14446.6 CRG92511.1 - 0.58 10.1 5.2 1.2 9.1 5.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 CRG92511.1 - 0.8 9.6 9.6 0.22 11.5 5.6 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 CRG92511.1 - 0.89 9.9 4.1 2.1 8.7 4.1 1.6 1 0 0 1 1 1 0 C1 domain zf-RING_7 PF02591.15 CRG92511.1 - 1.2 9.4 3.3 24 5.2 0.1 2.7 2 0 0 2 2 2 0 C4-type zinc ribbon domain Tnp_zf-ribbon_2 PF13842.6 CRG92511.1 - 6.5 7.7 8.6 31 5.5 3.9 2.6 1 1 1 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Amidohydro_1 PF01979.20 CRG92512.1 - 7e-08 32.2 0.1 9e-08 31.8 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family adh_short PF00106.25 CRG92513.1 - 2.7e-35 121.6 0.1 3.4e-35 121.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92513.1 - 3.4e-27 95.5 0.0 6.1e-27 94.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92513.1 - 4.1e-08 33.3 0.2 7.9e-08 32.4 0.2 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 CRG92513.1 - 0.0011 18.4 0.1 0.0023 17.4 0.0 1.5 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Sof1 PF04158.14 CRG92514.1 - 1.9e-31 108.2 13.9 3.4e-31 107.4 13.9 1.4 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 CRG92514.1 - 2.2e-26 91.6 3.7 9.7e-06 26.2 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG92514.1 - 4.8e-08 33.2 0.1 0.054 13.8 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 CRG92514.1 - 4.7e-05 22.5 0.0 0.016 14.2 0.0 3.0 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 CRG92514.1 - 0.0013 18.6 0.6 0.044 13.7 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 CRG92514.1 - 0.028 13.1 1.0 0.1 11.2 0.9 2.0 1 1 0 1 1 1 0 Nucleoporin Nup120/160 RPN6_N PF18055.1 CRG92515.1 - 6.9e-44 149.0 0.7 2.1e-43 147.4 0.1 2.2 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 CRG92515.1 - 1.5e-21 76.9 1.0 1.2e-20 74.0 0.1 2.5 2 1 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 CRG92515.1 - 1e-10 41.1 0.2 2.8e-10 39.8 0.2 1.8 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_MalT PF17874.1 CRG92515.1 - 1.2e-06 28.1 3.9 7.9e-06 25.5 2.5 2.5 2 1 1 3 3 3 1 MalT-like TPR region TPR_12 PF13424.6 CRG92515.1 - 1.5e-06 28.4 11.1 0.0015 18.8 0.4 4.8 4 1 0 5 5 5 2 Tetratricopeptide repeat DDRGK PF09756.9 CRG92515.1 - 1.6e-05 24.6 0.2 3e-05 23.7 0.2 1.4 1 0 0 1 1 1 1 DDRGK domain DprA_WH PF17782.1 CRG92515.1 - 0.013 15.6 0.1 0.32 11.1 0.0 2.9 3 0 0 3 3 3 0 DprA winged helix domain TPR_1 PF00515.28 CRG92515.1 - 0.032 14.1 5.7 1.8 8.5 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Prefoldin_2 PF01920.20 CRG92515.1 - 0.034 14.1 1.6 0.21 11.5 0.7 2.8 2 0 0 2 2 2 0 Prefoldin subunit HTH_Crp_2 PF13545.6 CRG92515.1 - 0.053 13.5 0.0 0.61 10.1 0.0 2.6 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain SRPRB PF09439.10 CRG92515.1 - 0.056 12.9 0.3 0.1 12.0 0.3 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TPR_7 PF13176.6 CRG92515.1 - 0.061 13.4 1.9 24 5.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat NYD-SP28 PF14772.6 CRG92515.1 - 0.11 12.6 0.3 5.4 7.1 0.0 2.7 2 0 0 2 2 2 0 Sperm tail TPR_2 PF07719.17 CRG92515.1 - 0.29 11.3 8.3 39 4.7 0.6 5.4 5 1 0 5 5 5 0 Tetratricopeptide repeat NepR PF18557.1 CRG92515.1 - 0.65 9.7 2.7 0.94 9.2 0.1 2.5 2 0 0 2 2 2 0 Anti-sigma factor NepR SbsC_C PF18058.1 CRG92515.1 - 0.78 10.0 5.3 0.55 10.5 0.7 2.6 2 0 0 2 2 2 0 SbsC C-terminal domain TPR_8 PF13181.6 CRG92515.1 - 3.3 8.2 11.1 1e+02 3.5 0.1 6.5 6 1 2 8 8 8 0 Tetratricopeptide repeat SWIB PF02201.18 CRG92516.1 - 1.9e-22 78.9 0.0 4.2e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain OrfB_IS605 PF01385.19 CRG92516.1 - 0.096 12.9 1.1 0.58 10.4 0.1 2.4 2 0 0 2 2 2 0 Probable transposase RNA_pol_Rpb2_5 PF04567.17 CRG92516.1 - 0.11 13.0 0.3 1.2 9.8 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 5 TRAM_LAG1_CLN8 PF03798.16 CRG92517.1 - 1.1e-50 172.1 12.4 1.1e-50 172.1 12.4 1.9 2 0 0 2 2 2 1 TLC domain UBA_2 PF08587.11 CRG92518.1 - 0.022 14.8 10.9 9.7 6.4 0.3 7.5 8 0 0 8 8 8 0 Ubiquitin associated domain (UBA) Fer2_BFD PF04324.15 CRG92518.1 - 0.11 12.9 4.4 6.9 7.1 0.1 5.6 6 0 0 6 6 6 0 BFD-like [2Fe-2S] binding domain Mobilization_B PF17511.2 CRG92518.1 - 1.4 9.3 5.5 0.61 10.5 0.9 2.9 3 0 0 3 3 3 0 Mobilization protein B EDR1 PF14381.6 CRG92518.1 - 8.3 6.1 8.9 1.9 8.2 0.1 3.8 3 1 0 3 3 3 0 Ethylene-responsive protein kinase Le-CTR1 Ribosomal_L27e PF01777.18 CRG92519.1 - 7e-39 132.1 3.5 1.1e-38 131.5 3.5 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 CRG92519.1 - 0.0034 17.3 0.2 0.009 15.9 0.2 1.8 1 0 0 1 1 1 1 KOW motif EthD PF07110.11 CRG92520.1 - 1.8e-05 25.8 0.3 4.5e-05 24.5 0.3 1.7 1 0 0 1 1 1 1 EthD domain Aspzincin_M35 PF14521.6 CRG92521.1 - 0.012 16.2 0.0 0.035 14.7 0.0 1.7 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase Perilipin PF03036.16 CRG92522.1 - 0.031 13.3 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Perilipin family Band_7 PF01145.25 CRG92524.1 - 5.1e-28 98.3 2.6 5.1e-28 98.3 2.6 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 CRG92524.1 - 0.071 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 SPFH domain-Band 7 family PARP PF00644.20 CRG92525.1 - 4.1e-11 42.8 1.3 8.8e-11 41.7 0.3 1.9 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain UQ_con PF00179.26 CRG92525.1 - 8.2e-09 35.2 0.0 1.9e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme THF_DHG_CYH_C PF02882.19 CRG92526.1 - 0.017 14.4 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Sigma70_ner PF04546.13 CRG92526.1 - 0.87 9.4 7.4 0.13 12.2 2.8 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region RNA_pol_Rpb4 PF03874.16 CRG92527.1 - 0.00013 22.2 0.0 0.71 10.2 0.0 2.7 2 1 0 2 2 2 2 RNA polymerase Rpb4 EBV-NA3 PF05009.12 CRG92527.1 - 0.19 11.2 1.2 0.25 10.8 1.2 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Nop PF01798.18 CRG92528.1 - 3.6e-83 278.5 0.1 3.6e-83 278.5 0.1 1.9 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 CRG92528.1 - 7.9e-23 80.6 0.6 7.9e-23 80.6 0.6 2.8 3 1 0 3 3 3 1 NOP5NT (NUC127) domain DUF3653 PF12375.8 CRG92528.1 - 0.035 14.2 0.2 26 5.0 0.0 3.3 3 0 0 3 3 3 0 Phage protein vATP-synt_AC39 PF01992.16 CRG92529.1 - 2.7e-106 355.9 0.0 3.1e-106 355.7 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Pribosyl_synth PF14572.6 CRG92530.1 - 8.6e-40 136.7 2.0 1.2e-34 120.0 0.8 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 CRG92530.1 - 7.4e-34 116.2 0.0 2.2e-33 114.6 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 CRG92530.1 - 6.4e-15 55.0 0.3 1.3e-14 54.0 0.3 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 CRG92530.1 - 0.0005 19.6 0.2 0.00086 18.8 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase ubiquitin PF00240.23 CRG92531.1 - 0.0014 18.4 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.10 CRG92531.1 - 0.0043 17.7 0.0 0.0071 17.0 0.0 1.4 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD PIG-H PF10181.9 CRG92532.1 - 1.3e-27 95.4 0.3 2.1e-27 94.7 0.3 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component PseudoU_synth_1 PF01416.20 CRG92533.1 - 1.8e-33 115.2 0.0 2.1e-32 111.8 0.0 2.6 3 0 0 3 3 3 1 tRNA pseudouridine synthase Ras PF00071.22 CRG92534.1 - 6.9e-21 74.5 0.0 1e-20 74.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 CRG92534.1 - 2.9e-08 33.9 0.0 6e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 CRG92534.1 - 0.00034 20.9 0.0 0.0006 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain G-alpha PF00503.20 CRG92534.1 - 0.00076 18.7 0.2 0.00076 18.7 0.2 1.2 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 CRG92534.1 - 0.0008 18.9 0.1 0.0085 15.6 0.1 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 CRG92534.1 - 0.0013 18.5 0.1 0.0023 17.7 0.1 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 CRG92534.1 - 0.0025 18.2 0.1 0.0037 17.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain DLIC PF05783.11 CRG92534.1 - 0.004 16.0 0.0 0.0055 15.6 0.0 1.2 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) NACHT PF05729.12 CRG92534.1 - 0.0046 16.9 0.1 0.011 15.6 0.1 1.6 2 0 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 CRG92534.1 - 0.0061 16.5 0.0 0.092 12.7 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 CRG92534.1 - 0.0075 16.8 0.0 0.0087 16.6 0.0 1.4 1 1 0 1 1 1 1 ABC transporter SRP54 PF00448.22 CRG92534.1 - 0.0094 15.6 0.5 2.3 7.8 0.1 2.7 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 CRG92534.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 CRG92534.1 - 0.014 14.9 0.1 0.04 13.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 CRG92534.1 - 0.045 14.1 0.0 0.1 13.0 0.0 1.7 1 1 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 CRG92534.1 - 0.046 14.3 0.0 0.086 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG92534.1 - 0.047 13.7 0.1 0.089 12.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 CRG92534.1 - 0.055 12.8 0.0 0.082 12.3 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MobB PF03205.14 CRG92534.1 - 0.076 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.15 CRG92534.1 - 0.079 12.9 0.0 0.14 12.1 0.0 1.4 2 0 0 2 2 2 0 Rad17 P-loop domain TniB PF05621.11 CRG92534.1 - 0.085 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Septin PF00735.18 CRG92534.1 - 0.086 12.1 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Septin AAA_33 PF13671.6 CRG92534.1 - 0.091 12.9 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 CRG92534.1 - 0.096 12.4 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family SRPRB PF09439.10 CRG92534.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 CRG92534.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 CRG92534.1 - 0.12 11.4 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain AAA_29 PF13555.6 CRG92534.1 - 0.14 11.9 0.6 0.25 11.1 0.1 1.7 2 0 0 2 2 1 0 P-loop containing region of AAA domain TsaE PF02367.17 CRG92534.1 - 0.17 11.9 0.2 0.56 10.2 0.1 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 CRG92534.1 - 0.2 11.1 0.0 0.38 10.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein Ribosomal_S2 PF00318.20 CRG92535.1 - 2.1e-26 92.5 0.2 6.3e-15 55.0 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 CRG92535.1 - 1.2e-08 36.2 12.3 2.2e-08 35.4 12.3 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ribosomal_S15 PF00312.22 CRG92536.1 - 1.9e-27 95.3 0.9 7.1e-27 93.4 0.5 2.2 2 0 0 2 2 2 1 Ribosomal protein S15 DDE_Tnp_1_6 PF13751.6 CRG92537.1 - 0.0034 17.6 0.4 0.0097 16.1 0.4 1.8 1 0 0 1 1 1 1 Transposase DDE domain DUF2526 PF10735.9 CRG92537.1 - 0.74 10.0 3.5 1 9.5 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2526) DEAD PF00270.29 CRG92538.1 - 1.5e-36 125.8 0.0 1.3e-35 122.8 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 CRG92538.1 - 6.7e-22 77.9 0.0 2e-21 76.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 CRG92538.1 - 1.2e-19 70.2 0.1 2.4e-19 69.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 CRG92538.1 - 0.0024 17.9 0.0 0.0086 16.1 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 CRG92538.1 - 6.8 6.4 8.6 8.2 6.1 7.2 2.0 2 0 0 2 2 2 0 AAA domain XPG_I PF00867.18 CRG92540.1 - 1.8e-24 85.9 0.1 1.4e-23 83.0 0.0 2.4 3 0 0 3 3 3 1 XPG I-region GEN1_C PF18380.1 CRG92540.1 - 2.1e-19 70.4 0.0 2.1e-19 70.4 0.0 2.9 2 1 1 3 3 3 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 CRG92540.1 - 2.5e-07 31.1 0.0 6.1e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain Actin PF00022.19 CRG92541.1 - 1.5e-26 93.0 0.0 7.1e-25 87.5 0.0 2.8 2 1 0 2 2 2 1 Actin MreB_Mbl PF06723.13 CRG92541.1 - 0.089 11.6 0.0 0.19 10.5 0.0 1.5 2 0 0 2 2 2 0 MreB/Mbl protein Aldose_epim PF01263.20 CRG92542.1 - 1.7e-49 168.8 0.4 2.3e-49 168.4 0.4 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase SDA1 PF05285.12 CRG92543.1 - 9.1e-05 22.0 13.2 9.1e-05 22.0 13.2 3.6 2 1 1 3 3 3 1 SDA1 HNF-1A_C PF04813.12 CRG92543.1 - 1.3 9.9 4.9 1 10.2 1.5 2.7 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus AAA_23 PF13476.6 CRG92543.1 - 1.3 9.5 22.4 1.8 9.0 5.1 2.5 2 0 0 2 2 2 0 AAA domain DDHD PF02862.17 CRG92543.1 - 1.4 9.1 12.4 6 7.0 1.2 2.7 2 0 0 2 2 2 0 DDHD domain AT_hook PF02178.19 CRG92543.1 - 1.9 8.6 23.6 1.6 8.8 5.7 3.4 3 0 0 3 3 3 0 AT hook motif Pkinase PF00069.25 CRG92544.1 - 2.4e-08 33.7 0.0 2.8e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92544.1 - 4.5e-05 22.9 0.0 0.0003 20.2 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Glyco_hydro_72 PF03198.14 CRG92545.1 - 1.1e-94 317.2 0.1 1.5e-94 316.8 0.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 CRG92545.1 - 0.2 10.7 0.0 0.33 10.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Sds3 PF08598.11 CRG92548.1 - 4.8e-45 154.2 1.6 8.1e-43 147.0 0.0 2.4 1 1 1 2 2 2 1 Sds3-like NACHT PF05729.12 CRG92548.1 - 9.3e-07 28.9 0.0 2.7e-06 27.4 0.0 1.9 1 0 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 CRG92548.1 - 0.00067 19.7 0.0 0.002 18.1 0.0 1.8 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CRG92548.1 - 0.0015 18.8 0.0 0.0065 16.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain SesA PF17107.5 CRG92548.1 - 0.0024 18.1 0.0 0.0049 17.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases AAA_16 PF13191.6 CRG92548.1 - 0.0026 18.2 0.0 0.035 14.5 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain Helo_like_N PF17111.5 CRG92548.1 - 0.0092 15.4 0.2 0.023 14.1 0.2 1.6 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins ABC_tran PF00005.27 CRG92548.1 - 0.013 16.0 0.1 0.15 12.6 0.0 2.7 3 0 0 3 3 2 0 ABC transporter AAA_29 PF13555.6 CRG92548.1 - 0.016 14.9 0.0 0.054 13.3 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 CRG92548.1 - 0.04 14.5 0.0 0.17 12.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain DUF2383 PF09537.10 CRG92548.1 - 0.043 14.2 0.0 0.17 12.2 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) Zeta_toxin PF06414.12 CRG92548.1 - 0.045 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 CRG92548.1 - 0.076 13.4 0.0 0.29 11.6 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 CRG92548.1 - 0.092 13.1 0.0 0.32 11.4 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.18 CRG92548.1 - 0.097 12.4 0.0 0.29 10.8 0.0 1.8 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 CRG92548.1 - 0.18 11.4 0.0 0.42 10.2 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FAD_binding_3 PF01494.19 CRG92549.1 - 3e-08 33.3 3.1 8.6e-07 28.5 3.1 2.7 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG92549.1 - 0.00014 21.2 0.9 0.00036 19.8 0.3 1.7 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 CRG92549.1 - 0.0007 19.8 0.1 0.0007 19.8 0.1 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 CRG92549.1 - 0.001 17.8 0.4 0.0022 16.8 0.4 1.5 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 CRG92549.1 - 0.0049 16.1 0.4 0.0082 15.4 0.4 1.3 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 CRG92549.1 - 0.0053 16.4 0.6 0.01 15.5 0.6 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 CRG92549.1 - 0.017 14.4 0.7 0.029 13.6 0.7 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 CRG92549.1 - 0.028 14.4 0.2 0.064 13.2 0.2 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 CRG92549.1 - 0.11 11.5 0.2 0.17 10.9 0.2 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 CRG92549.1 - 0.16 11.0 0.4 0.27 10.3 0.4 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 CRG92549.1 - 0.19 10.6 1.1 0.27 10.0 0.3 1.6 2 0 0 2 2 2 0 Tryptophan halogenase MR_MLE_C PF13378.6 CRG92550.1 - 1.8e-51 174.9 0.1 2.8e-51 174.2 0.1 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 CRG92550.1 - 0.005 16.0 0.0 0.0078 15.4 0.0 1.3 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus MR_MLE_N PF02746.16 CRG92550.1 - 0.0075 16.5 0.0 0.016 15.4 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Enolase_C PF00113.22 CRG92550.1 - 0.1 11.8 0.0 0.21 10.8 0.0 1.4 2 0 0 2 2 2 0 Enolase, C-terminal TIM barrel domain Sugar_tr PF00083.24 CRG92551.1 - 4e-101 339.1 12.4 5.7e-101 338.6 12.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Ank_2 PF12796.7 CRG92551.1 - 1.6e-27 95.9 4.7 1e-13 51.6 0.1 5.6 2 2 2 5 5 5 3 Ankyrin repeats (3 copies) MFS_1 PF07690.16 CRG92551.1 - 1.6e-21 76.6 9.1 1.6e-21 76.6 9.1 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Ank_4 PF13637.6 CRG92551.1 - 3e-21 75.5 1.4 2.9e-07 30.9 0.1 5.8 4 1 2 6 6 5 4 Ankyrin repeats (many copies) SPRY PF00622.28 CRG92551.1 - 9.4e-21 74.2 0.0 2.4e-20 72.8 0.0 1.8 1 0 0 1 1 1 1 SPRY domain Ank_3 PF13606.6 CRG92551.1 - 2.4e-16 58.1 3.4 0.0097 16.4 0.1 8.2 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 CRG92551.1 - 4.7e-13 49.1 3.9 4.1e-05 23.8 0.3 4.5 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Epimerase PF01370.21 CRG92551.1 - 4.6e-12 45.9 0.0 1.2e-11 44.5 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 CRG92551.1 - 3.6e-11 42.6 0.0 5.9e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 CRG92551.1 - 2e-09 37.6 0.0 3.9e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Ank PF00023.30 CRG92551.1 - 4.6e-09 36.3 4.6 0.0017 18.7 0.2 4.7 5 0 0 5 5 3 2 Ankyrin repeat NAD_binding_4 PF07993.12 CRG92551.1 - 2.5e-08 33.4 0.0 0.0017 17.6 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein NmrA PF05368.13 CRG92551.1 - 1.7e-07 31.0 0.1 4.5e-07 29.7 0.1 1.7 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 CRG92551.1 - 1.2e-05 25.0 0.0 1.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 CRG92551.1 - 0.00062 19.0 0.0 0.0031 16.7 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 CRG92551.1 - 0.002 18.0 0.0 0.0069 16.3 0.0 1.8 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 CRG92551.1 - 0.003 17.0 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 CRG92551.1 - 0.1 11.7 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Hemerythrin PF01814.23 CRG92553.1 - 3.8e-14 53.4 0.1 5.5e-14 52.9 0.1 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain TCTP PF00838.17 CRG92553.1 - 0.027 14.8 0.0 0.033 14.5 0.0 1.2 1 0 0 1 1 1 0 Translationally controlled tumour protein Dynamin_M PF01031.20 CRG92553.1 - 0.079 12.2 1.0 0.16 11.2 1.1 1.4 1 1 0 1 1 1 0 Dynamin central region Phage_int_SAM_5 PF13102.6 CRG92553.1 - 0.12 12.8 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Phage integrase SAM-like domain DUF3433 PF11915.8 CRG92554.1 - 2.2e-44 149.8 16.5 4.9e-24 84.6 0.6 3.7 3 0 0 3 3 3 2 Protein of unknown function (DUF3433) CFEM PF05730.11 CRG92555.1 - 0.00012 22.1 5.6 0.00012 22.1 5.6 2.8 2 0 0 2 2 2 1 CFEM domain DUF4687 PF15747.5 CRG92557.1 - 0.066 13.7 1.7 0.23 12.0 1.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4687) Adaptin_binding PF10199.9 CRG92557.1 - 2.2 8.9 6.3 5.4 7.6 4.8 2.4 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Sep15_SelM PF08806.11 CRG92558.1 - 0.094 12.9 0.4 2.6 8.3 0.1 2.4 2 0 0 2 2 2 0 Sep15/SelM redox domain GvpG PF05120.12 CRG92559.1 - 0.13 12.3 3.4 0.18 11.8 0.8 2.6 2 1 1 3 3 3 0 Gas vesicle protein G PQQ PF01011.21 CRG92559.1 - 0.15 12.1 0.4 2.8 8.0 0.1 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat BTB PF00651.31 CRG92560.1 - 2e-07 31.2 0.0 1.3e-06 28.7 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Skp1_POZ PF03931.15 CRG92560.1 - 0.0011 19.1 0.0 0.0021 18.2 0.0 1.4 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Drf_GBD PF06371.13 CRG92561.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain CCDC92 PF14916.6 CRG92561.1 - 0.21 11.4 0.6 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain of unknown function UQ_con PF00179.26 CRG92562.1 - 2.3e-34 118.0 0.0 1.9e-25 89.2 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Peptidase_S24 PF00717.23 CRG92562.1 - 2e-07 30.9 0.0 4.5e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase S24-like Prok-E2_B PF14461.6 CRG92562.1 - 1.8e-05 24.4 0.0 3.7e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B TauD PF02668.16 CRG92563.1 - 6.1e-48 163.9 0.4 7.3e-48 163.7 0.4 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CRG92564.1 - 2.2e-37 128.8 35.1 2.2e-37 128.8 35.1 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily SPC12 PF06645.13 CRG92564.1 - 0.5 10.5 4.9 2.1 8.5 0.1 3.2 2 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DHDPS PF00701.22 CRG92565.1 - 6.1e-31 107.2 0.0 2.1e-30 105.4 0.0 1.7 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family Fungal_trans PF04082.18 CRG92565.1 - 1.4e-22 80.0 2.0 2.3e-22 79.3 2.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92565.1 - 1.1e-06 28.6 9.9 2.3e-06 27.6 9.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TauD PF02668.16 CRG92566.1 - 7.3e-49 167.0 0.1 8.6e-49 166.7 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family MFS_1 PF07690.16 CRG92567.1 - 6.5e-30 104.2 27.2 6.5e-30 104.2 27.2 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2614 PF11023.8 CRG92567.1 - 0.11 12.6 2.0 0.63 10.2 0.0 2.6 2 0 0 2 2 2 0 Zinc-ribbon containing domain PTP_tm PF18861.1 CRG92568.1 - 0.0025 17.8 0.1 0.0037 17.3 0.1 1.3 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J Syndecan PF01034.20 CRG92568.1 - 0.0054 16.6 1.4 0.0096 15.8 1.4 1.3 1 0 0 1 1 1 1 Syndecan domain Amnionless PF14828.6 CRG92568.1 - 0.012 14.5 0.0 0.015 14.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless Insulin_TMD PF17870.1 CRG92568.1 - 0.1 12.7 0.3 0.18 11.9 0.3 1.3 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment S1FA PF04689.13 CRG92568.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 DNA binding protein S1FA DAP10 PF07213.11 CRG92568.1 - 0.17 11.9 0.2 0.17 11.9 0.2 1.7 2 0 0 2 2 2 0 DAP10 membrane protein DUF4690 PF15756.5 CRG92568.1 - 3.3 8.4 9.6 1.2 9.8 5.8 2.1 1 1 1 2 2 2 0 Small Novel Rich in Cartilage Dehydrin PF00257.19 CRG92568.1 - 4.4 7.8 10.3 6.2 7.4 10.3 1.2 1 0 0 1 1 1 0 Dehydrin Kinesin PF00225.23 CRG92569.1 - 2e-55 188.0 0.0 2.5e-32 112.1 0.0 2.1 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 CRG92569.1 - 8.5e-11 42.0 0.0 2.2e-10 40.7 0.0 1.7 2 0 0 2 2 2 1 Microtubule binding adh_short PF00106.25 CRG92570.1 - 1.4e-35 122.6 0.4 1.9e-35 122.1 0.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92570.1 - 1.1e-28 100.4 0.1 1.3e-28 100.2 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92570.1 - 1.1e-11 45.0 1.0 1.4e-11 44.6 1.0 1.1 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 CRG92570.1 - 0.022 13.8 0.0 0.026 13.5 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family P3A PF08727.11 CRG92571.1 - 0.022 14.1 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Poliovirus 3A protein like RabGAP-TBC PF00566.18 CRG92572.1 - 5.9e-33 114.3 0.0 4.5e-32 111.5 0.0 2.2 1 1 0 1 1 1 1 Rab-GTPase-TBC domain CFEM PF05730.11 CRG92573.1 - 0.00046 20.2 11.0 0.00046 20.2 11.0 1.9 2 0 0 2 2 2 1 CFEM domain Arylsulfotran_2 PF14269.6 CRG92575.1 - 3.4e-57 194.1 3.8 4.7e-57 193.6 3.8 1.2 1 0 0 1 1 1 1 Arylsulfotransferase (ASST) Arylsulfotrans PF05935.11 CRG92575.1 - 2.1e-16 59.9 6.2 7.9e-16 57.9 6.2 1.8 1 1 0 1 1 1 1 Arylsulfotransferase (ASST) Plasmodium_Vir PF05795.11 CRG92575.1 - 0.036 13.5 0.2 0.053 12.9 0.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein BCS1_N PF08740.11 CRG92576.1 - 6e-47 160.0 1.7 8.2e-47 159.6 1.7 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CRG92576.1 - 8.7e-18 65.0 0.0 1.5e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG92576.1 - 1.4e-05 25.5 0.0 3.8e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 CRG92576.1 - 0.001 18.3 0.0 0.002 17.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_21 PF13304.6 CRG92576.1 - 0.0014 18.5 0.0 0.0025 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 CRG92576.1 - 0.0041 16.7 0.0 0.24 11.0 0.0 2.6 2 1 1 3 3 3 1 AAA domain AAA_29 PF13555.6 CRG92576.1 - 0.0075 16.0 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 CRG92576.1 - 0.0085 16.6 0.0 0.017 15.6 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 CRG92576.1 - 0.011 15.8 0.0 0.043 13.8 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 CRG92576.1 - 0.019 15.5 0.0 0.038 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 CRG92576.1 - 0.022 14.5 0.0 0.11 12.2 0.0 2.0 1 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 CRG92576.1 - 0.022 15.1 0.0 0.061 13.7 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_7 PF12775.7 CRG92576.1 - 0.026 14.0 0.0 0.063 12.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 CRG92576.1 - 0.028 14.6 0.0 0.061 13.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 CRG92576.1 - 0.063 13.5 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 CRG92576.1 - 0.1 12.7 0.0 0.23 11.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Rad17 PF03215.15 CRG92576.1 - 0.12 12.2 0.0 0.52 10.2 0.0 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain PPV_E1_C PF00519.17 CRG92576.1 - 0.2 10.5 0.0 0.31 9.8 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase ATPase PF06745.13 CRG92576.1 - 0.21 10.9 0.0 0.37 10.1 0.0 1.3 1 0 0 1 1 1 0 KaiC Cpn60_TCP1 PF00118.24 CRG92577.1 - 5.4e-176 586.0 1.2 6.5e-176 585.8 1.2 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF1168 PF06658.12 CRG92578.1 - 4.6e-41 139.8 15.4 6.5e-41 139.3 15.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Lyase_catalyt PF09093.11 CRG92578.1 - 0.012 14.8 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Lyase, catalytic PPL5 PF18168.1 CRG92578.1 - 0.038 13.3 4.4 0.053 12.8 4.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 ATP-synt_E PF05680.12 CRG92578.1 - 0.63 10.4 7.9 1.7 9.1 7.9 1.8 1 0 0 1 1 1 0 ATP synthase E chain Presenilin PF01080.17 CRG92578.1 - 2.9 6.6 7.5 3.7 6.2 7.5 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 CRG92578.1 - 4.3 7.4 8.9 6.8 6.7 8.9 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal NARP1 PF12569.8 CRG92578.1 - 9.9 4.9 15.2 13 4.5 15.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 UQ_con PF00179.26 CRG92579.1 - 4.2e-22 78.3 0.0 7.1e-22 77.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-PARP PF00645.18 CRG92580.1 - 8.5e-22 77.8 0.0 3.1e-21 76.0 0.0 2.0 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SWI-SNF_Ssr4 PF08549.10 CRG92580.1 - 0.029 13.0 24.0 0.037 12.7 24.0 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) RTA1 PF04479.13 CRG92581.1 - 3.3e-39 134.6 5.6 4.2e-39 134.3 5.6 1.1 1 0 0 1 1 1 1 RTA1 like protein Kinesin PF00225.23 CRG92582.1 - 6e-59 199.6 0.0 8.7e-59 199.1 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 CRG92582.1 - 1.5e-11 44.4 0.1 2.1e-10 40.7 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding Med21 PF11221.8 CRG92582.1 - 1 9.6 8.1 0.14 12.4 0.7 2.9 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Stathmin PF00836.19 CRG92582.1 - 3.3 7.7 10.6 1.1 9.2 7.2 1.9 2 0 0 2 2 2 0 Stathmin family DUF3452 PF11934.8 CRG92583.1 - 0.12 11.9 0.2 1.3 8.6 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3452) TPR_1 PF00515.28 CRG92583.1 - 0.15 11.9 3.3 5.4 7.0 0.2 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat FAT PF02259.23 CRG92583.1 - 0.18 11.0 4.4 0.52 9.5 0.1 3.1 3 0 0 3 3 3 0 FAT domain TPR_11 PF13414.6 CRG92583.1 - 0.2 11.4 4.5 0.064 13.0 0.5 2.2 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.17 CRG92583.1 - 1 9.6 5.3 15 6.0 0.2 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 CRG92583.1 - 1.1 9.9 8.4 3.5 8.2 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG92583.1 - 2.7 8.7 13.1 4.1 8.1 0.2 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat APH PF01636.23 CRG92584.1 - 5.2e-11 42.9 0.0 1.1e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Cwf_Cwc_15 PF04889.12 CRG92584.1 - 0.29 10.9 3.4 0.41 10.3 3.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ChAPs PF09295.10 CRG92585.1 - 5.6e-153 509.6 0.0 7e-153 509.3 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 CRG92585.1 - 1.9e-07 31.3 2.8 0.23 12.4 0.1 4.6 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 CRG92585.1 - 8.6e-06 25.5 0.2 0.0038 17.2 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 CRG92585.1 - 6.1e-05 22.7 0.0 0.033 14.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 CRG92585.1 - 0.00015 22.2 0.1 0.99 10.0 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 CRG92585.1 - 0.00061 20.0 1.7 0.71 10.2 0.1 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 CRG92585.1 - 0.0014 18.7 0.2 0.11 12.7 0.0 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 CRG92585.1 - 0.013 14.7 0.4 0.19 10.9 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 CRG92585.1 - 0.042 13.9 0.5 1.1 9.5 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Zn_clus PF00172.18 CRG92587.1 - 7.1e-06 26.0 12.1 1.2e-05 25.3 12.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 CRG92587.1 - 7.1e-06 25.2 0.4 2.4e-05 23.5 0.4 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Herpes_capsid PF06112.11 CRG92587.1 - 1.1 9.3 0.0 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 Gammaherpesvirus capsid protein Epimerase PF01370.21 CRG92588.1 - 8.6e-18 64.7 0.0 1.1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 CRG92588.1 - 4.5e-13 49.3 0.0 8.7e-13 48.4 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 CRG92588.1 - 2e-10 40.1 0.0 2.6e-10 39.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 CRG92588.1 - 9.5e-06 24.9 0.0 2.5e-05 23.5 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 CRG92588.1 - 1.4e-05 24.5 0.1 0.1 11.8 0.1 2.6 2 1 0 2 2 2 2 Male sterility protein KR PF08659.10 CRG92588.1 - 0.0011 18.9 0.1 0.071 13.0 0.1 2.2 1 1 1 2 2 2 1 KR domain Ldh_1_N PF00056.23 CRG92588.1 - 0.011 15.8 0.1 0.018 15.1 0.1 1.4 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 CRG92588.1 - 0.016 14.4 0.0 0.061 12.4 0.0 1.9 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 CRG92588.1 - 0.019 14.8 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 CRG92588.1 - 0.058 12.9 0.0 0.14 11.6 0.0 1.7 1 1 0 1 1 1 0 short chain dehydrogenase SHNi-TPR PF10516.9 CRG92588.1 - 0.2 11.2 0.4 0.37 10.3 0.4 1.5 1 0 0 1 1 1 0 SHNi-TPR ERCC4 PF02732.15 CRG92589.1 - 1.4e-27 96.9 0.0 2.2e-27 96.2 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain Ish1 PF10281.9 CRG92589.1 - 0.05 13.9 0.3 0.33 11.3 0.0 2.6 3 0 0 3 3 3 0 Putative stress-responsive nuclear envelope protein E1-E2_ATPase PF00122.20 CRG92590.1 - 2.9e-52 176.8 0.1 2.1e-51 174.0 0.1 2.3 2 0 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 CRG92590.1 - 6.1e-51 170.7 11.1 7.6e-12 45.5 0.1 5.7 5 0 0 5 5 5 5 Heavy-metal-associated domain Hydrolase PF00702.26 CRG92590.1 - 6.8e-33 114.7 0.0 1.6e-32 113.5 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 CRG92590.1 - 9.4e-06 25.6 0.2 0.0013 18.5 0.1 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase SLS PF14611.6 CRG92590.1 - 0.1 12.4 0.0 15 5.3 0.0 2.5 1 1 1 2 2 2 0 Mitochondrial inner-membrane-bound regulator Importin_rep_3 PF18806.1 CRG92590.1 - 0.16 12.0 0.4 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 Importin 13 repeat Fer2_BFD PF04324.15 CRG92590.1 - 1.2 9.5 7.4 45 4.5 0.0 4.8 5 0 0 5 5 5 0 BFD-like [2Fe-2S] binding domain TFIIB PF00382.19 CRG92591.1 - 6.7e-35 119.0 1.0 3.8e-18 65.3 0.1 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 CRG92591.1 - 4e-23 81.7 8.9 5.3e-23 81.3 0.1 3.5 3 0 0 3 3 3 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 CRG92591.1 - 0.0053 16.5 0.1 1.5 8.6 0.0 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain DUF5301 PF17225.3 CRG92591.1 - 0.021 15.2 1.1 0.074 13.5 1.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) TF_Zn_Ribbon PF08271.12 CRG92591.1 - 0.18 11.3 1.4 0.38 10.3 1.4 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding adh_short PF00106.25 CRG92593.1 - 4.6e-34 117.6 0.1 6e-34 117.2 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92593.1 - 2.3e-25 89.5 0.0 2.8e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92593.1 - 0.00064 19.7 0.0 0.00091 19.2 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 CRG92594.1 - 2.1e-33 115.4 0.0 2.6e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92594.1 - 3.1e-23 82.6 0.0 3.9e-23 82.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92594.1 - 0.00074 19.5 0.0 0.0019 18.1 0.0 1.7 1 1 0 1 1 1 1 KR domain Asparaginase PF00710.20 CRG92594.1 - 0.11 12.0 0.0 0.34 10.4 0.0 1.8 2 0 0 2 2 2 0 Asparaginase, N-terminal EHN PF06441.12 CRG92595.1 - 6.6e-34 116.5 0.4 1.1e-33 115.8 0.4 1.4 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 CRG92595.1 - 5.7e-11 42.6 0.5 1.3e-10 41.4 0.2 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 CRG92595.1 - 0.0015 19.2 4.4 0.0041 17.8 4.4 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family NAD_binding_2 PF03446.15 CRG92596.1 - 5.3e-13 49.4 0.0 1.5e-12 47.9 0.0 1.7 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 CRG92596.1 - 3e-07 30.7 0.0 5.9e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Adeno_PIX PF03955.14 CRG92596.1 - 0.37 11.0 1.8 0.7 10.1 0.3 2.0 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) Fungal_trans_2 PF11951.8 CRG92597.1 - 3.5e-16 59.0 0.1 4.7e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92597.1 - 1.9e-07 31.1 14.3 1.9e-07 31.1 14.3 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Opy2 PF09463.10 CRG92597.1 - 3.5 8.0 9.7 0.19 12.1 3.5 2.2 2 0 0 2 2 2 0 Opy2 protein TPT PF03151.16 CRG92598.1 - 1.4e-23 83.7 26.3 1.8e-23 83.4 26.3 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 CRG92598.1 - 0.27 10.4 26.7 0.49 9.6 26.7 1.3 1 0 0 1 1 1 0 UAA transporter family Amino_oxidase PF01593.24 CRG92599.1 - 2.8e-08 33.5 0.0 3.9e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 CRG92599.1 - 2.9e-08 33.8 0.0 6.3e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 CRG92599.1 - 0.0047 16.2 0.0 0.021 14.1 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 CRG92599.1 - 0.008 15.5 0.1 0.016 14.5 0.1 1.5 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 CRG92599.1 - 0.0097 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 CRG92599.1 - 0.012 14.9 0.0 0.022 14.0 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FAD_oxidored PF12831.7 CRG92599.1 - 0.029 13.7 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase DAO PF01266.24 CRG92599.1 - 0.07 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase TrkA_N PF02254.18 CRG92599.1 - 0.11 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain HI0933_like PF03486.14 CRG92599.1 - 0.12 11.1 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 CRG92599.1 - 0.13 11.3 0.1 0.21 10.6 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pkinase PF00069.25 CRG92601.1 - 2.6e-66 223.7 0.0 3.8e-66 223.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92601.1 - 1.5e-31 109.7 0.0 1.8e-30 106.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 CRG92601.1 - 0.00016 21.1 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CRG92601.1 - 0.00048 19.8 0.1 0.024 14.3 0.0 2.3 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 CRG92601.1 - 0.0042 16.1 0.4 0.0066 15.4 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 CRG92601.1 - 0.0085 15.4 0.1 0.089 12.1 0.0 2.2 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 CRG92601.1 - 0.031 14.2 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Fungal_trans_2 PF11951.8 CRG92602.1 - 3e-21 75.7 9.4 2.1e-20 72.9 9.4 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 CRG92602.1 - 2.2e-06 27.7 8.5 5.5e-06 26.4 8.5 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 CRG92603.1 - 1.7e-64 218.3 0.0 2.1e-64 218.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BTB PF00651.31 CRG92604.1 - 0.11 12.7 0.0 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 BTB/POZ domain MFS_1 PF07690.16 CRG92605.1 - 1.4e-33 116.3 22.4 1.4e-33 116.3 22.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF3341 PF11821.8 CRG92605.1 - 0.56 9.8 7.4 0.062 13.0 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) Glyco_hydro_88 PF07470.13 CRG92606.1 - 6.6e-92 308.2 5.3 7.5e-92 308.0 5.3 1.0 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 CRG92606.1 - 0.003 16.1 0.7 0.0048 15.5 0.3 1.5 2 0 0 2 2 2 1 Beta-L-arabinofuranosidase, GH127 Cytochrom_B561 PF03188.16 CRG92607.1 - 2.9e-14 53.3 3.3 2.9e-14 53.3 3.3 2.3 2 1 1 3 3 3 1 Eukaryotic cytochrome b561 DUF4271 PF14093.6 CRG92607.1 - 0.11 12.4 5.5 0.15 11.9 5.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) DUF4079 PF13301.6 CRG92607.1 - 1.8 8.7 16.5 2.3 8.4 7.6 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF3693 PF12472.8 CRG92608.1 - 0.013 15.1 0.1 0.63 9.7 0.0 3.1 3 0 0 3 3 3 0 Phage related protein SIC PF03482.13 CRG92609.1 - 0.054 13.7 0.1 0.098 12.9 0.1 1.4 1 0 0 1 1 1 0 sic protein repeat bZIP_1 PF00170.21 CRG92610.1 - 1.5e-05 25.0 3.1 2.8e-05 24.1 3.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor EF-hand_14 PF17959.1 CRG92610.1 - 0.1 13.0 0.0 0.93 9.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain Lge1 PF11488.8 CRG92610.1 - 0.16 12.1 0.3 0.35 11.1 0.3 1.5 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 TPMT PF05724.11 CRG92611.1 - 2e-28 99.6 0.0 3.1e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 CRG92611.1 - 1.4e-05 25.7 0.0 2.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92611.1 - 6.1e-05 23.6 0.0 0.00011 22.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92611.1 - 0.0021 17.9 0.0 0.0039 17.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG92611.1 - 0.0046 16.8 0.0 0.0061 16.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 CRG92611.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB ABC2_membrane PF01061.24 CRG92612.1 - 6.9e-68 228.2 40.6 1e-46 159.0 18.5 2.7 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 CRG92612.1 - 1.2e-37 129.5 0.0 1.4e-18 67.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 CRG92612.1 - 3e-27 94.3 6.1 1.2e-23 82.7 0.0 3.3 3 0 0 3 3 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 CRG92612.1 - 1.6e-08 34.0 10.9 1.6e-08 34.0 10.9 2.1 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC_trans_N PF14510.6 CRG92612.1 - 2.1e-08 34.6 0.0 6.5e-08 33.1 0.0 1.9 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_25 PF13481.6 CRG92612.1 - 4e-06 26.5 0.0 0.0057 16.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 CRG92612.1 - 0.00011 22.2 0.4 0.0077 16.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 CRG92612.1 - 0.00014 22.3 0.2 0.057 13.8 0.1 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 CRG92612.1 - 0.00068 20.2 0.0 1.1 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 CRG92612.1 - 0.0015 18.3 0.9 0.074 12.8 0.2 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 CRG92612.1 - 0.0056 17.0 0.4 0.19 12.0 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 CRG92612.1 - 0.015 15.4 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 CRG92612.1 - 0.016 15.4 0.5 0.91 9.7 0.1 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 CRG92612.1 - 0.04 13.5 1.2 1.7 8.2 0.3 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 CRG92612.1 - 0.04 13.6 0.6 3.7 7.2 0.1 2.8 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 CRG92612.1 - 0.06 13.2 0.0 4.1 7.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 CRG92612.1 - 0.18 11.0 0.6 3.3 6.9 0.3 2.3 2 0 0 2 2 2 0 Zeta toxin tRNA-synt_2b PF00587.25 CRG92614.1 - 4.6e-18 65.8 0.0 2.4e-17 63.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 CRG92614.1 - 5.2e-08 33.1 5.4 8e-08 32.5 5.4 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain BAR PF03114.18 CRG92614.1 - 0.0067 16.1 1.1 0.012 15.3 1.1 1.3 1 0 0 1 1 1 1 BAR domain GAS PF13851.6 CRG92614.1 - 0.011 15.1 6.1 0.011 15.1 6.1 1.6 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Vps54_N PF10475.9 CRG92614.1 - 0.032 13.5 0.5 0.045 13.0 0.5 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex BLOC1_2 PF10046.9 CRG92614.1 - 0.098 13.0 1.7 0.82 10.0 0.1 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nup88 PF10168.9 CRG92614.1 - 0.11 10.3 1.1 0.18 9.5 1.1 1.3 1 0 0 1 1 1 0 Nuclear pore component Occludin_ELL PF07303.13 CRG92614.1 - 0.13 13.0 2.2 0.3 11.8 1.5 1.8 1 1 1 2 2 2 0 Occludin homology domain TMPIT PF07851.13 CRG92614.1 - 0.31 10.2 1.7 0.46 9.7 1.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 CRG92614.1 - 1.4 7.4 3.2 2.7 6.5 3.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Allantoicase PF03561.15 CRG92615.1 - 2.8e-87 290.0 0.0 5.4e-44 149.7 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat HATPase_c PF02518.26 CRG92616.1 - 7.4e-30 103.7 0.0 1.7e-29 102.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG92616.1 - 3.3e-21 75.6 0.0 7.5e-21 74.4 0.0 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CRG92616.1 - 1.7e-18 66.4 0.0 9.2e-18 64.0 0.0 2.4 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 CRG92616.1 - 1.3e-12 48.2 0.0 3.4e-12 46.8 0.0 1.8 1 0 0 1 1 1 1 GAF domain AAA_16 PF13191.6 CRG92616.1 - 3.3e-12 47.1 0.0 4e-11 43.6 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain GAF PF01590.26 CRG92616.1 - 2.3e-07 31.5 0.0 5.9e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 GAF domain NB-ARC PF00931.22 CRG92616.1 - 4e-07 29.5 0.2 0.0064 15.7 0.1 3.0 3 0 0 3 3 3 2 NB-ARC domain GAF_3 PF13492.6 CRG92616.1 - 3.1e-06 27.6 0.0 6.9e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 GAF domain Pkinase PF00069.25 CRG92616.1 - 8.4e-06 25.3 0.0 4.4e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain TPR_2 PF07719.17 CRG92616.1 - 0.00033 20.5 0.4 2.5 8.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat HATPase_c_3 PF13589.6 CRG92616.1 - 0.005 16.7 0.0 0.013 15.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NACHT PF05729.12 CRG92616.1 - 0.0061 16.5 0.2 0.14 12.1 0.2 2.6 1 1 0 1 1 1 1 NACHT domain TPR_1 PF00515.28 CRG92616.1 - 0.035 13.9 1.6 2.9 7.9 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat MeaB PF03308.16 CRG92616.1 - 0.066 12.2 0.0 0.13 11.2 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TPR_8 PF13181.6 CRG92616.1 - 0.087 13.1 0.7 13 6.3 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1347 PF07079.11 CRG92616.1 - 0.1 11.2 0.1 0.17 10.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1347) ATPase_2 PF01637.18 CRG92616.1 - 0.13 12.2 0.1 0.73 9.7 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 CRG92616.1 - 0.15 12.4 0.0 2.4 8.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain TPR_12 PF13424.6 CRG92616.1 - 0.16 12.2 7.8 0.23 11.8 0.1 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 CRG92616.1 - 1.2 9.1 4.3 3 7.9 0.2 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 CRG92616.1 - 1.6 9.7 8.0 9.2 7.4 0.1 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 CRG92616.1 - 2.6 8.8 0.0 2.6 8.8 0.0 3.3 4 0 0 4 4 2 0 Tetratricopeptide repeat HATPase_c PF02518.26 CRG92617.1 - 2e-22 79.8 0.6 1.2e-21 77.3 0.1 2.6 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 CRG92617.1 - 8.8e-22 77.4 0.1 2.1e-21 76.2 0.1 1.7 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 CRG92617.1 - 8e-17 61.0 0.1 2.1e-16 59.7 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 CRG92617.1 - 4.3e-11 43.0 0.2 0.00048 20.4 0.1 3.8 3 0 0 3 3 3 3 PAS fold PAS_4 PF08448.10 CRG92617.1 - 1e-06 28.9 0.1 6.6e-06 26.4 0.0 2.5 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 CRG92617.1 - 4e-05 23.8 0.1 2.4 8.5 0.0 4.1 3 1 0 3 3 3 2 PAS domain PAS PF00989.25 CRG92617.1 - 0.0014 18.6 0.0 3.1 7.8 0.0 2.9 2 0 0 2 2 2 2 PAS fold KxDL PF10241.9 CRG92618.1 - 1.2e-31 108.9 0.1 1.5e-31 108.5 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein Cir_N PF10197.9 CRG92619.1 - 1.8e-06 28.0 6.4 1.8e-06 28.0 6.4 4.2 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR Methyltransf_25 PF13649.6 CRG92620.1 - 7.3e-11 42.6 0.0 2.7e-10 40.8 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain PrmA PF06325.13 CRG92620.1 - 3.2e-10 39.9 0.0 5.8e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 CRG92620.1 - 6.5e-09 36.3 0.0 2.7e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92620.1 - 2.3e-08 34.0 0.0 4.2e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 CRG92620.1 - 3.5e-06 27.0 0.0 6.6e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG92620.1 - 4.1e-06 26.7 0.0 4.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 CRG92620.1 - 1.3e-05 24.9 0.1 2.5e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 CRG92620.1 - 0.00074 18.9 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_9 PF08003.11 CRG92620.1 - 0.0011 18.0 0.1 0.0022 17.0 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_2 PF00891.18 CRG92620.1 - 0.0044 16.3 0.0 0.0077 15.5 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Met_10 PF02475.16 CRG92620.1 - 0.0055 16.5 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Mito_fiss_reg PF05308.11 CRG92620.1 - 0.012 15.8 0.3 0.02 15.0 0.3 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator PCMT PF01135.19 CRG92620.1 - 0.014 15.1 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 CRG92620.1 - 0.018 16.0 0.0 0.084 13.9 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 CRG92620.1 - 0.021 14.1 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 CRG92620.1 - 0.023 15.4 0.0 0.054 14.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.18 CRG92620.1 - 0.023 14.4 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 TehB PF03848.14 CRG92620.1 - 0.043 13.2 0.0 0.076 12.4 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TehB PRMT5 PF05185.16 CRG92620.1 - 0.061 13.2 0.1 0.32 10.8 0.1 2.0 1 1 0 1 1 1 0 PRMT5 arginine-N-methyltransferase DUF974 PF06159.13 CRG92620.1 - 0.063 13.1 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF974) Methyltransf_16 PF10294.9 CRG92620.1 - 0.069 12.9 0.0 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase CLZ PF16526.5 CRG92620.1 - 0.3 11.4 2.2 0.56 10.6 2.2 1.4 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Mo25 PF08569.11 CRG92621.1 - 1.1e-125 419.3 0.0 1.3e-125 419.2 0.0 1.0 1 0 0 1 1 1 1 Mo25-like RepA_N PF06970.11 CRG92621.1 - 0.037 14.0 0.1 0.072 13.0 0.1 1.5 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus RabGAP-TBC PF00566.18 CRG92622.1 - 2e-33 115.9 0.0 3.1e-33 115.2 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DPCD PF14913.6 CRG92622.1 - 0.055 12.8 0.6 0.16 11.3 0.6 1.8 1 0 0 1 1 1 0 DPCD protein family p450 PF00067.22 CRG92623.1 - 3.2e-83 280.0 0.0 3.8e-83 279.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ELO PF01151.18 CRG92624.1 - 6.9e-60 202.7 16.1 8.4e-60 202.4 16.1 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family 4HBT_2 PF13279.6 CRG92625.1 - 4e-09 37.0 0.0 6.8e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily BAR_2 PF10455.9 CRG92625.1 - 0.027 13.6 0.1 0.042 13.0 0.1 1.2 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking WBS_methylT PF12589.8 CRG92625.1 - 0.18 12.6 3.9 0.35 11.6 3.9 1.4 1 0 0 1 1 1 0 Methyltransferase involved in Williams-Beuren syndrome MFS_1 PF07690.16 CRG92626.1 - 1.9e-38 132.3 62.4 9.5e-38 130.0 54.9 3.1 2 1 0 2 2 2 2 Major Facilitator Superfamily Meckelin PF09773.9 CRG92626.1 - 1.6 6.7 3.0 2.3 6.2 3.0 1.1 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) DUF2722 PF10846.8 CRG92628.1 - 7.4e-08 31.8 0.4 7.4e-08 31.8 0.4 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF2722) DIL PF01843.19 CRG92629.1 - 2.3e-30 104.9 1.3 5.3e-30 103.8 1.3 1.6 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 CRG92629.1 - 2.1e-14 53.9 0.1 1.1e-13 51.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 CRG92629.1 - 6.5e-10 39.1 0.0 6.8e-05 23.1 0.0 3.5 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 CRG92629.1 - 3e-08 33.7 0.0 0.0086 16.5 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 CRG92629.1 - 3.1e-08 34.0 0.0 6.8e-05 23.3 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG92629.1 - 5.3e-07 29.5 0.2 0.0047 17.3 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat RasGEF PF00617.19 CRG92630.1 - 2.3e-43 148.4 0.3 5e-43 147.4 0.1 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 CRG92630.1 - 8.8e-12 45.2 0.3 2.6e-11 43.7 0.3 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif ADH_N_2 PF16884.5 CRG92631.1 - 1.5e-23 82.8 0.0 2.6e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 CRG92631.1 - 2.8e-20 72.6 0.8 4.6e-20 71.9 0.8 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 CRG92631.1 - 1.2e-05 26.4 0.1 2.9e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Fungal_trans PF04082.18 CRG92632.1 - 5e-19 68.4 3.2 7.5e-19 67.8 3.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_M13_N PF05649.13 CRG92633.1 - 1.8e-86 291.3 0.0 2.5e-86 290.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 CRG92633.1 - 1.5e-59 201.1 0.0 3.1e-59 200.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M13 MFS_1 PF07690.16 CRG92633.1 - 7.4e-29 100.8 53.3 3.6e-28 98.5 53.3 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Fungal_trans_2 PF11951.8 CRG92633.1 - 2.4e-11 43.1 0.2 4.7e-11 42.1 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain bZIP_1 PF00170.21 CRG92634.1 - 1.7e-07 31.2 11.6 1.4e-06 28.3 11.6 2.1 1 1 0 1 1 1 1 bZIP transcription factor DUF4618 PF15397.6 CRG92634.1 - 0.00011 21.7 2.3 0.00016 21.2 2.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) bZIP_2 PF07716.15 CRG92634.1 - 0.00032 20.7 11.8 0.0064 16.5 7.7 2.2 1 1 1 2 2 2 1 Basic region leucine zipper SlyX PF04102.12 CRG92634.1 - 0.00059 20.4 2.7 0.00059 20.4 2.7 1.9 1 1 1 2 2 2 1 SlyX SHE3 PF17078.5 CRG92634.1 - 0.0016 18.2 3.4 0.002 17.9 3.4 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 CRG92634.1 - 0.002 18.6 7.0 0.0032 17.9 7.0 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor TMF_DNA_bd PF12329.8 CRG92634.1 - 0.041 13.9 2.0 0.088 12.8 1.9 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF3573 PF12097.8 CRG92634.1 - 0.045 12.6 0.1 0.055 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Tho2 PF11262.8 CRG92634.1 - 0.069 12.3 1.8 0.083 12.1 1.8 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 UPF0242 PF06785.11 CRG92634.1 - 0.072 13.2 2.7 0.098 12.8 2.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ADIP PF11559.8 CRG92634.1 - 0.084 13.0 7.2 0.12 12.5 7.2 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 CRG92634.1 - 0.093 13.0 8.0 0.15 12.3 8.0 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Tyr-DNA_phospho PF06087.12 CRG92634.1 - 0.097 11.5 0.3 0.13 11.1 0.3 1.1 1 0 0 1 1 1 0 Tyrosyl-DNA phosphodiesterase M PF02370.16 CRG92634.1 - 0.13 12.9 3.7 0.16 12.6 0.7 2.4 2 0 0 2 2 2 0 M protein repeat DUF4200 PF13863.6 CRG92634.1 - 0.17 12.3 10.0 0.28 11.6 3.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) MPS2 PF17060.5 CRG92634.1 - 0.24 10.6 2.9 0.29 10.4 2.9 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 FUSC PF04632.12 CRG92634.1 - 0.34 9.4 4.0 0.38 9.2 4.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Vac_Fusion PF02346.16 CRG92634.1 - 0.65 9.7 7.4 0.2 11.3 4.3 1.8 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 ABC_tran_CTD PF16326.5 CRG92634.1 - 0.7 10.2 5.9 6.3 7.1 6.0 2.2 1 1 0 1 1 1 0 ABC transporter C-terminal domain Swi5 PF07061.11 CRG92634.1 - 1.1 9.4 5.2 2 8.5 5.2 1.5 1 0 0 1 1 1 0 Swi5 Casc1_N PF15927.5 CRG92634.1 - 1.1 8.9 8.9 1.5 8.4 8.9 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus p450 PF00067.22 CRG92635.1 - 2.5e-33 115.5 0.0 7.4e-25 87.6 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 p450 PF00067.22 CRG92636.1 - 1.1e-25 90.3 0.0 1.5e-25 89.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Trypsin PF00089.26 CRG92636.1 - 0.053 13.3 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Trypsin p450 PF00067.22 CRG92637.1 - 1.9e-52 178.6 0.0 2.8e-52 178.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 G-alpha PF00503.20 CRG92638.1 - 1.4e-108 363.2 1.3 2.3e-108 362.5 0.4 1.7 2 0 0 2 2 2 1 G-protein alpha subunit Arf PF00025.21 CRG92638.1 - 7.3e-12 45.1 0.1 1.3e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF1713 PF08213.11 CRG92638.1 - 7.8e-11 41.7 19.2 2.1e-10 40.4 19.2 1.8 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Gtr1_RagA PF04670.12 CRG92638.1 - 4.8e-06 26.1 0.1 0.0041 16.5 0.0 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Pet20 PF08692.10 CRG92638.1 - 0.014 16.1 0.0 0.044 14.5 0.0 1.8 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Roc PF08477.13 CRG92638.1 - 0.072 13.3 0.3 3.2 8.0 0.1 2.8 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 CRG92638.1 - 0.1 12.7 0.0 13 5.9 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 CRG92638.1 - 0.16 11.7 0.1 0.37 10.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP-synt_C PF00137.21 CRG92639.1 - 2.8e-35 120.5 33.6 2.9e-21 75.6 15.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C GerA PF03323.13 CRG92639.1 - 1.4 7.3 3.7 10 4.5 0.3 2.3 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Podoplanin PF05808.11 CRG92640.1 - 0.0031 17.6 2.5 0.0052 16.9 2.5 1.3 1 0 0 1 1 1 1 Podoplanin Mid2 PF04478.12 CRG92640.1 - 0.0087 15.9 0.3 0.014 15.3 0.3 1.3 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor SKG6 PF08693.10 CRG92640.1 - 0.015 14.7 0.2 0.029 13.8 0.2 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain VSP PF03302.13 CRG92640.1 - 0.093 11.6 3.4 0.17 10.7 3.4 1.5 1 1 0 1 1 1 0 Giardia variant-specific surface protein DNA_pol_B PF00136.21 CRG92640.1 - 0.11 11.2 0.1 0.13 10.9 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase family B DUF5305 PF17231.2 CRG92640.1 - 0.17 11.3 0.2 0.26 10.7 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) TNFR_16_TM PF18422.1 CRG92640.1 - 0.17 11.9 0.2 0.31 11.0 0.2 1.3 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain VPDSG-CTERM PF18205.1 CRG92640.1 - 0.21 11.4 3.1 0.53 10.1 3.1 1.7 1 0 0 1 1 1 0 VPDSG-CTERM motif Mucin PF01456.17 CRG92640.1 - 0.53 10.3 14.1 0.33 10.9 11.6 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein PhoLip_ATPase_C PF16212.5 CRG92642.1 - 7.7e-66 222.4 18.2 7.7e-66 222.4 18.2 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 CRG92642.1 - 4.7e-20 71.0 6.0 3.7e-18 65.0 0.1 2.5 2 0 0 2 2 2 2 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 CRG92642.1 - 2.3e-12 46.8 0.0 2.8e-11 43.4 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 CRG92642.1 - 5e-12 46.6 0.0 2.2e-05 24.9 0.0 3.6 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 CRG92642.1 - 8.5e-08 31.9 0.2 3.7e-07 29.8 0.0 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 CRG92642.1 - 0.00047 20.0 0.0 0.0012 18.6 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pmp3 PF01679.17 CRG92643.1 - 1.4e-20 73.2 6.7 1.4e-20 73.2 6.7 2.2 2 0 0 2 2 2 1 Proteolipid membrane potential modulator CFEM PF05730.11 CRG92643.1 - 0.00048 20.2 9.6 0.00081 19.4 9.6 1.4 1 0 0 1 1 1 1 CFEM domain PD40 PF07676.12 CRG92644.1 - 1.1e-16 60.2 1.6 8.2e-09 35.2 0.3 4.7 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Peptidase_S9 PF00326.21 CRG92644.1 - 1.8e-07 30.9 0.0 1.8e-05 24.3 0.0 3.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family DPPIV_N PF00930.21 CRG92644.1 - 8.4e-06 24.8 0.7 0.0039 16.0 0.1 3.4 1 1 1 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region ANAPC4_WD40 PF12894.7 CRG92644.1 - 0.007 16.6 0.1 2.7 8.3 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 CRG92644.1 - 0.039 12.0 0.1 0.054 11.5 0.1 1.1 1 0 0 1 1 1 0 IKI3 family Abhydrolase_3 PF07859.13 CRG92644.1 - 0.06 13.2 0.3 0.22 11.3 0.6 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Hydrolase_6 PF13344.6 CRG92646.1 - 2.1e-23 82.3 0.0 4e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 CRG92646.1 - 1.7e-11 44.0 0.0 1.2e-10 41.3 0.0 2.5 2 1 0 2 2 2 1 HAD-hyrolase-like Lipase_3 PF01764.25 CRG92646.1 - 0.028 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF676 PF05057.14 CRG92647.1 - 1.9e-50 171.4 0.0 3.2e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 CRG92647.1 - 6e-06 27.0 0.1 8.7e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 CRG92647.1 - 0.00013 21.9 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 CRG92647.1 - 0.0031 17.2 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 PGAP1-like protein Lipase_3 PF01764.25 CRG92647.1 - 0.0037 17.1 0.0 0.0068 16.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 CRG92647.1 - 0.01 15.2 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Lipase_2 PF01674.18 CRG92647.1 - 0.066 12.7 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 2) LCAT PF02450.15 CRG92647.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ribosomal_L22e PF01776.17 CRG92649.1 - 6e-48 161.7 0.3 7.6e-48 161.4 0.3 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Translin PF01997.16 CRG92650.1 - 1.5e-47 162.3 0.0 1.9e-47 161.9 0.0 1.1 1 0 0 1 1 1 1 Translin family GMP_synt_C PF00958.22 CRG92650.1 - 0.12 12.5 0.0 0.6 10.2 0.0 2.0 2 0 0 2 2 2 0 GMP synthase C terminal domain GSHPx PF00255.19 CRG92651.1 - 5.4e-39 132.1 0.0 7.6e-39 131.6 0.0 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 CRG92651.1 - 0.027 14.4 0.0 0.05 13.5 0.0 1.5 1 1 0 1 1 1 0 AhpC/TSA family Pcc1 PF09341.10 CRG92652.1 - 4.3e-30 103.7 0.6 5.7e-30 103.3 0.6 1.2 1 0 0 1 1 1 1 Transcription factor Pcc1 Baculo_PEP_C PF04513.12 CRG92653.1 - 0.025 14.6 5.3 0.04 14.0 1.1 2.4 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF677 PF05055.12 CRG92653.1 - 0.55 9.1 1.4 0.78 8.6 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF677) DSPn PF14671.6 CRG92654.1 - 1.1e-40 139.4 0.0 5.2e-39 133.9 0.0 2.5 2 1 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 CRG92654.1 - 1.2e-15 57.5 0.1 3.5e-15 56.0 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 CRG92654.1 - 1.2e-05 25.0 0.0 2.1e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 CRG92654.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family MFS_1 PF07690.16 CRG92655.1 - 1.1e-29 103.5 35.5 1.6e-29 103.0 35.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 CRG92655.1 - 4.1e-09 35.8 9.0 4.1e-09 35.8 9.0 2.4 3 0 0 3 3 3 1 Sugar (and other) transporter Popeye PF04831.13 CRG92655.1 - 0.39 10.9 2.7 1.6 8.9 2.7 2.0 1 0 0 1 1 1 0 Popeye protein conserved region Peptidase_S10 PF00450.22 CRG92656.1 - 6.4e-80 269.6 0.1 8.7e-80 269.2 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Glyco_hydro_31 PF01055.26 CRG92657.1 - 4.2e-143 477.7 7.1 5.3e-143 477.4 7.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 CRG92657.1 - 1.7e-37 128.1 0.1 3.3e-37 127.2 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 CRG92657.1 - 2.4e-09 37.4 0.1 1e-08 35.3 0.1 2.2 1 0 0 1 1 1 1 Galactose mutarotase-like FA_hydroxylase PF04116.13 CRG92659.1 - 3.7e-18 66.1 12.5 3.7e-18 66.1 12.5 2.2 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily TssN PF17555.2 CRG92659.1 - 2.7 7.3 7.7 0.31 10.4 0.9 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssN DUF3112 PF11309.8 CRG92660.1 - 3e-12 46.5 11.5 1e-07 31.6 0.3 2.6 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) Tmemb_9 PF05434.11 CRG92660.1 - 0.15 12.0 0.6 0.71 9.8 0.0 2.1 2 0 0 2 2 2 0 TMEM9 DUF2177 PF09945.9 CRG92660.1 - 0.41 10.7 7.6 1.3 9.1 0.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2177) MFS_1 PF07690.16 CRG92661.1 - 4e-34 118.1 30.1 4e-34 118.1 30.1 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG92661.1 - 1.2e-09 37.2 8.6 9.1e-08 31.0 3.6 2.2 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG92661.1 - 1.2e-08 34.3 9.9 1.2e-08 34.3 9.9 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter Peptidase_M48_N PF16491.5 CRG92661.1 - 0.12 12.2 4.0 4.6 7.1 0.7 3.2 3 0 0 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices Menin PF05053.13 CRG92662.1 - 4.1 5.6 5.4 6.7 4.9 5.4 1.2 1 0 0 1 1 1 0 Menin Glyco_hydro_18 PF00704.28 CRG92663.1 - 2.7e-24 86.5 2.1 7.2e-24 85.1 2.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_C39_2 PF13529.6 CRG92663.1 - 0.027 15.0 0.1 0.055 14.0 0.1 1.4 1 0 0 1 1 1 0 Peptidase_C39 like family TPR_19 PF14559.6 CRG92663.1 - 0.08 13.5 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 CRG92664.1 - 3.1e-19 69.4 0.0 5.2e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92664.1 - 5.6e-13 48.8 0.0 9.4e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3432 PF11914.8 CRG92664.1 - 1.4 9.2 4.7 0.98 9.7 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3432) CorA PF01544.18 CRG92665.1 - 0.73 9.1 11.3 3 7.1 11.2 2.2 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein ADH_zinc_N PF00107.26 CRG92666.1 - 4.3e-09 36.4 0.0 1.6e-08 34.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 CRG92666.1 - 3.9e-07 29.9 0.0 7.3e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Gly_transf_sug PF04488.15 CRG92667.1 - 3.7e-13 49.9 0.1 7.3e-13 49.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TcdA_TcdB PF12919.7 CRG92667.1 - 0.036 13.4 0.0 0.057 12.7 0.0 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain MFS_1 PF07690.16 CRG92669.1 - 5.4e-30 104.5 28.5 5.4e-30 104.5 28.5 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 CRG92669.1 - 4.7e-05 22.9 3.8 4.7e-05 22.9 3.8 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB PTR2 PF00854.21 CRG92670.1 - 4.3e-52 177.3 5.8 6.2e-52 176.7 5.8 1.2 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 CRG92670.1 - 8.9e-11 41.3 21.9 3.1e-06 26.4 10.3 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Phage_holin_3_6 PF07332.11 CRG92670.1 - 0.078 13.0 0.3 0.078 13.0 0.3 3.2 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Glyco_hydro_28 PF00295.17 CRG92671.1 - 7.6e-48 163.2 9.7 1.1e-47 162.7 9.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 ketoacyl-synt PF00109.26 CRG92673.1 - 6.5e-63 212.7 0.1 1.4e-62 211.5 0.1 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG92673.1 - 9.2e-57 191.8 0.7 3.9e-56 189.8 0.1 2.4 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 CRG92673.1 - 5.2e-56 190.1 0.0 8.5e-56 189.4 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG92673.1 - 5.9e-50 170.6 0.0 1.3e-49 169.5 0.0 1.6 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG92673.1 - 4.9e-37 126.5 0.0 2.1e-36 124.5 0.0 2.2 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 CRG92673.1 - 3e-19 70.4 0.0 1.1e-17 65.3 0.0 2.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 CRG92673.1 - 4.1e-17 62.4 0.0 6e-16 58.6 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG92673.1 - 2.9e-14 53.0 0.1 4.7e-13 49.0 0.0 2.7 2 0 0 2 2 2 1 short chain dehydrogenase KAsynt_C_assoc PF16197.5 CRG92673.1 - 8.7e-12 45.5 0.0 3.9e-11 43.4 0.0 2.2 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension adh_short_C2 PF13561.6 CRG92673.1 - 3.9e-08 33.2 0.0 1.5e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase ADH_N PF08240.12 CRG92673.1 - 2.6e-07 30.5 0.6 5.6e-07 29.4 0.6 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PP-binding PF00550.25 CRG92673.1 - 9.3e-05 22.7 0.0 0.00035 20.9 0.0 2.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site Thiolase_N PF00108.23 CRG92673.1 - 0.00055 19.4 0.1 0.0013 18.1 0.1 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain 3Beta_HSD PF01073.19 CRG92673.1 - 0.00079 18.5 0.0 0.0016 17.5 0.0 1.5 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TMEM191C PF15194.6 CRG92673.1 - 0.098 12.9 1.1 5.3 7.2 0.0 3.7 3 0 0 3 3 3 0 TMEM191C family ThiF PF00899.21 CRG92673.1 - 0.13 11.6 0.3 0.3 10.4 0.3 1.5 1 0 0 1 1 1 0 ThiF family Thioesterase PF00975.20 CRG92674.1 - 8.8e-25 88.2 0.0 3.9e-24 86.1 0.0 1.9 1 1 0 1 1 1 1 Thioesterase domain PP-binding PF00550.25 CRG92674.1 - 5e-08 33.2 0.0 1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 Phosphopantetheine attachment site Abhydrolase_6 PF12697.7 CRG92674.1 - 0.00016 22.4 0.0 0.00021 22.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 CRG92674.1 - 0.00081 19.0 0.0 0.0012 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 CRG92674.1 - 0.029 14.0 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG92674.1 - 0.03 13.6 0.0 0.046 13.0 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 CRG92674.1 - 0.049 13.4 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase family ketoacyl-synt PF00109.26 CRG92675.1 - 2.2e-72 243.7 0.0 2.2e-72 243.7 0.0 2.0 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain GMC_oxred_N PF00732.19 CRG92675.1 - 2e-56 191.5 0.1 4.2e-56 190.5 0.0 1.6 2 0 0 2 2 2 1 GMC oxidoreductase SAT PF16073.5 CRG92675.1 - 1.7e-49 168.7 0.9 1.2e-48 165.9 0.0 2.5 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 CRG92675.1 - 1.3e-40 139.8 0.1 2.3e-40 139.1 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG92675.1 - 2.4e-35 121.1 0.5 6.6e-35 119.7 0.5 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain GMC_oxred_C PF05199.13 CRG92675.1 - 2.7e-29 102.6 0.0 7.1e-29 101.2 0.0 1.8 1 0 0 1 1 1 1 GMC oxidoreductase Thioesterase PF00975.20 CRG92675.1 - 1.2e-15 58.3 0.0 2.9e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Thioesterase domain PS-DH PF14765.6 CRG92675.1 - 5.9e-15 55.3 0.0 1.2e-14 54.3 0.0 1.5 1 0 0 1 1 1 1 Polyketide synthase dehydratase PP-binding PF00550.25 CRG92675.1 - 2.6e-12 46.9 0.1 7.2e-12 45.5 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 CRG92675.1 - 1.6e-06 28.5 0.0 6.8e-06 26.5 0.0 2.1 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Lycopene_cycl PF05834.12 CRG92675.1 - 0.0016 17.6 0.0 0.0026 16.9 0.0 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_2 PF00890.24 CRG92675.1 - 0.0027 16.8 0.1 0.78 8.7 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 CRG92675.1 - 0.003 17.8 0.2 0.01 16.0 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 CRG92675.1 - 0.03 13.9 1.3 0.25 10.9 1.3 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG92675.1 - 0.041 13.1 0.1 0.12 11.6 0.1 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thiolase_N PF00108.23 CRG92675.1 - 0.089 12.1 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 Thiolase, N-terminal domain Trp_halogenase PF04820.14 CRG92675.1 - 0.1 11.5 0.0 0.18 10.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_3 PF01494.19 CRG92676.1 - 8.5e-22 77.9 0.5 3.6e-21 75.8 0.5 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 CRG92676.1 - 7.3e-08 32.0 1.0 0.00015 21.1 0.5 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 CRG92676.1 - 5.8e-07 29.4 5.2 0.00024 20.8 2.7 2.5 1 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 CRG92676.1 - 8.2e-07 29.2 0.6 2.3e-06 27.7 0.6 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 CRG92676.1 - 2.8e-05 23.4 1.3 4.6e-05 22.7 1.3 1.3 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 CRG92676.1 - 3.3e-05 23.4 0.2 0.026 13.8 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 CRG92676.1 - 0.00012 21.0 0.9 0.00049 18.9 0.5 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox PF00070.27 CRG92676.1 - 0.00028 21.4 2.0 0.041 14.4 0.6 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 CRG92676.1 - 0.00076 18.7 0.3 0.0013 17.9 0.3 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A ApbA PF02558.16 CRG92676.1 - 0.0016 18.1 0.6 0.0039 16.8 0.6 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 CRG92676.1 - 0.0024 17.2 1.0 0.0073 15.6 0.6 2.2 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 CRG92676.1 - 0.011 15.0 0.4 0.021 14.0 0.4 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 CRG92676.1 - 0.012 14.9 0.3 0.023 14.0 0.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 CRG92676.1 - 0.014 14.7 0.6 0.024 14.0 0.6 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 CRG92676.1 - 0.023 13.8 3.0 0.054 12.5 0.9 2.2 2 1 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 CRG92676.1 - 0.048 12.5 0.9 0.11 11.4 0.2 1.8 2 0 0 2 2 2 0 Tryptophan halogenase DUF4090 PF13319.6 CRG92676.1 - 0.058 13.6 0.1 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4090) 3HCDH_N PF02737.18 CRG92676.1 - 0.088 12.7 0.7 0.18 11.7 0.3 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MCRA PF06100.11 CRG92676.1 - 0.096 11.5 0.6 0.52 9.0 0.1 1.9 2 0 0 2 2 2 0 MCRA family 2Fe-2S_Ferredox PF11591.8 CRG92676.1 - 0.25 11.2 2.2 19 5.2 0.3 2.9 2 0 0 2 2 2 0 Ferredoxin chloroplastic transit peptide Questin_oxidase PF14027.6 CRG92677.1 - 6e-66 223.3 0.1 7.1e-66 223.1 0.1 1.1 1 0 0 1 1 1 1 Questin oxidase-like Transketolase_N PF00456.21 CRG92678.1 - 3.9e-16 58.9 0.8 7.3e-15 54.7 0.8 2.1 1 1 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 CRG92678.1 - 6.9e-15 55.0 0.0 3.6e-14 52.7 0.0 2.2 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 CRG92678.1 - 2.5e-05 24.0 0.6 0.00013 21.7 0.1 2.3 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain TPP_enzyme_C PF02775.21 CRG92678.1 - 2.5e-05 24.1 2.0 0.00013 21.8 2.0 2.1 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain E1_dh PF00676.20 CRG92678.1 - 6.2e-05 22.1 0.2 0.00014 20.9 0.2 1.5 1 0 0 1 1 1 1 Dehydrogenase E1 component Peptidase_S9 PF00326.21 CRG92679.1 - 0.026 14.0 0.3 0.085 12.3 0.3 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 CRG92679.1 - 0.03 13.9 0.0 0.069 12.8 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold Aa_trans PF01490.18 CRG92680.1 - 1e-25 90.4 33.0 2.6e-25 89.0 33.0 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Glyco_hydro_43 PF04616.14 CRG92681.1 - 1.3e-31 110.0 0.1 1.7e-31 109.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 Fungal_trans_2 PF11951.8 CRG92682.1 - 5.9e-11 41.8 1.8 1.1e-10 41.0 1.8 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF4045 PF13254.6 CRG92682.1 - 0.27 10.8 4.5 0.48 10.0 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Glyco_hydro_18 PF00704.28 CRG92683.1 - 1.5e-16 61.0 0.0 3.4e-16 59.9 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 Lac_bphage_repr PF06543.12 CRG92683.1 - 1.8 8.6 3.6 36 4.4 0.4 3.0 3 0 0 3 3 3 0 Lactococcus bacteriophage repressor ApoL PF05461.11 CRG92683.1 - 1.8 7.8 3.3 3.4 6.9 3.3 1.3 1 0 0 1 1 1 0 Apolipoprotein L Pyr_redox_2 PF07992.14 CRG92684.1 - 1.3e-17 64.0 0.1 1.6e-08 34.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 CRG92684.1 - 6.5e-06 25.6 0.1 0.054 12.7 0.0 3.6 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 CRG92684.1 - 9.3e-05 21.7 0.2 0.0042 16.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 CRG92684.1 - 0.00076 19.5 0.6 0.24 11.4 0.2 2.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 CRG92684.1 - 0.0033 17.1 0.4 0.0044 16.7 0.4 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 CRG92684.1 - 0.0034 16.7 0.1 0.0067 15.7 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 CRG92684.1 - 0.006 15.3 0.1 0.21 10.3 0.1 2.2 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 CRG92684.1 - 0.035 13.2 0.1 0.077 12.0 0.0 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 CRG92684.1 - 0.037 13.3 0.1 0.062 12.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family NAD_binding_8 PF13450.6 CRG92684.1 - 0.069 13.4 1.9 0.071 13.4 0.3 1.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 CRG92684.1 - 0.074 12.2 0.0 11 5.0 0.1 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Peptidase_M28 PF04389.17 CRG92685.1 - 2e-38 132.1 0.0 2.9e-38 131.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 CRG92685.1 - 5.3e-10 39.2 0.0 1.3e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 CRG92685.1 - 0.0041 16.8 0.0 0.009 15.7 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 CRG92685.1 - 0.073 12.1 0.0 0.63 9.0 0.0 2.3 3 0 0 3 3 3 0 M42 glutamyl aminopeptidase ADH_zinc_N PF00107.26 CRG92686.1 - 0.023 14.7 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Lipoxygenase PF00305.19 CRG92687.1 - 1.7e-18 66.4 0.0 2.6e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Lipoxygenase Lipase_3 PF01764.25 CRG92688.1 - 2e-31 108.8 0.0 3.4e-31 108.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Carb_anhydrase PF00194.21 CRG92688.1 - 1.8e-30 106.4 0.0 4.1e-30 105.2 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase Lipase3_N PF03893.16 CRG92688.1 - 1.9e-13 50.2 0.4 4.6e-13 49.0 0.4 1.7 1 0 0 1 1 1 1 Lipase 3 N-terminal region Hydrolase_4 PF12146.8 CRG92688.1 - 2.6e-05 23.6 0.0 4.1e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CRG92688.1 - 0.00044 20.5 0.0 0.00078 19.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CRG92688.1 - 0.0026 18.4 0.2 0.0085 16.7 0.1 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Cutinase PF01083.22 CRG92688.1 - 0.067 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Cutinase PGAP1 PF07819.13 CRG92688.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_8 PF06259.12 CRG92688.1 - 0.13 11.9 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Pkinase PF00069.25 CRG92690.1 - 5.3e-10 39.1 0.2 7.3e-10 38.6 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92690.1 - 5.4e-07 29.1 0.2 8.1e-07 28.6 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 CRG92691.1 - 3.2e-33 113.2 3.4 4.7e-10 39.9 0.0 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG92691.1 - 2.2e-09 37.5 0.0 0.029 14.7 0.0 3.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 CRG92691.1 - 5e-09 36.3 0.1 9.1e-09 35.4 0.1 1.3 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG92691.1 - 2.7e-08 34.4 0.0 3.4e-06 27.6 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain zf-CCHC PF00098.23 CRG92691.1 - 2.8e-06 27.1 4.0 2.8e-06 27.1 4.0 1.9 2 0 0 2 2 1 1 Zinc knuckle WD40_like PF17005.5 CRG92691.1 - 0.0025 17.2 0.0 0.082 12.2 0.0 2.1 1 1 1 2 2 2 2 WD40-like domain PQQ_2 PF13360.6 CRG92691.1 - 0.0039 16.8 0.6 0.043 13.4 0.3 2.2 1 1 1 2 2 2 2 PQQ-like domain AAA_18 PF13238.6 CRG92691.1 - 0.0041 17.7 0.1 0.027 15.0 0.0 2.6 2 0 0 2 2 1 1 AAA domain AAA_33 PF13671.6 CRG92691.1 - 0.013 15.7 0.0 0.11 12.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 CRG92691.1 - 0.025 14.5 0.1 0.066 13.1 0.1 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase Cytidylate_kin PF02224.18 CRG92691.1 - 0.038 13.7 0.0 0.1 12.3 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase AAA PF00004.29 CRG92691.1 - 0.055 13.9 0.2 0.2 12.1 0.2 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 CRG92691.1 - 0.061 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain KAP_NTPase PF07693.14 CRG92691.1 - 0.069 12.4 3.0 0.081 12.1 1.1 1.8 1 1 1 2 2 2 0 KAP family P-loop domain AAA_24 PF13479.6 CRG92691.1 - 0.074 12.8 0.0 0.28 10.9 0.0 2.0 2 0 0 2 2 1 0 AAA domain PIF1 PF05970.14 CRG92691.1 - 0.12 11.5 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase Ge1_WD40 PF16529.5 CRG92691.1 - 0.17 10.8 0.0 5.9 5.7 0.0 2.6 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Phi29_Phage_SSB PF17427.2 CRG92691.1 - 0.19 11.9 0.0 0.86 9.8 0.0 2.1 3 0 0 3 3 2 0 Phage Single-stranded DNA-binding protein zf-CCHC_2 PF13696.6 CRG92691.1 - 0.21 11.5 2.6 0.43 10.5 2.6 1.5 1 0 0 1 1 1 0 Zinc knuckle Retro_M PF02813.14 CRG92691.1 - 0.31 11.5 1.0 19 5.7 0.0 3.2 1 1 2 3 3 3 0 Retroviral M domain zf-CCHC_5 PF14787.6 CRG92691.1 - 0.58 9.9 3.7 1.2 8.8 3.7 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger HeLo PF14479.6 CRG92692.1 - 2.1e-44 151.9 0.0 3.1e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Prion-inhibition and propagation Pkinase_Tyr PF07714.17 CRG92692.1 - 9.7e-05 21.8 0.0 0.00016 21.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CRG92692.1 - 0.0032 16.9 0.0 0.0052 16.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ank_2 PF12796.7 CRG92693.1 - 4.2e-34 117.0 6.7 2.1e-15 57.1 0.1 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Pkinase PF00069.25 CRG92693.1 - 1.5e-31 109.8 0.0 2.2e-31 109.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ank_4 PF13637.6 CRG92693.1 - 3.7e-21 75.2 1.2 9.9e-10 38.8 0.0 4.2 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG92693.1 - 5.1e-18 63.3 0.3 2.4e-05 24.3 0.0 5.1 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 CRG92693.1 - 9.6e-18 63.8 4.2 7.3e-05 23.0 0.0 4.7 2 1 2 4 4 4 4 Ankyrin repeat Pkinase_Tyr PF07714.17 CRG92693.1 - 2.2e-14 53.4 0.0 3.4e-14 52.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ank_5 PF13857.6 CRG92693.1 - 4.1e-14 52.5 2.3 2.3e-05 24.6 0.2 5.3 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Kdo PF06293.14 CRG92693.1 - 0.0042 16.5 1.8 0.065 12.6 0.0 2.8 2 1 1 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family DAGK_acc PF00609.19 CRG92695.1 - 0.034 14.5 0.0 0.04 14.2 0.0 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase accessory domain SelP_N PF04592.14 CRG92695.1 - 0.54 9.6 7.1 0.66 9.3 7.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNase_H PF00075.24 CRG92696.1 - 1.2e-08 35.3 0.0 4.3e-08 33.5 0.0 1.9 2 0 0 2 2 2 1 RNase H Zeta_toxin PF06414.12 CRG92696.1 - 0.078 12.2 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin ATP-grasp_4 PF13535.6 CRG92699.1 - 7.1e-11 42.0 0.0 1.5e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 CRG92699.1 - 5.1e-08 32.7 0.0 7.9e-08 32.1 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_N PF18130.1 CRG92699.1 - 2.9e-07 31.0 0.0 9.4e-07 29.3 0.0 1.9 2 0 0 2 2 2 1 ATP-grasp N-terminal domain GARS_A PF01071.19 CRG92699.1 - 2.2e-05 24.3 0.0 3.6e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 CRG92699.1 - 0.0011 19.0 0.0 0.0068 16.5 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 CRG92699.1 - 0.0094 15.5 0.0 0.022 14.2 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain adh_short PF00106.25 CRG92701.1 - 1e-11 44.7 0.0 1.4e-11 44.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92701.1 - 1e-08 35.1 0.1 1.3e-08 34.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 CRG92701.1 - 0.00084 18.9 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 CRG92701.1 - 0.0035 16.5 0.0 0.0044 16.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain DFP PF04127.15 CRG92701.1 - 0.059 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein KR PF08659.10 CRG92701.1 - 0.09 12.7 0.0 0.35 10.8 0.0 1.9 1 1 0 1 1 1 0 KR domain Helo_like_N PF17111.5 CRG92702.1 - 1.5e-34 119.2 0.2 2.4e-34 118.6 0.2 1.3 1 0 0 1 1 1 1 Fungal N-terminal domain of STAND proteins Glyco_hydro_127 PF07944.12 CRG92704.1 - 1.4e-113 380.2 0.3 1.7e-113 379.9 0.3 1.1 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Ank_4 PF13637.6 CRG92707.1 - 6.9e-14 52.0 0.0 6.4e-07 29.8 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 CRG92707.1 - 6.1e-11 42.8 0.0 1.7e-10 41.4 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 CRG92707.1 - 2.9e-10 40.1 0.0 1.9e-05 24.9 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 CRG92707.1 - 1.6e-09 37.2 0.0 0.0032 17.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 CRG92707.1 - 2.6e-07 30.8 0.0 3.1e-05 24.2 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) HC2 PF07382.11 CRG92707.1 - 0.023 14.8 2.1 0.033 14.3 2.1 1.1 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 Myb_DNA-bind_6 PF13921.6 CRG92708.1 - 0.0041 17.3 1.1 0.0079 16.4 1.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 CRG92708.1 - 0.17 12.1 0.2 0.29 11.4 0.2 1.3 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 APH PF01636.23 CRG92709.1 - 5.1e-10 39.7 0.0 8.7e-09 35.7 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 CRG92709.1 - 2.6e-06 27.2 0.0 3.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase PF00069.25 CRG92709.1 - 0.081 12.3 0.0 0.2 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein kinase domain Pinin_SDK_memA PF04696.13 CRG92710.1 - 0.0026 17.8 15.8 0.0031 17.5 15.8 1.1 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region DUF2052 PF09747.9 CRG92710.1 - 0.0083 16.3 16.3 0.012 15.7 16.3 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) RNA_pol_3_Rpc31 PF11705.8 CRG92710.1 - 0.018 15.3 15.5 0.021 15.1 15.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 CRG92710.1 - 0.031 12.5 12.0 0.029 12.6 12.0 1.0 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 CRG92710.1 - 0.051 12.6 14.0 0.048 12.7 14.0 1.1 1 0 0 1 1 1 0 Paf1 Spore_III_AF PF09581.10 CRG92710.1 - 0.098 12.7 10.6 0.15 12.0 10.6 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) RR_TM4-6 PF06459.12 CRG92710.1 - 0.11 12.3 10.8 0.12 12.2 10.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YqfD PF06898.11 CRG92710.1 - 0.13 11.0 9.7 0.16 10.8 9.7 1.2 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD CT47 PF15623.6 CRG92710.1 - 0.17 11.7 23.1 0.21 11.4 23.1 1.1 1 0 0 1 1 1 0 Cancer/testis gene family 47 PdaC PF13739.6 CRG92710.1 - 0.21 12.6 2.2 0.29 12.1 2.2 1.3 1 0 0 1 1 1 0 Deacetylase PdaC CDC45 PF02724.14 CRG92710.1 - 0.22 9.8 9.5 0.23 9.7 9.5 1.0 1 0 0 1 1 1 0 CDC45-like protein HSP70 PF00012.20 CRG92710.1 - 0.57 8.3 10.8 0.64 8.1 10.8 1.0 1 0 0 1 1 1 0 Hsp70 protein RNA_pol_Rpc4 PF05132.14 CRG92710.1 - 1.1 9.6 6.6 1.5 9.3 6.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 NPR3 PF03666.13 CRG92710.1 - 2.3 6.9 6.4 2.7 6.7 6.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 CRG92710.1 - 2.5 8.4 12.1 3 8.1 12.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 tRNA_bind_2 PF13725.6 CRG92710.1 - 2.8 7.6 14.6 3.8 7.1 14.6 1.1 1 0 0 1 1 1 0 Possible tRNA binding domain Pox_Ag35 PF03286.14 CRG92710.1 - 3.6 7.3 13.3 4.6 7.0 13.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.17 CRG92710.1 - 3.9 6.1 8.7 4.2 6.0 8.7 1.0 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 CRG92710.1 - 4 6.3 5.2 4.3 6.2 5.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFB6 PF17110.5 CRG92710.1 - 4.5 7.0 10.5 6.4 6.5 10.5 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4746 PF15928.5 CRG92710.1 - 4.6 6.6 19.5 5.8 6.3 19.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MAS20 PF02064.15 CRG92710.1 - 6.8 6.8 11.8 8.3 6.5 11.8 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor Med17 PF10156.9 CRG92710.1 - 7.4 5.1 12.5 8.4 5.0 12.5 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex TRAP_alpha PF03896.16 CRG92710.1 - 7.6 5.6 11.5 10 5.2 11.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TPR_10 PF13374.6 CRG92711.1 - 2.1e-82 269.0 13.4 6.4e-12 44.9 0.1 8.7 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_12 PF13424.6 CRG92711.1 - 2.7e-80 264.7 24.2 6.7e-19 68.0 1.5 6.1 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 CRG92711.1 - 1.3e-34 115.6 12.6 0.0004 20.2 0.0 8.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 CRG92711.1 - 3.3e-22 77.3 19.3 0.0022 17.7 0.1 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 CRG92711.1 - 1.9e-14 52.5 10.0 0.15 12.3 0.0 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 CRG92711.1 - 8.2e-14 51.4 0.5 2.9e-13 49.6 0.3 2.0 2 1 0 2 2 2 1 Phosphorylase superfamily TPR_2 PF07719.17 CRG92711.1 - 5.8e-11 41.6 19.5 1.1 9.6 0.1 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 CRG92711.1 - 5.5e-09 36.5 11.8 0.036 14.7 0.2 6.5 3 2 4 7 7 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 CRG92711.1 - 8.5e-09 35.5 23.2 1 10.3 0.1 8.6 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 CRG92711.1 - 4.6e-07 29.8 0.2 17 6.0 0.0 6.6 7 0 0 7 7 6 0 Tetratricopeptide repeat DUF1925 PF09094.11 CRG92711.1 - 1.2e-06 28.7 0.0 46 4.4 0.0 7.1 7 0 0 7 7 7 0 Domain of unknown function (DUF1925) TPR_4 PF07721.14 CRG92711.1 - 1.8e-05 24.9 0.0 1.3 9.9 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 CRG92711.1 - 2e-05 24.7 2.3 39 4.6 0.1 6.9 1 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Get5_bdg PF16843.5 CRG92711.1 - 6.2e-05 22.4 0.2 9.1 5.9 0.0 5.5 6 0 0 6 6 6 1 Binding domain to Get4 on Get5, Golgi to ER traffic protein NB-ARC PF00931.22 CRG92711.1 - 0.0007 18.8 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain NRBF2_MIT PF17169.4 CRG92711.1 - 0.00088 19.4 11.9 1.9 8.8 0.0 7.0 4 3 3 7 7 7 1 MIT domain of nuclear receptor-binding factor 2 AAA_16 PF13191.6 CRG92711.1 - 0.002 18.6 0.1 0.007 16.8 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain DUF1449 PF07290.11 CRG92711.1 - 0.08 12.6 0.1 1.1e+02 2.3 0.0 4.4 2 2 2 4 4 4 0 Protein of unknown function (DUF1449) Sfi1 PF08457.10 CRG92711.1 - 0.087 11.3 0.0 0.25 9.8 0.0 1.8 1 0 0 1 1 1 0 Sfi1 spindle body protein DDE_3 PF13358.6 CRG92712.1 - 4.5e-32 110.8 0.0 8.1e-32 110.0 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 CRG92712.1 - 1.6e-06 27.6 0.1 5.6e-06 25.9 0.1 1.9 1 0 0 1 1 1 1 Winged helix-turn helix rve PF00665.26 CRG92712.1 - 3.2e-06 27.3 0.0 5.3e-05 23.4 0.0 2.5 2 0 0 2 2 2 1 Integrase core domain DDE_1 PF03184.19 CRG92712.1 - 8e-05 22.4 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 CRG92712.1 - 0.0011 19.5 0.0 0.0038 17.8 0.0 2.0 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.6 CRG92712.1 - 0.0011 18.7 1.5 0.028 14.2 0.0 3.0 3 0 0 3 3 3 1 Homeodomain-like domain GerE PF00196.19 CRG92712.1 - 0.015 14.8 0.1 0.029 13.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family HTH_29 PF13551.6 CRG92712.1 - 0.019 15.0 0.2 0.057 13.4 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn helix DDE_Tnp_ISAZ013 PF07592.11 CRG92712.1 - 0.034 13.1 0.1 0.24 10.3 0.0 2.0 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain Cbl_N PF02262.16 CRG92712.1 - 0.07 13.1 0.0 0.6 10.1 0.0 2.2 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 DNA_pol3_theta PF06440.11 CRG92712.1 - 0.084 12.5 0.6 0.21 11.3 0.6 1.6 1 0 0 1 1 1 0 DNA polymerase III, theta subunit MFS_1 PF07690.16 CRG92713.1 - 1.1e-37 129.8 37.0 1.1e-37 129.8 37.0 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3017 PF11222.8 CRG92713.1 - 0.81 10.0 5.9 1.8 8.8 1.1 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3017) adh_short PF00106.25 CRG92714.1 - 4.9e-32 111.0 0.0 7.2e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92714.1 - 1e-26 94.0 0.0 1.2e-26 93.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92714.1 - 3.1e-10 40.3 0.1 4.1e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG92714.1 - 0.00057 19.8 0.4 0.00082 19.3 0.4 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 CRG92714.1 - 0.011 15.2 0.2 0.029 13.8 0.2 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Carn_acyltransf PF00755.20 CRG92715.1 - 1e-96 324.9 0.0 1.6e-96 324.3 0.0 1.3 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase ketoacyl-synt PF00109.26 CRG92715.1 - 2.9e-70 236.7 0.1 5.5e-70 235.8 0.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain PS-DH PF14765.6 CRG92715.1 - 3.5e-56 190.6 0.0 7.7e-56 189.5 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 CRG92715.1 - 2.8e-53 181.5 0.1 7.6e-53 180.1 0.1 1.8 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 CRG92715.1 - 5.7e-51 173.0 0.1 6.1e-50 169.6 0.0 2.6 2 0 0 2 2 2 1 KR domain Ketoacyl-synt_C PF02801.22 CRG92715.1 - 4.1e-38 130.0 0.3 1.5e-37 128.2 0.0 2.2 2 0 0 2 2 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 CRG92715.1 - 7.3e-18 65.1 0.0 1.8e-17 63.8 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 CRG92715.1 - 6.2e-10 39.1 0.0 3.7e-09 36.7 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG92715.1 - 1.8e-09 37.3 0.3 5.4e-08 32.5 0.1 2.6 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 CRG92715.1 - 1.2e-07 32.0 0.1 3.2e-07 30.6 0.1 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site ADH_zinc_N_2 PF13602.6 CRG92715.1 - 1.2e-06 29.7 0.0 9.1e-05 23.5 0.0 3.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short_C2 PF13561.6 CRG92715.1 - 5.2e-05 22.9 0.0 5.2e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_12 PF08242.12 CRG92715.1 - 0.00013 22.7 0.0 0.00045 20.9 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Thiolase_N PF00108.23 CRG92715.1 - 0.00048 19.6 0.2 0.0016 17.9 0.2 1.8 1 0 0 1 1 1 1 Thiolase, N-terminal domain Methyltransf_11 PF08241.12 CRG92715.1 - 0.0032 18.1 0.0 0.036 14.7 0.0 2.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92715.1 - 0.018 15.7 0.0 0.093 13.4 0.0 2.4 2 0 0 2 2 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CRG92715.1 - 0.05 12.9 0.0 0.17 11.2 0.0 1.8 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 CRG92715.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Epimerase PF01370.21 CRG92715.1 - 0.13 11.7 0.1 0.34 10.3 0.0 1.8 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Methyltransf_8 PF05148.15 CRG92715.1 - 0.19 11.5 0.0 0.41 10.4 0.0 1.4 1 0 0 1 1 1 0 Hypothetical methyltransferase adh_short PF00106.25 CRG92716.1 - 2.1e-30 105.6 0.0 2.5e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92716.1 - 1.2e-19 70.8 0.0 1.5e-19 70.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92716.1 - 5.8e-07 29.6 0.0 1.3e-06 28.4 0.0 1.6 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 CRG92716.1 - 0.0015 18.1 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 CRG92716.1 - 0.029 13.7 0.1 0.053 12.9 0.1 1.4 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) DUF2400 PF09674.10 CRG92716.1 - 0.094 12.7 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) RmlD_sub_bind PF04321.17 CRG92716.1 - 0.13 11.3 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain p450 PF00067.22 CRG92717.1 - 9.6e-35 120.2 0.2 6.7e-22 77.9 0.2 2.5 2 1 0 2 2 2 2 Cytochrome P450 FAD_binding_4 PF01565.23 CRG92718.1 - 1.3e-26 93.0 0.1 2.5e-26 92.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 CRG92718.1 - 2.5e-05 24.3 0.5 2.5e-05 24.3 0.5 2.3 2 0 0 2 2 2 1 Berberine and berberine like p450 PF00067.22 CRG92719.1 - 4.5e-51 174.0 0.0 1.8e-50 172.1 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 CRG92720.1 - 1.3e-09 37.5 0.0 2.5e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Methyltransf_2 PF00891.18 CRG92722.1 - 9e-21 74.1 0.0 1.4e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_25 PF13649.6 CRG92722.1 - 3.4e-05 24.5 0.0 0.0001 23.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG92722.1 - 0.001 18.6 0.0 0.0018 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 CRG92722.1 - 0.0012 18.6 0.0 0.0029 17.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_17 PF12692.7 CRG92722.1 - 0.037 14.0 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase Ubie_methyltran PF01209.18 CRG92722.1 - 0.048 13.0 0.0 0.094 12.0 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 CRG92722.1 - 0.12 11.4 0.0 0.22 10.6 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 CRG92722.1 - 0.13 13.1 0.0 0.36 11.6 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PS-DH PF14765.6 CRG92723.1 - 9.5e-75 251.6 0.0 1.5e-74 251.0 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 CRG92723.1 - 4.5e-65 219.7 0.0 9.1e-65 218.7 0.0 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 CRG92723.1 - 3.5e-55 186.7 0.5 7.4e-55 185.6 0.5 1.6 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 CRG92723.1 - 3.7e-53 181.1 0.1 6.6e-53 180.3 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 CRG92723.1 - 3.4e-32 110.9 0.0 7.7e-32 109.8 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 CRG92723.1 - 2.3e-19 70.0 0.0 4.8e-18 65.7 0.0 3.1 3 0 0 3 3 2 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 CRG92723.1 - 2.5e-15 56.9 0.1 1.4e-10 41.6 0.0 2.7 2 0 0 2 2 2 2 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 CRG92723.1 - 4.5e-12 46.1 0.0 3.7e-11 43.2 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92723.1 - 1.5e-09 38.4 0.0 1.7e-08 35.1 0.0 2.9 3 0 0 3 3 2 1 Methyltransferase domain adh_short PF00106.25 CRG92723.1 - 1.1e-08 34.7 0.3 4.5e-08 32.8 0.1 2.1 3 0 0 3 3 2 1 short chain dehydrogenase Methyltransf_31 PF13847.6 CRG92723.1 - 1.4e-08 34.7 0.0 2.8e-07 30.4 0.0 2.9 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92723.1 - 1.8e-08 34.9 0.0 2.4e-07 31.3 0.0 3.1 3 0 0 3 3 2 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 CRG92723.1 - 5e-07 29.1 0.0 8.3e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein ADH_zinc_N PF00107.26 CRG92723.1 - 8.6e-07 29.0 0.0 2.1e-05 24.5 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PP-binding PF00550.25 CRG92723.1 - 1.2e-06 28.7 0.4 1.3e-05 25.4 0.2 2.8 2 0 0 2 2 2 1 Phosphopantetheine attachment site adh_short_C2 PF13561.6 CRG92723.1 - 4.7e-05 23.1 0.1 0.00012 21.7 0.1 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3Beta_HSD PF01073.19 CRG92723.1 - 6.2e-05 22.1 0.0 0.00011 21.3 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Thiolase_N PF00108.23 CRG92723.1 - 0.0004 19.8 0.3 0.00098 18.6 0.3 1.6 1 0 0 1 1 1 1 Thiolase, N-terminal domain ADH_zinc_N_2 PF13602.6 CRG92723.1 - 0.00042 21.4 0.0 0.5 11.4 0.0 3.2 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Ubie_methyltran PF01209.18 CRG92723.1 - 0.0011 18.4 0.0 0.0048 16.3 0.0 1.9 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family ADH_N PF08240.12 CRG92723.1 - 0.0017 18.2 0.1 0.0037 17.1 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ACP_syn_III PF08545.10 CRG92723.1 - 0.0042 16.9 0.2 0.011 15.6 0.2 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Methyltransf_2 PF00891.18 CRG92723.1 - 0.15 11.3 0.1 0.63 9.3 0.1 2.0 1 1 0 1 1 1 0 O-methyltransferase domain DUF3435 PF11917.8 CRG92724.1 - 1.5e-147 491.9 0.2 1.8e-147 491.6 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3435) Dimer_Tnp_hAT PF05699.14 CRG92724.1 - 0.043 13.6 0.1 0.21 11.4 0.0 2.2 2 1 1 3 3 3 0 hAT family C-terminal dimerisation region zf-C2H2_4 PF13894.6 CRG92724.1 - 0.69 10.9 3.4 6.4 7.9 0.1 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger RdRP PF05183.12 CRG92726.1 - 4.5e-179 596.9 0.0 5.6e-179 596.6 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase DUF726 PF05277.12 CRG92726.1 - 0.19 10.6 0.9 0.37 9.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF726) Ribonuclease_3 PF00636.26 CRG92727.1 - 4.4e-05 24.0 0.1 0.00059 20.4 0.1 2.1 1 1 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 CRG92727.1 - 6.6e-05 23.1 0.0 0.0001 22.4 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like C-C_Bond_Lyase PF15617.6 CRG92727.1 - 0.13 11.4 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold CHAT PF12770.7 CRG92728.1 - 1.3e-07 31.3 0.0 2.2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 CHAT domain DJ-1_PfpI PF01965.24 CRG92729.1 - 4.5e-05 23.3 0.0 6.2e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 DJ-1/PfpI family TPR_12 PF13424.6 CRG92730.1 - 2.4e-72 239.2 1.7 1.6e-15 57.1 0.0 6.3 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 CRG92730.1 - 2.9e-71 233.6 0.0 1e-12 47.4 0.0 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 CRG92730.1 - 2e-26 90.0 0.2 0.00055 19.8 0.0 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 CRG92730.1 - 5.8e-17 60.4 1.0 0.0066 16.5 0.0 6.4 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 CRG92730.1 - 7e-16 57.3 1.3 0.0087 15.8 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 CRG92730.1 - 2.9e-12 46.4 0.0 5e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Phosphorylase superfamily TPR_17 PF13431.6 CRG92730.1 - 9.3e-11 41.3 3.8 0.89 10.1 0.0 6.7 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 CRG92730.1 - 1e-10 42.1 0.3 0.0021 18.7 0.0 5.6 3 2 0 4 4 4 2 Tetratricopeptide repeat NB-ARC PF00931.22 CRG92730.1 - 2e-10 40.3 0.0 3.4e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain TPR_MalT PF17874.1 CRG92730.1 - 2e-10 40.6 3.2 2.4e-06 27.2 0.8 2.6 1 1 1 2 2 2 2 MalT-like TPR region TPR_19 PF14559.6 CRG92730.1 - 3.4e-10 40.3 0.4 0.0088 16.5 0.0 6.1 2 1 4 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 CRG92730.1 - 1.3e-09 37.5 4.4 0.33 11.3 0.1 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_4 PF07721.14 CRG92730.1 - 1.3e-09 37.7 0.0 0.65 10.8 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 CRG92730.1 - 1.4e-08 34.8 2.6 1.2 10.1 0.0 6.7 5 1 1 6 6 6 1 Tetratricopeptide repeat AAA_16 PF13191.6 CRG92730.1 - 9.3e-08 32.6 0.3 1.6e-06 28.7 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 CRG92730.1 - 2.7e-05 24.2 0.0 7.2e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 NACHT domain TPR_5 PF12688.7 CRG92730.1 - 9e-05 22.7 0.0 1.5 9.1 0.0 4.2 2 1 2 4 4 4 1 Tetratrico peptide repeat ANAPC3 PF12895.7 CRG92730.1 - 0.00016 21.8 0.1 0.1 12.8 0.0 4.2 1 1 3 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 CRG92730.1 - 0.0002 21.8 6.3 1.8 9.3 0.0 6.5 7 0 0 7 7 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 CRG92730.1 - 0.00044 20.2 0.0 8.2 6.5 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat AAA_22 PF13401.6 CRG92730.1 - 0.00069 19.9 0.0 0.0022 18.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain PPR PF01535.20 CRG92730.1 - 0.0018 18.4 0.0 46 4.6 0.0 5.6 5 0 0 5 5 5 0 PPR repeat ATPase_2 PF01637.18 CRG92730.1 - 0.0041 17.1 0.0 0.016 15.1 0.0 2.0 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea ParA PF10609.9 CRG92730.1 - 0.024 14.1 0.0 0.047 13.1 0.0 1.4 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase RPN6_N PF18055.1 CRG92730.1 - 0.026 14.9 0.0 11 6.4 0.0 3.1 2 1 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain SRP54 PF00448.22 CRG92730.1 - 0.044 13.4 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 CRG92730.1 - 0.057 14.0 0.1 0.3 11.6 0.0 2.4 2 0 0 2 2 1 0 AAA domain Diacid_rec PF05651.13 CRG92730.1 - 0.11 12.2 0.0 45 3.7 0.0 3.4 2 1 1 3 3 3 0 Putative sugar diacid recognition BTB PF00651.31 CRG92731.1 - 9.9e-05 22.5 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Ank_2 PF12796.7 CRG92732.1 - 8.7e-06 26.2 0.0 0.051 14.2 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) DUF155 PF02582.14 CRG92732.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.5 1 1 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 WD40 PF00400.32 CRG92733.1 - 4.4e-159 511.5 59.0 9.3e-11 42.1 0.1 17.4 17 0 0 17 17 17 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG92733.1 - 3e-60 200.5 16.7 1.2e-05 25.5 0.0 14.8 1 1 14 15 15 15 13 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 CRG92733.1 - 7.6e-46 156.9 62.0 0.0012 17.6 0.4 15.1 1 1 13 15 15 15 15 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 CRG92733.1 - 1.9e-21 76.4 41.0 0.0002 20.5 1.1 10.6 1 1 11 12 12 12 11 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 CRG92733.1 - 2.8e-18 66.3 17.2 0.0003 20.2 0.3 7.9 3 2 6 9 9 9 4 WD40-like domain PNP_UDP_1 PF01048.20 CRG92733.1 - 1e-12 47.8 0.0 2.2e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily Cation_ATPase PF13246.6 CRG92733.1 - 5.8e-11 42.3 0.0 8.6 6.5 0.0 10.1 2 2 5 10 10 10 1 Cation transport ATPase (P-type) Cytochrom_D1 PF02239.16 CRG92733.1 - 1e-07 30.9 7.3 0.12 10.9 0.2 6.0 1 1 7 8 8 8 3 Cytochrome D1 heme domain NACHT PF05729.12 CRG92733.1 - 1.5e-06 28.2 0.0 3.7e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 CRG92733.1 - 2.6e-06 27.9 0.0 7.7e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain VID27 PF08553.10 CRG92733.1 - 6.9e-06 25.4 25.4 0.34 9.9 0.1 7.1 1 1 6 8 8 8 4 VID27 C-terminal WD40-like domain HARP PF07443.13 CRG92733.1 - 0.00035 20.1 1.5 19 5.0 0.0 6.8 7 0 0 7 7 7 0 HepA-related protein (HARP) AAA_18 PF13238.6 CRG92733.1 - 0.00063 20.3 0.0 0.0046 17.5 0.0 2.4 2 1 0 2 2 2 1 AAA domain WXG100 PF06013.12 CRG92733.1 - 0.019 15.2 0.0 2.7e+02 1.9 0.0 6.6 7 0 0 7 7 7 0 Proteins of 100 residues with WXG SAND PF01342.21 CRG92733.1 - 0.045 13.4 15.8 1.9 8.3 0.3 5.6 5 1 0 5 5 5 0 SAND domain APS_kinase PF01583.20 CRG92733.1 - 0.18 11.7 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase FLgD_tudor PF13861.6 CRG92733.1 - 0.36 11.1 10.6 1.2e+02 3.0 0.0 8.0 12 0 0 12 12 11 0 FlgD Tudor-like domain DUF746 PF05344.11 CRG92734.1 - 0.15 11.9 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) VanY PF02557.17 CRG92735.1 - 0.1 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase RVT_1 PF00078.27 CRG92736.1 - 4.4e-17 62.3 0.0 8.8e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Helo_like_N PF17111.5 CRG92736.1 - 8.8 5.6 12.6 0.06 12.7 3.0 2.1 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins AAL_decarboxy PF03306.13 CRG92737.1 - 0.17 11.2 0.0 0.29 10.4 0.0 1.3 1 0 0 1 1 1 0 Alpha-acetolactate decarboxylase AAA PF00004.29 CRG92738.1 - 4.2e-44 150.2 0.0 1.4e-13 51.4 0.0 5.8 5 0 0 5 5 5 4 ATPase family associated with various cellular activities (AAA) AAA_12 PF13087.6 CRG92738.1 - 3.9e-41 140.9 0.1 1.9e-40 138.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 CRG92738.1 - 9.3e-29 101.0 24.5 1.4e-25 90.5 0.0 6.2 6 0 0 6 6 6 2 AAA domain AAA_lid_6 PF17866.1 CRG92738.1 - 3.6e-16 59.1 10.6 5.1e-10 39.4 0.3 4.8 4 0 0 4 4 4 2 AAA lid domain AAA_30 PF13604.6 CRG92738.1 - 4.7e-16 59.1 0.1 0.00012 21.9 0.0 5.6 5 0 0 5 5 5 4 AAA domain AAA_19 PF13245.6 CRG92738.1 - 8.3e-15 55.4 0.0 9.2e-06 26.1 0.0 5.3 4 1 0 4 4 4 2 AAA domain AAA_5 PF07728.14 CRG92738.1 - 8.9e-13 48.4 0.9 0.029 14.4 0.1 5.3 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 CRG92738.1 - 2.3e-09 37.7 9.7 0.096 13.0 0.1 7.1 4 3 2 6 6 5 3 AAA domain Mg_chelatase PF01078.21 CRG92738.1 - 3.4e-09 36.4 0.1 0.33 10.3 0.0 4.8 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 CRG92738.1 - 6.5e-08 32.5 0.3 0.62 9.8 0.0 4.6 4 0 0 4 4 4 2 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 CRG92738.1 - 1e-07 32.3 0.2 1.5 9.2 0.0 4.8 4 0 0 4 4 4 1 RNA helicase Viral_helicase1 PF01443.18 CRG92738.1 - 1.6e-06 28.0 0.8 0.15 11.8 0.0 5.3 6 0 0 6 6 5 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 CRG92738.1 - 3.3e-06 27.0 0.0 2.2 7.9 0.0 4.6 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_16 PF13191.6 CRG92738.1 - 3.3e-06 27.6 13.1 0.7 10.3 0.1 6.5 6 0 0 6 6 6 2 AAA ATPase domain ResIII PF04851.15 CRG92738.1 - 3.6e-06 27.1 1.8 0.008 16.2 0.0 5.4 5 0 0 5 5 4 1 Type III restriction enzyme, res subunit Sigma54_activat PF00158.26 CRG92738.1 - 1.7e-05 24.6 0.2 16 5.2 0.0 5.6 5 0 0 5 5 5 0 Sigma-54 interaction domain AAA_7 PF12775.7 CRG92738.1 - 2e-05 24.2 0.5 15 5.1 0.0 4.7 4 0 0 4 4 4 0 P-loop containing dynein motor region Torsin PF06309.11 CRG92738.1 - 5e-05 23.4 0.1 10 6.3 0.0 4.7 4 0 0 4 4 4 0 Torsin AAA_24 PF13479.6 CRG92738.1 - 0.00021 21.1 10.4 1.8 8.2 0.1 6.3 6 1 1 7 7 7 2 AAA domain PhoH PF02562.16 CRG92738.1 - 0.0003 20.3 0.1 4.9 6.5 0.0 4.5 4 0 0 4 4 4 1 PhoH-like protein AAA_18 PF13238.6 CRG92738.1 - 0.00032 21.3 10.5 5.4 7.6 0.1 5.8 5 0 0 5 5 5 0 AAA domain DUF2075 PF09848.9 CRG92738.1 - 0.0037 16.6 0.0 0.0037 16.6 0.0 5.9 6 1 0 6 6 6 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 CRG92738.1 - 0.0064 16.4 0.0 0.056 13.3 0.0 2.7 2 0 0 2 2 2 1 Helicase AAA_33 PF13671.6 CRG92738.1 - 0.02 15.1 20.5 3.9 7.6 0.0 6.8 6 0 0 6 6 6 0 AAA domain Adeno_IVa2 PF02456.15 CRG92738.1 - 0.026 13.3 0.0 0.13 11.1 0.0 2.0 2 0 0 2 2 2 0 Adenovirus IVa2 protein RsgA_GTPase PF03193.16 CRG92738.1 - 0.035 14.0 0.0 4.3 7.2 0.0 3.7 4 0 0 4 4 4 0 RsgA GTPase AAA_6 PF12774.7 CRG92738.1 - 0.049 12.6 0.1 7.6 5.4 0.0 3.4 4 0 0 4 4 3 0 Hydrolytic ATP binding site of dynein motor region AAA_29 PF13555.6 CRG92738.1 - 0.12 12.1 0.8 20 5.0 0.0 3.6 4 0 0 4 4 4 0 P-loop containing region of AAA domain Rad17 PF03215.15 CRG92738.1 - 0.27 11.1 2.2 4.5 7.1 0.0 3.8 5 1 0 5 5 4 0 Rad17 P-loop domain zf-NF-X1 PF01422.17 CRG92738.1 - 1.5 9.0 6.7 4.3 7.5 6.7 1.8 1 0 0 1 1 1 0 NF-X1 type zinc finger NACHT PF05729.12 CRG92738.1 - 1.7 8.5 5.5 58 3.6 0.0 4.6 5 0 0 5 5 4 0 NACHT domain ABC_tran PF00005.27 CRG92738.1 - 1.9 9.0 12.8 13 6.3 0.1 5.5 5 1 0 5 5 4 0 ABC transporter AAA_25 PF13481.6 CRG92738.1 - 2.2 7.8 10.8 2 7.9 0.0 4.0 5 0 0 5 5 4 0 AAA domain SRP54 PF00448.22 CRG92738.1 - 2.6 7.6 4.8 18 4.9 0.0 3.7 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain FA_hydroxylase PF04116.13 CRG92739.1 - 1.2e-15 58.0 9.9 1.2e-15 58.0 9.9 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily DUF3435 PF11917.8 CRG92739.1 - 0.045 12.7 0.0 0.064 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) Orn_Arg_deC_N PF02784.16 CRG92743.1 - 9.8e-37 126.6 0.0 1.2e-36 126.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Pkinase PF00069.25 CRG92744.1 - 2.4e-70 236.9 0.0 3.5e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 CRG92744.1 - 3e-44 151.2 0.0 4.5e-44 150.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 CRG92744.1 - 4.7e-08 32.7 0.0 2e-07 30.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 CRG92744.1 - 0.00082 18.8 0.1 0.0015 17.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 CRG92744.1 - 0.0048 16.5 0.4 0.052 13.2 0.1 2.1 1 1 1 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 CRG92744.1 - 0.042 13.5 0.3 0.41 10.2 0.0 2.1 1 1 1 2 2 2 0 RIO1 family YrbL-PhoP_reg PF10707.9 CRG92744.1 - 0.045 13.3 0.8 0.18 11.3 0.8 2.0 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 CRG92744.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 CRG92744.1 - 0.15 11.9 0.1 0.37 10.7 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family F-box-like PF12937.7 CRG92745.1 - 5.2e-06 26.2 0.2 1.3e-05 24.9 0.2 1.8 1 0 0 1 1 1 1 F-box-like BAR_3 PF16746.5 CRG92745.1 - 0.1 12.3 0.1 1.1 8.9 0.0 2.3 2 1 0 3 3 3 0 BAR domain of APPL family TraW_N PF12477.8 CRG92746.1 - 0.53 10.3 3.5 0.61 10.1 0.0 2.9 3 0 0 3 3 3 0 Sex factor F TraW protein N terminal RTA1 PF04479.13 CRG92747.1 - 3.5e-28 98.6 11.8 3.5e-28 98.6 11.8 1.7 2 0 0 2 2 2 1 RTA1 like protein UQ_con PF00179.26 CRG92747.1 - 1.2e-18 67.2 0.2 2e-18 66.4 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Cyto_heme_lyase PF01265.17 CRG92749.1 - 6.1e-125 416.6 1.3 7e-125 416.4 1.3 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase ABC1 PF03109.16 CRG92750.1 - 4.4e-21 75.2 0.0 3.6e-12 46.5 0.0 2.5 2 0 0 2 2 2 2 ABC1 family RIO1 PF01163.22 CRG92750.1 - 0.011 15.3 0.1 0.16 11.5 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Raf1_HTH PF18579.1 CRG92750.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain DUF3245 PF11595.8 CRG92752.1 - 6e-38 130.7 7.4 6e-38 130.7 7.4 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3245) HSF_DNA-bind PF00447.17 CRG92753.1 - 3e-30 104.7 5.5 3.3e-30 104.6 1.8 2.2 2 0 0 2 2 2 1 HSF-type DNA-binding F-box PF00646.33 CRG92754.1 - 0.00033 20.4 0.4 0.00079 19.3 0.4 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 CRG92754.1 - 0.00043 20.1 1.3 0.00043 20.1 1.3 2.0 2 0 0 2 2 2 1 F-box-like ATP-grasp_2 PF08442.10 CRG92755.1 - 1.3e-76 256.7 1.1 2.8e-76 255.6 0.3 1.8 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 CRG92755.1 - 8.2e-24 84.2 0.2 1.7e-23 83.1 0.2 1.6 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 CRG92755.1 - 5.7e-08 32.5 0.3 1.6e-07 31.0 0.2 1.7 2 1 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 CRG92755.1 - 0.00087 19.1 0.9 0.027 14.2 0.3 2.5 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain VID27_N PF17748.1 CRG92755.1 - 0.19 11.5 1.5 0.37 10.6 1.5 1.4 1 0 0 1 1 1 0 VID27 N-terminal region SLAC1 PF03595.17 CRG92756.1 - 5.3e-79 265.8 49.0 6.2e-79 265.6 49.0 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel Pribosyltran PF00156.27 CRG92757.1 - 1.5e-06 27.8 0.0 2.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PTRF_SDPR PF15237.6 CRG92757.1 - 0.043 13.4 0.1 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 PTRF/SDPR family DPM3 PF08285.11 CRG92758.1 - 7.7e-32 109.4 0.1 8.5e-32 109.2 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) LapA_dom PF06305.11 CRG92758.1 - 0.0069 16.2 0.1 0.015 15.1 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain DUF1043 PF06295.12 CRG92758.1 - 0.013 15.5 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) NIL PF09383.10 CRG92758.1 - 0.027 14.3 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 NIL domain Phage_holin_3_6 PF07332.11 CRG92758.1 - 0.037 14.0 0.5 0.064 13.3 0.5 1.3 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III LGT PF01790.18 CRG92758.1 - 0.049 12.9 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 Prolipoprotein diacylglyceryl transferase KAP PF05804.12 CRG92759.1 - 2.1e-06 26.2 1.0 1.9e-05 23.0 0.4 2.1 2 0 0 2 2 2 1 Kinesin-associated protein (KAP) DRIM PF07539.12 CRG92759.1 - 0.0023 16.3 0.4 0.0023 16.3 0.4 2.4 3 1 0 3 3 3 1 Down-regulated in metastasis Arm PF00514.23 CRG92759.1 - 0.028 14.5 5.2 21 5.3 0.1 5.5 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat SYCP2_ARLD PF18581.1 CRG92759.1 - 0.032 14.2 0.1 0.032 14.2 0.1 1.9 2 0 0 2 2 2 0 Synaptonemal complex 2 armadillo-repeat-like domain Oxidored-like PF09791.9 CRG92760.1 - 2.6e-24 84.6 2.4 5.6e-24 83.5 2.4 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF4393 PF14337.6 CRG92761.1 - 0.021 14.7 0.0 0.19 11.5 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4393) Ribosomal_L13e PF01294.18 CRG92762.1 - 7.5e-75 250.7 6.4 1.1e-74 250.1 6.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e APC_N_CC PF16689.5 CRG92763.1 - 0.036 14.1 1.0 0.036 14.1 1.0 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain Rootletin PF15035.6 CRG92763.1 - 0.72 9.9 15.5 0.18 11.8 11.0 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion LRR_4 PF12799.7 CRG92764.1 - 2e-27 94.8 61.5 6.3e-05 23.3 3.6 10.4 4 3 8 13 13 13 12 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 CRG92764.1 - 2.9e-26 91.0 56.9 7.7e-06 25.6 10.3 8.8 5 2 5 10 10 10 9 Leucine rich repeat LRR_9 PF14580.6 CRG92764.1 - 0.031 13.8 20.2 4.5 6.7 0.6 5.0 3 1 3 6 6 6 0 Leucine-rich repeat LRR_1 PF00560.33 CRG92764.1 - 0.061 13.9 52.3 5.1 8.0 0.3 12.6 11 2 0 11 11 11 0 Leucine Rich Repeat GCIP PF13324.6 CRG92765.1 - 2.4e-25 89.7 3.9 3.9e-25 89.0 3.9 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting YL1 PF05764.13 CRG92765.1 - 0.0045 17.1 3.1 0.0057 16.8 3.1 1.2 1 0 0 1 1 1 1 YL1 nuclear protein RRN3 PF05327.11 CRG92765.1 - 0.16 10.5 4.2 0.29 9.6 4.2 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4611 PF15387.6 CRG92765.1 - 0.2 11.9 9.5 0.17 12.1 4.5 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Actin PF00022.19 CRG92766.1 - 4.8e-106 354.8 0.0 2.6e-105 352.4 0.0 1.8 1 1 0 1 1 1 1 Actin 3HCDH_N PF02737.18 CRG92767.1 - 2.1e-53 180.9 0.5 2.8e-53 180.5 0.5 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 CRG92767.1 - 8.6e-34 116.0 0.0 2.4e-33 114.6 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 CRG92767.1 - 0.0005 20.3 0.2 0.0015 18.7 0.2 1.8 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 CRG92767.1 - 0.00063 20.0 0.1 0.0013 19.0 0.1 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DAO PF01266.24 CRG92767.1 - 0.0098 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 CRG92767.1 - 0.012 14.9 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 CRG92767.1 - 0.04 13.9 0.0 0.065 13.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 CRG92767.1 - 0.05 13.2 0.2 0.11 12.0 0.2 1.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FeoC PF09012.10 CRG92767.1 - 0.07 13.2 0.0 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 FeoC like transcriptional regulator 2-Hacid_dh_C PF02826.19 CRG92767.1 - 0.092 12.1 0.4 0.18 11.1 0.1 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.17 CRG92767.1 - 0.12 13.0 4.4 1.8 9.2 3.0 3.0 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TIMELESS PF04821.14 CRG92768.1 - 7e-90 301.0 0.0 7e-90 301.0 0.0 2.9 3 0 0 3 3 3 2 Timeless protein TIMELESS_C PF05029.13 CRG92768.1 - 8.5e-51 173.8 2.5 6.7e-41 141.1 0.0 4.0 2 1 2 4 4 4 2 Timeless protein C terminal region PhzC-PhzF PF02567.16 CRG92769.1 - 7.2e-37 127.4 0.2 6.2e-36 124.3 0.2 1.9 1 1 0 1 1 1 1 Phenazine biosynthesis-like protein Tfb2 PF03849.14 CRG92770.1 - 2.1e-137 457.9 0.6 2.8e-137 457.4 0.3 1.3 2 0 0 2 2 2 1 Transcription factor Tfb2 Tfb2_C PF18307.1 CRG92770.1 - 1.5e-24 86.2 0.9 3e-24 85.2 0.9 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 CRG92770.1 - 2.6e-05 24.4 0.0 8.2e-05 22.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain 4HBT PF03061.22 CRG92771.1 - 4.2e-14 52.7 0.0 6.1e-14 52.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 CRG92771.1 - 0.037 14.2 0.0 0.049 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) Aquarius_N PF16399.5 CRG92772.1 - 0 1079.8 0.0 0 1079.4 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 CRG92772.1 - 1.8e-27 96.3 0.0 3.1e-27 95.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 CRG92772.1 - 1.1e-22 81.1 0.0 2.2e-22 80.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 CRG92772.1 - 8.2e-07 28.9 0.0 0.00036 20.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 CRG92772.1 - 1.5e-06 28.4 0.0 3.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 CRG92772.1 - 5e-06 26.9 0.0 1.3e-05 25.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 CRG92772.1 - 0.0012 19.2 0.1 0.0047 17.3 0.0 2.0 2 0 0 2 2 1 1 AAA ATPase domain DnaB_C PF03796.15 CRG92772.1 - 0.0014 18.0 0.0 0.0034 16.8 0.0 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA PF00004.29 CRG92772.1 - 0.0018 18.7 0.0 0.0048 17.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 CRG92772.1 - 0.006 16.4 0.3 0.016 15.0 0.3 1.8 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD-helicase PF00580.21 CRG92772.1 - 0.0065 16.0 0.0 0.018 14.6 0.0 1.8 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 CRG92772.1 - 0.011 16.0 0.3 0.092 13.0 0.1 2.5 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.9 CRG92772.1 - 0.017 14.4 1.3 0.027 13.7 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 CRG92772.1 - 0.031 14.1 0.0 0.066 13.0 0.0 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 CRG92772.1 - 0.038 13.7 0.1 4.1 7.1 0.0 3.0 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 CRG92772.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PIF1 PF05970.14 CRG92772.1 - 0.12 11.5 0.0 11 5.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase NB-ARC PF00931.22 CRG92772.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 CRG92772.1 - 0.14 12.5 0.0 0.73 10.3 0.0 2.2 3 0 0 3 3 2 0 RNA helicase Parvo_NS1 PF01057.17 CRG92772.1 - 0.17 11.0 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 CRG92772.1 - 0.19 11.0 0.0 0.38 10.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin efThoc1 PF11957.8 CRG92773.1 - 4.1e-152 507.3 5.2 4.1e-152 507.3 5.2 1.5 1 1 1 2 2 2 1 THO complex subunit 1 transcription elongation factor MGC-24 PF05283.11 CRG92773.1 - 0.7 10.3 3.2 15 6.1 0.4 3.0 3 0 0 3 3 3 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Homeodomain PF00046.29 CRG92774.1 - 1.2e-16 60.3 4.0 2.1e-16 59.5 4.0 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 CRG92774.1 - 0.077 12.9 0.8 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 Homeobox KN domain Cutinase PF01083.22 CRG92775.1 - 7.3e-50 169.4 0.6 8.5e-50 169.2 0.6 1.0 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 CRG92775.1 - 0.04 13.5 0.0 0.054 13.0 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain VirJ PF06057.11 CRG92775.1 - 0.077 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial virulence protein (VirJ) Adaptin_N PF01602.20 CRG92776.1 - 1.6e-126 423.0 4.5 1.8e-126 422.8 4.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 CRG92776.1 - 1.8e-44 150.5 0.0 4.6e-44 149.2 0.0 1.7 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 CRG92776.1 - 7.1e-19 68.2 0.0 2.9e-18 66.2 0.0 2.1 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 CRG92776.1 - 0.00027 21.0 2.0 0.016 15.3 0.2 2.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 CRG92776.1 - 0.062 13.0 0.0 9.7 5.9 0.0 2.9 2 1 0 2 2 2 0 rRNA processing/ribosome biogenesis HEAT PF02985.22 CRG92776.1 - 0.17 12.2 0.2 6.7 7.3 0.0 3.8 5 0 0 5 5 5 0 HEAT repeat Ala_racemase_N PF01168.20 CRG92777.1 - 6.5e-24 84.8 0.1 7.6e-24 84.6 0.1 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Hist_deacetyl PF00850.19 CRG92779.1 - 3.5e-52 177.8 0.0 8e-52 176.6 0.0 1.6 1 0 0 1 1 1 1 Histone deacetylase domain SWIRM-assoc_1 PF16495.5 CRG92779.1 - 0.092 12.7 0.3 0.23 11.4 0.3 1.6 1 0 0 1 1 1 0 SWIRM-associated region 1 Pkinase PF00069.25 CRG92780.1 - 1.2e-06 28.1 0.0 3e-06 26.8 0.0 1.6 1 1 1 2 2 2 1 Protein kinase domain APH PF01636.23 CRG92780.1 - 0.00014 21.8 0.1 0.00024 21.1 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 CRG92780.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase Choline_kinase PF01633.20 CRG92780.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 CRG92780.1 - 0.044 13.1 0.0 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-AN1 PF01428.16 CRG92781.1 - 1.4e-23 82.8 25.6 1e-11 44.8 8.4 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger zf-C5HC2 PF02928.16 CRG92781.1 - 0.0024 18.2 9.6 0.25 11.8 1.3 2.4 2 0 0 2 2 2 2 C5HC2 zinc finger Transp_Tc5_C PF04236.15 CRG92781.1 - 0.33 11.3 13.9 0.7 10.3 3.1 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain IBR PF01485.21 CRG92781.1 - 0.33 11.2 22.3 0.062 13.5 5.8 3.0 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Methyltransf_23 PF13489.6 CRG92782.1 - 5.7e-17 62.0 0.1 1.8e-16 60.4 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92782.1 - 6.6e-10 39.6 0.1 2.4e-09 37.8 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92782.1 - 2e-05 25.1 0.0 4.3e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 CRG92782.1 - 5.6e-05 22.6 0.1 0.0023 17.3 0.0 2.3 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 CRG92782.1 - 0.00022 21.9 0.0 0.00093 19.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92782.1 - 0.00035 20.4 0.1 0.076 12.8 0.1 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.17 CRG92782.1 - 0.005 16.3 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase FtsJ PF01728.19 CRG92782.1 - 0.0086 16.2 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase CMAS PF02353.20 CRG92782.1 - 0.051 12.9 0.0 0.56 9.4 0.0 2.1 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 CRG92782.1 - 0.076 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain GFO_IDH_MocA PF01408.22 CRG92783.1 - 6.3e-23 81.9 0.1 2.5e-22 79.9 0.1 1.9 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 CRG92783.1 - 0.06 14.0 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain MARVEL PF01284.23 CRG92784.1 - 1.8e-06 28.0 16.7 2.8e-06 27.4 16.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain DUF4231 PF14015.6 CRG92784.1 - 5.3 7.6 7.3 1.2 9.6 1.4 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF4231) Ank_2 PF12796.7 CRG92785.1 - 4.9e-45 152.0 0.0 2.9e-11 43.8 0.0 5.5 3 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG92785.1 - 4.9e-26 90.8 0.7 3.2e-06 27.6 0.0 7.2 4 2 3 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG92785.1 - 5.3e-24 81.7 0.4 0.13 12.9 0.0 9.4 9 0 0 9 9 9 6 Ankyrin repeat Ank_5 PF13857.6 CRG92785.1 - 3.9e-21 74.8 3.7 2.9e-07 30.6 0.2 6.1 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank PF00023.30 CRG92785.1 - 2.2e-19 68.9 1.8 0.019 15.4 0.0 9.1 9 0 0 9 9 9 5 Ankyrin repeat Chitin_synth_1 PF01644.17 CRG92786.1 - 6.7e-78 260.3 0.2 9.6e-78 259.8 0.2 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 CRG92786.1 - 1.2e-27 95.7 0.2 2.5e-27 94.6 0.2 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 CRG92786.1 - 1.1e-24 87.0 0.3 1.2e-19 70.4 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 CRG92786.1 - 2.3e-07 30.9 0.2 5.7e-07 29.6 0.2 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 DUF1774 PF08611.10 CRG92787.1 - 1.9e-33 114.6 4.8 1.9e-33 114.6 4.8 2.7 3 1 0 3 3 3 1 Fungal protein of unknown function (DUF1774) MFS_1 PF07690.16 CRG92788.1 - 5.3e-36 124.3 80.2 2.2e-34 119.0 48.8 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Inositol_P PF00459.25 CRG92790.1 - 4.9e-41 141.0 1.5 3.1e-40 138.4 1.5 1.8 1 1 0 1 1 1 1 Inositol monophosphatase family Peptidase_M28 PF04389.17 CRG92791.1 - 3.5e-29 101.9 0.1 5.2e-29 101.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 CRG92791.1 - 1e-05 25.3 0.1 2e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Carbpep_Y_N PF05388.11 CRG92791.1 - 0.068 13.7 0.7 0.51 10.9 0.3 2.5 3 0 0 3 3 3 0 Carboxypeptidase Y pro-peptide Uteroglobin PF01099.17 CRG92791.1 - 0.13 12.6 0.1 0.81 10.1 0.0 2.3 1 1 1 2 2 2 0 Uteroglobin family Peptidase_M42 PF05343.14 CRG92791.1 - 0.15 11.1 0.1 7.4 5.5 0.1 2.1 1 1 1 2 2 2 0 M42 glutamyl aminopeptidase R3H-assoc PF13902.6 CRG92792.1 - 3.8e-24 85.6 6.1 6.6e-24 84.8 6.1 1.4 1 0 0 1 1 1 1 R3H-associated N-terminal domain R3H PF01424.22 CRG92792.1 - 0.034 14.1 0.0 0.31 11.1 0.0 2.3 2 0 0 2 2 2 0 R3H domain LRS4 PF10422.9 CRG92793.1 - 0.13 11.8 0.0 0.13 11.8 0.0 2.3 3 0 0 3 3 3 0 Monopolin complex subunit LRS4 TGT PF01702.18 CRG92794.1 - 7.1e-137 456.3 0.0 1.1e-133 445.7 0.0 2.0 1 1 0 1 1 1 1 Queuine tRNA-ribosyltransferase AFG1_ATPase PF03969.16 CRG92795.1 - 5.8e-95 318.2 0.1 2.4e-90 303.0 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 CRG92795.1 - 0.00044 20.7 2.0 0.21 12.0 0.0 3.8 3 1 0 3 3 3 1 AAA ATPase domain AAA PF00004.29 CRG92795.1 - 0.001 19.5 0.0 0.0031 18.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 CRG92795.1 - 0.0012 18.8 0.0 2.1 8.2 0.1 2.5 2 1 0 2 2 2 2 Bacterial dnaA protein AAA_14 PF13173.6 CRG92795.1 - 0.009 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 CRG92795.1 - 0.03 14.6 2.3 0.11 12.8 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 CRG92795.1 - 0.077 13.0 0.0 0.34 10.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) DLIC PF05783.11 CRG92795.1 - 0.12 11.2 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) RNA_helicase PF00910.22 CRG92795.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.9 1 1 0 1 1 1 0 RNA helicase SH3_1 PF00018.28 CRG92796.1 - 1.8e-23 81.8 0.0 2.2e-10 40.0 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 CRG92796.1 - 1.8e-13 50.1 0.8 3.7e-06 26.7 0.1 2.8 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 CRG92796.1 - 3.4e-13 49.6 0.0 1.1e-12 47.9 0.0 2.0 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 CRG92796.1 - 2.6e-12 46.2 0.0 4.8e-08 32.6 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 CRG92796.1 - 6.7e-08 32.4 0.4 1.3e-07 31.4 0.4 1.5 1 0 0 1 1 1 1 PB1 domain SAC3_GANP PF03399.16 CRG92797.1 - 2.7e-25 89.3 2.5 2.8e-23 82.7 2.5 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 CRG92797.1 - 1.8e-05 24.7 0.0 3.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family EAP30 PF04157.16 CRG92798.1 - 2.8e-41 141.4 0.4 3.9e-41 140.9 0.4 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 CRG92798.1 - 8.9e-23 79.5 2.2 8.9e-23 79.5 2.2 2.4 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vps36_ESCRT-II PF11605.8 CRG92798.1 - 3.4e-22 78.4 0.0 6e-22 77.6 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-Sec23_Sec24 PF04810.15 CRG92798.1 - 0.00086 19.3 5.4 0.0054 16.8 0.5 2.4 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger DUF3646 PF12362.8 CRG92798.1 - 0.0063 16.8 0.0 0.034 14.5 0.0 2.2 2 0 0 2 2 2 1 DNA polymerase III gamma and tau subunits C terminal zf-RanBP PF00641.18 CRG92798.1 - 0.03 13.6 0.9 0.03 13.6 0.9 2.7 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others GRAM PF02893.20 CRG92798.1 - 0.033 14.1 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 GRAM domain EutK_C PF16365.5 CRG92798.1 - 0.036 14.1 1.1 0.085 12.9 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilization protein EutK C-terminus DZR PF12773.7 CRG92798.1 - 0.045 13.8 5.6 0.05 13.6 0.8 2.3 2 0 0 2 2 2 0 Double zinc ribbon Stc1 PF12898.7 CRG92798.1 - 0.18 12.4 0.4 0.5 11.0 0.4 1.7 1 0 0 1 1 1 0 Stc1 domain DJ-1_PfpI PF01965.24 CRG92799.1 - 5.3e-05 23.1 0.0 7.8e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family GGACT PF06094.12 CRG92800.1 - 2.8e-13 50.5 0.0 3.5e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Asp PF00026.23 CRG92801.1 - 7.4e-11 42.0 0.0 9.4e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease CRA PF06589.11 CRG92802.1 - 0.11 12.6 2.4 0.24 11.5 2.4 1.5 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Cwf_Cwc_15 PF04889.12 CRG92802.1 - 0.79 9.4 17.9 0.13 11.9 14.1 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Ycf1 PF05758.12 CRG92802.1 - 0.79 7.5 3.6 1.1 7.0 3.6 1.2 1 0 0 1 1 1 0 Ycf1 FAM76 PF16046.5 CRG92802.1 - 1.2 8.4 9.9 2.1 7.7 9.9 1.3 1 0 0 1 1 1 0 FAM76 protein DUF4794 PF16042.5 CRG92802.1 - 2.7 9.0 6.5 6.8 7.7 6.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4794) TPR_10 PF13374.6 CRG92803.1 - 7.2e-79 257.8 9.6 2.6e-13 49.3 0.0 7.9 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_12 PF13424.6 CRG92803.1 - 4.4e-61 203.1 28.5 3.8e-20 72.0 1.8 5.6 2 2 2 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 CRG92803.1 - 1.2e-36 123.0 32.5 7.8e-06 25.5 0.2 7.9 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 CRG92803.1 - 2.9e-32 108.3 10.0 6.6e-05 22.7 0.0 8.6 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 CRG92803.1 - 4.1e-27 92.1 22.5 0.0022 18.0 0.1 8.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_MalT PF17874.1 CRG92803.1 - 8.5e-27 94.4 6.6 3.4e-12 46.4 1.1 4.1 1 1 2 3 3 3 3 MalT-like TPR region TPR_14 PF13428.6 CRG92803.1 - 5.8e-24 82.7 7.3 0.045 14.6 0.0 8.9 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 CRG92803.1 - 1.4e-21 74.9 23.4 0.0031 17.6 0.2 8.1 7 0 0 7 7 7 6 Tetratricopeptide repeat PNP_UDP_1 PF01048.20 CRG92803.1 - 1.8e-14 53.5 0.0 3.8e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Phosphorylase superfamily TPR_16 PF13432.6 CRG92803.1 - 2e-13 50.7 15.7 0.0016 19.0 1.6 7.8 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 CRG92803.1 - 1.3e-12 47.2 10.3 2 9.0 0.1 8.6 9 0 0 9 9 7 3 Tetratricopeptide repeat NB-ARC PF00931.22 CRG92803.1 - 3.6e-12 46.0 0.0 5.6e-12 45.4 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 CRG92803.1 - 6.6e-09 36.4 0.0 2e-08 34.8 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain TPR_4 PF07721.14 CRG92803.1 - 7.8e-08 32.2 0.0 66 4.6 0.0 7.4 7 0 0 7 7 6 0 Tetratricopeptide repeat DUF2225 PF09986.9 CRG92803.1 - 3.6e-07 30.1 2.6 0.18 11.5 0.1 4.1 1 1 3 4 4 4 4 Uncharacterized protein conserved in bacteria (DUF2225) TPR_21 PF09976.9 CRG92803.1 - 4.6e-07 29.7 13.5 2.3 7.9 0.2 7.0 4 2 3 7 7 7 3 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 CRG92803.1 - 5.9e-07 29.6 2.8 0.18 12.1 0.1 4.9 2 2 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 CRG92803.1 - 1e-06 28.3 29.2 0.37 10.5 0.3 7.5 7 0 0 7 7 7 3 TPR repeat PPR PF01535.20 CRG92803.1 - 4.9e-05 23.3 4.9 5.3 7.5 0.0 6.4 6 0 0 6 6 6 1 PPR repeat MIT PF04212.18 CRG92803.1 - 0.00034 20.6 10.0 2.5 8.2 0.1 5.7 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 CRG92803.1 - 0.00053 19.7 4.0 0.066 12.9 0.7 4.5 1 1 0 3 3 3 1 26S proteasome subunit RPN7 SNAP PF14938.6 CRG92803.1 - 0.0015 18.0 0.3 0.31 10.4 0.0 2.6 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 CRG92803.1 - 0.0016 18.9 19.8 0.23 12.0 2.0 5.8 3 1 3 6 6 5 4 Tetratricopeptide repeat NACHT PF05729.12 CRG92803.1 - 0.0027 17.7 0.0 0.0054 16.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TPR_3 PF07720.12 CRG92803.1 - 0.0062 16.5 13.1 0.29 11.2 0.2 6.5 7 0 0 7 7 7 1 Tetratricopeptide repeat DUF5344 PF17279.2 CRG92803.1 - 0.0086 16.6 0.4 34 5.1 0.0 4.6 2 2 2 4 4 4 0 Family of unknown function (DUF5344) TPR_6 PF13174.6 CRG92803.1 - 0.024 15.3 28.5 15 6.5 0.1 8.1 8 0 0 8 8 7 0 Tetratricopeptide repeat RPN6_N PF18055.1 CRG92803.1 - 0.066 13.6 3.2 7.2 7.0 0.1 3.8 2 1 2 4 4 4 0 26S proteasome regulatory subunit RPN6 N-terminal domain AAA_22 PF13401.6 CRG92803.1 - 0.07 13.4 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain zf-RVT PF13966.6 CRG92803.1 - 0.12 13.1 0.1 0.35 11.6 0.1 1.7 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase OEP PF02321.18 CRG92803.1 - 0.69 9.7 4.8 4.4 7.1 0.8 3.4 3 0 0 3 3 3 0 Outer membrane efflux protein DUF4810 PF16068.5 CRG92803.1 - 0.79 10.3 11.0 38 4.9 0.1 6.1 6 0 0 6 6 6 0 Domain of unknown function (DUF4810) RSN1_7TM PF02714.15 CRG92805.1 - 1.8e-69 234.1 17.2 3.2e-69 233.3 17.2 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CRG92805.1 - 3e-30 105.1 0.4 3e-30 105.1 0.4 2.8 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CRG92805.1 - 5.2e-09 36.6 0.0 7.9e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Anoctamin PF04547.12 CRG92805.1 - 0.017 14.0 4.0 0.027 13.3 1.8 2.2 1 1 1 2 2 2 0 Calcium-activated chloride channel HlyIII PF03006.20 CRG92806.1 - 1.2e-14 54.5 15.6 1.7e-14 54.1 15.6 1.2 1 0 0 1 1 1 1 Haemolysin-III related DUF2207 PF09972.9 CRG92807.1 - 0.042 12.6 0.0 0.057 12.2 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MGC-24 PF05283.11 CRG92807.1 - 3.5 8.1 18.5 1.1 9.7 6.8 2.7 1 1 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin CALCOCO1 PF07888.11 CRG92808.1 - 0.00074 18.5 0.1 0.00091 18.2 0.1 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like FAM76 PF16046.5 CRG92808.1 - 0.033 13.5 0.4 0.039 13.3 0.4 1.1 1 0 0 1 1 1 0 FAM76 protein IFT20 PF14931.6 CRG92808.1 - 0.22 11.7 1.7 0.28 11.4 0.9 1.5 1 1 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Myb_DNA-bind_5 PF13873.6 CRG92809.1 - 1.8e-05 24.7 0.2 2.5e-05 24.3 0.2 1.2 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain HMG_box PF00505.19 CRG92810.1 - 2.7e-10 40.5 0.4 5.9e-10 39.4 0.4 1.6 1 0 0 1 1 1 1 HMG (high mobility group) box DnaJ PF00226.31 CRG92811.1 - 6.8e-10 38.9 0.2 6.8e-10 38.9 0.2 1.9 2 0 0 2 2 2 1 DnaJ domain NAD_binding_6 PF08030.12 CRG92811.1 - 3.8e-09 36.8 0.4 1.1e-08 35.4 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 CRG92811.1 - 3.9e-08 33.3 0.0 1e-07 32.0 0.0 1.7 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 CRG92811.1 - 8.3e-06 25.9 8.6 1.1e-05 25.5 7.2 2.0 1 1 1 2 2 2 1 Ferric reductase like transmembrane component Seryl_tRNA_N PF02403.22 CRG92812.1 - 6.8e-05 23.1 15.9 0.014 15.6 5.8 2.4 1 1 1 2 2 2 2 Seryl-tRNA synthetase N-terminal domain betaPIX_CC PF16523.5 CRG92812.1 - 0.00057 19.7 3.5 0.00057 19.7 3.5 2.2 1 1 1 2 2 2 1 betaPIX coiled coil Filament PF00038.21 CRG92812.1 - 0.0043 16.7 21.8 0.012 15.2 8.0 2.1 1 1 1 2 2 2 2 Intermediate filament protein Lebercilin PF15619.6 CRG92812.1 - 0.013 15.1 17.7 0.017 14.8 17.7 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF2540 PF10802.8 CRG92812.1 - 0.035 14.2 1.6 0.043 13.9 0.4 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2540) FliD_N PF02465.18 CRG92812.1 - 0.093 13.4 6.7 0.12 13.1 0.8 2.2 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF677 PF05055.12 CRG92812.1 - 0.1 11.5 9.8 0.089 11.7 4.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF677) GAS PF13851.6 CRG92812.1 - 0.12 11.7 22.7 0.17 11.2 3.9 2.8 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 CRG92812.1 - 0.13 12.5 11.8 0.3 11.4 1.3 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein TMF_TATA_bd PF12325.8 CRG92812.1 - 0.14 12.3 18.0 0.24 11.6 7.0 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Bacillus_HBL PF05791.11 CRG92812.1 - 0.15 11.9 9.0 0.15 11.9 1.7 2.1 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Phage_GPO PF05929.11 CRG92812.1 - 0.2 11.3 8.6 0.25 10.9 8.6 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase MCPsignal PF00015.21 CRG92812.1 - 0.24 11.2 6.1 1.1 9.0 0.9 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Spc7 PF08317.11 CRG92812.1 - 0.24 10.3 22.5 0.21 10.4 8.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 CRG92812.1 - 0.28 10.2 16.6 0.59 9.2 16.6 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Paralemmin PF03285.15 CRG92812.1 - 0.33 10.5 13.3 0.74 9.3 5.3 2.1 2 0 0 2 2 2 0 Paralemmin ATG16 PF08614.11 CRG92812.1 - 0.42 10.8 20.2 0.25 11.5 17.3 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 CRG92812.1 - 0.5 10.4 19.7 0.4 10.8 6.0 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Vps53_N PF04100.12 CRG92812.1 - 0.61 9.0 13.4 0.27 10.1 3.1 2.1 1 1 1 2 2 2 0 Vps53-like, N-terminal DUF1677 PF07911.13 CRG92812.1 - 0.62 10.5 4.9 1.1 9.6 0.5 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1677) BLOC1_2 PF10046.9 CRG92812.1 - 0.62 10.4 14.4 0.63 10.4 4.3 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.8 CRG92812.1 - 0.65 9.3 17.5 0.39 10.0 4.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) MYO10_CC PF16735.5 CRG92812.1 - 0.79 9.9 17.9 0.13 12.4 2.3 3.3 2 2 1 3 3 3 0 Unconventional myosin-X coiled coil domain Exonuc_VII_L PF02601.15 CRG92812.1 - 0.94 9.0 10.8 1.3 8.5 10.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5069 PF16798.5 CRG92812.1 - 1 9.5 6.2 0.4 10.9 0.6 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF5069) ADIP PF11559.8 CRG92812.1 - 1.3 9.1 22.0 0.78 9.8 5.6 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Trimer_CC PF08954.11 CRG92812.1 - 1.7 8.3 9.8 3.9 7.1 1.1 2.7 3 0 0 3 3 2 0 Trimerisation motif DUF3573 PF12097.8 CRG92812.1 - 1.8 7.3 7.3 0.42 9.4 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) LMBR1 PF04791.16 CRG92812.1 - 1.8 7.4 9.9 2.1 7.2 9.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein APG6_N PF17675.1 CRG92812.1 - 1.9 9.0 20.7 1.4 9.5 10.3 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 CRG92812.1 - 3 7.1 15.3 12 5.2 15.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 CRG92812.1 - 3.8 6.7 15.3 0.49 9.6 3.4 2.0 1 1 1 2 2 2 0 TMPIT-like protein GvpL_GvpF PF06386.11 CRG92812.1 - 4.2 7.2 10.8 0.9 9.4 3.4 2.1 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Laminin_II PF06009.12 CRG92812.1 - 4.4 7.3 12.6 5.1 7.1 3.2 2.2 1 1 1 2 2 2 0 Laminin Domain II zf-C4H2 PF10146.9 CRG92812.1 - 4.7 7.5 17.8 1.6 9.0 2.4 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein HalX PF08663.10 CRG92812.1 - 5 7.5 11.3 8.8 6.7 0.9 3.2 2 1 1 3 3 3 0 HalX domain DUF484 PF04340.12 CRG92812.1 - 5.4 6.6 10.5 2.3 7.9 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF484 Jnk-SapK_ap_N PF09744.9 CRG92812.1 - 5.4 7.2 22.0 24 5.1 15.4 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 YabA PF06156.13 CRG92812.1 - 8 7.2 11.3 5.5 7.7 0.9 2.2 2 0 0 2 2 2 0 Initiation control protein YabA DUF1664 PF07889.12 CRG92812.1 - 9.9 6.2 13.9 9.1 6.3 3.2 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) WD40 PF00400.32 CRG92815.1 - 1.7e-27 95.1 16.3 0.00037 21.3 0.0 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 CRG92815.1 - 9.3e-06 25.9 0.3 3.3 8.1 0.0 3.5 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 CRG92815.1 - 0.0001 21.4 0.1 0.068 12.1 0.0 2.7 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 CRG92815.1 - 0.0003 20.2 0.1 0.3 10.4 0.0 3.2 2 2 1 3 3 3 2 WD40-like domain eIF2A PF08662.11 CRG92815.1 - 0.007 16.3 0.0 0.088 12.7 0.0 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A ChapFlgA PF13144.6 CRG92815.1 - 0.037 14.1 0.0 0.4 10.7 0.0 2.4 3 0 0 3 3 3 0 Chaperone for flagella basal body P-ring formation Nup160 PF11715.8 CRG92815.1 - 0.35 9.5 3.6 7.6 5.0 0.0 3.4 3 1 1 4 4 4 0 Nucleoporin Nup120/160 Fungal_trans PF04082.18 CRG92817.1 - 0.00067 18.8 0.0 0.0014 17.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain RadC PF04002.15 CRG92818.1 - 0.0047 16.9 0.1 0.012 15.6 0.1 1.7 1 0 0 1 1 1 1 RadC-like JAB domain NPV_P10 PF05531.12 CRG92818.1 - 0.033 14.6 3.5 0.14 12.7 0.2 2.8 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein zf-RVT PF13966.6 CRG92818.1 - 0.12 13.1 0.0 0.51 11.1 0.0 2.0 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase Helitron_like_N PF14214.6 CRG92819.1 - 3.4e-11 43.7 0.0 5.3e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 Helitron helicase-like domain at N-terminus RNA_pol_Rpc34 PF05158.12 CRG92820.1 - 0.13 11.6 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit adh_short PF00106.25 CRG92821.1 - 5e-38 130.5 0.9 6.2e-38 130.2 0.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92821.1 - 5.9e-37 127.5 0.0 9.3e-37 126.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92821.1 - 4.5e-10 39.7 0.2 7.9e-10 38.9 0.2 1.3 1 0 0 1 1 1 1 KR domain Glu_dehyd_C PF16912.5 CRG92821.1 - 0.00024 20.7 0.1 0.00033 20.2 0.1 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Polysacc_synt_2 PF02719.15 CRG92821.1 - 0.0013 17.9 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 CRG92821.1 - 0.0083 15.2 0.1 0.012 14.6 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 CRG92821.1 - 0.018 14.5 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Dynamin_M PF01031.20 CRG92822.1 - 6.6e-51 173.2 0.0 9.6e-51 172.7 0.0 1.2 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 CRG92822.1 - 7.1e-29 101.0 0.0 1.4e-28 100.0 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 CRG92822.1 - 1.3e-06 28.4 0.1 5.3e-05 23.3 0.1 2.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 CRG92822.1 - 0.00083 18.9 0.0 0.83 9.2 0.0 2.4 2 0 0 2 2 2 2 Ferrous iron transport protein B Roc PF08477.13 CRG92822.1 - 0.014 15.7 0.1 0.55 10.5 0.0 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 CRG92822.1 - 0.024 14.4 0.0 0.074 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system GED PF02212.18 CRG92822.1 - 0.061 13.5 0.0 0.2 11.8 0.0 2.0 1 0 0 1 1 1 0 Dynamin GTPase effector domain ABC_tran PF00005.27 CRG92824.1 - 5.3e-30 104.7 0.0 9.8e-30 103.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 CRG92824.1 - 6.3e-07 29.1 0.0 2.8e-06 26.9 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 CRG92824.1 - 6.8e-05 22.7 0.2 0.0001 22.1 0.2 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Zeta_toxin PF06414.12 CRG92824.1 - 0.0012 18.1 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 CRG92824.1 - 0.0016 18.7 0.1 0.0071 16.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 CRG92824.1 - 0.0089 16.1 0.1 0.026 14.6 0.1 1.7 1 0 0 1 1 1 1 Helicase HerA, central domain APS_kinase PF01583.20 CRG92824.1 - 0.012 15.5 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase G-alpha PF00503.20 CRG92824.1 - 0.02 14.0 0.0 0.041 13.1 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit AAA_29 PF13555.6 CRG92824.1 - 0.032 14.0 0.0 0.074 12.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 CRG92824.1 - 0.042 13.7 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 CRG92824.1 - 0.047 14.1 0.0 0.088 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_21 PF13304.6 CRG92824.1 - 0.092 12.5 0.0 0.43 10.3 0.0 2.0 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 CRG92824.1 - 0.16 12.6 0.0 0.34 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 CRG92824.1 - 0.26 11.8 1.4 0.41 11.1 0.4 1.7 1 1 0 1 1 1 0 AAA domain Zn_Tnp_IS1595 PF12760.7 CRG92826.1 - 0.072 13.1 1.3 0.2 11.7 1.3 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Phage_GPO PF05929.11 CRG92826.1 - 0.82 9.2 3.8 0.18 11.4 0.4 1.5 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase PNP_UDP_1 PF01048.20 CRG92827.1 - 4.5e-16 58.8 0.1 2e-15 56.7 0.1 2.1 1 1 0 1 1 1 1 Phosphorylase superfamily NB-ARC PF00931.22 CRG92827.1 - 0.00015 21.1 0.0 0.00029 20.1 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 CRG92827.1 - 0.0048 17.3 0.2 0.024 15.0 0.2 2.2 1 1 0 1 1 1 1 AAA ATPase domain Sfi1 PF08457.10 CRG92827.1 - 0.16 10.5 0.5 0.27 9.7 0.0 1.5 2 0 0 2 2 2 0 Sfi1 spindle body protein DDE_3 PF13358.6 CRG92828.1 - 3.9e-32 111.0 0.0 6.5e-32 110.3 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_33 PF13592.6 CRG92828.1 - 9.8e-06 25.1 0.1 3.3e-05 23.5 0.1 1.9 1 0 0 1 1 1 1 Winged helix-turn helix rve PF00665.26 CRG92828.1 - 1.4e-05 25.3 0.0 3.8e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain DDE_1 PF03184.19 CRG92828.1 - 7.7e-05 22.4 0.0 0.00014 21.6 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_32 PF13565.6 CRG92828.1 - 0.0054 17.3 0.0 0.017 15.7 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain DDE_Tnp_ISAZ013 PF07592.11 CRG92828.1 - 0.043 12.8 0.1 0.26 10.2 0.0 1.9 2 0 0 2 2 2 0 Rhodopirellula transposase DDE domain DNA_pol3_theta PF06440.11 CRG92828.1 - 0.082 12.6 0.6 0.21 11.3 0.6 1.6 1 0 0 1 1 1 0 DNA polymerase III, theta subunit Cbl_N PF02262.16 CRG92828.1 - 0.12 12.3 0.0 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 HTH_23 PF13384.6 CRG92828.1 - 0.42 10.5 2.4 5.3 7.0 0.0 3.0 3 0 0 3 3 3 0 Homeodomain-like domain Na_Ca_ex PF01699.24 CRG92829.1 - 3.1e-06 27.2 21.9 4.3e-05 23.5 2.1 2.5 2 1 0 2 2 2 2 Sodium/calcium exchanger protein RVP PF00077.20 CRG92831.1 - 0.05 13.9 0.0 0.083 13.2 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease ABC_tran PF00005.27 CRG92833.1 - 2.6e-32 112.2 0.0 1.7e-31 109.5 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CRG92833.1 - 1.3e-16 61.1 3.9 1.7e-16 60.7 3.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CRG92833.1 - 1.4e-06 27.9 0.3 5.7e-05 22.7 0.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 CRG92833.1 - 0.0015 18.5 0.0 0.0033 17.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 CRG92833.1 - 0.011 15.5 0.4 0.14 11.9 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 CRG92833.1 - 0.016 15.6 0.0 0.042 14.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CRG92833.1 - 0.024 14.9 0.0 0.11 12.8 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 CRG92833.1 - 0.065 12.9 0.2 0.25 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 CRG92833.1 - 0.15 11.4 0.0 0.3 10.4 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Metallophos PF00149.28 CRG92836.1 - 5.4e-14 53.2 0.6 8.8e-14 52.5 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 CRG92836.1 - 0.00026 21.2 0.2 0.0014 18.9 0.1 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain TPR_12 PF13424.6 CRG92837.1 - 0.00055 20.2 0.1 0.014 15.7 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 CRG92837.1 - 0.00076 19.3 0.6 0.0026 17.6 0.6 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_4 PF07721.14 CRG92837.1 - 0.0067 16.9 0.0 0.02 15.5 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat RasGEF PF00617.19 CRG92840.1 - 1.3e-06 28.7 0.0 5.2e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 RasGEF domain AAA PF00004.29 CRG92841.1 - 7.2e-24 84.7 0.0 2e-22 80.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 CRG92841.1 - 5.4e-05 23.6 1.9 0.0016 18.9 0.7 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 CRG92841.1 - 0.00063 20.0 2.1 0.04 14.2 0.0 2.9 2 2 1 3 3 3 1 AAA domain RuvB_N PF05496.12 CRG92841.1 - 0.0014 18.4 0.0 0.0029 17.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 CRG92841.1 - 0.0016 18.6 0.0 0.0034 17.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 CRG92841.1 - 0.011 16.3 0.0 0.029 14.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 CRG92841.1 - 0.017 15.1 0.0 0.034 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 CRG92841.1 - 0.018 15.4 0.0 0.044 14.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 CRG92841.1 - 0.026 14.7 0.0 0.083 13.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 CRG92841.1 - 0.041 14.3 0.0 0.11 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 CRG92841.1 - 0.17 11.3 0.0 0.47 9.8 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF2205 PF10224.9 CRG92843.1 - 0.016 15.2 3.9 0.025 14.6 3.9 1.3 1 0 0 1 1 1 0 Short coiled-coil protein APG6_N PF17675.1 CRG92843.1 - 0.019 15.5 7.5 0.022 15.3 7.5 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DivIC PF04977.15 CRG92843.1 - 0.032 14.0 2.5 0.036 13.8 1.7 1.5 1 1 0 1 1 1 0 Septum formation initiator TSC22 PF01166.18 CRG92843.1 - 0.066 13.5 1.0 0.12 12.7 1.0 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family MIF4G_like_2 PF09090.11 CRG92843.1 - 0.083 12.3 3.4 0.086 12.3 3.4 1.0 1 0 0 1 1 1 0 MIF4G like ZapB PF06005.12 CRG92843.1 - 0.11 13.0 8.0 0.18 12.3 8.0 1.5 1 0 0 1 1 1 0 Cell division protein ZapB Swi5 PF07061.11 CRG92843.1 - 0.12 12.5 2.3 0.21 11.7 2.3 1.4 1 0 0 1 1 1 0 Swi5 DUF5446 PF17522.2 CRG92843.1 - 0.19 11.9 3.4 0.37 11.0 1.8 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5446) V_ATPase_I PF01496.19 CRG92843.1 - 0.25 9.2 1.9 0.24 9.3 1.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.9 CRG92843.1 - 0.29 11.3 9.5 0.34 11.1 9.5 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 JIP_LZII PF16471.5 CRG92843.1 - 0.85 9.8 7.0 0.089 13.0 2.2 1.9 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Pkinase_Tyr PF07714.17 CRG92844.1 - 5.1e-15 55.5 0.0 4e-13 49.2 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 CRG92844.1 - 3.7e-11 42.9 0.0 1.4e-10 41.0 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain FTA2 PF13095.6 CRG92844.1 - 0.061 12.9 0.0 0.12 12.0 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 CRG92844.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LRR_3 PF07725.12 CRG92844.1 - 0.15 11.9 0.1 0.98 9.4 0.0 2.2 2 0 0 2 2 2 0 Leucine Rich Repeat RVT_2 PF07727.14 CRG92846.1 - 1e-73 248.0 0.0 1.5e-73 247.4 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CRG92846.1 - 7e-09 35.9 0.0 1.7e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CRG92846.1 - 4.6e-06 26.4 0.3 1.2e-05 25.0 0.3 1.7 1 0 0 1 1 1 1 GAG-pre-integrase domain Vel1p PF10339.9 CRG92846.1 - 0.14 11.5 0.1 0.29 10.5 0.1 1.4 1 0 0 1 1 1 0 Yeast-specific zinc responsive zf-C2H2_10 PF16588.5 CRG92846.1 - 1.7 8.5 6.1 0.42 10.4 1.6 2.2 2 0 0 2 2 2 0 C2H2 zinc-finger BCS1_N PF08740.11 CRG92848.1 - 1.1e-33 116.8 0.0 1.9e-33 116.1 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 CRG92848.1 - 8.3e-17 61.8 0.0 1.8e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 CRG92848.1 - 0.0041 16.9 0.0 0.0078 16.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Spec3 PF15795.5 CRG92848.1 - 0.16 12.5 0.2 0.3 11.6 0.2 1.4 1 0 0 1 1 1 0 Ectodermal ciliogenesis protein DUF3439 PF11921.8 CRG92849.1 - 0.0023 17.9 2.2 0.0044 17.0 2.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) BPS1 PF05633.11 CRG92849.1 - 0.17 10.8 0.1 0.38 9.7 0.1 1.4 1 1 0 1 1 1 0 Protein BYPASS1-related DUF3560 PF12083.8 CRG92851.1 - 3 8.0 6.2 1.4 9.1 3.2 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3560) TT_ORF2 PF02957.15 CRG92851.1 - 4 8.4 6.2 0.36 11.7 1.1 1.8 2 0 0 2 2 2 0 TT viral ORF2 zf-C2H2 PF00096.26 CRG92852.1 - 0.011 16.2 4.4 0.08 13.4 0.1 3.2 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG92852.1 - 0.056 14.3 8.3 0.15 13.0 0.1 3.7 3 0 0 3 3 3 0 C2H2-type zinc finger Metallophos PF00149.28 CRG92853.1 - 8.2e-08 33.0 1.6 1.1e-07 32.5 1.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AbiEii PF08843.11 CRG92854.1 - 0.0012 18.9 0.0 0.0015 18.5 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system Cmc1 PF08583.10 CRG92855.1 - 0.046 13.7 0.1 0.13 12.3 0.1 1.7 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Adeno_E3_CR1 PF02440.15 CRG92857.1 - 0.025 14.4 0.2 0.059 13.2 0.2 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 Mo-co_dimer PF03404.16 CRG92857.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Mur_ligase_M PF08245.12 CRG92858.1 - 1.7e-06 28.2 0.0 6.7e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Mur ligase middle domain TPR_12 PF13424.6 CRG92858.1 - 2.6e-05 24.4 1.6 0.12 12.7 0.5 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat JmjC PF02373.22 CRG92858.1 - 8.4e-05 23.0 0.0 0.0074 16.7 0.0 2.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 CRG92858.1 - 0.0018 17.8 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 Cupin superfamily protein TPR_16 PF13432.6 CRG92858.1 - 0.21 12.3 1.8 1.5 9.5 0.5 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4315 PF14193.6 CRG92859.1 - 1.3 9.1 9.2 3.6 7.7 9.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) KfrA_N PF11740.8 CRG92859.1 - 4.2 8.1 7.1 72 4.1 8.3 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Peptidase_C48 PF02902.19 CRG92861.1 - 1.6e-07 31.4 0.0 3.6e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Na_Ca_ex PF01699.24 CRG92862.1 - 3.7e-16 59.4 19.3 2.8e-09 37.1 7.1 2.7 2 1 1 3 3 3 2 Sodium/calcium exchanger protein MFS_1 PF07690.16 CRG92865.1 - 6.8e-40 137.1 48.8 6.8e-40 137.1 48.8 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 CRG92865.1 - 4.2e-08 32.1 28.1 6.1e-07 28.2 28.1 2.0 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 CRG92865.1 - 6.4e-05 22.0 16.9 6.4e-05 22.0 16.9 2.8 2 0 0 2 2 2 2 Sugar (and other) transporter KR PF08659.10 CRG92866.1 - 1.9e-31 109.4 0.1 2.8e-30 105.6 0.0 2.2 2 0 0 2 2 2 1 KR domain MFS_1 PF07690.16 CRG92866.1 - 1.5e-21 76.7 41.5 2.5e-21 76.0 41.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily ADH_zinc_N PF00107.26 CRG92866.1 - 3e-12 46.6 0.0 4.9e-11 42.7 0.0 2.4 2 0 0 2 2 2 1 Zinc-binding dehydrogenase adh_short PF00106.25 CRG92866.1 - 2.9e-05 23.6 0.0 0.007 15.8 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92866.1 - 0.00024 20.7 0.0 0.00059 19.5 0.0 1.6 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 CRG92866.1 - 0.11 12.4 0.0 1.8 8.4 0.0 2.2 2 0 0 2 2 2 0 NAD(P)H-binding Bac_rhamnosid_C PF17390.2 CRG92867.1 - 2.3e-09 36.9 0.0 4.4e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain DUF443 PF04276.12 CRG92867.1 - 0.064 13.1 0.1 0.16 11.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF443) Lipase_2 PF01674.18 CRG92868.1 - 2.5e-06 27.2 0.0 2.6e-05 23.9 0.0 2.2 3 0 0 3 3 3 1 Lipase (class 2) Abhydrolase_6 PF12697.7 CRG92868.1 - 0.0012 19.5 0.2 0.0016 19.1 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 CRG92868.1 - 0.0063 15.8 0.0 0.0087 15.3 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 CRG92868.1 - 0.075 12.6 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) adh_short PF00106.25 CRG92869.1 - 2.2e-26 92.5 0.8 5.8e-25 87.9 0.8 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 CRG92869.1 - 2.1e-18 66.7 0.9 2.8e-17 63.1 0.9 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 CRG92869.1 - 3.7e-06 27.0 0.1 5.9e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 CRG92869.1 - 0.0038 17.2 0.2 0.0061 16.5 0.2 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Eno-Rase_NADH_b PF12242.8 CRG92869.1 - 0.0065 16.2 0.7 4.2 7.2 0.0 2.6 2 0 0 2 2 2 2 NAD(P)H binding domain of trans-2-enoyl-CoA reductase AMP-binding PF00501.28 CRG92870.1 - 4e-05 22.4 0.1 7.1e-05 21.6 0.1 1.4 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 CRG92870.1 - 0.1 13.6 0.0 0.65 11.0 0.0 2.2 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Ank_2 PF12796.7 CRG92871.1 - 1.9e-12 47.6 0.0 2.2e-10 41.0 0.0 2.6 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 CRG92871.1 - 1.3e-08 34.9 0.1 0.045 14.2 0.0 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 CRG92871.1 - 1.3e-07 31.3 0.0 0.21 12.3 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 CRG92871.1 - 1.4e-07 31.9 0.0 0.011 16.3 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 CRG92871.1 - 1.7e-06 28.2 0.0 0.088 13.2 0.0 3.3 2 1 0 2 2 2 2 Ankyrin repeats (many copies) DUF2095 PF09868.9 CRG92871.1 - 0.073 13.1 0.0 0.55 10.2 0.0 2.2 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2095) BUD22 PF09073.10 CRG92872.1 - 8.8 5.5 10.4 11 5.2 10.4 1.0 1 0 0 1 1 1 0 BUD22 SdiA-regulated PF06977.11 CRG92874.1 - 0.11 11.7 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 SdiA-regulated Ank_2 PF12796.7 CRG92878.1 - 2.5e-23 82.5 1.2 6.6e-14 52.3 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG92878.1 - 7.1e-23 80.7 3.6 2.5e-10 40.7 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG92878.1 - 9.5e-21 71.7 1.0 7.8e-06 25.9 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 CRG92878.1 - 7.3e-19 67.3 2.5 1.3e-07 31.7 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 CRG92878.1 - 1.2e-11 44.6 2.9 0.012 15.9 0.1 4.2 3 2 1 5 5 5 3 Ankyrin repeats (many copies) CdvA PF18822.1 CRG92880.1 - 0.014 15.2 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Apolipoprotein PF01442.18 CRG92880.1 - 0.021 14.7 0.3 0.035 14.0 0.3 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Tmemb_cc2 PF10267.9 CRG92880.1 - 0.035 13.2 0.4 0.039 13.1 0.4 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein EMP24_GP25L PF01105.24 CRG92880.1 - 0.063 13.2 0.3 0.073 13.0 0.3 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF148 PF02520.17 CRG92880.1 - 0.084 13.0 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF148 Pheromone PF08015.11 CRG92880.1 - 0.76 10.9 3.5 1.1 10.3 3.5 1.2 1 0 0 1 1 1 0 Fungal mating-type pheromone Methyltransf_25 PF13649.6 CRG92885.1 - 2.2e-07 31.5 0.0 5.8e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 CRG92885.1 - 7.5e-06 25.9 0.0 1.3e-05 25.1 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 CRG92885.1 - 3.6e-05 24.3 0.0 7.8e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92885.1 - 5.3e-05 23.1 0.1 0.00013 21.8 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 CRG92885.1 - 0.0076 17.0 0.0 0.021 15.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 CRG92885.1 - 0.011 15.3 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 CRG92885.1 - 0.011 15.1 0.0 0.046 13.0 0.0 1.8 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family MetW PF07021.12 CRG92885.1 - 0.093 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PDZ_1 PF12812.7 CRG92886.1 - 2.8e-27 94.5 0.3 5.9e-18 64.7 0.0 2.7 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 CRG92886.1 - 2.1e-21 77.4 0.1 1.1e-16 62.1 0.0 2.9 3 0 0 3 3 3 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 CRG92886.1 - 1.4e-12 47.3 4.7 3.3e-08 33.2 0.1 4.4 4 1 1 5 5 5 3 PDZ domain PDZ_2 PF13180.6 CRG92886.1 - 2.4e-12 47.0 2.2 0.00012 22.4 0.0 4.4 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 CRG92886.1 - 4.5e-06 26.9 0.0 0.047 14.0 0.0 3.7 3 0 0 3 3 3 1 PDZ domain DUF31 PF01732.16 CRG92886.1 - 0.00043 19.9 0.7 0.0007 19.2 0.7 1.3 1 0 0 1 1 1 1 Putative peptidase (DUF31) Peptidase_S7 PF00949.21 CRG92886.1 - 0.00048 19.9 4.0 0.0008 19.2 1.1 2.4 2 0 0 2 2 2 1 Peptidase S7, Flavivirus NS3 serine protease Trypsin PF00089.26 CRG92886.1 - 0.00069 19.5 0.0 0.0071 16.2 0.0 2.4 2 0 0 2 2 2 1 Trypsin Tricorn_PDZ PF14685.6 CRG92886.1 - 0.0011 18.9 0.3 0.24 11.4 0.1 3.1 2 0 0 2 2 2 1 Tricorn protease PDZ domain Peptidase_S29 PF02907.15 CRG92886.1 - 0.025 14.3 0.4 0.096 12.4 0.2 2.0 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.9 CRG92886.1 - 0.1 11.2 0.2 0.17 10.5 0.2 1.2 1 0 0 1 1 1 0 Peptidase S46 Peptidase_S3 PF00944.19 CRG92886.1 - 0.12 12.1 0.2 0.28 11.0 0.2 1.5 1 0 0 1 1 1 0 Alphavirus core protein CENP-B_N PF04218.13 CRG92888.1 - 1.3e-07 31.1 0.8 5.4e-07 29.1 0.4 2.0 1 1 1 2 2 2 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_Tc5 PF03221.16 CRG92888.1 - 8.1e-07 29.0 0.1 1.5e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_38 PF13936.6 CRG92888.1 - 4.5e-06 26.3 0.4 6.9e-06 25.7 0.4 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_4 PF13613.6 CRG92888.1 - 0.00047 19.8 0.0 0.0008 19.1 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix of DDE superfamily endonuclease Sigma70_r4 PF04545.16 CRG92888.1 - 0.00058 19.3 0.1 0.00099 18.6 0.1 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 MarR_2 PF12802.7 CRG92888.1 - 0.0052 16.6 0.0 0.0084 16.0 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_23 PF13384.6 CRG92888.1 - 0.007 16.1 0.1 0.018 14.9 0.0 1.7 1 1 0 1 1 1 1 Homeodomain-like domain MarR PF01047.22 CRG92888.1 - 0.017 15.0 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.6 CRG92888.1 - 0.02 15.0 0.0 0.045 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 CRG92888.1 - 0.042 13.8 0.0 0.079 12.9 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain PAX PF00292.18 CRG92888.1 - 0.085 12.8 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 'Paired box' domain Cas9_a PF18470.1 CRG92888.1 - 0.11 12.0 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 Cas9 alpha-helical lobe domain DUF2841 PF11001.8 CRG92889.1 - 2.4e-45 153.6 0.1 4e-45 152.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) zf-RVT PF13966.6 CRG92890.1 - 0.03 15.0 0.1 0.091 13.5 0.1 1.8 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase RVT_1 PF00078.27 CRG92890.1 - 0.06 12.8 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Orn_Arg_deC_N PF02784.16 CRG92891.1 - 1.4e-35 122.8 0.0 1.8e-35 122.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 CRG92891.1 - 1.6e-08 34.7 0.0 2.6e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DUF3723 PF12520.8 CRG92893.1 - 6.7e-68 229.6 0.1 3.9e-62 210.6 0.1 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF3723) Polysacc_deac_3 PF15421.6 CRG92893.1 - 0.21 10.0 0.0 0.34 9.4 0.0 1.2 1 0 0 1 1 1 0 Putative polysaccharide deacetylase Patatin PF01734.22 CRG92894.1 - 2e-08 34.7 0.1 5.6e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 Patatin-like phospholipase zf-C3HC4_3 PF13920.6 CRG92894.1 - 0.00032 20.5 4.9 0.00086 19.1 4.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 CRG92894.1 - 0.02 14.7 1.1 0.055 13.3 1.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 CRG92894.1 - 0.056 13.3 4.7 0.2 11.6 4.7 2.0 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 CRG92894.1 - 2.6 8.4 7.8 7.4 7.0 7.8 1.8 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 CRG92894.1 - 3.5 7.7 6.2 11 6.1 6.2 1.9 1 0 0 1 1 1 0 zinc-RING finger domain RSN1_7TM PF02714.15 CRG92895.1 - 3.1e-69 233.3 16.1 4.9e-69 232.7 16.1 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 CRG92895.1 - 4.3e-29 101.3 0.2 4.3e-29 101.3 0.2 2.3 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 CRG92895.1 - 4e-10 40.2 0.0 5.9e-10 39.7 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Glyco_hydro_18 PF00704.28 CRG92897.1 - 3.6e-10 40.1 0.3 1.6e-09 37.9 0.3 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Asp PF00026.23 CRG92898.1 - 2.1e-22 80.0 2.0 2.7e-22 79.6 2.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 CRG92898.1 - 0.00066 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal SRF-TF PF00319.18 CRG92900.1 - 0.00017 21.0 0.0 0.00099 18.5 0.0 2.2 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Lactamase_B_4 PF13691.6 CRG92900.1 - 0.099 12.3 0.0 0.71 9.6 0.0 2.3 1 1 1 2 2 2 0 tRNase Z endonuclease DUF936 PF06075.12 CRG92902.1 - 0.012 14.6 3.7 0.015 14.3 3.7 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Herpes_DNAp_acc PF04929.12 CRG92902.1 - 3.5 6.5 5.2 5 6.0 5.2 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor GAS PF13851.6 CRG92905.1 - 0.0068 15.8 0.9 0.008 15.5 0.9 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CRG92905.1 - 0.011 14.7 1.2 0.013 14.4 1.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FmiP_Thoc5 PF09766.9 CRG92905.1 - 0.016 14.6 0.4 0.018 14.4 0.4 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 FlaC_arch PF05377.11 CRG92905.1 - 0.021 15.2 1.2 0.043 14.2 0.3 1.9 1 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Comm PF15957.5 CRG92905.1 - 0.023 15.0 0.1 0.028 14.8 0.1 1.3 1 1 0 1 1 1 0 Commissureless Filament PF00038.21 CRG92905.1 - 0.035 13.7 1.8 0.042 13.4 1.8 1.1 1 0 0 1 1 1 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 CRG92905.1 - 0.04 14.0 1.7 0.055 13.5 1.7 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 CRG92905.1 - 0.045 13.9 0.3 0.047 13.8 0.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CHASE3 PF05227.13 CRG92905.1 - 0.05 13.5 0.3 0.12 12.3 0.3 1.6 1 1 1 2 2 2 0 CHASE3 domain IFT46_B_C PF12317.8 CRG92905.1 - 0.077 12.7 1.1 0.094 12.4 1.1 1.1 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal DUF2841 PF11001.8 CRG92906.1 - 4.2e-45 152.8 0.0 7.1e-45 152.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) SH3_2 PF07653.17 CRG92907.1 - 0.13 11.9 0.1 0.41 10.4 0.0 1.8 2 0 0 2 2 2 0 Variant SH3 domain Methyltransf_23 PF13489.6 CRG92908.1 - 1.3e-06 28.4 0.0 1.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 CRG92908.1 - 0.00055 19.8 0.6 0.0044 16.8 0.6 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 CRG92908.1 - 0.0013 19.4 0.1 0.0028 18.3 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 CRG92908.1 - 0.031 13.7 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Methyltransf_12 PF08242.12 CRG92908.1 - 0.038 14.7 0.2 0.13 13.0 0.2 1.9 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 CRG92908.1 - 0.14 11.5 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 CRG92908.1 - 0.19 11.3 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain DDE_3 PF13358.6 CRG92909.1 - 4.6e-32 110.8 0.0 1.6e-31 109.0 0.0 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_33 PF13592.6 CRG92909.1 - 1.6e-06 27.7 0.0 3.6e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix DDE_1 PF03184.19 CRG92909.1 - 1.6e-05 24.6 0.0 3.3e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease rve PF00665.26 CRG92909.1 - 0.00031 20.9 0.0 0.0011 19.2 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_ISAZ013 PF07592.11 CRG92909.1 - 0.0065 15.5 0.1 0.45 9.5 0.0 2.1 2 0 0 2 2 2 2 Rhodopirellula transposase DDE domain HTH_Mga PF08280.11 CRG92909.1 - 0.062 13.3 0.6 5.2 7.2 0.1 2.4 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_29 PF13551.6 CRG92909.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix Allexi_40kDa PF05549.11 CRG92910.1 - 0.0038 16.8 1.1 0.012 15.1 0.6 1.7 1 1 1 2 2 2 1 Allexivirus 40kDa protein GAS PF13851.6 CRG92910.1 - 0.0056 16.1 0.9 0.0071 15.7 0.9 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF1411 PF07199.11 CRG92910.1 - 0.0088 15.7 1.4 0.011 15.5 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1411) FmiP_Thoc5 PF09766.9 CRG92910.1 - 0.012 14.9 1.1 0.013 14.9 1.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 EzrA PF06160.12 CRG92910.1 - 0.02 13.1 3.0 0.024 12.9 3.0 1.3 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 CRG92910.1 - 0.026 14.9 1.6 0.044 14.2 0.3 1.9 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Atg14 PF10186.9 CRG92910.1 - 0.041 13.0 3.2 0.04 13.0 3.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IFT46_B_C PF12317.8 CRG92910.1 - 0.067 12.9 1.9 0.077 12.7 1.9 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal TPR_MLP1_2 PF07926.12 CRG92910.1 - 0.1 12.6 2.5 0.14 12.3 2.5 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Mem_trans PF03547.18 CRG92910.1 - 0.24 9.7 0.3 0.24 9.8 0.3 1.0 1 0 0 1 1 1 0 Membrane transport protein Delta_lysin PF05372.11 CRG92911.1 - 0.16 11.3 1.2 0.25 10.6 1.2 1.3 1 0 0 1 1 1 0 Delta lysin family Prot_inhib_II PF02428.15 CRG92912.1 - 3.1 8.3 5.4 0.56 10.7 0.6 2.0 1 1 1 2 2 2 0 Potato type II proteinase inhibitor family DUF3435 PF11917.8 CRG92915.1 - 6.7e-05 22.0 0.4 6.7e-05 22.0 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3435) Ank_2 PF12796.7 CRG92916.1 - 5.2e-34 116.7 1.7 9.1e-10 39.0 0.0 5.4 5 1 1 6 6 6 5 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG92916.1 - 1.6e-33 114.7 0.6 7.3e-05 23.2 0.0 7.7 5 1 2 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG92916.1 - 1.5e-24 83.3 2.2 0.045 14.3 0.0 10.1 10 0 0 10 10 10 4 Ankyrin repeat Ank PF00023.30 CRG92916.1 - 1.5e-23 82.2 2.7 0.091 13.2 0.0 10.4 11 1 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 CRG92916.1 - 1.3e-21 76.3 6.2 0.00023 21.4 0.0 7.4 6 2 2 8 8 8 5 Ankyrin repeats (many copies) DUF4988 PF16378.5 CRG92916.1 - 0.12 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function zf-C2H2 PF00096.26 CRG92917.1 - 0.0001 22.5 4.2 0.14 12.6 0.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 CRG92917.1 - 0.017 15.9 4.1 0.74 10.8 0.6 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 CRG92917.1 - 0.26 11.1 1.9 0.32 10.8 0.1 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type Ank_2 PF12796.7 CRG92918.1 - 1.2e-23 83.4 1.3 6e-14 52.4 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 CRG92918.1 - 3.8e-23 81.5 2.9 2.3e-10 40.8 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 CRG92918.1 - 9e-21 71.8 1.4 7.4e-06 25.9 0.0 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 CRG92918.1 - 7.4e-19 67.3 3.0 1.2e-07 31.8 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 CRG92918.1 - 6.6e-12 45.4 2.3 0.012 16.0 0.1 4.2 2 2 1 4 4 4 4 Ankyrin repeats (many copies) DUF936 PF06075.12 CRG92920.1 - 0.21 10.4 4.0 0.25 10.2 4.0 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Herpes_DNAp_acc PF04929.12 CRG92920.1 - 1.3 8.0 3.9 1.6 7.6 3.9 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Cep57_MT_bd PF06657.13 CRG92921.1 - 0.033 14.6 1.6 0.088 13.3 0.8 2.0 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 RVT_2 PF07727.14 CRG92922.1 - 5e-40 137.7 0.5 8.7e-40 136.9 0.5 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 CRG92922.1 - 1.8e-06 28.1 0.0 6.3e-06 26.4 0.0 2.0 1 0 0 1 1 1 1 Integrase core domain gag_pre-integrs PF13976.6 CRG92922.1 - 2.6e-06 27.2 0.1 7.6e-06 25.7 0.1 1.9 1 0 0 1 1 1 1 GAG-pre-integrase domain CHZ PF09649.10 CRG92922.1 - 0.49 9.9 7.1 0.21 11.1 0.4 2.8 2 0 0 2 2 2 0 Histone chaperone domain CHZ RT_RNaseH PF17917.1 CRG92924.1 - 2e-35 121.2 0.8 5.8e-35 119.7 0.8 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 CRG92924.1 - 1.5e-32 111.6 0.1 3.6e-32 110.4 0.1 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 CRG92924.1 - 1.4e-23 83.6 0.3 3.4e-23 82.3 0.3 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Integrase_H2C2 PF17921.1 CRG92924.1 - 5.1e-20 71.3 0.1 1.7e-19 69.7 0.1 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain RVP_2 PF08284.11 CRG92924.1 - 4e-14 52.6 0.1 1.1e-13 51.1 0.0 1.7 2 0 0 2 2 2 1 Retroviral aspartyl protease rve PF00665.26 CRG92924.1 - 2.2e-13 50.4 0.4 6.1e-13 49.0 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain Chromo PF00385.24 CRG92924.1 - 5.3e-12 45.5 0.1 1.6e-11 43.9 0.1 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain gag-asp_proteas PF13975.6 CRG92924.1 - 5.4e-12 46.1 0.0 1.4e-11 44.8 0.0 1.8 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 CRG92924.1 - 4.3e-10 40.1 0.0 1e-09 38.9 0.0 1.6 1 0 0 1 1 1 1 Aspartyl protease Asp_protease PF09668.10 CRG92924.1 - 1.5e-07 31.2 0.0 3.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease zf-H2C2 PF09337.10 CRG92924.1 - 0.00024 21.2 0.0 0.0021 18.3 0.0 2.6 2 0 0 2 2 2 1 H2C2 zinc finger SLED PF12140.8 CRG92924.1 - 0.0019 18.7 0.0 0.35 11.4 0.0 3.1 3 0 0 3 3 3 1 SLED domain DUF1643 PF07799.12 CRG92924.1 - 0.02 15.1 0.6 0.16 12.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1643) EST1_DNA_bind PF10373.9 CRG92925.1 - 3.9e-07 29.8 0.7 9.1e-06 25.3 0.1 2.7 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain FA_desaturase PF00487.24 CRG92926.1 - 0.36 10.6 9.2 1.2 8.9 9.1 2.0 1 1 0 1 1 1 0 Fatty acid desaturase RVP PF00077.20 CRG92927.1 - 0.058 13.7 0.0 0.079 13.3 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease Thioesterase PF00975.20 CRG92928.1 - 5.3e-13 49.6 0.2 1.1e-11 45.3 0.2 2.0 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 CRG92928.1 - 7.3e-05 23.5 0.0 7.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 CRG92928.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Phage_holin_3_6 PF07332.11 CRG92929.1 - 0.046 13.8 0.2 0.13 12.3 0.3 1.8 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Abhydrolase_6 PF12697.7 CRG92930.1 - 1.5e-12 48.6 8.6 1.5e-12 48.6 8.6 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 CRG92930.1 - 1.2e-11 44.8 0.0 2.1e-11 44.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 CRG92930.1 - 3.5e-09 36.3 0.0 4.8e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 CRG92930.1 - 0.0015 18.7 0.0 0.0025 18.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain DUF1057 PF06342.12 CRG92930.1 - 0.0073 15.4 0.0 0.0097 15.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_8 PF06259.12 CRG92930.1 - 0.031 13.9 1.2 0.11 12.1 0.0 2.3 3 0 0 3 3 3 0 Alpha/beta hydrolase DUF676 PF05057.14 CRG92930.1 - 0.042 13.4 0.0 0.093 12.2 0.0 1.5 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Ferric_reduct PF01794.19 CRG92932.1 - 0.86 9.7 9.6 0.15 12.2 4.6 2.4 2 1 1 3 3 3 0 Ferric reductase like transmembrane component Comm PF15957.5 CRG92934.1 - 0.0011 19.3 0.0 0.0014 19.0 0.0 1.3 1 0 0 1 1 1 1 Commissureless GAS PF13851.6 CRG92934.1 - 0.0041 16.5 1.1 0.0059 16.0 1.1 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 CRG92934.1 - 0.018 14.0 3.0 0.022 13.7 3.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FmiP_Thoc5 PF09766.9 CRG92934.1 - 0.023 14.0 1.2 0.03 13.6 1.2 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 FlaC_arch PF05377.11 CRG92934.1 - 0.032 14.6 1.1 0.064 13.7 0.4 1.9 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 CRG92934.1 - 0.076 13.1 2.9 0.12 12.4 2.9 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein IFT46_B_C PF12317.8 CRG92934.1 - 0.089 12.5 1.5 0.14 11.9 1.5 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal TetR_C_23 PF17931.1 CRG92934.1 - 0.2 11.8 1.5 4.1 7.6 0.0 2.3 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DivIC PF04977.15 CRG92934.1 - 0.39 10.5 2.2 1.4 8.8 1.4 2.2 1 1 1 2 2 2 0 Septum formation initiator Sporozoite_P67 PF05642.11 CRG92936.1 - 0.18 9.8 1.7 0.27 9.3 1.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3217 PF11506.8 CRG92936.1 - 0.22 11.5 0.0 0.37 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) ABC_tran PF00005.27 CRG92937.1 - 4.1e-27 95.3 0.0 1.1e-26 94.0 0.0 1.7 2 0 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 CRG92937.1 - 2.2e-09 37.4 1.2 4.3e-09 36.4 1.2 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 CRG92937.1 - 0.00056 19.4 0.0 0.0015 18.0 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain G-alpha PF00503.20 CRG92937.1 - 0.0015 17.8 0.0 0.0027 16.9 0.0 1.4 1 0 0 1 1 1 1 G-protein alpha subunit Zeta_toxin PF06414.12 CRG92937.1 - 0.0049 16.2 0.1 0.012 14.9 0.0 1.7 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.6 CRG92937.1 - 0.039 14.3 0.0 0.075 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 CRG92937.1 - 0.083 12.6 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 CRG92937.1 - 0.1 12.3 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 CRG92937.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 CRG92937.1 - 0.14 12.4 0.0 0.8 10.0 0.0 2.2 1 1 0 1 1 1 0 AAA domain Integrase_H2C2 PF17921.1 CRG92938.1 - 5.8e-20 71.1 0.3 1.8e-19 69.6 0.1 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain rve PF00665.26 CRG92938.1 - 7.9e-13 48.7 0.0 1.6e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain Chromo PF00385.24 CRG92938.1 - 1.2e-11 44.3 0.5 2.8e-11 43.1 0.5 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain zf-H2C2 PF09337.10 CRG92938.1 - 1.8e-05 24.8 0.0 4.1e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger DUF4954 PF16314.5 CRG92938.1 - 0.24 9.5 0.3 0.32 9.1 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) PBP1_TM PF14812.6 CRG92939.1 - 0.0029 17.9 1.1 0.0058 17.0 1.1 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3246 PF11596.8 CRG92939.1 - 0.053 13.0 1.0 0.078 12.4 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Nucleo_P87 PF07267.11 CRG92939.1 - 0.24 10.2 1.3 0.31 9.8 1.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4632 PF15451.6 CRG92939.1 - 0.29 11.2 4.0 0.19 11.8 1.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4632) NOA36 PF06524.12 CRG92939.1 - 0.33 10.2 2.6 0.4 10.0 0.2 1.9 2 0 0 2 2 2 0 NOA36 protein Pox_Ag35 PF03286.14 CRG92939.1 - 0.88 9.3 6.6 1.6 8.5 6.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein ORC6 PF05460.13 CRG92939.1 - 8.8 5.5 8.0 12 5.0 8.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) zf-C2H2_4 PF13894.6 CRG92942.1 - 0.12 13.3 8.5 0.18 12.7 0.5 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 CRG92942.1 - 0.35 11.2 6.2 0.25 11.7 3.1 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 CRG92942.1 - 0.6 10.2 6.3 1.8 8.7 2.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Cm_res_leader PF08077.11 CRG92943.1 - 0.054 13.6 1.9 21 5.7 0.0 3.4 2 1 1 3 3 3 0 Chloramphenicol resistance gene leader peptide DDE_1 PF03184.19 CRG92946.1 - 9.7e-47 158.9 0.3 2.3e-46 157.6 0.1 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_ABP1_N PF18107.1 CRG92946.1 - 8.8e-18 63.8 2.2 3.1e-17 62.0 1.5 2.4 2 0 0 2 2 2 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 CRG92946.1 - 1.1e-16 60.6 1.1 1.1e-16 60.6 1.1 2.4 3 0 0 3 3 3 1 Tc5 transposase DNA-binding domain DDE_3 PF13358.6 CRG92946.1 - 0.0005 19.8 0.0 0.0011 18.7 0.0 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease Glyco_hydro_18 PF00704.28 CRG92948.1 - 9.7e-26 91.2 0.1 1.5e-25 90.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 SRF-TF PF00319.18 CRG92949.1 - 3.5e-07 29.6 0.4 6.3e-07 28.8 0.0 1.6 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SBP_bac_5 PF00496.22 CRG92950.1 - 1.8e-74 251.0 0.3 2.5e-74 250.5 0.3 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Glyco_hydro_64 PF16483.5 CRG92952.1 - 9.9e-89 298.2 0.0 1.1e-88 298.0 0.0 1.0 1 0 0 1 1 1 1 Beta-1,3-glucanase VQ PF05678.14 CRG92952.1 - 3.1 7.4 4.7 0.89 9.1 1.4 1.8 2 0 0 2 2 2 0 VQ motif AAA_33 PF13671.6 CRG92953.1 - 3e-19 69.6 0.0 4.9e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 CRG92953.1 - 4.7e-09 36.9 0.0 8.4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 CRG92953.1 - 0.00075 19.9 0.0 1.6 9.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 CRG92953.1 - 0.00095 18.5 0.0 0.0036 16.6 0.0 1.9 1 1 0 1 1 1 1 Zeta toxin AAA_28 PF13521.6 CRG92953.1 - 0.019 15.2 0.1 0.059 13.6 0.1 2.0 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 CRG92953.1 - 0.02 14.7 0.4 0.24 11.2 0.4 2.1 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TOBE PF03459.17 CRG92953.1 - 0.025 14.8 0.1 0.064 13.6 0.1 1.6 1 0 0 1 1 1 0 TOBE domain dNK PF01712.19 CRG92953.1 - 0.074 12.9 0.0 1.6 8.5 0.0 2.1 2 0 0 2 2 2 0 Deoxynucleoside kinase SKI PF01202.22 CRG92953.1 - 0.098 12.8 0.3 0.83 9.8 0.3 2.1 1 1 0 1 1 1 0 Shikimate kinase Cytidylate_kin PF02224.18 CRG92953.1 - 0.19 11.5 0.0 11 5.6 0.0 2.1 2 0 0 2 2 2 0 Cytidylate kinase F-box-like PF12937.7 CRG92954.1 - 0.096 12.6 1.2 0.25 11.3 1.2 1.7 1 0 0 1 1 1 0 F-box-like # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_islandicus-PIS/GCA_000985935.1_PIS_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_islandicus-PIS/GCA_000985935.1_PIS_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_islandicus-PIS/GCA_000985935.1_PIS_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Talaromyces_islandicus-PIS/GCA_000985935.1_PIS_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 06:32:17 2019 # [ok]