# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DUF2306 PF10067.9 ETS59435.1 - 7.3e-07 29.5 9.8 7.3e-06 26.3 9.8 2.5 1 1 0 1 1 1 1 Predicted membrane protein (DUF2306) PepSY_TM PF03929.16 ETS59435.1 - 1.3 8.6 6.5 1.3 8.6 4.0 2.4 2 1 0 2 2 2 0 PepSY-associated TM region ATG22 PF11700.8 ETS59436.1 - 7.9e-44 150.1 16.0 1e-43 149.7 16.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Fungal_trans PF04082.18 ETS59438.1 - 1.2e-18 67.2 0.0 2.3e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS59438.1 - 1.4e-09 37.9 11.6 2.4e-09 37.1 11.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PhyH PF05721.13 ETS59439.1 - 4e-10 40.3 0.1 1.1e-09 38.9 0.1 1.8 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ETS59439.1 - 9.1e-06 24.7 0.1 0.17 10.6 0.1 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF1479) 2OG-FeII_Oxy_5 PF13759.6 ETS59439.1 - 0.0044 17.4 0.0 0.011 16.2 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase FAD_binding_3 PF01494.19 ETS59440.1 - 2.2e-19 69.9 0.5 5.3e-19 68.7 0.5 1.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETS59440.1 - 2.7e-10 40.4 2.7 4.3e-05 23.3 0.7 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS59440.1 - 3.2e-06 26.6 0.8 0.0095 15.2 0.3 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS59440.1 - 3.5e-05 23.9 0.6 0.00014 22.1 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ETS59440.1 - 0.00017 21.0 1.8 0.045 13.0 0.0 2.2 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 ETS59440.1 - 0.00019 20.4 0.3 0.015 14.2 0.0 2.6 3 0 0 3 3 3 1 Tryptophan halogenase FAD_binding_2 PF00890.24 ETS59440.1 - 0.00059 19.0 1.9 0.0012 18.0 1.9 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ETS59440.1 - 0.0013 17.5 1.0 0.018 13.8 0.3 2.1 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 ETS59440.1 - 0.011 14.9 6.0 0.89 8.5 0.0 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox PF00070.27 ETS59440.1 - 0.013 16.1 0.4 0.76 10.4 0.2 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 ETS59440.1 - 0.02 14.0 0.0 0.054 12.6 0.0 1.6 2 0 0 2 2 2 0 Squalene epoxidase FAD_oxidored PF12831.7 ETS59440.1 - 0.036 13.4 0.7 0.036 13.4 0.7 1.6 3 0 0 3 3 3 0 FAD dependent oxidoreductase Thi4 PF01946.17 ETS59440.1 - 0.085 12.1 0.1 0.19 10.9 0.1 1.5 2 0 0 2 2 2 0 Thi4 family GIDA PF01134.22 ETS59440.1 - 0.12 11.5 0.1 0.18 10.9 0.1 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A ApbA PF02558.16 ETS59440.1 - 0.12 12.0 0.2 0.22 11.2 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA MFS_1 PF07690.16 ETS59442.1 - 4.8e-25 88.2 39.5 6.8e-24 84.4 34.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS59442.1 - 2e-11 43.5 16.6 2e-11 43.5 16.6 3.3 2 2 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 ETS59442.1 - 4.6e-08 31.9 5.3 8.3e-08 31.1 5.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ETS59443.1 - 1.6e-88 297.5 15.7 2e-88 297.2 15.7 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS59443.1 - 8.3e-20 71.0 36.5 3.1e-16 59.3 17.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETS59443.1 - 4e-07 29.0 12.2 0.0006 18.5 1.5 2.7 2 1 0 2 2 2 2 MFS/sugar transport protein Gln-synt_C PF00120.24 ETS59445.1 - 4.9e-69 233.0 0.0 1.3e-68 231.6 0.0 1.6 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Aldedh PF00171.22 ETS59446.1 - 1.6e-126 422.6 0.0 1.8e-126 422.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETS59446.1 - 0.05 12.7 0.1 0.29 10.1 0.0 2.1 2 1 0 2 2 2 0 Acyl-CoA reductase (LuxC) adh_short_C2 PF13561.6 ETS59447.1 - 8.2e-64 215.3 0.1 1e-63 215.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS59447.1 - 6e-45 153.1 0.3 7.3e-45 152.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS59447.1 - 2.6e-07 30.7 0.3 5.4e-07 29.7 0.3 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ETS59447.1 - 0.0014 18.5 0.2 0.0062 16.4 0.1 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain OPT PF03169.15 ETS59448.1 - 3.1e-130 435.7 49.0 3.6e-130 435.5 49.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein FAD_binding_3 PF01494.19 ETS59449.1 - 3.4e-21 75.9 0.0 4.8e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ETS59449.1 - 4.1e-06 26.9 1.0 1e-05 25.7 1.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETS59449.1 - 5.1e-06 25.9 1.1 5.2e-05 22.6 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS59449.1 - 0.00011 21.4 0.0 0.00015 21.0 0.0 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 ETS59449.1 - 0.00044 19.9 0.0 0.00062 19.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETS59449.1 - 0.0005 19.3 2.1 0.0014 17.8 1.6 2.0 2 1 1 3 3 3 1 FAD binding domain FAD_oxidored PF12831.7 ETS59449.1 - 0.0011 18.4 0.0 0.0016 17.9 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETS59449.1 - 0.019 15.5 0.5 0.057 14.0 0.5 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETS59449.1 - 0.035 13.0 0.3 0.35 9.6 0.2 2.3 3 0 0 3 3 3 0 Tryptophan halogenase ApbA PF02558.16 ETS59449.1 - 0.052 13.2 0.9 6.3 6.4 0.0 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 ETS59449.1 - 0.11 11.6 3.5 0.09 11.8 1.7 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 ETS59449.1 - 0.13 11.6 0.1 0.25 10.6 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 ETS59449.1 - 0.16 11.2 0.0 0.49 9.6 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 ETS59449.1 - 0.17 10.6 0.6 0.31 9.7 0.6 1.4 1 0 0 1 1 1 0 HI0933-like protein Fungal_trans PF04082.18 ETS59450.1 - 2e-08 33.6 0.8 3.5e-08 32.8 0.8 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS59450.1 - 4.7e-07 29.8 9.6 8.5e-07 29.0 9.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EthD PF07110.11 ETS59451.1 - 1.1e-17 65.0 0.2 2e-17 64.1 0.2 1.5 1 0 0 1 1 1 1 EthD domain COesterase PF00135.28 ETS59452.1 - 2e-86 290.9 0.5 2.5e-86 290.6 0.5 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS59452.1 - 2.6e-06 27.5 0.7 2e-05 24.6 0.7 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETS59452.1 - 0.0043 16.6 0.2 0.0096 15.4 0.2 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 ETS59452.1 - 0.011 14.7 0.0 0.035 13.0 0.0 1.7 1 1 0 1 1 1 0 Steryl acetyl hydrolase ELO PF01151.18 ETS59453.1 - 9.6e-57 192.4 17.3 1.2e-56 192.1 17.3 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family CoA_transf_3 PF02515.17 ETS59454.1 - 5.6e-65 219.9 0.0 1.8e-64 218.2 0.0 1.6 1 1 0 1 1 1 1 CoA-transferase family III GFO_IDH_MocA PF01408.22 ETS59455.1 - 1e-16 61.8 0.0 2.6e-16 60.5 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ETS59455.1 - 0.00028 20.9 0.0 0.0014 18.6 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Zn_clus PF00172.18 ETS59455.1 - 0.00057 20.0 8.3 0.00057 20.0 8.3 2.4 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain XLF PF09302.11 ETS59455.1 - 0.047 13.9 0.3 0.9 9.7 0.0 2.7 3 0 0 3 3 3 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Sugar_tr PF00083.24 ETS59456.1 - 8.3e-81 272.1 21.8 1.1e-80 271.8 21.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS59456.1 - 3.9e-20 72.1 36.3 4.4e-14 52.2 17.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETS59456.1 - 6.7e-09 34.8 15.4 9.3e-05 21.2 5.2 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein DUF2951 PF11166.8 ETS59456.1 - 0.0095 16.1 2.2 2.7 8.3 0.2 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF2951) DUF2206 PF09971.9 ETS59456.1 - 0.011 14.5 0.5 0.041 12.6 0.3 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) DUF3007 PF11460.8 ETS59456.1 - 3.4 8.0 5.5 7.9 6.8 2.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3007) Acetyltransf_1 PF00583.25 ETS59457.1 - 2.6e-09 37.3 0.0 3.4e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETS59457.1 - 3.4e-08 33.5 0.0 4.5e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS59457.1 - 9.5e-07 29.2 0.0 1.3e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETS59457.1 - 0.053 13.7 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase RAI1 PF08652.11 ETS59458.1 - 4.4e-20 71.6 0.0 8e-20 70.8 0.0 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease DUF3486 PF11985.8 ETS59458.1 - 0.16 12.4 3.1 8.6 6.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) UQ_con PF00179.26 ETS59459.1 - 5.3e-17 61.8 0.0 1.1e-16 60.7 0.0 1.6 1 1 1 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETS59459.1 - 0.12 12.6 0.0 0.5 10.7 0.0 1.9 2 0 0 2 2 2 0 RWD domain FAP PF07174.11 ETS59459.1 - 4.1 6.8 24.7 6 6.2 24.7 1.3 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) TPT PF03151.16 ETS59460.1 - 1.9e-52 178.5 12.1 2.9e-52 177.8 12.1 1.3 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ETS59460.1 - 5e-15 55.9 20.6 4.1e-10 40.0 9.1 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ETS59460.1 - 3.5e-10 39.6 11.2 4.4e-10 39.2 11.2 1.1 1 0 0 1 1 1 1 UAA transporter family Nuc_sug_transp PF04142.15 ETS59460.1 - 0.00019 20.8 9.2 0.0046 16.2 0.4 2.6 2 1 0 2 2 2 2 Nucleotide-sugar transporter TMEM100 PF16311.5 ETS59460.1 - 0.091 12.4 3.1 2.8 7.5 0.2 3.0 2 1 0 3 3 3 0 Transmembrane protein 100 Multi_Drug_Res PF00893.19 ETS59460.1 - 0.98 10.1 8.3 0.12 13.1 2.7 2.3 2 1 0 2 2 2 0 Small Multidrug Resistance protein MBOAT_2 PF13813.6 ETS59462.1 - 1.7e-05 25.0 1.2 0.0015 18.8 0.3 2.7 2 0 0 2 2 2 2 Membrane bound O-acyl transferase family DUF1129 PF06570.11 ETS59462.1 - 0.63 9.5 5.5 1.5 8.2 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) ABC_tran PF00005.27 ETS59463.1 - 6.2e-22 78.6 0.0 6.2e-16 59.1 0.0 2.4 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ETS59463.1 - 5.6e-08 33.0 1.0 0.022 14.5 0.0 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ETS59463.1 - 0.00014 22.0 0.0 0.059 13.6 0.0 2.8 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_16 PF13191.6 ETS59463.1 - 0.0056 17.1 1.9 0.014 15.8 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ETS59463.1 - 0.0057 16.4 0.3 0.016 15.0 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain NACHT PF05729.12 ETS59463.1 - 0.017 15.1 0.1 0.088 12.7 0.0 2.2 3 0 0 3 3 3 0 NACHT domain AAA_24 PF13479.6 ETS59463.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETS59463.1 - 0.098 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 ETS59463.1 - 0.24 10.5 0.0 0.39 9.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 F_bP_aldolase PF01116.20 ETS59464.1 - 1e-73 248.3 0.0 1.2e-73 248.1 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II WD40 PF00400.32 ETS59465.1 - 1.6e-31 107.9 13.9 2.1e-05 25.2 0.0 10.8 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS59465.1 - 1e-13 51.3 0.8 0.00014 22.1 0.2 5.7 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS59465.1 - 5.7e-07 28.8 5.3 0.17 10.9 0.1 4.4 3 1 0 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETS59465.1 - 3.1e-05 23.4 0.4 0.44 9.8 0.0 3.9 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal RAB3GAP2_N PF14655.6 ETS59465.1 - 0.00031 20.1 0.0 0.8 8.9 0.0 3.5 2 1 1 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus BBS2_N PF14781.6 ETS59465.1 - 0.0038 17.1 0.1 0.037 13.9 0.0 2.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, N-terminal Frtz PF11768.8 ETS59465.1 - 0.011 14.1 0.0 0.022 13.1 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETS59465.1 - 0.018 13.8 0.0 0.22 10.2 0.0 2.5 2 0 0 2 2 2 0 Nup133 N terminal like DUF2850 PF11012.8 ETS59465.1 - 0.093 13.0 0.0 0.45 10.9 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2850) Nup160 PF11715.8 ETS59465.1 - 0.12 11.0 0.0 0.79 8.3 0.0 2.2 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Asp_Glu_race PF01177.22 ETS59467.1 - 1.3e-07 31.8 0.1 5e-07 29.8 0.1 1.8 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Amdase PF17645.1 ETS59467.1 - 0.031 13.9 1.3 0.057 13.0 0.2 2.0 3 0 0 3 3 3 0 Arylmalonate decarboxylase AroM PF07302.11 ETS59467.1 - 0.098 12.0 0.2 0.39 10.1 0.1 1.9 1 1 1 2 2 2 0 AroM protein FAD_binding_4 PF01565.23 ETS59468.1 - 3.4e-25 88.4 1.6 7.1e-25 87.4 1.6 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ETS59468.1 - 9.1e-13 48.1 0.1 1.6e-12 47.3 0.1 1.5 1 0 0 1 1 1 1 Berberine and berberine like TRSP PF12500.8 ETS59468.1 - 0.11 12.3 0.1 0.25 11.2 0.1 1.6 1 0 0 1 1 1 0 TRSP domain C terminus to PRTase_2 COA2 PF17051.5 ETS59469.1 - 0.0014 18.6 0.0 0.0015 18.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 LCCL PF03815.19 ETS59470.1 - 9.8e-17 60.9 0.0 1.9e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 LCCL domain DUF1308 PF07000.11 ETS59470.1 - 0.00028 20.8 0.3 0.7 9.8 0.1 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF1308) ADH_N PF08240.12 ETS59471.1 - 2.9e-21 75.4 3.6 5.8e-21 74.4 3.6 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS59471.1 - 3e-16 59.6 0.0 4.6e-15 55.8 0.0 2.4 2 1 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ETS59471.1 - 0.00026 20.4 0.0 0.0004 19.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ETS59471.1 - 0.0014 18.8 0.0 0.0032 17.7 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 ETS59471.1 - 0.0039 16.8 0.0 0.0093 15.6 0.0 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA AlaDh_PNT_C PF01262.21 ETS59471.1 - 0.019 14.3 1.2 0.024 14.0 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 ETS59471.1 - 0.047 13.7 0.0 0.13 12.3 0.0 1.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ETS59471.1 - 0.054 13.9 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ETS59471.1 - 0.11 12.3 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.16 ETS59472.1 - 4.5e-14 52.1 50.3 7.2e-07 28.4 23.5 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Acetyltransf_10 PF13673.7 ETS59473.1 - 5.4e-07 29.6 0.0 8.6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS59473.1 - 9.1e-07 29.1 0.0 1.3e-06 28.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS59473.1 - 1.4e-05 25.4 0.0 2.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS59473.1 - 0.028 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 ETS59473.1 - 0.047 13.8 0.1 6.6 6.8 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain GET2 PF08690.10 ETS59473.1 - 0.064 12.9 0.2 0.15 11.7 0.0 1.6 2 0 0 2 2 2 0 GET complex subunit GET2 zf-C3HC4_3 PF13920.6 ETS59474.1 - 1.3e-06 28.1 8.0 2e-06 27.5 8.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS59474.1 - 8.6e-06 26.0 13.7 1.6e-05 25.1 13.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETS59474.1 - 0.00085 19.1 11.6 0.0014 18.5 11.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS59474.1 - 0.0033 17.2 12.6 0.0062 16.4 12.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETS59474.1 - 0.013 15.8 8.9 0.027 14.8 8.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETS59474.1 - 1.2 9.1 9.7 2.1 8.3 9.7 1.4 1 0 0 1 1 1 0 zinc-RING finger domain dCMP_cyt_deam_1 PF00383.23 ETS59475.1 - 2.3e-08 33.8 0.0 6.3e-08 32.4 0.0 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETS59475.1 - 0.00013 21.8 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 MafB19-like deaminase DUF3135 PF11333.8 ETS59475.1 - 0.04 14.2 0.2 0.13 12.5 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) Bap31_Bap29_C PF18035.1 ETS59475.1 - 0.14 12.2 1.5 0.26 11.3 1.5 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Pirin PF02678.16 ETS59476.1 - 1.3e-27 95.9 0.2 2.6e-27 95.0 0.2 1.5 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 ETS59476.1 - 8.3e-24 83.9 0.1 1.1e-22 80.3 0.1 2.5 2 1 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 ETS59476.1 - 0.0019 17.8 2.9 0.0085 15.8 1.6 2.6 3 0 0 3 3 3 1 Cupin domain zf-C2H2 PF00096.26 ETS59477.1 - 1.3e-06 28.5 8.4 0.0015 18.9 0.8 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS59477.1 - 9.4e-05 22.9 8.2 0.015 16.1 0.7 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETS59477.1 - 0.0033 17.8 0.3 0.0033 17.8 0.3 3.3 4 0 0 4 4 4 1 Zinc-finger double domain Zn_ribbon_SprT PF17283.2 ETS59477.1 - 0.0095 15.8 0.1 0.03 14.2 0.1 1.9 1 0 0 1 1 1 1 SprT-like zinc ribbon domain DUF3493 PF11998.8 ETS59477.1 - 0.011 15.8 0.0 0.028 14.6 0.0 1.6 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 IBR PF01485.21 ETS59477.1 - 0.021 15.1 0.3 0.072 13.3 0.3 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Quaking_NLS PF16551.5 ETS59477.1 - 3.4 7.4 8.0 4.2 7.1 1.1 2.5 2 0 0 2 2 2 0 Putative nuclear localisation signal of quaking adh_short PF00106.25 ETS59478.1 - 2.7e-37 128.1 0.0 4.5e-37 127.4 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS59478.1 - 5.5e-27 94.8 0.0 1.1e-26 93.8 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ETS59478.1 - 1e-06 28.4 0.0 1.5e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ETS59478.1 - 1.7e-06 28.1 0.9 1.4e-05 25.1 0.9 2.2 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 ETS59478.1 - 0.0015 17.6 0.1 0.0022 17.0 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETS59478.1 - 0.0033 17.3 0.0 0.007 16.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)H-binding 2-Hacid_dh_C PF02826.19 ETS59478.1 - 0.0048 16.3 0.0 0.008 15.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GDP_Man_Dehyd PF16363.5 ETS59478.1 - 0.03 13.7 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ETS59478.1 - 0.062 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 ETS59478.1 - 0.093 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Methyltransf_11 PF08241.12 ETS59479.1 - 8.8e-18 64.7 0.0 2.1e-17 63.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS59479.1 - 8.6e-16 58.4 0.0 4.2e-15 56.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS59479.1 - 1.3e-08 35.4 0.0 5.3e-08 33.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS59479.1 - 3.3e-06 27.0 0.0 1.4e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS59479.1 - 2.4e-05 23.8 0.0 6.1e-05 22.5 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ETS59479.1 - 3.2e-05 23.8 0.0 5e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF4210 PF13915.6 ETS59480.1 - 4.4e-29 100.9 0.0 1.1e-28 99.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 ETS59480.1 - 2.1e-19 69.4 0.0 4.7e-19 68.3 0.0 1.7 1 0 0 1 1 1 1 Chromosome segregation during meiosis Sulfate_transp PF00916.20 ETS59482.1 - 3.3e-109 365.1 17.4 4.2e-109 364.8 17.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ETS59482.1 - 1.3e-10 41.0 0.0 2.4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ETS59482.1 - 0.0011 19.3 11.1 0.0014 19.0 1.4 2.9 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily DUF2810 PF10928.8 ETS59484.1 - 0.18 11.8 0.1 0.33 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2810) Biliv-reduc_cat PF09166.10 ETS59485.1 - 0.057 13.7 0.0 0.098 13.0 0.0 1.4 1 0 0 1 1 1 0 Biliverdin reductase, catalytic Ion_trans_2 PF07885.16 ETS59487.1 - 2.9e-31 107.2 29.5 2.5e-16 59.4 9.0 3.0 3 0 0 3 3 3 2 Ion channel Ion_trans PF00520.31 ETS59487.1 - 3.6e-07 29.7 8.7 0.00014 21.1 0.4 2.6 2 0 0 2 2 2 2 Ion transport protein Ctr PF04145.15 ETS59487.1 - 0.015 15.9 2.9 0.96 10.1 0.0 3.6 2 1 0 2 2 2 0 Ctr copper transporter family ADK PF00406.22 ETS59488.1 - 1.3e-46 158.4 0.0 1.7e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETS59488.1 - 1.3e-23 83.9 0.0 3.4e-23 82.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 ETS59488.1 - 8.3e-15 54.5 0.0 1.5e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ETS59488.1 - 4.4e-05 24.0 0.0 7.9e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETS59488.1 - 0.00044 20.4 0.1 0.0053 16.9 0.1 2.3 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ETS59488.1 - 0.047 13.4 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Thymidylate kinase Hydin_ADK PF17213.3 ETS59488.1 - 0.051 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain adh_short_C2 PF13561.6 ETS59489.1 - 1.1e-52 178.9 0.2 1.9e-52 178.1 0.2 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS59489.1 - 1.1e-48 165.3 0.4 1.8e-48 164.6 0.4 1.3 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS59489.1 - 4.6e-12 46.2 0.3 6e-12 45.8 0.3 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS59489.1 - 0.0013 18.3 0.1 0.0024 17.4 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ETS59489.1 - 0.038 13.1 0.5 0.29 10.2 0.2 2.0 2 0 0 2 2 2 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ETS59489.1 - 0.13 11.6 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase SR-25 PF10500.9 ETS59490.1 - 0.068 12.8 13.7 0.082 12.5 13.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 ETS59490.1 - 0.53 7.4 5.5 0.53 7.3 5.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer IMUP PF15761.5 ETS59490.1 - 1.8 9.3 10.8 3.2 8.5 10.8 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein Aldo_ket_red PF00248.21 ETS59492.1 - 7e-43 146.9 0.0 2.3e-30 105.8 0.0 2.0 1 1 1 2 2 2 2 Aldo/keto reductase family Fe-ADH PF00465.19 ETS59493.1 - 5.9e-91 305.0 0.0 9.1e-91 304.4 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ETS59493.1 - 7.8e-11 42.2 0.0 1.9e-08 34.4 0.0 2.4 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Hydrolase_4 PF12146.8 ETS59493.1 - 0.11 11.8 0.0 0.26 10.5 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 MAPEG PF01124.18 ETS59494.1 - 6.3e-12 45.5 7.0 7.8e-12 45.2 7.0 1.1 1 0 0 1 1 1 1 MAPEG family HupE_UreJ_2 PF13795.6 ETS59494.1 - 0.05 13.3 0.3 0.47 10.1 0.4 1.9 2 0 0 2 2 2 0 HupE / UreJ protein AMP-binding PF00501.28 ETS59495.1 - 2.6e-74 250.3 0.1 3.4e-74 250.0 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS59495.1 - 1.6e-16 61.0 0.2 4.9e-16 59.5 0.2 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Lipase_GDSL_2 PF13472.6 ETS59496.1 - 1.7e-18 67.7 0.2 2.3e-18 67.2 0.2 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ETS59496.1 - 2.8e-05 24.2 0.0 3.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_3 PF14606.6 ETS59496.1 - 0.011 15.8 0.1 5.9 7.0 0.1 2.5 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase family MS_channel PF00924.18 ETS59497.1 - 2.3e-22 79.6 1.3 4.1e-22 78.7 1.3 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 ETS59497.1 - 0.004 16.6 0.2 0.0072 15.8 0.2 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETS59497.1 - 0.0073 16.2 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETS59497.1 - 0.18 12.3 0.1 0.39 11.2 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_5 PF13202.6 ETS59497.1 - 0.19 11.3 0.2 0.34 10.5 0.2 1.4 1 0 0 1 1 1 0 EF hand IQ PF00612.27 ETS59503.1 - 4.3e-05 22.9 0.3 0.00011 21.7 0.3 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif SR-25 PF10500.9 ETS59503.1 - 0.006 16.2 13.3 0.006 16.2 13.3 2.7 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF3027 PF11228.8 ETS59503.1 - 2.8 7.9 5.5 1.2 9.1 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) OAD_gamma PF04277.13 ETS59503.1 - 8.9 7.0 5.1 3.8 8.2 0.7 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Urm1 PF09138.11 ETS59504.1 - 2.9e-35 120.5 0.0 3.3e-35 120.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 ETS59504.1 - 4e-06 27.4 0.0 5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 ThiS family Glyco_hydro_47 PF01532.20 ETS59505.1 - 6.3e-156 519.8 0.0 7.5e-156 519.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CX9C PF16860.5 ETS59507.1 - 3.5e-17 62.1 6.7 1.5e-13 50.5 1.2 2.3 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, UCR_hinge PF02320.16 ETS59507.1 - 0.00016 21.8 8.4 0.00035 20.7 0.7 2.9 1 1 1 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein CHCH PF06747.13 ETS59507.1 - 0.018 15.2 3.9 0.21 11.8 1.0 3.0 2 1 1 3 3 3 0 CHCH domain Cmc1 PF08583.10 ETS59507.1 - 0.071 13.1 8.3 0.43 10.6 1.3 2.9 1 1 1 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX6B PF02297.17 ETS59507.1 - 0.073 13.3 5.4 1 9.7 0.3 2.4 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb NDUF_B7 PF05676.13 ETS59507.1 - 0.28 10.9 3.0 1.1 9.0 0.4 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) MTCP1 PF08991.10 ETS59507.1 - 1.1 9.5 9.3 6.9 7.0 1.9 3.0 2 1 1 3 3 3 0 Mature-T-Cell Proliferation I type DUF3128 PF11326.8 ETS59507.1 - 2 8.9 8.3 5.5 7.4 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3128) GCK PF07802.11 ETS59507.1 - 2 8.9 5.2 25 5.4 0.2 2.7 1 1 3 4 4 4 0 GCK domain zf-C2HC5 PF06221.13 ETS59508.1 - 4.5e-16 58.6 4.9 7.2e-16 57.9 4.9 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type zf-ribbon_3 PF13248.6 ETS59508.1 - 0.051 13.0 0.7 11 5.6 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 ETS59508.1 - 0.74 9.9 4.8 1.4 9.0 4.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon DHHC PF01529.20 ETS59509.1 - 2.7e-31 108.4 0.1 2.7e-31 108.4 0.1 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase TackOD1 PF18551.1 ETS59509.1 - 0.046 13.4 0.4 0.072 12.7 0.4 1.3 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 DUF2613 PF11021.8 ETS59509.1 - 0.13 12.4 0.8 13 6.0 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) His_Phos_2 PF00328.22 ETS59510.1 - 2e-10 40.6 0.1 3.4e-05 23.4 0.2 2.6 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) Aa_trans PF01490.18 ETS59511.1 - 1.1e-78 264.8 12.9 1.3e-78 264.5 12.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein YfhO PF09586.10 ETS59511.1 - 0.68 8.1 6.9 1.2 7.2 6.9 1.4 1 0 0 1 1 1 0 Bacterial membrane protein YfhO IMS PF00817.20 ETS59512.1 - 1.1e-37 129.3 0.0 2.7e-37 128.1 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 ETS59512.1 - 1.2e-14 54.4 0.4 2.5e-14 53.4 0.4 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 ETS59512.1 - 4.5e-11 43.5 0.1 2.1e-10 41.4 0.0 2.2 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 ETS59512.1 - 1.8e-06 28.2 0.0 4.5e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETS59512.1 - 0.00046 20.5 0.0 0.00095 19.5 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain IMS_HHH PF11798.8 ETS59512.1 - 0.0014 18.8 0.0 0.0039 17.4 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif UBM PF14377.6 ETS59512.1 - 0.0016 17.8 10.4 0.61 9.6 0.1 4.3 4 0 0 4 4 4 2 Ubiquitin binding region DUF1805 PF08827.11 ETS59512.1 - 0.06 13.7 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) DUF2569 PF10754.9 ETS59513.1 - 3.1 8.2 8.4 0.7 10.3 3.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2569) PALP PF00291.25 ETS59515.1 - 4.4e-53 180.6 0.0 4.6e-26 91.9 0.0 2.1 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme LapA_dom PF06305.11 ETS59515.1 - 0.16 11.8 0.9 0.28 11.0 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain TFR_dimer PF04253.15 ETS59516.1 - 7.2e-22 77.8 0.0 2.3e-21 76.1 0.0 1.8 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ETS59516.1 - 9e-19 67.9 0.2 1.5e-18 67.2 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ETS59516.1 - 8.2e-15 54.6 1.1 1.8e-14 53.5 1.1 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ETS59516.1 - 0.078 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 Nicastrin PF05450.15 ETS59516.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 Nicastrin Mito_carr PF00153.27 ETS59517.1 - 1.1e-54 182.3 6.5 9.2e-19 67.2 0.3 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ETS59517.1 - 0.0047 16.1 1.2 0.19 10.9 0.0 3.0 3 1 0 3 3 3 1 Gammaproteobacterial serine protease Vac14_Fig4_bd PF11916.8 ETS59517.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Vacuolar protein 14 C-terminal Fig4p binding Bac_luciferase PF00296.20 ETS59518.1 - 2.4e-63 214.5 3.8 3.1e-63 214.1 3.8 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Metallothio_11 PF02066.15 ETS59519.1 - 0.11 12.7 3.5 0.9 9.8 0.1 3.9 4 0 0 4 4 4 0 Metallothionein family 11 Trehalase PF01204.18 ETS59520.1 - 2.5e-114 382.9 1.8 2e-103 346.9 0.0 2.1 2 0 0 2 2 2 2 Trehalase GDE_C PF06202.14 ETS59520.1 - 0.00014 21.0 0.3 0.00046 19.2 0.1 1.8 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase DFF-C PF09033.10 ETS59520.1 - 0.01 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 DNA Fragmentation factor 45kDa, C terminal domain PNK3P PF08645.11 ETS59521.1 - 3.5e-45 153.6 0.0 5e-45 153.1 0.0 1.2 1 0 0 1 1 1 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ETS59521.1 - 1.6e-22 80.2 1.0 7.1e-13 48.9 0.2 2.7 2 1 1 3 3 3 2 AAA domain Zeta_toxin PF06414.12 ETS59521.1 - 0.00073 18.9 0.0 0.26 10.6 0.0 2.3 2 0 0 2 2 2 2 Zeta toxin AAA_16 PF13191.6 ETS59521.1 - 0.011 16.2 0.0 0.019 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain KTI12 PF08433.10 ETS59521.1 - 0.062 12.7 1.8 0.85 9.0 0.5 2.1 1 1 1 2 2 2 0 Chromatin associated protein KTI12 RhoGEF67_u2 PF16614.5 ETS59521.1 - 0.14 12.3 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 Mg_chelatase PF01078.21 ETS59521.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI 6PF2K PF01591.18 ETS59521.1 - 0.17 11.2 0.4 17 4.6 0.2 2.2 1 1 1 2 2 2 0 6-phosphofructo-2-kinase G_glu_transpept PF01019.21 ETS59522.1 - 2.1e-143 478.8 0.1 2.4e-143 478.6 0.1 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase ACOX PF01756.19 ETS59523.1 - 8.2e-44 149.3 0.9 2e-43 148.0 0.1 1.9 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ETS59523.1 - 9.1e-24 84.4 0.2 1.8e-23 83.4 0.2 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ETS59523.1 - 6.1e-13 48.8 0.0 1.1e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ETS59523.1 - 0.00038 20.7 0.4 0.023 14.9 0.4 2.5 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DUF5549 PF17703.1 ETS59524.1 - 0.07 12.8 1.1 0.082 12.5 1.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5549) Zn_clus PF00172.18 ETS59525.1 - 4.8e-06 26.6 11.0 8.1e-06 25.9 11.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_88 PF07470.13 ETS59526.1 - 8.1e-17 61.3 1.2 1.3e-16 60.6 1.2 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 AMP-binding PF00501.28 ETS59526.1 - 1.2e-06 27.4 0.0 2e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PAN_4 PF14295.6 ETS59528.1 - 0.00062 19.6 0.6 0.0015 18.4 0.6 1.7 1 0 0 1 1 1 1 PAN domain MANEC PF07502.14 ETS59528.1 - 0.0094 16.2 0.1 0.04 14.2 0.0 2.0 2 0 0 2 2 2 1 MANEC domain Trp_oprn_chp PF09534.10 ETS59528.1 - 0.12 12.1 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Methyltransf_12 PF08242.12 ETS59529.1 - 8e-06 26.5 0.0 1.8e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS59529.1 - 8.6e-06 26.3 0.1 3.1e-05 24.5 0.1 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS59529.1 - 3e-05 24.7 0.0 0.00029 21.5 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS59529.1 - 0.00022 21.1 0.0 0.00032 20.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_28 PF02636.17 ETS59529.1 - 0.013 15.1 0.0 0.026 14.1 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase HSP90 PF00183.18 ETS59529.1 - 0.043 12.7 0.0 0.056 12.3 0.0 1.1 1 0 0 1 1 1 0 Hsp90 protein Methyltransf_33 PF10017.9 ETS59529.1 - 0.17 11.0 0.1 0.73 8.9 0.0 1.8 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent Sugar_tr PF00083.24 ETS59531.1 - 5.5e-109 365.0 16.1 6.6e-109 364.8 16.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS59531.1 - 1.9e-18 66.5 40.8 2.7e-15 56.2 20.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Pox_A14 PF05767.12 ETS59531.1 - 0.16 12.2 0.0 0.16 12.2 0.0 2.9 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 AgrB PF04647.15 ETS59531.1 - 4.4 6.6 10.2 0.56 9.5 0.1 3.3 2 1 1 3 3 3 0 Accessory gene regulator B FYRN PF05964.14 ETS59533.1 - 0.17 11.8 0.1 0.26 11.1 0.1 1.3 1 0 0 1 1 1 0 F/Y-rich N-terminus Glyco_hydro_42 PF02449.15 ETS59534.1 - 4.1e-116 388.4 4.9 5.3e-116 388.0 4.9 1.1 1 0 0 1 1 1 1 Beta-galactosidase Glyco_hydro_42M PF08532.10 ETS59534.1 - 1.7e-27 96.3 0.0 3.2e-27 95.4 0.0 1.5 1 0 0 1 1 1 1 Beta-galactosidase trimerisation domain Glyco_hydro_42C PF08533.10 ETS59534.1 - 0.0021 17.7 0.0 0.0041 16.8 0.0 1.5 1 0 0 1 1 1 1 Beta-galactosidase C-terminal domain Cellulase PF00150.18 ETS59534.1 - 0.0052 16.2 0.3 0.014 14.8 0.3 1.7 1 1 1 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 ETS59534.1 - 0.022 14.4 0.7 0.14 11.8 0.7 2.1 1 1 0 1 1 1 0 Glycosyl hydrolases family 35 DUF4434 PF14488.6 ETS59534.1 - 0.096 12.7 0.2 0.56 10.2 0.2 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4434) Na_H_Exchanger PF00999.21 ETS59535.1 - 1.8e-44 152.1 16.4 2.6e-44 151.6 16.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Xin PF08043.12 ETS59535.1 - 0.63 9.8 2.2 1.6 8.4 2.2 1.7 1 0 0 1 1 1 0 Xin repeat DUF417 PF04224.12 ETS59535.1 - 2.6 7.6 5.9 16 5.0 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF417 Nas2_N PF18265.1 ETS59536.1 - 2.8e-18 65.6 0.2 5.3e-18 64.7 0.2 1.5 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_2 PF13180.6 ETS59536.1 - 8.3e-07 29.3 0.0 1.8e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETS59536.1 - 1.8e-06 27.7 0.4 6.4e-06 25.9 0.4 2.0 1 0 0 1 1 1 1 PDZ domain GRASP55_65 PF04495.14 ETS59536.1 - 1.9e-06 28.2 0.0 2.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ PF00595.24 ETS59536.1 - 0.0015 18.8 0.1 0.013 15.9 0.0 2.3 1 1 1 2 2 2 1 PDZ domain ABATE PF07336.11 ETS59536.1 - 0.014 16.1 6.1 0.026 15.2 6.1 1.6 1 1 0 1 1 1 0 Putative stress-induced transcription regulator Abhydrolase_1 PF00561.20 ETS59537.1 - 2.8e-09 37.0 0.0 8.3e-09 35.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS59537.1 - 0.19 11.0 0.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 FAM199X PF15814.5 ETS59538.1 - 0.042 12.9 0.7 0.052 12.6 0.7 1.2 1 0 0 1 1 1 0 Protein family FAM199X Miga PF10265.9 ETS59539.1 - 3.2 6.6 6.0 4.3 6.2 6.0 1.1 1 0 0 1 1 1 0 Mitoguardin Chromate_transp PF02417.15 ETS59540.1 - 8e-58 195.0 32.7 2.7e-32 112.1 10.6 2.7 3 0 0 3 3 3 2 Chromate transporter Acetyltransf_3 PF13302.7 ETS59542.1 - 8.6e-09 36.2 0.0 1.2e-08 35.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS59542.1 - 7.5e-06 26.2 0.0 1e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ETS59542.1 - 0.001 19.0 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ETS59542.1 - 0.0013 18.4 0.0 0.0021 17.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ETS59542.1 - 0.068 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_4 PF13420.7 ETS59542.1 - 0.069 13.3 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS59542.1 - 0.12 12.8 0.0 0.21 12.1 0.0 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain HPP PF04982.13 ETS59543.1 - 2.7e-39 134.1 5.9 4.5e-39 133.4 5.9 1.3 1 0 0 1 1 1 1 HPP family p450 PF00067.22 ETS59545.1 - 5.6e-68 229.8 0.0 7.8e-68 229.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 IDEAL PF08858.10 ETS59545.1 - 0.056 13.2 0.2 0.16 11.7 0.1 1.9 2 0 0 2 2 2 0 IDEAL domain bZIP_1 PF00170.21 ETS59547.1 - 2.6e-08 33.9 12.2 1.9e-06 27.8 5.2 2.4 1 1 1 2 2 2 2 bZIP transcription factor Hap4_Hap_bind PF10297.9 ETS59547.1 - 8.1e-08 32.1 3.8 2e-07 30.9 3.8 1.8 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 CpXC PF14353.6 ETS59547.1 - 0.12 12.4 0.2 0.9 9.6 0.0 2.1 2 0 0 2 2 2 0 CpXC protein bZIP_2 PF07716.15 ETS59547.1 - 9.6 6.4 15.9 0.72 10.0 3.2 2.8 3 0 0 3 3 3 0 Basic region leucine zipper NAD_binding_2 PF03446.15 ETS59549.1 - 4e-32 111.6 0.4 5.8e-32 111.0 0.4 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ETS59549.1 - 6.4e-28 97.4 0.3 3.2e-27 95.2 0.0 2.1 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ETS59549.1 - 0.043 14.4 0.4 0.22 12.1 0.2 2.1 1 1 1 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Ribonuclease_3 PF00636.26 ETS59550.1 - 1.9e-10 41.3 0.0 8.3e-10 39.2 0.0 2.2 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ETS59550.1 - 0.033 14.3 0.1 1 9.5 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease-III-like SOBP PF15279.6 ETS59550.1 - 0.2 12.3 5.2 0.4 11.3 4.6 1.7 1 1 0 1 1 1 0 Sine oculis-binding protein DnaJ_CXXCXGXG PF00684.19 ETS59552.1 - 0.028 14.8 5.8 0.12 12.7 1.3 2.3 2 0 0 2 2 2 0 DnaJ central domain Metallophos PF00149.28 ETS59554.1 - 1.1e-18 68.5 0.1 3.4e-18 66.9 0.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ETS59554.1 - 1.3e-14 54.8 0.1 3.1e-14 53.6 0.1 1.7 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 ETS59554.1 - 2.6e-13 50.3 4.4 6.5e-13 49.1 4.4 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 ETS59554.1 - 0.0029 18.1 0.3 0.0068 16.9 0.3 1.6 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain ADD_DNMT3 PF17980.1 ETS59554.1 - 0.18 11.8 0.1 1.3 9.1 0.1 2.1 2 0 0 2 2 2 0 Cysteine rich ADD domain in DNMT3 NotI PF12183.8 ETS59556.1 - 0.05 12.9 0.0 0.054 12.8 0.0 1.1 1 0 0 1 1 1 0 Restriction endonuclease NotI Prefoldin PF02996.17 ETS59557.1 - 5.7e-11 42.4 0.3 8.7e-11 41.8 0.3 1.4 1 0 0 1 1 1 1 Prefoldin subunit DASH_Dad3 PF08656.10 ETS59557.1 - 0.044 13.9 2.6 0.6 10.2 2.6 2.4 1 1 0 1 1 1 0 DASH complex subunit Dad3 FliT PF05400.13 ETS59557.1 - 0.18 12.7 4.5 1.4 9.8 1.0 2.7 2 1 1 3 3 3 0 Flagellar protein FliT FliD_N PF02465.18 ETS59557.1 - 0.64 10.7 4.2 0.59 10.9 0.2 2.5 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Utp11 PF03998.13 ETS59557.1 - 2.7 7.9 7.8 16 5.4 0.1 2.0 1 1 0 2 2 2 0 Utp11 protein DUF4140 PF13600.6 ETS59557.1 - 5.7 7.5 6.9 12 6.4 3.1 2.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Complex1_LYR PF05347.15 ETS59558.1 - 1.2e-07 31.6 0.1 1.2e-07 31.6 0.1 1.5 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ETS59558.1 - 0.0041 17.8 0.7 0.0094 16.7 0.1 1.7 1 1 1 2 2 2 1 Complex1_LYR-like adh_short_C2 PF13561.6 ETS59559.1 - 1.3e-42 146.0 0.0 1.8e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS59559.1 - 4.8e-40 137.1 0.1 8.5e-40 136.3 0.1 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS59559.1 - 4.7e-05 23.4 0.0 8.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF2985 PF11204.8 ETS59560.1 - 1.1e-22 80.0 0.2 1.1e-22 80.0 0.2 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) Herpes_DNAp_acc PF04929.12 ETS59560.1 - 4.5 6.1 7.7 10 5.0 7.7 1.5 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Asp PF00026.23 ETS59562.1 - 4.3e-55 187.3 10.2 9.7e-55 186.2 10.2 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS59562.1 - 1.3e-08 35.3 6.4 0.0026 18.0 0.1 3.6 1 1 2 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS59562.1 - 0.0011 19.6 3.4 0.0055 17.3 0.1 2.9 3 0 0 3 3 3 1 Aspartyl protease PseudoU_synth_2 PF00849.22 ETS59563.1 - 1.6e-24 86.8 0.0 3.4e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase UPF0020 PF01170.18 ETS59563.1 - 2.5e-13 50.1 0.0 7.1e-13 48.7 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 AviRa PF11599.8 ETS59563.1 - 1.9e-08 34.0 0.0 0.0019 17.7 0.0 2.5 1 1 1 2 2 2 2 RRNA methyltransferase AviRa Methyltransf_31 PF13847.6 ETS59563.1 - 4.7e-05 23.2 0.0 9.7e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS59563.1 - 0.0037 17.9 0.0 0.0095 16.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Complex1_LYR_2 PF13233.6 ETS59564.1 - 1.6e-20 73.6 0.8 3.1e-20 72.7 0.8 1.7 1 1 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ETS59564.1 - 7.1e-13 48.4 0.1 1.6e-12 47.2 0.1 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) His_Phos_2 PF00328.22 ETS59565.1 - 5e-23 82.1 0.0 9e-15 54.9 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Hexokinase_2 PF03727.16 ETS59566.1 - 7.1e-86 287.5 0.1 9.9e-86 287.1 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ETS59566.1 - 6.9e-73 244.8 0.0 9.6e-73 244.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Gly-zipper_Omp PF13488.6 ETS59566.1 - 1.2 9.2 6.0 7.5 6.6 0.9 2.6 2 0 0 2 2 2 0 Glycine zipper Epimerase PF01370.21 ETS59567.1 - 2.1e-21 76.5 0.0 5.3e-21 75.2 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS59567.1 - 1.7e-11 43.7 0.0 7.8e-11 41.5 0.0 2.0 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ETS59567.1 - 1.7e-11 43.8 0.0 2.4e-10 40.0 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ETS59567.1 - 2.5e-11 43.8 0.0 1.2e-10 41.6 0.0 2.1 2 0 0 2 2 2 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ETS59567.1 - 2.5e-07 30.1 0.0 0.00014 21.1 0.0 2.3 2 0 0 2 2 2 2 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ETS59567.1 - 6.5e-06 25.8 0.0 1.4e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ETS59567.1 - 0.00063 20.0 0.0 0.0014 18.9 0.0 1.6 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 ETS59567.1 - 0.0085 15.7 0.0 0.45 10.0 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family Polysacc_synt_2 PF02719.15 ETS59567.1 - 0.034 13.3 0.0 0.05 12.7 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein WH2 PF02205.20 ETS59567.1 - 0.097 12.5 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 WH2 motif SET PF00856.28 ETS59568.1 - 0.0069 16.8 0.0 0.029 14.8 0.0 2.1 2 1 0 2 2 2 1 SET domain MIP PF00230.20 ETS59569.1 - 5.6e-23 81.8 9.7 8.7e-23 81.2 9.7 1.2 1 0 0 1 1 1 1 Major intrinsic protein Pkinase PF00069.25 ETS59570.1 - 1.3e-37 129.7 0.0 3.7e-21 75.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59570.1 - 9.9e-15 54.5 0.0 3.4e-10 39.7 0.0 2.9 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS59570.1 - 0.00022 20.7 0.0 0.28 10.5 0.0 2.1 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ETS59570.1 - 0.048 13.6 0.0 0.26 11.2 0.0 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Abhydrolase_3 PF07859.13 ETS59571.1 - 8.5e-22 78.1 0.5 8.8e-21 74.7 0.5 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS59571.1 - 4.8e-08 33.9 0.3 6.2e-08 33.5 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ETS59571.1 - 1.5e-06 27.8 0.5 0.00029 20.4 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.28 ETS59571.1 - 0.0033 16.4 0.0 0.011 14.7 0.0 1.8 3 0 0 3 3 3 1 Carboxylesterase family Esterase_phd PF10503.9 ETS59571.1 - 0.031 13.8 0.0 0.52 9.8 0.0 2.2 2 0 0 2 2 2 0 Esterase PHB depolymerase LIP PF03583.14 ETS59571.1 - 0.089 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Secretory lipase Abhydrolase_2 PF02230.16 ETS59571.1 - 0.11 12.3 0.0 2 8.1 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DLH PF01738.18 ETS59571.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF202 PF02656.15 ETS59572.1 - 7e-05 23.2 4.0 0.00043 20.7 0.3 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF202) RCC1 PF00415.18 ETS59574.1 - 5.4e-20 71.8 9.9 0.00034 21.2 0.0 7.1 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETS59574.1 - 2.8e-07 30.2 27.6 0.09 12.6 0.2 7.9 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Sigma70_r4_2 PF08281.12 ETS59574.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 Pyr_redox_2 PF07992.14 ETS59575.1 - 1.5e-49 168.8 0.0 1.9e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS59575.1 - 1.5e-11 44.7 0.0 1.7e-10 41.3 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS59575.1 - 0.0024 17.2 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase TPPII_N PF12583.8 ETS59575.1 - 0.054 14.1 0.0 0.19 12.3 0.0 1.9 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal NAD_binding_7 PF13241.6 ETS59575.1 - 0.075 13.5 0.1 3 8.3 0.0 2.6 2 1 0 2 2 2 0 Putative NAD(P)-binding DAO PF01266.24 ETS59575.1 - 0.1 12.2 0.2 25 4.3 0.0 3.0 3 0 0 3 3 3 0 FAD dependent oxidoreductase Acetyltransf_3 PF13302.7 ETS59577.1 - 1.8e-20 74.1 0.0 2.3e-20 73.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS59577.1 - 7.1e-05 23.0 0.0 9.7e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family AstA PF04958.12 ETS59577.1 - 0.004 15.8 0.0 0.006 15.2 0.0 1.1 1 0 0 1 1 1 1 Arginine N-succinyltransferase beta subunit C2 PF00168.30 ETS59578.1 - 5.3e-23 81.3 0.0 4.1e-14 52.7 0.0 2.5 2 0 0 2 2 2 2 C2 domain MMM1 PF10296.9 ETS59578.1 - 0.0052 15.9 0.0 0.013 14.6 0.0 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 zf-TRAF PF02176.18 ETS59579.1 - 3.3e-09 37.3 16.7 5.8e-07 30.1 1.9 5.2 3 1 3 6 6 6 3 TRAF-type zinc finger zf-RING_UBOX PF13445.6 ETS59579.1 - 3.5e-07 30.1 7.5 1.5e-06 28.1 7.5 2.2 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETS59579.1 - 5.8e-06 26.0 8.1 5.8e-06 26.0 8.1 4.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS59579.1 - 5.9e-06 26.2 9.2 5.9e-06 26.2 9.2 3.0 3 1 0 3 3 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETS59579.1 - 7.7e-05 22.9 10.3 7.7e-05 22.9 10.3 4.1 3 1 1 4 4 3 1 Ring finger domain zf-Nse PF11789.8 ETS59579.1 - 0.00018 21.2 9.9 0.00023 20.9 4.6 2.7 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4 PF00097.25 ETS59579.1 - 0.00047 20.0 9.1 0.00047 20.0 9.1 3.8 4 1 0 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETS59579.1 - 0.022 14.9 9.4 0.022 14.9 9.4 2.8 2 1 0 2 2 1 0 zinc finger of C3HC4-type, RING HALZ PF02183.18 ETS59579.1 - 0.046 14.0 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper bZIP_1 PF00170.21 ETS59579.1 - 0.14 12.3 0.1 0.63 10.2 0.0 2.1 2 0 0 2 2 2 0 bZIP transcription factor zf-ANAPC11 PF12861.7 ETS59579.1 - 0.54 10.3 5.9 3 8.0 5.9 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rod_cone_degen PF15201.6 ETS59579.1 - 3.2 7.9 5.5 20 5.3 0.2 2.7 2 0 0 2 2 2 0 Progressive rod-cone degeneration Sina PF03145.16 ETS59579.1 - 5.1 7.0 22.8 0.15 12.0 0.6 3.9 2 1 3 5 5 5 0 Seven in absentia protein family zf-RING_6 PF14835.6 ETS59579.1 - 9.1 6.2 10.5 0.17 11.8 2.9 2.1 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Aa_trans PF01490.18 ETS59580.1 - 1.5e-61 208.4 11.2 1.8e-61 208.1 11.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ETS59580.1 - 0.00038 19.6 9.5 0.00038 19.6 9.5 1.8 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Peptidase_M20 PF01546.28 ETS59582.1 - 1.2e-35 123.2 0.0 1.5e-35 122.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETS59582.1 - 1.4e-10 41.1 0.0 4.8e-10 39.3 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Sedlin_N PF04628.13 ETS59583.1 - 4.5e-20 72.1 0.0 5.5e-19 68.6 0.0 1.9 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region FAD_binding_7 PF03441.14 ETS59584.1 - 1.9e-66 223.4 0.0 2.7e-66 222.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 ETS59584.1 - 7.6e-39 133.3 0.1 1.3e-38 132.5 0.1 1.4 1 0 0 1 1 1 1 DNA photolyase MMgT PF10270.9 ETS59585.1 - 1e-17 64.3 0.1 1.2e-17 64.0 0.1 1.1 1 0 0 1 1 1 1 Membrane magnesium transporter AA_permease_2 PF13520.6 ETS59586.1 - 8.7e-58 196.1 55.3 1.1e-57 195.8 55.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS59586.1 - 3.3e-33 115.0 49.4 4.3e-33 114.6 49.4 1.0 1 0 0 1 1 1 1 Amino acid permease DUF2905 PF11146.8 ETS59586.1 - 0.38 11.0 6.8 1.3 9.2 3.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2905) DUF2614 PF11023.8 ETS59586.1 - 3.2 7.9 6.1 3.7 7.7 0.5 3.1 2 1 0 2 2 2 0 Zinc-ribbon containing domain ABC_tran PF00005.27 ETS59587.1 - 6.9e-43 146.4 0.3 1.4e-21 77.4 0.0 4.2 3 1 0 3 3 3 2 ABC transporter SMC_N PF02463.19 ETS59587.1 - 7.2e-12 45.2 0.0 0.00011 21.8 0.0 3.7 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETS59587.1 - 1.8e-10 41.1 11.3 0.0019 18.1 2.9 4.4 2 2 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETS59587.1 - 2.9e-09 36.5 0.2 0.0012 18.5 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ETS59587.1 - 5.6e-07 29.7 1.9 0.0016 18.5 0.1 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS59587.1 - 2.3e-06 27.6 0.7 0.034 14.0 0.0 3.4 3 0 0 3 3 3 1 RsgA GTPase AAA_30 PF13604.6 ETS59587.1 - 1.2e-05 25.2 14.8 0.00014 21.7 0.1 4.6 4 1 0 4 4 4 2 AAA domain NACHT PF05729.12 ETS59587.1 - 2.1e-05 24.5 0.0 0.2 11.6 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_22 PF13401.6 ETS59587.1 - 4.1e-05 23.9 0.3 0.14 12.5 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ETS59587.1 - 6.2e-05 23.6 14.5 0.0025 18.3 0.0 3.7 4 1 1 5 5 3 2 AAA domain AAA_28 PF13521.6 ETS59587.1 - 0.0001 22.6 0.3 0.17 12.1 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETS59587.1 - 0.00011 22.6 3.5 0.066 13.6 0.0 3.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 ETS59587.1 - 0.00011 22.0 1.1 0.74 9.5 0.0 3.1 3 0 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 ETS59587.1 - 0.00014 22.3 0.0 0.63 10.5 0.0 3.5 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) ABC_tran_Xtn PF12848.7 ETS59587.1 - 0.00037 20.5 6.2 0.00037 20.5 6.2 2.2 2 0 0 2 2 1 1 ABC transporter AAA_19 PF13245.6 ETS59587.1 - 0.00039 20.8 0.6 0.33 11.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 ETS59587.1 - 0.00051 19.3 0.0 0.7 9.0 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_7 PF12775.7 ETS59587.1 - 0.00076 19.0 0.0 0.96 8.9 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_27 PF13514.6 ETS59587.1 - 0.00087 18.9 1.8 0.26 10.8 0.0 3.3 3 0 0 3 3 2 1 AAA domain Dynamin_N PF00350.23 ETS59587.1 - 0.0016 18.5 0.1 0.22 11.6 0.0 2.9 2 0 0 2 2 2 1 Dynamin family IstB_IS21 PF01695.17 ETS59587.1 - 0.0019 18.0 0.8 1.4 8.6 0.0 2.9 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_14 PF13173.6 ETS59587.1 - 0.0041 17.2 0.0 3.4 7.7 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 ETS59587.1 - 0.0041 16.9 0.6 1.4 8.6 0.1 2.9 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.14 ETS59587.1 - 0.0051 16.8 1.7 7 6.6 0.2 3.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ETS59587.1 - 0.0052 17.2 0.0 2.2 8.7 0.0 2.6 2 0 0 2 2 2 1 RNA helicase MobB PF03205.14 ETS59587.1 - 0.0092 15.9 0.4 0.75 9.7 0.0 2.7 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 ETS59587.1 - 0.012 15.5 0.7 1.7 8.5 0.0 3.2 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 ETS59587.1 - 0.016 14.8 1.4 4.1 6.9 0.3 3.1 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 ETS59587.1 - 0.021 15.0 0.0 1.6 9.0 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATP-grasp_3 PF02655.14 ETS59587.1 - 0.024 14.7 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ABC_ATPase PF09818.9 ETS59587.1 - 0.028 13.2 5.2 0.19 10.5 0.1 2.8 3 0 0 3 3 3 0 Predicted ATPase of the ABC class SRP54 PF00448.22 ETS59587.1 - 0.035 13.8 0.0 2 8.0 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 ETS59587.1 - 0.052 13.7 4.6 1.9 8.6 0.0 3.5 3 1 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 ETS59587.1 - 0.052 13.8 0.0 0.39 11.0 0.0 2.4 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit NTPase_1 PF03266.15 ETS59587.1 - 0.053 13.4 3.4 1.6 8.6 0.1 2.9 3 0 0 3 3 2 0 NTPase MukB PF04310.12 ETS59587.1 - 0.057 13.2 0.3 4.8 6.9 0.0 2.4 2 0 0 2 2 2 0 MukB N-terminal zf-met2 PF12907.7 ETS59587.1 - 0.063 13.4 0.7 0.13 12.4 0.7 1.4 1 0 0 1 1 1 0 Zinc-binding Septin PF00735.18 ETS59587.1 - 0.073 12.3 0.1 1.1 8.5 0.0 2.3 2 0 0 2 2 2 0 Septin Mg_chelatase PF01078.21 ETS59587.1 - 0.1 12.0 0.2 2.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI MeaB PF03308.16 ETS59587.1 - 0.11 11.5 8.1 2.6 6.9 0.1 4.0 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 ETS59587.1 - 0.17 11.5 2.4 1.4 8.5 0.1 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 ETS59587.1 - 0.93 8.8 5.3 2.4 7.4 0.0 2.8 3 0 0 3 3 2 0 FtsK/SpoIIIE family FAM25 PF15825.5 ETS59587.1 - 1.1 9.7 8.2 0.3 11.5 1.3 2.8 2 0 0 2 2 2 0 FAM25 family Presenilin PF01080.17 ETS59587.1 - 4.6 5.9 8.2 0.098 11.4 0.7 1.8 2 0 0 2 2 2 0 Presenilin AAA_18 PF13238.6 ETS59587.1 - 9.9 6.7 9.6 11 6.5 2.6 3.3 3 1 0 3 3 2 0 AAA domain F-box-like PF12937.7 ETS59588.1 - 8.4e-11 41.6 0.1 2.4e-10 40.1 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETS59588.1 - 3.8e-07 29.8 0.0 1e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 F-box domain TPR_9 PF13371.6 ETS59588.1 - 2.1e-05 24.6 4.0 5.6e-05 23.2 0.3 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETS59588.1 - 0.0001 22.1 2.3 0.043 13.9 0.7 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETS59588.1 - 0.0008 19.1 1.5 0.015 15.1 0.4 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat F-box_4 PF15966.5 ETS59588.1 - 0.0089 15.9 0.2 0.023 14.6 0.2 1.7 1 0 0 1 1 1 1 F-box TPR_19 PF14559.6 ETS59588.1 - 0.012 16.1 0.2 0.012 16.1 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETS59588.1 - 0.023 14.9 0.7 1.5 9.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat ADH_N PF08240.12 ETS59589.1 - 7.7e-27 93.3 2.3 1.9e-26 92.1 2.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS59589.1 - 6.5e-23 81.1 0.1 9.6e-23 80.6 0.1 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ETS59589.1 - 3.1e-11 43.2 0.1 1.2e-05 24.9 0.0 2.3 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ETS59589.1 - 0.00084 20.4 0.0 0.0025 18.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Pyr_redox_2 PF07992.14 ETS59589.1 - 0.033 13.4 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1495 PF07381.11 ETS59589.1 - 0.064 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) UDPG_MGDP_dh_N PF03721.14 ETS59589.1 - 0.096 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AA_permease_2 PF13520.6 ETS59590.1 - 1.1e-70 238.6 53.8 1.4e-70 238.3 53.8 1.1 1 0 0 1 1 1 1 Amino acid permease UPF0020 PF01170.18 ETS59591.1 - 5.8e-07 29.4 0.2 6.3e-06 26.0 0.2 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 ETS59591.1 - 0.15 11.3 0.0 0.94 8.7 0.0 1.9 2 0 0 2 2 2 0 N-6 DNA Methylase Acetyltransf_7 PF13508.7 ETS59592.1 - 0.0001 22.6 0.0 0.00019 21.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS59592.1 - 0.053 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FAD_binding_4 PF01565.23 ETS59593.1 - 3e-21 75.6 2.5 5.3e-21 74.8 2.5 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ETS59593.1 - 0.0043 17.1 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like Lactonase PF10282.9 ETS59594.1 - 5.8e-20 71.8 0.0 3.4e-16 59.4 0.0 2.4 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller SGL PF08450.12 ETS59594.1 - 0.019 14.6 0.0 0.051 13.2 0.0 1.7 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region His_Phos_1 PF00300.22 ETS59600.1 - 7.5e-37 126.9 0.7 1e-36 126.5 0.1 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Peptidase_M50B PF13398.6 ETS59601.1 - 1.3e-62 211.0 15.7 1.7e-62 210.7 15.7 1.1 1 0 0 1 1 1 1 Peptidase M50B-like DAGK_prokar PF01219.19 ETS59601.1 - 1.3 8.9 7.1 0.67 9.8 2.3 2.4 2 0 0 2 2 2 0 Prokaryotic diacylglycerol kinase Phage_holin_5_1 PF06946.11 ETS59602.1 - 0.056 13.8 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Bacteriophage A118-like holin, Hol118 Alpha_Helical PF18489.1 ETS59602.1 - 0.14 12.4 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Alpha helical domain UPF0029 PF01205.19 ETS59603.1 - 2.4e-32 111.4 0.0 5.3e-32 110.3 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 ETS59603.1 - 1.8e-07 31.4 0.0 7.3e-07 29.5 0.0 2.0 1 1 0 1 1 1 1 RWD domain Inhibitor_I9 PF05922.16 ETS59604.1 - 4.7e-06 27.2 0.1 1.1e-05 25.9 0.1 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I9 Thioredoxin PF00085.20 ETS59605.1 - 0.012 15.6 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin DUF3246 PF11596.8 ETS59605.1 - 1.1 8.6 5.3 2 7.8 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Cwf_Cwc_15 PF04889.12 ETS59605.1 - 1.5 8.5 10.2 0.31 10.8 6.7 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Rhomboid PF01694.22 ETS59606.1 - 1.1e-26 93.6 4.0 2.1e-26 92.7 4.0 1.5 1 0 0 1 1 1 1 Rhomboid family Pyridoxal_deC PF00282.19 ETS59607.1 - 2.9e-66 223.7 0.0 5.4e-66 222.8 0.0 1.4 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain DUF155 PF02582.14 ETS59607.1 - 1.1e-48 165.7 0.0 1.9e-48 164.9 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Beta_elim_lyase PF01212.21 ETS59607.1 - 0.00055 19.3 0.0 0.0017 17.7 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ETS59607.1 - 0.00076 18.5 0.0 0.0026 16.8 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class-V Methyltransf_25 PF13649.6 ETS59608.1 - 4.5e-19 69.0 0.0 3.6e-18 66.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS59608.1 - 2e-18 66.7 0.0 4.4e-18 65.5 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS59608.1 - 1.8e-17 63.7 0.0 2e-16 60.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS59608.1 - 1.6e-15 57.7 0.0 2.6e-14 53.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS59608.1 - 1.1e-12 47.9 0.0 2.4e-12 46.7 0.0 1.5 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ETS59608.1 - 1.2e-10 41.5 0.0 1.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS59608.1 - 1.2e-09 38.0 0.0 1.7e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 ETS59608.1 - 4.3e-08 33.2 0.0 5.7e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 ETS59608.1 - 1.5e-05 25.0 0.0 2.3e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETS59608.1 - 1.7e-05 24.3 0.0 2.4e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ETS59608.1 - 0.0003 20.3 0.0 0.00043 19.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) GCD14 PF08704.10 ETS59608.1 - 0.00081 19.1 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_4 PF02390.17 ETS59608.1 - 0.00086 18.8 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase DOT1 PF08123.13 ETS59608.1 - 0.0097 15.5 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 UPF0020 PF01170.18 ETS59608.1 - 0.023 14.4 0.1 0.14 11.9 0.1 2.0 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Fibrillarin PF01269.17 ETS59608.1 - 0.032 13.3 0.1 0.12 11.4 0.0 1.9 2 0 0 2 2 2 0 Fibrillarin Methyltransf_18 PF12847.7 ETS59608.1 - 0.049 13.6 0.0 0.098 12.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain N6_Mtase PF02384.16 ETS59608.1 - 0.085 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase MetW PF07021.12 ETS59608.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RrnaAD PF00398.20 ETS59608.1 - 0.13 11.3 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DEAD PF00270.29 ETS59609.1 - 2.3e-25 89.4 0.0 3.7e-25 88.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 ETS59609.1 - 1.4e-18 67.4 1.0 4.7e-18 65.7 1.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 ETS59609.1 - 5.1e-14 52.6 0.1 2.2e-13 50.5 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS59609.1 - 1.3e-06 28.5 0.0 2.3e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 ETS59609.1 - 6e-06 26.7 0.0 1.4e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 DNA replication factor CDT1 like T2SSE PF00437.20 ETS59609.1 - 0.067 12.2 0.0 0.17 11.0 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein G10 PF01125.17 ETS59610.1 - 4.3e-33 114.1 0.5 5.3e-33 113.8 0.5 1.1 1 0 0 1 1 1 1 G10 protein DUF5347 PF17282.2 ETS59610.1 - 0.1 12.9 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5347) Pkinase PF00069.25 ETS59611.1 - 3.6e-69 233.1 0.1 2.3e-60 204.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59611.1 - 8.7e-31 107.1 0.0 7.1e-26 91.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS59611.1 - 0.00019 20.9 2.2 2 7.6 0.1 3.2 3 0 0 3 3 3 3 Kinase-like RIO1 PF01163.22 ETS59611.1 - 0.08 12.5 1.1 1.8 8.1 0.3 2.2 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 ETS59611.1 - 0.087 12.7 8.5 0.38 10.6 0.0 3.1 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETS59611.1 - 0.13 11.0 0.0 0.13 11.0 0.0 2.0 3 0 0 3 3 3 0 Fungal protein kinase Med3 PF11593.8 ETS59611.1 - 0.82 8.8 22.3 2.6 7.1 13.9 2.4 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal TILa PF12714.7 ETS59612.1 - 0.24 11.4 3.8 0.083 12.9 0.9 1.7 2 0 0 2 2 2 0 TILa domain G_glu_transpept PF01019.21 ETS59613.1 - 1.6e-138 462.7 2.1 6e-137 457.5 2.1 2.0 1 1 0 1 1 1 1 Gamma-glutamyltranspeptidase GST_N_3 PF13417.6 ETS59615.1 - 0.002 18.5 0.0 0.0042 17.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETS59615.1 - 0.0082 16.3 0.0 0.031 14.5 0.0 1.9 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETS59615.1 - 0.018 15.3 0.0 0.053 13.8 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ETS59615.1 - 0.043 14.1 0.0 0.1 12.9 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Lipase_3 PF01764.25 ETS59617.1 - 4.4e-16 59.0 0.0 8.4e-16 58.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) MR_MLE_C PF13378.6 ETS59618.1 - 4.4e-47 160.5 0.9 4.2e-46 157.3 0.7 2.3 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ETS59618.1 - 0.00034 20.8 0.0 0.00074 19.7 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 ETS59618.1 - 0.0062 15.7 0.0 0.0097 15.1 0.0 1.2 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Abhydrolase_3 PF07859.13 ETS59619.1 - 7.7e-11 42.2 0.0 4.3e-10 39.8 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS59619.1 - 4.4e-07 30.7 5.8 6.3e-07 30.2 5.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ETS59619.1 - 6.2e-05 22.6 0.1 0.00082 18.9 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ETS59619.1 - 0.021 14.5 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 ETS59619.1 - 0.085 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme LIP PF03583.14 ETS59619.1 - 0.097 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Secretory lipase COesterase PF00135.28 ETS59619.1 - 0.25 10.1 0.0 0.34 9.7 0.0 1.2 1 0 0 1 1 1 0 Carboxylesterase family LysM PF01476.20 ETS59620.1 - 1e-12 47.9 0.0 3.3e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 LysM domain DUF4778 PF16008.5 ETS59620.1 - 0.48 10.4 11.5 0.67 10.0 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) TFIIA PF03153.13 ETS59620.1 - 0.51 10.3 25.3 0.58 10.1 25.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit KOG2701 PF09762.9 ETS59620.1 - 3.1 8.0 9.2 5.5 7.2 9.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein (DUF2037) PCRF PF03462.18 ETS59621.1 - 2.5e-40 138.4 0.5 6.5e-40 137.1 0.5 1.7 1 0 0 1 1 1 1 PCRF domain RF-1 PF00472.20 ETS59621.1 - 5.3e-36 123.1 2.0 1.5e-35 121.6 2.0 1.8 1 0 0 1 1 1 1 RF-1 domain HLH PF00010.26 ETS59622.1 - 4.6e-09 36.1 0.0 1.5e-08 34.4 0.0 1.9 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF5094 PF17015.5 ETS59622.1 - 0.15 12.2 1.9 0.24 11.5 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) DUF4097 PF13349.6 ETS59624.1 - 0.0019 17.6 0.1 0.0039 16.6 0.0 1.5 2 0 0 2 2 2 1 Putative adhesin ECH_1 PF00378.20 ETS59628.1 - 3.9e-42 144.3 0.1 1.8e-40 138.9 0.1 2.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS59628.1 - 4.2e-25 89.0 1.1 2e-23 83.4 0.3 2.5 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase PS_Dcarbxylase PF02666.15 ETS59629.1 - 1.2e-73 246.9 0.0 1.5e-55 187.9 0.0 2.2 2 0 0 2 2 2 2 Phosphatidylserine decarboxylase Pmp3 PF01679.17 ETS59629.1 - 8.7e-24 83.5 11.8 1.5e-23 82.7 11.8 1.4 1 0 0 1 1 1 1 Proteolipid membrane potential modulator NADH_oxidored PF08040.11 ETS59629.1 - 0.071 12.8 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 MNLL subunit Nnf1 PF03980.14 ETS59630.1 - 1e-13 51.6 8.6 1e-13 51.6 8.6 2.6 1 1 0 2 2 2 1 Nnf1 Filament PF00038.21 ETS59630.1 - 0.00061 19.5 8.5 0.00061 19.5 8.5 2.0 2 1 0 2 2 2 1 Intermediate filament protein Dynein_C PF18199.1 ETS59630.1 - 0.0012 18.1 1.2 0.0019 17.5 1.2 1.3 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain TolA_bind_tri PF16331.5 ETS59630.1 - 0.0019 18.3 8.0 0.0019 18.3 8.0 2.8 2 1 1 3 3 3 1 TolA binding protein trimerisation DUF2968 PF11180.8 ETS59630.1 - 0.0045 16.6 11.3 0.0045 16.6 11.3 2.4 2 1 1 3 3 3 1 Protein of unknown function (DUF2968) Fib_alpha PF08702.10 ETS59630.1 - 0.057 13.6 3.7 0.09 13.0 2.4 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 ETS59630.1 - 0.22 11.6 7.3 0.32 11.0 5.7 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FapA PF03961.13 ETS59630.1 - 0.23 10.0 5.3 0.36 9.4 5.3 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A Snapin_Pallidin PF14712.6 ETS59630.1 - 0.47 10.9 10.9 2 8.9 1.5 3.5 3 0 0 3 3 3 0 Snapin/Pallidin Laminin_II PF06009.12 ETS59630.1 - 0.7 9.9 9.7 0.066 13.2 3.5 2.4 2 1 1 3 3 3 0 Laminin Domain II FlaC_arch PF05377.11 ETS59630.1 - 1 9.8 4.6 7.8 7.0 0.2 3.7 3 1 0 4 4 4 0 Flagella accessory protein C (FlaC) DivIVA PF05103.13 ETS59630.1 - 1.7 8.7 14.5 0.042 13.9 4.2 2.8 3 0 0 3 3 3 0 DivIVA protein DUF3037 PF11236.8 ETS59630.1 - 4.3 7.8 6.3 2.3 8.7 1.2 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3037) Spc7 PF08317.11 ETS59630.1 - 6.3 5.6 18.1 0.34 9.8 12.6 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 ETS59630.1 - 9.9 6.5 7.4 2.8 8.3 2.6 2.5 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Ank_2 PF12796.7 ETS59631.1 - 1.3e-40 137.8 1.5 5.1e-16 59.0 0.1 2.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETS59631.1 - 3.1e-26 91.1 0.6 2.4e-10 40.4 0.0 4.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETS59631.1 - 3.3e-23 81.7 0.6 4.1e-13 49.6 0.1 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) FYVE PF01363.21 ETS59631.1 - 7.3e-20 70.9 6.3 7.3e-20 70.9 6.3 3.0 3 0 0 3 3 3 1 FYVE zinc finger Ank_3 PF13606.6 ETS59631.1 - 1.5e-16 58.8 0.1 0.00096 19.4 0.0 5.0 4 0 0 4 4 4 4 Ankyrin repeat Ank PF00023.30 ETS59631.1 - 2.9e-16 59.1 0.5 0.0011 19.3 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat zf-RING_2 PF13639.6 ETS59631.1 - 5e-08 33.2 4.0 5e-08 33.2 4.0 3.5 3 0 0 3 3 3 1 Ring finger domain zf-RING_11 PF17123.5 ETS59631.1 - 0.00026 20.6 4.5 0.00026 20.6 4.5 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETS59631.1 - 0.00037 20.3 2.7 0.00037 20.3 2.7 3.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS59631.1 - 0.0034 17.4 4.0 0.0034 17.4 4.0 2.7 3 0 0 3 3 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 ETS59631.1 - 0.015 15.6 2.3 0.015 15.6 2.3 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain RINGv PF12906.7 ETS59631.1 - 0.16 12.1 3.0 0.57 10.3 3.0 2.0 1 0 0 1 1 1 0 RING-variant domain PAM2 PF07145.15 ETS59631.1 - 0.21 11.4 0.8 0.6 9.9 0.8 1.8 1 0 0 1 1 1 0 Ataxin-2 C-terminal region FANCL_C PF11793.8 ETS59631.1 - 0.44 10.7 5.5 0.23 11.6 2.2 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain Cwf_Cwc_15 PF04889.12 ETS59631.1 - 7.2 6.3 28.0 1.9 8.1 15.1 3.0 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein Hist_deacetyl PF00850.19 ETS59633.1 - 6.8e-88 295.1 0.0 1.1e-87 294.4 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Arb2 PF09757.9 ETS59633.1 - 1.5e-32 112.8 0.0 2.4e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Arb2 domain UPF0565 PF10561.9 ETS59633.1 - 0.021 14.1 0.0 0.034 13.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DUF3530 PF12048.8 ETS59633.1 - 0.2 11.1 0.3 2.9 7.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) FIST PF08495.10 ETS59634.1 - 1.3e-05 25.2 0.0 8.6e-05 22.6 0.0 2.0 1 1 1 2 2 2 1 FIST N domain Arf PF00025.21 ETS59635.1 - 3.4e-14 52.7 0.0 1.1e-10 41.2 0.0 3.0 3 0 0 3 3 3 2 ADP-ribosylation factor family Roc PF08477.13 ETS59635.1 - 2.3e-08 34.3 0.1 0.0001 22.5 0.0 2.6 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ETS59635.1 - 6.9e-05 22.2 0.0 0.00035 19.9 0.0 1.8 2 0 0 2 2 2 1 G-protein alpha subunit Ras PF00071.22 ETS59635.1 - 0.0011 18.6 0.0 4.4 6.9 0.1 3.0 3 0 0 3 3 3 2 Ras family Apc13p PF05839.11 ETS59635.1 - 0.0049 17.0 0.0 0.033 14.4 0.0 2.1 2 0 0 2 2 2 1 Apc13p protein AAA_16 PF13191.6 ETS59635.1 - 0.011 16.1 0.0 0.033 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ETS59635.1 - 0.016 15.1 0.0 0.4 10.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 ETS59635.1 - 0.061 13.4 0.0 0.12 12.5 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ETS59635.1 - 0.07 12.9 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 ETS59635.1 - 0.071 13.0 0.3 0.43 10.5 0.3 2.1 1 1 0 1 1 1 0 NACHT domain 3HCDH_N PF02737.18 ETS59636.1 - 7.8e-45 153.0 4.0 6.5e-44 150.0 4.0 2.0 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ETS59636.1 - 2.2e-33 114.8 0.0 4e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain DAO PF01266.24 ETS59636.1 - 0.14 11.7 0.2 0.19 11.2 0.2 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase RGS PF00615.19 ETS59637.1 - 6.3e-38 129.7 0.0 2.3e-37 127.9 0.0 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 ETS59637.1 - 3.5e-11 43.0 0.1 0.0028 17.7 0.0 3.5 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) HTH_45 PF14947.6 ETS59637.1 - 0.051 13.6 0.1 2.1 8.4 0.0 2.8 2 0 0 2 2 2 0 Winged helix-turn-helix Lipase_3 PF01764.25 ETS59640.1 - 1.5e-26 93.0 0.0 2.3e-26 92.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Cutinase PF01083.22 ETS59640.1 - 0.009 16.0 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 1 Cutinase Abhydrolase_1 PF00561.20 ETS59640.1 - 0.019 14.7 0.0 0.032 13.9 0.0 1.3 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS59640.1 - 0.021 15.4 2.1 0.021 15.4 2.1 1.6 1 1 1 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS59640.1 - 0.097 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RraA-like PF03737.15 ETS59641.1 - 4.9e-35 120.9 0.0 1.2e-34 119.7 0.0 1.7 1 0 0 1 1 1 1 Aldolase/RraA SAP PF02037.27 ETS59641.1 - 4.6e-09 35.8 0.3 7.8e-09 35.1 0.3 1.4 1 0 0 1 1 1 1 SAP domain DUF1539 PF07560.11 ETS59641.1 - 0.088 12.9 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) UPF0172 PF03665.13 ETS59642.1 - 4e-48 164.0 0.1 4.6e-48 163.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 ETS59642.1 - 0.00099 19.1 0.0 0.0021 18.0 0.0 1.6 1 1 1 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_3 PF17176.4 ETS59642.1 - 0.065 13.5 0.8 0.46 10.8 0.1 2.1 2 0 0 2 2 2 0 tRNA-binding domain TPR_1 PF00515.28 ETS59643.1 - 1.2e-17 62.9 11.1 0.017 14.9 0.0 8.0 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETS59643.1 - 2.4e-17 61.6 23.6 0.067 13.3 0.0 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETS59643.1 - 3.4e-13 49.0 7.4 0.34 10.6 0.6 6.7 4 2 2 6 6 6 5 TPR repeat TPR_14 PF13428.6 ETS59643.1 - 4.1e-13 48.9 30.9 0.04 14.8 0.0 9.5 4 1 4 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETS59643.1 - 1.8e-12 46.4 7.5 0.0061 16.7 0.1 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETS59643.1 - 7e-08 32.3 3.5 0.95 10.0 0.0 6.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS59643.1 - 1.5e-07 31.9 42.8 0.0023 18.6 0.2 7.9 5 1 5 10 10 9 6 Tetratricopeptide repeat TPR_12 PF13424.6 ETS59643.1 - 0.00096 19.4 33.1 0.0063 16.8 3.1 7.2 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETS59643.1 - 0.002 18.3 3.2 0.002 18.3 3.2 5.8 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS59643.1 - 0.0021 18.5 25.1 0.54 10.8 0.0 7.5 7 1 0 7 7 7 3 Tetratricopeptide repeat Macoilin PF09726.9 ETS59643.1 - 1.9 7.0 10.9 3.4 6.1 10.9 1.4 1 0 0 1 1 1 0 Macoilin family ADK PF00406.22 ETS59644.1 - 3.6e-57 192.7 0.0 4.7e-57 192.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETS59644.1 - 1.8e-22 80.2 0.2 4.9e-22 78.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 ETS59644.1 - 9.5e-17 60.7 0.0 2.2e-16 59.6 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 ETS59644.1 - 0.00038 20.6 0.0 0.00078 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETS59644.1 - 0.00075 20.0 0.0 0.0028 18.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETS59644.1 - 0.018 15.5 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Thymidylate_kin PF02223.17 ETS59644.1 - 0.034 13.8 0.0 2.1 8.0 0.0 2.8 3 0 0 3 3 3 0 Thymidylate kinase AAA_5 PF07728.14 ETS59644.1 - 0.064 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) LPP PF04728.13 ETS59644.1 - 0.07 13.5 0.1 0.21 12.0 0.1 1.8 1 0 0 1 1 1 0 Lipoprotein leucine-zipper Fib_alpha PF08702.10 ETS59644.1 - 0.1 12.8 0.1 0.74 10.0 0.0 2.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family He_PIG PF05345.12 ETS59645.1 - 0.00076 19.6 0.0 0.0021 18.2 0.0 1.7 1 0 0 1 1 1 1 Putative Ig domain Arrestin_C PF02752.22 ETS59646.1 - 2.5e-12 47.4 0.0 6.1e-12 46.2 0.0 1.7 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETS59646.1 - 0.071 13.2 0.1 8.2 6.5 0.0 2.6 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Galactosyl_T PF01762.21 ETS59647.1 - 3e-10 40.2 1.5 0.00011 22.0 0.0 3.8 3 1 1 4 4 4 3 Galactosyltransferase SNF2_N PF00176.23 ETS59648.1 - 4.7e-54 183.4 0.0 7.3e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 ETS59648.1 - 2.1e-49 168.2 0.4 4.7e-49 167.0 0.1 1.7 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 ETS59648.1 - 1.7e-15 57.3 0.0 1.5e-14 54.2 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS59648.1 - 1.3e-09 38.3 0.0 2.8e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETS59648.1 - 2.8e-07 30.5 0.1 1.1e-05 25.3 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 ETS59648.1 - 5.4e-06 25.8 0.0 3.5e-05 23.1 0.0 2.2 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 ETS59648.1 - 0.00063 20.0 0.6 0.43 10.9 0.1 3.3 2 1 0 2 2 2 1 AAA domain L31 PF09784.9 ETS59649.1 - 1e-41 141.4 0.2 1.2e-41 141.3 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 E1-E2_ATPase PF00122.20 ETS59650.1 - 5.9e-52 175.8 3.1 3e-51 173.5 0.3 2.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETS59650.1 - 1.2e-44 152.2 3.6 1.9e-44 151.6 1.8 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETS59650.1 - 1.5e-23 84.2 1.4 2.1e-22 80.5 1.4 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ETS59650.1 - 1.6e-22 78.9 0.0 3.6e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ETS59650.1 - 2.2e-18 66.1 0.0 4.2e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETS59650.1 - 1.6e-08 34.6 1.2 7e-06 26.0 0.9 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETS59650.1 - 5.7e-07 30.1 0.0 1.3e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Podoplanin PF05808.11 ETS59652.1 - 0.31 11.2 3.6 0.41 10.7 3.6 1.2 1 0 0 1 1 1 0 Podoplanin S10_plectin PF03501.15 ETS59653.1 - 8.1e-41 138.0 0.1 9.6e-41 137.8 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 ETS59653.1 - 0.1 12.4 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TrmB PF01978.19 ETS59653.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.5 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Ribosomal_S30 PF04758.14 ETS59655.1 - 1.6e-24 85.8 10.6 6e-23 80.8 7.7 2.1 2 0 0 2 2 2 2 Ribosomal protein S30 Snf7 PF03357.21 ETS59656.1 - 2.3e-21 76.2 9.1 3.5e-21 75.5 9.1 1.3 1 0 0 1 1 1 1 Snf7 V_ATPase_I PF01496.19 ETS59656.1 - 0.53 8.1 5.9 0.73 7.7 5.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF948 PF06103.11 ETS59656.1 - 3.5 7.9 4.7 2.1 8.7 0.6 2.3 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HA2 PF04408.23 ETS59657.1 - 5.6e-19 68.4 0.1 1.6e-18 66.9 0.1 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETS59657.1 - 4.5e-13 49.5 0.0 1.7e-12 47.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ETS59657.1 - 8.4e-12 45.3 0.0 2.7e-11 43.7 0.0 1.9 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ETS59657.1 - 1.8e-07 31.1 0.0 3.2e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETS59657.1 - 4.4e-05 23.8 0.0 0.00011 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS59657.1 - 0.00042 20.1 0.1 0.00075 19.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ETS59657.1 - 0.0057 15.8 0.0 0.017 14.2 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.6 ETS59657.1 - 0.0058 17.0 0.0 0.011 16.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 ETS59657.1 - 0.045 13.4 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATP_bind_2 PF03668.15 ETS59657.1 - 0.095 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 P-loop ATPase protein family FtsK_SpoIIIE PF01580.18 ETS59657.1 - 0.11 11.9 0.0 1 8.7 0.0 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.27 ETS59657.1 - 0.12 12.9 0.0 0.73 10.3 0.0 2.1 2 0 0 2 2 2 0 ABC transporter DUF2075 PF09848.9 ETS59657.1 - 0.2 10.8 0.0 0.3 10.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Peptidase_C2 PF00648.21 ETS59658.1 - 2.1e-20 72.9 0.0 5.8e-20 71.5 0.0 1.7 2 0 0 2 2 2 1 Calpain family cysteine protease Calpain_III PF01067.22 ETS59658.1 - 2.7e-14 53.6 0.0 0.0041 17.4 0.0 4.9 4 1 1 5 5 5 3 Calpain large subunit, domain III MIT PF04212.18 ETS59658.1 - 8.9e-10 38.5 0.2 1.4e-09 37.8 0.2 1.4 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain Pkinase PF00069.25 ETS59659.1 - 2.9e-51 174.4 0.0 4.1e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59659.1 - 2.4e-24 86.0 0.0 7.4e-23 81.1 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 ETS59659.1 - 0.012 14.6 0.0 0.018 14.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DASH_Spc19 PF08287.11 ETS59659.1 - 1.6 8.6 6.1 11 5.9 6.1 2.2 1 1 0 1 1 1 0 Spc19 SURF6 PF04935.12 ETS59659.1 - 1.7 8.4 8.4 3.3 7.4 8.4 1.5 1 0 0 1 1 1 0 Surfeit locus protein 6 APH PF01636.23 ETS59659.1 - 3.1 7.6 7.4 0.67 9.8 0.5 3.0 2 1 2 4 4 4 0 Phosphotransferase enzyme family DUF4720 PF15846.5 ETS59660.1 - 0.011 15.5 0.1 0.055 13.3 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4720) Pet100 PF09803.9 ETS59661.1 - 3.8e-28 97.8 0.2 5.5e-28 97.3 0.2 1.2 1 0 0 1 1 1 1 Pet100 LMWPc PF01451.21 ETS59662.1 - 3.3e-32 111.8 0.0 3.8e-32 111.6 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase adh_short PF00106.25 ETS59663.1 - 1.7e-12 47.2 0.7 4.8e-11 42.5 0.8 2.6 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS59663.1 - 1.3e-09 38.0 1.6 2.5e-08 33.8 1.6 2.2 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 ETS59663.1 - 0.00038 20.4 0.6 0.00062 19.7 0.6 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain KR PF08659.10 ETS59663.1 - 0.035 14.0 1.0 0.091 12.7 0.7 1.8 2 0 0 2 2 2 0 KR domain ApbA PF02558.16 ETS59663.1 - 0.11 12.2 0.2 0.21 11.2 0.2 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RBR PF17208.3 ETS59664.1 - 0.012 16.3 5.9 0.012 16.3 5.9 5.8 5 1 2 7 7 7 0 RNA binding Region DnaJ_C PF01556.18 ETS59665.1 - 3.1e-33 114.9 0.0 4.5e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ETS59665.1 - 8.5e-23 80.3 3.1 1.4e-22 79.6 3.1 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ETS59665.1 - 7.7e-10 39.0 18.3 7.7e-10 39.0 18.3 2.2 3 0 0 3 3 3 1 DnaJ central domain RNA_pol_Rpc4 PF05132.14 ETS59665.1 - 0.11 12.9 3.2 0.26 11.7 3.2 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 Use1 PF09753.9 ETS59665.1 - 1.9 8.2 4.0 3.1 7.4 4.0 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 zf-RRN7 PF11781.8 ETS59665.1 - 1.9 8.2 6.1 7.3 6.4 0.1 3.1 2 1 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ATP-synt_F PF01990.17 ETS59666.1 - 1.6e-29 102.0 0.2 1.9e-29 101.8 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DUF257 PF03192.13 ETS59666.1 - 0.0092 15.8 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 Pyrococcus protein of unknown function, DUF257 MFS_1 PF07690.16 ETS59667.1 - 5.4e-47 160.4 45.9 4e-46 157.6 46.3 2.1 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETS59667.1 - 1.3e-16 60.2 15.7 1.3e-16 60.2 15.7 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF3098 PF11297.8 ETS59667.1 - 0.34 10.5 4.8 3.7 7.2 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3098) OATP PF03137.20 ETS59667.1 - 4.2 5.5 11.7 0.18 10.0 4.2 2.3 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family p450 PF00067.22 ETS59668.1 - 5e-66 223.3 0.0 6.2e-66 223.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Zn_clus PF00172.18 ETS59669.1 - 3.6e-07 30.2 10.0 7.1e-07 29.3 10.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cnn_1N PF07989.11 ETS59669.1 - 0.054 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 SHE3 PF17078.5 ETS59669.1 - 0.06 13.1 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DivIC PF04977.15 ETS59669.1 - 0.1 12.4 0.9 0.23 11.2 0.9 1.5 1 0 0 1 1 1 0 Septum formation initiator SlyX PF04102.12 ETS59669.1 - 2.8 8.6 5.9 2.6 8.7 1.6 2.7 2 0 0 2 2 2 0 SlyX ALAD PF00490.21 ETS59671.1 - 1.2e-124 415.6 0.0 1.5e-124 415.3 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase RNA_pol_3_Rpc31 PF11705.8 ETS59672.1 - 1.4e-22 81.1 8.5 2.3e-22 80.4 8.5 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Glyco_transf_28 PF03033.20 ETS59673.1 - 1.5e-24 86.6 0.0 4e-24 85.2 0.0 1.8 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 ETS59673.1 - 1.4e-16 60.4 0.0 1.1e-07 31.7 0.0 2.7 3 0 0 3 3 3 2 GRAM domain PH PF00169.29 ETS59673.1 - 7.6e-11 42.5 0.1 2.2e-10 41.0 0.1 1.9 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ETS59673.1 - 1.2e-07 32.0 0.0 5.1e-07 30.0 0.1 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain UDPGT PF00201.18 ETS59673.1 - 0.002 17.0 0.0 0.0038 16.1 0.0 1.4 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_3 PF14593.6 ETS59673.1 - 0.013 15.6 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 PH domain TPR_1 PF00515.28 ETS59674.1 - 7.1e-47 155.4 32.1 1.8e-08 33.9 0.6 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat STI1 PF17830.1 ETS59674.1 - 2e-36 123.7 14.8 5.8e-20 71.0 2.9 3.1 2 0 0 2 2 2 2 STI1 domain TPR_2 PF07719.17 ETS59674.1 - 6.5e-36 119.6 30.4 4.7e-06 26.3 0.1 9.7 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_8 PF13181.6 ETS59674.1 - 2.6e-20 70.9 24.4 0.0012 18.9 0.3 9.2 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETS59674.1 - 1.1e-18 66.6 22.1 4.4e-08 32.7 0.0 7.5 6 2 2 8 8 8 6 TPR repeat TPR_19 PF14559.6 ETS59674.1 - 2.5e-16 59.9 18.4 0.00012 22.5 0.0 7.6 5 2 1 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETS59674.1 - 5.3e-16 57.9 22.2 0.099 13.5 0.0 9.9 6 3 4 10 10 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETS59674.1 - 1.2e-15 57.8 25.9 1.1e-06 29.2 0.2 6.8 5 2 1 7 7 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETS59674.1 - 9.2e-15 54.7 27.8 3.2e-10 40.2 0.3 8.0 6 3 2 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS59674.1 - 1.1e-10 41.1 1.6 0.32 11.5 0.0 6.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETS59674.1 - 2.8e-10 39.7 17.0 0.0075 16.1 0.0 8.8 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETS59674.1 - 1.1e-08 34.5 20.2 0.016 15.2 0.1 8.9 9 1 0 9 9 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS59674.1 - 6.4e-07 29.4 7.2 0.037 14.2 0.0 6.2 4 1 2 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETS59674.1 - 4.1e-05 23.9 16.8 1.4 9.7 0.0 8.0 9 0 0 9 9 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS59674.1 - 0.00034 20.8 13.9 0.0049 17.1 1.6 4.0 3 2 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 zf-C2H2_jaz PF12171.8 ETS59674.1 - 0.0051 17.1 0.8 0.07 13.4 0.2 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding NARP1 PF12569.8 ETS59674.1 - 0.011 14.7 0.4 0.011 14.7 0.4 5.1 4 2 0 5 5 3 0 NMDA receptor-regulated protein 1 XPC-binding PF09280.11 ETS59674.1 - 0.65 9.8 4.5 1.2 8.9 2.1 2.7 3 0 0 3 3 2 0 XPC-binding domain Tho2 PF11262.8 ETS59674.1 - 2.1 7.4 10.7 0.12 11.6 4.0 2.2 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 PAS_4 PF08448.10 ETS59674.1 - 7.2 6.9 9.4 2.7 8.3 0.1 3.6 4 0 0 4 4 3 0 PAS fold Suf PF05843.14 ETS59675.1 - 5.8e-89 299.0 2.7 6.7e-83 279.1 0.0 4.5 4 0 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 ETS59675.1 - 0.00076 20.1 29.6 0.055 14.3 0.0 8.8 9 1 1 10 10 10 3 Tetratricopeptide repeat HAT PF02184.16 ETS59675.1 - 0.04 13.9 3.2 4.4 7.3 0.0 4.3 4 0 0 4 4 4 0 HAT (Half-A-TPR) repeat NRDE-2 PF08424.10 ETS59675.1 - 0.26 10.4 5.9 0.2 10.8 0.2 3.3 3 1 0 3 3 3 0 NRDE-2, necessary for RNA interference DHHC PF01529.20 ETS59676.1 - 3.3e-10 40.2 0.3 9.8e-10 38.7 0.3 1.8 1 1 0 1 1 1 1 DHHC palmitoyltransferase STAG PF08514.11 ETS59677.1 - 6.3e-34 116.3 2.4 1.1e-33 115.5 0.8 2.4 2 0 0 2 2 2 1 STAG domain HEAT PF02985.22 ETS59677.1 - 0.0042 17.2 0.1 2 8.9 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat PAS PF00989.25 ETS59678.1 - 6.1e-11 42.3 0.0 7.8e-10 38.8 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 ETS59678.1 - 6e-09 36.1 0.0 9.8e-07 29.0 0.0 2.6 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 ETS59678.1 - 2e-08 34.4 0.0 1.4e-07 31.7 0.0 2.3 1 1 0 1 1 1 1 PAS fold PAS_9 PF13426.7 ETS59678.1 - 1.4e-07 31.7 0.0 2e-05 24.8 0.0 2.5 2 0 0 2 2 2 1 PAS domain PAS_11 PF14598.6 ETS59678.1 - 0.04 14.0 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 PAS domain PAS_8 PF13188.7 ETS59678.1 - 0.041 13.9 0.0 0.16 12.0 0.0 1.9 2 0 0 2 2 2 0 PAS domain PAS_2 PF08446.11 ETS59678.1 - 0.073 13.7 0.0 42 4.9 0.0 3.2 3 0 0 3 3 3 0 PAS fold Mfa1 PF17445.2 ETS59678.1 - 0.41 10.7 3.7 5.3 7.2 0.4 3.0 2 0 0 2 2 2 0 Mating factor A1 TauD PF02668.16 ETS59679.1 - 1.6e-39 136.3 0.0 2.4e-39 135.7 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ETS59679.1 - 8.1e-13 48.8 0.2 9.7e-12 45.4 0.0 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 ETS59679.1 - 0.012 14.8 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 CsiD SKA1 PF07160.12 ETS59681.1 - 3.1 7.6 5.7 3 7.6 4.2 1.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Proteasome PF00227.26 ETS59682.1 - 1.5e-57 194.2 0.3 2.8e-57 193.3 0.3 1.5 1 0 0 1 1 1 1 Proteasome subunit Ras PF00071.22 ETS59682.1 - 4.9e-45 153.0 0.0 7.5e-45 152.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS59682.1 - 2.4e-15 56.8 0.1 1.6e-14 54.1 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Proteasome_A_N PF10584.9 ETS59682.1 - 8.2e-14 51.0 0.2 1.7e-13 50.0 0.2 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Arf PF00025.21 ETS59682.1 - 4.3e-06 26.3 0.0 7.3e-06 25.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETS59682.1 - 0.0026 17.7 0.1 0.58 10.0 0.1 2.5 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ETS59682.1 - 0.0045 17.1 0.1 0.013 15.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ribonuc_L-PSP PF01042.21 ETS59683.1 - 0.087 12.8 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Endoribonuclease L-PSP tRNA-synt_1g PF09334.11 ETS59684.1 - 5.1e-91 305.3 1.1 1.9e-79 267.2 0.0 3.0 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ETS59684.1 - 8.7e-15 54.0 0.0 2.2e-07 29.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ETS59684.1 - 2.2e-07 30.6 0.3 0.016 14.6 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 ETS59684.1 - 0.00011 22.2 0.0 0.00031 20.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Asp PF00026.23 ETS59685.1 - 2.5e-71 240.7 6.6 3.9e-71 240.1 6.6 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS59685.1 - 2.8e-11 44.0 2.8 2.8e-11 44.0 2.8 3.5 2 1 1 3 3 3 1 Xylanase inhibitor N-terminal PPR_2 PF13041.6 ETS59686.1 - 9e-07 29.0 0.0 4.3e-06 26.8 0.0 2.2 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ETS59686.1 - 0.01 16.0 0.0 0.069 13.4 0.0 2.6 1 0 0 1 1 1 0 PPR repeat PPR_3 PF13812.6 ETS59686.1 - 0.23 11.6 0.0 1.9 8.6 0.0 2.4 3 1 1 4 4 4 0 Pentatricopeptide repeat domain UPF0261 PF06792.11 ETS59687.1 - 2.7e-147 490.9 0.0 3.1e-147 490.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) PEP_hydrolase PF09370.10 ETS59688.1 - 2.2e-128 427.1 0.3 2.5e-128 426.9 0.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like SPOR PF05036.13 ETS59688.1 - 0.11 12.8 0.0 11 6.5 0.0 2.5 2 0 0 2 2 2 0 Sporulation related domain zf-C2H2 PF00096.26 ETS59689.1 - 2.7e-07 30.7 10.3 0.0011 19.3 1.8 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETS59689.1 - 0.0005 20.4 4.0 0.0021 18.4 4.0 2.2 1 0 0 1 1 1 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETS59689.1 - 0.0023 18.6 9.7 0.16 12.9 1.6 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger Sugar_tr PF00083.24 ETS59691.1 - 1.3e-117 393.5 20.2 1.5e-117 393.2 20.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter zf-Tim10_DDP PF02953.15 ETS59691.1 - 8.6e-17 60.5 0.5 1.7e-16 59.6 0.5 1.5 1 0 0 1 1 1 1 Tim10/DDP family zinc finger MFS_1 PF07690.16 ETS59691.1 - 8.2e-16 57.9 41.7 2.2e-15 56.4 35.6 3.0 2 1 1 3 3 3 2 Major Facilitator Superfamily DUF2530 PF10745.9 ETS59691.1 - 1.8 8.8 10.4 0.1 12.8 3.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) DUF1100 PF06500.11 ETS59692.1 - 3.4e-09 36.0 0.0 5.5e-09 35.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_1 PF00561.20 ETS59692.1 - 7.4e-07 29.1 0.1 0.015 15.0 0.2 2.5 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS59692.1 - 3.9e-06 26.3 0.1 0.0039 16.5 0.1 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ETS59692.1 - 0.0043 16.7 0.0 0.0058 16.3 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) MIT PF04212.18 ETS59692.1 - 0.17 12.0 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain MA3 PF02847.17 ETS59693.1 - 4.5e-29 100.7 0.1 8.4e-29 99.8 0.1 1.5 1 0 0 1 1 1 1 MA3 domain COX6B PF02297.17 ETS59693.1 - 8.7e-24 83.6 0.7 2e-23 82.4 0.7 1.6 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb MIF4G PF02854.19 ETS59693.1 - 6.1e-14 52.2 0.8 6.3e-13 48.8 0.0 2.3 2 0 0 2 2 2 1 MIF4G domain Cnd1 PF12717.7 ETS59693.1 - 0.023 14.7 0.1 0.066 13.3 0.1 1.7 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Sigma70_ner PF04546.13 ETS59693.1 - 0.12 12.2 5.9 1.9 8.3 0.3 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region CTP_transf_like PF01467.26 ETS59694.1 - 1.7e-26 93.2 0.0 2.5e-26 92.6 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like Pox_MCEL PF03291.16 ETS59695.1 - 6.6e-76 255.6 0.0 1e-75 254.9 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 ETS59695.1 - 1.1e-09 38.9 0.0 2.2e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS59695.1 - 2e-07 30.9 0.0 3.6e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS59695.1 - 6.2e-07 30.0 0.0 1.2e-06 29.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS59695.1 - 4.1e-06 27.5 0.0 9.2e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS59695.1 - 2e-05 24.5 0.0 4.6e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ETS59695.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family tRNA-synt_1 PF00133.22 ETS59696.1 - 7.5e-152 506.7 0.0 1.1e-151 506.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ETS59696.1 - 2.9e-20 72.8 0.0 5.4e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ETS59696.1 - 5.3e-20 71.5 0.0 4e-12 45.6 0.0 3.3 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ETS59696.1 - 0.0026 17.3 0.0 0.005 16.4 0.0 1.4 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Fungal_trans PF04082.18 ETS59698.1 - 1.5e-06 27.5 1.0 2.6e-06 26.7 1.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS59698.1 - 6.9e-06 26.1 7.5 1.2e-05 25.3 7.5 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2306 PF10067.9 ETS59699.1 - 0.023 14.9 2.1 0.038 14.2 2.2 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2306) AMP-binding PF00501.28 ETS59700.1 - 4.9e-197 654.7 0.1 1.4e-68 231.4 0.0 3.2 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 ETS59700.1 - 5.9e-140 467.0 0.0 2.3e-43 148.5 0.0 5.5 5 0 0 5 5 5 5 Condensation domain PP-binding PF00550.25 ETS59700.1 - 3.7e-38 129.7 5.8 6.2e-09 36.1 0.1 6.0 5 0 0 5 5 5 5 Phosphopantetheine attachment site AMP-binding_C PF13193.6 ETS59700.1 - 2.2e-11 44.6 0.4 0.00073 20.5 0.0 4.4 4 0 0 4 4 4 2 AMP-binding enzyme C-terminal domain AATase PF07247.12 ETS59700.1 - 0.17 10.4 0.1 25 3.2 0.0 3.6 4 0 0 4 4 4 0 Alcohol acetyltransferase ECH_1 PF00378.20 ETS59701.1 - 1e-50 172.4 0.0 1.2e-50 172.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS59701.1 - 2.2e-26 93.2 0.0 4e-26 92.3 0.0 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Acetyltransf_8 PF13523.6 ETS59702.1 - 6.3e-28 97.3 0.7 1.1e-27 96.5 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain ABC_membrane PF00664.23 ETS59703.1 - 1.7e-64 218.1 23.2 3.9e-36 125.1 9.4 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS59703.1 - 3.8e-50 170.0 0.2 4.2e-28 98.6 0.1 2.9 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ETS59703.1 - 7.9e-10 38.5 1.3 1.8e-05 24.3 0.0 3.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ETS59703.1 - 6.2e-09 36.0 0.0 0.0024 17.8 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ETS59703.1 - 5.5e-08 33.4 4.4 0.0097 16.3 0.3 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_7 PF12775.7 ETS59703.1 - 5.5e-06 26.0 2.0 0.034 13.7 0.1 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ETS59703.1 - 5.6e-06 26.4 0.3 0.14 12.3 0.1 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 ETS59703.1 - 9.8e-06 25.2 0.5 0.096 12.4 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain IstB_IS21 PF01695.17 ETS59703.1 - 3.4e-05 23.6 2.6 0.54 10.0 0.1 3.8 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA PF00004.29 ETS59703.1 - 5.4e-05 23.6 0.2 0.11 12.9 0.1 3.2 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ETS59703.1 - 8.6e-05 21.7 1.5 0.087 11.9 0.0 2.8 4 0 0 4 4 3 2 Type II/IV secretion system protein AAA_30 PF13604.6 ETS59703.1 - 9.5e-05 22.2 2.5 0.011 15.4 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETS59703.1 - 0.0001 22.6 1.6 0.028 14.7 0.3 2.9 2 1 0 2 2 2 1 AAA domain MeaB PF03308.16 ETS59703.1 - 0.00024 20.2 2.3 0.038 13.0 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 ETS59703.1 - 0.00051 19.7 5.5 0.45 10.1 0.0 3.7 4 0 0 4 4 4 2 AAA domain Zeta_toxin PF06414.12 ETS59703.1 - 0.00087 18.6 1.3 0.57 9.4 0.2 2.7 2 0 0 2 2 2 2 Zeta toxin TsaE PF02367.17 ETS59703.1 - 0.0041 17.1 2.1 0.67 10.0 0.1 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETS59703.1 - 0.0047 17.3 0.7 1.4 9.3 0.0 3.3 4 0 0 4 4 2 1 RNA helicase ATP_bind_1 PF03029.17 ETS59703.1 - 0.0055 16.5 5.1 2.3 7.9 0.6 3.3 3 0 0 3 3 3 2 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 ETS59703.1 - 0.0058 16.8 3.8 0.4 10.8 1.4 3.3 3 1 0 3 3 2 1 AAA domain DUF87 PF01935.17 ETS59703.1 - 0.0064 16.6 5.2 0.19 11.8 0.4 2.6 2 0 0 2 2 2 1 Helicase HerA, central domain DUF815 PF05673.13 ETS59703.1 - 0.013 14.6 0.6 2.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Roc PF08477.13 ETS59703.1 - 0.014 15.6 1.5 8.6 6.6 0.1 3.1 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 ETS59703.1 - 0.031 14.2 0.5 0.51 10.2 0.0 2.7 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ETS59703.1 - 0.039 13.9 1.1 4 7.3 0.0 2.7 2 0 0 2 2 2 0 NACHT domain Dynamin_N PF00350.23 ETS59703.1 - 0.047 13.8 7.0 0.25 11.4 0.2 3.0 4 0 0 4 4 2 0 Dynamin family CbiA PF01656.23 ETS59703.1 - 0.058 13.5 0.0 3.9 7.6 0.0 3.1 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain FtsK_SpoIIIE PF01580.18 ETS59703.1 - 0.081 12.3 1.4 1.4 8.3 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_10 PF12846.7 ETS59703.1 - 0.13 11.1 0.1 3.3 6.5 0.1 2.3 2 0 0 2 2 2 0 AAA-like domain CLP1_P PF16575.5 ETS59703.1 - 0.22 11.3 1.2 19 5.0 0.1 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SbcCD_C PF13558.6 ETS59703.1 - 0.4 10.9 3.3 0.72 10.1 0.0 3.0 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit TrwB_AAD_bind PF10412.9 ETS59703.1 - 0.65 8.8 3.2 14 4.5 0.3 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain SRP54 PF00448.22 ETS59703.1 - 1.2 8.7 4.5 15 5.2 0.4 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 ETS59703.1 - 2.2 8.8 6.4 4.4 7.8 0.1 3.2 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 ETS59703.1 - 2.2 8.5 6.7 4.1 7.6 0.5 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ETS59703.1 - 4.1 7.0 7.4 17 5.0 0.4 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 ETS59703.1 - 4.9 7.1 8.2 2.5 8.0 0.3 3.4 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 ETS59703.1 - 5.4 6.9 7.1 1.5 8.7 0.2 3.0 3 0 0 3 3 3 0 NTPase DUF2075 PF09848.9 ETS59703.1 - 5.8 6.0 5.9 18 4.4 0.2 2.9 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MFS_1 PF07690.16 ETS59704.1 - 4e-20 72.0 37.5 7.6e-18 64.6 13.4 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETS59704.1 - 5e-08 31.9 0.7 5e-08 31.9 0.7 3.4 2 1 1 3 3 3 2 MFS/sugar transport protein Pox_A14 PF05767.12 ETS59704.1 - 0.031 14.4 0.4 0.031 14.4 0.4 2.8 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF5368 PF17336.2 ETS59704.1 - 0.47 10.7 6.1 0.1 12.8 1.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5368) Pyr_redox_2 PF07992.14 ETS59705.1 - 1.1e-28 100.4 0.0 1.4e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS59705.1 - 9.1e-10 39.0 0.0 3.1e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS59705.1 - 0.14 11.4 0.0 2 7.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Bac_rhamnosid_C PF17390.2 ETS59706.1 - 8.9e-09 35.0 0.1 1.6e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase C-terminal domain UNC45-central PF11701.8 ETS59707.1 - 4.7e-12 46.1 0.2 3.6e-11 43.3 0.2 2.4 1 1 0 1 1 1 1 Myosin-binding striated muscle assembly central RNA_pol_Rpb1_1 PF04997.12 ETS59708.1 - 2e-85 286.9 0.1 3e-85 286.3 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 ETS59708.1 - 1.9e-82 276.7 0.5 2.8e-82 276.2 0.5 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ETS59708.1 - 3.9e-72 241.9 0.0 6.9e-72 241.1 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 FAA_hydrolase PF01557.18 ETS59708.1 - 1.1e-52 178.9 0.0 1.8e-52 178.1 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family RNA_pol_Rpb1_3 PF04983.18 ETS59708.1 - 9e-37 126.4 0.0 4.4e-36 124.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ETS59708.1 - 9.6e-31 105.9 0.0 2.2e-30 104.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF2225 PF09986.9 ETS59708.1 - 0.063 13.0 0.5 0.12 12.1 0.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zinc_ribbon_15 PF17032.5 ETS59708.1 - 0.13 13.0 1.1 0.31 11.8 1.1 1.6 1 0 0 1 1 1 0 zinc-ribbon family zf-tcix PF14952.6 ETS59708.1 - 0.2 11.3 0.5 0.54 9.9 0.5 1.7 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding DUF4965 PF16335.5 ETS59709.1 - 2.7e-70 235.5 0.1 5.2e-70 234.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 ETS59709.1 - 7.3e-65 218.5 1.3 1.3e-64 217.6 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) DUF5127 PF17168.4 ETS59709.1 - 5.1e-50 170.4 3.9 5.1e-50 170.4 3.9 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5127) DUF4964 PF16334.5 ETS59709.1 - 0.039 13.5 1.1 6.1 6.5 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4964) URO-D PF01208.17 ETS59710.1 - 3.2e-138 460.6 0.0 3.6e-138 460.4 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) RTA1 PF04479.13 ETS59711.1 - 1e-52 178.8 7.8 1.6e-52 178.2 7.8 1.2 1 0 0 1 1 1 1 RTA1 like protein DUF308 PF03729.13 ETS59711.1 - 0.0055 17.0 1.1 0.0055 17.0 1.1 3.5 3 2 0 3 3 3 1 Short repeat of unknown function (DUF308) Histidinol_dh PF00815.20 ETS59711.1 - 0.12 11.4 0.1 0.16 11.0 0.1 1.1 1 0 0 1 1 1 0 Histidinol dehydrogenase Na_H_Exchanger PF00999.21 ETS59712.1 - 4.4e-17 61.9 42.1 9.6e-12 44.4 11.4 2.2 2 0 0 2 2 2 2 Sodium/hydrogen exchanger family DUF5531 PF17671.1 ETS59712.1 - 0.19 11.6 0.0 0.4 10.6 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5531) Pkinase PF00069.25 ETS59713.1 - 2.2e-70 237.0 0.0 3.2e-70 236.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Abhydrolase_3 PF07859.13 ETS59713.1 - 1.6e-47 162.1 0.0 3.9e-47 160.8 0.0 1.7 1 0 0 1 1 1 1 alpha/beta hydrolase fold Pkinase_Tyr PF07714.17 ETS59713.1 - 1.6e-34 119.4 0.0 2.3e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Say1_Mug180 PF10340.9 ETS59713.1 - 2.5e-12 46.3 0.0 7.3e-12 44.8 0.0 1.7 1 1 0 1 1 1 1 Steryl acetyl hydrolase YrbL-PhoP_reg PF10707.9 ETS59713.1 - 5.2e-05 22.9 0.0 0.0001 21.9 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Kdo PF06293.14 ETS59713.1 - 0.0083 15.5 0.5 0.017 14.5 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETS59713.1 - 0.037 13.3 0.0 0.55 9.5 0.0 2.3 2 0 0 2 2 2 0 Kinase-like CCDC106 PF15794.5 ETS59713.1 - 5.9 6.5 10.2 0.69 9.6 0.6 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 ArAE_2_N PF10337.9 ETS59714.1 - 2.3e-63 214.9 3.8 5.8e-63 213.6 0.3 2.6 2 0 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 ETS59714.1 - 1.1e-22 81.0 0.1 4.3e-11 43.1 0.0 3.5 3 0 0 3 3 3 3 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 ETS59714.1 - 4.6e-09 36.5 20.7 4.6e-09 36.5 20.7 4.0 2 2 3 5 5 5 1 Fusaric acid resistance protein-like ALMT PF11744.8 ETS59714.1 - 0.16 10.8 0.0 0.16 10.8 0.0 1.8 2 0 0 2 2 2 0 Aluminium activated malate transporter HMG_box PF00505.19 ETS59715.1 - 3.6e-15 56.1 2.2 7e-15 55.2 2.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS59715.1 - 2e-11 44.3 1.3 3.6e-11 43.5 1.3 1.4 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 ETS59715.1 - 0.00081 19.3 0.1 0.0032 17.4 0.0 1.9 2 0 0 2 2 2 1 CHDNT (NUC034) domain PhageMin_Tail PF10145.9 ETS59715.1 - 0.012 15.5 0.3 0.024 14.5 0.3 1.5 1 1 0 1 1 1 0 Phage-related minor tail protein DinB PF05163.12 ETS59716.1 - 0.029 14.3 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 DinB family DinB_2 PF12867.7 ETS59716.1 - 0.03 14.8 0.0 0.049 14.1 0.0 1.4 1 0 0 1 1 1 0 DinB superfamily Translin PF01997.16 ETS59717.1 - 4.3e-56 190.2 0.0 5.1e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Translin family SSXT PF05030.12 ETS59719.1 - 0.0077 15.8 0.0 0.021 14.4 0.0 1.7 1 0 0 1 1 1 1 SSXT protein (N-terminal region) Vfa1 PF08432.10 ETS59720.1 - 2.2e-37 129.1 3.1 3.1e-37 128.7 3.1 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 LIAS_N PF16881.5 ETS59720.1 - 0.035 14.5 2.6 0.084 13.3 0.3 2.2 2 1 0 2 2 2 0 N-terminal domain of lipoyl synthase of Radical_SAM family DUF719 PF05334.13 ETS59720.1 - 0.085 13.1 2.9 0.13 12.4 2.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF719) Peptidase_S64 PF08192.11 ETS59720.1 - 1 7.7 5.2 1.2 7.6 5.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 PIN_5 PF08745.11 ETS59722.1 - 0.13 11.6 0.1 0.25 10.7 0.1 1.3 1 0 0 1 1 1 0 PINc domain ribonuclease PMI_typeI PF01238.21 ETS59724.1 - 1.7e-110 369.8 0.0 2e-110 369.5 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Cupin_2 PF07883.11 ETS59724.1 - 6.2e-06 25.8 0.0 0.0021 17.8 0.1 2.4 2 0 0 2 2 2 2 Cupin domain DUF2834 PF11196.8 ETS59725.1 - 1.2e-08 35.2 14.4 0.00099 19.4 2.1 4.4 4 0 0 4 4 4 4 Protein of unknown function (DUF2834) UPF0542 PF15086.6 ETS59725.1 - 0.15 12.0 0.1 8.1 6.5 0.0 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 CGI-121 PF08617.10 ETS59726.1 - 8.9e-49 165.7 0.0 1.1e-48 165.5 0.0 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Alpha_Helical PF18489.1 ETS59726.1 - 0.061 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Alpha helical domain NDUF_B7 PF05676.13 ETS59727.1 - 3e-18 65.3 0.2 4.6e-18 64.7 0.2 1.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 ETS59727.1 - 0.017 15.1 0.0 0.031 14.3 0.0 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like S36_mt PF10937.8 ETS59728.1 - 3.7e-05 25.3 4.1 7.5e-05 24.3 4.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S36, mitochondrial DUF4211 PF13926.6 ETS59729.1 - 1.6e-10 41.2 0.1 7.4e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4211) SNARE PF05739.19 ETS59730.1 - 9.2e-12 44.8 0.4 9.2e-12 44.8 0.4 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ETS59730.1 - 9.1e-06 25.5 2.3 9.1e-06 25.5 2.3 2.4 3 0 0 3 3 3 2 Syntaxin MCPsignal PF00015.21 ETS59730.1 - 0.062 13.1 2.2 0.14 12.0 0.2 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlaC_arch PF05377.11 ETS59730.1 - 0.56 10.6 2.8 0.51 10.8 0.2 2.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 ETS59730.1 - 0.72 10.2 4.3 1.9 8.8 1.1 2.7 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4200 PF13863.6 ETS59730.1 - 3.2 8.2 7.9 0.29 11.5 2.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) PMT PF02366.18 ETS59731.1 - 4.8e-78 262.1 12.2 4.8e-78 262.1 12.2 2.1 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ETS59731.1 - 1.9e-66 223.4 5.4 1.9e-66 223.4 5.4 2.3 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ETS59731.1 - 1.3e-40 139.2 0.3 3e-40 138.1 0.3 1.6 1 1 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ETS59731.1 - 0.0003 21.1 10.3 0.0003 21.1 10.3 3.0 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Abhydro_lipase PF04083.16 ETS59732.1 - 2.7e-16 58.9 0.0 5.8e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ETS59732.1 - 4e-09 36.5 0.1 9.5e-09 35.3 0.1 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS59732.1 - 0.025 13.8 0.1 0.065 12.5 0.1 1.6 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Sec63 PF02889.16 ETS59733.1 - 5.6e-16 58.5 0.0 1.5e-10 40.7 0.0 2.1 2 0 0 2 2 2 2 Sec63 Brl domain DnaJ PF00226.31 ETS59733.1 - 1.9e-15 56.7 1.2 4.5e-15 55.5 1.2 1.7 1 0 0 1 1 1 1 DnaJ domain DDOST_48kD PF03345.14 ETS59733.1 - 0.028 13.3 0.1 5.3 5.8 0.0 2.3 2 0 0 2 2 2 0 Oligosaccharyltransferase 48 kDa subunit beta PITH PF06201.13 ETS59734.1 - 7.9e-30 104.1 0.0 1.5e-29 103.2 0.0 1.5 1 0 0 1 1 1 1 PITH domain CENP-T_C PF15511.6 ETS59734.1 - 3.6e-09 36.7 2.5 4.9e-09 36.3 0.5 2.1 1 1 1 2 2 2 1 Centromere kinetochore component CENP-T histone fold MAM33 PF02330.16 ETS59735.1 - 4.1e-66 223.0 0.1 4.8e-66 222.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein RRM_1 PF00076.22 ETS59736.1 - 2.5e-15 56.1 0.0 6.8e-06 25.8 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AF-4 PF05110.13 ETS59736.1 - 4.7 5.2 43.0 0.0046 15.1 23.9 3.0 3 0 0 3 3 3 0 AF-4 proto-oncoprotein tRNA-synt_2b PF00587.25 ETS59737.1 - 1.1e-29 103.7 0.0 2.2e-29 102.7 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ETS59737.1 - 0.00098 19.2 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain Acyl-CoA_dh_1 PF00441.24 ETS59738.1 - 3e-44 150.8 3.8 3e-44 150.8 3.8 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETS59738.1 - 1e-26 93.8 1.0 4.5e-26 91.7 0.0 2.5 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETS59738.1 - 1.8e-22 79.3 0.1 3.6e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETS59738.1 - 6.9e-22 78.2 1.1 6.9e-22 78.2 1.1 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Snf7 PF03357.21 ETS59738.1 - 0.0029 17.2 1.4 0.0061 16.2 1.4 1.4 1 0 0 1 1 1 1 Snf7 Prefoldin_2 PF01920.20 ETS59738.1 - 0.057 13.4 0.2 3.6 7.6 0.1 2.4 2 0 0 2 2 2 0 Prefoldin subunit adh_short_C2 PF13561.6 ETS59739.1 - 1.4e-46 158.9 0.1 2.9e-46 157.9 0.1 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS59739.1 - 2.1e-36 125.2 0.0 4.1e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase DSPn PF14671.6 ETS59739.1 - 3.6e-36 124.7 0.0 3.9e-35 121.4 0.0 2.2 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 ETS59739.1 - 7.2e-12 45.3 0.0 1.4e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain KR PF08659.10 ETS59739.1 - 1.1e-08 35.2 0.0 2.9e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 KR domain Y_phosphatase PF00102.27 ETS59739.1 - 0.00072 19.2 0.0 0.0016 18.0 0.0 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Urate_ox_N PF06181.11 ETS59739.1 - 0.036 13.4 0.5 0.062 12.6 0.5 1.3 1 0 0 1 1 1 0 Urate oxidase N-terminal PTPlike_phytase PF14566.6 ETS59739.1 - 0.12 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate ThiF PF00899.21 ETS59740.1 - 1.5e-98 329.1 0.0 5.5e-68 228.9 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ETS59740.1 - 1.9e-89 299.9 0.0 2.9e-89 299.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 ETS59740.1 - 2.3e-32 111.0 0.4 5.2e-32 109.9 0.4 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 ETS59740.1 - 3e-31 108.0 0.1 5.7e-31 107.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 ETS59740.1 - 3.2e-26 91.3 0.5 7.5e-26 90.1 0.5 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Glyco_hydro_18 PF00704.28 ETS59743.1 - 2.7e-59 201.5 0.2 3.3e-59 201.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 2-Hacid_dh_C PF02826.19 ETS59744.1 - 1.1e-26 93.3 0.2 1.6e-25 89.5 0.2 2.1 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 ETS59744.1 - 0.00042 19.7 0.3 0.00091 18.6 0.2 1.6 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 ETS59744.1 - 0.0093 16.4 0.3 0.041 14.3 0.2 1.9 1 1 0 1 1 1 1 Putative NAD(P)-binding XdhC_C PF13478.6 ETS59744.1 - 0.019 15.4 0.1 0.034 14.7 0.1 1.6 1 1 0 1 1 1 0 XdhC Rossmann domain Shikimate_DH PF01488.20 ETS59744.1 - 0.029 14.4 0.1 0.078 13.0 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Gln-synt_N_2 PF16952.5 ETS59744.1 - 0.039 13.8 0.1 0.076 12.9 0.1 1.5 1 0 0 1 1 1 0 Glutamine synthetase N-terminal domain F420_oxidored PF03807.17 ETS59744.1 - 0.1 13.2 0.1 1.6 9.4 0.1 2.4 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 ETS59744.1 - 0.21 10.9 2.8 4.7 6.4 0.2 2.8 1 1 2 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain RRM_1 PF00076.22 ETS59745.1 - 3e-39 132.7 0.0 8.5e-21 73.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETS59745.1 - 4.8e-07 29.8 0.0 0.00032 20.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 ETS59745.1 - 0.017 15.2 5.7 0.26 11.4 0.0 2.9 2 1 1 3 3 3 0 RNA binding motif RRM_5 PF13893.6 ETS59745.1 - 0.02 14.5 0.0 0.093 12.3 0.0 2.0 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.9 ETS59745.1 - 0.83 8.1 30.7 1.3 7.4 30.7 1.3 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 ETS59745.1 - 2.2 7.8 73.4 5.1 6.6 26.6 3.0 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein NUDIX PF00293.28 ETS59746.1 - 6.4e-15 55.4 0.0 1.3e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 ETS59746.1 - 7.7e-12 45.8 0.1 1.9e-11 44.5 0.1 1.7 1 0 0 1 1 1 1 NADH pyrophosphatase-like rudimentary NUDIX domain 7TM_GPCR_Str PF10326.9 ETS59746.1 - 0.19 11.1 0.0 2.2 7.5 0.0 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Str EMG1 PF03587.14 ETS59747.1 - 6.3e-78 260.9 0.0 1.5e-77 259.6 0.0 1.6 2 0 0 2 2 2 1 EMG1/NEP1 methyltransferase DUF3498 PF12004.8 ETS59747.1 - 0.064 12.4 0.0 0.064 12.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3498) Ank_4 PF13637.6 ETS59748.1 - 5.1e-19 68.4 1.9 7.4e-11 42.4 0.2 4.7 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS59748.1 - 4.3e-18 65.7 0.0 2e-08 34.7 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETS59748.1 - 4e-14 52.3 0.0 4.5e-05 23.7 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETS59748.1 - 2.7e-12 46.7 1.0 3.4e-06 27.2 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETS59748.1 - 2.7e-12 45.7 0.2 0.00078 19.7 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 ETS59748.1 - 2.6e-06 27.2 0.1 3.3e-05 23.7 0.1 2.3 1 1 0 1 1 1 1 KilA-N domain UPF0300 PF08594.10 ETS59748.1 - 0.072 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0300) MRP-S34 PF16053.5 ETS59749.1 - 9.7e-10 38.2 0.3 7.2e-06 25.7 0.1 2.2 1 1 1 2 2 2 2 Mitochondrial 28S ribosomal protein S34 MoCF_biosynth PF00994.24 ETS59751.1 - 3.5e-57 192.1 0.7 3e-30 104.8 0.1 2.4 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 ETS59751.1 - 8.3e-33 113.4 1.2 1.3e-32 112.7 1.2 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 ETS59751.1 - 1.3e-10 41.3 1.7 4.4e-10 39.6 0.2 2.9 3 0 0 3 3 3 1 MoeA C-terminal region (domain IV) SH3_9 PF14604.6 ETS59752.1 - 2.7e-08 33.5 0.0 4.6e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ETS59752.1 - 6.4e-07 28.9 0.0 1.1e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETS59752.1 - 0.00072 19.2 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain ribosomal_L24 PF17136.4 ETS59753.1 - 0.023 15.1 0.0 0.056 13.9 0.0 1.7 1 0 0 1 1 1 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 ETS59753.1 - 0.16 12.0 1.9 18 5.5 0.0 3.2 3 0 0 3 3 3 0 KOW motif DUF2502 PF10697.9 ETS59753.1 - 0.19 12.1 4.8 0.17 12.3 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2502) ACBP PF00887.19 ETS59754.1 - 3.9e-24 84.7 0.0 7.7e-24 83.7 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein Peroxin-3 PF04882.12 ETS59755.1 - 5.6e-144 480.7 0.4 2.2e-143 478.7 0.4 1.7 1 1 0 1 1 1 1 Peroxin-3 PAM2 PF07145.15 ETS59755.1 - 0.011 15.3 0.2 0.036 13.7 0.2 2.0 1 0 0 1 1 1 0 Ataxin-2 C-terminal region TIP49 PF06068.13 ETS59756.1 - 3.8e-171 569.0 0.6 3.5e-143 477.0 0.2 2.5 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 ETS59756.1 - 7.7e-21 74.0 0.1 1.9e-20 72.8 0.1 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 ETS59756.1 - 1e-09 38.9 0.9 2.2e-06 28.1 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETS59756.1 - 1.6e-08 34.5 0.2 1.7e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETS59756.1 - 6.6e-06 26.4 0.1 0.058 13.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ETS59756.1 - 0.00032 20.7 0.1 0.12 12.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETS59756.1 - 0.00038 20.9 0.0 0.0036 17.7 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_19 PF13245.6 ETS59756.1 - 0.00092 19.6 3.2 0.046 14.1 3.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETS59756.1 - 0.0034 17.6 0.1 0.008 16.4 0.1 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 ETS59756.1 - 0.0049 16.6 0.1 2.6 7.7 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 ETS59756.1 - 0.0094 15.5 0.1 0.037 13.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETS59756.1 - 0.0097 15.3 0.1 0.57 9.5 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 ETS59756.1 - 0.012 14.9 0.4 0.026 13.8 0.4 1.5 1 0 0 1 1 1 0 Zeta toxin DnaB_C PF03796.15 ETS59756.1 - 0.039 13.3 0.0 0.073 12.4 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 ETS59756.1 - 0.054 13.2 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein UBA_2 PF08587.11 ETS59756.1 - 0.056 13.6 0.1 0.17 12.0 0.1 1.8 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DUF2075 PF09848.9 ETS59756.1 - 0.11 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ALG3 PF05208.13 ETS59757.1 - 3.2e-127 424.9 15.1 4.2e-127 424.5 13.5 2.0 2 0 0 2 2 2 1 ALG3 protein Gaa1 PF04114.14 ETS59757.1 - 4.9e-81 273.2 3.4 1.6e-80 271.5 0.0 2.5 2 1 0 2 2 2 1 Gaa1-like, GPI transamidase component Peptidase_M28 PF04389.17 ETS59757.1 - 0.11 12.1 0.2 0.46 10.2 0.1 2.0 1 1 1 2 2 2 0 Peptidase family M28 Ecm33 PF12454.8 ETS59757.1 - 2.7 8.2 6.1 0.9 9.7 0.8 2.7 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein TAF4 PF05236.14 ETS59758.1 - 2.4e-37 129.2 3.5 5.2e-37 128.1 3.5 1.6 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family DUF4235 PF14019.6 ETS59758.1 - 3.1 8.0 8.0 0.26 11.4 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4235) DUF3546 PF12066.8 ETS59759.1 - 3.6e-16 59.3 3.1 5.5e-15 55.5 1.5 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) ARS2 PF04959.13 ETS59759.1 - 7.8e-13 49.2 0.0 1.8e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Arsenite-resistance protein 2 MIF4G_like PF09088.11 ETS59760.1 - 1.3e-75 253.4 0.0 2.9e-75 252.3 0.0 1.6 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 ETS59760.1 - 2e-67 227.5 0.0 3.6e-67 226.7 0.0 1.4 1 0 0 1 1 1 1 MIF4G like Erythrovirus_X PF06795.11 ETS59760.1 - 0.032 14.5 0.1 0.072 13.4 0.1 1.6 1 0 0 1 1 1 0 Erythrovirus X protein Spt4 PF06093.13 ETS59761.1 - 1.4e-32 111.6 0.0 1.7e-32 111.4 0.0 1.0 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Cyclin_N PF00134.23 ETS59762.1 - 1.3e-13 50.8 0.6 3.1e-13 49.6 0.3 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 ETS59762.1 - 0.0026 17.8 0.5 0.006 16.6 0.5 1.7 1 0 0 1 1 1 1 Transcription factor TFIIB repeat Cyclin_C_2 PF16899.5 ETS59762.1 - 0.047 14.1 1.3 0.056 13.8 0.3 1.8 2 1 0 2 2 2 0 Cyclin C-terminal domain CPBP PF02517.16 ETS59763.1 - 3.8e-14 52.8 4.8 3.8e-14 52.8 4.8 1.8 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease PapJ PF14855.6 ETS59763.1 - 0.24 11.1 0.0 0.36 10.5 0.0 1.2 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone AAA PF00004.29 ETS59764.1 - 0.00078 19.9 0.0 0.003 18.0 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS59764.1 - 0.074 13.3 0.0 0.73 10.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETS59764.1 - 0.088 13.2 0.0 0.088 13.2 0.0 2.9 4 0 0 4 4 4 0 AAA ATPase domain Rad17 PF03215.15 ETS59764.1 - 0.22 11.4 0.0 0.96 9.3 0.0 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain RICTOR_N PF14664.6 ETS59766.1 - 7.7e-106 354.2 0.1 5.8e-105 351.3 0.1 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 ETS59766.1 - 8.8e-39 131.5 0.2 4.1e-35 119.7 0.0 4.3 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 ETS59766.1 - 1.1e-33 115.9 2.0 3e-33 114.5 0.1 2.7 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 ETS59766.1 - 7.4e-31 106.2 1.4 1.1e-28 99.2 0.1 4.2 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 ETS59766.1 - 5.7e-15 55.2 1.6 5.7e-15 55.2 1.6 2.4 2 0 0 2 2 2 1 Hr1 repeat HEAT PF02985.22 ETS59766.1 - 0.14 12.5 8.6 26 5.4 0.0 5.3 5 0 0 5 5 5 0 HEAT repeat HEAT_EZ PF13513.6 ETS59766.1 - 2.9 8.5 11.4 17 6.1 1.7 5.5 5 0 0 5 5 5 0 HEAT-like repeat Thioredoxin PF00085.20 ETS59767.1 - 1.7e-40 137.2 0.2 5e-22 77.8 0.0 4.0 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 ETS59767.1 - 1.6e-14 54.3 0.0 1.5e-08 34.8 0.0 3.6 3 1 0 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ETS59767.1 - 1.1e-08 35.5 0.0 0.00042 20.7 0.0 3.1 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ETS59767.1 - 0.00021 21.6 0.1 0.022 15.1 0.0 3.3 3 1 1 4 4 4 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ETS59767.1 - 0.00032 20.8 0.1 0.0078 16.4 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ETS59767.1 - 0.00055 19.9 0.0 0.27 11.3 0.0 2.7 2 0 0 2 2 2 1 Thioredoxin domain Redoxin PF08534.10 ETS59767.1 - 0.0017 18.0 0.8 2.7 7.7 0.1 2.8 2 1 0 2 2 2 2 Redoxin Thioredoxin_4 PF13462.6 ETS59767.1 - 0.0032 17.6 4.5 0.61 10.2 0.2 3.3 3 1 0 3 3 3 2 Thioredoxin AhpC-TSA PF00578.21 ETS59767.1 - 0.0079 16.1 0.0 0.033 14.1 0.0 2.0 2 0 0 2 2 2 1 AhpC/TSA family OST3_OST6 PF04756.13 ETS59767.1 - 0.023 14.1 0.2 16 4.7 0.0 3.4 3 1 0 3 3 3 0 OST3 / OST6 family, transporter family TraF PF13728.6 ETS59767.1 - 0.073 12.9 0.0 0.55 10.0 0.0 2.4 2 0 0 2 2 2 0 F plasmid transfer operon protein AbiJ_NTD5 PF18865.1 ETS59767.1 - 0.17 11.7 0.0 0.37 10.6 0.0 1.4 1 0 0 1 1 1 0 AbiJ N-terminal domain 5 Glutaredoxin PF00462.24 ETS59767.1 - 0.29 11.4 2.1 0.85 9.9 0.1 2.5 2 0 0 2 2 2 0 Glutaredoxin AF-4 PF05110.13 ETS59767.1 - 0.79 7.7 5.9 1.2 7.2 5.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 ETS59767.1 - 3.8 7.0 7.4 8.7 5.9 7.4 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein His_biosynth PF00977.21 ETS59768.1 - 6.2e-36 124.0 0.0 1e-35 123.3 0.0 1.3 1 0 0 1 1 1 1 Histidine biosynthesis protein GST_N PF02798.20 ETS59768.1 - 9.4e-13 48.3 0.0 1.8e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ETS59768.1 - 2.5e-06 27.8 0.1 4.5e-06 27.0 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETS59768.1 - 5.5e-05 23.4 0.1 0.00011 22.4 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETS59768.1 - 0.036 14.3 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Actin PF00022.19 ETS59769.1 - 3.8e-149 496.7 0.0 1.3e-148 495.0 0.0 1.7 1 1 0 1 1 1 1 Actin Vps8 PF12816.7 ETS59769.1 - 0.19 11.2 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 SLT PF01464.20 ETS59770.1 - 2e-16 59.7 0.0 2e-16 59.7 0.0 2.6 2 1 1 3 3 3 1 Transglycosylase SLT domain Macoilin PF09726.9 ETS59770.1 - 0.015 13.9 29.7 0.019 13.6 29.7 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 ETS59770.1 - 0.017 12.3 23.4 0.02 12.0 23.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 ETS59770.1 - 0.024 13.9 27.2 0.03 13.5 27.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Mem_trans PF03547.18 ETS59770.1 - 0.032 12.6 3.2 0.042 12.2 3.2 1.2 1 0 0 1 1 1 0 Membrane transport protein SPX PF03105.19 ETS59770.1 - 1.1 9.1 30.9 1.4 8.7 30.9 1.1 1 0 0 1 1 1 0 SPX domain Plasmodium_Vir PF05795.11 ETS59770.1 - 2.3 7.6 21.6 3.5 6.9 21.6 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RR_TM4-6 PF06459.12 ETS59770.1 - 9.5 6.0 16.9 14 5.4 16.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Utp14 PF04615.13 ETS59770.1 - 9.9 4.6 24.9 12 4.3 24.9 1.0 1 0 0 1 1 1 0 Utp14 protein Rad10 PF03834.14 ETS59771.1 - 1.5e-48 163.6 0.5 2.3e-48 163.0 0.5 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 ETS59771.1 - 1.4e-07 32.0 0.0 7.9e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Ribosomal_L2_C PF03947.18 ETS59772.1 - 2.6e-45 153.7 2.3 2.6e-45 153.7 2.3 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ETS59772.1 - 1.1e-07 31.7 0.4 0.0001 22.2 0.3 2.7 2 0 0 2 2 2 2 Ribosomal Proteins L2, RNA binding domain MCPVI PF02993.14 ETS59773.1 - 0.00021 21.2 2.0 0.00029 20.7 2.0 1.2 1 0 0 1 1 1 1 Minor capsid protein VI Goodbye PF17109.5 ETS59774.1 - 0.19 12.2 1.4 0.22 12.0 0.2 1.7 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain GTP_EFTU PF00009.27 ETS59776.1 - 1.2e-34 119.6 0.0 8.8e-34 116.7 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ETS59776.1 - 5.9e-17 61.7 0.2 2.7e-16 59.6 0.0 2.2 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 ETS59776.1 - 4.6e-13 49.4 8.8 8.4e-10 38.9 0.2 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETS59776.1 - 1.9e-06 28.0 0.2 8.2e-06 25.9 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 ETS59776.1 - 0.0002 21.5 0.0 0.00068 19.9 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU_D4 PF14578.6 ETS59776.1 - 0.0075 16.1 0.1 0.021 14.7 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Ras PF00071.22 ETS59776.1 - 0.11 12.1 0.2 0.44 10.1 0.0 2.1 2 1 0 2 2 2 0 Ras family Cgr1 PF03879.14 ETS59777.1 - 3.9e-20 72.2 22.6 4.3e-20 72.1 22.6 1.0 1 0 0 1 1 1 1 Cgr1 family Auts2 PF15336.6 ETS59777.1 - 0.32 11.1 6.8 0.38 10.8 6.8 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein SID-1_RNA_chan PF13965.6 ETS59777.1 - 5.3 5.3 4.4 5.8 5.2 4.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RR_TM4-6 PF06459.12 ETS59777.1 - 9.1 6.0 14.8 10 5.9 14.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2433 PF10360.9 ETS59778.1 - 3.8e-44 149.8 0.3 8.6e-44 148.6 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) RRM_1 PF00076.22 ETS59778.1 - 0.00031 20.5 0.1 0.069 13.0 0.1 2.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos PF00149.28 ETS59778.1 - 0.024 15.2 0.0 0.13 12.7 0.0 2.0 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETS59778.1 - 0.066 13.4 0.1 0.22 11.7 0.1 1.9 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Myb_DNA-binding PF00249.31 ETS59779.1 - 0.007 16.5 3.1 0.063 13.5 3.1 2.1 1 1 0 1 1 1 1 Myb-like DNA-binding domain DEAD PF00270.29 ETS59780.1 - 5.8e-40 136.9 0.0 1e-39 136.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS59780.1 - 1.8e-17 63.7 0.0 4.8e-17 62.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ETS59780.1 - 9.9e-16 57.7 0.5 2.5e-15 56.4 0.5 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ETS59780.1 - 3.2e-06 27.3 0.0 6.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SDA1 PF05285.12 ETS59781.1 - 2.8e-94 316.4 43.7 2.8e-94 316.4 43.7 2.1 2 0 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 ETS59781.1 - 1.6e-18 66.7 0.1 4.3e-18 65.4 0.1 1.8 1 0 0 1 1 1 1 NUC130/3NT domain DUF733 PF05306.11 ETS59781.1 - 1 9.7 11.8 1.1 9.6 4.5 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF733) VTC PF09359.10 ETS59782.1 - 2.5e-99 332.2 0.0 2.5e-99 332.2 0.0 2.0 3 0 0 3 3 3 1 VTC domain SPX PF03105.19 ETS59782.1 - 1.5e-17 64.7 32.9 8.5e-07 29.2 1.7 4.5 3 2 1 4 4 4 3 SPX domain DUF202 PF02656.15 ETS59782.1 - 1.9e-11 44.2 1.6 7.2e-11 42.4 0.8 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF202) DUF1319 PF07028.11 ETS59782.1 - 1.2 9.4 3.8 0.62 10.3 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1319) Forkhead PF00250.18 ETS59783.1 - 2.5e-26 91.7 0.1 4.7e-26 90.9 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain SH3_1 PF00018.28 ETS59785.1 - 1.4e-09 37.4 0.3 2.2e-09 36.8 0.3 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETS59785.1 - 0.0064 16.2 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ETS59785.1 - 0.039 13.8 0.1 0.065 13.1 0.1 1.3 1 0 0 1 1 1 0 Variant SH3 domain Nop PF01798.18 ETS59786.1 - 1.3e-84 283.2 0.1 1.3e-84 283.2 0.1 2.0 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ETS59786.1 - 3.7e-15 56.1 0.2 3.7e-15 56.1 0.2 2.6 2 0 0 2 2 2 1 NOP5NT (NUC127) domain CDC45 PF02724.14 ETS59786.1 - 3 6.0 18.2 4.7 5.4 18.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Proteasome PF00227.26 ETS59787.1 - 2.6e-48 164.0 2.6 4.1e-45 153.6 2.6 2.1 1 1 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ETS59787.1 - 5.7e-15 54.7 0.4 1.1e-14 53.7 0.4 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Cpn60_TCP1 PF00118.24 ETS59788.1 - 6.5e-147 490.1 13.7 7.4e-147 489.9 13.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 ETS59788.1 - 0.071 12.6 0.0 0.15 11.6 0.0 1.5 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat DHBP_synthase PF00926.19 ETS59789.1 - 4.3e-81 271.1 0.0 5e-81 270.8 0.0 1.1 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase TPR_2 PF07719.17 ETS59790.1 - 7.4e-08 31.9 33.6 0.21 11.8 0.0 10.3 12 0 0 12 12 12 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETS59790.1 - 9.5e-06 25.2 16.0 0.055 13.3 0.9 6.2 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETS59790.1 - 4.7e-05 23.3 13.2 21 5.6 0.0 8.6 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETS59790.1 - 0.0016 19.1 1.9 0.015 15.9 0.2 11.5 10 2 0 10 10 10 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETS59790.1 - 0.0047 16.6 15.3 0.016 14.9 0.1 6.9 8 0 0 8 8 8 1 TPR repeat TPR_14 PF13428.6 ETS59790.1 - 0.1 13.5 0.1 0.25 12.3 0.4 12.8 12 2 1 13 13 13 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETS59790.1 - 6.1 7.7 28.1 0.66 10.7 0.1 9.6 11 0 0 11 11 11 0 Tetratricopeptide repeat SNO PF01174.19 ETS59791.1 - 9.7e-52 175.6 0.0 2.9e-42 144.6 0.0 2.1 2 0 0 2 2 2 2 SNO glutamine amidotransferase family GATase_3 PF07685.14 ETS59791.1 - 1.6e-10 40.9 0.0 2.4e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_S51 PF03575.17 ETS59791.1 - 0.00011 21.9 0.0 0.00017 21.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 ETS59791.1 - 0.0023 17.8 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family GATase PF00117.28 ETS59791.1 - 0.0028 17.4 0.1 0.18 11.5 0.0 2.1 2 0 0 2 2 2 1 Glutamine amidotransferase class-I BPL_N PF09825.9 ETS59791.1 - 0.2 10.7 0.0 2.1 7.4 0.0 2.0 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal PIP5K PF01504.18 ETS59792.1 - 4e-35 121.4 0.0 1.4e-34 119.6 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase XPG_N PF00752.17 ETS59792.1 - 0.13 12.7 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 XPG N-terminal domain CENP-B_dimeris PF09026.10 ETS59792.1 - 4.9 7.6 10.2 2 8.8 6.8 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Ric8 PF10165.9 ETS59793.1 - 9.4e-132 440.3 0.0 1.3e-131 439.9 0.0 1.2 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn PIG-X PF08320.12 ETS59794.1 - 1.4e-22 80.6 1.2 6.3e-22 78.5 1.2 1.8 1 1 0 1 1 1 1 PIG-X / PBN1 Lactamase_B_4 PF13691.6 ETS59794.1 - 0.19 11.5 0.2 0.63 9.8 0.0 1.9 2 0 0 2 2 2 0 tRNase Z endonuclease SNF2_N PF00176.23 ETS59796.1 - 5.9e-62 209.4 0.0 3.9e-60 203.4 0.0 2.3 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS59796.1 - 7e-18 65.0 0.0 3.7e-17 62.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Hep_59 PF07052.11 ETS59796.1 - 0.35 11.6 2.2 1.2 10.0 2.2 1.9 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 ADH_N PF08240.12 ETS59797.1 - 1.2e-24 86.3 2.3 1.2e-24 86.3 2.3 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS59797.1 - 3.2e-22 78.9 0.5 6.4e-22 77.9 0.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ETS59797.1 - 0.0011 18.2 1.1 0.002 17.4 1.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ETS59797.1 - 0.019 14.3 0.1 0.036 13.4 0.1 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.18 ETS59797.1 - 0.091 13.0 0.2 0.16 12.2 0.2 1.4 1 0 0 1 1 1 0 TrkA-N domain Asp PF00026.23 ETS59798.1 - 1.5e-07 31.2 0.0 0.037 13.4 0.0 3.2 3 1 0 3 3 3 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS59798.1 - 0.014 15.6 0.9 0.032 14.5 0.0 1.9 2 0 0 2 2 2 0 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS59798.1 - 0.042 14.5 0.8 6 7.6 0.2 3.0 2 1 0 2 2 2 0 Aspartyl protease Mur_ligase_M PF08245.12 ETS59799.1 - 0.094 12.7 0.0 0.28 11.1 0.0 1.8 2 0 0 2 2 2 0 Mur ligase middle domain DltD PF04914.12 ETS59799.1 - 0.23 10.8 3.8 0.37 10.1 3.8 1.2 1 0 0 1 1 1 0 DltD protein AAA_11 PF13086.6 ETS59799.1 - 4.3 7.0 10.3 9.3 5.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Collagen PF01391.18 ETS59799.1 - 9.3 6.1 12.6 0.35 10.7 6.3 1.9 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) Glyco_hydro_cc PF11790.8 ETS59800.1 - 8.7e-61 205.5 8.5 1.1e-60 205.2 8.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_53 PF07745.13 ETS59800.1 - 0.0016 17.5 0.2 0.0016 17.5 0.2 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 53 Glyco_hydro_2_C PF02836.17 ETS59800.1 - 0.0032 16.6 0.1 0.0059 15.7 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Med13_C PF06333.12 ETS59802.1 - 3.5e-13 49.5 0.2 3.5e-13 49.5 0.2 5.8 5 1 1 6 6 6 2 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 ETS59802.1 - 0.28 10.9 4.0 1.1 9.0 0.0 3.7 5 0 0 5 5 5 0 MID domain of medPIWI HBS1_N PF08938.10 ETS59802.1 - 0.57 10.5 3.2 0.52 10.6 1.4 1.8 2 0 0 2 2 2 0 HBS1 N-terminus PPR_2 PF13041.6 ETS59803.1 - 3.5e-48 161.6 0.0 4.8e-09 36.3 0.0 12.1 9 2 4 13 13 13 7 PPR repeat family PPR PF01535.20 ETS59803.1 - 5.2e-32 107.8 8.6 0.00034 20.7 0.0 14.4 16 1 0 16 16 16 4 PPR repeat PPR_1 PF12854.7 ETS59803.1 - 3.3e-23 81.1 3.7 0.00012 21.7 0.0 8.7 9 0 0 9 9 9 5 PPR repeat PPR_3 PF13812.6 ETS59803.1 - 4.3e-21 74.7 0.0 2.1e-07 30.9 0.0 8.8 6 2 2 9 9 9 3 Pentatricopeptide repeat domain PPR_long PF17177.4 ETS59803.1 - 7.2e-16 58.2 3.1 4.6e-11 42.5 0.0 5.7 5 1 0 5 5 5 1 Pentacotripeptide-repeat region of PRORP Methyltransf_11 PF08241.12 ETS59803.1 - 6.2e-14 52.4 0.0 2.4e-13 50.5 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS59803.1 - 1.6e-12 47.9 0.5 1.5e-11 44.8 0.0 3.1 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS59803.1 - 4.7e-10 40.1 0.0 2.7e-09 37.7 0.0 2.4 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS59803.1 - 4.8e-10 39.5 0.0 1.2e-09 38.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS59803.1 - 5.4e-07 29.2 0.0 1.1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ETS59803.1 - 8.5e-07 28.9 0.0 1.9e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TPR_7 PF13176.6 ETS59803.1 - 0.0058 16.6 0.2 5.6 7.2 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat DJ-1_PfpI PF01965.24 ETS59803.1 - 0.0089 15.8 0.1 0.042 13.6 0.0 2.1 2 0 0 2 2 2 1 DJ-1/PfpI family Kinesin PF00225.23 ETS59804.1 - 2.5e-109 365.2 0.0 3.7e-109 364.7 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 ETS59804.1 - 1.3e-42 146.0 4.5 3.3e-34 118.6 0.7 3.5 2 1 1 3 3 3 2 Kinesin-associated DUF3694 PF12473.8 ETS59804.1 - 6.3e-40 137.3 0.0 2.4e-38 132.2 0.0 2.8 2 0 0 2 2 2 1 Kinesin protein Microtub_bd PF16796.5 ETS59804.1 - 1.6e-27 96.2 0.0 4.1e-27 94.9 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 ETS59804.1 - 8.2e-13 48.8 0.0 1.9e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 PH domain KIF1B PF12423.8 ETS59804.1 - 5.1e-07 30.0 1.0 1.3e-06 28.7 1.0 1.8 1 0 0 1 1 1 1 Kinesin protein 1B FHA PF00498.26 ETS59804.1 - 2.7e-05 24.4 0.0 0.00035 20.9 0.0 2.7 3 0 0 3 3 3 1 FHA domain PH_9 PF15410.6 ETS59804.1 - 0.051 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain SSF PF00474.17 ETS59805.1 - 3e-16 59.3 32.6 5.5e-16 58.4 32.6 1.4 1 0 0 1 1 1 1 Sodium:solute symporter family Fungal_trans PF04082.18 ETS59807.1 - 1.1e-20 73.8 0.0 3.1e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS59807.1 - 7.7e-08 32.3 11.1 1.4e-07 31.5 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS59808.1 - 2e-17 63.1 0.1 4.4e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS59808.1 - 1.3e-08 34.8 9.7 2.2e-08 34.1 9.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MINDY_DUB PF04424.13 ETS59809.1 - 8.1e-30 103.3 0.0 3.3e-29 101.3 0.0 1.9 2 0 0 2 2 2 1 MINDY deubiquitinase Aminotran_4 PF01063.19 ETS59809.1 - 1.7e-10 41.2 0.0 1.8e-09 37.8 0.0 2.3 1 1 0 1 1 1 1 Amino-transferase class IV Stm1_N PF09598.10 ETS59809.1 - 7.6 7.5 13.3 0.25 12.2 4.6 3.1 3 0 0 3 3 3 0 Stm1 Pro_isomerase PF00160.21 ETS59810.1 - 1.2e-46 158.9 0.0 1.8e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 ETS59810.1 - 9.9e-06 25.3 7.0 0.003 17.5 1.3 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETS59810.1 - 0.00085 19.0 4.5 0.0013 18.4 0.5 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETS59810.1 - 0.004 17.2 1.7 0.013 15.7 0.3 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETS59810.1 - 0.18 12.1 6.0 1.5 9.2 0.4 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETS59810.1 - 1 10.1 4.0 1.4 9.7 0.8 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETS59810.1 - 2 8.2 7.1 5.5 6.8 0.2 3.8 3 1 1 4 4 4 0 TPR repeat Tcf25 PF04910.14 ETS59811.1 - 2.6e-108 362.2 0.0 3.5e-108 361.8 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 YL1 PF05764.13 ETS59811.1 - 0.01 16.0 19.6 0.024 14.8 19.6 1.6 1 0 0 1 1 1 0 YL1 nuclear protein NST1 PF13945.6 ETS59811.1 - 0.16 12.1 13.4 0.29 11.2 13.4 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator GCOM2 PF15328.6 ETS59811.1 - 0.31 11.4 16.9 0.58 10.5 16.9 1.4 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 TFIIF_alpha PF05793.12 ETS59811.1 - 0.7 8.4 28.1 1.2 7.7 28.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Macoilin PF09726.9 ETS59811.1 - 5.1 5.5 12.0 7 5.1 12.0 1.1 1 0 0 1 1 1 0 Macoilin family CCSAP PF15748.5 ETS59811.1 - 8.7 6.4 18.7 17 5.5 18.7 1.5 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SCO1-SenC PF02630.14 ETS59812.1 - 5.5e-45 152.6 0.0 8.9e-45 151.9 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Eaf7 PF07904.13 ETS59813.1 - 1.5e-07 31.7 4.1 1.5e-07 31.7 4.1 4.1 4 1 0 4 4 4 1 Chromatin modification-related protein EAF7 ACOX PF01756.19 ETS59814.1 - 2.1e-26 92.6 0.1 2.9e-23 82.4 0.0 2.3 2 0 0 2 2 2 2 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ETS59814.1 - 2.4e-14 53.9 0.2 6.3e-14 52.6 0.2 1.7 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ETS59814.1 - 1.2e-09 38.2 0.0 2.3e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Methyltransf_23 PF13489.6 ETS59815.1 - 5.4e-08 32.8 0.0 9.8e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS59815.1 - 4.8e-05 24.0 0.1 0.00023 21.8 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS59815.1 - 0.00057 20.6 0.0 0.0014 19.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS59815.1 - 0.0012 19.4 0.9 0.034 14.8 0.2 3.1 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS59815.1 - 0.0016 18.2 0.0 0.0034 17.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS59815.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 ETS59815.1 - 0.13 11.8 0.1 0.3 10.6 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase small domain Glyco_hydro_38N PF01074.22 ETS59816.1 - 2.2e-69 234.0 0.0 3.2e-69 233.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ETS59816.1 - 3.4e-40 138.4 0.0 4.9e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ETS59816.1 - 2.5e-25 88.5 0.2 7.7e-25 86.9 0.0 1.9 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ETS59816.1 - 4.4e-08 33.1 0.0 9.8e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 ETS59816.1 - 0.005 16.1 0.0 0.0082 15.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 MFS_1 PF07690.16 ETS59817.1 - 9.1e-35 120.2 22.0 1.3e-34 119.7 22.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4064 PF13273.6 ETS59817.1 - 0.14 12.4 8.9 3.9 7.8 4.5 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) DUF2830 PF11125.8 ETS59817.1 - 0.16 12.0 0.9 0.58 10.2 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2830) Fumble PF03630.14 ETS59818.1 - 3e-124 414.5 0.0 4.7e-124 413.9 0.0 1.3 1 0 0 1 1 1 1 Fumble Abhydrolase_1 PF00561.20 ETS59818.1 - 5.2e-20 72.2 0.0 4e-16 59.4 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS59818.1 - 3.9e-16 59.0 0.0 4.2e-13 49.1 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS59818.1 - 4.2e-14 53.7 0.2 4.2e-14 53.7 0.2 3.9 3 1 0 3 3 3 1 Alpha/beta hydrolase family Esterase PF00756.20 ETS59818.1 - 7.4e-06 25.8 0.0 2.2e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 ETS59818.1 - 0.00013 22.0 0.0 0.079 12.8 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold BAAT_C PF08840.11 ETS59818.1 - 0.0004 20.4 0.0 0.1 12.5 0.0 2.4 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 ETS59818.1 - 0.00042 20.0 0.0 0.00089 18.9 0.0 1.4 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Ser_hydrolase PF06821.13 ETS59818.1 - 0.00048 20.0 0.1 0.0024 17.7 0.0 2.2 2 0 0 2 2 2 1 Serine hydrolase Ndr PF03096.14 ETS59818.1 - 0.014 14.1 0.0 0.025 13.3 0.0 1.3 1 0 0 1 1 1 0 Ndr family Peptidase_S9 PF00326.21 ETS59818.1 - 0.043 13.3 0.0 3.9 6.9 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family PGAP1 PF07819.13 ETS59818.1 - 0.081 12.6 0.0 0.76 9.4 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein DUF915 PF06028.11 ETS59818.1 - 0.2 10.9 0.1 1 8.6 0.0 2.1 3 0 0 3 3 3 0 Alpha/beta hydrolase of unknown function (DUF915) HSCB_C PF07743.13 ETS59818.1 - 1.5 9.4 4.2 0.51 10.9 0.9 2.0 2 0 0 2 2 1 0 HSCB C-terminal oligomerisation domain V-SNARE PF05008.15 ETS59819.1 - 2.6e-21 75.8 9.9 3.5e-21 75.3 2.0 2.6 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ETS59819.1 - 5e-17 62.0 6.0 5e-17 62.0 6.0 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETS59819.1 - 0.00027 20.8 0.4 0.00027 20.8 0.4 1.9 2 0 0 2 2 2 1 Sec20 DUF883 PF05957.13 ETS59819.1 - 0.00066 20.2 8.8 0.093 13.3 0.4 3.1 1 1 4 5 5 5 2 Bacterial protein of unknown function (DUF883) Prominin PF05478.11 ETS59819.1 - 0.0021 16.1 3.9 0.0061 14.6 3.9 1.7 1 1 0 1 1 1 1 Prominin DUF4407 PF14362.6 ETS59819.1 - 0.0036 16.7 7.2 0.005 16.2 7.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Fusion_gly PF00523.18 ETS59819.1 - 0.013 13.8 0.8 0.015 13.5 0.1 1.6 2 0 0 2 2 2 0 Fusion glycoprotein F0 PTS_IIA PF02255.16 ETS59819.1 - 0.019 15.0 1.7 3.1 7.9 0.0 2.4 2 0 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit DUF2239 PF09998.9 ETS59819.1 - 0.021 14.6 0.1 0.021 14.6 0.1 1.9 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2239) DotU PF09850.9 ETS59819.1 - 0.065 12.9 1.1 0.29 10.8 0.0 2.3 2 1 1 3 3 3 0 Type VI secretion system protein DotU TBCA PF02970.16 ETS59819.1 - 0.091 13.1 7.1 1.3 9.4 1.3 2.4 2 0 0 2 2 2 0 Tubulin binding cofactor A YukC PF10140.9 ETS59819.1 - 0.11 11.3 0.1 0.11 11.3 0.1 1.6 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC Apolipoprotein PF01442.18 ETS59819.1 - 0.11 12.3 16.6 1.8 8.4 1.7 2.7 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain OppC_N PF12911.7 ETS59819.1 - 0.12 12.3 1.0 0.28 11.2 1.0 1.6 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Orf78 PF06024.12 ETS59819.1 - 0.15 12.4 1.0 0.36 11.2 0.1 2.0 2 0 0 2 2 2 0 Orf78 (ac78) YqjK PF13997.6 ETS59819.1 - 0.19 12.0 3.4 0.15 12.4 0.5 2.1 2 0 0 2 2 2 0 YqjK-like protein YnfE PF17452.2 ETS59819.1 - 0.46 10.8 2.8 3.7 7.9 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized YnfE-like DUF2951 PF11166.8 ETS59819.1 - 0.76 10.0 4.0 0.42 10.8 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) zf-CpG_bind_C PF12269.8 ETS59819.1 - 0.99 9.1 4.9 0.57 9.9 0.4 2.0 2 0 0 2 2 2 0 CpG binding protein zinc finger C terminal domain DUF3391 PF11871.8 ETS59819.1 - 1.4 9.4 12.8 1.5e+03 -0.4 12.8 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Sec8_exocyst PF04048.14 ETS59819.1 - 2.1 8.2 7.2 0.83 9.5 0.9 2.5 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF2203 PF09969.9 ETS59819.1 - 2.2 9.0 11.3 0.76 10.5 1.1 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.15 ETS59819.1 - 3.4 7.2 12.4 2.1e+02 1.3 12.4 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 ETS59819.1 - 4.7 6.5 6.1 5.9 6.2 0.1 2.1 1 1 1 2 2 2 0 FAM76 protein Myotub-related PF06602.14 ETS59820.1 - 3.7e-140 466.8 0.0 4.8e-140 466.5 0.0 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 ETS59820.1 - 0.052 13.1 0.1 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 Protein-tyrosine phosphatase DSPc PF00782.20 ETS59820.1 - 0.1 12.4 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Cation_efflux PF01545.21 ETS59821.1 - 4.4e-27 95.1 9.9 6.1e-27 94.6 9.9 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETS59821.1 - 9e-05 22.5 0.0 0.00018 21.5 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Rrn6 PF10214.9 ETS59822.1 - 1.4e-15 56.9 29.4 9e-09 34.4 14.6 4.4 4 1 0 4 4 4 3 RNA polymerase I-specific transcription-initiation factor COS PF18568.1 ETS59822.1 - 0.21 11.6 0.5 0.56 10.2 0.5 1.7 1 0 0 1 1 1 0 TRIM C-terminal subgroup One Signature domain TMEM132D_C PF15706.5 ETS59823.1 - 0.92 9.3 2.7 2.4 8.0 0.1 2.7 3 1 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Tfb2 PF03849.14 ETS59826.1 - 8.2e-141 469.1 0.0 1e-140 468.8 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ETS59826.1 - 7.8e-22 77.5 0.1 1.8e-21 76.3 0.1 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 ETS59826.1 - 0.0011 19.1 0.0 0.0054 16.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain VIT1 PF01988.19 ETS59827.1 - 8.1e-67 225.2 2.9 1.2e-66 224.7 2.9 1.3 1 0 0 1 1 1 1 VIT family MRC1 PF09444.10 ETS59828.1 - 4.1e-32 111.7 27.0 4.1e-32 111.7 27.0 4.6 5 1 0 5 5 5 1 MRC1-like domain RAMP4 PF06624.12 ETS59829.1 - 5e-08 32.9 6.3 7.1e-07 29.2 1.4 2.4 2 1 0 2 2 2 2 Ribosome associated membrane protein RAMP4 KH_6 PF15985.5 ETS59830.1 - 5.1e-11 42.7 0.1 1.4e-10 41.4 0.0 1.8 2 0 0 2 2 2 1 KH domain Rrp40_N PF18311.1 ETS59830.1 - 2.7e-07 30.4 13.3 5.6e-06 26.2 13.3 2.8 1 1 0 1 1 1 1 Exosome complex exonuclease Rrp40 N-terminal domain Alpha_E1_glycop PF01589.16 ETS59830.1 - 0.028 13.1 0.1 0.037 12.7 0.1 1.1 1 0 0 1 1 1 0 Alphavirus E1 glycoprotein Mito_carr PF00153.27 ETS59831.1 - 2.5e-59 197.2 0.1 3.9e-19 68.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_22 PF03901.17 ETS59832.1 - 2.2e-70 238.0 0.0 2e-54 185.4 0.0 2.9 2 1 0 2 2 2 2 Alg9-like mannosyltransferase family WD40 PF00400.32 ETS59833.1 - 4.2e-09 36.9 8.2 0.00087 20.1 0.1 4.5 5 0 0 5 5 5 2 WD domain, G-beta repeat 3HCDH_N PF02737.18 ETS59833.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Vps26 PF03643.15 ETS59835.1 - 1.4e-130 434.3 4.3 1.8e-130 433.9 4.3 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Trm112p PF03966.16 ETS59835.1 - 6.3e-18 65.1 0.1 1.6e-17 63.9 0.1 1.7 1 0 0 1 1 1 1 Trm112p-like protein Arrestin_C PF02752.22 ETS59835.1 - 0.013 16.0 0.4 0.27 11.7 0.1 2.5 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETS59835.1 - 0.018 15.1 0.2 1.4 9.0 0.0 3.0 3 0 0 3 3 3 0 Arrestin (or S-antigen), N-terminal domain GPI-anchored PF10342.9 ETS59836.1 - 0.00013 22.7 0.1 0.0002 22.1 0.1 1.4 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family RNase_H PF00075.24 ETS59837.1 - 1e-33 116.6 0.0 1.6e-33 115.9 0.0 1.3 1 0 0 1 1 1 1 RNase H Cauli_VI PF01693.16 ETS59837.1 - 4.2e-16 59.0 0.1 7.1e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin RVT_3 PF13456.6 ETS59837.1 - 0.18 11.6 0.0 0.43 10.4 0.0 1.6 2 0 0 2 2 2 0 Reverse transcriptase-like Cytomega_UL20A PF05984.12 ETS59837.1 - 0.3 11.4 2.9 0.51 10.7 0.1 2.3 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein F5_F8_type_C PF00754.25 ETS59838.1 - 0.00012 22.2 0.0 0.00072 19.7 0.0 1.8 1 1 1 2 2 2 1 F5/8 type C domain Laminin_N PF00055.17 ETS59838.1 - 0.00063 19.4 0.0 0.00083 19.0 0.0 1.1 1 0 0 1 1 1 1 Laminin N-terminal (Domain VI) SQS_PSY PF00494.19 ETS59840.1 - 4.7e-81 272.1 8.3 6.9e-81 271.6 8.3 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase PT-VENN PF04829.13 ETS59840.1 - 0.1 12.7 1.4 1.5 8.9 2.4 2.2 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif FAD_binding_1 PF00667.20 ETS59841.1 - 2.4e-56 190.8 0.0 3.6e-56 190.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ETS59841.1 - 1.4e-33 116.1 0.3 3.5e-33 114.8 0.3 1.7 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ETS59841.1 - 3.5e-22 79.1 0.0 1.2e-21 77.3 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain DUF455 PF04305.14 ETS59841.1 - 0.044 13.3 0.0 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF455) ArfGap PF01412.18 ETS59842.1 - 1.1e-41 141.6 2.3 1.4e-41 141.2 2.3 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Med11 PF10280.9 ETS59843.1 - 1.4e-10 41.7 0.0 2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Mediator complex protein Fmp27_WPPW PF10359.9 ETS59843.1 - 0.028 13.3 0.8 0.038 12.8 0.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SPC22 PF04573.12 ETS59844.1 - 3.1e-50 170.0 0.5 3.7e-50 169.7 0.5 1.1 1 0 0 1 1 1 1 Signal peptidase subunit CASP_C PF08172.12 ETS59845.1 - 6.2e-75 251.8 2.3 6.2e-75 251.8 2.3 4.3 3 1 0 4 4 4 2 CASP C terminal ZapB PF06005.12 ETS59845.1 - 0.01 16.3 0.2 0.01 16.3 0.2 8.8 6 3 1 7 7 7 0 Cell division protein ZapB PKcGMP_CC PF16808.5 ETS59845.1 - 0.013 15.3 0.9 0.013 15.3 0.9 5.7 6 1 0 6 6 6 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SlyX PF04102.12 ETS59845.1 - 0.6 10.8 0.1 0.6 10.8 0.1 9.5 6 3 5 11 11 11 0 SlyX CENP-F_leu_zip PF10473.9 ETS59845.1 - 0.6 10.1 68.8 0.1 12.6 19.2 6.0 4 2 2 6 6 6 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 ETS59845.1 - 1 9.8 19.5 0.67 10.4 0.5 6.1 5 2 1 6 6 6 0 Flagella accessory protein C (FlaC) HTH_1 PF00126.27 ETS59845.1 - 4 7.5 14.2 0.066 13.2 2.0 4.0 3 2 1 4 4 4 0 Bacterial regulatory helix-turn-helix protein, lysR family DUF1749 PF08538.10 ETS59846.1 - 5.6e-60 203.0 0.0 5.5e-58 196.4 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 ETS59846.1 - 5e-05 24.0 1.3 9.4e-05 23.1 1.3 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 ETS59846.1 - 0.00054 18.9 0.0 0.0008 18.4 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Ser_hydrolase PF06821.13 ETS59846.1 - 0.00081 19.3 0.1 0.0018 18.1 0.1 1.5 2 0 0 2 2 2 1 Serine hydrolase Peptidase_S9 PF00326.21 ETS59846.1 - 0.0072 15.8 0.1 2.7 7.4 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family DUF900 PF05990.12 ETS59846.1 - 0.012 15.1 0.1 0.017 14.6 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 ETS59846.1 - 0.025 13.8 0.0 0.065 12.5 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 LIDHydrolase PF10230.9 ETS59846.1 - 0.19 11.2 0.0 0.77 9.2 0.0 1.8 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase SKA2 PF16740.5 ETS59847.1 - 0.0033 17.2 14.3 0.28 11.0 0.5 3.4 3 0 0 3 3 3 2 Spindle and kinetochore-associated protein 2 ATG16 PF08614.11 ETS59847.1 - 0.0042 17.3 5.7 0.0042 17.3 5.7 6.4 5 1 2 7 7 5 2 Autophagy protein 16 (ATG16) ZapB PF06005.12 ETS59847.1 - 0.013 15.9 0.3 0.013 15.9 0.3 4.9 4 1 0 4 4 3 0 Cell division protein ZapB Mod_r PF07200.13 ETS59847.1 - 0.015 15.4 18.8 0.11 12.6 11.3 3.0 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein YabA PF06156.13 ETS59847.1 - 0.064 13.9 20.8 0.27 11.9 1.3 4.6 3 1 2 5 5 5 0 Initiation control protein YabA DUF5082 PF16888.5 ETS59847.1 - 0.11 12.8 10.1 0.28 11.5 2.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Spectrin PF00435.21 ETS59847.1 - 0.46 11.0 20.6 1.5 9.4 0.7 4.0 4 0 0 4 4 4 0 Spectrin repeat MCC-bdg_PDZ PF10506.9 ETS59847.1 - 0.8 9.8 5.4 0.65 10.1 1.1 2.8 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Chibby PF14645.6 ETS59847.1 - 1.2 9.6 4.2 2.3 8.6 0.5 2.9 3 0 0 3 3 2 0 Chibby family CENP-F_N PF10481.9 ETS59847.1 - 1.4 8.5 16.8 6.7 6.3 15.7 2.5 2 0 0 2 2 2 0 Cenp-F N-terminal domain Fez1 PF06818.15 ETS59847.1 - 1.6 9.2 20.5 16 5.9 0.1 3.3 3 0 0 3 3 3 0 Fez1 Shugoshin_N PF07558.11 ETS59847.1 - 1.8 8.5 4.4 0.72 9.8 0.7 2.2 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF1664 PF07889.12 ETS59847.1 - 2.7 8.0 8.9 0.88 9.6 1.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETS59847.1 - 3.6 8.1 31.6 2.3 8.7 1.9 4.4 2 1 1 4 4 4 0 Apg6 coiled-coil region GIT_CC PF16559.5 ETS59847.1 - 3.8 7.5 16.9 0.092 12.6 1.0 3.8 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor HALZ PF02183.18 ETS59847.1 - 9.2 6.6 10.7 1 9.6 0.4 3.6 4 0 0 4 4 3 0 Homeobox associated leucine zipper ABA_GPCR PF12430.8 ETS59848.1 - 2.8e-46 157.6 4.8 5.3e-46 156.6 4.8 1.5 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 ETS59848.1 - 4.1e-16 58.8 0.2 3.5e-15 55.8 0.0 2.3 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal DASH_Duo1 PF08651.10 ETS59849.1 - 8.2e-21 73.6 0.2 1.4e-20 72.8 0.2 1.3 1 0 0 1 1 1 1 DASH complex subunit Duo1 DUF21 PF01595.20 ETS59851.1 - 1.4e-38 132.3 2.1 2.8e-38 131.4 0.6 1.9 1 1 1 2 2 2 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETS59851.1 - 2.6e-05 24.6 0.9 0.11 12.9 0.0 3.3 3 1 0 3 3 3 2 CBS domain Aldo_ket_red PF00248.21 ETS59852.1 - 2.2e-62 210.9 0.0 2.5e-62 210.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family Pept_tRNA_hydro PF01195.19 ETS59853.1 - 1.9e-24 86.5 0.0 1.1e-23 84.1 0.0 2.0 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase Methyltransf_31 PF13847.6 ETS59853.1 - 9.6e-10 38.4 0.0 2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS59853.1 - 6.7e-07 29.9 0.7 4.5e-06 27.3 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain MTS PF05175.14 ETS59853.1 - 7.1e-06 25.7 0.0 1.7e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain N6_Mtase PF02384.16 ETS59853.1 - 0.00031 20.1 0.0 0.00051 19.4 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.13 ETS59853.1 - 0.0019 17.6 0.1 0.0031 17.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 ETS59853.1 - 0.0056 16.4 0.0 0.015 15.0 0.0 1.7 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 ETS59853.1 - 0.0071 16.0 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ETS59853.1 - 0.0098 16.5 0.1 0.096 13.3 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS59853.1 - 0.011 16.4 0.0 0.04 14.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain UBA_6 PF18039.1 ETS59853.1 - 0.15 12.0 0.0 0.45 10.5 0.0 1.8 1 0 0 1 1 1 0 UBA-like domain FliT PF05400.13 ETS59853.1 - 8.2 7.3 13.1 0.19 12.5 0.4 3.5 3 0 0 3 3 3 0 Flagellar protein FliT PAC4 PF16093.5 ETS59855.1 - 0.00069 19.7 0.4 0.0012 19.0 0.4 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Ribosomal_S9 PF00380.19 ETS59856.1 - 5.5e-42 143.1 1.6 1.1e-41 142.1 0.7 1.9 2 0 0 2 2 2 1 Ribosomal protein S9/S16 RFX_DNA_binding PF02257.15 ETS59857.1 - 1.2e-22 80.4 0.0 2.5e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ETS59857.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.4 1 0 0 1 1 1 0 Poxvirus D5 protein-like PSK_trans_fac PF07704.11 ETS59857.1 - 0.92 10.3 3.7 0.61 10.9 1.1 2.0 2 0 0 2 2 2 0 Rv0623-like transcription factor BPL_LplA_LipB PF03099.19 ETS59858.1 - 0.0016 18.3 0.0 0.0041 17.0 0.0 1.7 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family PPR_2 PF13041.6 ETS59858.1 - 0.0067 16.6 0.0 3.8 7.8 0.0 2.7 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETS59858.1 - 0.1 12.9 0.0 21 5.6 0.0 3.8 4 0 0 4 4 4 0 PPR repeat DUF3253 PF11625.8 ETS59858.1 - 0.17 12.1 1.6 8.7 6.7 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3253) DEAD PF00270.29 ETS59859.1 - 1.2e-39 135.9 0.0 2.2e-39 135.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS59859.1 - 2e-19 70.0 0.0 5.6e-19 68.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS59859.1 - 6.7e-05 23.0 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ETS59859.1 - 0.0066 16.7 0.8 0.076 13.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain GWT1 PF06423.12 ETS59860.1 - 1.1e-37 129.4 0.0 2.5e-37 128.3 0.0 1.6 1 0 0 1 1 1 1 GWT1 MHYT PF03707.16 ETS59863.1 - 4e-15 55.7 20.0 4.2e-06 26.8 5.0 4.6 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat Med14 PF08638.11 ETS59864.1 - 7.2e-52 175.6 0.1 1.3e-51 174.8 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 DnaJ PF00226.31 ETS59865.1 - 9.3e-14 51.3 1.5 2.1e-13 50.2 1.5 1.6 1 0 0 1 1 1 1 DnaJ domain eIF-3c_N PF05470.12 ETS59866.1 - 1.2e-179 598.5 14.8 1.2e-179 598.5 14.8 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 ETS59866.1 - 3.4e-14 53.2 0.0 1e-13 51.7 0.0 1.9 1 0 0 1 1 1 1 PCI domain DUF2779 PF11074.8 ETS59866.1 - 0.032 14.7 5.6 4.7 7.7 0.1 4.2 3 1 1 4 4 4 0 Domain of unknown function(DUF2779) FeoC PF09012.10 ETS59866.1 - 0.062 13.4 0.1 0.37 10.9 0.0 2.4 2 0 0 2 2 2 0 FeoC like transcriptional regulator DUF4363 PF14276.6 ETS59866.1 - 1.8 8.7 5.7 12 6.1 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4363) CDC45 PF02724.14 ETS59866.1 - 1.9 6.7 15.0 3.8 5.7 15.0 1.5 1 0 0 1 1 1 0 CDC45-like protein OSCP PF00213.18 ETS59867.1 - 1.4e-36 126.2 3.0 1.7e-36 126.0 3.0 1.1 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit baeRF_family11 PF18855.1 ETS59867.1 - 0.092 13.1 0.5 0.23 11.8 0.5 1.6 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 11 SecD-TM1 PF13721.6 ETS59867.1 - 0.12 12.8 0.3 0.91 10.0 0.1 2.2 2 0 0 2 2 2 0 SecD export protein N-terminal TM region GST_N PF02798.20 ETS59868.1 - 1.1e-10 41.7 0.0 2.1e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETS59868.1 - 3.7e-10 40.0 0.0 7.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ETS59868.1 - 5.2e-10 39.6 0.0 1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ETS59868.1 - 8.5e-10 38.7 0.0 1.8e-09 37.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETS59868.1 - 4.8e-07 29.7 0.0 8.1e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS59868.1 - 7.2e-06 26.1 0.0 2e-05 24.7 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain FAA_hydrolase PF01557.18 ETS59869.1 - 4.2e-54 183.5 0.0 6.3e-54 182.9 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Glycos_transf_2 PF00535.26 ETS59871.1 - 3.6e-28 98.5 0.0 5.1e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ETS59871.1 - 1.1e-08 35.3 0.0 1.7e-08 34.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyoxalase PF00903.25 ETS59872.1 - 3.8e-23 82.1 0.2 5.2e-23 81.6 0.2 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ETS59872.1 - 2.6e-08 34.1 0.0 4.4e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ETS59872.1 - 2.9e-06 28.0 0.0 5.8e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.7 ETS59872.1 - 0.00018 21.4 0.2 0.00081 19.3 0.2 1.8 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 ETS59872.1 - 0.00048 20.3 0.0 0.051 13.7 0.0 2.2 1 1 0 2 2 2 1 Glyoxalase-like domain Peptidase_M20 PF01546.28 ETS59873.1 - 1.1e-23 84.0 0.1 2.1e-23 83.1 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 ETS59873.1 - 2.2e-22 78.9 7.5 2.2e-05 25.1 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat M20_dimer PF07687.14 ETS59873.1 - 3.7e-11 42.9 0.0 7e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain Nucleoporin_N PF08801.11 ETS59873.1 - 2.5e-05 23.2 0.0 0.038 12.7 0.0 3.4 2 1 1 3 3 3 2 Nup133 N terminal like ANAPC4_WD40 PF12894.7 ETS59873.1 - 0.0023 18.2 0.1 12 6.3 0.0 4.0 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS59873.1 - 0.13 10.9 0.8 4.2 5.9 0.1 3.0 3 1 1 4 4 4 0 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETS59873.1 - 0.16 10.9 0.0 0.45 9.4 0.0 1.7 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain RNA_pol_Rpc34 PF05158.12 ETS59874.1 - 8.6e-78 262.0 0.5 4.4e-69 233.4 0.0 2.4 2 1 0 2 2 2 2 RNA polymerase Rpc34 subunit YL1 PF05764.13 ETS59874.1 - 0.0007 19.8 24.9 0.0007 19.8 24.9 2.1 2 0 0 2 2 2 1 YL1 nuclear protein TrmB PF01978.19 ETS59874.1 - 0.0079 16.1 1.0 0.039 13.8 0.1 2.5 3 0 0 3 3 3 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 ETS59874.1 - 0.014 15.5 0.3 0.046 13.9 0.3 1.8 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC MarR PF01047.22 ETS59874.1 - 0.03 14.3 0.1 0.071 13.0 0.1 1.7 1 0 0 1 1 1 0 MarR family Lin-8 PF03353.15 ETS59874.1 - 0.062 12.9 14.6 0.13 11.8 14.6 1.5 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 ETS59874.1 - 0.22 8.6 16.8 0.31 8.1 16.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Penicillinase_R PF03965.16 ETS59874.1 - 0.27 11.6 1.6 4.7 7.6 0.1 2.6 1 1 1 2 2 2 0 Penicillinase repressor Glyco_hydro_45 PF02015.16 ETS59875.1 - 4.2e-101 337.2 16.0 5.8e-101 336.7 16.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 FAD_binding_3 PF01494.19 ETS59876.1 - 1.6e-21 76.9 0.6 1.4e-18 67.3 0.6 3.2 1 1 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ETS59876.1 - 1.7e-06 28.5 0.0 1.2e-05 25.8 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETS59876.1 - 4.3e-05 22.9 0.0 8e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS59876.1 - 8.6e-05 22.7 0.0 0.00023 21.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETS59876.1 - 0.00011 22.0 0.1 0.00021 21.0 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ETS59876.1 - 0.00047 19.0 0.0 0.0012 17.6 0.0 1.7 1 0 0 1 1 1 1 HI0933-like protein 3HCDH_N PF02737.18 ETS59876.1 - 0.0014 18.6 0.0 0.0054 16.6 0.0 2.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 ETS59876.1 - 0.0036 16.5 1.0 0.0041 16.3 0.1 1.5 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ETS59876.1 - 0.039 13.0 0.0 0.079 12.0 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain DUF2408 PF10303.9 ETS59876.1 - 0.078 13.6 1.1 0.21 12.2 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) AlaDh_PNT_C PF01262.21 ETS59876.1 - 0.12 11.7 0.1 0.27 10.5 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain SE PF08491.10 ETS59876.1 - 0.14 11.2 0.0 0.64 9.0 0.0 2.1 2 1 0 2 2 2 0 Squalene epoxidase NAD_binding_7 PF13241.6 ETS59876.1 - 0.15 12.5 0.0 0.6 10.6 0.0 2.0 1 0 0 1 1 1 0 Putative NAD(P)-binding DMPK_coil PF08826.10 ETS59876.1 - 0.66 10.1 4.9 1.5 8.9 4.9 1.6 1 0 0 1 1 1 0 DMPK coiled coil domain like Acyl_transf_3 PF01757.22 ETS59879.1 - 3.4e-36 125.0 28.5 3.4e-36 125.0 28.5 3.1 3 0 0 3 3 3 1 Acyltransferase family Glyco_trans_2_3 PF13632.6 ETS59879.1 - 1.6e-29 103.2 2.4 1.6e-29 103.2 2.4 3.9 3 1 1 4 4 4 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ETS59879.1 - 7.8e-13 48.8 0.0 1.3e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Fumarate_red_C PF02300.17 ETS59880.1 - 0.48 10.5 4.2 1.4 9.0 4.2 1.8 1 0 0 1 1 1 0 Fumarate reductase subunit C Cellulase PF00150.18 ETS59881.1 - 0.00015 21.3 0.1 0.3 10.5 0.0 2.1 2 0 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Rota_VP4_MID PF17477.2 ETS59881.1 - 0.059 12.7 0.0 0.096 12.0 0.0 1.3 1 0 0 1 1 1 0 Rotavirus VP4 membrane interaction domain Pkinase PF00069.25 ETS59882.1 - 2.2e-43 148.5 0.0 3.2e-43 148.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59882.1 - 1.3e-24 86.9 0.0 1.8e-24 86.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase CAP_GLY PF01302.25 ETS59883.1 - 1.7e-16 60.0 0.4 2.7e-16 59.3 0.4 1.3 1 0 0 1 1 1 1 CAP-Gly domain PI3_PI4_kinase PF00454.27 ETS59884.1 - 1.8e-33 116.4 0.0 5.2e-33 114.9 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pkinase PF00069.25 ETS59885.1 - 2.4e-31 109.1 0.0 5.4e-25 88.2 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59885.1 - 7.8e-17 61.4 0.0 4.6e-14 52.3 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS59885.1 - 2.7e-05 23.6 0.0 4.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ETS59885.1 - 0.083 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family RBR PF17208.3 ETS59885.1 - 7.5 7.3 10.5 0.35 11.6 2.0 3.0 2 0 0 2 2 2 0 RNA binding Region Pex16 PF08610.10 ETS59886.1 - 2.8e-116 388.2 0.0 3.9e-116 387.7 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Pkinase PF00069.25 ETS59887.1 - 1.1e-60 205.2 0.0 1.4e-60 204.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59887.1 - 1.2e-39 136.2 0.0 1.6e-39 135.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS59887.1 - 2.5e-05 23.7 0.0 4.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ETS59887.1 - 0.0069 15.4 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETS59887.1 - 0.01 15.8 1.4 0.23 11.3 0.0 2.8 3 1 0 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETS59887.1 - 0.015 14.1 0.0 0.027 13.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase NinB PF05772.12 ETS59887.1 - 0.13 12.1 0.6 0.24 11.2 0.6 1.3 1 0 0 1 1 1 0 NinB protein TMEM213 PF15192.6 ETS59887.1 - 0.13 12.2 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 TMEM213 family MmgE_PrpD PF03972.14 ETS59888.1 - 1.4e-147 491.8 0.1 2.1e-147 491.2 0.1 1.2 1 0 0 1 1 1 1 MmgE/PrpD family DUF3425 PF11905.8 ETS59889.1 - 1.1e-08 35.1 0.0 2.5e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) HTH_33 PF13592.6 ETS59889.1 - 0.055 13.1 0.3 0.3 10.8 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn helix PPR_3 PF13812.6 ETS59890.1 - 2.8e-13 49.7 0.8 7.3e-05 22.8 0.0 6.3 5 2 2 7 7 7 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETS59890.1 - 3.2e-11 43.3 0.3 7.2e-05 22.9 0.0 6.1 6 1 2 8 8 8 3 PPR repeat family PPR PF01535.20 ETS59890.1 - 0.00011 22.2 2.9 25 5.4 0.1 6.6 8 0 0 8 8 8 1 PPR repeat PPR_long PF17177.4 ETS59890.1 - 0.00072 19.0 0.0 0.011 15.1 0.0 2.8 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP HrpB1_HrpK PF09613.10 ETS59890.1 - 0.0028 17.3 0.0 0.89 9.2 0.0 2.9 2 0 0 2 2 2 2 Bacterial type III secretion protein (HrpB1_HrpK) KH_1 PF00013.29 ETS59891.1 - 1.1e-88 291.0 22.4 1.4e-11 44.1 0.9 15.2 15 1 0 15 15 15 11 KH domain DUF4112 PF13430.6 ETS59891.1 - 1.8e-30 105.3 1.1 4.2e-30 104.1 1.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) MFS_1 PF07690.16 ETS59891.1 - 7.1e-22 77.8 42.9 5.3e-13 48.6 23.9 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily KH_2 PF07650.17 ETS59891.1 - 9.1e-13 47.9 20.9 0.043 13.6 0.2 9.2 10 0 0 10 10 10 5 KH domain KH_4 PF13083.6 ETS59891.1 - 1.7e-06 27.8 16.1 0.15 12.0 0.0 7.4 7 1 0 7 7 7 2 KH domain SLS PF14611.6 ETS59891.1 - 0.0003 20.7 16.3 0.28 11.0 0.1 6.3 7 0 0 7 7 7 3 Mitochondrial inner-membrane-bound regulator OATP PF03137.20 ETS59891.1 - 0.018 13.4 3.8 1.6 6.9 0.0 2.3 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HicB_lk_antitox PF15919.5 ETS59891.1 - 0.043 13.9 0.5 0.26 11.4 0.2 2.4 2 0 0 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system CDV3 PF15359.6 ETS59891.1 - 0.63 10.5 3.1 2.6 8.5 3.1 2.1 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 Sugar_tr PF00083.24 ETS59893.1 - 5.8e-107 358.4 26.0 6.6e-107 358.2 26.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS59893.1 - 2.2e-17 63.0 45.6 1.7e-15 56.9 15.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily CAP59_mtransfer PF11735.8 ETS59894.1 - 5.2e-69 232.6 0.0 6.9e-69 232.2 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 SLATT_1 PF18181.1 ETS59894.1 - 3.8 7.5 4.7 4.7 7.2 0.1 2.3 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF4637 PF15470.6 ETS59895.1 - 0.3 10.8 3.6 0.97 9.1 0.4 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4637) MFS_1 PF07690.16 ETS59896.1 - 6.7e-28 97.6 32.9 6.7e-28 97.6 32.9 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS59896.1 - 1.1e-11 44.3 5.0 1.1e-11 44.3 5.0 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ETS59896.1 - 0.00023 19.7 2.5 0.00039 19.0 2.5 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2238 PF09997.9 ETS59896.1 - 0.77 9.5 4.1 3.1 7.6 0.5 2.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2238) Sulf_transp PF04143.14 ETS59897.1 - 4.2e-07 29.8 29.7 1.5e-05 24.7 15.8 3.9 2 1 1 3 3 3 2 Sulphur transport Sugar_tr PF00083.24 ETS59898.1 - 7.4e-51 173.4 10.1 9.8e-51 173.0 10.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS59898.1 - 1.3e-12 47.3 23.9 1.9e-12 46.8 23.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily HLH PF00010.26 ETS59898.1 - 0.00014 21.8 0.0 0.00028 20.8 0.0 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TAL_FSA PF00923.19 ETS59899.1 - 1.3e-32 113.3 0.0 1.9e-32 112.8 0.0 1.2 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase CysA_C_terminal PF17850.1 ETS59899.1 - 0.075 13.6 0.4 1.2 9.8 0.1 2.9 3 1 0 3 3 3 0 CysA C-terminal regulatory domain His_Phos_2 PF00328.22 ETS59900.1 - 4.1e-38 131.7 0.0 5e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Exo_endo_phos PF03372.23 ETS59901.1 - 0.00028 20.5 0.2 0.00047 19.8 0.2 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Rad1 PF02144.16 ETS59902.1 - 1.5e-97 325.9 0.0 1.9e-97 325.6 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 CD4-extracel PF09191.10 ETS59902.1 - 0.021 15.2 0.0 0.053 13.9 0.0 1.6 1 0 0 1 1 1 0 CD4, extracellular Pex14_N PF04695.13 ETS59902.1 - 0.042 14.5 2.5 0.12 13.0 2.5 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF2236 PF09995.9 ETS59903.1 - 5.4e-50 170.7 0.6 5.4e-50 170.7 0.6 2.2 3 1 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2236) BP28CT PF08146.12 ETS59905.1 - 9.6e-38 129.5 0.0 1.7e-35 122.2 0.0 3.6 3 0 0 3 3 3 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 ETS59905.1 - 4.4e-15 56.1 2.8 4.4e-15 56.1 2.8 5.6 6 0 0 6 6 6 1 U3 small nucleolar RNA-associated protein 10 HEAT_EZ PF13513.6 ETS59905.1 - 0.00023 21.6 20.5 0.54 10.8 0.6 8.3 8 0 0 8 8 8 2 HEAT-like repeat HEAT PF02985.22 ETS59905.1 - 0.018 15.3 0.9 0.018 15.3 0.9 6.4 6 0 0 6 6 6 0 HEAT repeat Cnd1 PF12717.7 ETS59905.1 - 0.02 14.9 0.6 1.9 8.5 0.0 3.4 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 P5CR_dimer PF14748.6 ETS59905.1 - 0.13 12.5 3.4 2.9 8.2 0.1 4.8 3 0 0 3 3 3 0 Pyrroline-5-carboxylate reductase dimerisation Vac14_Fab1_bd PF12755.7 ETS59905.1 - 0.13 12.8 0.1 29 5.3 0.1 3.8 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETS59905.1 - 0.16 12.1 3.5 1.1 9.5 0.2 3.7 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DASH_Spc19 PF08287.11 ETS59908.1 - 3e-35 121.4 8.5 9.1e-35 119.9 8.5 1.6 1 1 0 1 1 1 1 Spc19 FUSC PF04632.12 ETS59908.1 - 0.053 12.0 6.9 0.054 12.0 6.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Topo-VIb_trans PF09239.11 ETS59908.1 - 0.06 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Topoisomerase VI B subunit, transducer Wtap PF17098.5 ETS59908.1 - 0.062 13.2 2.6 0.24 11.3 2.7 1.8 2 0 0 2 2 2 0 WTAP/Mum2p family SlyX PF04102.12 ETS59908.1 - 0.074 13.7 8.6 4.8 7.9 2.3 3.2 2 1 1 3 3 3 0 SlyX BRE1 PF08647.11 ETS59908.1 - 0.15 12.1 6.8 0.096 12.8 3.0 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase PCRF PF03462.18 ETS59908.1 - 0.22 11.4 2.5 0.25 11.2 1.9 1.4 1 1 0 1 1 1 0 PCRF domain Sec2p PF06428.11 ETS59908.1 - 0.22 11.5 3.5 0.49 10.4 0.6 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p tRNA-synt_His PF13393.6 ETS59908.1 - 0.27 10.5 4.2 0.4 9.9 3.8 1.3 1 1 0 1 1 1 0 Histidyl-tRNA synthetase DUF4337 PF14235.6 ETS59908.1 - 0.67 10.0 3.2 0.64 10.1 1.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF4515 PF14988.6 ETS59908.1 - 0.68 9.7 6.2 0.053 13.4 0.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) DivIC PF04977.15 ETS59908.1 - 3.6 7.4 7.9 8.8 6.2 0.9 2.4 2 0 0 2 2 2 0 Septum formation initiator Spc24 PF08286.11 ETS59908.1 - 7.2 6.9 5.8 7.4 6.9 0.9 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 VASt PF16016.5 ETS59909.1 - 6.6e-38 130.5 0.0 1.2e-37 129.7 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ETS59909.1 - 3.2e-24 85.0 0.0 5.9e-24 84.1 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Wbp11 PF09429.10 ETS59910.1 - 3.1e-14 53.1 16.0 3.1e-14 53.1 16.0 3.0 4 0 0 4 4 4 1 WW domain binding protein 11 NpwBP PF12622.7 ETS59910.1 - 4.3e-14 53.0 12.7 4.3e-14 53.0 12.7 3.1 2 1 0 2 2 2 1 mRNA biogenesis factor Peptidase_C48 PF02902.19 ETS59910.1 - 2.4e-11 43.9 0.1 6.9e-11 42.4 0.0 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Fungal_trans_2 PF11951.8 ETS59910.1 - 0.18 10.6 1.1 0.35 9.6 1.1 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain DUF3450 PF11932.8 ETS59910.1 - 0.2 11.0 15.0 0.33 10.2 15.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF948 PF06103.11 ETS59910.1 - 0.37 11.1 0.7 0.88 9.9 0.7 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 ETS59910.1 - 0.52 9.2 2.5 0.79 8.6 2.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 ETS59910.1 - 5.5 6.1 6.4 7.8 5.6 6.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein Acyltransferase PF01553.21 ETS59911.1 - 1.2e-11 44.4 0.0 3e-05 23.7 0.0 2.5 2 0 0 2 2 2 2 Acyltransferase TTL PF03133.15 ETS59912.1 - 1.1e-45 156.0 0.0 3.3e-45 154.5 0.0 1.7 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family Nro1 PF12753.7 ETS59912.1 - 0.41 9.6 1.9 0.67 8.8 1.9 1.3 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Ank_5 PF13857.6 ETS59914.1 - 8.7e-10 38.7 0.4 2.2e-05 24.7 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS59914.1 - 4.5e-07 30.4 0.1 1.4e-06 28.8 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS59914.1 - 1e-06 29.1 1.6 0.0041 17.7 0.1 3.2 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETS59914.1 - 2.8e-06 27.5 0.2 0.059 13.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETS59914.1 - 1.2e-05 25.3 0.8 0.091 13.4 0.0 4.0 3 1 0 3 3 3 1 Ankyrin repeat Nrap_D4 PF17405.2 ETS59915.1 - 1.2e-58 198.0 0.0 3.2e-58 196.6 0.0 1.7 2 0 0 2 2 2 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D2 PF17403.2 ETS59915.1 - 2.2e-50 170.4 0.0 2.1e-49 167.2 0.0 2.3 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Nrap_D5 PF17406.2 ETS59915.1 - 4.4e-45 153.4 0.0 9.4e-44 149.0 0.0 2.7 3 0 0 3 3 3 1 Nrap protein PAP/OAS1-like domain 5 Nrap PF03813.14 ETS59915.1 - 1.2e-43 148.8 0.0 1.9e-43 148.1 0.0 1.3 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 ETS59915.1 - 4.1e-42 144.0 0.0 7.9e-42 143.0 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 ETS59915.1 - 2.2e-31 108.9 0.0 5e-31 107.7 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 SDA1 PF05285.12 ETS59915.1 - 5.5 6.3 28.0 9.3 5.6 28.0 1.3 1 0 0 1 1 1 0 SDA1 PI31_Prot_N PF11566.8 ETS59916.1 - 7.2e-48 162.5 0.0 9e-48 162.2 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 ETS59916.1 - 3.5e-12 47.3 18.5 3.5e-12 47.3 18.5 3.7 3 1 0 3 3 3 1 PI31 proteasome regulator Adaptin_N PF01602.20 ETS59917.1 - 3e-101 339.5 7.9 4.8e-101 338.9 7.9 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 ETS59917.1 - 1.6e-59 199.4 0.0 4.8e-59 197.9 0.0 1.9 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 ETS59917.1 - 5e-58 195.0 0.1 5e-58 195.0 0.1 2.3 3 0 0 3 3 3 1 Coatomer beta C-terminal region Cnd1 PF12717.7 ETS59917.1 - 3.7e-09 36.8 12.9 2e-07 31.2 0.0 3.9 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETS59917.1 - 9e-09 35.6 7.2 0.029 14.8 0.0 5.0 4 1 1 5 5 5 3 HEAT repeats HEAT PF02985.22 ETS59917.1 - 1.2e-07 31.4 0.3 0.02 15.1 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat DUF5578 PF17741.1 ETS59917.1 - 0.0015 18.0 4.5 0.09 12.2 1.8 2.7 1 1 0 2 2 2 2 Family of unknown function (DUF5578) ParcG PF10274.9 ETS59917.1 - 0.016 15.3 2.9 0.57 10.3 0.1 2.7 2 0 0 2 2 2 0 Parkin co-regulated protein DUF5071 PF16804.5 ETS59917.1 - 0.021 15.1 1.1 0.29 11.4 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF5071) DUF3810 PF12725.7 ETS59917.1 - 0.026 13.9 0.2 0.066 12.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Arm PF00514.23 ETS59917.1 - 0.071 13.2 3.3 42 4.4 0.0 5.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat DUF1664 PF07889.12 ETS59917.1 - 0.96 9.5 3.3 6.4 6.8 0.7 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) MutS_V PF00488.21 ETS59918.1 - 1.2e-65 221.1 0.4 1.9e-65 220.4 0.4 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETS59918.1 - 8e-34 117.5 0.3 4.6e-33 115.1 0.0 2.3 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 ETS59918.1 - 8.1e-34 116.3 0.0 1.8e-33 115.2 0.0 1.6 1 0 0 1 1 1 1 MutS domain I Acetyltransf_13 PF13880.6 ETS59918.1 - 3.1e-16 59.1 0.0 8.1e-16 57.8 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 ETS59918.1 - 1.8e-11 43.6 1.3 4.1e-11 42.5 1.3 1.6 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO MutS_II PF05188.17 ETS59918.1 - 2.1e-10 41.0 0.0 9.3e-10 38.9 0.0 2.2 1 1 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 ETS59918.1 - 1.2e-06 28.8 0.0 2.8e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV Sec63 PF02889.16 ETS59919.1 - 2e-24 86.2 0.0 2.8e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 ETS59919.1 - 9.7e-23 80.8 0.0 2.3e-22 79.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS59919.1 - 3.4e-12 46.7 0.0 1.1e-11 45.0 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS59919.1 - 2.1e-10 40.8 0.0 3.5e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETS59919.1 - 0.004 17.5 0.0 0.23 11.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 ETS59919.1 - 0.082 12.5 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ETS59919.1 - 0.084 13.2 0.0 0.3 11.3 0.0 2.0 1 1 0 1 1 1 0 AAA domain HHH_5 PF14520.6 ETS59919.1 - 0.15 12.7 0.0 0.43 11.2 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain Enolase_C PF00113.22 ETS59920.1 - 1.8e-140 467.3 0.1 2.5e-140 466.9 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ETS59920.1 - 2.8e-58 195.7 0.0 4.6e-58 195.1 0.0 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ETS59920.1 - 6.5e-08 32.4 0.0 9.7e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ETS59920.1 - 0.044 12.9 0.1 0.1 11.7 0.1 1.6 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus EMP24_GP25L PF01105.24 ETS59921.1 - 1.2e-39 136.2 0.1 1.3e-39 136.0 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Trimer_CC PF08954.11 ETS59921.1 - 0.028 14.0 0.1 0.054 13.1 0.1 1.4 1 0 0 1 1 1 0 Trimerisation motif Josephin PF02099.17 ETS59922.1 - 7.5e-47 159.5 1.0 1.2e-46 158.8 0.0 1.8 2 0 0 2 2 2 1 Josephin UIM PF02809.20 ETS59922.1 - 3.1e-05 23.6 25.1 0.064 13.2 1.6 4.5 4 0 0 4 4 4 3 Ubiquitin interaction motif ATG27 PF09451.10 ETS59923.1 - 1.5e-77 261.0 0.0 1.9e-77 260.7 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ETS59923.1 - 0.068 13.3 0.0 9.8 6.3 0.0 2.1 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat Myb_DNA-bind_6 PF13921.6 ETS59924.1 - 0.0024 18.1 0.0 0.004 17.4 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 ETS59924.1 - 0.004 17.2 0.4 0.033 14.2 0.4 2.0 1 1 0 1 1 1 1 Myb/SANT-like DNA-binding domain ABC_tran PF00005.27 ETS59925.1 - 1e-33 116.7 0.1 3.1e-16 60.1 0.0 3.0 2 1 0 2 2 2 2 ABC transporter RLI PF04068.15 ETS59925.1 - 7.2e-14 51.3 5.8 7.2e-14 51.3 5.8 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI SMC_N PF02463.19 ETS59925.1 - 5.1e-11 42.4 5.2 0.0002 20.9 0.5 3.7 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETS59925.1 - 1.1e-08 35.3 4.3 0.26 11.1 1.1 4.2 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ETS59925.1 - 1.1e-05 25.4 2.6 0.11 12.2 0.0 3.3 3 1 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 ETS59925.1 - 1.3e-05 25.6 0.0 0.03 14.7 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ETS59925.1 - 1.6e-05 24.9 0.1 0.2 11.6 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 ETS59925.1 - 1.7e-05 25.1 0.0 0.0058 16.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETS59925.1 - 4.2e-05 24.0 0.1 0.023 15.1 0.0 2.5 2 1 0 2 2 2 1 AAA ATPase domain Fer4 PF00037.27 ETS59925.1 - 5.6e-05 22.8 2.9 5.6e-05 22.8 2.9 2.7 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_10 PF13237.6 ETS59925.1 - 0.00013 22.0 8.8 0.0052 16.9 0.2 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_29 PF13555.6 ETS59925.1 - 0.00018 21.2 0.5 0.51 10.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RNA_helicase PF00910.22 ETS59925.1 - 0.00048 20.5 0.3 0.2 12.1 0.0 3.1 3 0 0 3 3 2 1 RNA helicase NACHT PF05729.12 ETS59925.1 - 0.00069 19.6 1.2 0.057 13.3 0.0 2.4 2 0 0 2 2 2 1 NACHT domain Fer4_6 PF12837.7 ETS59925.1 - 0.00075 19.5 11.3 0.0041 17.1 2.3 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_7 PF12775.7 ETS59925.1 - 0.00081 19.0 0.3 0.011 15.2 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 ETS59925.1 - 0.0014 18.3 0.4 0.47 10.1 0.1 2.4 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ETS59925.1 - 0.0014 17.8 0.0 0.12 11.6 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 ETS59925.1 - 0.0025 18.0 0.8 0.5 10.5 0.0 2.6 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 ETS59925.1 - 0.0025 17.7 0.0 0.49 10.3 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain TsaE PF02367.17 ETS59925.1 - 0.0026 17.8 0.1 0.054 13.5 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_21 PF14697.6 ETS59925.1 - 0.0034 17.5 10.9 0.0077 16.3 10.9 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 ETS59925.1 - 0.0048 17.4 8.1 0.011 16.3 0.2 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain SRP54 PF00448.22 ETS59925.1 - 0.0059 16.2 2.7 0.27 10.8 0.1 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ETS59925.1 - 0.0078 16.5 0.9 1.7 8.9 0.1 2.4 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.6 ETS59925.1 - 0.017 15.3 9.9 0.048 13.8 10.0 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain AAA_18 PF13238.6 ETS59925.1 - 0.024 15.2 0.6 8.1 7.0 0.1 2.9 2 1 1 3 3 3 0 AAA domain VirE PF05272.11 ETS59925.1 - 0.028 14.2 0.0 1.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E SbcCD_C PF13558.6 ETS59925.1 - 0.037 14.3 0.0 12 6.2 0.0 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 ETS59925.1 - 0.042 13.6 0.4 2.6 7.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_16 PF13484.6 ETS59925.1 - 0.058 14.3 0.3 0.058 14.3 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain MMR_HSR1 PF01926.23 ETS59925.1 - 0.06 13.4 0.7 9.8 6.3 0.1 2.7 2 1 0 2 2 2 0 50S ribosome-binding GTPase Thymidylate_kin PF02223.17 ETS59925.1 - 0.069 12.8 0.8 5.2 6.7 0.0 2.9 3 0 0 3 3 3 0 Thymidylate kinase AAA_14 PF13173.6 ETS59925.1 - 0.088 12.9 1.3 22 5.1 0.0 3.3 2 1 0 3 3 3 0 AAA domain MeaB PF03308.16 ETS59925.1 - 0.23 10.4 0.4 1.2 8.1 0.0 2.0 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_5 PF07728.14 ETS59925.1 - 0.23 11.5 1.4 3.1 7.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 ETS59925.1 - 0.26 11.5 0.4 2.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 ETS59925.1 - 0.27 11.1 1.3 7.7 6.4 0.1 3.1 3 0 0 3 3 3 0 NTPase Fer4_8 PF13183.6 ETS59925.1 - 0.33 11.4 0.1 0.33 11.4 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain AAA_23 PF13476.6 ETS59925.1 - 0.56 10.7 11.0 0.11 13.0 0.8 2.7 2 1 1 3 3 3 0 AAA domain Fer4_2 PF12797.7 ETS59925.1 - 2.1 8.6 9.7 0.29 11.3 1.1 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain zf-rbx1 PF12678.7 ETS59927.1 - 2.1e-10 40.7 1.8 2.2e-09 37.5 0.5 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETS59927.1 - 5.1e-10 39.5 5.8 1.3e-08 35.0 2.8 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETS59927.1 - 6.6e-09 35.5 6.6 3.9e-08 33.0 2.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETS59927.1 - 1.3e-06 28.0 2.6 0.0016 18.1 0.2 2.6 2 0 0 2 2 2 2 RING-like zinc finger zf-C3HC4 PF00097.25 ETS59927.1 - 1.2e-05 25.1 3.3 4e-05 23.4 0.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETS59927.1 - 0.00015 21.7 0.5 0.0005 20.1 0.2 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ETS59927.1 - 0.00038 20.3 3.5 0.0014 18.4 1.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETS59927.1 - 0.00039 20.0 0.8 0.00097 18.7 0.8 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 ETS59927.1 - 0.00065 19.6 2.0 0.0011 18.9 0.7 2.1 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETS59927.1 - 0.0051 16.7 1.0 0.0051 16.7 1.0 2.3 3 0 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ETS59927.1 - 0.013 15.6 2.2 0.015 15.3 0.2 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_4 PF14570.6 ETS59927.1 - 0.54 10.1 3.8 0.23 11.3 0.9 1.8 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING-like PF08746.11 ETS59927.1 - 0.57 10.5 3.0 1.1 9.6 3.0 1.4 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 ETS59927.1 - 0.65 10.2 3.4 1.2 9.4 1.0 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 ETS59927.1 - 0.8 9.9 5.8 0.15 12.2 1.7 1.8 2 0 0 2 2 2 0 RING-variant domain FAP PF07174.11 ETS59927.1 - 0.85 9.0 11.8 6.4 6.1 11.7 2.1 2 0 0 2 2 2 0 Fibronectin-attachment protein (FAP) Ribosomal_L7Ae PF01248.26 ETS59928.1 - 8.4e-24 83.1 0.2 1.7e-23 82.2 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ETS59928.1 - 0.0032 17.6 0.0 0.0057 16.7 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 Vfa1 PF08432.10 ETS59928.1 - 5.4 7.3 12.7 3.2 8.1 9.7 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Cwf_Cwc_15 PF04889.12 ETS59928.1 - 5.7 6.6 12.0 0.35 10.6 7.1 1.5 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein GCV_T PF01571.21 ETS59929.1 - 0.11 11.9 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain PBP PF01161.20 ETS59930.1 - 1.7e-09 38.1 0.3 3e-09 37.3 0.3 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein WD40 PF00400.32 ETS59931.1 - 2.6e-17 62.9 15.1 4.5e-07 30.5 0.0 6.4 6 0 0 6 6 6 3 WD domain, G-beta repeat Nup160 PF11715.8 ETS59931.1 - 6.5e-05 21.8 0.1 0.023 13.3 0.0 3.0 2 1 1 3 3 3 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETS59931.1 - 0.00048 20.4 0.1 1.9 8.8 0.0 4.0 2 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ETS59931.1 - 0.00053 19.6 1.9 0.021 14.4 0.3 2.2 1 1 1 2 2 2 2 PQQ-like domain Ge1_WD40 PF16529.5 ETS59931.1 - 0.0063 15.5 0.1 0.29 10.0 0.0 3.2 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ETS59931.1 - 0.039 14.4 0.3 47 4.6 0.0 4.0 5 0 0 5 5 5 0 PQQ-like domain DUF963 PF06131.11 ETS59931.1 - 0.35 10.3 1.9 0.42 10.1 0.4 1.9 2 0 0 2 2 2 0 Schizosaccharomyces pombe repeat of unknown function (DUF963) Clr2 PF10383.9 ETS59932.1 - 3.2e-29 102.6 1.3 4e-28 99.0 0.0 2.6 2 1 0 2 2 2 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 ETS59932.1 - 1.3e-21 77.1 1.1 1.5e-20 73.8 2.7 2.0 2 0 0 2 2 2 1 Transcription-silencing protein, cryptic loci regulator Clr2 WW PF00397.26 ETS59932.1 - 8.9e-09 35.3 1.5 1.7e-08 34.4 1.5 1.5 1 0 0 1 1 1 1 WW domain DUF5323 PF17257.2 ETS59932.1 - 0.081 12.8 2.8 1.6 8.7 0.2 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5323) SYCE1 PF15233.6 ETS59932.1 - 0.083 13.0 1.1 0.17 11.9 1.1 1.4 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 DUF4611 PF15387.6 ETS59932.1 - 0.22 11.8 3.6 0.3 11.3 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4611) RskA PF10099.9 ETS59932.1 - 1.5 9.1 16.1 0.26 11.6 11.3 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DNA_primase_S PF01896.19 ETS59933.1 - 1.5e-50 171.7 0.0 3e-50 170.7 0.0 1.5 1 0 0 1 1 1 1 DNA primase small subunit Ist1 PF03398.14 ETS59934.1 - 1.2e-54 184.6 1.7 1.5e-54 184.3 1.7 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway RNA_pol_Rpc4 PF05132.14 ETS59934.1 - 0.05 14.0 0.6 0.084 13.3 0.6 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETS59934.1 - 1.8 7.2 2.9 2.5 6.8 2.9 1.2 1 0 0 1 1 1 0 Presenilin DnaJ PF00226.31 ETS59935.1 - 1.2e-18 67.0 0.2 5.5e-18 64.9 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain RrnaAD PF00398.20 ETS59936.1 - 8e-21 74.3 0.0 1.8e-20 73.1 0.0 1.6 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Presenilin PF01080.17 ETS59936.1 - 3.6 6.2 4.6 5.1 5.8 4.6 1.1 1 0 0 1 1 1 0 Presenilin Pam17 PF08566.10 ETS59937.1 - 6.2e-64 214.8 0.0 7.9e-64 214.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 DEAD PF00270.29 ETS59938.1 - 3.3e-43 147.5 0.2 4.8e-43 146.9 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS59938.1 - 1.8e-27 95.9 0.7 6e-27 94.2 0.3 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ETS59938.1 - 0.0017 17.8 0.0 0.0034 16.8 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 ETS59938.1 - 0.0033 17.5 0.0 0.0096 15.9 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit RSN1_7TM PF02714.15 ETS59939.1 - 2.9e-72 243.3 20.6 2.9e-72 243.3 20.6 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ETS59939.1 - 1.1e-28 100.0 0.3 1.1e-28 100.0 0.3 3.0 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ETS59939.1 - 1.3e-25 90.6 0.0 2.4e-25 89.8 0.0 1.5 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter AA_permease PF00324.21 ETS59941.1 - 4.3e-134 447.7 38.7 4.9e-134 447.5 38.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS59941.1 - 1.1e-40 139.8 42.2 1.4e-40 139.4 42.2 1.2 1 0 0 1 1 1 1 Amino acid permease IBR PF01485.21 ETS59942.1 - 1.6e-20 73.1 43.3 1e-11 44.9 4.3 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 ETS59942.1 - 0.00013 21.9 1.6 0.00013 21.9 1.6 3.6 3 0 0 3 3 3 2 RING-type zinc-finger zf-RING_2 PF13639.6 ETS59942.1 - 0.00018 21.8 4.8 0.00018 21.8 4.8 4.6 3 1 1 4 4 4 2 Ring finger domain zf-C3HC4 PF00097.25 ETS59942.1 - 0.0011 18.8 5.3 0.0011 18.8 5.3 4.3 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS59942.1 - 0.0021 17.9 38.3 0.0048 16.7 3.3 4.7 3 2 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETS59942.1 - 0.49 10.6 26.0 0.17 12.1 0.4 4.4 4 1 0 4 4 4 0 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 ETS59942.1 - 7.4 6.8 13.8 1.1 9.4 1.7 3.0 2 1 0 2 2 2 0 Zinc-binding RING-finger Ribosomal_L16 PF00252.18 ETS59943.1 - 1.6e-42 144.7 0.0 2e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Ribosomal_L27A PF00828.19 ETS59944.1 - 1.1e-20 74.6 0.0 1.5e-20 74.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF5026 PF16429.5 ETS59944.1 - 0.049 13.7 0.3 0.9 9.7 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5026) Hexapep PF00132.24 ETS59945.1 - 1.5e-12 46.7 11.6 6.5e-07 28.8 0.8 4.0 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ETS59945.1 - 8e-05 22.3 11.8 0.0098 15.6 0.2 3.1 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase ATP_transf PF09830.9 ETS59946.1 - 6.5e-08 32.6 0.0 1.3e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase Sulphotransf PF09037.10 ETS59946.1 - 0.013 15.0 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Stf0 sulphotransferase DUF2884 PF11101.8 ETS59947.1 - 0.3 10.6 1.2 0.52 9.8 0.2 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2884) DUF4134 PF13572.6 ETS59947.1 - 0.81 10.0 0.0 0.81 10.0 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4134) Metallophos PF00149.28 ETS59948.1 - 1.8e-11 44.9 0.1 3.1e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_1 PF00076.22 ETS59950.1 - 1.8e-31 107.8 0.0 5.2e-19 67.8 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ETS59950.1 - 4.3e-14 52.4 2.0 2e-07 31.1 0.1 3.4 3 0 0 3 3 3 2 Poly-adenylate binding protein, unique domain Limkain-b1 PF11608.8 ETS59950.1 - 2.1e-05 24.5 0.0 0.25 11.4 0.0 2.7 2 0 0 2 2 2 2 Limkain b1 Nup35_RRM_2 PF14605.6 ETS59950.1 - 0.082 12.9 0.0 0.95 9.5 0.0 2.6 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Cytochrom_B561 PF03188.16 ETS59951.1 - 1.9e-13 50.7 5.8 1.9e-13 50.7 5.8 2.1 1 1 1 2 2 2 1 Eukaryotic cytochrome b561 DUF2306 PF10067.9 ETS59951.1 - 0.4 10.9 16.9 0.092 12.9 7.9 2.7 1 1 2 3 3 3 0 Predicted membrane protein (DUF2306) DUF4079 PF13301.6 ETS59951.1 - 0.62 10.2 17.0 14 5.8 11.1 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DUF998 PF06197.13 ETS59951.1 - 1.3 8.6 30.1 2.9 7.5 17.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF998) Reticulon PF02453.17 ETS59951.1 - 1.9 8.4 15.5 3 7.8 2.2 2.4 2 1 0 2 2 2 0 Reticulon DUF1345 PF07077.11 ETS59951.1 - 2.9 7.6 18.9 0.055 13.2 2.3 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1345) Gpr1_Fun34_YaaH PF01184.19 ETS59952.1 - 6.7e-29 101.0 21.2 8.3e-29 100.7 21.2 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family 5-FTHF_cyc-lig PF01812.20 ETS59953.1 - 5e-38 130.8 0.0 6.1e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Pribosyltran_N PF13793.6 ETS59954.1 - 3e-43 146.5 0.0 1.7e-42 144.1 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ETS59954.1 - 2.7e-36 125.3 0.9 4.9e-32 111.4 0.2 2.3 2 0 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ETS59954.1 - 2.9e-15 56.1 0.8 3.5e-08 33.1 0.4 2.9 3 0 0 3 3 3 2 Phosphoribosyl transferase domain UPRTase PF14681.6 ETS59954.1 - 0.0098 15.4 0.1 0.016 14.6 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pkinase PF00069.25 ETS59955.1 - 4.1e-67 226.3 0.0 5.4e-67 225.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS59955.1 - 9.8e-34 116.8 0.0 2.9e-33 115.3 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETS59955.1 - 0.00071 18.6 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ETS59955.1 - 0.004 16.5 0.0 0.0073 15.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETS59955.1 - 0.0044 16.4 0.1 0.0096 15.3 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETS59955.1 - 0.011 15.7 0.2 0.042 13.8 0.1 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETS59955.1 - 0.087 11.6 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase GCP_C_terminal PF04130.13 ETS59957.1 - 3e-18 66.3 1.4 5.2e-18 65.6 0.2 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ETS59957.1 - 2.8e-13 50.2 0.0 5.4e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal SHE3 PF17078.5 ETS59957.1 - 0.027 14.2 0.1 0.23 11.1 0.0 2.2 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF4746 PF15928.5 ETS59957.1 - 2.7 7.3 8.0 5.7 6.3 8.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MOZ_SAS PF01853.18 ETS59958.1 - 3.7e-74 248.3 0.0 5e-74 247.8 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ETS59958.1 - 1.6e-20 72.5 1.3 4.2e-20 71.1 1.3 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain PHD PF00628.29 ETS59958.1 - 4.4e-17 61.7 24.4 8.1e-10 38.5 8.9 3.3 2 1 1 3 3 3 2 PHD-finger PHD_4 PF16866.5 ETS59958.1 - 5.8e-05 23.1 5.0 5.8e-05 23.1 5.0 2.8 1 1 1 2 2 2 1 PHD-finger Cwf_Cwc_15 PF04889.12 ETS59958.1 - 6.7 6.4 8.6 2.6 7.7 2.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Profilin PF00235.19 ETS59959.1 - 2.6e-44 150.6 0.2 2.8e-44 150.4 0.2 1.0 1 0 0 1 1 1 1 Profilin TIM PF00121.18 ETS59960.1 - 9.2e-96 319.9 0.4 1.1e-95 319.7 0.4 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase CutC PF03932.14 ETS59960.1 - 0.00028 20.4 0.1 0.0015 18.1 0.0 1.9 1 1 1 2 2 2 1 CutC family Glyco_transf_41 PF13844.6 ETS59960.1 - 0.014 13.8 0.1 0.027 12.9 0.1 1.3 1 1 0 1 1 1 0 Glycosyl transferase family 41 MEDS PF14417.6 ETS59960.1 - 0.018 14.9 0.9 1.7 8.5 0.3 2.6 1 1 1 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF5403 PF17395.2 ETS59960.1 - 0.062 13.6 0.5 0.18 12.1 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5403) Thiolase_N PF00108.23 ETS59961.1 - 4.8e-79 265.4 0.8 7.7e-79 264.7 0.8 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETS59961.1 - 3.2e-48 162.4 0.4 3.2e-48 162.4 0.4 2.1 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ETS59961.1 - 7.8e-05 22.4 1.2 0.00023 20.9 1.2 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain bZIP_1 PF00170.21 ETS59962.1 - 7.4e-05 22.8 15.9 0.00012 22.1 15.9 1.3 1 0 0 1 1 1 1 bZIP transcription factor Fmp27_WPPW PF10359.9 ETS59962.1 - 0.21 10.4 4.1 0.28 10.0 4.1 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain bZIP_Maf PF03131.17 ETS59962.1 - 0.32 11.5 13.8 0.56 10.8 13.8 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor SHE3 PF17078.5 ETS59962.1 - 2 8.1 9.3 2.9 7.5 9.3 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 GvpL_GvpF PF06386.11 ETS59962.1 - 6.3 6.6 7.9 9.3 6.1 7.9 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Ribosomal_L37 PF08561.10 ETS59962.1 - 8 7.0 7.8 16 6.0 7.8 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L37 Ribosomal_S21 PF01165.20 ETS59964.1 - 0.081 12.6 0.2 0.081 12.6 0.2 1.8 2 0 0 2 2 2 0 Ribosomal protein S21 zf-UBR PF02207.20 ETS59966.1 - 5.4e-11 42.5 10.2 5.4e-11 42.5 10.2 3.0 4 0 0 4 4 4 1 Putative zinc finger in N-recognin (UBR box) PHD PF00628.29 ETS59966.1 - 0.00025 20.9 0.9 0.00025 20.9 0.9 4.0 4 1 1 5 5 5 1 PHD-finger Pyrid_oxidase_2 PF13883.6 ETS59967.1 - 1.9e-26 93.1 0.1 2.4e-26 92.7 0.1 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Rad51 PF08423.11 ETS59968.1 - 3.7e-128 426.2 0.0 4.4e-128 425.9 0.0 1.0 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ETS59968.1 - 3.3e-11 43.1 0.0 4.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 ETS59968.1 - 1.7e-09 37.5 0.1 2.4e-09 37.0 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 ETS59968.1 - 1.2e-06 28.1 0.1 2.8e-06 26.9 0.1 1.6 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 ETS59968.1 - 1.5e-06 28.7 0.2 4.5e-06 27.2 0.3 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain DnaB_C PF03796.15 ETS59968.1 - 0.0019 17.6 0.1 0.023 14.0 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain PAXNEB PF05625.11 ETS59968.1 - 0.0072 15.5 0.8 0.35 9.9 0.8 2.1 1 1 1 2 2 2 1 PAXNEB protein AAA_24 PF13479.6 ETS59968.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 ETS59968.1 - 0.12 12.4 0.3 0.29 11.2 0.3 1.5 1 0 0 1 1 1 0 single-stranded DNA binding TraI N-terminal subdomain PNRC PF15365.6 ETS59969.1 - 5.9e-06 25.9 7.4 5.9e-06 25.9 7.4 2.7 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif CBFD_NFYB_HMF PF00808.23 ETS59970.1 - 2.6e-09 37.2 0.1 5e-09 36.3 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YtxH PF12732.7 ETS59970.1 - 4.2 8.0 9.5 2.3 8.8 6.8 1.9 2 0 0 2 2 2 0 YtxH-like protein VRR_NUC PF08774.11 ETS59971.1 - 5.6e-23 81.1 0.0 1.3e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 VRR-NUC domain MeaB PF03308.16 ETS59971.1 - 0.1 11.6 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Myosin_head PF00063.21 ETS59972.1 - 5.1e-269 894.1 0.0 5.1e-269 894.1 0.0 2.6 3 0 0 3 3 3 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 ETS59972.1 - 4.7e-09 34.7 135.5 4.7e-09 34.7 135.5 3.4 3 1 0 3 3 3 1 Myosin tail Myosin_N PF02736.19 ETS59972.1 - 2e-08 34.0 0.1 4.5e-08 32.8 0.1 1.6 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Lebercilin PF15619.6 ETS59972.1 - 0.0027 17.4 24.2 0.0027 17.4 24.2 7.7 4 1 3 7 7 7 2 Ciliary protein causing Leber congenital amaurosis disease AAA_22 PF13401.6 ETS59972.1 - 0.095 13.0 0.0 0.095 13.0 0.0 4.8 6 1 1 7 7 7 0 AAA domain Erf4 PF10256.9 ETS59972.1 - 0.15 12.1 0.1 0.8 9.8 0.1 2.2 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family AAA_19 PF13245.6 ETS59972.1 - 0.22 11.9 0.0 0.22 11.9 0.0 3.8 4 1 0 4 4 4 0 AAA domain RabGAP-TBC PF00566.18 ETS59973.1 - 4.2e-19 69.1 0.0 1.4e-10 41.2 0.1 3.3 3 0 0 3 3 3 3 Rab-GTPase-TBC domain DUF3759 PF12585.8 ETS59974.1 - 3e-35 120.1 6.2 3.4e-35 119.9 6.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) PfkB PF00294.24 ETS59976.1 - 6.7e-08 32.2 0.0 0.00037 19.9 0.0 2.1 2 0 0 2 2 2 2 pfkB family carbohydrate kinase WD40 PF00400.32 ETS59978.1 - 2.3e-55 183.3 17.8 5.7e-09 36.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 ETS59978.1 - 1.8e-26 92.3 5.1 2.8e-26 91.6 5.1 1.3 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 ETS59978.1 - 9.2e-24 83.6 0.7 7.6e-06 26.1 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETS59978.1 - 6.9e-11 42.0 0.0 0.0013 18.1 0.0 4.2 5 0 0 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 ETS59978.1 - 1.3e-07 30.9 0.7 0.52 9.2 0.0 5.8 2 2 5 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETS59978.1 - 3.1e-05 22.8 0.3 0.93 8.1 0.0 3.5 2 1 2 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETS59978.1 - 0.00063 19.6 0.0 17 5.5 0.0 5.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETS59978.1 - 0.0018 17.6 0.2 0.74 9.1 0.0 3.7 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETS59978.1 - 0.0019 16.8 0.2 0.57 8.7 0.0 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF5046 PF16465.5 ETS59978.1 - 0.0066 15.9 0.1 1.1 8.6 0.0 2.7 1 1 1 2 2 2 1 Domain of unknown function (DUF5046) DUF1391 PF07151.12 ETS59978.1 - 0.02 14.7 0.3 0.042 13.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1391) GAS PF13851.6 ETS59978.1 - 0.029 13.7 0.5 0.05 13.0 0.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Bystin PF05291.11 ETS59979.1 - 2.9e-132 440.4 0.0 3.7e-132 440.0 0.0 1.1 1 0 0 1 1 1 1 Bystin Ribosomal_L15e PF00827.17 ETS59979.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal L15 GPP34 PF05719.11 ETS59980.1 - 1.1e-74 250.9 0.0 1.4e-74 250.6 0.0 1.3 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) POP1 PF06978.11 ETS59981.1 - 1.7e-28 100.0 26.5 1.2e-16 61.4 10.6 3.4 2 1 1 3 3 3 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 ETS59981.1 - 1.1e-18 67.4 2.6 1.1e-18 67.3 0.2 2.3 2 0 0 2 2 2 1 POPLD (NUC188) domain SRP40_C PF05022.12 ETS59983.1 - 1.3e-28 99.6 0.6 3.7e-28 98.2 0.6 1.8 1 0 0 1 1 1 1 SRP40, C-terminal domain adh_short PF00106.25 ETS59984.1 - 3.3e-35 121.3 0.0 4.2e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS59984.1 - 2.7e-26 92.6 0.0 4.8e-26 91.8 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS59984.1 - 1.2e-08 35.0 0.2 7.7e-06 25.9 0.1 2.2 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 ETS59984.1 - 0.12 11.8 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS59984.1 - 0.25 10.3 0.0 0.37 9.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Kelch_4 PF13418.6 ETS59985.1 - 1.6e-36 124.1 11.1 2.6e-05 24.2 0.1 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ETS59985.1 - 7.6e-32 108.6 1.1 4.9e-06 26.0 0.0 6.3 6 0 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 ETS59985.1 - 1.4e-31 107.9 3.6 2.1e-05 24.4 0.0 6.4 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ETS59985.1 - 1.2e-29 101.9 5.6 2.8e-07 30.6 0.0 6.9 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ETS59985.1 - 1.3e-27 94.6 9.7 1.4e-06 28.0 0.1 6.6 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ETS59985.1 - 6.3e-24 83.4 10.8 1.1e-05 25.5 0.1 6.0 4 1 2 6 6 6 5 Kelch motif PQQ_3 PF13570.6 ETS59985.1 - 0.089 13.3 0.2 15 6.2 0.0 3.6 3 1 1 4 4 4 0 PQQ-like domain Gar1 PF04410.14 ETS59987.1 - 3.5e-30 104.8 8.4 6.5e-30 103.9 0.0 3.3 4 0 0 4 4 4 2 Gar1/Naf1 RNA binding region Unstab_antitox PF09720.10 ETS59987.1 - 0.0026 17.8 1.5 0.007 16.4 1.5 1.8 1 0 0 1 1 1 1 Putative addiction module component zf-AN1 PF01428.16 ETS59989.1 - 1.3e-15 57.2 19.7 2.6e-10 40.3 3.1 3.2 3 0 0 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 ETS59989.1 - 0.0074 16.6 14.3 0.021 15.2 2.2 3.2 3 0 0 3 3 3 2 Tc5 transposase C-terminal domain IBR PF01485.21 ETS59989.1 - 0.034 14.4 1.1 0.034 14.4 1.1 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Malate_synthase PF01274.22 ETS59990.1 - 1.6e-207 689.9 0.0 2e-207 689.6 0.0 1.1 1 0 0 1 1 1 1 Malate synthase Thioredoxin PF00085.20 ETS59990.1 - 2.5e-25 88.4 0.0 4.7e-25 87.6 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ETS59990.1 - 0.00017 22.0 0.1 0.00089 19.7 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 ETS59990.1 - 0.0037 17.0 0.1 0.0078 16.0 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 ETS59990.1 - 0.0043 17.0 0.0 0.0097 15.8 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 ETS59990.1 - 0.0049 17.2 0.0 0.16 12.3 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 ETS59990.1 - 0.0059 16.0 0.0 0.0093 15.4 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 ETS59990.1 - 0.023 14.9 0.0 0.047 13.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Esterase_phd PF10503.9 ETS59990.1 - 0.041 13.4 0.8 1.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Esterase PHB depolymerase Redoxin PF08534.10 ETS59990.1 - 0.063 13.0 0.2 0.38 10.5 0.2 2.1 1 1 0 1 1 1 0 Redoxin HpcH_HpaI PF03328.14 ETS59990.1 - 0.068 12.3 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family HATPase_c PF02518.26 ETS59991.1 - 1.9e-29 102.4 0.0 3.8e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ETS59991.1 - 4.9e-25 87.9 0.0 1.3e-24 86.5 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 ETS59991.1 - 1.5e-20 73.5 2.4 7.1e-06 26.2 0.0 4.6 4 0 0 4 4 4 3 PAS fold HisKA PF00512.25 ETS59991.1 - 8.2e-19 67.4 0.2 3.3e-18 65.5 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 ETS59991.1 - 5.1e-14 52.3 3.4 8.6e-14 51.6 2.1 2.1 2 0 0 2 2 2 1 PAS fold PAS PF00989.25 ETS59991.1 - 1.6e-12 47.4 0.8 0.0012 18.9 0.0 5.1 5 0 0 5 5 5 2 PAS fold PAS_9 PF13426.7 ETS59991.1 - 3.1e-08 33.8 0.0 5.3e-05 23.4 0.0 4.1 4 0 0 4 4 4 1 PAS domain PAS_8 PF13188.7 ETS59991.1 - 1.2e-05 25.2 0.1 0.23 11.5 0.0 3.8 3 0 0 3 3 3 1 PAS domain PAS_11 PF14598.6 ETS59991.1 - 0.02 15.0 0.0 0.052 13.7 0.0 1.6 1 0 0 1 1 1 0 PAS domain AAA_31 PF13614.6 ETS59991.1 - 0.066 13.1 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain PAS_7 PF12860.7 ETS59991.1 - 0.1 12.8 1.0 16 5.7 0.0 3.7 4 0 0 4 4 4 0 PAS fold HATPase_c_3 PF13589.6 ETS59991.1 - 0.15 11.9 0.0 0.31 10.9 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DEAD PF00270.29 ETS59992.1 - 4.2e-41 140.6 0.0 6.8e-22 78.1 0.0 2.3 2 0 0 2 2 2 2 DEAD/DEAH box helicase DUF4217 PF13959.6 ETS59992.1 - 3.8e-23 81.5 0.0 1.1e-22 79.9 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 ETS59992.1 - 1.4e-18 67.3 0.0 6.7e-18 65.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS59992.1 - 1.5e-05 25.1 0.0 7.8e-05 22.7 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ETS59992.1 - 0.01 15.4 4.3 0.09 12.3 0.0 2.3 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain TAF4 PF05236.14 ETS59992.1 - 0.016 15.0 0.3 0.016 15.0 0.3 3.6 3 1 1 4 4 4 0 Transcription initiation factor TFIID component TAF4 family AAA_22 PF13401.6 ETS59992.1 - 0.064 13.5 0.0 0.51 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Cwf_Cwc_15 PF04889.12 ETS59992.1 - 1 9.1 33.7 3 7.5 3.9 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF4611 PF15387.6 ETS59992.1 - 9.1 6.6 23.3 1.9 8.7 2.5 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) SPX PF03105.19 ETS59993.1 - 9.7e-87 292.4 23.4 2.8e-85 287.6 23.4 2.4 1 1 0 1 1 1 1 SPX domain zf-C3HC4 PF00097.25 ETS59993.1 - 8.1e-08 32.0 5.7 1.4e-07 31.3 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS59993.1 - 1.8e-07 30.9 4.7 2.9e-07 30.2 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS59993.1 - 5.4e-06 26.6 7.7 8.9e-06 25.9 7.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 ETS59993.1 - 9.9e-06 25.6 6.1 1.7e-05 24.9 6.1 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETS59993.1 - 6.5e-05 22.7 6.4 0.00012 21.9 6.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETS59993.1 - 0.00011 22.0 7.7 0.00018 21.3 7.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS59993.1 - 0.0002 21.2 5.7 0.00037 20.4 5.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETS59993.1 - 0.00093 19.2 7.3 0.0018 18.2 7.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 ETS59993.1 - 0.0095 15.7 2.1 0.019 14.7 2.1 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ETS59993.1 - 0.016 15.0 2.4 0.035 14.0 2.4 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 ETS59993.1 - 0.075 13.3 6.1 0.2 12.0 6.1 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 ETS59993.1 - 0.53 10.4 4.2 1 9.5 4.2 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 GMC_oxred_N PF00732.19 ETS59994.1 - 1.3e-47 162.6 0.0 2e-47 162.0 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS59994.1 - 6.8e-40 136.9 0.1 1.1e-39 136.3 0.1 1.3 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 ETS59994.1 - 0.00013 22.1 0.1 0.00035 20.8 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETS59994.1 - 0.00093 18.9 0.2 0.0044 16.6 0.1 2.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS59994.1 - 0.0019 17.5 0.0 0.7 9.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS59994.1 - 0.003 16.7 0.1 0.0055 15.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETS59994.1 - 0.0073 15.6 0.1 0.013 14.7 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 ETS59994.1 - 0.013 14.5 0.1 0.022 13.8 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox_2 PF07992.14 ETS59994.1 - 0.021 14.1 0.1 0.16 11.2 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS59994.1 - 0.15 10.7 0.1 0.24 10.0 0.1 1.2 1 0 0 1 1 1 0 HI0933-like protein COG5 PF10392.9 ETS59995.1 - 1.2e-18 67.5 4.9 4.4e-16 59.3 2.7 3.2 2 0 0 2 2 2 2 Golgi transport complex subunit 5 V-SNARE PF05008.15 ETS59995.1 - 0.048 14.0 0.1 0.13 12.6 0.1 1.8 1 0 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus COG2 PF06148.11 ETS59995.1 - 0.17 12.0 1.6 3.8 7.6 1.2 2.8 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 ETS59995.1 - 0.4 10.8 2.2 5.9 7.1 1.0 2.5 2 0 0 2 2 2 0 Vps51/Vps67 dCMP_cyt_deam_1 PF00383.23 ETS59996.1 - 7.5e-26 90.0 2.4 1.2e-25 89.3 2.4 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETS59996.1 - 9.2e-14 51.4 0.7 1.5e-13 50.7 0.7 1.2 1 0 0 1 1 1 1 MafB19-like deaminase AAA_33 PF13671.6 ETS59996.1 - 0.00064 19.9 0.0 0.0013 18.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain SNAD4 PF18750.1 ETS59996.1 - 0.0019 18.3 0.3 0.0035 17.4 0.3 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 AAA_18 PF13238.6 ETS59996.1 - 0.004 17.7 0.0 0.0081 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain APOBEC_N PF08210.11 ETS59996.1 - 0.0067 16.3 0.5 0.011 15.7 0.5 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain NAD1 PF18778.1 ETS59996.1 - 0.008 16.3 0.6 0.013 15.6 0.6 1.3 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC3 PF18771.1 ETS59996.1 - 0.014 15.5 0.2 0.027 14.6 0.2 1.5 1 0 0 1 1 1 0 APOBEC3 Cytidylate_kin PF02224.18 ETS59996.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA PF00004.29 ETS59996.1 - 0.029 14.8 0.0 0.053 13.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) APOBEC2 PF18772.1 ETS59996.1 - 0.067 13.2 0.5 0.12 12.5 0.5 1.3 1 0 0 1 1 1 0 APOBEC2 AAA_5 PF07728.14 ETS59996.1 - 0.077 13.0 0.0 0.23 11.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TFIIIC_sub6 PF10419.9 ETS59998.1 - 5.3e-18 64.7 0.0 8.7e-18 64.0 0.0 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain PH_9 PF15410.6 ETS59999.1 - 2.9e-08 34.1 0.1 1.3e-07 31.9 0.1 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ETS59999.1 - 5e-07 30.2 0.0 1.1e-05 25.9 0.0 2.5 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 ETS59999.1 - 0.033 14.6 0.1 0.26 11.7 0.1 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain Bestrophin PF01062.21 ETS60000.1 - 2.8e-20 72.9 0.0 3.4e-19 69.3 0.0 2.1 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Peptidase_M16_M PF16187.5 ETS60001.1 - 1.1e-97 326.7 0.2 1.7e-97 326.1 0.2 1.3 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ETS60001.1 - 3.6e-44 150.4 0.8 1e-41 142.4 0.0 3.5 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ETS60001.1 - 2.2e-31 109.3 0.0 1.2e-20 74.3 0.0 2.7 3 0 0 3 3 3 2 Peptidase M16 inactive domain DUF4397 PF14344.6 ETS60001.1 - 0.097 13.5 0.0 0.26 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4397) Cyt-b5 PF00173.28 ETS60001.1 - 0.13 12.4 0.1 11 6.3 0.0 2.5 2 0 0 2 2 2 0 Cytochrome b5-like Heme/Steroid binding domain Aa_trans PF01490.18 ETS60002.1 - 6.8e-34 117.3 34.9 7.8e-34 117.1 34.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2061 PF09834.9 ETS60002.1 - 0.019 15.5 0.8 0.019 15.5 0.8 3.4 4 0 0 4 4 4 0 Predicted membrane protein (DUF2061) tRNA-synt_1b PF00579.25 ETS60003.1 - 1.3e-73 247.9 0.0 1.7e-73 247.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) FmiP_Thoc5 PF09766.9 ETS60004.1 - 4.4e-31 108.5 14.5 6.4e-31 108.0 14.5 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 HEPN_SAV2148 PF18725.1 ETS60004.1 - 0.065 12.6 1.1 0.12 11.8 1.1 1.4 1 0 0 1 1 1 0 SAV2148-like HEPN BAR_2 PF10455.9 ETS60004.1 - 0.59 9.2 10.7 3 6.9 10.7 1.9 1 1 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking AAA_23 PF13476.6 ETS60004.1 - 7.5 7.0 12.6 12 6.3 12.6 1.4 1 1 0 1 1 1 0 AAA domain SPA PF08616.10 ETS60005.1 - 7.3e-34 116.1 0.0 1.4e-33 115.2 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 ETS60005.1 - 9.8e-22 77.9 0.3 1.1e-20 74.4 0.3 2.2 1 1 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 ETS60005.1 - 3.1e-08 32.7 0.1 0.015 14.0 0.0 3.6 3 1 1 4 4 4 3 Transport protein Avl9 DUF2347 PF09804.9 ETS60005.1 - 0.00051 19.7 0.0 0.076 12.6 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) Peptidase_C50 PF03568.17 ETS60006.1 - 1.5e-106 356.9 0.0 4.1e-106 355.4 0.0 1.8 1 0 0 1 1 1 1 Peptidase family C50 TPR_8 PF13181.6 ETS60006.1 - 1.2e-06 28.2 1.7 5.2 7.6 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETS60006.1 - 0.00016 21.5 4.9 9.9 6.6 0.0 6.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETS60006.1 - 0.00018 21.3 0.5 1.1 9.4 0.0 4.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS60006.1 - 0.023 14.9 0.4 7 6.9 0.0 4.2 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ETS60006.1 - 0.069 13.8 0.1 0.069 13.8 0.1 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETS60006.1 - 0.26 11.2 6.1 14 5.7 0.2 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETS60006.1 - 0.42 10.5 1.8 1.1e+02 2.8 0.0 4.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 ETS60006.1 - 0.83 10.5 17.7 0.44 11.3 1.2 6.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETS60006.1 - 4.8 7.9 7.3 8.3 7.2 0.1 4.6 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETS60006.1 - 7.3 7.7 17.6 1.5 9.8 0.4 6.5 5 0 0 5 5 4 0 Tetratricopeptide repeat SNF2_N PF00176.23 ETS60007.1 - 9e-56 189.1 0.2 1.6e-54 185.0 0.1 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS60007.1 - 1.4e-15 57.6 0.0 5.4e-15 55.7 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS60007.1 - 2.5e-10 40.6 0.0 6.8e-10 39.2 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETS60007.1 - 2.5e-07 30.6 0.0 6.4e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.25 ETS60007.1 - 5.8e-07 29.3 5.5 5.8e-07 29.3 5.5 2.7 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS60007.1 - 2.9e-06 27.0 6.6 2.9e-06 27.0 6.6 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS60007.1 - 8.8e-06 25.5 5.4 8.8e-06 25.5 5.4 2.3 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETS60007.1 - 8.8e-06 25.5 6.0 8.8e-06 25.5 6.0 2.8 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS60007.1 - 3.6e-05 24.0 7.9 3.6e-05 24.0 7.9 2.6 2 1 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETS60007.1 - 0.00026 20.9 6.7 0.00026 20.9 6.7 2.4 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETS60007.1 - 0.0071 16.4 2.8 0.0071 16.4 2.8 2.8 2 1 1 3 3 2 1 RING-type zinc-finger ERCC3_RAD25_C PF16203.5 ETS60007.1 - 0.034 13.4 0.0 0.077 12.2 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Zn_Tnp_IS91 PF14319.6 ETS60007.1 - 0.058 13.4 12.7 0.13 12.3 1.6 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-ANAPC11 PF12861.7 ETS60007.1 - 0.089 12.9 1.8 0.22 11.6 1.8 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DEAD_2 PF06733.15 ETS60007.1 - 0.096 12.3 0.0 0.75 9.4 0.0 2.5 1 1 0 1 1 1 0 DEAD_2 zf-RING_6 PF14835.6 ETS60007.1 - 0.47 10.4 3.0 1 9.3 3.0 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Ald_Xan_dh_C2 PF02738.18 ETS60008.1 - 3.4e-195 649.7 0.1 4.7e-195 649.2 0.1 1.1 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 ETS60008.1 - 1.1e-36 126.1 0.0 3.9e-36 124.4 0.0 2.0 2 0 0 2 2 2 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 ETS60008.1 - 1.2e-34 118.9 0.0 2.4e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 ETS60008.1 - 4.6e-26 91.0 0.0 1.1e-25 89.8 0.0 1.7 1 0 0 1 1 1 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 ETS60008.1 - 1.4e-25 89.1 0.1 3.6e-25 87.8 0.1 1.8 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 ETS60008.1 - 1.9e-06 27.7 0.0 5.6e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Velvet PF11754.8 ETS60009.1 - 1.2e-20 74.5 1.4 8.6e-17 61.9 0.1 4.4 3 2 1 4 4 4 2 Velvet factor Med8 PF10232.9 ETS60010.1 - 5.7 6.4 9.4 0.58 9.7 0.4 2.5 2 1 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 Lgl_C PF08596.10 ETS60011.1 - 7.4e-24 84.2 0.0 4.6e-19 68.4 0.0 2.6 2 1 0 2 2 2 2 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 ETS60011.1 - 1.9e-05 24.9 0.0 0.021 15.1 0.0 3.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETS60011.1 - 0.081 13.8 9.1 0.23 12.4 0.1 5.0 5 0 0 5 5 5 0 WD domain, G-beta repeat Frtz PF11768.8 ETS60011.1 - 0.15 10.3 0.0 12 4.0 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Glyco_transf_20 PF00982.21 ETS60012.1 - 6.6e-153 509.8 0.0 1.1e-152 509.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ETS60012.1 - 2.3e-65 220.0 0.0 8.2e-65 218.2 0.0 1.9 2 0 0 2 2 2 1 Trehalose-phosphatase ING PF12998.7 ETS60013.1 - 1e-15 58.1 0.0 5.5e-15 55.8 0.0 2.0 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ETS60013.1 - 0.00012 21.9 8.8 0.00022 21.1 8.8 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETS60013.1 - 0.0033 17.0 1.3 0.0059 16.1 1.3 1.4 1 0 0 1 1 1 1 PHD-finger SMC_N PF02463.19 ETS60014.1 - 4.4e-64 215.9 0.0 2.4e-63 213.5 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ETS60014.1 - 4.1e-29 101.3 0.3 1.6e-28 99.3 0.2 2.2 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ETS60014.1 - 2.5e-16 60.4 3.7 5.9e-09 36.2 0.8 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ETS60014.1 - 9.9e-13 49.0 8.8 9.9e-13 49.0 8.8 6.0 3 2 2 5 5 3 1 AAA domain AAA_15 PF13175.6 ETS60014.1 - 2.6e-10 40.6 6.6 2.6e-10 40.6 6.6 3.6 3 1 0 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 ETS60014.1 - 2.8e-08 33.4 0.0 6.8e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 ETS60014.1 - 0.0027 17.9 0.0 0.01 16.0 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit TetR_C_5 PF08360.11 ETS60014.1 - 0.07 13.3 0.1 0.39 10.9 0.0 2.2 2 0 0 2 2 2 0 QacR-like protein, C-terminal region ABC_tran PF00005.27 ETS60014.1 - 0.084 13.4 0.0 0.084 13.4 0.0 5.6 5 2 1 6 6 5 0 ABC transporter NPV_P10 PF05531.12 ETS60014.1 - 0.33 11.4 22.7 21 5.7 0.3 6.7 5 1 0 5 5 5 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ETS60014.1 - 0.58 10.2 37.7 0.92 9.6 1.3 7.1 5 1 1 6 6 6 0 Protein of unknown function (DUF1664) Amidase PF01425.21 ETS60014.1 - 2.3 7.1 10.6 0.32 9.9 5.8 2.0 2 0 0 2 2 2 0 Amidase KH_8 PF17903.1 ETS60016.1 - 2.2e-32 111.0 0.0 4.8e-32 109.9 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 ETS60016.1 - 0.00017 21.3 0.1 0.00038 20.2 0.1 1.5 1 0 0 1 1 1 1 KH domain GRAB PF10375.9 ETS60017.1 - 6.4e-08 32.2 0.7 6.4e-08 32.2 0.7 2.4 2 0 0 2 2 2 1 GRIP-related Arf-binding domain DUF4407 PF14362.6 ETS60017.1 - 0.00019 20.9 9.5 0.00019 20.9 9.5 3.0 1 1 2 3 3 3 1 Domain of unknown function (DUF4407) bZIP_1 PF00170.21 ETS60017.1 - 0.05 13.7 0.5 0.05 13.7 0.5 3.8 3 1 0 3 3 3 0 bZIP transcription factor IFT57 PF10498.9 ETS60017.1 - 0.32 9.9 20.5 1.4 7.8 4.3 2.6 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 ETS60017.1 - 0.4 10.7 6.9 0.42 10.7 1.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 ETS60017.1 - 0.55 10.8 4.6 1.3 9.5 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 Atg14 PF10186.9 ETS60017.1 - 1 8.4 33.8 0.026 13.6 10.0 2.9 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tup_N PF08581.10 ETS60017.1 - 2.1 8.7 8.9 0.31 11.4 0.5 3.5 3 1 0 3 3 3 0 Tup N-terminal YabA PF06156.13 ETS60017.1 - 2.6 8.7 14.1 0.19 12.4 1.2 3.8 2 2 2 4 4 4 0 Initiation control protein YabA FlaC_arch PF05377.11 ETS60017.1 - 2.8 8.4 5.4 7.9 7.0 0.4 3.5 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 ETS60017.1 - 3.6 8.3 25.0 0.04 14.5 3.5 5.1 3 1 2 5 5 5 0 SlyX UPF0184 PF03670.13 ETS60017.1 - 5.5 7.4 11.5 3.2 8.2 0.4 3.9 2 1 1 4 4 4 0 Uncharacterised protein family (UPF0184) TMF_DNA_bd PF12329.8 ETS60017.1 - 7.2 6.7 24.3 1.5 8.8 3.5 4.5 2 2 3 5 5 5 0 TATA element modulatory factor 1 DNA binding TPR_MLP1_2 PF07926.12 ETS60017.1 - 8.4 6.5 40.2 2.9 8.0 3.4 3.9 2 2 1 3 3 3 0 TPR/MLP1/MLP2-like protein TPP_enzyme_N PF02776.18 ETS60018.1 - 4.6e-52 176.1 0.0 4.6e-52 176.1 0.0 3.2 3 1 1 4 4 4 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ETS60018.1 - 2.4e-48 163.8 0.1 8.4e-47 158.8 0.1 2.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ETS60018.1 - 8e-41 139.0 0.4 4.2e-40 136.6 0.1 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Dor1 PF04124.12 ETS60019.1 - 4.8e-20 71.5 2.6 3.8e-16 58.7 1.1 3.1 2 1 0 2 2 2 2 Dor1-like family Ribosomal_S10 PF00338.22 ETS60020.1 - 9.9e-29 99.5 0.5 1.2e-28 99.2 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Ribophorin_II PF05817.14 ETS60021.1 - 2.8e-06 26.2 0.1 2.9e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 Oligosaccharyltransferase subunit Ribophorin II Bax1-I PF01027.20 ETS60021.1 - 0.2 11.5 4.3 0.14 12.0 1.9 1.8 2 0 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 BTB PF00651.31 ETS60022.1 - 8e-13 48.6 0.2 1.4e-09 38.1 0.0 3.6 4 0 0 4 4 4 1 BTB/POZ domain CAP_GLY PF01302.25 ETS60022.1 - 2.2e-08 34.0 0.0 3.9e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Pkinase PF00069.25 ETS60023.1 - 7.2e-71 238.6 0.0 9.7e-71 238.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60023.1 - 2e-41 142.0 0.0 3e-41 141.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 ETS60023.1 - 7.3e-31 106.2 0.0 3.2e-17 62.5 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 ETS60023.1 - 1.4e-07 31.2 0.0 1.1e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ETS60023.1 - 4.4e-05 22.4 0.1 8.2e-05 21.6 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETS60023.1 - 0.012 14.5 0.0 0.019 13.9 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain DUF4520 PF15016.6 ETS60023.1 - 0.14 12.3 0.0 6.8 6.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4520) Kdo PF06293.14 ETS60023.1 - 0.31 10.4 1.2 0.32 10.3 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Aldo_ket_red PF00248.21 ETS60024.1 - 1.4e-44 152.4 0.0 1.7e-44 152.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family RRM_1 PF00076.22 ETS60025.1 - 3.2e-17 62.1 0.0 5.8e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETS60025.1 - 0.001 19.1 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 ETS60025.1 - 0.088 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif HTH_53 PF18606.1 ETS60026.1 - 0.042 13.5 1.3 0.12 12.1 0.3 2.0 2 0 0 2 2 2 0 Zap helix turn helix N-terminal domain DUF5082 PF16888.5 ETS60026.1 - 0.059 13.6 0.2 0.1 12.8 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) adh_short PF00106.25 ETS60031.1 - 4.2e-26 91.6 0.1 7.9e-26 90.7 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60031.1 - 8.9e-18 64.7 0.2 4e-17 62.5 0.2 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ETS60031.1 - 0.0023 17.4 0.6 0.0049 16.4 0.0 1.8 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ETS60031.1 - 0.11 12.4 7.3 0.042 13.8 1.8 2.5 2 1 0 2 2 2 0 KR domain DAO PF01266.24 ETS60034.1 - 7.8e-42 144.1 4.2 1.1e-41 143.6 4.2 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ETS60034.1 - 3.9e-05 23.7 0.7 0.0044 17.0 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ETS60034.1 - 0.00024 20.4 0.0 0.011 15.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS60034.1 - 0.00032 20.1 0.1 0.0086 15.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETS60034.1 - 0.0028 16.9 0.0 0.005 16.1 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 ETS60034.1 - 0.0043 17.2 1.2 0.0099 16.1 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain MCRA PF06100.11 ETS60034.1 - 0.19 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 MCRA family ECH_1 PF00378.20 ETS60035.1 - 1e-23 83.9 0.3 1.3e-23 83.6 0.3 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS60035.1 - 1.6e-06 27.8 0.1 2.3e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Ctr PF04145.15 ETS60036.1 - 3.3e-26 92.7 1.1 1.3e-25 90.8 0.1 1.9 2 0 0 2 2 2 1 Ctr copper transporter family Sensor PF13796.6 ETS60036.1 - 0.09 12.8 5.7 0.062 13.3 1.4 2.0 1 1 1 2 2 2 0 Putative sensor Bromodomain PF00439.25 ETS60037.1 - 3.1e-32 110.5 1.5 6.7e-17 61.3 0.0 2.4 2 0 0 2 2 2 2 Bromodomain TFIIA PF03153.13 ETS60037.1 - 1.2e-05 25.5 40.7 1.2e-05 25.5 40.7 2.7 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 ETS60037.1 - 0.44 10.7 14.2 0.064 13.4 9.5 2.0 2 0 0 2 2 2 0 DDHD domain Exonuc_VII_L PF02601.15 ETS60037.1 - 6.4 6.2 29.1 19 4.7 29.1 1.7 1 0 0 1 1 1 0 Exonuclease VII, large subunit V_ATPase_I PF01496.19 ETS60037.1 - 9.4 4.0 20.6 13 3.5 20.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SCAMP PF04144.13 ETS60038.1 - 1.3e-51 175.3 6.8 1.6e-51 175.1 6.8 1.1 1 0 0 1 1 1 1 SCAMP family DUF3552 PF12072.8 ETS60038.1 - 0.013 15.0 1.0 0.019 14.4 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF4200 PF13863.6 ETS60038.1 - 0.093 13.1 1.7 0.14 12.5 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Peptidase_U4 PF03419.13 ETS60038.1 - 0.3 10.3 7.1 0.41 9.9 7.1 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Septin PF00735.18 ETS60039.1 - 3.6e-113 377.5 1.3 4.6e-113 377.2 1.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ETS60039.1 - 5.6e-09 36.1 0.1 1.5e-08 34.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS60039.1 - 1.5e-06 28.2 0.2 1.7e-05 24.8 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ETS60039.1 - 2.5e-05 23.9 0.7 0.0016 18.0 0.1 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 ETS60039.1 - 2.8e-05 23.5 0.4 7.3e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.23 ETS60039.1 - 4.1e-05 23.7 0.3 0.12 12.5 0.1 2.6 1 1 1 2 2 2 2 Dynamin family NB-ARC PF00931.22 ETS60039.1 - 0.0011 18.2 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ETS60039.1 - 0.0016 18.8 0.5 0.0036 17.7 0.0 1.8 3 0 0 3 3 1 1 AAA ATPase domain IIGP PF05049.13 ETS60039.1 - 0.0018 17.4 0.0 0.0041 16.2 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 ETS60039.1 - 0.0019 18.7 0.3 0.0064 17.0 0.0 1.9 2 1 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETS60039.1 - 0.0021 17.6 0.1 0.039 13.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 ETS60039.1 - 0.0021 17.4 0.0 0.0044 16.4 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family Roc PF08477.13 ETS60039.1 - 0.0053 17.0 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase T2SSE PF00437.20 ETS60039.1 - 0.0069 15.5 0.0 0.012 14.6 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ETS60039.1 - 0.0079 16.5 0.1 0.024 14.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.6 ETS60039.1 - 0.027 14.2 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gtr1_RagA PF04670.12 ETS60039.1 - 0.03 13.7 0.3 0.25 10.7 0.3 2.2 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Microtub_bd PF16796.5 ETS60039.1 - 0.068 13.1 0.4 1.8 8.5 0.1 2.7 1 1 1 3 3 3 0 Microtubule binding AAA_24 PF13479.6 ETS60039.1 - 0.075 12.7 0.4 0.19 11.5 0.1 2.0 2 1 0 2 2 2 0 AAA domain Ras PF00071.22 ETS60039.1 - 0.082 12.5 0.1 0.23 11.0 0.1 1.8 1 0 0 1 1 1 0 Ras family DUF87 PF01935.17 ETS60039.1 - 0.099 12.7 0.4 0.85 9.7 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_23 PF13476.6 ETS60039.1 - 0.41 11.1 3.5 1.7 9.1 3.5 2.0 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ETS60039.1 - 0.8 9.7 4.0 1.5 8.9 0.1 2.9 3 2 0 3 3 3 0 AAA domain FAT PF02259.23 ETS60040.1 - 1.1e-125 419.5 3.2 1.1e-125 419.5 3.2 2.3 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 ETS60040.1 - 4.9e-69 232.9 0.0 9.5e-69 232.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 ETS60040.1 - 1.2e-57 194.3 0.1 3.5e-54 183.0 0.0 4.8 3 1 1 4 4 4 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 ETS60040.1 - 2.7e-43 146.4 0.3 2.7e-43 146.4 0.3 3.8 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain HEAT_2 PF13646.6 ETS60040.1 - 2.3e-16 60.0 12.1 0.004 17.5 0.0 11.5 10 2 2 13 13 12 3 HEAT repeats FATC PF02260.20 ETS60040.1 - 5e-12 45.4 0.2 1.2e-11 44.2 0.2 1.7 1 0 0 1 1 1 1 FATC domain UME PF08064.13 ETS60040.1 - 5e-09 36.0 3.1 0.045 13.7 0.0 6.3 6 1 1 7 7 7 2 UME (NUC010) domain HEAT PF02985.22 ETS60040.1 - 8.8e-07 28.7 18.7 2.2 8.7 0.1 11.2 13 0 0 13 13 12 2 HEAT repeat Vac14_Fab1_bd PF12755.7 ETS60040.1 - 3.4e-05 24.4 0.0 27 5.5 0.0 5.8 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region TPR_19 PF14559.6 ETS60040.1 - 0.00019 21.9 0.4 6 7.5 0.0 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat CLASP_N PF12348.8 ETS60040.1 - 0.0018 17.9 1.2 35 3.8 0.0 6.8 5 3 3 9 9 9 0 CLASP N terminal Cnd1 PF12717.7 ETS60040.1 - 0.002 18.2 0.5 3.1 7.8 0.0 4.5 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.7 ETS60040.1 - 0.0065 16.4 0.6 7.4 6.5 0.0 4.0 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ PF13513.6 ETS60040.1 - 0.022 15.3 27.4 7.3 7.2 0.1 11.0 13 1 1 14 14 10 0 HEAT-like repeat VHS PF00790.19 ETS60040.1 - 0.024 14.5 0.1 1.2 9.0 0.0 3.5 4 0 0 4 4 3 0 VHS domain TPR_1 PF00515.28 ETS60040.1 - 0.03 14.2 0.7 22 5.1 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Cas_Csy4 PF09618.10 ETS60040.1 - 0.093 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) TPR_7 PF13176.6 ETS60040.1 - 0.21 11.7 1.1 29 5.0 0.0 3.9 2 0 0 2 2 2 0 Tetratricopeptide repeat PIN_3 PF13470.6 ETS60040.1 - 0.46 11.3 1.8 3 8.6 0.1 3.1 3 0 0 3 3 2 0 PIN domain Adaptin_N PF01602.20 ETS60040.1 - 0.87 8.1 6.7 5 5.6 0.4 3.8 3 1 1 4 4 4 0 Adaptin N terminal region TPR_2 PF07719.17 ETS60040.1 - 2.2 8.6 10.0 4.9 7.5 0.3 4.9 6 0 0 6 6 4 0 Tetratricopeptide repeat LSM PF01423.22 ETS60041.1 - 4.3e-08 32.7 0.0 1.7e-07 30.8 0.0 1.8 2 0 0 2 2 2 1 LSM domain Sel1 PF08238.12 ETS60042.1 - 4.7e-40 135.1 30.2 8.6e-07 29.4 0.7 7.6 7 0 0 7 7 7 7 Sel1 repeat DPBB_1 PF03330.18 ETS60043.1 - 4.3e-09 36.5 0.3 9.3e-09 35.5 0.3 1.5 1 1 0 1 1 1 1 Lytic transglycolase DUF3568 PF12092.8 ETS60043.1 - 0.41 10.7 2.8 0.54 10.3 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3568) AhpC-TSA PF00578.21 ETS60045.1 - 2.2e-26 92.2 0.0 3.1e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ETS60045.1 - 4.7e-12 45.9 0.0 8.9e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 ETS60045.1 - 0.16 12.1 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme CKS PF01111.19 ETS60046.1 - 3.2e-32 110.6 0.2 4.6e-32 110.1 0.2 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit Sec23_trunk PF04811.15 ETS60047.1 - 1e-74 251.2 0.0 1.7e-74 250.4 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ETS60047.1 - 7.3e-23 80.4 0.5 1.7e-22 79.2 0.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ETS60047.1 - 4.9e-16 59.3 0.0 1.4e-15 57.8 0.0 1.9 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ETS60047.1 - 4.4e-15 55.4 9.1 8.5e-15 54.5 9.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ETS60047.1 - 4.6e-08 32.9 0.0 9.3e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ETS60047.1 - 0.011 15.1 4.4 0.025 14.0 4.4 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain SLATT_4 PF18186.1 ETS60047.1 - 0.1 12.3 0.1 0.49 10.0 0.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 PWI PF01480.17 ETS60048.1 - 2.4e-08 34.1 0.2 2.4e-08 34.1 0.2 1.7 2 0 0 2 2 2 1 PWI domain RRM_1 PF00076.22 ETS60048.1 - 1.5e-05 24.7 0.0 3.7e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mpv17_PMP22 PF04117.12 ETS60049.1 - 3.1e-23 81.8 1.7 6.6e-23 80.7 1.7 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF2723 PF11028.8 ETS60049.1 - 0.015 15.3 0.2 3.6 7.5 0.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2723) TFIIF_alpha PF05793.12 ETS60051.1 - 1.2e-08 34.1 60.2 0.0005 18.8 7.0 3.6 2 1 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cwf_Cwc_15 PF04889.12 ETS60051.1 - 7.3 6.2 37.4 7.9 6.1 15.5 2.6 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein BRCA-2_OB1 PF09103.10 ETS60054.1 - 2e-34 118.2 0.0 3.8e-34 117.3 0.0 1.5 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA2 PF00634.18 ETS60054.1 - 2.9e-10 39.6 0.0 5.7e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 BRCA2 repeat BRCA-2_helical PF09169.10 ETS60054.1 - 4.1e-08 33.1 2.2 3.4e-06 26.9 1.3 3.1 3 0 0 3 3 3 1 BRCA2, helical DUF742 PF05331.11 ETS60054.1 - 0.094 12.5 0.9 0.46 10.3 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF742) SIS PF01380.22 ETS60055.1 - 3e-62 208.2 0.2 2.7e-34 117.8 0.1 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 ETS60055.1 - 2.5e-15 56.9 0.0 5.8e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ETS60055.1 - 1.8e-11 44.0 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 ETS60055.1 - 0.00012 21.0 0.0 0.00021 20.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II YoeB_toxin PF06769.14 ETS60055.1 - 0.18 11.9 0.0 0.48 10.5 0.0 1.7 1 0 0 1 1 1 0 YoeB-like toxin of bacterial type II toxin-antitoxin system 2-oxoacid_dh PF00198.23 ETS60056.1 - 4.5e-55 186.6 0.0 1.1e-54 185.3 0.0 1.6 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ETS60056.1 - 1e-18 66.9 0.1 1.9e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ETS60056.1 - 9.6e-17 61.0 2.1 4.2e-16 59.0 0.2 2.9 3 0 0 3 3 3 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 ETS60056.1 - 0.036 13.9 0.0 0.1 12.5 0.0 1.8 1 0 0 1 1 1 0 Biotin-lipoyl like Helicase_C_2 PF13307.6 ETS60057.1 - 1.6e-55 187.9 0.0 4.4e-55 186.5 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 ETS60057.1 - 9.3e-47 158.9 0.0 1.4e-46 158.3 0.0 1.3 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 ETS60057.1 - 0.0059 16.6 0.0 3.2 7.7 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit NUDIX-like PF09296.11 ETS60057.1 - 0.011 16.3 0.0 0.034 14.8 0.0 1.8 1 0 0 1 1 1 0 NADH pyrophosphatase-like rudimentary NUDIX domain DEAD PF00270.29 ETS60057.1 - 0.035 13.9 0.0 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase PilJ PF13675.6 ETS60057.1 - 0.13 12.3 14.9 0.18 11.9 2.3 3.6 4 0 0 4 4 4 0 Type IV pili methyl-accepting chemotaxis transducer N-term Dsh_C PF12316.8 ETS60057.1 - 1.7 9.0 5.8 1.2 9.5 0.2 2.5 2 1 1 3 3 3 0 Segment polarity protein dishevelled (Dsh) C terminal TPT PF03151.16 ETS60058.1 - 3e-22 79.3 17.0 3.6e-22 79.1 17.0 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family PXA PF02194.15 ETS60059.1 - 3.1e-43 147.8 0.0 1.4e-42 145.7 0.0 2.2 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 ETS60059.1 - 2.2e-26 92.6 0.0 7.9e-26 90.8 0.0 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 ETS60059.1 - 1.8e-13 50.5 0.0 5.8e-13 48.8 0.0 1.9 2 0 0 2 2 2 1 PX domain RGS PF00615.19 ETS60059.1 - 6.7e-06 26.4 0.1 2e-05 24.8 0.1 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain CDH1_2_SANT_HL1 PF18375.1 ETS60059.1 - 0.032 14.9 0.2 0.11 13.1 0.2 1.9 1 0 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 CAML PF14963.6 ETS60059.1 - 0.069 13.3 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand FapA PF03961.13 ETS60059.1 - 0.15 10.6 0.1 0.27 9.8 0.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A GAS PF13851.6 ETS60059.1 - 1.1 8.5 7.5 0.53 9.6 2.9 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Mog1 PF04603.12 ETS60061.1 - 4.8e-40 137.1 0.0 5.7e-40 136.9 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Sterol_MT_C PF08498.10 ETS60062.1 - 2.4e-28 98.2 1.2 3.8e-28 97.6 1.2 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_31 PF13847.6 ETS60062.1 - 1.4e-20 73.7 0.0 1.9e-20 73.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS60062.1 - 3.1e-19 69.4 0.0 5.5e-19 68.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS60062.1 - 6.5e-17 62.0 0.0 1.2e-16 61.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETS60062.1 - 9.4e-16 57.9 0.0 1.3e-15 57.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ETS60062.1 - 2e-13 50.5 0.0 2.9e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS60062.1 - 7.8e-13 49.0 0.0 1.7e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS60062.1 - 3e-08 33.3 0.0 4.9e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_3 PF01596.17 ETS60062.1 - 4.1e-05 22.9 0.0 6.3e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase PCMT PF01135.19 ETS60062.1 - 6.7e-05 22.7 0.0 0.00011 22.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ETS60062.1 - 0.0006 19.4 0.0 0.0013 18.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 ETS60062.1 - 0.0009 18.8 0.1 0.0015 18.2 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 ETS60062.1 - 0.0017 18.1 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.6 ETS60062.1 - 0.0026 18.8 0.0 0.034 15.2 0.0 2.7 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETS60062.1 - 0.003 17.6 0.0 0.0044 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ETS60062.1 - 0.0045 16.6 0.0 0.007 16.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.18 ETS60062.1 - 0.0053 16.1 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltr_RsmB-F PF01189.17 ETS60062.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F PrmA PF06325.13 ETS60062.1 - 0.024 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 ETS60062.1 - 0.057 12.9 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase RrnaAD PF00398.20 ETS60062.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase N2227 PF07942.12 ETS60062.1 - 0.17 11.0 0.1 6.6 5.8 0.0 2.2 1 1 1 2 2 2 0 N2227-like protein Methyltransf_18 PF12847.7 ETS60062.1 - 0.19 11.7 0.0 1.8 8.5 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain DHFR_1 PF00186.19 ETS60063.1 - 6e-28 97.6 0.0 2.2e-27 95.7 0.0 1.8 1 1 0 1 1 1 1 Dihydrofolate reductase TPR_12 PF13424.6 ETS60064.1 - 6.1e-07 29.6 4.0 1.7e-06 28.2 4.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETS60064.1 - 0.0047 16.8 0.1 0.015 15.1 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETS60064.1 - 0.017 15.3 1.4 0.053 13.8 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETS60064.1 - 0.063 13.4 0.2 0.25 11.6 0.2 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETS60064.1 - 0.11 12.6 0.1 0.75 10.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETS60064.1 - 0.26 12.2 0.2 0.26 12.2 0.2 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Aminotran_5 PF00266.19 ETS60065.1 - 7.7e-28 97.5 0.0 1.2e-27 96.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V ABC2_membrane PF01061.24 ETS60066.1 - 5.8e-30 104.3 18.9 1e-29 103.5 18.9 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ETS60066.1 - 1e-25 90.8 0.0 1.6e-25 90.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETS60066.1 - 1.1e-06 28.7 0.0 0.016 15.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETS60066.1 - 6.9e-05 22.5 0.4 0.0003 20.5 0.2 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETS60066.1 - 0.00028 20.8 0.1 0.00054 19.9 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ETS60066.1 - 0.0003 20.4 0.7 0.024 14.2 0.2 2.4 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETS60066.1 - 0.0048 17.3 0.1 0.0084 16.5 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETS60066.1 - 0.023 15.0 0.0 0.045 14.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 ETS60066.1 - 0.033 13.8 0.0 0.056 13.1 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 ETS60066.1 - 0.049 13.5 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 ETS60066.1 - 0.054 14.0 0.1 0.093 13.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ETS60066.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 ETS60066.1 - 0.073 13.2 0.1 0.8 9.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETS60066.1 - 0.078 12.7 0.4 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETS60066.1 - 0.081 13.4 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETS60066.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 ETS60066.1 - 0.15 12.3 0.3 0.3 11.3 0.3 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETS60066.1 - 0.22 11.3 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain Adaptin_N PF01602.20 ETS60067.1 - 6.1e-100 335.2 0.0 5.3e-99 332.1 0.0 2.2 1 1 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETS60067.1 - 3.3e-12 46.7 0.0 5.1e-09 36.4 0.0 3.1 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETS60067.1 - 7e-07 29.6 8.1 0.0033 17.8 0.1 4.2 3 2 0 3 3 3 2 HEAT repeats HEAT PF02985.22 ETS60067.1 - 1.2e-05 25.1 1.9 5.6 7.5 0.0 5.6 5 0 0 5 5 5 1 HEAT repeat AP3D1 PF06375.11 ETS60067.1 - 9.1e-05 22.7 0.6 0.00021 21.6 0.6 1.6 1 1 0 1 1 1 1 AP-3 complex subunit delta-1 RTP1_C1 PF10363.9 ETS60067.1 - 0.012 15.8 0.3 1.4 9.1 0.0 3.2 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3384 PF11864.8 ETS60067.1 - 0.081 11.8 0.1 0.21 10.5 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3384) V-ATPase_H_C PF11698.8 ETS60067.1 - 0.11 12.6 0.2 14 5.8 0.0 3.2 2 1 0 2 2 2 0 V-ATPase subunit H DBD_HTH PF18430.1 ETS60067.1 - 0.31 10.8 1.5 1.6 8.6 0.0 2.6 3 0 0 3 3 3 0 Putative DNA-binding domain Tim54 PF11711.8 ETS60068.1 - 1e-47 162.7 0.3 1e-47 162.7 0.3 3.4 1 1 2 3 3 3 1 Inner membrane protein import complex subunit Tim54 HNOBA PF07701.14 ETS60068.1 - 0.15 11.4 2.5 0.31 10.4 2.5 1.4 1 0 0 1 1 1 0 Heme NO binding associated RNase_PH PF01138.21 ETS60069.1 - 3.3e-25 89.1 0.0 6.1e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Adap_comp_sub PF00928.21 ETS60070.1 - 3.1e-83 279.2 0.0 3.8e-83 278.9 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETS60070.1 - 0.00074 19.5 0.6 0.0014 18.6 0.6 1.5 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 ETS60070.1 - 0.014 14.9 0.1 0.021 14.3 0.1 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Redoxin PF08534.10 ETS60071.1 - 1.9e-09 37.4 0.0 2.3e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ETS60071.1 - 5.5e-06 26.3 0.0 2.4e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 AhpC/TSA family DUF899 PF05988.12 ETS60071.1 - 0.018 14.6 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) LSM PF01423.22 ETS60072.1 - 9.6e-18 63.6 0.9 1.2e-17 63.3 0.9 1.1 1 0 0 1 1 1 1 LSM domain Gemin7 PF11095.8 ETS60072.1 - 0.14 12.0 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) XPG_N PF00752.17 ETS60073.1 - 2.4e-23 82.5 0.0 5e-23 81.5 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ETS60073.1 - 4.3e-23 81.5 0.0 8.7e-23 80.5 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ETS60073.1 - 0.00032 20.3 0.0 0.00052 19.6 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 ETS60073.1 - 0.0043 17.6 0.0 0.0091 16.6 0.0 1.5 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold TPR_2 PF07719.17 ETS60073.1 - 0.15 12.2 0.0 0.44 10.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Glyco_transf_90 PF05686.12 ETS60074.1 - 1.3e-24 86.9 0.0 2.1e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 90 Pmp3 PF01679.17 ETS60075.1 - 4.5e-15 55.6 5.3 7.2e-15 54.9 5.3 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Guanylate_cyc_2 PF09778.9 ETS60076.1 - 0.055 12.8 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 Guanylylate cyclase ERCC4 PF02732.15 ETS60077.1 - 1.1e-20 74.4 0.0 2.8e-20 73.1 0.0 1.8 1 0 0 1 1 1 1 ERCC4 domain ATP-synt_ab PF00006.25 ETS60078.1 - 5e-61 206.1 0.0 1e-60 205.1 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ETS60078.1 - 1.7e-23 82.9 4.3 1.7e-23 82.9 4.3 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 ETS60078.1 - 0.017 14.4 0.3 0.035 13.5 0.3 1.5 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 ETS60078.1 - 0.027 14.4 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ETS60078.1 - 0.039 13.1 0.8 0.1 11.7 0.1 1.8 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 ETS60078.1 - 0.048 13.6 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA PF00004.29 ETS60078.1 - 0.076 13.4 0.0 0.96 9.9 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETS60078.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ETS60078.1 - 0.18 12.2 0.0 0.38 11.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 ETS60078.1 - 0.4 11.0 3.3 0.47 10.8 0.1 2.4 3 0 0 3 3 3 0 AAA domain Cyclin_N PF00134.23 ETS60080.1 - 3.8e-08 33.1 3.3 5e-08 32.7 0.1 2.6 3 1 0 3 3 3 1 Cyclin, N-terminal domain DnaJ PF00226.31 ETS60081.1 - 4.7e-17 61.9 0.1 1.4e-16 60.4 0.1 1.9 2 0 0 2 2 2 1 DnaJ domain Vps54_N PF10475.9 ETS60081.1 - 0.066 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Cyclin_N PF00134.23 ETS60082.1 - 4.8e-13 49.0 0.1 1.7e-12 47.2 0.0 1.9 2 1 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 ETS60082.1 - 1.8e-05 24.7 0.5 4.6e-05 23.4 0.2 1.8 2 0 0 2 2 2 1 Transcription factor TFIIB repeat Cyclin_C PF02984.19 ETS60082.1 - 0.0047 17.0 0.2 1.5 8.9 0.0 2.4 2 0 0 2 2 2 2 Cyclin, C-terminal domain UAA PF08449.11 ETS60083.1 - 5e-46 157.3 5.0 1.6e-45 155.6 5.0 1.7 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETS60083.1 - 3e-10 40.4 23.3 5.7e-08 33.0 5.4 4.3 4 1 0 4 4 4 2 EamA-like transporter family PUNUT PF16913.5 ETS60083.1 - 2.6e-05 23.6 6.1 3.6e-05 23.1 6.1 1.3 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport TPT PF03151.16 ETS60083.1 - 0.00027 20.4 1.9 0.00027 20.4 1.9 2.8 4 0 0 4 4 4 2 Triose-phosphate Transporter family Nuc_sug_transp PF04142.15 ETS60083.1 - 0.00033 19.9 1.6 0.21 10.7 0.1 2.4 2 0 0 2 2 2 2 Nucleotide-sugar transporter CRT-like PF08627.10 ETS60083.1 - 0.00054 19.0 3.7 0.21 10.5 0.3 2.5 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like TMEM234 PF10639.9 ETS60083.1 - 1.1 9.3 4.9 9.2 6.3 0.6 2.7 2 0 0 2 2 2 0 Putative transmembrane family 234 PhyH PF05721.13 ETS60084.1 - 1.2e-05 25.7 0.0 2.1e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Lysine_decarbox PF03641.14 ETS60085.1 - 3.2e-31 108.1 0.1 6e-31 107.3 0.1 1.4 1 0 0 1 1 1 1 Possible lysine decarboxylase ABC_tran PF00005.27 ETS60085.1 - 1.9e-14 54.3 0.0 4.6e-14 53.1 0.0 1.7 1 1 0 1 1 1 1 ABC transporter LDcluster4 PF18306.1 ETS60085.1 - 2.4e-10 40.2 1.6 5.8e-10 39.0 1.6 1.6 1 1 0 1 1 1 1 SLOG cluster4 family AAA_21 PF13304.6 ETS60085.1 - 5.8e-09 36.2 4.1 0.00054 19.9 0.2 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ETS60085.1 - 0.00046 19.8 0.0 0.00079 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ETS60085.1 - 0.00098 18.8 0.0 0.003 17.3 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ETS60085.1 - 0.0052 17.2 0.1 0.011 16.1 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ETS60085.1 - 0.021 15.1 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETS60085.1 - 0.038 14.1 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS60085.1 - 0.05 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 ETS60085.1 - 0.074 12.5 0.0 14 5.1 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETS60085.1 - 0.13 12.7 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ETS60085.1 - 0.15 11.7 0.0 0.21 11.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain Med19 PF10278.9 ETS60085.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Arf PF00025.21 ETS60085.1 - 0.16 11.4 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family L51_S25_CI-B8 PF05047.16 ETS60087.1 - 6.6e-05 22.8 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain ECH_1 PF00378.20 ETS60088.1 - 4.3e-42 144.2 0.0 5.6e-42 143.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS60088.1 - 8.5e-19 68.2 0.0 1.2e-18 67.7 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CBFD_NFYB_HMF PF00808.23 ETS60089.1 - 1.1e-18 67.3 0.1 1.1e-18 67.3 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2458 PF10454.9 ETS60089.1 - 0.006 16.3 0.3 0.0083 15.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) Histone PF00125.24 ETS60089.1 - 0.024 15.0 1.8 0.11 12.9 0.0 2.0 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 YolD PF08863.10 ETS60089.1 - 0.038 14.1 1.9 0.1 12.7 1.1 1.9 2 0 0 2 2 2 0 YolD-like protein DAHP_synth_1 PF00793.20 ETS60090.1 - 1.9e-98 328.7 0.0 2.3e-98 328.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family zf-RING_2 PF13639.6 ETS60091.1 - 7.4e-12 45.4 5.6 1.2e-11 44.7 5.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETS60091.1 - 4.1e-08 32.8 3.9 6.9e-08 32.1 3.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_5 PF14634.6 ETS60091.1 - 1.2e-07 31.5 6.7 2e-07 30.9 6.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS60091.1 - 2.8e-07 30.3 7.6 4.5e-07 29.6 7.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS60091.1 - 3.9e-07 29.8 5.9 6.3e-07 29.2 5.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETS60091.1 - 1.8e-05 24.9 5.3 3.9e-05 23.9 5.3 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETS60091.1 - 3.5e-05 23.7 2.4 6.7e-05 22.8 2.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETS60091.1 - 0.00026 20.8 7.1 0.00042 20.1 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS60091.1 - 0.0029 17.4 6.0 0.0052 16.6 6.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETS60091.1 - 0.14 12.2 2.5 0.26 11.3 2.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETS60091.1 - 0.17 11.5 5.1 0.3 10.7 5.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 ETS60091.1 - 0.36 10.7 5.0 0.66 9.8 5.0 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 ETS60091.1 - 4 7.6 5.3 6.5 6.9 5.3 1.4 1 0 0 1 1 1 0 Zinc-finger Prok-RING_1 PF14446.6 ETS60091.1 - 4.5 7.3 6.4 11 6.0 6.4 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Peroxin-13_N PF04088.13 ETS60092.1 - 9e-48 162.2 0.1 9e-48 162.2 0.1 1.7 2 0 0 2 2 2 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 ETS60092.1 - 1.2e-12 47.2 0.0 2.3e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS60092.1 - 1.5e-11 44.0 0.7 3.1e-11 42.9 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 ETS60092.1 - 9.3e-11 41.2 0.0 1.7e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain WD40 PF00400.32 ETS60093.1 - 5.8e-52 172.5 24.9 4.3e-11 43.2 0.2 8.0 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60093.1 - 1e-14 54.6 0.7 4e-06 27.0 0.0 4.7 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS60093.1 - 1.7e-11 43.5 4.2 0.00047 18.9 0.0 5.6 3 1 2 6 6 6 3 Nucleoporin Nup120/160 LisH_TPL PF17814.1 ETS60093.1 - 0.0014 18.2 0.0 0.003 17.2 0.0 1.6 1 0 0 1 1 1 1 LisH-like dimerisation domain LisH PF08513.11 ETS60093.1 - 0.0034 17.3 0.1 0.0068 16.3 0.1 1.5 1 0 0 1 1 1 1 LisH Nucleoporin_N PF08801.11 ETS60093.1 - 0.0038 16.0 0.2 4.2 6.0 0.0 3.8 2 1 2 4 4 4 1 Nup133 N terminal like DUF2600 PF10776.9 ETS60093.1 - 0.042 12.7 0.0 0.065 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) IF-2B PF01008.17 ETS60094.1 - 2.1e-57 194.5 0.0 2.6e-57 194.2 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DEAD PF00270.29 ETS60095.1 - 8.3e-49 165.7 0.0 7.1e-48 162.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS60095.1 - 1.9e-30 105.5 0.0 8.2e-29 100.2 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain UTP25 PF06862.12 ETS60095.1 - 0.008 15.0 0.4 0.95 8.2 0.0 3.4 3 1 1 4 4 4 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Aminotran_3 PF00202.21 ETS60096.1 - 7.5e-121 403.6 0.0 9.6e-121 403.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ETS60096.1 - 0.0011 18.2 0.0 0.0023 17.2 0.0 1.5 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETS60096.1 - 0.024 13.9 0.0 0.13 11.5 0.0 2.0 1 1 0 1 1 1 0 Beta-eliminating lyase DUF3128 PF11326.8 ETS60097.1 - 1e-23 83.5 1.0 1.4e-23 83.1 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) HGTP_anticodon PF03129.20 ETS60099.1 - 1.2e-20 73.5 0.1 3.9e-20 71.8 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ETS60099.1 - 1.7e-09 37.9 0.1 4.8e-09 36.4 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) zf-C2H2 PF00096.26 ETS60100.1 - 1.6e-19 69.2 29.9 0.00016 21.9 1.8 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETS60100.1 - 5.3e-17 61.4 21.4 7.4e-08 32.5 0.1 5.2 4 1 1 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETS60100.1 - 2.2e-07 31.1 25.8 0.027 15.3 1.5 5.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETS60100.1 - 0.08 13.3 5.4 0.7 10.3 0.0 4.1 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ETS60100.1 - 0.088 13.4 8.6 2.1 9.0 0.0 3.9 4 0 0 4 4 4 0 FOXP coiled-coil domain IGPD PF00475.18 ETS60100.1 - 0.14 12.4 0.5 0.29 11.4 0.1 1.7 2 0 0 2 2 2 0 Imidazoleglycerol-phosphate dehydratase NUDIX PF00293.28 ETS60101.1 - 3e-16 59.6 0.0 4.2e-15 56.0 0.0 2.1 1 1 0 1 1 1 1 NUDIX domain LAT PF15234.6 ETS60101.1 - 0.017 14.9 0.2 0.038 13.7 0.0 1.7 2 0 0 2 2 2 0 Linker for activation of T-cells ATP-synt_10 PF05176.14 ETS60102.1 - 4.1e-53 180.2 0.0 6.2e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 ATP10 protein GFO_IDH_MocA PF01408.22 ETS60103.1 - 9.8e-24 84.5 0.9 1.7e-23 83.7 0.9 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ETS60103.1 - 0.00012 22.7 1.7 0.00018 22.1 1.7 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ETS60103.1 - 0.0024 18.3 0.3 0.0046 17.4 0.3 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ETS60103.1 - 0.018 15.6 0.4 0.045 14.3 0.1 1.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Rossmann-like PF10727.9 ETS60103.1 - 0.045 13.6 0.7 0.081 12.8 0.7 1.4 1 0 0 1 1 1 0 Rossmann-like domain SMP PF04927.12 ETS60103.1 - 1.1 9.8 5.3 0.15 12.5 0.6 2.0 2 0 0 2 2 2 0 Seed maturation protein Redoxin PF08534.10 ETS60104.1 - 1.5e-29 102.6 0.1 1.8e-29 102.3 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ETS60104.1 - 6e-14 52.0 0.0 9.8e-14 51.3 0.0 1.3 1 1 0 1 1 1 1 AhpC/TSA family Fip1 PF05182.13 ETS60105.1 - 2.5e-18 65.3 1.8 6.2e-18 64.0 1.0 2.1 2 0 0 2 2 2 1 Fip1 motif PAS_9 PF13426.7 ETS60106.1 - 8.1e-24 83.9 0.0 1.4e-14 54.2 0.0 2.6 3 0 0 3 3 3 2 PAS domain PAS_3 PF08447.12 ETS60106.1 - 2e-16 60.1 0.0 2.4e-07 30.9 0.0 4.3 3 1 0 3 3 3 3 PAS fold PAS PF00989.25 ETS60106.1 - 6.2e-16 58.4 0.0 4.5e-10 39.5 0.0 4.1 3 1 0 3 3 3 2 PAS fold PAS_4 PF08448.10 ETS60106.1 - 1.4e-07 31.7 0.0 0.00018 21.7 0.0 3.5 3 0 0 3 3 3 1 PAS fold PAS_8 PF13188.7 ETS60106.1 - 1.6e-05 24.8 0.0 0.016 15.2 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_11 PF14598.6 ETS60106.1 - 0.0075 16.4 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 PAS domain SMC_N PF02463.19 ETS60109.1 - 5.8e-72 241.7 5.2 5.2e-71 238.6 5.3 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ETS60109.1 - 1.8e-22 79.8 0.0 5.1e-22 78.4 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ETS60109.1 - 8.3e-09 35.7 16.1 6.5e-05 22.9 1.5 4.3 3 2 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETS60109.1 - 0.00083 19.1 0.0 0.0017 18.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain DivIVA PF05103.13 ETS60109.1 - 0.0036 17.4 5.7 0.0036 17.4 5.7 7.4 6 3 3 9 9 9 2 DivIVA protein AAA_22 PF13401.6 ETS60109.1 - 0.0037 17.5 0.3 27 5.0 0.0 4.2 3 0 0 3 3 3 0 AAA domain DUF724 PF05266.14 ETS60109.1 - 0.0058 16.5 8.2 0.0058 16.5 8.2 7.3 5 2 3 9 9 9 1 Protein of unknown function (DUF724) DUF948 PF06103.11 ETS60109.1 - 3.5 8.0 17.3 5.4 7.3 0.6 5.5 4 1 1 5 5 5 0 Bacterial protein of unknown function (DUF948) KR PF08659.10 ETS60110.1 - 0.063 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 KR domain DEC-1_N PF04625.13 ETS60110.1 - 0.1 11.6 2.1 0.22 10.5 2.1 1.5 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Pkinase PF00069.25 ETS60111.1 - 1.8e-62 211.1 0.0 8.9e-62 208.8 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60111.1 - 9.6e-29 100.4 0.0 8.7e-28 97.3 0.0 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETS60111.1 - 0.00064 18.8 0.1 0.00092 18.2 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ETS60111.1 - 0.0041 16.5 0.0 0.0071 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like HSP90 PF00183.18 ETS60113.1 - 3.3e-225 748.9 25.4 4.3e-225 748.5 25.4 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ETS60113.1 - 4.3e-15 56.2 0.1 8.8e-15 55.2 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETS60113.1 - 7.5e-11 42.0 0.1 2.6e-10 40.3 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 ETS60113.1 - 0.055 13.4 0.1 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Haem-binding uptake, Tiki superfamily, ChaN DUF2052 PF09747.9 ETS60113.1 - 1.7 8.8 14.5 1.2 9.2 9.1 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Peptidase_C37 PF05416.12 ETS60113.1 - 8.5 4.8 9.5 3 6.2 0.1 2.2 2 0 0 2 2 2 0 Southampton virus-type processing peptidase Glyco_hydro_79C PF16862.5 ETS60114.1 - 2.9e-13 50.6 0.0 6.4e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 79 C-terminal beta domain Cellulase PF00150.18 ETS60114.1 - 0.00039 19.9 0.0 0.00057 19.4 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Abhydrolase_3 PF07859.13 ETS60115.1 - 3.3e-36 125.1 0.0 5.3e-36 124.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETS60115.1 - 8.1e-08 32.0 0.0 4.1e-07 29.7 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ETS60115.1 - 0.00016 21.3 0.0 0.0084 15.7 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 ETS60115.1 - 0.0008 19.1 0.1 0.0031 17.2 0.0 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ETS60115.1 - 0.00085 19.2 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase AXE1 PF05448.12 ETS60115.1 - 0.0021 16.8 0.0 0.0037 16.0 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 ETS60115.1 - 0.012 15.6 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Thioesterase PF00975.20 ETS60115.1 - 0.031 14.4 0.0 0.067 13.3 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain DUF2974 PF11187.8 ETS60115.1 - 0.11 12.1 0.1 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) adh_short PF00106.25 ETS60117.1 - 1.6e-33 115.9 0.2 1.9e-33 115.6 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60117.1 - 7.1e-22 78.1 0.2 1.1e-21 77.5 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS60117.1 - 2.5e-09 37.3 0.3 5.2e-09 36.3 0.3 1.4 1 1 0 1 1 1 1 KR domain RNase_P_p30 PF01876.16 ETS60118.1 - 7.6e-59 198.8 0.0 4.1e-58 196.4 0.0 2.0 1 1 0 1 1 1 1 RNase P subunit p30 Erf4 PF10256.9 ETS60119.1 - 2.6e-10 40.4 0.0 4.7e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family DUF4646 PF15496.6 ETS60119.1 - 0.00029 21.5 0.0 0.00054 20.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) Esterase_phd PF10503.9 ETS60120.1 - 8.4e-05 22.2 0.1 0.00015 21.3 0.1 1.4 1 0 0 1 1 1 1 Esterase PHB depolymerase BAAT_C PF08840.11 ETS60120.1 - 0.0035 17.3 0.0 0.0046 16.9 0.0 1.2 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 ETS60120.1 - 0.1 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Putative_PNPOx PF01243.20 ETS60121.1 - 0.0014 18.7 0.0 0.0033 17.6 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Zn_clus PF00172.18 ETS60122.1 - 0.0011 19.1 7.3 0.0032 17.6 7.3 1.9 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RTA1 PF04479.13 ETS60123.1 - 1.4e-37 129.4 1.8 2.3e-37 128.6 1.8 1.4 1 0 0 1 1 1 1 RTA1 like protein FAD_binding_4 PF01565.23 ETS60124.1 - 2.6e-20 72.6 1.4 8.5e-19 67.7 1.4 2.4 1 1 0 1 1 1 1 FAD binding domain BBE PF08031.12 ETS60124.1 - 7.2e-08 32.4 0.0 2.3e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 Berberine and berberine like Aldo_ket_red PF00248.21 ETS60125.1 - 6.9e-61 206.0 0.0 8.4e-61 205.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF1772 PF08592.11 ETS60126.1 - 8.5e-25 87.7 7.7 1.5e-24 86.8 7.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Methyltransf_31 PF13847.6 ETS60127.1 - 2.8e-24 85.6 0.0 8.4e-24 84.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS60127.1 - 1.8e-22 79.9 0.0 1.4e-21 76.9 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS60127.1 - 2e-22 79.6 0.1 6.3e-22 78.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS60127.1 - 8.2e-16 58.6 0.0 1.7e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS60127.1 - 2.1e-13 50.4 0.0 3.2e-13 49.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS60127.1 - 2.6e-13 49.8 0.0 6.5e-13 48.6 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 ETS60127.1 - 5.1e-07 29.7 0.0 7.5e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ETS60127.1 - 5.7e-07 29.2 0.0 1.3e-06 28.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_9 PF08003.11 ETS60127.1 - 4e-05 22.7 0.0 8.5e-05 21.6 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 ETS60127.1 - 6.4e-05 22.6 0.0 0.0038 16.8 0.0 2.2 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW DREV PF05219.12 ETS60127.1 - 0.00056 19.1 0.0 0.0027 16.9 0.0 1.8 1 1 0 1 1 1 1 DREV methyltransferase Methyltransf_8 PF05148.15 ETS60127.1 - 0.00071 19.5 0.0 0.0068 16.3 0.0 2.0 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_4 PF02390.17 ETS60127.1 - 0.00078 19.0 0.0 0.0011 18.5 0.0 1.4 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 ETS60127.1 - 0.002 18.1 0.0 0.0032 17.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 ETS60127.1 - 0.003 17.1 0.0 1 8.8 0.0 2.3 1 1 1 2 2 2 2 CheR methyltransferase, SAM binding domain Pox_MCEL PF03291.16 ETS60127.1 - 0.019 14.1 0.0 0.026 13.7 0.0 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Methyltr_RsmB-F PF01189.17 ETS60127.1 - 0.023 14.3 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F NodS PF05401.11 ETS60127.1 - 0.032 13.8 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) PrmA PF06325.13 ETS60127.1 - 0.095 12.1 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 ETS60127.1 - 0.1 11.6 0.0 0.29 10.1 0.0 1.7 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Lyase_1 PF00206.20 ETS60129.1 - 9.5e-96 320.9 0.0 1.3e-95 320.4 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 ETS60129.1 - 1.2e-24 86.9 0.0 2.6e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Glyco_transf_21 PF13506.6 ETS60130.1 - 1.5e-21 76.6 0.3 1.7e-08 34.1 0.0 3.3 3 0 0 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 ETS60130.1 - 5.7e-10 39.5 0.0 9.1e-08 32.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 KAR9 PF08580.10 ETS60131.1 - 7.5e-19 67.8 11.0 7.5e-19 67.8 11.0 4.1 2 1 1 3 3 3 1 Yeast cortical protein KAR9 GAS2 PF02187.17 ETS60131.1 - 0.001 19.1 0.2 0.0022 18.0 0.2 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Spectrin PF00435.21 ETS60131.1 - 0.4 11.2 5.6 6.4 7.3 0.1 3.8 4 0 0 4 4 4 0 Spectrin repeat ATG16 PF08614.11 ETS60131.1 - 1.9 8.7 10.1 7.2 6.8 0.3 3.9 3 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Ribosomal_L27 PF01016.19 ETS60132.1 - 3.2e-31 107.2 0.1 5.5e-31 106.4 0.1 1.3 1 0 0 1 1 1 1 Ribosomal L27 protein Tim17 PF02466.19 ETS60133.1 - 2.8e-22 79.2 6.6 4.4e-22 78.6 6.6 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Fungal_trans PF04082.18 ETS60134.1 - 3.7e-13 49.1 0.0 5.8e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS60134.1 - 0.00036 20.6 11.3 0.00065 19.8 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PHF5 PF03660.14 ETS60135.1 - 1.5e-49 166.5 6.2 1.7e-49 166.3 6.2 1.0 1 0 0 1 1 1 1 PHF5-like protein C1_2 PF03107.16 ETS60135.1 - 0.023 15.0 11.8 0.61 10.5 2.7 2.3 1 1 1 2 2 2 0 C1 domain PolC_DP2 PF03833.13 ETS60135.1 - 0.1 10.4 3.5 0.11 10.3 3.5 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 ETS60135.1 - 0.15 12.1 9.4 1.5 8.9 1.2 2.3 1 1 1 2 2 2 0 Double zinc ribbon RecR PF02132.15 ETS60135.1 - 0.74 9.4 13.0 0.66 9.6 0.8 3.3 3 0 0 3 3 3 0 RecR protein DUF2039 PF10217.9 ETS60135.1 - 0.93 9.9 8.7 0.77 10.1 1.3 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) zf-C3HC4_3 PF13920.6 ETS60135.1 - 1.6 8.6 13.0 2.9 7.8 4.9 3.2 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C6H2 PF15801.5 ETS60135.1 - 2.2 8.6 7.9 2 8.8 2.0 2.7 2 1 1 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding TF_Zn_Ribbon PF08271.12 ETS60135.1 - 3.8 7.1 12.2 1.2 8.7 1.4 2.7 2 1 0 2 2 2 0 TFIIB zinc-binding Prok-RING_1 PF14446.6 ETS60135.1 - 6.7 6.7 11.4 1.6 8.7 2.1 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 PH_12 PF16457.5 ETS60136.1 - 4.4e-30 104.9 0.0 8.2e-30 104.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain ELMO_CED12 PF04727.13 ETS60136.1 - 8.5e-28 97.7 0.0 1.3e-27 97.1 0.0 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.8 ETS60136.1 - 2.3e-20 73.1 0.0 8.4e-20 71.3 0.0 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3361) HEAT_2 PF13646.6 ETS60136.1 - 0.14 12.6 0.1 27 5.2 0.1 3.7 3 0 0 3 3 3 0 HEAT repeats Coq4 PF05019.13 ETS60137.1 - 3.8e-63 212.8 0.0 2.6e-50 170.8 0.0 2.1 1 1 1 2 2 2 2 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF3377 PF11857.8 ETS60139.1 - 0.026 14.4 0.5 3.3 7.7 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) EphA2_TM PF14575.6 ETS60139.1 - 0.44 11.4 1.3 4 8.4 0.0 3.2 5 0 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain DUF2615 PF11027.8 ETS60139.1 - 2.4 8.3 6.5 4.5 7.5 0.1 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2615) DUF4131 PF13567.6 ETS60139.1 - 9.6 5.8 9.0 60 3.2 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Melibiase_2 PF16499.5 ETS60140.1 - 5.4e-46 157.0 0.0 8.4e-46 156.4 0.0 1.3 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ETS60140.1 - 8.8e-11 41.7 1.9 1.5e-10 41.0 0.5 2.1 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ETS60140.1 - 1.1e-05 24.5 0.0 2.9e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 Melibiase FMN_dh PF01070.18 ETS60141.1 - 4.3e-107 358.2 0.1 9.1e-107 357.1 0.0 1.5 2 0 0 2 2 2 1 FMN-dependent dehydrogenase DUF4646 PF15496.6 ETS60141.1 - 5.7e-37 127.1 0.0 1e-36 126.3 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) IMPDH PF00478.25 ETS60141.1 - 6.7e-05 22.0 0.2 0.00012 21.2 0.2 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 ETS60141.1 - 0.0026 16.9 0.1 0.0044 16.2 0.1 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase SR-25 PF10500.9 ETS60141.1 - 0.0035 17.0 13.8 0.0035 17.0 13.8 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein ThiG PF05690.14 ETS60141.1 - 0.0059 15.9 0.2 1.1 8.5 0.0 2.5 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG Amidase PF01425.21 ETS60142.1 - 1.9e-107 360.0 1.3 7.3e-107 358.1 1.3 1.8 1 1 0 1 1 1 1 Amidase Response_reg PF00072.24 ETS60144.1 - 8.8e-16 58.1 0.0 1.5e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain Tropomyosin_1 PF12718.7 ETS60145.1 - 1.4e-44 151.7 22.9 1.4e-44 151.7 22.9 1.4 2 0 0 2 2 1 1 Tropomyosin like Tropomyosin PF00261.20 ETS60145.1 - 2.4e-09 36.9 22.7 4.4e-06 26.2 9.4 2.4 1 1 1 2 2 2 2 Tropomyosin GAS PF13851.6 ETS60145.1 - 3.1e-05 23.4 19.0 4.9e-05 22.8 19.0 1.3 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 ETS60145.1 - 0.0023 17.3 19.9 0.022 14.1 7.4 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETS60145.1 - 0.0025 17.8 2.7 0.0025 17.8 2.7 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) KLRAQ PF10205.9 ETS60145.1 - 0.015 15.5 1.5 0.015 15.5 1.5 2.7 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein FPP PF05911.11 ETS60145.1 - 0.017 13.3 17.3 0.021 13.0 17.3 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil CtIP_N PF10482.9 ETS60145.1 - 0.037 14.1 14.7 0.26 11.3 12.1 2.2 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain TRAF_BIRC3_bd PF16673.5 ETS60145.1 - 0.04 13.7 0.1 0.04 13.7 0.1 3.2 3 1 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain CENP-F_leu_zip PF10473.9 ETS60145.1 - 0.045 13.8 23.1 0.22 11.5 1.9 3.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETS60145.1 - 0.045 12.6 21.4 0.16 10.8 6.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Csm1_N PF18504.1 ETS60145.1 - 0.15 12.4 22.5 0.058 13.7 5.4 3.6 1 1 2 3 3 3 0 Csm1 N-terminal domain PI3K_P85_iSH2 PF16454.5 ETS60145.1 - 0.15 11.7 16.9 1.4 8.5 6.7 2.3 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FlaC_arch PF05377.11 ETS60145.1 - 0.16 12.4 11.4 4.3 7.8 0.8 4.3 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 ETS60145.1 - 0.26 11.4 21.6 0.33 11.0 8.7 2.8 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4763 PF15960.5 ETS60145.1 - 0.3 10.4 12.6 0.6 9.4 2.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) COG2 PF06148.11 ETS60145.1 - 0.44 10.6 9.5 2 8.5 0.4 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CASP_C PF08172.12 ETS60145.1 - 0.52 9.6 12.0 0.37 10.1 1.0 2.5 1 1 0 2 2 2 0 CASP C terminal KASH_CCD PF14662.6 ETS60145.1 - 0.68 9.7 22.1 24 4.7 22.1 2.1 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Macoilin PF09726.9 ETS60145.1 - 0.77 8.2 13.2 0.98 7.9 13.2 1.3 1 0 0 1 1 1 0 Macoilin family HOOK PF05622.12 ETS60145.1 - 0.84 7.7 19.4 1.2 7.2 19.4 1.1 1 0 0 1 1 1 0 HOOK protein DUF3584 PF12128.8 ETS60145.1 - 0.85 7.1 20.3 8.8 3.7 20.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 ETS60145.1 - 0.89 10.0 21.6 3.3 8.1 21.7 1.8 1 1 0 1 1 1 0 Fez1 TMF_DNA_bd PF12329.8 ETS60145.1 - 0.91 9.6 25.5 2.2 8.3 9.4 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding YlqD PF11068.8 ETS60145.1 - 0.93 9.9 12.2 2.9 8.3 11.6 2.1 1 1 1 2 2 2 0 YlqD protein DUF812 PF05667.11 ETS60145.1 - 1 8.2 21.0 1.8 7.4 9.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Fib_alpha PF08702.10 ETS60145.1 - 1.1 9.5 10.6 3.2 7.9 1.0 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 ETS60145.1 - 1.1 9.6 14.1 0.95 9.8 6.3 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.9 ETS60145.1 - 1.1 9.5 26.3 6.7e+02 0.4 26.3 2.3 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 ETS60145.1 - 1.1 9.4 30.0 1.1 9.4 25.5 2.6 2 1 0 2 2 1 0 Autophagy protein 16 (ATG16) SlyX PF04102.12 ETS60145.1 - 1.2 9.8 12.2 5.2 7.8 2.0 3.7 2 2 1 3 3 2 0 SlyX DHR10 PF18595.1 ETS60145.1 - 1.2 9.2 28.2 1.9 8.6 4.6 3.2 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain Borrelia_P83 PF05262.11 ETS60145.1 - 1.4 7.4 18.2 1.7 7.1 18.2 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF4559 PF15112.6 ETS60145.1 - 1.5 8.4 13.5 2.1 8.0 2.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4559) DUF16 PF01519.16 ETS60145.1 - 1.5 9.3 13.0 7.2 7.1 3.5 2.6 1 1 0 2 2 2 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.12 ETS60145.1 - 1.6 8.8 25.0 25 5.0 25.0 2.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4446 PF14584.6 ETS60145.1 - 1.7 8.6 8.0 2 8.4 1.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) Prominin PF05478.11 ETS60145.1 - 1.8 6.4 6.3 2.3 6.1 6.3 1.1 1 0 0 1 1 1 0 Prominin DUF4201 PF13870.6 ETS60145.1 - 2.2 8.0 17.4 1.1 8.9 6.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) YabA PF06156.13 ETS60145.1 - 2.3 8.9 11.9 15 6.3 1.5 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DUF4200 PF13863.6 ETS60145.1 - 2.3 8.6 20.6 2.6 8.4 6.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) BRE1 PF08647.11 ETS60145.1 - 2.5 8.2 18.0 0.34 11.0 1.2 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF2968 PF11180.8 ETS60145.1 - 2.9 7.5 16.1 4.4 6.9 7.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Laminin_II PF06009.12 ETS60145.1 - 3.4 7.7 12.5 1.3 9.1 3.6 2.3 1 1 1 2 2 2 0 Laminin Domain II PspA_IM30 PF04012.12 ETS60145.1 - 3.6 7.1 23.1 0.81 9.2 4.2 2.8 1 1 1 2 2 2 0 PspA/IM30 family DUF641 PF04859.12 ETS60145.1 - 3.8 7.8 16.6 0.44 10.9 2.3 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 ETS60145.1 - 4 6.4 17.2 1.1 8.2 6.4 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 XhlA PF10779.9 ETS60145.1 - 4.1 7.7 18.6 9.8 6.5 2.3 3.6 1 1 1 3 3 3 0 Haemolysin XhlA bZIP_1 PF00170.21 ETS60145.1 - 4.1 7.6 14.5 2.7 8.1 2.3 3.3 2 1 1 3 3 3 0 bZIP transcription factor DUF919 PF06034.11 ETS60145.1 - 4.1 7.3 7.1 2.8 7.8 0.5 2.7 3 0 0 3 3 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF724 PF05266.14 ETS60145.1 - 4.2 7.2 17.6 6.5 6.5 7.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) NPV_P10 PF05531.12 ETS60145.1 - 4.3 7.9 8.1 4 8.0 1.5 2.9 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF3552 PF12072.8 ETS60145.1 - 4.7 6.6 21.2 4.2 6.7 14.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) CENP-K PF11802.8 ETS60145.1 - 5.4 6.5 14.9 0.25 10.9 4.2 2.2 1 1 1 2 2 2 0 Centromere-associated protein K Fzo_mitofusin PF04799.13 ETS60145.1 - 6.2 6.3 11.7 0.82 9.2 4.6 2.2 1 1 1 2 2 2 0 fzo-like conserved region HIP1_clath_bdg PF16515.5 ETS60145.1 - 6.2 7.5 21.0 5.6 7.6 7.7 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Mgr1 PF08602.10 ETS60145.1 - 6.3 5.5 5.8 4.8 5.9 4.4 1.4 1 1 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit JIP_LZII PF16471.5 ETS60145.1 - 6.5 7.0 16.8 7.5 6.8 1.1 3.1 1 1 1 3 3 3 0 JNK-interacting protein leucine zipper II AAA_13 PF13166.6 ETS60145.1 - 6.6 5.2 15.7 21 3.6 15.7 1.6 1 1 0 1 1 1 0 AAA domain T3SSipB PF16535.5 ETS60145.1 - 6.7 7.2 15.5 56 4.2 15.5 2.1 1 1 0 1 1 1 0 Type III cell invasion protein SipB DUF4407 PF14362.6 ETS60145.1 - 7.8 5.8 18.2 19 4.5 18.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Uds1 PF15456.6 ETS60145.1 - 7.9 6.7 19.7 7.5 6.7 4.6 3.1 1 1 1 2 2 2 0 Up-regulated During Septation ORF6C PF10552.9 ETS60145.1 - 8.6 6.5 7.6 9.3 6.4 3.5 2.2 2 0 0 2 2 2 0 ORF6C domain Spectrin PF00435.21 ETS60145.1 - 8.7 6.9 18.1 2.3 8.8 8.5 3.2 1 1 1 2 2 2 0 Spectrin repeat OmpH PF03938.14 ETS60145.1 - 8.7 6.7 18.6 6.7 7.0 4.4 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) ERM PF00769.19 ETS60145.1 - 8.8 6.1 25.6 25 4.6 25.6 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.19 ETS60145.1 - 9 4.1 10.3 14 3.4 10.0 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family HemX PF04375.14 ETS60145.1 - 9.7 5.4 16.9 4.6 6.4 5.1 2.2 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Kinesin PF00225.23 ETS60146.1 - 1.8e-96 323.0 0.0 1.8e-96 323.0 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETS60146.1 - 4.7e-50 169.4 0.0 1.2e-49 168.1 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding DMPK_coil PF08826.10 ETS60146.1 - 0.039 14.1 0.3 0.039 14.1 0.3 3.9 3 1 1 4 4 4 0 DMPK coiled coil domain like UpxZ PF06603.11 ETS60146.1 - 0.07 13.4 0.0 0.7 10.2 0.0 2.5 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists DASH_Dam1 PF08653.10 ETS60146.1 - 0.14 12.0 0.3 24 4.8 0.0 3.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 Csm1_N PF18504.1 ETS60146.1 - 0.17 12.3 0.2 0.17 12.3 0.2 3.9 1 1 2 4 4 4 0 Csm1 N-terminal domain LPP PF04728.13 ETS60146.1 - 0.32 11.4 8.1 0.17 12.3 0.6 3.5 3 0 0 3 3 3 0 Lipoprotein leucine-zipper FAM76 PF16046.5 ETS60146.1 - 1.4 8.2 16.1 2.7 7.3 16.1 1.4 1 0 0 1 1 1 0 FAM76 protein DUF1664 PF07889.12 ETS60146.1 - 2.7 8.0 9.9 0.21 11.6 2.8 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 ETS60146.1 - 3.9 6.0 18.2 8 5.0 18.2 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETS60146.1 - 8.6 6.7 9.4 0.37 11.1 0.1 3.1 2 2 0 2 2 1 0 AAA ATPase domain TRAUB PF08164.12 ETS60147.1 - 2.7e-26 91.9 0.2 1.8e-24 86.1 0.0 3.2 3 0 0 3 3 3 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 ETS60147.1 - 2.1e-24 86.8 0.3 2.1e-24 86.8 0.3 2.5 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor DNA_pol_phi PF04931.13 ETS60147.1 - 6.2 4.8 40.9 3.5 5.6 24.5 2.2 2 0 0 2 2 2 0 DNA polymerase phi Nsp1_C PF05064.13 ETS60148.1 - 2.2e-31 108.1 0.0 5e-31 106.9 0.0 1.5 2 0 0 2 2 2 1 Nsp1-like C-terminal region Baculo_PEP_C PF04513.12 ETS60148.1 - 0.16 12.0 3.1 0.39 10.7 1.2 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ATG16 PF08614.11 ETS60148.1 - 0.23 11.7 1.2 1.1 9.5 0.1 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 ETS60148.1 - 1.5 9.4 3.7 7.2 7.1 0.4 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region CCDC14 PF15254.6 ETS60149.1 - 0.04 12.6 2.0 0.064 11.9 2.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 LIN37 PF15306.6 ETS60149.1 - 0.064 13.5 7.7 1.1 9.5 1.6 2.8 2 0 0 2 2 2 0 LIN37 DUF4200 PF13863.6 ETS60149.1 - 7.2 7.0 15.2 1.4 9.4 11.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Ribosomal_L2_C PF03947.18 ETS60150.1 - 1.8e-51 173.6 2.1 5.9e-51 171.9 2.1 2.0 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ETS60150.1 - 1.3e-25 89.2 0.4 2.6e-25 88.2 0.4 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain DnaJ PF00226.31 ETS60150.1 - 1.4e-19 69.9 0.1 3.5e-19 68.7 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain NuDC PF16273.5 ETS60150.1 - 0.044 14.3 13.7 0.17 12.4 3.9 3.1 2 0 0 2 2 2 0 Nuclear distribution C domain Glyco_transf_22 PF03901.17 ETS60151.1 - 3.1e-46 158.4 11.3 3.9e-46 158.1 11.3 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family TPR_1 PF00515.28 ETS60153.1 - 1.7e-08 33.9 2.1 0.013 15.3 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETS60153.1 - 1.1e-07 31.4 12.6 0.00083 19.3 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS60153.1 - 1.5e-07 31.4 2.5 0.0011 19.1 0.0 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS60153.1 - 5.6e-06 26.5 1.2 2.8e-05 24.2 1.2 2.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETS60153.1 - 7.4e-06 25.8 1.3 0.17 12.2 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS60153.1 - 1.4e-05 25.1 0.3 0.4 11.2 0.0 4.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS60153.1 - 0.0029 18.2 2.0 0.015 15.9 2.8 7.2 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS60153.1 - 0.0054 17.2 0.4 0.0054 17.2 0.4 6.7 6 1 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETS60153.1 - 0.015 15.0 0.0 5.5 6.8 0.0 3.7 2 1 1 3 3 3 0 TPR repeat CnrY PF17524.2 ETS60153.1 - 0.023 14.9 0.1 0.21 11.8 0.0 2.8 2 0 0 2 2 2 0 Anti-sigma factor CnrY TPR_7 PF13176.6 ETS60153.1 - 0.023 14.7 3.3 24 5.2 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETS60153.1 - 8 6.5 7.7 4.9 7.2 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETS60153.1 - 8.2 6.8 15.6 0.12 12.7 0.3 4.9 6 1 0 6 6 5 0 Tetratricopeptide repeat DUF3835 PF12927.7 ETS60154.1 - 1.8 9.5 17.7 0.078 13.8 1.0 4.9 4 0 0 4 4 4 0 Domain of unknown function (DUF3835) Cupin_8 PF13621.6 ETS60156.1 - 9.8e-07 28.7 0.1 1.1e-05 25.3 0.1 2.4 1 1 1 2 2 2 1 Cupin-like domain JmjC PF02373.22 ETS60156.1 - 1.3e-05 25.6 0.2 0.00087 19.7 0.2 2.7 1 1 0 1 1 1 1 JmjC domain, hydroxylase JHD PF17811.1 ETS60156.1 - 0.00012 22.5 0.0 0.00029 21.3 0.0 1.6 1 0 0 1 1 1 1 Jumonji helical domain PHD PF00628.29 ETS60156.1 - 0.0002 21.2 14.7 0.00052 19.8 14.7 1.8 1 1 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETS60156.1 - 0.18 11.4 14.6 0.035 13.7 10.6 1.9 2 0 0 2 2 2 0 PHD-finger Ammonium_transp PF00909.21 ETS60157.1 - 1.4e-104 349.9 27.0 1.7e-104 349.7 27.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family SepZ PF06066.11 ETS60157.1 - 0.29 11.3 2.8 0.34 11.2 0.5 2.2 2 1 1 3 3 3 0 SepZ DUF2015 PF09435.10 ETS60158.1 - 2.4e-23 82.1 0.0 3.8e-23 81.5 0.0 1.2 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DNA_pol_B PF00136.21 ETS60159.1 - 4.5e-117 391.6 0.0 5.7e-117 391.2 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 ETS60159.1 - 1.6e-58 197.5 1.1 2.9e-58 196.7 1.1 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 ETS60159.1 - 2.1e-29 102.8 0.0 3.4e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 ETS60159.1 - 3e-20 72.0 5.4 3e-20 72.0 5.4 3.1 4 0 0 4 4 4 1 DNA polymerase alpha subunit p180 N terminal VWA_N2 PF16164.5 ETS60159.1 - 0.019 15.1 0.1 0.058 13.5 0.1 1.8 1 0 0 1 1 1 0 VWA N-terminal Sigma70_ner PF04546.13 ETS60159.1 - 2.5 7.9 6.5 50 3.7 0.0 2.8 2 0 0 2 2 2 0 Sigma-70, non-essential region Mito_carr PF00153.27 ETS60160.1 - 1.7e-29 101.5 3.9 2.4e-15 56.2 0.2 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein PRKCSH PF07915.13 ETS60161.1 - 2.9e-13 50.6 0.8 1.4e-08 35.6 0.0 3.2 3 0 0 3 3 3 2 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 ETS60161.1 - 0.041 13.6 0.0 0.08 12.6 0.0 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like protein FXR_C1 PF16096.5 ETS60161.1 - 0.25 11.6 4.0 0.69 10.2 2.0 2.9 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 PX PF00787.24 ETS60162.1 - 8.9e-21 74.0 0.0 2.3e-20 72.7 0.0 1.7 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 ETS60162.1 - 0.00061 19.4 6.8 0.0075 15.8 0.7 2.2 2 0 0 2 2 2 2 Vps5 C terminal like DUF1373 PF07117.11 ETS60162.1 - 0.0082 16.2 3.4 0.0082 16.2 3.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1373) OmpH PF03938.14 ETS60162.1 - 8.4 6.7 8.3 4.9 7.5 0.2 3.0 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) FAD_binding_4 PF01565.23 ETS60163.1 - 2.1e-21 76.1 0.5 3.3e-21 75.5 0.5 1.3 1 0 0 1 1 1 1 FAD binding domain Exo5 PF09810.9 ETS60165.1 - 2.2e-40 139.3 0.0 1.9e-37 129.7 0.0 2.8 1 1 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease GPI2 PF06432.11 ETS60166.1 - 5.6e-46 157.2 6.7 7.6e-46 156.8 6.7 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase MPP6 PF10175.9 ETS60166.1 - 2.3e-06 28.1 0.0 3e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 M-phase phosphoprotein 6 MFS_1 PF07690.16 ETS60168.1 - 2.1e-28 99.3 26.0 8.2e-28 97.3 26.1 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily NAD_kinase PF01513.21 ETS60169.1 - 3e-56 190.8 0.1 4.1e-56 190.3 0.1 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ETS60169.1 - 0.022 14.4 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Ccdc124 PF06244.12 ETS60170.1 - 2.3e-26 92.9 13.0 2.3e-26 92.9 13.0 2.3 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 Rhodanese PF00581.20 ETS60171.1 - 2.6e-16 60.1 0.0 3.5e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain UQ_con PF00179.26 ETS60172.1 - 3e-46 156.6 0.0 3.9e-46 156.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETS60172.1 - 0.0058 16.3 0.0 0.0082 15.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B Pkinase PF00069.25 ETS60173.1 - 4.7e-51 173.7 0.4 7.9e-51 172.9 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60173.1 - 9.5e-22 77.5 0.0 1.5e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 ETS60173.1 - 0.014 14.4 0.1 0.023 13.7 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 ETS60173.1 - 0.064 12.6 0.2 0.11 11.8 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETS60173.1 - 0.076 12.6 0.2 0.25 10.9 0.2 1.8 1 1 0 1 1 1 0 RIO1 family DASH_Duo1 PF08651.10 ETS60174.1 - 0.017 14.9 1.4 6 6.7 0.1 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 CLASP_N PF12348.8 ETS60175.1 - 1.8e-77 259.9 1.8 7.5e-65 218.7 0.0 3.4 3 0 0 3 3 3 3 CLASP N terminal HEAT PF02985.22 ETS60175.1 - 3.2e-05 23.8 1.3 9.6 6.8 0.0 5.0 5 0 0 5 5 5 3 HEAT repeat Dopey_N PF04118.14 ETS60175.1 - 0.0046 16.1 0.0 0.0084 15.3 0.0 1.4 1 0 0 1 1 1 1 Dopey, N-terminal IFRD PF05004.13 ETS60175.1 - 0.41 9.7 6.5 1.6 7.8 0.0 3.4 4 1 0 4 4 4 0 Interferon-related developmental regulator (IFRD) UPF0029 PF01205.19 ETS60176.1 - 2.3e-20 72.9 1.2 1.2e-19 70.5 0.0 2.9 3 1 0 3 3 3 1 Uncharacterized protein family UPF0029 SOG2 PF10428.9 ETS60176.1 - 1.3 8.2 37.1 0.029 13.6 13.5 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein RPN7 PF10602.9 ETS60177.1 - 8.8e-48 162.3 0.0 1.4e-47 161.6 0.0 1.3 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ETS60177.1 - 1.3e-10 41.8 0.0 5.4e-10 39.7 0.0 2.1 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 ETS60177.1 - 0.0023 17.9 0.8 0.43 10.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat CENP-F_N PF10481.9 ETS60177.1 - 0.015 14.9 0.6 0.024 14.3 0.6 1.2 1 0 0 1 1 1 0 Cenp-F N-terminal domain TPR_7 PF13176.6 ETS60177.1 - 0.045 13.8 0.1 3.3 7.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ATHILA PF03078.15 ETS60177.1 - 0.13 11.1 0.3 0.17 10.7 0.3 1.1 1 0 0 1 1 1 0 ATHILA ORF-1 family TPR_16 PF13432.6 ETS60177.1 - 0.17 12.6 2.6 23 5.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RNase_PH PF01138.21 ETS60178.1 - 4.3e-32 111.4 0.8 8.7e-32 110.4 0.0 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 MS_channel PF00924.18 ETS60179.1 - 1.4e-19 70.5 0.4 2e-19 69.9 0.4 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_6 PF13405.6 ETS60179.1 - 0.00042 20.0 0.1 0.0011 18.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 ETS60179.1 - 0.00043 19.6 0.1 0.0009 18.6 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ETS60179.1 - 0.0037 16.7 0.2 0.0075 15.7 0.2 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 ETS60179.1 - 0.0057 16.5 0.1 0.012 15.5 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair Cyclin_N PF00134.23 ETS60180.1 - 6e-08 32.5 0.0 9.6e-06 25.4 0.0 2.9 3 0 0 3 3 3 1 Cyclin, N-terminal domain TFIIB PF00382.19 ETS60180.1 - 0.00021 21.3 0.0 3.1 7.9 0.0 3.5 2 1 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C PF02984.19 ETS60180.1 - 0.08 13.0 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 Cyclin, C-terminal domain Bax1-I PF01027.20 ETS60181.1 - 4.8e-35 121.3 8.9 6.9e-35 120.8 8.9 1.2 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 GspH PF12019.8 ETS60181.1 - 0.049 14.1 2.3 0.099 13.1 2.3 1.5 1 0 0 1 1 1 0 Type II transport protein GspH HEAT_EZ PF13513.6 ETS60182.1 - 1.1e-29 102.5 12.1 1.9e-06 28.2 0.0 10.9 10 0 0 10 10 10 5 HEAT-like repeat HEAT PF02985.22 ETS60182.1 - 6.8e-20 69.5 18.0 0.0059 16.8 0.1 11.9 13 0 0 13 13 11 4 HEAT repeat HEAT_2 PF13646.6 ETS60182.1 - 1.7e-18 66.8 13.7 2.5e-05 24.6 0.1 8.5 5 4 2 8 8 8 4 HEAT repeats UME PF08064.13 ETS60182.1 - 2.1e-13 50.0 1.9 0.019 14.9 0.0 6.9 7 1 1 8 8 7 3 UME (NUC010) domain Cnd1 PF12717.7 ETS60182.1 - 1.2e-12 48.1 1.7 0.0077 16.3 0.0 5.6 5 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 ETS60182.1 - 2.5e-09 36.8 1.2 0.043 12.9 0.0 6.4 4 2 1 7 7 7 1 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 ETS60182.1 - 9.9e-09 35.7 0.0 0.046 14.3 0.0 5.3 6 0 0 6 6 5 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ETS60182.1 - 1.2e-07 30.7 3.7 0.15 10.5 0.1 4.7 5 1 0 5 5 5 3 Adaptin N terminal region IBN_N PF03810.19 ETS60182.1 - 1.2e-07 31.5 0.5 6.7e-07 29.1 0.0 2.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain CLASP_N PF12348.8 ETS60182.1 - 1.7e-05 24.5 0.0 0.33 10.5 0.0 4.7 4 1 0 4 4 4 2 CLASP N terminal IFRD PF05004.13 ETS60182.1 - 2.7e-05 23.4 0.9 0.14 11.2 0.0 3.8 2 1 0 3 3 3 1 Interferon-related developmental regulator (IFRD) Xpo1 PF08389.12 ETS60182.1 - 3.3e-05 24.0 7.2 0.0096 16.0 0.3 5.6 5 1 0 5 5 5 1 Exportin 1-like protein MMS19_N PF14500.6 ETS60182.1 - 0.00016 21.4 1.3 0.35 10.4 0.1 5.0 5 1 0 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II DUF3385 PF11865.8 ETS60182.1 - 0.0014 18.5 6.6 52 3.7 0.0 7.4 8 2 0 8 8 8 0 Domain of unknown function (DUF3385) RIX1 PF08167.12 ETS60182.1 - 0.002 17.9 0.1 3.9 7.2 0.0 4.8 5 1 0 5 5 5 1 rRNA processing/ribosome biogenesis Cohesin_HEAT PF12765.7 ETS60182.1 - 0.0058 16.9 0.9 1.2 9.5 0.1 3.5 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion Ipi1_N PF12333.8 ETS60182.1 - 0.0072 16.9 0.0 23 5.7 0.0 4.7 4 1 1 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation DUF3437 PF11919.8 ETS60182.1 - 0.0083 16.0 2.9 0.98 9.4 0.1 5.3 6 1 1 7 7 7 1 Domain of unknown function (DUF3437) CAS_CSE1 PF03378.15 ETS60182.1 - 0.0094 14.5 0.2 2.5 6.5 0.0 3.9 5 0 0 5 5 5 1 CAS/CSE protein, C-terminus RTP1_C1 PF10363.9 ETS60182.1 - 0.035 14.3 0.4 80 3.5 0.0 4.7 5 0 0 5 5 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Dopey_N PF04118.14 ETS60182.1 - 0.053 12.6 0.3 12 4.9 0.0 2.8 2 1 0 2 2 2 0 Dopey, N-terminal Cnd3 PF12719.7 ETS60182.1 - 0.11 11.6 7.1 2.8 7.1 0.4 5.1 3 3 2 5 5 5 0 Nuclear condensing complex subunits, C-term domain Arm PF00514.23 ETS60182.1 - 1.1 9.4 13.3 29 4.9 0.1 7.7 10 0 0 10 10 9 0 Armadillo/beta-catenin-like repeat Myosin_head PF00063.21 ETS60183.1 - 2.2e-263 875.5 0.0 3.3e-263 874.9 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 ETS60183.1 - 2.3e-27 95.3 0.9 2.3e-27 95.3 0.9 2.8 4 0 0 4 4 2 1 DIL domain IQ PF00612.27 ETS60183.1 - 5.6e-18 63.0 32.4 5.3e-05 22.7 0.2 6.8 6 0 0 6 6 6 6 IQ calmodulin-binding motif AAA_22 PF13401.6 ETS60183.1 - 0.0067 16.7 0.0 0.024 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain CALCOCO1 PF07888.11 ETS60183.1 - 0.0074 15.2 20.1 0.013 14.4 20.1 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like AAA_16 PF13191.6 ETS60183.1 - 0.07 13.5 1.9 0.65 10.4 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain DUF1515 PF07439.11 ETS60183.1 - 0.12 12.4 0.9 0.97 9.5 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF1192 PF06698.11 ETS60183.1 - 0.42 10.7 12.3 0.19 11.8 5.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Myosin_N PF02736.19 ETS60183.1 - 0.52 10.2 2.2 1.5 8.8 0.2 2.3 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain ATG16 PF08614.11 ETS60183.1 - 0.65 10.2 22.0 3.2 7.9 5.4 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) FAM76 PF16046.5 ETS60183.1 - 2.5 7.4 11.9 5.5 6.3 11.9 1.6 1 0 0 1 1 1 0 FAM76 protein BST2 PF16716.5 ETS60183.1 - 7.9 7.1 16.0 15 6.3 2.4 3.9 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 ubiquitin PF00240.23 ETS60184.1 - 4.7e-19 67.9 2.6 1.4e-12 47.2 0.1 2.4 1 1 1 2 2 2 2 Ubiquitin family zf-AN1 PF01428.16 ETS60184.1 - 9.1e-11 41.7 4.9 1.5e-10 41.1 4.9 1.4 1 0 0 1 1 1 1 AN1-like Zinc finger Rad60-SLD PF11976.8 ETS60184.1 - 1e-07 31.7 0.4 0.00017 21.3 0.0 2.4 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 ETS60184.1 - 0.017 15.2 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SMC_Nse1 PF07574.13 ETS60185.1 - 2.8e-27 95.9 3.5 2.7e-26 92.7 3.5 2.1 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 ETS60185.1 - 3.6e-06 27.2 5.2 8.5e-06 26.0 5.2 1.7 1 1 0 1 1 1 1 RING-like domain zf-HC5HC2H PF13771.6 ETS60185.1 - 0.00075 19.7 1.7 0.0016 18.7 1.7 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ETS60185.1 - 0.00079 19.6 0.2 0.0022 18.2 0.2 1.7 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-ANAPC11 PF12861.7 ETS60185.1 - 1.3 9.1 4.4 3.7 7.7 4.4 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_9 PF13901.6 ETS60185.1 - 1.7 8.6 11.0 3.5 7.5 6.5 2.8 1 1 2 3 3 3 0 Putative zinc-RING and/or ribbon Herpes_DNAp_acc PF04929.12 ETS60185.1 - 4.5 6.1 6.5 6.8 5.6 6.5 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Sugar_tr PF00083.24 ETS60186.1 - 2.6e-89 300.2 18.9 3.2e-89 299.9 18.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS60186.1 - 7.9e-18 64.5 44.7 5.8e-17 61.6 17.7 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ETS60186.1 - 0.019 13.3 10.8 0.056 11.7 0.3 3.0 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3792 PF12670.7 ETS60186.1 - 3.5 7.8 20.3 3.1 8.0 2.4 3.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3792) Aminotran_1_2 PF00155.21 ETS60188.1 - 1.2e-86 291.2 0.0 1.5e-86 290.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II PfkB PF00294.24 ETS60189.1 - 1.8e-35 122.7 0.4 2.3e-35 122.4 0.4 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase MSA-2c PF12238.8 ETS60191.1 - 0.085 12.9 3.3 0.13 12.3 3.3 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c GAF_2 PF13185.6 ETS60191.1 - 0.093 13.0 0.1 0.093 13.0 0.1 1.5 2 0 0 2 2 2 0 GAF domain efThoc1 PF11957.8 ETS60192.1 - 8.1e-95 318.3 0.1 1.8e-82 277.6 0.0 3.3 2 1 0 2 2 2 2 THO complex subunit 1 transcription elongation factor Usp PF00582.26 ETS60192.1 - 0.29 11.6 2.1 1.3 9.5 2.1 2.1 1 0 0 1 1 1 0 Universal stress protein family RPN7 PF10602.9 ETS60193.1 - 1.6e-52 177.7 1.2 3e-52 176.8 1.2 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ETS60193.1 - 2.1e-15 57.1 0.1 7e-15 55.4 0.0 2.0 2 0 0 2 2 2 1 PCI domain RRM_1 PF00076.22 ETS60193.1 - 7e-14 51.4 0.0 1.4e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_23 PF13476.6 ETS60193.1 - 0.029 14.9 2.2 0.051 14.1 2.2 1.4 1 0 0 1 1 1 0 AAA domain DUF3035 PF11233.8 ETS60193.1 - 0.069 13.4 1.1 0.17 12.1 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3035) RRM_3 PF08777.11 ETS60193.1 - 0.14 12.2 0.1 0.14 12.2 0.1 2.2 2 0 0 2 2 2 0 RNA binding motif Pribosyltran PF00156.27 ETS60194.1 - 1.1e-15 57.5 0.1 1.4e-15 57.1 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ETS60194.1 - 0.0013 18.2 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase SHR3_chaperone PF08229.11 ETS60197.1 - 4e-46 156.4 0.0 4.7e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 SecG PF03840.14 ETS60197.1 - 0.039 14.0 0.1 0.099 12.7 0.1 1.7 1 0 0 1 1 1 0 Preprotein translocase SecG subunit MgtC PF02308.16 ETS60197.1 - 0.047 14.1 1.6 0.27 11.6 0.6 2.1 2 0 0 2 2 2 0 MgtC family Cmyb_C PF09316.10 ETS60197.1 - 0.077 12.7 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 C-myb, C-terminal UQ_con PF00179.26 ETS60198.1 - 5.2e-20 71.5 0.0 8.8e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETS60198.1 - 0.1 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 RWD domain DnaJ PF00226.31 ETS60199.1 - 2.4e-22 78.8 0.1 3.8e-22 78.2 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain TP2 PF01254.18 ETS60200.1 - 0.048 14.3 4.6 0.037 14.6 3.3 1.5 1 1 1 2 2 2 0 Nuclear transition protein 2 Borrelia_P83 PF05262.11 ETS60200.1 - 7.4 4.9 16.8 8.5 4.7 16.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein OPT PF03169.15 ETS60201.1 - 1.1e-144 483.5 35.1 1.2e-144 483.3 35.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PrgI PF12666.7 ETS60201.1 - 0.21 12.3 0.0 0.21 12.3 0.0 4.9 4 1 0 5 5 5 0 PrgI family protein DUF1453 PF07301.11 ETS60201.1 - 0.21 11.6 3.1 0.39 10.7 0.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1453) VIT1 PF01988.19 ETS60201.1 - 6.1 6.7 6.1 1 9.2 0.1 2.6 3 0 0 3 3 3 0 VIT family Gar1 PF04410.14 ETS60202.1 - 1.2e-36 125.8 0.0 1.5e-36 125.5 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region zf-HIT PF04438.16 ETS60203.1 - 9e-10 38.3 11.8 1.5e-09 37.6 11.8 1.4 1 0 0 1 1 1 1 HIT zinc finger TP6A_N PF04406.14 ETS60203.1 - 0.14 12.2 0.4 0.34 10.9 0.1 1.8 2 0 0 2 2 2 0 Type IIB DNA topoisomerase EF-1_beta_acid PF10587.9 ETS60203.1 - 0.82 10.2 4.8 1.9 9.0 4.8 1.6 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region zf-B_box PF00643.24 ETS60203.1 - 8.5 6.6 9.2 15 5.8 9.2 1.3 1 0 0 1 1 1 0 B-box zinc finger An_peroxidase PF03098.15 ETS60204.1 - 2.6e-42 145.1 0.0 3.2e-25 88.7 0.0 3.4 1 1 2 3 3 3 3 Animal haem peroxidase p450 PF00067.22 ETS60204.1 - 0.022 13.5 0.0 0.039 12.7 0.0 1.4 1 0 0 1 1 1 0 Cytochrome P450 T2SSM_b PF10741.9 ETS60204.1 - 0.045 13.5 3.0 0.096 12.5 3.0 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M subtype b SSF PF00474.17 ETS60205.1 - 1.1e-21 77.3 32.4 1.5e-21 76.7 32.4 1.2 1 0 0 1 1 1 1 Sodium:solute symporter family SdpI PF13630.6 ETS60205.1 - 0.064 13.4 0.5 0.064 13.4 0.5 6.6 7 4 0 7 7 7 0 SdpI/YhfL protein family Peptidase_C97 PF05903.14 ETS60206.1 - 1.5e-36 125.5 0.0 2.6e-36 124.7 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 ETS60206.1 - 4.4e-31 108.2 4.1 6.9e-31 107.5 4.1 1.3 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.20 ETS60206.1 - 3.8e-08 33.2 0.0 9.6e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 ETS60206.1 - 0.00056 19.3 0.0 0.0009 18.7 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ETS60206.1 - 0.037 14.5 0.0 0.096 13.1 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin-like domain PITH PF06201.13 ETS60207.1 - 1.2e-31 110.0 0.0 2.1e-31 109.2 0.0 1.5 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 ETS60207.1 - 1.9e-19 69.5 0.1 6.1e-19 67.9 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ETS60207.1 - 0.00037 20.9 0.2 0.056 13.9 0.0 2.6 1 1 1 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ETS60207.1 - 0.03 14.6 0.1 5 7.5 0.1 2.6 1 1 1 2 2 2 0 Thioredoxin-like Thioredoxin_7 PF13899.6 ETS60207.1 - 0.05 13.8 0.4 0.26 11.5 0.4 2.2 1 1 0 1 1 1 0 Thioredoxin-like HyaE PF07449.11 ETS60207.1 - 0.065 13.2 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE MPS2 PF17060.5 ETS60207.1 - 0.56 9.4 4.2 1.1 8.5 4.2 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 TSC22 PF01166.18 ETS60207.1 - 6.6 7.1 8.5 23 5.4 1.1 2.8 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF202 PF02656.15 ETS60208.1 - 3.5e-10 40.2 0.3 3.5e-10 40.2 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Jiraiya PF15038.6 ETS60208.1 - 0.025 14.0 0.1 0.041 13.3 0.1 1.3 1 0 0 1 1 1 0 Jiraiya P19Arf_N PF07392.12 ETS60208.1 - 4.8 7.7 8.5 1.1 9.8 4.2 2.2 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus HLH PF00010.26 ETS60210.1 - 1e-07 31.8 0.1 1e-07 31.8 0.1 2.0 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF3135 PF11333.8 ETS60210.1 - 0.039 14.2 0.5 0.09 13.0 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3135) RhoGAP PF00620.27 ETS60211.1 - 7.5e-46 155.7 0.0 1.3e-45 154.9 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 ETS60211.1 - 1.1e-14 54.5 0.4 5.2e-14 52.3 0.1 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Pkinase PF00069.25 ETS60212.1 - 5.1e-73 245.7 0.0 6.7e-73 245.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60212.1 - 3.6e-47 160.8 0.0 5e-47 160.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ETS60212.1 - 2.1e-23 82.4 0.0 4.9e-23 81.2 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ETS60212.1 - 1.4e-06 27.3 0.0 2.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETS60212.1 - 3.1e-05 23.5 0.0 6.7e-05 22.3 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETS60212.1 - 0.011 15.1 0.4 0.17 11.2 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETS60212.1 - 0.02 14.8 0.2 0.28 11.1 0.3 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family DSHCT PF08148.12 ETS60212.1 - 0.021 14.5 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 DSHCT (NUC185) domain Rad9 PF04139.13 ETS60213.1 - 2.4e-51 174.6 0.0 2.9e-51 174.4 0.0 1.0 1 0 0 1 1 1 1 Rad9 RINGv PF12906.7 ETS60214.1 - 1.7e-14 53.6 10.2 3.2e-14 52.8 10.2 1.5 1 0 0 1 1 1 1 RING-variant domain PsaL PF02605.15 ETS60214.1 - 0.037 13.7 0.1 0.23 11.1 0.0 2.2 1 1 1 2 2 2 0 Photosystem I reaction centre subunit XI zf-RING_2 PF13639.6 ETS60214.1 - 0.45 10.9 11.8 0.87 10.0 11.8 1.5 1 0 0 1 1 1 0 Ring finger domain zf-ANAPC11 PF12861.7 ETS60214.1 - 5.3 7.2 6.7 14 5.8 6.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger DEAD PF00270.29 ETS60215.1 - 6e-44 149.9 0.0 3.8e-43 147.3 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS60215.1 - 6.9e-27 94.0 0.0 7.4e-26 90.7 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS60215.1 - 5e-05 23.4 0.0 0.00015 21.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit zf-CCHC PF00098.23 ETS60215.1 - 0.0089 16.1 1.1 0.015 15.3 1.1 1.4 1 0 0 1 1 1 1 Zinc knuckle ERCC3_RAD25_C PF16203.5 ETS60215.1 - 0.01 15.1 0.1 0.022 14.0 0.1 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase zf-CCHC_4 PF14392.6 ETS60215.1 - 0.046 13.5 0.3 0.096 12.4 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_2 PF13696.6 ETS60215.1 - 0.082 12.7 2.5 0.19 11.5 2.5 1.6 1 0 0 1 1 1 0 Zinc knuckle Phage_endo_I PF05367.11 ETS60215.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.6 1 0 0 1 1 1 0 Phage endonuclease I Med4 PF10018.9 ETS60216.1 - 8.3e-21 74.5 4.4 1.3e-20 73.9 4.4 1.3 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 CDP-OH_P_transf PF01066.21 ETS60218.1 - 2.6e-13 50.6 0.2 6.5e-13 49.2 0.2 1.7 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase UCH_1 PF13423.6 ETS60219.1 - 1e-91 307.9 0.0 1.4e-91 307.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 ETS60219.1 - 2.1e-19 70.7 0.0 3.8e-18 66.6 0.0 2.3 2 0 0 2 2 2 1 Exonuclease WD40 PF00400.32 ETS60219.1 - 0.0027 18.5 0.1 0.07 14.0 0.0 3.2 2 0 0 2 2 2 1 WD domain, G-beta repeat UCH PF00443.29 ETS60219.1 - 0.043 13.3 0.0 0.41 10.1 0.0 2.2 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PPP4R2 PF09184.11 ETS60219.1 - 0.31 10.6 11.3 0.6 9.6 11.3 1.4 1 0 0 1 1 1 0 PPP4R2 DUF4647 PF15504.6 ETS60219.1 - 5 6.1 8.4 7.6 5.5 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Zn_clus PF00172.18 ETS60221.1 - 2.4e-06 27.5 8.7 5e-06 26.5 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS60221.1 - 0.01 14.9 0.0 0.024 13.7 0.0 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain Q_salvage PF10343.9 ETS60222.1 - 3.1e-08 33.5 0.0 1.4e-05 24.8 0.0 2.2 2 0 0 2 2 2 2 Potential Queuosine, Q, salvage protein family Mitoc_mL59 PF18126.1 ETS60223.1 - 1.2e-28 99.9 2.1 1.7e-28 99.5 2.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 DUF3446 PF11928.8 ETS60223.1 - 0.012 15.9 12.9 0.012 15.9 12.9 1.8 2 0 0 2 2 2 0 Early growth response N-terminal domain Tim44 PF04280.15 ETS60224.1 - 1.6e-32 112.7 0.5 3.5e-32 111.5 0.0 1.9 2 0 0 2 2 2 1 Tim44-like domain SAC3_GANP PF03399.16 ETS60225.1 - 3.5e-22 79.1 4.0 4.1e-20 72.3 4.0 2.5 1 1 0 1 1 1 1 SAC3/GANP family BAG PF02179.16 ETS60225.1 - 7.3e-16 58.4 2.7 2.5e-15 56.7 2.7 2.0 1 0 0 1 1 1 1 BAG domain ubiquitin PF00240.23 ETS60225.1 - 4.8e-05 23.0 0.0 0.00014 21.5 0.0 1.8 1 0 0 1 1 1 1 Ubiquitin family CSN8_PSD8_EIF3K PF10075.9 ETS60225.1 - 0.00031 20.8 0.9 0.0026 17.7 0.2 2.3 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family COX5A PF02284.16 ETS60225.1 - 0.0089 16.0 0.0 0.034 14.1 0.0 2.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va SAGA-Tad1 PF12767.7 ETS60225.1 - 0.063 13.0 5.2 0.12 12.1 0.9 2.4 2 1 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit DUF982 PF06169.12 ETS60225.1 - 0.093 12.8 1.3 16 5.6 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF982) TarH PF02203.15 ETS60225.1 - 1.5 8.7 7.6 0.17 11.8 0.5 2.9 3 0 0 3 3 3 0 Tar ligand binding domain homologue GHMP_kinases_N PF00288.26 ETS60226.1 - 1.9e-10 40.8 0.1 4.8e-10 39.5 0.1 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ETS60226.1 - 0.00044 20.6 0.0 0.0013 19.1 0.0 1.8 1 1 0 1 1 1 1 GHMP kinases C terminal PRP38 PF03371.15 ETS60227.1 - 2e-52 177.6 0.0 2.5e-52 177.3 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Ctr PF04145.15 ETS60228.1 - 0.00016 22.3 13.6 0.05 14.2 7.0 2.3 1 1 1 2 2 2 2 Ctr copper transporter family DUF2070 PF09843.9 ETS60228.1 - 0.079 11.2 1.8 0.085 11.1 1.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) AA_permease PF00324.21 ETS60230.1 - 2.5e-65 220.9 30.3 3.1e-65 220.6 30.3 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 ETS60230.1 - 2.7e-19 69.5 0.3 5.6e-11 42.1 0.0 3.5 3 0 0 3 3 3 3 Solute carrier family 12 Cwf_Cwc_15 PF04889.12 ETS60230.1 - 1.2 8.9 7.2 0.69 9.6 2.3 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Actin PF00022.19 ETS60231.1 - 3.6e-21 75.3 0.0 9.7e-12 44.2 0.0 3.2 3 0 0 3 3 3 3 Actin Actin_micro PF17003.5 ETS60231.1 - 1.8e-05 24.1 0.0 0.054 12.7 0.0 2.3 2 0 0 2 2 2 2 Putative actin-like family TPR_19 PF14559.6 ETS60231.1 - 0.0019 18.6 11.0 0.011 16.2 2.3 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.8 ETS60231.1 - 0.022 13.7 0.0 0.044 12.7 0.0 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 TPR_14 PF13428.6 ETS60231.1 - 0.3 12.0 16.5 0.24 12.3 0.6 5.5 3 1 1 4 4 4 0 Tetratricopeptide repeat Clat_adaptor_s PF01217.20 ETS60232.1 - 9e-56 187.8 2.6 9.9e-56 187.6 2.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PCAF_N PF06466.11 ETS60232.1 - 0.067 12.8 0.1 0.09 12.3 0.1 1.2 1 0 0 1 1 1 0 PCAF (P300/CBP-associated factor) N-terminal domain TPR_2 PF07719.17 ETS60233.1 - 6.7e-07 29.0 3.6 0.0041 17.1 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETS60233.1 - 1.1e-05 25.1 2.6 0.018 14.8 0.1 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETS60233.1 - 0.00024 21.6 1.6 0.041 14.7 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETS60233.1 - 0.0013 18.8 0.5 0.075 13.2 0.0 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETS60233.1 - 0.0029 17.7 0.1 0.073 13.3 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETS60233.1 - 0.02 15.6 1.6 1.3 9.8 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETS60233.1 - 0.048 13.9 0.6 0.77 10.1 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat NADH-u_ox-rdase PF10785.9 ETS60234.1 - 3.7e-32 110.8 0.2 6.4e-32 110.1 0.2 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 ETS60234.1 - 3.5e-12 46.1 0.0 5.1e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit PseudoU_synth_1 PF01416.20 ETS60235.1 - 2.5e-23 82.6 0.0 2.3e-19 69.8 0.0 3.4 3 0 0 3 3 3 2 tRNA pseudouridine synthase DUF1771 PF08590.10 ETS60236.1 - 2.5e-13 50.2 6.3 2.5e-13 50.2 6.3 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) zf-CCCH PF00642.24 ETS60236.1 - 2.2e-05 24.2 11.5 0.0035 17.2 1.7 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS60236.1 - 0.0063 16.5 11.5 0.55 10.4 2.0 3.1 2 2 0 2 2 2 2 Zinc finger domain HBS1_N PF08938.10 ETS60236.1 - 0.0082 16.4 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 HBS1 N-terminus zf-CCCH_3 PF15663.5 ETS60236.1 - 0.014 15.6 6.6 0.081 13.1 6.6 2.0 1 1 0 1 1 1 0 Zinc-finger containing family zf-CCCH_4 PF18044.1 ETS60236.1 - 0.018 14.8 18.4 0.033 14.0 4.8 3.1 2 2 0 2 2 2 0 CCCH-type zinc finger Smr PF01713.21 ETS60236.1 - 0.073 13.4 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 Smr domain CD225 PF04505.12 ETS60236.1 - 0.16 12.1 1.0 0.56 10.4 1.0 1.9 1 0 0 1 1 1 0 Interferon-induced transmembrane protein LUC7 PF03194.15 ETS60236.1 - 1.4 8.5 4.4 0.47 10.1 0.1 2.2 2 1 1 3 3 3 0 LUC7 N_terminus Torus PF16131.5 ETS60236.1 - 2.1 9.1 7.4 7.3 7.3 0.4 2.7 1 1 1 2 2 2 0 Torus domain Paf1 PF03985.13 ETS60237.1 - 7.4e-57 193.2 9.0 1e-50 173.0 0.1 3.4 1 1 1 2 2 2 2 Paf1 DUF5529 PF17669.1 ETS60237.1 - 0.055 13.5 1.8 0.13 12.3 1.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5529) Zn_clus PF00172.18 ETS60238.1 - 1.1e-06 28.6 10.3 2.1e-06 27.7 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MAP65_ASE1 PF03999.12 ETS60238.1 - 0.014 14.1 3.8 0.015 14.0 3.8 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) MGC-24 PF05283.11 ETS60238.1 - 0.19 12.2 8.4 0.032 14.7 4.6 1.7 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PSI_integrin PF17205.3 ETS60238.1 - 1.1 9.0 8.9 0.37 10.6 6.0 1.7 1 1 0 1 1 1 0 Integrin plexin domain SR-25 PF10500.9 ETS60238.1 - 2.5 7.7 9.9 4 7.0 9.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Skp1 PF01466.19 ETS60239.1 - 2.1e-26 91.7 0.1 4.1e-26 90.8 0.1 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETS60239.1 - 6.7e-26 90.3 1.0 1.2e-25 89.4 0.1 1.9 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain BTB PF00651.31 ETS60239.1 - 0.019 15.2 0.0 0.25 11.6 0.0 2.2 1 1 0 1 1 1 0 BTB/POZ domain MTHFR PF02219.17 ETS60240.1 - 1.8e-111 372.1 0.0 2.8e-111 371.4 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF2183 PF09949.9 ETS60241.1 - 9.8e-24 83.6 0.0 5.7e-23 81.1 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 ETS60241.1 - 0.16 11.4 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) VHS PF00790.19 ETS60242.1 - 3.4e-29 101.5 0.5 7.8e-29 100.3 0.5 1.6 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 ETS60242.1 - 1.5e-16 59.7 0.0 3.1e-16 58.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS60242.1 - 3.3e-15 55.7 0.2 6.6e-15 54.7 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETS60242.1 - 5.5e-12 45.2 0.1 1.1e-11 44.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 ETS60242.1 - 4.6e-09 36.4 1.8 1e-08 35.4 0.6 2.2 2 0 0 2 2 2 1 GAT domain Hrs_helical PF12210.8 ETS60242.1 - 0.0016 18.9 0.6 0.0016 18.9 0.6 2.1 2 0 0 2 2 2 1 Hepatocyte growth factor-regulated tyrosine kinase substrate UIM PF02809.20 ETS60242.1 - 0.014 15.2 3.8 0.014 15.2 3.8 2.4 2 0 0 2 2 2 0 Ubiquitin interaction motif Cyt-b5 PF00173.28 ETS60243.1 - 8.5e-20 70.7 0.0 1.3e-19 70.1 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DASH_Spc34 PF08657.10 ETS60244.1 - 9e-05 22.4 2.0 0.022 14.6 0.1 2.8 3 0 0 3 3 3 2 DASH complex subunit Spc34 A_deaminase PF00962.22 ETS60245.1 - 1.6e-121 405.7 0.1 2.2e-121 405.2 0.1 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Rep_fac_C PF08542.11 ETS60246.1 - 4.3e-21 75.1 0.0 9e-21 74.1 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 ETS60246.1 - 5.6e-17 62.4 0.0 1.1e-16 61.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ETS60246.1 - 2e-15 56.9 0.0 7.6e-11 42.1 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 ETS60246.1 - 1.1e-09 38.5 0.0 3.4e-09 36.9 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_24 PF13479.6 ETS60246.1 - 1.2e-05 25.1 0.0 2.8e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS60246.1 - 2.2e-05 24.3 0.0 8.7e-05 22.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ETS60246.1 - 2.3e-05 23.7 0.0 3.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 ETS60246.1 - 5e-05 23.2 0.1 0.0003 20.7 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 ETS60246.1 - 8.6e-05 22.8 0.2 0.00037 20.8 0.0 2.2 3 0 0 3 3 1 1 AAA C-terminal domain RuvB_N PF05496.12 ETS60246.1 - 9.7e-05 22.2 0.0 0.00023 21.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ETS60246.1 - 0.00017 21.2 0.0 0.00031 20.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 ETS60246.1 - 0.00017 21.9 0.1 0.031 14.5 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETS60246.1 - 0.00019 21.5 0.0 0.0015 18.5 0.0 2.5 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETS60246.1 - 0.00023 21.6 0.0 0.00049 20.5 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ETS60246.1 - 0.0006 19.8 0.0 0.0023 17.9 0.0 1.9 1 1 1 2 2 2 1 AAA domain WGG PF10273.9 ETS60246.1 - 0.0025 18.4 0.0 0.058 14.1 0.0 2.4 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 ResIII PF04851.15 ETS60246.1 - 0.0061 16.6 0.0 0.052 13.5 0.0 2.0 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETS60246.1 - 0.0079 16.5 0.1 0.037 14.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 ETS60246.1 - 0.012 15.1 0.0 0.27 10.6 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein AAA_3 PF07726.11 ETS60246.1 - 0.013 15.4 0.0 0.027 14.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ETS60246.1 - 0.019 14.0 0.0 0.047 12.7 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein DNA_pol3_delta PF06144.13 ETS60246.1 - 0.02 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase III, delta subunit DEAD PF00270.29 ETS60246.1 - 0.035 13.9 0.1 0.26 11.0 0.1 2.2 1 1 1 2 2 2 0 DEAD/DEAH box helicase MCM PF00493.23 ETS60246.1 - 0.047 12.8 0.0 0.077 12.1 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain IstB_IS21 PF01695.17 ETS60246.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETS60246.1 - 0.057 12.8 0.0 0.48 9.8 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ETS60246.1 - 0.058 13.0 0.0 0.16 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ETS60246.1 - 0.059 13.1 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_28 PF13521.6 ETS60246.1 - 0.061 13.6 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETS60246.1 - 0.1 13.0 0.0 0.32 11.4 0.0 2.0 2 0 0 2 2 1 0 RNA helicase Nucleopor_Nup85 PF07575.13 ETS60247.1 - 2e-87 294.1 0.0 2.1e-52 178.5 0.1 2.5 2 1 0 2 2 2 2 Nup85 Nucleoporin zf-C2H2_jaz PF12171.8 ETS60248.1 - 3.4e-09 36.7 0.5 5.2e-09 36.1 0.5 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ETS60248.1 - 0.006 16.9 0.0 0.006 16.9 0.0 1.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ETS60248.1 - 0.011 16.1 0.2 0.018 15.5 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ETS60248.1 - 0.024 15.1 0.4 0.024 15.1 0.4 1.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS60248.1 - 0.11 13.4 0.1 0.11 13.4 0.1 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Ribosomal_L35Ae PF01247.18 ETS60249.1 - 2.1e-42 143.2 2.2 3.2e-42 142.6 2.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 ETS60249.1 - 0.08 13.2 0.1 4.7 7.5 0.0 2.4 2 1 0 2 2 2 0 RimM N-terminal domain Scm3 PF10384.9 ETS60250.1 - 6.4e-15 54.6 0.2 6.4e-15 54.6 0.2 3.2 3 0 0 3 3 3 1 Centromere protein Scm3 DNA_pol_phi PF04931.13 ETS60250.1 - 7 4.6 17.4 14 3.6 17.4 1.4 1 0 0 1 1 1 0 DNA polymerase phi ACC_central PF08326.12 ETS60252.1 - 6.3e-207 689.2 0.0 8.6e-207 688.8 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 ETS60252.1 - 2.4e-176 587.2 0.0 3.2e-176 586.8 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 ETS60252.1 - 2e-53 181.0 0.0 4.2e-53 180.0 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ETS60252.1 - 2.1e-28 99.1 0.1 5e-28 97.9 0.1 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ETS60252.1 - 4.4e-21 75.0 0.0 9.7e-20 70.7 0.0 2.8 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ETS60252.1 - 1.2e-14 53.9 0.2 2.6e-14 52.8 0.2 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ETS60252.1 - 2.5e-06 27.2 0.0 1.3e-05 24.9 0.0 2.2 1 0 0 1 1 1 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 ETS60252.1 - 0.0008 19.0 0.0 0.0029 17.2 0.0 1.9 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ETS60252.1 - 0.0015 18.2 0.1 0.0034 17.0 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ETS60252.1 - 0.0073 16.4 0.2 0.03 14.4 0.0 2.1 3 0 0 3 3 3 1 ATP-grasp domain RnfC_N PF13375.6 ETS60252.1 - 0.013 15.5 0.5 0.05 13.6 0.1 2.1 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain ERCC4 PF02732.15 ETS60253.1 - 6.1e-22 78.5 0.0 1e-21 77.8 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 ETS60253.1 - 0.0019 18.5 0.0 0.0086 16.4 0.0 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cytochrom_C1 PF02167.15 ETS60254.1 - 7.4e-97 323.4 0.0 1e-96 322.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ETS60254.1 - 0.0026 18.0 0.0 0.0058 16.9 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ETS60254.1 - 0.14 13.3 0.1 0.42 11.8 0.0 1.9 2 0 0 2 2 2 0 Cytochrome c Ribosomal_S19 PF00203.21 ETS60255.1 - 9.4e-30 102.3 0.2 1.8e-29 101.4 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S19 ALC PF17527.2 ETS60255.1 - 0.021 14.4 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 Phage ALC protein Ribosomal_L5e PF17144.4 ETS60256.1 - 1.1e-79 266.1 0.0 2.1e-79 265.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ETS60256.1 - 9.2e-32 109.9 4.6 9.2e-32 109.9 4.6 1.7 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 ETS60256.1 - 0.034 14.5 1.5 0.049 14.0 0.1 2.0 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast DUF5388 PF17363.2 ETS60256.1 - 0.051 13.8 0.0 0.8 10.0 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5388) DUF5104 PF17117.5 ETS60256.1 - 0.11 12.9 1.2 0.23 11.9 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5104) Spore_III_AB PF09548.10 ETS60256.1 - 0.15 12.1 0.6 0.27 11.4 0.6 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Ribosomal_L15e PF00827.17 ETS60257.1 - 4.4e-83 277.7 12.2 8.2e-77 257.2 10.1 2.1 2 0 0 2 2 2 2 Ribosomal L15 UBA_6 PF18039.1 ETS60257.1 - 0.17 11.9 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 UBA-like domain EAP30 PF04157.16 ETS60258.1 - 1.1e-66 224.5 0.0 1.3e-66 224.3 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family TB2_DP1_HVA22 PF03134.19 ETS60259.1 - 1.7e-25 88.7 11.1 2.7e-25 88.1 11.1 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family DUF2304 PF10066.9 ETS60259.1 - 0.0078 16.4 0.6 0.012 15.8 0.6 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2304) Zn_clus PF00172.18 ETS60260.1 - 8.7e-07 29.0 6.1 0.00099 19.2 0.8 2.2 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Cytochrom_B558a PF05038.13 ETS60261.1 - 0.31 10.6 3.8 0.27 10.8 1.0 2.1 1 1 1 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit Foie-gras_1 PF11817.8 ETS60262.1 - 2.4e-27 96.1 0.0 4.2e-26 92.1 0.0 2.7 2 1 0 2 2 2 1 Foie gras liver health family 1 ALGX PF16822.5 ETS60262.1 - 0.039 13.6 0.0 0.091 12.4 0.0 1.5 1 0 0 1 1 1 0 SGNH hydrolase-like domain, acetyltransferase AlgX Gryzun PF07919.12 ETS60262.1 - 0.079 11.7 0.0 0.16 10.7 0.0 1.5 2 0 0 2 2 2 0 Gryzun, putative trafficking through Golgi TPR_12 PF13424.6 ETS60262.1 - 3.2 8.1 12.8 0.94 9.8 3.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat PRCC PF10253.9 ETS60263.1 - 2.8e-16 60.9 5.3 2.8e-16 60.9 5.3 3.5 3 2 0 3 3 3 2 Mitotic checkpoint regulator, MAD2B-interacting Peptidase_S10 PF00450.22 ETS60264.1 - 1.2e-104 351.0 0.0 1.5e-104 350.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase PI-PLC-X PF00388.19 ETS60267.1 - 8.6e-08 31.9 0.0 1.4e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain TraK PF06586.11 ETS60267.1 - 0.093 12.4 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 TraK protein YL1_C PF08265.11 ETS60268.1 - 2.2e-14 52.9 0.4 2.2e-14 52.9 0.4 1.7 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Presenilin PF01080.17 ETS60268.1 - 1.6 7.4 5.2 1.8 7.2 5.2 1.1 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 ETS60268.1 - 1.7 7.9 17.5 2.2 7.6 17.5 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Apt1 PF10351.9 ETS60270.1 - 0.38 9.5 4.7 0.57 9.0 4.7 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Prefoldin_2 PF01920.20 ETS60271.1 - 4.1e-19 68.5 3.5 5.4e-19 68.1 3.5 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 ETS60271.1 - 0.004 17.1 2.1 0.0067 16.3 2.1 1.4 1 1 0 1 1 1 1 Prefoldin subunit PI3K_P85_iSH2 PF16454.5 ETS60271.1 - 0.0048 16.5 3.5 0.021 14.4 3.3 1.8 1 1 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GvpK PF05121.12 ETS60271.1 - 0.0057 16.7 4.6 0.023 14.7 4.0 2.1 1 1 1 2 2 2 1 Gas vesicle protein K DUF5064 PF16703.5 ETS60271.1 - 0.025 15.0 0.4 0.13 12.7 0.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5064) FAM167 PF11652.8 ETS60271.1 - 1 9.9 4.3 2.2 8.8 0.5 2.5 1 1 0 2 2 2 0 FAM167 Glyco_trans_4_4 PF13579.6 ETS60272.1 - 5.2e-10 40.0 10.4 5.2e-10 40.0 10.4 2.8 2 1 1 3 3 3 1 Glycosyl transferase 4-like domain Glyco_trans_1_4 PF13692.6 ETS60272.1 - 1.1e-06 29.1 0.0 3.9e-06 27.3 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ETS60272.1 - 4.3e-05 23.6 3.7 8.9e-05 22.6 3.7 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 ETS60272.1 - 0.00055 20.3 0.0 0.0013 19.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 ETS60272.1 - 0.017 14.6 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF1992 PF09350.10 ETS60273.1 - 8.1e-21 74.0 2.8 2.9e-20 72.2 0.3 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1992) Ntox34 PF15606.6 ETS60273.1 - 0.11 12.6 0.1 22 5.3 0.1 2.8 2 0 0 2 2 2 0 Bacterial toxin 34 Dynein_light PF01221.18 ETS60274.1 - 5.5e-35 119.5 0.3 6.5e-35 119.3 0.3 1.1 1 0 0 1 1 1 1 Dynein light chain type 1 Imm48 PF15574.6 ETS60274.1 - 0.07 12.9 0.1 0.098 12.4 0.1 1.1 1 0 0 1 1 1 0 Immunity protein 48 Suc_Fer-like PF06999.12 ETS60276.1 - 1.1e-24 87.5 0.0 2.1e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 Sucrase/ferredoxin-like LIAS_N PF16881.5 ETS60276.1 - 2e-20 73.2 0.0 5.8e-20 71.7 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 ETS60276.1 - 4.2e-13 50.0 0.0 1e-12 48.7 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily LRR_9 PF14580.6 ETS60277.1 - 2.8e-57 193.0 0.2 4e-57 192.5 0.2 1.2 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ETS60277.1 - 2.3e-11 43.7 7.1 1.4e-07 31.7 0.3 3.4 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETS60277.1 - 3.8e-08 33.0 4.6 3.1e-07 30.0 3.2 2.8 3 1 0 3 3 3 1 Leucine rich repeat Viral_P18 PF04521.13 ETS60277.1 - 0.1 12.4 0.0 6.6 6.5 0.0 2.5 2 1 0 2 2 2 0 ssRNA positive strand viral 18kD cysteine rich protein MFS_1 PF07690.16 ETS60278.1 - 2.3e-19 69.5 37.6 2.3e-19 69.5 37.6 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ETS60278.1 - 0.00043 18.7 4.1 0.00043 18.7 4.1 2.6 2 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family CRAL_TRIO_2 PF13716.6 ETS60279.1 - 3e-33 114.9 0.0 5.1e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 ETS60279.1 - 7e-25 87.6 0.0 1.5e-24 86.5 0.0 1.6 1 1 0 1 1 1 1 RhoGAP domain AAA PF00004.29 ETS60280.1 - 3.7e-49 166.5 0.0 3.9e-41 140.6 0.0 2.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) WD40 PF00400.32 ETS60280.1 - 3.3e-34 116.3 25.1 1.2e-08 35.4 0.8 8.5 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60280.1 - 3.3e-13 49.7 0.3 0.00036 20.8 0.0 5.4 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain AAA_lid_3 PF17862.1 ETS60280.1 - 4.7e-09 35.9 0.6 1.7e-08 34.1 0.1 2.3 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 ETS60280.1 - 3.2e-07 30.9 4.6 9.1e-05 22.9 0.0 4.2 3 1 1 4 4 4 1 AAA ATPase domain IstB_IS21 PF01695.17 ETS60280.1 - 3.2e-05 23.7 0.0 6.7e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_2 PF07724.14 ETS60280.1 - 6.4e-05 23.1 0.0 0.00028 21.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ETS60280.1 - 0.00028 21.1 2.4 0.096 12.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain Ge1_WD40 PF16529.5 ETS60280.1 - 0.00031 19.8 0.1 0.32 9.9 0.0 3.4 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein AAA_5 PF07728.14 ETS60280.1 - 0.0015 18.5 0.0 0.0095 15.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETS60280.1 - 0.0078 16.8 0.0 0.072 13.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETS60280.1 - 0.01 16.1 0.2 0.24 11.7 0.1 3.2 3 1 0 3 3 3 0 AAA domain AFG1_ATPase PF03969.16 ETS60280.1 - 0.036 12.9 0.7 1.3 7.8 0.0 2.6 3 0 0 3 3 3 0 AFG1-like ATPase DUF2075 PF09848.9 ETS60280.1 - 0.052 12.8 0.0 0.15 11.2 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 ETS60280.1 - 0.098 12.4 0.0 1.5 8.5 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETS60280.1 - 0.1 13.0 0.0 0.3 11.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase TIP49 PF06068.13 ETS60280.1 - 0.11 11.6 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_7 PF12775.7 ETS60280.1 - 0.12 11.9 0.0 0.49 9.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region Bromodomain PF00439.25 ETS60280.1 - 0.12 12.4 0.1 0.29 11.2 0.1 1.6 1 0 0 1 1 1 0 Bromodomain Sigma54_activ_2 PF14532.6 ETS60280.1 - 0.15 12.2 0.0 1 9.5 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain ResIII PF04851.15 ETS60280.1 - 0.17 11.9 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit FGGY_N PF00370.21 ETS60281.1 - 1.7e-72 243.9 0.4 2.3e-72 243.5 0.4 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ETS60281.1 - 2.9e-64 216.5 1.4 1.6e-63 214.0 1.0 2.1 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain TANGO2 PF05742.12 ETS60282.1 - 1.6e-42 146.3 0.0 2.1e-42 145.9 0.0 1.1 1 0 0 1 1 1 1 Transport and Golgi organisation 2 TFIIS_C PF01096.18 ETS60282.1 - 5.2e-10 39.0 0.1 5.2e-10 39.0 0.1 2.2 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ETS60282.1 - 3.5e-09 36.4 2.3 3.5e-09 36.4 2.3 2.3 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 ETS60282.1 - 0.58 10.2 4.1 14 5.7 0.0 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PHD PF00628.29 ETS60282.1 - 3.2 7.7 7.4 0.31 11.0 2.4 1.9 2 0 0 2 2 2 0 PHD-finger PhnA_Zn_Ribbon PF08274.12 ETS60282.1 - 4.6 7.3 6.9 4.6 7.3 0.0 3.0 3 0 0 3 3 3 0 PhnA Zinc-Ribbon Ribosomal_S19e PF01090.19 ETS60283.1 - 3.1e-56 188.9 0.0 3.7e-56 188.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19e 4HBT PF03061.22 ETS60284.1 - 1.4e-10 41.3 0.1 2.9e-10 40.4 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 ETS60284.1 - 0.017 15.2 0.1 0.022 14.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4442) DHDPS PF00701.22 ETS60285.1 - 2.9e-40 137.8 0.0 3.4e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family ParA PF10609.9 ETS60286.1 - 2.1e-76 256.6 0.1 3e-76 256.1 0.1 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ETS60286.1 - 1.4e-10 41.3 0.0 6.1e-10 39.2 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ETS60286.1 - 1.6e-06 28.1 0.1 0.00019 21.4 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_26 PF13500.6 ETS60286.1 - 7.7e-05 22.6 1.0 0.00042 20.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain ArsA_ATPase PF02374.15 ETS60286.1 - 0.00018 20.8 2.3 0.00068 18.9 0.4 2.3 2 1 0 2 2 2 1 Anion-transporting ATPase MipZ PF09140.11 ETS60286.1 - 0.00023 20.6 0.4 0.0014 18.0 0.1 2.0 1 1 0 2 2 2 1 ATPase MipZ AAA_25 PF13481.6 ETS60286.1 - 0.0005 19.7 0.7 0.0018 17.9 0.7 1.9 1 1 0 1 1 1 1 AAA domain Fer4_NifH PF00142.18 ETS60286.1 - 0.0022 17.5 0.1 0.065 12.7 0.1 2.3 2 1 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DNA_ligase_A_M PF01068.21 ETS60287.1 - 7e-36 123.8 0.0 7e-27 94.4 0.0 3.4 3 0 0 3 3 3 3 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ETS60287.1 - 4e-33 115.2 0.0 6.9e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ETS60287.1 - 3.4e-18 66.1 0.0 8.9e-18 64.7 0.0 1.8 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region CbtB PF09489.10 ETS60288.1 - 0.048 13.8 1.5 0.72 10.0 0.3 3.0 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtB) CTP_transf_1 PF01148.20 ETS60288.1 - 0.11 12.3 1.8 0.23 11.2 1.8 1.5 1 0 0 1 1 1 0 Cytidylyltransferase family Esterase_phd PF10503.9 ETS60289.1 - 2.2e-15 56.8 0.4 2.2e-15 56.8 0.4 2.0 2 0 0 2 2 2 1 Esterase PHB depolymerase Peptidase_S9 PF00326.21 ETS60289.1 - 2.5e-13 50.0 1.5 6.4e-13 48.7 1.5 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 ETS60289.1 - 0.0019 17.9 0.2 0.0038 16.9 0.2 1.4 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ETS60289.1 - 0.02 14.2 0.1 0.47 9.7 0.1 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Hydrolase_6 PF13344.6 ETS60294.1 - 1e-22 80.1 0.0 1.7e-22 79.4 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS60294.1 - 1.1e-19 70.2 0.0 2.4e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like DUF829 PF05705.14 ETS60295.1 - 7.8e-23 81.6 0.0 2.2e-17 63.8 0.0 3.1 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF829) MFS_1 PF07690.16 ETS60296.1 - 7.8e-24 84.3 47.2 7.8e-24 84.3 47.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Flavi_M PF01004.19 ETS60296.1 - 0.086 12.6 0.7 0.74 9.6 0.0 2.3 2 0 0 2 2 2 0 Flavivirus envelope glycoprotein M RRM_1 PF00076.22 ETS60297.1 - 2.4e-33 113.8 0.0 4.7e-18 64.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ETS60297.1 - 5.5e-05 23.5 0.0 0.44 10.8 0.0 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 ETS60297.1 - 0.00013 22.0 0.0 0.00082 19.4 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif RRM_5 PF13893.6 ETS60297.1 - 0.0003 20.4 0.0 0.2 11.2 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ETS60297.1 - 0.00096 19.2 0.1 0.21 11.7 0.0 2.2 2 0 0 2 2 2 2 Limkain b1 OB_RNB PF08206.11 ETS60297.1 - 0.078 12.7 0.1 2.8 7.7 0.0 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain Rab5ip PF07019.12 ETS60298.1 - 1.4e-16 60.8 5.2 3.5e-16 59.5 5.2 1.6 1 1 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF3099 PF11298.8 ETS60298.1 - 0.063 13.4 1.5 0.14 12.3 1.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3099) Shugoshin_C PF07557.11 ETS60299.1 - 3e-07 30.1 3.4 3e-07 30.1 3.4 2.9 3 0 0 3 3 3 1 Shugoshin C terminus Shugoshin_N PF07558.11 ETS60299.1 - 5.7e-07 29.3 1.5 1.1e-06 28.4 1.5 1.4 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Myb_DNA-bind_2 PF08914.11 ETS60300.1 - 0.0011 19.1 1.0 0.58 10.4 0.0 2.7 2 0 0 2 2 2 2 Rap1 Myb domain BRCT_2 PF16589.5 ETS60300.1 - 0.19 12.1 0.0 0.46 10.9 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Rap1-DNA-bind PF09197.10 ETS60300.1 - 0.33 11.6 9.4 0.19 12.3 0.3 2.9 2 0 0 2 2 2 0 Rap1, DNA-binding KH_6 PF15985.5 ETS60301.1 - 1.5e-12 47.7 0.0 3.3e-12 46.6 0.0 1.6 1 0 0 1 1 1 1 KH domain ECR1_N PF14382.6 ETS60301.1 - 1.3e-05 24.9 0.0 2.2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region DUF5586 PF17824.1 ETS60301.1 - 0.065 12.3 0.1 0.092 11.8 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5586) ABC_membrane PF00664.23 ETS60302.1 - 4e-50 171.0 31.2 9.2e-33 114.1 7.7 3.7 4 0 0 4 4 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS60302.1 - 3.8e-49 166.7 0.1 5.1e-29 101.5 0.0 3.1 3 0 0 3 3 2 2 ABC transporter DUF87 PF01935.17 ETS60302.1 - 5.2e-08 33.3 0.5 0.0037 17.4 0.1 2.7 2 0 0 2 2 2 2 Helicase HerA, central domain SMC_N PF02463.19 ETS60302.1 - 2.3e-07 30.5 7.1 0.019 14.4 0.0 4.3 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS60302.1 - 7.9e-07 28.7 0.7 0.0071 16.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain TrwB_AAD_bind PF10412.9 ETS60302.1 - 4.8e-06 25.7 0.1 0.049 12.5 0.0 2.4 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.6 ETS60302.1 - 8.2e-06 26.5 1.9 0.0018 18.8 0.0 2.7 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.6 ETS60302.1 - 1.6e-05 24.9 3.8 0.13 12.0 0.1 3.6 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ETS60302.1 - 3.4e-05 24.3 14.1 0.001 19.5 0.1 4.2 3 2 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 ETS60302.1 - 4.9e-05 23.4 0.0 0.13 12.3 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_30 PF13604.6 ETS60302.1 - 0.00034 20.4 0.8 0.11 12.2 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETS60302.1 - 0.00048 20.4 0.1 2.6 8.3 0.0 3.7 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 ETS60302.1 - 0.00074 19.5 0.6 0.28 11.1 0.0 2.8 3 0 0 3 3 2 1 RsgA GTPase CbiA PF01656.23 ETS60302.1 - 0.003 17.6 0.0 0.1 12.7 0.0 2.9 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 ETS60302.1 - 0.0041 16.7 0.0 0.88 9.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ETS60302.1 - 0.0055 16.5 0.1 4.9 6.9 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein T2SSE PF00437.20 ETS60302.1 - 0.0077 15.3 0.0 0.23 10.5 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein NACHT PF05729.12 ETS60302.1 - 0.012 15.6 1.5 3 7.7 0.0 2.9 3 0 0 3 3 2 0 NACHT domain UPF0114 PF03350.16 ETS60302.1 - 0.013 15.7 1.0 0.36 11.0 0.1 3.3 2 0 0 2 2 2 0 Uncharacterized protein family, UPF0114 AAA_15 PF13175.6 ETS60302.1 - 0.017 14.9 0.1 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_7 PF12775.7 ETS60302.1 - 0.019 14.5 0.1 2.3 7.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 ETS60302.1 - 0.021 15.2 0.1 13 6.2 0.0 3.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ETS60302.1 - 0.021 14.6 0.0 24 4.6 0.0 3.5 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_10 PF12846.7 ETS60302.1 - 0.022 13.7 1.5 0.33 9.8 0.0 2.5 3 0 0 3 3 3 0 AAA-like domain Dynamin_N PF00350.23 ETS60302.1 - 0.025 14.7 2.1 0.95 9.5 0.1 2.7 2 0 0 2 2 2 0 Dynamin family Roc PF08477.13 ETS60302.1 - 0.027 14.7 0.3 14 5.9 0.0 3.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 ETS60302.1 - 0.03 14.7 0.1 16 5.9 0.0 2.8 2 0 0 2 2 2 0 RNA helicase DUF815 PF05673.13 ETS60302.1 - 0.048 12.8 0.0 11 5.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 ETS60302.1 - 0.062 12.6 0.3 4.9 6.4 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_5 PF07728.14 ETS60302.1 - 0.092 12.7 0.1 31 4.5 0.0 3.1 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) cobW PF02492.19 ETS60302.1 - 0.093 12.3 0.0 0.52 9.9 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_27 PF13514.6 ETS60302.1 - 0.095 12.3 0.0 0.22 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETS60302.1 - 0.098 12.8 1.5 23 5.1 0.4 3.8 3 1 0 3 3 3 0 AAA domain AAA_24 PF13479.6 ETS60302.1 - 0.12 12.1 0.0 5.1 6.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETS60302.1 - 0.13 12.8 0.1 48 4.5 0.0 3.3 3 0 0 3 3 2 0 AAA domain CLP1_P PF16575.5 ETS60302.1 - 0.36 10.6 1.9 1e+02 2.6 0.1 3.6 4 0 0 4 4 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop SbcCD_C PF13558.6 ETS60302.1 - 0.43 10.9 6.4 0.29 11.4 0.4 3.1 3 0 0 3 3 2 0 Putative exonuclease SbcCD, C subunit AAA_11 PF13086.6 ETS60302.1 - 2.4 7.9 5.8 2.5 7.8 0.0 3.3 3 1 1 4 4 4 0 AAA domain FAD_binding_4 PF01565.23 ETS60303.1 - 2.3e-23 82.5 0.8 3.9e-23 81.7 0.8 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ETS60303.1 - 1.1e-09 38.2 0.0 2.1e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Berberine and berberine like mRNA_triPase PF02940.15 ETS60304.1 - 2e-54 184.6 0.1 2.4e-54 184.3 0.1 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain DEAD PF00270.29 ETS60305.1 - 4e-17 62.5 0.0 3.1e-16 59.7 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS60305.1 - 9.3e-15 54.9 0.0 1.8e-12 47.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ETS60305.1 - 4.3e-12 46.6 1.0 1.2e-11 45.1 1.0 1.9 1 0 0 1 1 1 1 RecQ zinc-binding ResIII PF04851.15 ETS60305.1 - 4.5e-05 23.5 0.0 0.00014 21.9 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ETS60305.1 - 0.066 13.5 0.0 5.5 7.3 0.0 3.2 3 0 0 3 3 3 0 AAA domain SecA_DEAD PF07517.14 ETS60305.1 - 0.075 12.3 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain RPE65 PF03055.15 ETS60306.1 - 2.1e-101 340.4 0.2 2.7e-101 340.1 0.2 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein FAD_binding_4 PF01565.23 ETS60307.1 - 9.5e-23 80.5 0.0 1.5e-22 79.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain ADH_zinc_N_2 PF13602.6 ETS60308.1 - 2.4e-16 61.0 0.0 6.6e-16 59.6 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ETS60308.1 - 4.9e-15 55.6 0.0 9.6e-15 54.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ETS60308.1 - 1.2e-05 25.1 0.0 9.7e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_N PF08240.12 ETS60308.1 - 0.00034 20.5 0.1 0.00088 19.1 0.1 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain FA_hydroxylase PF04116.13 ETS60309.1 - 5.6e-19 68.8 14.1 1.3e-18 67.6 14.1 1.7 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily MscS_TM PF12794.7 ETS60309.1 - 0.14 10.9 3.9 0.34 9.7 3.9 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 PALP PF00291.25 ETS60310.1 - 4.8e-48 164.1 2.3 5.9e-48 163.8 2.3 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme adh_short PF00106.25 ETS60311.1 - 5.2e-22 78.3 0.5 1.3e-19 70.5 1.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60311.1 - 1.8e-14 53.8 0.4 1.8e-13 50.6 0.7 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase M20_dimer PF07687.14 ETS60311.1 - 9e-11 41.7 0.0 2.1e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain KR PF08659.10 ETS60311.1 - 1.3e-08 34.9 0.9 2.7e-08 33.9 0.9 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETS60311.1 - 9.6e-05 21.6 0.3 0.00012 21.3 0.3 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein MHCassoc_trimer PF08831.10 ETS60311.1 - 0.0016 18.4 0.1 0.0035 17.3 0.1 1.5 1 0 0 1 1 1 1 Class II MHC-associated invariant chain trimerisation domain Epimerase PF01370.21 ETS60311.1 - 0.0048 16.4 0.1 0.12 11.8 0.1 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS60311.1 - 0.01 14.8 0.3 0.014 14.4 0.3 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Peripla_BP_6 PF13458.6 ETS60311.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein GDP_Man_Dehyd PF16363.5 ETS60311.1 - 0.04 13.3 0.1 1 8.7 0.1 2.2 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ETS60311.1 - 0.083 12.8 0.4 0.16 11.8 0.4 1.5 1 0 0 1 1 1 0 NAD(P)H-binding Fungal_trans PF04082.18 ETS60312.1 - 2.2e-20 72.8 0.0 3.8e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS60312.1 - 9e-07 28.9 10.7 9e-07 28.9 10.7 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHDPS PF00701.22 ETS60313.1 - 7.3e-39 133.2 0.0 8.7e-39 132.9 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family LAT PF15234.6 ETS60314.1 - 0.14 11.9 3.1 0.23 11.2 3.1 1.4 1 0 0 1 1 1 0 Linker for activation of T-cells Mad3_BUB1_I PF08311.12 ETS60315.1 - 1.3e-41 141.4 0.1 2.2e-41 140.7 0.1 1.4 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase PF00069.25 ETS60315.1 - 3.6e-08 33.1 0.0 8.8e-07 28.6 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Ribosomal_S11 PF00411.19 ETS60315.1 - 0.089 13.2 3.4 0.089 13.2 0.3 2.6 3 0 0 3 3 3 0 Ribosomal protein S11 Kdo PF06293.14 ETS60315.1 - 0.13 11.6 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PEHE PF15275.6 ETS60316.1 - 0.00022 21.9 7.4 0.00022 21.9 7.4 4.5 3 2 0 3 3 3 1 PEHE domain SAS4 PF15460.6 ETS60316.1 - 0.0064 16.6 2.4 0.0064 16.6 2.4 1.8 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 EF-hand_1 PF00036.32 ETS60317.1 - 3.8e-21 73.0 0.1 1.8e-05 23.9 0.0 4.6 4 1 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ETS60317.1 - 3e-19 67.2 0.1 5e-06 26.0 0.1 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ETS60317.1 - 9e-17 61.3 0.2 2.1e-07 31.3 0.0 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETS60317.1 - 2.3e-16 58.4 0.0 0.00032 20.1 0.0 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETS60317.1 - 4e-14 52.2 0.3 5.6e-07 29.3 0.0 3.8 3 2 1 4 4 4 2 EF-hand domain pair Mucin-like PF16058.5 ETS60317.1 - 0.2 11.8 16.8 0.19 11.8 14.8 1.9 2 1 0 2 2 2 0 Mucin-like Extensin_2 PF04554.13 ETS60317.1 - 3.5 7.8 18.7 1.8 8.7 11.2 2.2 1 1 1 2 2 2 0 Extensin-like region Cation_efflux PF01545.21 ETS60318.1 - 1.8e-46 158.4 12.7 1.8e-46 158.4 12.7 2.6 2 0 0 2 2 2 1 Cation efflux family Zip PF02535.22 ETS60318.1 - 0.93 8.6 29.5 1.3 8.2 14.7 3.6 3 0 0 3 3 3 0 ZIP Zinc transporter DUF92 PF01940.16 ETS60319.1 - 4.2e-72 242.4 12.4 4.9e-72 242.1 12.4 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 COG6 PF06419.11 ETS60320.1 - 3.1e-153 511.3 0.0 3.8e-153 511.0 0.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Ribosomal_S11 PF00411.19 ETS60321.1 - 8.8e-12 45.4 0.6 1.7e-11 44.5 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S11 SPX PF03105.19 ETS60321.1 - 1.2 9.0 9.8 1.4 8.7 9.8 1.2 1 0 0 1 1 1 0 SPX domain Glyco_hydro_17 PF00332.18 ETS60322.1 - 1.5e-10 41.2 0.1 8.3e-08 32.2 0.1 2.3 2 0 0 2 2 2 2 Glycosyl hydrolases family 17 Wzz PF02706.15 ETS60322.1 - 0.013 15.8 0.1 0.044 14.1 0.0 1.9 2 0 0 2 2 2 0 Chain length determinant protein DUF3446 PF11928.8 ETS60322.1 - 3.5 8.0 8.4 24 5.3 3.8 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain Pro-kuma_activ PF09286.11 ETS60323.1 - 7.6e-34 117.0 0.1 2e-33 115.7 0.0 1.8 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 ETS60323.1 - 0.00076 18.8 1.2 0.0012 18.1 1.2 1.2 1 0 0 1 1 1 1 Subtilase family PAE PF03283.13 ETS60324.1 - 3.3e-14 52.8 0.9 6.8e-14 51.8 0.9 1.5 1 0 0 1 1 1 1 Pectinacetylesterase DUF4091 PF13320.6 ETS60324.1 - 0.032 14.4 1.1 0.1 12.8 1.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) Apt1 PF10351.9 ETS60324.1 - 1.2 7.9 7.0 1.7 7.4 7.0 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 ETS60324.1 - 2.2 7.4 20.4 3.2 6.8 20.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 ETS60324.1 - 2.4 8.0 6.3 3.6 7.4 6.3 1.2 1 0 0 1 1 1 0 SPX domain PAN_3 PF08277.12 ETS60324.1 - 4.3 7.2 6.5 0.67 9.8 1.7 2.1 2 0 0 2 2 2 0 PAN-like domain Glyco_hydro_115 PF15979.5 ETS60325.1 - 6.5e-128 426.9 0.0 9.3e-128 426.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 115 GH115_C PF17829.1 ETS60325.1 - 2.9e-32 111.9 0.0 5.8e-32 110.9 0.0 1.5 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain UCR_UQCRX_QCR9 PF05365.12 ETS60327.1 - 1.4e-19 69.7 10.5 2.2e-18 65.9 3.1 2.1 2 0 0 2 2 2 2 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like RNase_HII PF01351.18 ETS60330.1 - 8.5e-45 153.0 0.0 2.8e-40 138.3 0.0 2.2 2 0 0 2 2 2 2 Ribonuclease HII DNA_pol_A_exo1 PF01612.20 ETS60331.1 - 6e-40 136.8 1.1 7.4e-40 136.5 0.3 1.6 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 ETS60331.1 - 6.9e-24 84.4 3.1 6.9e-24 84.4 3.1 2.8 2 1 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 ETS60331.1 - 5.2e-12 45.6 0.5 1.3e-11 44.3 0.5 1.8 1 0 0 1 1 1 1 HRDC domain DUF2718 PF10918.8 ETS60331.1 - 1.7 9.2 3.6 4.1 7.9 3.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2718) YchF-GTPase_C PF06071.13 ETS60332.1 - 2.9e-33 113.9 1.3 1.1e-32 112.1 0.2 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ETS60332.1 - 6.9e-17 61.6 0.0 2.7e-16 59.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETS60332.1 - 2.3e-05 24.0 0.0 4.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 ETS60332.1 - 0.11 13.0 0.4 21 5.6 0.8 2.3 2 0 0 2 2 2 0 AAA domain Cutinase PF01083.22 ETS60334.1 - 3.3e-27 95.6 1.6 7.5e-27 94.4 1.6 1.6 1 1 0 1 1 1 1 Cutinase PE-PPE PF08237.11 ETS60334.1 - 0.033 13.7 0.1 0.059 12.9 0.1 1.4 1 1 0 1 1 1 0 PE-PPE domain Sporozoite_P67 PF05642.11 ETS60334.1 - 1.9 6.5 17.0 2.7 6.0 17.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Consortin_C PF15281.6 ETS60335.1 - 0.22 11.6 0.1 0.22 11.6 0.1 1.8 2 0 0 2 2 2 0 Consortin C-terminus UDPG_MGDP_dh PF00984.19 ETS60336.1 - 8.8e-21 73.9 0.1 5.7e-20 71.3 0.0 2.4 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 ETS60336.1 - 3e-16 59.5 0.1 1.5e-14 54.0 0.0 2.7 2 1 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 ETS60336.1 - 3.3e-05 24.5 0.1 0.00046 20.8 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain UDPG_MGDP_dh_C PF03720.15 ETS60336.1 - 8.2e-05 23.0 0.1 0.00043 20.7 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Epimerase PF01370.21 ETS60336.1 - 0.00081 18.9 0.0 0.12 11.9 0.0 3.0 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 ETS60336.1 - 0.001 19.2 0.0 0.0031 17.7 0.0 1.8 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase TrkA_N PF02254.18 ETS60336.1 - 0.0012 19.1 0.0 0.0043 17.3 0.0 2.0 1 0 0 1 1 1 1 TrkA-N domain Methyltransf_11 PF08241.12 ETS60336.1 - 0.0014 19.2 0.7 0.048 14.3 0.1 3.1 3 0 0 3 3 3 1 Methyltransferase domain GFO_IDH_MocA PF01408.22 ETS60336.1 - 0.031 15.1 0.3 0.17 12.7 0.0 2.4 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Chitin_synth_2 PF03142.15 ETS60337.1 - 1.4e-16 60.2 0.2 1.7e-14 53.4 0.2 2.4 2 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ETS60337.1 - 0.00014 21.9 3.8 0.00031 20.7 3.8 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ETS60337.1 - 0.07 13.0 1.8 1.4 8.8 0.1 2.5 2 1 0 2 2 2 0 Glycosyltransferase like family 2 Iso_dh PF00180.20 ETS60339.1 - 1.1e-72 245.2 0.0 1.2e-72 245.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase G-gamma PF00631.22 ETS60341.1 - 5.7e-23 80.7 0.1 1.8e-22 79.1 0.0 1.9 2 0 0 2 2 2 1 GGL domain F-box-like PF12937.7 ETS60341.1 - 7 6.6 7.9 0.14 12.1 0.5 2.1 2 0 0 2 2 2 0 F-box-like PNP_UDP_1 PF01048.20 ETS60342.1 - 5.7e-39 133.7 1.5 8.4e-39 133.2 1.5 1.3 1 1 0 1 1 1 1 Phosphorylase superfamily CK_II_beta PF01214.18 ETS60343.1 - 2.2e-81 272.0 0.0 2.8e-81 271.7 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Ras PF00071.22 ETS60345.1 - 3.7e-60 202.2 1.1 4.9e-60 201.8 1.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS60345.1 - 1.7e-37 128.3 0.1 2.9e-37 127.6 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS60345.1 - 4.9e-16 58.7 0.2 6e-16 58.4 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS60345.1 - 5.1e-07 29.4 0.4 2.9e-06 27.0 0.4 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETS60345.1 - 5e-06 26.1 0.1 7.5e-06 25.5 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETS60345.1 - 8.2e-06 25.8 0.1 0.012 15.6 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ETS60345.1 - 2.5e-05 24.3 0.1 5.3e-05 23.3 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETS60345.1 - 2.8e-05 23.6 0.4 3.6e-05 23.2 0.4 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FlgH PF02107.16 ETS60345.1 - 0.01 15.4 1.0 0.015 14.9 1.0 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein FeoB_N PF02421.18 ETS60345.1 - 0.025 14.1 0.4 0.68 9.4 0.4 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_28 PF13521.6 ETS60345.1 - 0.031 14.5 0.1 2.2 8.5 0.1 2.2 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ETS60345.1 - 0.042 13.3 0.1 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein DUF2514 PF10721.9 ETS60345.1 - 0.073 13.1 2.4 0.1 12.7 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Dynamin_N PF00350.23 ETS60345.1 - 0.073 13.1 0.2 9.6 6.2 0.0 2.8 2 1 0 2 2 2 0 Dynamin family TetR_C_16 PF17920.1 ETS60345.1 - 0.076 13.3 0.1 0.26 11.5 0.0 1.8 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Cellulase PF00150.18 ETS60346.1 - 3.2e-17 62.9 4.6 4.8e-17 62.3 4.6 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ThiF PF00899.21 ETS60347.1 - 2.3e-66 223.6 0.0 3.3e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 ETS60347.1 - 3.7e-25 87.9 0.0 6e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 ETS60347.1 - 0.016 15.3 0.3 0.03 14.4 0.0 1.5 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 ETS60347.1 - 0.017 14.7 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Prim_Zn_Ribbon PF08273.12 ETS60347.1 - 0.11 12.8 0.3 0.28 11.5 0.3 1.7 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase ApbA PF02558.16 ETS60347.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PglD_N PF17836.1 ETS60347.1 - 0.13 12.9 0.2 0.38 11.4 0.2 1.8 1 0 0 1 1 1 0 PglD N-terminal domain UBA_e1_thiolCys PF10585.9 ETS60347.1 - 0.19 11.6 0.1 13 5.6 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-activating enzyme active site Abhydrolase_6 PF12697.7 ETS60348.1 - 0.0041 17.7 9.6 0.0041 17.7 9.6 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Nup188 PF10487.9 ETS60349.1 - 2.4e-33 115.2 0.0 1.4e-18 66.3 0.0 2.5 2 0 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 ETS60349.1 - 0.0015 17.5 0.4 0.0032 16.3 0.4 1.5 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain ARTD15_N PF18084.1 ETS60349.1 - 0.093 13.0 1.4 1.9 8.8 0.1 3.3 3 0 0 3 3 3 0 ARTD15 N-terminal domain p47_phox_C PF08944.11 ETS60350.1 - 0.41 10.1 11.3 1.7 8.1 1.3 2.5 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain Nuc_sug_transp PF04142.15 ETS60352.1 - 1.1e-80 271.1 12.3 5.5e-70 236.0 9.6 2.9 2 1 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 ETS60352.1 - 5.6e-06 25.8 13.2 0.00033 20.0 0.6 2.5 2 1 0 2 2 2 2 UAA transporter family EamA PF00892.20 ETS60352.1 - 0.0017 18.5 2.1 0.0017 18.5 2.1 3.0 3 0 0 3 3 3 1 EamA-like transporter family TPT PF03151.16 ETS60352.1 - 0.18 11.1 9.6 0.47 9.7 0.3 2.4 2 0 0 2 2 2 0 Triose-phosphate Transporter family DUF202 PF02656.15 ETS60352.1 - 0.96 9.9 0.0 0.96 9.9 0.0 4.0 4 1 0 4 4 4 0 Domain of unknown function (DUF202) CRT-like PF08627.10 ETS60352.1 - 1.4 7.8 8.8 0.59 9.0 1.0 2.6 3 0 0 3 3 3 0 CRT-like, chloroquine-resistance transporter-like DUF2417 PF10329.9 ETS60353.1 - 2e-16 60.2 0.0 3.2e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Cytochrom_B561 PF03188.16 ETS60353.1 - 0.043 13.9 1.6 0.14 12.3 1.6 1.8 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 DUF1270 PF06900.11 ETS60353.1 - 0.45 10.9 3.8 1.2 9.6 3.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1270) RRM_1 PF00076.22 ETS60354.1 - 1.7e-11 43.7 0.0 3.1e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GREB1 PF15782.5 ETS60354.1 - 6.7 3.7 5.6 7.9 3.5 5.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SPC25 PF06703.11 ETS60355.1 - 2e-44 151.3 0.0 2.3e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) Glyco_transf_22 PF03901.17 ETS60356.1 - 5.8e-66 223.4 17.3 2.1e-64 218.3 15.9 2.1 2 0 0 2 2 2 2 Alg9-like mannosyltransferase family AAA PF00004.29 ETS60357.1 - 1.3e-14 54.7 0.0 3.2e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETS60357.1 - 4.2e-11 43.5 0.0 9.9e-10 39.1 0.0 2.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETS60357.1 - 2e-07 31.4 0.0 4.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_lid_10 PF17872.1 ETS60357.1 - 5.1e-06 26.5 0.2 1.3e-05 25.3 0.2 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_19 PF13245.6 ETS60357.1 - 0.00059 20.2 0.1 0.0045 17.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain Cdc6_C PF09079.11 ETS60357.1 - 0.0022 17.9 0.1 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain PIF1 PF05970.14 ETS60357.1 - 0.011 14.9 0.0 0.091 11.9 0.0 2.0 2 0 0 2 2 2 0 PIF1-like helicase AAA_11 PF13086.6 ETS60357.1 - 0.021 14.6 0.0 0.047 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETS60357.1 - 0.029 14.1 0.2 0.058 13.1 0.2 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETS60357.1 - 0.06 13.3 0.0 0.17 11.8 0.0 1.7 1 1 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.18 ETS60357.1 - 0.084 12.6 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase BCDHK_Adom3 PF10436.9 ETS60358.1 - 4.5e-44 150.1 0.0 6.4e-44 149.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ETS60358.1 - 9.8e-09 35.7 0.0 6.3e-08 33.1 0.0 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETS60358.1 - 8.2e-06 25.7 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Gpr1_Fun34_YaaH PF01184.19 ETS60359.1 - 1.8e-70 236.8 20.9 2.2e-70 236.5 20.9 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Pyridoxal_deC PF00282.19 ETS60360.1 - 2e-94 316.4 0.0 1.2e-59 202.0 0.0 2.1 1 1 0 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain Gpr1_Fun34_YaaH PF01184.19 ETS60360.1 - 4.2e-36 124.5 17.9 7.5e-36 123.7 17.9 1.3 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Aminotran_1_2 PF00155.21 ETS60360.1 - 0.0023 17.2 0.0 1 8.5 0.0 2.7 3 0 0 3 3 3 2 Aminotransferase class I and II NIPSNAP PF07978.13 ETS60361.1 - 1.2e-40 137.9 2.1 4.2e-29 100.8 0.2 2.3 2 0 0 2 2 2 2 NIPSNAP Pribosyltran_N PF13793.6 ETS60362.1 - 1.2e-44 150.9 0.1 3e-44 149.7 0.1 1.7 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ETS60362.1 - 2.9e-38 131.8 6.5 2.1e-32 112.6 0.2 2.9 3 1 1 4 4 4 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ETS60362.1 - 3.3e-14 52.7 0.6 1.7e-13 50.4 0.3 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain DUF2007 PF09413.10 ETS60362.1 - 0.075 13.2 0.0 0.24 11.6 0.0 1.9 1 0 0 1 1 1 0 Putative prokaryotic signal transducing protein FAD_binding_7 PF03441.14 ETS60363.1 - 1.3e-73 246.8 0.8 1.9e-73 246.2 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 ETS60363.1 - 9e-44 149.4 0.0 1.7e-43 148.4 0.0 1.4 1 0 0 1 1 1 1 DNA photolyase Glyco_hydro_17 PF00332.18 ETS60364.1 - 2.1e-06 27.6 0.6 4.6e-06 26.5 0.3 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 DUF1043 PF06295.12 ETS60364.1 - 0.036 14.1 3.4 0.89 9.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF3172 PF11371.8 ETS60364.1 - 0.089 12.5 0.6 0.17 11.6 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) Gypsy PF07253.11 ETS60364.1 - 0.089 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Gypsy protein Insulin_TMD PF17870.1 ETS60364.1 - 0.11 12.6 0.8 0.22 11.6 0.8 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment FtsX PF02687.21 ETS60364.1 - 0.11 12.9 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 FtsX-like permease family Zip PF02535.22 ETS60364.1 - 0.13 11.5 0.3 0.2 10.8 0.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sigma_reg_N PF13800.6 ETS60364.1 - 0.13 12.5 0.1 0.37 11.1 0.1 1.7 1 0 0 1 1 1 0 Sigma factor regulator N-terminal ETRAMP PF09716.10 ETS60364.1 - 0.17 12.0 0.8 0.55 10.3 1.0 1.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ODV-E18 PF10717.9 ETS60364.1 - 0.33 10.8 1.5 0.7 9.8 1.5 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 EphA2_TM PF14575.6 ETS60364.1 - 0.89 10.5 0.0 0.89 10.5 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Flp1_like PF16982.5 ETS60364.1 - 2.4 7.6 7.5 4.4 6.8 7.5 1.3 1 0 0 1 1 1 0 Putative Flagellin, Flp1-like, domain SecE PF00584.20 ETS60364.1 - 6.5 6.8 8.8 0.81 9.7 4.2 1.8 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex Glyco_hydro_76 PF03663.14 ETS60365.1 - 4.1e-46 158.2 8.4 4.9e-46 157.9 8.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 ETS60365.1 - 0.00038 19.6 2.1 0.04 13.0 0.0 2.8 2 1 0 2 2 2 2 Glycosyl Hydrolase Family 88 Sda PF08970.10 ETS60365.1 - 0.1 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Sporulation inhibitor A Sugar_tr PF00083.24 ETS60367.1 - 3.6e-111 372.2 18.9 5.6e-111 371.6 18.9 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS60367.1 - 1.8e-29 102.8 74.4 4e-25 88.5 39.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Orai-1 PF07856.12 ETS60367.1 - 0.032 13.9 2.4 0.69 9.6 0.3 2.5 2 0 0 2 2 2 0 Mediator of CRAC channel activity TNFR_16_TM PF18422.1 ETS60367.1 - 5.4 7.1 6.6 21 5.2 0.1 2.9 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain Glyco_hydro_3_C PF01915.22 ETS60369.1 - 6.1e-43 147.1 0.0 1.2e-42 146.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ETS60369.1 - 7.5e-35 120.8 0.0 9.6e-34 117.2 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ETS60369.1 - 1.2e-24 86.2 0.3 2.4e-24 85.2 0.3 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain OTU PF02338.19 ETS60370.1 - 0.00031 21.2 0.0 0.0005 20.6 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_2 PF12756.7 ETS60370.1 - 0.14 12.5 0.0 0.24 11.8 0.0 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) COesterase PF00135.28 ETS60371.1 - 4e-86 289.9 0.0 5e-86 289.6 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS60371.1 - 1.9e-10 41.0 2.3 0.00037 20.4 0.4 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 ETS60371.1 - 0.1 11.5 0.8 0.73 8.7 0.8 2.1 1 1 0 1 1 1 0 Chlorophyllase enzyme Pyrophosphatase PF00719.19 ETS60372.1 - 6.3e-59 198.3 0.3 8.5e-59 197.9 0.3 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Methyltr_RsmB-F PF01189.17 ETS60373.1 - 9.8e-16 58.0 0.1 7.1e-15 55.2 0.1 2.3 2 1 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Cathelicidins PF00666.17 ETS60373.1 - 0.08 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Cathelicidin Cpn60_TCP1 PF00118.24 ETS60375.1 - 2.7e-165 550.7 3.5 3.1e-165 550.5 3.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MTHFR PF02219.17 ETS60376.1 - 6.5e-103 344.0 0.0 2e-84 283.3 0.0 2.1 1 1 1 2 2 2 2 Methylenetetrahydrofolate reductase pPIWI_RE_REase PF18154.1 ETS60376.1 - 0.013 15.4 0.0 0.057 13.4 0.0 2.0 2 0 0 2 2 2 0 REase associating with pPIWI_RE Pyridoxal_deC PF00282.19 ETS60378.1 - 2.3e-66 224.0 0.0 3e-66 223.7 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ETS60378.1 - 0.0091 15.0 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DUF1708 PF08101.11 ETS60379.1 - 2.9e-16 59.7 0.0 8.7e-12 44.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF1708) RhoGAP PF00620.27 ETS60379.1 - 1.9e-06 27.8 0.0 0.00067 19.5 0.0 2.5 2 0 0 2 2 2 2 RhoGAP domain NatB_MDM20 PF09797.9 ETS60380.1 - 4.9e-99 331.9 0.7 8.5e-99 331.1 0.1 1.7 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit BTAD PF03704.17 ETS60380.1 - 0.0015 19.0 0.5 0.0015 19.0 0.5 5.1 5 1 0 5 5 5 1 Bacterial transcriptional activator domain TPR_19 PF14559.6 ETS60380.1 - 0.0046 17.4 4.5 4.5 7.8 0.3 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_5 PF12688.7 ETS60380.1 - 0.0077 16.5 0.3 0.0077 16.5 0.3 4.8 6 1 0 6 6 6 1 Tetratrico peptide repeat ANAPC3 PF12895.7 ETS60380.1 - 0.024 14.8 0.8 15 5.9 0.0 3.7 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 GP40 PF11025.8 ETS60380.1 - 0.085 12.6 0.2 0.42 10.3 0.0 2.1 2 0 0 2 2 2 0 Glycoprotein GP40 of Cryptosporidium AIM5 PF17050.5 ETS60381.1 - 6.2e-08 33.3 0.4 1e-07 32.6 0.4 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 Acyltransferase PF01553.21 ETS60382.1 - 2.3e-22 79.1 0.0 3.8e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 ETS60382.1 - 9.3e-06 25.7 0.0 1.9e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus PrpF PF04303.13 ETS60383.1 - 2.2e-52 178.3 0.1 4.2e-37 128.0 0.0 2.5 2 1 0 2 2 2 2 PrpF protein GDP_Man_Dehyd PF16363.5 ETS60384.1 - 3e-43 148.5 0.0 3.5e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETS60384.1 - 4e-42 144.3 0.0 5e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS60384.1 - 2.4e-11 43.2 0.0 1.5e-10 40.6 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETS60384.1 - 5e-10 38.9 0.0 9.6e-10 38.0 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ETS60384.1 - 4.3e-07 29.4 0.0 3.4e-06 26.4 0.0 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ETS60384.1 - 2.8e-05 23.4 0.0 6.7e-05 22.2 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ETS60384.1 - 0.00018 21.5 0.0 0.0006 19.7 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 ETS60384.1 - 0.00026 21.0 0.0 0.00065 19.7 0.0 1.6 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ETS60384.1 - 0.045 13.6 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short PF00106.25 ETS60384.1 - 0.057 12.9 0.0 0.27 10.7 0.0 1.9 1 1 0 1 1 1 0 short chain dehydrogenase LIM PF00412.22 ETS60385.1 - 3.3e-14 52.8 28.5 9.5e-06 25.8 0.6 6.4 6 0 0 6 6 6 5 LIM domain Vps39_2 PF10367.9 ETS60385.1 - 4.7 7.7 9.6 57 4.2 0.6 4.1 3 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 2 Ribosomal_L10 PF00466.20 ETS60386.1 - 7e-25 87.1 0.0 1.6e-24 85.9 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 ETS60386.1 - 3.1e-21 75.7 9.4 1.1e-20 74.0 8.6 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein RL10P_insert PF17777.1 ETS60386.1 - 3.5e-21 75.0 0.0 5.8e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P RRM_5 PF13893.6 ETS60387.1 - 0.098 12.3 0.0 0.74 9.4 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TAP42 PF04177.12 ETS60388.1 - 9.5e-78 261.5 0.0 1.1e-77 261.3 0.0 1.0 1 0 0 1 1 1 1 TAP42-like family RCDG1 PF15725.5 ETS60388.1 - 4 7.9 10.8 1.3 9.5 5.1 2.7 3 0 0 3 3 3 0 Renal cancer differentiation gene 1 protein Aldo_ket_red PF00248.21 ETS60389.1 - 7e-35 120.6 0.2 1.5e-34 119.6 0.2 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family YflT PF11181.8 ETS60389.1 - 0.015 15.8 0.3 0.083 13.4 0.0 2.4 3 1 0 3 3 3 0 Heat induced stress protein YflT DUF3128 PF11326.8 ETS60390.1 - 0.0011 19.3 0.4 0.0017 18.7 0.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Ndufs5 PF10200.9 ETS60390.1 - 0.0092 16.2 0.6 0.013 15.7 0.6 1.4 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa PADR1 PF08063.12 ETS60390.1 - 0.015 15.1 0.2 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 PADR1 (NUC008) domain Cmc1 PF08583.10 ETS60390.1 - 0.015 15.3 0.6 0.026 14.5 0.6 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like Glyco_hydro_92 PF07971.12 ETS60391.1 - 1.7e-113 380.0 0.0 2.1e-113 379.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 ETS60391.1 - 1.9e-28 100.0 0.0 3.4e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Seipin PF06775.14 ETS60392.1 - 1.4e-49 168.9 0.0 2.5e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) DUF2722 PF10846.8 ETS60392.1 - 4.5e-06 25.9 1.4 4.5e-06 25.9 1.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Suf PF05843.14 ETS60392.1 - 0.84 9.6 8.3 1.5 8.7 8.3 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) FTZ PF03867.14 ETS60392.1 - 2.3 7.7 8.4 4.5 6.7 8.4 1.4 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region CTNNB1_binding PF08347.11 ETS60392.1 - 2.7 8.1 11.2 4.5 7.4 1.6 2.4 2 0 0 2 2 2 0 N-terminal CTNNB1 binding TERB2 PF15101.6 ETS60392.1 - 3 7.9 12.5 6.8 6.7 12.5 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Spt20 PF12090.8 ETS60392.1 - 4.4 6.8 27.3 7.8 6.0 27.3 1.3 1 0 0 1 1 1 0 Spt20 family Peptidase_S49_N PF08496.10 ETS60392.1 - 5.6 7.0 6.7 10 6.1 6.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Flavin_Reduct PF01613.18 ETS60394.1 - 4.5e-33 114.5 0.2 7.4e-33 113.8 0.2 1.3 1 0 0 1 1 1 1 Flavin reductase like domain Amidohydro_1 PF01979.20 ETS60395.1 - 4.9e-62 210.2 0.2 9e-62 209.4 0.2 1.4 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ETS60395.1 - 1.1e-56 190.3 0.4 2.3e-56 189.3 0.4 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_gamma PF00547.18 ETS60395.1 - 3.9e-41 139.4 0.3 9.9e-41 138.1 0.3 1.7 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 ETS60395.1 - 2.5e-33 114.0 0.0 5.6e-33 112.9 0.0 1.6 2 0 0 2 2 2 1 Urease beta subunit Amidohydro_3 PF07969.11 ETS60395.1 - 7e-06 25.8 0.2 0.00015 21.4 0.0 3.0 3 1 0 3 3 3 1 Amidohydrolase family Amidase PF01425.21 ETS60397.1 - 4.1e-44 151.3 0.1 2.3e-41 142.2 0.1 2.1 2 0 0 2 2 2 2 Amidase DUF5427 PF10310.9 ETS60397.1 - 0.069 12.1 0.0 0.1 11.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DIOX_N PF14226.6 ETS60398.1 - 1.4e-12 48.4 0.0 3.6e-12 47.1 0.0 1.6 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETS60398.1 - 2.9e-12 47.0 0.0 1.2e-11 45.0 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Methyltransf_25 PF13649.6 ETS60399.1 - 0.017 15.8 0.1 2.2 9.0 0.0 2.9 3 0 0 3 3 3 0 Methyltransferase domain YL1 PF05764.13 ETS60400.1 - 7.7e-51 173.6 23.9 7.7e-51 173.6 23.9 3.1 3 0 0 3 3 3 2 YL1 nuclear protein YL1_C PF08265.11 ETS60400.1 - 6.4e-14 51.4 1.0 1.1e-13 50.7 1.0 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain cwf18 PF08315.12 ETS60401.1 - 4e-28 98.8 9.1 7e-28 98.0 9.1 1.4 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor GATase_6 PF13522.6 ETS60402.1 - 3.4e-14 53.2 0.0 8.9e-14 51.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ETS60402.1 - 2.2e-10 40.5 0.0 4.5e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 ETS60402.1 - 7.2e-10 38.6 0.1 1.7e-09 37.4 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 ETS60402.1 - 5.3e-06 25.5 0.0 1e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Peptidase_M24 PF00557.24 ETS60403.1 - 1.9e-39 135.5 0.3 2.7e-39 135.1 0.3 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 TFIIF_alpha PF05793.12 ETS60403.1 - 0.0027 16.4 11.1 0.0037 15.9 11.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) YL1 PF05764.13 ETS60403.1 - 0.0046 17.1 9.7 0.0072 16.5 9.7 1.3 1 0 0 1 1 1 1 YL1 nuclear protein Drc1-Sld2 PF11719.8 ETS60403.1 - 0.034 13.7 8.1 0.045 13.3 8.1 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein SDA1 PF05285.12 ETS60403.1 - 0.037 13.5 10.2 0.051 13.0 10.2 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETS60403.1 - 0.19 10.0 8.0 0.26 9.5 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETS60403.1 - 0.29 9.3 9.7 0.42 8.8 9.7 1.1 1 0 0 1 1 1 0 Nop14-like family CCDC106 PF15794.5 ETS60403.1 - 0.41 10.3 4.2 0.84 9.3 4.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF4604 PF15377.6 ETS60403.1 - 0.62 10.5 15.2 1.2 9.5 15.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) RNA_pol_Rpc4 PF05132.14 ETS60403.1 - 0.97 9.9 5.1 1.7 9.1 5.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 CENP-B_dimeris PF09026.10 ETS60403.1 - 1.6 9.1 14.1 3.6 8.1 14.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF913 PF06025.12 ETS60403.1 - 1.7 7.6 3.2 2.8 6.8 3.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3381 PF11861.8 ETS60403.1 - 3.3 7.5 12.1 0.13 12.1 6.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) PGA2 PF07543.12 ETS60403.1 - 5.7 6.9 12.9 0.23 11.4 6.0 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 PBP1_TM PF14812.6 ETS60403.1 - 8.3 6.9 18.8 0.18 12.2 11.0 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Macro PF01661.21 ETS60404.1 - 1.3e-41 141.3 0.1 2.1e-41 140.7 0.1 1.3 1 0 0 1 1 1 1 Macro domain DUF1955 PF09205.10 ETS60404.1 - 0.17 11.6 0.0 0.4 10.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1955) Romo1 PF10247.9 ETS60405.1 - 1.7e-24 85.9 11.7 2.8e-24 85.3 11.7 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 zf-HC5HC2H_2 PF13832.6 ETS60406.1 - 6.3e-33 113.2 6.3 6.3e-33 113.2 6.3 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 ETS60406.1 - 7.3e-25 88.2 0.1 7.3e-25 88.2 0.1 3.6 4 1 0 4 4 4 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 ETS60406.1 - 3.7e-24 84.8 4.0 3.7e-24 84.8 4.0 2.9 3 0 0 3 3 3 1 PHD-like zinc-binding domain Bromodomain PF00439.25 ETS60406.1 - 6.1e-19 67.9 0.3 1.1e-18 67.0 0.3 1.5 1 0 0 1 1 1 1 Bromodomain PHD_2 PF13831.6 ETS60406.1 - 1.1e-14 53.7 2.6 1.1e-14 53.7 2.6 2.6 2 0 0 2 2 2 1 PHD-finger PWWP PF00855.17 ETS60406.1 - 1.5e-11 44.5 2.1 1.7e-11 44.4 0.2 2.2 2 0 0 2 2 2 1 PWWP domain PHD PF00628.29 ETS60406.1 - 5.5e-11 42.2 5.7 5.5e-11 42.2 5.7 2.7 2 0 0 2 2 2 1 PHD-finger zf-PHD-like PF15446.6 ETS60406.1 - 0.0032 17.1 0.7 0.0032 17.1 0.7 2.8 3 0 0 3 3 3 1 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 ETS60406.1 - 0.013 15.3 0.4 0.013 15.3 0.4 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 ETS60406.1 - 0.05 13.9 14.5 0.1 13.0 5.7 2.5 2 0 0 2 2 2 0 RING-like domain Prok-RING_1 PF14446.6 ETS60406.1 - 0.68 9.9 17.1 0.043 13.7 3.0 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Use1 PF09753.9 ETS60407.1 - 1.6e-12 47.7 0.0 3.8e-12 46.5 0.0 1.6 2 0 0 2 2 2 1 Membrane fusion protein Use1 SNARE PF05739.19 ETS60407.1 - 0.23 11.5 2.0 0.53 10.3 0.1 2.4 2 2 0 2 2 2 0 SNARE domain K_channel_TID PF07941.11 ETS60407.1 - 6.6 7.3 12.3 0.095 13.2 3.9 2.2 3 0 0 3 3 3 0 Potassium channel Kv1.4 tandem inactivation domain tRNA-synt_His PF13393.6 ETS60408.1 - 2.9e-41 141.8 0.2 4.2e-35 121.5 0.0 3.0 3 0 0 3 3 3 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ETS60408.1 - 6.6e-09 35.8 0.3 2e-08 34.2 0.0 2.0 2 0 0 2 2 2 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 ETS60408.1 - 1.5e-07 31.2 0.7 2.8e-07 30.3 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs APG6_N PF17675.1 ETS60408.1 - 0.012 16.2 2.5 0.025 15.1 2.5 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region tRNA-synt_2 PF00152.20 ETS60408.1 - 0.1 11.7 0.3 1.7 7.7 0.1 2.6 2 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) PORR PF11955.8 ETS60408.1 - 0.14 11.1 0.0 0.33 9.9 0.0 1.5 2 0 0 2 2 2 0 Plant organelle RNA recognition domain Ribosomal_60s PF00428.19 ETS60408.1 - 2.5 8.8 9.0 0.11 13.1 2.3 2.3 2 0 0 2 2 2 0 60s Acidic ribosomal protein WHEP-TRS PF00458.20 ETS60408.1 - 7.2 6.8 9.8 1.1 9.5 4.9 2.3 2 0 0 2 2 2 0 WHEP-TRS domain ubiquitin PF00240.23 ETS60409.1 - 7.3e-26 89.7 0.4 8.1e-26 89.6 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETS60409.1 - 1.9e-15 56.4 0.4 2.1e-15 56.3 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETS60409.1 - 0.00016 22.0 0.1 0.00047 20.6 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETS60409.1 - 0.00055 19.8 0.0 0.00065 19.6 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ETS60409.1 - 0.03 14.7 0.2 0.032 14.6 0.2 1.1 1 0 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ETS60409.1 - 0.11 12.6 0.6 3.5 7.8 0.6 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain HMG_box PF00505.19 ETS60410.1 - 1.5e-09 38.2 4.1 1.1e-08 35.4 4.1 2.2 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS60410.1 - 0.013 16.1 1.3 0.025 15.1 1.3 1.5 1 0 0 1 1 1 0 HMG-box domain RibD_C PF01872.17 ETS60411.1 - 1.1e-32 113.5 0.1 1.3e-32 113.2 0.1 1.1 1 0 0 1 1 1 1 RibD C-terminal domain DAGK_cat PF00781.24 ETS60412.1 - 7.8e-24 83.7 0.0 1.3e-23 82.9 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain adh_short PF00106.25 ETS60413.1 - 7.8e-23 80.9 0.0 2.4e-22 79.4 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60413.1 - 2e-17 63.6 0.1 3.1e-17 62.9 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 ETS60413.1 - 0.0011 18.4 0.0 0.0017 17.8 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) KR PF08659.10 ETS60413.1 - 0.0016 18.4 0.7 0.0065 16.4 0.7 2.2 1 1 0 1 1 1 1 KR domain FAD_binding_3 PF01494.19 ETS60413.1 - 0.048 12.9 0.1 0.059 12.6 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 ETS60413.1 - 0.067 12.8 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 ETS60413.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NmrA PF05368.13 ETS60413.1 - 0.2 11.2 0.7 0.35 10.4 0.0 1.7 2 0 0 2 2 2 0 NmrA-like family Pkinase PF00069.25 ETS60414.1 - 2.1e-69 233.9 0.0 2.5e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60414.1 - 2.9e-36 125.1 0.0 3.7e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS60414.1 - 1.3e-09 37.8 0.0 1.9e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETS60414.1 - 1.1e-06 27.8 0.5 1.6e-06 27.2 0.1 1.4 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETS60414.1 - 1.2e-05 24.8 0.1 2.8e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETS60414.1 - 0.0011 18.5 0.0 0.0022 17.6 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 ETS60414.1 - 0.003 17.5 0.0 0.0079 16.1 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family TetR_C_27 PF17935.1 ETS60414.1 - 0.024 14.7 0.0 0.064 13.3 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain zf-RING_2 PF13639.6 ETS60415.1 - 4.4e-11 42.9 9.9 6.8e-11 42.3 9.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETS60415.1 - 1.3e-08 34.9 7.9 2.6e-08 34.0 7.9 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ETS60415.1 - 5.4e-07 29.2 3.1 9.8e-07 28.4 3.1 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 ETS60415.1 - 1.9e-06 27.8 3.6 4.2e-06 26.7 3.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ETS60415.1 - 5.6e-06 26.1 8.8 9.2e-06 25.4 8.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS60415.1 - 6.1e-06 26.0 7.7 9.8e-06 25.3 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS60415.1 - 6.5e-05 22.8 7.1 0.0001 22.2 7.1 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ETS60415.1 - 0.00096 19.0 7.1 0.0016 18.3 7.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS60415.1 - 0.0024 17.7 5.7 0.0042 16.9 5.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 ETS60415.1 - 0.0048 17.2 9.0 0.0075 16.6 9.0 1.3 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H PF13771.6 ETS60415.1 - 0.032 14.5 3.5 0.072 13.3 3.5 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ETS60415.1 - 0.11 12.7 3.2 0.22 11.7 3.2 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_4 PF14570.6 ETS60415.1 - 0.4 10.5 7.0 0.84 9.5 7.0 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_5 PF17121.5 ETS60415.1 - 0.6 10.0 3.5 1.1 9.1 3.5 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS60415.1 - 0.64 10.1 6.3 1.3 9.1 6.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3H2C3 PF17122.5 ETS60415.1 - 0.83 9.7 2.0 1.5 8.9 2.0 1.4 1 0 0 1 1 1 0 Zinc-finger Zn_ribbon_17 PF17120.5 ETS60415.1 - 1.5 8.5 7.6 2.6 7.7 7.6 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ETS60415.1 - 5.7 7.2 11.0 10 6.3 11.0 1.4 1 0 0 1 1 1 0 RING-variant domain PHD PF00628.29 ETS60415.1 - 7.4 6.5 8.7 12 5.8 8.7 1.4 1 0 0 1 1 1 0 PHD-finger NCE101 PF11654.8 ETS60416.1 - 9.1e-19 66.9 0.1 1.3e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 Non-classical export protein 1 RhoGEF PF00621.20 ETS60417.1 - 6.1e-36 124.4 0.1 1.2e-35 123.4 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain SH3_1 PF00018.28 ETS60417.1 - 1.9e-18 65.8 1.0 7.2e-09 35.1 0.2 2.5 2 0 0 2 2 2 2 SH3 domain EF-hand_4 PF12763.7 ETS60417.1 - 3.7e-16 59.0 0.0 1e-15 57.5 0.0 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand SH3_9 PF14604.6 ETS60417.1 - 1.1e-12 47.6 1.4 3.6e-08 33.1 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ETS60417.1 - 2.1e-09 36.9 0.0 3.7e-05 23.3 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain WH2 PF02205.20 ETS60417.1 - 2.8e-09 36.5 0.7 8.6e-09 34.9 0.7 1.9 1 0 0 1 1 1 1 WH2 motif SH3_10 PF17902.1 ETS60417.1 - 0.0063 16.6 0.0 0.018 15.1 0.0 1.8 1 0 0 1 1 1 1 SH3 domain EF-hand_1 PF00036.32 ETS60417.1 - 0.016 14.7 0.9 1.9 8.2 0.0 2.9 3 0 0 3 3 3 0 EF hand EF-hand_7 PF13499.6 ETS60417.1 - 0.024 15.1 0.0 0.085 13.3 0.0 2.0 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETS60417.1 - 0.14 12.2 0.0 36 4.6 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain PH_13 PF16652.5 ETS60417.1 - 1.5 8.6 6.5 1 9.2 0.1 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain C_Hendra PF16821.5 ETS60418.1 - 0.26 11.2 2.8 0.53 10.1 0.7 2.2 2 0 0 2 2 2 0 C protein from hendra and measles viruses AA_permease PF00324.21 ETS60419.1 - 2.7e-128 428.6 43.7 3.4e-128 428.3 43.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS60419.1 - 8.1e-38 130.3 46.5 1.1e-37 129.9 46.5 1.1 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L23eN PF03939.13 ETS60420.1 - 1.8e-21 76.1 11.1 4.2e-21 74.9 11.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 ETS60420.1 - 2.8e-13 50.0 0.1 8.5e-13 48.5 0.1 1.8 1 0 0 1 1 1 1 Ribosomal protein L23 WD40 PF00400.32 ETS60421.1 - 0.00018 22.2 0.6 0.31 12.0 0.1 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat Pkinase PF00069.25 ETS60422.1 - 3.3e-17 62.7 0.0 9.4e-12 44.8 0.0 5.2 4 1 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60422.1 - 1.1e-06 28.2 0.0 7e-05 22.2 0.0 2.8 3 1 0 3 3 3 2 Protein tyrosine kinase YABBY PF04690.13 ETS60423.1 - 1.7e-08 35.2 0.2 3.2e-08 34.3 0.2 1.4 1 0 0 1 1 1 1 YABBY protein Ccdc124 PF06244.12 ETS60423.1 - 7.3e-05 23.3 1.3 0.00012 22.7 1.3 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 ETS60423.1 - 0.0038 17.6 1.7 0.0079 16.6 1.7 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS60423.1 - 0.0045 17.5 1.2 0.0091 16.6 1.2 1.5 1 0 0 1 1 1 1 HMG-box domain Rotamase PF00639.21 ETS60424.1 - 8.4e-24 84.4 0.0 1.1e-23 84.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ETS60424.1 - 9.3e-21 74.5 0.0 1.2e-20 74.2 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ETS60424.1 - 4.9e-07 30.6 0.0 6.7e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 ETS60424.1 - 3.1e-06 27.2 1.3 9.8e-06 25.6 0.5 2.1 2 0 0 2 2 2 1 WW domain VPS11_C PF12451.8 ETS60424.1 - 1.4 9.2 3.4 0.63 10.3 0.6 1.8 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal HIT PF01230.23 ETS60425.1 - 6.2e-25 87.8 0.2 9.4e-25 87.2 0.2 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ETS60425.1 - 2e-13 50.8 0.1 2.6e-13 50.4 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ETS60425.1 - 5.2e-05 23.1 0.0 8.2e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 FHA PF00498.26 ETS60426.1 - 9e-08 32.4 0.0 1.7e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 FHA domain CPSase_L_D2 PF02786.17 ETS60427.1 - 2.2e-53 180.9 0.0 4.3e-53 179.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Carboxyl_trans PF01039.22 ETS60427.1 - 2.9e-46 158.1 0.0 8.2e-46 156.7 0.0 1.7 1 1 0 1 1 1 1 Carboxyl transferase domain Biotin_carb_N PF00289.22 ETS60427.1 - 2.1e-33 115.2 0.7 1.4e-32 112.5 0.0 2.8 3 0 0 3 3 3 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ETS60427.1 - 5.8e-21 74.6 0.0 1.5e-20 73.3 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ETS60427.1 - 9.8e-10 38.1 3.1 2.3e-09 36.9 3.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATPgrasp_ST PF14397.6 ETS60427.1 - 0.001 18.4 0.1 0.0048 16.2 0.0 1.9 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Dala_Dala_lig_C PF07478.13 ETS60427.1 - 0.0027 17.3 0.0 0.0059 16.2 0.0 1.5 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 ETS60427.1 - 0.029 14.4 0.0 0.13 12.3 0.0 2.1 2 1 0 2 2 2 0 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ETS60427.1 - 0.029 14.2 6.1 0.31 10.9 0.5 3.0 3 0 0 3 3 3 0 Biotin-lipoyl like HlyD_D23 PF16576.5 ETS60427.1 - 0.1 11.8 1.2 1.4 8.1 0.2 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion SARAF PF06682.12 ETS60428.1 - 4.8e-61 207.2 0.5 7e-61 206.7 0.5 1.2 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis PQ-loop PF04193.14 ETS60429.1 - 2.6e-27 94.3 11.7 1.7e-13 50.1 3.1 2.7 3 0 0 3 3 3 2 PQ loop repeat Comm PF15957.5 ETS60429.1 - 0.013 15.8 0.2 0.035 14.5 0.1 1.8 2 0 0 2 2 2 0 Commissureless ABM PF03992.16 ETS60430.1 - 1.6e-07 31.3 0.0 2e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Aconitase PF00330.20 ETS60431.1 - 1.7e-164 548.2 0.1 2.1e-164 547.9 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ETS60431.1 - 1.2e-42 145.4 0.0 2.2e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Ribosomal_L5 PF00281.19 ETS60431.1 - 0.16 12.3 0.0 0.53 10.7 0.0 1.9 1 0 0 1 1 1 0 Ribosomal protein L5 EF-hand_6 PF13405.6 ETS60433.1 - 2e-09 36.6 0.1 0.0015 18.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETS60433.1 - 1.3e-08 35.1 0.0 4.6e-08 33.4 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETS60433.1 - 1e-07 30.9 0.1 0.0024 17.3 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 ETS60433.1 - 7.3e-07 28.4 0.1 0.00097 18.5 0.0 2.7 2 0 0 2 2 2 2 EF hand RRM_1 PF00076.22 ETS60433.1 - 1.8e-06 27.7 0.0 3.7e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EF-hand_8 PF13833.6 ETS60433.1 - 5.8e-05 22.9 0.1 0.0025 17.6 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair Rbx_binding PF18113.1 ETS60434.1 - 0.097 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain WD40 PF00400.32 ETS60435.1 - 0.00018 22.2 0.1 1.1 10.2 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Ribosomal_S6 PF01250.17 ETS60435.1 - 0.19 12.0 0.0 0.7 10.2 0.0 2.0 1 0 0 1 1 1 0 Ribosomal protein S6 Peptidase_M16 PF00675.20 ETS60436.1 - 8.9e-55 184.8 0.2 2.2e-54 183.5 0.2 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ETS60436.1 - 3.4e-39 134.8 0.0 1e-36 126.6 0.0 2.2 2 0 0 2 2 2 2 Peptidase M16 inactive domain ENTH PF01417.20 ETS60437.1 - 3.4e-44 149.9 0.2 4.9e-44 149.4 0.2 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ETS60437.1 - 6.8e-05 22.0 0.0 9.8e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 ANTH domain Pinin_SDK_N PF04697.13 ETS60437.1 - 0.016 15.8 0.7 0.016 15.8 0.7 2.3 2 1 1 3 3 3 0 pinin/SDK conserved region NB-LRR PF12061.8 ETS60437.1 - 0.17 11.2 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Late blight resistance protein R1 GRP PF07172.11 ETS60437.1 - 0.27 12.0 14.1 0.56 10.9 14.1 1.5 1 0 0 1 1 1 0 Glycine rich protein family DNA_methylase PF00145.17 ETS60438.1 - 1.1e-48 166.3 0.0 2e-48 165.4 0.0 1.4 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Dioxygenase_C PF00775.21 ETS60439.1 - 2.1e-07 30.6 0.2 3.4e-05 23.3 0.0 2.3 1 1 1 2 2 2 2 Dioxygenase Abhydrolase_1 PF00561.20 ETS60440.1 - 4.4e-20 72.4 0.1 6.5e-20 71.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS60440.1 - 3.2e-14 54.1 3.6 3.2e-14 54.1 3.6 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS60440.1 - 3.5e-09 36.3 0.0 6.1e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 CMD PF02627.20 ETS60440.1 - 4.1e-09 36.4 0.3 1.2e-08 34.8 0.3 1.9 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Peptidase_S9 PF00326.21 ETS60440.1 - 3.8e-05 23.3 0.0 0.07 12.6 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 ETS60440.1 - 0.00011 22.0 0.1 0.0002 21.1 0.1 1.4 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 ETS60440.1 - 0.00013 20.8 0.0 0.00046 19.0 0.0 1.9 1 1 0 1 1 1 1 Ndr family Thioesterase PF00975.20 ETS60440.1 - 0.065 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_2 PF02230.16 ETS60440.1 - 0.2 11.4 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Arrestin_N PF00339.29 ETS60441.1 - 0.00025 21.1 0.0 0.002 18.2 0.0 2.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain ELFV_dehydrog PF00208.21 ETS60442.1 - 1.4e-55 188.7 0.0 2e-55 188.1 0.0 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ETS60442.1 - 1.4e-21 75.9 0.0 1.6e-14 52.5 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase Peptidase_M56 PF05569.11 ETS60444.1 - 0.048 12.9 0.0 0.06 12.5 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF3021 PF11457.8 ETS60444.1 - 0.074 13.4 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF347 PF03988.12 ETS60444.1 - 0.091 13.0 0.2 0.17 12.1 0.2 1.4 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Ribosomal_L22 PF00237.19 ETS60445.1 - 1.9e-33 114.7 0.1 3e-33 114.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e PAP_central PF04928.17 ETS60446.1 - 7e-109 362.6 0.0 1.4e-108 361.6 0.0 1.4 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ETS60446.1 - 6.2e-58 195.2 0.3 1.6e-57 193.8 0.0 1.8 2 0 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 ETS60446.1 - 4e-11 43.1 0.0 1.1e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 ETS60446.1 - 0.12 12.1 0.2 0.28 10.9 0.2 1.6 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Abhydrolase_6 PF12697.7 ETS60447.1 - 0.00031 21.4 1.8 0.00061 20.4 0.0 2.4 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.7 ETS60447.1 - 0.0006 19.6 0.0 0.0014 18.4 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS60447.1 - 0.014 14.7 0.0 0.04 13.2 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ETS60447.1 - 0.032 13.2 0.0 0.057 12.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme PGAP1 PF07819.13 ETS60447.1 - 0.06 13.1 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Proteasome PF00227.26 ETS60448.1 - 2.9e-56 190.0 0.6 3.8e-56 189.6 0.6 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ETS60448.1 - 1.5e-13 50.1 0.0 2.8e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature RAG1_imp_bd PF12560.8 ETS60451.1 - 6.1 6.3 11.1 0.72 9.3 7.0 1.5 1 1 1 2 2 2 0 RAG1 importin binding MFS_1 PF07690.16 ETS60452.1 - 2.5e-29 102.3 32.4 2.5e-29 102.3 32.4 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Pinin_SDK_memA PF04696.13 ETS60452.1 - 0.25 11.4 0.1 0.38 10.8 0.1 1.1 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region Zn_clus PF00172.18 ETS60454.1 - 1.1e-06 28.6 8.3 2e-06 27.8 8.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS60454.1 - 0.00019 20.5 0.2 0.00032 19.8 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain BNR_2 PF13088.6 ETS60455.1 - 3.5e-06 26.5 0.1 2.7e-05 23.6 0.1 2.1 1 1 1 2 2 2 1 BNR repeat-like domain BNR PF02012.20 ETS60455.1 - 3.6e-05 23.1 7.4 0.08 13.0 0.3 4.5 3 0 0 3 3 3 2 BNR/Asp-box repeat Sortilin-Vps10 PF15902.5 ETS60455.1 - 0.0017 17.2 0.1 0.57 8.9 0.0 2.3 1 1 1 3 3 3 2 Sortilin, neurotensin receptor 3, BNR_6 PF15899.5 ETS60455.1 - 0.14 12.3 2.0 8.3 6.8 0.1 3.1 2 0 0 2 2 2 0 BNR-Asp box repeat Sugar_tr PF00083.24 ETS60457.1 - 2.5e-103 346.4 24.4 3.2e-103 346.0 24.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS60457.1 - 1.4e-22 80.1 43.7 1.5e-18 66.8 22.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Alpha-L-AF_C PF06964.12 ETS60458.1 - 2.2e-28 99.5 0.0 3.2e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain DUF5325 PF17259.2 ETS60459.1 - 8.9 6.3 20.1 0.18 11.7 1.6 2.8 1 1 1 2 2 2 0 Family of unknown function (DUF5325) SIR2 PF02146.17 ETS60460.1 - 1e-25 90.7 0.2 6.1e-24 84.9 0.2 3.3 1 1 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 ETS60460.1 - 0.0024 17.6 0.1 0.15 11.8 0.0 2.2 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Cellulase PF00150.18 ETS60461.1 - 5e-11 42.5 7.0 1.8e-10 40.7 6.5 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Proteasome PF00227.26 ETS60462.1 - 1.3e-48 165.0 0.2 1.7e-48 164.7 0.2 1.1 1 0 0 1 1 1 1 Proteasome subunit mRNA_cap_enzyme PF01331.19 ETS60463.1 - 1.9e-48 164.9 0.0 2.4e-48 164.6 0.0 1.1 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ETS60463.1 - 7.9e-28 97.2 0.0 1.1e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ETS60463.1 - 0.00026 20.7 0.0 0.015 14.9 0.0 2.2 1 1 0 1 1 1 1 ATP dependent DNA ligase domain ATG7_N PF16420.5 ETS60464.1 - 9.2e-90 301.3 0.0 1.5e-89 300.6 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 ETS60464.1 - 3.6e-45 154.2 0.0 5.4e-45 153.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ETS60464.1 - 0.0068 16.5 0.0 0.067 13.2 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ETS60464.1 - 0.15 11.4 0.0 2.6 7.4 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TFIIS_C PF01096.18 ETS60465.1 - 3.2e-16 58.9 5.8 1.1e-15 57.1 0.4 3.3 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ETS60465.1 - 2.8e-07 30.3 7.8 0.00043 20.1 0.5 3.1 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit TF_Zn_Ribbon PF08271.12 ETS60465.1 - 0.00049 19.6 7.9 0.072 12.6 0.6 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding DZR PF12773.7 ETS60465.1 - 0.00091 19.2 7.1 0.15 12.1 0.3 3.2 2 1 0 2 2 2 2 Double zinc ribbon IBR PF01485.21 ETS60465.1 - 0.0047 17.1 2.2 2.8 8.2 0.4 2.6 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain zf-TFIIB PF13453.6 ETS60465.1 - 0.02 14.2 3.9 0.045 13.1 0.8 2.5 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-RING_7 PF02591.15 ETS60465.1 - 0.029 14.5 3.1 0.42 10.8 0.0 3.6 4 0 0 4 4 3 0 C4-type zinc ribbon domain OrfB_Zn_ribbon PF07282.11 ETS60465.1 - 0.045 13.7 5.0 0.68 9.9 0.1 2.8 2 1 0 2 2 2 0 Putative transposase DNA-binding domain Prok-RING_1 PF14446.6 ETS60465.1 - 0.094 12.7 5.8 1.2 9.2 0.2 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-H2C2_2 PF13465.6 ETS60465.1 - 0.27 11.7 0.1 0.27 11.7 0.1 3.4 4 0 0 4 4 3 0 Zinc-finger double domain NOB1_Zn_bind PF08772.11 ETS60465.1 - 0.3 11.3 6.3 7.3 6.8 0.0 3.5 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.11 ETS60465.1 - 0.38 10.4 9.2 9 6.1 0.1 4.1 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain zf-ribbon_3 PF13248.6 ETS60465.1 - 0.45 10.0 20.4 0.42 10.1 4.3 4.0 3 1 0 3 3 3 0 zinc-ribbon domain zf-ISL3 PF14690.6 ETS60465.1 - 0.84 10.3 7.3 51 4.6 0.1 4.3 4 0 0 4 4 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Mu-like_Com PF10122.9 ETS60465.1 - 0.91 9.0 7.6 29 4.2 1.6 3.9 3 1 0 3 3 3 0 Mu-like prophage protein Com Zn_Tnp_IS1595 PF12760.7 ETS60465.1 - 1.1 9.3 9.6 13 5.9 2.4 3.5 2 2 0 2 2 2 0 Transposase zinc-ribbon domain zinc_ribbon_2 PF13240.6 ETS60465.1 - 1.1 9.1 18.9 2.4 8.0 0.6 3.8 3 1 0 3 3 3 0 zinc-ribbon domain zf_C2H2_10 PF18414.1 ETS60465.1 - 1.4 8.5 5.9 2.4 7.8 0.9 3.1 3 0 0 3 3 3 0 C2H2 type zinc-finger PhnA_Zn_Ribbon PF08274.12 ETS60465.1 - 1.5 8.8 5.9 14 5.7 0.1 3.2 2 1 0 2 2 2 0 PhnA Zinc-Ribbon Nop10p PF04135.12 ETS60465.1 - 1.7 8.8 4.2 3.4 7.8 0.1 3.1 2 1 1 3 3 3 0 Nucleolar RNA-binding protein, Nop10p family CpXC PF14353.6 ETS60465.1 - 2.2 8.4 9.6 12 5.9 0.2 4.2 4 1 1 5 5 4 0 CpXC protein zf-IS66 PF13005.7 ETS60465.1 - 4 7.9 11.1 4.2 7.8 0.0 3.7 4 0 0 4 4 3 0 zinc-finger binding domain of transposase IS66 zinc_ribbon_5 PF13719.6 ETS60465.1 - 4 7.3 8.8 2.4 8.0 0.2 3.3 3 1 0 3 3 3 0 zinc-ribbon domain Ribosomal_S27e PF01667.17 ETS60465.1 - 5.5 6.8 8.7 8.4 6.2 0.0 3.9 3 1 1 4 4 4 0 Ribosomal protein S27 Zn-ribbon_8 PF09723.10 ETS60465.1 - 7.9 6.7 16.4 26 5.0 0.1 4.2 2 2 1 4 4 4 0 Zinc ribbon domain AAA_5 PF07728.14 ETS60466.1 - 9.7e-114 375.5 0.1 1.6e-21 76.7 0.0 9.6 8 1 0 9 9 9 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 ETS60466.1 - 1.8e-46 156.7 1.1 8.5e-15 54.9 0.0 5.6 4 0 0 4 4 4 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 ETS60466.1 - 1.3e-27 96.0 0.0 5e-27 94.1 0.0 2.1 1 0 0 1 1 1 1 Midasin AAA lid domain AAA_3 PF07726.11 ETS60466.1 - 1.2e-23 83.4 0.0 4.9e-06 26.4 0.0 7.1 7 0 0 7 7 6 3 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ETS60466.1 - 3.2e-21 76.1 0.2 0.0055 17.1 0.0 6.9 6 0 0 6 6 6 4 ATPase family associated with various cellular activities (AAA) Dynein_heavy PF03028.15 ETS60466.1 - 5.2e-21 74.9 0.0 0.00013 22.0 0.0 7.2 7 0 0 7 7 6 5 Dynein heavy chain region D6 P-loop domain AAA_7 PF12775.7 ETS60466.1 - 4e-19 68.8 0.3 0.0025 17.4 0.1 7.0 7 0 0 7 7 7 2 P-loop containing dynein motor region AAA_22 PF13401.6 ETS60466.1 - 3.6e-18 66.2 1.0 0.043 14.1 0.0 8.4 8 0 0 8 8 6 3 AAA domain AAA_16 PF13191.6 ETS60466.1 - 2.3e-15 57.4 44.5 0.0059 17.0 0.1 11.3 10 2 0 10 10 8 6 AAA ATPase domain AAA_18 PF13238.6 ETS60466.1 - 6e-15 55.9 0.0 0.12 12.9 0.0 6.7 5 0 0 5 5 5 3 AAA domain AAA_30 PF13604.6 ETS60466.1 - 3.3e-14 53.0 10.3 0.034 13.8 0.1 8.4 8 1 0 8 8 7 3 AAA domain AAA_33 PF13671.6 ETS60466.1 - 5.6e-14 52.5 5.3 0.082 13.1 0.1 7.6 8 0 0 8 8 5 3 AAA domain ABC_tran PF00005.27 ETS60466.1 - 5.9e-14 52.7 0.8 0.17 12.4 0.0 7.0 7 0 0 7 7 6 3 ABC transporter AAA_6 PF12774.7 ETS60466.1 - 7.7e-13 48.1 0.0 0.26 10.2 0.0 7.9 9 0 0 9 9 9 2 Hydrolytic ATP binding site of dynein motor region T2SSE PF00437.20 ETS60466.1 - 1.4e-11 43.9 3.3 0.12 11.4 0.0 6.4 6 0 0 6 6 6 3 Type II/IV secretion system protein TsaE PF02367.17 ETS60466.1 - 1.6e-11 44.3 4.9 0.32 11.0 0.2 6.6 6 0 0 6 6 6 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 ETS60466.1 - 4e-11 43.4 4.3 0.12 12.6 0.0 6.9 6 0 0 6 6 6 3 AAA domain Sigma54_activat PF00158.26 ETS60466.1 - 5.1e-11 42.6 0.0 1.7 8.3 0.0 6.1 6 0 0 6 6 6 3 Sigma-54 interaction domain AAA_29 PF13555.6 ETS60466.1 - 6.7e-11 41.8 2.4 0.12 12.2 0.0 6.1 6 0 0 6 6 6 2 P-loop containing region of AAA domain NACHT PF05729.12 ETS60466.1 - 9.5e-10 38.6 2.6 0.13 12.1 0.0 6.1 5 0 0 5 5 5 1 NACHT domain Mg_chelatase PF01078.21 ETS60466.1 - 1.2e-08 34.6 4.6 0.24 10.8 0.2 6.7 8 0 0 8 8 6 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ETS60466.1 - 1.3e-08 34.7 7.1 0.059 12.9 0.0 6.5 6 0 0 6 6 6 2 AAA domain AAA_14 PF13173.6 ETS60466.1 - 1.5e-08 34.8 0.0 0.021 14.8 0.0 5.8 6 0 0 6 6 5 1 AAA domain Zeta_toxin PF06414.12 ETS60466.1 - 2.1e-08 33.7 1.7 0.3 10.3 0.0 6.8 6 0 0 6 6 6 1 Zeta toxin RNA_helicase PF00910.22 ETS60466.1 - 5.7e-08 33.1 0.3 2.7 8.4 0.0 6.3 6 0 0 6 6 6 1 RNA helicase AAA_19 PF13245.6 ETS60466.1 - 6.3e-08 33.1 5.1 0.78 10.1 0.1 6.4 7 0 0 7 7 4 1 AAA domain Rad17 PF03215.15 ETS60466.1 - 3.7e-07 30.2 0.6 2.5 8.0 0.0 4.9 5 0 0 5 5 4 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 ETS60466.1 - 3.7e-06 27.0 1.9 6.9 6.5 0.0 5.3 5 0 0 5 5 5 0 RsgA GTPase CPT PF07931.12 ETS60466.1 - 5.4e-06 26.4 0.5 0.94 9.3 0.0 5.8 7 0 0 7 7 6 2 Chloramphenicol phosphotransferase-like protein cobW PF02492.19 ETS60466.1 - 9.2e-06 25.3 1.0 7.4 6.1 0.0 5.5 5 0 0 5 5 5 0 CobW/HypB/UreG, nucleotide-binding domain Sigma54_activ_2 PF14532.6 ETS60466.1 - 9.5e-06 25.8 0.5 0.22 11.6 0.0 6.0 6 0 0 6 6 6 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 ETS60466.1 - 1.4e-05 24.9 0.2 0.52 10.0 0.0 5.4 5 0 0 5 5 5 1 IstB-like ATP binding protein DUF815 PF05673.13 ETS60466.1 - 5e-05 22.6 1.5 0.12 11.5 0.0 4.6 6 0 0 6 6 5 1 Protein of unknown function (DUF815) AAA_8 PF12780.7 ETS60466.1 - 0.00016 21.1 0.5 0.59 9.4 0.0 3.7 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 SRP54 PF00448.22 ETS60466.1 - 0.00027 20.6 2.3 1.7 8.3 0.1 4.8 4 0 0 4 4 4 1 SRP54-type protein, GTPase domain AAA_24 PF13479.6 ETS60466.1 - 0.00028 20.7 1.7 21 4.7 0.0 5.7 7 0 0 7 7 5 0 AAA domain PduV-EutP PF10662.9 ETS60466.1 - 0.00039 20.2 0.2 7 6.4 0.1 5.2 5 0 0 5 5 5 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ETS60466.1 - 0.0004 20.3 0.5 4.7 7.1 0.0 4.8 5 0 0 5 5 4 0 NTPase RuvB_N PF05496.12 ETS60466.1 - 0.00044 20.0 3.4 17 5.1 0.0 6.2 7 0 0 7 7 5 0 Holliday junction DNA helicase RuvB P-loop domain TniB PF05621.11 ETS60466.1 - 0.00091 18.7 0.0 12 5.2 0.0 5.6 7 0 0 7 7 6 0 Bacterial TniB protein MMR_HSR1 PF01926.23 ETS60466.1 - 0.0011 19.1 3.7 3.3 7.8 0.0 5.2 6 0 0 6 6 5 0 50S ribosome-binding GTPase Roc PF08477.13 ETS60466.1 - 0.0013 19.0 1.1 24 5.2 0.0 5.5 6 0 0 6 6 5 0 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 ETS60466.1 - 0.0025 17.8 0.2 20 5.1 0.1 4.3 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit AAA_21 PF13304.6 ETS60466.1 - 0.0027 17.6 1.6 0.88 9.3 0.0 5.0 6 0 0 6 6 4 1 AAA domain, putative AbiEii toxin, Type IV TA system Cytidylate_kin PF02224.18 ETS60466.1 - 0.0091 15.7 1.1 18 5.0 0.0 4.3 4 0 0 4 4 4 0 Cytidylate kinase ATP_bind_1 PF03029.17 ETS60466.1 - 0.0093 15.8 1.3 33 4.1 0.0 4.3 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein dNK PF01712.19 ETS60466.1 - 0.014 15.3 0.4 11 5.7 0.0 4.5 5 0 0 5 5 5 0 Deoxynucleoside kinase IPT PF01745.16 ETS60466.1 - 0.024 14.0 0.1 19 4.5 0.0 3.6 3 0 0 3 3 3 0 Isopentenyl transferase KTI12 PF08433.10 ETS60466.1 - 0.032 13.7 0.8 0.56 9.6 0.0 3.5 5 0 0 5 5 3 0 Chromatin associated protein KTI12 ATPase_2 PF01637.18 ETS60466.1 - 0.056 13.3 0.0 20 5.0 0.0 4.0 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea PhoH PF02562.16 ETS60466.1 - 0.062 12.8 0.8 17 4.7 0.0 3.9 4 0 0 4 4 4 0 PhoH-like protein CbiA PF01656.23 ETS60466.1 - 0.068 13.2 2.1 14 5.7 0.2 4.1 5 0 0 5 5 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain G-alpha PF00503.20 ETS60466.1 - 0.099 11.8 1.2 26 3.8 0.0 4.0 4 0 0 4 4 4 0 G-protein alpha subunit TIP49 PF06068.13 ETS60466.1 - 0.15 11.3 2.3 3.9 6.6 0.1 3.5 4 0 0 4 4 4 0 TIP49 P-loop domain AAA_15 PF13175.6 ETS60466.1 - 0.21 11.2 0.0 80 2.8 0.0 3.6 3 0 0 3 3 3 0 AAA ATPase domain MeaB PF03308.16 ETS60466.1 - 0.23 10.4 4.1 9.5 5.1 0.1 4.0 4 0 0 4 4 4 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arginosuc_synth PF00764.19 ETS60468.1 - 1.7e-160 534.6 0.0 2.4e-160 534.1 0.0 1.2 1 0 0 1 1 1 1 Arginosuccinate synthase PGK PF00162.19 ETS60468.1 - 1.6e-146 488.1 1.4 2.2e-146 487.7 1.4 1.2 1 0 0 1 1 1 1 Phosphoglycerate kinase QueC PF06508.13 ETS60468.1 - 0.00035 20.1 0.0 0.00083 18.9 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ETS60468.1 - 0.044 12.6 0.0 0.087 11.6 0.0 1.5 1 1 0 1 1 1 0 tRNA methyl transferase RNA_pol_Rpc4 PF05132.14 ETS60469.1 - 2e-32 112.7 0.3 2e-32 112.7 0.3 4.7 5 1 0 5 5 5 1 RNA polymerase III RPC4 W2 PF02020.18 ETS60470.1 - 1.2e-14 54.1 1.1 1.2e-14 54.1 1.1 2.2 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 ETS60470.1 - 1.8e-11 43.3 3.7 8.6e-05 22.1 0.7 3.8 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 ETS60470.1 - 4.3e-09 36.3 0.0 7.7e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ETS60470.1 - 0.00067 20.1 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 ETS60470.1 - 3.2 7.6 10.3 10 6.0 6.3 3.6 3 1 1 4 4 4 0 Hexapeptide repeat of succinyl-transferase CLP1_P PF16575.5 ETS60471.1 - 3.5e-25 88.9 0.0 5.2e-12 45.9 0.0 2.6 2 0 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 ETS60471.1 - 0.062 13.7 1.6 0.19 12.1 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain CLN3 PF02487.17 ETS60472.1 - 3e-118 395.3 0.2 1.6e-117 393.0 0.2 1.9 1 1 0 1 1 1 1 CLN3 protein Gate PF07670.14 ETS60472.1 - 0.013 15.8 0.1 0.085 13.1 0.0 2.3 2 0 0 2 2 2 0 Nucleoside recognition Snf7 PF03357.21 ETS60473.1 - 2.5e-41 141.2 19.2 2.4e-40 137.9 19.1 2.0 2 0 0 2 2 2 1 Snf7 Exonuc_VII_L PF02601.15 ETS60473.1 - 0.059 12.9 7.2 0.075 12.6 7.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ist1 PF03398.14 ETS60473.1 - 0.18 11.7 6.7 0.25 11.3 6.7 1.4 1 1 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DDE_Tnp_ISL3 PF01610.17 ETS60473.1 - 0.2 11.3 5.4 0.29 10.8 5.4 1.2 1 0 0 1 1 1 0 Transposase TPR_MLP1_2 PF07926.12 ETS60473.1 - 0.53 10.3 13.5 2.1 8.4 6.9 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein KxDL PF10241.9 ETS60473.1 - 0.63 10.4 9.2 3.1 8.2 1.9 2.8 2 1 0 2 2 2 0 Uncharacterized conserved protein GIT_CC PF16559.5 ETS60473.1 - 1 9.3 6.6 3.3 7.7 0.1 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PspA_IM30 PF04012.12 ETS60473.1 - 1.3 8.6 21.4 0.024 14.2 6.5 2.1 1 1 0 2 2 2 0 PspA/IM30 family DUF4407 PF14362.6 ETS60473.1 - 4.9 6.4 15.3 1.8 7.9 12.7 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) COG2 PF06148.11 ETS60473.1 - 5.2 7.2 10.4 0.74 9.9 4.6 2.3 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Uds1 PF15456.6 ETS60473.1 - 9.2 6.4 14.5 0.35 11.1 0.8 2.8 2 1 1 3 3 3 0 Up-regulated During Septation Pkinase PF00069.25 ETS60474.1 - 1.9e-64 217.6 0.0 2.4e-64 217.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60474.1 - 1.5e-34 119.4 0.0 2.3e-34 118.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS60474.1 - 1.7e-07 30.9 0.0 3e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETS60474.1 - 4.3e-05 22.5 0.6 8.2e-05 21.5 0.0 1.9 2 1 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETS60474.1 - 0.016 14.5 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETS60474.1 - 0.075 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ETS60474.1 - 0.099 12.3 0.0 2.7 7.5 0.0 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 ETS60474.1 - 0.15 11.6 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 ETS60474.1 - 0.21 10.6 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 HLH PF00010.26 ETS60475.1 - 0.00028 20.8 0.1 0.00063 19.6 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Vasculin PF15337.6 ETS60475.1 - 0.16 12.8 4.5 0.49 11.3 4.5 1.8 1 0 0 1 1 1 0 Vascular protein family Vasculin-like 1 D123 PF07065.14 ETS60476.1 - 3.8e-92 308.7 0.0 4.5e-92 308.5 0.0 1.0 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 ETS60476.1 - 0.01 15.8 0.1 0.019 15.0 0.1 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 ETS60476.1 - 0.039 13.8 0.1 0.073 12.9 0.1 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 RRM_1 PF00076.22 ETS60477.1 - 1.3e-10 40.9 0.1 4e-10 39.4 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3602 PF12223.8 ETS60477.1 - 4.1 8.1 9.1 0.97 10.1 5.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3602) Methyltrn_RNA_3 PF02598.17 ETS60478.1 - 2e-104 349.1 0.0 2.6e-104 348.7 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase Ion_trans PF00520.31 ETS60480.1 - 1.4e-05 24.4 15.7 1.4e-05 24.4 15.7 1.9 2 0 0 2 2 2 1 Ion transport protein Kei1 PF08552.11 ETS60481.1 - 1.9e-54 184.5 2.9 1.9e-54 184.5 2.9 1.7 2 0 0 2 2 2 1 Inositolphosphorylceramide synthase subunit Kei1 Ribosomal_L26 PF16906.5 ETS60482.1 - 2e-31 108.3 7.5 9.1e-17 61.3 0.7 2.4 2 0 0 2 2 2 2 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 ETS60482.1 - 9.6e-07 28.6 0.6 2.3e-06 27.4 0.6 1.6 1 0 0 1 1 1 1 KOW motif WD40 PF00400.32 ETS60483.1 - 4.5e-44 147.6 18.4 9.3e-06 26.3 0.0 9.4 8 1 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 ETS60483.1 - 5.8e-10 38.9 0.0 1.4e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETS60483.1 - 9.2e-10 38.2 0.1 2.3e-09 36.9 0.1 1.7 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ETS60483.1 - 1.7e-06 27.0 11.4 0.057 12.1 0.0 6.5 5 1 2 7 7 7 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETS60483.1 - 0.0047 16.3 0.0 1.5 8.0 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain F-box_4 PF15966.5 ETS60483.1 - 0.0084 16.0 0.0 0.023 14.5 0.0 1.8 1 0 0 1 1 1 1 F-box PALB2_WD40 PF16756.5 ETS60483.1 - 0.25 10.2 5.1 26 3.6 0.0 4.9 4 2 2 6 6 6 0 Partner and localizer of BRCA2 WD40 domain Chromo PF00385.24 ETS60484.1 - 3.2e-14 52.6 0.4 8.5e-14 51.2 0.4 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 ETS60484.1 - 8.9e-14 51.3 0.1 9.8e-09 35.2 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain LIDHydrolase PF10230.9 ETS60485.1 - 2.3e-42 145.4 0.0 6.5e-42 143.9 0.0 1.6 2 0 0 2 2 2 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 ETS60485.1 - 2.6e-08 33.4 0.0 4.2e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS60485.1 - 6e-05 23.8 7.9 9.4e-05 23.1 7.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 ETS60485.1 - 0.0014 18.4 0.5 0.0049 16.6 0.5 1.8 1 1 0 1 1 1 1 PGAP1-like protein Peptidase_S9 PF00326.21 ETS60485.1 - 0.014 14.9 0.1 0.03 13.8 0.1 1.6 1 1 0 1 1 1 0 Prolyl oligopeptidase family Lipase_3 PF01764.25 ETS60485.1 - 0.017 15.0 0.1 0.033 14.1 0.1 1.5 1 0 0 1 1 1 0 Lipase (class 3) Ser_hydrolase PF06821.13 ETS60485.1 - 0.028 14.3 0.1 0.067 13.1 0.1 1.8 1 0 0 1 1 1 0 Serine hydrolase Abhydrolase_1 PF00561.20 ETS60485.1 - 0.11 12.1 0.2 0.62 9.7 0.2 2.0 1 1 0 1 1 1 0 alpha/beta hydrolase fold Myosin_N PF02736.19 ETS60485.1 - 0.15 11.9 0.2 1 9.2 0.1 2.2 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain Pkinase PF00069.25 ETS60486.1 - 3.1e-53 180.8 0.0 4e-53 180.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60486.1 - 5e-41 140.7 0.0 7.5e-41 140.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS60486.1 - 1.2e-06 27.6 0.0 1.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETS60486.1 - 0.0046 16.9 1.8 0.066 13.1 1.8 2.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETS60486.1 - 0.0083 15.5 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Ank_4 PF13637.6 ETS60487.1 - 1.7e-17 63.5 0.4 3.4e-07 30.7 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS60487.1 - 4.2e-15 56.1 0.1 6.4e-06 26.7 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETS60487.1 - 2.6e-13 49.7 0.4 1.7e-05 25.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETS60487.1 - 1e-12 48.0 1.3 1.2e-05 25.5 0.0 3.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETS60487.1 - 5.9e-12 44.7 0.6 0.0027 18.1 0.1 4.0 3 0 0 3 3 3 2 Ankyrin repeat AhpC-TSA PF00578.21 ETS60488.1 - 1.2e-23 83.4 0.0 1.6e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ETS60488.1 - 7e-13 48.5 0.1 9.5e-13 48.1 0.1 1.1 1 0 0 1 1 1 1 Redoxin HMG14_17 PF01101.18 ETS60488.1 - 0.038 14.9 6.2 0.072 14.1 6.2 1.5 1 0 0 1 1 1 0 HMG14 and HMG17 AhpC-TSA_2 PF13911.6 ETS60488.1 - 0.059 13.5 0.0 0.08 13.1 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme PTPA PF03095.15 ETS60490.1 - 7e-102 340.9 0.0 8.3e-102 340.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DUF4633 PF15464.6 ETS60491.1 - 0.54 10.4 3.1 0.42 10.8 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) tRNA-synt_2b PF00587.25 ETS60492.1 - 1.9e-35 122.4 0.0 3.4e-35 121.6 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ETS60492.1 - 3.7e-20 71.9 0.1 7.5e-20 70.9 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 ETS60492.1 - 8.7e-14 51.3 0.0 1.4e-11 44.3 0.0 2.5 2 0 0 2 2 2 2 TGS domain tRNA_SAD PF07973.14 ETS60492.1 - 5.7e-10 39.1 0.0 1.1e-09 38.2 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain WW PF00397.26 ETS60493.1 - 6.9e-05 22.8 0.6 6.9e-05 22.8 0.6 1.9 2 0 0 2 2 2 1 WW domain CDC45 PF02724.14 ETS60493.1 - 0.14 10.5 7.3 0.17 10.1 7.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETS60493.1 - 1.8 7.3 2.6 2.3 6.9 2.6 1.1 1 0 0 1 1 1 0 Presenilin GCIP PF13324.6 ETS60494.1 - 2.1e-09 37.4 15.4 7.4e-09 35.6 2.1 4.2 3 2 1 4 4 4 2 Grap2 and cyclin-D-interacting Aminotran_5 PF00266.19 ETS60494.1 - 4.8e-09 35.6 0.0 1e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class-V GGACT PF06094.12 ETS60495.1 - 3.5e-14 53.4 0.0 7.4e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Acyltransferase PF01553.21 ETS60495.1 - 3.8e-12 46.0 0.0 7.3e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Formyl_trans_N PF00551.19 ETS60496.1 - 2.8e-17 63.0 0.0 4.2e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 ETS60496.1 - 0.003 17.8 0.1 0.006 16.8 0.1 1.6 1 1 0 1 1 1 1 Formyl transferase, C-terminal domain DHHC PF01529.20 ETS60497.1 - 1.8e-30 105.8 0.6 3.2e-30 105.0 0.6 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase zf-tcix PF14952.6 ETS60497.1 - 0.15 11.7 1.6 0.31 10.7 1.6 1.4 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding DUF35_N PF12172.8 ETS60497.1 - 3.3 7.7 7.0 8.9 6.3 7.0 1.7 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Aminotran_1_2 PF00155.21 ETS60498.1 - 3.3e-56 191.0 0.0 4.4e-56 190.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETS60498.1 - 0.0025 17.1 0.0 0.0038 16.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_MocR PF12897.7 ETS60498.1 - 0.015 14.1 0.0 0.078 11.8 0.0 1.9 1 1 0 1 1 1 0 Alanine-glyoxylate amino-transferase Aminotran_3 PF00202.21 ETS60498.1 - 0.053 12.2 0.0 0.11 11.1 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-III Cys_Met_Meta_PP PF01053.20 ETS60498.1 - 0.067 11.7 0.0 0.12 10.8 0.0 1.4 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Tannase PF07519.11 ETS60498.1 - 0.16 10.9 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase MFS_1 PF07690.16 ETS60499.1 - 3.7e-09 36.0 26.3 6.6e-09 35.2 26.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ETS60499.1 - 2.2e-05 24.2 4.9 2.2e-05 24.2 4.9 2.7 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 Cation_ATPase_C PF00689.21 ETS60499.1 - 0.16 11.6 12.9 0.84 9.3 1.1 3.8 2 1 1 3 3 3 0 Cation transporting ATPase, C-terminus Ribosomal_L6 PF00347.23 ETS60501.1 - 9.1e-22 77.5 0.3 4.4e-08 33.7 0.1 3.2 2 1 1 3 3 3 3 Ribosomal protein L6 NUDIX PF00293.28 ETS60502.1 - 1.9e-25 89.4 0.0 2.7e-25 88.9 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain CSN8_PSD8_EIF3K PF10075.9 ETS60503.1 - 2.8e-31 108.4 0.1 3.3e-30 105.0 0.1 2.2 1 1 0 1 1 1 1 CSN8/PSMD8/EIF3K family Exonuc_X-T_C PF08411.10 ETS60503.1 - 0.05 12.7 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Exonuclease C-terminal RRM_1 PF00076.22 ETS60504.1 - 1.2e-12 47.4 0.5 2.1e-08 33.9 0.0 3.3 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Yae1_N PF09811.9 ETS60504.1 - 6e-08 32.3 7.6 1.4e-07 31.1 7.6 1.7 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Acyl-CoA_dh_1 PF00441.24 ETS60505.1 - 7.2e-44 149.6 2.3 1.3e-43 148.8 2.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETS60505.1 - 1.5e-36 125.5 0.0 3e-36 124.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETS60505.1 - 1.4e-26 92.5 0.1 3.3e-26 91.3 0.1 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETS60505.1 - 8.1e-20 71.5 0.2 8.1e-20 71.5 0.2 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 ETS60505.1 - 0.15 12.6 0.0 0.3 11.6 0.0 1.6 1 0 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal UBM PF14377.6 ETS60506.1 - 0.23 11.0 0.0 0.23 11.0 0.0 3.3 3 0 0 3 3 3 0 Ubiquitin binding region Mgm101p PF06420.12 ETS60507.1 - 6.4e-81 269.9 0.0 8.4e-81 269.5 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Leo1 PF04004.13 ETS60508.1 - 6.8e-51 172.4 0.1 1.7e-50 171.1 0.1 1.7 1 0 0 1 1 1 1 Leo1-like protein Ribosomal_L37e PF01907.19 ETS60509.1 - 1.5e-26 92.3 12.1 1.5e-26 92.3 12.1 1.6 2 1 0 2 2 2 1 Ribosomal protein L37e SelR PF01641.18 ETS60509.1 - 0.018 15.1 0.3 0.02 15.0 0.3 1.2 1 0 0 1 1 1 0 SelR domain DZR PF12773.7 ETS60509.1 - 0.031 14.3 1.5 0.047 13.7 1.5 1.3 1 0 0 1 1 1 0 Double zinc ribbon DUF2845 PF11006.8 ETS60509.1 - 0.039 14.1 0.3 0.047 13.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) HypA PF01155.19 ETS60509.1 - 0.079 13.0 0.8 0.1 12.6 0.8 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 ETS60509.1 - 0.15 11.5 2.0 0.29 10.6 2.0 1.4 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_L7Ae PF01248.26 ETS60510.1 - 2.1e-22 78.7 0.0 2.4e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FKBP_C PF00254.28 ETS60510.1 - 0.033 14.5 0.1 0.093 13.1 0.0 1.6 2 0 0 2 2 2 0 FKBP-type peptidyl-prolyl cis-trans isomerase GTP_cyclohydro2 PF00925.20 ETS60513.1 - 1.8e-63 213.0 0.0 4.2e-63 211.8 0.0 1.6 1 1 0 1 1 1 1 GTP cyclohydrolase II Arm PF00514.23 ETS60514.1 - 2e-98 319.8 6.3 4.4e-13 48.8 0.0 8.3 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 ETS60514.1 - 1.5e-24 86.3 6.3 3e-24 85.3 6.3 1.6 1 0 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.6 ETS60514.1 - 2.7e-22 78.8 0.4 1.1e-08 35.3 0.0 6.4 4 3 3 7 7 7 5 HEAT-like repeat HEAT_2 PF13646.6 ETS60514.1 - 3.9e-21 75.2 0.1 3.5e-06 27.3 0.0 6.0 1 1 4 6 6 6 6 HEAT repeats Arm_3 PF16186.5 ETS60514.1 - 6.4e-21 73.7 0.3 1.3e-20 72.7 0.3 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT PF02985.22 ETS60514.1 - 1.2e-17 62.5 0.5 7.8e-05 22.6 0.0 7.1 8 0 0 8 8 7 3 HEAT repeat Adaptin_N PF01602.20 ETS60514.1 - 1e-06 27.7 0.0 0.00011 21.0 0.0 2.7 1 1 2 3 3 3 1 Adaptin N terminal region RICTOR_V PF14668.6 ETS60514.1 - 5e-05 23.5 0.7 0.043 14.1 0.0 3.8 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_N PF03224.14 ETS60514.1 - 0.00048 19.5 0.0 1.1 8.5 0.0 3.3 1 1 1 2 2 2 2 V-ATPase subunit H Arm_2 PF04826.13 ETS60514.1 - 0.00085 18.9 0.0 0.96 8.8 0.0 3.4 2 1 2 4 4 4 2 Armadillo-like V-ATPase_H_C PF11698.8 ETS60514.1 - 0.001 19.1 0.0 0.66 10.1 0.0 3.7 4 1 0 4 4 4 1 V-ATPase subunit H HEAT_PBS PF03130.16 ETS60514.1 - 0.0036 17.8 1.0 1.7 9.6 0.1 4.3 5 0 0 5 5 4 1 PBS lyase HEAT-like repeat Mo25 PF08569.11 ETS60514.1 - 0.0077 15.6 0.0 0.023 14.1 0.0 1.7 2 0 0 2 2 2 1 Mo25-like ABC_trans_aux PF03886.13 ETS60514.1 - 0.02 14.4 0.1 0.1 12.2 0.1 2.2 2 0 0 2 2 2 0 ABC-type transport auxiliary lipoprotein component DCB PF16213.5 ETS60514.1 - 0.073 12.7 0.0 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 Dimerisation and cyclophilin-binding domain of Mon2 Nefa_Nip30_N PF10187.9 ETS60515.1 - 4.9e-21 75.1 6.6 4.9e-21 75.1 6.6 1.6 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 bZIP_2 PF07716.15 ETS60516.1 - 0.0038 17.3 6.9 0.0073 16.4 6.9 1.4 1 0 0 1 1 1 1 Basic region leucine zipper WAC_Acf1_DNA_bd PF10537.9 ETS60517.1 - 6.6e-36 122.9 0.1 6.6e-36 122.9 0.1 2.2 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 ETS60517.1 - 1.7e-25 89.4 0.0 1.7e-25 89.4 0.0 2.8 3 0 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 ETS60517.1 - 3.8e-10 39.9 0.5 9.1e-10 38.7 0.5 1.7 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 ETS60517.1 - 0.0024 17.3 0.0 0.0058 16.2 0.0 1.5 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PP2C PF00481.21 ETS60518.1 - 3.7e-37 128.3 0.0 1.3e-33 116.7 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C Ubiq_cyt_C_chap PF03981.12 ETS60519.1 - 2.5e-27 95.7 0.0 2.8e-25 89.0 0.0 2.2 2 0 0 2 2 2 2 Ubiquinol-cytochrome C chaperone CDC45 PF02724.14 ETS60520.1 - 8 4.6 7.6 13 4.0 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Med15_fungi PF05397.12 ETS60522.1 - 1.3e-28 99.5 2.6 1.3e-28 99.5 2.6 6.0 6 1 0 6 6 6 1 Mediator complex subunit 15 ARID PF01388.21 ETS60522.1 - 2e-19 70.0 0.0 1e-18 67.8 0.0 2.4 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain ABC2_membrane PF01061.24 ETS60523.1 - 9.5e-37 126.5 18.1 9.5e-37 126.5 18.1 1.9 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ETS60523.1 - 2.8e-23 82.9 0.0 5.1e-23 82.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ETS60523.1 - 0.0012 19.3 0.2 0.0023 18.3 0.2 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETS60523.1 - 0.023 14.6 0.1 0.039 13.8 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 ETS60523.1 - 0.035 13.9 0.0 1.7 8.4 0.0 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ETS60523.1 - 0.058 13.9 0.0 0.095 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETS60523.1 - 0.18 12.0 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC2_membrane_3 PF12698.7 ETS60523.1 - 0.21 10.6 25.6 0.48 9.5 25.6 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein Dynamin_N PF00350.23 ETS60523.1 - 0.22 11.6 0.0 0.43 10.6 0.0 1.5 1 0 0 1 1 1 0 Dynamin family Ebp2 PF05890.12 ETS60525.1 - 2e-87 293.1 16.4 2e-87 293.1 16.4 2.4 3 0 0 3 3 3 1 Eukaryotic rRNA processing protein EBP2 Pkinase_Tyr PF07714.17 ETS60526.1 - 1e-46 159.3 0.0 1.5e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETS60526.1 - 3.6e-46 157.7 0.0 5.5e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain C1_1 PF00130.22 ETS60526.1 - 3.7e-06 26.7 4.5 7.1e-06 25.8 4.5 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kdo PF06293.14 ETS60526.1 - 0.004 16.5 0.0 0.0064 15.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETS60526.1 - 0.0055 15.7 0.0 0.0084 15.1 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETS60526.1 - 0.0093 15.9 0.1 0.045 13.7 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family C1_2 PF03107.16 ETS60526.1 - 0.066 13.5 3.1 0.13 12.6 3.1 1.4 1 0 0 1 1 1 0 C1 domain Pkinase_fungal PF17667.1 ETS60526.1 - 0.11 11.3 0.0 0.18 10.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PHD PF00628.29 ETS60526.1 - 0.18 11.7 3.8 0.36 10.8 3.8 1.5 1 0 0 1 1 1 0 PHD-finger Kelch_4 PF13418.6 ETS60527.1 - 7.1e-18 64.4 8.2 3e-05 23.9 0.1 5.7 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ETS60527.1 - 9.3e-09 35.1 4.9 0.012 15.6 0.0 5.1 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ETS60527.1 - 1.3e-08 34.9 13.5 0.061 13.6 0.4 6.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ETS60527.1 - 0.00014 22.0 10.2 0.42 11.0 0.0 5.4 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ETS60527.1 - 0.00055 19.8 1.9 1.8 8.6 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETS60527.1 - 0.043 13.4 0.1 3.9 7.1 0.0 3.3 3 0 0 3 3 3 0 Kelch motif HET PF06985.11 ETS60527.1 - 0.1 13.0 0.0 0.35 11.2 0.0 1.9 1 0 0 1 1 1 0 Heterokaryon incompatibility protein (HET) Fungal_trans PF04082.18 ETS60528.1 - 8.6e-22 77.4 0.0 1.7e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS60528.1 - 3e-06 27.2 6.0 5.2e-06 26.5 6.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AMP-binding PF00501.28 ETS60529.1 - 2.1e-87 293.5 0.0 2.9e-87 293.0 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS60529.1 - 8.2e-09 36.3 0.2 2.2e-08 35.0 0.2 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain COX5B PF01215.19 ETS60530.1 - 3.2e-42 143.3 0.0 3.7e-42 143.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-C2H2_3 PF13878.6 ETS60530.1 - 0.05 13.4 0.2 0.078 12.8 0.2 1.4 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO CHZ PF09649.10 ETS60531.1 - 0.053 13.0 6.3 0.51 9.9 4.8 2.7 1 1 0 1 1 1 0 Histone chaperone domain CHZ GST_N PF02798.20 ETS60532.1 - 2e-16 60.1 0.0 3.6e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ETS60532.1 - 1e-10 41.8 0.0 1.9e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETS60532.1 - 2.2e-08 34.0 0.2 3.7e-08 33.3 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETS60532.1 - 2.3e-07 30.9 0.0 3.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ETS60532.1 - 3.9e-07 30.3 0.0 7.1e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETS60532.1 - 1.3e-06 28.5 0.0 2.1e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain MAPEG PF01124.18 ETS60533.1 - 1.3e-13 51.0 2.0 2e-13 50.4 2.0 1.4 1 0 0 1 1 1 1 MAPEG family Mago-bind PF09282.10 ETS60534.1 - 2.8e-14 52.7 3.0 2.8e-14 52.7 3.0 2.5 2 0 0 2 2 2 1 Mago binding F-box-like PF12937.7 ETS60535.1 - 0.0012 18.7 1.2 0.0026 17.6 1.2 1.6 1 0 0 1 1 1 1 F-box-like Ribul_P_3_epim PF00834.19 ETS60536.1 - 2e-62 210.1 0.1 2.8e-62 209.6 0.1 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family QRPTase_C PF01729.19 ETS60536.1 - 0.081 12.7 0.0 0.21 11.4 0.0 1.7 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain C2 PF00168.30 ETS60537.1 - 3.8e-24 84.9 0.0 2.7e-14 53.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain Nup84_Nup100 PF04121.13 ETS60538.1 - 9.6e-169 562.9 0.0 1.1e-168 562.7 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 TFIIB PF00382.19 ETS60539.1 - 3.4e-37 126.3 0.5 1e-21 76.8 0.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ETS60539.1 - 5.2e-13 48.3 1.4 8.3e-13 47.6 1.4 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 ETS60539.1 - 0.0023 18.0 0.0 0.049 13.7 0.0 2.2 2 0 0 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.20 ETS60539.1 - 0.0064 16.5 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain PG_binding_1 PF01471.18 ETS60539.1 - 0.078 13.2 0.3 0.21 11.8 0.1 1.7 2 0 0 2 2 2 0 Putative peptidoglycan binding domain Cyclin_N PF00134.23 ETS60539.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Cyclin, N-terminal domain YjbE PF11106.8 ETS60539.1 - 0.26 11.5 4.9 0.08 13.2 1.6 1.8 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE Svf1_C PF17187.4 ETS60540.1 - 1.2e-51 174.8 0.0 1.8e-51 174.2 0.0 1.3 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 ETS60540.1 - 3.9e-41 140.8 0.0 5.5e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Aconitase PF00330.20 ETS60541.1 - 4.8e-112 375.3 0.0 5.1e-111 371.9 0.0 2.1 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ETS60541.1 - 3.6e-20 72.6 0.0 1.4e-19 70.7 0.0 1.9 1 1 0 1 1 1 1 Aconitase C-terminal domain Cyclin_N PF00134.23 ETS60542.1 - 1.7e-37 128.0 0.3 2.9e-37 127.2 0.3 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETS60542.1 - 3.3e-05 24.0 0.2 3.3e-05 24.0 0.2 2.1 2 0 0 2 2 2 1 Cyclin, C-terminal domain DUF3246 PF11596.8 ETS60542.1 - 4.7 6.6 14.5 0.46 9.9 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) TFIIE-A_C PF11521.8 ETS60542.1 - 6.6 7.1 10.7 3.5 8.0 5.2 2.6 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha GatB_N PF02934.15 ETS60546.1 - 1.6e-101 339.3 0.0 3.3e-101 338.3 0.0 1.5 1 1 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 ETS60546.1 - 5.8e-26 91.2 0.0 1.2e-25 90.1 0.0 1.5 1 1 0 1 1 1 1 GatB domain Beta_elim_lyase PF01212.21 ETS60547.1 - 2.2e-69 234.0 0.0 2.9e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Pcc1 PF09341.10 ETS60547.1 - 6.4e-17 61.5 0.4 2.4e-16 59.6 0.2 2.1 2 0 0 2 2 2 1 Transcription factor Pcc1 Aminotran_1_2 PF00155.21 ETS60547.1 - 0.00096 18.4 0.0 0.0017 17.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 ETS60547.1 - 0.0029 17.0 0.0 0.0042 16.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family RPN2_C PF18004.1 ETS60548.1 - 7.7e-42 142.9 0.8 9e-41 139.5 0.6 2.4 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 ETS60548.1 - 1.5e-40 135.6 18.4 1.9e-08 34.4 0.0 8.7 8 0 0 8 8 8 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ETS60548.1 - 1.8e-16 60.3 14.1 1.5e-13 50.9 0.0 5.4 5 1 1 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 ETS60548.1 - 4.4e-05 23.9 5.8 0.06 13.9 0.0 5.4 4 2 2 6 6 6 2 HEAT-like repeat HEAT PF02985.22 ETS60548.1 - 7.8e-05 22.6 0.2 2.8 8.4 0.0 4.4 4 0 0 4 4 4 2 HEAT repeat HEAT_PBS PF03130.16 ETS60548.1 - 0.047 14.4 1.5 1.3e+02 3.8 0.0 4.9 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat Katanin_con80 PF13925.6 ETS60548.1 - 0.092 12.8 0.0 29 4.6 0.0 3.1 3 0 0 3 3 3 0 con80 domain of Katanin Hus1 PF04005.12 ETS60549.1 - 3.2e-86 289.1 0.4 3.6e-86 288.9 0.4 1.0 1 0 0 1 1 1 1 Hus1-like protein PCNA_N PF00705.18 ETS60549.1 - 0.0012 18.5 0.4 0.0027 17.4 0.2 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain Rad9 PF04139.13 ETS60549.1 - 0.0019 17.7 0.2 0.012 15.1 0.2 2.1 1 1 0 1 1 1 1 Rad9 VPS28 PF03997.12 ETS60550.1 - 1.3e-70 237.0 3.4 1.4e-70 236.8 3.4 1.0 1 0 0 1 1 1 1 VPS28 protein DUF4745 PF15923.5 ETS60550.1 - 0.0016 18.4 0.3 0.32 11.0 0.1 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4745) Rgp1 PF08737.10 ETS60550.1 - 0.1 11.8 1.1 0.13 11.4 1.1 1.1 1 0 0 1 1 1 0 Rgp1 tRNA-synt_1c PF00749.21 ETS60551.1 - 1.7e-110 368.8 0.0 2.8e-110 368.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ETS60551.1 - 2.7e-34 118.5 0.2 5.3e-34 117.6 0.2 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GST_C PF00043.25 ETS60551.1 - 8.3e-05 22.7 2.0 0.00047 20.3 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain bMG3 PF11974.8 ETS60551.1 - 0.00041 20.3 0.2 0.11 12.5 0.0 2.9 2 0 0 2 2 2 1 Bacterial alpha-2-macroglobulin MG3 domain GST_C_2 PF13410.6 ETS60551.1 - 0.014 15.4 0.1 0.043 13.8 0.1 1.9 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS60551.1 - 0.036 14.3 3.2 0.091 13.0 0.0 3.2 4 0 0 4 4 4 0 Glutathione S-transferase, C-terminal domain IMUP PF15761.5 ETS60551.1 - 0.055 14.2 10.8 0.15 12.8 10.8 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein LSM PF01423.22 ETS60552.1 - 4.9e-17 61.4 0.2 6.8e-17 60.9 0.2 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ETS60552.1 - 0.037 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Hfq protein Propep_M14 PF02244.16 ETS60552.1 - 0.095 13.1 0.9 0.13 12.7 0.9 1.2 1 0 0 1 1 1 0 Carboxypeptidase activation peptide Rad60-SLD PF11976.8 ETS60554.1 - 2.5e-07 30.4 0.0 6.1e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBX PF00789.20 ETS60554.1 - 0.062 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 UBX domain HATPase_c PF02518.26 ETS60557.1 - 4.8e-20 72.1 0.2 1.1e-19 70.9 0.2 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ETS60557.1 - 4.5e-18 65.4 0.0 3.4e-10 40.1 0.0 3.4 3 0 0 3 3 3 3 Response regulator receiver domain HisKA PF00512.25 ETS60557.1 - 2.9e-16 59.3 0.0 7.7e-16 57.9 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain U1snRNP70_N PF12220.8 ETS60558.1 - 5.1e-22 78.3 0.5 1.7e-21 76.6 0.5 2.0 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 ETS60558.1 - 9.4e-18 63.8 0.0 1.5e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 ETS60558.1 - 0.036 14.3 0.0 0.061 13.5 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain RRM_7 PF16367.5 ETS60558.1 - 0.049 13.8 0.0 0.14 12.3 0.0 1.7 1 1 0 1 1 1 0 RNA recognition motif RNA_pol_Rpb1_7 PF04990.12 ETS60558.1 - 0.12 12.4 0.1 2.1 8.3 0.0 2.1 1 1 0 2 2 2 0 RNA polymerase Rpb1, domain 7 Proteasome PF00227.26 ETS60559.1 - 4.3e-50 169.8 0.1 5.6e-50 169.5 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ETS60559.1 - 1.4e-12 47.0 0.3 2.2e-12 46.4 0.3 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature CCDC168_N PF15804.5 ETS60560.1 - 0.08 12.8 0.2 4.3 7.1 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 168 PE PF00934.20 ETS60561.1 - 0.032 14.5 1.2 0.077 13.3 1.2 1.6 1 0 0 1 1 1 0 PE family Na_H_Exchanger PF00999.21 ETS60562.1 - 1.5e-55 188.6 46.9 2.1e-55 188.1 46.9 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Polysacc_deac_2 PF04748.13 ETS60562.1 - 0.059 12.5 0.0 0.24 10.5 0.0 1.8 2 0 0 2 2 2 0 Divergent polysaccharide deacetylase TUDOR PF00567.24 ETS60563.1 - 8.8e-07 29.0 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 ETS60563.1 - 2.9e-06 26.8 0.0 2.9e-06 26.8 0.0 3.5 1 1 2 3 3 3 1 Survival motor neuron protein (SMN) Tudor_3 PF18115.1 ETS60563.1 - 0.00084 19.1 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain UL42 PF17638.2 ETS60563.1 - 0.021 14.8 3.9 0.021 14.8 3.9 3.1 2 1 0 2 2 2 0 HCMV UL42 PWWP PF00855.17 ETS60563.1 - 0.034 14.5 0.5 0.4 11.1 0.0 2.2 2 0 0 2 2 2 0 PWWP domain Agenet PF05641.12 ETS60563.1 - 0.11 13.0 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Agenet domain Hydrolase_4 PF12146.8 ETS60564.1 - 8.1e-12 44.9 1.0 1.7e-11 43.9 1.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS60564.1 - 5.1e-11 42.7 0.1 4.8e-10 39.5 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS60564.1 - 1.1e-06 29.5 0.0 1.3e-06 29.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Adhesin_E PF16747.5 ETS60564.1 - 0.035 14.2 0.0 5.1 7.2 0.0 2.3 2 0 0 2 2 2 0 Surface-adhesin protein E FSH1 PF03959.13 ETS60564.1 - 0.058 13.0 0.3 0.5 10.0 0.3 2.1 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 ETS60564.1 - 0.099 12.1 0.1 0.65 9.4 0.0 2.4 3 1 0 3 3 3 0 Prolyl oligopeptidase family CH PF00307.31 ETS60565.1 - 2.9e-81 268.8 0.0 1e-20 74.0 0.0 4.1 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 ETS60565.1 - 2.2e-07 31.2 0.6 6.8e-07 29.6 0.2 2.0 2 0 0 2 2 2 1 EF-hand domain pair CAMSAP_CH PF11971.8 ETS60565.1 - 6.7e-07 29.1 0.0 0.23 11.3 0.0 4.1 4 0 0 4 4 4 2 CAMSAP CH domain EF-hand_1 PF00036.32 ETS60565.1 - 0.00022 20.6 0.3 0.095 12.3 0.0 3.5 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ETS60565.1 - 0.00093 18.9 0.1 4 7.6 0.0 3.7 3 0 0 3 3 3 1 EF-hand domain CH_2 PF06294.11 ETS60565.1 - 0.012 15.7 0.0 4.1 7.6 0.0 2.8 2 0 0 2 2 2 0 CH-like domain in sperm protein EF-hand_8 PF13833.6 ETS60565.1 - 0.089 12.7 0.0 0.35 10.7 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain pair Prefoldin_2 PF01920.20 ETS60566.1 - 5.7e-20 71.2 3.8 7.4e-20 70.9 3.8 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 ETS60566.1 - 0.00068 19.5 2.1 0.00085 19.2 2.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit TMF_TATA_bd PF12325.8 ETS60566.1 - 0.015 15.5 3.0 0.017 15.4 2.0 1.6 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Cep57_MT_bd PF06657.13 ETS60566.1 - 0.098 13.1 0.7 0.098 13.1 0.7 2.5 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Helo_like_N PF17111.5 ETS60566.1 - 0.19 11.1 2.8 0.47 9.8 0.8 2.0 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins NDUFB10 PF10249.9 ETS60567.1 - 0.015 15.8 0.3 0.017 15.6 0.3 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 BK_channel_a PF03493.18 ETS60567.1 - 0.14 12.4 0.0 0.16 12.2 0.0 1.0 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Methyltransf_4 PF02390.17 ETS60568.1 - 4.3e-49 166.3 0.0 1.1e-36 125.9 0.0 2.1 2 0 0 2 2 2 2 Putative methyltransferase Methyltransf_25 PF13649.6 ETS60568.1 - 0.007 17.0 0.0 0.086 13.6 0.0 2.4 1 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ETS60568.1 - 0.012 15.1 0.0 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 ETS60568.1 - 0.021 14.6 0.0 0.072 12.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 ETS60568.1 - 0.035 14.8 0.0 0.12 13.2 0.0 2.0 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 ETS60568.1 - 0.041 14.5 0.0 6.8 7.4 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Amidase02_C PF12123.8 ETS60568.1 - 0.061 13.0 0.0 0.23 11.2 0.0 2.0 1 0 0 1 1 1 0 N-acetylmuramoyl-l-alanine amidase DUF3292 PF11696.8 ETS60569.1 - 2.7e-11 42.6 0.4 2e-05 23.2 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF3292) NAP PF00956.18 ETS60570.1 - 3.1e-22 79.0 12.4 1.2e-21 77.1 6.2 3.2 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) HSDR_N_2 PF13588.6 ETS60570.1 - 0.0078 16.2 0.2 0.012 15.6 0.2 1.2 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) YL1 PF05764.13 ETS60570.1 - 1.3 9.1 7.0 1.6 8.8 7.0 1.3 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 ETS60570.1 - 5.8 6.1 8.1 7.8 5.7 8.1 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETS60570.1 - 6.5 7.2 15.8 17 5.9 15.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CAF1C_H4-bd PF12265.8 ETS60571.1 - 5.8e-31 106.6 0.9 1.7e-30 105.1 0.9 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ETS60571.1 - 4.4e-26 90.6 7.7 1.2e-05 26.0 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Na_sulph_symp PF00939.19 ETS60572.1 - 4.5e-30 105.1 37.1 6.4e-30 104.6 37.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ETS60572.1 - 3.1e-28 98.8 31.4 3.1e-28 98.8 31.4 2.2 1 1 1 2 2 2 1 Citrate transporter SPX PF03105.19 ETS60572.1 - 1.9e-25 90.6 40.0 1e-16 61.9 24.4 3.8 2 1 1 3 3 3 2 SPX domain RRN3 PF05327.11 ETS60572.1 - 2.7 6.4 6.2 4.9 5.6 6.2 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ATPase_gene1 PF09527.10 ETS60572.1 - 5.5 7.2 11.4 3.2 8.0 6.1 3.2 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Pro_isomerase PF00160.21 ETS60573.1 - 4e-44 150.7 0.0 8.5e-44 149.6 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD zf-NOSIP PF15906.5 ETS60573.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-ZPR1 PF03367.13 ETS60574.1 - 1.4e-110 366.2 1.0 3.1e-55 186.4 0.0 3.0 2 1 0 2 2 2 2 ZPR1 zinc-finger domain HypA PF01155.19 ETS60574.1 - 0.00022 21.2 2.1 0.087 12.8 0.2 2.4 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 ETS60574.1 - 0.0077 15.6 9.9 3 7.4 0.1 3.5 3 0 0 3 3 3 3 zinc-ribbon domain zinc-ribbons_6 PF07191.12 ETS60574.1 - 0.054 13.5 1.5 3 7.9 0.0 2.6 2 1 0 2 2 2 0 zinc-ribbons DZR PF12773.7 ETS60574.1 - 0.074 13.1 8.4 0.11 12.5 0.2 3.2 2 1 0 2 2 2 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 ETS60574.1 - 0.1 12.6 3.1 6.5 6.8 0.2 2.9 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Cytochrome_C7 PF14522.6 ETS60574.1 - 0.25 11.4 3.1 2.9 8.0 0.9 2.7 2 1 0 2 2 2 0 Cytochrome c7 and related cytochrome c Zn-ribbon_8 PF09723.10 ETS60574.1 - 1 9.6 8.7 21 5.3 0.4 3.7 3 1 0 3 3 3 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 ETS60574.1 - 4.7 7.0 6.6 61 3.5 0.4 3.5 3 0 0 3 3 3 0 Rubredoxin metal binding domain Lar_restr_allev PF14354.6 ETS60574.1 - 4.9 7.6 8.1 4.3 7.8 0.2 3.6 3 1 0 3 3 3 0 Restriction alleviation protein Lar Response_reg PF00072.24 ETS60576.1 - 5.2e-20 71.7 0.0 1.4e-19 70.3 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ETS60576.1 - 2e-15 57.2 0.2 3.7e-15 56.4 0.2 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ETS60576.1 - 1.1e-06 28.6 0.1 3.2e-06 27.1 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 ETS60576.1 - 0.068 13.5 0.1 0.75 10.1 0.0 2.9 4 0 0 4 4 4 0 GAF domain MBF1 PF08523.10 ETS60577.1 - 6.8e-19 68.1 0.1 6.8e-19 68.1 0.1 1.7 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 ETS60577.1 - 8e-15 54.7 0.3 1.4e-14 53.9 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ETS60577.1 - 7.2e-06 26.3 0.0 1.3e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ETS60577.1 - 0.00043 20.2 0.0 0.0011 18.9 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_25 PF13413.6 ETS60577.1 - 0.079 12.8 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain F-box-like PF12937.7 ETS60578.1 - 3.9e-09 36.3 2.8 9.7e-09 35.0 0.3 2.7 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ETS60578.1 - 8.3e-05 22.4 0.5 0.00023 20.9 0.5 1.8 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 ETS60578.1 - 0.0016 19.3 0.6 0.014 16.2 0.6 2.8 1 0 0 1 1 1 1 WD domain, G-beta repeat DEAD PF00270.29 ETS60579.1 - 5.3e-40 137.0 0.0 1e-39 136.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS60579.1 - 1.1e-30 106.2 0.0 1.8e-28 99.1 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS60579.1 - 2.8e-07 30.7 0.0 1.4e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DnaJ-X PF14308.6 ETS60579.1 - 0.0063 16.0 3.0 0.011 15.2 3.0 1.3 1 0 0 1 1 1 1 X-domain of DnaJ-containing AAA_19 PF13245.6 ETS60579.1 - 0.0067 16.8 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain CDK5_activator PF03261.15 ETS60579.1 - 5.3 6.5 5.8 17 4.9 0.1 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein MIF4G PF02854.19 ETS60580.1 - 9.4e-23 81.0 0.0 2.1e-22 79.8 0.0 1.6 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 ETS60580.1 - 1.3e-14 54.2 0.0 4.9e-14 52.3 0.0 2.0 1 1 0 1 1 1 1 MA3 domain WD40 PF00400.32 ETS60581.1 - 2.5e-36 123.0 17.2 8.1e-08 32.8 0.0 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60581.1 - 2.8e-11 43.6 0.1 0.0026 18.0 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS60581.1 - 0.044 12.7 1.2 2.9 6.8 0.1 3.0 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4592 PF15262.6 ETS60581.1 - 0.17 12.6 6.4 0.45 11.2 6.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4592) RRS1 PF04939.12 ETS60582.1 - 1.9e-55 187.2 2.1 1.9e-55 187.2 2.1 1.7 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) kleA_kleC PF17383.2 ETS60582.1 - 4.9 7.5 8.8 8 6.9 1.3 3.2 3 0 0 3 3 3 0 Uncharacterized KorC regulated protein A Amino_oxidase PF01593.24 ETS60584.1 - 1.2e-10 41.3 0.6 6.2e-09 35.7 0.6 2.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS60584.1 - 4.4e-10 39.6 0.0 1.3e-09 38.2 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ETS60584.1 - 0.0023 18.0 0.0 0.41 10.6 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding DAO PF01266.24 ETS60584.1 - 0.051 13.1 0.3 0.23 11.0 0.0 2.2 2 1 1 3 3 3 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS60584.1 - 0.093 11.9 0.0 0.18 11.0 0.0 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FMN_dh PF01070.18 ETS60585.1 - 4.4e-120 400.9 0.3 5.2e-120 400.6 0.3 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ETS60585.1 - 7.6e-20 70.8 0.0 1.9e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ETS60585.1 - 1.5e-05 24.4 0.0 2.3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ETS60585.1 - 0.00012 21.2 0.1 0.00022 20.4 0.1 1.4 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain ThiG PF05690.14 ETS60585.1 - 0.0028 17.0 0.0 0.79 9.0 0.0 2.3 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Vitellogenin_N PF01347.22 ETS60585.1 - 0.046 12.1 0.0 0.064 11.6 0.0 1.1 1 0 0 1 1 1 0 Lipoprotein amino terminal region Arm PF00514.23 ETS60585.1 - 0.048 13.7 0.0 0.25 11.4 0.0 2.2 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat His_biosynth PF00977.21 ETS60585.1 - 0.11 12.0 0.3 0.86 9.0 0.1 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein ATPase PF06745.13 ETS60585.1 - 0.14 11.5 0.0 0.41 10.0 0.0 1.6 2 0 0 2 2 2 0 KaiC NMO PF03060.15 ETS60585.1 - 0.16 11.3 1.6 0.15 11.4 0.3 1.5 2 0 0 2 2 2 0 Nitronate monooxygenase Band_7 PF01145.25 ETS60586.1 - 2e-27 96.3 1.4 2e-27 96.3 1.4 1.3 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ETS60586.1 - 0.064 13.0 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family LRS4 PF10422.9 ETS60586.1 - 0.082 12.5 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 sCache_3_2 PF17203.4 ETS60586.1 - 0.084 13.0 0.9 0.16 12.1 0.8 1.6 1 1 0 1 1 1 0 Single cache domain 3 DUF2605 PF10792.9 ETS60586.1 - 0.61 10.0 2.2 5.5 7.0 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2605) IlvN PF07991.12 ETS60587.1 - 3.7e-43 146.9 0.0 6.3e-43 146.2 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 ETS60587.1 - 3.9e-41 140.7 0.0 6.2e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain F420_oxidored PF03807.17 ETS60587.1 - 0.0025 18.4 0.1 0.0069 16.9 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ETS60587.1 - 0.075 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Methyltransf_11 PF08241.12 ETS60588.1 - 9.4e-21 74.3 0.1 5.7e-20 71.8 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS60588.1 - 9.6e-20 71.1 0.1 5.3e-19 68.7 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS60588.1 - 3.3e-19 69.2 0.0 4.9e-19 68.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS60588.1 - 5.6e-15 55.6 0.0 8.1e-15 55.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS60588.1 - 4e-14 53.1 0.0 7.3e-14 52.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETS60588.1 - 6.5e-11 42.0 0.0 9.3e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NodS PF05401.11 ETS60588.1 - 0.00032 20.4 0.0 0.0014 18.3 0.0 1.9 1 1 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 ETS60588.1 - 0.00064 19.3 0.0 0.044 13.3 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 ETS60588.1 - 0.011 15.4 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.15 ETS60588.1 - 0.057 13.3 0.0 3.9 7.3 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase PrmA PF06325.13 ETS60588.1 - 0.075 12.4 0.1 0.6 9.5 0.1 2.4 1 1 1 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_29 PF03141.16 ETS60588.1 - 0.11 11.0 0.0 2.9 6.3 0.0 2.0 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_32 PF13679.6 ETS60588.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain GST_N_3 PF13417.6 ETS60589.1 - 1.1e-11 45.0 0.0 2.3e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETS60589.1 - 2.8e-08 33.7 0.0 1.3e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ETS60589.1 - 2e-06 28.0 0.0 3.9e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ETS60589.1 - 3.2e-06 27.2 0.0 2.7e-05 24.3 0.0 2.5 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS60589.1 - 2.8e-05 24.2 0.0 7.7e-05 22.8 0.0 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETS60589.1 - 4.6e-05 23.7 0.0 0.0001 22.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 ETS60589.1 - 0.0013 19.2 0.0 0.004 17.7 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.13 ETS60589.1 - 0.039 13.8 0.0 0.086 12.7 0.0 1.6 1 1 0 1 1 1 0 Glutaredoxin 2, C terminal domain Peptidase_M24 PF00557.24 ETS60590.1 - 7.9e-49 166.2 0.0 1.1e-48 165.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ETS60590.1 - 8.2e-41 138.6 0.0 1.5e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Snf7 PF03357.21 ETS60592.1 - 2.1e-34 118.6 8.9 2.6e-34 118.3 8.9 1.0 1 0 0 1 1 1 1 Snf7 TIP39 PF14980.6 ETS60592.1 - 0.12 12.3 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 TIP39 peptide PPR_2 PF13041.6 ETS60593.1 - 1.7e-44 149.8 0.1 1.9e-08 34.4 0.0 7.8 7 1 1 8 8 8 7 PPR repeat family PPR_1 PF12854.7 ETS60593.1 - 1.9e-27 94.7 0.5 0.011 15.5 0.0 10.1 11 0 0 11 11 11 7 PPR repeat PPR_3 PF13812.6 ETS60593.1 - 2.6e-20 72.2 0.0 4.5e-06 26.6 0.0 6.4 6 1 2 8 8 8 6 Pentatricopeptide repeat domain PPR PF01535.20 ETS60593.1 - 4.2e-18 64.2 11.9 0.00056 20.0 0.1 11.4 12 0 0 12 12 12 3 PPR repeat PPR_long PF17177.4 ETS60593.1 - 2.1e-10 40.4 1.8 0.35 10.2 0.0 4.8 1 1 2 4 4 4 4 Pentacotripeptide-repeat region of PRORP MNE1 PF13762.6 ETS60593.1 - 0.1 12.6 0.0 8.9 6.3 0.0 2.8 3 0 0 3 3 3 0 Mitochondrial splicing apparatus component TPR_19 PF14559.6 ETS60593.1 - 0.23 12.0 5.9 3.8 8.1 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat RIO1 PF01163.22 ETS60594.1 - 9.7e-05 22.0 0.3 0.00017 21.3 0.3 1.4 1 0 0 1 1 1 1 RIO1 family SDA1 PF05285.12 ETS60594.1 - 0.008 15.7 17.5 0.0096 15.4 17.5 1.1 1 0 0 1 1 1 1 SDA1 NOA36 PF06524.12 ETS60594.1 - 0.046 13.0 11.0 0.069 12.5 11.0 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETS60594.1 - 0.13 10.5 15.8 0.16 10.2 15.8 1.2 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 ETS60594.1 - 0.16 11.6 14.1 0.25 11.0 14.1 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DNA_pol_phi PF04931.13 ETS60594.1 - 0.21 9.6 17.1 0.27 9.3 17.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETS60594.1 - 0.72 8.1 15.3 0.89 7.8 15.3 1.1 1 0 0 1 1 1 0 CDC45-like protein COPI_C PF06957.11 ETS60594.1 - 0.81 8.4 5.0 1 8.0 5.0 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus SpoIIIAH PF12685.7 ETS60594.1 - 1.3 8.8 11.3 1.8 8.3 11.3 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein RPN2_C PF18004.1 ETS60594.1 - 1.6 8.7 13.1 5.1 7.0 0.5 2.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain PI3K_1B_p101 PF10486.9 ETS60594.1 - 2 6.1 6.0 2.2 6.0 6.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Nucleo_P87 PF07267.11 ETS60594.1 - 2.5 6.9 6.8 3.2 6.5 6.8 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TRAP_alpha PF03896.16 ETS60594.1 - 2.6 7.2 5.9 3.8 6.6 5.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PPP4R2 PF09184.11 ETS60594.1 - 3.5 7.1 12.0 4.8 6.7 12.0 1.3 1 0 0 1 1 1 0 PPP4R2 YL1 PF05764.13 ETS60594.1 - 7.3 6.6 23.7 6.7 6.7 22.4 1.4 1 1 0 1 1 1 0 YL1 nuclear protein DUF4097 PF13349.6 ETS60595.1 - 0.00047 19.6 0.5 0.0014 18.0 0.5 1.8 1 1 0 1 1 1 1 Putative adhesin DDE_1 PF03184.19 ETS60596.1 - 1.4e-21 76.9 0.0 2.3e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 ETS60596.1 - 6e-09 35.8 0.0 1.4e-08 34.6 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain SAICAR_synt PF01259.18 ETS60597.1 - 3.4e-94 315.2 0.0 4.1e-94 314.9 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Kinesin PF00225.23 ETS60598.1 - 7.2e-108 360.4 0.6 1.9e-107 359.1 0.6 1.7 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETS60598.1 - 1.8e-24 86.4 0.2 6.5e-24 84.6 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding DHquinase_II PF01220.19 ETS60598.1 - 0.07 12.8 2.0 0.18 11.5 0.9 2.3 2 0 0 2 2 2 0 Dehydroquinase class II MitMem_reg PF13012.6 ETS60598.1 - 0.1 13.0 0.0 0.1 13.0 0.0 3.9 2 2 0 3 3 3 0 Maintenance of mitochondrial structure and function AAA_22 PF13401.6 ETS60598.1 - 3.5 7.9 5.6 23 5.3 0.0 4.3 2 1 1 3 3 3 0 AAA domain DUF1295 PF06966.12 ETS60599.1 - 3.7e-37 128.1 3.6 6.2e-36 124.1 3.6 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) WD40 PF00400.32 ETS60600.1 - 4.5e-49 163.4 15.6 1.3e-11 44.8 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60600.1 - 6.1e-19 68.1 1.3 5.2e-06 26.7 0.0 5.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETS60600.1 - 5.3e-12 46.0 2.0 3.4e-06 27.1 0.2 3.3 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETS60600.1 - 2.2e-10 40.0 5.5 0.13 11.2 0.1 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETS60600.1 - 1.3e-09 37.2 14.3 0.0043 15.8 0.1 5.6 1 1 5 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETS60600.1 - 3.2e-05 23.4 0.0 0.13 11.5 0.0 3.1 1 1 1 3 3 3 3 WD40-like domain Coatomer_WDAD PF04053.14 ETS60600.1 - 0.00016 20.9 0.1 0.29 10.1 0.1 2.2 2 0 0 2 2 2 2 Coatomer WD associated region Frtz PF11768.8 ETS60600.1 - 0.0013 17.1 0.2 0.019 13.3 0.0 2.3 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 ETS60600.1 - 0.03 14.0 3.8 0.14 11.8 0.1 3.4 4 0 0 4 4 4 0 TUP1-like enhancer of split RNA_pol_Rpb4 PF03874.16 ETS60601.1 - 3.3e-11 43.6 1.0 1.1e-10 41.9 1.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb4 Rhomboid PF01694.22 ETS60602.1 - 1.2e-13 51.3 14.9 3.4e-13 49.9 14.9 1.7 1 1 0 1 1 1 1 Rhomboid family GHMP_kinases_N PF00288.26 ETS60602.1 - 0.18 12.1 1.5 0.55 10.5 1.5 1.9 1 0 0 1 1 1 0 GHMP kinases N terminal domain Fasciclin PF02469.22 ETS60604.1 - 3.8e-33 114.4 3.2 7.2e-23 81.2 0.5 2.3 2 0 0 2 2 2 2 Fasciclin domain Serglycin PF04360.12 ETS60604.1 - 0.046 13.7 3.6 0.12 12.4 3.6 1.7 1 0 0 1 1 1 0 Serglycin GST_N_3 PF13417.6 ETS60605.1 - 8.8e-14 51.7 0.0 1.6e-13 50.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ETS60605.1 - 1.3e-10 41.4 0.1 2.3e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETS60605.1 - 4e-10 39.8 0.0 7.2e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 ETS60605.1 - 0.00046 20.3 0.0 0.0008 19.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_C_2 PF13410.6 ETS60605.1 - 0.011 15.7 0.1 0.02 14.9 0.1 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS60605.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Cupin_1 PF00190.22 ETS60606.1 - 4.3e-37 127.0 0.0 2.3e-18 66.2 0.1 2.3 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 ETS60606.1 - 7.4e-24 83.3 0.6 2.8e-13 49.4 0.2 2.4 2 0 0 2 2 2 2 Cupin domain AraC_binding PF02311.19 ETS60606.1 - 1.8e-12 47.3 0.0 4.5e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 AraC-like ligand binding domain Cupin_3 PF05899.12 ETS60606.1 - 6.8e-06 25.7 0.0 0.02 14.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 ETS60606.1 - 3.1e-05 23.9 0.0 0.019 14.8 0.0 2.3 2 0 0 2 2 2 2 Mannose-6-phosphate isomerase ARD PF03079.14 ETS60606.1 - 0.0087 16.2 0.0 0.31 11.2 0.0 2.3 2 0 0 2 2 2 1 ARD/ARD' family Ectoine_synth PF06339.12 ETS60606.1 - 0.015 15.5 0.0 0.074 13.2 0.0 1.9 2 0 0 2 2 2 0 Ectoine synthase 3-HAO PF06052.12 ETS60606.1 - 0.057 13.1 0.0 12 5.5 0.0 2.3 2 0 0 2 2 2 0 3-hydroxyanthranilic acid dioxygenase adh_short PF00106.25 ETS60607.1 - 8.3e-36 123.3 2.3 1.4e-35 122.5 2.3 1.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60607.1 - 7.2e-26 91.2 1.8 9.7e-26 90.8 1.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS60607.1 - 3.2e-12 46.7 1.4 4.6e-12 46.2 1.4 1.2 1 0 0 1 1 1 1 KR domain LigB PF02900.18 ETS60607.1 - 0.066 12.3 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase V-ATPase_C PF03223.15 ETS60608.1 - 4.2e-128 427.9 0.9 4.7e-128 427.7 0.9 1.0 1 0 0 1 1 1 1 V-ATPase subunit C DUF4110 PF13422.6 ETS60608.1 - 0.0084 16.2 1.2 0.025 14.6 1.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4110) DUF4404 PF14357.6 ETS60608.1 - 3.6 8.3 5.9 28 5.4 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) PTS_2-RNA PF01885.16 ETS60609.1 - 4.7e-65 219.0 0.0 6.2e-65 218.6 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family DUF4228 PF14009.6 ETS60609.1 - 0.21 11.9 5.1 0.32 11.4 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) tRNA_int_end_N2 PF12928.7 ETS60610.1 - 1.5e-21 76.3 0.0 3e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 ETS60610.1 - 0.013 15.2 0.3 0.045 13.4 0.0 1.9 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain SBP_bac_1 PF01547.25 ETS60610.1 - 0.14 12.1 0.4 0.32 10.9 0.4 1.5 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein CMAS PF02353.20 ETS60611.1 - 4.5e-35 121.3 4.0 9.4e-35 120.2 4.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ETS60611.1 - 3e-14 53.5 0.0 9.6e-14 51.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS60611.1 - 9.5e-13 48.6 0.0 2.7e-12 47.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS60611.1 - 1.4e-11 44.4 0.0 5.6e-11 42.5 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS60611.1 - 1.2e-10 41.5 0.3 2.9e-10 40.2 0.3 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS60611.1 - 8.1e-08 32.0 0.0 1.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ETS60611.1 - 1.2e-07 32.4 0.0 3.2e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 ETS60611.1 - 8.4e-05 22.1 0.0 0.00016 21.1 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_4 PF02390.17 ETS60611.1 - 0.00057 19.4 0.0 0.0012 18.4 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltr_RsmB-F PF01189.17 ETS60611.1 - 0.0031 17.2 0.1 0.0067 16.1 0.0 1.5 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F MetW PF07021.12 ETS60611.1 - 0.033 13.8 0.0 0.066 12.8 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 ETS60611.1 - 0.038 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_17 PF12692.7 ETS60611.1 - 0.12 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase ArAE_2 PF10334.9 ETS60612.1 - 9.9e-60 202.2 0.0 2e-59 201.2 0.0 1.5 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 ETS60612.1 - 1.9e-41 142.6 7.5 8.6e-37 127.3 1.3 3.3 3 0 0 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 ETS60612.1 - 2.6e-10 40.5 13.7 2.6e-10 40.5 13.7 3.3 3 0 0 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.8 ETS60612.1 - 0.11 11.3 3.4 0.24 10.2 3.4 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter UBX PF00789.20 ETS60613.1 - 4.6e-07 29.9 0.0 7.3e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 UBX domain Pec_lyase_C PF00544.19 ETS60614.1 - 9.3e-17 61.3 1.2 1.3e-15 57.6 1.2 2.3 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 ETS60614.1 - 5.1e-05 23.2 1.8 0.0003 20.7 1.9 1.9 1 1 0 1 1 1 1 Right handed beta helix region Nop53 PF07767.11 ETS60614.1 - 2.3 7.5 32.3 3.6 6.9 32.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RR_TM4-6 PF06459.12 ETS60614.1 - 3.7 7.3 25.1 6 6.6 25.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Asparaginase_2 PF01112.18 ETS60615.1 - 1.2e-62 211.7 1.9 7.4e-50 169.7 0.1 2.2 2 0 0 2 2 2 2 Asparaginase NAT PF04768.13 ETS60618.1 - 4.2e-32 111.1 0.2 2.8e-20 72.6 0.0 2.2 2 0 0 2 2 2 2 NAT, N-acetyltransferase, of N-acetylglutamate synthase Barstar PF01337.18 ETS60618.1 - 0.085 12.9 0.0 0.42 10.7 0.0 2.2 1 0 0 1 1 1 0 Barstar (barnase inhibitor) PMM PF03332.13 ETS60619.1 - 8.4e-99 329.8 0.6 1.7e-98 328.8 0.6 1.5 1 1 0 1 1 1 1 Eukaryotic phosphomannomutase Mre11_DNA_bind PF04152.14 ETS60619.1 - 1.1e-45 156.0 0.0 1.1e-45 156.0 0.0 2.2 3 0 0 3 3 3 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 ETS60619.1 - 9.5e-13 49.1 0.1 3e-12 47.5 0.1 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETS60619.1 - 2.2e-05 24.7 0.2 0.0007 19.8 0.2 3.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Hydrolase_3 PF08282.12 ETS60619.1 - 0.0029 17.4 0.0 0.035 13.8 0.0 2.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cyto_heme_lyase PF01265.17 ETS60620.1 - 1.7e-33 116.5 16.7 1.9e-29 103.2 16.7 4.1 2 1 0 2 2 2 2 Cytochrome c/c1 heme lyase Rcd1 PF04078.13 ETS60621.1 - 1.8e-123 410.9 2.4 2.1e-123 410.7 2.4 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Peptidase_M76 PF09768.9 ETS60622.1 - 8.7e-68 227.4 0.3 1e-67 227.2 0.3 1.0 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 ETS60622.1 - 0.0013 18.6 1.1 0.0034 17.2 0.3 1.9 1 1 1 2 2 2 1 SprT-like family Abhydrolase_1 PF00561.20 ETS60623.1 - 7.2e-16 58.6 0.3 1.3e-10 41.3 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS60623.1 - 1.2e-15 57.4 0.0 1.2e-08 34.5 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 ETS60623.1 - 6e-05 22.7 0.0 0.00045 19.8 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ETS60623.1 - 6.2e-05 23.7 0.9 0.00012 22.8 0.9 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family AXE1 PF05448.12 ETS60623.1 - 0.00053 18.7 0.1 0.029 13.0 0.0 2.5 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 ETS60623.1 - 0.0013 18.4 0.0 0.02 14.5 0.0 2.1 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETS60623.1 - 0.0044 16.5 0.0 0.61 9.5 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family BAAT_C PF08840.11 ETS60623.1 - 0.007 16.3 0.0 0.28 11.1 0.0 2.5 3 0 0 3 3 3 1 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 ETS60623.1 - 0.0074 16.0 0.0 0.015 15.0 0.0 1.7 2 0 0 2 2 2 1 Serine hydrolase (FSH1) DUF818 PF05677.12 ETS60623.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Esterase PF00756.20 ETS60623.1 - 0.16 11.6 0.1 0.28 10.8 0.1 1.4 1 1 0 1 1 1 0 Putative esterase ADH_zinc_N PF00107.26 ETS60624.1 - 3.1e-21 75.7 0.5 5.2e-21 75.0 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS60624.1 - 3e-19 68.9 2.6 6.6e-19 67.8 1.1 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain Glu_dehyd_C PF16912.5 ETS60624.1 - 1.5e-05 24.6 0.1 2.3e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ETS60624.1 - 0.012 16.7 0.0 0.02 15.9 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding dehydrogenase AA_permease_2 PF13520.6 ETS60626.1 - 8.4e-50 169.8 53.9 1.1e-49 169.4 53.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS60626.1 - 5.8e-25 87.8 50.4 8e-25 87.4 50.4 1.1 1 0 0 1 1 1 1 Amino acid permease Ntox22 PF15527.6 ETS60627.1 - 0.066 13.3 2.7 0.078 13.0 2.7 1.1 1 0 0 1 1 1 0 Bacterial toxin 22 OapA_N PF08525.11 ETS60627.1 - 0.25 11.3 0.8 0.73 9.8 0.0 2.2 2 0 0 2 2 2 0 Opacity-associated protein A N-terminal motif Fungal_trans PF04082.18 ETS60628.1 - 2.1e-22 79.4 0.0 3.9e-22 78.6 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain PrpF PF04303.13 ETS60629.1 - 6.1e-86 288.7 0.1 1.1e-85 287.8 0.1 1.3 1 1 0 1 1 1 1 PrpF protein Mito_carr PF00153.27 ETS60630.1 - 2.3e-59 197.3 12.3 4e-22 77.9 0.3 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF4574 PF15141.6 ETS60630.1 - 0.052 13.5 0.3 3.2 7.7 0.1 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Tim17 PF02466.19 ETS60630.1 - 1.9 8.9 18.1 0.85 10.0 7.3 2.9 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Sugar_tr PF00083.24 ETS60631.1 - 1.3e-75 255.0 13.2 1.9e-75 254.4 13.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS60631.1 - 1.9e-20 73.1 26.0 1.1e-12 47.6 9.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ECH_1 PF00378.20 ETS60634.1 - 4.8e-37 127.6 0.0 9.8e-33 113.5 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS60634.1 - 2.6e-13 50.2 0.1 1.6e-11 44.3 0.1 2.3 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ADH_zinc_N PF00107.26 ETS60635.1 - 4e-19 68.9 0.1 8.3e-19 67.9 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS60635.1 - 1.5e-13 52.0 0.0 1.8e-12 48.5 0.0 2.2 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS60635.1 - 2.2e-07 30.7 0.0 5.7e-06 26.2 0.0 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Cupin_8 PF13621.6 ETS60636.1 - 0.01 15.6 0.0 0.051 13.3 0.0 1.9 1 1 0 1 1 1 0 Cupin-like domain Cupin_2 PF07883.11 ETS60636.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Cupin domain DDE_3 PF13358.6 ETS60637.1 - 3.6e-15 56.0 0.0 5.7e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 ETS60637.1 - 1.1e-11 44.8 3.9 1.1e-11 44.8 3.9 2.1 2 0 0 2 2 2 1 Transposase HTH_32 PF13565.6 ETS60637.1 - 0.4 11.3 7.8 0.28 11.8 0.8 2.7 2 0 0 2 2 2 0 Homeodomain-like domain p450 PF00067.22 ETS60641.1 - 6.8e-41 140.5 0.0 1.1e-40 139.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 TauD PF02668.16 ETS60642.1 - 3.9e-50 171.1 0.1 4.7e-50 170.9 0.1 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family ADH_zinc_N PF00107.26 ETS60643.1 - 3.1e-10 40.1 0.0 5.6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS60643.1 - 3.5e-06 28.1 0.0 9e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS60643.1 - 4.2e-06 26.6 0.1 6.7e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Peptidase_C48 PF02902.19 ETS60644.1 - 6.2e-21 75.2 0.0 8.9e-21 74.7 0.0 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Phage_integrase PF00589.22 ETS60645.1 - 0.0082 16.0 0.4 0.016 15.0 0.4 1.4 1 0 0 1 1 1 1 Phage integrase family DUF4246 PF14033.6 ETS60646.1 - 8.1e-175 582.3 0.0 9.8e-175 582.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ETS60646.1 - 0.013 15.9 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase Peptidase_M48_N PF16491.5 ETS60648.1 - 3.5e-62 209.5 6.8 3.5e-62 209.5 6.8 1.6 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 ETS60648.1 - 1.8e-32 112.7 0.8 1.3e-30 106.7 0.8 2.8 1 1 0 1 1 1 1 Peptidase family M48 SprT-like PF10263.9 ETS60648.1 - 0.012 15.5 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 SprT-like family Peptidase_M56 PF05569.11 ETS60648.1 - 0.017 14.3 0.0 0.017 14.3 0.0 2.9 4 0 0 4 4 4 0 BlaR1 peptidase M56 Fungal_trans PF04082.18 ETS60649.1 - 1.1e-41 142.6 0.1 1.9e-41 141.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ETS60649.1 - 3e-08 33.7 10.6 0.00091 19.6 1.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS60649.1 - 5.2e-05 23.7 11.0 0.022 15.5 1.1 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger NOA36 PF06524.12 ETS60649.1 - 0.0028 17.0 11.9 0.0044 16.4 11.9 1.2 1 0 0 1 1 1 1 NOA36 protein zf-H2C2_2 PF13465.6 ETS60649.1 - 1.5 9.4 5.0 0.89 10.1 1.3 2.4 2 0 0 2 2 2 0 Zinc-finger double domain SpoIIE PF07228.12 ETS60650.1 - 2.3e-06 27.7 0.1 0.55 10.1 0.0 3.3 3 0 0 3 3 3 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ETS60650.1 - 8.3e-05 22.3 0.4 0.0004 20.1 0.4 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 ETS60650.1 - 0.00032 20.4 0.0 0.021 14.5 0.0 2.6 2 0 0 2 2 2 1 Protein phosphatase 2C Cu-oxidase_3 PF07732.15 ETS60651.1 - 3.3e-38 130.4 3.8 3.3e-37 127.1 1.0 3.4 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ETS60651.1 - 4e-36 123.8 7.5 3.1e-30 104.7 0.3 4.1 3 1 0 3 3 3 3 Multicopper oxidase Cu-oxidase PF00394.22 ETS60651.1 - 1.8e-33 115.9 0.1 3.1e-32 111.9 0.0 2.5 2 0 0 2 2 2 1 Multicopper oxidase Phosphoesterase PF04185.14 ETS60653.1 - 5.2e-26 91.7 3.2 2.1e-25 89.7 3.1 1.8 1 1 0 1 1 1 1 Phosphoesterase family Fer4_12 PF13353.6 ETS60654.1 - 0.00032 21.0 0.0 0.00053 20.3 0.0 1.3 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 ETS60654.1 - 0.021 14.9 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Radical_SAM PF04055.21 ETS60654.1 - 0.038 14.4 0.0 0.095 13.1 0.0 1.7 1 1 0 1 1 1 0 Radical SAM superfamily Fer2 PF00111.27 ETS60655.1 - 7.6e-08 32.2 0.9 7.6e-08 32.2 0.9 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DZR PF12773.7 ETS60655.1 - 6.1 7.0 9.0 0.77 9.8 2.8 2.5 3 0 0 3 3 3 0 Double zinc ribbon zf-C2H2 PF00096.26 ETS60656.1 - 7.5e-06 26.1 13.4 0.0011 19.3 3.3 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS60656.1 - 0.00087 19.9 13.8 0.0066 17.2 2.2 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETS60656.1 - 0.0042 17.4 3.3 0.0042 17.4 3.3 3.4 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 ETS60656.1 - 0.4 11.0 3.6 1.3 9.4 3.6 1.8 1 0 0 1 1 1 0 C2H2-type zinc ribbon GTP_EFTU PF00009.27 ETS60657.1 - 3.5e-58 196.4 0.1 6.3e-58 195.5 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ETS60657.1 - 7e-37 125.9 0.1 2.6e-36 124.1 0.1 2.1 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 ETS60657.1 - 4e-31 106.9 0.0 1e-30 105.7 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ETS60657.1 - 2.9e-22 78.5 0.2 6.9e-22 77.3 0.2 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETS60657.1 - 1.6e-13 50.8 0.0 4e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ETS60657.1 - 5.2e-07 29.5 0.0 1.2e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain adh_short_C2 PF13561.6 ETS60657.1 - 0.03 13.9 0.6 0.083 12.4 0.6 1.7 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase SKN1 PF03935.15 ETS60658.1 - 9.3e-182 604.9 1.7 1.2e-181 604.6 1.7 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) SKN1 PF03935.15 ETS60660.1 - 3.6e-190 632.6 5.1 4.2e-190 632.4 5.1 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 ETS60660.1 - 1e-06 28.4 0.3 0.0044 16.5 0.0 2.7 2 1 0 2 2 2 2 Glycosyl hydrolases family 16 Rot1 PF10681.9 ETS60661.1 - 2e-46 158.1 0.1 2.5e-46 157.9 0.1 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal SKN1 PF03935.15 ETS60663.1 - 1.3e-183 611.0 0.3 1.5e-183 610.8 0.3 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) FMO-like PF00743.19 ETS60664.1 - 2.1e-13 49.5 0.0 6.6e-12 44.6 0.0 2.3 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETS60664.1 - 5.2e-13 48.9 0.0 2.7e-08 33.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETS60664.1 - 1.2e-10 41.1 0.0 8e-09 35.1 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 ETS60664.1 - 3.1e-09 36.5 0.0 3.9e-05 23.1 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS60664.1 - 0.0061 16.5 0.0 4.4 7.3 0.0 3.9 4 0 0 4 4 4 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 ETS60664.1 - 0.015 15.6 0.5 0.17 12.1 0.0 2.8 3 0 0 3 3 3 0 NAD(P)-binding Rossmann-like domain AMP-binding PF00501.28 ETS60665.1 - 5.3e-82 275.7 0.0 6.8e-82 275.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS60665.1 - 5.9e-13 49.6 0.0 1.5e-12 48.3 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TAFII28 PF04719.14 ETS60666.1 - 1.6e-25 89.0 2.1 1.2e-22 79.8 2.1 2.4 1 1 0 1 1 1 1 hTAFII28-like protein conserved region Sacchrp_dh_C PF16653.5 ETS60667.1 - 5.2e-91 305.4 0.0 8.2e-91 304.8 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Spermine_synth PF01564.17 ETS60667.1 - 1.3e-65 220.4 0.0 2.6e-65 219.4 0.0 1.5 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Sacchrp_dh_NADP PF03435.18 ETS60667.1 - 4.5e-25 88.4 0.4 1.5e-24 86.7 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Spermine_synt_N PF17284.2 ETS60667.1 - 4.3e-23 81.0 0.1 7.8e-23 80.1 0.1 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 ETS60667.1 - 0.00066 20.3 0.0 0.0047 17.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain NAD_binding_10 PF13460.6 ETS60667.1 - 0.0045 16.9 0.0 0.0076 16.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ETS60667.1 - 0.017 15.6 0.0 0.076 13.5 0.0 2.2 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ETS60667.1 - 0.029 14.4 0.1 0.12 12.4 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 ETS60667.1 - 0.029 13.4 0.0 0.048 12.7 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_12 PF08242.12 ETS60667.1 - 0.032 15.0 0.1 0.26 12.1 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain Zn_clus PF00172.18 ETS60670.1 - 6.8e-05 22.9 14.3 0.0001 22.4 14.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-K PF11802.8 ETS60671.1 - 1.6e-11 44.3 15.8 1.9e-09 37.5 11.8 3.1 1 1 1 2 2 2 1 Centromere-associated protein K FeoC PF09012.10 ETS60671.1 - 0.0074 16.3 0.1 0.045 13.8 0.0 2.2 2 0 0 2 2 2 1 FeoC like transcriptional regulator ResIII PF04851.15 ETS60672.1 - 1.8e-23 83.4 0.0 3.6e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETS60672.1 - 1.3e-15 57.7 0.0 9.7e-15 54.9 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS60672.1 - 4.1e-12 46.2 0.0 7.6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 ETS60672.1 - 0.0013 17.9 0.0 0.0026 16.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 ETS60672.1 - 0.0031 16.8 0.1 0.01 15.1 0.0 1.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) SWI2_SNF2 PF18766.1 ETS60672.1 - 0.009 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 ETS60672.1 - 0.0092 16.3 0.0 0.046 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain ERCC3_RAD25_C PF16203.5 ETS60672.1 - 0.012 14.8 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase cobW PF02492.19 ETS60672.1 - 0.018 14.6 0.0 0.032 13.8 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_11 PF13086.6 ETS60672.1 - 0.054 13.3 1.3 4.6 6.9 0.0 3.0 2 1 1 3 3 3 0 AAA domain SNF2_N PF00176.23 ETS60672.1 - 0.058 12.1 0.1 0.13 10.9 0.0 1.5 2 0 0 2 2 2 0 SNF2 family N-terminal domain Pkinase PF00069.25 ETS60675.1 - 6.2e-75 252.0 0.0 8.2e-75 251.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60675.1 - 1.9e-36 125.7 0.0 2.9e-36 125.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 ETS60675.1 - 2.5e-19 69.8 0.0 2e-09 37.9 0.0 3.4 3 0 0 3 3 3 2 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 ETS60675.1 - 3.2e-08 33.2 0.0 4.9e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like UBA_2 PF08587.11 ETS60675.1 - 2.7e-05 24.2 0.2 5.7e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) RIO1 PF01163.22 ETS60675.1 - 0.0046 16.6 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ETS60675.1 - 0.07 12.1 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Period_C PF12114.8 ETS60675.1 - 1.5 8.4 8.6 0.36 10.4 0.2 2.5 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Tubulin PF00091.25 ETS60676.1 - 2.3e-69 233.6 0.0 3.6e-69 232.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETS60676.1 - 1.1e-41 142.0 0.2 1.7e-41 141.3 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETS60676.1 - 2.9e-07 30.8 0.0 7.4e-07 29.5 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ETS60676.1 - 0.0053 16.0 0.0 0.011 14.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 ETS60676.1 - 0.038 13.7 0.0 0.087 12.5 0.0 1.6 1 0 0 1 1 1 0 Tubulin domain Mago_nashi PF02792.14 ETS60677.1 - 1.9e-75 251.7 0.1 2.1e-75 251.6 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein DRY_EERY PF09750.9 ETS60678.1 - 0.0068 16.7 0.1 0.0068 16.7 0.1 2.1 2 1 0 2 2 2 1 Alternative splicing regulator Surp PF01805.20 ETS60678.1 - 0.033 14.2 0.4 0.061 13.3 0.0 1.6 2 0 0 2 2 2 0 Surp module Cpn60_TCP1 PF00118.24 ETS60679.1 - 1.3e-85 287.9 9.6 2.3e-85 287.1 9.6 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn10 PF00166.21 ETS60680.1 - 9.3e-27 92.9 0.0 1.1e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Actin PF00022.19 ETS60681.1 - 3.9e-37 127.8 0.0 6.2e-34 117.3 0.0 3.5 2 1 0 2 2 2 2 Actin ThiF PF00899.21 ETS60682.1 - 1.9e-14 53.7 0.0 4.2e-14 52.5 0.0 1.5 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 ETS60682.1 - 0.0018 18.5 0.1 0.016 15.4 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle SMC_N PF02463.19 ETS60683.1 - 4.3e-67 225.8 0.0 1.1e-66 224.4 0.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ETS60683.1 - 9.7e-21 74.3 2.5 1.3e-20 73.9 0.4 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ETS60683.1 - 3.2e-10 40.3 9.1 0.00012 22.1 0.0 3.8 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Spc7 PF08317.11 ETS60683.1 - 2.5e-06 26.6 31.2 1.4e-05 24.2 14.3 6.5 3 2 3 6 6 6 4 Spc7 kinetochore protein AAA_23 PF13476.6 ETS60683.1 - 5.5e-06 27.0 37.4 5.5e-06 27.0 37.4 6.2 2 2 0 2 2 1 1 AAA domain Fez1 PF06818.15 ETS60683.1 - 6.8e-06 26.7 87.3 8.1e-06 26.4 14.8 5.4 2 2 3 5 5 5 3 Fez1 AAA_15 PF13175.6 ETS60683.1 - 1.2e-05 25.2 7.1 1.2e-05 25.2 7.1 3.5 2 2 1 3 3 2 1 AAA ATPase domain AAA_29 PF13555.6 ETS60683.1 - 0.00011 21.9 0.1 0.00072 19.2 0.0 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ETS60683.1 - 0.04 14.4 0.0 0.04 14.4 0.0 6.3 5 1 0 6 6 6 0 ABC transporter Filament PF00038.21 ETS60683.1 - 0.084 12.4 74.7 0.034 13.7 17.2 7.0 2 2 3 6 6 6 0 Intermediate filament protein HIP1_clath_bdg PF16515.5 ETS60683.1 - 0.88 10.2 94.6 0.082 13.5 6.9 9.7 6 3 3 9 9 8 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PhoU PF01895.19 ETS60683.1 - 1.1 9.8 19.8 1.7 9.1 1.8 4.9 4 0 0 4 4 4 0 PhoU domain Pirin PF02678.16 ETS60684.1 - 4.5e-30 103.8 1.6 1.4e-29 102.2 0.6 2.0 2 0 0 2 2 2 1 Pirin Cupin_2 PF07883.11 ETS60684.1 - 6.3e-09 35.4 0.7 2.7e-07 30.2 0.4 2.7 2 0 0 2 2 2 1 Cupin domain Pirin_C_2 PF17954.1 ETS60684.1 - 0.14 12.3 0.7 1.2 9.4 0.1 2.4 3 0 0 3 3 3 0 Quercetinase C-terminal cupin domain AAA_2 PF07724.14 ETS60685.1 - 1.9e-33 116.0 0.0 8.1e-33 113.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 ETS60685.1 - 7.5e-13 49.0 0.0 1.5e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS60685.1 - 5.6e-06 26.7 0.0 3.9e-05 23.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 ETS60685.1 - 1.1e-05 24.7 0.0 2e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain AAA_5 PF07728.14 ETS60685.1 - 3.5e-05 23.8 0.0 8.3e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 ETS60685.1 - 0.00016 21.7 0.0 0.89 9.7 0.0 2.7 2 0 0 2 2 2 2 C-terminal, D2-small domain, of ClpB protein AAA_16 PF13191.6 ETS60685.1 - 0.00018 21.9 1.0 0.0015 18.9 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 ETS60685.1 - 0.0011 19.2 0.0 0.0055 16.9 0.0 2.3 2 0 0 2 2 1 1 AAA domain ABC_tran PF00005.27 ETS60685.1 - 0.0029 18.1 0.0 0.0077 16.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 ETS60685.1 - 0.0062 16.5 0.0 0.029 14.3 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 ETS60685.1 - 0.02 14.9 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ETS60685.1 - 0.025 14.0 0.0 0.19 11.1 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 ETS60685.1 - 0.027 13.8 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 ETS60685.1 - 0.037 13.7 0.0 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETS60685.1 - 0.056 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_21 PF13304.6 ETS60685.1 - 0.061 13.1 0.0 0.14 12.0 0.0 1.6 2 0 0 2 2 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETS60685.1 - 0.064 13.0 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 ETS60685.1 - 0.087 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 ETS60685.1 - 0.095 12.4 0.0 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 ETS60685.1 - 0.098 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 ETS60685.1 - 0.098 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETS60685.1 - 0.13 12.8 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETS60685.1 - 0.13 12.7 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETS60685.1 - 0.15 11.6 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 ETS60685.1 - 0.2 11.0 0.0 0.4 10.1 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DNA_ligase_A_M PF01068.21 ETS60686.1 - 9.9e-58 195.1 0.0 1.7e-57 194.4 0.0 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ETS60686.1 - 2.2e-45 155.1 0.1 3.8e-45 154.3 0.1 1.4 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ETS60686.1 - 1e-23 83.8 0.0 3e-23 82.3 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 ETS60686.1 - 0.0017 18.7 0.0 0.003 17.9 0.0 1.4 1 0 0 1 1 1 1 RNA ligase GP67 PF17634.2 ETS60686.1 - 0.02 15.3 5.0 0.075 13.5 5.0 2.0 1 0 0 1 1 1 0 Gene product 67 DNA_ligase_OB_2 PF14743.6 ETS60686.1 - 0.042 13.9 0.2 5.6 7.1 0.0 2.6 2 0 0 2 2 2 0 DNA ligase OB-like domain eIF-3c_N PF05470.12 ETS60686.1 - 0.11 10.8 0.1 0.17 10.1 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus TrmB PF01978.19 ETS60686.1 - 0.12 12.3 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB ORC6 PF05460.13 ETS60686.1 - 0.19 11.0 10.4 0.33 10.2 10.4 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) NOA36 PF06524.12 ETS60686.1 - 8.3 5.6 6.7 15 4.8 6.7 1.4 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETS60686.1 - 8.6 5.8 11.5 40 3.7 11.7 1.9 2 0 0 2 2 2 0 PPP4R2 TRAPPC10 PF12584.8 ETS60687.1 - 2e-22 79.5 0.5 3.7e-22 78.7 0.5 1.4 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 Mito_carr PF00153.27 ETS60688.1 - 7.3e-70 231.0 0.5 1.1e-23 82.9 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EOS1 PF12326.8 ETS60689.1 - 6.2e-63 211.9 0.0 6.2e-63 211.9 0.0 2.1 2 0 0 2 2 2 1 N-glycosylation protein SMYLE_N PF18615.1 ETS60689.1 - 6.7 6.2 11.5 10 5.6 1.2 2.3 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain MutS_V PF00488.21 ETS60690.1 - 5.5e-67 225.5 0.0 9.4e-67 224.7 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETS60690.1 - 1.4e-38 133.0 4.2 2.4e-38 132.3 4.2 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ETS60690.1 - 6.4e-20 71.5 0.0 1.4e-19 70.4 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ETS60690.1 - 6e-08 33.1 0.0 1.5e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 MutS domain II AAA_23 PF13476.6 ETS60690.1 - 0.004 17.7 0.0 0.02 15.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_27 PF13514.6 ETS60690.1 - 0.0049 16.5 0.0 0.022 14.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ETS60690.1 - 0.099 12.4 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain tRNA-synt_1b PF00579.25 ETS60691.1 - 5.5e-62 209.7 0.0 1.4e-61 208.4 0.0 1.7 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) DUF913 PF06025.12 ETS60691.1 - 0.15 11.0 3.7 0.28 10.1 3.7 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hexapep_2 PF14602.6 ETS60692.1 - 3e-11 42.9 6.1 5.7e-09 35.6 2.8 2.3 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 ETS60692.1 - 6.9e-11 41.4 6.3 1.1e-08 34.5 3.7 2.4 2 0 0 2 2 2 2 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 ETS60692.1 - 8.6e-09 35.5 0.1 1.6e-08 34.7 0.1 1.4 1 0 0 1 1 1 1 Maltose acetyltransferase Amino_oxidase PF01593.24 ETS60693.1 - 5.3e-52 177.6 0.6 6.6e-52 177.3 0.6 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS60693.1 - 2.5e-12 46.8 0.2 1e-11 44.9 0.2 2.1 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ETS60693.1 - 9.4e-10 37.7 0.6 3.4e-05 22.8 0.1 2.2 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 ETS60693.1 - 1.6e-08 34.1 0.1 2.9e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETS60693.1 - 1.6e-08 34.5 1.8 7.4e-07 29.1 0.0 2.6 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS60693.1 - 1.4e-07 31.0 0.2 1.4e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS60693.1 - 3.4e-07 30.7 0.7 8e-05 23.1 0.0 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ETS60693.1 - 6e-07 29.2 0.0 1.1e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETS60693.1 - 2.4e-06 27.0 0.2 4.2e-06 26.2 0.2 1.3 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 ETS60693.1 - 1.6e-05 24.3 1.1 0.00016 21.1 0.2 2.2 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 ETS60693.1 - 6e-05 22.3 2.1 0.001 18.2 0.1 2.6 2 1 1 3 3 3 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 ETS60693.1 - 0.00012 21.4 0.5 0.0072 15.6 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETS60693.1 - 0.00026 20.2 0.1 0.00026 20.2 0.1 1.5 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ETS60693.1 - 0.0053 16.7 0.2 0.069 13.1 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ETS60693.1 - 0.028 13.7 0.2 0.058 12.7 0.2 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Gti1_Pac2 PF09729.9 ETS60695.1 - 9.5e-60 201.8 0.0 9.5e-60 201.8 0.0 5.9 4 1 0 4 4 4 1 Gti1/Pac2 family HSA PF07529.13 ETS60695.1 - 2.1e-13 50.4 3.4 2.1e-13 50.4 3.4 5.2 6 0 0 6 6 6 1 HSA Myb_DNA-bind_6 PF13921.6 ETS60695.1 - 6.2e-06 26.4 0.3 6.2e-06 26.4 0.3 2.0 2 0 0 2 2 2 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 ETS60695.1 - 0.0022 18.2 0.3 0.0052 16.9 0.3 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 ETS60695.1 - 0.02 15.1 0.0 0.044 14.0 0.0 1.5 1 0 0 1 1 1 0 Myb-like DNA-binding domain Exo_endo_phos PF03372.23 ETS60697.1 - 2.2e-18 66.6 0.0 1.1e-17 64.3 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Sigma70_ner PF04546.13 ETS60697.1 - 1.1 9.1 12.6 0.035 14.0 5.1 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region NOA36 PF06524.12 ETS60697.1 - 2.1 7.6 7.6 3.7 6.8 7.6 1.3 1 0 0 1 1 1 0 NOA36 protein Syja_N PF02383.18 ETS60698.1 - 2.5e-78 263.6 0.0 3.5e-78 263.1 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain SF3A2 PF16835.5 ETS60699.1 - 4.2e-34 116.8 0.0 6.3e-34 116.2 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 ETS60699.1 - 1e-06 28.9 1.2 2.2e-06 27.9 0.7 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PRP4 PF08799.11 ETS60699.1 - 0.043 13.4 1.7 0.093 12.3 1.7 1.5 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like CactinC_cactus PF09732.9 ETS60699.1 - 0.087 12.8 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Cactus-binding C-terminus of cactin protein Proteasome PF00227.26 ETS60700.1 - 1.1e-28 100.1 0.0 1.3e-28 99.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Glycos_trans_3N PF02885.17 ETS60700.1 - 0.0044 16.9 0.0 0.54 10.2 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family, helical bundle domain Cu-oxidase_3 PF07732.15 ETS60701.1 - 4.6e-44 149.3 1.3 4.5e-43 146.1 0.1 2.9 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ETS60701.1 - 7.2e-31 106.7 12.7 5.7e-26 90.9 1.4 4.2 4 0 0 4 4 4 4 Multicopper oxidase Cu-oxidase PF00394.22 ETS60701.1 - 2.8e-27 95.8 0.0 8.1e-27 94.3 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase LAG1-DNAbind PF09271.11 ETS60702.1 - 1.2e-36 126.7 0.0 3.1e-36 125.3 0.0 1.8 1 0 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 ETS60702.1 - 6e-14 52.5 0.0 1.2e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 Beta-trefoil DNA-binding domain DUF3545 PF12065.8 ETS60702.1 - 0.15 12.1 0.2 0.32 11.0 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) Rad60-SLD PF11976.8 ETS60703.1 - 1.2e-25 89.2 0.6 1.3e-25 89.0 0.6 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETS60703.1 - 1.4e-15 56.7 0.1 1.6e-15 56.6 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Nuc_recep-AF1 PF11825.8 ETS60704.1 - 0.18 11.9 1.0 0.2 11.7 1.0 1.2 1 0 0 1 1 1 0 Nuclear/hormone receptor activator site AF-1 Pardaxin PF07425.11 ETS60704.1 - 0.35 10.5 11.3 2.4 7.8 4.3 3.1 1 1 1 2 2 2 0 Pardaxin Antimicrobial_8 PF08103.11 ETS60704.1 - 1.4 9.2 4.8 4.5 7.6 0.4 3.0 1 1 2 3 3 3 0 Uperin family TPR_1 PF00515.28 ETS60705.1 - 8.6e-37 123.5 19.3 4.8e-06 26.2 0.0 10.3 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETS60705.1 - 4e-33 110.9 21.4 0.00013 21.9 0.9 11.2 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETS60705.1 - 9.2e-26 87.9 17.2 0.00014 21.8 0.0 10.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETS60705.1 - 1.1e-17 64.4 24.0 1.4e-05 25.6 0.0 7.3 5 3 3 8 8 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETS60705.1 - 2e-17 62.6 12.7 0.00028 20.5 0.0 7.7 5 1 2 7 7 7 4 TPR repeat TPR_12 PF13424.6 ETS60705.1 - 3.2e-17 62.6 16.9 0.011 16.0 0.5 7.8 5 3 2 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETS60705.1 - 3.9e-16 58.2 7.1 0.012 15.9 0.1 9.6 9 1 0 9 9 9 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETS60705.1 - 1.1e-13 50.7 20.6 0.3 12.0 0.0 10.9 5 4 7 12 12 11 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETS60705.1 - 8.4e-11 41.1 10.3 0.039 14.0 0.1 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS60705.1 - 3.1e-09 36.9 2.7 0.00015 21.8 0.0 5.5 3 3 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS60705.1 - 1.1e-07 32.0 15.1 0.074 13.3 0.5 5.4 2 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETS60705.1 - 1.5e-07 31.8 28.9 0.00021 21.7 1.5 6.6 6 2 4 10 10 8 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETS60705.1 - 2e-05 24.3 13.3 1.3 9.0 0.1 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETS60705.1 - 6.7e-05 22.4 1.8 6.7e-05 22.4 1.8 4.0 4 1 0 4 4 4 1 MalT-like TPR region SpoIIIAH PF12685.7 ETS60705.1 - 0.00042 20.2 2.6 0.00042 20.2 2.6 2.0 2 0 0 2 2 2 1 SpoIIIAH-like protein Methyltrans_RNA PF04452.14 ETS60705.1 - 0.059 12.7 1.9 0.17 11.2 0.2 2.2 2 0 0 2 2 2 0 RNA methyltransferase SHNi-TPR PF10516.9 ETS60705.1 - 0.087 12.3 9.7 8 6.0 0.5 5.3 6 0 0 6 6 6 0 SHNi-TPR Coatomer_E PF04733.14 ETS60705.1 - 0.31 10.4 7.1 2.9 7.2 0.3 3.8 2 1 0 3 3 3 0 Coatomer epsilon subunit TPR_3 PF07720.12 ETS60705.1 - 0.63 10.1 7.4 1.1 9.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat PALP PF00291.25 ETS60706.1 - 1.2e-52 179.2 3.5 1.4e-50 172.4 3.5 2.1 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ABC_trans_N PF14510.6 ETS60706.1 - 0.0056 17.3 0.0 0.014 16.0 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal Abhydrolase_6 PF12697.7 ETS60706.1 - 0.18 12.4 2.5 0.58 10.7 1.0 2.2 1 1 1 2 2 2 0 Alpha/beta hydrolase family Complex1_LYR_2 PF13233.6 ETS60707.1 - 2.5e-16 60.2 0.2 4.2e-16 59.5 0.2 1.4 1 0 0 1 1 1 1 Complex1_LYR-like DUF4611 PF15387.6 ETS60708.1 - 0.009 16.2 1.8 0.009 16.2 1.8 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 ETS60708.1 - 0.033 14.6 2.4 0.065 13.6 2.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Gluconate_2-dh3 PF13618.6 ETS60708.1 - 0.042 14.1 0.7 0.079 13.2 0.0 1.9 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 NOA36 PF06524.12 ETS60708.1 - 3.5 6.9 6.0 5 6.4 6.0 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2347 PF09804.9 ETS60709.1 - 1.7e-39 136.2 0.0 6e-38 131.1 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) Afi1 PF07792.12 ETS60709.1 - 0.13 12.7 0.1 0.13 12.7 0.1 3.0 3 1 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 ETS60709.1 - 0.25 10.0 0.0 0.75 8.4 0.0 1.8 1 1 0 1 1 1 0 Transport protein Avl9 Mito_carr PF00153.27 ETS60710.1 - 7.6e-63 208.5 5.1 3.9e-22 78.0 0.3 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein COX16 PF14138.6 ETS60711.1 - 6.1e-29 100.4 0.1 1.2e-28 99.4 0.1 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Evr1_Alr PF04777.13 ETS60711.1 - 1.3e-27 96.2 0.1 4.9e-27 94.3 0.0 2.0 2 0 0 2 2 2 1 Erv1 / Alr family CcmH PF03918.14 ETS60711.1 - 0.18 11.1 0.0 0.37 10.1 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein PLA2_B PF01735.18 ETS60712.1 - 2.2e-16 59.3 0.1 3.2e-12 45.6 0.1 3.0 3 0 0 3 3 3 2 Lysophospholipase catalytic domain ACPS PF01648.20 ETS60712.1 - 8.8e-14 51.6 0.1 3.4e-13 49.7 0.1 2.1 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily SCAB-PH PF17684.1 ETS60712.1 - 0.17 12.1 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 PH domain of plant-specific actin-binding protein Longin PF13774.6 ETS60714.1 - 5.5e-24 84.0 0.0 1e-23 83.2 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain DEAD PF00270.29 ETS60714.1 - 2.8e-13 50.0 0.0 5.4e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Synaptobrevin PF00957.21 ETS60714.1 - 1.9e-10 40.4 0.2 4.7e-10 39.1 0.2 1.7 1 0 0 1 1 1 1 Synaptobrevin Helicase_C PF00271.31 ETS60714.1 - 4.5e-05 23.8 0.0 0.00012 22.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain BTB_2 PF02214.22 ETS60715.1 - 0.00037 20.8 0.0 0.034 14.5 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain Ribosomal_S10 PF00338.22 ETS60716.1 - 1.5e-24 86.1 0.0 3.1e-24 85.1 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF1708 PF08101.11 ETS60720.1 - 1.5e-22 80.4 0.2 3e-16 59.6 0.8 2.8 1 1 0 2 2 2 2 Domain of unknown function (DUF1708) RhoGAP PF00620.27 ETS60720.1 - 1.5e-06 28.1 0.0 2.4e-05 24.2 0.0 2.6 2 1 0 2 2 2 1 RhoGAP domain FA_hydroxylase PF04116.13 ETS60721.1 - 3.1e-24 85.8 17.7 3.1e-24 85.8 17.7 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Bromodomain PF00439.25 ETS60722.1 - 9e-22 77.0 0.1 1.8e-21 76.0 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Hydrolase_2 PF07486.12 ETS60722.1 - 0.18 12.7 0.1 0.59 11.0 0.1 1.9 1 0 0 1 1 1 0 Cell Wall Hydrolase SDA1 PF05285.12 ETS60722.1 - 0.21 11.0 33.3 0.12 11.8 17.3 2.9 3 1 0 3 3 3 0 SDA1 Nop14 PF04147.12 ETS60722.1 - 0.69 8.1 28.9 0.85 7.8 20.1 2.5 2 0 0 2 2 2 0 Nop14-like family CDC45 PF02724.14 ETS60722.1 - 3.8 5.7 21.7 1.6 7.0 11.8 2.6 3 0 0 3 3 3 0 CDC45-like protein WD40 PF00400.32 ETS60723.1 - 6.2e-44 147.1 12.1 5.8e-08 33.3 0.3 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60723.1 - 0.00016 21.9 0.3 0.88 9.9 0.1 4.4 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS60723.1 - 0.0014 17.4 0.3 2.4 6.7 0.0 3.2 2 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETS60723.1 - 0.019 14.3 0.0 0.042 13.2 0.0 1.6 1 0 0 1 1 1 0 WD40-like domain CbiG_N PF11760.8 ETS60723.1 - 0.12 12.4 0.0 9.3 6.3 0.0 2.6 1 1 0 2 2 2 0 Cobalamin synthesis G N-terminal TFIIS_M PF07500.14 ETS60724.1 - 1.2e-30 106.3 1.7 1.2e-30 106.3 1.7 2.5 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 ETS60724.1 - 8.3e-19 67.2 8.9 1.3e-18 66.5 8.9 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 ETS60724.1 - 4.4e-11 42.6 0.2 1.4e-10 41.0 0.2 1.9 1 0 0 1 1 1 1 TFIIS helical bundle-like domain HTH_22 PF13309.6 ETS60724.1 - 0.062 13.4 0.3 0.15 12.2 0.3 1.6 1 0 0 1 1 1 0 HTH domain zinc_ribbon_4 PF13717.6 ETS60724.1 - 0.28 11.2 3.9 0.59 10.1 0.4 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DUF3275 PF11679.8 ETS60724.1 - 1 9.3 6.1 2.1 8.3 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3275) zf-DNL PF05180.12 ETS60724.1 - 1.1 9.2 4.7 1.1 9.2 2.5 2.1 2 0 0 2 2 2 0 DNL zinc finger Ammonium_transp PF00909.21 ETS60725.1 - 1.6e-112 376.2 29.9 1.8e-112 376.0 29.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family MRP-S28 PF10213.9 ETS60726.1 - 4.1e-39 133.9 0.1 6.5e-39 133.3 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein AAA_33 PF13671.6 ETS60727.1 - 1.4e-11 44.7 0.4 4.7e-05 23.6 0.2 2.3 1 1 1 2 2 2 2 AAA domain tRNA_lig_kinase PF08303.11 ETS60727.1 - 5.2e-07 29.9 0.0 7.2e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_22 PF13401.6 ETS60727.1 - 0.00017 21.9 0.0 0.00075 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETS60727.1 - 0.0006 20.4 0.1 0.0026 18.3 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETS60727.1 - 0.01 16.2 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain dNK PF01712.19 ETS60727.1 - 0.01 15.7 0.0 0.039 13.8 0.0 1.8 2 0 0 2 2 2 0 Deoxynucleoside kinase TsaE PF02367.17 ETS60727.1 - 0.022 14.8 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 ETS60727.1 - 0.051 12.6 0.0 0.093 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 ETS60727.1 - 0.085 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 ETS60727.1 - 0.1 12.0 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_29 PF13555.6 ETS60727.1 - 0.17 11.7 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 ETS60727.1 - 0.23 11.2 0.0 0.36 10.6 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein SIR2 PF02146.17 ETS60728.1 - 2e-53 181.0 0.0 2.8e-53 180.5 0.0 1.2 1 0 0 1 1 1 1 Sir2 family adh_short PF00106.25 ETS60729.1 - 5.4e-48 163.1 0.2 6.6e-48 162.8 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60729.1 - 1.2e-31 110.1 0.2 1.6e-31 109.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS60729.1 - 2.5e-10 40.5 0.1 3.6e-10 40.0 0.1 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ETS60729.1 - 0.00016 21.2 0.0 0.00039 19.9 0.0 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 ETS60729.1 - 0.00023 21.1 0.0 0.00041 20.3 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETS60729.1 - 0.011 15.2 0.0 0.03 13.8 0.0 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Lactamase_B_2 PF12706.7 ETS60730.1 - 8.3e-31 107.1 0.0 1.5e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ETS60730.1 - 5e-06 26.5 0.0 0.0005 20.0 0.0 3.0 2 1 0 2 2 2 1 Beta-lactamase superfamily domain DUF2099 PF09872.9 ETS60730.1 - 0.14 11.3 0.1 0.21 10.7 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2099) A_deamin PF02137.18 ETS60731.1 - 3.1e-41 141.9 0.0 8.1e-41 140.5 0.0 1.6 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain F-box-like PF12937.7 ETS60732.1 - 0.008 16.0 0.0 0.068 13.1 0.0 2.5 2 1 0 2 2 2 1 F-box-like Peptidase_M20 PF01546.28 ETS60733.1 - 1.2e-33 116.6 0.1 1.9e-33 115.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETS60733.1 - 4.1e-12 46.0 0.5 1.3e-11 44.4 0.5 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 ETS60733.1 - 0.0086 15.8 0.0 0.021 14.5 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M28 Herpes_BLRF2 PF05812.12 ETS60733.1 - 0.21 11.7 1.0 1.5 9.0 0.9 2.1 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein DER1 PF04511.15 ETS60734.1 - 4e-37 128.0 0.2 5.1e-37 127.7 0.2 1.1 1 0 0 1 1 1 1 Der1-like family zf-CCHC PF00098.23 ETS60735.1 - 2e-13 49.7 19.4 6.6e-05 22.8 1.2 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 ETS60735.1 - 2.3e-06 27.3 19.1 0.026 14.3 1.6 4.3 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 ETS60735.1 - 0.018 14.8 19.1 0.12 12.2 0.4 4.3 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_6 PF15288.6 ETS60735.1 - 0.021 14.6 0.6 0.021 14.6 0.6 3.7 4 0 0 4 4 4 0 Zinc knuckle SOBP PF15279.6 ETS60735.1 - 0.46 11.1 7.4 1.1 9.8 7.4 1.6 1 0 0 1 1 1 0 Sine oculis-binding protein ORC6 PF05460.13 ETS60735.1 - 3.6 6.8 16.0 7.3 5.8 16.0 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PHD_4 PF16866.5 ETS60735.1 - 4.4 7.5 9.0 5.5 7.1 1.6 3.1 2 1 1 3 3 3 0 PHD-finger zf-CCHC_3 PF13917.6 ETS60735.1 - 7.2 6.7 13.9 13 5.9 0.4 4.1 2 1 2 4 4 4 0 Zinc knuckle Sar8_2 PF03058.14 ETS60735.1 - 10 6.8 6.5 29 5.3 0.2 2.7 1 1 1 2 2 2 0 Sar8.2 family Methyltransf_25 PF13649.6 ETS60736.1 - 3.3e-11 43.7 0.0 6e-11 42.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS60736.1 - 4.6e-10 39.5 0.0 6.6e-10 39.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ETS60736.1 - 1e-09 38.2 0.0 1.4e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ETS60736.1 - 6.7e-08 33.1 0.0 1.3e-07 32.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS60736.1 - 1.3e-07 31.6 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS60736.1 - 6.6e-06 26.8 0.0 1.4e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ETS60736.1 - 4.5e-05 22.5 0.0 6.2e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CMAS PF02353.20 ETS60736.1 - 0.00054 19.3 0.0 0.00073 18.9 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ETS60736.1 - 0.0013 18.3 0.3 0.003 17.1 0.3 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ETS60736.1 - 0.032 14.2 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 ETS60736.1 - 0.12 13.4 0.0 0.29 12.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ETS60736.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ETS60736.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 ETS60736.1 - 0.16 11.7 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase DOT1 PF08123.13 ETS60736.1 - 0.16 11.5 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 V-SNARE_C PF12352.8 ETS60737.1 - 1.3e-15 57.4 0.5 3.3e-15 56.1 0.5 1.8 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETS60737.1 - 4.2e-06 26.6 0.0 1.3e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 Sec20 Mito_fiss_reg PF05308.11 ETS60737.1 - 0.046 13.8 1.0 0.056 13.5 1.0 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF3958 PF13125.6 ETS60737.1 - 0.066 13.4 0.2 3.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) Spc7 PF08317.11 ETS60737.1 - 0.085 11.7 0.6 0.2 10.5 0.2 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein FliD_N PF02465.18 ETS60737.1 - 1.6 9.5 5.4 2.8 8.7 3.2 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Oxidored_q6 PF01058.22 ETS60738.1 - 5e-21 74.9 0.1 7.6e-21 74.3 0.1 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit WD40 PF00400.32 ETS60740.1 - 1.5e-09 38.3 15.1 0.011 16.5 0.2 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60740.1 - 2.6e-07 30.9 0.0 0.0033 17.7 0.0 4.0 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 ETS60740.1 - 0.025 13.3 0.6 0.89 8.2 0.5 2.5 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DAP3 PF10236.9 ETS60741.1 - 4.4e-72 242.9 0.9 5.5e-72 242.6 0.9 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 ETS60741.1 - 3.5e-08 34.0 2.6 4.4e-08 33.7 0.3 2.2 2 0 0 2 2 2 1 AAA ATPase domain ATPase_2 PF01637.18 ETS60741.1 - 0.00064 19.7 0.1 0.0085 16.0 0.0 2.4 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ETS60741.1 - 0.00089 19.6 1.1 0.0069 16.7 0.2 2.7 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ETS60741.1 - 0.024 14.6 0.0 0.26 11.3 0.0 2.6 3 0 0 3 3 3 0 AAA domain Helicase_RecD PF05127.14 ETS60741.1 - 0.034 14.0 0.1 0.034 14.0 0.1 2.8 3 1 0 3 3 3 0 Helicase SHE3 PF17078.5 ETS60742.1 - 1.2e-06 28.4 11.6 5.2e-05 23.1 0.6 4.0 2 1 2 4 4 4 3 SWI5-dependent HO expression protein 3 PspA_IM30 PF04012.12 ETS60742.1 - 0.0063 16.1 7.7 0.0063 16.1 7.7 4.3 3 1 1 4 4 4 1 PspA/IM30 family Prominin PF05478.11 ETS60742.1 - 0.16 9.9 1.2 0.36 8.7 1.2 1.5 1 0 0 1 1 1 0 Prominin Bap31_Bap29_C PF18035.1 ETS60742.1 - 0.42 10.6 8.9 2.6 8.1 1.0 3.1 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Myosin_tail_1 PF01576.19 ETS60742.1 - 0.9 7.3 27.3 0.047 11.5 9.3 3.2 2 1 1 3 3 3 0 Myosin tail TolA_bind_tri PF16331.5 ETS60742.1 - 2.9 8.0 18.0 0.049 13.7 1.1 4.3 4 0 0 4 4 4 0 TolA binding protein trimerisation GAS PF13851.6 ETS60742.1 - 3.2 7.0 16.4 2.9 7.2 6.2 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Spectrin PF00435.21 ETS60742.1 - 8.4 6.9 17.1 0.45 11.0 1.4 3.8 3 0 0 3 3 3 0 Spectrin repeat PX PF00787.24 ETS60743.1 - 4.4e-26 91.1 0.1 6.4e-26 90.6 0.1 1.2 1 0 0 1 1 1 1 PX domain APC_u14 PF16635.5 ETS60743.1 - 0.26 11.8 2.3 0.62 10.6 2.3 1.7 1 0 0 1 1 1 0 Unstructured region on APC between SAMP and APC_crr LCD1 PF09798.9 ETS60744.1 - 0.00051 18.7 4.3 0.37 9.3 0.0 2.2 2 0 0 2 2 2 2 DNA damage checkpoint protein TMF_DNA_bd PF12329.8 ETS60744.1 - 0.0013 18.7 4.5 0.0013 18.7 4.5 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding DUF641 PF04859.12 ETS60744.1 - 0.006 16.9 1.8 0.006 16.9 1.8 1.9 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) Atg14 PF10186.9 ETS60744.1 - 0.048 12.8 9.9 0.079 12.0 9.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Tugs PF17840.1 ETS60744.1 - 0.12 12.6 1.6 0.49 10.6 1.6 2.1 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Spc7 PF08317.11 ETS60744.1 - 0.19 10.6 9.5 0.4 9.5 9.5 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein HOOK PF05622.12 ETS60744.1 - 0.41 8.7 13.6 0.66 8.1 13.6 1.2 1 0 0 1 1 1 0 HOOK protein Fib_alpha PF08702.10 ETS60744.1 - 8.2 6.6 7.2 19 5.5 7.2 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family XPG_N PF00752.17 ETS60745.1 - 4.9e-35 120.0 0.0 1.1e-34 119.0 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ETS60745.1 - 4.7e-30 103.8 1.2 9.3e-30 102.8 0.0 2.1 3 0 0 3 3 3 1 XPG I-region 5_3_exonuc PF01367.20 ETS60745.1 - 4.4e-08 33.6 0.0 1.6e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ETS60745.1 - 0.0036 17.9 0.0 0.012 16.2 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 ETS60745.1 - 0.076 12.9 0.0 0.4 10.6 0.0 2.3 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda PNGaseA PF12222.8 ETS60746.1 - 3.4e-98 329.4 0.0 5e-98 328.8 0.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A DUF1684 PF07920.11 ETS60746.1 - 0.095 13.0 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1684) COQ7 PF03232.13 ETS60747.1 - 5.3e-66 221.6 0.3 1.7e-65 220.0 0.4 1.8 2 0 0 2 2 2 1 Ubiquinone biosynthesis protein COQ7 FAD_binding_3 PF01494.19 ETS60747.1 - 2.2e-14 53.5 5.5 9.9e-09 34.9 0.2 3.3 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 ETS60747.1 - 1.9e-05 24.4 1.0 4.7e-05 23.1 1.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase SE PF08491.10 ETS60747.1 - 0.0015 17.6 0.0 0.0025 16.9 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase Ferritin PF00210.24 ETS60747.1 - 0.0049 16.8 0.6 0.068 13.1 0.0 2.5 2 0 0 2 2 2 1 Ferritin-like domain NAD_binding_9 PF13454.6 ETS60747.1 - 0.0085 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ETS60747.1 - 0.029 13.6 0.0 0.052 12.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS60747.1 - 0.098 13.2 0.1 0.21 12.2 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Ferritin_2 PF13668.6 ETS60747.1 - 0.29 11.3 1.4 4.3 7.5 0.0 3.1 2 1 0 3 3 3 0 Ferritin-like domain Cyclin PF08613.11 ETS60748.1 - 4.8e-08 33.5 0.5 2.4e-07 31.3 0.0 2.4 2 0 0 2 2 2 1 Cyclin Pkinase PF00069.25 ETS60749.1 - 5.9e-29 101.2 0.0 2.6e-28 99.1 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60749.1 - 2.9e-14 53.0 0.0 6.1e-14 51.9 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS60749.1 - 0.13 11.0 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase FAD_binding_7 PF03441.14 ETS60750.1 - 3.7e-53 180.0 3.0 5.2e-53 179.5 3.0 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 ETS60750.1 - 2.9e-21 76.2 0.0 7.4e-21 74.8 0.0 1.6 1 1 0 1 1 1 1 DNA photolyase HSP70 PF00012.20 ETS60751.1 - 6.1e-162 539.9 0.8 9e-162 539.3 0.8 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETS60751.1 - 5.9e-12 45.0 0.0 1.5e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein Aldedh PF00171.22 ETS60752.1 - 2.9e-14 52.5 5.9 5.3e-12 45.0 4.3 2.9 2 1 0 2 2 2 2 Aldehyde dehydrogenase family Ribosomal_L34 PF00468.17 ETS60753.1 - 1e-16 60.6 9.6 1.7e-16 59.9 9.6 1.4 1 0 0 1 1 1 1 Ribosomal protein L34 ATP-synt_C PF00137.21 ETS60754.1 - 1e-27 96.2 34.0 9.3e-16 57.9 13.8 3.0 3 0 0 3 3 3 2 ATP synthase subunit C Insulin_TMD PF17870.1 ETS60754.1 - 7.9 6.6 6.8 1.7 8.8 0.7 2.4 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment Dus PF01207.17 ETS60755.1 - 9.9e-47 159.5 0.0 4.1e-32 111.5 0.0 2.3 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 ETS60755.1 - 0.018 14.9 8.4 0.034 14.0 1.0 2.7 2 1 0 2 2 2 0 CCCH-type zinc finger DUF3487 PF11990.8 ETS60755.1 - 0.19 11.6 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Torus PF16131.5 ETS60755.1 - 0.45 11.2 2.9 3.6 8.3 0.2 2.6 2 0 0 2 2 2 0 Torus domain zf_CCCH_4 PF18345.1 ETS60755.1 - 1.9 8.7 4.1 2.8 8.1 0.6 2.5 2 0 0 2 2 2 0 Zinc finger domain DUF155 PF02582.14 ETS60756.1 - 5e-50 170.0 0.7 9.1e-50 169.2 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 RRN3 PF05327.11 ETS60756.1 - 4.9 5.6 6.0 53 2.2 6.6 2.1 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 MPLKIP PF15502.6 ETS60757.1 - 0.018 15.3 0.4 0.053 13.7 0.4 2.0 1 1 0 1 1 1 0 M-phase-specific PLK1-interacting protein SQHop_cyclase_N PF13249.6 ETS60758.1 - 2.3e-55 187.8 0.6 2.5e-44 151.5 0.1 4.0 4 0 0 4 4 4 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 ETS60758.1 - 2.5e-44 151.7 5.5 1.1e-40 139.7 0.9 3.3 2 2 1 3 3 3 3 Squalene-hopene cyclase C-terminal domain Prenyltrans PF00432.21 ETS60758.1 - 2.5e-34 116.7 5.7 1.1e-09 37.8 0.2 6.7 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 ETS60758.1 - 0.00062 18.9 0.9 0.006 15.6 0.7 2.6 3 1 0 3 3 3 1 A-macroglobulin TED domain Pec_lyase PF09492.10 ETS60758.1 - 0.00094 18.6 0.9 0.62 9.3 0.0 3.9 3 1 2 5 5 5 1 Pectic acid lyase DUF1925 PF09094.11 ETS60758.1 - 0.052 13.9 0.1 21 5.5 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1925) DUF1242 PF06842.12 ETS60759.1 - 2.5e-18 65.6 0.7 3.3e-18 65.2 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) GST_N PF02798.20 ETS60760.1 - 1e-10 41.8 0.2 2.6e-10 40.5 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ETS60760.1 - 1e-10 41.7 0.0 3.5e-10 40.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ETS60760.1 - 6.5e-10 39.3 0.0 1.8e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETS60760.1 - 9.3e-09 35.2 0.2 2.4e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS60760.1 - 4.5e-07 30.0 0.0 1.4e-06 28.4 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ETS60760.1 - 4.9e-07 30.0 0.0 1.1e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 ETS60760.1 - 0.023 14.5 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_C_6 PF17171.4 ETS60760.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sua5_yciO_yrdC PF01300.18 ETS60761.1 - 1.1e-47 161.9 0.1 7.5e-47 159.1 0.0 2.1 2 0 0 2 2 2 1 Telomere recombination SUA5 PF03481.13 ETS60761.1 - 4e-33 114.8 0.0 7.8e-33 113.9 0.0 1.5 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding Pkinase PF00069.25 ETS60762.1 - 1e-70 238.2 0.0 1.4e-70 237.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60762.1 - 1.6e-56 191.5 0.0 2.5e-56 190.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CH PF00307.31 ETS60762.1 - 1.8e-10 41.0 0.0 3.7e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Calponin homology (CH) domain C1_1 PF00130.22 ETS60762.1 - 1.8e-07 30.9 6.9 2.9e-07 30.2 6.9 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CDC24 PF06395.11 ETS60762.1 - 6.3e-05 23.2 0.0 0.00013 22.1 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin Kinase-like PF14531.6 ETS60762.1 - 0.0042 16.4 0.0 0.013 14.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ETS60762.1 - 0.0054 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ETS60762.1 - 0.0097 14.7 0.5 0.031 13.1 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ETS60762.1 - 0.011 14.8 0.2 0.018 14.1 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 C1_2 PF03107.16 ETS60762.1 - 0.047 14.0 2.2 0.091 13.1 2.2 1.4 1 0 0 1 1 1 0 C1 domain Zn_ribbon_17 PF17120.5 ETS60762.1 - 0.062 12.9 7.8 0.11 12.1 7.8 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type CAMSAP_CH PF11971.8 ETS60762.1 - 0.09 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 CAMSAP CH domain CxC3 PF18804.1 ETS60762.1 - 0.26 11.2 2.1 5.1 7.0 1.3 2.4 2 0 0 2 2 2 0 CxC3 like cysteine cluster associated with KDZ transposases PHD PF00628.29 ETS60762.1 - 0.34 10.8 7.9 0.65 9.9 7.9 1.4 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 ETS60762.1 - 0.7 9.9 8.7 1.3 9.0 8.7 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_3 PF13922.6 ETS60762.1 - 1.1 9.7 4.4 3.6 8.1 3.3 2.6 2 0 0 2 2 1 0 PHD domain of transcriptional enhancer, Asx DUF2530 PF10745.9 ETS60763.1 - 2 8.7 4.1 6.2 7.1 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) WD40 PF00400.32 ETS60765.1 - 7.7e-21 74.0 22.3 0.00055 20.7 0.4 7.0 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60765.1 - 1.3e-08 35.0 3.7 0.023 15.0 0.2 4.3 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS60765.1 - 0.00021 20.3 0.3 2.1 7.3 0.0 3.7 3 2 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ETS60765.1 - 0.94 10.1 4.3 9.3 6.9 0.7 3.9 3 2 1 4 4 4 0 PQQ-like domain EamA PF00892.20 ETS60766.1 - 1.3e-26 93.4 32.7 4e-14 53.0 9.7 2.2 2 0 0 2 2 2 2 EamA-like transporter family DUF2070 PF09843.9 ETS60766.1 - 0.84 7.9 19.0 0.033 12.5 6.2 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Fungal_trans PF04082.18 ETS60767.1 - 8.2e-13 48.0 0.6 1.3e-12 47.4 0.1 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS60767.1 - 2.2e-06 27.7 9.7 4.5e-06 26.7 9.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Metallothio_Euk PF12749.7 ETS60767.1 - 0.058 13.6 2.8 0.12 12.5 2.8 1.5 1 0 0 1 1 1 0 Eukaryotic metallothionein Hydrolase_6 PF13344.6 ETS60768.1 - 1.1e-09 38.3 0.0 2e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS60768.1 - 2.7e-06 27.4 0.0 8.3e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 HAD-hyrolase-like Hexapep PF00132.24 ETS60769.1 - 2e-09 36.8 14.6 0.00015 21.4 3.4 5.0 3 2 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ETS60769.1 - 1.7e-06 27.6 7.6 0.0094 15.7 2.7 3.6 3 0 0 3 3 3 3 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ETS60769.1 - 0.013 14.4 0.4 0.027 13.4 0.2 1.4 1 1 0 1 1 1 0 L-fucokinase Sec1 PF00995.23 ETS60770.1 - 1e-132 444.3 0.0 1.2e-132 444.2 0.0 1.0 1 0 0 1 1 1 1 Sec1 family SRX PF09201.10 ETS60770.1 - 0.14 12.0 0.0 26 4.6 0.0 2.4 2 0 0 2 2 2 0 SRX, signal recognition particle receptor alpha subunit NTP_transf_3 PF12804.7 ETS60771.1 - 7e-05 23.2 0.1 0.00019 21.8 0.1 1.8 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ETS60771.1 - 9.5e-05 22.0 4.0 0.0035 17.0 4.0 3.1 1 1 1 2 2 2 1 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ETS60771.1 - 0.0084 15.8 4.7 0.34 10.7 4.7 2.5 1 1 0 1 1 1 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 ETS60771.1 - 0.009 14.2 0.4 0.014 13.6 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transferase PF00483.23 ETS60771.1 - 0.038 13.6 0.0 0.17 11.5 0.1 1.9 2 0 0 2 2 2 0 Nucleotidyl transferase CTP_transf_3 PF02348.19 ETS60771.1 - 0.071 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Cytidylyltransferase Aa_trans PF01490.18 ETS60772.1 - 3.9e-73 246.5 17.0 3.9e-73 246.5 17.0 1.6 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ETS60772.1 - 0.00046 19.4 10.6 0.00046 19.4 10.6 1.6 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family Med3 PF11593.8 ETS60772.1 - 3.9 6.6 5.5 5.6 6.1 5.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal MAGI_u5 PF16666.5 ETS60772.1 - 6.8 6.8 6.2 13 6.0 6.2 1.3 1 0 0 1 1 1 0 Unstructured region on MAGI SR-25 PF10500.9 ETS60773.1 - 0.57 9.7 3.7 0.98 9.0 3.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PACT_coil_coil PF10495.9 ETS60774.1 - 1e-10 42.0 0.9 1e-10 42.0 0.9 6.2 7 0 0 7 7 7 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein DUF4140 PF13600.6 ETS60774.1 - 0.00011 22.5 5.4 0.00011 22.5 5.4 12.5 2 2 6 8 8 8 1 N-terminal domain of unknown function (DUF4140) Cep57_CLD_2 PF14197.6 ETS60774.1 - 0.0059 16.7 3.3 0.0059 16.7 3.3 11.0 7 3 2 9 9 9 2 Centrosome localisation domain of PPC89 CENP-F_leu_zip PF10473.9 ETS60774.1 - 0.0079 16.2 19.5 0.0079 16.2 19.5 8.3 2 2 3 7 7 7 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vac_Fusion PF02346.16 ETS60774.1 - 0.93 9.2 4.0 1.2 8.8 0.2 3.2 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Spc7 PF08317.11 ETS60774.1 - 1.8 7.3 111.9 1 8.2 11.7 6.6 2 2 5 7 7 7 0 Spc7 kinetochore protein FapA PF03961.13 ETS60774.1 - 7.8 5.0 59.0 0.21 10.1 2.2 6.4 3 2 1 6 6 6 0 Flagellar Assembly Protein A FliD_C PF07195.12 ETS60774.1 - 9.8 5.5 15.0 63 2.9 0.0 4.7 3 3 1 4 4 4 0 Flagellar hook-associated protein 2 C-terminus Zn_clus PF00172.18 ETS60775.1 - 1.9e-06 27.9 10.2 1.9e-06 27.9 10.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 ETS60775.1 - 0.0013 19.1 0.0 0.0013 19.1 0.0 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF1610 PF07754.11 ETS60775.1 - 0.11 12.5 2.5 0.23 11.4 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) ABC_membrane PF00664.23 ETS60776.1 - 1.9e-44 152.4 1.4 2.9e-44 151.8 1.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ETS60776.1 - 4.2e-32 111.5 0.0 9e-32 110.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_ATPase PF09818.9 ETS60776.1 - 0.0023 16.8 0.0 0.0036 16.2 0.0 1.2 1 0 0 1 1 1 1 Predicted ATPase of the ABC class SMC_N PF02463.19 ETS60776.1 - 0.0035 16.8 0.0 0.059 12.8 0.0 1.9 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ETS60776.1 - 0.15 11.3 0.0 0.33 10.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin CLASP_N PF12348.8 ETS60777.1 - 5.8e-23 81.6 0.0 8.6e-23 81.1 0.0 1.3 1 0 0 1 1 1 1 CLASP N terminal CBF PF03914.17 ETS60778.1 - 1.2e-51 175.1 3.3 4.7e-51 173.2 0.0 3.3 4 0 0 4 4 4 1 CBF/Mak21 family Adaptin_N PF01602.20 ETS60778.1 - 0.0067 15.0 0.2 0.61 8.6 0.0 2.8 3 1 0 3 3 3 2 Adaptin N terminal region Peptidase_C15 PF01470.17 ETS60779.1 - 3.7e-09 37.0 0.0 0.0011 19.2 0.0 2.6 3 1 0 3 3 3 2 Pyroglutamyl peptidase Pkinase PF00069.25 ETS60781.1 - 5.5e-65 219.4 0.0 7.2e-65 219.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60781.1 - 1.3e-44 152.5 0.0 2e-44 151.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS60781.1 - 1.3e-09 37.4 0.0 1.3e-08 34.1 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ETS60781.1 - 1.6e-06 27.7 0.0 3.2e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETS60781.1 - 0.069 13.1 1.0 9.1 6.1 0.0 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family RIO1 PF01163.22 ETS60781.1 - 0.076 12.6 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 ETS60781.1 - 0.11 11.4 0.0 1 8.2 0.0 2.3 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ETS60781.1 - 0.12 11.7 0.0 0.26 10.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UCH PF00443.29 ETS60783.1 - 3.4e-40 138.2 0.0 7.7e-40 137.0 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS60783.1 - 1.3e-06 28.3 0.0 2.1e-05 24.3 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Pantoate_ligase PF02569.15 ETS60783.1 - 0.025 13.8 0.4 0.046 12.9 0.4 1.3 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Edc3_linker PF16598.5 ETS60783.1 - 1.3 9.7 4.1 5.7 7.7 1.0 2.5 2 0 0 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 DnaJ-X PF14308.6 ETS60784.1 - 1e-48 165.6 3.1 1e-48 165.6 3.1 1.8 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 ETS60784.1 - 6.7e-25 87.0 2.9 9.5e-25 86.5 1.7 2.0 2 0 0 2 2 2 1 DnaJ domain OmdA PF13376.6 ETS60784.1 - 0.11 12.5 3.0 0.54 10.3 3.0 2.3 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated Las1 PF04031.13 ETS60785.1 - 1.7e-45 154.9 5.3 4.4e-45 153.5 1.9 2.3 2 0 0 2 2 2 1 Las1-like HTH_1 PF00126.27 ETS60785.1 - 0.12 12.3 1.3 0.52 10.3 1.3 2.1 1 1 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Pet127 PF08634.10 ETS60790.1 - 1.1e-104 349.7 0.3 1.6e-104 349.2 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Tmemb_cc2 PF10267.9 ETS60790.1 - 1.9 7.5 9.5 3.5 6.7 9.5 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Ribosomal_L6e PF01159.19 ETS60791.1 - 1.5e-38 131.7 0.9 1.5e-38 131.7 0.9 1.7 2 0 0 2 2 2 1 Ribosomal protein L6e Phosphoesterase PF04185.14 ETS60791.1 - 0.068 12.4 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 Phosphoesterase family Ribosomal_L6e_N PF03868.15 ETS60791.1 - 0.094 13.0 0.8 0.094 13.0 0.8 2.8 3 0 0 3 3 3 0 Ribosomal protein L6, N-terminal domain Thi4 PF01946.17 ETS60793.1 - 4.6e-102 340.2 0.4 5.6e-102 340.0 0.4 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 ETS60793.1 - 1.9e-07 31.0 2.3 4.8e-07 29.7 1.3 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS60793.1 - 5.5e-07 29.7 0.2 1.5e-06 28.3 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ETS60793.1 - 1.4e-06 27.6 0.4 1.5e-05 24.2 0.5 2.1 1 1 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 ETS60793.1 - 1.4e-05 24.5 0.1 2.2e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS60793.1 - 1.7e-05 24.1 1.4 0.00026 20.2 0.5 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 ETS60793.1 - 2.4e-05 24.4 0.1 0.0016 18.4 0.1 2.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ETS60793.1 - 0.0005 18.9 0.2 0.00075 18.3 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein Trp_halogenase PF04820.14 ETS60793.1 - 0.012 14.5 0.2 0.018 13.9 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 ETS60793.1 - 0.037 13.3 0.1 0.063 12.5 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETS60793.1 - 0.061 12.4 0.0 0.21 10.6 0.0 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 ETS60793.1 - 0.069 12.5 0.4 0.086 12.2 0.4 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ETS60793.1 - 0.17 11.1 0.0 0.38 10.0 0.0 1.5 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Xpo1 PF08389.12 ETS60794.1 - 1.1e-19 71.0 1.6 2.6e-16 60.0 0.0 4.7 6 0 0 6 6 6 1 Exportin 1-like protein Importin_rep_4 PF18808.1 ETS60794.1 - 0.051 13.9 0.9 0.15 12.4 0.1 2.2 2 0 0 2 2 2 0 Importin repeat HEAT PF02985.22 ETS60794.1 - 0.053 13.8 3.4 1 9.8 0.0 4.4 5 0 0 5 5 5 0 HEAT repeat Bac_DnaA PF00308.18 ETS60794.1 - 0.053 13.4 0.2 8.2 6.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein HEAT_EZ PF13513.6 ETS60794.1 - 4.2 8.0 6.8 4.5 7.9 0.1 3.9 4 0 0 4 4 4 0 HEAT-like repeat HSF_DNA-bind PF00447.17 ETS60796.1 - 2e-20 73.2 0.0 3.8e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding PRP1_N PF06424.12 ETS60797.1 - 1.3e-45 155.4 5.0 1.3e-45 155.4 5.0 2.1 2 0 0 2 2 2 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 ETS60797.1 - 1.2e-20 72.4 45.6 0.054 14.3 0.0 13.7 8 6 6 14 14 13 7 Tetratricopeptide repeat TPR_19 PF14559.6 ETS60797.1 - 4.7e-13 49.5 21.9 0.47 11.0 0.1 10.3 7 3 3 11 11 11 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETS60797.1 - 0.00023 21.0 0.2 11 6.5 0.1 7.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETS60797.1 - 0.002 18.2 4.6 0.77 10.0 0.0 4.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETS60797.1 - 0.0023 18.5 1.0 0.0089 16.7 2.7 8.3 8 3 2 10 10 9 4 Tetratricopeptide repeat Suf PF05843.14 ETS60797.1 - 0.0025 17.9 0.0 35 4.3 0.0 4.9 5 1 0 5 5 5 0 Suppressor of forked protein (Suf) TPR_15 PF13429.6 ETS60797.1 - 0.0039 16.5 24.7 0.012 14.8 1.6 5.2 3 2 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETS60797.1 - 0.01 15.5 0.0 0.19 11.5 0.2 3.1 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 ETS60797.1 - 0.12 12.8 0.0 33 5.2 0.1 4.8 3 0 0 3 3 3 0 Tetratricopeptide repeat FAT PF02259.23 ETS60797.1 - 0.27 10.4 5.2 1.1 8.4 1.2 3.2 3 1 0 4 4 4 0 FAT domain DER1 PF04511.15 ETS60798.1 - 3.6e-50 170.5 4.5 4.2e-50 170.4 4.5 1.0 1 0 0 1 1 1 1 Der1-like family DUF962 PF06127.11 ETS60799.1 - 3.4e-23 81.5 0.0 9.6e-23 80.1 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Nt_Gln_amidase PF09764.9 ETS60800.1 - 1.3e-54 184.7 0.0 5.5e-54 182.6 0.0 1.9 2 0 0 2 2 2 1 N-terminal glutamine amidase HAT_KAT11 PF08214.11 ETS60801.1 - 3.3e-31 108.9 0.0 1.9e-30 106.3 0.0 2.1 1 1 0 1 1 1 1 Histone acetylation protein NAD_synthase PF02540.17 ETS60801.1 - 0.19 10.8 0.0 0.32 10.1 0.0 1.2 1 0 0 1 1 1 0 NAD synthase Na_H_Exchanger PF00999.21 ETS60802.1 - 2.4e-68 230.7 17.2 3.1e-68 230.3 17.2 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF2207 PF09972.9 ETS60802.1 - 0.58 8.9 0.0 0.58 8.9 0.0 2.8 3 1 0 3 3 3 0 Predicted membrane protein (DUF2207) YrhC PF14143.6 ETS60802.1 - 0.7 10.0 1.9 1 9.5 0.4 2.0 2 0 0 2 2 2 0 YrhC-like protein XRN_M PF17846.1 ETS60802.1 - 0.9 8.4 4.6 1.5 7.7 4.6 1.2 1 0 0 1 1 1 0 Xrn1 helical domain PIG-F PF06699.11 ETS60803.1 - 4.2e-12 46.6 1.9 7.5e-12 45.8 1.9 1.5 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Ish1 PF10281.9 ETS60804.1 - 2.9e-66 219.5 30.0 1.3e-12 47.8 0.2 6.5 6 0 0 6 6 6 6 Putative stress-responsive nuclear envelope protein LEM PF03020.15 ETS60804.1 - 0.0004 19.9 0.0 27 4.4 0.0 4.9 5 0 0 5 5 5 1 LEM domain SAP PF02037.27 ETS60804.1 - 0.023 14.5 0.0 47 3.9 0.0 4.3 5 0 0 5 5 5 0 SAP domain TryThrA_C PF12319.8 ETS60804.1 - 0.1 12.1 8.3 0.053 13.0 4.9 2.1 1 1 1 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal ApoLp-III PF07464.11 ETS60804.1 - 0.76 9.9 7.7 1.8 8.7 5.8 2.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) zf-ANAPC11 PF12861.7 ETS60805.1 - 2.2e-32 111.0 11.0 2.9e-32 110.6 11.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ETS60805.1 - 4.1e-20 71.8 14.5 5.8e-20 71.3 14.5 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETS60805.1 - 1.5e-07 31.6 17.0 1.9e-06 28.1 17.0 2.1 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETS60805.1 - 0.0011 18.8 12.4 0.0047 16.8 12.4 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS60805.1 - 0.0011 18.8 18.9 0.0016 18.3 15.1 2.5 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS60805.1 - 0.0029 17.4 13.4 0.061 13.2 13.4 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS60805.1 - 0.046 13.7 11.1 0.17 11.9 11.2 1.9 1 1 0 1 1 1 0 RING-type zinc-finger Tax PF02959.16 ETS60805.1 - 0.11 11.9 0.8 0.14 11.6 0.8 1.1 1 0 0 1 1 1 0 HTLV Tax zf-RING_11 PF17123.5 ETS60805.1 - 0.11 12.2 14.0 2.4 8.0 14.0 2.3 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 ETS60805.1 - 0.2 11.6 14.5 1.2 9.2 14.7 2.0 1 1 1 2 2 2 0 zinc-RING finger domain zf-HC5HC2H_2 PF13832.6 ETS60805.1 - 0.29 11.3 9.1 0.14 12.3 7.2 1.5 1 1 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_4 PF14570.6 ETS60805.1 - 0.42 10.5 15.8 2.1 8.2 11.7 2.4 1 1 2 3 3 3 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 ETS60805.1 - 0.69 10.1 13.5 2.4 8.4 13.5 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain UPF0183 PF03676.14 ETS60806.1 - 1.2e-44 153.2 0.0 6.7e-14 52.0 0.0 4.4 4 1 0 4 4 4 4 Uncharacterised protein family (UPF0183) Syntaxin PF00804.25 ETS60807.1 - 0.0016 18.2 0.5 0.0028 17.4 0.5 1.3 1 0 0 1 1 1 1 Syntaxin Prominin PF05478.11 ETS60807.1 - 0.014 13.4 0.4 0.019 13.0 0.4 1.1 1 0 0 1 1 1 0 Prominin DUF1664 PF07889.12 ETS60807.1 - 0.016 15.3 0.0 0.036 14.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HisKA PF00512.25 ETS60807.1 - 0.07 13.2 1.9 0.52 10.4 0.4 2.3 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF2203 PF09969.9 ETS60807.1 - 0.075 13.8 0.4 0.075 13.8 0.4 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) ApoLp-III PF07464.11 ETS60807.1 - 0.083 13.0 1.6 4.7 7.3 0.0 2.2 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) CheZ PF04344.13 ETS60807.1 - 0.088 12.7 1.1 0.093 12.6 0.2 1.4 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ Syntaxin-6_N PF09177.11 ETS60807.1 - 0.13 12.9 0.4 0.77 10.3 0.3 2.0 2 0 0 2 2 2 0 Syntaxin 6, N-terminal FlaC_arch PF05377.11 ETS60807.1 - 0.26 11.7 0.9 0.86 10.0 0.1 2.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Nucleoporin_FG2 PF15967.5 ETS60807.1 - 0.76 8.2 8.9 0.85 8.1 8.9 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region DUF883 PF05957.13 ETS60807.1 - 5 7.8 11.9 3.6 8.2 4.5 2.7 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF883) G_glu_transpept PF01019.21 ETS60808.1 - 2.9e-160 534.4 0.0 3.5e-160 534.2 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase RRM_1 PF00076.22 ETS60809.1 - 5.8e-38 128.5 0.0 2.5e-15 56.1 0.0 4.7 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETS60809.1 - 4.3e-07 29.7 0.0 0.13 12.2 0.0 4.3 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ETS60809.1 - 3.2e-05 23.5 0.0 0.00019 21.0 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETS60809.1 - 0.0017 18.3 0.0 2.9 8.0 0.0 3.8 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ETS60809.1 - 0.0083 16.2 0.0 0.3 11.1 0.0 3.1 3 0 0 3 3 3 1 RNA binding motif RRM_7 PF16367.5 ETS60809.1 - 0.042 14.0 0.1 41 4.4 0.0 4.1 4 0 0 4 4 4 0 RNA recognition motif DUF5553 PF17707.1 ETS60810.1 - 0.23 10.9 1.3 0.41 10.1 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5553) Mitochondr_Som1 PF11093.8 ETS60813.1 - 6.2e-09 35.7 0.3 1.3e-08 34.7 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial export protein Som1 DUF2688 PF10892.8 ETS60814.1 - 0.12 11.8 0.1 0.32 10.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) PHD PF00628.29 ETS60815.1 - 7e-07 29.0 9.0 1.3e-06 28.2 9.0 1.5 1 0 0 1 1 1 1 PHD-finger Prok-RING_1 PF14446.6 ETS60815.1 - 0.00052 19.9 3.6 0.0011 18.9 3.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 SAP30_Sin3_bdg PF13867.6 ETS60815.1 - 0.003 17.8 0.0 0.0077 16.5 0.0 1.7 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-HC5HC2H PF13771.6 ETS60815.1 - 0.014 15.6 0.9 0.031 14.5 0.9 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain WSD PF15613.6 ETS60815.1 - 0.048 14.1 0.0 0.048 14.1 0.0 3.9 4 1 0 4 4 4 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif C1_2 PF03107.16 ETS60815.1 - 0.078 13.3 3.2 0.37 11.1 2.0 2.4 2 0 0 2 2 2 0 C1 domain RhoGEF PF00621.20 ETS60816.1 - 5.7e-19 69.1 0.0 1.2e-14 54.9 0.0 2.2 2 0 0 2 2 2 2 RhoGEF domain Malic_M PF03949.15 ETS60818.1 - 1.3e-86 290.1 0.0 1.7e-86 289.7 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ETS60818.1 - 1.2e-66 223.9 0.0 1.8e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain SSFA2_C PF14723.6 ETS60818.1 - 0.015 15.2 0.3 0.03 14.2 0.3 1.5 1 0 0 1 1 1 0 Sperm-specific antigen 2 C-terminus TPR_1 PF00515.28 ETS60819.1 - 5.8e-10 38.6 11.2 3.3e-05 23.5 1.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETS60819.1 - 1.3e-08 34.3 14.2 0.00075 19.4 1.7 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS60819.1 - 9.2e-08 32.1 3.7 9.2e-08 32.1 3.7 1.6 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETS60819.1 - 4.5e-06 26.9 3.9 4.5e-06 26.9 3.9 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 ETS60819.1 - 8.6e-06 24.4 0.2 1e-05 24.2 0.2 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal TPR_17 PF13431.6 ETS60819.1 - 3.4e-05 23.9 5.5 0.0086 16.4 0.7 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS60819.1 - 0.00022 21.7 8.2 0.00067 20.1 5.5 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETS60819.1 - 0.00027 20.3 3.0 0.25 10.5 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS60819.1 - 0.00033 21.3 6.8 0.00084 19.9 6.8 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS60819.1 - 0.00037 20.6 5.3 0.00064 19.9 5.0 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETS60819.1 - 0.00077 19.5 5.5 0.013 15.6 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETS60819.1 - 0.00084 19.2 2.8 0.43 10.7 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETS60819.1 - 0.00092 18.8 7.8 0.0016 18.0 2.5 3.2 3 1 0 3 3 3 1 TPR repeat TPR_6 PF13174.6 ETS60819.1 - 0.0014 19.1 3.8 0.47 11.2 0.4 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETS60819.1 - 0.011 16.5 8.3 0.028 15.2 2.0 2.9 2 1 1 3 3 2 0 Tetratricopeptide repeat DSPc PF00782.20 ETS60821.1 - 4.8e-26 91.1 0.1 9.7e-26 90.2 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETS60821.1 - 0.0035 16.9 0.0 0.0059 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 ETS60821.1 - 0.017 14.7 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 ETS60821.1 - 0.041 14.2 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 ETS60821.1 - 0.082 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family CUE PF02845.16 ETS60822.1 - 4.4e-10 39.1 0.0 7.5e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain DUF1296 PF06972.11 ETS60822.1 - 0.046 13.9 0.0 0.081 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Rsm22 PF09243.10 ETS60822.1 - 0.11 11.8 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial small ribosomal subunit Rsm22 zf-C2H2 PF00096.26 ETS60824.1 - 2.1e-06 27.9 16.2 0.00042 20.6 0.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETS60824.1 - 1.2e-05 25.5 4.9 1.2e-05 25.5 4.9 3.0 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETS60824.1 - 0.023 15.5 13.8 0.19 12.7 1.0 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HE PF16278.5 ETS60824.1 - 0.59 10.6 7.7 2.8 8.5 2.4 2.5 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 ETS60824.1 - 2.6 8.4 7.4 27 5.2 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Mg_trans_NIPA PF05653.14 ETS60825.1 - 1.9e-63 214.3 6.0 1.5e-60 204.8 4.6 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 ETS60825.1 - 0.00062 19.9 4.2 0.00062 19.9 4.2 3.4 3 1 0 3 3 3 1 EamA-like transporter family SPX PF03105.19 ETS60825.1 - 0.12 12.3 11.0 0.45 10.4 0.1 2.2 2 0 0 2 2 2 0 SPX domain Zip PF02535.22 ETS60825.1 - 2.2 7.4 11.3 0.85 8.8 4.5 2.8 3 0 0 3 3 3 0 ZIP Zinc transporter DUF4149 PF13664.6 ETS60825.1 - 8.1 6.8 6.8 41 4.6 0.1 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4149) CDC45 PF02724.14 ETS60825.1 - 8.8 4.5 6.8 2.5 6.3 0.7 2.0 2 0 0 2 2 2 0 CDC45-like protein Transgly_assoc PF04226.13 ETS60825.1 - 9.1 6.6 9.9 4.1 7.7 2.5 3.3 2 1 1 3 3 3 0 Transglycosylase associated protein Coprogen_oxidas PF01218.18 ETS60826.1 - 4.3e-124 413.0 0.0 1.2e-123 411.6 0.0 1.7 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase Lactonase PF10282.9 ETS60828.1 - 7.6e-72 242.4 0.5 1.2e-71 241.8 0.5 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF1772 PF08592.11 ETS60828.1 - 0.15 12.4 1.4 0.33 11.3 1.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Nup54 PF13874.6 ETS60829.1 - 9.8e-34 116.5 6.4 9.8e-34 116.5 6.4 2.7 2 1 1 3 3 3 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 ETS60829.1 - 0.0071 16.2 0.4 0.0071 16.2 0.4 2.6 2 0 0 2 2 2 1 Nup54 C-terminal interacting domain Atg14 PF10186.9 ETS60829.1 - 1.7 7.7 7.8 0.15 11.1 1.1 2.2 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1748 PF08520.10 ETS60830.1 - 8.7e-26 89.6 0.0 9.8e-26 89.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) LCAT PF02450.15 ETS60831.1 - 2.7e-07 30.1 0.0 4.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Abhydrolase_6 PF12697.7 ETS60831.1 - 9.3e-06 26.4 0.1 9.3e-06 26.4 0.1 2.3 3 0 0 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS60831.1 - 0.00096 18.5 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 ETS60831.1 - 0.024 14.4 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Pex14_N PF04695.13 ETS60832.1 - 7.7e-26 91.6 0.3 7.7e-26 91.6 0.3 3.0 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region CALCOCO1 PF07888.11 ETS60832.1 - 1.4e-05 24.2 6.5 2e-05 23.7 6.5 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Golgin_A5 PF09787.9 ETS60832.1 - 0.0033 16.9 4.9 0.0053 16.3 4.9 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 Fez1 PF06818.15 ETS60832.1 - 0.0048 17.4 4.0 0.0082 16.6 4.0 1.3 1 0 0 1 1 1 1 Fez1 MIP-T3_C PF17749.1 ETS60832.1 - 0.0064 16.5 2.4 0.33 10.9 1.1 2.4 2 0 0 2 2 2 1 Microtubule-binding protein MIP-T3 C-terminal region DUF3829 PF12889.7 ETS60832.1 - 0.011 15.2 1.0 0.019 14.4 0.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) IFT57 PF10498.9 ETS60832.1 - 0.013 14.5 0.7 0.021 13.8 0.7 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Spc7 PF08317.11 ETS60832.1 - 0.016 14.1 6.5 0.025 13.5 6.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 ETS60832.1 - 0.016 14.3 3.4 0.025 13.7 3.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 ETS60832.1 - 0.018 12.6 5.7 0.025 12.1 5.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 ETS60832.1 - 0.02 14.9 8.9 0.17 11.9 3.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 ETS60832.1 - 0.023 14.7 6.9 0.091 12.8 6.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) LXG PF04740.12 ETS60832.1 - 0.034 13.9 3.0 0.17 11.6 3.1 1.9 1 1 1 2 2 2 0 LXG domain of WXG superfamily Baculo_PEP_C PF04513.12 ETS60832.1 - 0.036 14.1 0.9 0.062 13.3 0.9 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 ETS60832.1 - 0.042 13.2 2.2 0.074 12.4 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Matrilin_ccoil PF10393.9 ETS60832.1 - 0.06 13.2 0.3 0.57 10.1 0.2 2.4 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin FTA4 PF13093.6 ETS60832.1 - 0.08 12.8 6.4 0.2 11.5 6.4 1.6 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DUF948 PF06103.11 ETS60832.1 - 0.088 13.1 2.9 6 7.2 1.3 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Vac_Fusion PF02346.16 ETS60832.1 - 0.091 12.4 0.2 0.33 10.6 0.2 1.9 3 0 0 3 3 1 0 Chordopoxvirus multifunctional envelope protein A27 DUF2968 PF11180.8 ETS60832.1 - 0.092 12.4 6.5 0.25 10.9 6.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) Enkurin PF13864.6 ETS60832.1 - 0.12 12.8 2.4 0.15 12.6 0.6 1.9 1 1 1 2 2 2 0 Calmodulin-binding FAP206 PF12018.8 ETS60832.1 - 0.12 11.9 0.4 3.7 7.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function Laminin_II PF06009.12 ETS60832.1 - 0.15 12.0 5.1 0.5 10.4 5.0 1.8 1 1 0 1 1 1 0 Laminin Domain II BshC PF10079.9 ETS60832.1 - 0.16 10.6 1.5 0.23 10.2 1.5 1.2 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC HemX PF04375.14 ETS60832.1 - 0.23 10.7 6.0 0.27 10.5 4.4 1.8 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase EzrA PF06160.12 ETS60832.1 - 0.26 9.4 6.9 2.6 6.1 7.5 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Spectrin PF00435.21 ETS60832.1 - 0.27 11.7 4.5 0.2 12.2 1.5 2.1 2 0 0 2 2 2 0 Spectrin repeat Sec20 PF03908.13 ETS60832.1 - 0.31 11.0 2.1 6.4 6.8 0.3 2.3 2 0 0 2 2 2 0 Sec20 KxDL PF10241.9 ETS60832.1 - 0.34 11.2 2.5 0.56 10.5 0.7 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein CEP63 PF17045.5 ETS60832.1 - 0.36 10.7 7.9 0.6 10.0 7.9 1.3 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa ERM PF00769.19 ETS60832.1 - 0.48 10.2 11.4 4.3 7.1 11.4 2.1 1 1 0 1 1 1 0 Ezrin/radixin/moesin family NPV_P10 PF05531.12 ETS60832.1 - 0.52 10.8 6.0 2.3e+02 2.3 6.0 2.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein CdvA PF18822.1 ETS60832.1 - 0.6 10.0 5.5 2.2 8.1 1.0 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Mt_ATP-synt_D PF05873.12 ETS60832.1 - 0.65 9.8 3.9 2.9 7.7 1.1 2.3 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF3450 PF11932.8 ETS60832.1 - 0.77 9.0 6.3 1.4 8.2 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 ETS60832.1 - 1.1 9.1 5.0 2.7 7.8 5.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) HIP1_clath_bdg PF16515.5 ETS60832.1 - 1.1 9.9 9.4 23 5.7 9.6 2.6 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 ETS60832.1 - 1.2 9.7 12.5 1.6 9.2 6.9 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF148 PF02520.17 ETS60832.1 - 1.3 9.2 4.8 2.4 8.3 1.3 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 Med9 PF07544.13 ETS60832.1 - 1.4 9.1 5.4 13 5.9 0.5 2.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HALZ PF02183.18 ETS60832.1 - 1.5 9.1 7.5 0.97 9.7 0.6 2.5 2 0 0 2 2 2 0 Homeobox associated leucine zipper COG2 PF06148.11 ETS60832.1 - 2.3 8.3 7.0 3.6 7.7 3.1 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 ETS60832.1 - 5.7 6.1 4.8 11 5.2 4.8 1.4 1 1 0 1 1 1 0 TMPIT-like protein RNA_pol_L_2 PF13656.6 ETS60833.1 - 1.1e-29 101.9 0.0 1.4e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ETS60833.1 - 1e-11 44.1 0.0 1.4e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain MBOAT_2 PF13813.6 ETS60834.1 - 6.7e-14 51.9 5.6 6.7e-14 51.9 5.6 2.1 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Myb_DNA-bind_6 PF13921.6 ETS60835.1 - 3.6e-17 62.4 0.0 4.6e-08 33.2 0.0 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ETS60835.1 - 4.2e-17 62.0 0.0 8.2e-09 35.5 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 ETS60835.1 - 0.0039 17.2 0.0 0.54 10.3 0.0 2.6 2 0 0 2 2 2 1 SLIDE Dcc1 PF09724.9 ETS60835.1 - 1.7 7.9 5.5 3 7.0 5.5 1.3 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 CTU2 PF10288.9 ETS60836.1 - 4.9e-31 107.3 0.3 2.4e-29 101.9 0.0 2.6 2 0 0 2 2 2 2 Cytoplasmic tRNA 2-thiolation protein 2 Peptidase_M22 PF00814.25 ETS60837.1 - 5.5e-77 259.1 0.0 8.3e-55 186.4 0.0 2.7 2 0 0 2 2 2 2 Glycoprotease family APG5 PF04106.12 ETS60837.1 - 3.3e-64 216.6 0.0 3.3e-64 216.6 0.0 2.4 2 1 0 2 2 2 1 Autophagy protein Apg5 TFIID_20kDa PF03847.13 ETS60837.1 - 1.4e-29 102.4 1.4 2.7e-29 101.5 1.4 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-31kDa PF02291.15 ETS60837.1 - 0.034 14.2 3.6 0.058 13.5 0.0 2.6 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit SRP-alpha_N PF04086.13 ETS60838.1 - 0.32 10.9 24.8 0.32 10.9 7.3 2.4 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal CBF PF03914.17 ETS60839.1 - 3.1e-28 98.9 0.3 1.4e-27 96.8 0.2 2.2 2 0 0 2 2 2 1 CBF/Mak21 family Pkinase PF00069.25 ETS60840.1 - 2.2e-57 194.4 0.0 4.4e-57 193.5 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60840.1 - 1.8e-18 66.8 0.4 8.7e-18 64.5 0.4 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETS60840.1 - 0.0026 17.1 0.1 0.0045 16.4 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Phage_sheath_1C PF17482.2 ETS60840.1 - 0.036 14.0 0.1 0.096 12.7 0.0 1.7 2 0 0 2 2 2 0 Phage tail sheath C-terminal domain Kinase-like PF14531.6 ETS60840.1 - 0.12 11.6 0.1 0.63 9.3 0.1 2.1 1 1 0 2 2 2 0 Kinase-like EphA2_TM PF14575.6 ETS60841.1 - 0.055 14.3 2.4 0.068 14.1 0.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Rax2 PF12768.7 ETS60841.1 - 0.21 11.0 0.0 0.35 10.3 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity RCR PF12273.8 ETS60841.1 - 7.3 7.3 6.9 89 3.8 0.0 2.6 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red LPD23 PF18838.1 ETS60842.1 - 0.11 12.3 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 Tyr_Deacylase PF02580.16 ETS60843.1 - 1.2e-46 158.9 0.0 5.9e-46 156.6 0.0 1.9 1 1 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase DUF4112 PF13430.6 ETS60845.1 - 4.7e-31 107.2 0.0 6.3e-31 106.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) WD40 PF00400.32 ETS60846.1 - 1.1e-07 32.4 3.4 0.00049 20.8 0.0 4.7 4 0 0 4 4 4 1 WD domain, G-beta repeat PQQ_3 PF13570.6 ETS60846.1 - 1 10.0 5.7 18 6.0 0.1 4.9 5 1 0 5 5 5 0 PQQ-like domain Syntaxin_2 PF14523.6 ETS60847.1 - 2.2e-19 69.7 6.4 3.9e-19 68.9 1.7 2.5 2 1 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 ETS60847.1 - 9e-11 41.6 0.7 9e-11 41.6 0.7 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ETS60847.1 - 0.00041 20.1 7.4 0.0011 18.7 0.1 2.3 2 0 0 2 2 2 1 Syntaxin Serine_rich PF08824.10 ETS60847.1 - 0.0025 17.8 2.7 0.13 12.3 2.6 2.2 2 0 0 2 2 2 1 Serine rich protein interaction domain DUF16 PF01519.16 ETS60847.1 - 7.5 7.1 10.4 0.67 10.5 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function DUF16 S4 PF01479.25 ETS60848.1 - 4.2e-12 45.6 0.0 7.5e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_S4 PF00163.19 ETS60848.1 - 8.5e-11 42.6 0.4 1.5e-10 41.9 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain ATPase PF06745.13 ETS60850.1 - 0.11 11.8 0.0 0.34 10.2 0.0 1.5 1 1 0 1 1 1 0 KaiC Noc2 PF03715.13 ETS60851.1 - 1.5e-106 356.0 1.2 2.3e-106 355.4 1.2 1.3 1 0 0 1 1 1 1 Noc2p family GTP_EFTU PF00009.27 ETS60852.1 - 4e-29 101.5 5.5 1.1e-27 96.9 3.7 3.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ETS60852.1 - 8e-25 87.0 0.6 1.9e-24 85.8 0.6 1.6 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 ETS60852.1 - 8.9e-07 29.0 0.2 2.1e-06 27.8 0.2 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETS60852.1 - 0.00028 20.4 0.2 0.0013 18.3 0.2 2.2 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ETS60852.1 - 0.0014 18.6 0.0 1.1 9.1 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase IF2_N PF04760.15 ETS60852.1 - 0.013 15.3 0.3 0.042 13.7 0.0 2.0 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region SRPRB PF09439.10 ETS60852.1 - 0.019 14.4 1.1 0.03 13.7 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 ETS60852.1 - 0.15 12.6 2.9 4.9 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF3545 PF12065.8 ETS60852.1 - 0.74 9.9 4.5 2 8.5 4.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) Fez1 PF06818.15 ETS60853.1 - 5.2e-05 23.8 30.3 0.0029 18.1 5.8 3.8 2 1 1 3 3 3 2 Fez1 DUF773 PF05600.12 ETS60853.1 - 0.0028 16.5 0.1 0.0028 16.5 0.1 1.8 2 0 0 2 2 2 1 CDK5 regulatory subunit-associated protein 3 Spc7 PF08317.11 ETS60853.1 - 0.58 9.0 25.0 0.13 11.2 8.9 2.9 2 1 0 2 2 2 0 Spc7 kinetochore protein DUF4201 PF13870.6 ETS60853.1 - 0.66 9.7 11.7 4.2 7.1 0.2 4.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) SHE3 PF17078.5 ETS60853.1 - 4.8 6.8 11.2 4.9 6.8 0.5 2.7 3 0 0 3 3 3 0 SWI5-dependent HO expression protein 3 CorA PF01544.18 ETS60853.1 - 9.9 5.4 7.5 0.39 10.0 1.3 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein RRM_1 PF00076.22 ETS60854.1 - 7.9e-74 243.5 3.7 7.6e-19 67.3 0.0 6.1 7 0 0 7 7 7 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETS60854.1 - 8.7e-09 35.1 0.0 0.22 11.4 0.0 5.2 5 0 0 5 5 5 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ETS60854.1 - 2.4e-07 30.4 0.0 0.037 13.6 0.0 4.1 4 1 0 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETS60854.1 - 0.00045 20.2 0.0 0.98 9.5 0.0 3.4 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_2 PF04059.12 ETS60854.1 - 0.00052 20.2 0.0 1.1 9.5 0.0 3.9 4 0 0 4 4 4 1 RNA recognition motif 2 RRM_7 PF16367.5 ETS60854.1 - 0.00065 19.8 0.0 7 6.9 0.0 4.1 4 0 0 4 4 4 2 RNA recognition motif Limkain-b1 PF11608.8 ETS60854.1 - 0.021 14.9 0.3 0.38 10.9 0.0 3.4 4 0 0 4 4 4 0 Limkain b1 HTH_CodY PF08222.11 ETS60854.1 - 0.18 11.4 0.1 0.38 10.4 0.1 1.4 1 0 0 1 1 1 0 CodY helix-turn-helix domain DUF89 PF01937.19 ETS60855.1 - 1.3e-110 369.7 0.0 1.5e-110 369.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Got1 PF04178.12 ETS60856.1 - 1.9e-31 108.8 11.3 2.9e-31 108.2 11.3 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2070 PF09843.9 ETS60856.1 - 0.019 13.3 4.8 0.022 13.1 4.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4396 PF14342.6 ETS60856.1 - 0.68 10.3 4.8 1.1 9.6 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4396) Cpn60_TCP1 PF00118.24 ETS60857.1 - 3e-162 540.7 5.5 3.5e-162 540.4 5.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mito_carr PF00153.27 ETS60858.1 - 1.2e-73 243.1 4.3 3.6e-24 84.5 0.0 4.6 4 0 0 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 ETS60858.1 - 0.0078 15.4 1.3 1.4 8.0 0.1 3.2 1 1 2 3 3 3 2 Gammaproteobacterial serine protease SPX PF03105.19 ETS60858.1 - 0.16 11.9 2.0 0.21 11.5 2.0 1.4 1 0 0 1 1 1 0 SPX domain Ribosomal_L21e PF01157.18 ETS60859.1 - 9.4e-44 147.4 3.7 9.4e-44 147.4 3.7 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e DUF3987 PF13148.6 ETS60859.1 - 0.091 11.8 0.6 0.12 11.4 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) S4 PF01479.25 ETS60861.1 - 1.1e-10 41.1 0.7 1.1e-10 41.1 0.7 3.2 4 0 0 4 4 4 1 S4 domain Ribosomal_S4 PF00163.19 ETS60861.1 - 3.1e-06 28.0 0.0 5.5e-06 27.2 0.0 1.6 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain DNA_repr_REX1B PF14966.6 ETS60862.1 - 1.2e-08 35.5 3.7 0.0006 20.4 0.7 2.9 3 0 0 3 3 3 2 DNA repair REX1-B LEH PF07858.12 ETS60862.1 - 0.014 15.5 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Limonene-1,2-epoxide hydrolase catalytic domain Filament PF00038.21 ETS60862.1 - 0.021 14.4 3.2 0.027 14.1 3.2 1.2 1 0 0 1 1 1 0 Intermediate filament protein eIF-4B PF06273.11 ETS60862.1 - 0.087 11.9 0.3 0.15 11.1 0.3 1.3 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B CENP-H PF05837.12 ETS60862.1 - 0.14 12.6 4.2 0.22 11.9 3.9 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) LSM PF01423.22 ETS60863.1 - 2.8e-19 68.6 0.2 3.4e-19 68.3 0.2 1.1 1 0 0 1 1 1 1 LSM domain FoP_duplication PF13865.6 ETS60863.1 - 1.7 9.3 15.9 3.3 8.3 15.9 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Glyco_hydro_35 PF01301.19 ETS60864.1 - 4.4e-75 253.2 0.0 6.6e-75 252.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 ETS60864.1 - 2.3e-51 173.2 2.5 1.3e-27 96.6 0.5 3.1 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 ETS60864.1 - 6.5e-12 45.6 0.0 1.4e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 Cellulase PF00150.18 ETS60864.1 - 8.9e-06 25.3 0.0 0.00021 20.8 0.0 2.5 3 0 0 3 3 3 1 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 ETS60865.1 - 4e-67 226.4 0.0 5e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60865.1 - 2.8e-32 112.0 0.0 3.6e-32 111.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETS60865.1 - 1.2e-05 24.5 0.1 1.6e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETS60865.1 - 0.00041 19.8 0.0 0.0011 18.3 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETS60865.1 - 0.00068 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETS60865.1 - 0.0066 15.8 0.0 0.041 13.2 0.0 2.0 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 ETS60865.1 - 0.014 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ETS60865.1 - 0.017 14.7 0.0 0.054 13.1 0.0 1.7 2 0 0 2 2 2 0 RIO1 family muHD PF10291.9 ETS60867.1 - 9.8e-54 182.5 0.0 1.5e-53 182.0 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 ETS60867.1 - 9.6e-08 32.2 0.0 9.6e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Mod_r PF07200.13 ETS60867.1 - 1.1 9.4 11.2 0.054 13.6 4.1 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein eIF2_C PF09173.11 ETS60868.1 - 7.6e-37 125.4 0.2 2.3e-36 123.9 0.2 1.9 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 ETS60868.1 - 1.8e-21 76.6 1.2 1.9e-20 73.3 1.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ETS60868.1 - 2.1e-13 50.5 0.4 2.1e-13 50.5 0.4 2.2 3 0 0 3 3 3 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 ETS60868.1 - 0.00094 19.1 0.6 0.025 14.5 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETS60868.1 - 0.0045 17.1 0.0 0.01 15.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 ETS60868.1 - 0.012 15.6 0.8 0.055 13.5 0.1 2.3 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Dynamin_N PF00350.23 ETS60868.1 - 0.099 12.7 0.2 0.24 11.4 0.2 1.9 1 1 0 1 1 1 0 Dynamin family ATP_sub_h PF10775.9 ETS60869.1 - 5.1e-23 80.8 2.2 7.4e-23 80.3 2.2 1.3 1 0 0 1 1 1 1 ATP synthase complex subunit h IATP PF04568.12 ETS60870.1 - 1.5e-13 51.0 1.3 1.7e-13 50.8 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP MOFRL PF05161.13 ETS60870.1 - 0.0016 18.6 0.1 0.0019 18.4 0.1 1.3 1 1 0 1 1 1 1 MOFRL family UPF0449 PF15136.6 ETS60870.1 - 0.0052 17.2 1.7 0.0066 16.9 1.7 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 Caudo_TAP PF02413.17 ETS60870.1 - 0.019 15.1 2.4 0.023 14.9 2.4 1.3 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK DUF1366 PF07104.11 ETS60870.1 - 0.036 13.8 4.8 0.047 13.4 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) DUF2779 PF11074.8 ETS60870.1 - 0.063 13.8 0.2 0.069 13.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function(DUF2779) OSTbeta PF15048.6 ETS60870.1 - 0.068 13.3 3.6 0.083 13.0 3.6 1.1 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein DUF4140 PF13600.6 ETS60870.1 - 0.16 12.4 4.1 0.11 13.0 3.0 1.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Atg14 PF10186.9 ETS60870.1 - 0.4 9.7 7.2 0.46 9.5 7.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_12 PF13087.6 ETS60871.1 - 1.5e-53 181.4 0.0 3.5e-53 180.2 0.0 1.6 2 0 0 2 2 2 1 AAA domain PS_Dcarbxylase PF02666.15 ETS60871.1 - 6.9e-44 149.8 0.0 1.1e-43 149.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase AAA_11 PF13086.6 ETS60871.1 - 5.3e-42 144.4 1.9 6.6e-42 144.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ETS60871.1 - 3.5e-14 53.4 0.0 1.9e-13 51.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS60871.1 - 8.9e-12 45.1 0.0 1.9e-08 34.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ETS60871.1 - 0.0015 18.3 0.0 16 5.2 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 ETS60871.1 - 0.0036 17.3 0.0 0.0085 16.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ETS60871.1 - 0.0059 16.2 0.2 0.025 14.1 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 ETS60871.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein NAPRTase_C PF17956.1 ETS60871.1 - 0.15 12.5 0.0 0.53 10.7 0.0 1.9 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain AAA_7 PF12775.7 ETS60871.1 - 0.2 11.2 0.0 0.35 10.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region HMG_box PF00505.19 ETS60872.1 - 8.3e-24 83.8 1.1 1.7e-23 82.8 1.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS60872.1 - 8e-18 64.8 1.5 1.7e-17 63.7 1.5 1.6 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 ETS60872.1 - 0.0017 18.3 0.0 0.0029 17.5 0.0 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 ETS60872.1 - 0.029 14.9 0.1 0.054 14.1 0.1 1.4 1 0 0 1 1 1 0 YABBY protein RR_TM4-6 PF06459.12 ETS60872.1 - 0.55 10.0 3.3 1 9.1 3.3 1.4 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 Mito_carr PF00153.27 ETS60873.1 - 2e-61 203.9 3.4 7.5e-22 77.1 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Fucose_iso_C PF02952.17 ETS60873.1 - 0.094 12.4 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain Tmemb_14 PF03647.13 ETS60873.1 - 0.44 11.3 3.9 11 6.9 0.0 3.5 3 1 0 3 3 3 0 Transmembrane proteins 14C SRP9-21 PF05486.12 ETS60874.1 - 1.5e-07 31.7 0.9 1.5e-07 31.7 0.9 3.5 3 1 0 3 3 3 1 Signal recognition particle 9 kDa protein (SRP9) RINGv PF12906.7 ETS60875.1 - 4.8e-06 26.6 6.3 1.3e-05 25.3 6.3 1.7 1 1 0 1 1 1 1 RING-variant domain zf-RING_4 PF14570.6 ETS60875.1 - 0.083 12.7 1.6 0.17 11.7 1.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 ETS60875.1 - 0.91 9.4 3.9 1.5 8.7 3.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS60875.1 - 1.3 9.5 10.3 3.7 7.9 10.3 1.8 1 1 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 ETS60875.1 - 2.9 8.2 5.9 5.8 7.3 5.9 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain PHD_4 PF16866.5 ETS60875.1 - 3.8 7.7 6.3 6.8 6.9 6.3 1.3 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 ETS60875.1 - 3.9 7.2 7.1 0.24 11.0 1.7 1.8 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type 2OG-FeII_Oxy_2 PF13532.6 ETS60876.1 - 4.6e-13 49.8 0.0 1.1e-12 48.6 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Antimicrobial14 PF08109.11 ETS60876.1 - 0.24 11.5 0.2 14 5.8 0.0 2.4 2 0 0 2 2 2 0 Lactocin 705 family RVT_1 PF00078.27 ETS60878.1 - 6.3e-13 48.7 0.0 7.2e-13 48.6 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Vps35 PF03635.17 ETS60879.1 - 0 1026.0 0.0 0 1025.3 0.0 1.3 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 Totivirus_coat PF05518.11 ETS60879.1 - 0.94 7.5 15.7 1.8 6.5 15.7 1.5 1 0 0 1 1 1 0 Totivirus coat protein MT-A70 PF05063.14 ETS60880.1 - 7.1e-46 156.3 0.0 9.3e-46 155.9 0.0 1.1 1 0 0 1 1 1 1 MT-A70 WD40 PF00400.32 ETS60881.1 - 4.2e-15 55.9 5.7 0.0055 17.5 0.0 7.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60881.1 - 8.2e-12 45.3 0.0 2.3e-06 27.8 0.0 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETS60881.1 - 9.3e-05 22.3 0.4 0.049 13.6 0.2 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETS60881.1 - 9.9e-05 22.3 0.4 0.049 13.5 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETS60881.1 - 0.037 13.0 0.0 8.9 5.2 0.0 3.0 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein tRNA_int_endo PF01974.17 ETS60882.1 - 4.1e-20 71.6 0.0 8.4e-20 70.6 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 ETS60882.1 - 1e-05 25.1 0.0 0.00016 21.2 0.0 2.2 2 0 0 2 2 2 1 tRNA intron endonuclease, N-terminal domain Myc_N PF01056.18 ETS60882.1 - 0.034 14.1 0.7 0.061 13.2 0.7 1.5 1 0 0 1 1 1 0 Myc amino-terminal region Complex1_LYR PF05347.15 ETS60883.1 - 6.2e-10 39.0 8.3 5.3e-09 36.0 5.5 2.2 2 0 0 2 2 2 2 Complex 1 protein (LYR family) RRM_1 PF00076.22 ETS60884.1 - 4.5e-17 61.6 0.0 7.2e-17 61.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Bromo_TP PF07524.13 ETS60885.1 - 9.1e-12 44.8 0.0 2.5e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Bromodomain associated FlxA PF14282.6 ETS60885.1 - 3.5 7.7 12.1 0.035 14.1 1.7 2.5 2 0 0 2 2 2 0 FlxA-like protein Oxidored_molyb PF00174.19 ETS60886.1 - 1.1e-43 148.8 0.0 1.8e-43 148.2 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ETS60886.1 - 7.6e-14 51.9 0.6 4e-13 49.6 0.6 2.0 1 1 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain SE PF08491.10 ETS60887.1 - 2.2e-99 332.0 0.0 3.9e-99 331.2 0.0 1.3 1 1 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 ETS60887.1 - 1.8e-11 43.9 0.0 3.5e-11 42.9 0.0 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETS60887.1 - 2.7e-09 37.1 0.3 6e-06 26.1 0.0 2.5 2 1 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS60887.1 - 4.6e-05 23.6 0.3 0.00011 22.4 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETS60887.1 - 0.0031 16.7 0.3 0.04 13.0 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain ApbA PF02558.16 ETS60887.1 - 0.0042 16.7 0.0 0.0069 16.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 ETS60887.1 - 0.0068 15.7 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ETS60887.1 - 0.0087 15.3 0.1 0.018 14.3 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETS60887.1 - 0.012 14.7 0.0 0.022 13.8 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A NAD_Gly3P_dh_N PF01210.23 ETS60887.1 - 0.029 14.3 0.0 0.059 13.3 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pyr_redox PF00070.27 ETS60887.1 - 0.045 14.3 0.1 0.15 12.7 0.1 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ETS60887.1 - 0.081 12.8 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 ETS60887.1 - 0.098 12.0 0.1 0.15 11.4 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_2 PF03446.15 ETS60887.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HI0933_like PF03486.14 ETS60887.1 - 0.16 10.7 0.0 0.44 9.2 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Ubiq_cyt_C_chap PF03981.12 ETS60888.1 - 0.0018 18.3 0.0 0.7 10.0 0.1 2.5 2 0 0 2 2 2 2 Ubiquinol-cytochrome C chaperone T3SS_needle_reg PF09025.10 ETS60888.1 - 0.022 14.7 0.0 0.1 12.6 0.0 2.1 2 0 0 2 2 2 0 YopR, type III needle-polymerisation regulator Bap31 PF05529.12 ETS60889.1 - 6.7e-48 162.0 7.1 6.7e-48 162.0 7.1 1.3 2 0 0 2 2 2 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 ETS60889.1 - 3.4e-08 33.4 9.5 7.6e-08 32.2 9.6 1.5 1 1 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4446 PF14584.6 ETS60889.1 - 0.0031 17.5 1.5 0.0051 16.8 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF4446) adh_short PF00106.25 ETS60890.1 - 3.7e-39 134.2 0.1 4.4e-39 134.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS60890.1 - 2e-29 102.8 0.0 2.5e-29 102.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS60890.1 - 0.00013 21.9 0.2 0.0002 21.4 0.2 1.2 1 0 0 1 1 1 1 KR domain DUF562 PF04763.12 ETS60890.1 - 0.0071 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF562) Epimerase PF01370.21 ETS60890.1 - 0.0086 15.6 0.0 0.018 14.5 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ETS60890.1 - 0.026 13.9 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 3HCDH_N PF02737.18 ETS60890.1 - 0.15 12.0 0.1 0.23 11.3 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ferric_reduct PF01794.19 ETS60891.1 - 7.1e-22 77.8 5.7 7.1e-22 77.8 5.7 3.4 4 0 0 4 4 4 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ETS60891.1 - 5.1e-15 55.9 0.0 2.7e-14 53.6 0.0 2.0 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ETS60891.1 - 4.2e-14 52.6 0.0 1.1e-13 51.2 0.0 1.7 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 ETS60891.1 - 1.4e-05 25.7 0.0 0.066 13.9 0.0 2.4 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain TBP PF00352.21 ETS60892.1 - 4.2e-66 218.9 0.2 2.4e-32 110.7 0.1 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 ETS60892.1 - 1.3e-05 25.2 0.0 0.19 11.8 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 ETS60892.1 - 0.11 12.3 0.1 0.62 9.9 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) NUDIX_2 PF13869.6 ETS60893.1 - 3.2e-78 261.7 0.0 3.6e-78 261.5 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase DUF883 PF05957.13 ETS60894.1 - 0.02 15.5 3.3 0.053 14.1 3.3 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Adeno_VII PF03228.14 ETS60894.1 - 0.098 13.3 0.3 0.18 12.4 0.3 1.4 1 0 0 1 1 1 0 Adenoviral core protein VII Macoilin PF09726.9 ETS60894.1 - 2.9 6.4 9.4 3.7 6.0 9.4 1.1 1 0 0 1 1 1 0 Macoilin family OPA3 PF07047.12 ETS60895.1 - 7.3e-43 145.3 1.7 7.3e-43 145.3 1.7 1.5 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) Glyco_transf_20 PF00982.21 ETS60896.1 - 6e-153 509.9 0.0 8.2e-153 509.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ETS60896.1 - 6.9e-18 64.6 0.0 1.3e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Pkinase PF00069.25 ETS60898.1 - 1.2e-38 133.0 0.0 2.8e-37 128.5 0.0 2.4 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60898.1 - 9.9e-25 87.3 0.0 1.9e-24 86.4 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS60898.1 - 0.0028 17.0 0.0 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETS60898.1 - 0.03 13.7 0.0 0.066 12.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CCDC53 PF10152.9 ETS60898.1 - 0.78 10.1 2.2 2.3 8.6 2.2 1.7 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex SOBP PF15279.6 ETS60899.1 - 0.39 11.3 3.0 0.49 10.9 3.0 1.0 1 0 0 1 1 1 0 Sine oculis-binding protein OTU PF02338.19 ETS60900.1 - 5e-13 49.7 0.0 1.1e-12 48.5 0.0 1.6 1 0 0 1 1 1 1 OTU-like cysteine protease AT_hook PF02178.19 ETS60900.1 - 0.53 10.3 5.7 1.4 9.1 5.7 1.8 1 0 0 1 1 1 0 AT hook motif RPA_interact_C PF14768.6 ETS60901.1 - 0.025 15.1 0.3 0.041 14.4 0.3 1.3 1 0 0 1 1 1 0 Replication protein A interacting C-terminal ox_reductase_C PF08635.10 ETS60902.1 - 5.8e-77 256.2 0.1 8.5e-77 255.6 0.1 1.3 1 0 0 1 1 1 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA PF01408.22 ETS60902.1 - 4.7e-28 98.4 0.0 8.1e-28 97.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ETS60902.1 - 0.0089 16.0 0.0 0.022 14.7 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain SasG_E PF17041.5 ETS60902.1 - 0.28 11.2 2.3 0.4 10.7 0.6 2.1 2 0 0 2 2 2 0 E domain Cofilin_ADF PF00241.20 ETS60903.1 - 5.4e-20 71.4 0.0 6e-20 71.3 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein TraX PF05857.11 ETS60903.1 - 0.051 13.6 0.0 0.067 13.2 0.0 1.1 1 0 0 1 1 1 0 TraX protein CTNNBL PF08216.11 ETS60905.1 - 9.8e-33 112.4 0.0 2.2e-32 111.3 0.0 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear HEAT_2 PF13646.6 ETS60905.1 - 0.04 14.3 0.8 0.04 14.3 0.8 4.1 3 1 0 3 3 3 0 HEAT repeats Drf_GBD PF06371.13 ETS60905.1 - 0.064 12.8 0.0 0.89 9.1 0.0 2.4 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain RRM_1 PF00076.22 ETS60906.1 - 4.4e-16 58.5 0.0 7.7e-16 57.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ADH_zinc_N_2 PF13602.6 ETS60907.1 - 1.7e-09 38.8 0.0 4.7e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS60907.1 - 1.3e-05 25.0 0.2 3.1e-05 23.8 0.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS60907.1 - 0.0094 15.9 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Red1 PF07964.11 ETS60907.1 - 3.1 5.9 6.0 5.8 5.0 6.0 1.3 1 0 0 1 1 1 0 Rec10 / Red1 GTP_EFTU PF00009.27 ETS60910.1 - 8.5e-55 185.3 0.1 1.8e-54 184.2 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ETS60910.1 - 4.1e-14 52.4 0.0 9.5e-14 51.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ETS60910.1 - 2.2e-08 34.1 0.0 6e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ETS60910.1 - 0.00023 21.2 0.0 0.00062 19.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_IV PF03764.18 ETS60910.1 - 0.0016 18.2 0.0 0.0055 16.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 ETS60910.1 - 0.0042 17.5 0.0 0.012 16.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Nop25 PF09805.9 ETS60910.1 - 0.68 10.4 10.6 1.6 9.2 3.5 2.6 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) PPP4R2 PF09184.11 ETS60910.1 - 4.6 6.7 11.8 0.7 9.4 0.7 2.3 2 0 0 2 2 2 0 PPP4R2 XRN_M PF17846.1 ETS60910.1 - 4.7 6.1 8.7 0.3 10.0 3.4 1.6 2 0 0 2 2 2 0 Xrn1 helical domain WD40 PF00400.32 ETS60911.1 - 3.9e-38 128.7 15.6 3.6e-07 30.8 0.4 7.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS60911.1 - 6.9e-11 42.3 0.0 0.1 12.9 0.0 4.6 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS60911.1 - 3.2e-06 26.4 0.2 0.0056 15.7 0.0 3.1 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETS60911.1 - 1.1e-05 24.1 0.0 1.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETS60911.1 - 2.6e-05 23.7 0.0 0.45 9.8 0.0 3.1 3 0 0 3 3 3 3 WD40-like domain Frtz PF11768.8 ETS60911.1 - 0.0011 17.4 0.0 0.011 14.1 0.0 2.4 3 1 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETS60911.1 - 0.056 12.2 0.1 0.19 10.4 0.1 2.0 1 1 0 1 1 1 0 Nup133 N terminal like Nup160 PF11715.8 ETS60911.1 - 0.097 11.3 0.3 3.9 6.0 0.1 3.0 3 1 0 3 3 3 0 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETS60911.1 - 0.1 11.9 0.0 0.97 8.7 0.0 2.4 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Cauli_VI PF01693.16 ETS60913.1 - 3.6e-10 40.0 0.0 6.4e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin Glyoxalase PF00903.25 ETS60913.1 - 0.015 15.5 0.0 0.04 14.1 0.0 1.7 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KCH PF16944.5 ETS60914.1 - 2.3e-86 289.7 12.5 3e-86 289.3 12.5 1.1 1 0 0 1 1 1 1 Fungal potassium channel Mito_carr PF00153.27 ETS60915.1 - 1.9e-53 178.3 7.1 2.8e-17 62.4 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein NOG1_N PF17835.1 ETS60916.1 - 4.3e-48 163.3 0.1 4.3e-48 163.3 0.1 2.1 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 ETS60916.1 - 6.2e-27 93.4 4.0 1.5e-26 92.1 4.0 1.7 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 ETS60916.1 - 1.1e-26 92.3 0.1 2.4e-26 91.3 0.1 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 ETS60916.1 - 5.1e-18 65.2 0.0 1.3e-17 63.9 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETS60916.1 - 3e-08 33.4 0.0 6.4e-08 32.3 0.0 1.5 1 1 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 ETS60916.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 ETS60916.1 - 0.02 14.9 0.9 1.5 8.8 0.0 3.0 2 1 1 3 3 3 0 Dynamin family Roc PF08477.13 ETS60916.1 - 0.098 12.9 0.0 0.51 10.6 0.0 2.1 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETS60916.1 - 0.11 12.4 0.0 1.1 9.1 0.0 2.7 2 1 0 2 2 2 0 RsgA GTPase DUF4683 PF15735.5 ETS60916.1 - 3 7.4 8.9 5.3 6.6 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) Aldedh PF00171.22 ETS60918.1 - 5.2e-108 361.5 0.0 6.3e-108 361.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LSM PF01423.22 ETS60919.1 - 5.6e-20 70.8 0.7 6.7e-20 70.5 0.7 1.1 1 0 0 1 1 1 1 LSM domain DUF765 PF05570.11 ETS60919.1 - 4.9 7.4 7.7 0.43 10.8 2.7 1.8 2 0 0 2 2 2 0 Circovirus protein of unknown function (DUF765) Ribosomal_L5_C PF00673.21 ETS60920.1 - 4.1e-18 65.3 0.0 6.1e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ETS60920.1 - 3.1e-06 27.4 0.9 0.00036 20.8 0.0 2.5 2 0 0 2 2 2 2 Ribosomal protein L5 Cullin_binding PF03556.15 ETS60921.1 - 5.6e-34 117.2 1.6 1e-33 116.3 1.6 1.5 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 ETS60921.1 - 2.8e-07 30.2 0.1 6.3e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain YtzH PF14165.6 ETS60921.1 - 0.065 13.6 0.1 14 6.1 0.0 3.3 3 1 0 3 3 3 0 YtzH-like protein ERp29 PF07749.12 ETS60921.1 - 0.16 12.9 0.1 0.16 12.9 0.1 2.2 2 1 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain TipAS PF07739.13 ETS60921.1 - 6.9 7.2 9.3 0.72 10.4 2.2 2.7 3 0 0 3 3 3 0 TipAS antibiotic-recognition domain Iso_dh PF00180.20 ETS60922.1 - 1.3e-113 379.8 0.0 1.5e-113 379.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase zf-RING_2 PF13639.6 ETS60923.1 - 7.7e-12 45.4 4.0 1.2e-11 44.7 4.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETS60923.1 - 6.2e-10 38.6 2.0 6.2e-10 38.6 2.0 2.0 2 0 0 2 2 2 1 RING-like zinc finger PA PF02225.22 ETS60923.1 - 1.3e-07 31.5 0.0 4.5e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 PA domain zf-RING_5 PF14634.6 ETS60923.1 - 1.8e-05 24.6 1.6 2.8e-05 24.0 1.6 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS60923.1 - 6.3e-05 22.7 3.2 9.8e-05 22.1 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS60923.1 - 0.00042 20.1 1.3 0.00065 19.5 1.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS60923.1 - 0.001 19.0 8.8 0.0014 18.6 0.4 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 ETS60923.1 - 0.0016 18.7 5.0 0.0052 17.0 5.0 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETS60923.1 - 0.0017 18.1 2.4 0.003 17.4 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS60923.1 - 0.0054 16.6 3.9 0.0092 15.8 3.9 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETS60923.1 - 0.047 13.7 1.0 0.1 12.6 1.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 ETS60923.1 - 0.11 12.7 3.1 0.59 10.4 3.1 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 ETS60923.1 - 0.73 9.5 3.0 1.3 8.6 3.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type ATP_bind_1 PF03029.17 ETS60924.1 - 2.3e-84 282.9 0.0 2.7e-84 282.7 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ETS60924.1 - 1.8e-05 24.6 0.0 0.00066 19.5 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_16 PF13191.6 ETS60924.1 - 0.00065 20.1 0.2 0.017 15.5 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AAA_18 PF13238.6 ETS60924.1 - 0.00082 19.9 0.0 0.0018 18.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ETS60924.1 - 0.0013 17.9 0.0 0.0018 17.4 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 ETS60924.1 - 0.0013 18.5 0.0 0.0036 17.1 0.0 1.7 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 ETS60924.1 - 0.0017 18.4 0.0 0.0019 18.2 0.0 1.3 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ETS60924.1 - 0.0021 18.0 0.0 0.37 10.7 0.2 2.3 1 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ETS60924.1 - 0.0036 17.0 0.0 0.0063 16.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ETS60924.1 - 0.005 17.3 0.0 0.068 13.6 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 ETS60924.1 - 0.0059 15.6 0.0 0.0083 15.1 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 ETS60924.1 - 0.008 15.7 0.0 2.3 7.7 0.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 ETS60924.1 - 0.0089 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ETS60924.1 - 0.01 15.2 0.0 0.028 13.8 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_14 PF13173.6 ETS60924.1 - 0.012 15.6 0.0 0.1 12.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETS60924.1 - 0.016 15.5 0.0 0.047 14.0 0.0 2.0 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETS60924.1 - 0.018 15.5 0.0 0.077 13.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 ETS60924.1 - 0.023 14.6 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 ETS60924.1 - 0.029 14.7 0.1 0.53 10.6 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETS60924.1 - 0.034 13.7 0.1 0.37 10.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ETS60924.1 - 0.035 14.2 0.0 0.09 12.9 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_7 PF12775.7 ETS60924.1 - 0.055 13.0 0.0 0.4 10.2 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 ETS60924.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.4 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 ETS60924.1 - 0.08 12.8 0.2 4.5 7.1 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase AAA_33 PF13671.6 ETS60924.1 - 0.093 12.9 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETS60924.1 - 0.1 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ABC_tran PF00005.27 ETS60924.1 - 0.1 13.1 0.0 0.28 11.7 0.0 1.7 2 0 0 2 2 2 0 ABC transporter AAA_10 PF12846.7 ETS60924.1 - 0.13 11.2 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain SRP54 PF00448.22 ETS60924.1 - 0.13 11.9 0.0 0.42 10.2 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Cytidylate_kin PF02224.18 ETS60924.1 - 0.2 11.3 0.1 0.36 10.5 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase CobU PF02283.16 ETS60924.1 - 0.23 11.0 0.1 0.57 9.7 0.1 1.7 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase DUF3841 PF12952.7 ETS60926.1 - 0.2 11.4 0.0 0.34 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3841) 2-Hacid_dh_C PF02826.19 ETS60928.1 - 5.7e-53 178.9 0.0 3e-52 176.6 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETS60928.1 - 7.3e-33 113.1 0.0 1.2e-32 112.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AdoHcyase_NAD PF00670.21 ETS60928.1 - 0.0013 18.9 0.5 0.0032 17.5 0.1 1.8 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_2 PF03446.15 ETS60928.1 - 0.0013 18.9 0.1 0.0042 17.3 0.1 1.9 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Peptidase_C1_2 PF03051.15 ETS60929.1 - 4.6e-144 480.5 0.0 1.3e-143 479.0 0.0 1.6 1 1 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 ETS60929.1 - 0.00027 21.1 0.8 0.23 11.5 0.0 2.7 2 1 0 2 2 2 2 Papain family cysteine protease Glycos_transf_2 PF00535.26 ETS60930.1 - 1.4e-21 77.0 0.0 5.5e-21 75.1 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ETS60930.1 - 4.4e-10 39.8 0.5 1.2e-07 31.9 0.1 2.2 1 1 1 2 2 2 2 Glycosyltransferase like family 2 YAcAr PF10686.9 ETS60930.1 - 0.0019 18.1 0.3 0.0097 15.8 0.1 2.1 2 0 0 2 2 2 1 YspA, cpYpsA-related SLOG family Glyco_tranf_2_4 PF13704.6 ETS60930.1 - 0.039 14.5 0.0 0.13 12.8 0.0 1.9 1 1 1 2 2 2 0 Glycosyl transferase family 2 GNAT_acetyltr_2 PF13718.6 ETS60931.1 - 1.1e-89 299.7 0.0 5.4e-89 297.5 0.0 2.1 2 0 0 2 2 2 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 ETS60931.1 - 2.1e-62 210.1 0.0 3.9e-62 209.2 0.0 1.5 1 0 0 1 1 1 1 Helicase tRNA_bind_2 PF13725.6 ETS60931.1 - 1.5e-59 201.6 7.4 2.7e-55 187.6 0.1 3.3 1 1 1 2 2 2 2 Possible tRNA binding domain DUF1726 PF08351.11 ETS60931.1 - 4.4e-29 100.3 0.0 1.2e-28 98.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_22 PF13401.6 ETS60931.1 - 0.0028 17.9 0.0 0.13 12.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain Acetyltransf_1 PF00583.25 ETS60931.1 - 0.013 15.7 0.0 0.039 14.2 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS60931.1 - 0.041 14.3 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DEAD PF00270.29 ETS60931.1 - 0.13 12.0 0.1 0.37 10.6 0.0 1.7 2 0 0 2 2 2 0 DEAD/DEAH box helicase FAM176 PF14851.6 ETS60931.1 - 3.3 7.4 5.9 9.9 5.8 5.9 1.8 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETS60931.1 - 9.2 5.5 10.2 18 4.6 10.2 1.4 1 0 0 1 1 1 0 NOA36 protein Peptidase_C97 PF05903.14 ETS60932.1 - 1e-21 77.3 0.0 3.6e-15 56.1 0.0 2.1 2 0 0 2 2 2 2 PPPDE putative peptidase domain zf-PARP PF00645.18 ETS60933.1 - 4.5e-23 81.9 0.0 6.5e-23 81.4 0.0 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region AT_hook PF02178.19 ETS60933.1 - 2e-19 67.0 110.3 0.073 13.0 1.9 11.6 11 0 0 11 11 11 11 AT hook motif Mito_carr PF00153.27 ETS60934.1 - 5.4e-61 202.6 6.7 1e-21 76.7 0.1 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 ETS60934.1 - 0.017 14.6 1.9 0.11 12.2 0.1 3.1 4 0 0 4 4 4 0 EF hand EF-hand_6 PF13405.6 ETS60934.1 - 0.019 14.9 0.1 0.08 12.9 0.1 2.2 1 0 0 1 1 1 0 EF-hand domain Pkinase PF00069.25 ETS60935.1 - 1.1e-12 47.9 0.0 1.7e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Seadorna_VP7 PF07387.11 ETS60935.1 - 4.7e-05 22.6 0.0 6.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 ETS60935.1 - 4.9e-05 23.4 2.6 0.00056 19.9 0.2 3.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETS60935.1 - 0.01 15.1 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ETS60935.1 - 0.011 15.1 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETS60935.1 - 0.14 11.8 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Anophelin PF10731.9 ETS60935.1 - 0.32 10.9 2.8 1.2 9.1 0.6 2.8 2 0 0 2 2 2 0 Thrombin inhibitor from mosquito Pkinase_fungal PF17667.1 ETS60935.1 - 0.37 9.5 2.4 0.55 8.9 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase SWIRM-assoc_2 PF16496.5 ETS60935.1 - 5.5 5.8 12.6 9.3 5.0 11.0 2.0 2 0 0 2 2 2 0 SWIRM-associated domain at the N-terminal TMEM214 PF10151.9 ETS60935.1 - 9 4.6 7.6 13 4.1 7.6 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator SRF-TF PF00319.18 ETS60936.1 - 2.7e-20 71.6 0.0 4.3e-20 70.9 0.0 1.4 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) CDC45 PF02724.14 ETS60936.1 - 0.0013 17.1 12.2 0.039 12.2 0.9 2.2 2 0 0 2 2 2 2 CDC45-like protein Sporozoite_P67 PF05642.11 ETS60936.1 - 1.1 7.3 26.4 1.5 6.9 3.9 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen ABC1 PF03109.16 ETS60937.1 - 6.9e-23 81.1 0.0 1.4e-22 80.1 0.0 1.6 1 0 0 1 1 1 1 ABC1 family RIO1 PF01163.22 ETS60937.1 - 0.19 11.3 0.0 0.44 10.1 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Paf67 PF10255.9 ETS60939.1 - 4.6e-169 562.7 0.1 7.5e-169 562.0 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 ETS60939.1 - 0.021 14.9 0.0 0.19 11.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_60s PF00428.19 ETS60939.1 - 0.075 13.6 0.2 0.075 13.6 0.2 4.3 4 1 0 4 4 4 0 60s Acidic ribosomal protein OB_Dis3 PF17849.1 ETS60940.1 - 0.15 12.1 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 Dis3-like cold-shock domain 2 (CSD2) FYVE PF01363.21 ETS60941.1 - 5e-22 77.8 2.3 8.5e-22 77.1 2.3 1.4 1 0 0 1 1 1 1 FYVE zinc finger Rbsn PF11464.8 ETS60941.1 - 3e-13 49.3 0.4 7.5e-13 48.0 0.4 1.8 1 0 0 1 1 1 1 Rabenosyn Rab binding domain THOC7 PF05615.13 ETS60941.1 - 0.71 10.2 3.2 0.32 11.3 0.2 2.0 2 0 0 2 2 2 0 Tho complex subunit 7 ETF_QO PF05187.13 ETS60943.1 - 1e-42 144.5 0.1 1.6e-42 143.8 0.1 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 ETS60943.1 - 3.3e-07 29.8 0.4 1.5e-05 24.3 0.7 2.2 1 1 1 2 2 2 1 FAD binding domain DAO PF01266.24 ETS60943.1 - 2.9e-06 27.1 0.6 0.0002 21.0 0.8 2.5 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS60943.1 - 3.9e-06 27.0 0.0 1.9e-05 24.8 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ETS60943.1 - 2.5e-05 23.2 0.5 3.8e-05 22.6 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 ETS60943.1 - 4.2e-05 22.9 0.0 6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETS60943.1 - 4.4e-05 22.8 0.1 0.00028 20.2 0.3 1.9 2 0 0 2 2 2 1 Thi4 family Pyr_redox_3 PF13738.6 ETS60943.1 - 0.00013 21.3 1.1 0.0002 20.7 1.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS60943.1 - 0.00037 19.6 0.1 0.00059 19.0 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 ETS60943.1 - 0.0024 17.2 0.3 0.0039 16.5 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ETS60943.1 - 0.004 16.5 0.3 0.0064 15.9 0.3 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ETS60943.1 - 0.0066 16.5 0.9 0.013 15.5 0.3 1.7 2 0 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 ETS60943.1 - 0.018 14.2 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 ETS60943.1 - 0.03 13.2 0.7 0.054 12.3 0.7 1.4 1 0 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 ETS60943.1 - 0.032 13.3 0.3 0.048 12.7 0.3 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_7 PF12838.7 ETS60943.1 - 0.041 14.5 1.6 0.086 13.4 1.6 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 ETS60943.1 - 2.4 8.4 5.1 0.25 11.5 0.5 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain Bmt2 PF11968.8 ETS60944.1 - 2.1e-72 243.6 0.0 3e-72 243.1 0.0 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 ETS60944.1 - 0.0013 18.6 0.0 0.0035 17.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DUF2742 PF10888.8 ETS60944.1 - 0.014 15.7 1.4 0.036 14.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2742) MAS20 PF02064.15 ETS60945.1 - 2.5e-39 134.3 0.6 2.5e-39 134.3 0.6 1.9 2 0 0 2 2 2 1 MAS20 protein import receptor GAPT PF11770.8 ETS60945.1 - 0.094 12.6 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) PI3K_1B_p101 PF10486.9 ETS60945.1 - 0.13 10.0 2.3 0.17 9.6 2.3 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RRN3 PF05327.11 ETS60945.1 - 0.32 9.5 2.1 0.43 9.1 2.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GOLD_2 PF13897.6 ETS60945.1 - 0.42 11.1 3.6 19 5.7 0.0 2.7 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking DNA_pol_phi PF04931.13 ETS60945.1 - 4.8 5.2 8.3 8.5 4.3 8.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi UQ_con PF00179.26 ETS60946.1 - 8.1e-51 171.4 0.0 9.4e-51 171.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETS60946.1 - 0.0025 17.5 0.0 0.0035 17.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ETS60946.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.3 1 1 0 1 1 1 0 RWD domain DUF1977 PF09320.11 ETS60947.1 - 3.2e-24 85.2 0.6 5.4e-24 84.5 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 ETS60947.1 - 7.4e-24 83.7 0.1 1.7e-23 82.5 0.1 1.7 1 0 0 1 1 1 1 DnaJ domain CDK2AP PF09806.9 ETS60947.1 - 0.7 9.9 5.2 1.3 9.0 5.2 1.5 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein FAM199X PF15814.5 ETS60947.1 - 5.2 6.0 9.9 8.2 5.4 9.9 1.2 1 0 0 1 1 1 0 Protein family FAM199X CAP PF00188.26 ETS60950.1 - 5.1e-24 85.5 5.8 5.1e-24 85.5 5.8 1.6 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Collagen PF01391.18 ETS60950.1 - 0.0089 15.8 3.5 0.017 14.9 0.6 2.3 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) zf-U1 PF06220.12 ETS60950.1 - 0.11 12.3 2.7 0.3 10.9 2.7 1.7 1 0 0 1 1 1 0 U1 zinc finger Macoilin PF09726.9 ETS60950.1 - 0.87 8.1 7.5 0.93 8.0 7.5 1.0 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 ETS60950.1 - 1.6 7.6 3.5 2 7.3 3.5 1.1 1 0 0 1 1 1 0 Mitoguardin MOZ_SAS PF01853.18 ETS60951.1 - 1.3e-59 200.8 0.0 9e-58 194.9 0.0 2.4 2 0 0 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 ETS60951.1 - 3.7e-14 52.1 2.4 3.9e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 MYST family zinc finger domain Methyltransf_25 PF13649.6 ETS60951.1 - 1e-12 48.6 0.0 8.1e-12 45.7 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS60951.1 - 2e-12 47.6 0.0 8.3e-12 45.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS60951.1 - 1.2e-10 42.0 0.0 7.6e-10 39.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS60951.1 - 1.1e-09 38.3 0.0 3.2e-09 36.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Tudor-knot PF11717.8 ETS60951.1 - 2.4e-09 36.9 0.0 5.1e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF938 PF06080.12 ETS60951.1 - 5e-06 26.4 0.0 1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_31 PF13847.6 ETS60951.1 - 6.6e-05 22.7 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain TPR_12 PF13424.6 ETS60952.1 - 0.0056 16.9 0.2 35 4.8 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETS60952.1 - 0.0069 16.2 0.0 1.6 8.7 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat DeoC PF01791.9 ETS60953.1 - 3.4e-19 69.4 2.0 5.2e-19 68.8 2.0 1.2 1 0 0 1 1 1 1 DeoC/LacD family aldolase His_biosynth PF00977.21 ETS60953.1 - 0.015 14.8 0.2 0.092 12.2 0.1 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein Aminotran_1_2 PF00155.21 ETS60954.1 - 1.5e-39 136.3 0.0 2e-39 135.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3818 PF12825.7 ETS60955.1 - 9.7e-134 445.7 0.0 1.4e-133 445.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 ETS60955.1 - 6.1e-42 142.7 1.5 1.5e-41 141.4 1.5 1.7 1 0 0 1 1 1 1 PX-associated PX PF00787.24 ETS60955.1 - 1.1e-06 28.5 0.0 8.4e-06 25.8 0.0 2.6 1 1 0 1 1 1 1 PX domain TetR_C_26 PF17934.1 ETS60955.1 - 0.015 15.6 0.0 0.032 14.6 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF4611 PF15387.6 ETS60955.1 - 0.086 13.1 2.1 0.67 10.2 2.1 2.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) MRP-L20 PF12824.7 ETS60956.1 - 1.1e-28 100.5 3.9 1.5e-28 100.0 2.6 1.9 2 0 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 Pyr_redox_2 PF07992.14 ETS60956.1 - 4.3e-11 42.6 0.0 1.4e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS60956.1 - 0.02 14.9 0.0 0.22 11.5 0.1 2.1 2 0 0 2 2 2 0 FAD-NAD(P)-binding DAO PF01266.24 ETS60956.1 - 0.022 14.4 0.1 0.034 13.7 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase MCRA PF06100.11 ETS60956.1 - 0.18 10.6 0.1 0.26 10.1 0.1 1.1 1 0 0 1 1 1 0 MCRA family Trypsin_2 PF13365.6 ETS60957.1 - 7.8e-06 26.9 3.6 0.022 15.6 2.3 2.5 1 1 0 2 2 2 2 Trypsin-like peptidase domain Arylesterase PF01731.20 ETS60958.1 - 0.1 12.8 0.0 0.3 11.3 0.0 1.7 1 1 0 1 1 1 0 Arylesterase SBBP PF06739.11 ETS60958.1 - 0.73 9.9 2.6 0.72 9.9 0.5 2.0 2 0 0 2 2 2 0 Beta-propeller repeat DUF3292 PF11696.8 ETS60960.1 - 3.2e-224 746.1 0.0 9.4e-222 738.0 0.0 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3292) ORC5_C PF14630.6 ETS60961.1 - 2.6e-76 256.8 1.1 4.2e-76 256.2 1.1 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus RdRP_4 PF02123.16 ETS60961.1 - 0.16 10.8 0.9 0.42 9.4 0.2 1.8 2 0 0 2 2 2 0 Viral RNA-directed RNA-polymerase DNA_ligase_A_M PF01068.21 ETS60962.1 - 2.9e-06 27.1 0.0 1.5e-05 24.7 0.0 2.2 1 1 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_OB_2 PF14743.6 ETS60962.1 - 3.7e-06 26.9 0.2 9.4e-06 25.6 0.1 1.7 2 0 0 2 2 2 1 DNA ligase OB-like domain DUF1153 PF06627.11 ETS60962.1 - 0.047 13.8 0.0 1.2 9.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1153) EF1_GNE PF00736.19 ETS60963.1 - 3.1e-30 104.2 1.5 3.1e-30 104.2 1.5 1.7 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 ETS60963.1 - 2.5e-13 50.2 3.6 2.5e-13 50.2 3.6 2.4 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Cwf_Cwc_15 PF04889.12 ETS60963.1 - 0.033 13.9 1.9 0.047 13.4 1.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Usp PF00582.26 ETS60964.1 - 5.9e-21 75.4 0.1 8.4e-21 75.0 0.1 1.2 1 0 0 1 1 1 1 Universal stress protein family Toprim_4 PF13662.6 ETS60964.1 - 0.00015 22.2 0.1 0.003 18.0 0.0 2.2 2 0 0 2 2 2 1 Toprim domain Toprim PF01751.22 ETS60964.1 - 0.017 15.4 0.0 0.033 14.4 0.0 1.5 1 0 0 1 1 1 0 Toprim domain DUF3253 PF11625.8 ETS60964.1 - 0.16 12.2 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3253) Ph1570 PF09638.10 ETS60964.1 - 0.16 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Ph1570 protein DUF218 PF02698.17 ETS60965.1 - 6.4e-05 23.0 0.0 0.049 13.7 0.0 2.3 1 1 1 2 2 2 2 DUF218 domain DUF726 PF05277.12 ETS60965.1 - 0.034 13.1 0.1 0.049 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF726) TFIIS_M PF07500.14 ETS60966.1 - 1.3e-23 83.6 0.1 1.9e-23 83.1 0.1 1.2 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain RNA_pol_L_2 PF13656.6 ETS60967.1 - 1.3e-26 92.2 0.0 2.4e-26 91.3 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ETS60967.1 - 9e-08 31.4 0.0 3.9e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain SNF2_N PF00176.23 ETS60968.1 - 1.6e-74 250.7 1.9 3.2e-74 249.8 1.9 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS60968.1 - 7.8e-21 74.5 0.8 3.3e-19 69.3 0.0 3.3 3 1 1 4 4 4 1 Helicase conserved C-terminal domain HSA PF07529.13 ETS60968.1 - 1.5e-20 73.3 7.3 1.5e-20 73.3 7.3 3.5 3 0 0 3 3 3 1 HSA Bromodomain PF00439.25 ETS60968.1 - 4e-15 55.6 0.0 9.9e-15 54.4 0.0 1.7 1 0 0 1 1 1 1 Bromodomain QLQ PF08880.11 ETS60968.1 - 3.8e-14 52.1 1.4 1.1e-13 50.6 1.4 1.8 1 0 0 1 1 1 1 QLQ SnAC PF14619.6 ETS60968.1 - 2.1e-13 50.7 2.4 2.1e-13 50.7 2.4 3.5 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 ETS60968.1 - 9.8e-11 41.9 0.1 5.4e-10 39.5 0.1 2.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ETS60968.1 - 3.1e-05 23.8 0.0 9.9e-05 22.1 0.0 1.8 1 0 0 1 1 1 1 SWI2/SNF2 ATPase RRM_1 PF00076.22 ETS60969.1 - 7.8e-49 163.4 0.0 2.3e-20 72.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS60969.1 - 1.9e-07 30.7 0.0 6.7e-05 22.5 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ETS60969.1 - 0.0023 18.2 0.0 6.2 7.0 0.0 3.8 3 1 1 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter RRM_occluded PF16842.5 ETS60969.1 - 0.04 13.8 0.0 0.85 9.5 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif SET_assoc PF11767.8 ETS60969.1 - 0.1 12.2 0.0 4.6 7.0 0.0 2.3 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated Limkain-b1 PF11608.8 ETS60969.1 - 0.2 11.7 0.0 2.8 8.1 0.0 2.6 3 0 0 3 3 3 0 Limkain b1 DUF2456 PF10445.9 ETS60970.1 - 1e-18 67.2 6.9 1e-18 67.2 6.9 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2456) LrgB PF04172.16 ETS60970.1 - 0.057 12.9 0.5 0.11 12.0 0.5 1.4 1 0 0 1 1 1 0 LrgB-like family Pkinase PF00069.25 ETS60971.1 - 1.5e-63 214.7 0.0 1.7e-63 214.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS60971.1 - 3.9e-19 69.0 0.0 5.4e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETS60971.1 - 3e-07 30.6 0.0 3.5e-06 27.1 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETS60971.1 - 0.013 14.9 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETS60971.1 - 0.013 14.3 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 ETS60971.1 - 0.049 13.2 0.2 0.049 13.2 0.2 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase DOCK_N PF16172.5 ETS60974.1 - 2.6e-112 375.5 0.0 5.8e-112 374.3 0.0 1.6 2 0 0 2 2 2 1 DOCK N-terminus DHR-2 PF06920.13 ETS60974.1 - 3.7e-71 240.4 0.0 7.6e-71 239.3 0.0 1.5 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 ETS60974.1 - 1.7e-51 174.8 0.0 4.7e-51 173.4 0.0 1.8 2 0 0 2 2 2 1 C2 domain in Dock180 and Zizimin proteins tRNA-synt_2d PF01409.20 ETS60975.1 - 5.2e-47 160.4 0.0 6.5e-26 91.3 0.0 2.7 2 1 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 ETS60975.1 - 4.3e-24 84.7 0.1 1e-23 83.5 0.1 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain BORCS7 PF16088.5 ETS60976.1 - 0.025 14.8 0.3 0.025 14.8 0.3 1.8 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DUF1664 PF07889.12 ETS60976.1 - 0.053 13.6 0.0 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PRKG1_interact PF15898.5 ETS60976.1 - 0.52 11.2 4.2 0.82 10.6 0.4 2.6 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain PAP_assoc PF03828.19 ETS60977.1 - 5.1e-21 74.6 0.0 1.3e-20 73.4 0.0 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETS60977.1 - 6.8e-10 39.1 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain DEAD PF00270.29 ETS60978.1 - 1.3e-51 174.9 0.0 2e-50 171.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS60978.1 - 2.5e-27 95.4 0.0 3.2e-26 91.8 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS60978.1 - 0.0025 17.8 0.0 0.011 15.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit KTI12 PF08433.10 ETS60979.1 - 3.1e-60 203.9 0.0 5e-60 203.3 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ETS60979.1 - 2e-06 28.0 0.0 4.6e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain FAD_binding_2 PF00890.24 ETS60980.1 - 2.1e-126 422.4 3.1 2.7e-126 422.0 3.1 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ETS60980.1 - 1.9e-44 150.8 0.7 2.9e-44 150.2 0.7 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 ETS60980.1 - 1.4e-05 24.4 1.1 0.037 13.1 1.9 2.4 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 ETS60980.1 - 5.5e-05 22.5 0.5 0.012 14.9 0.1 2.4 2 0 0 2 2 2 2 Thi4 family FAD_binding_3 PF01494.19 ETS60980.1 - 0.0054 16.0 0.2 0.011 15.0 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS60980.1 - 0.0076 15.5 1.0 0.022 14.0 0.3 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS60980.1 - 0.03 13.9 1.4 0.2 11.2 1.4 2.2 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 ETS60980.1 - 0.19 10.4 2.6 0.7 8.5 0.5 2.7 3 0 0 3 3 3 0 HI0933-like protein Sec7 PF01369.20 ETS60981.1 - 3.2e-64 216.0 0.0 5.6e-64 215.2 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ETS60981.1 - 1.4e-17 64.1 0.0 1.1e-16 61.2 0.0 2.6 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF913 PF06025.12 ETS60981.1 - 0.01 14.8 0.1 0.024 13.6 0.1 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Spt20 PF12090.8 ETS60981.1 - 1.1 8.8 5.5 0.13 11.8 0.3 2.0 2 0 0 2 2 2 0 Spt20 family AAR2 PF05282.11 ETS60982.1 - 2.2e-76 257.6 0.0 2.5e-76 257.4 0.0 1.0 1 0 0 1 1 1 1 AAR2 protein DUF1188 PF06690.11 ETS60984.1 - 0.12 11.9 0.4 0.25 10.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) Cellulase PF00150.18 ETS60985.1 - 5.7e-14 52.2 17.0 1.7e-13 50.7 17.0 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ATG_C PF09333.11 ETS60986.1 - 4.7e-27 94.2 0.3 1.5e-26 92.5 0.3 2.0 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain ATG2_CAD PF13329.6 ETS60986.1 - 3.6e-17 62.5 0.0 8.1e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif Chorein_N PF12624.7 ETS60986.1 - 9.2e-14 51.6 0.0 3.8e-13 49.6 0.0 2.0 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 VPS13_C PF16909.5 ETS60986.1 - 0.0077 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal RabGAP-TBC PF00566.18 ETS60987.1 - 1.5e-25 90.2 0.0 1.5e-20 73.8 0.0 2.9 2 1 0 2 2 2 2 Rab-GTPase-TBC domain CDC50 PF03381.15 ETS60988.1 - 3.9e-91 305.4 0.2 4.9e-91 305.1 0.2 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family SnoaL PF07366.12 ETS60989.1 - 9.5e-07 28.7 0.0 1.8e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 ETS60989.1 - 5.3e-05 23.8 0.1 0.00023 21.8 0.0 2.2 2 1 1 3 3 3 1 SnoaL-like domain Peptidase_S66 PF02016.15 ETS60989.1 - 0.03 14.5 0.0 0.077 13.1 0.0 1.7 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain AMP-binding PF00501.28 ETS60990.1 - 7.9e-91 304.8 0.0 1.2e-90 304.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS60990.1 - 4.7e-14 53.1 1.4 4.7e-14 53.1 1.4 1.9 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RhoGAP PF00620.27 ETS60991.1 - 7.1e-39 133.1 0.0 1.4e-38 132.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain RasGEF PF00617.19 ETS60991.1 - 4.4e-12 46.6 0.0 1.7e-11 44.7 0.0 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ETS60991.1 - 4.2e-11 43.0 0.0 2.7e-10 40.4 0.0 2.4 2 1 0 2 2 2 1 RasGEF N-terminal motif PH PF00169.29 ETS60991.1 - 4.2e-07 30.4 0.0 0.0037 17.7 0.0 2.7 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 ETS60991.1 - 7.7e-07 29.5 0.0 2.2e-05 24.8 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain Trypan_PARP PF05887.11 ETS60991.1 - 4.4e-05 23.5 10.7 4.4e-05 23.5 10.7 2.3 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) SPESP1 PF15754.5 ETS60991.1 - 0.5 9.5 6.0 1.1 8.3 6.0 1.5 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Sld5 PF05916.11 ETS60992.1 - 1e-19 71.0 0.0 1.7e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein SNARE_assoc PF09335.11 ETS60993.1 - 3.7e-09 37.1 5.4 3.7e-09 37.1 5.4 3.0 3 1 0 3 3 3 1 SNARE associated Golgi protein MacB_PCD PF12704.7 ETS60993.1 - 0.00088 19.7 0.0 0.39 11.0 0.0 2.5 2 0 0 2 2 2 2 MacB-like periplasmic core domain CPP1-like PF11833.8 ETS60993.1 - 0.28 10.8 4.0 1.6 8.3 0.1 3.0 2 1 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Sugar_tr PF00083.24 ETS60994.1 - 1.4e-99 334.0 15.2 2.4e-56 191.5 3.4 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETS60994.1 - 4.8e-26 91.5 29.3 1e-25 90.5 18.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ETS60994.1 - 0.00015 20.3 3.2 0.00028 19.5 3.2 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Phage_holin_3_2 PF04550.12 ETS60994.1 - 0.064 13.8 8.9 0.033 14.7 5.3 2.5 2 0 0 2 2 2 0 Phage holin family 2 SRP68 PF16969.5 ETS60996.1 - 1e-53 183.2 48.0 4.3e-47 161.4 30.6 3.2 2 1 0 2 2 2 2 RNA-binding signal recognition particle 68 DIOX_N PF14226.6 ETS60997.1 - 8.8e-21 74.9 0.0 1.6e-20 74.0 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETS60997.1 - 2e-18 66.7 0.0 5.3e-18 65.4 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Glyco_transf_15 PF01793.16 ETS60999.1 - 9e-117 389.9 3.2 1.1e-116 389.6 3.2 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase WD40 PF00400.32 ETS61001.1 - 9e-38 127.6 22.3 0.0076 17.1 0.0 11.8 11 0 0 11 11 11 10 WD domain, G-beta repeat Utp12 PF04003.12 ETS61001.1 - 9.1e-20 71.0 0.5 1.8e-19 70.0 0.5 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 ETS61001.1 - 5.1e-19 68.4 0.9 0.00038 20.7 0.0 7.3 6 3 3 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS61001.1 - 1.7e-08 33.6 0.9 0.027 13.1 0.0 5.7 5 2 1 6 6 6 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETS61001.1 - 2.1e-06 26.9 0.2 1.3 7.9 0.0 5.3 7 0 0 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Utp21 PF04192.12 ETS61001.1 - 0.032 13.7 1.3 0.09 12.3 0.1 2.0 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain PALB2_WD40 PF16756.5 ETS61001.1 - 0.037 13.0 1.8 4.2 6.2 0.2 2.8 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Rtf2 PF04641.12 ETS61001.1 - 0.084 12.2 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger PQQ_3 PF13570.6 ETS61001.1 - 0.39 11.3 1.9 6.6 7.4 0.0 3.7 3 0 0 3 3 3 0 PQQ-like domain Maf PF02545.14 ETS61002.1 - 3.3e-44 150.7 0.0 3.8e-44 150.5 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein COX7a PF02238.15 ETS61003.1 - 9e-19 67.6 0.5 1.2e-18 67.2 0.5 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII TrmO_C PF18389.1 ETS61003.1 - 0.037 14.1 0.0 0.051 13.7 0.0 1.3 1 0 0 1 1 1 0 TrmO C-terminal domain Glyoxal_oxid_N PF07250.11 ETS61005.1 - 9.9e-29 100.2 2.9 3.2e-26 92.0 1.5 3.7 3 1 0 3 3 3 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ETS61005.1 - 1.4e-21 76.6 0.1 2.8e-21 75.6 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Reg_prop PF07494.11 ETS61005.1 - 0.13 12.6 1.0 26 5.5 0.0 2.9 2 0 0 2 2 2 0 Two component regulator propeller Kelch_4 PF13418.6 ETS61005.1 - 0.13 12.3 4.1 10 6.2 0.1 4.6 5 0 0 5 5 5 0 Galactose oxidase, central domain Arm PF00514.23 ETS61006.1 - 6.3e-66 216.6 26.0 4.6e-11 42.4 0.1 11.6 11 0 0 11 11 11 9 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETS61006.1 - 4.9e-12 46.1 18.2 0.0013 19.1 0.4 8.5 7 3 2 9 9 8 5 HEAT-like repeat HEAT_2 PF13646.6 ETS61006.1 - 3e-11 43.5 9.9 0.0025 18.2 0.0 7.0 3 2 3 6 6 6 3 HEAT repeats Adaptin_N PF01602.20 ETS61006.1 - 7.4e-09 34.7 6.0 9.8e-07 27.7 0.2 2.8 1 1 1 2 2 2 2 Adaptin N terminal region KAP PF05804.12 ETS61006.1 - 1.1e-08 33.7 0.2 1.8e-08 33.1 0.2 1.1 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Arm_2 PF04826.13 ETS61006.1 - 3.3e-08 33.3 5.0 2.4e-05 23.9 1.2 2.3 2 0 0 2 2 2 2 Armadillo-like HEAT PF02985.22 ETS61006.1 - 5.5e-08 32.4 13.0 4 8.0 0.0 9.2 10 0 0 10 10 9 2 HEAT repeat V-ATPase_H_N PF03224.14 ETS61006.1 - 9.6e-06 25.1 4.3 0.021 14.1 0.4 3.7 1 1 2 3 3 3 3 V-ATPase subunit H DUF3361 PF11841.8 ETS61006.1 - 0.00019 21.4 1.4 0.63 10.0 0.1 3.7 3 1 0 4 4 4 1 Domain of unknown function (DUF3361) Sigma70_r3 PF04539.16 ETS61006.1 - 0.0017 18.4 0.0 0.06 13.4 0.0 3.1 2 0 0 2 2 2 1 Sigma-70 region 3 Cnd1 PF12717.7 ETS61006.1 - 0.006 16.6 3.4 0.77 9.8 0.1 3.5 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 FeoC PF09012.10 ETS61006.1 - 0.92 9.6 4.8 0.88 9.7 0.0 2.6 2 0 0 2 2 2 0 FeoC like transcriptional regulator COX6A PF02046.15 ETS61007.1 - 1.8e-36 125.0 1.5 2.2e-36 124.8 1.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Velvet PF11754.8 ETS61008.1 - 1.6e-67 228.1 0.0 3.6e-67 226.9 0.0 1.6 2 0 0 2 2 2 1 Velvet factor UPF0086 PF01868.16 ETS61009.1 - 2.4e-22 78.6 0.0 3.7e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Polysacc_deac_1 PF01522.21 ETS61011.1 - 4.2e-21 75.1 0.0 1.3e-20 73.5 0.0 1.8 1 0 0 1 1 1 1 Polysaccharide deacetylase PAP1 PF08601.10 ETS61011.1 - 2.5 7.7 12.7 3.7 7.2 12.7 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 MRP-S25 PF13741.6 ETS61012.1 - 1.2e-63 214.7 0.2 1.2e-63 214.7 0.2 1.5 2 0 0 2 2 2 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 ETS61012.1 - 6.3e-07 29.7 0.4 0.032 14.5 0.2 2.6 2 0 0 2 2 2 2 Mitochondrial ribosomal protein S23 FH2 PF02181.23 ETS61013.1 - 7.9e-86 288.5 0.0 7.9e-86 288.5 0.0 2.7 2 1 1 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ETS61013.1 - 1.2e-29 103.2 0.1 6.9e-21 74.7 0.0 3.6 3 0 0 3 3 3 2 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ETS61013.1 - 1.6e-20 73.5 0.9 4.4e-20 72.1 0.9 1.8 1 0 0 1 1 1 1 Diaphanous FH3 Domain Erp_C PF06780.11 ETS61013.1 - 0.045 13.8 1.9 0.26 11.3 0.0 2.9 2 1 1 3 3 3 0 Erp protein C-terminus Pyr_redox_2 PF07992.14 ETS61014.1 - 1.2e-69 234.8 0.8 1.8e-69 234.2 0.5 1.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETS61014.1 - 2.1e-28 98.8 1.3 4.4e-28 97.7 1.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ETS61014.1 - 2.1e-22 79.5 3.7 6.3e-19 68.3 0.0 2.8 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS61014.1 - 9.8e-14 51.3 0.0 2.3e-11 43.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS61014.1 - 9e-06 24.6 4.0 0.1 11.3 0.0 3.2 2 1 0 3 3 3 2 HI0933-like protein FAD_oxidored PF12831.7 ETS61014.1 - 1.5e-05 24.6 0.0 3.2e-05 23.5 0.1 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ETS61014.1 - 0.00046 19.4 0.1 0.0034 16.6 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ETS61014.1 - 0.0067 16.6 0.7 0.021 15.0 0.7 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 ETS61014.1 - 0.032 14.7 0.1 9 6.8 0.0 2.6 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 ETS61014.1 - 0.07 12.2 4.0 0.11 11.6 2.8 1.9 2 0 0 2 2 2 0 FAD binding domain DUF576 PF04507.12 ETS61014.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Csa1 family FtsJ PF01728.19 ETS61015.1 - 1e-42 146.2 0.0 1.5e-42 145.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF2849 PF11011.8 ETS61015.1 - 0.84 10.3 3.3 1.7 9.4 0.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2849) Porphobil_deam PF01379.20 ETS61016.1 - 2.8e-66 222.9 0.0 1.1e-61 207.9 0.0 2.4 2 0 0 2 2 2 2 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ETS61016.1 - 1.9e-15 57.0 0.0 5.4e-09 36.3 0.0 2.6 2 0 0 2 2 2 2 Porphobilinogen deaminase, C-terminal domain DUF848 PF05852.11 ETS61016.1 - 0.15 12.2 0.0 0.15 12.2 0.0 2.6 3 0 0 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) RNA_pol_Rpb2_6 PF00562.28 ETS61017.1 - 3.3e-113 378.7 0.0 7.4e-113 377.5 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ETS61017.1 - 5.4e-29 101.2 0.0 8.6e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ETS61017.1 - 1.8e-26 92.1 0.0 4.1e-26 90.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 ETS61017.1 - 1.9e-23 82.2 0.0 9.1e-23 80.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_2 PF04561.14 ETS61017.1 - 3.8e-19 69.1 0.0 6.3e-19 68.3 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 ETS61017.1 - 5.9e-18 65.0 0.2 7.7e-15 55.1 0.1 2.5 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 7 FAD_binding_7 PF03441.14 ETS61020.1 - 6.2e-51 172.8 1.2 1e-50 172.0 1.2 1.3 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 ETS61020.1 - 5.5e-23 81.8 0.0 1.2e-22 80.7 0.0 1.5 1 1 0 1 1 1 1 DNA photolyase 7TMR-DISMED2 PF07696.11 ETS61020.1 - 0.037 14.1 0.4 3.8 7.6 0.1 2.5 1 1 1 2 2 2 0 7TMR-DISM extracellular 2 Tyrosinase PF00264.20 ETS61021.1 - 5.6e-17 62.8 1.6 1e-16 61.9 1.6 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase YEATS PF03366.16 ETS61022.1 - 1.7e-40 136.9 0.0 2.5e-40 136.3 0.0 1.3 1 0 0 1 1 1 1 YEATS family PRCC PF10253.9 ETS61022.1 - 0.96 10.2 8.7 0.56 11.0 3.0 2.3 2 1 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting PPR_2 PF13041.6 ETS61023.1 - 2.6e-41 139.6 0.0 1.8e-12 47.2 0.0 8.1 8 1 1 9 9 9 4 PPR repeat family PPR PF01535.20 ETS61023.1 - 2.3e-32 108.9 0.8 0.00027 21.0 0.0 12.1 12 0 0 12 12 12 6 PPR repeat PPR_3 PF13812.6 ETS61023.1 - 2.1e-31 107.8 0.0 2.7e-09 36.9 0.0 6.9 5 1 2 7 7 7 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETS61023.1 - 4.4e-26 90.3 0.0 0.0017 18.0 0.0 7.9 8 0 0 8 8 8 5 PPR repeat PPR_long PF17177.4 ETS61023.1 - 4.8e-14 52.2 0.8 1.7e-11 43.9 0.1 4.1 3 2 1 4 4 4 1 Pentacotripeptide-repeat region of PRORP TPR_2 PF07719.17 ETS61023.1 - 0.00065 19.6 1.7 0.87 9.9 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETS61023.1 - 0.14 12.3 0.3 12 6.0 0.0 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MBOAT_2 PF13813.6 ETS61025.1 - 3.2e-06 27.3 4.7 3.3e-06 27.3 0.5 2.8 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Ribosomal_L14 PF00238.19 ETS61026.1 - 1.2e-45 154.5 1.6 1.4e-45 154.3 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e IKI3 PF04762.12 ETS61027.1 - 7.6e-277 921.1 0.0 1e-276 920.7 0.0 1.2 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 ETS61027.1 - 0.002 18.4 0.4 2.3 8.6 0.2 5.0 5 1 0 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Antimicrobial_1 PF08018.11 ETS61027.1 - 0.02 15.1 0.1 0.091 12.9 0.1 2.3 1 0 0 1 1 1 0 Frog antimicrobial peptide Se-cys_synth_N PF12390.8 ETS61027.1 - 0.05 13.8 2.2 0.14 12.4 0.1 2.8 2 0 0 2 2 2 0 Selenocysteine synthase N terminal AAA_11 PF13086.6 ETS61028.1 - 3.4e-72 243.4 0.3 6.3e-72 242.5 0.3 1.4 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ETS61028.1 - 6.1e-51 172.9 0.0 9.8e-51 172.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS61028.1 - 8.9e-14 51.6 3.8 2e-12 47.2 1.2 2.8 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ETS61028.1 - 1.5e-09 38.0 0.1 0.055 13.2 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 ETS61028.1 - 2.7e-08 34.3 0.0 6.9e-08 32.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ETS61028.1 - 9.8e-05 22.0 0.0 0.0022 17.5 0.0 2.0 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_16 PF13191.6 ETS61028.1 - 0.0001 22.7 1.8 0.00083 19.8 1.7 2.4 1 1 0 1 1 1 1 AAA ATPase domain UvrD_C_2 PF13538.6 ETS61028.1 - 0.00016 21.4 0.1 0.00059 19.6 0.0 2.0 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 ETS61028.1 - 0.00018 20.9 1.0 0.025 13.8 0.1 2.9 2 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.6 ETS61028.1 - 0.00028 20.5 0.3 0.001 18.7 0.3 1.9 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETS61028.1 - 0.00054 20.3 0.1 0.0056 17.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 ETS61028.1 - 0.0006 19.3 0.0 0.98 8.8 0.0 2.7 3 0 0 3 3 3 2 PhoH-like protein DEAD PF00270.29 ETS61028.1 - 0.0011 18.7 0.1 0.0096 15.7 0.1 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 ETS61028.1 - 0.007 15.5 0.0 0.013 14.5 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA PF00004.29 ETS61028.1 - 0.012 16.0 1.3 0.035 14.5 0.4 2.3 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETS61028.1 - 0.021 14.6 0.0 0.062 13.0 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain ResIII PF04851.15 ETS61028.1 - 0.06 13.4 0.0 0.94 9.5 0.0 2.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 ETS61028.1 - 0.06 13.2 0.2 1.4 8.7 0.0 2.5 1 1 0 2 2 2 0 Helicase Mg_chelatase PF01078.21 ETS61028.1 - 0.11 11.8 0.1 0.25 10.7 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Herpes_ori_bp PF02399.15 ETS61028.1 - 0.23 9.5 0.0 0.36 8.8 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein FGF-BP1 PF06473.12 ETS61028.1 - 3.2 7.5 4.6 0.48 10.2 0.2 1.8 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) MitMem_reg PF13012.6 ETS61029.1 - 5.9e-36 123.3 0.2 9.4e-36 122.6 0.2 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ETS61029.1 - 1.7e-31 108.7 0.0 2.9e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PLDc_2 PF13091.6 ETS61030.1 - 9e-16 58.0 0.0 3.3e-08 33.5 0.0 2.2 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ETS61030.1 - 7.2e-08 32.3 1.9 0.0073 16.5 0.2 2.9 2 1 0 2 2 2 2 Phospholipase D Active site motif IGPD PF00475.18 ETS61031.1 - 1.5e-59 200.4 0.3 3.6e-59 199.2 0.3 1.7 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase CoA_transf_3 PF02515.17 ETS61032.1 - 1.3e-33 116.7 0.7 1.6e-31 109.8 0.4 2.6 1 1 1 2 2 2 2 CoA-transferase family III FAM72 PF14976.6 ETS61036.1 - 1.6e-16 60.8 7.3 3.8e-16 59.5 6.3 2.1 2 1 0 2 2 2 1 FAM72 protein Yippee-Mis18 PF03226.14 ETS61036.1 - 0.098 12.9 4.3 7.2 6.9 1.2 2.4 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly UreF PF01730.16 ETS61039.1 - 1.1e-18 68.1 0.7 3.1e-18 66.6 0.6 1.7 1 1 0 1 1 1 1 UreF PEP_mutase PF13714.6 ETS61040.1 - 1.1e-36 126.5 0.9 1.3e-36 126.3 0.9 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 ETS61040.1 - 7e-15 54.5 0.2 9.4e-15 54.1 0.2 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PBP1_TM PF14812.6 ETS61041.1 - 0.0012 19.1 6.6 0.085 13.2 0.5 3.0 3 0 0 3 3 3 2 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 ETS61041.1 - 3.7 8.0 7.9 0.52 10.7 1.6 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ETS61041.1 - 4 7.1 11.3 11 5.6 0.3 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PI3_PI4_kinase PF00454.27 ETS61042.1 - 2.9e-53 181.2 0.0 6.6e-53 180.1 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ETS61042.1 - 3.5e-24 85.7 0.1 7.2e-24 84.6 0.1 1.5 1 0 0 1 1 1 1 FAT domain UME PF08064.13 ETS61042.1 - 9.1e-24 83.3 0.0 1.3e-22 79.7 0.0 2.9 2 0 0 2 2 2 1 UME (NUC010) domain FATC PF02260.20 ETS61042.1 - 5.8e-11 42.0 0.8 1.4e-10 40.8 0.1 2.1 2 0 0 2 2 2 1 FATC domain DUF3385 PF11865.8 ETS61042.1 - 0.0088 16.0 0.0 0.035 14.0 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) TPR_19 PF14559.6 ETS61042.1 - 0.42 11.2 2.2 1.4 9.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_8 PF01501.20 ETS61043.1 - 1.5e-16 60.8 0.0 1.7e-14 54.0 0.0 2.6 2 1 0 2 2 2 2 Glycosyl transferase family 8 Ysc84 PF04366.12 ETS61044.1 - 1e-41 141.7 0.6 2.4e-41 140.5 0.1 1.8 2 0 0 2 2 2 1 Las17-binding protein actin regulator Sec3_C PF09763.9 ETS61045.1 - 4.5e-195 650.1 0.0 5.8e-195 649.7 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 ETS61045.1 - 2.5e-23 82.0 0.2 4.7e-23 81.1 0.2 1.5 1 0 0 1 1 1 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 ETS61045.1 - 2e-05 23.5 0.7 2e-05 23.5 0.7 1.5 2 0 0 2 2 2 1 Vps52 / Sac2 family PPR_2 PF13041.6 ETS61046.1 - 6.3e-22 77.5 0.0 2.1e-06 27.8 0.0 6.3 5 1 1 6 6 6 4 PPR repeat family PPR PF01535.20 ETS61046.1 - 1.5e-14 53.1 2.0 0.0025 17.9 0.0 6.6 7 1 0 7 7 7 2 PPR repeat PPR_3 PF13812.6 ETS61046.1 - 4.6e-10 39.4 0.0 0.0085 16.1 0.0 3.6 3 0 0 3 3 3 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETS61046.1 - 2.4e-07 30.3 1.2 0.0046 16.6 0.0 5.7 6 1 0 6 6 6 1 PPR repeat PPR_long PF17177.4 ETS61046.1 - 1e-05 25.0 0.5 0.059 12.7 0.0 3.1 2 1 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP ABC_membrane_2 PF06472.15 ETS61047.1 - 1.7e-94 316.2 1.3 2.4e-94 315.7 1.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ETS61047.1 - 3.1e-19 69.9 0.0 5.9e-19 68.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETS61047.1 - 4.7e-05 23.4 0.0 0.00013 21.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ETS61047.1 - 0.0019 18.8 0.2 0.03 14.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ETS61047.1 - 0.027 13.9 0.0 0.18 11.2 0.0 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS61047.1 - 0.036 13.8 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.15 ETS61047.1 - 0.043 12.6 0.0 0.074 11.8 0.0 1.3 1 0 0 1 1 1 0 Adenovirus IVa2 protein Rad17 PF03215.15 ETS61047.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_15 PF13175.6 ETS61047.1 - 0.22 11.2 0.0 0.46 10.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain TFA2_Winged_2 PF18121.1 ETS61048.1 - 6.3e-18 64.2 0.0 1.6e-17 62.9 0.0 1.7 2 0 0 2 2 2 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 ETS61048.1 - 1.6e-07 31.5 0.0 3.9e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain ATP-synt_DE_N PF02823.16 ETS61049.1 - 1.8e-13 50.2 0.2 2.8e-13 49.6 0.2 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Prefoldin PF02996.17 ETS61050.1 - 4e-26 91.3 1.8 8e-26 90.3 1.8 1.5 1 0 0 1 1 1 1 Prefoldin subunit Baculo_PEP_C PF04513.12 ETS61050.1 - 0.49 10.4 3.2 3.9 7.5 0.2 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus SlyX PF04102.12 ETS61050.1 - 1 10.0 4.3 1.8 9.2 1.7 2.8 2 0 0 2 2 2 0 SlyX CSRNP_N PF16019.5 ETS61051.1 - 0.14 12.1 1.6 0.15 11.9 1.6 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus SR-25 PF10500.9 ETS61051.1 - 0.39 10.3 14.1 0.52 9.9 14.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Hc1 PF07432.13 ETS61051.1 - 1.2 9.5 10.7 1.7 9.0 10.7 1.2 1 0 0 1 1 1 0 Histone H1-like protein Hc1 Nucleo_P87 PF07267.11 ETS61051.1 - 1.5 7.6 8.9 1.8 7.4 8.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 3HCDH_N PF02737.18 ETS61052.1 - 1.3e-52 178.3 1.8 2.2e-52 177.6 1.8 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ETS61052.1 - 9.7e-31 106.3 0.0 2.2e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.23 ETS61052.1 - 0.00063 19.7 0.2 0.0015 18.5 0.2 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 ETS61052.1 - 0.0017 18.0 0.7 0.0034 17.0 0.7 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Sacchrp_dh_NADP PF03435.18 ETS61052.1 - 0.0077 16.5 2.5 0.047 13.9 2.4 2.3 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 ETS61052.1 - 0.021 15.0 3.6 0.17 12.1 2.5 2.5 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase DUF1188 PF06690.11 ETS61052.1 - 0.025 14.1 0.1 0.037 13.6 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1188) Shikimate_DH PF01488.20 ETS61052.1 - 0.068 13.2 0.6 0.22 11.6 0.3 2.0 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ETS61052.1 - 0.17 12.5 4.1 3.7 8.2 4.1 2.6 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 ETS61052.1 - 0.26 11.4 4.1 2.4 8.3 2.5 2.8 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus HA2 PF04408.23 ETS61053.1 - 2.5e-26 92.1 0.0 5.2e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETS61053.1 - 3.6e-18 65.7 0.1 1.3e-17 63.9 0.0 2.1 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ETS61053.1 - 1.1e-10 41.8 0.0 2.7e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS61053.1 - 4.7e-08 33.0 0.1 1e-07 31.9 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETS61053.1 - 3.4e-06 27.4 0.0 8.3e-06 26.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETS61053.1 - 4.3e-05 23.9 0.2 9.7e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ETS61053.1 - 0.0019 18.2 0.0 0.0069 16.4 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETS61053.1 - 0.0035 17.1 0.0 0.0068 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ETS61053.1 - 0.0099 15.2 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Flavi_DEAD PF07652.14 ETS61053.1 - 0.01 15.8 0.5 0.029 14.4 0.5 1.8 1 1 0 1 1 1 0 Flavivirus DEAD domain SRP54 PF00448.22 ETS61053.1 - 0.031 13.9 0.5 0.17 11.5 0.5 2.1 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 ETS61053.1 - 0.078 13.0 0.6 4.1 7.4 0.1 2.6 3 0 0 3 3 3 0 AAA domain Myosin_head PF00063.21 ETS61053.1 - 0.086 11.0 0.0 0.16 10.2 0.0 1.3 1 0 0 1 1 1 0 Myosin head (motor domain) PhoH PF02562.16 ETS61053.1 - 0.093 12.2 0.0 0.61 9.5 0.0 2.3 3 0 0 3 3 3 0 PhoH-like protein ABC_tran PF00005.27 ETS61053.1 - 0.17 12.4 0.0 0.59 10.7 0.0 1.8 1 0 0 1 1 1 0 ABC transporter VWA PF00092.28 ETS61054.1 - 8.8e-12 45.6 0.0 1.9e-11 44.5 0.0 1.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETS61054.1 - 1.3e-07 32.3 0.0 2.6e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain Med25_VWA PF11265.8 ETS61054.1 - 0.0063 16.4 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A Troponin PF00992.20 ETS61054.1 - 0.0074 16.6 0.2 0.012 15.9 0.2 1.2 1 0 0 1 1 1 1 Troponin Integrin_beta PF00362.18 ETS61054.1 - 0.12 12.0 0.0 1.5 8.5 0.0 2.1 1 1 1 2 2 2 0 Integrin beta chain VWA domain Arv1 PF04161.13 ETS61055.1 - 5.6e-18 65.9 0.0 2.2e-17 63.9 0.0 1.8 1 1 0 1 1 1 1 Arv1-like family Tom22 PF04281.13 ETS61056.1 - 3.6e-45 153.1 1.4 4.4e-45 152.9 1.4 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Pes-10 PF07149.11 ETS61056.1 - 0.23 10.5 6.2 0.34 9.9 6.2 1.2 1 0 0 1 1 1 0 Pes-10 FAM176 PF14851.6 ETS61056.1 - 0.69 9.6 4.4 0.73 9.5 3.4 1.5 2 0 0 2 2 2 0 FAM176 family RRN3 PF05327.11 ETS61056.1 - 1.6 7.2 3.4 1.9 6.9 3.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pho88 PF10032.9 ETS61057.1 - 2.6e-73 245.2 0.0 2.9e-73 245.0 0.0 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) CK_II_beta PF01214.18 ETS61058.1 - 1.1e-75 253.5 0.0 1.3e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Fcf2 PF08698.11 ETS61059.1 - 2.8e-23 82.1 0.5 1.8e-20 73.2 0.2 3.1 2 0 0 2 2 2 2 Fcf2 pre-rRNA processing Sas10 PF09368.10 ETS61060.1 - 4.9e-27 94.2 4.2 4.9e-27 94.2 4.2 3.0 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 ETS61060.1 - 1.1e-07 32.4 0.1 4.9e-07 30.3 0.1 2.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Thiolase_N PF00108.23 ETS61061.1 - 6e-74 248.7 0.4 1.7e-73 247.2 0.1 1.8 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETS61061.1 - 2.2e-45 153.3 0.4 4e-45 152.4 0.4 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 ETS61061.1 - 0.00011 22.4 0.0 0.00029 20.9 0.0 1.8 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 ETS61061.1 - 0.0014 18.2 2.6 0.0016 18.1 0.1 2.4 4 0 0 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ETS61061.1 - 0.02 14.8 2.3 0.23 11.4 0.1 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III BRCA-2_helical PF09169.10 ETS61061.1 - 0.057 13.1 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 BRCA2, helical DUF2093 PF09866.9 ETS61061.1 - 0.15 11.6 0.0 0.37 10.3 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2093) DIOX_N PF14226.6 ETS61062.1 - 0.0013 19.4 0.2 0.0042 17.8 0.2 1.9 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal Ubie_methyltran PF01209.18 ETS61063.1 - 3.6e-73 245.7 0.2 3.5e-38 131.2 0.0 2.6 3 0 0 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ETS61063.1 - 1.7e-13 51.1 0.0 1.5e-07 32.0 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ETS61063.1 - 3.5e-12 46.9 0.0 5.7e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS61063.1 - 1e-10 42.1 0.0 9.2e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ETS61063.1 - 2.2e-09 37.3 0.0 1.2e-08 34.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS61063.1 - 1.6e-07 31.3 0.0 2.8e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ETS61063.1 - 0.0035 17.2 0.0 0.016 15.0 0.0 2.1 3 0 0 3 3 3 1 Hypothetical methyltransferase Methyltransf_28 PF02636.17 ETS61063.1 - 0.059 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Cullin PF00888.22 ETS61064.1 - 2.6e-179 597.8 3.8 3.3e-179 597.4 3.8 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ETS61064.1 - 9e-27 92.9 4.4 2e-26 91.8 1.5 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain GntR PF00392.21 ETS61064.1 - 0.013 15.1 0.0 0.3 10.8 0.1 2.5 2 0 0 2 2 2 0 Bacterial regulatory proteins, gntR family Penicillinase_R PF03965.16 ETS61064.1 - 0.029 14.7 9.7 3.2 8.1 0.1 5.2 4 2 1 5 5 5 0 Penicillinase repressor Lipase_GDSL_2 PF13472.6 ETS61064.1 - 0.084 13.3 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Phage_rep_O PF04492.13 ETS61064.1 - 0.11 13.1 0.4 0.37 11.4 0.1 2.1 2 0 0 2 2 2 0 Bacteriophage replication protein O AnfG_VnfG PF03139.15 ETS61064.1 - 0.29 11.2 3.3 0.21 11.7 0.2 2.4 3 0 0 3 3 3 0 Vanadium/alternative nitrogenase delta subunit DUF4404 PF14357.6 ETS61064.1 - 0.51 11.0 4.3 2.1 9.1 0.7 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) AAA_23 PF13476.6 ETS61066.1 - 1.4e-33 117.1 0.6 1.4e-33 117.1 0.6 8.6 1 1 2 4 4 4 1 AAA domain AAA_15 PF13175.6 ETS61066.1 - 7.5e-13 48.9 18.2 1.6e-10 41.3 0.4 5.0 1 1 1 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 ETS61066.1 - 5.6e-12 46.1 2.5 1.1e-05 25.4 0.0 3.4 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETS61066.1 - 1.8e-09 37.4 28.8 4e-07 29.7 0.0 3.1 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETS61066.1 - 4.4e-06 26.8 0.0 1.4e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_13 PF13166.6 ETS61066.1 - 0.00032 19.5 125.5 0.007 15.1 0.0 7.3 2 1 4 6 6 6 3 AAA domain IFT57 PF10498.9 ETS61066.1 - 0.0014 17.7 10.7 0.0014 17.7 10.7 7.5 3 2 4 7 7 7 2 Intra-flagellar transport protein 57 AAA_29 PF13555.6 ETS61066.1 - 0.019 14.7 0.0 0.043 13.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 ETS61066.1 - 0.078 12.6 2.0 0.34 10.5 0.2 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Fez1 PF06818.15 ETS61066.1 - 4.6 7.7 129.0 0.33 11.4 13.4 7.6 1 1 5 8 8 8 0 Fez1 DHHC PF01529.20 ETS61067.1 - 5.1e-37 127.0 5.0 5.1e-37 127.0 5.0 2.1 2 0 0 2 2 2 2 DHHC palmitoyltransferase Phage_holin_3_6 PF07332.11 ETS61067.1 - 0.58 10.2 2.2 0.83 9.7 0.2 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III zf-RRN7 PF11781.8 ETS61068.1 - 3.4e-07 29.8 0.1 5.6e-07 29.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ThiF PF00899.21 ETS61069.1 - 6e-19 68.4 0.0 8.6e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 ThiF family Aminotran_3 PF00202.21 ETS61070.1 - 5.4e-103 344.8 0.0 6.4e-103 344.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ETS61070.1 - 0.18 10.9 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Pkinase PF00069.25 ETS61071.1 - 3e-33 115.3 0.0 1.1e-32 113.5 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61071.1 - 8.1e-11 41.7 0.0 3.4e-10 39.6 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS61071.1 - 0.00025 20.5 0.0 0.00042 19.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETS61071.1 - 0.012 15.5 0.2 0.026 14.4 0.2 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family TFIIA_gamma_N PF02268.16 ETS61071.1 - 0.26 11.3 0.6 0.93 9.6 0.0 2.3 3 0 0 3 3 3 0 Transcription initiation factor IIA, gamma subunit, helical domain SCP2 PF02036.17 ETS61072.1 - 5.4e-10 39.7 0.0 1.1e-09 38.7 0.0 1.7 1 1 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ETS61072.1 - 0.026 14.8 0.0 0.043 14.1 0.0 1.2 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal SCP_3 PF17844.1 ETS61072.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial SCP ortholog SCP2_2 PF13530.6 ETS61072.1 - 0.16 12.4 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Sterol carrier protein domain ATG16 PF08614.11 ETS61073.1 - 0.0036 17.6 6.3 0.0036 17.6 6.3 3.4 4 0 0 4 4 4 1 Autophagy protein 16 (ATG16) MPS2 PF17060.5 ETS61073.1 - 0.014 14.7 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 F_actin_bind PF08919.10 ETS61073.1 - 0.048 13.8 0.2 0.16 12.1 0.2 1.9 1 0 0 1 1 1 0 F-actin binding MAD PF05557.13 ETS61073.1 - 0.053 11.9 5.8 0.091 11.1 5.8 1.3 1 0 0 1 1 1 0 Mitotic checkpoint protein Atg14 PF10186.9 ETS61073.1 - 0.093 11.8 4.1 0.047 12.8 1.1 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2730 PF10805.8 ETS61073.1 - 0.21 11.7 3.2 0.49 10.5 3.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Tropomyosin_1 PF12718.7 ETS61073.1 - 0.41 10.8 11.0 0.095 12.9 6.5 2.1 2 0 0 2 2 2 0 Tropomyosin like CLZ PF16526.5 ETS61073.1 - 0.84 10.0 7.0 2.2 8.7 7.0 1.7 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Sec34 PF04136.15 ETS61073.1 - 1 9.2 4.4 2 8.3 4.4 1.4 1 0 0 1 1 1 0 Sec34-like family DUF4200 PF13863.6 ETS61073.1 - 5.7 7.4 10.4 0.63 10.4 4.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) GRASP55_65 PF04495.14 ETS61074.1 - 6.1e-64 214.5 0.0 1.9e-55 186.9 0.0 2.1 2 0 0 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 ETS61074.1 - 5.9e-05 23.3 0.0 0.05 13.9 0.0 2.4 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 ETS61074.1 - 0.00017 21.3 1.0 0.4 10.6 0.0 2.8 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 ETS61074.1 - 0.064 13.6 0.0 13 6.2 0.0 2.4 2 0 0 2 2 2 0 PDZ domain SRAP PF02586.14 ETS61075.1 - 1.2e-64 217.8 0.0 2.1e-64 217.0 0.0 1.4 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) PPL5 PF18168.1 ETS61075.1 - 0.5 9.6 5.2 0.89 8.8 5.2 1.3 1 0 0 1 1 1 0 Prim-pol family 5 PGA2 PF07543.12 ETS61076.1 - 0.089 12.8 6.4 0.18 11.8 6.4 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 PBP1_TM PF14812.6 ETS61076.1 - 9 6.8 9.1 21 5.6 9.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal 2-Hacid_dh_C PF02826.19 ETS61077.1 - 6.9e-59 198.2 0.0 9.9e-59 197.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETS61077.1 - 2.3e-20 72.6 0.1 2.8e-20 72.3 0.1 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ETS61077.1 - 2.6e-07 30.9 0.0 5.1e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ETS61077.1 - 5e-05 23.8 0.0 0.00016 22.2 0.0 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.12 ETS61077.1 - 0.00099 18.7 0.2 0.004 16.7 0.1 1.9 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain adh_short PF00106.25 ETS61077.1 - 0.026 14.0 0.0 0.06 12.8 0.0 1.6 1 0 0 1 1 1 0 short chain dehydrogenase CMAS PF02353.20 ETS61078.1 - 1.1e-61 208.5 0.2 1.4e-61 208.2 0.2 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 ETS61078.1 - 2.7e-13 50.4 0.0 1.5e-10 41.6 0.0 2.6 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS61078.1 - 2.6e-12 47.3 0.0 7e-11 42.7 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS61078.1 - 3.6e-10 39.9 0.0 7.7e-10 38.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS61078.1 - 1.9e-06 27.7 0.0 5.1e-06 26.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS61078.1 - 2.7e-05 24.8 0.0 8.3e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 ETS61078.1 - 4.7e-05 23.0 0.0 0.00037 20.1 0.0 2.0 2 0 0 2 2 2 1 Histone methylation protein DOT1 MTS PF05175.14 ETS61078.1 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain FtsJ PF01728.19 ETS61078.1 - 0.046 13.8 0.0 0.082 13.0 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 ETS61078.1 - 0.057 13.2 0.0 0.094 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 ETS61078.1 - 0.15 11.5 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 Tellurite resistance protein TehB Bax1-I PF01027.20 ETS61079.1 - 1e-44 152.8 26.6 1.2e-44 152.6 26.6 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 BaxI_1 PF12811.7 ETS61079.1 - 0.0012 18.5 20.3 0.0028 17.3 20.3 1.5 1 1 0 1 1 1 1 Bax inhibitor 1 like DUF2070 PF09843.9 ETS61079.1 - 8 4.6 17.8 10 4.3 17.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) BTP PF05232.12 ETS61079.1 - 8.5 6.5 10.4 8.2 6.6 1.5 3.1 2 1 0 2 2 2 0 Chlorhexidine efflux transporter Ribosomal_S16 PF00886.19 ETS61080.1 - 4.5e-27 93.9 0.3 9.2e-27 92.9 0.1 1.6 2 0 0 2 2 2 1 Ribosomal protein S16 Lon_C PF05362.13 ETS61082.1 - 1.8e-66 223.6 0.1 3.7e-66 222.6 0.1 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 ETS61082.1 - 5.5e-33 114.6 0.1 1.4e-32 113.3 0.0 1.8 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 ETS61082.1 - 4.9e-21 75.5 0.0 1.3e-20 74.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 ETS61082.1 - 1.8e-06 27.8 0.0 4.5e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 ETS61082.1 - 3e-06 27.3 0.0 7.3e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETS61082.1 - 2e-05 24.8 0.0 5.2e-05 23.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_PrkA PF08298.11 ETS61082.1 - 4e-05 22.7 0.0 6.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 PrkA AAA domain AAA_16 PF13191.6 ETS61082.1 - 0.0013 19.2 0.0 0.0053 17.2 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETS61082.1 - 0.0021 18.4 0.1 0.063 13.5 0.1 2.6 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETS61082.1 - 0.0042 16.8 0.0 0.017 14.8 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ETS61082.1 - 0.0075 16.8 0.0 0.0075 16.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 ETS61082.1 - 0.017 15.1 0.0 0.044 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETS61082.1 - 0.021 14.6 0.0 0.052 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETS61082.1 - 0.05 13.3 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ETS61082.1 - 0.051 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 ETS61082.1 - 0.057 13.3 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Mustang PF15682.5 ETS61082.1 - 0.075 13.1 3.8 0.26 11.4 0.2 2.8 2 0 0 2 2 2 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 NB-ARC PF00931.22 ETS61082.1 - 0.075 12.2 0.1 0.14 11.3 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain MCM PF00493.23 ETS61082.1 - 0.083 12.0 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_24 PF13479.6 ETS61082.1 - 0.096 12.4 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETS61082.1 - 0.11 13.0 0.9 0.36 11.4 0.0 2.2 2 0 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 ETS61082.1 - 0.16 11.8 0.5 1.5 8.7 0.1 2.5 2 1 1 3 3 2 0 NTPase AAA_7 PF12775.7 ETS61082.1 - 0.27 10.7 0.4 1.2 8.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region PTPRCAP PF15713.5 ETS61082.1 - 3.6 7.9 12.2 0.098 12.9 4.6 2.3 2 0 0 2 2 1 0 Protein tyrosine phosphatase receptor type C-associated ADH_zinc_N PF00107.26 ETS61083.1 - 9.5e-21 74.1 0.1 1.8e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS61083.1 - 1.1e-08 34.9 0.0 2.6e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ETS61083.1 - 5.7e-07 30.7 0.0 2.2e-06 28.8 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_7 PF13241.6 ETS61083.1 - 0.084 13.3 0.0 0.18 12.3 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding ELFV_dehydrog PF00208.21 ETS61083.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase SUZ PF12752.7 ETS61084.1 - 0.76 10.6 4.6 2.7 8.8 4.6 1.8 1 1 0 1 1 1 0 SUZ domain Zn_clus PF00172.18 ETS61086.1 - 1.8e-09 37.6 7.7 2.9e-09 36.9 7.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CRC_subunit PF08624.10 ETS61087.1 - 6.4e-44 149.7 0.0 2.4e-43 147.8 0.0 1.9 2 0 0 2 2 2 1 Chromatin remodelling complex Rsc7/Swp82 subunit PAS_9 PF13426.7 ETS61088.1 - 0.06 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 PAS domain RhoGAP PF00620.27 ETS61089.1 - 3.2e-45 153.6 0.1 5.2e-45 153.0 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ETS61089.1 - 2.3e-14 53.8 0.0 4.5e-14 52.8 0.0 1.5 1 0 0 1 1 1 1 PH domain PX PF00787.24 ETS61089.1 - 3.2e-07 30.3 0.0 8.5e-07 29.0 0.0 1.7 2 0 0 2 2 2 1 PX domain HicB PF05534.12 ETS61089.1 - 0.016 15.0 1.0 0.047 13.5 1.0 1.8 1 0 0 1 1 1 0 HicB family UPF0047 PF01894.17 ETS61090.1 - 1.4e-36 125.1 0.0 2e-36 124.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PRMT5_TIM PF17285.2 ETS61091.1 - 2e-64 217.3 0.0 2.8e-64 216.8 0.0 1.2 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 ETS61091.1 - 9.6e-60 201.4 0.0 1.6e-59 200.7 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 ETS61091.1 - 1.1e-52 178.4 0.0 1.6e-52 177.9 0.0 1.2 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_25 PF13649.6 ETS61091.1 - 0.0069 17.1 0.0 0.016 15.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS61091.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SPT2 PF08243.11 ETS61092.1 - 1.5e-19 70.5 25.6 1.5e-19 70.5 25.6 6.5 4 4 2 6 6 6 1 SPT2 chromatin protein Acetyltransf_1 PF00583.25 ETS61093.1 - 1.4e-12 47.8 0.0 7.7e-07 29.4 0.0 2.1 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS61093.1 - 1.9e-09 37.8 0.0 4.1e-09 36.7 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS61093.1 - 3.9e-07 30.0 0.1 0.033 14.1 0.1 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS61093.1 - 1.5e-05 24.9 0.1 0.0041 17.1 0.0 2.3 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_9 PF13527.7 ETS61093.1 - 0.022 14.8 0.1 0.3 11.2 0.0 2.4 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ETS61093.1 - 0.03 14.3 0.0 0.058 13.4 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_CG PF14542.6 ETS61093.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CNH PF00780.22 ETS61094.1 - 1.5e-65 221.6 0.0 2.7e-65 220.7 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ETS61094.1 - 5.8e-29 101.6 0.0 9.6e-29 100.9 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain Pkinase PF00069.25 ETS61094.1 - 7.4e-17 61.6 0.0 1.4e-11 44.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain WD40 PF00400.32 ETS61094.1 - 1.1e-15 57.7 2.2 8.2e-08 32.8 0.0 6.0 5 0 0 5 5 5 2 WD domain, G-beta repeat HEAT PF02985.22 ETS61094.1 - 2.3e-09 36.7 3.6 0.22 11.9 0.0 6.7 7 0 0 7 7 7 2 HEAT repeat Pkinase_Tyr PF07714.17 ETS61094.1 - 8.5e-09 35.1 0.0 6.3e-06 25.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PH_5 PF15405.6 ETS61094.1 - 3.8e-06 27.0 0.0 0.00037 20.6 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain HEAT_2 PF13646.6 ETS61094.1 - 0.00023 21.5 0.7 12 6.4 0.1 4.3 2 1 1 3 3 3 1 HEAT repeats Kinase-like PF14531.6 ETS61094.1 - 0.0083 15.5 0.0 0.72 9.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like DEP PF00610.21 ETS61094.1 - 0.066 13.3 0.0 0.23 11.5 0.0 1.9 1 1 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Actin PF00022.19 ETS61095.1 - 3.1e-91 306.0 0.0 5.3e-90 301.9 0.0 2.0 1 1 0 1 1 1 1 Actin FtsA PF14450.6 ETS61095.1 - 0.047 14.1 0.0 0.29 11.6 0.0 2.4 2 1 0 2 2 2 0 Cell division protein FtsA PLA2_B PF01735.18 ETS61096.1 - 7.2e-142 473.2 2.2 8.8e-142 473.0 2.2 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Patatin PF01734.22 ETS61096.1 - 0.00079 19.7 0.5 0.00079 19.7 0.5 3.1 4 0 0 4 4 4 1 Patatin-like phospholipase DUF4207 PF13904.6 ETS61096.1 - 0.43 10.2 3.0 0.98 9.1 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) CDP-OH_P_transf PF01066.21 ETS61097.1 - 8.1e-17 61.8 0.2 8.1e-17 61.8 0.2 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase NAD_binding_9 PF13454.6 ETS61098.1 - 4.2e-05 23.6 0.0 0.00022 21.2 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ETS61098.1 - 0.00016 21.0 0.3 0.0033 16.7 0.2 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS61098.1 - 0.089 13.0 0.0 0.32 11.3 0.0 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ETS61098.1 - 0.1 11.3 0.2 0.24 10.0 0.1 1.6 2 0 0 2 2 2 0 HI0933-like protein Aminotran_3 PF00202.21 ETS61099.1 - 1.6e-107 359.7 0.3 2.5e-107 359.0 0.3 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Forkhead PF00250.18 ETS61099.1 - 4.5e-31 107.0 0.0 8.3e-31 106.1 0.0 1.5 1 0 0 1 1 1 1 Forkhead domain Aminotran_1_2 PF00155.21 ETS61099.1 - 0.0024 17.1 0.0 0.014 14.6 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class I and II Orn_Arg_deC_N PF02784.16 ETS61101.1 - 2.2e-73 246.7 0.0 3.2e-73 246.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ETS61101.1 - 1.3e-17 63.8 0.0 1.6e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain MFS_1 PF07690.16 ETS61102.1 - 4.3e-33 114.7 38.1 4.2e-32 111.5 34.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61102.1 - 6.8e-09 35.1 18.9 6.3e-08 31.9 18.8 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 ETS61102.1 - 0.0085 14.6 5.2 0.014 13.9 5.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) UL42 PF17638.2 ETS61102.1 - 0.019 14.9 0.4 0.098 12.6 0.1 2.1 2 0 0 2 2 2 0 HCMV UL42 DUF2178 PF09946.9 ETS61102.1 - 1.2 9.3 4.8 9.2 6.5 0.5 3.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2178) UAA PF08449.11 ETS61103.1 - 1.2e-07 31.3 17.5 1.1e-06 28.1 17.5 2.0 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETS61103.1 - 9.8e-05 22.5 5.8 9.8e-05 22.5 5.8 2.3 2 0 0 2 2 2 1 EamA-like transporter family TPT PF03151.16 ETS61103.1 - 3.1 7.1 18.6 0.12 11.6 1.3 2.1 2 0 0 2 2 2 0 Triose-phosphate Transporter family PHO4 PF01384.20 ETS61103.1 - 7.1 5.6 18.8 0.031 13.3 1.2 2.8 2 1 0 2 2 2 0 Phosphate transporter family SHR3_chaperone PF08229.11 ETS61104.1 - 1.8e-46 157.5 0.1 2.2e-46 157.2 0.1 1.1 1 0 0 1 1 1 1 ER membrane protein SH3 Neurensin PF14927.6 ETS61104.1 - 0.029 14.1 0.5 0.34 10.6 0.7 2.3 1 1 0 1 1 1 0 Neurensin DUF1772 PF08592.11 ETS61104.1 - 0.1 12.9 0.5 0.15 12.3 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) Clat_adaptor_s PF01217.20 ETS61105.1 - 5.2e-49 165.8 0.1 8.7e-36 123.0 0.1 2.0 2 0 0 2 2 2 2 Clathrin adaptor complex small chain Mito_carr PF00153.27 ETS61106.1 - 6.2e-67 221.6 5.5 7.3e-22 77.1 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein DUF1282 PF06930.12 ETS61106.1 - 0.00051 19.9 0.2 0.64 9.8 0.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1282) PBP-Tp47_a PF14889.6 ETS61106.1 - 0.081 12.6 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a OrfB_Zn_ribbon PF07282.11 ETS61107.1 - 7e-09 35.5 0.0 1.7e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain OrfB_IS605 PF01385.19 ETS61107.1 - 1.2 9.4 7.9 0.16 12.2 1.8 2.6 2 1 0 2 2 2 0 Probable transposase Ribosomal_S13 PF00416.22 ETS61108.1 - 1.8e-52 177.1 1.0 2.4e-52 176.7 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S13/S18 HHH_6 PF14579.6 ETS61108.1 - 0.0043 17.3 0.0 0.013 15.7 0.0 1.8 1 1 0 1 1 1 1 Helix-hairpin-helix motif DUF2746 PF10874.8 ETS61108.1 - 0.0048 17.3 0.0 0.0076 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2746) FbpA PF05833.11 ETS61108.1 - 0.015 14.1 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) CPSase_L_D2 PF02786.17 ETS61111.1 - 4.6e-82 274.6 0.1 7.4e-82 273.9 0.1 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 ETS61111.1 - 5.2e-69 232.0 0.0 8.5e-69 231.3 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 ETS61111.1 - 1.5e-39 134.9 0.0 3.3e-39 133.8 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ETS61111.1 - 1.1e-29 102.7 0.0 2.5e-29 101.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 ETS61111.1 - 1.4e-28 100.2 0.0 2.7e-28 99.2 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 ETS61111.1 - 5.8e-15 54.9 1.0 1.2e-14 53.9 1.0 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ETS61111.1 - 4.2e-13 48.9 0.0 2.1e-05 24.3 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 ETS61111.1 - 1.5e-09 37.7 0.0 2.8e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ETS61111.1 - 1.5e-07 31.2 0.1 4e-07 29.8 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ETS61111.1 - 3.5e-05 23.9 0.0 6.6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 ETS61111.1 - 6.4e-05 22.3 0.1 0.018 14.3 0.0 2.4 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 ETS61111.1 - 7.1e-05 23.5 0.1 0.48 11.2 0.0 2.7 2 0 0 2 2 2 2 HlyD family secretion protein RimK PF08443.11 ETS61111.1 - 0.00021 21.0 0.0 0.0007 19.2 0.0 1.9 1 1 0 1 1 1 1 RimK-like ATP-grasp domain GARS_A PF01071.19 ETS61111.1 - 0.00039 20.3 0.0 0.00073 19.4 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_4 PF13535.6 ETS61111.1 - 0.0016 18.0 0.0 0.003 17.2 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain NQRA PF05896.11 ETS61111.1 - 0.036 13.5 0.6 0.068 12.6 0.2 1.6 2 0 0 2 2 2 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATPgrasp_ST PF14397.6 ETS61111.1 - 0.053 12.8 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF2118 PF09891.9 ETS61111.1 - 0.081 12.9 0.6 2.5 8.1 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) GATA PF00320.27 ETS61112.1 - 1e-30 105.0 18.2 2e-15 56.1 3.3 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ETS61112.1 - 7.9e-06 25.3 6.4 0.021 14.3 0.2 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ETS61112.1 - 0.0004 20.4 2.2 0.41 10.8 0.3 2.7 2 0 0 2 2 2 2 Zinc ribbon domain Auto_anti-p27 PF06677.12 ETS61112.1 - 0.011 15.9 5.6 1.2 9.3 0.5 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) ArfGap PF01412.18 ETS61112.1 - 0.033 14.3 4.2 1.6 8.8 0.2 2.4 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf zf-RRN7 PF11781.8 ETS61112.1 - 0.2 11.4 6.3 0.39 10.4 0.5 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-piccolo PF05715.13 ETS61112.1 - 2.3 8.4 4.3 14 5.9 0.0 3.3 4 0 0 4 4 4 0 Piccolo Zn-finger OrfB_Zn_ribbon PF07282.11 ETS61112.1 - 2.6 8.0 6.5 3.1 7.8 0.7 2.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Vps36-NZF-N PF16988.5 ETS61112.1 - 3.3 7.2 4.9 20 4.7 0.1 3.3 3 0 0 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zinc_ribbon_4 PF13717.6 ETS61112.1 - 3.5 7.6 6.4 6.9 6.7 0.2 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Acyl-CoA_dh_1 PF00441.24 ETS61115.1 - 1.9e-50 171.0 2.4 1.9e-50 171.0 2.4 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS61115.1 - 8e-28 96.5 0.2 2e-27 95.2 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ETS61115.1 - 2e-25 89.7 0.2 5.5e-25 88.2 0.2 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ETS61115.1 - 5.7e-21 75.2 2.6 5.7e-21 75.2 2.6 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ETS61115.1 - 9.9e-07 28.7 0.3 4e-06 26.7 0.3 2.0 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal FAD-oxidase_C PF02913.19 ETS61116.1 - 4.3e-54 183.8 0.0 6.9e-54 183.1 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ETS61116.1 - 2.5e-32 111.5 0.0 4.8e-32 110.6 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Polysacc_synt_4 PF04669.13 ETS61116.1 - 3.5e-13 49.5 0.9 4.1e-12 46.1 0.9 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis AICARFT_IMPCHas PF01808.18 ETS61117.1 - 1.1e-89 300.8 0.2 1.8e-89 300.1 0.2 1.4 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 ETS61117.1 - 2.2e-22 79.1 0.0 5.1e-22 77.9 0.0 1.7 1 0 0 1 1 1 1 MGS-like domain CBM_25 PF03423.13 ETS61117.1 - 0.3 11.4 1.4 2.7 8.3 0.1 2.8 3 0 0 3 3 3 0 Carbohydrate binding domain (family 25) DPBB_1 PF03330.18 ETS61118.1 - 2.2e-05 24.7 0.1 0.00052 20.2 0.1 2.4 2 1 0 2 2 2 1 Lytic transglycolase Barwin PF00967.17 ETS61118.1 - 0.081 12.8 0.3 0.19 11.6 0.0 1.7 2 0 0 2 2 2 0 Barwin family GPHR_N PF12537.8 ETS61118.1 - 0.12 12.4 0.0 0.19 11.9 0.0 1.3 1 0 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal E1-E2_ATPase PF00122.20 ETS61120.1 - 2.3e-33 115.2 0.1 7.1e-33 113.6 0.1 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ETS61120.1 - 2.2e-26 93.5 1.1 4e-26 92.6 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ETS61120.1 - 1.5e-19 70.2 9.6 7e-07 29.6 0.1 5.1 4 1 0 4 4 4 3 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ETS61120.1 - 0.0032 17.2 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase TIR_2 PF13676.6 ETS61120.1 - 0.051 14.2 0.9 12 6.6 0.0 3.1 3 0 0 3 3 3 0 TIR domain Fer2_BFD PF04324.15 ETS61120.1 - 5.8 7.3 5.5 35 4.8 0.0 3.9 4 0 0 4 4 4 0 BFD-like [2Fe-2S] binding domain Pro_isomerase PF00160.21 ETS61121.1 - 1.7e-45 155.1 0.1 2.6e-45 154.6 0.1 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF730 PF05325.11 ETS61121.1 - 0.059 13.4 0.0 0.17 11.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF730) DUF3336 PF11815.8 ETS61122.1 - 5.8e-44 149.2 0.6 9.4e-44 148.5 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 ETS61122.1 - 4.9e-17 62.8 0.5 1.5e-16 61.2 0.0 2.1 2 1 0 2 2 2 1 Patatin-like phospholipase Efg1 PF10153.9 ETS61123.1 - 5.2e-29 100.9 6.2 5.2e-29 100.9 6.2 2.3 2 1 0 2 2 2 1 rRNA-processing protein Efg1 6PF2K PF01591.18 ETS61124.1 - 4.6e-61 206.0 0.0 6.6e-61 205.5 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ETS61124.1 - 9.6e-24 84.1 0.2 5.2e-22 78.5 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Thioredoxin PF00085.20 ETS61125.1 - 4.8e-21 74.7 0.0 6.7e-21 74.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ETS61125.1 - 0.00029 21.3 0.0 0.00045 20.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain DUF3325 PF11804.8 ETS61125.1 - 0.02 15.0 1.8 0.55 10.4 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) DBR1 PF05011.13 ETS61126.1 - 8.2e-39 133.2 0.0 2.1e-38 131.9 0.0 1.7 2 0 0 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 ETS61126.1 - 8.8e-07 29.6 0.0 1.3e-06 29.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETS61126.1 - 0.0067 16.6 0.0 0.017 15.4 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glycogen_syn PF05693.13 ETS61128.1 - 0 1117.1 0.0 0 1116.8 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 ETS61128.1 - 1.9e-07 30.8 0.0 6.3e-05 22.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ETS61128.1 - 6.6e-07 29.3 0.3 2.9e-06 27.1 0.2 2.1 1 1 1 2 2 2 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 ETS61128.1 - 3.3e-06 27.6 0.0 0.0027 18.1 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ETS61128.1 - 4.7e-05 23.9 0.1 9.6e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ETS61128.1 - 0.00021 21.3 0.8 0.00038 20.5 0.8 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Dala_Dala_lig_C PF07478.13 ETS61128.1 - 0.14 11.7 0.0 0.34 10.4 0.0 1.6 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus DUF1744 PF08490.12 ETS61130.1 - 1.8e-132 441.7 0.0 2.9e-132 441.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 ETS61130.1 - 1.2e-78 264.6 0.0 2.3e-78 263.7 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 ETS61130.1 - 3.9e-13 48.9 1.5 1.9e-11 43.4 0.7 2.9 3 1 0 3 3 3 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 ETS61130.1 - 3.5e-09 36.7 0.2 1.7e-08 34.4 0.0 2.1 2 0 0 2 2 2 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 ETS61130.1 - 1.7e-05 24.9 0.0 6.7e-05 22.9 0.0 2.0 1 0 0 1 1 1 1 RNase_H superfamily YhdX PF17444.2 ETS61130.1 - 0.12 12.3 0.7 0.33 10.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized YhdX-like Asparaginase PF00710.20 ETS61131.1 - 2.2e-54 183.9 0.0 2.4e-50 170.7 0.0 2.3 2 0 0 2 2 2 2 Asparaginase, N-terminal Asparaginase_C PF17763.1 ETS61131.1 - 5.9e-33 113.5 0.0 1.5e-32 112.2 0.0 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 ETS61131.1 - 3.3e-08 34.0 0.1 9.5e-08 32.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS61131.1 - 4.2e-05 24.0 0.1 0.0002 21.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETS61131.1 - 0.00024 21.4 2.3 0.33 11.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETS61131.1 - 0.00046 20.4 0.1 3.9 8.4 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETS61131.1 - 0.0026 18.0 0.4 0.16 12.3 0.0 3.6 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Pex14_N PF04695.13 ETS61131.1 - 0.025 15.2 1.8 0.043 14.5 0.0 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NAD_binding_10 PF13460.6 ETS61132.1 - 3.9e-08 33.4 0.1 6.1e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETS61132.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ETS61132.1 - 0.0062 17.0 0.2 0.015 15.7 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Citrate_bind PF16114.5 ETS61133.1 - 1.8e-88 294.7 0.4 8.7e-88 292.4 0.1 2.0 2 0 0 2 2 2 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 ETS61133.1 - 7.2e-20 71.4 0.0 6.1e-17 61.7 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 ETS61133.1 - 4.9e-15 55.7 0.1 9.9e-15 54.7 0.1 1.5 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 ETS61133.1 - 1.9e-13 50.9 0.0 7.5e-13 49.0 0.0 2.1 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 ETS61133.1 - 3.6e-06 26.8 0.0 1.4e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain PAC3 PF10178.9 ETS61135.1 - 0.00015 21.9 0.8 0.00035 20.7 0.8 1.6 1 1 0 1 1 1 1 Proteasome assembly chaperone 3 FHA PF00498.26 ETS61136.1 - 0.0011 19.2 0.0 0.0052 17.1 0.0 2.2 2 1 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 ETS61136.1 - 0.096 13.0 0.0 0.29 11.5 0.0 1.8 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain DTHCT PF08070.11 ETS61136.1 - 5.8 7.7 15.1 0.083 13.6 2.9 3.5 4 0 0 4 4 4 0 DTHCT (NUC029) region VHS PF00790.19 ETS61137.1 - 5.8e-40 136.4 0.0 1.7e-39 134.9 0.0 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 ETS61137.1 - 3.4e-20 72.1 0.1 1.8e-19 69.8 0.0 2.3 3 1 0 3 3 3 1 GAT domain ThiF PF00899.21 ETS61138.1 - 2.5e-72 243.2 0.1 4.1e-72 242.4 0.1 1.2 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 ETS61138.1 - 7.2e-15 55.6 0.1 5.8e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 ETS61138.1 - 1.6e-08 35.0 1.0 3.6e-08 33.9 0.3 2.0 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Shikimate_DH PF01488.20 ETS61138.1 - 0.0025 17.9 0.1 0.0063 16.6 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Ldh_1_N PF00056.23 ETS61138.1 - 0.012 15.7 0.5 0.17 12.0 0.1 2.4 2 0 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ETS61138.1 - 0.015 15.9 0.2 0.55 10.8 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ETS61138.1 - 0.024 15.1 0.1 0.079 13.4 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ETS61138.1 - 0.64 10.3 3.5 0.73 10.1 0.6 2.6 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain RRM_1 PF00076.22 ETS61139.1 - 4.4e-16 58.5 0.0 7.2e-16 57.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ETS61139.1 - 1.1e-06 29.1 1.0 1.1e-06 29.1 1.0 2.3 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_3 PF08777.11 ETS61139.1 - 0.047 13.8 0.0 0.098 12.7 0.0 1.5 1 0 0 1 1 1 0 RNA binding motif RRM_7 PF16367.5 ETS61139.1 - 0.085 13.0 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif CBS PF00571.28 ETS61140.1 - 1.9e-07 31.4 1.3 0.00016 22.0 0.1 4.0 5 0 0 5 5 5 2 CBS domain DASH_Ask1 PF08655.10 ETS61141.1 - 2e-27 94.8 0.1 3.5e-27 94.1 0.1 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 IF-2B PF01008.17 ETS61142.1 - 6.6e-56 189.6 0.5 1.9e-49 168.4 0.0 2.1 2 0 0 2 2 2 2 Initiation factor 2 subunit family PBP1_TM PF14812.6 ETS61142.1 - 0.0046 17.3 3.0 0.0082 16.5 3.0 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal PPP4R2 PF09184.11 ETS61142.1 - 0.0065 16.1 5.1 0.01 15.5 5.1 1.2 1 0 0 1 1 1 1 PPP4R2 CENP-B_dimeris PF09026.10 ETS61142.1 - 0.0067 16.8 7.6 0.014 15.7 7.6 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Nop14 PF04147.12 ETS61142.1 - 0.041 12.1 6.5 0.057 11.6 6.5 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2076 PF09849.9 ETS61142.1 - 0.048 13.7 10.6 0.087 12.9 10.6 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Serglycin PF04360.12 ETS61142.1 - 0.14 12.1 0.1 0.14 12.1 0.1 2.3 2 0 0 2 2 2 0 Serglycin DUF2457 PF10446.9 ETS61142.1 - 0.16 11.1 17.4 0.24 10.5 17.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FAM176 PF14851.6 ETS61142.1 - 0.4 10.3 4.2 0.78 9.4 4.2 1.5 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 ETS61142.1 - 0.47 10.5 4.6 0.83 9.7 4.6 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 ETS61142.1 - 0.64 9.7 11.6 1.1 9.0 11.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETS61142.1 - 1 8.6 11.6 1.6 8.0 11.6 1.2 1 0 0 1 1 1 0 NOA36 protein Nucleo_P87 PF07267.11 ETS61142.1 - 1.6 7.5 3.4 2.3 7.0 3.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RRN3 PF05327.11 ETS61142.1 - 3.3 6.1 6.5 5.1 5.5 6.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETS61142.1 - 4.2 5.4 18.9 2.8 5.9 15.7 1.8 2 0 0 2 2 2 0 DNA polymerase phi Pex24p PF06398.11 ETS61143.1 - 9.3e-05 21.6 6.8 0.00014 21.0 6.8 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin SPT6_acidic PF14632.6 ETS61144.1 - 0.0038 17.8 3.1 0.0038 17.8 3.1 5.4 4 2 1 5 5 5 2 Acidic N-terminal SPT6 SAM_decarbox PF01536.16 ETS61145.1 - 6.3e-128 426.7 0.0 9.4e-128 426.2 0.0 1.2 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase DUF4201 PF13870.6 ETS61147.1 - 0.00088 19.0 5.3 0.00088 19.0 5.3 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF4201) DUF4763 PF15960.5 ETS61147.1 - 0.13 11.6 7.2 1.8 7.8 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Spc7 PF08317.11 ETS61147.1 - 0.79 8.5 13.5 0.63 8.9 6.7 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein ATG16 PF08614.11 ETS61147.1 - 1.9 8.7 25.1 0.092 13.0 12.0 3.4 3 0 0 3 3 3 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ETS61147.1 - 3.1 8.2 17.1 1 9.8 7.5 2.7 3 0 0 3 3 3 0 Fez1 Csm1_N PF18504.1 ETS61147.1 - 5.5 7.4 14.5 1.3 9.4 0.7 3.8 2 1 1 3 3 3 0 Csm1 N-terminal domain Tyr-DNA_phospho PF06087.12 ETS61149.1 - 3e-37 128.5 0.0 6e-37 127.5 0.0 1.5 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase DFRP_C PF16543.5 ETS61149.1 - 3e-30 104.5 3.3 3e-30 104.5 3.3 3.7 4 0 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf_CCCH_4 PF18345.1 ETS61149.1 - 0.0038 17.2 7.1 0.0038 17.2 7.1 3.2 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_3 PF15663.5 ETS61149.1 - 0.0074 16.5 0.4 0.26 11.5 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH PF00642.24 ETS61149.1 - 0.15 12.0 4.6 0.076 13.0 1.7 2.0 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PTPS PF01242.19 ETS61149.1 - 0.2 11.7 1.9 5.9 6.9 0.1 2.4 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase zf-CCCH_2 PF14608.6 ETS61149.1 - 2.5 8.7 10.1 9.7 6.8 3.0 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ras PF00071.22 ETS61150.1 - 1.6e-58 196.9 0.1 1.9e-58 196.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61150.1 - 9.6e-21 74.2 0.0 1.6e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61150.1 - 5.7e-09 35.7 0.0 6.8e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS61150.1 - 8.7e-06 25.4 0.1 2.2e-05 24.1 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETS61150.1 - 0.00013 21.9 0.3 0.25 11.3 0.0 2.4 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ETS61150.1 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ETS61150.1 - 0.0099 15.7 1.2 0.12 12.2 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 ETS61150.1 - 0.01 15.4 0.0 0.029 13.9 0.0 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Ser_hydrolase PF06821.13 ETS61150.1 - 0.081 12.8 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase G-alpha PF00503.20 ETS61150.1 - 0.12 11.6 0.2 3.3 6.8 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Csm1 PF12539.8 ETS61151.1 - 4.1e-06 27.3 0.0 1.3e-05 25.7 0.0 1.9 1 1 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 DUF2852 PF11014.8 ETS61151.1 - 0.011 15.9 1.5 0.047 13.9 1.5 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) MOSC_N PF03476.16 ETS61152.1 - 1.5e-20 73.3 0.0 2.7e-20 72.5 0.0 1.5 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain MOSC PF03473.17 ETS61152.1 - 4e-20 72.1 0.0 8.1e-20 71.2 0.0 1.5 1 1 0 1 1 1 1 MOSC domain Glyco_tran_28_C PF04101.16 ETS61153.1 - 2.1e-18 66.8 0.0 7.3e-14 52.1 0.0 2.2 2 0 0 2 2 2 2 Glycosyltransferase family 28 C-terminal domain EphA2_TM PF14575.6 ETS61154.1 - 0.044 14.7 0.0 0.11 13.4 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UQ_con PF00179.26 ETS61156.1 - 2.5e-53 179.5 0.0 2.8e-53 179.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETS61156.1 - 0.0029 17.9 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 ETS61156.1 - 0.0062 16.2 0.0 0.0078 15.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ETS61156.1 - 0.044 13.6 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 UEV domain Skp1_POZ PF03931.15 ETS61157.1 - 1.5e-09 37.9 0.0 4.7e-09 36.3 0.0 1.8 1 1 0 1 1 1 1 Skp1 family, tetramerisation domain RNase_PH PF01138.21 ETS61158.1 - 6.5e-10 39.6 0.0 1.1e-09 38.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ETS61158.1 - 1.1e-09 38.1 0.0 2.9e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 DUF3602 PF12223.8 ETS61159.1 - 8.5e-16 58.3 23.3 2.4e-13 50.5 5.7 4.1 2 1 2 4 4 4 3 Protein of unknown function (DUF3602) EF-hand_6 PF13405.6 ETS61160.1 - 1e-13 50.0 0.7 1.3e-05 24.7 0.1 3.4 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 ETS61160.1 - 1.9e-13 50.7 0.3 3e-07 30.8 0.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETS61160.1 - 2.8e-12 45.3 1.8 1.1e-05 24.7 0.1 3.4 5 0 0 5 5 5 2 EF hand EF-hand_9 PF14658.6 ETS61160.1 - 1.1e-05 25.7 0.0 0.001 19.3 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ETS61160.1 - 1.1e-05 25.2 0.3 0.0038 17.0 0.0 3.2 2 2 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ETS61160.1 - 0.00012 21.4 0.4 0.0036 16.7 0.2 2.7 2 0 0 2 2 2 1 EF hand EFhand_Ca_insen PF08726.10 ETS61160.1 - 0.006 16.7 0.0 0.95 9.6 0.0 2.2 2 0 0 2 2 2 1 Ca2+ insensitive EF hand FGAR-AT_linker PF18072.1 ETS61160.1 - 0.16 12.5 0.0 16 6.2 0.0 2.4 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain EF-hand_11 PF08976.11 ETS61160.1 - 0.2 12.5 0.0 0.83 10.6 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain ATP-synt_G PF04718.15 ETS61161.1 - 1.5e-15 57.8 0.2 2.9e-15 56.9 0.1 1.5 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit DUF5399 PF17377.2 ETS61161.1 - 0.12 12.2 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5399) DUF1674 PF07896.12 ETS61161.1 - 0.16 12.4 0.2 1.3 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1674) LRR_6 PF13516.6 ETS61162.1 - 5.7e-06 26.0 0.1 1.9 8.8 0.0 5.1 5 0 0 5 5 5 2 Leucine Rich repeat F-box PF00646.33 ETS61162.1 - 0.017 15.0 0.1 0.06 13.2 0.1 2.0 1 0 0 1 1 1 0 F-box domain Fibrillarin PF01269.17 ETS61162.1 - 0.13 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin IU_nuc_hydro PF01156.19 ETS61163.1 - 3e-84 283.2 0.0 4.2e-84 282.7 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase HSP70 PF00012.20 ETS61164.1 - 4.6e-251 834.2 16.7 4.6e-251 834.2 16.7 2.6 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ETS61164.1 - 1.6e-16 60.0 0.4 2e-15 56.4 0.1 2.6 2 1 0 2 2 2 1 MreB/Mbl protein zf-U1 PF06220.12 ETS61164.1 - 1.9e-07 30.7 0.8 3.8e-07 29.8 0.8 1.5 1 0 0 1 1 1 1 U1 zinc finger Hydantoinase_A PF01968.18 ETS61164.1 - 0.0042 16.4 5.1 0.12 11.6 0.1 3.2 3 0 0 3 3 3 2 Hydantoinase/oxoprolinase DUF4624 PF15417.6 ETS61164.1 - 0.023 14.5 0.0 0.79 9.5 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4624) TRAF_BIRC3_bd PF16673.5 ETS61164.1 - 0.25 11.1 1.7 2.6 7.9 0.4 2.9 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DUF2680 PF10925.8 ETS61164.1 - 0.81 9.7 8.8 0.13 12.3 0.2 3.8 4 1 0 4 4 4 0 Protein of unknown function (DUF2680) Ank_4 PF13637.6 ETS61165.1 - 1.6e-13 50.9 0.2 2.4e-06 28.0 0.0 2.8 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS61165.1 - 1.3e-10 41.7 0.1 5.5e-08 33.3 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETS61165.1 - 2.2e-10 40.6 0.0 2.6e-08 34.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETS61165.1 - 1.9e-06 27.7 0.0 4e-05 23.7 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ETS61165.1 - 1e-05 25.7 0.3 4.2e-05 23.8 0.2 2.1 3 0 0 3 3 3 1 Ankyrin repeat Elf1 PF05129.13 ETS61166.1 - 8.6e-30 102.6 0.7 9.6e-30 102.5 0.7 1.0 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zf-Sec23_Sec24 PF04810.15 ETS61166.1 - 0.079 13.0 3.7 4.3 7.5 0.1 2.4 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger SPX PF03105.19 ETS61167.1 - 0.88 9.4 6.1 0.83 9.5 6.1 1.1 1 0 0 1 1 1 0 SPX domain SOG2 PF10428.9 ETS61167.1 - 2.3 7.3 15.8 2.5 7.2 15.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein HSD3 PF15244.6 ETS61167.1 - 2.8 7.4 9.0 3.5 7.0 9.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 PPC PF04151.15 ETS61167.1 - 4.5 8.5 11.3 19 6.4 11.2 2.3 1 1 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain SNF2_N PF00176.23 ETS61168.1 - 1.5e-42 145.6 0.0 2.4e-42 144.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS61168.1 - 1.1e-21 77.2 0.0 2.1e-20 73.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain VIGSSK PF14773.6 ETS61168.1 - 3e-12 46.5 0.0 8.8e-12 45.0 0.0 1.8 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal ResIII PF04851.15 ETS61168.1 - 5.2e-06 26.6 0.0 1.1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ETS61168.1 - 0.00024 20.4 0.0 0.00049 19.4 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase RPE65 PF03055.15 ETS61169.1 - 3.5e-118 395.8 0.0 4.1e-118 395.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein zf-C3HC4 PF00097.25 ETS61170.1 - 6.3e-08 32.4 7.3 2.1e-07 30.7 7.3 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 ETS61170.1 - 1.2e-07 31.4 3.0 1.2e-07 31.4 3.0 3.0 4 0 0 4 4 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS61170.1 - 1.2e-07 31.5 12.8 9.6e-07 28.7 6.0 2.6 2 0 0 2 2 2 1 Zinc finger domain zf-C3HC4_3 PF13920.6 ETS61170.1 - 3.1e-06 26.9 6.2 6.3e-06 26.0 6.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH_4 PF18044.1 ETS61170.1 - 1.3e-05 24.9 3.7 1.3e-05 24.9 3.7 2.3 2 0 0 2 2 2 1 CCCH-type zinc finger zf-RING_2 PF13639.6 ETS61170.1 - 1.4e-05 25.3 9.0 4.5e-05 23.7 9.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETS61170.1 - 0.00014 21.6 9.7 0.00043 20.1 9.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS61170.1 - 0.00019 21.3 8.1 0.0005 20.0 8.1 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETS61170.1 - 0.00029 20.8 6.7 0.00029 20.8 6.7 2.0 2 0 0 2 2 1 1 RING-type zinc-finger Torus PF16131.5 ETS61170.1 - 0.0021 18.7 0.8 0.037 14.7 0.1 2.5 2 0 0 2 2 2 1 Torus domain zf-CCCH_2 PF14608.6 ETS61170.1 - 0.0023 18.3 2.2 0.0023 18.3 2.2 3.3 3 0 0 3 3 2 1 RNA-binding, Nab2-type zinc finger Prok-RING_4 PF14447.6 ETS61170.1 - 0.0024 17.7 6.0 0.0068 16.2 6.0 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ETS61170.1 - 0.011 15.9 4.6 0.033 14.3 4.6 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 ETS61170.1 - 0.013 15.6 5.8 0.038 14.1 5.8 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-rbx1 PF12678.7 ETS61170.1 - 0.02 15.2 8.0 0.056 13.7 8.0 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain CEBP_ZZ PF16366.5 ETS61170.1 - 0.06 13.6 6.6 0.16 12.3 6.6 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain PhnA_Zn_Ribbon PF08274.12 ETS61170.1 - 0.061 13.3 3.6 6.8 6.7 0.1 2.7 2 0 0 2 2 2 0 PhnA Zinc-Ribbon zf-ANAPC11 PF12861.7 ETS61170.1 - 0.083 12.9 1.9 0.19 11.8 1.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 ETS61170.1 - 0.15 12.0 1.9 0.32 10.9 1.9 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Zn_ribbon_17 PF17120.5 ETS61170.1 - 0.23 11.1 7.0 0.7 9.6 7.0 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type DUF3583 PF12126.8 ETS61170.1 - 0.45 9.9 4.3 0.81 9.1 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) NTP_transf_9 PF04248.12 ETS61171.1 - 1.3e-31 108.3 1.0 4.1e-31 106.7 0.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF427) DCP2 PF05026.13 ETS61171.1 - 4e-25 87.9 0.0 6.5e-25 87.3 0.0 1.3 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 ETS61171.1 - 2.5e-14 53.5 0.0 5e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain TAL_FSA PF00923.19 ETS61171.1 - 0.24 10.7 0.0 0.37 10.1 0.0 1.2 1 0 0 1 1 1 0 Transaldolase/Fructose-6-phosphate aldolase NGP1NT PF08153.12 ETS61172.1 - 8.9e-47 158.5 0.0 2.1e-46 157.3 0.0 1.6 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 ETS61172.1 - 1.1e-16 60.9 0.3 6.2e-14 52.1 0.0 2.8 3 0 0 3 3 3 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ETS61172.1 - 8.4e-06 25.4 0.2 2.8e-05 23.7 0.1 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 ETS61172.1 - 0.00045 19.7 0.1 0.068 12.6 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETS61172.1 - 0.0037 17.2 0.0 0.011 15.7 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 ETS61172.1 - 1.3 9.0 8.1 0.93 9.5 0.0 3.8 4 1 1 5 5 5 0 Dynamin family SIR2 PF02146.17 ETS61173.1 - 8.1e-58 195.2 0.0 1.6e-57 194.3 0.0 1.5 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 ETS61173.1 - 2.5e-09 37.1 0.3 1.4e-05 24.9 0.1 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF592) HTH_Crp_2 PF13545.6 ETS61173.1 - 0.0097 15.9 0.0 0.073 13.1 0.0 2.2 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain CutC PF03932.14 ETS61173.1 - 0.02 14.4 0.0 0.055 12.9 0.0 1.6 2 0 0 2 2 2 0 CutC family DUF1323 PF07037.11 ETS61173.1 - 0.027 14.9 0.0 0.065 13.6 0.0 1.6 1 0 0 1 1 1 0 Putative transcription regulator (DUF1323) Metallothio_Cad PF07846.11 ETS61173.1 - 0.13 12.4 3.9 0.22 11.7 3.9 1.3 1 0 0 1 1 1 0 Metallothionein family ADK PF00406.22 ETS61174.1 - 7.2e-05 22.9 0.0 0.021 14.9 0.0 2.3 2 0 0 2 2 2 2 Adenylate kinase AAA_33 PF13671.6 ETS61174.1 - 0.067 13.4 0.0 0.24 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ETS61174.1 - 0.083 13.2 0.0 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETS61174.1 - 0.098 13.2 0.0 0.28 11.7 0.0 1.7 2 0 0 2 2 2 0 ABC transporter Rad17 PF03215.15 ETS61174.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain Cys_Met_Meta_PP PF01053.20 ETS61175.1 - 1.1e-137 458.7 0.0 2e-137 457.8 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ETS61175.1 - 0.089 12.1 0.0 0.31 10.3 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family DHHA2 PF02833.14 ETS61177.1 - 2e-17 63.7 0.2 3e-17 63.1 0.2 1.3 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 ETS61177.1 - 2.9e-08 33.9 0.0 6.4e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 DHH family Ribonuc_2-5A PF06479.12 ETS61177.1 - 0.2 11.9 3.8 4.2 7.6 0.3 2.5 2 1 0 2 2 2 0 Ribonuclease 2-5A SNARE_assoc PF09335.11 ETS61178.1 - 5.5e-31 107.5 6.3 2.9e-30 105.2 6.5 2.1 2 0 0 2 2 2 1 SNARE associated Golgi protein SHMT PF00464.19 ETS61179.1 - 3.7e-175 582.3 0.0 4.5e-175 582.0 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 ETS61179.1 - 0.014 14.7 0.1 0.033 13.5 0.1 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase FA_desaturase PF00487.24 ETS61180.1 - 9.2e-15 55.2 27.6 9.2e-15 55.2 27.6 1.5 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 ETS61180.1 - 1.6e-13 50.6 0.1 3e-13 49.7 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Axin_b-cat_bind PF08833.10 ETS61180.1 - 0.13 12.4 0.5 4.8 7.4 0.0 2.6 2 0 0 2 2 2 0 Axin beta-catenin binding domain RGS PF00615.19 ETS61181.1 - 1.7e-12 47.7 0.0 6.8e-07 29.6 0.0 2.5 2 1 0 2 2 2 2 Regulator of G protein signaling domain Pkinase PF00069.25 ETS61182.1 - 9.9e-50 169.3 0.0 4.3e-47 160.7 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61182.1 - 8.5e-22 77.7 0.0 6.8e-19 68.2 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS61182.1 - 0.0014 17.5 0.1 0.0034 16.2 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ETS61182.1 - 0.0081 16.1 1.0 0.048 13.6 1.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETS61182.1 - 0.013 14.8 0.0 0.029 13.7 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Kdo PF06293.14 ETS61182.1 - 0.042 13.2 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETS61182.1 - 0.13 11.1 0.0 0.13 11.1 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Kin17_mid PF10357.9 ETS61183.1 - 2.4e-48 163.2 0.4 4e-48 162.5 0.4 1.4 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 ETS61183.1 - 9e-06 25.8 1.8 1.7e-05 25.0 1.8 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETS61183.1 - 1.3e-05 25.4 1.6 2.6e-05 24.4 1.6 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ETS61183.1 - 0.0097 16.2 0.7 0.029 14.7 0.0 2.0 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) AKAP95 PF04988.12 ETS61183.1 - 0.025 14.8 0.6 0.025 14.8 0.6 1.8 2 0 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) GCP_N_terminal PF17681.1 ETS61184.1 - 1.9e-85 287.2 0.0 1e-84 284.8 0.0 2.1 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ETS61184.1 - 9e-75 252.0 0.5 2.2e-74 250.7 0.0 1.9 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal RasGAP PF00616.19 ETS61185.1 - 1.7e-59 201.0 0.0 4.5e-59 199.7 0.0 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ETS61185.1 - 4.6e-40 136.9 0.2 4.6e-40 136.9 0.2 2.3 3 0 0 3 3 3 1 RasGAP C-terminus YabA PF06156.13 ETS61185.1 - 0.026 15.2 2.1 4.6 7.9 0.1 3.3 2 0 0 2 2 2 0 Initiation control protein YabA SANT_DAMP1_like PF16282.5 ETS61186.1 - 6.7e-32 109.5 1.1 1.1e-31 108.8 1.1 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_6 PF13921.6 ETS61186.1 - 0.099 12.9 0.0 0.32 11.3 0.0 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain NAT PF04768.13 ETS61187.1 - 2.3e-48 164.1 0.0 4.4e-48 163.1 0.0 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 ETS61187.1 - 5.7e-28 98.1 0.5 2.5e-27 96.0 0.0 2.3 2 0 0 2 2 2 1 Amino acid kinase family Semialdhyde_dh PF01118.24 ETS61187.1 - 5.3e-26 91.4 0.0 1.4e-25 90.0 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 ETS61187.1 - 2e-12 47.6 0.8 3.2e-12 46.9 0.0 1.8 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, dimerisation domain HLH PF00010.26 ETS61187.1 - 4.4e-09 36.2 0.1 1e-08 35.0 0.1 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DapB_N PF01113.20 ETS61187.1 - 0.11 12.6 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus DUF659 PF04937.15 ETS61187.1 - 0.2 11.5 0.0 0.46 10.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) Phage_Mu_Gam PF07352.12 ETS61187.1 - 1.2 9.1 4.0 3.1 7.7 4.0 1.7 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein SUIM_assoc PF16619.5 ETS61187.1 - 4.4 7.5 14.1 2.6e+02 1.8 14.1 2.7 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L24e PF01246.20 ETS61189.1 - 1.3e-24 86.1 2.5 1.2e-20 73.5 0.6 2.5 2 0 0 2 2 2 2 Ribosomal protein L24e Aminotran_1_2 PF00155.21 ETS61190.1 - 9.4e-53 179.7 0.0 2.1e-49 168.6 0.0 2.7 2 1 0 2 2 2 2 Aminotransferase class I and II OKR_DC_1 PF01276.20 ETS61190.1 - 0.0018 17.1 0.0 0.0031 16.3 0.0 1.3 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Beta_elim_lyase PF01212.21 ETS61190.1 - 0.0066 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ETS61190.1 - 0.18 10.7 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V LSM PF01423.22 ETS61192.1 - 1.3e-19 69.6 0.5 1.5e-19 69.4 0.5 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ETS61192.1 - 5.3e-06 26.5 0.1 6.4e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 ETS61192.1 - 0.00018 21.5 0.2 0.0002 21.4 0.2 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain Velvet PF11754.8 ETS61193.1 - 2.9e-51 174.8 8.8 1.2e-33 117.1 0.1 3.2 3 1 1 4 4 4 2 Velvet factor GCD14 PF08704.10 ETS61194.1 - 4.4e-81 272.2 2.3 7e-45 153.6 0.4 3.2 2 1 1 3 3 3 3 tRNA methyltransferase complex GCD14 subunit TRM13 PF05206.14 ETS61194.1 - 0.12 11.9 0.3 14 5.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 Radical_SAM PF04055.21 ETS61194.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily GATA PF00320.27 ETS61195.1 - 1.3e-12 47.1 5.9 3.1e-12 45.9 5.9 1.7 1 0 0 1 1 1 1 GATA zinc finger PAS_4 PF08448.10 ETS61195.1 - 0.0073 16.5 0.1 0.038 14.2 0.0 2.3 2 0 0 2 2 2 1 PAS fold PAS_3 PF08447.12 ETS61195.1 - 0.026 14.8 0.0 0.054 13.8 0.0 1.5 1 0 0 1 1 1 0 PAS fold Kinesin PF00225.23 ETS61196.1 - 1.4e-111 372.6 0.0 2.9e-111 371.6 0.0 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETS61196.1 - 5.9e-27 94.4 0.0 1.4e-26 93.3 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Drf_GBD PF06371.13 ETS61197.1 - 3.5e-10 39.8 0.0 3.4e-06 26.8 0.0 2.3 2 0 0 2 2 2 2 Diaphanous GTPase-binding Domain Rcd1 PF04078.13 ETS61197.1 - 0.032 13.5 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Cell differentiation family, Rcd1-like Peptidase_M41 PF01434.18 ETS61198.1 - 3.1e-64 216.4 0.0 6.2e-64 215.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ETS61198.1 - 1.5e-42 145.1 0.0 3.7e-42 143.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS61198.1 - 2.3e-12 46.5 0.1 6e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 ETS61198.1 - 2.6e-10 40.6 0.2 1.4e-09 38.3 0.0 2.2 2 0 0 2 2 2 1 FtsH Extracellular AAA_16 PF13191.6 ETS61198.1 - 0.0028 18.0 0.1 0.16 12.3 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 ETS61198.1 - 0.0041 16.4 0.0 0.0071 15.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 ETS61198.1 - 0.0048 17.2 0.0 0.42 10.9 0.0 2.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETS61198.1 - 0.015 15.1 0.0 0.035 13.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ETS61198.1 - 0.019 15.1 0.2 0.084 13.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ETS61198.1 - 0.02 14.9 0.0 0.083 12.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ETS61198.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 ETS61198.1 - 0.34 10.6 5.5 8.5 6.1 0.1 2.7 2 0 0 2 2 2 0 AAA domain Mo25 PF08569.11 ETS61199.1 - 1.3e-134 448.7 0.7 2e-134 448.1 0.7 1.3 1 1 0 1 1 1 1 Mo25-like Spore_GerQ PF09671.10 ETS61199.1 - 0.016 15.2 0.0 0.04 13.9 0.0 1.7 1 0 0 1 1 1 0 Spore coat protein (Spore_GerQ) GP40 PF11025.8 ETS61199.1 - 0.11 12.2 5.5 0.19 11.5 5.5 1.3 1 0 0 1 1 1 0 Glycoprotein GP40 of Cryptosporidium SR-25 PF10500.9 ETS61199.1 - 9.2 5.8 10.7 14 5.2 10.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Methyltransf_15 PF09445.10 ETS61200.1 - 1.4e-32 112.6 0.0 2e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Met_10 PF02475.16 ETS61200.1 - 2.4e-07 30.7 0.0 3.5e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 ETS61200.1 - 0.0067 16.1 0.0 0.03 13.9 0.0 2.0 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 ETS61200.1 - 0.0091 16.7 0.0 0.02 15.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ETS61200.1 - 0.02 14.3 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_3 PF01596.17 ETS61200.1 - 0.06 12.5 0.0 0.098 11.8 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase UPF0020 PF01170.18 ETS61200.1 - 0.097 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 tRNA_U5-meth_tr PF05958.11 ETS61200.1 - 0.18 10.8 0.0 0.25 10.3 0.0 1.1 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Abhydrolase_3 PF07859.13 ETS61201.1 - 8.3e-18 65.0 0.0 8.9e-16 58.4 0.0 2.6 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETS61201.1 - 3.7e-10 39.2 0.0 1.5e-09 37.2 0.0 1.8 2 0 0 2 2 2 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 ETS61201.1 - 0.062 13.9 2.6 0.21 12.2 2.5 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family UCH PF00443.29 ETS61202.1 - 6.5e-42 143.8 0.0 1.5e-41 142.6 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS61202.1 - 4.6e-18 65.9 0.0 3.9e-10 39.8 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ETS61202.1 - 6.7e-12 45.6 2.2 6.7e-12 45.6 2.2 2.5 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein HSP70 PF00012.20 ETS61203.1 - 3.4e-62 210.5 4.9 5.7e-56 189.9 0.0 2.8 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETS61203.1 - 0.0033 16.3 0.2 0.0085 14.9 0.2 1.6 1 0 0 1 1 1 1 MreB/Mbl protein Ras PF00071.22 ETS61204.1 - 3e-54 183.0 0.1 4.1e-54 182.5 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61204.1 - 1.7e-31 108.9 0.0 2.8e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61204.1 - 4.2e-13 49.1 0.0 1.2e-12 47.7 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETS61204.1 - 0.0019 17.6 0.0 0.0025 17.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS61204.1 - 0.0025 17.9 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS61204.1 - 0.0044 16.6 0.0 0.0055 16.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ETS61204.1 - 0.041 14.3 0.2 0.097 13.1 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain CBFD_NFYB_HMF PF00808.23 ETS61205.1 - 5.8e-15 55.3 0.8 5.8e-15 55.3 0.8 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ETS61205.1 - 8.3e-05 23.0 0.2 0.00013 22.4 0.2 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 PCI PF01399.27 ETS61206.1 - 6.3e-05 23.4 0.0 0.00016 22.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain ANAPC3 PF12895.7 ETS61206.1 - 0.0024 18.0 4.2 0.036 14.3 4.2 2.5 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ETS61206.1 - 0.07 13.8 2.6 3 8.7 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETS61206.1 - 0.078 13.2 1.3 0.35 11.2 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETS61206.1 - 0.11 12.6 4.8 0.77 10.0 0.3 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETS61206.1 - 0.33 11.5 3.1 5.7 7.5 1.2 3.2 2 1 0 2 2 2 0 Tetratricopeptide repeat SPT_ssu-like PF11779.8 ETS61207.1 - 8e-15 54.2 5.0 1.1e-14 53.8 5.0 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like AF-4 PF05110.13 ETS61207.1 - 0.0025 16.0 8.6 0.0031 15.7 8.6 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein G-patch PF01585.23 ETS61208.1 - 1.5e-12 47.2 1.1 6.2e-12 45.2 0.7 2.4 2 0 0 2 2 2 1 G-patch domain R3H PF01424.22 ETS61208.1 - 1e-09 38.2 0.0 2.1e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 R3H domain G-patch_2 PF12656.7 ETS61208.1 - 1.3e-05 25.1 0.9 7.4e-05 22.8 0.9 2.5 1 0 0 1 1 1 1 G-patch domain AAA_22 PF13401.6 ETS61208.1 - 0.14 12.5 0.6 1 9.7 0.0 2.6 3 0 0 3 3 3 0 AAA domain DUF4722 PF15849.5 ETS61208.1 - 0.17 11.6 1.2 0.31 10.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4722) EF-hand_7 PF13499.6 ETS61209.1 - 1.1e-28 99.4 13.3 1.2e-14 54.5 4.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETS61209.1 - 1.2e-26 90.2 18.2 1.8e-09 36.4 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETS61209.1 - 7.1e-24 81.7 14.5 2.6e-08 33.1 0.1 4.5 4 1 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ETS61209.1 - 8.1e-17 60.8 14.4 1.1e-10 41.2 1.8 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ETS61209.1 - 8.1e-13 47.2 15.1 1.3e-05 24.5 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 ETS61209.1 - 4e-11 43.1 2.3 0.00016 21.9 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETS61209.1 - 9.1e-08 32.0 3.8 0.0011 18.9 0.1 2.4 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Caleosin PF05042.13 ETS61209.1 - 0.0002 21.4 2.8 0.058 13.3 0.0 3.6 1 1 3 4 4 4 1 Caleosin related protein EF-hand_14 PF17959.1 ETS61209.1 - 0.0075 16.6 3.3 0.57 10.6 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETS61209.1 - 0.028 14.8 4.2 1.2 9.4 0.5 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1636 PF07845.11 ETS61209.1 - 0.031 14.7 0.0 1.3 9.4 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1636) SurA_N_2 PF13623.6 ETS61209.1 - 0.047 13.6 1.0 1.2 9.0 0.2 2.4 2 1 0 2 2 2 0 SurA N-terminal domain ResIII PF04851.15 ETS61210.1 - 7.1e-22 78.2 0.0 1.8e-21 76.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETS61210.1 - 6.9e-21 74.7 0.0 1.4e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS61210.1 - 7.5e-18 64.9 0.0 5.8e-17 62.0 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ETS61210.1 - 0.0086 15.8 0.0 0.018 14.7 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF4808 PF16066.5 ETS61210.1 - 0.098 13.2 0.2 2.4 8.7 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) 60KD_IMP PF02096.20 ETS61211.1 - 4.9e-09 36.3 0.0 1e-08 35.3 0.0 1.5 1 1 0 1 1 1 1 60Kd inner membrane protein NEMP PF10225.9 ETS61211.1 - 0.14 11.9 0.5 3.1 7.4 0.1 2.1 2 0 0 2 2 2 0 NEMP family IGR PF09597.10 ETS61212.1 - 3.2e-12 46.4 0.7 6.9e-12 45.3 0.7 1.6 1 1 0 1 1 1 1 IGR protein motif Glyoxal_oxid_N PF07250.11 ETS61213.1 - 2.5e-41 141.4 0.8 3.3e-31 108.3 0.0 3.6 2 1 1 3 3 3 3 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ETS61213.1 - 1e-25 89.8 0.1 2e-25 88.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Tfb4 PF03850.14 ETS61214.1 - 1.5e-72 244.4 5.7 4.8e-71 239.5 5.7 2.1 1 1 0 1 1 1 1 Transcription factor Tfb4 DEAD PF00270.29 ETS61215.1 - 2.9e-37 128.1 0.0 6.3e-37 127.0 0.0 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS61215.1 - 1.4e-22 80.1 0.0 3.8e-21 75.5 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS61215.1 - 4.3e-08 33.4 0.0 1.1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETS61215.1 - 0.0024 18.2 0.0 0.0059 16.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETS61215.1 - 0.035 14.4 1.3 0.51 10.6 1.3 2.6 1 1 0 1 1 1 0 AAA domain PIEZO PF15917.5 ETS61215.1 - 1.2 8.5 4.1 2.5 7.5 4.1 1.5 1 0 0 1 1 1 0 Piezo BUD22 PF09073.10 ETS61215.1 - 1.3 8.3 29.2 2.8 7.2 29.2 1.5 1 0 0 1 1 1 0 BUD22 Hid1 PF12722.7 ETS61216.1 - 0.39 8.8 0.9 0.45 8.6 0.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rep_fac_C PF08542.11 ETS61217.1 - 5.1e-05 23.6 0.1 0.00046 20.6 0.0 2.4 3 0 0 3 3 3 1 Replication factor C C-terminal domain Rad17 PF03215.15 ETS61217.1 - 0.00037 20.5 0.1 0.00086 19.3 0.0 1.6 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 ETS61217.1 - 0.0041 17.5 0.0 0.011 16.1 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 ETS61217.1 - 0.012 16.0 0.4 0.04 14.3 0.4 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ETS61217.1 - 0.016 15.0 0.0 0.037 13.8 0.0 1.6 1 1 0 1 1 1 0 DNA polymerase III, delta subunit RuvB_N PF05496.12 ETS61217.1 - 0.02 14.6 0.1 0.45 10.3 0.0 2.2 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rpr2 PF04032.16 ETS61217.1 - 0.047 14.0 0.1 0.11 12.8 0.1 1.7 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain AAA_24 PF13479.6 ETS61217.1 - 0.06 13.1 0.1 0.16 11.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETS61217.1 - 0.087 13.3 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 ETS61217.1 - 0.1 12.6 0.1 0.24 11.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) NTP_transf_2 PF01909.23 ETS61218.1 - 2.1e-05 24.7 0.0 4.9e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 ETS61218.1 - 0.00023 21.3 0.1 0.001 19.2 0.1 2.2 1 1 0 1 1 1 1 Cid1 family poly A polymerase BEX PF04538.12 ETS61218.1 - 0.018 15.7 0.2 0.018 15.7 0.2 3.1 3 0 0 3 3 3 0 Brain expressed X-linked like family SUZ PF12752.7 ETS61219.1 - 2e-13 50.9 1.0 2e-13 50.9 1.0 2.5 2 1 0 2 2 2 1 SUZ domain Mito_carr PF00153.27 ETS61221.1 - 3.3e-65 216.0 5.2 3.6e-24 84.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 ETS61221.1 - 0.073 12.2 0.1 0.28 10.3 0.0 1.8 2 0 0 2 2 2 0 Fuseless TSC22 PF01166.18 ETS61222.1 - 0.13 12.6 2.1 0.38 11.1 2.1 1.8 1 0 0 1 1 1 0 TSC-22/dip/bun family RBR PF17208.3 ETS61222.1 - 0.35 11.6 3.7 0.49 11.1 0.1 3.0 2 0 0 2 2 2 0 RNA binding Region bZIP_1 PF00170.21 ETS61222.1 - 1.6 8.9 15.7 3.6 7.7 15.7 1.6 1 0 0 1 1 1 0 bZIP transcription factor DNA_pol_phi PF04931.13 ETS61222.1 - 9.4 4.2 36.1 3.2 5.7 32.5 1.8 2 0 0 2 2 2 0 DNA polymerase phi GTP_EFTU PF00009.27 ETS61223.1 - 3.8e-52 176.7 0.1 6.3e-52 176.0 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETS61223.1 - 2.1e-41 140.8 0.0 4.4e-41 139.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETS61223.1 - 1.1e-12 48.2 1.3 1.1e-12 48.2 1.3 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETS61223.1 - 0.0021 18.1 0.1 0.052 13.6 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF3234 PF11572.8 ETS61223.1 - 0.1 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3234) FlpD PF02662.16 ETS61223.1 - 0.1 12.6 0.0 0.51 10.3 0.0 2.2 3 0 0 3 3 3 0 Methyl-viologen-reducing hydrogenase, delta subunit TAFII55_N PF04658.13 ETS61224.1 - 1.8e-53 180.6 0.0 1.8e-53 180.6 0.0 1.8 2 0 0 2 2 2 1 TAFII55 protein conserved region Ribosomal_L32e PF01655.18 ETS61225.1 - 1.3e-48 163.9 1.5 1.5e-48 163.7 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 CaATP_NAI PF12515.8 ETS61225.1 - 4.4 7.0 6.5 0.48 10.1 0.9 2.3 3 0 0 3 3 3 0 Ca2+-ATPase N terminal autoinhibitory domain Ribosomal_L13 PF00572.18 ETS61226.1 - 1e-10 42.0 0.1 9.3e-10 38.8 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 FRG1 PF06229.12 ETS61227.1 - 1.3e-19 70.7 3.3 1.3e-17 64.2 3.3 3.1 1 1 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 ETS61227.1 - 1.7e-05 25.0 0.0 3.5e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Fascin domain SPT2 PF08243.11 ETS61227.1 - 0.0057 17.2 0.8 0.0057 17.2 0.8 2.4 3 0 0 3 3 3 1 SPT2 chromatin protein DUF4504 PF14953.6 ETS61228.1 - 2.1e-12 47.0 0.6 2.9e-10 40.0 0.6 2.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4504) Sld7_C PF18596.1 ETS61229.1 - 0.1 12.8 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Sld7 C-terminal domain ubiquitin PF00240.23 ETS61231.1 - 1.6e-19 69.4 0.1 2.4e-19 68.9 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETS61231.1 - 3.4e-08 33.2 0.3 5.5e-08 32.5 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETS61231.1 - 2.8e-06 27.8 0.0 4.9e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain UBA PF00627.31 ETS61231.1 - 3.3e-06 26.9 0.4 1.1e-05 25.3 0.4 2.0 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 ETS61231.1 - 0.00088 19.4 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETS61231.1 - 0.023 14.8 0.3 1.6 8.8 0.3 2.2 1 1 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ETS61231.1 - 0.077 13.5 0.1 0.19 12.2 0.1 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain GerD PF17898.1 ETS61231.1 - 0.34 10.9 11.5 4.3 7.3 11.5 2.2 1 1 0 1 1 1 0 Spore germination GerD central core domain DUF726 PF05277.12 ETS61232.1 - 6.1e-57 193.1 0.7 8.9e-57 192.6 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_6 PF12697.7 ETS61232.1 - 0.002 18.7 0.1 0.006 17.2 0.1 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.8 ETS61232.1 - 0.043 13.4 0.0 0.088 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PE-PPE PF08237.11 ETS61232.1 - 0.13 11.8 0.0 0.22 11.0 0.0 1.3 1 0 0 1 1 1 0 PE-PPE domain Hydrolase_4 PF12146.8 ETS61232.1 - 0.14 11.4 0.0 0.39 9.9 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Meth_synt_2 PF01717.18 ETS61233.1 - 5.9e-151 502.3 0.0 9.5e-143 475.3 0.0 3.0 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ETS61233.1 - 4.1e-119 397.7 0.0 1.2e-112 376.5 0.1 2.8 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 ETS61233.1 - 0.00032 19.9 0.1 0.044 12.9 0.0 2.6 3 0 0 3 3 3 2 Uroporphyrinogen decarboxylase (URO-D) SHOCT PF09851.9 ETS61233.1 - 0.065 13.0 0.6 0.15 11.8 0.6 1.7 1 0 0 1 1 1 0 Short C-terminal domain RabGAP-TBC PF00566.18 ETS61234.1 - 7.6e-50 169.5 0.0 1.2e-49 168.9 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 ETS61234.1 - 5.1e-06 26.4 0.0 1e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Metallophos PF00149.28 ETS61235.1 - 3.4e-35 122.4 0.2 7.8e-35 121.2 0.1 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETS61235.1 - 0.034 14.6 0.1 0.14 12.7 0.0 2.1 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain DUF1647 PF07801.11 ETS61235.1 - 0.063 13.0 0.8 2.8 7.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) DUF771 PF05595.11 ETS61235.1 - 0.071 13.1 0.3 4.2 7.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF771) DEPP PF15343.6 ETS61236.1 - 0.11 12.5 0.5 0.16 12.0 0.5 1.2 1 0 0 1 1 1 0 Decidual protein induced by progesterone family Totivirus_coat PF05518.11 ETS61236.1 - 3.5 5.5 7.3 4.2 5.3 7.3 1.1 1 0 0 1 1 1 0 Totivirus coat protein Glyco_hydro_16 PF00722.21 ETS61237.1 - 9.2e-39 132.7 1.8 2.6e-38 131.2 1.8 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SpoIIIAH PF12685.7 ETS61237.1 - 3.6 7.3 7.4 0.21 11.4 1.3 1.8 2 0 0 2 2 2 0 SpoIIIAH-like protein Chitin_bind_1 PF00187.19 ETS61237.1 - 4.7 7.8 14.7 12 6.5 14.7 1.6 1 0 0 1 1 1 0 Chitin recognition protein Spc7 PF08317.11 ETS61239.1 - 0.099 11.5 0.2 0.16 10.8 0.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3712 PF12505.8 ETS61240.1 - 3.2e-100 331.1 39.7 1.1e-22 80.6 0.0 8.7 9 0 0 9 9 9 6 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ETS61240.1 - 0.0003 21.3 21.3 1.5 9.4 0.1 7.9 8 0 0 8 8 8 3 Late embryogenesis abundant protein Shisa PF13908.6 ETS61241.1 - 1 9.6 4.5 28 4.9 0.0 2.4 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Proteasome PF00227.26 ETS61243.1 - 2.6e-33 115.1 0.0 6.4e-33 113.8 0.0 1.6 1 1 0 1 1 1 1 Proteasome subunit MamL-1 PF09596.10 ETS61243.1 - 0.18 12.1 0.2 0.34 11.2 0.2 1.4 1 0 0 1 1 1 0 MamL-1 domain Cullin PF00888.22 ETS61244.1 - 2.7e-12 46.1 0.0 4.6e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Cullin family TetR_C_22 PF17928.1 ETS61244.1 - 0.97 9.8 5.9 20 5.5 0.2 3.8 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RNase_PH PF01138.21 ETS61245.1 - 9.6e-32 110.3 0.0 1.6e-31 109.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ETS61245.1 - 0.00051 20.0 0.0 0.0013 18.7 0.0 1.7 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 GalKase_gal_bdg PF10509.9 ETS61245.1 - 0.11 12.1 0.4 0.3 10.7 0.1 1.9 2 0 0 2 2 2 0 Galactokinase galactose-binding signature AMP-binding PF00501.28 ETS61246.1 - 3.1e-82 276.4 0.0 9e-82 274.9 0.0 1.6 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS61246.1 - 2.8e-08 34.6 1.0 1.7e-07 32.1 0.1 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DUF3433 PF11915.8 ETS61246.1 - 0.055 13.9 0.1 0.14 12.6 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3433) Metallophos PF00149.28 ETS61249.1 - 6.9e-06 26.7 2.8 6.9e-06 26.7 2.8 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase HGTP_anticodon2 PF12745.7 ETS61249.1 - 0.23 10.9 3.6 0.36 10.3 3.6 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CDC45 PF02724.14 ETS61249.1 - 1.2 7.3 6.2 1.9 6.7 6.2 1.2 1 0 0 1 1 1 0 CDC45-like protein UAA PF08449.11 ETS61251.1 - 1.3e-78 264.3 1.2 1.8e-78 263.8 1.2 1.2 1 0 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 ETS61251.1 - 0.0043 16.3 2.3 0.0043 16.3 2.3 2.4 2 1 1 3 3 3 1 Purine nucleobase transmembrane transport CRT-like PF08627.10 ETS61251.1 - 0.0076 15.2 0.1 0.0076 15.2 0.1 1.7 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like EMP70 PF02990.16 ETS61251.1 - 1.6 7.3 5.0 5.1 5.7 5.0 1.8 1 1 0 1 1 1 0 Endomembrane protein 70 SURF1 PF02104.15 ETS61252.1 - 1.9e-44 152.0 0.0 2.6e-44 151.5 0.0 1.2 1 0 0 1 1 1 1 SURF1 family YTH PF04146.15 ETS61255.1 - 1.7e-60 203.7 9.2 8.1e-60 201.5 9.2 2.1 1 1 0 1 1 1 1 YT521-B-like domain RRM_1 PF00076.22 ETS61255.1 - 0.00052 19.8 0.0 1.2 9.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dus PF01207.17 ETS61256.1 - 2.9e-71 240.1 0.0 9.6e-71 238.4 0.0 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) adh_short PF00106.25 ETS61257.1 - 1.8e-16 60.2 0.0 1.2e-10 41.2 0.0 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS61257.1 - 6.6e-10 38.9 0.1 1.8e-05 24.4 0.0 3.1 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS61257.1 - 0.00074 19.5 0.1 0.0014 18.5 0.1 1.4 1 0 0 1 1 1 1 KR domain Bromodomain PF00439.25 ETS61258.1 - 8.3e-17 61.0 0.0 1.5e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Bromodomain XhlA PF10779.9 ETS61258.1 - 0.32 11.2 1.2 0.93 9.7 1.2 1.8 1 0 0 1 1 1 0 Haemolysin XhlA Methyltransf_25 PF13649.6 ETS61259.1 - 4.3e-05 24.1 0.0 0.043 14.5 0.0 3.2 3 0 0 3 3 3 1 Methyltransferase domain PrmA PF06325.13 ETS61259.1 - 9.9e-05 21.9 0.1 0.0002 20.9 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ETS61259.1 - 0.00066 19.6 0.1 0.0012 18.7 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain PRMT5_C PF17286.2 ETS61259.1 - 0.0059 16.5 0.0 0.022 14.6 0.0 1.9 1 1 0 1 1 1 1 PRMT5 oligomerisation domain Methyltransf_32 PF13679.6 ETS61259.1 - 0.0073 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS61259.1 - 0.015 14.9 0.0 0.039 13.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_9 PF08003.11 ETS61259.1 - 0.019 13.9 0.0 0.031 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 ETS61259.1 - 0.019 15.6 0.0 1.9 9.2 0.0 2.8 3 0 0 3 3 3 0 Methyltransferase domain DREV PF05219.12 ETS61259.1 - 0.046 12.8 0.0 0.083 12.0 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Cellulase PF00150.18 ETS61260.1 - 5.9e-12 45.6 9.0 3e-11 43.3 9.0 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AA_kinase PF00696.28 ETS61263.1 - 2.2e-38 132.2 0.3 5.4e-36 124.4 0.1 2.9 2 1 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 ETS61263.1 - 2.6e-12 46.3 0.2 3.6e-06 26.6 0.1 2.8 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 ETS61263.1 - 1.4e-09 37.6 1.3 8.9e-07 28.6 0.2 2.6 2 0 0 2 2 2 2 ACT domain FAM176 PF14851.6 ETS61264.1 - 0.67 9.6 2.6 3.3 7.4 2.6 2.2 1 0 0 1 1 1 0 FAM176 family RNA_lig_T4_1 PF09511.10 ETS61265.1 - 7.7e-79 264.6 0.0 1.2e-78 264.0 0.0 1.3 1 0 0 1 1 1 1 RNA ligase tRNA_lig_CPD PF08302.11 ETS61265.1 - 1e-25 90.7 0.0 7.7e-25 87.8 0.0 2.2 1 1 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 ETS61265.1 - 1.9e-19 70.4 0.0 3.6e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain AAA_33 PF13671.6 ETS61265.1 - 0.015 15.5 0.0 0.62 10.2 0.0 2.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ETS61265.1 - 0.054 13.9 0.0 0.14 12.5 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETS61265.1 - 0.16 12.5 0.0 0.43 11.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF3381 PF11861.8 ETS61265.1 - 1.8 8.3 9.8 3.3 7.5 9.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Prefoldin_2 PF01920.20 ETS61266.1 - 8.9e-22 77.1 15.0 1e-21 76.8 15.0 1.1 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 ETS61266.1 - 0.0013 18.8 6.4 0.0017 18.4 6.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit Snf7 PF03357.21 ETS61266.1 - 0.01 15.5 4.7 0.01 15.5 4.7 2.0 2 0 0 2 2 2 1 Snf7 Macoilin PF09726.9 ETS61266.1 - 0.013 14.1 10.3 0.015 13.9 10.3 1.0 1 0 0 1 1 1 0 Macoilin family PHM7_cyt PF14703.6 ETS61266.1 - 0.016 15.5 7.6 0.033 14.4 7.6 1.6 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF4349 PF14257.6 ETS61266.1 - 0.019 14.4 7.1 0.022 14.2 6.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) BRE1 PF08647.11 ETS61266.1 - 0.044 13.8 2.1 0.044 13.8 2.1 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase DUF1192 PF06698.11 ETS61266.1 - 0.047 13.7 1.3 0.047 13.7 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) Bcr-Abl_Oligo PF09036.10 ETS61266.1 - 0.077 13.0 0.5 0.077 13.0 0.5 1.7 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Fib_alpha PF08702.10 ETS61266.1 - 0.13 12.4 11.0 0.27 11.4 11.0 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Occludin_ELL PF07303.13 ETS61266.1 - 0.18 12.6 7.2 0.13 13.0 2.9 2.0 1 1 1 2 2 2 0 Occludin homology domain Rx_N PF18052.1 ETS61266.1 - 0.24 11.7 5.6 0.11 12.8 1.1 2.1 1 1 0 2 2 2 0 Rx N-terminal domain Lge1 PF11488.8 ETS61266.1 - 0.35 11.1 11.9 0.23 11.7 6.3 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 Tropomyosin_1 PF12718.7 ETS61266.1 - 0.4 10.8 14.6 0.4 10.8 3.7 2.2 1 1 1 2 2 2 0 Tropomyosin like Prefoldin PF02996.17 ETS61266.1 - 0.46 10.4 13.5 0.12 12.3 5.0 2.1 1 1 1 2 2 2 0 Prefoldin subunit Fez1 PF06818.15 ETS61266.1 - 0.72 10.3 11.8 0.41 11.1 1.9 2.1 1 1 1 2 2 2 0 Fez1 UPF0242 PF06785.11 ETS61266.1 - 0.93 9.6 13.6 1.2 9.2 13.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 ETS61266.1 - 1.1 9.6 10.5 8 6.8 10.5 1.9 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 ETS61266.1 - 1.4 7.9 7.7 1.7 7.6 7.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 ETS61266.1 - 2.9 8.6 10.0 4.6 7.9 2.0 2.1 1 1 1 2 2 2 0 Initiation control protein YabA MIP-T3_C PF17749.1 ETS61266.1 - 4.8 7.1 14.1 0.62 10.0 5.6 2.1 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region DUF4200 PF13863.6 ETS61266.1 - 5.5 7.4 16.5 16 5.9 16.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) ABC_tran_CTD PF16326.5 ETS61266.1 - 5.7 7.3 11.3 0.62 10.4 2.8 2.5 2 2 0 2 2 2 0 ABC transporter C-terminal domain ZapB PF06005.12 ETS61266.1 - 6.3 7.3 16.6 6.4 7.3 7.1 2.2 1 1 1 2 2 2 0 Cell division protein ZapB NPV_P10 PF05531.12 ETS61266.1 - 6.4 7.3 9.5 2.3 8.8 3.4 2.1 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 ETS61266.1 - 6.7 5.9 8.2 11 5.2 8.2 1.4 1 1 0 1 1 1 0 TMPIT-like protein DivIC PF04977.15 ETS61266.1 - 7.3 6.4 14.5 5.3 6.9 4.0 2.4 2 0 0 2 2 2 0 Septum formation initiator Swi5 PF07061.11 ETS61266.1 - 8.3 6.6 11.6 6.8 6.9 1.7 2.3 1 1 1 2 2 2 0 Swi5 DNA_pol_A_exo1 PF01612.20 ETS61267.1 - 2e-16 60.2 0.0 3.4e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease Ribosomal_S17e PF00833.18 ETS61268.1 - 2.4e-57 192.2 0.0 4.6e-57 191.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal S17 Ribosomal_S8 PF00410.19 ETS61269.1 - 1.1e-21 77.1 0.0 1.5e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Glyco_hydro_8 PF01270.17 ETS61270.1 - 2.2e-20 72.8 0.0 6.2e-20 71.3 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 8 tRNA-synt_2b PF00587.25 ETS61271.1 - 4.5e-37 127.8 0.0 8.6e-37 126.8 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ETS61271.1 - 1.9e-20 73.1 9.4 1.9e-20 73.1 9.4 1.8 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain MIP-T3_C PF17749.1 ETS61271.1 - 0.0013 18.7 3.9 0.0023 17.9 3.9 1.3 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 C-terminal region NuA4 PF09340.10 ETS61271.1 - 0.018 14.9 0.2 0.083 12.8 0.0 2.3 2 0 0 2 2 2 0 Histone acetyltransferase subunit NuA4 DUF3829 PF12889.7 ETS61271.1 - 0.021 14.3 4.2 0.04 13.4 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) tRNA-synt_His PF13393.6 ETS61271.1 - 0.25 10.6 1.3 0.49 9.6 0.0 1.9 2 0 0 2 2 2 0 Histidyl-tRNA synthetase DUF5082 PF16888.5 ETS61271.1 - 0.3 11.4 4.2 0.33 11.2 1.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) YPEB PF14620.6 ETS61271.1 - 0.33 10.2 6.4 0.64 9.3 6.4 1.5 1 1 0 1 1 1 0 YpeB sporulation CHASE3 PF05227.13 ETS61271.1 - 0.79 9.6 5.2 13 5.7 3.2 2.5 2 0 0 2 2 2 0 CHASE3 domain OEP PF02321.18 ETS61271.1 - 1.1 9.0 6.1 2.3 8.0 6.1 1.5 1 0 0 1 1 1 0 Outer membrane efflux protein DUF724 PF05266.14 ETS61271.1 - 1.1 9.0 8.6 0.29 11.0 4.7 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF724) APG6_N PF17675.1 ETS61271.1 - 2.3 8.7 8.7 2 8.9 6.6 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region RAC_head PF16717.5 ETS61272.1 - 2.4e-20 73.3 7.6 2.4e-20 73.3 7.6 3.1 4 0 0 4 4 4 1 Ribosome-associated complex head domain DnaJ PF00226.31 ETS61272.1 - 3.7e-18 65.4 0.1 3.7e-18 65.4 0.1 2.3 2 1 0 2 2 2 1 DnaJ domain Lge1 PF11488.8 ETS61272.1 - 0.63 10.3 0.1 0.63 10.3 0.1 2.9 2 1 1 3 3 3 0 Transcriptional regulatory protein LGE1 Presenilin PF01080.17 ETS61272.1 - 2.9 6.5 8.6 4.8 5.8 8.6 1.4 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETS61272.1 - 8.6 5.3 10.0 16 4.4 10.0 1.5 1 0 0 1 1 1 0 Solute carrier family 12 Ribosomal_L44 PF00935.19 ETS61273.1 - 1.7e-33 114.9 9.8 1.7e-33 114.9 9.8 1.7 2 0 0 2 2 2 1 Ribosomal protein L44 Fmp27_SW PF10305.9 ETS61273.1 - 0.091 13.5 0.0 0.36 11.6 0.0 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Ribosomal_L14e PF01929.17 ETS61274.1 - 6.3e-31 106.7 0.7 8.6e-31 106.3 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 ETS61274.1 - 6.6e-05 22.7 0.5 0.00011 22.0 0.5 1.3 1 0 0 1 1 1 1 KOW motif UCH PF00443.29 ETS61275.1 - 7.1e-36 124.0 0.0 3.7e-32 111.8 0.0 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS61275.1 - 0.16 11.5 0.0 4 6.9 0.0 2.8 3 0 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase DUF3984 PF13136.6 ETS61276.1 - 3.6 6.9 7.1 5.4 6.3 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) THOC7 PF05615.13 ETS61277.1 - 2.3e-24 86.2 9.5 2.3e-24 86.2 9.5 2.3 1 1 1 2 2 2 1 Tho complex subunit 7 DUF2853 PF11015.8 ETS61277.1 - 0.00081 20.0 0.4 0.088 13.5 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2853) DUF4407 PF14362.6 ETS61277.1 - 0.0025 17.2 5.9 0.0058 16.0 5.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 ETS61277.1 - 0.012 15.6 7.3 0.012 15.6 7.3 2.0 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Arfaptin PF06456.13 ETS61277.1 - 0.02 14.5 1.1 0.02 14.5 1.1 2.0 1 1 0 2 2 2 0 Arfaptin-like domain ZapB PF06005.12 ETS61277.1 - 0.024 15.1 4.8 3.2 8.3 1.1 2.7 2 0 0 2 2 2 0 Cell division protein ZapB DUF1664 PF07889.12 ETS61277.1 - 0.025 14.6 6.0 0.26 11.3 2.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) GTP-bdg_M PF16360.5 ETS61277.1 - 0.062 13.9 13.2 0.096 13.3 3.0 3.6 3 0 0 3 3 3 0 GTP-binding GTPase Middle Region Snapin_Pallidin PF14712.6 ETS61277.1 - 0.11 13.0 5.9 0.87 10.1 0.7 2.6 2 1 1 3 3 3 0 Snapin/Pallidin KxDL PF10241.9 ETS61277.1 - 0.21 11.9 3.5 11 6.4 0.4 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein APG6_N PF17675.1 ETS61277.1 - 0.32 11.5 12.7 2.7 8.5 0.2 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF3135 PF11333.8 ETS61277.1 - 0.45 10.8 2.5 2.6 8.4 0.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3135) Fungal_TACC PF12709.7 ETS61277.1 - 0.58 10.6 6.5 0.45 11.0 1.0 2.6 3 0 0 3 3 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins FUSC PF04632.12 ETS61277.1 - 0.59 8.6 11.7 0.9 8.0 11.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Med21 PF11221.8 ETS61277.1 - 0.75 10.1 13.7 2.1 8.6 0.6 3.0 1 1 2 3 3 3 0 Subunit 21 of Mediator complex V_ATPase_I PF01496.19 ETS61277.1 - 1.1 7.1 2.7 1.7 6.5 2.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2408 PF10303.9 ETS61277.1 - 1.4 9.5 7.2 22 5.6 7.2 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Fzo_mitofusin PF04799.13 ETS61277.1 - 1.4 8.5 6.3 6.1 6.4 0.1 2.2 1 1 1 2 2 2 0 fzo-like conserved region DUF2205 PF10224.9 ETS61277.1 - 1.7 8.7 9.1 3 7.9 0.1 3.0 3 0 0 3 3 3 0 Short coiled-coil protein Spc24 PF08286.11 ETS61277.1 - 3 8.1 9.2 1.8 8.8 2.9 2.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DivIC PF04977.15 ETS61277.1 - 7 6.5 9.1 14 5.5 2.3 2.5 1 1 1 2 2 2 0 Septum formation initiator SKN1 PF03935.15 ETS61278.1 - 4.7e-204 678.4 1.3 5.8e-204 678.1 1.3 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) zf-CCHC PF00098.23 ETS61279.1 - 1.3e-39 132.6 51.1 9e-09 35.0 2.1 6.2 6 0 0 6 6 6 6 Zinc knuckle zf-CCHC_3 PF13917.6 ETS61279.1 - 7.2e-09 35.5 29.0 0.32 11.0 0.1 6.1 4 2 2 6 6 6 6 Zinc knuckle zf-CCHC_4 PF14392.6 ETS61279.1 - 0.00046 19.9 33.7 0.13 12.1 2.0 5.7 6 0 0 6 6 6 4 Zinc knuckle zf-CCHC_5 PF14787.6 ETS61279.1 - 0.016 14.9 31.7 1.2 8.9 2.0 6.1 6 0 0 6 6 6 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 ETS61279.1 - 0.057 13.2 1.3 0.057 13.2 1.3 6.3 6 0 0 6 6 6 0 Zinc knuckle ProRS-C_1 PF09180.11 ETS61280.1 - 1.3e-24 86.2 1.5 3.2e-24 84.9 1.5 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 ETS61280.1 - 7.2e-21 74.1 0.0 2.2e-20 72.6 0.0 1.9 1 0 0 1 1 1 1 Anticodon binding domain tRNA_edit PF04073.15 ETS61280.1 - 1.8e-18 66.8 0.5 3.1e-18 66.0 0.5 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2b PF00587.25 ETS61280.1 - 1.6e-16 60.8 0.0 3.4e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Fer2 PF00111.27 ETS61281.1 - 1.8e-11 43.8 0.2 2.6e-11 43.3 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain adh_short_C2 PF13561.6 ETS61282.1 - 1.3e-54 185.3 0.2 1.9e-54 184.7 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS61282.1 - 2.8e-43 147.7 0.1 3.7e-43 147.3 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS61282.1 - 4.4e-10 39.8 0.4 7e-10 39.1 0.4 1.3 1 0 0 1 1 1 1 KR domain Glyco_hydro_2_C PF02836.17 ETS61283.1 - 1.6e-14 53.7 0.0 3e-13 49.6 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ETS61283.1 - 4.5e-11 42.9 1.7 1.3e-10 41.4 1.7 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ETS61283.1 - 5e-07 30.4 0.0 9.9e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 TraF_2 PF13729.6 ETS61284.1 - 1 8.6 13.8 6.9 6.0 0.1 3.4 2 2 1 3 3 3 0 F plasmid transfer operon, TraF, protein NPV_P10 PF05531.12 ETS61284.1 - 1.3 9.6 13.2 6.7 7.3 3.5 4.2 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein LUC7 PF03194.15 ETS61284.1 - 5.8 6.5 30.1 2 8.0 9.5 3.3 1 1 2 3 3 3 0 LUC7 N_terminus UPF0184 PF03670.13 ETS61284.1 - 7.8 7.0 11.7 49 4.4 5.2 4.5 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0184) Baculo_PEP_C PF04513.12 ETS61284.1 - 9.4 6.3 10.1 45 4.1 3.7 3.3 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tmemb_14 PF03647.13 ETS61285.1 - 4e-22 78.8 6.5 4.5e-22 78.6 6.5 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C ASFV_J13L PF05568.11 ETS61286.1 - 0.013 15.2 0.1 0.046 13.5 0.0 2.0 2 0 0 2 2 2 0 African swine fever virus J13L protein VCBS PF13517.6 ETS61286.1 - 0.025 15.2 2.2 1.9 9.1 0.4 3.1 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella LapA_dom PF06305.11 ETS61286.1 - 0.052 13.4 0.8 0.13 12.0 0.2 1.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Syndecan PF01034.20 ETS61286.1 - 0.16 11.9 0.3 0.33 10.9 0.3 1.4 1 0 0 1 1 1 0 Syndecan domain Gram_pos_anchor PF00746.21 ETS61286.1 - 0.97 9.4 3.2 3.3 7.7 3.2 2.0 1 0 0 1 1 1 0 LPXTG cell wall anchor motif PCI PF01399.27 ETS61287.1 - 4.1e-08 33.7 0.0 1e-07 32.4 0.0 1.7 1 0 0 1 1 1 1 PCI domain TPR_19 PF14559.6 ETS61287.1 - 0.098 13.2 2.5 0.89 10.1 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat CMAS PF02353.20 ETS61290.1 - 3.7e-65 219.9 0.0 8.2e-53 179.5 0.0 3.0 2 1 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ETS61290.1 - 1.1e-09 38.8 0.0 3.5e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS61290.1 - 4.8e-09 36.3 0.0 8.1e-09 35.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS61290.1 - 4.2e-08 33.7 0.0 1e-07 32.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS61290.1 - 6.5e-07 29.3 0.0 1.6e-06 28.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 ETS61290.1 - 0.0073 15.4 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_12 PF08242.12 ETS61290.1 - 0.016 15.9 0.0 0.038 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 ETS61290.1 - 0.049 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 ETS61290.1 - 0.16 11.7 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CAP59_mtransfer PF11735.8 ETS61291.1 - 2.2e-76 256.8 0.2 2.9e-76 256.3 0.2 1.2 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Glyco_tranf_2_4 PF13704.6 ETS61291.1 - 0.032 14.7 0.1 0.082 13.4 0.1 1.8 1 0 0 1 1 1 0 Glycosyl transferase family 2 Metallophos PF00149.28 ETS61292.1 - 4.1e-18 66.6 0.3 9.2e-18 65.5 0.3 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ETS61292.1 - 4.6e-16 59.4 0.2 1.1e-15 58.2 0.2 1.7 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 ETS61292.1 - 1.5e-15 57.5 0.4 3e-15 56.5 0.4 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos_2 PF12850.7 ETS61292.1 - 0.007 16.6 0.0 0.083 13.1 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PhoD_N PF16655.5 ETS61292.1 - 0.081 13.5 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain Fer2_3 PF13085.6 ETS61293.1 - 8.9e-32 109.3 0.0 1.5e-31 108.6 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 ETS61293.1 - 2.7e-09 37.4 7.3 2.7e-09 37.4 7.3 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ETS61293.1 - 3.8e-07 30.5 8.0 3.8e-07 30.5 8.0 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 ETS61293.1 - 4.9e-06 26.6 3.6 4.9e-06 26.6 3.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 ETS61293.1 - 0.0019 18.8 6.1 0.0019 18.8 6.1 2.2 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 ETS61293.1 - 0.0081 16.1 0.5 0.0081 16.1 0.5 2.2 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_9 PF13187.6 ETS61293.1 - 0.77 10.0 13.4 0.34 11.1 8.8 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain SH3_9 PF14604.6 ETS61294.1 - 7e-22 77.0 0.4 1.6e-13 50.3 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ETS61294.1 - 2.9e-18 65.2 0.0 4.5e-08 32.6 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ETS61294.1 - 1.4e-14 53.5 0.0 1.4e-08 34.3 0.0 2.3 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 ETS61294.1 - 3.3e-12 46.1 3.6 6.3e-12 45.2 3.6 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) FCH PF00611.23 ETS61294.1 - 5.3e-12 45.8 0.8 2.1e-11 44.0 0.1 2.4 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain GPI-anchored PF10342.9 ETS61294.1 - 0.048 14.4 0.3 0.32 11.8 0.1 2.2 2 0 0 2 2 2 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SH3_3 PF08239.11 ETS61294.1 - 0.069 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain Med9 PF07544.13 ETS61294.1 - 0.079 13.1 0.3 0.25 11.5 0.0 2.0 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Mod_r PF07200.13 ETS61294.1 - 0.32 11.1 9.4 0.41 10.7 0.6 3.4 4 0 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DUF2417 PF10329.9 ETS61295.1 - 0.12 11.8 2.9 0.22 10.9 2.9 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) DUF3619 PF12279.8 ETS61295.1 - 0.93 9.8 3.3 5.5 7.3 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3619) Complex1_LYR PF05347.15 ETS61296.1 - 2.4e-11 43.5 1.3 3.5e-11 43.0 1.3 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ETS61296.1 - 0.019 15.7 0.1 0.028 15.1 0.1 1.3 1 0 0 1 1 1 0 Complex1_LYR-like MFS_1 PF07690.16 ETS61297.1 - 1.6e-37 129.3 51.0 3.7e-37 128.1 47.5 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETS61297.1 - 1.2e-11 43.8 23.4 2.6e-11 42.6 23.3 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Fungal_trans PF04082.18 ETS61298.1 - 3.1e-10 39.5 0.6 4.6e-10 39.0 0.6 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61298.1 - 9.7e-07 28.8 9.1 9.7e-07 28.8 9.1 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 ETS61299.1 - 3.8e-17 62.2 22.2 2.5e-09 36.5 6.3 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily OATP PF03137.20 ETS61299.1 - 0.001 17.4 1.7 0.001 17.4 1.7 1.8 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 ETS61299.1 - 0.0041 16.0 17.1 0.013 14.4 1.9 2.6 3 0 0 3 3 3 2 Sugar (and other) transporter Ferric_reduct PF01794.19 ETS61300.1 - 1.7e-17 63.7 15.6 1.7e-17 63.7 15.6 1.7 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ETS61300.1 - 2.2e-11 44.1 0.0 9e-08 32.4 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ETS61300.1 - 5.3e-06 26.5 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ETS61301.1 - 1.3e-20 73.8 17.5 2.3e-20 73.0 16.1 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ETS61301.1 - 2.5e-13 50.5 0.0 5.5e-13 49.3 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ETS61301.1 - 0.00013 22.0 0.0 0.0003 20.8 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Alpha-L-AF_C PF06964.12 ETS61302.1 - 3.4e-27 95.6 0.0 7.1e-27 94.6 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase C-terminal domain CBM_4_9 PF02018.17 ETS61302.1 - 2e-06 28.1 0.4 4.7e-06 26.9 0.4 1.7 1 0 0 1 1 1 1 Carbohydrate binding domain Mak10 PF04112.13 ETS61303.1 - 1.5e-58 197.0 0.0 3.4e-58 195.9 0.0 1.6 2 0 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase AraC_N PF06719.13 ETS61304.1 - 0.09 12.4 1.3 2 8.1 0.5 2.7 2 0 0 2 2 2 0 AraC-type transcriptional regulator N-terminus AAA PF00004.29 ETS61305.1 - 1.8e-27 96.3 0.0 3.8e-27 95.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS61305.1 - 3e-10 39.7 0.1 6.9e-10 38.6 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ETS61305.1 - 3.4e-08 33.3 1.8 6.7e-08 32.4 1.8 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 ETS61305.1 - 5.3e-06 26.5 0.0 1.3e-05 25.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETS61305.1 - 6.1e-06 26.7 0.1 4.8e-05 23.8 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ETS61305.1 - 0.00011 21.9 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ETS61305.1 - 0.00012 22.2 0.0 0.00025 21.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ETS61305.1 - 0.0011 19.5 0.0 0.021 15.4 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETS61305.1 - 0.0012 19.2 0.4 0.0069 16.7 0.0 2.4 2 1 1 3 3 3 1 AAA domain TIP49 PF06068.13 ETS61305.1 - 0.0012 18.2 0.0 0.0027 17.0 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ETS61305.1 - 0.0015 18.7 0.0 0.0032 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETS61305.1 - 0.002 17.9 0.0 0.0042 16.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_28 PF13521.6 ETS61305.1 - 0.0063 16.8 0.2 0.019 15.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETS61305.1 - 0.0065 15.9 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF2072 PF09845.9 ETS61305.1 - 0.0071 16.6 0.1 0.013 15.7 0.1 1.4 1 0 0 1 1 1 1 Zn-ribbon containing protein AAA_3 PF07726.11 ETS61305.1 - 0.0083 16.0 0.0 0.016 15.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ETS61305.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 ETS61305.1 - 0.02 14.3 0.0 0.04 13.3 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF815 PF05673.13 ETS61305.1 - 0.027 13.6 0.0 0.05 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 ETS61305.1 - 0.032 13.9 0.0 0.1 12.3 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 ETS61305.1 - 0.037 13.5 0.0 0.064 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TMF_TATA_bd PF12325.8 ETS61305.1 - 0.045 14.0 0.6 0.086 13.1 0.2 1.7 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding RNA_helicase PF00910.22 ETS61305.1 - 0.046 14.1 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 ETS61305.1 - 0.047 13.4 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 ETS61305.1 - 0.047 12.8 0.0 0.097 11.7 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 ETS61305.1 - 0.055 13.5 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETS61305.1 - 0.058 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_11 PF13086.6 ETS61305.1 - 0.064 13.0 0.1 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETS61305.1 - 0.066 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain RILP PF11461.8 ETS61305.1 - 0.069 13.4 1.0 0.13 12.5 1.0 1.5 1 0 0 1 1 1 0 Rab interacting lysosomal protein Zeta_toxin PF06414.12 ETS61305.1 - 0.085 12.1 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 ETS61305.1 - 0.13 11.9 0.6 0.55 9.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETS61305.1 - 0.14 12.5 0.2 0.42 10.9 0.0 1.8 2 1 0 2 2 1 0 AAA domain Fe-S_biosyn PF01521.20 ETS61306.1 - 2.4e-17 63.1 0.0 3.2e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DEAD PF00270.29 ETS61307.1 - 5.4e-20 71.9 0.0 1.1e-19 70.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS61307.1 - 0.00023 21.5 0.0 0.0004 20.7 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Carboxyl_trans PF01039.22 ETS61308.1 - 3.5e-106 355.8 0.0 4.3e-106 355.5 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MFS_1 PF07690.16 ETS61309.1 - 1.3e-39 136.2 45.6 1.3e-39 136.2 45.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 ETS61309.1 - 3.3e-06 26.7 7.1 3.3e-06 26.7 7.1 1.8 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DUF1129 PF06570.11 ETS61309.1 - 0.2 11.1 8.2 0.21 11.0 1.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) CoA_transf_3 PF02515.17 ETS61310.1 - 1.7e-43 149.2 0.0 4.5e-35 121.4 0.0 2.3 2 1 0 2 2 2 2 CoA-transferase family III Auxin_canalis PF05703.11 ETS61310.1 - 0.09 12.7 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Auxin canalisation CPSase_L_D2 PF02786.17 ETS61311.1 - 1.7e-58 197.6 0.0 2.8e-58 196.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ETS61311.1 - 3.8e-37 127.2 0.6 8.8e-37 126.0 0.1 1.9 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ETS61311.1 - 4.7e-29 100.7 0.0 1.2e-28 99.3 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 ETS61311.1 - 4.9e-11 42.5 0.0 9.1e-11 41.7 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl PF00364.22 ETS61311.1 - 1.3e-10 41.0 0.0 2.8e-10 39.9 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ETS61311.1 - 2.8e-06 27.0 0.2 0.02 14.7 0.0 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 ETS61311.1 - 4.9e-06 26.2 0.0 1.1e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ETS61311.1 - 5.1e-06 26.6 0.0 9.5e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 ETS61311.1 - 0.091 12.3 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain Peptidase_S9 PF00326.21 ETS61312.1 - 1.1e-08 34.8 0.1 1.3e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ETS61312.1 - 1.2e-07 31.2 1.1 4.2e-05 22.9 0.2 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS61312.1 - 2.2e-06 27.5 0.8 0.0011 18.7 0.4 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF1749 PF08538.10 ETS61312.1 - 3.5e-05 23.1 0.1 7.6e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1749) SNF2_N PF00176.23 ETS61314.1 - 7.9e-10 38.0 0.0 1.4e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETS61314.1 - 4.9e-06 26.7 0.0 8.7e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETS61314.1 - 2.7e-05 24.5 0.0 6.9e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TFX_C PF14601.6 ETS61314.1 - 0.1 12.6 0.1 0.34 10.9 0.1 1.8 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term SNF2_N PF00176.23 ETS61315.1 - 3.7e-08 32.5 0.0 9.2e-08 31.2 0.0 1.6 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS61315.1 - 4.4e-06 27.0 0.0 1e-05 25.8 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS61315.1 - 1.6e-05 25.0 0.0 3.2e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PBP1_TM PF14812.6 ETS61315.1 - 0.52 10.7 3.8 2.6 8.5 3.8 2.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SNF2_N PF00176.23 ETS61316.1 - 4e-08 32.4 0.0 7.4e-08 31.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS61316.1 - 1e-07 32.3 0.0 3.1e-07 30.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS61316.1 - 1.1e-06 28.8 0.0 4.1e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit TnpV PF14198.6 ETS61316.1 - 0.0015 18.5 0.4 0.79 9.7 0.3 3.0 2 0 0 2 2 2 2 Transposon-encoded protein TnpV HK97-gp10_like PF04883.12 ETS61316.1 - 0.015 16.3 0.1 0.074 14.0 0.1 2.2 1 0 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component RsbRD_N PF14361.6 ETS61316.1 - 0.12 13.1 1.4 1.1 10.0 0.2 3.1 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Peptidase_C48 PF02902.19 ETS61318.1 - 1.8e-15 57.4 0.5 3.6e-15 56.4 0.0 1.6 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain zf-NOSIP PF15906.5 ETS61318.1 - 0.1 12.7 0.0 0.48 10.6 0.0 2.0 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein DUF3145 PF11343.8 ETS61319.1 - 0.094 12.3 0.1 18 4.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3145) Epimerase PF01370.21 ETS61320.1 - 1.7e-13 50.6 0.0 2.6e-13 50.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETS61320.1 - 2.1e-11 43.5 0.0 1.1e-09 37.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 ETS61320.1 - 5.4e-11 42.0 0.0 2.5e-10 39.9 0.0 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ETS61320.1 - 1e-06 28.4 0.0 1.4e-06 28.0 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ETS61320.1 - 6.5e-06 26.2 0.1 9.4e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ETS61320.1 - 0.0058 16.2 0.0 0.012 15.2 0.0 1.5 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ETS61321.1 - 4.8e-05 22.9 0.0 0.00067 19.2 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ETS61321.1 - 0.0041 17.5 0.0 0.088 13.2 0.0 2.2 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 ETS61321.1 - 0.0094 15.5 0.0 0.038 13.5 0.0 1.9 2 0 0 2 2 2 1 Glucose dehydrogenase C-terminus Abhydrolase_1 PF00561.20 ETS61322.1 - 3.7e-07 30.0 0.0 7.7e-07 29.0 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS61322.1 - 6.9e-07 28.8 0.0 0.00019 20.8 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 ETS61322.1 - 1.3e-06 28.1 0.0 4.7e-06 26.3 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ETS61322.1 - 6.6e-05 22.5 0.0 0.001 18.6 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ETS61322.1 - 9.1e-05 22.2 0.0 0.0001 22.0 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 ETS61322.1 - 0.00083 20.0 0.3 0.0011 19.6 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family BAAT_C PF08840.11 ETS61322.1 - 0.02 14.8 0.0 0.06 13.3 0.0 1.8 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal AXE1 PF05448.12 ETS61322.1 - 0.037 12.7 0.1 0.11 11.1 0.1 1.7 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) PRCH PF03967.13 ETS61323.1 - 0.0026 18.0 0.2 0.0047 17.2 0.2 1.3 1 0 0 1 1 1 1 Photosynthetic reaction centre, H-chain N-terminal region Lactamase_B PF00753.27 ETS61324.1 - 4.4e-06 26.8 2.6 8.8e-06 25.9 2.6 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETS61324.1 - 0.0026 17.3 0.0 0.0046 16.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain 2OG-FeII_Oxy_2 PF13532.6 ETS61325.1 - 3.5e-10 40.4 0.0 6e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P22_Tail-4 PF11650.8 ETS61325.1 - 0.064 13.2 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 P22 tail accessory factor Pribosyltran PF00156.27 ETS61326.1 - 0.00014 21.4 0.0 0.00032 20.3 0.0 1.5 1 1 0 1 1 1 1 Phosphoribosyl transferase domain EC042_2821 PF18740.1 ETS61326.1 - 0.19 11.6 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 EC042_2821-lke REase Vps51 PF08700.11 ETS61327.1 - 6.2e-17 61.5 0.0 1.1e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 ETS61327.1 - 0.13 10.9 0.1 0.18 10.4 0.1 1.1 1 0 0 1 1 1 0 Dor1-like family COG5 PF10392.9 ETS61327.1 - 0.17 12.1 1.8 0.28 11.3 1.8 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Usp PF00582.26 ETS61328.1 - 2e-23 83.5 0.5 2e-23 83.5 0.5 3.2 3 0 0 3 3 3 1 Universal stress protein family THOC2_N PF16134.5 ETS61330.1 - 1.8e-168 562.1 0.0 1.8e-168 562.1 0.0 2.6 3 0 0 3 3 3 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 ETS61330.1 - 4.3e-94 315.1 0.0 4.3e-94 315.1 0.0 1.6 2 0 0 2 2 2 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 ETS61330.1 - 2.7e-31 107.5 0.1 9.2e-31 105.7 0.1 2.0 1 0 0 1 1 1 1 Transcription- and export-related complex subunit RhoGEF PF00621.20 ETS61331.1 - 1.3e-30 107.0 0.0 2.3e-30 106.2 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain RRM_1 PF00076.22 ETS61332.1 - 1.5e-33 114.4 5.8 1.4e-18 66.5 0.0 2.6 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS61332.1 - 0.0012 18.4 0.0 0.09 12.4 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ETS61332.1 - 0.025 14.7 1.0 0.18 11.9 0.0 2.5 2 1 0 2 2 2 0 Limkain b1 RRM_7 PF16367.5 ETS61332.1 - 0.048 13.8 0.1 5.5 7.2 0.0 2.9 2 2 0 2 2 2 0 RNA recognition motif GREB1 PF15782.5 ETS61332.1 - 3.3 4.7 4.7 4.2 4.4 4.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PHM7_cyt PF14703.6 ETS61332.1 - 4.1 7.6 10.3 0.39 10.9 0.2 3.0 2 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter LtrA PF06772.11 ETS61333.1 - 3.7e-18 65.9 22.6 3.7e-18 65.9 22.6 2.8 2 1 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) RabGAP-TBC PF00566.18 ETS61334.1 - 1.6e-51 175.1 0.0 2.7e-51 174.3 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ABC2_membrane PF01061.24 ETS61335.1 - 3.3e-74 248.8 53.1 3.6e-40 137.6 23.0 3.0 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 ETS61335.1 - 3.2e-36 124.9 0.4 9.6e-18 65.0 0.0 3.5 4 0 0 4 4 3 2 ABC transporter PDR_CDR PF06422.12 ETS61335.1 - 8e-26 89.8 4.5 1.5e-20 72.9 0.0 3.1 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 ETS61335.1 - 1.1e-09 38.7 2.0 1.6e-09 38.2 0.3 2.2 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_33 PF13671.6 ETS61335.1 - 6.9e-07 29.5 0.7 0.021 15.0 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 ETS61335.1 - 3.1e-05 23.6 0.2 0.02 14.6 0.1 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ETS61335.1 - 4.1e-05 23.5 0.0 0.13 12.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ETS61335.1 - 0.00012 22.5 0.1 0.24 11.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ETS61335.1 - 0.00025 21.0 0.1 0.0039 17.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ETS61335.1 - 0.00083 19.6 0.2 0.88 9.8 0.1 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ETS61335.1 - 0.0011 18.6 0.2 0.044 13.3 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETS61335.1 - 0.0013 19.3 1.0 0.33 11.5 0.0 3.7 4 0 0 4 4 3 1 AAA domain ABC2_membrane_3 PF12698.7 ETS61335.1 - 0.0017 17.5 8.4 0.0017 17.5 8.4 3.7 3 1 0 3 3 3 2 ABC-2 family transporter protein SMC_N PF02463.19 ETS61335.1 - 0.0023 17.4 0.1 0.03 13.8 0.0 2.7 3 1 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 ETS61335.1 - 0.016 15.4 0.3 0.39 10.9 0.1 2.7 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ETS61335.1 - 0.017 15.2 0.6 8.7 6.5 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 ETS61335.1 - 0.018 14.6 1.2 0.67 9.5 0.2 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ETS61335.1 - 0.021 14.7 0.5 4.4 7.2 0.1 2.5 2 0 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 ETS61335.1 - 0.022 14.0 0.4 4.6 6.5 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 ETS61335.1 - 0.031 14.0 0.3 3.9 7.1 0.1 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETS61335.1 - 0.084 13.3 1.0 17 5.8 0.0 3.4 3 0 0 3 3 3 0 RNA helicase FtsK_SpoIIIE PF01580.18 ETS61335.1 - 0.11 11.8 0.0 3.6 6.9 0.0 2.6 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_24 PF13479.6 ETS61335.1 - 0.17 11.6 0.2 15 5.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 ETS61335.1 - 1.9 8.9 7.8 3.1 8.2 0.1 3.5 4 0 0 4 4 4 0 AAA domain DUF1440 PF07274.12 ETS61335.1 - 2.3 8.5 7.9 12 6.2 0.7 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1440) Complex1_LYR PF05347.15 ETS61336.1 - 3.9e-08 33.2 4.4 7e-08 32.4 4.4 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) 2-oxogl_dehyd_N PF16078.5 ETS61336.1 - 0.023 14.3 0.0 0.047 13.3 0.0 1.5 1 0 0 1 1 1 0 2-oxoglutarate dehydrogenase N-terminus HhH-GPD PF00730.25 ETS61338.1 - 3.3e-08 33.9 0.0 4.5e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Palm_thioest PF02089.15 ETS61339.1 - 2.8e-79 266.4 0.0 3.5e-79 266.1 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase FSH1 PF03959.13 ETS61339.1 - 0.022 14.4 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Lipase_2 PF01674.18 ETS61339.1 - 0.023 14.2 0.0 0.53 9.8 0.0 2.1 1 1 0 1 1 1 0 Lipase (class 2) Abhydrolase_1 PF00561.20 ETS61339.1 - 0.044 13.4 0.6 0.16 11.6 0.1 2.2 2 1 0 2 2 2 0 alpha/beta hydrolase fold Clat_adaptor_s PF01217.20 ETS61340.1 - 1.4e-17 64.0 0.1 2.1e-15 56.9 0.1 2.2 1 1 0 1 1 1 1 Clathrin adaptor complex small chain Pkinase PF00069.25 ETS61341.1 - 1.4e-75 254.1 0.0 1.8e-75 253.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61341.1 - 1.6e-44 152.2 0.0 2.2e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS61341.1 - 7.1e-12 45.2 0.0 1.1e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETS61341.1 - 0.0046 16.3 0.1 0.024 14.0 0.1 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETS61341.1 - 0.0073 15.3 0.1 0.012 14.5 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain RabGAP-TBC PF00566.18 ETS61342.1 - 3.2e-20 72.7 0.4 5.4e-16 58.9 0.5 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain NPA PF16469.5 ETS61342.1 - 0.19 12.3 0.1 0.55 10.8 0.1 1.7 1 1 0 1 1 1 0 Nematode polyprotein allergen ABA-1 Sporozoite_P67 PF05642.11 ETS61342.1 - 4.8 5.1 15.5 6.9 4.6 15.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MFS_1 PF07690.16 ETS61344.1 - 9.1e-26 90.6 32.6 1.2e-25 90.2 32.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61344.1 - 0.71 8.7 25.1 1.4 7.7 21.1 2.6 1 1 0 1 1 1 0 Sugar (and other) transporter NifU_N PF01592.16 ETS61349.1 - 5.5e-54 181.7 0.5 8.3e-54 181.2 0.1 1.5 2 0 0 2 2 2 1 NifU-like N terminal domain Ribosomal_L11 PF00298.19 ETS61350.1 - 6.5e-26 90.6 2.0 1e-25 90.0 2.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 ETS61350.1 - 6.5e-23 80.4 0.8 1.7e-22 79.0 0.8 1.7 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Proteasome PF00227.26 ETS61351.1 - 2e-60 203.5 0.0 4.6e-60 202.4 0.0 1.5 2 0 0 2 2 2 1 Proteasome subunit Proteasome_A_N PF10584.9 ETS61351.1 - 2e-09 36.9 0.0 7.5e-09 35.1 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RabGAP-TBC PF00566.18 ETS61352.1 - 4.6e-16 59.1 0.0 8.6e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Ras PF00071.22 ETS61353.1 - 4.1e-46 156.5 0.6 4.9e-46 156.3 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61353.1 - 8.5e-16 58.3 0.0 1.2e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61353.1 - 1.3e-06 28.0 0.0 1.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS61353.1 - 5.5e-05 23.2 0.0 7.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS61353.1 - 0.0012 18.4 0.4 0.0047 16.5 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETS61353.1 - 0.0019 17.7 0.1 0.0027 17.2 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETS61353.1 - 0.0046 16.9 0.1 1.4 8.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ETS61353.1 - 0.009 15.5 0.1 0.11 12.0 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B Rpr2 PF04032.16 ETS61354.1 - 4.4e-12 46.1 0.3 4.4e-12 46.1 0.3 1.9 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4874 PF16173.5 ETS61354.1 - 0.041 13.6 0.0 0.075 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) DUF4551 PF15087.6 ETS61354.1 - 0.21 10.4 1.5 0.26 10.1 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Glyco_hydro_cc PF11790.8 ETS61355.1 - 5.9e-58 196.3 10.2 8.7e-58 195.7 10.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core DUF4253 PF14062.6 ETS61355.1 - 0.0012 19.0 0.0 0.0028 17.8 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4253) Macoilin PF09726.9 ETS61355.1 - 0.051 12.1 8.2 0.063 11.8 8.2 1.2 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 ETS61355.1 - 0.059 12.2 5.4 0.07 12.0 5.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4897 PF16238.5 ETS61355.1 - 0.097 12.5 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4897) SR-25 PF10500.9 ETS61355.1 - 0.64 9.6 30.9 1.1 8.8 30.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 ETS61355.1 - 1.2 7.9 7.4 2 7.1 7.4 1.3 1 0 0 1 1 1 0 Presenilin DUF4692 PF15763.5 ETS61355.1 - 1.9 8.9 15.8 4 7.9 15.8 1.5 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) AF-4 PF05110.13 ETS61355.1 - 2.3 6.2 28.6 3.6 5.6 28.6 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pol_alpha_B_N PF08418.10 ETS61355.1 - 7.5 6.4 12.6 21 5.0 6.9 2.6 3 0 0 3 3 3 0 DNA polymerase alpha subunit B N-terminal XRCC4 PF06632.12 ETS61355.1 - 9.3 5.0 8.4 16 4.2 8.4 1.3 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Peptidase_C13 PF01650.18 ETS61357.1 - 9.5e-40 136.7 0.0 1.3e-39 136.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 ETS61357.1 - 0.067 13.5 0.0 0.15 12.3 0.0 1.6 1 0 0 1 1 1 0 Mid domain of argonaute 3HBOH PF10605.9 ETS61357.1 - 0.11 10.7 0.3 0.73 8.0 0.3 1.9 2 0 0 2 2 2 0 3HB-oligomer hydrolase (3HBOH) DUF4447 PF14590.6 ETS61357.1 - 0.16 11.8 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4447) RRM_1 PF00076.22 ETS61358.1 - 2.2e-27 94.7 0.0 5.3e-15 55.0 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ETS61358.1 - 0.0026 17.8 1.1 0.49 10.5 0.0 2.6 3 0 0 3 3 3 2 Limkain b1 RRM_3 PF08777.11 ETS61358.1 - 0.0031 17.5 0.0 0.43 10.6 0.0 2.1 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 ETS61358.1 - 0.027 14.6 0.0 0.12 12.5 0.0 2.0 1 1 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 ETS61358.1 - 0.11 12.5 0.0 0.69 10.0 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif SH3_1 PF00018.28 ETS61359.1 - 3.9e-23 80.8 0.0 2.5e-10 39.8 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ETS61359.1 - 1.1e-13 50.6 0.0 5.9e-09 35.5 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 ETS61359.1 - 8.2e-13 48.0 0.0 2.5e-05 24.0 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 ETS61359.1 - 6.2e-09 35.8 0.0 2.1e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 PX domain Adap_comp_sub PF00928.21 ETS61360.1 - 1e-41 143.1 0.0 1.5e-41 142.6 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETS61360.1 - 0.0023 17.9 0.0 0.004 17.1 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DNA_RNApol_7kD PF03604.13 ETS61361.1 - 2.3e-16 59.1 6.3 3.4e-16 58.6 6.3 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Zn-ribbon_8 PF09723.10 ETS61361.1 - 0.022 14.8 1.8 0.044 13.9 1.8 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Anti-TRAP PF15777.5 ETS61361.1 - 0.034 14.1 0.1 0.055 13.4 0.1 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf-ISL3 PF14690.6 ETS61361.1 - 0.048 14.3 0.3 0.048 14.3 0.3 1.7 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 BOP1NT PF08145.12 ETS61362.1 - 2.2e-106 355.5 3.5 3.5e-106 354.9 3.5 1.3 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 ETS61362.1 - 3.8e-21 75.0 10.9 1.9e-07 31.7 0.4 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS61362.1 - 1.6e-05 25.1 0.4 0.062 13.6 0.0 4.8 2 2 3 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Actin PF00022.19 ETS61363.1 - 1.4e-115 386.2 0.0 2.2e-115 385.5 0.0 1.3 1 1 0 1 1 1 1 Actin adh_short_C2 PF13561.6 ETS61364.1 - 6.2e-56 189.6 0.4 7.8e-56 189.2 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS61364.1 - 2e-45 154.6 3.0 2.7e-45 154.2 3.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS61364.1 - 1e-16 61.4 0.7 2.7e-16 60.0 0.5 1.7 2 0 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 ETS61364.1 - 5.5e-05 22.7 0.1 7.3e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETS61364.1 - 0.00098 18.6 0.5 0.0018 17.8 0.5 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family SBP_bac_5 PF00496.22 ETS61364.1 - 0.0035 16.3 0.1 0.0044 16.0 0.1 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 5 Middle Polysacc_synt_2 PF02719.15 ETS61364.1 - 0.0039 16.4 0.4 0.0059 15.8 0.4 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3HCDH_N PF02737.18 ETS61364.1 - 0.0075 16.2 0.5 0.84 9.5 0.7 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ETS61364.1 - 0.036 14.3 0.2 0.063 13.5 0.2 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ETS61364.1 - 0.068 13.8 0.7 22 5.7 0.0 2.8 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent Rot1 PF10681.9 ETS61366.1 - 8.1e-45 152.9 0.1 1e-44 152.6 0.1 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal FixS PF03597.15 ETS61366.1 - 0.17 11.6 1.2 0.36 10.6 1.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type SKN1 PF03935.15 ETS61367.1 - 1.4e-196 653.8 0.6 1.8e-196 653.4 0.6 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 ETS61367.1 - 4.2e-05 23.1 0.1 0.069 12.6 0.0 3.0 2 1 0 2 2 2 2 Glycosyl hydrolases family 16 ODV-E18 PF10717.9 ETS61367.1 - 2.4 8.1 4.3 22 5.0 0.2 2.7 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DAO PF01266.24 ETS61369.1 - 4.9e-23 82.3 0.2 8.3e-22 78.2 0.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETS61369.1 - 0.0022 18.5 0.0 0.0048 17.4 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS61369.1 - 0.0036 16.4 0.0 0.0055 15.8 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS61369.1 - 0.0044 16.3 0.1 0.035 13.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS61369.1 - 0.0072 16.5 0.1 0.016 15.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETS61369.1 - 0.047 12.9 0.0 0.19 11.0 0.0 1.8 2 0 0 2 2 2 0 Thi4 family NAD_binding_7 PF13241.6 ETS61369.1 - 0.12 12.9 0.0 0.32 11.5 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ETS61369.1 - 0.12 11.6 0.0 0.4 9.9 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain ApbA PF02558.16 ETS61369.1 - 0.14 11.8 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 ETS61369.1 - 0.22 11.4 0.1 0.92 9.4 0.0 2.0 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2OG-FeII_Oxy PF03171.20 ETS61370.1 - 2.3e-23 82.6 0.0 4e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ETS61370.1 - 1.7e-18 67.4 0.0 2.9e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal PMP1_2 PF08114.11 ETS61371.1 - 0.00095 18.9 0.5 0.0016 18.1 0.5 1.3 1 0 0 1 1 1 1 ATPase proteolipid family DUF262 PF03235.14 ETS61372.1 - 1.7e-13 51.3 0.0 3.4e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF262 DUF1378 PF07125.11 ETS61372.1 - 0.14 12.3 0.2 0.49 10.6 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1378) DUF1748 PF08520.10 ETS61373.1 - 1.2e-25 89.2 0.0 1.9e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Pkinase PF00069.25 ETS61374.1 - 8.5e-74 248.2 0.0 1.1e-73 247.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61374.1 - 1e-30 106.9 0.0 1.6e-22 80.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS61374.1 - 1.7e-11 44.0 0.1 0.011 15.0 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 ETS61374.1 - 0.0019 17.1 0.0 0.004 16.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETS61374.1 - 0.053 12.9 0.0 0.095 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETS61374.1 - 0.15 12.0 0.0 1.2 8.9 0.0 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family Sedlin_N PF04628.13 ETS61375.1 - 2.1e-31 108.8 0.0 6.5e-28 97.5 0.0 2.1 2 0 0 2 2 2 2 Sedlin, N-terminal conserved region Sybindin PF04099.12 ETS61375.1 - 0.00018 21.5 0.0 0.00031 20.7 0.0 1.5 1 0 0 1 1 1 1 Sybindin-like family Avl9 PF09794.9 ETS61375.1 - 0.11 11.2 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Transport protein Avl9 DUF508 PF04370.12 ETS61375.1 - 0.24 11.1 0.1 0.24 11.1 0.1 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF508) Herpes_capsid PF06112.11 ETS61375.1 - 6.9 6.7 20.9 11 6.1 20.9 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein bZIP_1 PF00170.21 ETS61376.1 - 8.4e-08 32.2 17.2 1.6e-07 31.3 17.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ETS61376.1 - 0.01 15.9 24.1 0.14 12.3 12.7 2.5 1 1 1 2 2 2 0 Basic region leucine zipper DNA_Packaging_2 PF11123.8 ETS61376.1 - 0.014 15.6 0.1 0.03 14.5 0.1 1.5 1 0 0 1 1 1 0 DNA packaging protein eIF3_subunit PF08597.10 ETS61376.1 - 0.017 15.1 1.9 0.025 14.5 1.9 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit bZIP_Maf PF03131.17 ETS61376.1 - 0.09 13.3 18.6 0.32 11.5 18.6 1.9 1 1 0 1 1 1 0 bZIP Maf transcription factor FlaC_arch PF05377.11 ETS61376.1 - 0.14 12.6 0.5 0.33 11.4 0.5 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 ETS61376.1 - 0.29 11.1 11.9 0.2 11.7 6.5 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETS61376.1 - 0.36 9.6 8.8 0.5 9.2 8.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF16 PF01519.16 ETS61376.1 - 0.4 11.2 3.3 0.58 10.7 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 SHE3 PF17078.5 ETS61376.1 - 0.57 9.9 7.4 0.78 9.4 7.4 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Uso1_p115_C PF04871.13 ETS61376.1 - 0.92 9.9 8.3 1.5 9.2 8.3 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF724 PF05266.14 ETS61376.1 - 1.5 8.6 7.3 2 8.2 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4239 PF14023.6 ETS61376.1 - 1.7 8.4 3.3 2.3 7.9 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) UPF0242 PF06785.11 ETS61376.1 - 2.1 8.4 8.5 3 7.9 8.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FUSC PF04632.12 ETS61376.1 - 3 6.2 5.2 3.1 6.2 5.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family GTP_EFTU PF00009.27 ETS61377.1 - 5.1e-45 153.4 0.0 8e-45 152.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETS61377.1 - 2.6e-34 117.9 0.0 2.6e-34 117.9 0.0 2.4 4 0 0 4 4 4 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETS61377.1 - 2.9e-10 40.4 0.8 6.6e-10 39.2 0.8 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETS61377.1 - 0.0014 18.7 0.0 0.0056 16.7 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 ETS61377.1 - 0.09 12.7 0.3 0.3 11.0 0.3 1.9 1 0 0 1 1 1 0 Elongation factor Tu domain 4 DAD PF02109.16 ETS61378.1 - 5.7e-47 158.5 1.2 6.6e-47 158.3 1.2 1.0 1 0 0 1 1 1 1 DAD family Rho_GDI PF02115.17 ETS61379.1 - 6.4e-68 228.3 0.0 9.2e-68 227.9 0.0 1.2 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor DUF1640 PF07798.11 ETS61380.1 - 1.6e-60 204.1 3.5 2.7e-60 203.4 3.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) UbiA PF01040.18 ETS61380.1 - 1.3e-52 178.7 26.6 2.6e-52 177.6 26.6 1.5 1 0 0 1 1 1 1 UbiA prenyltransferase family TauD PF02668.16 ETS61380.1 - 2e-50 172.1 1.3 6.5e-50 170.4 1.3 1.9 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Cu_amine_oxidN1 PF07833.11 ETS61380.1 - 0.022 15.2 0.1 0.05 14.1 0.1 1.6 1 0 0 1 1 1 0 Copper amine oxidase N-terminal domain DUF971 PF06155.12 ETS61380.1 - 0.14 12.9 0.0 0.4 11.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF971) DUF4404 PF14357.6 ETS61380.1 - 3.7 8.2 6.6 17 6.1 6.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) DUF3564 PF12087.8 ETS61381.1 - 0.0095 15.9 0.1 0.016 15.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3564) CNDH2_M PF16869.5 ETS61381.1 - 0.1 13.3 2.3 0.1 13.3 0.5 1.7 1 1 0 2 2 2 0 PF16858 HTH_31 PF13560.6 ETS61381.1 - 0.26 11.7 5.6 0.15 12.4 3.2 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain Pyr_redox_2 PF07992.14 ETS61384.1 - 1.4e-35 122.9 0.3 1.3e-34 119.8 0.3 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS61384.1 - 1.3e-14 54.5 0.3 1.9e-10 41.1 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS61384.1 - 3.7e-06 26.4 0.0 6.3e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS61384.1 - 1.4e-05 24.9 0.8 0.023 14.3 0.4 3.1 3 0 0 3 3 3 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ETS61384.1 - 0.00091 18.5 0.8 0.0017 17.6 0.1 1.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 ETS61384.1 - 0.0011 19.4 0.0 0.56 10.7 0.0 2.5 2 0 0 2 2 2 2 Putative NAD(P)-binding Trp_halogenase PF04820.14 ETS61384.1 - 0.0011 17.9 0.7 0.34 9.7 0.2 3.1 3 0 0 3 3 3 1 Tryptophan halogenase NAD_binding_9 PF13454.6 ETS61384.1 - 0.0059 16.6 4.9 2.3 8.2 0.0 4.2 3 1 1 4 4 4 1 FAD-NAD(P)-binding TrkA_N PF02254.18 ETS61384.1 - 0.0067 16.7 0.0 3.9 7.8 0.1 2.6 2 0 0 2 2 2 2 TrkA-N domain ApbA PF02558.16 ETS61384.1 - 0.054 13.1 0.2 0.4 10.3 0.1 2.4 2 1 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_ring PF18669.1 ETS61384.1 - 0.088 13.0 0.3 0.32 11.2 0.3 2.0 2 0 0 2 2 2 0 Trimeric autotransporter adhesin Trp ring domain DNA_processg_A PF02481.15 ETS61384.1 - 0.23 10.7 1.4 0.42 9.8 0.2 2.0 2 0 0 2 2 2 0 DNA recombination-mediator protein A SRPRB PF09439.10 ETS61385.1 - 2.1e-12 46.9 0.1 5e-12 45.6 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ETS61385.1 - 3.1e-07 30.0 0.0 4.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS61385.1 - 2.5e-05 24.3 0.0 4.7e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS61385.1 - 4e-05 23.2 0.2 0.0056 16.2 0.0 2.3 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 ETS61385.1 - 0.0018 18.5 0.0 0.0036 17.5 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETS61385.1 - 0.2 11.2 0.0 0.37 10.4 0.0 1.4 1 0 0 1 1 1 0 Ras family Proteasome PF00227.26 ETS61386.1 - 4e-46 156.9 0.0 5e-46 156.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ETS61386.1 - 6.4e-13 48.1 0.1 1.2e-12 47.3 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature DUF883 PF05957.13 ETS61387.1 - 4.8e-05 23.9 29.2 0.0041 17.7 1.4 3.6 1 1 1 3 3 3 3 Bacterial protein of unknown function (DUF883) Apolipoprotein PF01442.18 ETS61387.1 - 0.17 11.8 27.7 0.45 10.4 27.7 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain YtxH PF12732.7 ETS61387.1 - 0.96 10.0 39.9 25 5.5 4.9 4.1 1 1 2 3 3 3 0 YtxH-like protein DBINO PF13892.6 ETS61387.1 - 0.99 9.8 24.7 0.23 11.8 14.3 2.3 1 1 1 2 2 2 0 DNA-binding domain SART-1 PF03343.13 ETS61388.1 - 3.5e-167 557.7 59.0 4.4e-167 557.4 59.0 1.1 1 0 0 1 1 1 1 SART-1 family FSA_C PF10479.9 ETS61388.1 - 1.8 6.6 3.7 3.7 5.6 3.7 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PQ-loop PF04193.14 ETS61389.1 - 4.4e-33 112.9 0.8 3.6e-17 61.9 0.1 2.4 2 0 0 2 2 2 2 PQ loop repeat DUF2279 PF10043.9 ETS61389.1 - 0.032 15.0 0.2 15 6.4 0.0 2.8 2 1 1 3 3 3 0 Predicted periplasmic lipoprotein (DUF2279) ER_lumen_recept PF00810.18 ETS61389.1 - 0.038 14.8 1.5 7.4 7.4 0.8 2.4 1 1 1 2 2 2 0 ER lumen protein retaining receptor UPF0113_N PF17833.1 ETS61390.1 - 4.9e-30 103.9 0.0 7.6e-30 103.3 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 ETS61390.1 - 2e-24 85.7 0.0 3e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PP1 PF07430.11 ETS61390.1 - 0.067 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Phloem filament protein PP1 cystatin-like domain Utp14 PF04615.13 ETS61391.1 - 7.6e-193 643.1 54.4 7.6e-193 643.1 54.4 2.2 1 1 0 2 2 2 1 Utp14 protein Tho2 PF11262.8 ETS61391.1 - 5.4 6.1 8.8 10 5.2 8.8 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 RhoGAP PF00620.27 ETS61392.1 - 3.1e-25 88.8 0.0 5.1e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Peptidase_M23 PF01551.22 ETS61393.1 - 0.025 14.8 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M23 Y_phosphatase PF00102.27 ETS61394.1 - 3.6e-39 134.7 0.0 4.7e-39 134.3 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ETS61394.1 - 0.0067 16.2 0.9 0.016 15.0 0.7 1.7 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain HofP PF10748.9 ETS61394.1 - 0.18 11.4 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 DNA utilization proteins HofP DSBA PF01323.20 ETS61395.1 - 7e-30 104.3 0.1 7.9e-30 104.1 0.1 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain DUF4164 PF13747.6 ETS61395.1 - 0.068 13.4 0.1 0.1 12.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Herpes_BLRF2 PF05812.12 ETS61395.1 - 0.22 11.7 1.2 0.31 11.2 0.4 1.6 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein HpcH_HpaI PF03328.14 ETS61396.1 - 7.9e-43 146.1 0.2 1.1e-42 145.7 0.2 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 ETS61396.1 - 3.7e-11 42.8 0.3 0.0002 20.7 0.1 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Aminotran_1_2 PF00155.21 ETS61397.1 - 3.1e-48 164.8 0.0 4.8e-48 164.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETS61397.1 - 0.031 13.6 0.0 0.041 13.2 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase PIG-L PF02585.17 ETS61397.1 - 0.045 14.4 0.0 0.27 11.9 0.0 2.3 3 0 0 3 3 3 0 GlcNAc-PI de-N-acetylase PQ-loop PF04193.14 ETS61398.1 - 1.6e-21 75.8 7.6 8.2e-15 54.3 0.1 3.2 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 ETS61398.1 - 0.00025 21.9 3.4 0.034 15.0 0.4 2.4 3 0 0 3 3 3 2 ER lumen protein retaining receptor Pex24p PF06398.11 ETS61398.1 - 0.15 11.0 0.0 0.34 9.8 0.0 1.6 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin Endonuclease_NS PF01223.23 ETS61399.1 - 5.9e-55 186.5 0.0 4.2e-54 183.8 0.0 1.9 1 1 0 1 1 1 1 DNA/RNA non-specific endonuclease E1_dh PF00676.20 ETS61400.1 - 3e-89 298.9 0.1 3.7e-89 298.6 0.1 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ETS61400.1 - 0.0076 15.5 0.0 0.02 14.1 0.0 1.6 2 0 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Aminotran_3 PF00202.21 ETS61402.1 - 7.7e-91 304.8 0.0 1.4e-90 303.9 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-III Pox_I6 PF04595.13 ETS61402.1 - 0.2 10.6 0.0 0.3 10.0 0.0 1.1 1 0 0 1 1 1 0 Poxvirus I6-like family GFO_IDH_MocA PF01408.22 ETS61403.1 - 2.5e-18 67.0 0.1 4.2e-18 66.3 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ETS61403.1 - 0.0013 19.4 0.0 0.0023 18.6 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 ETS61403.1 - 0.018 15.8 0.2 0.051 14.3 0.0 1.8 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Pex19 PF04614.12 ETS61404.1 - 1.5e-66 224.7 1.4 1.5e-66 224.7 1.4 1.8 2 0 0 2 2 2 1 Pex19 protein family RasGAP_C PF03836.15 ETS61405.1 - 2.5e-48 163.7 4.8 7.9e-48 162.1 4.8 2.0 1 0 0 1 1 1 1 RasGAP C-terminus RasGAP PF00616.19 ETS61405.1 - 8.9e-48 162.8 0.1 3.2e-47 160.9 0.0 2.0 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase IQ PF00612.27 ETS61405.1 - 1.3e-24 83.6 42.6 0.011 15.4 0.4 12.5 12 0 0 12 12 12 10 IQ calmodulin-binding motif CH PF00307.31 ETS61405.1 - 1.5e-16 60.6 0.0 4.5e-16 59.0 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain Big_1 PF02369.16 ETS61405.1 - 0.2 11.7 0.2 0.42 10.7 0.2 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) Glyco_hyd_65N_2 PF14498.6 ETS61405.1 - 0.43 10.4 3.6 2.5 7.9 0.3 2.8 3 0 0 3 3 3 0 Glycosyl hydrolase family 65, N-terminal domain WW_FCH_linker PF16623.5 ETS61406.1 - 3.5 8.4 6.0 0.39 11.5 0.5 2.2 2 0 0 2 2 2 0 Unstructured linker region between on GAS7 protein Peptidase_M24 PF00557.24 ETS61407.1 - 4.7e-19 68.9 0.4 1.1e-18 67.7 0.3 1.5 1 1 0 1 1 1 1 Metallopeptidase family M24 SH3_2 PF07653.17 ETS61407.1 - 0.0027 17.4 0.0 0.0055 16.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain p450 PF00067.22 ETS61408.1 - 5.4e-75 252.9 0.0 9.8e-59 199.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 Endosulfine PF04667.17 ETS61409.1 - 5.6e-25 87.3 0.1 8.9e-25 86.6 0.1 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Porin_3 PF01459.22 ETS61410.1 - 1.9e-75 253.8 0.9 2.3e-75 253.6 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin Hpt PF01627.23 ETS61412.1 - 1.5e-08 34.8 0.1 2.7e-08 34.0 0.1 1.6 1 1 0 1 1 1 1 Hpt domain Arrestin_C PF02752.22 ETS61413.1 - 9.3e-12 45.6 2.6 1.3e-10 41.8 2.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETS61413.1 - 1.2e-07 31.9 0.2 0.0014 18.7 0.3 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain MG2 PF01835.19 ETS61413.1 - 0.13 12.8 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 MG2 domain LDB19 PF13002.7 ETS61413.1 - 0.15 11.7 0.1 4.2 7.0 0.0 2.2 2 0 0 2 2 2 0 Arrestin_N terminal like DDHD PF02862.17 ETS61414.1 - 3.7e-37 128.7 0.0 3.7e-37 128.7 0.0 3.5 3 1 0 3 3 3 1 DDHD domain MtrF PF09472.10 ETS61414.1 - 0.11 11.9 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) Cupin_8 PF13621.6 ETS61415.1 - 1.8e-22 80.3 0.0 3.2e-22 79.5 0.0 1.4 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ETS61415.1 - 1.2e-07 31.6 0.0 3.7e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 ETS61415.1 - 0.038 14.4 0.0 0.45 10.9 0.0 2.6 2 1 0 2 2 2 0 JmjC domain, hydroxylase Tcp11 PF05794.13 ETS61417.1 - 1.9e-96 323.8 0.0 4.4e-96 322.7 0.0 1.6 1 0 0 1 1 1 1 T-complex protein 11 NIF PF03031.18 ETS61418.1 - 9.7e-55 184.6 0.1 1.4e-54 184.1 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SAGA-Tad1 PF12767.7 ETS61418.1 - 1.7 8.4 5.6 3.4 7.3 5.6 1.5 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit HLH PF00010.26 ETS61419.1 - 4.3e-18 65.0 1.6 9.4e-18 63.9 1.6 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.13 ETS61419.1 - 0.0022 18.1 24.6 0.0022 18.1 24.6 2.2 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit AIP3 PF03915.13 ETS61419.1 - 0.92 8.5 5.9 4.7 6.2 0.1 2.2 2 0 0 2 2 2 0 Actin interacting protein 3 PEMT PF04191.13 ETS61421.1 - 6.6e-34 116.5 3.6 1.5e-33 115.4 3.6 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase Pkinase PF00069.25 ETS61422.1 - 2.3e-62 210.8 0.0 3.7e-61 206.8 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61422.1 - 8.9e-34 116.9 0.0 1.5e-33 116.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HR1 PF02185.16 ETS61422.1 - 2.7e-23 81.8 21.2 2.3e-12 46.8 8.8 2.5 2 0 0 2 2 2 2 Hr1 repeat C1_1 PF00130.22 ETS61422.1 - 6.4e-20 70.8 26.4 3.4e-11 42.9 9.4 2.3 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 ETS61422.1 - 3.4e-08 34.1 0.6 1.8e-07 31.7 0.6 2.4 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 ETS61422.1 - 9.7e-07 29.0 0.1 2e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 ETS61422.1 - 0.0044 16.4 0.0 0.013 14.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ETS61422.1 - 0.028 14.1 0.0 2.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4349 PF14257.6 ETS61422.1 - 1.3 8.4 3.6 3.1 7.2 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Uds1 PF15456.6 ETS61422.1 - 2.8 8.1 11.7 24 5.1 5.8 3.0 2 1 1 3 3 3 0 Up-regulated During Septation RhoGAP PF00620.27 ETS61423.1 - 1.1e-09 38.3 0.0 7.2e-09 35.6 0.0 2.3 2 1 0 2 2 2 1 RhoGAP domain FCH PF00611.23 ETS61423.1 - 0.0025 18.1 0.1 0.009 16.3 0.1 2.0 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain RIO1 PF01163.22 ETS61424.1 - 3.3e-69 232.3 0.0 3.3e-69 232.3 0.0 1.6 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 ETS61424.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain BUD22 PF09073.10 ETS61424.1 - 0.36 10.1 38.0 0.12 11.7 12.3 2.3 2 0 0 2 2 2 0 BUD22 Cwf_Cwc_15 PF04889.12 ETS61424.1 - 0.85 9.3 34.5 0.24 11.1 13.7 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein YL1 PF05764.13 ETS61424.1 - 1.6 8.8 37.3 0.03 14.4 15.7 2.8 2 1 0 2 2 2 0 YL1 nuclear protein Hist_deacetyl PF00850.19 ETS61425.1 - 1.3e-37 130.0 8.7 2.9e-36 125.5 8.7 2.2 1 1 0 1 1 1 1 Histone deacetylase domain TRAP-gamma PF07074.12 ETS61425.1 - 0.029 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF4154 PF13689.6 ETS61426.1 - 0.13 12.5 0.0 36 4.6 0.0 2.8 2 1 0 2 2 2 0 YfiR/HmsC-like PQ-loop PF04193.14 ETS61427.1 - 4.8e-27 93.5 2.9 4.5e-13 48.8 0.1 2.6 3 0 0 3 3 3 2 PQ loop repeat ZYG-11_interact PF05884.12 ETS61427.1 - 0.052 13.0 0.2 0.085 12.3 0.2 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF3537 PF12056.8 ETS61427.1 - 0.073 11.9 0.1 0.11 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) DUF202 PF02656.15 ETS61427.1 - 0.83 10.1 4.5 2 9.0 0.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF202) Ras PF00071.22 ETS61431.1 - 3.6e-57 192.5 0.0 4.2e-57 192.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61431.1 - 3.3e-22 79.0 0.0 4.5e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61431.1 - 3.8e-07 29.7 0.0 5.8e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ETS61431.1 - 0.00077 18.9 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETS61431.1 - 0.22 10.8 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Asp PF00026.23 ETS61433.1 - 1.5e-17 64.0 0.0 7.2e-11 42.1 0.3 2.4 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS61433.1 - 0.018 15.3 1.6 0.018 15.3 1.6 3.7 3 1 0 3 3 3 0 Xylanase inhibitor N-terminal DUF4381 PF14316.6 ETS61433.1 - 0.24 11.7 6.1 0.036 14.3 1.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) zf-C3HC4_3 PF13920.6 ETS61434.1 - 1.6e-08 34.3 16.4 3.2e-08 33.3 16.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MTABC_N PF16185.5 ETS61434.1 - 0.051 13.1 0.9 0.64 9.5 0.1 2.6 3 0 0 3 3 3 0 Mitochondrial ABC-transporter N-terminal five TM region Prok-RING_4 PF14447.6 ETS61434.1 - 4.4 7.2 13.6 10 6.1 13.6 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 ADH_N PF08240.12 ETS61435.1 - 3.7e-31 107.2 0.2 6.9e-31 106.4 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS61435.1 - 1.6e-16 60.5 0.3 3.2e-16 59.5 0.3 1.5 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ETS61435.1 - 0.00055 19.3 0.2 0.00094 18.5 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Glu_dehyd_C PF16912.5 ETS61435.1 - 0.0013 18.2 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 ETS61435.1 - 0.032 14.1 0.3 0.086 12.8 0.3 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-associated TrkA_N PF02254.18 ETS61435.1 - 0.12 12.6 0.1 0.21 11.9 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain ThiF PF00899.21 ETS61436.1 - 1.1e-38 133.0 0.0 2.2e-38 132.0 0.0 1.5 1 1 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 ETS61436.1 - 0.018 15.3 0.2 0.53 10.5 0.2 2.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 ETS61436.1 - 0.035 13.3 0.1 0.058 12.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain ILVD_EDD PF00920.21 ETS61437.1 - 2.3e-197 656.7 0.5 2.4e-195 650.1 0.5 2.0 1 1 0 1 1 1 1 Dehydratase family zf-TFIIB PF13453.6 ETS61437.1 - 0.27 10.6 3.9 12 5.4 0.3 2.8 2 0 0 2 2 2 0 Transcription factor zinc-finger Mucin PF01456.17 ETS61438.1 - 0.05 13.6 19.6 0.069 13.1 19.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Shisa PF13908.6 ETS61438.1 - 0.75 10.0 3.8 1 9.6 3.8 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TFIIA PF03153.13 ETS61438.1 - 1.7 8.5 4.7 2.1 8.3 4.7 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF515 PF04415.12 ETS61438.1 - 8.2 4.7 10.5 11 4.3 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) TMEM208_SND2 PF05620.11 ETS61439.1 - 1e-47 162.1 5.2 1.6e-47 161.4 5.2 1.3 1 1 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 TRIF-NTD PF17798.1 ETS61440.1 - 0.028 14.5 0.1 0.038 14.1 0.1 1.2 1 0 0 1 1 1 0 TRIF N-terminal domain HA2 PF04408.23 ETS61441.1 - 1.2e-20 73.7 0.0 1.2e-20 73.7 0.0 2.9 3 1 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETS61441.1 - 9.3e-19 67.6 0.0 2.4e-18 66.3 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ETS61441.1 - 8.7e-16 58.3 0.0 2.2e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS61441.1 - 3.4e-07 30.2 0.0 7.3e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETS61441.1 - 0.00016 22.0 0.3 0.003 17.8 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ETS61441.1 - 0.00075 19.9 0.1 0.0082 16.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_30 PF13604.6 ETS61441.1 - 0.0009 19.0 0.0 0.0028 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ETS61441.1 - 0.0012 18.0 0.0 0.0025 16.9 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 ETS61441.1 - 0.015 14.9 0.0 0.086 12.5 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 ETS61441.1 - 0.051 14.0 0.1 0.41 11.0 0.0 2.6 1 1 0 1 1 1 0 AAA ATPase domain Atg14 PF10186.9 ETS61442.1 - 2.1e-24 86.2 0.3 3.4e-15 56.0 0.0 2.7 2 2 0 2 2 2 2 Vacuolar sorting 38 and autophagy-related subunit 14 AvrPto PF11592.8 ETS61442.1 - 0.02 14.9 0.0 0.068 13.2 0.0 1.9 1 0 0 1 1 1 0 Central core of the bacterial effector protein AvrPto zf-rbx1 PF12678.7 ETS61443.1 - 9.3e-07 29.0 4.1 2e-06 28.0 4.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETS61443.1 - 4.1e-06 26.8 3.2 5.5e-06 26.3 3.2 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger WD40 PF00400.32 ETS61444.1 - 4.5e-22 77.9 26.1 0.0048 17.7 0.0 10.5 10 0 0 10 10 10 7 WD domain, G-beta repeat CTP_transf_like PF01467.26 ETS61444.1 - 6.6e-08 32.9 0.0 3.9e-07 30.4 0.0 2.2 2 0 0 2 2 2 1 Cytidylyltransferase-like ANAPC4_WD40 PF12894.7 ETS61444.1 - 4.7e-06 26.8 2.1 5.2 7.4 0.0 6.5 6 1 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain ATE_C PF04377.15 ETS61445.1 - 1.1e-47 162.1 0.1 1.6e-47 161.5 0.1 1.3 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 ETS61445.1 - 7.5e-27 93.5 1.0 1.8e-26 92.3 1.0 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus DSS1_SEM1 PF05160.13 ETS61446.1 - 6e-21 74.3 9.3 1e-20 73.5 9.3 1.4 1 1 0 1 1 1 1 DSS1/SEM1 family DUF1681 PF07933.14 ETS61447.1 - 5e-53 178.8 0.0 6e-53 178.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) DUF3712 PF12505.8 ETS61448.1 - 1.2e-33 116.1 0.0 5e-22 78.5 0.0 5.2 5 0 0 5 5 5 3 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ETS61448.1 - 4.3e-05 24.0 0.0 0.099 13.2 0.0 4.6 5 0 0 5 5 5 1 Late embryogenesis abundant protein ANAPC4 PF12896.7 ETS61449.1 - 1.1e-22 80.5 0.0 2.2e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ETF PF01012.21 ETS61450.1 - 4.1e-45 153.9 0.8 6.5e-45 153.2 0.8 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ETS61450.1 - 3.7e-33 113.4 0.3 7.1e-33 112.5 0.3 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain DHH PF01368.20 ETS61451.1 - 0.057 13.7 0.0 0.13 12.5 0.0 1.6 1 1 0 1 1 1 0 DHH family Rdx PF10262.9 ETS61452.1 - 2.5e-13 50.0 0.0 3.6e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Rdx family TMEM135_C_rich PF15982.5 ETS61453.1 - 0.0082 16.8 0.0 0.022 15.4 0.0 1.7 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 EB1 PF03271.17 ETS61455.1 - 4.3e-17 62.1 0.7 7.4e-17 61.3 0.7 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 ETS61455.1 - 0.0001 22.4 0.1 0.00023 21.3 0.1 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 ETS61455.1 - 0.021 15.0 0.1 0.036 14.2 0.1 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein DUF3138 PF11336.8 ETS61455.1 - 0.96 8.0 5.3 0.68 8.5 3.7 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) Homeodomain PF00046.29 ETS61456.1 - 1.1e-11 44.3 1.6 2.5e-11 43.2 1.6 1.6 1 0 0 1 1 1 1 Homeodomain YdaS_antitoxin PF15943.5 ETS61456.1 - 0.015 15.2 0.1 0.031 14.2 0.1 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT SLAC1 PF03595.17 ETS61457.1 - 1.8e-48 165.5 42.2 1.9e-33 116.1 18.4 2.0 1 1 1 2 2 2 2 Voltage-dependent anion channel Mito_carr PF00153.27 ETS61458.1 - 2.2e-31 107.6 4.8 3.2e-15 55.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein NAD_binding_8 PF13450.6 ETS61459.1 - 1.3e-11 44.6 0.0 7.2e-07 29.3 0.0 2.9 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ETS61459.1 - 0.015 15.3 0.5 0.12 12.4 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding Fungal_trans PF04082.18 ETS61460.1 - 7.1e-09 35.1 0.7 1.3e-08 34.2 0.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61460.1 - 0.00096 19.2 10.3 0.0016 18.5 10.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YqjK PF13997.6 ETS61460.1 - 0.11 12.8 0.5 6.9 7.0 0.1 3.4 3 0 0 3 3 3 0 YqjK-like protein Ribophorin_I PF04597.14 ETS61461.1 - 3.5e-120 402.2 0.0 4e-120 402.0 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I CDC45 PF02724.14 ETS61462.1 - 1.7e-214 713.8 0.0 2e-214 713.6 0.0 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF1376 PF07120.11 ETS61462.1 - 0.032 14.6 0.7 3.1 8.2 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1376) YL1 PF05764.13 ETS61462.1 - 0.32 11.1 5.2 0.53 10.4 5.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Spt5_N PF11942.8 ETS61462.1 - 0.54 11.3 7.8 1.5 9.9 7.8 1.7 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal RasGEF PF00617.19 ETS61463.1 - 2.6e-42 145.0 0.0 4.2e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETS61463.1 - 1.2e-06 28.7 0.0 3.4e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Arf PF00025.21 ETS61463.1 - 0.055 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family p450 PF00067.22 ETS61464.1 - 1.3e-66 225.2 0.0 1.8e-66 224.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 PIN_2 PF10130.9 ETS61464.1 - 0.12 12.6 0.0 0.34 11.2 0.0 1.7 1 0 0 1 1 1 0 PIN domain NLRC4_HD PF17889.1 ETS61464.1 - 0.14 12.5 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 NLRC4 helical domain Fungal_trans PF04082.18 ETS61465.1 - 1.8e-09 37.1 0.1 3.1e-09 36.3 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61465.1 - 4e-08 33.3 9.7 7.2e-08 32.4 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acetyltransf_1 PF00583.25 ETS61466.1 - 5.8e-14 52.3 0.0 7.2e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS61466.1 - 1e-11 45.1 0.0 2.9e-11 43.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS61466.1 - 3.4e-11 43.2 0.0 4.9e-11 42.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ETS61466.1 - 1.6e-05 25.6 0.0 2e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ETS61466.1 - 0.00021 21.5 0.0 0.0016 18.6 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETS61466.1 - 0.0012 18.9 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 ETS61466.1 - 0.0019 18.1 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ETS61466.1 - 0.0076 15.9 0.0 0.013 15.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Arrestin_C PF02752.22 ETS61467.1 - 3e-11 43.9 0.1 1e-08 35.7 0.1 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain DUF3304 PF11745.8 ETS61468.1 - 0.12 12.8 0.5 0.22 11.9 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3304) EF-hand_6 PF13405.6 ETS61468.1 - 0.19 11.7 0.0 0.46 10.6 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Nuc_sug_transp PF04142.15 ETS61469.1 - 5.3e-51 173.7 8.1 1.2e-45 156.1 5.9 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 ETS61469.1 - 0.026 14.7 0.4 0.026 14.7 0.4 2.8 3 0 0 3 3 3 0 EamA-like transporter family Acyl_transf_3 PF01757.22 ETS61470.1 - 2.1e-12 46.8 32.8 3e-12 46.3 32.8 1.2 1 0 0 1 1 1 1 Acyltransferase family DUF1772 PF08592.11 ETS61470.1 - 1.1 9.6 8.0 7.8 6.8 0.0 3.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Glyco_transf_90 PF05686.12 ETS61471.1 - 1.8e-18 66.7 0.7 1.8e-15 56.8 0.2 3.2 3 0 0 3 3 3 3 Glycosyl transferase family 90 RcnB PF11776.8 ETS61471.1 - 0.025 14.6 0.7 0.078 13.1 0.7 1.8 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator RNA_pol_L_2 PF13656.6 ETS61471.1 - 0.19 11.5 0.0 0.47 10.3 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Ribosomal_L22 PF00237.19 ETS61473.1 - 1.9e-23 82.7 0.2 4.2e-23 81.5 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e IMUP PF15761.5 ETS61474.1 - 0.045 14.4 4.2 0.078 13.7 4.2 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein SVIP PF15811.5 ETS61474.1 - 0.35 11.3 8.6 0.32 11.5 6.9 1.8 2 0 0 2 2 2 0 Small VCP/p97-interacting protein zf-CHCC PF10276.9 ETS61475.1 - 4.1e-18 65.2 2.0 6e-18 64.6 2.0 1.3 1 0 0 1 1 1 1 Zinc-finger domain Aminotran_5 PF00266.19 ETS61476.1 - 8.1e-87 291.6 0.0 1.8e-86 290.4 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V ThrE PF06738.12 ETS61477.1 - 5.5e-60 202.7 4.5 5.5e-60 202.7 4.5 2.4 2 1 0 2 2 2 1 Putative threonine/serine exporter ThrE_2 PF12821.7 ETS61477.1 - 2.8e-07 30.7 3.2 2.8e-07 30.7 3.2 2.3 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE UPF0016 PF01169.19 ETS61477.1 - 0.045 14.1 0.3 0.045 14.1 0.3 3.2 4 0 0 4 4 4 0 Uncharacterized protein family UPF0016 Peptidase_M43 PF05572.13 ETS61478.1 - 2.3e-16 60.1 0.0 3.5e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 ETS61478.1 - 3.5e-08 33.8 1.4 4.9e-08 33.3 1.1 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 ETS61478.1 - 9.1e-07 29.4 0.1 1.6e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ETS61478.1 - 0.0066 16.1 0.3 0.018 14.7 0.3 1.9 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 ETS61478.1 - 0.013 14.5 0.3 0.026 13.5 0.3 1.4 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M10 PF00413.24 ETS61478.1 - 0.031 14.1 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 Matrixin Reprolysin_2 PF13574.6 ETS61478.1 - 0.061 13.2 0.5 0.11 12.3 0.4 1.5 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Epimerase PF01370.21 ETS61479.1 - 1.7e-25 89.9 0.1 8.7e-25 87.6 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS61479.1 - 7.2e-23 81.5 0.2 6.6e-21 75.0 0.2 2.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ETS61479.1 - 5.1e-14 51.9 0.0 7.2e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETS61479.1 - 2.4e-10 40.0 0.0 3.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 ETS61479.1 - 4.5e-09 36.0 0.0 7e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ETS61479.1 - 2.1e-08 33.7 0.0 9.3e-07 28.3 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 ETS61479.1 - 1.1e-07 31.9 0.1 2.1e-07 31.0 0.1 1.4 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETS61479.1 - 1.3e-07 31.7 0.0 2.1e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding adh_short_C2 PF13561.6 ETS61479.1 - 2e-05 24.3 0.0 3e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.12 ETS61479.1 - 7.3e-05 22.1 0.1 0.0012 18.0 0.0 2.3 2 1 0 2 2 2 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 ETS61479.1 - 0.098 12.9 0.0 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 ETS61479.1 - 0.2 11.2 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Peptidase_S15 PF02129.18 ETS61480.1 - 4.8e-41 141.1 0.1 1.1e-38 133.4 0.0 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 ETS61480.1 - 1.4e-33 116.7 0.0 3.1e-33 115.6 0.0 1.5 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 ETS61480.1 - 0.0039 16.5 0.0 0.0072 15.6 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETS61480.1 - 0.046 13.2 0.0 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family AXE1 PF05448.12 ETS61480.1 - 0.23 10.1 0.1 14 4.3 0.0 2.2 1 1 1 2 2 2 0 Acetyl xylan esterase (AXE1) DUF1479 PF07350.12 ETS61481.1 - 1.7e-07 30.4 0.1 0.0048 15.7 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF1479) PhyH PF05721.13 ETS61481.1 - 2.5e-07 31.2 0.0 1.2e-06 29.0 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) MFS_1 PF07690.16 ETS61482.1 - 1.3e-48 165.8 46.2 1.2e-47 162.6 47.2 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETS61482.1 - 8.7e-21 74.0 18.4 1.3e-20 73.3 18.1 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ETS61482.1 - 2.6e-12 46.3 10.1 2.6e-12 46.3 10.1 3.3 4 0 0 4 4 4 2 Sugar (and other) transporter MFS_2 PF13347.6 ETS61482.1 - 0.00015 20.4 7.5 0.00015 20.4 7.5 3.5 1 1 1 3 3 3 1 MFS/sugar transport protein CrgA PF06781.12 ETS61482.1 - 0.067 13.3 5.8 0.074 13.1 0.1 3.5 3 1 0 3 3 3 0 Cell division protein CrgA Spore_YhaL PF14147.6 ETS61482.1 - 0.17 11.6 0.1 0.55 10.0 0.1 1.9 1 0 0 1 1 1 0 Sporulation protein YhaL MFS_1 PF07690.16 ETS61483.1 - 1.9e-19 69.8 23.8 1.9e-19 69.8 23.8 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61483.1 - 1.7e-12 47.0 5.5 1.7e-12 47.0 5.5 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter Glyco_hydro_127 PF07944.12 ETS61484.1 - 2.3e-104 349.8 0.0 2.8e-104 349.5 0.0 1.0 1 0 0 1 1 1 1 Beta-L-arabinofuranosidase, GH127 Sugar_tr PF00083.24 ETS61485.1 - 1.7e-67 228.3 23.9 2.2e-67 227.9 23.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS61485.1 - 1.1e-27 97.0 56.8 9.3e-22 77.4 24.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GP67 PF17634.2 ETS61487.1 - 0.089 13.2 6.3 0.14 12.6 6.3 1.2 1 0 0 1 1 1 0 Gene product 67 DNA_pol_phi PF04931.13 ETS61487.1 - 0.46 8.5 0.9 0.51 8.4 0.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi Sugar_tr PF00083.24 ETS61488.1 - 5e-78 263.0 21.5 5.8e-78 262.8 21.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS61488.1 - 8.6e-23 80.8 26.3 3.5e-21 75.5 23.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ETS61488.1 - 1.3e-06 28.0 1.5 1.3e-06 28.0 1.5 2.2 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Glyco_hydro_39 PF01229.17 ETS61489.1 - 0.00054 18.7 0.1 0.00074 18.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Glyco_hydro_31 PF01055.26 ETS61490.1 - 5.3e-105 352.1 0.2 1.1e-104 351.0 0.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ETS61490.1 - 4.5e-05 23.7 1.4 0.00025 21.3 0.2 2.8 3 1 0 3 3 3 1 Galactose mutarotase-like DUF4968 PF16338.5 ETS61490.1 - 0.0039 17.5 0.0 0.0064 16.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) Sugar_tr PF00083.24 ETS61491.1 - 8.9e-91 305.0 21.9 1.1e-90 304.7 21.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS61491.1 - 2.3e-31 109.0 45.9 5.1e-25 88.1 24.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ETS61491.1 - 0.013 13.9 3.3 0.019 13.3 1.8 1.9 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family AnmK PF03702.14 ETS61492.1 - 3.8e-88 296.1 0.0 4.4e-88 295.8 0.0 1.0 1 0 0 1 1 1 1 Anhydro-N-acetylmuramic acid kinase Methyltransf_2 PF00891.18 ETS61492.1 - 0.02 14.2 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Carbam_trans_N PF02543.15 ETS61492.1 - 0.1 12.2 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus KORA PF16509.5 ETS61492.1 - 0.16 12.3 0.2 3.4 8.0 0.0 2.3 2 0 0 2 2 2 0 TrfB plasmid transcriptional repressor PilM_2 PF11104.8 ETS61492.1 - 0.18 10.8 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; TENA_THI-4 PF03070.16 ETS61492.1 - 0.21 11.4 0.0 0.43 10.4 0.0 1.4 1 0 0 1 1 1 0 TENA/THI-4/PQQC family 3Beta_HSD PF01073.19 ETS61494.1 - 1.1e-15 57.4 0.0 2e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETS61494.1 - 2.2e-14 53.5 0.0 5.4e-14 52.2 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETS61494.1 - 1.2e-12 47.6 0.0 1.6e-11 43.9 0.0 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 ETS61494.1 - 9.5e-11 41.9 0.0 1.9e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ETS61494.1 - 1.8e-08 34.2 0.0 3.6e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ETS61494.1 - 1.9e-06 27.7 0.1 2.7e-06 27.1 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ETS61494.1 - 0.00032 20.2 0.0 0.0019 17.7 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ETS61494.1 - 0.00065 18.9 0.0 0.0011 18.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ETS61494.1 - 0.0098 15.8 0.1 0.05 13.5 0.1 2.0 1 1 0 1 1 1 1 KR domain Ldh_1_N PF00056.23 ETS61494.1 - 0.084 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Ribonuc_red_sm PF00268.21 ETS61495.1 - 4.4e-121 403.6 0.7 5.9e-121 403.2 0.7 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Hydrolase_4 PF12146.8 ETS61496.1 - 4.7e-08 32.6 0.1 1.6e-07 30.8 0.1 1.8 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS61496.1 - 1.1e-05 25.3 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS61496.1 - 4.7e-05 24.1 0.1 4.7e-05 24.1 0.1 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 ETS61496.1 - 0.00056 19.8 0.0 0.001 19.0 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) TPR_1 PF00515.28 ETS61496.1 - 0.075 12.9 0.6 10 6.1 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat PGAP1 PF07819.13 ETS61496.1 - 0.085 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Aldolase_II PF00596.21 ETS61497.1 - 8.9e-25 87.7 0.0 1.2e-24 87.3 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain DUF3533 PF12051.8 ETS61498.1 - 8.3e-100 334.3 15.9 9.8e-100 334.1 15.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) CrgA PF06781.12 ETS61498.1 - 1.7 8.8 5.7 32 4.7 1.3 3.5 3 1 0 3 3 3 0 Cell division protein CrgA Aa_trans PF01490.18 ETS61499.1 - 0.00017 20.4 8.6 0.0048 15.7 7.9 2.2 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein zf-RING_2 PF13639.6 ETS61500.1 - 1.5e-07 31.6 15.2 1.7e-06 28.2 2.4 3.6 3 1 0 3 3 3 2 Ring finger domain zf-rbx1 PF12678.7 ETS61500.1 - 6.4e-05 23.2 11.8 0.00068 19.9 2.3 3.2 3 0 0 3 3 3 2 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETS61500.1 - 0.0023 18.0 5.5 0.0033 17.4 0.4 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ETS61500.1 - 0.0027 17.5 10.8 0.064 13.1 0.5 3.0 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS61500.1 - 0.0067 16.4 8.0 0.031 14.3 1.0 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETS61500.1 - 0.0077 16.2 8.6 0.039 13.9 0.3 3.2 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ETS61500.1 - 0.015 15.1 0.8 0.015 15.1 0.8 3.3 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETS61500.1 - 0.035 13.8 3.0 6.9 6.5 0.1 3.3 3 0 0 3 3 3 0 RING-like zinc finger Prok-RING_4 PF14447.6 ETS61500.1 - 0.092 12.6 11.9 0.22 11.4 0.4 3.6 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETS61500.1 - 0.8 9.6 18.6 0.23 11.3 1.8 3.9 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 ETS61500.1 - 2.9 8.1 8.6 0.29 11.3 2.4 2.5 2 0 0 2 2 2 0 RING-variant domain Zn_ribbon_17 PF17120.5 ETS61500.1 - 3.5 7.3 11.1 1.7 8.3 1.4 2.9 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type GILT PF03227.16 ETS61502.1 - 5.3e-14 52.4 0.3 9.9e-14 51.5 0.3 1.4 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) 4HBT PF03061.22 ETS61503.1 - 3.9e-06 27.1 0.0 0.045 14.1 0.0 2.6 2 0 0 2 2 2 2 Thioesterase superfamily Pkinase PF00069.25 ETS61504.1 - 2.7e-54 184.3 0.0 5.9e-54 183.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain DUF3543 PF12063.8 ETS61504.1 - 1.3e-50 172.2 0.0 2.6e-50 171.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_Tyr PF07714.17 ETS61504.1 - 1.6e-40 139.0 0.0 4.2e-40 137.7 0.0 1.6 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS61504.1 - 0.04 12.7 0.0 0.074 11.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase WD40 PF00400.32 ETS61505.1 - 2.3e-26 91.5 21.4 1.9e-06 28.5 0.3 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS61505.1 - 5e-11 42.8 0.1 6.9e-05 23.1 0.0 4.3 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETS61505.1 - 0.00022 20.7 0.0 0.00073 18.9 0.0 1.9 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 ETS61505.1 - 0.00085 18.4 0.9 2.6 6.9 0.0 4.0 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 ETS61505.1 - 0.0023 16.3 0.0 0.0057 15.0 0.0 1.6 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz IKI3 PF04762.12 ETS61505.1 - 0.0087 14.1 0.1 0.016 13.2 0.0 1.4 1 1 0 1 1 1 1 IKI3 family PQQ_3 PF13570.6 ETS61505.1 - 0.055 14.0 13.2 1.2 9.7 0.0 5.0 5 0 0 5 5 5 0 PQQ-like domain MutS_V PF00488.21 ETS61506.1 - 2.9e-49 167.7 0.0 4.9e-49 166.9 0.0 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETS61506.1 - 3.1e-28 99.3 5.2 3.1e-28 99.3 5.2 2.0 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ETS61506.1 - 0.00012 22.4 0.0 0.00034 20.9 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 ETS61506.1 - 0.0002 21.7 0.2 0.00036 20.8 0.2 1.5 1 0 0 1 1 1 1 MutS family domain IV AAA_29 PF13555.6 ETS61506.1 - 0.009 15.7 0.0 0.027 14.2 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ETS61506.1 - 0.013 16.0 0.1 0.044 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 ETS61506.1 - 0.027 13.6 0.1 3.1 6.9 0.0 2.4 2 1 0 2 2 2 0 G-protein alpha subunit AAA_25 PF13481.6 ETS61506.1 - 0.14 11.7 0.0 1 8.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain Ribosomal_L7Ae PF01248.26 ETS61507.1 - 3.3e-27 94.1 0.1 4.1e-27 93.7 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 ETS61507.1 - 0.002 17.9 0.0 0.0028 17.5 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 ETS61507.1 - 0.0059 16.7 0.0 0.0072 16.4 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 UPF0203 PF05254.12 ETS61510.1 - 2.6e-21 75.6 2.7 1.7e-20 73.0 2.7 2.0 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0203) P33MONOX PF15302.6 ETS61510.1 - 0.00066 19.5 0.9 0.00077 19.3 0.9 1.2 1 0 0 1 1 1 1 P33 mono-oxygenase UCR_hinge PF02320.16 ETS61510.1 - 0.0011 19.1 0.4 0.98 9.7 0.0 2.3 2 0 0 2 2 2 2 Ubiquinol-cytochrome C reductase hinge protein NDUF_B7 PF05676.13 ETS61510.1 - 0.025 14.3 1.2 4.2 7.2 0.1 2.3 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF5339 PF17274.2 ETS61510.1 - 0.11 13.4 1.3 0.4 11.6 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5339) PRK PF00485.18 ETS61511.1 - 8.9e-07 28.8 0.1 3.6e-06 26.9 0.1 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ETS61511.1 - 0.0024 18.4 0.0 0.13 12.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETS61511.1 - 0.01 16.3 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 ETS61511.1 - 0.05 12.7 0.2 0.078 12.0 0.2 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 ETS61511.1 - 0.2 11.8 0.4 1.2 9.3 0.2 2.1 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 ETS61512.1 - 5.6e-67 224.6 0.0 6.2e-67 224.4 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETS61512.1 - 9.6e-11 41.4 0.1 3.9e-07 29.6 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ETS61512.1 - 1.8e-09 37.3 0.0 2.4e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ETS61512.1 - 1.5e-08 34.4 0.0 1.7e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61512.1 - 2.2e-08 34.3 0.0 5.4e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETS61512.1 - 9.5e-08 32.1 0.0 1.8e-07 31.2 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETS61512.1 - 1.3e-05 24.7 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ETS61512.1 - 0.036 13.8 0.0 0.13 12.0 0.0 1.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation CENP-M PF11111.8 ETS61512.1 - 0.052 12.7 0.0 0.23 10.7 0.0 1.8 2 0 0 2 2 2 0 Centromere protein M (CENP-M) IF4E PF01652.18 ETS61513.1 - 4.1e-50 169.7 0.0 5.3e-50 169.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TAF8_C PF10406.9 ETS61514.1 - 8.2e-07 29.5 5.9 0.00063 20.3 1.2 2.8 2 0 0 2 2 2 2 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 ETS61514.1 - 8.5e-06 25.7 0.1 1.4e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated CCDC106 PF15794.5 ETS61514.1 - 1.7 8.3 5.6 3.2 7.4 5.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Rhodanese PF00581.20 ETS61515.1 - 1.3e-09 38.5 0.0 2.6e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain HalOD1 PF18545.1 ETS61515.1 - 0.058 13.7 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 Halobacterial output domain 1 ECH_1 PF00378.20 ETS61516.1 - 2.1e-31 109.1 0.5 4e-31 108.2 0.5 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS61516.1 - 1.7e-13 50.8 1.2 2.9e-13 50.0 1.1 1.5 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Adenyl_cycl_N PF12633.7 ETS61517.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Adenylate cyclase NT domain Amidohydro_1 PF01979.20 ETS61518.1 - 0.0006 19.2 0.0 0.00082 18.8 0.0 1.2 1 0 0 1 1 1 1 Amidohydrolase family adh_short_C2 PF13561.6 ETS61519.1 - 2.6e-37 128.6 0.0 3.3e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS61519.1 - 3.4e-26 91.9 0.0 5.5e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS61519.1 - 0.0017 18.3 0.0 0.0027 17.6 0.0 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 ETS61519.1 - 0.0067 15.8 0.1 0.013 14.9 0.1 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain IlvN PF07991.12 ETS61519.1 - 0.031 13.9 0.1 0.063 12.8 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain Eno-Rase_NADH_b PF12242.8 ETS61519.1 - 0.051 13.3 3.3 0.085 12.6 2.6 1.7 1 1 1 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_7 PF13241.6 ETS61519.1 - 0.15 12.6 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase PF00069.25 ETS61520.1 - 1.5e-58 198.2 0.0 1.6e-33 116.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61520.1 - 1.4e-20 73.7 0.0 1.6e-18 66.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Elong_Iki1 PF10483.9 ETS61520.1 - 1.2e-15 57.8 0.1 5.8e-09 35.9 0.0 2.3 2 0 0 2 2 2 2 Elongator subunit Iki1 Kdo PF06293.14 ETS61520.1 - 0.0004 19.8 0.1 0.0008 18.8 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETS61520.1 - 0.025 13.6 0.0 0.041 12.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain bZIP_1 PF00170.21 ETS61521.1 - 3.5e-10 39.8 8.0 7.6e-10 38.8 7.9 1.6 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ETS61521.1 - 1.3e-08 34.7 6.4 1.9e-08 34.3 5.7 1.6 1 1 0 1 1 1 1 Basic region leucine zipper RAC_head PF16717.5 ETS61521.1 - 0.00084 20.3 2.7 0.0015 19.4 2.7 1.4 1 0 0 1 1 1 1 Ribosome-associated complex head domain Herpes_BLRF2 PF05812.12 ETS61521.1 - 0.0016 18.6 0.3 0.15 12.2 0.1 2.5 2 0 0 2 2 2 1 Herpesvirus BLRF2 protein Spc7 PF08317.11 ETS61521.1 - 0.019 13.9 2.0 0.03 13.2 2.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ETS61521.1 - 0.033 14.6 0.4 0.086 13.3 0.4 1.7 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) YabA PF06156.13 ETS61521.1 - 0.036 14.7 1.0 0.069 13.8 0.7 1.6 1 1 0 1 1 1 0 Initiation control protein YabA Yuri_gagarin PF15934.5 ETS61521.1 - 0.048 13.5 1.7 0.076 12.8 1.7 1.2 1 0 0 1 1 1 0 Yuri gagarin Phlebovirus_NSM PF07246.11 ETS61521.1 - 0.052 12.9 2.3 0.073 12.4 2.3 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M PKcGMP_CC PF16808.5 ETS61521.1 - 0.074 12.9 0.7 0.2 11.6 0.7 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC_tran_CTD PF16326.5 ETS61521.1 - 0.28 11.5 1.1 0.66 10.3 1.1 1.7 1 0 0 1 1 1 0 ABC transporter C-terminal domain Macoilin PF09726.9 ETS61521.1 - 0.52 8.8 6.3 0.69 8.4 6.3 1.1 1 0 0 1 1 1 0 Macoilin family Ribosomal_S20p PF01649.18 ETS61521.1 - 1.3 9.7 6.9 1 10.0 2.7 2.2 1 1 1 2 2 2 0 Ribosomal protein S20 CASP_C PF08172.12 ETS61521.1 - 2.1 7.6 7.9 5.8 6.2 7.9 1.9 1 1 0 1 1 1 0 CASP C terminal DivIC PF04977.15 ETS61521.1 - 3.8 7.4 7.8 0.3 10.9 2.7 1.8 2 0 0 2 2 2 0 Septum formation initiator FAM76 PF16046.5 ETS61521.1 - 4.7 6.5 6.6 7 5.9 6.6 1.2 1 0 0 1 1 1 0 FAM76 protein bZIP_Maf PF03131.17 ETS61521.1 - 7.1 7.2 10.4 0.41 11.2 5.2 1.6 2 0 0 2 2 1 0 bZIP Maf transcription factor TFIID-31kDa PF02291.15 ETS61522.1 - 2.3e-46 156.8 0.0 3.5e-46 156.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ETS61522.1 - 0.0066 16.4 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated ANAPC_CDC26 PF10471.9 ETS61522.1 - 0.25 12.2 9.8 0.15 12.9 8.0 1.5 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Ribosomal_S14 PF00253.21 ETS61523.1 - 6e-24 83.6 1.1 1.2e-23 82.6 0.2 1.9 2 1 1 3 3 3 1 Ribosomal protein S14p/S29e QLQ PF08880.11 ETS61523.1 - 0.025 14.3 0.1 0.072 12.9 0.0 1.8 1 1 0 1 1 1 0 QLQ SIP1 PF04938.12 ETS61524.1 - 3.9e-28 98.7 0.0 9e-28 97.5 0.0 1.5 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) MFS_1 PF07690.16 ETS61526.1 - 1.6e-29 103.0 34.6 1.1e-26 93.7 15.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61526.1 - 1.1e-15 57.4 2.1 1.1e-15 57.4 2.1 2.5 3 0 0 3 3 3 2 Sugar (and other) transporter MFS_4 PF06779.14 ETS61526.1 - 0.0013 18.1 2.5 0.0013 18.1 2.5 2.6 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB MFS_Mycoplasma PF07672.13 ETS61526.1 - 0.64 9.3 4.3 3.9 6.7 0.0 2.8 3 0 0 3 3 3 0 Mycoplasma MFS transporter DUF2157 PF09925.9 ETS61526.1 - 2.8 7.7 12.9 8.9 6.1 1.1 3.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) COX15-CtaA PF02628.15 ETS61527.1 - 2.8e-91 306.0 13.8 8.2e-91 304.4 13.8 1.8 1 1 0 1 1 1 1 Cytochrome oxidase assembly protein Ribosomal_L19 PF01245.20 ETS61528.1 - 6.2e-16 58.3 0.1 1e-15 57.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 Not3 PF04065.15 ETS61529.1 - 8.1e-89 297.0 25.0 1.6e-88 296.1 25.0 1.5 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 ETS61529.1 - 9e-46 155.2 10.4 2.5e-45 153.8 10.4 1.8 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF2373 PF10180.9 ETS61529.1 - 0.006 16.4 3.7 0.016 15.1 3.7 1.7 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) IL11 PF07400.11 ETS61529.1 - 0.037 13.7 1.6 0.1 12.3 1.6 1.8 1 0 0 1 1 1 0 Interleukin 11 Ribonuclease_3 PF00636.26 ETS61531.1 - 1.7e-33 115.3 0.0 3.3e-19 69.4 0.0 2.7 2 0 0 2 2 2 2 Ribonuclease III domain Dicer_dimer PF03368.14 ETS61531.1 - 5.4e-20 71.3 0.1 1.4e-19 70.0 0.1 1.7 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 ETS61531.1 - 2.5e-18 66.5 0.2 2.4e-09 37.5 0.0 3.6 2 2 0 2 2 2 2 Ribonuclease-III-like Helicase_C PF00271.31 ETS61531.1 - 6.9e-13 48.9 0.0 1.7e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS61531.1 - 1.5e-08 34.6 0.0 3.5e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETS61531.1 - 3.9e-08 33.5 0.0 6.6e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit dsrm PF00035.26 ETS61531.1 - 0.0044 17.7 0.0 0.0099 16.6 0.0 1.6 1 0 0 1 1 1 1 Double-stranded RNA binding motif cwf21 PF08312.12 ETS61532.1 - 2e-15 56.6 8.9 2e-15 56.6 8.9 3.5 2 2 1 3 3 3 1 cwf21 domain WLM PF08325.10 ETS61533.1 - 5.2e-28 98.4 1.5 1.6e-27 96.9 0.7 2.1 2 1 0 2 2 2 1 WLM domain ubiquitin PF00240.23 ETS61533.1 - 0.0022 17.7 0.1 0.016 14.9 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin family DUF45 PF01863.17 ETS61533.1 - 0.02 14.9 0.1 0.049 13.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF45 Acyl-CoA_dh_1 PF00441.24 ETS61534.1 - 3.4e-27 95.5 4.4 5.2e-27 94.9 4.4 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS61534.1 - 7.9e-19 67.7 0.0 1.7e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETS61534.1 - 7.3e-11 42.5 4.4 1.3e-10 41.6 4.4 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETS61534.1 - 1.9e-10 41.4 0.0 3.8e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain MCM PF00493.23 ETS61535.1 - 2.7e-103 343.9 0.0 4e-103 343.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain SLAC1 PF03595.17 ETS61535.1 - 2.3e-70 237.4 41.7 3e-70 237.0 41.7 1.1 1 0 0 1 1 1 1 Voltage-dependent anion channel MCM_OB PF17207.3 ETS61535.1 - 2.9e-30 104.7 0.1 5.1e-30 103.9 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETS61535.1 - 6.5e-20 71.3 0.0 2e-19 69.8 0.0 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ETS61535.1 - 4.2e-14 53.0 0.0 1.3e-13 51.4 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 ETS61535.1 - 1.1e-07 31.9 0.0 4.7e-06 26.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETS61535.1 - 8.3e-07 28.6 0.0 3.3e-05 23.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETS61535.1 - 0.028 14.3 0.0 0.095 12.6 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ras PF00071.22 ETS61536.1 - 8.6e-43 145.7 0.2 1.2e-40 138.8 0.1 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETS61536.1 - 7.7e-32 110.0 0.1 1.3e-31 109.3 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61536.1 - 4.6e-11 42.5 0.1 7.4e-11 41.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS61536.1 - 1.2e-05 25.3 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ETS61536.1 - 0.0029 17.1 0.0 0.0047 16.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETS61536.1 - 0.07 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region AhpC-TSA PF00578.21 ETS61537.1 - 2.3e-30 105.1 0.0 3e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ETS61537.1 - 1.3e-10 41.2 0.0 1.6e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ETS61537.1 - 6.1e-10 38.8 0.0 1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin AhpC-TSA_2 PF13911.6 ETS61537.1 - 0.092 12.9 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 AhpC/TSA antioxidant enzyme AMMECR1 PF01871.17 ETS61538.1 - 1.6e-42 145.0 0.0 6.4e-42 143.0 0.0 1.8 1 1 0 1 1 1 1 AMMECR1 TspO_MBR PF03073.15 ETS61539.1 - 4.9e-46 156.1 9.0 5.6e-46 155.9 9.0 1.0 1 0 0 1 1 1 1 TspO/MBR family SBDS PF01172.18 ETS61541.1 - 2.6e-16 59.5 0.0 3.3e-16 59.1 0.0 1.2 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Swi6_N PF18530.1 ETS61541.1 - 0.01 16.0 0.0 0.02 15.0 0.0 1.5 1 0 0 1 1 1 0 Swi6 N-terminal domain SNF5 PF04855.12 ETS61542.1 - 8.8e-66 222.1 2.2 9.7e-60 202.3 0.9 2.1 2 0 0 2 2 2 2 SNF5 / SMARCB1 / INI1 tRNA-synt_2 PF00152.20 ETS61543.1 - 2.7e-85 286.2 0.0 1.3e-45 155.9 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ETS61543.1 - 8.8e-06 25.6 0.0 1.7e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ETS61543.1 - 0.2 11.1 0.1 1.6 8.1 0.0 2.4 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) LIM PF00412.22 ETS61544.1 - 7.3e-28 96.6 33.7 1.9e-12 47.2 2.9 5.0 4 1 0 4 4 4 4 LIM domain ketoacyl-synt PF00109.26 ETS61546.1 - 3.1e-58 197.3 0.2 5.6e-58 196.5 0.2 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ETS61546.1 - 2.7e-22 79.7 0.9 5.7e-22 78.6 0.9 1.6 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis PP-binding PF00550.25 ETS61546.1 - 1.9e-21 76.2 5.0 1.7e-10 41.1 1.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site Thioesterase PF00975.20 ETS61546.1 - 9.3e-18 65.2 1.3 2.7e-16 60.4 0.1 3.0 3 0 0 3 3 3 1 Thioesterase domain Ketoacyl-synt_C PF02801.22 ETS61546.1 - 2.1e-13 50.3 0.7 6.3e-13 48.8 0.7 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 ETS61546.1 - 0.00019 21.9 0.0 0.0011 19.4 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension Zn_clus PF00172.18 ETS61547.1 - 0.031 14.4 11.3 0.38 10.9 11.3 2.2 1 1 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Ndc1_Nup PF09531.10 ETS61549.1 - 5.2e-72 243.4 8.4 6.6e-72 243.1 8.4 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Sod_Fe_C PF02777.18 ETS61550.1 - 3.5e-21 75.3 0.1 1.1e-09 38.4 0.1 2.3 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain ketoacyl-synt PF00109.26 ETS61551.1 - 3.6e-47 161.1 0.3 1.2e-46 159.3 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 ETS61551.1 - 1.9e-35 122.9 0.0 3.8e-35 121.9 0.0 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 ETS61551.1 - 2e-29 102.0 2.1 3.8e-29 101.1 0.1 2.5 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Thioesterase PF00975.20 ETS61551.1 - 5e-19 69.3 0.4 5.6e-18 65.9 0.1 2.8 2 1 0 2 2 2 1 Thioesterase domain PS-DH PF14765.6 ETS61551.1 - 5.8e-18 65.1 0.0 1e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase SAT PF16073.5 ETS61551.1 - 0.0039 16.9 1.2 0.076 12.7 0.0 3.0 2 1 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis SNARE_assoc PF09335.11 ETS61553.1 - 4.1e-14 53.1 4.4 4.1e-14 53.1 4.4 2.0 2 0 0 2 2 2 1 SNARE associated Golgi protein FSH1 PF03959.13 ETS61553.1 - 4.1e-12 46.2 0.0 7.4e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) UPF0160 PF03690.13 ETS61554.1 - 3.2e-131 437.7 0.0 4e-131 437.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) cobW PF02492.19 ETS61554.1 - 2.1e-33 115.4 0.0 3.8e-33 114.5 0.0 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ETS61554.1 - 0.0032 17.9 0.1 0.021 15.2 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain MeaB PF03308.16 ETS61554.1 - 0.0078 15.2 2.6 0.073 12.0 2.6 2.1 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 ETS61554.1 - 0.014 16.0 0.0 0.063 13.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF4841 PF16129.5 ETS61554.1 - 0.039 14.2 0.0 0.088 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4841) Pox_A32 PF04665.12 ETS61554.1 - 0.058 12.9 0.0 0.095 12.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_5 PF07728.14 ETS61554.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETS61554.1 - 0.12 12.9 0.0 0.26 11.8 0.0 1.5 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 ETS61554.1 - 0.12 12.3 0.1 0.47 10.3 0.0 2.0 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 ETS61554.1 - 0.17 11.7 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea APH PF01636.23 ETS61555.1 - 3.7e-37 128.5 0.0 5e-37 128.1 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ETS61555.1 - 0.00017 21.0 0.0 0.00025 20.4 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ETS61555.1 - 0.02 14.5 0.0 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase BTB PF00651.31 ETS61556.1 - 6.3e-07 29.6 0.0 5.5e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 BTB/POZ domain Acyltransferase PF01553.21 ETS61557.1 - 2e-33 114.9 0.0 3.1e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Kinesin PF00225.23 ETS61558.1 - 3.6e-53 180.7 0.0 8.2e-53 179.5 0.0 1.5 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETS61558.1 - 2.3e-06 27.6 0.0 4.3e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding AAA_16 PF13191.6 ETS61558.1 - 0.57 10.5 11.0 0.054 13.9 2.6 3.0 2 2 0 2 2 2 0 AAA ATPase domain His_Phos_2 PF00328.22 ETS61559.1 - 4.4e-30 105.3 0.0 1.1e-29 104.0 0.0 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MoCF_biosynth PF00994.24 ETS61560.1 - 6.2e-33 113.5 0.0 9.5e-33 112.9 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain CinA_KH PF18146.1 ETS61560.1 - 0.036 14.2 0.0 0.083 13.1 0.0 1.6 1 0 0 1 1 1 0 Damage-inducible protein CinA KH domain AAA_2 PF07724.14 ETS61561.1 - 1.4e-46 158.7 0.0 5.1e-45 153.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ETS61561.1 - 1.2e-32 112.0 1.1 1.2e-32 112.0 1.1 3.1 2 1 1 3 3 2 1 AAA lid domain AAA PF00004.29 ETS61561.1 - 7.1e-26 91.2 0.0 8.1e-16 58.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ETS61561.1 - 1.3e-18 66.8 0.2 5.1e-18 64.9 0.2 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 ETS61561.1 - 7e-14 52.0 0.0 2.3e-08 34.1 0.0 3.3 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 ETS61561.1 - 2.7e-13 49.8 9.8 1.1e-06 28.7 0.3 4.2 4 0 0 4 4 3 2 Clp amino terminal domain, pathogenicity island component AAA_16 PF13191.6 ETS61561.1 - 2.8e-10 40.8 10.5 1.2e-05 25.8 0.0 5.6 4 2 0 5 5 5 2 AAA ATPase domain Sigma54_activat PF00158.26 ETS61561.1 - 2e-09 37.4 0.0 1.7e-07 31.1 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 ETS61561.1 - 1.1e-06 29.0 0.2 0.045 14.0 0.0 4.4 2 2 0 2 2 2 1 AAA domain TniB PF05621.11 ETS61561.1 - 1.9e-06 27.4 0.0 0.004 16.6 0.0 3.4 3 0 0 3 3 3 1 Bacterial TniB protein Zeta_toxin PF06414.12 ETS61561.1 - 4e-06 26.2 0.0 0.0032 16.8 0.0 3.1 3 0 0 3 3 2 1 Zeta toxin Mg_chelatase PF01078.21 ETS61561.1 - 0.00011 21.7 0.2 0.61 9.4 0.1 3.5 3 1 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 ETS61561.1 - 0.00032 20.9 1.7 0.85 9.8 0.0 3.6 4 0 0 4 4 3 2 AAA domain AAA_7 PF12775.7 ETS61561.1 - 0.00047 19.7 0.0 1.3 8.5 0.0 3.0 3 0 0 3 3 3 2 P-loop containing dynein motor region TsaE PF02367.17 ETS61561.1 - 0.0012 18.8 0.0 2.5 8.1 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE IstB_IS21 PF01695.17 ETS61561.1 - 0.0016 18.2 0.0 0.1 12.3 0.0 2.7 2 0 0 2 2 2 1 IstB-like ATP binding protein NACHT PF05729.12 ETS61561.1 - 0.0025 17.8 0.0 2.8 7.8 0.0 2.8 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 ETS61561.1 - 0.0026 17.5 0.0 5.5 6.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 ETS61561.1 - 0.0028 18.0 0.1 6.1 7.3 0.0 3.2 3 0 0 3 3 3 0 RNA helicase RuvB_N PF05496.12 ETS61561.1 - 0.0029 17.4 0.0 5.5 6.7 0.0 3.4 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Torsin PF06309.11 ETS61561.1 - 0.0037 17.4 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 Torsin AAA_19 PF13245.6 ETS61561.1 - 0.0038 17.6 0.0 0.13 12.6 0.0 3.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETS61561.1 - 0.006 16.5 0.0 1.4 8.8 0.0 2.8 2 0 0 2 2 2 1 RsgA GTPase AAA_28 PF13521.6 ETS61561.1 - 0.0079 16.5 4.8 0.47 10.7 0.0 3.9 3 1 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 ETS61561.1 - 0.0082 16.1 1.3 0.7 9.8 0.0 4.0 4 0 0 4 4 4 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 ETS61561.1 - 0.0091 16.5 1.3 4.7 7.8 0.0 3.3 3 0 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.9 ETS61561.1 - 0.0094 14.9 0.0 4.7 6.0 0.0 3.2 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Roc PF08477.13 ETS61561.1 - 0.012 15.8 0.0 2.7 8.3 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ETS61561.1 - 0.013 15.2 0.1 8.6 6.2 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain DUF815 PF05673.13 ETS61561.1 - 0.019 14.1 0.0 0.7 9.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) cobW PF02492.19 ETS61561.1 - 0.046 13.3 0.1 6.8 6.2 0.0 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Oxidored_molyb PF00174.19 ETS61561.1 - 0.047 13.3 0.0 0.097 12.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase molybdopterin binding domain ABC_tran PF00005.27 ETS61561.1 - 0.051 14.1 0.4 16 6.0 0.0 3.3 3 0 0 3 3 3 0 ABC transporter AAA_3 PF07726.11 ETS61561.1 - 0.064 13.1 0.0 10 6.0 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 ETS61561.1 - 0.077 13.0 0.0 3.7 7.6 0.0 3.0 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Spc7 PF08317.11 ETS61561.1 - 0.14 11.0 8.8 0.26 10.1 8.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF16 PF01519.16 ETS61561.1 - 0.29 11.7 4.3 6.4 7.3 0.2 3.4 2 1 1 3 3 2 0 Protein of unknown function DUF16 AAA_25 PF13481.6 ETS61561.1 - 0.33 10.5 3.5 2.7 7.5 0.0 2.9 3 0 0 3 3 2 0 AAA domain EMP24_GP25L PF01105.24 ETS61561.1 - 0.45 10.4 2.3 0.54 10.2 0.8 1.9 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF724 PF05266.14 ETS61561.1 - 1.5 8.6 4.8 3.8 7.3 4.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CDH-cyt PF16010.5 ETS61562.1 - 3.4e-10 39.9 9.2 1.9e-06 27.7 4.1 2.4 1 1 1 2 2 2 2 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 ETS61562.1 - 1.1e-08 35.3 8.9 2.4e-08 34.2 8.9 1.6 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 ETS61562.1 - 5e-06 26.7 8.1 1.1e-05 25.6 6.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF4079) DOMON PF03351.17 ETS61562.1 - 6.4e-06 26.4 1.5 1.4e-05 25.3 1.5 1.6 1 0 0 1 1 1 1 DOMON domain DUF2427 PF10348.9 ETS61562.1 - 9.7e-06 25.3 2.9 9.7e-06 25.3 2.9 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DUF420 PF04238.12 ETS61562.1 - 0.092 13.0 3.9 0.33 11.2 3.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF420) TctB PF07331.11 ETS61562.1 - 3.7 7.8 14.2 3.2 8.0 3.0 2.4 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family E1-E2_ATPase PF00122.20 ETS61563.1 - 2.9e-43 147.5 1.0 2.9e-43 147.5 1.0 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETS61563.1 - 1.9e-40 138.5 2.6 1.9e-40 138.5 2.6 3.1 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETS61563.1 - 6.4e-20 72.3 0.0 2.5e-08 34.5 0.0 3.7 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS61563.1 - 2.1e-14 53.4 0.0 4.6e-14 52.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ETS61563.1 - 7.9e-12 44.7 0.5 1.6e-11 43.7 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ETS61563.1 - 0.00088 19.1 0.5 0.0016 18.2 0.5 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SUR7 PF06687.12 ETS61563.1 - 0.014 15.0 0.5 0.014 15.0 0.5 2.8 3 0 0 3 3 3 0 SUR7/PalI family DUF805 PF05656.14 ETS61563.1 - 0.022 15.2 4.0 0.13 12.7 0.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF805) COX15-CtaA PF02628.15 ETS61563.1 - 0.055 12.5 1.4 0.59 9.1 0.1 2.4 2 0 0 2 2 2 0 Cytochrome oxidase assembly protein DUF2207 PF09972.9 ETS61563.1 - 0.19 10.5 5.1 2.9 6.5 0.1 2.6 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF4181 PF13789.6 ETS61563.1 - 0.83 9.9 6.4 1.4 9.2 0.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) DUF2231 PF09990.9 ETS61563.1 - 8.3 6.9 7.5 0.85 10.1 0.5 2.9 3 0 0 3 3 2 0 Predicted membrane protein (DUF2231) Glyco_hydro_79C PF16862.5 ETS61564.1 - 1.3e-19 71.0 5.0 7.4e-19 68.6 1.5 2.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Herpes_gE PF02480.16 ETS61564.1 - 0.012 14.4 0.0 0.022 13.5 0.0 1.3 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Orthoreo_P10 PF07204.11 ETS61564.1 - 0.045 13.7 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Shisa PF13908.6 ETS61564.1 - 0.7 10.1 9.5 28 4.9 9.5 2.4 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator zf-Tim10_DDP PF02953.15 ETS61567.1 - 1.3e-19 69.6 3.8 1.3e-19 69.6 3.8 1.7 1 1 1 2 2 2 1 Tim10/DDP family zinc finger eIF-6 PF01912.18 ETS61568.1 - 7.8e-81 270.2 0.4 1.3e-80 269.5 0.2 1.4 1 1 1 2 2 2 1 eIF-6 family Tctex-1 PF03645.13 ETS61569.1 - 0.081 13.2 0.0 1.4 9.2 0.0 2.1 2 0 0 2 2 2 0 Tctex-1 family EnY2 PF10163.9 ETS61570.1 - 6.1e-20 71.4 0.0 7.2e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 DUF668 PF05003.12 ETS61570.1 - 0.13 12.7 0.3 9.6 6.8 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF668) RNA_Me_trans PF04252.13 ETS61571.1 - 7.7e-72 241.1 0.0 9.4e-72 240.8 0.0 1.1 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase GTP_cyclohydroI PF01227.22 ETS61572.1 - 3.4e-73 244.9 0.2 4.4e-73 244.5 0.2 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ETS61572.1 - 0.0038 17.4 0.0 0.011 15.9 0.0 1.7 2 0 0 2 2 2 1 QueF-like protein HATPase_c_2 PF13581.6 ETS61572.1 - 0.024 14.6 0.1 0.057 13.4 0.1 1.6 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Ribosomal_S25 PF03297.15 ETS61573.1 - 7.6e-38 128.8 1.8 1.1e-37 128.2 1.8 1.2 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 ETS61573.1 - 0.025 14.1 0.2 0.047 13.3 0.2 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Mt_ATP-synt_D PF05873.12 ETS61574.1 - 2.4e-16 59.9 2.5 2.9e-16 59.7 2.5 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) DltD PF04914.12 ETS61574.1 - 0.0055 16.2 4.0 0.0064 15.9 4.0 1.0 1 0 0 1 1 1 1 DltD protein GAS PF13851.6 ETS61574.1 - 0.019 14.3 9.2 0.031 13.6 9.2 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding AcetDehyd-dimer PF09290.11 ETS61574.1 - 0.025 14.8 0.3 0.8 9.9 0.1 2.2 1 1 1 2 2 2 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation Peptidase_M17_N PF02789.17 ETS61574.1 - 0.027 14.3 0.8 0.061 13.2 0.1 1.9 1 1 0 2 2 2 0 Cytosol aminopeptidase family, N-terminal domain Spc24 PF08286.11 ETS61574.1 - 0.038 14.2 1.5 2.6 8.3 0.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF948 PF06103.11 ETS61574.1 - 0.043 14.1 4.1 0.47 10.7 1.6 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) RPW8 PF05659.11 ETS61574.1 - 0.07 12.8 1.3 0.32 10.7 0.4 2.1 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 CT_C_D PF02682.16 ETS61574.1 - 0.08 12.7 0.9 0.11 12.2 0.9 1.2 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D DUF2570 PF10828.8 ETS61574.1 - 0.089 12.6 9.5 0.24 11.2 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) Vps51 PF08700.11 ETS61574.1 - 0.091 12.9 6.1 0.47 10.6 1.4 2.3 1 1 1 2 2 2 0 Vps51/Vps67 Dor1 PF04124.12 ETS61574.1 - 0.12 11.1 4.9 0.15 10.7 4.9 1.1 1 0 0 1 1 1 0 Dor1-like family DUF2408 PF10303.9 ETS61574.1 - 0.13 12.8 6.2 0.17 12.4 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Prominin PF05478.11 ETS61574.1 - 0.18 9.7 1.5 0.21 9.5 1.5 1.1 1 0 0 1 1 1 0 Prominin Spc7 PF08317.11 ETS61574.1 - 0.28 10.0 7.7 0.8 8.5 8.0 1.5 1 1 1 2 2 2 0 Spc7 kinetochore protein Prefoldin_2 PF01920.20 ETS61574.1 - 0.42 10.6 9.9 2.9 7.9 9.9 2.1 1 1 0 1 1 1 0 Prefoldin subunit TMPIT PF07851.13 ETS61574.1 - 0.44 9.7 5.0 0.64 9.2 4.6 1.4 1 1 1 2 2 2 0 TMPIT-like protein PRP1_N PF06424.12 ETS61574.1 - 1.5 9.2 5.7 6.2 7.2 5.7 1.9 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal MbeB_N PF04837.12 ETS61574.1 - 1.7 9.0 5.9 0.7 10.2 1.2 2.5 3 0 0 3 3 3 0 MbeB-like, N-term conserved region DUF4140 PF13600.6 ETS61574.1 - 1.9 9.0 6.5 6.5 7.3 1.1 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) THOC7 PF05615.13 ETS61574.1 - 1.9 8.7 10.0 2.1 8.6 2.1 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 DUF2203 PF09969.9 ETS61574.1 - 2.2 9.0 7.3 3.4 8.4 1.8 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FlxA PF14282.6 ETS61574.1 - 4.2 7.4 13.4 12 5.9 3.1 2.2 1 1 1 2 2 2 0 FlxA-like protein DivIC PF04977.15 ETS61574.1 - 4.3 7.2 11.4 1 9.1 1.1 2.4 1 1 0 2 2 2 0 Septum formation initiator APG6_N PF17675.1 ETS61574.1 - 8.5 6.9 10.8 85 3.7 10.8 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region cNMP_binding PF00027.29 ETS61575.1 - 9.1e-38 128.2 1.5 2.2e-18 66.1 0.1 3.0 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 ETS61575.1 - 8.4e-15 54.2 0.3 1.6e-14 53.3 0.3 1.5 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Cupin_2 PF07883.11 ETS61575.1 - 0.085 12.6 0.5 0.67 9.7 0.1 2.4 3 0 0 3 3 3 0 Cupin domain Abhydrolase_6 PF12697.7 ETS61576.1 - 6.9e-09 36.6 3.4 1.2e-08 35.9 3.4 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS61576.1 - 0.00015 21.1 0.0 0.00045 19.6 0.0 1.8 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 ETS61576.1 - 0.00024 20.8 0.0 0.00075 19.2 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Abhydrolase_1 PF00561.20 ETS61576.1 - 0.00059 19.5 0.1 1.9 8.0 0.0 3.1 2 1 0 2 2 2 2 alpha/beta hydrolase fold Aft1_HRA PF11786.8 ETS61577.1 - 5.4e-27 93.9 11.7 5.4e-27 93.9 11.7 3.5 3 0 0 3 3 3 1 Aft1 HRA domain bZIP_1 PF00170.21 ETS61577.1 - 3.7e-10 39.7 7.6 7.2e-10 38.8 7.6 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ETS61577.1 - 3.7e-06 26.9 8.6 9.5e-06 25.6 8.6 1.7 1 0 0 1 1 1 1 Basic region leucine zipper Aft1_OSA PF11785.8 ETS61577.1 - 0.0011 19.4 2.9 0.0011 19.4 2.9 3.9 3 0 0 3 3 3 1 Aft1 osmotic stress response (OSM) domain bZIP_Maf PF03131.17 ETS61577.1 - 0.0013 19.2 5.5 0.0027 18.2 5.5 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor Nnf1 PF03980.14 ETS61577.1 - 0.071 13.5 0.8 0.2 12.0 0.8 1.8 1 0 0 1 1 1 0 Nnf1 HALZ PF02183.18 ETS61577.1 - 0.14 12.4 0.6 0.27 11.5 0.6 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper JAKMIP_CC3 PF16034.5 ETS61577.1 - 9.5 6.1 8.6 28 4.6 8.6 1.8 1 1 0 1 1 1 0 JAKMIP CC3 domain Sugar_tr PF00083.24 ETS61578.1 - 1.4e-101 340.6 21.1 1.7e-101 340.3 21.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS61578.1 - 7.4e-33 113.9 46.0 1e-27 97.0 19.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Endotoxin_C2 PF18449.1 ETS61578.1 - 0.0019 18.5 0.0 0.0035 17.6 0.0 1.4 1 0 0 1 1 1 1 Delta endotoxin OATP PF03137.20 ETS61578.1 - 0.0056 15.0 1.8 0.0056 15.0 1.8 1.7 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF697 PF05128.12 ETS61578.1 - 0.071 12.8 0.1 0.19 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF697) TRI12 PF06609.13 ETS61578.1 - 0.13 10.7 9.6 0.028 12.8 1.0 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) Transketolase_N PF00456.21 ETS61579.1 - 7.3e-120 399.9 0.5 1.1e-119 399.4 0.5 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ETS61579.1 - 4.6e-42 143.7 0.1 1.2e-41 142.3 0.1 1.7 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ETS61579.1 - 5.3e-08 32.8 0.0 3e-07 30.4 0.0 2.3 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ETS61579.1 - 7.5e-05 22.1 0.0 0.00015 21.1 0.0 1.5 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 ETS61579.1 - 0.00021 20.3 0.1 0.00034 19.6 0.1 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 ETS61579.1 - 0.0059 16.4 0.9 0.03 14.1 0.9 2.2 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain HPTransfase PF10090.9 ETS61579.1 - 0.071 12.9 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphotransferase C-terminal domain DUF2280 PF10045.9 ETS61579.1 - 0.14 12.5 0.7 0.29 11.4 0.7 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2280) adh_short_C2 PF13561.6 ETS61580.1 - 4.2e-53 180.3 1.3 6.4e-53 179.7 1.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS61580.1 - 9.4e-42 142.7 1.3 1.3e-41 142.2 1.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS61580.1 - 1e-13 51.6 1.2 1.6e-13 50.9 1.2 1.3 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ETS61580.1 - 0.0016 17.9 0.0 0.0026 17.2 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETS61580.1 - 0.002 17.6 0.6 0.0063 16.0 0.6 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ETS61580.1 - 0.0046 16.1 0.0 0.0073 15.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ETS61580.1 - 0.0047 16.0 0.0 0.011 14.7 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Pyr_redox PF00070.27 ETS61580.1 - 0.082 13.5 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Cu-oxidase_3 PF07732.15 ETS61581.1 - 3.3e-34 117.4 2.4 8e-20 71.0 0.4 3.8 4 0 0 4 4 4 3 Multicopper oxidase Cu-oxidase PF00394.22 ETS61581.1 - 8.5e-33 113.7 0.0 5.6e-30 104.6 0.0 2.6 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ETS61581.1 - 3.2e-30 104.6 9.1 2.2e-29 102.0 2.5 3.6 4 0 0 4 4 4 1 Multicopper oxidase Phosphoesterase PF04185.14 ETS61582.1 - 1.9e-76 257.6 4.3 2.4e-76 257.3 3.8 1.3 1 1 0 1 1 1 1 Phosphoesterase family DAO PF01266.24 ETS61583.1 - 2.5e-34 119.4 4.1 2.9e-34 119.2 4.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS61583.1 - 2.1e-06 27.2 0.1 0.0081 15.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 ETS61583.1 - 0.00037 20.8 0.2 0.0014 18.9 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 ETS61583.1 - 0.003 16.9 0.1 0.0057 16.0 0.1 1.4 1 0 0 1 1 1 1 ThiF family NAD_binding_8 PF13450.6 ETS61583.1 - 0.0099 16.1 0.1 0.025 14.8 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Ldh_1_N PF00056.23 ETS61583.1 - 0.013 15.6 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NAD_binding_9 PF13454.6 ETS61583.1 - 0.019 15.0 2.1 1.1 9.2 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 ETS61583.1 - 0.021 13.9 0.7 1.1 8.3 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein ApbA PF02558.16 ETS61583.1 - 0.044 13.4 0.1 0.097 12.3 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Amino_oxidase PF01593.24 ETS61583.1 - 0.071 12.4 0.0 0.094 12.0 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 ETS61583.1 - 0.11 11.8 0.2 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 ETS61583.1 - 0.12 11.2 0.1 6.6 5.5 0.0 2.6 3 0 0 3 3 3 0 Tryptophan halogenase TrkA_N PF02254.18 ETS61583.1 - 0.16 12.2 0.1 0.38 11.0 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 ETS61583.1 - 0.2 11.7 0.0 0.38 10.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase TAL_FSA PF00923.19 ETS61584.1 - 2.5e-28 99.3 0.0 3.5e-28 98.8 0.0 1.4 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Hydrolase_4 PF12146.8 ETS61585.1 - 3.9e-10 39.4 2.5 3.5e-08 33.0 2.5 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS61585.1 - 4.8e-10 39.5 1.7 5.3e-08 32.8 0.4 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS61585.1 - 1.7e-07 32.1 4.6 1.7e-07 32.1 4.6 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase family DUF1749 PF08538.10 ETS61585.1 - 6.3e-05 22.2 0.0 0.00045 19.4 0.0 2.2 2 1 0 3 3 3 1 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.21 ETS61585.1 - 0.00013 21.6 0.1 0.0004 19.9 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Cupin_3 PF05899.12 ETS61585.1 - 0.00017 21.2 0.1 0.12 12.1 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Cupin_2 PF07883.11 ETS61585.1 - 0.00043 19.9 0.3 0.25 11.1 0.0 3.1 3 0 0 3 3 3 1 Cupin domain Cupin_8 PF13621.6 ETS61585.1 - 0.06 13.1 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Cupin-like domain Peptidase_S15 PF02129.18 ETS61585.1 - 0.067 12.8 0.1 1.2 8.7 0.1 2.2 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Tannase PF07519.11 ETS61585.1 - 0.091 11.6 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Tannase and feruloyl esterase PMI_typeI PF01238.21 ETS61585.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.3 1 0 0 1 1 1 0 Phosphomannose isomerase type I Peptidase_M28 PF04389.17 ETS61586.1 - 3.2e-41 141.2 0.1 5.4e-41 140.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ETS61586.1 - 1.8e-13 50.3 0.8 1.8e-13 50.3 0.8 1.9 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 ETS61586.1 - 0.00017 21.4 0.2 0.00035 20.3 0.1 1.6 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 ETS61586.1 - 0.018 14.1 0.1 0.25 10.3 0.0 2.1 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase DUF3425 PF11905.8 ETS61587.1 - 1.1e-16 61.0 0.0 2.2e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ETS61587.1 - 0.0017 18.4 12.4 0.0028 17.7 12.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 ETS61587.1 - 0.015 15.8 11.8 0.026 15.0 11.8 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor bZIP_2 PF07716.15 ETS61587.1 - 0.24 11.5 14.4 0.44 10.7 14.4 1.3 1 0 0 1 1 1 0 Basic region leucine zipper DJ-1_PfpI PF01965.24 ETS61588.1 - 2.8e-05 24.0 0.0 0.00011 22.0 0.0 1.9 2 1 0 2 2 2 1 DJ-1/PfpI family RVT_1 PF00078.27 ETS61589.1 - 1.2e-05 25.0 0.0 2.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-C3HC4 PF00097.25 ETS61591.1 - 1.1e-08 34.8 9.8 1.1e-08 34.8 9.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS61591.1 - 1.2e-08 34.6 10.4 5.6e-08 32.5 7.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ETS61591.1 - 4.3e-07 29.7 7.3 1.1e-06 28.4 5.3 2.5 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 ETS61591.1 - 1e-06 28.6 12.5 1.9e-06 27.8 7.1 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETS61591.1 - 1.5e-05 25.2 14.6 3.7e-05 24.0 8.8 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 ETS61591.1 - 2.2e-05 24.5 9.1 2.2e-05 24.5 9.1 2.3 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ETS61591.1 - 2.7e-05 24.1 13.8 5.6e-05 23.0 9.8 2.3 2 0 0 2 2 2 1 zinc-RING finger domain SAP PF02037.27 ETS61591.1 - 4.8e-05 23.0 2.1 5.4e-05 22.8 0.1 2.2 3 0 0 3 3 2 1 SAP domain zf-ANAPC11 PF12861.7 ETS61591.1 - 0.0011 19.0 6.6 0.0021 18.1 3.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Actin_micro PF17003.5 ETS61591.1 - 0.0027 16.9 0.0 0.0045 16.2 0.0 1.3 1 0 0 1 1 1 1 Putative actin-like family zf-C2HC_2 PF13913.6 ETS61591.1 - 0.0027 17.5 0.1 0.0027 17.5 0.1 2.3 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C3HC4_3 PF13920.6 ETS61591.1 - 0.006 16.4 13.4 0.014 15.3 10.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 ETS61591.1 - 0.02 14.7 5.1 0.02 14.7 5.1 2.4 2 1 1 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_10 PF16685.5 ETS61591.1 - 0.022 14.9 4.2 0.056 13.6 4.2 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 ETS61591.1 - 0.032 14.1 13.4 1.5 8.7 10.0 2.6 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Cys_rich_KTR PF14205.6 ETS61591.1 - 0.076 12.8 0.9 2.3 8.1 0.4 2.5 2 0 0 2 2 2 0 Cysteine-rich KTR zf-rbx1 PF12678.7 ETS61591.1 - 0.13 12.6 12.0 0.15 12.3 7.0 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-C2H2_4 PF13894.6 ETS61591.1 - 0.37 11.7 0.1 0.37 11.7 0.1 4.0 3 1 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 ETS61591.1 - 0.6 10.5 6.1 0.32 11.3 0.3 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding ANAPC1 PF12859.7 ETS61591.1 - 1.3 9.6 5.8 0.53 10.9 1.8 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 zf-RING_4 PF14570.6 ETS61591.1 - 1.3 8.8 12.5 1.2 9.0 8.8 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain LysM PF01476.20 ETS61592.1 - 0.0011 19.0 0.0 0.0023 18.0 0.0 1.6 1 0 0 1 1 1 1 LysM domain ATP-synt PF00231.19 ETS61594.1 - 4.1e-76 256.4 7.1 4.7e-76 256.2 7.1 1.0 1 0 0 1 1 1 1 ATP synthase eIF-5_eIF-2B PF01873.17 ETS61595.1 - 3.1e-42 143.2 0.2 4.7e-42 142.6 0.2 1.2 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 ETS61595.1 - 0.011 15.3 0.2 0.02 14.4 0.2 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding zf_C2H2_13 PF18508.1 ETS61595.1 - 0.69 9.5 3.7 2.4 7.8 0.3 2.2 1 1 1 2 2 2 0 Zinc finger domain NAD_kinase PF01513.21 ETS61596.1 - 0.12 11.5 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 ATP-NAD kinase ABC_membrane PF00664.23 ETS61597.1 - 5.1e-80 269.0 12.4 7.6e-44 150.4 1.8 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS61597.1 - 2.1e-60 203.2 0.0 5.5e-30 104.7 0.0 3.4 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ETS61597.1 - 1.9e-13 50.4 0.0 0.00082 18.9 0.0 4.3 4 0 0 4 4 4 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ETS61597.1 - 2.1e-08 34.3 0.0 0.00084 19.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase ABC_ATPase PF09818.9 ETS61597.1 - 1.5e-07 30.6 0.0 0.025 13.4 0.0 3.1 3 1 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 ETS61597.1 - 1.7e-07 30.9 0.3 0.0053 16.5 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ETS61597.1 - 1.4e-06 28.7 0.2 0.014 15.6 0.0 3.4 3 1 0 3 3 2 2 AAA domain AAA_15 PF13175.6 ETS61597.1 - 2.3e-06 27.6 0.0 0.08 12.6 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 ETS61597.1 - 2.7e-06 27.1 0.1 0.25 10.9 0.0 4.3 4 0 0 4 4 4 1 AAA domain AAA_16 PF13191.6 ETS61597.1 - 7.6e-06 26.4 0.8 0.075 13.4 0.0 3.5 2 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 ETS61597.1 - 2.4e-05 24.9 0.1 0.011 16.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETS61597.1 - 3.9e-05 24.2 0.0 0.15 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 ETS61597.1 - 6.4e-05 22.9 0.0 0.31 10.8 0.0 3.6 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ETS61597.1 - 0.00028 20.5 0.0 0.18 11.3 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_33 PF13671.6 ETS61597.1 - 0.0013 18.9 0.0 0.47 10.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 ETS61597.1 - 0.0068 16.6 1.8 3.6 7.9 0.3 3.5 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DLIC PF05783.11 ETS61597.1 - 0.0093 14.8 0.0 0.023 13.5 0.0 1.6 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) RNA_helicase PF00910.22 ETS61597.1 - 0.024 15.0 0.2 6.9 7.1 0.0 3.3 2 1 1 3 3 3 0 RNA helicase MMR_HSR1 PF01926.23 ETS61597.1 - 0.025 14.6 0.0 2.3 8.4 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF87 PF01935.17 ETS61597.1 - 0.038 14.1 0.2 3.1 7.8 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_30 PF13604.6 ETS61597.1 - 0.041 13.6 0.2 2.6 7.7 0.0 3.0 4 0 0 4 4 3 0 AAA domain Zeta_toxin PF06414.12 ETS61597.1 - 0.059 12.6 0.0 8.6 5.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin G-alpha PF00503.20 ETS61597.1 - 0.099 11.8 0.0 2.3 7.3 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_5 PF07728.14 ETS61597.1 - 0.11 12.5 0.0 3.4 7.7 0.0 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ETS61597.1 - 0.12 12.6 0.0 23 5.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain Asp PF00026.23 ETS61598.1 - 1.6e-27 96.7 0.0 1.9e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS61598.1 - 6.3e-09 36.3 0.8 6.7e-06 26.5 0.2 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS61598.1 - 0.053 14.2 0.5 0.19 12.4 0.0 2.2 3 0 0 3 3 3 0 Aspartyl protease Lactamase_B PF00753.27 ETS61599.1 - 0.0023 18.0 0.4 0.0042 17.1 0.4 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Sugar_tr PF00083.24 ETS61600.1 - 1.7e-115 386.4 23.5 2e-115 386.2 23.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS61600.1 - 6.1e-24 84.6 38.7 4.8e-17 61.9 9.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 ETS61600.1 - 4.9 5.3 9.2 9.8 4.3 9.2 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) RPEL PF02755.15 ETS61601.1 - 5e-28 95.9 41.3 2.6e-08 33.3 2.6 5.0 6 0 0 6 6 6 4 RPEL repeat Antimicrobial18 PF08130.11 ETS61601.1 - 0.00052 20.1 0.6 2.7 8.2 0.0 3.2 3 0 0 3 3 3 2 Type A lantibiotic family Post_transc_reg PF13797.6 ETS61601.1 - 0.011 15.6 0.2 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Post-transcriptional regulator Hanta_nucleocap PF00846.18 ETS61601.1 - 0.015 13.8 5.0 0.65 8.4 0.1 2.8 1 1 2 3 3 3 0 Hantavirus nucleocapsid protein DnaI_N PF07319.11 ETS61601.1 - 0.14 12.9 0.2 28 5.4 0.1 2.4 1 1 1 2 2 2 0 Primosomal protein DnaI N-terminus DnaB_C PF03796.15 ETS61601.1 - 4.3 6.6 6.5 25 4.1 0.2 2.9 1 1 1 3 3 3 0 DnaB-like helicase C terminal domain NDUF_B12 PF08122.12 ETS61602.1 - 1.1e-18 66.9 0.3 1.4e-18 66.7 0.3 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family ATP-sulfurylase PF01747.17 ETS61603.1 - 3.4e-88 294.7 0.1 5.5e-88 294.0 0.1 1.3 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 ETS61603.1 - 7.6e-55 185.1 0.0 1.1e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 ETS61603.1 - 2.1e-53 180.3 0.0 3.2e-53 179.7 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Mito_carr PF00153.27 ETS61604.1 - 3.9e-44 148.5 8.8 1.1e-17 63.7 0.5 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Med12 PF09497.10 ETS61605.1 - 2.7e-32 110.8 0.1 1.5e-31 108.5 0.0 2.3 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 ETS61605.1 - 2.3e-05 23.4 0.0 4.1e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic Mediator 12 subunit domain tRNA-synt_1 PF00133.22 ETS61606.1 - 3.6e-35 121.3 0.0 7.4e-27 93.9 0.0 3.0 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETS61606.1 - 3.7e-16 58.9 0.0 2.2e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ETS61606.1 - 2.7e-13 50.2 0.0 6.3e-13 48.9 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ETS61606.1 - 2.2e-06 27.2 0.0 6.5e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Peptidase_M14 PF00246.24 ETS61607.1 - 7.4e-65 219.6 0.0 1.3e-64 218.8 0.0 1.4 1 0 0 1 1 1 1 Zinc carboxypeptidase ACP_PD PF04336.12 ETS61607.1 - 0.038 14.4 1.3 0.071 13.5 1.3 1.4 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase WD40 PF00400.32 ETS61608.1 - 5.3e-59 194.8 15.9 0.00012 22.7 0.0 12.9 13 0 0 13 13 13 11 WD domain, G-beta repeat Utp13 PF08625.11 ETS61608.1 - 1.1e-46 158.3 0.4 2.2e-46 157.3 0.4 1.6 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 ETS61608.1 - 4.2e-11 43.0 2.2 0.17 12.2 0.0 7.9 4 3 3 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS61608.1 - 4.1e-05 22.4 5.7 3.5 6.2 0.0 6.5 5 1 0 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETS61608.1 - 0.00014 21.3 0.0 0.23 10.8 0.0 3.2 3 0 0 3 3 3 2 WD40-like domain Hira PF07569.11 ETS61608.1 - 0.0034 17.1 2.1 37 4.0 0.0 5.2 4 1 1 5 5 5 0 TUP1-like enhancer of split SLX9 PF15341.6 ETS61608.1 - 0.0072 16.7 1.7 0.0072 16.7 1.7 2.2 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 tRNA-synt_1b PF00579.25 ETS61609.1 - 2.1e-69 234.1 0.0 2.9e-69 233.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 ETS61609.1 - 4.4e-05 23.3 0.2 0.00075 19.3 0.2 2.3 1 1 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain S4 PF01479.25 ETS61609.1 - 0.0021 17.7 0.0 0.0048 16.6 0.0 1.6 1 0 0 1 1 1 1 S4 domain HTH_IclR PF09339.10 ETS61609.1 - 0.95 9.3 5.4 0.26 11.1 0.2 2.8 3 0 0 3 3 3 0 IclR helix-turn-helix domain ABC_membrane PF00664.23 ETS61610.1 - 1.2e-93 313.8 23.0 3.7e-49 167.8 6.3 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS61610.1 - 1e-61 207.5 0.0 1.2e-31 110.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ETS61610.1 - 1.5e-13 50.7 0.1 0.00018 21.0 0.0 4.0 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain Zeta_toxin PF06414.12 ETS61610.1 - 8e-07 28.5 0.0 0.029 13.7 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_22 PF13401.6 ETS61610.1 - 4.2e-06 27.1 1.3 1.1 9.5 0.0 4.2 4 0 0 4 4 4 2 AAA domain ABC_ATPase PF09818.9 ETS61610.1 - 1.7e-05 23.9 0.2 0.0056 15.5 0.0 2.3 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_25 PF13481.6 ETS61610.1 - 1.7e-05 24.5 0.4 0.56 9.7 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_30 PF13604.6 ETS61610.1 - 4e-05 23.4 0.4 0.21 11.3 0.0 3.6 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 ETS61610.1 - 7.4e-05 22.4 0.3 0.47 10.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ETS61610.1 - 0.00015 22.2 6.0 0.1 13.0 0.6 3.4 3 1 0 3 3 2 2 AAA ATPase domain AAA_21 PF13304.6 ETS61610.1 - 0.0003 20.7 0.0 2.4 7.9 0.0 3.7 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 ETS61610.1 - 0.00066 19.8 0.4 0.66 10.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain G-alpha PF00503.20 ETS61610.1 - 0.0031 16.7 0.0 1.2 8.2 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit RsgA_GTPase PF03193.16 ETS61610.1 - 0.0036 17.2 0.0 2 8.3 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase APS_kinase PF01583.20 ETS61610.1 - 0.0051 16.7 0.1 0.094 12.6 0.0 2.3 2 0 0 2 2 2 1 Adenylylsulphate kinase SRP54 PF00448.22 ETS61610.1 - 0.0068 16.1 0.0 0.83 9.2 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Mg_chelatase PF01078.21 ETS61610.1 - 0.014 14.8 0.1 0.061 12.7 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_15 PF13175.6 ETS61610.1 - 0.015 15.0 0.0 0.99 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain DEAD PF00270.29 ETS61610.1 - 0.019 14.7 0.7 0.71 9.6 0.1 2.9 3 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_18 PF13238.6 ETS61610.1 - 0.029 14.9 0.0 0.78 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ETS61610.1 - 0.032 14.5 10.0 1.7 8.9 0.7 5.1 3 3 0 3 3 3 0 Putative exonuclease SbcCD, C subunit Semialdhyde_dhC PF02774.18 ETS61610.1 - 0.048 13.7 0.1 5.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain AAA_24 PF13479.6 ETS61610.1 - 0.05 13.3 0.2 9.2 5.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 ETS61610.1 - 0.054 13.9 0.1 7.3 7.0 0.0 2.9 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ETS61610.1 - 0.097 12.7 3.2 1.9 8.5 0.1 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_5 PF07728.14 ETS61610.1 - 0.11 12.5 0.3 2.3 8.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) PRK PF00485.18 ETS61610.1 - 0.17 11.6 0.2 16 5.1 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF1635 PF07795.11 ETS61610.1 - 0.17 11.7 3.5 0.4 10.5 3.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) NB-ARC PF00931.22 ETS61610.1 - 0.21 10.7 0.2 19 4.3 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain DLIC PF05783.11 ETS61610.1 - 1.3 7.8 5.7 17 4.1 0.0 2.6 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) SfLAP PF11139.8 ETS61610.1 - 6.6 6.1 12.8 0.3 10.5 4.4 2.5 2 0 0 2 2 2 0 Sap, sulfolipid-1-addressing protein LRR_8 PF13855.6 ETS61611.1 - 5.5e-14 51.7 10.5 8.2e-11 41.5 8.5 2.8 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ETS61611.1 - 2.2e-10 40.6 18.2 5.1e-05 23.5 3.9 4.7 3 2 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETS61611.1 - 1.3 9.8 16.7 2.8 8.8 0.3 5.1 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_9 PF14580.6 ETS61611.1 - 1.5 8.3 4.7 1.3 8.5 1.8 2.2 2 1 1 3 3 3 0 Leucine-rich repeat Pox_A_type_inc PF04508.12 ETS61611.1 - 5.6 7.0 6.1 41 4.3 0.2 3.3 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat EF_TS PF00889.19 ETS61612.1 - 9.9e-14 51.4 0.0 7.5e-13 48.6 0.0 2.3 3 0 0 3 3 3 1 Elongation factor TS POT1PC PF16686.5 ETS61613.1 - 3.4e-19 69.3 0.0 2.1e-16 60.1 0.0 2.6 2 1 0 2 2 2 2 ssDNA-binding domain of telomere protection protein POT1 PF02765.17 ETS61613.1 - 7.9e-11 42.0 0.0 1.7e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 DZR PF12773.7 ETS61613.1 - 0.006 16.6 1.2 0.012 15.6 1.2 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 ETS61613.1 - 0.034 14.9 0.1 0.059 14.1 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon family UPF0547 PF10571.9 ETS61613.1 - 0.26 11.4 1.9 0.86 9.7 1.9 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Hamartin PF04388.12 ETS61614.1 - 2.1e-09 36.7 28.3 2.1e-09 36.7 28.3 5.1 2 1 0 2 2 2 1 Hamartin protein bZIP_1 PF00170.21 ETS61614.1 - 0.79 9.9 17.3 0.27 11.4 1.1 4.0 4 0 0 4 4 4 0 bZIP transcription factor BLOC1_2 PF10046.9 ETS61614.1 - 0.9 9.9 18.8 0.28 11.5 2.7 3.7 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SNCAIP_SNCA_bd PF16700.5 ETS61614.1 - 1.2 8.9 3.6 28 4.6 0.3 2.9 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain TSC22 PF01166.18 ETS61614.1 - 2.1 8.7 9.8 8.1 6.8 0.4 4.1 3 0 0 3 3 3 0 TSC-22/dip/bun family Sec34 PF04136.15 ETS61614.1 - 2.2 8.1 8.1 2.4 8.1 2.1 2.8 2 0 0 2 2 2 0 Sec34-like family DUF948 PF06103.11 ETS61614.1 - 3.4 8.0 6.0 71 3.8 1.9 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Nsp1_C PF05064.13 ETS61614.1 - 4.2 7.2 13.7 1.4 8.7 3.7 2.9 1 1 1 2 2 2 0 Nsp1-like C-terminal region Sulfatase_C PF14707.6 ETS61614.1 - 6.1 7.6 6.3 1.3e+02 3.3 2.5 3.5 2 1 0 2 2 2 0 C-terminal region of aryl-sulfatase NPV_P10 PF05531.12 ETS61614.1 - 7.7 7.1 6.8 22 5.6 0.2 3.6 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF724 PF05266.14 ETS61614.1 - 8.2 6.2 27.2 1.5 8.7 5.6 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF724) Sugar_tr PF00083.24 ETS61615.1 - 3.4e-36 125.1 22.1 2.1e-34 119.2 22.1 2.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS61615.1 - 2.2e-30 105.8 31.3 2.2e-30 105.8 31.3 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily tRNA-synt_2 PF00152.20 ETS61617.1 - 5.1e-75 252.5 0.0 6.4e-75 252.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ETS61617.1 - 1e-11 44.6 0.0 2.2e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ETS61617.1 - 3.7e-08 33.2 0.0 0.00013 21.6 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) DLEU7 PF15760.5 ETS61617.1 - 0.16 11.5 1.7 0.26 10.7 1.7 1.3 1 0 0 1 1 1 0 Leukemia-associated protein 7 Aldo_ket_red PF00248.21 ETS61618.1 - 7.4e-35 120.6 0.0 3e-33 115.3 0.0 2.6 1 1 0 1 1 1 1 Aldo/keto reductase family WAK PF08488.11 ETS61618.1 - 0.013 16.1 0.1 0.029 14.9 0.1 1.6 1 0 0 1 1 1 0 Wall-associated kinase X PF00739.19 ETS61618.1 - 0.055 13.6 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 Trans-activation protein X Pyridoxal_deC PF00282.19 ETS61619.1 - 2.4e-20 72.6 0.0 4.4e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ETS61619.1 - 7.5e-07 28.4 0.0 1.6e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ETS61619.1 - 0.011 15.1 0.1 0.02 14.2 0.1 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 ETS61619.1 - 0.028 12.9 0.0 0.054 12.0 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ETS61619.1 - 0.17 11.1 0.0 0.32 10.1 0.0 1.5 1 0 0 1 1 1 0 Aminotransferase class I and II tRNA-synt_1c PF00749.21 ETS61621.1 - 3.7e-107 357.9 0.0 5e-107 357.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 ETS61621.1 - 3.5e-43 147.4 0.0 5.9e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 ETS61621.1 - 1.2e-33 116.4 0.0 4.2e-33 114.7 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 ETS61621.1 - 6.4e-06 27.0 0.6 6.4e-06 27.0 0.6 3.0 3 0 0 3 3 3 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 CDC73_C PF05179.14 ETS61622.1 - 6.7e-54 181.8 0.1 1.1e-53 181.1 0.1 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 ETS61622.1 - 0.00021 20.7 0.0 0.00036 20.0 0.0 1.4 1 0 0 1 1 1 1 Paf1 complex subunit CDC73 N-terminal Tim17 PF02466.19 ETS61622.1 - 0.36 11.2 2.5 7.3 7.0 0.0 2.5 1 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family INTAP PF16617.5 ETS61622.1 - 1.7 9.1 5.4 1.1 9.6 2.5 2.3 2 1 0 2 2 2 0 Intersectin and clathrin adaptor AP2 binding region Ost5 PF05251.12 ETS61623.1 - 8.4e-19 67.6 8.9 1.1e-18 67.2 8.9 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 PEPCK_ATP PF01293.20 ETS61624.1 - 9.2e-222 736.7 0.0 1.1e-221 736.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 ETS61624.1 - 0.18 11.9 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AMP-binding PF00501.28 ETS61625.1 - 4.1e-47 160.7 0.0 5.7e-47 160.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 ETS61625.1 - 2.6e-09 36.9 1.0 2.6e-09 36.9 1.0 1.7 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ETS61625.1 - 4.9e-05 24.2 0.1 0.00011 23.1 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Na_Ca_ex PF01699.24 ETS61626.1 - 1.9e-34 118.8 50.3 4.2e-18 65.8 22.4 2.9 2 1 1 3 3 3 2 Sodium/calcium exchanger protein Glyco_transf_22 PF03901.17 ETS61626.1 - 0.012 14.9 0.4 0.012 14.9 0.4 3.7 2 2 1 3 3 3 0 Alg9-like mannosyltransferase family DUF3784 PF12650.7 ETS61626.1 - 0.42 10.8 0.0 0.42 10.8 0.0 4.6 4 1 2 6 6 6 0 Domain of unknown function (DUF3784) DUF3684 PF12449.8 ETS61627.1 - 0 1231.8 0.0 0 1231.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3684) MPC PF03650.13 ETS61628.1 - 2e-36 124.5 0.1 2.3e-36 124.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Zn_clus PF00172.18 ETS61629.1 - 3.6e-08 33.4 11.1 6.8e-08 32.5 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS61629.1 - 0.025 13.6 0.7 0.3 10.1 0.2 2.7 2 1 0 2 2 2 0 Fungal specific transcription factor domain IL11 PF07400.11 ETS61629.1 - 1.5 8.5 3.7 4.7 6.8 0.6 2.4 2 0 0 2 2 2 0 Interleukin 11 Ribosomal_S2 PF00318.20 ETS61630.1 - 3.8e-27 94.9 0.0 1.7e-12 47.0 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 ETS61630.1 - 1.7e-08 35.7 16.0 3.3e-08 34.8 16.0 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus MUG113 PF13455.6 ETS61631.1 - 5.4e-15 55.8 0.0 1.2e-14 54.7 0.0 1.6 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 T5orf172 PF10544.9 ETS61631.1 - 1.2e-12 48.3 0.0 3.3e-12 46.9 0.0 1.9 1 0 0 1 1 1 1 T5orf172 domain Ribosomal_S5 PF00333.20 ETS61632.1 - 5.5e-27 93.5 2.1 6.5e-27 93.3 0.9 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ETS61632.1 - 1.7e-22 78.7 0.1 3.1e-22 77.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain F1F0-ATPsyn_F PF10791.9 ETS61633.1 - 1.5e-29 102.3 0.0 1.9e-29 102.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi IMS PF00817.20 ETS61634.1 - 2.7e-45 154.0 0.1 5.1e-45 153.1 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ETS61634.1 - 5.2e-13 49.7 2.1 2.2e-12 47.7 2.2 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ETS61634.1 - 3.9e-06 26.9 0.0 9.6e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif RNF220 PF15926.5 ETS61634.1 - 0.045 13.4 1.3 0.048 13.3 0.0 1.7 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 Peptidase_C54 PF03416.19 ETS61635.1 - 7.1e-102 340.5 0.0 1.1e-101 339.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C54 NAP PF00956.18 ETS61636.1 - 1.6e-97 326.0 4.2 2.4e-97 325.3 4.2 1.3 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Acetyltransf_1 PF00583.25 ETS61638.1 - 2e-05 24.8 0.0 0.021 15.0 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS61638.1 - 2.6e-05 24.6 0.0 0.0047 17.3 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS61638.1 - 0.00011 22.2 0.1 0.03 14.2 0.0 2.5 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS61638.1 - 0.031 14.2 0.1 5.2 7.1 0.1 3.0 3 0 0 3 3 3 0 FR47-like protein Ribosomal_L39 PF00832.20 ETS61639.1 - 2.8e-10 39.7 11.2 4.1e-08 32.7 1.7 2.4 2 0 0 2 2 2 2 Ribosomal L39 protein adh_short_C2 PF13561.6 ETS61640.1 - 5.1e-48 163.7 0.4 6.4e-48 163.4 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS61640.1 - 7.5e-35 120.2 0.0 9.8e-35 119.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS61640.1 - 6.2e-09 36.0 0.0 9.1e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETS61640.1 - 0.007 15.5 0.0 0.01 15.0 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein His_biosynth PF00977.21 ETS61640.1 - 0.021 14.3 0.0 0.048 13.1 0.0 1.6 1 1 0 1 1 1 0 Histidine biosynthesis protein Cbl_N3 PF02762.14 ETS61640.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Ku PF02735.16 ETS61641.1 - 2.3e-45 154.8 0.0 3.9e-45 154.1 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ETS61641.1 - 2e-16 60.4 0.0 9.3e-16 58.2 0.0 2.1 2 1 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 ETS61641.1 - 2.1e-14 54.0 0.1 6.8e-14 52.3 0.1 1.9 1 0 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 ETS61641.1 - 1.3e-07 31.2 0.0 2.8e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 SAP domain VWA_2 PF13519.6 ETS61641.1 - 0.0068 17.0 0.0 0.12 13.0 0.0 2.5 2 0 0 2 2 2 1 von Willebrand factor type A domain VHS PF00790.19 ETS61641.1 - 0.096 12.5 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 VHS domain Abhydrolase_3 PF07859.13 ETS61642.1 - 4.1e-30 105.2 0.2 5.6e-30 104.8 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 ETS61642.1 - 0.00081 19.1 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETS61642.1 - 0.0012 18.4 0.0 0.009 15.5 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family DLH PF01738.18 ETS61642.1 - 0.0021 17.6 0.1 0.17 11.4 0.0 2.5 2 1 0 2 2 2 1 Dienelactone hydrolase family Thioesterase PF00975.20 ETS61642.1 - 0.0045 17.1 0.0 0.0071 16.5 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain BAAT_C PF08840.11 ETS61642.1 - 0.066 13.1 0.0 0.5 10.3 0.0 2.3 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 ETS61642.1 - 0.1 12.2 0.0 0.22 11.0 0.0 1.5 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 ETS61642.1 - 0.13 11.8 0.0 0.48 10.0 0.0 1.9 2 1 0 2 2 2 0 alpha/beta hydrolase fold Glyco_transf_90 PF05686.12 ETS61643.1 - 1.1e-17 64.1 0.0 1.8e-16 60.1 0.0 2.4 2 1 0 2 2 2 1 Glycosyl transferase family 90 RabGAP-TBC PF00566.18 ETS61644.1 - 5e-49 166.9 0.0 6.6e-49 166.5 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SH3_1 PF00018.28 ETS61644.1 - 0.0062 16.1 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETS61644.1 - 0.074 12.7 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Variant SH3 domain FSA_C PF10479.9 ETS61644.1 - 3.5 5.7 9.5 6.2 4.8 9.5 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mannosyl_trans3 PF11051.8 ETS61646.1 - 2.8e-39 135.1 0.0 4.8e-39 134.4 0.0 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Mannosyl_trans3 PF11051.8 ETS61647.1 - 4.2e-30 105.0 0.0 6.6e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative Dickkopf_N PF04706.12 ETS61648.1 - 1.6e-07 31.7 71.8 0.0017 18.8 15.1 5.3 4 1 1 5 5 5 4 Dickkopf N-terminal cysteine-rich region EB PF01683.18 ETS61648.1 - 0.00084 19.6 79.1 1.3 9.4 17.6 6.9 1 1 6 7 7 7 7 EB module UPF0506 PF11703.8 ETS61648.1 - 0.005 17.2 66.7 0.036 14.4 12.4 4.9 4 2 0 4 4 4 3 UPF0506 Rep_fac-A_C PF08646.10 ETS61649.1 - 2.8e-58 195.8 4.1 1.1e-56 190.6 0.4 2.2 2 0 0 2 2 2 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ETS61649.1 - 5.2e-36 122.5 0.0 4.3e-35 119.6 0.0 2.2 2 0 0 2 2 2 1 Replication protein A OB domain Rep-A_N PF04057.12 ETS61649.1 - 8.8e-26 89.9 0.3 2.1e-25 88.7 0.3 1.7 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 ETS61649.1 - 3.5e-12 46.1 0.1 5.6e-10 39.1 0.0 3.4 4 0 0 4 4 4 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 ETS61649.1 - 0.00083 19.1 0.1 0.016 14.9 0.0 2.2 2 0 0 2 2 2 1 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 ETS61649.1 - 0.012 15.9 0.2 0.033 14.5 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF223 DUF5521 PF17659.1 ETS61649.1 - 0.12 10.1 0.4 0.23 9.3 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5521) DUF4539 PF15072.6 ETS61649.1 - 0.14 12.2 0.0 0.51 10.4 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) DZR PF12773.7 ETS61650.1 - 0.00077 19.4 19.3 0.015 15.3 0.8 2.9 1 1 1 3 3 3 2 Double zinc ribbon zf-RING_9 PF13901.6 ETS61650.1 - 0.0034 17.4 4.7 0.0056 16.7 4.7 1.3 1 0 0 1 1 1 1 Putative zinc-RING and/or ribbon zf-C3HC4_3 PF13920.6 ETS61650.1 - 1.3 9.0 17.1 1.7 8.6 4.2 3.4 1 1 2 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Rhodanese_C PF12368.8 ETS61650.1 - 6.1 7.3 16.3 7 7.1 9.8 2.7 1 1 1 2 2 2 0 Rhodanase C-terminal zf-C2H2_jaz PF12171.8 ETS61651.1 - 1.7e-05 25.0 0.0 2.7e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding SNRNP27 PF08648.12 ETS61651.1 - 0.00011 22.2 0.8 0.00029 20.8 0.8 1.8 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins zf-met PF12874.7 ETS61651.1 - 0.00013 22.2 0.2 0.00021 21.6 0.2 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SYCE1 PF15233.6 ETS61651.1 - 0.48 10.5 6.0 1.2 9.2 2.4 2.1 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 tRNA-synt_1 PF00133.22 ETS61652.1 - 8.2e-224 744.3 0.0 1e-223 744.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ETS61652.1 - 4.4e-22 78.7 0.0 8.8e-22 77.7 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ETS61652.1 - 8.3e-14 51.1 1.1 8.7e-05 21.4 0.2 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ETS61652.1 - 0.00066 19.1 0.0 0.0046 16.3 0.0 2.2 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Phosducin PF02114.16 ETS61653.1 - 3.1e-20 72.2 0.0 3.4e-19 68.8 0.0 2.2 1 1 0 1 1 1 1 Phosducin GREB1 PF15782.5 ETS61653.1 - 0.42 7.7 4.2 0.53 7.3 4.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GATase_5 PF13507.6 ETS61654.1 - 1.2e-92 309.7 0.0 1.8e-92 309.1 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 ETS61654.1 - 1.3e-39 135.8 3.8 8.9e-25 87.6 0.1 2.7 2 1 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_linker PF18072.1 ETS61654.1 - 1.7e-22 79.7 0.0 5.2e-22 78.1 0.0 1.9 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain AIRS PF00586.24 ETS61654.1 - 0.4 11.4 5.2 2.4 8.9 0.0 3.5 3 0 0 3 3 3 0 AIR synthase related protein, N-terminal domain zf-CCCH PF00642.24 ETS61655.1 - 2.2e-09 37.0 2.7 5.1e-09 35.8 2.7 1.7 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 ETS61655.1 - 3e-07 30.2 5.7 6e-07 29.2 5.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS61655.1 - 5e-06 26.4 9.0 8.6e-06 25.6 9.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS61655.1 - 7.5e-06 25.7 8.3 1.4e-05 24.8 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS61655.1 - 1.3e-05 25.2 7.6 2.4e-05 24.2 7.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf_CCCH_4 PF18345.1 ETS61655.1 - 1.7e-05 24.7 4.4 3.2e-05 23.8 4.4 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-RING_2 PF13639.6 ETS61655.1 - 7.3e-05 23.0 6.9 0.00014 22.1 6.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETS61655.1 - 0.00015 21.6 8.5 0.00028 20.7 8.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETS61655.1 - 0.00046 20.3 6.4 0.001 19.2 6.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-CCCH_4 PF18044.1 ETS61655.1 - 0.0032 17.2 2.9 0.0032 17.2 2.9 1.9 3 0 0 3 3 2 1 CCCH-type zinc finger zf-RING_10 PF16685.5 ETS61655.1 - 0.013 15.6 2.8 0.013 15.6 2.8 1.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 ETS61655.1 - 0.017 15.0 6.1 0.031 14.1 6.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RcsC PF09456.10 ETS61655.1 - 0.16 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) zf-Nse PF11789.8 ETS61655.1 - 0.21 11.5 2.4 0.39 10.6 2.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit K_oxygenase PF13434.6 ETS61656.1 - 1.3e-87 294.1 0.0 6.9e-87 291.8 0.0 1.9 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ETS61656.1 - 5.3e-05 23.3 0.4 0.0058 16.6 0.1 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 ETS61656.1 - 0.0029 16.9 0.0 0.019 14.2 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS61656.1 - 0.21 10.8 0.0 1.3 8.2 0.0 2.1 1 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AMP-binding PF00501.28 ETS61657.1 - 6.1e-223 740.0 0.0 1.1e-78 264.7 0.0 3.4 3 0 0 3 3 3 3 AMP-binding enzyme Condensation PF00668.20 ETS61657.1 - 6.7e-106 354.7 0.0 5.3e-30 104.5 0.0 4.4 4 0 0 4 4 4 4 Condensation domain PP-binding PF00550.25 ETS61657.1 - 4.6e-39 132.6 1.0 1.1e-09 38.5 0.0 5.2 4 0 0 4 4 4 4 Phosphopantetheine attachment site AMP-binding_C PF13193.6 ETS61657.1 - 2.2e-10 41.4 0.1 0.0024 18.8 0.0 4.0 3 0 0 3 3 3 3 AMP-binding enzyme C-terminal domain Transferase PF02458.15 ETS61657.1 - 0.0011 17.8 0.0 1.7 7.2 0.0 3.3 3 0 0 3 3 3 2 Transferase family Bromodomain PF00439.25 ETS61658.1 - 7.9e-26 90.0 0.1 1.6e-25 89.0 0.1 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 ETS61658.1 - 1.4e-07 31.7 0.0 2.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETS61658.1 - 2.4e-06 27.5 0.0 4.8e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS61658.1 - 0.00023 21.5 0.1 0.00044 20.6 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain zinc_ribbon_4 PF13717.6 ETS61658.1 - 0.21 11.6 0.0 0.45 10.5 0.0 1.6 1 0 0 1 1 1 0 zinc-ribbon domain BC10 PF06726.12 ETS61659.1 - 3.7e-18 65.5 8.1 7.4e-18 64.6 8.1 1.5 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 SNF2_N PF00176.23 ETS61660.1 - 5.9e-51 173.2 0.0 1e-50 172.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS61660.1 - 1.6e-15 57.4 0.3 5.4e-15 55.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS61660.1 - 6.1e-07 29.6 0.0 1.2e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ETS61660.1 - 8.8e-07 28.4 0.0 1.8e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase HHH_3 PF12836.7 ETS61660.1 - 0.055 13.7 0.0 0.19 12.0 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif 2-Hacid_dh_C PF02826.19 ETS61661.1 - 2.6e-46 157.2 0.0 3.7e-46 156.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETS61661.1 - 8e-21 74.1 0.0 1.1e-20 73.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Shikimate_DH PF01488.20 ETS61661.1 - 0.005 16.9 0.0 0.87 9.6 0.0 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase PIN_4 PF13638.6 ETS61663.1 - 6.8e-18 65.2 0.1 2.1e-17 63.7 0.1 1.9 1 0 0 1 1 1 1 PIN domain EST1_DNA_bind PF10373.9 ETS61663.1 - 8.1e-13 48.5 0.0 2.5e-12 46.8 0.0 1.9 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain PIN_9 PF18477.1 ETS61663.1 - 0.005 17.1 0.5 0.13 12.5 0.0 2.9 2 0 0 2 2 2 1 PIN like domain TPR_1 PF00515.28 ETS61664.1 - 3.4e-21 74.1 3.1 0.00017 21.3 0.0 7.0 6 0 0 6 6 6 5 Tetratricopeptide repeat DnaJ PF00226.31 ETS61664.1 - 7.5e-18 64.4 0.0 2.6e-17 62.7 0.0 2.0 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 ETS61664.1 - 8.7e-18 62.9 9.2 0.0031 17.5 0.1 7.3 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 ETS61664.1 - 1.2e-15 57.3 17.4 6.1e-08 32.7 1.4 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETS61664.1 - 2.5e-15 55.4 6.8 0.004 17.2 0.3 6.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETS61664.1 - 5.6e-14 52.4 24.7 9.3e-07 29.3 2.1 5.2 4 2 2 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETS61664.1 - 5.8e-12 45.4 21.0 0.0086 16.8 0.1 7.0 4 2 3 7 7 5 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETS61664.1 - 8.5e-11 42.3 17.9 1e-06 29.2 2.7 4.8 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETS61664.1 - 1.5e-09 37.4 0.4 0.014 15.1 0.1 5.3 3 2 2 5 5 5 2 TPR repeat TPR_17 PF13431.6 ETS61664.1 - 6.1e-09 35.7 13.9 0.026 14.9 0.1 5.6 7 0 0 7 7 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS61664.1 - 1.7e-07 31.4 9.4 0.00061 20.0 0.5 3.8 2 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ETS61664.1 - 1.2e-06 28.7 12.0 0.023 15.0 2.4 4.3 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETS61664.1 - 1.5e-05 24.7 8.9 2 8.6 0.0 6.0 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETS61664.1 - 2e-05 24.9 21.9 0.029 15.0 0.4 7.3 8 2 0 8 8 7 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETS61664.1 - 8.5e-05 22.6 2.6 11 6.1 0.0 5.2 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat PknG_TPR PF16918.5 ETS61664.1 - 0.0026 16.6 8.5 0.044 12.5 0.1 3.5 2 1 2 4 4 4 1 Protein kinase G tetratricopeptide repeat SHNi-TPR PF10516.9 ETS61664.1 - 0.0096 15.4 0.2 0.0096 15.4 0.2 2.7 3 0 0 3 3 3 1 SHNi-TPR TPR_20 PF14561.6 ETS61664.1 - 0.014 15.7 1.4 0.014 15.7 1.4 4.5 4 1 0 5 5 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 ETS61664.1 - 0.036 14.7 8.8 2.7 8.9 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETS61664.1 - 0.037 14.1 4.6 5.5 7.1 0.3 3.9 3 1 0 3 3 3 0 Domain of Unknown Function (DUF3856) BTAD PF03704.17 ETS61664.1 - 0.06 13.8 0.3 0.06 13.8 0.3 3.7 2 1 2 4 4 4 0 Bacterial transcriptional activator domain NARP1 PF12569.8 ETS61664.1 - 0.061 12.2 9.2 0.032 13.2 1.8 2.8 2 1 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF357 PF04010.13 ETS61664.1 - 0.12 12.5 0.5 5.1 7.2 0.1 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF357) Spectrin PF00435.21 ETS61664.1 - 0.55 10.7 10.7 1.6 9.3 1.9 4.2 3 2 0 3 3 3 0 Spectrin repeat DUF2431 PF10354.9 ETS61666.1 - 6.3e-41 140.4 0.0 6.4e-40 137.2 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) EMP70 PF02990.16 ETS61667.1 - 7e-193 642.0 1.0 7e-193 642.0 1.0 1.9 2 1 0 2 2 2 1 Endomembrane protein 70 Serinc PF03348.15 ETS61667.1 - 1.9e-155 518.0 5.2 1.9e-155 518.0 5.2 2.1 2 0 0 2 2 2 1 Serine incorporator (Serinc) SCIMP PF15050.6 ETS61667.1 - 4.5 7.7 4.8 22 5.5 1.5 2.9 2 0 0 2 2 2 0 SCIMP protein Sybindin PF04099.12 ETS61668.1 - 0.0015 18.4 0.0 0.019 14.9 0.0 2.1 2 0 0 2 2 2 1 Sybindin-like family SOG2 PF10428.9 ETS61668.1 - 0.19 10.9 10.0 0.25 10.5 10.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MDD_C PF18376.1 ETS61669.1 - 9.4e-71 237.4 0.0 1.3e-70 237.0 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 ETS61669.1 - 1.8e-07 31.3 2.2 4.7e-07 29.9 2.2 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain UreF PF01730.16 ETS61669.1 - 0.021 15.4 0.2 1.4 9.5 0.1 3.1 2 1 1 3 3 3 0 UreF Brix PF04427.18 ETS61670.1 - 1.9e-44 152.1 0.1 2.5e-44 151.7 0.1 1.2 1 0 0 1 1 1 1 Brix domain Nucleopor_Nup85 PF07575.13 ETS61670.1 - 0.034 12.7 0.0 0.042 12.4 0.0 1.1 1 0 0 1 1 1 0 Nup85 Nucleoporin HSF_DNA-bind PF00447.17 ETS61672.1 - 1.2e-33 115.6 0.8 6.5e-30 103.6 0.8 2.3 1 1 0 1 1 1 1 HSF-type DNA-binding DUF3439 PF11921.8 ETS61672.1 - 0.86 9.6 6.3 2.2 8.3 6.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TFIIA PF03153.13 ETS61673.1 - 3.7e-56 191.9 20.7 2.1e-35 123.5 17.3 2.0 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Tup_N PF08581.10 ETS61673.1 - 0.033 14.5 0.4 0.062 13.6 0.4 1.3 1 0 0 1 1 1 0 Tup N-terminal SPX PF03105.19 ETS61673.1 - 0.19 11.6 4.0 0.23 11.3 4.0 1.1 1 0 0 1 1 1 0 SPX domain BUD22 PF09073.10 ETS61673.1 - 0.21 10.9 11.4 0.24 10.7 11.4 1.2 1 0 0 1 1 1 0 BUD22 DUF2967 PF11179.8 ETS61673.1 - 0.33 9.0 9.7 0.4 8.7 9.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) SRP-alpha_N PF04086.13 ETS61673.1 - 8.4 6.2 14.1 11 5.9 13.4 1.5 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PWWP PF00855.17 ETS61674.1 - 3.5e-19 69.0 0.0 3.5e-19 69.0 0.0 2.8 3 1 0 3 3 3 1 PWWP domain Med26 PF08711.11 ETS61674.1 - 5e-08 32.8 0.0 1.2e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain CDC45 PF02724.14 ETS61674.1 - 0.31 9.3 14.8 0.49 8.6 14.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 ETS61674.1 - 0.36 8.9 10.8 0.51 8.4 10.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2052 PF09747.9 ETS61674.1 - 1.7 8.7 19.5 0.3 11.2 15.0 1.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) FAM76 PF16046.5 ETS61674.1 - 3.9 6.7 10.4 6.8 6.0 10.4 1.3 1 0 0 1 1 1 0 FAM76 protein PI3K_1B_p101 PF10486.9 ETS61674.1 - 4.1 5.0 6.5 5.1 4.8 6.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NOA36 PF06524.12 ETS61674.1 - 7.6 5.8 13.0 0.44 9.8 6.1 2.1 2 0 0 2 2 2 0 NOA36 protein Pam17 PF08566.10 ETS61675.1 - 0.0038 17.1 0.0 0.0074 16.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 PTN13_u3 PF16599.5 ETS61675.1 - 0.11 12.5 3.0 0.27 11.3 3.0 1.6 1 0 0 1 1 1 0 Unstructured linker region on PTN13 protein between PDZ TcdA_TcdB_pore PF12920.7 ETS61675.1 - 0.13 10.5 0.9 0.2 9.9 0.9 1.2 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain BRE1 PF08647.11 ETS61676.1 - 1.2e-23 82.9 6.9 1.2e-23 82.9 6.9 8.1 5 1 4 9 9 9 2 BRE1 E3 ubiquitin ligase zf-RING_5 PF14634.6 ETS61676.1 - 4.9e-06 26.4 13.3 8.9e-06 25.6 13.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETS61676.1 - 8.5e-06 25.5 13.3 1.4e-05 24.8 13.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS61676.1 - 2.4e-05 24.1 10.1 4.2e-05 23.3 10.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS61676.1 - 4.7e-05 23.1 11.7 7.9e-05 22.4 11.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS61676.1 - 0.00015 21.8 8.0 0.00027 20.9 8.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger Lebercilin PF15619.6 ETS61676.1 - 0.00087 19.0 15.6 0.00087 19.0 15.6 7.3 2 2 5 7 7 7 1 Ciliary protein causing Leber congenital amaurosis disease Prok-RING_4 PF14447.6 ETS61676.1 - 0.0021 17.9 8.0 0.0037 17.1 8.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 ETS61676.1 - 0.0021 17.9 3.0 0.0045 16.8 3.0 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Fez1 PF06818.15 ETS61676.1 - 0.0031 18.0 17.2 0.0031 18.0 17.2 5.1 1 1 4 5 5 5 2 Fez1 zf-RING_2 PF13639.6 ETS61676.1 - 0.015 15.6 11.3 0.024 15.0 11.3 1.4 1 0 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 ETS61676.1 - 0.022 15.0 6.4 0.046 14.0 6.4 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_5 PF17121.5 ETS61676.1 - 0.28 11.1 7.0 0.56 10.1 7.0 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.6 ETS61676.1 - 0.79 9.2 4.3 0.39 10.2 0.8 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Filament PF00038.21 ETS61676.1 - 1.4 8.5 85.1 0.36 10.4 16.3 6.3 2 1 2 5 5 5 0 Intermediate filament protein DZR PF12773.7 ETS61676.1 - 2 8.5 7.1 3.8 7.6 7.1 1.4 1 0 0 1 1 1 0 Double zinc ribbon PKcGMP_CC PF16808.5 ETS61676.1 - 2.3 8.2 20.2 0.15 12.0 0.3 6.1 6 0 0 6 6 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Vac_Fusion PF02346.16 ETS61676.1 - 4.3 7.0 7.0 3.3 7.4 0.2 3.9 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 DUF2730 PF10805.8 ETS61676.1 - 4.6 7.4 24.4 0.076 13.1 1.9 6.1 2 1 2 5 5 5 0 Protein of unknown function (DUF2730) zf-C3HC4_4 PF15227.6 ETS61676.1 - 4.6 7.5 8.6 8.4 6.6 8.6 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING RNA_pol_N PF01194.17 ETS61677.1 - 1.9e-29 101.7 0.3 2.4e-29 101.4 0.3 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit GPR15L PF15854.5 ETS61677.1 - 0.1 12.8 1.4 12 6.2 0.0 2.2 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 SecY PF00344.20 ETS61678.1 - 1.2e-73 248.1 6.4 1.5e-73 247.7 6.4 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 ETS61678.1 - 1.9e-17 62.8 0.2 6.7e-17 61.0 0.2 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p Claudin_3 PF06653.11 ETS61678.1 - 0.1 12.5 2.8 1.6 8.7 0.0 3.4 3 1 0 3 3 3 0 Tight junction protein, Claudin-like Ribosom_S12_S23 PF00164.25 ETS61679.1 - 1e-47 160.5 0.8 1.6e-47 159.8 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Sec63 PF02889.16 ETS61680.1 - 0.084 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Sec63 Brl domain Metallophos PF00149.28 ETS61682.1 - 4.5e-34 118.7 0.6 7.9e-34 118.0 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Mito_carr PF00153.27 ETS61682.1 - 6e-07 29.3 0.0 0.073 13.0 0.0 3.4 3 0 0 3 3 3 2 Mitochondrial carrier protein Rax2 PF12768.7 ETS61683.1 - 2.2e-41 141.7 1.1 2.1e-38 131.9 0.0 4.4 5 0 0 5 5 5 1 Cortical protein marker for cell polarity SH3_1 PF00018.28 ETS61683.1 - 2.7e-14 52.5 0.0 6.4e-14 51.3 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS61683.1 - 5.4e-12 45.4 0.1 4e-11 42.6 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 ETS61683.1 - 1.6e-06 27.7 0.0 4.3e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_10 PF17902.1 ETS61683.1 - 0.005 16.9 0.0 0.037 14.1 0.0 2.5 2 0 0 2 2 2 1 SH3 domain Kelch_6 PF13964.6 ETS61683.1 - 0.026 14.8 4.0 1.1 9.6 0.1 5.1 5 1 1 6 6 6 0 Kelch motif DUF1918 PF08940.11 ETS61683.1 - 0.027 14.1 0.1 0.15 11.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1918) hSH3 PF14603.6 ETS61683.1 - 0.053 14.0 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 Helically-extended SH3 domain NCU-G1 PF15065.6 ETS61683.1 - 0.54 9.2 3.0 0.98 8.3 3.0 1.4 1 0 0 1 1 1 0 Lysosomal transcription factor, NCU-G1 Kelch_3 PF13415.6 ETS61683.1 - 1.3 9.4 9.5 0.77 10.1 0.2 4.8 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF5122 PF17164.4 ETS61683.1 - 1.9 8.8 25.7 0.51 10.7 0.1 7.9 8 0 0 8 8 8 0 Domain of unknown function (DUF5122) beta-propeller HIT PF01230.23 ETS61685.1 - 6e-19 68.6 1.1 1e-18 67.9 0.4 1.6 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 ETS61685.1 - 3.7e-14 53.2 0.0 5.7e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ETS61685.1 - 6.2e-06 26.1 0.0 9.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 PIG-P PF08510.12 ETS61686.1 - 8.5e-33 112.8 1.5 1.2e-32 112.3 1.5 1.2 1 0 0 1 1 1 1 PIG-P CIA30 PF08547.12 ETS61686.1 - 1.3e-14 54.6 0.0 8.6e-09 35.6 0.0 2.2 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) DPM2 PF07297.12 ETS61686.1 - 0.015 15.5 3.7 0.028 14.7 3.7 1.4 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) HMMR_C PF15908.5 ETS61687.1 - 0.00019 21.7 5.5 0.00019 21.7 5.5 6.0 2 2 4 6 6 6 1 Hyaluronan mediated motility receptor C-terminal DUF4407 PF14362.6 ETS61687.1 - 0.00042 19.8 20.1 0.00042 19.8 20.1 5.7 2 1 4 6 6 6 1 Domain of unknown function (DUF4407) RACo_C_ter PF14574.6 ETS61687.1 - 0.072 12.1 0.5 0.16 11.0 0.5 1.5 1 0 0 1 1 1 0 C-terminal domain of RACo the ASKHA domain Baculo_PEP_C PF04513.12 ETS61687.1 - 1 9.4 31.8 0.12 12.4 2.4 4.9 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4358 PF14270.6 ETS61687.1 - 2.4 8.5 6.7 3.1 8.2 0.6 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) Vps53_N PF04100.12 ETS61688.1 - 1.2e-93 314.1 0.2 2.2e-93 313.3 0.2 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal Vps54_N PF10475.9 ETS61688.1 - 0.001 18.4 6.0 0.0019 17.6 6.0 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex NBD94 PF16830.5 ETS61688.1 - 0.046 14.1 0.5 0.11 12.9 0.5 1.6 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH Zw10 PF06248.13 ETS61688.1 - 0.071 11.7 4.2 0.23 10.0 4.2 1.9 1 1 0 1 1 1 0 Centromere/kinetochore Zw10 DUF5394 PF17372.2 ETS61688.1 - 0.082 12.5 2.9 0.15 11.6 2.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5394) MnmE_helical PF12631.7 ETS61688.1 - 0.096 12.8 3.8 0.69 10.1 4.2 2.0 2 0 0 2 2 2 0 MnmE helical domain Fib_alpha PF08702.10 ETS61688.1 - 1.3 9.2 8.5 1.5 9.0 6.8 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Baculo_PEP_C PF04513.12 ETS61688.1 - 6 6.9 8.7 8.3 6.4 6.1 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DEAD PF00270.29 ETS61689.1 - 7.9e-41 139.7 0.0 1.6e-40 138.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS61689.1 - 6.6e-25 87.6 0.0 1.9e-23 82.9 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 ETS61689.1 - 2.1e-21 75.9 0.7 2.1e-21 75.9 0.7 3.6 3 0 0 3 3 3 1 DBP10CT (NUC160) domain ResIII PF04851.15 ETS61689.1 - 1.1e-05 25.5 0.0 3.4e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC4 PF02732.15 ETS61690.1 - 1.7e-16 60.8 0.0 3e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain Phage_holin_1 PF04531.13 ETS61691.1 - 0.69 10.5 4.1 3.4 8.3 0.1 2.9 1 1 2 4 4 4 0 Bacteriophage holin DUF1774 PF08611.10 ETS61691.1 - 6.1 7.2 11.1 0.27 11.6 1.7 2.9 3 1 0 3 3 3 0 Fungal protein of unknown function (DUF1774) DUF1218 PF06749.12 ETS61691.1 - 9.6 6.8 12.9 2.5 8.7 1.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1218) Ribonuclease PF00545.20 ETS61692.1 - 2.7e-09 37.7 0.0 4.1e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 ribonuclease Oxysterol_BP PF01237.18 ETS61693.1 - 2.8e-89 299.5 0.1 7e-89 298.3 0.0 1.6 2 0 0 2 2 2 1 Oxysterol-binding protein Put_Phosphatase PF06888.12 ETS61693.1 - 6.8e-52 176.2 0.0 1.3e-51 175.3 0.0 1.4 1 0 0 1 1 1 1 Putative Phosphatase Ank_3 PF13606.6 ETS61693.1 - 4e-17 60.5 0.4 7.3e-05 22.9 0.0 4.2 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ETS61693.1 - 3.8e-15 56.2 1.1 1.3e-11 44.9 0.2 2.9 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETS61693.1 - 1.1e-12 47.8 0.2 0.0015 18.9 0.1 4.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ETS61693.1 - 5.8e-11 42.4 3.0 0.00029 21.1 0.2 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) PH PF00169.29 ETS61693.1 - 2.6e-10 40.8 0.1 5.7e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 PH domain Ank_4 PF13637.6 ETS61693.1 - 3e-09 37.2 1.1 2e-05 25.1 0.2 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) HAD PF12710.7 ETS61693.1 - 6.1e-09 36.5 0.0 6.1e-09 36.5 0.0 2.5 3 0 0 3 3 2 1 haloacid dehalogenase-like hydrolase PH_11 PF15413.6 ETS61693.1 - 5.9e-07 29.9 1.1 3.5e-06 27.4 0.2 2.9 3 1 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.6 ETS61693.1 - 2.6e-06 27.6 0.1 8e-06 26.1 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain LapD_MoxY_N PF16448.5 ETS61693.1 - 0.057 13.3 1.3 4.2 7.3 0.0 2.5 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain HAD_2 PF13419.6 ETS61693.1 - 0.32 11.1 2.1 0.8 9.8 0.7 2.4 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Asp PF00026.23 ETS61694.1 - 4.4e-36 124.9 0.0 2.2e-20 73.3 0.2 3.0 2 1 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS61694.1 - 2.4e-12 47.5 0.0 4e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal RhoGEF PF00621.20 ETS61696.1 - 3.9e-16 59.8 0.0 6.9e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain CBFD_NFYB_HMF PF00808.23 ETS61697.1 - 5.6e-14 52.2 0.2 8.6e-14 51.6 0.2 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ETS61697.1 - 1.7e-05 25.2 0.2 1.7e-05 25.2 0.2 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-W PF15510.6 ETS61697.1 - 0.015 15.5 0.1 0.021 15.1 0.1 1.2 1 0 0 1 1 1 0 CENP-W protein Trypan_PARP PF05887.11 ETS61697.1 - 0.16 11.9 9.1 0.27 11.2 9.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NOA36 PF06524.12 ETS61697.1 - 9.1 5.5 13.7 12 5.1 13.7 1.3 1 0 0 1 1 1 0 NOA36 protein Mlh1_C PF16413.5 ETS61698.1 - 1.9e-77 260.3 0.0 2.9e-77 259.7 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 ETS61698.1 - 4.1e-31 107.1 0.0 7.1e-31 106.4 0.0 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ETS61698.1 - 7.5e-11 42.0 0.0 2.1e-10 40.5 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ETS61698.1 - 1.5e-07 31.9 0.0 2.7e-06 27.9 0.0 2.5 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Folliculin PF11704.8 ETS61698.1 - 0.13 12.1 0.1 0.36 10.7 0.1 1.7 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport ALG11_N PF15924.5 ETS61699.1 - 3.9e-81 272.1 0.0 6e-81 271.5 0.0 1.3 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus EBP PF05241.12 ETS61699.1 - 1e-58 197.8 13.3 2.3e-58 196.6 13.3 1.6 1 0 0 1 1 1 1 Emopamil binding protein Glycos_transf_1 PF00534.20 ETS61699.1 - 4.1e-16 59.0 0.0 6.6e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ETS61699.1 - 4.6e-09 36.5 1.1 1.1e-08 35.3 1.1 1.7 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 ETS61699.1 - 6.8e-06 26.6 0.0 2.1e-05 25.0 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferases group 1 7tm_1 PF00001.21 ETS61699.1 - 0.04 13.2 0.0 0.07 12.4 0.0 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF5472 PF17566.2 ETS61699.1 - 0.11 12.5 0.4 2 8.4 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5472) HemY_N PF07219.13 ETS61699.1 - 0.18 12.0 6.5 1.2 9.4 1.0 3.6 2 0 0 2 2 2 0 HemY protein N-terminus Glyco_trans_4_4 PF13579.6 ETS61699.1 - 1.3 9.5 11.6 0.27 11.7 5.8 2.9 2 1 1 3 3 3 0 Glycosyl transferase 4-like domain B12D PF06522.11 ETS61701.1 - 1e-05 25.2 0.0 2.2e-05 24.2 0.0 1.6 1 1 1 2 2 2 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Ras PF00071.22 ETS61702.1 - 3.5e-53 179.5 0.0 5.2e-53 179.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61702.1 - 1.3e-29 102.8 0.0 2.1e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61702.1 - 4e-10 39.4 0.0 8.1e-10 38.4 0.0 1.4 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS61702.1 - 5.7e-06 26.4 0.0 1.2e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS61702.1 - 0.0028 17.2 0.0 0.039 13.5 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETS61702.1 - 0.074 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETS61702.1 - 0.16 11.9 0.0 0.47 10.3 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase SWIRM PF04433.17 ETS61703.1 - 2.9e-10 40.3 0.0 6.6e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain SR-25 PF10500.9 ETS61703.1 - 0.018 14.7 3.7 0.035 13.7 3.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1180 PF06679.12 ETS61703.1 - 3.8 7.9 9.7 0.13 12.7 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DEAD PF00270.29 ETS61704.1 - 4.6e-47 160.0 0.0 7.6e-47 159.3 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS61704.1 - 4.8e-31 107.4 0.1 2e-30 105.4 0.0 2.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS61704.1 - 1.7e-05 24.9 0.0 3.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SAPS PF04499.15 ETS61704.1 - 0.075 11.8 5.4 0.12 11.2 5.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 ETS61704.1 - 0.11 10.6 11.2 0.18 10.0 11.2 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETS61704.1 - 0.32 9.2 8.4 0.55 8.5 8.4 1.3 1 0 0 1 1 1 0 CDC45-like protein SMYLE_N PF18615.1 ETS61704.1 - 3.3 7.2 5.0 5.6 6.4 5.0 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain ORC6 PF05460.13 ETS61704.1 - 4 6.6 9.7 6.1 6.0 9.7 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) zf-HIT PF04438.16 ETS61705.1 - 2e-08 33.9 9.5 3e-08 33.4 9.5 1.3 1 0 0 1 1 1 1 HIT zinc finger Pkinase PF00069.25 ETS61706.1 - 2.6e-39 135.2 0.0 2.4e-27 96.0 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61706.1 - 5.9e-24 84.7 0.0 8.5e-24 84.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS61706.1 - 4.4e-07 29.0 0.0 7.2e-07 28.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF3844 PF12955.7 ETS61707.1 - 2.3e-29 101.6 1.5 3.7e-29 100.9 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) ERO1 PF04137.15 ETS61708.1 - 7.2e-129 430.0 0.0 8.9e-129 429.7 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) CDP-OH_P_transf PF01066.21 ETS61709.1 - 2.2e-16 60.4 2.0 5.3e-15 55.9 0.8 2.5 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ExoD PF06055.12 ETS61709.1 - 0.026 13.9 2.7 0.036 13.4 0.2 2.3 1 1 1 2 2 2 0 Exopolysaccharide synthesis, ExoD PPTA PF01239.22 ETS61710.1 - 2e-38 129.0 21.6 7.7e-09 35.0 3.0 5.5 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat IPPT PF01715.17 ETS61710.1 - 0.1 12.4 0.6 0.49 10.2 0.1 2.3 2 0 0 2 2 2 0 IPP transferase YfaZ PF07437.11 ETS61711.1 - 0.14 11.7 0.0 0.29 10.8 0.0 1.5 2 0 0 2 2 2 0 YfaZ precursor Cytochrom_c3_2 PF14537.6 ETS61711.1 - 8.7 6.9 18.1 7.5 7.1 4.3 2.3 2 0 0 2 2 2 0 Cytochrome c3 Glyco_hydro_59 PF02057.15 ETS61712.1 - 2.1e-08 33.7 1.0 5.7e-08 32.3 0.7 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 59 Glyco_hydro_30 PF02055.16 ETS61712.1 - 3.1e-08 33.0 0.6 6.9e-08 31.8 0.6 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain DUF2487 PF10673.9 ETS61712.1 - 0.032 14.3 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) Muskelin_N PF06588.11 ETS61714.1 - 1e-51 175.7 0.3 1.4e-19 70.8 0.0 3.5 3 1 0 3 3 3 3 Muskelin N-terminus Kelch_3 PF13415.6 ETS61714.1 - 2.7e-17 62.6 8.4 1.6e-08 34.6 0.0 6.2 7 0 0 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ETS61714.1 - 7.5e-16 57.7 2.3 0.0026 17.7 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 ETS61714.1 - 4.5e-14 52.2 7.7 5.2e-06 26.4 0.2 6.2 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ETS61714.1 - 1.5e-13 50.5 4.1 0.003 17.8 0.1 6.6 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 ETS61714.1 - 3e-10 39.5 3.1 0.00014 21.3 0.1 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETS61714.1 - 0.013 15.4 11.4 0.047 13.7 0.3 5.2 6 0 0 6 6 6 0 Kelch motif Tho1_MOS11_C PF18592.1 ETS61715.1 - 4.9e-12 45.5 3.0 4.9e-12 45.5 3.0 3.4 2 1 1 3 3 3 2 Tho1/MOS11 C-terminal domain SAP PF02037.27 ETS61715.1 - 3.1e-11 42.7 0.2 7.8e-11 41.5 0.2 1.7 1 0 0 1 1 1 1 SAP domain Ig_mannosidase PF17753.1 ETS61718.1 - 8.1e-10 38.3 0.0 1.8e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2 PF00703.21 ETS61718.1 - 0.0047 17.6 0.0 0.0097 16.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 2_5_RNA_ligase2 PF13563.6 ETS61718.1 - 0.0089 15.9 3.1 0.56 10.1 2.5 2.6 2 0 0 2 2 2 1 2'-5' RNA ligase superfamily FAD_binding_3 PF01494.19 ETS61719.1 - 2.8e-23 82.7 0.0 8e-23 81.2 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS61719.1 - 2.1e-05 23.9 0.0 0.0015 17.8 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETS61719.1 - 5.2e-05 22.3 0.8 0.0022 16.9 0.1 2.1 1 1 1 2 2 2 1 Tryptophan halogenase NAD_binding_8 PF13450.6 ETS61719.1 - 0.00013 22.1 1.3 0.00041 20.5 1.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ETS61719.1 - 0.00042 20.3 0.0 0.00086 19.3 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 ETS61719.1 - 0.00044 20.7 0.3 0.0012 19.4 0.3 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS61719.1 - 0.003 16.7 2.2 0.0049 16.0 2.2 1.3 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 ETS61719.1 - 0.0039 16.5 0.0 0.62 9.3 0.0 3.2 3 1 0 3 3 3 1 Flavin containing amine oxidoreductase DAO PF01266.24 ETS61719.1 - 0.0047 16.6 3.2 0.017 14.8 2.9 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ETS61719.1 - 0.061 12.0 0.8 0.093 11.4 0.8 1.2 1 0 0 1 1 1 0 HI0933-like protein SE PF08491.10 ETS61719.1 - 0.086 11.9 0.0 3.7 6.5 0.0 2.3 2 1 0 2 2 2 0 Squalene epoxidase GIDA PF01134.22 ETS61719.1 - 0.17 10.9 1.2 0.26 10.3 1.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A PRA1 PF03208.19 ETS61720.1 - 1.2e-32 112.5 1.3 1.5e-32 112.2 1.3 1.0 1 0 0 1 1 1 1 PRA1 family protein Tetraspanin PF00335.20 ETS61720.1 - 0.6 9.8 5.1 0.9 9.2 5.1 1.3 1 0 0 1 1 1 0 Tetraspanin family tRNA-synt_2c PF01411.19 ETS61722.1 - 1.6e-213 710.2 0.0 2.2e-213 709.8 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ETS61722.1 - 1.1e-17 63.8 0.3 3.1e-17 62.4 0.3 1.8 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ETS61722.1 - 3.8e-11 43.6 11.4 1.3e-10 41.9 11.4 2.0 1 1 0 1 1 1 1 DHHA1 domain Tom37 PF10568.9 ETS61722.1 - 0.21 11.9 0.0 0.71 10.2 0.0 1.9 2 0 0 2 2 2 0 Outer mitochondrial membrane transport complex protein RMI1_N PF08585.12 ETS61723.1 - 2.1e-46 158.4 0.0 3.5e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 RecQ mediated genome instability protein Ribosomal_S8e PF01201.22 ETS61724.1 - 6.8e-47 159.1 2.1 1.5e-46 158.0 2.1 1.5 1 1 0 1 1 1 1 Ribosomal protein S8e Red1 PF07964.11 ETS61724.1 - 0.63 8.2 6.0 0.71 8.0 6.0 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Macoilin PF09726.9 ETS61724.1 - 6.9 5.1 10.5 9.1 4.7 10.5 1.0 1 0 0 1 1 1 0 Macoilin family FlbD PF06289.11 ETS61725.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins Na_Ca_ex PF01699.24 ETS61726.1 - 2.9e-30 105.2 25.1 3.9e-16 59.4 4.0 3.0 2 1 0 2 2 2 2 Sodium/calcium exchanger protein Velvet PF11754.8 ETS61726.1 - 0.0034 17.3 1.5 0.0042 17.1 0.4 1.6 2 0 0 2 2 2 1 Velvet factor MscL PF01741.18 ETS61726.1 - 0.086 13.1 0.3 0.19 12.1 0.3 1.5 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL BUD22 PF09073.10 ETS61726.1 - 0.14 11.5 2.3 0.22 10.9 2.3 1.2 1 0 0 1 1 1 0 BUD22 SIR2 PF02146.17 ETS61727.1 - 1e-30 107.0 0.0 1.3e-29 103.4 0.0 2.0 1 1 0 1 1 1 1 Sir2 family SF3b1 PF08920.10 ETS61728.1 - 5.3e-19 68.9 4.1 5.3e-19 68.9 4.1 3.3 2 1 1 3 3 3 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 ETS61728.1 - 4e-10 39.9 15.8 0.0013 19.1 0.1 8.6 6 2 4 10 10 10 3 HEAT repeats HEAT_EZ PF13513.6 ETS61728.1 - 1.7e-09 38.0 6.8 0.027 15.0 0.0 7.2 7 1 1 8 8 7 2 HEAT-like repeat Adaptin_N PF01602.20 ETS61728.1 - 2.5e-07 29.6 1.6 0.13 10.8 0.1 4.0 2 2 1 4 4 4 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ETS61728.1 - 2.3e-05 24.9 0.4 2.4 8.8 0.0 5.0 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 ETS61728.1 - 2.6e-05 24.0 1.1 0.58 9.8 0.0 4.7 4 1 1 5 5 5 2 NUC173 domain HEAT PF02985.22 ETS61728.1 - 7.7e-05 22.6 12.0 1.2 9.5 0.1 8.5 11 0 0 11 11 10 1 HEAT repeat CLASP_N PF12348.8 ETS61728.1 - 9.6e-05 22.0 0.6 0.095 12.3 0.0 3.4 3 0 0 3 3 3 1 CLASP N terminal DUF3385 PF11865.8 ETS61728.1 - 0.0019 18.1 6.0 0.46 10.4 0.1 5.1 6 2 0 6 6 5 1 Domain of unknown function (DUF3385) Cnd1 PF12717.7 ETS61728.1 - 0.0023 18.0 9.3 6.3 6.8 0.0 6.3 7 1 0 7 7 7 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 ETS61728.1 - 0.0031 16.7 0.1 5.1 6.1 0.0 4.0 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal UME PF08064.13 ETS61728.1 - 0.0054 16.6 0.1 1.3 8.9 0.0 4.3 5 1 1 6 6 5 1 UME (NUC010) domain Dopey_N PF04118.14 ETS61728.1 - 0.0062 15.7 2.0 0.079 12.1 0.0 3.1 3 0 0 3 3 3 1 Dopey, N-terminal LIDHydrolase PF10230.9 ETS61728.1 - 0.022 14.3 0.3 0.23 11.0 0.1 2.3 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase N1221 PF07923.13 ETS61728.1 - 0.073 12.2 1.7 5.3 6.1 0.0 3.3 3 0 0 3 3 3 0 N1221-like protein DUF1428 PF07237.11 ETS61728.1 - 0.11 12.8 0.1 0.43 10.9 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1428) Hva1_TUDOR PF11160.8 ETS61729.1 - 1.3e-17 63.7 3.5 1.7e-17 63.3 3.5 1.2 1 0 0 1 1 1 1 Hypervirulence associated proteins TUDOR domain ProQ_C PF17516.2 ETS61729.1 - 0.037 13.5 0.0 0.14 11.6 0.0 1.9 1 1 1 2 2 2 0 ProQ C-terminal domain GMC_oxred_C PF05199.13 ETS61730.1 - 1.4e-13 51.6 0.1 3.4e-13 50.3 0.1 1.7 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_N PF00732.19 ETS61730.1 - 3e-09 36.7 0.0 5.6e-08 32.5 0.0 2.3 1 1 0 1 1 1 1 GMC oxidoreductase MAPEG PF01124.18 ETS61730.1 - 2.1e-08 34.1 1.7 2.3e-08 34.0 0.3 1.7 2 0 0 2 2 2 1 MAPEG family Pyr_redox_2 PF07992.14 ETS61730.1 - 0.0012 18.2 0.1 0.36 10.0 0.0 3.1 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS61730.1 - 0.0042 16.4 0.0 0.88 8.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS61730.1 - 0.0088 16.3 0.0 0.027 14.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETS61730.1 - 0.031 13.8 1.8 0.083 12.4 0.4 2.5 2 1 0 2 2 2 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETS61730.1 - 0.043 12.9 0.1 0.14 11.2 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain Glyco_trans_2_3 PF13632.6 ETS61731.1 - 5.8e-46 156.9 2.5 5.8e-46 156.9 2.5 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ETS61731.1 - 6.6e-05 22.8 0.0 0.0029 17.5 0.0 2.7 2 1 0 2 2 2 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ETS61731.1 - 0.00015 21.7 0.0 0.00037 20.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_hydro_16 PF00722.21 ETS61732.1 - 2.6e-17 62.8 0.4 4.9e-17 62.0 0.4 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_hydro_16 PF00722.21 ETS61733.1 - 3.2e-19 69.1 0.7 5.6e-19 68.3 0.7 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_trans_2_3 PF13632.6 ETS61734.1 - 2.8e-43 148.1 12.2 2.8e-43 148.1 12.2 2.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ETS61734.1 - 0.035 13.9 0.0 0.08 12.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ETS61734.1 - 0.073 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 21 Cutinase PF01083.22 ETS61736.1 - 2.4e-14 53.7 0.0 5.5e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 Cutinase PAP2 PF01569.21 ETS61737.1 - 1.2e-18 67.1 3.3 1.2e-18 67.1 3.3 2.6 2 1 1 3 3 3 1 PAP2 superfamily PAP2_3 PF14378.6 ETS61737.1 - 0.0017 18.1 6.7 0.0017 18.1 6.7 2.2 2 0 0 2 2 2 1 PAP2 superfamily Carm_PH PF17888.1 ETS61737.1 - 0.067 13.6 0.1 0.18 12.2 0.1 1.7 1 0 0 1 1 1 0 Carmil pleckstrin homology domain AAA PF00004.29 ETS61738.1 - 2.2e-85 283.7 0.0 3.7e-42 143.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS61738.1 - 2.8e-30 103.8 0.9 1e-14 54.0 0.2 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_5 PF07728.14 ETS61738.1 - 7e-14 52.0 0.0 4e-07 30.1 0.0 3.9 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETS61738.1 - 2.1e-12 47.7 1.1 8.9e-06 26.2 0.1 3.8 2 2 0 2 2 2 2 AAA ATPase domain RuvB_N PF05496.12 ETS61738.1 - 8.8e-12 45.0 0.0 5.7e-05 22.9 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ETS61738.1 - 8.4e-09 35.1 0.0 0.0025 17.1 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 ETS61738.1 - 3.3e-08 33.8 0.0 0.00053 20.2 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ETS61738.1 - 3.5e-07 30.6 1.0 0.015 15.6 0.2 4.2 2 2 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ETS61738.1 - 4.6e-06 26.9 0.0 0.19 11.9 0.0 3.1 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ETS61738.1 - 1.1e-05 26.0 0.1 0.011 16.2 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 ETS61738.1 - 1.4e-05 25.4 0.0 0.023 14.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 ETS61738.1 - 1.7e-05 24.8 0.0 0.028 14.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 ETS61738.1 - 2e-05 24.4 0.0 0.036 13.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein Rad17 PF03215.15 ETS61738.1 - 2.2e-05 24.5 0.0 0.039 13.9 0.0 3.2 2 1 1 3 3 3 1 Rad17 P-loop domain RNA_helicase PF00910.22 ETS61738.1 - 2.2e-05 24.8 0.0 0.11 12.9 0.0 2.5 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 ETS61738.1 - 4.9e-05 22.8 0.5 0.27 10.6 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ETS61738.1 - 0.00019 21.4 0.0 0.14 12.1 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ETS61738.1 - 0.00024 20.7 0.0 0.087 12.3 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 ETS61738.1 - 0.00055 20.1 0.0 0.47 10.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 ETS61738.1 - 0.00056 19.5 2.3 0.26 10.8 0.2 3.4 2 2 2 4 4 4 1 AAA domain AAA_3 PF07726.11 ETS61738.1 - 0.0015 18.4 0.0 2.3 8.1 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ETS61738.1 - 0.0015 17.8 0.1 0.059 12.6 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 ETS61738.1 - 0.0018 18.0 0.0 0.046 13.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 ETS61738.1 - 0.0033 16.6 0.0 0.29 10.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DUF815 PF05673.13 ETS61738.1 - 0.0034 16.6 0.0 0.041 13.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 ETS61738.1 - 0.0038 17.0 0.0 2 8.1 0.0 3.4 3 1 0 3 3 2 1 Sigma-54 interaction domain ATPase_2 PF01637.18 ETS61738.1 - 0.0071 16.3 0.0 2.9 7.7 0.0 3.6 3 2 1 4 4 4 1 ATPase domain predominantly from Archaea AAA_11 PF13086.6 ETS61738.1 - 0.0076 16.1 0.0 0.69 9.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ETS61738.1 - 0.0092 15.9 0.1 0.43 10.5 0.0 3.0 2 1 0 2 2 2 1 NACHT domain ABC_tran PF00005.27 ETS61738.1 - 0.02 15.4 0.0 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 ABC transporter ATPase PF06745.13 ETS61738.1 - 0.031 13.6 0.0 3.5 6.9 0.0 2.6 2 0 0 2 2 2 0 KaiC PhoH PF02562.16 ETS61738.1 - 0.039 13.4 0.4 1.2 8.5 0.2 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 ETS61738.1 - 0.043 13.5 0.1 0.5 10.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETS61738.1 - 0.052 14.0 0.0 0.15 12.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain IPT PF01745.16 ETS61738.1 - 0.063 12.7 0.2 1.9 7.8 0.1 2.3 2 0 0 2 2 2 0 Isopentenyl transferase Adeno_IVa2 PF02456.15 ETS61738.1 - 0.14 10.9 0.1 1.8 7.3 0.0 2.4 3 0 0 3 3 3 0 Adenovirus IVa2 protein Cytidylate_kin PF02224.18 ETS61738.1 - 0.18 11.5 2.4 1.2 8.8 0.1 2.8 3 0 0 3 3 3 0 Cytidylate kinase GDI PF00996.18 ETS61739.1 - 2.2e-35 122.0 0.0 1.5e-20 73.2 0.0 3.1 3 0 0 3 3 3 3 GDP dissociation inhibitor Abhydrolase_3 PF07859.13 ETS61739.1 - 0.02 14.7 0.0 0.047 13.5 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Sas10_Utp3 PF04000.15 ETS61740.1 - 1.2e-12 48.3 0.5 3.6e-12 46.7 0.5 1.9 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Macoilin PF09726.9 ETS61740.1 - 0.018 13.7 4.0 0.11 11.0 0.1 2.3 1 1 1 2 2 2 0 Macoilin family Zn_clus PF00172.18 ETS61741.1 - 2.9e-05 24.1 9.2 6.6e-05 22.9 9.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SKN1 PF03935.15 ETS61742.1 - 1.6e-202 673.4 0.0 1.9e-202 673.1 0.0 1.1 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 ETS61742.1 - 0.024 14.1 0.1 0.17 11.4 0.0 2.3 2 0 0 2 2 2 0 Glycosyl hydrolases family 16 zf-C2H2 PF00096.26 ETS61743.1 - 2.4e-12 46.6 14.0 7.2e-06 26.2 0.3 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS61743.1 - 1.8e-07 31.4 10.2 0.0074 17.0 0.2 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETS61743.1 - 1.6e-06 27.9 0.5 0.00028 20.8 0.0 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETS61743.1 - 0.00011 22.5 11.8 0.074 13.5 0.8 4.3 4 0 0 4 4 4 2 Zinc-finger double domain zf_ZIC PF18366.1 ETS61743.1 - 0.13 12.4 0.0 4.4 7.5 0.0 2.6 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-ribbon_3 PF13248.6 ETS61743.1 - 0.16 11.5 1.0 2.5 7.6 0.0 2.6 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_jaz PF12171.8 ETS61743.1 - 0.18 12.1 3.4 0.57 10.5 0.1 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 ETS61743.1 - 0.34 11.3 4.1 6.7 7.1 4.7 2.5 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_4 PF13717.6 ETS61743.1 - 1 9.4 4.0 3.8 7.5 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 ETS61743.1 - 1.3 9.2 5.7 1.7 8.8 0.5 2.8 3 0 0 3 3 3 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ETS61743.1 - 8.7 6.4 9.6 10 6.2 1.4 2.8 2 1 0 2 2 2 0 Transposase zinc-ribbon domain LMP PF04778.12 ETS61744.1 - 0.11 12.4 0.5 0.21 11.5 0.5 1.4 1 0 0 1 1 1 0 LMP repeated region APG6_N PF17675.1 ETS61744.1 - 0.17 12.4 2.2 0.35 11.4 2.2 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 ETS61744.1 - 0.28 11.4 3.7 0.66 10.2 3.7 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain AT_hook PF02178.19 ETS61745.1 - 6.7e-08 31.5 80.8 0.05 13.5 1.8 8.2 8 0 0 8 8 8 7 AT hook motif SlyX PF04102.12 ETS61745.1 - 0.025 15.2 2.7 0.071 13.7 2.7 1.8 1 0 0 1 1 1 0 SlyX SKG6 PF08693.10 ETS61746.1 - 0.0057 16.0 0.7 0.018 14.5 0.7 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain EphA2_TM PF14575.6 ETS61746.1 - 0.029 15.2 0.0 0.11 13.4 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Herpes_gE PF02480.16 ETS61746.1 - 0.044 12.5 0.1 0.36 9.5 0.0 2.2 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E DAP10 PF07213.11 ETS61746.1 - 0.085 12.8 0.3 0.085 12.8 0.3 2.3 2 0 0 2 2 2 0 DAP10 membrane protein Syndecan PF01034.20 ETS61746.1 - 0.15 12.0 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 Syndecan domain TNFR_16_TM PF18422.1 ETS61746.1 - 0.57 10.2 1.4 1.3 9.1 1.4 1.5 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain Glycoamylase PF10091.9 ETS61746.1 - 0.65 9.5 4.4 1 8.9 1.7 2.1 2 0 0 2 2 2 0 Putative glucoamylase SARAF PF06682.12 ETS61746.1 - 0.67 9.6 19.7 0.025 14.2 4.7 2.4 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis ATP19 PF11022.8 ETS61746.1 - 3.2 8.2 0.0 3.2 8.2 0.0 4.5 7 0 0 7 7 7 0 ATP synthase subunit K Adeno_E3_CR2 PF02439.15 ETS61747.1 - 0.088 12.6 0.5 0.18 11.6 0.5 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 SKG6 PF08693.10 ETS61747.1 - 0.17 11.3 2.0 0.48 9.9 2.0 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain FAD_binding_1 PF00667.20 ETS61748.1 - 1.7e-54 184.7 0.0 2.9e-54 184.0 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ETS61748.1 - 6.3e-07 30.0 0.0 2.9e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ETS61748.1 - 0.069 13.5 0.0 0.85 10.0 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain DUF3729 PF12526.8 ETS61748.1 - 3.2 9.4 12.3 0.77 11.4 6.3 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3729) APG12 PF04110.13 ETS61749.1 - 4.2e-33 113.6 0.0 5.3e-33 113.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 ETS61749.1 - 0.00083 19.5 0.0 0.001 19.2 0.0 1.2 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Ufm1 PF03671.14 ETS61749.1 - 0.015 15.3 0.0 0.074 13.2 0.0 1.9 1 1 1 2 2 2 0 Ubiquitin fold modifier 1 protein Ribosomal_L30_N PF08079.12 ETS61750.1 - 6.5e-28 96.8 18.3 1.1e-27 96.1 18.3 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 ETS61750.1 - 5.6e-17 61.4 2.1 1.1e-16 60.4 2.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF3682 PF12446.8 ETS61750.1 - 0.067 13.7 1.1 0.11 12.9 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Alk_phosphatase PF00245.20 ETS61751.1 - 6.4e-74 249.4 0.0 6.6e-65 219.7 0.0 2.1 2 0 0 2 2 2 2 Alkaline phosphatase LRR_4 PF12799.7 ETS61752.1 - 0.027 14.9 0.3 16 6.0 0.0 3.0 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) Y_phosphatase2 PF03162.13 ETS61753.1 - 6e-49 165.8 0.0 1.1e-48 165.0 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Prefoldin PF02996.17 ETS61753.1 - 2.4e-29 101.7 0.2 3.6e-29 101.1 0.2 1.3 1 0 0 1 1 1 1 Prefoldin subunit Y_phosphatase3 PF13350.6 ETS61753.1 - 2.2e-07 31.1 0.0 8.5e-07 29.2 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family BCAS3 PF12490.8 ETS61753.1 - 0.028 13.9 0.1 0.063 12.8 0.1 1.6 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 AAA_23 PF13476.6 ETS61753.1 - 0.13 12.8 0.7 0.2 12.1 0.7 1.2 1 0 0 1 1 1 0 AAA domain Syntaxin-6_N PF09177.11 ETS61753.1 - 0.13 12.8 1.8 5.8 7.5 0.3 2.5 2 0 0 2 2 2 0 Syntaxin 6, N-terminal OHCU_decarbox PF09349.10 ETS61754.1 - 2e-25 90.1 0.0 6.1e-25 88.5 0.0 1.9 1 0 0 1 1 1 1 OHCU decarboxylase adh_short PF00106.25 ETS61755.1 - 8.7e-52 175.4 0.1 1.1e-51 175.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS61755.1 - 3.4e-34 118.4 0.1 4.4e-34 118.0 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS61755.1 - 2.7e-13 50.2 0.1 3.3e-13 49.9 0.1 1.1 1 0 0 1 1 1 1 KR domain GDP_Man_Dehyd PF16363.5 ETS61755.1 - 0.0002 20.9 0.0 0.00026 20.5 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETS61755.1 - 0.00085 18.9 0.1 0.0014 18.2 0.1 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 2-Hacid_dh_C PF02826.19 ETS61755.1 - 0.0013 18.2 0.0 0.0024 17.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ETS61755.1 - 0.0018 18.2 0.5 0.0031 17.4 0.5 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 ETS61755.1 - 0.002 17.4 0.1 0.0049 16.2 0.1 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ThiF PF00899.21 ETS61755.1 - 0.017 14.5 0.1 0.028 13.8 0.1 1.3 1 0 0 1 1 1 0 ThiF family Eno-Rase_NADH_b PF12242.8 ETS61755.1 - 0.041 13.7 0.1 0.076 12.8 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase ApbA PF02558.16 ETS61755.1 - 0.046 13.4 0.6 0.079 12.6 0.6 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Polysacc_synt_2 PF02719.15 ETS61755.1 - 0.054 12.6 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DASH_Dad3 PF08656.10 ETS61757.1 - 3.8e-19 68.5 0.9 6.5e-19 67.8 0.9 1.3 1 0 0 1 1 1 1 DASH complex subunit Dad3 Mce4_CUP1 PF11887.8 ETS61757.1 - 0.013 15.0 0.1 0.017 14.6 0.1 1.2 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative MetOD2 PF18548.1 ETS61757.1 - 0.017 15.2 0.8 6.5 6.9 0.0 2.5 1 1 2 3 3 3 0 Metanogen output domain 2 Abhydrolase_1 PF00561.20 ETS61758.1 - 2.3e-23 83.2 0.1 4.2e-21 75.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS61758.1 - 4.7e-12 47.0 8.4 6.1e-12 46.6 8.4 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS61758.1 - 1e-08 34.8 0.0 1.4e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 ETS61758.1 - 0.011 14.5 0.0 0.024 13.3 0.0 1.5 2 0 0 2 2 2 0 Ndr family DUF3530 PF12048.8 ETS61758.1 - 0.025 14.0 0.0 0.04 13.3 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) PAE PF03283.13 ETS61762.1 - 1.3e-15 57.4 0.8 2e-15 56.8 0.8 1.2 1 0 0 1 1 1 1 Pectinacetylesterase RNA_pol_I_A49 PF06870.12 ETS61763.1 - 9.3e-112 373.7 0.0 1.5e-111 373.0 0.0 1.3 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor DUF2201_N PF13203.6 ETS61763.1 - 0.38 10.3 8.3 4 7.0 0.0 2.3 2 0 0 2 2 2 0 Putative metallopeptidase domain TFIIE-A_C PF11521.8 ETS61763.1 - 0.66 10.3 5.4 1.9 8.8 1.9 2.5 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha TMEM247 PF15444.6 ETS61763.1 - 1.8 8.5 0.0 1.8 8.5 0.0 2.5 3 0 0 3 3 3 0 Transmembrane protein 247 PHP PF02811.19 ETS61764.1 - 1.6e-07 31.8 0.0 6.3e-07 29.8 0.0 1.8 1 1 0 1 1 1 1 PHP domain FA_hydroxylase PF04116.13 ETS61765.1 - 9.3e-24 84.3 20.1 1e-23 84.1 17.6 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Mtc PF03820.17 ETS61766.1 - 6.6e-115 383.4 0.3 7.5e-115 383.2 0.3 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier WD40 PF00400.32 ETS61767.1 - 2.2e-22 78.9 12.7 0.0029 18.4 0.0 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS61767.1 - 1.1e-05 25.6 0.0 0.36 11.1 0.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2415 PF10313.9 ETS61767.1 - 0.0014 18.5 0.0 0.012 15.5 0.0 2.6 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) DAZAP2 PF11029.8 ETS61767.1 - 0.0021 19.0 2.5 0.0055 17.6 2.5 1.7 1 0 0 1 1 1 1 DAZ associated protein 2 (DAZAP2) Ge1_WD40 PF16529.5 ETS61767.1 - 0.0029 16.6 0.0 0.27 10.2 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein gag_pre-integrs PF13976.6 ETS61767.1 - 0.14 12.0 1.1 7.3 6.5 0.5 2.9 3 0 0 3 3 3 0 GAG-pre-integrase domain p450 PF00067.22 ETS61768.1 - 2.1e-26 92.7 0.1 6.4e-26 91.1 0.1 1.6 1 1 0 1 1 1 1 Cytochrome P450 ENTH PF01417.20 ETS61769.1 - 2.6e-50 169.7 0.2 5.1e-50 168.7 0.2 1.5 1 0 0 1 1 1 1 ENTH domain UIM PF02809.20 ETS61769.1 - 1e-05 25.1 7.3 0.0041 17.0 1.2 3.2 2 0 0 2 2 2 2 Ubiquitin interaction motif ANTH PF07651.16 ETS61769.1 - 0.00027 20.0 1.0 0.0005 19.1 1.0 1.5 1 0 0 1 1 1 1 ANTH domain Septin PF00735.18 ETS61770.1 - 6.1e-113 376.8 0.2 8.1e-113 376.4 0.2 1.1 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ETS61770.1 - 3.1e-09 36.9 0.0 7.6e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS61770.1 - 9.7e-08 32.1 1.7 6.2e-07 29.5 0.2 2.6 3 0 0 3 3 2 1 RsgA GTPase GTP_EFTU PF00009.27 ETS61770.1 - 9.1e-07 28.6 5.2 3.1e-05 23.6 0.3 3.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.22 ETS61770.1 - 4.1e-05 23.2 0.4 0.00015 21.4 0.4 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETS61770.1 - 4.2e-05 23.8 0.2 0.0001 22.5 0.2 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ETS61770.1 - 0.00015 22.2 0.3 0.00076 19.9 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain AIG1 PF04548.16 ETS61770.1 - 0.00042 19.7 0.1 0.0009 18.6 0.1 1.5 1 0 0 1 1 1 1 AIG1 family AAA_22 PF13401.6 ETS61770.1 - 0.00089 19.5 1.5 0.0019 18.5 0.1 2.2 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETS61770.1 - 0.0022 18.5 0.2 0.0062 17.1 0.0 1.8 2 0 0 2 2 2 1 ABC transporter PduV-EutP PF10662.9 ETS61770.1 - 0.0059 16.3 1.6 0.22 11.3 0.1 2.7 2 1 1 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 ETS61770.1 - 0.01 15.6 0.7 0.021 14.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 ETS61770.1 - 0.014 14.7 1.1 0.026 13.9 0.0 2.0 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region NACHT PF05729.12 ETS61770.1 - 0.017 15.1 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Mg_chelatase PF01078.21 ETS61770.1 - 0.021 14.2 0.0 0.043 13.2 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 ETS61770.1 - 0.023 14.2 0.1 0.044 13.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NB-ARC PF00931.22 ETS61770.1 - 0.024 13.8 0.0 0.041 13.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_29 PF13555.6 ETS61770.1 - 0.026 14.2 0.1 0.05 13.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 ETS61770.1 - 0.029 13.9 0.2 0.087 12.3 0.2 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 ETS61770.1 - 0.047 13.5 1.4 2.6 7.8 0.1 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Sigma54_activat PF00158.26 ETS61770.1 - 0.048 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain CLP1_P PF16575.5 ETS61770.1 - 0.065 13.0 0.1 2.2 8.1 0.0 2.4 1 1 1 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop RNA_helicase PF00910.22 ETS61770.1 - 0.076 13.4 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.6 ETS61770.1 - 0.089 13.3 4.7 0.16 12.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ETS61770.1 - 0.09 12.4 0.3 0.47 10.0 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.12 ETS61770.1 - 0.11 12.0 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_14 PF13173.6 ETS61770.1 - 0.12 12.4 0.4 0.26 11.3 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA PF00004.29 ETS61770.1 - 0.44 11.0 3.9 0.53 10.7 0.2 2.7 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 ETS61770.1 - 0.45 10.6 7.2 2.4 8.2 0.3 2.9 2 1 1 3 3 3 0 Dynamin family Cep57_CLD_2 PF14197.6 ETS61770.1 - 0.67 10.1 6.6 0.32 11.1 3.4 2.1 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 zf-CSL PF05207.13 ETS61771.1 - 4.9e-23 80.6 1.1 7e-23 80.1 1.1 1.2 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 ETS61771.1 - 0.00037 20.5 0.5 0.00067 19.7 0.5 1.4 1 0 0 1 1 1 1 Zinc ribbon domain zf-RING_4 PF14570.6 ETS61771.1 - 0.0026 17.5 0.8 0.0045 16.7 0.8 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zinc_ribbon_4 PF13717.6 ETS61771.1 - 0.013 15.4 1.1 0.025 14.5 1.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-RING_7 PF02591.15 ETS61771.1 - 0.036 14.2 0.2 0.09 13.0 0.1 1.7 2 0 0 2 2 2 0 C4-type zinc ribbon domain Ras PF00071.22 ETS61772.1 - 1.2e-54 184.3 0.1 1.4e-54 184.1 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS61772.1 - 7e-31 106.9 0.0 9e-31 106.6 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS61772.1 - 3.2e-16 59.3 0.0 4.7e-16 58.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS61772.1 - 2e-05 24.7 0.1 2.9e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETS61772.1 - 0.0029 17.0 0.0 0.0036 16.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ETS61772.1 - 0.0087 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ETS61772.1 - 0.0093 15.5 0.1 0.025 14.1 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ETS61772.1 - 0.039 13.7 0.2 0.14 11.9 0.0 1.8 1 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ETS61772.1 - 0.066 13.1 0.0 1.3 9.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase TniB PF05621.11 ETS61772.1 - 0.25 10.8 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Pil1 PF13805.6 ETS61773.1 - 2.3e-18 66.7 1.3 4.6e-18 65.6 1.3 1.4 1 0 0 1 1 1 1 Eisosome component PIL1 Glyco_hydro_32N PF00251.20 ETS61774.1 - 1.2e-46 159.7 0.0 1.7e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 ETS61774.1 - 2e-19 70.1 0.0 3.2e-19 69.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal DUF4975 PF16346.5 ETS61774.1 - 0.0034 17.5 0.0 0.0056 16.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4975) BNR PF02012.20 ETS61774.1 - 0.042 13.8 0.3 1.7 9.0 0.1 3.0 2 0 0 2 2 2 0 BNR/Asp-box repeat TMEM119 PF15724.5 ETS61774.1 - 0.077 13.1 2.6 0.14 12.2 2.6 1.3 1 0 0 1 1 1 0 TMEM119 family Polysacc_deac_1 PF01522.21 ETS61777.1 - 1.8e-05 24.6 0.0 3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Claudin_3 PF06653.11 ETS61777.1 - 3.6 7.5 14.5 0.74 9.7 2.4 2.5 2 1 0 2 2 2 0 Tight junction protein, Claudin-like EPSP_synthase PF00275.20 ETS61778.1 - 8.3e-117 390.4 0.1 1.2e-116 389.8 0.1 1.3 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 ETS61778.1 - 9.1e-98 326.6 0.0 3.4e-97 324.7 0.0 2.0 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 ETS61778.1 - 4.6e-52 177.5 0.0 1e-51 176.4 0.0 1.6 1 0 0 1 1 1 1 Type I 3-dehydroquinase Shikimate_dh_N PF08501.11 ETS61778.1 - 4.6e-26 90.9 0.0 1.6e-25 89.2 0.0 2.0 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SKI PF01202.22 ETS61778.1 - 1.1e-24 87.3 0.0 1.2e-23 84.0 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase SDH_C PF18317.1 ETS61778.1 - 3.5e-08 33.1 0.0 7.6e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 ETS61778.1 - 2.1e-05 24.6 0.0 5.1e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.6 ETS61778.1 - 4.1e-05 23.4 0.6 0.00024 20.9 0.2 2.3 2 1 0 2 2 2 1 Iron-containing alcohol dehydrogenase OCD_Mu_crystall PF02423.15 ETS61778.1 - 0.0072 15.3 0.5 0.1 11.5 0.1 2.3 2 0 0 2 2 2 1 Ornithine cyclodeaminase/mu-crystallin family Fe-ADH PF00465.19 ETS61778.1 - 0.019 13.8 2.1 0.26 10.1 0.1 3.3 4 0 0 4 4 4 0 Iron-containing alcohol dehydrogenase SURF6 PF04935.12 ETS61779.1 - 1.3e-46 159.0 37.3 1.3e-46 159.0 37.3 3.3 2 1 1 3 3 3 1 Surfeit locus protein 6 RRP14 PF15459.6 ETS61779.1 - 4.9e-17 62.3 5.7 4.9e-17 62.3 5.7 6.0 6 1 0 6 6 6 1 60S ribosome biogenesis protein Rrp14 PAP2 PF01569.21 ETS61780.1 - 1.4e-19 70.2 3.3 4.4e-19 68.6 3.3 1.9 1 0 0 1 1 1 1 PAP2 superfamily SOCS_box PF07525.16 ETS61781.1 - 0.13 12.7 1.1 0.4 11.1 0.2 2.0 2 0 0 2 2 2 0 SOCS box TRAM_LAG1_CLN8 PF03798.16 ETS61782.1 - 3.4e-44 150.9 21.6 3.4e-44 150.9 21.6 2.6 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 ETS61782.1 - 7.6e-08 31.9 0.0 7.6e-08 31.9 0.0 3.2 3 1 0 3 3 3 1 TRAM1-like protein DUF4834 PF16118.5 ETS61782.1 - 0.2 12.6 0.0 0.68 10.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EF-1_beta_acid PF10587.9 ETS61782.1 - 1.8 9.1 5.6 4.1 7.9 5.6 1.6 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Fungal_trans PF04082.18 ETS61784.1 - 8.3e-30 103.7 0.0 1.5e-29 102.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61784.1 - 7.2e-10 38.8 8.8 1.2e-09 38.1 8.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GMC_oxred_N PF00732.19 ETS61786.1 - 4e-56 190.6 0.0 5.2e-56 190.2 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS61786.1 - 1.3e-35 123.0 0.1 2.8e-35 122.0 0.1 1.6 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ETS61786.1 - 5.3e-05 22.5 0.6 0.094 11.8 0.5 2.3 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 ETS61786.1 - 0.0015 17.8 0.2 0.0029 16.9 0.2 1.4 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.12 ETS61786.1 - 0.0015 17.6 0.1 0.0025 16.9 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 ETS61786.1 - 0.0046 16.6 0.1 0.018 14.7 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS61786.1 - 0.011 16.0 0.2 0.039 14.2 0.2 2.0 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETS61786.1 - 0.035 13.3 0.3 0.58 9.3 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS61786.1 - 0.037 12.7 0.3 4.9 5.7 0.2 2.2 2 0 0 2 2 2 0 HI0933-like protein Metallophos PF00149.28 ETS61787.1 - 4.5e-14 53.4 0.0 1.7e-13 51.5 0.0 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETS61787.1 - 0.0005 20.3 0.0 0.16 12.2 0.0 2.3 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Phos_pyr_kin PF08543.12 ETS61788.1 - 6.5e-73 245.1 0.1 3.2e-54 183.9 0.0 3.0 2 1 0 2 2 2 2 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 ETS61788.1 - 1.3e-33 116.6 0.1 1.3e-33 116.6 0.1 1.8 3 0 0 3 3 3 1 TENA/THI-4/PQQC family MFS_1 PF07690.16 ETS61788.1 - 4.2e-26 91.7 26.7 8e-26 90.8 22.2 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61788.1 - 7.8e-08 31.6 4.1 1.6e-07 30.6 4.1 1.4 1 0 0 1 1 1 1 Sugar (and other) transporter PfkB PF00294.24 ETS61788.1 - 0.075 12.3 0.3 0.6 9.4 0.0 2.2 2 0 0 2 2 2 0 pfkB family carbohydrate kinase Zn_clus PF00172.18 ETS61791.1 - 0.00055 20.0 8.9 0.001 19.1 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Bul1_C PF04426.12 ETS61791.1 - 0.073 12.5 0.0 0.18 11.2 0.0 1.7 1 0 0 1 1 1 0 Bul1 C terminus SET PF00856.28 ETS61792.1 - 8e-15 55.6 4.5 4.3e-14 53.3 0.9 3.2 2 2 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 ETS61792.1 - 1.4e-07 32.3 0.0 6.3e-07 30.1 0.0 2.0 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding RRN3 PF05327.11 ETS61792.1 - 0.11 11.0 16.2 0.16 10.5 16.2 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 ETS61792.1 - 1.1 7.3 27.1 2 6.5 27.1 1.3 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 ETS61792.1 - 2.1 7.3 3.8 4.5 6.2 3.8 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Steroid_dh PF02544.16 ETS61793.1 - 2e-34 118.7 4.6 2.7e-34 118.3 4.6 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ubiquitin PF00240.23 ETS61793.1 - 0.00018 21.2 0.0 0.00029 20.5 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF1295 PF06966.12 ETS61793.1 - 0.0015 18.1 0.2 0.0022 17.5 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ETS61793.1 - 0.0068 16.8 1.5 0.0095 16.3 0.4 1.8 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Ubiquitin_2 PF14560.6 ETS61793.1 - 0.047 14.1 0.0 0.087 13.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain PEMT PF04191.13 ETS61793.1 - 0.057 13.8 1.4 0.17 12.3 0.4 2.0 1 1 0 2 2 2 0 Phospholipid methyltransferase YukD PF08817.10 ETS61793.1 - 0.068 13.9 0.0 0.11 13.1 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD UAE_UbL PF14732.6 ETS61793.1 - 0.11 13.1 0.1 0.2 12.3 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UN_NPL4 PF11543.8 ETS61793.1 - 0.19 12.2 0.1 0.36 11.3 0.1 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Glyco_H_20C_C PF18088.1 ETS61794.1 - 3.6e-34 118.3 0.0 2.3e-33 115.7 0.0 2.1 2 0 0 2 2 2 1 Glycoside Hydrolase 20C C-terminal domain Glyco_hydro_20 PF00728.22 ETS61794.1 - 7.1e-10 38.8 0.0 4.4e-09 36.2 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain MMS19_N PF14500.6 ETS61795.1 - 5e-68 229.5 0.0 3.6e-66 223.4 0.0 3.7 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 ETS61795.1 - 9.1e-57 193.1 0.0 2.4e-56 191.7 0.0 1.8 1 1 0 1 1 1 1 RNAPII transcription regulator C-terminal HEAT PF02985.22 ETS61795.1 - 0.099 13.0 7.0 18 5.9 0.1 6.3 6 0 0 6 6 6 0 HEAT repeat HEAT_EZ PF13513.6 ETS61795.1 - 0.16 12.5 12.4 39 4.9 0.4 7.3 6 1 1 7 7 7 0 HEAT-like repeat HEAT_2 PF13646.6 ETS61795.1 - 0.21 12.0 15.2 3.7 8.0 0.1 5.9 6 1 0 6 6 6 0 HEAT repeats Arm PF00514.23 ETS61795.1 - 0.52 10.4 4.1 25 5.1 0.0 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat AT_hook PF02178.19 ETS61796.1 - 1.8 8.7 20.9 0.079 12.9 2.6 3.7 3 0 0 3 3 3 0 AT hook motif Aminotran_5 PF00266.19 ETS61798.1 - 2.4e-25 89.3 0.0 4.8e-25 88.3 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class-V MOSC PF03473.17 ETS61798.1 - 6.7e-21 74.7 0.0 1.3e-20 73.7 0.0 1.5 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 ETS61798.1 - 9.2e-20 70.7 0.0 2.1e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Peptidase_S49 PF01343.18 ETS61799.1 - 6e-48 162.7 0.0 7.1e-27 94.2 0.0 2.9 3 0 0 3 3 3 2 Peptidase family S49 CLP_protease PF00574.23 ETS61799.1 - 2.3e-05 24.4 0.0 0.00053 19.9 0.0 2.6 2 0 0 2 2 2 1 Clp protease SDH_sah PF01972.16 ETS61799.1 - 0.025 13.6 0.0 0.062 12.3 0.0 1.6 1 0 0 1 1 1 0 Serine dehydrogenase proteinase AAA_13 PF13166.6 ETS61801.1 - 0.0061 15.3 6.8 0.0093 14.7 6.8 1.3 1 0 0 1 1 1 1 AAA domain LegC3_N PF18654.1 ETS61801.1 - 0.0062 15.8 4.6 0.0062 15.8 4.6 2.1 1 1 1 2 2 2 1 LegC3 N-terminal coiled-coil domain AAA_lid_8 PF17868.1 ETS61801.1 - 0.024 14.5 0.2 0.046 13.6 0.2 1.5 1 0 0 1 1 1 0 AAA lid domain MPS2 PF17060.5 ETS61801.1 - 0.09 12.0 7.0 0.1 11.9 6.4 1.4 1 1 0 1 1 1 0 Monopolar spindle protein 2 CC2-LZ PF16516.5 ETS61801.1 - 0.11 12.9 10.6 0.65 10.4 3.7 3.2 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Spc7 PF08317.11 ETS61801.1 - 0.29 10.0 14.4 1.9 7.3 14.4 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein Laminin_II PF06009.12 ETS61801.1 - 0.53 10.3 7.1 0.47 10.5 4.8 2.0 1 1 1 2 2 2 0 Laminin Domain II HetR_C PF18460.1 ETS61801.1 - 0.74 9.8 3.4 6.3 6.8 0.0 3.1 2 1 1 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain DUF3228 PF11539.8 ETS61801.1 - 0.77 9.2 3.1 1.2 8.6 1.2 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3228) Tup_N PF08581.10 ETS61801.1 - 0.79 10.1 10.9 23 5.4 0.1 3.2 2 1 0 2 2 2 0 Tup N-terminal KLRAQ PF10205.9 ETS61801.1 - 0.84 9.9 7.5 1.3 9.3 0.9 2.4 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein TPR_MLP1_2 PF07926.12 ETS61801.1 - 2.8 8.0 16.0 14 5.8 0.3 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 ETS61801.1 - 3 8.2 12.4 12 6.3 12.1 2.0 1 1 0 1 1 1 0 Fez1 Med9 PF07544.13 ETS61801.1 - 3.5 7.8 8.6 2.4 8.3 5.7 2.4 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 zf-C4H2 PF10146.9 ETS61801.1 - 4.1 7.7 9.1 6.4 7.0 9.1 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein V_ATPase_I PF01496.19 ETS61801.1 - 9 4.1 7.3 11 3.7 7.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec6 PF06046.13 ETS61802.1 - 8.9e-168 559.2 0.0 1.1e-167 558.9 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 NPV_P10 PF05531.12 ETS61802.1 - 0.14 12.7 0.6 1.1 9.7 0.0 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fungal_trans PF04082.18 ETS61803.1 - 1.5e-24 86.4 0.0 3e-24 85.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61803.1 - 5.6e-07 29.6 7.6 9.1e-07 28.9 7.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CN_hydrolase PF00795.22 ETS61805.1 - 1.2e-33 116.6 0.0 1.6e-33 116.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 ETS61805.1 - 1.2e-22 80.3 0.0 7e-19 67.9 0.0 2.2 2 0 0 2 2 2 2 NAD synthase MFS_1 PF07690.16 ETS61806.1 - 8.5e-29 100.6 26.6 8.5e-29 100.6 26.6 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61806.1 - 6.5e-10 38.5 2.4 6.5e-10 38.5 2.4 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter DUF4385 PF14328.6 ETS61807.1 - 9.2e-64 213.9 0.2 2e-63 212.8 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4385) GMC_oxred_N PF00732.19 ETS61808.1 - 4.3e-54 183.9 2.7 3.5e-53 180.9 2.7 2.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS61808.1 - 6.1e-29 101.4 0.0 1.1e-28 100.5 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ETS61808.1 - 1.5e-07 30.9 0.1 0.014 14.5 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ETS61808.1 - 2.8e-05 24.3 0.1 0.0001 22.4 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ETS61808.1 - 0.00012 21.2 0.0 0.00018 20.7 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 ETS61808.1 - 0.00049 19.8 0.3 0.0026 17.4 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS61808.1 - 0.00054 19.3 0.2 0.0047 16.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Endotoxin_mid PF09131.10 ETS61808.1 - 0.00062 19.5 0.9 0.0013 18.4 0.2 1.9 2 0 0 2 2 2 1 Bacillus thuringiensis delta-Endotoxin, middle domain Thi4 PF01946.17 ETS61808.1 - 0.018 14.3 0.2 0.057 12.6 0.1 1.8 2 0 0 2 2 2 0 Thi4 family Pyr_redox_3 PF13738.6 ETS61808.1 - 0.021 14.1 0.0 0.17 11.1 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS61808.1 - 0.11 13.0 0.0 0.26 11.9 0.0 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase B_lectin PF01453.24 ETS61808.1 - 0.13 12.8 0.2 0.28 11.7 0.2 1.5 1 0 0 1 1 1 0 D-mannose binding lectin RNA_pol_A_bac PF01000.26 ETS61809.1 - 5.5e-27 94.4 0.0 1.9e-26 92.6 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ETS61809.1 - 6.6e-18 63.9 0.0 9.3e-18 63.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain MIF4G PF02854.19 ETS61810.1 - 1.3e-46 158.9 0.0 1.8e-26 93.1 0.0 3.3 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 ETS61810.1 - 4.6e-25 88.9 0.6 4.6e-25 88.9 0.6 3.2 3 0 0 3 3 3 1 Up-frameshift suppressor 2 HD_2 PF12917.7 ETS61810.1 - 0.12 12.2 0.5 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 HD containing hydrolase-like enzyme ADH_N_2 PF16884.5 ETS61811.1 - 8.5e-30 102.8 0.1 2.9e-29 101.1 0.1 1.9 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 ETS61811.1 - 2.8e-24 85.6 0.0 5.4e-24 84.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS61811.1 - 3.3e-09 37.9 0.0 1.9e-08 35.5 0.0 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 ETS61811.1 - 1e-05 25.1 0.1 1.7e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NADHdh_A3 PF14987.6 ETS61813.1 - 0.018 15.3 0.5 0.023 15.0 0.5 1.2 1 0 0 1 1 1 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 AmpE PF17113.5 ETS61813.1 - 0.12 11.7 0.1 0.12 11.7 0.1 1.0 1 0 0 1 1 1 0 Regulatory signalling modulator protein AmpE CRAL_TRIO PF00650.20 ETS61814.1 - 6e-25 87.8 0.0 8.4e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ETS61814.1 - 9e-07 29.0 0.3 2.9e-06 27.4 0.1 2.0 1 1 1 2 2 2 1 CRAL/TRIO, N-terminal domain ING PF12998.7 ETS61815.1 - 5.4e-11 43.0 0.4 7.5e-11 42.5 0.4 1.2 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ETS61815.1 - 2.7e-06 27.2 7.0 4.1e-06 26.6 7.0 1.3 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETS61815.1 - 0.038 13.5 2.0 0.069 12.7 2.0 1.4 1 0 0 1 1 1 0 PHD-finger Med4 PF10018.9 ETS61815.1 - 0.071 12.8 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Tmemb_cc2 PF10267.9 ETS61815.1 - 0.13 11.4 0.1 0.18 10.9 0.1 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein CMS1 PF14617.6 ETS61816.1 - 6.5e-52 176.4 8.0 1e-25 90.5 0.0 2.3 1 1 2 3 3 3 2 U3-containing 90S pre-ribosomal complex subunit DUF4770 PF15994.5 ETS61816.1 - 0.6 10.3 3.4 16 5.7 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Rrn6 PF10214.9 ETS61816.1 - 0.69 8.3 5.8 1 7.8 5.8 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Med19 PF10278.9 ETS61816.1 - 0.99 9.3 8.7 0.59 10.0 4.7 2.1 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 RNA_polI_A34 PF08208.11 ETS61816.1 - 1.2 9.1 13.3 1.3 9.1 8.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4451 PF14616.6 ETS61818.1 - 3.6e-30 104.7 0.3 5.8e-30 104.0 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) DUF3040 PF11239.8 ETS61819.1 - 0.024 14.9 0.2 0.093 13.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) BAR_2 PF10455.9 ETS61820.1 - 1e-45 156.1 0.5 1.7e-45 155.4 0.5 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 ETS61820.1 - 5.9e-21 75.2 5.9 2.4e-16 60.1 2.9 2.1 2 0 0 2 2 2 2 BAR domain BAR_3 PF16746.5 ETS61820.1 - 0.021 14.6 2.7 0.03 14.0 0.6 2.0 2 0 0 2 2 2 0 BAR domain of APPL family Seryl_tRNA_N PF02403.22 ETS61820.1 - 0.042 14.1 5.1 19 5.5 0.0 3.4 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.16 ETS61820.1 - 0.061 13.8 2.8 0.12 12.8 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function DUF16 Sec8_exocyst PF04048.14 ETS61820.1 - 0.1 12.5 2.6 0.78 9.6 1.1 2.9 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain GIDA_assoc PF13932.6 ETS61820.1 - 0.11 12.6 2.9 0.34 11.1 0.6 2.1 2 0 0 2 2 2 0 GidA associated domain PCRF PF03462.18 ETS61820.1 - 0.14 12.0 4.8 3.1 7.6 0.1 2.4 2 0 0 2 2 2 0 PCRF domain Uds1 PF15456.6 ETS61820.1 - 0.28 11.3 8.4 0.45 10.7 0.0 3.0 2 1 0 2 2 2 0 Up-regulated During Septation DUF3450 PF11932.8 ETS61820.1 - 0.4 9.9 11.3 5.3 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) TMF_DNA_bd PF12329.8 ETS61820.1 - 0.42 10.6 7.3 2.6 8.1 0.1 3.6 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 ETS61820.1 - 2.4 8.3 4.0 16 5.7 1.2 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Spectrin PF00435.21 ETS61820.1 - 2.6 8.6 7.6 2.6 8.6 0.2 3.0 2 2 0 2 2 2 0 Spectrin repeat HSCB_C PF07743.13 ETS61820.1 - 6.1 7.4 10.8 0.96 10.0 1.3 3.3 2 1 1 3 3 3 0 HSCB C-terminal oligomerisation domain ATG16 PF08614.11 ETS61820.1 - 8.4 6.6 13.8 1.3 9.2 5.5 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) OTCace PF00185.24 ETS61821.1 - 1.5e-45 155.1 0.0 2.7e-45 154.3 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 ETS61821.1 - 2.4e-44 150.9 0.1 4.1e-44 150.2 0.1 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Aminotran_1_2 PF00155.21 ETS61821.1 - 9.8e-16 57.9 0.0 1.5e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II F-box-like PF12937.7 ETS61824.1 - 0.034 14.0 0.4 0.1 12.5 0.4 1.9 1 0 0 1 1 1 0 F-box-like Ribosomal_L14 PF00238.19 ETS61825.1 - 4.2e-36 123.7 0.1 4.9e-36 123.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e F-box-like PF12937.7 ETS61826.1 - 0.029 14.3 0.4 0.058 13.3 0.4 1.5 1 0 0 1 1 1 0 F-box-like tRNA-synt_1g PF09334.11 ETS61827.1 - 2e-150 500.9 0.0 2.5e-150 500.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ETS61827.1 - 1e-06 27.3 0.5 0.00026 19.4 0.0 3.5 2 2 1 3 3 3 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ETS61827.1 - 0.00092 19.2 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA HypA PF01155.19 ETS61827.1 - 0.036 14.1 4.4 1.6 8.8 0.2 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 ETS61827.1 - 1.9 8.6 10.0 1.2 9.2 6.5 2.2 1 1 1 2 2 2 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ETS61827.1 - 2.1 8.4 7.0 6.5 6.8 6.8 1.8 1 1 0 1 1 1 0 zinc-ribbons Zn-ribbon_8 PF09723.10 ETS61827.1 - 9.5 6.4 9.2 6.6 6.9 1.5 2.6 2 0 0 2 2 2 0 Zinc ribbon domain Pam16 PF03656.13 ETS61828.1 - 4.3e-18 65.6 0.6 5.6e-17 61.9 0.6 2.1 1 1 0 1 1 1 1 Pam16 Arg_decarbox_C PF17944.1 ETS61828.1 - 0.081 13.5 0.0 0.19 12.3 0.0 1.6 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension Ribosomal_L3 PF00297.22 ETS61829.1 - 1.8e-19 70.0 3.0 5.3e-17 61.8 2.0 2.3 1 1 1 2 2 2 2 Ribosomal protein L3 Gln-synt_C PF00120.24 ETS61830.1 - 9.7e-17 61.0 0.0 2.6e-15 56.3 0.0 2.1 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ETS61830.1 - 4.6e-12 45.5 0.0 8.1e-12 44.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain QCR10 PF09796.9 ETS61831.1 - 1.6e-23 82.5 0.9 1.9e-23 82.3 0.9 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Zn_clus PF00172.18 ETS61832.1 - 5.6e-05 23.2 10.1 9e-05 22.5 10.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cu_amine_oxid PF01179.20 ETS61833.1 - 1.5e-152 508.3 0.3 1.8e-152 508.0 0.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 ETS61833.1 - 2.6e-13 50.2 0.0 4.9e-13 49.4 0.0 1.5 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 ETS61833.1 - 0.00013 22.2 0.0 0.00032 20.9 0.0 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Aldedh PF00171.22 ETS61834.1 - 3.7e-176 586.2 0.5 4.2e-176 586.0 0.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family AA_permease_2 PF13520.6 ETS61835.1 - 6.2e-55 186.7 57.3 7.8e-55 186.4 57.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS61835.1 - 4.5e-17 61.8 51.8 7.4e-17 61.1 51.8 1.3 1 0 0 1 1 1 1 Amino acid permease CENP-I PF07778.11 ETS61836.1 - 5.5e-08 32.0 0.6 1.8e-07 30.3 0.6 1.8 1 0 0 1 1 1 1 Mis6 Nop14 PF04147.12 ETS61836.1 - 4.1 5.5 14.8 8.6 4.4 14.8 1.4 1 0 0 1 1 1 0 Nop14-like family TB2_DP1_HVA22 PF03134.19 ETS61837.1 - 8.4e-29 99.3 7.0 1.7e-28 98.4 7.0 1.5 1 0 0 1 1 1 1 TB2/DP1, HVA22 family EcsC PF12787.7 ETS61837.1 - 0.52 9.9 2.3 0.84 9.3 1.9 1.5 1 1 1 2 2 2 0 EcsC protein family F-box-like PF12937.7 ETS61838.1 - 1.9e-12 46.9 0.2 4e-12 45.8 0.2 1.6 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 ETS61838.1 - 6.8e-10 39.4 0.5 0.00034 21.4 0.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat F-box PF00646.33 ETS61838.1 - 1.1e-09 37.9 0.2 3.4e-09 36.4 0.2 1.8 1 0 0 1 1 1 1 F-box domain HAD_2 PF13419.6 ETS61838.1 - 8.9e-07 29.2 0.0 1.4e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase NAD_binding_10 PF13460.6 ETS61839.1 - 1.7e-32 112.8 0.1 1.4e-29 103.3 0.0 2.2 2 0 0 2 2 2 2 NAD(P)H-binding Pectinesterase PF01095.19 ETS61839.1 - 2e-29 102.3 0.2 2.5e-28 98.7 0.2 2.0 1 1 0 1 1 1 1 Pectinesterase Epimerase PF01370.21 ETS61839.1 - 0.00071 19.1 0.0 0.004 16.7 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ETS61839.1 - 0.045 13.3 0.1 0.072 12.6 0.1 1.3 1 0 0 1 1 1 0 NmrA-like family Aminotran_1_2 PF00155.21 ETS61840.1 - 1.2e-41 143.2 0.0 1.8e-41 142.6 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ETS61840.1 - 0.00033 19.3 0.0 0.00068 18.3 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ETS61840.1 - 0.12 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Fungal_trans PF04082.18 ETS61841.1 - 7.2e-11 41.6 0.0 1.5e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61841.1 - 1.2e-05 25.4 12.7 2.1e-05 24.5 12.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_23 PF13489.6 ETS61842.1 - 1.5e-10 41.1 0.0 2e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS61842.1 - 4.9e-06 27.1 0.0 7.9e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS61842.1 - 1.3e-05 25.1 0.0 4.2e-05 23.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS61842.1 - 1.7e-05 25.5 0.0 3.7e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS61842.1 - 0.0032 18.1 0.0 0.0055 17.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 ETS61842.1 - 0.0036 17.1 0.0 0.0052 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) tRNA-synt_1 PF00133.22 ETS61843.1 - 9.4e-221 734.2 0.0 9.8e-220 730.8 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ETS61843.1 - 6.5e-37 126.8 1.1 1.3e-36 125.9 0.6 1.7 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ETS61843.1 - 1.8e-15 56.6 0.2 3.3e-07 29.4 0.1 4.4 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ETS61843.1 - 1.7e-11 43.9 4.0 1.8e-07 30.8 0.1 3.1 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ETS61843.1 - 0.0054 16.1 0.0 0.62 9.4 0.0 2.6 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1b PF00579.25 ETS61843.1 - 0.11 11.8 0.0 1.4 8.2 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) tRNA-synt_1c PF00749.21 ETS61843.1 - 0.17 10.8 0.2 1.8 7.4 0.1 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain Val_tRNA-synt_C PF10458.9 ETS61843.1 - 1.1 9.5 9.9 0.059 13.7 2.7 2.7 2 0 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm Ribosomal_S8e PF01201.22 ETS61844.1 - 1.7e-54 183.7 1.3 3.3e-54 182.8 1.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S8e bZIP_1 PF00170.21 ETS61847.1 - 1.9e-08 34.3 14.4 3e-08 33.6 14.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ETS61847.1 - 1.7e-07 31.2 10.1 1.7e-07 31.2 10.1 1.9 1 1 1 2 2 2 1 Basic region leucine zipper HAUS4 PF14735.6 ETS61847.1 - 0.006 16.3 1.5 0.011 15.5 1.5 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 4 Prp31_C PF09785.9 ETS61847.1 - 0.038 14.9 0.8 0.079 13.9 0.8 1.5 1 0 0 1 1 1 0 Prp31 C terminal domain Macoilin PF09726.9 ETS61847.1 - 0.7 8.4 14.4 1.4 7.4 14.4 1.4 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 ETS61847.1 - 1.3 7.2 9.9 2.7 6.2 9.9 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FAM176 PF14851.6 ETS61847.1 - 1.4 8.6 8.2 3.5 7.3 8.2 1.6 1 0 0 1 1 1 0 FAM176 family DUF2096 PF09869.9 ETS61848.1 - 0.12 12.4 0.5 1.8 8.6 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) MFS_1 PF07690.16 ETS61849.1 - 5.1e-29 101.3 33.3 1e-28 100.3 32.3 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily SAC3_GANP PF03399.16 ETS61850.1 - 9.1e-100 333.8 0.0 1.3e-99 333.3 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 ETS61850.1 - 0.02 14.9 1.1 0.31 11.0 0.0 2.5 3 0 0 3 3 3 0 CSN8/PSMD8/EIF3K family PNP_UDP_1 PF01048.20 ETS61852.1 - 2.8e-25 89.0 0.1 3.6e-25 88.6 0.1 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily Band_7 PF01145.25 ETS61853.1 - 4.8e-23 82.1 6.3 1.2e-22 80.8 6.0 1.7 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 ETS61853.1 - 0.0021 17.2 3.6 0.0026 16.9 3.6 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial AAA_lid_4 PF17864.1 ETS61853.1 - 0.081 12.7 4.2 0.11 12.3 0.2 2.7 1 1 2 3 3 3 0 RuvB AAA lid domain tRNA-synt_2b PF00587.25 ETS61854.1 - 1.4e-17 64.2 0.0 9.3e-17 61.6 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) FLILHELTA PF10306.9 ETS61854.1 - 1.6e-17 63.7 0.0 4.2e-17 62.3 0.0 1.8 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA HORMA PF02301.18 ETS61854.1 - 0.017 14.7 0.5 0.034 13.7 0.5 1.5 1 0 0 1 1 1 0 HORMA domain DUF1279 PF06916.13 ETS61854.1 - 0.049 14.2 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) Sec8_exocyst PF04048.14 ETS61854.1 - 0.086 12.7 1.0 0.21 11.4 1.0 1.6 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Beta_propel PF09826.9 ETS61854.1 - 0.26 10.1 1.9 0.36 9.6 1.9 1.1 1 0 0 1 1 1 0 Beta propeller domain DNA_topoisoIV PF00521.20 ETS61855.1 - 4.2e-129 431.2 0.0 1.1e-128 429.8 0.0 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ETS61855.1 - 9.6e-54 181.1 1.0 3.1e-53 179.4 1.0 2.0 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ETS61855.1 - 3e-28 98.4 1.3 5.7e-28 97.5 1.3 1.4 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 ETS61855.1 - 7.1e-14 52.3 0.0 1.9e-13 50.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ETS61855.1 - 8.1e-09 35.6 0.0 3.2e-08 33.7 0.0 2.1 1 0 0 1 1 1 1 Toprim domain Asn_synthase PF00733.21 ETS61856.1 - 3e-20 73.2 1.9 1.2e-08 35.0 0.1 3.2 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 ETS61856.1 - 1.6e-08 34.5 0.0 3.2e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ETS61856.1 - 1.5e-07 31.6 0.0 3.7e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain ATP_bind_3 PF01171.20 ETS61856.1 - 0.12 12.1 0.0 11 5.7 0.0 2.3 2 0 0 2 2 2 0 PP-loop family Chs7 PF12271.8 ETS61857.1 - 8.4e-115 383.1 16.6 9.7e-115 382.8 16.6 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone WD40 PF00400.32 ETS61858.1 - 1.7e-31 107.7 14.0 7.7e-06 26.5 0.3 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETS61858.1 - 1.4e-09 37.2 0.3 0.00023 19.9 0.0 4.1 4 1 1 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETS61858.1 - 3.4e-05 24.1 0.0 4.4 7.7 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CENP-F_leu_zip PF10473.9 ETS61858.1 - 0.066 13.2 5.0 0.12 12.4 5.0 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WD40_like PF17005.5 ETS61858.1 - 0.26 10.6 0.0 1.7 7.9 0.0 2.1 3 0 0 3 3 3 0 WD40-like domain AAA_22 PF13401.6 ETS61859.1 - 1.3e-17 64.4 0.0 4.1e-17 62.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ETS61859.1 - 1.7e-09 38.2 0.0 4.1e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ETS61859.1 - 1.3e-08 34.5 0.0 2.6e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein NACHT PF05729.12 ETS61859.1 - 1.6e-08 34.6 0.0 4e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETS61859.1 - 7.1e-07 29.8 0.3 7.1e-07 29.8 0.3 3.3 3 2 0 3 3 2 1 AAA ATPase domain NB-ARC PF00931.22 ETS61859.1 - 0.0015 17.8 0.0 0.0027 16.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_lid_10 PF17872.1 ETS61859.1 - 0.0075 16.4 0.2 0.017 15.2 0.2 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_33 PF13671.6 ETS61859.1 - 0.0099 16.0 0.3 0.047 13.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ETS61859.1 - 0.017 15.0 0.0 0.091 12.7 0.0 2.0 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ETS61859.1 - 0.038 13.7 0.0 8.3 6.1 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_19 PF13245.6 ETS61859.1 - 0.045 14.1 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_assoc_2 PF16193.5 ETS61859.1 - 0.077 13.3 1.2 0.36 11.2 1.2 2.1 1 0 0 1 1 1 0 AAA C-terminal domain FAD_SOX PF18371.1 ETS61859.1 - 0.1 13.0 0.0 0.98 9.8 0.0 2.4 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase KH_1 PF00013.29 ETS61860.1 - 0.017 14.9 0.4 0.037 13.9 0.4 1.5 1 0 0 1 1 1 0 KH domain KH_8 PF17903.1 ETS61860.1 - 0.045 13.9 0.0 0.077 13.1 0.0 1.3 1 0 0 1 1 1 0 Krr1 KH1 domain Choline_transpo PF04515.12 ETS61861.1 - 6e-58 196.6 16.6 8.8e-57 192.8 13.1 2.9 2 1 0 2 2 2 2 Plasma-membrane choline transporter PCI PF01399.27 ETS61862.1 - 5.3e-05 23.7 0.1 0.00011 22.7 0.1 1.6 1 0 0 1 1 1 1 PCI domain ParB PF08775.10 ETS61862.1 - 0.0097 16.4 1.7 0.025 15.0 1.4 1.8 2 0 0 2 2 2 1 ParB family Spc7 PF08317.11 ETS61862.1 - 0.033 13.1 4.1 0.062 12.2 4.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein COG2 PF06148.11 ETS61862.1 - 0.045 13.8 0.8 0.11 12.6 0.8 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 STAG PF08514.11 ETS61862.1 - 0.15 11.9 2.9 0.32 10.9 2.9 1.6 1 0 0 1 1 1 0 STAG domain DUF3692 PF12469.8 ETS61862.1 - 0.16 12.2 0.7 1.5 9.0 0.0 2.3 2 1 0 2 2 2 0 CRISPR-associated protein DDHD PF02862.17 ETS61862.1 - 2.7 8.1 5.9 3.6 7.7 3.6 2.0 2 0 0 2 2 2 0 DDHD domain Pkinase PF00069.25 ETS61863.1 - 5.4e-57 193.1 0.0 2.4e-56 191.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61863.1 - 5.7e-28 97.9 0.0 1.9e-21 76.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS61863.1 - 1.5e-06 27.7 0.0 2.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETS61863.1 - 0.028 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ETS61863.1 - 0.066 12.2 0.1 0.17 10.9 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 PA_decarbox PF05870.11 ETS61864.1 - 6.1e-09 35.7 0.1 7.2e-09 35.5 0.1 1.2 1 0 0 1 1 1 1 Phenolic acid decarboxylase (PAD) ParA PF10609.9 ETS61865.1 - 2.4e-88 295.8 0.0 3e-88 295.4 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ETS61865.1 - 1.2e-05 25.4 0.0 3.7e-05 23.8 0.0 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 ETS61865.1 - 2.4e-05 23.7 1.4 0.00016 21.0 0.3 2.4 2 1 1 3 3 3 1 Anion-transporting ATPase AAA_31 PF13614.6 ETS61865.1 - 0.00025 21.0 0.0 0.058 13.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain zf-C4_ClpX PF06689.13 ETS61865.1 - 0.0021 17.9 0.6 0.0041 17.0 0.6 1.4 1 0 0 1 1 1 1 ClpX C4-type zinc finger AAA_26 PF13500.6 ETS61865.1 - 0.0044 16.9 0.0 0.53 10.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 ETS61865.1 - 0.022 14.1 0.0 0.06 12.6 0.0 1.7 1 1 0 1 1 1 0 ATPase MipZ AAA_16 PF13191.6 ETS61865.1 - 0.098 13.0 0.4 0.36 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_25 PF13481.6 ETS61865.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ETS61865.1 - 0.16 11.1 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain LapA_dom PF06305.11 ETS61866.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EMP24_GP25L PF01105.24 ETS61867.1 - 1.8e-45 155.1 0.0 2.3e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Voltage_CLC PF00654.20 ETS61868.1 - 2.1e-90 303.5 28.9 4.4e-90 302.5 28.9 1.5 1 0 0 1 1 1 1 Voltage gated chloride channel Pro_isomerase PF00160.21 ETS61868.1 - 5.6e-32 111.2 0.0 9.6e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ETS61868.1 - 2.2e-15 56.2 0.0 6e-15 54.8 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CBS PF00571.28 ETS61868.1 - 8.7e-08 32.5 0.0 1.5e-05 25.3 0.1 2.9 2 0 0 2 2 2 1 CBS domain TFIIA PF03153.13 ETS61868.1 - 2 8.3 6.9 1.8 8.4 0.5 2.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit LRRFIP PF09738.9 ETS61869.1 - 0.66 9.4 4.4 0.79 9.1 4.4 1.0 1 0 0 1 1 1 0 LRRFIP family MutL_C PF08676.11 ETS61870.1 - 1.1e-06 28.5 0.1 1.2e-05 25.1 0.0 2.1 2 0 0 2 2 2 1 MutL C terminal dimerisation domain PEN-2 PF10251.9 ETS61873.1 - 0.043 14.2 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase SUIM_assoc PF16619.5 ETS61873.1 - 0.9 9.7 6.1 5.1 7.2 6.1 2.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PCI PF01399.27 ETS61874.1 - 2.4e-09 37.6 0.0 4.4e-09 36.8 0.0 1.4 1 0 0 1 1 1 1 PCI domain TIP120 PF08623.10 ETS61875.1 - 4.6e-52 176.2 2.1 2.4e-50 170.6 0.1 3.8 4 1 0 4 4 4 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 ETS61875.1 - 2.1e-11 44.0 34.2 0.00011 22.5 0.5 9.7 7 5 4 11 11 11 4 HEAT repeats HEAT PF02985.22 ETS61875.1 - 4.1e-07 29.7 32.5 0.6 10.5 0.2 12.3 14 0 0 14 14 14 4 HEAT repeat HEAT_EZ PF13513.6 ETS61875.1 - 4.8e-05 23.8 32.7 1.5 9.4 0.1 10.9 12 0 0 12 12 12 3 HEAT-like repeat Cnd1 PF12717.7 ETS61875.1 - 0.00048 20.2 9.4 0.26 11.3 2.1 4.5 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd3 PF12719.7 ETS61875.1 - 0.0066 15.7 6.7 0.033 13.4 0.1 3.9 4 1 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain RNA_pol_3_Rpc31 PF11705.8 ETS61875.1 - 4.9 7.3 11.8 8.3 6.6 11.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 GCIP PF13324.6 ETS61875.1 - 7.3 6.1 8.9 2 7.9 2.0 2.4 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting PHO4 PF01384.20 ETS61876.1 - 8.7e-116 386.6 16.9 8.7e-116 386.6 16.9 1.4 2 0 0 2 2 2 1 Phosphate transporter family KR PF08659.10 ETS61876.1 - 0.071 13.0 0.2 0.17 11.8 0.2 1.6 1 0 0 1 1 1 0 KR domain MFS_1 PF07690.16 ETS61879.1 - 4.4e-32 111.4 42.1 9.7e-30 103.7 25.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5357 PF17310.2 ETS61879.1 - 0.14 10.7 3.4 2.8 6.4 0.1 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5357) LacI PF00356.21 ETS61882.1 - 0.12 12.2 1.0 0.41 10.5 1.0 1.9 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Cation_ATPase_C PF00689.21 ETS61883.1 - 3.4e-47 160.5 6.3 3.4e-47 160.5 6.3 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ETS61883.1 - 1.3e-37 129.0 0.1 1.3e-37 129.0 0.1 2.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 ETS61883.1 - 1.2e-20 73.4 0.1 2.7e-20 72.3 0.1 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETS61883.1 - 1e-16 61.9 6.1 4.3e-16 59.8 6.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ETS61883.1 - 5e-08 32.5 0.4 1.8e-06 27.5 0.1 2.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ETS61883.1 - 0.00076 19.3 0.2 0.021 14.6 0.3 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Phosphodiest PF01663.22 ETS61884.1 - 2.2e-08 34.1 1.3 4.1e-08 33.2 1.3 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ETS61884.1 - 0.045 13.1 1.9 0.081 12.3 1.9 1.3 1 0 0 1 1 1 0 Metalloenzyme superfamily PglZ PF08665.12 ETS61884.1 - 0.59 10.2 3.6 8.9 6.4 0.4 2.2 2 0 0 2 2 2 0 PglZ domain SUR7 PF06687.12 ETS61885.1 - 3.3e-18 66.1 3.6 4.7e-18 65.6 3.6 1.2 1 0 0 1 1 1 1 SUR7/PalI family Ninjurin PF04923.12 ETS61885.1 - 0.031 14.2 1.2 0.11 12.4 0.1 2.2 2 0 0 2 2 2 0 Ninjurin RseC_MucC PF04246.12 ETS61885.1 - 0.074 13.0 0.4 0.074 13.0 0.4 1.8 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC T4SS_CagC PF16943.5 ETS61885.1 - 0.28 11.4 4.4 0.6 10.3 4.4 1.6 1 1 0 1 1 1 0 Cag pathogenicity island, type IV secretory system Clc-like PF07062.12 ETS61885.1 - 0.34 10.4 7.2 0.023 14.2 1.8 1.7 2 0 0 2 2 2 0 Clc-like Claudin_3 PF06653.11 ETS61885.1 - 0.88 9.5 5.1 0.21 11.5 1.0 1.8 2 0 0 2 2 2 0 Tight junction protein, Claudin-like Amastin PF07344.11 ETS61885.1 - 1.2 9.0 7.3 0.44 10.4 3.5 2.1 2 0 0 2 2 2 0 Amastin surface glycoprotein Abhydrolase_9_N PF15420.6 ETS61885.1 - 3.2 7.7 9.2 0.16 11.9 3.5 1.8 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Ribosomal_S7 PF00177.21 ETS61886.1 - 4.8e-36 123.7 0.8 7.3e-36 123.1 0.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Myb_DNA-binding PF00249.31 ETS61887.1 - 5.7e-25 87.3 0.0 3.9e-13 49.4 0.1 5.1 5 1 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETS61887.1 - 3.1e-15 56.2 0.0 1.6e-05 25.0 0.0 4.7 4 1 1 5 5 5 3 Myb-like DNA-binding domain SelB-wing_3 PF09107.11 ETS61887.1 - 0.061 13.0 0.0 0.2 11.3 0.0 1.9 1 0 0 1 1 1 0 Elongation factor SelB, winged helix DUF3192 PF11399.8 ETS61887.1 - 0.24 11.4 0.5 0.73 9.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3192) Peptidase_S10 PF00450.22 ETS61888.1 - 1.3e-98 331.2 0.0 1.7e-98 330.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase CN_hydrolase PF00795.22 ETS61889.1 - 3.8e-21 75.6 0.0 6.3e-16 58.5 0.0 2.1 2 0 0 2 2 2 2 Carbon-nitrogen hydrolase SOG2 PF10428.9 ETS61890.1 - 0.12 11.6 7.2 0.15 11.2 7.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein IPP-2 PF04979.14 ETS61891.1 - 7.8e-20 72.0 4.7 3e-18 66.8 4.7 2.1 1 1 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) SWIRM-assoc_2 PF16496.5 ETS61891.1 - 0.0022 17.0 4.5 0.0022 17.0 4.5 1.8 2 0 0 2 2 2 1 SWIRM-associated domain at the N-terminal PPP4R2 PF09184.11 ETS61891.1 - 0.099 12.2 3.0 0.15 11.6 3.0 1.2 1 0 0 1 1 1 0 PPP4R2 CDC27 PF09507.10 ETS61891.1 - 0.72 9.2 8.5 0.69 9.2 8.2 1.4 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 DLIC PF05783.11 ETS61892.1 - 3.7e-55 187.6 12.8 2.6e-28 99.1 0.0 6.9 5 1 1 7 7 7 6 Dynein light intermediate chain (DLIC) MCM PF00493.23 ETS61892.1 - 0.0058 15.7 0.1 0.01 15.0 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain AAA_16 PF13191.6 ETS61892.1 - 0.0061 17.0 0.3 0.0061 17.0 0.3 2.5 2 1 1 3 3 3 1 AAA ATPase domain MMR_HSR1 PF01926.23 ETS61892.1 - 0.023 14.8 0.0 0.052 13.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS61892.1 - 0.073 13.0 0.4 3.2 7.6 0.3 2.3 2 0 0 2 2 2 0 RsgA GTPase DUF2813 PF11398.8 ETS61892.1 - 0.088 12.1 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) Pkr1 PF08636.10 ETS61893.1 - 4e-26 90.9 2.7 4.7e-26 90.7 2.7 1.1 1 0 0 1 1 1 1 ER protein Pkr1 UPF0154 PF03672.13 ETS61893.1 - 0.0073 16.3 0.0 0.012 15.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0154) DUF5317 PF17248.2 ETS61893.1 - 0.0084 16.1 0.2 0.0096 15.9 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5317) DUF5531 PF17671.1 ETS61893.1 - 0.043 13.7 0.3 0.056 13.3 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5531) PhoR PF11808.8 ETS61893.1 - 0.2 12.1 2.6 4.5 7.8 1.9 2.2 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR OAD_gamma PF04277.13 ETS61893.1 - 5.2 7.7 6.2 63 4.3 6.2 2.0 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF802 PF05650.11 ETS61896.1 - 1.1 9.7 6.2 0.12 12.9 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF802) DUF676 PF05057.14 ETS61897.1 - 2e-31 109.2 0.0 9.9e-31 106.9 0.0 1.9 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 ETS61897.1 - 0.0016 19.1 6.5 0.018 15.7 6.5 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ETS61897.1 - 0.083 12.4 0.0 0.36 10.3 0.0 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family MAP65_ASE1 PF03999.12 ETS61897.1 - 1 8.0 3.8 0.94 8.1 2.0 1.5 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) ABC_tran PF00005.27 ETS61898.1 - 7.6e-48 162.5 0.0 1.3e-23 84.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 ETS61898.1 - 5e-20 71.9 29.4 1e-12 47.8 5.4 2.5 3 0 0 3 3 3 2 ABC-2 family transporter protein AAA_21 PF13304.6 ETS61898.1 - 1e-11 45.2 11.3 0.00022 21.2 0.0 5.0 6 0 0 6 6 6 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETS61898.1 - 1.2e-05 24.9 0.0 0.69 9.3 0.0 3.6 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS61898.1 - 0.0014 18.4 1.4 0.049 13.4 0.3 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain SRP54 PF00448.22 ETS61898.1 - 0.029 14.0 1.7 2.9 7.5 0.1 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 ETS61898.1 - 0.18 12.3 1.1 1.9 9.0 0.2 2.3 2 0 0 2 2 2 0 AAA domain MukB PF04310.12 ETS61898.1 - 0.23 11.2 1.1 19 4.9 0.1 2.6 2 0 0 2 2 2 0 MukB N-terminal DUF87 PF01935.17 ETS61898.1 - 1.6 8.8 5.7 3.3 7.7 0.3 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain CN_hydrolase PF00795.22 ETS61899.1 - 3.4e-43 147.9 0.0 5.4e-43 147.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase LSM PF01423.22 ETS61901.1 - 7.5e-07 28.8 0.0 1e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ETS61901.1 - 0.0011 19.1 0.1 0.0016 18.6 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain NMO PF03060.15 ETS61902.1 - 2.1e-53 181.9 0.1 3.3e-53 181.2 0.1 1.3 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 ETS61902.1 - 1.3e-13 50.6 0.6 2.1e-13 50.0 0.6 1.3 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 ETS61902.1 - 3e-05 23.2 2.0 4.8e-05 22.6 2.0 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NanE PF04131.14 ETS61902.1 - 0.18 11.0 0.9 0.32 10.2 0.1 1.8 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Phage_P2_GpE PF06528.12 ETS61904.1 - 0.2 11.2 0.5 1.5 8.4 0.0 2.2 2 0 0 2 2 2 0 Phage P2 GpE SPX PF03105.19 ETS61904.1 - 4.3 7.2 7.9 5.8 6.7 7.9 1.1 1 0 0 1 1 1 0 SPX domain AAA_18 PF13238.6 ETS61905.1 - 7.2e-26 91.3 0.0 1.8e-25 90.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETS61905.1 - 0.00084 19.6 2.7 0.0027 18.0 2.3 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETS61905.1 - 0.0066 16.7 0.0 0.01 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ETS61905.1 - 0.024 14.3 0.0 0.39 10.4 0.0 2.1 2 0 0 2 2 2 0 Thymidylate kinase ABC_tran PF00005.27 ETS61905.1 - 0.029 14.9 0.0 0.051 14.1 0.0 1.4 1 1 0 1 1 1 0 ABC transporter KTI12 PF08433.10 ETS61905.1 - 0.047 13.1 0.0 0.075 12.5 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 ETS61905.1 - 0.048 14.1 0.0 0.071 13.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_17 PF13207.6 ETS61905.1 - 0.091 13.2 0.6 6 7.3 0.1 2.5 1 1 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ETS61905.1 - 0.099 12.5 0.5 0.3 11.0 0.1 2.0 3 0 0 3 3 3 0 NTPase AAA_33 PF13671.6 ETS61905.1 - 0.1 12.7 1.5 4.9 7.3 0.2 2.7 2 1 1 3 3 3 0 AAA domain DUF927 PF06048.11 ETS61905.1 - 0.13 11.8 0.6 0.21 11.1 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF927) ADK PF00406.22 ETS61905.1 - 0.13 12.3 0.2 7.4 6.7 0.1 2.2 2 0 0 2 2 2 0 Adenylate kinase dNK PF01712.19 ETS61905.1 - 0.13 12.1 0.1 17 5.2 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase FtsK_SpoIIIE PF01580.18 ETS61905.1 - 0.17 11.2 0.3 0.4 10.0 0.1 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 ETS61905.1 - 0.19 11.5 0.4 0.49 10.1 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ETS61905.1 - 0.19 12.1 0.1 0.33 11.4 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 ETS61906.1 - 7.7e-108 360.0 0.5 1.1e-107 359.5 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ETS61906.1 - 2.4e-08 34.0 0.0 6.7e-08 32.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS61906.1 - 7.1e-05 22.4 0.6 0.0014 18.2 0.1 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETS61906.1 - 0.00012 22.1 0.7 0.0086 16.0 0.6 3.0 2 1 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 ETS61906.1 - 0.002 18.2 5.7 0.14 12.2 0.1 3.1 2 1 1 3 3 3 2 Dynamin family AAA_23 PF13476.6 ETS61906.1 - 0.0026 18.3 7.9 0.41 11.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ETS61906.1 - 0.0036 16.7 0.1 0.0071 15.7 0.1 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_24 PF13479.6 ETS61906.1 - 0.0039 16.9 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AIG1 PF04548.16 ETS61906.1 - 0.0046 16.3 0.0 0.011 15.1 0.0 1.6 1 0 0 1 1 1 1 AIG1 family AAA_33 PF13671.6 ETS61906.1 - 0.0063 16.7 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETS61906.1 - 0.009 16.4 0.0 0.026 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 ETS61906.1 - 0.013 15.8 2.4 0.12 12.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain IIGP PF05049.13 ETS61906.1 - 0.014 14.5 1.2 0.027 13.6 0.1 2.0 2 1 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.6 ETS61906.1 - 0.017 15.4 1.9 0.04 14.2 0.0 2.4 3 1 0 3 3 3 0 AAA domain Roc PF08477.13 ETS61906.1 - 0.024 14.9 0.0 0.063 13.5 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETS61906.1 - 0.037 14.6 0.4 0.13 12.8 0.0 2.1 2 1 0 2 2 2 0 ABC transporter AAA_25 PF13481.6 ETS61906.1 - 0.045 13.3 0.0 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETS61906.1 - 0.063 13.6 0.1 0.3 11.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain Ras PF00071.22 ETS61906.1 - 0.082 12.5 0.3 0.4 10.3 0.0 2.2 2 0 0 2 2 2 0 Ras family RNA_helicase PF00910.22 ETS61906.1 - 0.088 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 ETS61906.1 - 0.13 12.8 2.5 0.39 11.3 0.0 2.7 2 1 0 3 3 3 0 AAA domain NACHT PF05729.12 ETS61906.1 - 0.13 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain DUF87 PF01935.17 ETS61906.1 - 4 7.5 7.2 3.6 7.6 0.4 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain TPK_catalytic PF04263.16 ETS61907.1 - 8e-29 100.1 0.0 1.4e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ETS61907.1 - 4.1e-20 71.3 0.0 7e-20 70.5 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Lactamase_B_2 PF12706.7 ETS61907.1 - 1e-10 41.5 0.0 2.3e-08 33.8 0.0 3.0 3 0 0 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ETS61907.1 - 6.8e-07 29.5 0.1 1.9e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ETS61907.1 - 0.055 12.9 0.0 0.09 12.2 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Lactamase_B_4 PF13691.6 ETS61907.1 - 0.1 12.3 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 tRNase Z endonuclease Spindle_Spc25 PF08234.12 ETS61908.1 - 5.4e-22 77.8 0.1 1e-21 76.9 0.1 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 ETS61908.1 - 0.0053 15.7 14.1 0.0053 15.7 14.1 2.3 2 1 0 2 2 2 1 Spc7 kinetochore protein HAP1_N PF04849.13 ETS61908.1 - 0.0091 15.2 11.6 0.0091 15.2 11.6 1.6 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Cortex-I_coil PF09304.10 ETS61908.1 - 0.013 15.7 15.6 0.013 15.7 15.6 1.9 2 0 0 2 2 2 0 Cortexillin I, coiled coil CALCOCO1 PF07888.11 ETS61908.1 - 0.075 11.9 22.9 0.17 10.7 22.9 1.5 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HAUS-augmin3 PF14932.6 ETS61908.1 - 0.22 11.0 18.8 0.034 13.7 14.6 1.7 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 Syntaxin-6_N PF09177.11 ETS61908.1 - 1.9 9.1 11.5 0.17 12.5 3.4 2.7 2 1 1 3 3 3 0 Syntaxin 6, N-terminal FapA PF03961.13 ETS61908.1 - 2 7.0 12.2 0.37 9.4 8.2 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A UPF0242 PF06785.11 ETS61908.1 - 2.5 8.2 16.1 0.36 10.9 12.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Snapin_Pallidin PF14712.6 ETS61908.1 - 4.8 7.7 12.9 0.33 11.4 5.0 2.9 2 2 2 4 4 4 0 Snapin/Pallidin DUF2968 PF11180.8 ETS61908.1 - 5.2 6.7 18.8 0.4 10.3 13.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2968) VIT1 PF01988.19 ETS61908.1 - 5.5 6.8 6.0 2.9 7.7 4.2 1.6 1 1 0 1 1 1 0 VIT family Pkinase PF00069.25 ETS61909.1 - 4.1e-60 203.4 0.0 2.9e-59 200.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS61909.1 - 2.6e-27 95.7 0.0 6.9e-19 68.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS61909.1 - 2.9e-06 26.8 0.0 0.0036 16.7 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ETS61909.1 - 0.0023 17.0 0.0 0.0036 16.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETS61909.1 - 0.0025 17.8 0.1 0.037 14.0 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETS61909.1 - 0.0063 15.9 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ETS61909.1 - 0.092 11.8 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 ETS61909.1 - 0.14 11.7 0.0 0.29 10.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family zf-4CXXC_R1 PF10497.9 ETS61910.1 - 4.3e-15 55.8 12.1 8.4e-15 54.8 12.1 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 TF_Zn_Ribbon PF08271.12 ETS61910.1 - 0.033 13.7 4.5 0.1 12.1 4.5 1.9 1 0 0 1 1 1 0 TFIIB zinc-binding AT_hook PF02178.19 ETS61910.1 - 0.99 9.5 19.3 3.9 7.7 5.2 3.2 2 0 0 2 2 2 0 AT hook motif Sporozoite_P67 PF05642.11 ETS61910.1 - 1.7 6.6 13.6 0.77 7.8 5.4 2.4 2 0 0 2 2 2 0 Sporozoite P67 surface antigen MAPEG PF01124.18 ETS61911.1 - 2.2e-27 95.5 3.0 2.5e-27 95.3 3.0 1.0 1 0 0 1 1 1 1 MAPEG family Ferrochelatase PF00762.19 ETS61912.1 - 2.4e-106 355.4 0.0 3e-106 355.1 0.0 1.1 1 0 0 1 1 1 1 Ferrochelatase Synaptobrevin PF00957.21 ETS61912.1 - 1.5e-29 101.6 2.4 2.6e-29 100.8 2.4 1.3 1 0 0 1 1 1 1 Synaptobrevin CbiX PF01903.17 ETS61912.1 - 0.00058 20.2 0.1 1.7 9.0 0.0 2.5 2 0 0 2 2 2 2 CbiX ORF_12_N PF18042.1 ETS61912.1 - 0.12 12.8 1.0 9.5 6.7 0.1 2.5 2 0 0 2 2 2 0 ORF 12 gene product N-terminal UQ_con PF00179.26 ETS61913.1 - 3e-27 95.0 0.0 3.6e-27 94.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ETS61913.1 - 0.0062 16.4 0.0 0.0086 15.9 0.0 1.2 1 0 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 ETS61913.1 - 0.013 15.2 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B UFC1 PF08694.11 ETS61913.1 - 0.078 12.6 0.0 0.12 12.0 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 HECT PF00632.25 ETS61914.1 - 1.9e-98 329.7 0.0 2.5e-98 329.4 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Fructosamin_kin PF03881.14 ETS61915.1 - 4.1e-44 150.9 0.4 1.1e-22 80.5 1.2 2.1 1 1 1 2 2 2 2 Fructosamine kinase APH PF01636.23 ETS61915.1 - 3.2e-06 27.3 0.6 3.2e-06 27.3 0.6 1.5 2 0 0 2 2 2 1 Phosphotransferase enzyme family FH2 PF02181.23 ETS61916.1 - 0.2 10.7 16.1 0.95 8.5 5.8 2.3 1 1 0 2 2 2 0 Formin Homology 2 Domain KASH_CCD PF14662.6 ETS61916.1 - 0.41 10.4 24.4 0.66 9.8 24.4 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Spc7 PF08317.11 ETS61916.1 - 0.6 8.9 23.8 1 8.1 23.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF3584 PF12128.8 ETS61916.1 - 0.64 7.5 27.6 0.94 6.9 27.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Golgin_A5 PF09787.9 ETS61916.1 - 4.4 6.7 29.5 3.4 7.1 18.4 2.3 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF4200 PF13863.6 ETS61916.1 - 7.7 6.9 30.0 2.6 8.5 19.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Bromodomain PF00439.25 ETS61917.1 - 2.3e-31 107.7 0.2 2.9e-15 56.1 0.0 3.4 2 1 0 2 2 2 2 Bromodomain BET PF17035.5 ETS61917.1 - 2.6e-21 75.6 2.5 6.2e-21 74.3 2.5 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Abhydro_lipase PF04083.16 ETS61918.1 - 5.8e-15 54.6 0.0 9.6e-15 53.9 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ETS61918.1 - 2.6e-07 30.6 0.1 4.3e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS61918.1 - 0.0068 15.7 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Rgp1 PF08737.10 ETS61919.1 - 1.3e-106 357.2 0.0 2.1e-106 356.6 0.0 1.3 1 0 0 1 1 1 1 Rgp1 Arrestin_C PF02752.22 ETS61919.1 - 5.7e-07 30.1 0.0 0.00064 20.2 0.0 2.9 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETS61919.1 - 0.00098 19.2 0.0 0.065 13.3 0.0 2.5 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Spo0M PF07070.11 ETS61919.1 - 0.022 14.3 0.1 7.5 6.0 0.0 2.3 2 0 0 2 2 2 0 SpoOM protein Cupin_2 PF07883.11 ETS61921.1 - 2.8e-05 23.7 0.1 6e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Cupin domain Lyx_isomer PF07385.12 ETS61921.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 D-lyxose isomerase FMO-like PF00743.19 ETS61922.1 - 1.1e-43 149.5 0.0 3.9e-43 147.7 0.0 1.7 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETS61922.1 - 1.1e-20 74.1 0.0 2.8e-16 59.6 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS61922.1 - 4.9e-19 68.7 0.0 6.2e-15 55.2 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS61922.1 - 1.4e-10 41.3 0.6 5.6e-06 26.2 0.3 3.6 2 2 2 4 4 4 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS61922.1 - 1.8e-09 37.7 0.0 4.2e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ETS61922.1 - 5.6e-09 36.2 0.1 6.5e-05 23.0 0.0 3.4 2 1 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 ETS61922.1 - 1.3e-08 35.3 0.3 0.00056 20.4 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETS61922.1 - 7.7e-07 28.6 0.0 1e-05 24.9 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Amino_oxidase PF01593.24 ETS61922.1 - 1e-06 28.3 0.0 0.0034 16.7 0.0 2.9 2 1 1 3 3 3 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 ETS61922.1 - 7.3e-06 24.9 0.0 0.022 13.5 0.2 2.8 3 0 0 3 3 3 2 HI0933-like protein Lycopene_cycl PF05834.12 ETS61922.1 - 0.00074 18.7 0.1 0.12 11.4 0.0 2.7 3 0 0 3 3 3 1 Lycopene cyclase protein GIDA PF01134.22 ETS61922.1 - 0.001 18.2 0.5 0.85 8.6 0.0 3.1 4 0 0 4 4 4 2 Glucose inhibited division protein A Shikimate_DH PF01488.20 ETS61922.1 - 0.0022 18.1 0.0 0.27 11.3 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 ETS61922.1 - 0.0026 17.0 0.0 0.0072 15.6 0.0 1.7 2 0 0 2 2 2 1 Thi4 family NAD_binding_7 PF13241.6 ETS61922.1 - 0.0049 17.3 0.0 3.7 8.0 0.0 2.6 3 0 0 3 3 2 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 ETS61922.1 - 0.032 13.3 0.2 0.18 10.8 0.1 2.1 2 1 0 3 3 3 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 ETS61922.1 - 0.046 13.3 0.2 0.097 12.2 0.1 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 ETS61922.1 - 0.14 11.5 0.3 0.31 10.3 0.3 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 3HCDH_N PF02737.18 ETS61922.1 - 0.15 11.9 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 ETS61922.1 - 0.16 11.2 0.0 0.32 10.2 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 ETS61922.1 - 0.16 12.2 0.1 1 9.6 0.0 2.2 2 0 0 2 2 2 0 TrkA-N domain FF PF01846.19 ETS61923.1 - 2e-29 101.5 7.1 3.8e-07 30.2 0.1 6.8 5 2 0 5 5 5 5 FF domain WW PF00397.26 ETS61923.1 - 3.1e-09 36.8 7.9 3.3e-08 33.5 0.7 2.6 2 0 0 2 2 2 2 WW domain BUD22 PF09073.10 ETS61923.1 - 0.0051 16.2 25.4 0.0051 16.2 25.4 3.3 2 1 0 3 3 3 1 BUD22 DUF3752 PF12572.8 ETS61924.1 - 9.3e-14 52.2 54.3 1.6e-10 41.7 19.8 2.8 2 1 1 3 3 3 2 Protein of unknown function (DUF3752) TFIIA PF03153.13 ETS61924.1 - 1.9 8.4 21.1 2.7 7.9 21.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Polyketide_cyc2 PF10604.9 ETS61925.1 - 2e-11 44.3 0.0 2.7e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 ETS61925.1 - 0.053 13.7 0.0 0.072 13.3 0.0 1.3 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Acetate_kinase PF00871.17 ETS61926.1 - 4.6e-74 249.5 0.0 5.3e-74 249.3 0.0 1.0 1 0 0 1 1 1 1 Acetokinase family XFP_N PF09364.10 ETS61927.1 - 3.6e-124 414.3 0.0 7.6e-124 413.2 0.0 1.4 1 0 0 1 1 1 1 XFP N-terminal domain XFP_C PF09363.10 ETS61927.1 - 2.2e-68 229.7 0.0 3.5e-68 229.1 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain XFP PF03894.15 ETS61927.1 - 5.3e-66 221.7 0.0 1.5e-65 220.2 0.0 1.8 2 0 0 2 2 2 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase Pyr_redox_3 PF13738.6 ETS61927.1 - 1.8e-12 47.2 0.1 7.3e-12 45.1 0.1 2.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETS61927.1 - 6e-12 45.4 2.5 3.9e-09 36.1 2.5 3.2 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 ETS61927.1 - 5e-11 42.4 0.0 1.1e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS61927.1 - 5.7e-11 42.5 0.3 4.2e-10 39.7 0.0 2.5 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 ETS61927.1 - 4.3e-09 35.3 0.1 1e-08 34.1 0.1 1.5 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_9 PF13454.6 ETS61927.1 - 0.0001 22.3 0.2 0.11 12.5 0.0 3.3 3 0 0 3 3 3 1 FAD-NAD(P)-binding DAO PF01266.24 ETS61927.1 - 0.00034 20.3 0.6 0.0021 17.7 0.1 2.7 2 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETS61927.1 - 0.0022 17.3 0.2 0.0054 16.0 0.0 1.6 2 0 0 2 2 2 1 Thi4 family FAD_binding_2 PF00890.24 ETS61927.1 - 0.0043 16.2 0.0 0.22 10.6 0.0 2.5 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ETS61927.1 - 0.0055 16.1 2.3 0.014 14.8 0.0 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 ETS61927.1 - 0.0096 15.0 0.1 2.6 7.1 0.2 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Transket_pyr PF02779.24 ETS61927.1 - 0.08 12.6 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain MucBP_2 PF17965.1 ETS61928.1 - 0.057 14.0 0.1 0.24 12.0 0.1 2.1 1 0 0 1 1 1 0 Mucin binding domain Amidase PF01425.21 ETS61929.1 - 2.8e-84 283.7 0.0 1.2e-74 251.9 0.0 2.0 2 0 0 2 2 2 2 Amidase CCDC106 PF15794.5 ETS61929.1 - 0.011 15.5 0.2 0.019 14.7 0.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 NOC3p PF07540.11 ETS61931.1 - 1.4e-30 105.6 0.0 4.4e-30 104.0 0.0 1.9 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 ETS61931.1 - 1.1e-10 41.8 0.5 1.1e-10 41.8 0.5 2.9 4 0 0 4 4 4 1 CBF/Mak21 family DnaJ PF00226.31 ETS61932.1 - 1.5e-13 50.6 0.0 3.1e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain Nucleos_tra2_C PF07662.13 ETS61932.1 - 0.029 14.2 0.6 0.18 11.6 0.1 2.1 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter C-terminus 7tm_1 PF00001.21 ETS61933.1 - 1.7e-15 57.1 2.8 1.9e-15 56.9 2.5 1.3 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 ETS61933.1 - 9.7e-12 45.1 14.3 9.7e-12 45.1 14.3 1.8 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 ETS61933.1 - 0.001 19.1 0.1 0.001 19.1 0.1 2.5 3 1 1 4 4 4 1 G protein-coupled glucose receptor regulating Gpa2 C-term Ser_hydrolase PF06821.13 ETS61933.1 - 0.067 13.0 0.5 0.21 11.4 0.5 1.8 1 0 0 1 1 1 0 Serine hydrolase Microcin PF03526.13 ETS61933.1 - 0.39 10.6 1.4 4.1 7.3 0.1 2.4 2 0 0 2 2 2 0 Colicin E1 (microcin) immunity protein DUF308 PF03729.13 ETS61934.1 - 0.84 10.0 10.2 3.1 8.2 2.8 2.8 3 0 0 3 3 3 0 Short repeat of unknown function (DUF308) DUF3040 PF11239.8 ETS61934.1 - 2.8 8.3 7.6 1.4 9.3 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) Abhydrolase_1 PF00561.20 ETS61935.1 - 3.2e-36 125.3 0.0 4.3e-35 121.6 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold SMC_N PF02463.19 ETS61936.1 - 3.2e-19 69.2 0.0 7e-19 68.1 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETS61936.1 - 2.6e-16 60.7 37.8 1.1e-14 55.5 21.7 4.6 3 1 0 3 3 3 1 AAA domain AAA_21 PF13304.6 ETS61936.1 - 2.7e-06 27.4 0.0 0.03 14.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ETS61936.1 - 1.2e-05 25.2 0.9 1.2e-05 25.2 0.9 2.5 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ETS61936.1 - 0.0014 18.3 0.0 0.0031 17.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain IstB_IS21 PF01695.17 ETS61936.1 - 0.038 13.7 1.1 0.13 12.0 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Homeobox_KN PF05920.11 ETS61936.1 - 0.16 11.9 0.9 8 6.5 0.0 3.4 3 0 0 3 3 3 0 Homeobox KN domain PTCB-BRCT PF12738.7 ETS61936.1 - 0.19 11.7 0.1 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 twin BRCT domain Seadorna_VP6 PF07407.11 ETS61936.1 - 9.4 5.1 6.4 17 4.2 6.4 1.4 1 0 0 1 1 1 0 Seadornavirus VP6 protein Glyco_hydro_10 PF00331.20 ETS61937.1 - 3.8e-100 335.1 0.0 4.4e-100 334.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 MaoC_dehydratas PF01575.19 ETS61938.1 - 5.1e-09 35.7 0.0 1.5e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 MaoC like domain p450 PF00067.22 ETS61939.1 - 2.8e-62 211.0 0.0 4.1e-62 210.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 F-box-like PF12937.7 ETS61939.1 - 6.3e-05 22.8 2.7 7e-05 22.6 1.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ETS61939.1 - 0.0056 16.5 0.2 0.017 15.0 0.2 1.9 1 0 0 1 1 1 1 F-box domain LIP PF03583.14 ETS61940.1 - 1.7e-51 175.2 0.0 2.5e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 ETS61940.1 - 0.099 12.1 0.1 5.9 6.3 0.0 2.5 2 1 1 3 3 3 0 Prolyl oligopeptidase family Fungal_trans_2 PF11951.8 ETS61941.1 - 8.1e-10 38.1 0.9 2.2e-09 36.6 0.1 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61941.1 - 1.7e-07 31.3 9.3 4e-07 30.0 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Beta-lactamase PF00144.24 ETS61943.1 - 3.8e-43 148.0 0.0 5.5e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ETS61943.1 - 0.043 13.2 0.0 0.09 12.2 0.0 1.4 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 ETS61943.1 - 0.044 13.4 0.0 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Beta-lactamase enzyme family peroxidase PF00141.23 ETS61944.1 - 4.3e-83 278.5 0.0 3.5e-43 148.0 0.0 2.2 2 0 0 2 2 2 2 Peroxidase AA_permease_2 PF13520.6 ETS61945.1 - 1.3e-45 156.0 47.3 1.6e-45 155.7 47.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS61945.1 - 1.1e-15 57.3 39.6 1.1e-15 57.3 39.6 2.0 2 0 0 2 2 2 2 Amino acid permease Cu_amine_oxid PF01179.20 ETS61946.1 - 1.1e-155 518.6 0.0 1.4e-155 518.2 0.0 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 ETS61946.1 - 4.8e-07 29.9 0.1 1.1e-06 28.8 0.1 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cu_amine_oxidN3 PF02728.16 ETS61946.1 - 0.054 13.9 0.0 0.19 12.2 0.0 1.9 1 0 0 1 1 1 0 Copper amine oxidase, N3 domain Fungal_trans PF04082.18 ETS61947.1 - 3.2e-16 59.2 0.1 9.6e-16 57.6 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ETS61947.1 - 1.3e-07 31.6 15.3 6.2e-05 23.2 1.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Zn_clus PF00172.18 ETS61947.1 - 1.2e-06 28.5 8.9 1.2e-06 28.5 8.9 2.0 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2_4 PF13894.6 ETS61947.1 - 1.1e-05 25.8 12.4 0.02 15.7 0.8 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETS61947.1 - 0.00023 21.3 3.8 0.18 12.1 1.9 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETS61947.1 - 0.0071 16.7 3.1 1.3 9.5 1.5 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ETS61947.1 - 0.013 15.5 8.8 0.34 11.0 3.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger CENP-B_dimeris PF09026.10 ETS61947.1 - 0.18 12.2 9.6 0.099 13.0 6.7 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-H2C2_2 PF13465.6 ETS61947.1 - 0.59 10.7 12.8 0.35 11.4 0.9 3.3 3 0 0 3 3 3 0 Zinc-finger double domain PBP1_TM PF14812.6 ETS61947.1 - 1.1 9.6 5.9 2.8 8.4 5.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aldedh PF00171.22 ETS61948.1 - 4.7e-145 483.6 0.0 5.3e-145 483.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETS61948.1 - 0.00013 21.2 0.0 0.0042 16.2 0.0 2.2 2 0 0 2 2 2 2 Acyl-CoA reductase (LuxC) Aldedh PF00171.22 ETS61949.1 - 3.4e-06 25.8 0.1 7.2e-06 24.8 0.2 1.4 2 0 0 2 2 2 1 Aldehyde dehydrogenase family LigB PF02900.18 ETS61950.1 - 1.7e-17 63.4 0.0 2.1e-17 63.1 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Creatininase PF02633.14 ETS61950.1 - 0.068 12.6 0.0 0.16 11.4 0.0 1.6 2 0 0 2 2 2 0 Creatinine amidohydrolase Peptidase_S15 PF02129.18 ETS61952.1 - 3.7e-37 128.4 0.6 5.8e-37 127.7 0.6 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 ETS61952.1 - 8.3e-29 101.1 0.1 1.2e-28 100.6 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain FAD_binding_3 PF01494.19 ETS61953.1 - 4e-13 49.4 0.1 2.8e-12 46.5 0.1 2.0 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ETS61953.1 - 5.7e-05 23.3 0.0 0.00012 22.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETS61953.1 - 0.00038 19.8 0.7 0.0049 16.1 0.5 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS61953.1 - 0.00048 19.8 0.0 0.00082 19.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ETS61953.1 - 0.049 13.6 0.1 1 9.3 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 ETS61953.1 - 0.055 12.8 0.2 0.087 12.1 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 ETS61953.1 - 0.07 12.2 0.1 0.14 11.2 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 ETS61953.1 - 0.12 12.9 0.2 0.62 10.7 0.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETS61953.1 - 0.18 10.6 0.3 6.1 5.6 0.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase Glyco_hydro_1 PF00232.18 ETS61954.1 - 1e-103 347.2 0.0 1.6e-103 346.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Cellulase PF00150.18 ETS61954.1 - 0.015 14.7 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) FAA_hydrolase PF01557.18 ETS61955.1 - 6.9e-45 153.4 0.0 8.9e-45 153.0 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 ETS61955.1 - 1.9e-23 82.7 0.1 3.3e-23 81.9 0.1 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal DUF346 PF03984.13 ETS61955.1 - 0.039 13.7 0.3 0.1 12.4 0.3 1.7 1 0 0 1 1 1 0 Repeat of unknown function (DUF346) MFS_1 PF07690.16 ETS61956.1 - 1.2e-25 90.3 30.1 2e-13 50.0 7.3 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61956.1 - 8.5e-05 21.6 8.7 0.0075 15.2 1.3 2.7 3 1 0 3 3 3 2 Sugar (and other) transporter Claudin_3 PF06653.11 ETS61956.1 - 0.071 13.0 2.9 0.54 10.2 0.1 2.4 2 0 0 2 2 2 0 Tight junction protein, Claudin-like Fungal_trans PF04082.18 ETS61957.1 - 4.8e-08 32.4 0.0 7.9e-08 31.6 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS61957.1 - 0.0027 17.8 6.7 0.0099 16.0 6.7 1.9 1 1 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain KAR9 PF08580.10 ETS61957.1 - 8.5 4.8 6.2 14 4.1 6.2 1.2 1 0 0 1 1 1 0 Yeast cortical protein KAR9 FA_hydroxylase PF04116.13 ETS61958.1 - 3.5e-22 79.2 6.1 3.5e-22 79.2 6.1 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily UDPGT PF00201.18 ETS61959.1 - 0.053 12.3 0.0 0.15 10.9 0.0 1.6 2 0 0 2 2 2 0 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_trans_1_4 PF13692.6 ETS61959.1 - 0.072 13.5 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_28 PF03033.20 ETS61959.1 - 0.085 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Tri3 PF07428.11 ETS61960.1 - 0.036 13.0 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 15-O-acetyltransferase Tri3 Tri3 PF07428.11 ETS61961.1 - 1.1e-07 31.1 0.4 3.2e-07 29.6 0.4 1.6 1 1 0 1 1 1 1 15-O-acetyltransferase Tri3 AATase PF07247.12 ETS61961.1 - 0.082 11.4 0.0 0.13 10.8 0.0 1.2 1 0 0 1 1 1 0 Alcohol acetyltransferase MFS_1 PF07690.16 ETS61962.1 - 1e-35 123.3 51.3 1e-35 123.3 51.3 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS61962.1 - 5.5e-13 48.6 9.6 5.5e-13 48.6 9.6 3.1 2 1 0 3 3 3 2 Sugar (and other) transporter TRI12 PF06609.13 ETS61962.1 - 1.1e-07 30.7 20.3 1.5e-07 30.3 20.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HEAT_2 PF13646.6 ETS61965.1 - 0.00078 19.8 16.2 0.035 14.5 0.6 5.4 4 1 0 4 4 4 2 HEAT repeats TPR_19 PF14559.6 ETS61965.1 - 0.24 11.9 5.9 0.62 10.6 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Peroxidase_2 PF01328.17 ETS61966.1 - 6.5e-52 176.8 0.0 8.6e-52 176.4 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 ADC PF06314.11 ETS61967.1 - 4.7e-16 59.1 0.1 9.1e-16 58.1 0.1 1.4 2 0 0 2 2 2 1 Acetoacetate decarboxylase (ADC) Cupin_2 PF07883.11 ETS61967.1 - 0.00011 21.8 0.0 0.00026 20.7 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Zip PF02535.22 ETS61968.1 - 3.1e-38 131.9 24.4 3.1e-38 131.9 24.4 3.0 2 1 0 2 2 2 1 ZIP Zinc transporter HRXXH PF13933.6 ETS61969.1 - 1e-75 254.5 0.9 1e-75 254.5 0.9 1.4 2 0 0 2 2 2 1 Putative peptidase family Aspzincin_M35 PF14521.6 ETS61969.1 - 0.0029 18.2 0.8 0.0029 18.2 0.8 2.2 2 1 0 2 2 2 1 Lysine-specific metallo-endopeptidase NAD_binding_4 PF07993.12 ETS61970.1 - 1.5e-59 201.2 0.1 6.4e-56 189.4 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein adh_short PF00106.25 ETS61970.1 - 3.2e-49 167.0 2.4 5.4e-49 166.3 1.3 2.0 2 0 0 2 2 2 1 short chain dehydrogenase AMP-binding PF00501.28 ETS61970.1 - 8.4e-45 153.1 0.0 1.4e-35 122.8 0.0 2.2 1 1 1 2 2 2 2 AMP-binding enzyme adh_short_C2 PF13561.6 ETS61970.1 - 1.7e-37 129.2 0.9 2.6e-36 125.3 1.5 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS61970.1 - 3e-21 76.1 1.3 1.5e-17 64.1 1.1 2.4 2 0 0 2 2 2 2 KR domain Epimerase PF01370.21 ETS61970.1 - 1.1e-19 70.8 0.4 1.4e-10 41.1 0.0 3.3 2 2 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS61970.1 - 2e-10 40.2 0.0 5.5e-05 22.3 0.0 3.1 3 0 0 3 3 3 2 3-beta hydroxysteroid dehydrogenase/isomerase family PP-binding PF00550.25 ETS61970.1 - 6.7e-08 32.8 0.0 2.1e-07 31.2 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Polysacc_synt_2 PF02719.15 ETS61970.1 - 4.7e-07 29.2 2.0 3.1e-05 23.3 0.2 2.9 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ETS61970.1 - 1.9e-06 27.5 0.1 0.0018 17.7 0.1 2.3 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ETS61970.1 - 4.4e-05 23.5 4.7 0.0023 17.8 3.4 3.5 3 1 0 3 3 3 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ETS61970.1 - 5.1e-05 22.5 0.2 0.0058 15.8 0.0 2.9 2 1 0 2 2 2 1 RmlD substrate binding domain THF_DHG_CYH_C PF02882.19 ETS61970.1 - 0.0058 16.0 0.1 0.02 14.2 0.0 1.9 1 1 1 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain AMP-binding_C PF13193.6 ETS61970.1 - 0.0086 17.0 0.1 0.0086 17.0 0.1 2.8 4 0 0 4 4 1 1 AMP-binding enzyme C-terminal domain DFP PF04127.15 ETS61970.1 - 0.07 13.0 4.5 1.1 9.0 4.6 2.5 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Phage_C PF12025.8 ETS61970.1 - 0.11 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 Phage protein C NAD_binding_3 PF03447.16 ETS61970.1 - 6.4 7.5 6.5 47 4.7 0.1 3.6 3 1 0 3 3 3 0 Homoserine dehydrogenase, NAD binding domain TPR_14 PF13428.6 ETS61971.1 - 7.1e-07 29.5 10.1 0.0046 17.7 0.6 4.8 1 1 4 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETS61971.1 - 9e-06 26.2 3.0 0.099 13.3 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETS61971.1 - 4.3e-05 23.3 5.9 0.095 12.9 0.3 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS61971.1 - 0.00024 21.2 2.0 0.96 10.0 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS61971.1 - 0.0025 18.3 8.6 1.6 9.3 2.0 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETS61971.1 - 0.003 17.7 7.3 1.6 9.0 0.8 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS61971.1 - 0.036 14.3 2.4 0.13 12.5 2.4 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETS61971.1 - 0.81 10.1 3.3 9 6.8 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETS61971.1 - 8.2 7.3 5.9 50 4.8 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TIM PF00121.18 ETS61973.1 - 5.1e-55 186.5 0.0 6.1e-55 186.2 0.0 1.1 1 0 0 1 1 1 1 Triosephosphate isomerase LacAB_rpiB PF02502.18 ETS61974.1 - 1.7e-44 151.2 0.3 1.9e-44 151.0 0.3 1.0 1 0 0 1 1 1 1 Ribose/Galactose Isomerase DUF4514 PF14986.6 ETS61974.1 - 0.021 14.8 1.4 0.061 13.3 0.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4514) DUF836 PF05768.14 ETS61975.1 - 1.4e-11 44.7 0.0 1.6e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) AhpC-TSA PF00578.21 ETS61975.1 - 0.0033 17.4 0.0 0.0037 17.2 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family TPR_1 PF00515.28 ETS61977.1 - 3.7e-06 26.5 6.9 0.12 12.3 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETS61977.1 - 5.7e-06 26.7 15.2 0.00058 20.3 3.8 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETS61977.1 - 3.8e-05 23.5 8.2 0.045 13.9 0.4 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETS61977.1 - 0.00013 22.5 13.0 0.033 15.0 0.5 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS61977.1 - 0.016 15.4 7.1 0.4 10.9 4.4 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETS61977.1 - 0.046 14.4 2.1 0.046 14.4 2.1 3.8 1 1 4 5 5 5 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ETS61977.1 - 0.33 11.4 1.7 3.7 8.0 1.4 2.2 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation TPR_7 PF13176.6 ETS61977.1 - 0.38 10.9 4.3 3.3 8.0 0.2 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETS61977.1 - 1.1 9.7 10.4 1.4 9.3 2.4 2.9 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETS61977.1 - 2.3 9.1 6.3 31 5.5 0.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat NDUFA12 PF05071.16 ETS61978.1 - 1.8e-08 35.1 0.1 4.9e-08 33.7 0.1 1.7 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Cucumo_2B PF03263.13 ETS61978.1 - 0.18 12.3 4.8 0.084 13.3 0.7 2.1 2 0 0 2 2 2 0 Cucumovirus protein 2B DUF3365 PF11845.8 ETS61978.1 - 0.22 11.8 1.6 0.44 10.8 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) Menin PF05053.13 ETS61978.1 - 6.9 4.9 8.0 8.7 4.6 8.0 1.1 1 0 0 1 1 1 0 Menin Cse1 PF08506.10 ETS61979.1 - 1.4e-132 442.0 0.5 1.4e-130 435.5 0.6 2.2 2 0 0 2 2 2 2 Cse1 CAS_CSE1 PF03378.15 ETS61979.1 - 6.9e-121 403.8 0.0 1.2e-120 403.0 0.0 1.4 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 ETS61979.1 - 1.3e-12 47.4 0.7 5.3e-11 42.3 0.6 3.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 ETS61979.1 - 0.00034 20.7 1.5 0.0072 16.4 0.0 3.9 4 0 0 4 4 4 1 Exportin 1-like protein HEAT PF02985.22 ETS61979.1 - 0.064 13.5 2.2 9.2 6.8 0.2 4.4 4 0 0 4 4 4 0 HEAT repeat Nop PF01798.18 ETS61979.1 - 0.067 12.6 0.2 0.22 11.0 0.1 1.9 2 0 0 2 2 2 0 snoRNA binding domain, fibrillarin Rad51 PF08423.11 ETS61980.1 - 1.6e-21 76.7 0.7 3.4e-20 72.4 0.7 2.5 1 1 0 1 1 1 1 Rad51 RecA PF00154.21 ETS61980.1 - 7.8e-05 22.3 0.4 0.01 15.3 0.1 2.2 2 0 0 2 2 2 2 recA bacterial DNA recombination protein AAA_25 PF13481.6 ETS61980.1 - 0.00016 21.3 1.2 0.0006 19.5 1.2 2.0 1 1 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ETS61980.1 - 0.0061 15.9 0.0 0.0091 15.4 0.0 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 ETS61980.1 - 0.048 13.0 0.3 0.1 11.9 0.0 1.6 2 0 0 2 2 2 0 KaiC TarH PF02203.15 ETS61980.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue Amino_oxidase PF01593.24 ETS61981.1 - 9.7e-15 54.8 0.0 1.4e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS61981.1 - 1.7e-08 34.5 0.1 3.6e-08 33.5 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETS61981.1 - 0.0049 16.1 0.0 0.12 11.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS61981.1 - 0.015 14.9 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS61981.1 - 0.041 13.1 0.3 0.083 12.1 0.1 1.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS61981.1 - 0.053 13.5 0.1 0.33 10.9 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding TrkA_N PF02254.18 ETS61981.1 - 0.11 12.7 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 TrkA-N domain FAD_binding_3 PF01494.19 ETS61981.1 - 0.15 11.3 0.0 0.3 10.3 0.0 1.5 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 ETS61981.1 - 0.19 10.4 0.0 0.29 9.8 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Hexokinase_2 PF03727.16 ETS61982.1 - 6.2e-79 264.8 0.1 1.2e-78 263.9 0.0 1.5 2 0 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.21 ETS61982.1 - 1.2e-65 221.1 0.0 2.3e-65 220.2 0.0 1.5 1 0 0 1 1 1 1 Hexokinase YjgF_endoribonc PF14588.6 ETS61982.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 YjgF/chorismate_mutase-like, putative endoribonuclease Aldo_ket_red PF00248.21 ETS61983.1 - 1.3e-41 142.7 0.0 3.6e-40 138.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Cupin_8 PF13621.6 ETS61985.1 - 2.7e-28 99.4 0.0 4.7e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ETS61985.1 - 7.6e-05 22.3 0.2 0.00045 19.8 0.2 1.9 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_1 PF00190.22 ETS61985.1 - 0.056 13.1 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Cupin JmjC PF02373.22 ETS61985.1 - 0.13 12.7 0.0 0.36 11.3 0.0 1.6 1 1 0 1 1 1 0 JmjC domain, hydroxylase AA_permease PF00324.21 ETS61986.1 - 1.8e-133 445.6 37.2 2.1e-133 445.4 37.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS61986.1 - 1.6e-35 122.8 40.4 2e-35 122.4 40.4 1.1 1 0 0 1 1 1 1 Amino acid permease SID-1_RNA_chan PF13965.6 ETS61986.1 - 0.062 11.7 3.7 0.15 10.4 0.5 2.3 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 G-patch_2 PF12656.7 ETS61987.1 - 4.8e-23 81.0 2.3 1.6e-22 79.3 2.3 2.0 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 ETS61987.1 - 7.4e-05 22.6 7.1 0.00014 21.6 7.1 1.5 1 0 0 1 1 1 1 G-patch domain DUF747 PF05346.11 ETS61989.1 - 1.8e-118 395.6 3.4 2.4e-118 395.3 3.4 1.1 1 0 0 1 1 1 1 Eukaryotic membrane protein family N2227 PF07942.12 ETS61990.1 - 1e-94 316.7 0.0 1.3e-94 316.4 0.0 1.0 1 0 0 1 1 1 1 N2227-like protein Sod_Fe_C PF02777.18 ETS61991.1 - 2.5e-34 117.5 0.4 4.4e-34 116.7 0.1 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ETS61991.1 - 2.3e-31 108.1 3.4 2.3e-31 108.1 3.4 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain CAS_C PF12026.8 ETS61991.1 - 0.072 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain HAD PF12710.7 ETS61993.1 - 3.4e-21 76.5 0.0 4.5e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 ETS61993.1 - 2.3e-09 37.2 0.0 5.5e-09 35.9 0.0 1.6 1 1 1 2 2 2 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 ETS61993.1 - 0.0002 20.8 0.2 0.0012 18.2 0.1 1.9 2 0 0 2 2 2 1 Putative Phosphatase Hydrolase PF00702.26 ETS61993.1 - 0.00024 21.4 0.8 0.0099 16.2 0.0 2.8 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase SpoU_sub_bind PF08032.12 ETS61993.1 - 0.13 12.6 0.1 1.5 9.2 0.0 2.6 3 0 0 3 3 3 0 RNA 2'-O ribose methyltransferase substrate binding RRM_1 PF00076.22 ETS61994.1 - 2.3e-57 190.7 0.0 1.9e-18 66.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS61994.1 - 6.7e-06 25.7 0.0 0.006 16.2 0.0 3.1 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETS61994.1 - 0.00014 21.9 0.0 1.5 8.9 0.0 3.2 3 0 0 3 3 3 2 RNA binding motif Limkain-b1 PF11608.8 ETS61994.1 - 0.0021 18.1 0.1 7.2 6.8 0.0 3.6 3 1 0 3 3 3 1 Limkain b1 RRM_occluded PF16842.5 ETS61994.1 - 0.0058 16.5 0.0 16 5.5 0.0 3.1 3 0 0 3 3 3 1 Occluded RNA-recognition motif ATP-grasp_2 PF08442.10 ETS61994.1 - 0.011 15.3 0.0 15 5.1 0.0 3.2 3 0 0 3 3 3 0 ATP-grasp domain RRM_Rrp7 PF17799.1 ETS61994.1 - 0.04 13.7 0.0 10 5.9 0.0 2.7 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain Metallophos PF00149.28 ETS61995.1 - 2.1e-39 136.2 0.1 2.7e-39 135.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETS61995.1 - 1.2e-20 73.7 0.3 2.6e-20 72.6 0.1 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain WD40 PF00400.32 ETS61996.1 - 3.2e-35 119.6 25.6 7.5e-09 36.1 0.1 7.4 7 1 0 7 7 7 5 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 ETS61996.1 - 2.6e-27 95.6 0.0 5.5e-27 94.6 0.0 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 ETS61996.1 - 1.4e-09 38.1 0.0 0.0093 16.2 0.0 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS61996.1 - 0.0012 17.9 0.1 3.2 6.6 0.0 4.1 3 1 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WES_acyltransf PF03007.16 ETS61997.1 - 3e-15 56.7 0.1 7.7e-15 55.4 0.0 1.8 2 0 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.13 ETS61997.1 - 3.9e-11 43.1 0.0 1.7e-10 41.1 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1298) Mon2_C PF16206.5 ETS61999.1 - 0.073 11.2 0.0 0.18 9.9 0.0 1.5 2 0 0 2 2 2 0 C-terminal region of Mon2 protein 5_nucleotid_C PF02872.18 ETS61999.1 - 0.1 12.8 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 5'-nucleotidase, C-terminal domain ATP-synt_E PF05680.12 ETS62000.1 - 1.4e-20 73.4 0.2 1.5e-20 73.3 0.2 1.0 1 0 0 1 1 1 1 ATP synthase E chain NAC PF01849.18 ETS62001.1 - 1e-21 76.6 0.0 1.8e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 NAC domain DMRL_synthase PF00885.19 ETS62002.1 - 2.3e-49 166.8 0.0 3.5e-49 166.3 0.0 1.2 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase GST_N PF02798.20 ETS62002.1 - 1e-10 41.8 0.0 2.7e-10 40.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ETS62002.1 - 9.2e-10 38.6 0.0 2e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ETS62002.1 - 9e-09 35.6 0.1 1.9e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETS62002.1 - 1.7e-08 34.6 0.0 2.9e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETS62002.1 - 4.1e-05 23.5 0.0 8.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ETS62002.1 - 0.028 14.7 0.0 0.056 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain ECH_2 PF16113.5 ETS62004.1 - 2.2e-88 297.0 1.1 9e-65 219.4 0.0 2.9 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ETS62004.1 - 1.6e-21 76.8 3.6 1.6e-11 44.0 0.2 2.7 2 1 0 3 3 3 2 Enoyl-CoA hydratase/isomerase FAM199X PF15814.5 ETS62004.1 - 0.49 9.4 2.7 1.1 8.3 2.7 1.5 1 0 0 1 1 1 0 Protein family FAM199X Zn_clus PF00172.18 ETS62005.1 - 3.4 7.9 7.8 7.4 6.8 0.9 2.1 1 1 1 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF3435 PF11917.8 ETS62007.1 - 0.0046 16.0 0.0 0.26 10.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3435) Clp1 PF06807.14 ETS62008.1 - 1.7e-29 102.6 0.0 3.9e-29 101.4 0.0 1.6 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 ETS62008.1 - 7.1e-24 84.6 0.0 5.6e-18 65.4 0.0 3.9 2 1 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 ETS62008.1 - 7.7e-23 80.5 0.0 1.3e-22 79.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor AAA_16 PF13191.6 ETS62008.1 - 0.01 16.3 0.0 0.077 13.4 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 ETS62008.1 - 0.054 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETS62008.1 - 0.073 13.2 0.1 5.3 7.2 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AMP-binding PF00501.28 ETS62009.1 - 2.3e-93 313.1 0.0 2.9e-93 312.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS62009.1 - 4.8e-28 98.0 2.1 1.2e-26 93.4 0.1 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ETS62009.1 - 5e-16 58.3 0.3 1.3e-15 57.0 0.3 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus ADH_zinc_N PF00107.26 ETS62010.1 - 9.2e-25 87.1 0.0 1.1e-22 80.4 0.0 2.2 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS62010.1 - 1.5e-16 61.7 0.0 3.3e-16 60.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS62010.1 - 1.1e-10 41.3 0.2 3e-10 39.9 0.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short PF00106.25 ETS62010.1 - 0.0015 18.0 0.5 0.0024 17.3 0.5 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Peripla_BP_6 PF13458.6 ETS62010.1 - 0.014 15.1 0.2 0.034 13.8 0.0 1.7 2 0 0 2 2 2 0 Periplasmic binding protein Biotin_carb_N PF00289.22 ETS62010.1 - 0.06 13.9 0.6 0.55 10.8 0.1 2.5 3 0 0 3 3 3 0 Biotin carboxylase, N-terminal domain IF4E PF01652.18 ETS62011.1 - 2.2e-44 151.0 0.0 3.3e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E tRNA_U5-meth_tr PF05958.11 ETS62014.1 - 1.1e-23 83.8 0.0 3e-22 79.1 0.0 2.5 2 1 0 2 2 2 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 ETS62014.1 - 3.8e-10 39.7 0.0 7.6e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS62014.1 - 1.4e-06 28.9 0.0 4.3e-06 27.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ETS62014.1 - 3.3e-06 26.8 0.0 6.1e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 ETS62014.1 - 0.00041 20.9 0.0 0.0013 19.4 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS62014.1 - 0.00047 19.8 0.1 0.0011 18.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain PrmA PF06325.13 ETS62014.1 - 0.0011 18.5 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 ETS62014.1 - 0.0073 16.1 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_4 PF02390.17 ETS62014.1 - 0.013 15.0 0.0 0.026 14.0 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Ubie_methyltran PF01209.18 ETS62014.1 - 0.074 12.4 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TPMT PF05724.11 ETS62014.1 - 0.076 12.7 0.0 0.22 11.1 0.0 1.8 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) SMYLE_N PF18615.1 ETS62014.1 - 0.27 10.8 3.2 0.47 10.0 3.2 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Hamartin PF04388.12 ETS62014.1 - 0.56 8.8 5.6 0.96 8.0 5.6 1.3 1 0 0 1 1 1 0 Hamartin protein DUF2058 PF09831.9 ETS62015.1 - 0.091 12.9 4.1 0.15 12.3 4.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) SKN1 PF03935.15 ETS62016.1 - 7.8e-189 628.2 1.7 9.2e-189 628.0 1.7 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Glyco_hydro_16 PF00722.21 ETS62016.1 - 0.0014 18.2 3.9 0.46 9.9 0.0 2.8 3 0 0 3 3 3 2 Glycosyl hydrolases family 16 Zn_clus PF00172.18 ETS62017.1 - 1.6e-08 34.5 11.9 2.8e-08 33.8 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Diphthamide_syn PF01866.17 ETS62018.1 - 3.4e-89 299.3 0.0 1e-50 172.9 0.0 3.5 2 1 0 2 2 2 2 Putative diphthamide synthesis protein ANAPC4_WD40 PF12894.7 ETS62019.1 - 2.9e-05 24.3 0.1 0.0081 16.4 0.0 3.3 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ETS62019.1 - 3.3e-05 24.2 2.3 14 6.3 0.1 4.4 4 0 0 4 4 4 2 PQQ-like domain PQQ_2 PF13360.6 ETS62019.1 - 5.4e-05 22.9 1.1 0.018 14.6 0.1 2.4 2 1 0 2 2 2 2 PQQ-like domain WD40 PF00400.32 ETS62019.1 - 0.0006 20.6 10.5 0.13 13.1 0.1 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat Cwf_Cwc_15 PF04889.12 ETS62019.1 - 2.7 7.7 23.1 0.57 9.9 0.7 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein MWFE PF15879.5 ETS62020.1 - 2.9e-22 78.6 0.5 3.5e-22 78.3 0.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit DUF2370 PF10176.9 ETS62021.1 - 5.3e-75 252.0 0.0 2.1e-74 250.0 0.0 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2370) TMEM252 PF15664.5 ETS62021.1 - 0.62 9.8 0.0 0.62 9.8 0.0 2.6 4 0 0 4 4 4 0 Transmembrane protein 252 family SPX PF03105.19 ETS62021.1 - 1.5 8.7 6.2 40 4.0 6.1 2.3 2 0 0 2 2 2 0 SPX domain ABC_membrane PF00664.23 ETS62022.1 - 8.3e-44 150.3 21.8 5.6e-27 95.1 8.6 2.7 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS62022.1 - 3.2e-37 128.1 0.0 1.7e-21 77.1 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ETS62022.1 - 1.2e-10 41.2 0.0 0.00065 19.2 0.0 3.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS62022.1 - 0.00019 21.1 2.8 0.021 14.6 0.2 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ETS62022.1 - 0.00044 20.1 0.5 0.12 12.1 0.1 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 ETS62022.1 - 0.0011 18.1 0.1 0.056 12.5 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 ETS62022.1 - 0.0011 19.3 0.3 2.3 8.5 0.0 3.1 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 ETS62022.1 - 0.0088 16.2 0.2 0.0088 16.2 0.2 1.8 2 0 0 2 2 1 1 Helicase HerA, central domain MeaB PF03308.16 ETS62022.1 - 0.011 14.7 0.0 0.021 13.8 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 ETS62022.1 - 0.018 15.5 0.8 0.52 10.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETS62022.1 - 0.019 15.3 6.8 0.073 13.5 0.3 3.9 4 1 0 4 4 3 0 AAA ATPase domain MMR_HSR1 PF01926.23 ETS62022.1 - 0.025 14.7 1.2 0.054 13.6 0.1 2.1 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_7 PF12775.7 ETS62022.1 - 0.036 13.6 0.1 3.9 6.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETS62022.1 - 0.042 13.7 0.6 4.6 7.1 0.0 2.5 2 0 0 2 2 2 0 RsgA GTPase TrwB_AAD_bind PF10412.9 ETS62022.1 - 0.047 12.6 0.4 0.52 9.2 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain SbcCD_C PF13558.6 ETS62022.1 - 0.048 13.9 0.2 6.4 7.1 0.1 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 ETS62022.1 - 0.057 13.6 0.4 5.8 7.1 0.1 2.8 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ETS62022.1 - 0.062 12.9 2.5 6.7 6.3 0.9 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 ETS62022.1 - 0.067 12.8 2.1 4.1 6.9 0.0 2.9 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ETS62022.1 - 0.07 12.5 2.5 0.77 9.1 0.4 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family NACHT PF05729.12 ETS62022.1 - 0.11 12.4 0.1 13 5.6 0.0 2.6 2 0 0 2 2 2 0 NACHT domain ATP_bind_1 PF03029.17 ETS62022.1 - 0.14 11.9 0.6 0.6 9.8 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 ETS62022.1 - 0.21 11.6 1.9 17 5.4 0.3 2.6 2 0 0 2 2 2 0 Dynamin family Pox_A32 PF04665.12 ETS62022.1 - 0.28 10.6 2.5 13 5.1 0.3 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_18 PF13238.6 ETS62022.1 - 0.61 10.6 2.9 3.1 8.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain Aa_trans PF01490.18 ETS62024.1 - 8.9e-31 107.0 30.2 1.2e-30 106.6 30.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MMPL PF03176.15 ETS62024.1 - 0.04 12.8 6.0 0.12 11.3 3.7 2.2 2 0 0 2 2 2 0 MMPL family Aim19 PF10315.9 ETS62026.1 - 5.1e-17 62.2 4.5 4.3e-16 59.2 4.5 2.1 1 1 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Chitin_synth_2 PF03142.15 ETS62027.1 - 1.4e-227 756.5 0.1 2.1e-227 756.0 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Cyt-b5 PF00173.28 ETS62027.1 - 5.3e-23 81.0 0.3 2.9e-16 59.3 0.0 2.9 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 ETS62027.1 - 1.3e-18 66.6 0.2 1e-15 57.4 0.1 3.1 3 0 0 3 3 3 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 ETS62027.1 - 3.4e-11 43.4 1.9 3.4e-11 43.4 1.9 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ETS62027.1 - 1.1e-10 41.8 0.1 1.9e-09 37.8 0.0 2.6 3 0 0 3 3 3 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ETS62027.1 - 5.9e-06 26.2 0.1 0.0083 16.0 0.0 2.8 3 0 0 3 3 3 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ETS62027.1 - 0.00021 20.8 0.0 0.00085 18.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 21 Jiv90 PF14901.6 ETS62027.1 - 0.0013 18.8 0.6 0.54 10.4 0.0 2.5 2 0 0 2 2 2 2 Cleavage inducing molecular chaperone DUF1622 PF07784.11 ETS62027.1 - 0.19 11.6 1.5 13 5.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1622) HSF_DNA-bind PF00447.17 ETS62028.1 - 2.3e-27 95.4 0.2 3.7e-27 94.8 0.2 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding GIT_CC PF16559.5 ETS62028.1 - 3.8 7.4 7.6 1.2 9.0 2.7 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor AA_permease_2 PF13520.6 ETS62029.1 - 5.3e-65 219.9 44.7 6.8e-65 219.6 44.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS62029.1 - 8.1e-19 67.6 38.9 1.1e-18 67.2 38.9 1.1 1 0 0 1 1 1 1 Amino acid permease Gram_pos_anchor PF00746.21 ETS62029.1 - 1.2 9.1 0.0 1.2 9.1 0.0 3.6 5 0 0 5 5 5 0 LPXTG cell wall anchor motif DUF1980 PF09323.10 ETS62029.1 - 9.9 6.0 7.0 35 4.3 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF1980) TFIIF_beta PF02270.15 ETS62030.1 - 2.4e-30 104.4 0.3 4e-30 103.8 0.3 1.3 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 ETS62030.1 - 3.5e-22 79.6 0.0 6.3e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus DUF3245 PF11595.8 ETS62030.1 - 4.5 7.7 13.2 2.5 8.6 0.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3245) Ribonuclease_3 PF00636.26 ETS62031.1 - 8.7e-08 32.7 0.0 2.4e-07 31.3 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 ETS62031.1 - 5.1e-07 30.3 0.0 1e-06 29.4 0.0 1.5 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonucleas_3_3 PF14622.6 ETS62031.1 - 6.9e-06 26.3 0.0 0.11 12.7 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease-III-like WD40 PF00400.32 ETS62032.1 - 5.2e-42 141.0 10.7 2.7e-09 37.5 0.1 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62032.1 - 2.1e-11 43.9 1.4 0.091 13.1 0.1 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS62032.1 - 4.5e-06 25.8 0.0 1.9 7.4 0.0 3.9 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETS62032.1 - 0.0002 20.2 6.0 0.3 9.7 0.0 4.4 3 2 0 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETS62032.1 - 0.0007 18.6 0.1 0.0007 18.6 0.1 1.8 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain VID27 PF08553.10 ETS62032.1 - 0.062 12.3 0.0 0.28 10.2 0.0 1.8 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Frtz PF11768.8 ETS62032.1 - 0.088 11.1 0.0 0.16 10.2 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETS62032.1 - 0.18 10.5 0.0 2.9 6.5 0.0 2.8 1 1 0 2 2 2 0 Nup133 N terminal like DUF4078 PF13300.6 ETS62033.1 - 2.8e-12 46.8 5.1 1.2e-11 44.7 5.1 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4078) CENP-H PF05837.12 ETS62033.1 - 0.59 10.6 4.3 1.6 9.2 0.1 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) HTH_9 PF08221.11 ETS62034.1 - 3.4e-16 59.1 0.9 1.1e-07 31.8 0.0 5.3 5 0 0 5 5 5 3 RNA polymerase III subunit RPC82 helix-turn-helix domain RNA_pol_Rpc82 PF05645.13 ETS62034.1 - 1.2e-15 58.0 0.2 1.8e-14 54.1 0.3 2.3 2 0 0 2 2 2 1 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 ETS62034.1 - 2.8e-05 23.9 0.3 9.6e-05 22.2 0.0 2.1 2 0 0 2 2 2 1 TFIIE alpha subunit HTH_24 PF13412.6 ETS62034.1 - 1.4 8.5 4.5 0.99 9.0 0.1 2.8 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding TruB_N PF01509.18 ETS62035.1 - 4e-38 131.1 0.0 2.9e-37 128.3 0.0 2.0 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ETS62035.1 - 0.00081 19.5 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Hydrolase_4 PF12146.8 ETS62036.1 - 7.6e-43 146.5 0.0 1.6e-42 145.4 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DcpS_C PF11969.8 ETS62036.1 - 4.7e-19 69.0 0.0 8.3e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Abhydrolase_6 PF12697.7 ETS62036.1 - 2.2e-09 38.2 0.0 4.9e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETS62036.1 - 2.7e-09 37.1 0.2 3.8e-07 30.0 0.0 2.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold HIT PF01230.23 ETS62036.1 - 4.6e-05 24.1 3.3 0.00059 20.5 3.3 2.2 1 1 0 1 1 1 1 HIT domain Abhydrolase_3 PF07859.13 ETS62036.1 - 0.00025 20.9 0.0 0.00051 20.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF900 PF05990.12 ETS62036.1 - 0.045 13.3 0.0 0.15 11.5 0.0 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 ETS62036.1 - 0.1 11.7 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase PGAP1 PF07819.13 ETS62036.1 - 0.2 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Methyltransf_11 PF08241.12 ETS62037.1 - 9.3e-21 74.3 0.0 1.7e-20 73.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS62037.1 - 1.2e-20 74.0 0.0 1.9e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS62037.1 - 2.1e-15 57.2 0.0 4.7e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS62037.1 - 4.9e-13 49.1 0.0 1.5e-12 47.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS62037.1 - 6.1e-13 49.4 0.0 1.7e-12 47.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ETS62037.1 - 8.5e-05 21.6 0.0 0.00017 20.7 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) PrmA PF06325.13 ETS62037.1 - 0.0001 21.8 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 ETS62037.1 - 0.00018 20.9 0.0 0.00057 19.3 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ETS62037.1 - 0.0042 16.7 0.0 0.014 14.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain NodS PF05401.11 ETS62037.1 - 0.0046 16.6 0.0 0.013 15.2 0.0 1.6 1 1 0 1 1 1 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 ETS62037.1 - 0.0053 16.1 0.0 0.0081 15.5 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 ETS62037.1 - 0.023 14.7 0.0 0.041 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Mpp10 PF04006.12 ETS62038.1 - 3.6e-111 372.5 111.3 1.7e-96 324.1 30.1 3.2 1 1 1 3 3 3 3 Mpp10 protein BUD22 PF09073.10 ETS62038.1 - 0.0019 17.6 29.7 0.0019 17.6 29.7 5.3 4 1 1 5 5 5 1 BUD22 DAAD PF18752.1 ETS62038.1 - 0.51 10.1 3.7 0.41 10.4 1.8 1.7 2 0 0 2 2 2 0 Dictyosteliid AID/APOBEC-like Deaminase DENN PF02141.21 ETS62039.1 - 1.1e-19 71.1 0.0 1.9e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain Methyltransf_16 PF10294.9 ETS62039.1 - 2.1e-10 40.6 0.0 4.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase FlxA PF14282.6 ETS62039.1 - 0.0083 16.1 14.6 0.33 11.0 6.2 2.7 2 0 0 2 2 2 2 FlxA-like protein Spc7 PF08317.11 ETS62039.1 - 0.12 11.2 15.4 0.013 14.4 8.7 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Cluap1 PF10234.9 ETS62039.1 - 0.74 9.2 13.2 0.2 11.1 7.5 2.1 2 0 0 2 2 2 0 Clusterin-associated protein-1 IFT57 PF10498.9 ETS62039.1 - 0.87 8.5 10.2 4.5 6.1 0.6 2.5 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Golgin_A5 PF09787.9 ETS62039.1 - 1.8 8.0 14.6 0.35 10.3 8.6 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 TMF_TATA_bd PF12325.8 ETS62039.1 - 4.5 7.5 22.1 0.045 14.0 8.1 3.5 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding OmpH PF03938.14 ETS62039.1 - 4.5 7.6 14.5 3.2 8.1 8.2 2.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3450 PF11932.8 ETS62039.1 - 8.6 5.6 14.5 11 5.3 8.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Sugar_tr PF00083.24 ETS62040.1 - 1.8e-89 300.7 22.0 2.3e-89 300.4 22.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS62040.1 - 1.2e-12 47.5 44.7 7e-10 38.4 17.3 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily ArfGap PF01412.18 ETS62041.1 - 2.5e-40 137.2 0.1 4.3e-40 136.4 0.1 1.4 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf baeRF_family8 PF18851.1 ETS62043.1 - 0.036 14.1 0.1 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 8 SUI1 PF01253.22 ETS62044.1 - 2.3e-13 50.4 0.0 4.5e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 TnpV PF14198.6 ETS62044.1 - 0.0022 18.0 0.1 0.0033 17.4 0.1 1.2 1 0 0 1 1 1 1 Transposon-encoded protein TnpV Cgr1 PF03879.14 ETS62044.1 - 0.076 13.4 9.5 0.15 12.5 9.5 1.4 1 0 0 1 1 1 0 Cgr1 family DUF1771 PF08590.10 ETS62045.1 - 3.6e-22 78.5 10.9 3.7e-22 78.4 6.6 2.9 3 0 0 3 3 3 1 Domain of unknown function (DUF1771) Smr PF01713.21 ETS62045.1 - 5.4e-12 45.9 0.4 1.4e-11 44.6 0.4 1.8 1 0 0 1 1 1 1 Smr domain Peripla_BP_2 PF01497.18 ETS62045.1 - 0.0033 17.0 0.2 0.0071 15.9 0.2 1.6 1 1 0 1 1 1 1 Periplasmic binding protein DUF4407 PF14362.6 ETS62045.1 - 0.37 10.1 4.2 0.54 9.6 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mon1 PF03164.14 ETS62046.1 - 3.1e-95 319.6 0.0 7.6e-90 301.9 0.0 2.9 2 1 0 2 2 2 2 Trafficking protein Mon1 Thiamine_BP PF01910.17 ETS62047.1 - 4.3e-23 81.0 0.0 5.3e-23 80.7 0.0 1.1 1 0 0 1 1 1 1 Thiamine-binding protein Ykof PF07615.11 ETS62047.1 - 0.093 13.2 0.0 0.12 12.8 0.0 1.2 1 0 0 1 1 1 0 YKOF-related Family PPR_3 PF13812.6 ETS62047.1 - 0.14 12.3 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Pentatricopeptide repeat domain MutS_V PF00488.21 ETS62048.1 - 3.5e-79 265.2 0.0 5.9e-79 264.5 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETS62048.1 - 5.2e-36 124.7 0.7 5.2e-36 124.7 0.7 2.5 3 0 0 3 3 3 1 MutS domain III MutS_II PF05188.17 ETS62048.1 - 2.6e-17 63.4 0.0 1.2e-16 61.2 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ETS62048.1 - 3.6e-15 56.1 3.2 4.8e-15 55.7 0.5 2.6 3 0 0 3 3 3 1 MutS family domain IV MutS_I PF01624.20 ETS62048.1 - 1.6e-12 47.6 0.0 3.1e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 MutS domain I zf-ZPR1 PF03367.13 ETS62048.1 - 0.18 11.6 0.1 2.1 8.2 0.0 2.8 3 1 1 4 4 4 0 ZPR1 zinc-finger domain LTV PF04180.14 ETS62048.1 - 0.28 10.9 3.4 1.8 8.2 0.2 2.2 2 0 0 2 2 2 0 Low temperature viability protein Ribonuclease_T2 PF00445.18 ETS62049.1 - 2.7e-25 89.7 0.0 4.3e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease T2 family MMR_HSR1_Xtn PF16897.5 ETS62050.1 - 4.7e-39 132.7 1.0 9.3e-39 131.7 0.7 1.7 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ETS62050.1 - 1.6e-21 76.1 0.0 2.9e-21 75.3 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ETS62050.1 - 8.4e-21 74.2 0.0 1.9e-20 73.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETS62050.1 - 5e-09 35.9 0.2 1.5e-08 34.3 0.0 1.9 2 1 1 3 3 3 1 Ferrous iron transport protein B MeaB PF03308.16 ETS62050.1 - 0.088 11.8 3.2 0.13 11.2 0.5 2.3 2 1 1 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ETS62050.1 - 0.12 12.4 2.2 1.3 9.0 0.0 2.6 2 1 1 3 3 3 0 Dynamin family FAD_binding_3 PF01494.19 ETS62051.1 - 1e-26 94.0 0.1 1.7e-26 93.3 0.1 1.3 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS62051.1 - 1.6e-11 44.0 0.6 1.2e-05 24.7 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS62051.1 - 7e-11 42.3 0.6 0.0002 21.0 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETS62051.1 - 1.2e-07 32.2 0.1 0.00081 19.9 0.1 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS62051.1 - 4.4e-06 26.8 0.2 1.3e-05 25.3 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 ETS62051.1 - 1.9e-05 23.7 0.7 0.0042 16.0 0.0 2.8 2 1 1 3 3 3 1 Tryptophan halogenase HI0933_like PF03486.14 ETS62051.1 - 0.00064 18.5 0.2 0.29 9.8 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_binding_2 PF00890.24 ETS62051.1 - 0.0028 16.8 1.2 0.063 12.4 0.2 2.3 2 0 0 2 2 2 1 FAD binding domain AlaDh_PNT_C PF01262.21 ETS62051.1 - 0.004 16.5 0.4 0.018 14.3 0.2 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain CoA_transf_3 PF02515.17 ETS62051.1 - 0.0042 16.3 0.1 0.0068 15.6 0.1 1.3 1 0 0 1 1 1 1 CoA-transferase family III GIDA PF01134.22 ETS62051.1 - 0.0067 15.6 0.3 0.018 14.1 0.3 1.7 1 1 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 ETS62051.1 - 0.0085 15.4 0.1 0.16 11.3 0.0 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase ApbA PF02558.16 ETS62051.1 - 0.037 13.7 0.2 0.068 12.8 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 ETS62051.1 - 0.11 12.3 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 ETS62051.1 - 0.14 11.2 0.0 14 4.6 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase Cyt-b5 PF00173.28 ETS62052.1 - 4.8e-10 39.4 0.2 5.4e-10 39.3 0.2 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PNP_phzG_C PF10590.9 ETS62053.1 - 5.5e-23 80.8 0.4 1.1e-22 79.8 0.4 1.5 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 ETS62053.1 - 2.5e-19 69.3 0.0 4.2e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 ETS62053.1 - 0.006 17.2 0.0 0.013 16.1 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase TctB PF07331.11 ETS62054.1 - 0.082 13.2 4.9 0.17 12.1 3.2 2.0 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF4064 PF13273.6 ETS62054.1 - 0.19 12.0 5.5 13 6.2 7.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) O-ag_pol_Wzy PF14296.6 ETS62054.1 - 10 4.7 10.7 2.9 6.5 0.1 2.9 3 0 0 3 3 3 0 O-antigen polysaccharide polymerase Wzy Amidohydro_3 PF07969.11 ETS62055.1 - 3.4e-71 241.2 0.1 4e-71 240.9 0.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ETS62055.1 - 3.3e-17 62.8 0.0 5.9e-13 48.8 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family SpoVS PF04232.12 ETS62055.1 - 0.032 13.9 0.4 0.089 12.5 0.4 1.7 1 0 0 1 1 1 0 Stage V sporulation protein S (SpoVS) EAP30 PF04157.16 ETS62058.1 - 1.3e-28 99.9 0.0 2e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 ETS62058.1 - 1.1e-24 86.4 0.0 1.9e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 zf-RanBP PF00641.18 ETS62058.1 - 0.0028 17.0 22.5 0.0039 16.5 1.5 3.4 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others DZR PF12773.7 ETS62058.1 - 0.044 13.8 11.4 2 8.5 0.6 3.2 3 0 0 3 3 3 0 Double zinc ribbon Nif11 PF07862.11 ETS62058.1 - 1.2 9.5 4.8 2.8 8.3 4.8 1.6 1 0 0 1 1 1 0 Nif11 domain Vps36-NZF-N PF16988.5 ETS62058.1 - 3.3 7.2 13.5 0.08 12.3 3.5 3.0 2 2 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CLU PF13236.6 ETS62059.1 - 3.6e-75 252.6 0.0 5.6e-75 252.0 0.0 1.3 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 ETS62059.1 - 4e-45 154.0 0.0 9.2e-45 152.8 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 ETS62059.1 - 2.6e-17 62.9 6.9 6.4e-08 32.8 1.3 3.8 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETS62059.1 - 2.6e-14 52.5 9.4 0.00091 19.0 0.2 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat CLU_N PF15044.6 ETS62059.1 - 3.6e-06 27.2 0.0 1.7e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term DUF727 PF05303.12 ETS62059.1 - 0.0039 17.2 0.0 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF727) DFRP_C PF16543.5 ETS62059.1 - 0.81 10.2 4.9 3.2 8.3 4.9 2.1 1 0 0 1 1 1 0 DRG Family Regulatory Proteins, Tma46 HMG-CoA_red PF00368.18 ETS62060.1 - 3.1e-144 480.5 5.1 5e-144 479.8 5.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 ETS62060.1 - 2.7e-16 59.8 1.7 6e-08 32.7 0.1 2.5 2 0 0 2 2 2 2 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ETS62060.1 - 4.5e-07 28.4 0.5 0.0016 16.6 0.0 2.3 2 0 0 2 2 2 2 Patched family HPIH PF13323.6 ETS62060.1 - 0.0018 18.2 0.6 0.0047 16.8 0.6 1.7 1 0 0 1 1 1 1 N-terminal domain with HPIH motif PITH PF06201.13 ETS62061.1 - 2.6e-33 115.4 0.0 3.3e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain C2 PF00168.30 ETS62062.1 - 5.1e-26 91.0 0.0 9.5e-16 58.0 0.0 2.5 2 0 0 2 2 2 2 C2 domain PI3K_1B_p101 PF10486.9 ETS62062.1 - 3.4 5.3 7.5 6.3 4.4 7.5 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Ribosomal_L38e PF01781.18 ETS62063.1 - 9e-33 112.2 1.5 1.4e-32 111.6 1.5 1.3 1 0 0 1 1 1 1 Ribosomal L38e protein family E6 PF00518.17 ETS62063.1 - 0.042 14.3 0.0 0.068 13.6 0.0 1.3 1 0 0 1 1 1 0 Early Protein (E6) Ribosomal_S11 PF00411.19 ETS62064.1 - 8.3e-08 32.6 0.1 8.3e-08 32.6 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein S11 EVE PF01878.18 ETS62065.1 - 7.3e-41 139.6 0.0 2.2e-40 138.0 0.0 1.7 1 1 0 1 1 1 1 EVE domain Mpv17_PMP22 PF04117.12 ETS62066.1 - 6.8e-22 77.5 0.2 1.1e-21 76.8 0.2 1.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family BCIP PF13862.6 ETS62068.1 - 2.7e-49 167.8 0.0 3.2e-49 167.5 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein Aldo_ket_red PF00248.21 ETS62069.1 - 8.6e-75 251.7 0.0 1e-74 251.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Clat_adaptor_s PF01217.20 ETS62070.1 - 1.2e-53 180.8 1.0 1.2e-53 180.8 1.0 1.6 2 0 0 2 2 2 1 Clathrin adaptor complex small chain SCP2 PF02036.17 ETS62070.1 - 3.5e-24 85.2 4.0 3.9e-24 85.1 2.5 1.8 2 0 0 2 2 2 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ETS62070.1 - 0.00013 22.2 0.7 0.00024 21.4 0.7 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Band_3_cyto PF07565.13 ETS62070.1 - 0.15 11.8 0.6 0.22 11.3 0.6 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MBOAT PF03062.19 ETS62071.1 - 3.4e-52 177.9 17.2 3.4e-52 177.9 17.2 2.0 3 0 0 3 3 3 1 MBOAT, membrane-bound O-acyltransferase family PufQ PF05398.11 ETS62071.1 - 1.4 9.1 5.7 0.91 9.7 0.1 2.8 3 0 0 3 3 3 0 PufQ cytochrome subunit HemY_N PF07219.13 ETS62072.1 - 0.16 12.2 1.7 1.1 9.4 0.0 2.6 3 0 0 3 3 3 0 HemY protein N-terminus Phage_holin_3_6 PF07332.11 ETS62072.1 - 0.63 10.1 9.5 0.12 12.4 2.4 2.6 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Bot1p PF12298.8 ETS62074.1 - 2.3e-33 115.8 0.1 4e-33 115.0 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein MRP-L20 PF12824.7 ETS62074.1 - 0.00053 20.2 0.0 0.00093 19.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 EMC3_TMCO1 PF01956.16 ETS62075.1 - 6.9e-59 198.4 0.2 9.1e-59 198.0 0.2 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like NPR3 PF03666.13 ETS62076.1 - 1.3e-119 400.1 16.1 8.2e-119 397.4 0.0 3.4 3 1 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S24 PF00717.23 ETS62076.1 - 0.0014 18.6 0.0 0.018 15.0 0.0 2.3 2 0 0 2 2 2 1 Peptidase S24-like NPR2 PF06218.11 ETS62076.1 - 0.018 13.8 0.0 1.8 7.2 0.0 3.3 4 0 0 4 4 4 0 Nitrogen permease regulator 2 PEMT PF04191.13 ETS62077.1 - 2.2e-54 182.3 9.5 6.9e-32 110.0 1.6 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase DUF4199 PF13858.6 ETS62077.1 - 2.4 8.5 6.2 1.7 9.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) RRM_1 PF00076.22 ETS62078.1 - 3.8e-23 81.1 0.0 2e-11 43.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MAGE PF01454.19 ETS62079.1 - 4.1e-46 157.4 0.0 6.1e-46 156.8 0.0 1.3 1 0 0 1 1 1 1 MAGE family LRR_8 PF13855.6 ETS62080.1 - 1.4e-19 69.6 22.3 2e-10 40.3 8.5 5.3 4 1 1 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 ETS62080.1 - 2.8e-17 62.5 12.7 1e-05 25.8 3.9 5.4 5 0 0 5 5 5 4 Leucine Rich repeats (2 copies) Torus PF16131.5 ETS62080.1 - 3e-07 31.1 4.3 0.0039 17.9 0.4 2.6 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 ETS62080.1 - 1e-06 28.4 8.7 0.00088 19.0 1.2 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 ETS62080.1 - 7.5e-06 25.7 6.2 0.00052 19.9 0.7 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) LRR_1 PF00560.33 ETS62080.1 - 2.4e-05 24.2 15.2 9.6 7.2 0.1 7.4 7 0 0 7 7 7 1 Leucine Rich Repeat LRR_6 PF13516.6 ETS62080.1 - 0.00017 21.4 20.1 4.2 7.7 0.1 7.2 7 0 0 7 7 7 3 Leucine Rich repeat zf-CCCH_3 PF15663.5 ETS62080.1 - 0.00066 19.9 0.2 0.0015 18.7 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf_CCCH_4 PF18345.1 ETS62080.1 - 0.0014 18.6 15.7 0.0061 16.6 3.4 2.4 2 0 0 2 2 2 2 Zinc finger domain LRR_3 PF07725.12 ETS62080.1 - 0.039 13.8 0.4 0.039 13.8 0.4 2.4 2 0 0 2 2 2 0 Leucine Rich Repeat LRR_9 PF14580.6 ETS62080.1 - 0.14 11.7 0.4 0.73 9.3 0.5 1.9 2 0 0 2 2 2 0 Leucine-rich repeat adh_short PF00106.25 ETS62081.1 - 4.5e-24 85.0 5.2 1e-20 74.0 0.6 2.7 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS62081.1 - 8.6e-17 61.5 7.0 1.7e-13 50.7 1.2 2.7 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS62081.1 - 7.1e-09 35.8 0.1 1.2e-08 35.1 0.1 1.3 1 0 0 1 1 1 1 KR domain DUF2018 PF09442.10 ETS62081.1 - 0.0068 17.3 0.2 0.014 16.3 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2018) Epimerase PF01370.21 ETS62081.1 - 0.048 13.1 0.1 0.15 11.5 0.1 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Virulence_fact PF13769.6 ETS62081.1 - 0.084 13.1 0.1 0.31 11.3 0.1 1.9 1 0 0 1 1 1 0 Virulence factor MT-A70 PF05063.14 ETS62082.1 - 2.9e-50 170.5 0.0 1.3e-33 116.4 0.0 2.2 2 0 0 2 2 2 2 MT-A70 Torus PF16131.5 ETS62082.1 - 1.7 9.4 6.5 0.84 10.4 0.8 2.5 1 1 1 2 2 2 0 Torus domain WD40 PF00400.32 ETS62083.1 - 4e-29 100.2 27.5 1.6e-05 25.6 0.6 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 ETS62083.1 - 4.9e-09 35.9 0.3 1.2e-08 34.7 0.3 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ETS62083.1 - 7e-05 23.1 0.8 15 6.0 0.0 4.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ETS62083.1 - 0.00062 19.6 0.2 0.0016 18.3 0.2 1.8 1 0 0 1 1 1 1 F-box domain Frtz PF11768.8 ETS62083.1 - 0.17 10.2 0.0 0.29 9.4 0.0 1.3 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 ETS62083.1 - 1 8.0 4.6 5.4 5.5 0.1 2.7 3 0 0 3 3 3 0 Nucleoporin Nup120/160 HD PF01966.22 ETS62084.1 - 0.098 12.9 0.1 0.23 11.7 0.1 1.8 1 1 0 1 1 1 0 HD domain ADH_zinc_N PF00107.26 ETS62085.1 - 1e-10 41.7 0.2 1.6e-10 41.1 0.2 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ApbA PF02558.16 ETS62085.1 - 0.0011 18.6 0.1 0.0018 18.0 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ADH_zinc_N_2 PF13602.6 ETS62085.1 - 0.025 15.6 0.0 0.044 14.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Acyl-CoA_dh_2 PF08028.11 ETS62087.1 - 4.2e-12 46.5 1.8 7.4e-12 45.7 1.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETS62087.1 - 2.4e-07 31.4 0.4 1.2e-06 29.2 0.1 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETS62087.1 - 0.00027 21.1 0.0 0.00059 20.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ETS62087.1 - 0.056 13.6 1.2 0.21 11.8 1.2 2.0 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain RhlB PF12300.8 ETS62088.1 - 0.0064 16.6 9.2 0.015 15.4 7.6 2.3 1 1 1 2 2 2 1 ATP-dependent RNA helicase RhlB zf-C2H2_2 PF12756.7 ETS62088.1 - 0.032 14.6 0.1 0.064 13.6 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) OrsD PF12013.8 ETS62088.1 - 0.29 11.6 2.6 0.44 11.0 0.1 2.1 1 1 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D PI-PLC-X PF00388.19 ETS62089.1 - 1.2e-56 190.3 0.0 2.2e-56 189.5 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 ETS62089.1 - 1.2e-40 138.4 0.0 2.7e-40 137.3 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_7 PF13499.6 ETS62089.1 - 1.7e-06 28.4 2.2 3.4e-06 27.4 0.5 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETS62089.1 - 3.4e-05 23.1 0.1 0.16 11.6 0.0 3.0 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETS62089.1 - 0.00034 20.3 0.2 0.84 9.7 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain C2 PF00168.30 ETS62089.1 - 0.004 17.4 0.0 1.1 9.6 0.0 2.7 2 0 0 2 2 2 1 C2 domain EF-hand_10 PF14788.6 ETS62089.1 - 0.031 14.2 0.1 0.076 12.9 0.1 1.7 1 0 0 1 1 1 0 EF hand PH_12 PF16457.5 ETS62089.1 - 0.1 13.2 0.2 0.74 10.3 0.0 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain CreD PF06123.12 ETS62089.1 - 0.11 11.3 0.3 0.17 10.6 0.3 1.2 1 0 0 1 1 1 0 Inner membrane protein CreD EF-hand_8 PF13833.6 ETS62089.1 - 0.15 11.9 0.3 25 4.8 0.0 3.1 2 1 1 3 3 3 0 EF-hand domain pair DPBB_1 PF03330.18 ETS62090.1 - 2.7e-05 24.4 0.0 6.1e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Lytic transglycolase C6_DPF PF10170.9 ETS62090.1 - 0.12 12.8 0.8 0.18 12.2 0.8 1.2 1 0 0 1 1 1 0 Cysteine-rich domain ILVD_EDD PF00920.21 ETS62091.1 - 2.6e-185 616.9 0.1 7.2e-162 539.6 0.3 2.0 1 1 1 2 2 2 2 Dehydratase family Methyltransf_16 PF10294.9 ETS62092.1 - 9.9e-06 25.4 0.0 0.017 14.9 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_25 PF13649.6 ETS62092.1 - 0.00051 20.7 0.0 0.18 12.5 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ETS62092.1 - 0.0016 18.3 0.0 0.27 11.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain COX5B PF01215.19 ETS62092.1 - 0.2 11.4 0.0 0.34 10.6 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Vb GST_C_2 PF13410.6 ETS62093.1 - 3.1e-15 56.0 0.1 1.1e-14 54.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ETS62093.1 - 4e-06 27.1 0.0 7.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETS62093.1 - 4.1e-05 23.8 0.0 7.9e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ETS62093.1 - 0.089 13.2 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Torus PF16131.5 ETS62094.1 - 1.2e-29 103.2 4.8 5.9e-29 100.9 4.8 2.2 1 1 0 1 1 1 1 Torus domain RRM_1 PF00076.22 ETS62094.1 - 1.5e-07 31.1 0.1 5.6e-07 29.3 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETS62094.1 - 0.00028 20.8 0.0 0.00061 19.7 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif FANCA_interact PF15751.5 ETS62094.1 - 0.01 16.3 0.1 0.035 14.6 0.1 1.9 1 0 0 1 1 1 0 FAAP20 FANCA interaction domain zf-CCCH PF00642.24 ETS62094.1 - 0.016 15.1 5.3 0.031 14.2 5.3 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_3 PF08777.11 ETS62094.1 - 0.56 10.3 2.9 17 5.5 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif zf_CCCH_4 PF18345.1 ETS62094.1 - 0.58 10.3 5.3 1.1 9.4 5.3 1.5 1 0 0 1 1 1 0 Zinc finger domain LRR_6 PF13516.6 ETS62095.1 - 1.5e-12 46.5 28.1 0.0009 19.1 0.0 10.0 10 0 0 10 10 10 4 Leucine Rich repeat LRR_4 PF12799.7 ETS62095.1 - 0.00036 20.8 23.4 0.059 13.8 0.4 7.2 5 1 2 8 8 8 3 Leucine Rich repeats (2 copies) GAT PF03127.14 ETS62095.1 - 0.0074 16.6 0.0 0.025 14.9 0.0 2.0 1 0 0 1 1 1 1 GAT domain LRR_8 PF13855.6 ETS62095.1 - 0.07 12.9 21.8 6.4 6.6 0.0 6.9 5 1 2 7 7 7 0 Leucine rich repeat LRR_1 PF00560.33 ETS62095.1 - 0.25 12.0 18.9 54 4.9 0.0 8.4 10 1 0 10 10 10 0 Leucine Rich Repeat Pal1 PF08316.11 ETS62096.1 - 1.9e-12 48.1 0.4 1.9e-12 48.1 0.4 1.8 2 0 0 2 2 2 1 Pal1 cell morphology protein ATG22 PF11700.8 ETS62097.1 - 4.3e-136 454.3 14.0 5.1e-136 454.1 14.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 ETS62097.1 - 2.3e-11 43.3 27.9 2.2e-05 23.6 8.7 3.2 2 1 1 3 3 3 3 Major Facilitator Superfamily LAMTOR PF15454.6 ETS62098.1 - 0.002 18.7 0.8 0.0043 17.6 0.2 1.9 2 1 0 2 2 2 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator zf-RING_2 PF13639.6 ETS62099.1 - 1.6e-10 41.2 6.7 2.8e-10 40.4 6.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETS62099.1 - 3.1e-07 30.1 4.7 5.9e-07 29.2 4.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETS62099.1 - 5.6e-07 29.8 5.5 8.1e-07 29.2 4.7 1.7 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETS62099.1 - 9.9e-07 28.7 1.9 9.9e-07 28.7 1.9 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETS62099.1 - 4.5e-06 26.5 4.3 7.9e-06 25.7 4.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS62099.1 - 7.9e-06 25.6 8.5 0.00012 21.8 8.5 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETS62099.1 - 3.8e-05 23.2 1.7 8.7e-05 22.1 1.7 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ETS62099.1 - 6.8e-05 22.7 0.6 6.8e-05 22.7 0.6 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETS62099.1 - 0.0014 18.6 3.0 0.0026 17.8 3.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ETS62099.1 - 0.0038 16.9 2.9 0.023 14.4 2.9 2.3 1 1 0 1 1 1 1 RING-like zinc finger zf-Nse PF11789.8 ETS62099.1 - 0.026 14.3 3.7 0.054 13.3 3.7 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING-like PF08746.11 ETS62099.1 - 0.028 14.7 0.9 0.071 13.4 0.9 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4_3 PF13920.6 ETS62099.1 - 0.039 13.8 8.3 0.45 10.4 8.5 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Shisa PF13908.6 ETS62099.1 - 0.059 13.6 0.0 0.18 12.0 0.0 1.8 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator FANCL_C PF11793.8 ETS62099.1 - 0.093 12.9 4.8 0.64 10.2 4.8 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ETS62099.1 - 0.16 12.1 5.1 0.51 10.5 5.1 1.8 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 ETS62099.1 - 0.33 10.8 5.8 1.4 8.8 5.9 1.9 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ETS62099.1 - 0.37 11.0 6.7 0.2 11.8 0.3 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF1729 PF08354.10 ETS62100.1 - 1e-161 537.7 0.0 1.7e-161 537.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) FAS_I_H PF18314.1 ETS62100.1 - 2.3e-77 259.2 0.3 4.2e-77 258.4 0.3 1.4 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 ETS62100.1 - 2.2e-68 229.7 0.0 4.4e-68 228.7 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain Acyl_transf_1 PF00698.21 ETS62100.1 - 1.7e-61 208.5 0.0 5.5e-61 206.8 0.0 1.9 2 0 0 2 2 1 1 Acyl transferase domain FAS_meander PF17951.1 ETS62100.1 - 2.2e-45 154.0 0.0 4.8e-45 153.0 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain ketoacyl-synt PF00109.26 ETS62100.1 - 5.4e-27 95.0 0.3 1.3e-26 93.7 0.3 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydratas PF01575.19 ETS62100.1 - 1e-26 92.9 0.2 8.2e-26 90.0 0.0 2.3 2 0 0 2 2 2 1 MaoC like domain SAT PF16073.5 ETS62100.1 - 1.7e-24 86.9 1.0 2.8e-24 86.2 0.0 1.8 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ETS62100.1 - 1.4e-17 63.7 2.7 2.4e-17 63.0 0.5 2.5 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain ACPS PF01648.20 ETS62100.1 - 1.3e-12 47.8 0.0 1.1e-11 44.9 0.0 2.4 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily FAS_N PF17828.1 ETS62100.1 - 2.1e-11 43.9 0.1 4.8e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 ETS62100.1 - 1.4e-09 38.2 0.0 4.5e-09 36.5 0.0 1.9 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase adh_short PF00106.25 ETS62100.1 - 9.3e-05 22.0 0.0 0.00066 19.2 0.0 2.3 2 0 0 2 2 2 1 short chain dehydrogenase Thiolase_N PF00108.23 ETS62100.1 - 0.0063 15.9 0.5 0.022 14.1 0.1 2.0 2 0 0 2 2 2 1 Thiolase, N-terminal domain KR PF08659.10 ETS62100.1 - 0.064 13.2 0.3 1.6 8.6 0.0 2.8 2 0 0 2 2 2 0 KR domain DUF3597 PF12200.8 ETS62100.1 - 0.58 10.7 4.3 2.2 8.8 4.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) DUF3306 PF11748.8 ETS62100.1 - 7.6 7.4 11.0 3.7 8.4 0.9 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) LETM1 PF07766.13 ETS62101.1 - 1.1e-22 80.7 0.3 1.6e-11 44.0 0.0 2.2 1 1 0 2 2 2 2 LETM1-like protein UQ_con PF00179.26 ETS62102.1 - 1.1e-36 125.5 0.0 1.7e-36 125.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Astro_capsid_p2 PF16580.5 ETS62102.1 - 0.032 13.7 0.5 0.047 13.1 0.5 1.2 1 0 0 1 1 1 0 C-terminal tail of astrovirus capsid projection or spike LSM PF01423.22 ETS62103.1 - 2.7e-16 59.0 0.8 4.2e-16 58.4 0.8 1.3 1 0 0 1 1 1 1 LSM domain NDK PF00334.19 ETS62104.1 - 4.1e-51 172.5 0.0 5.8e-51 172.0 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Sin_N PF04801.13 ETS62105.1 - 2.8e-32 112.5 0.0 4.5e-32 111.8 0.0 1.3 1 0 0 1 1 1 1 Sin-like protein conserved region Serglycin PF04360.12 ETS62105.1 - 0.25 11.3 2.1 1.2 9.0 0.2 2.2 2 0 0 2 2 2 0 Serglycin Pex24p PF06398.11 ETS62106.1 - 5.2e-27 94.8 3.9 2.4e-26 92.6 0.1 2.3 2 1 0 2 2 2 2 Integral peroxisomal membrane peroxin Gtr1_RagA PF04670.12 ETS62107.1 - 5.2e-25 88.1 0.1 7.9e-10 38.5 0.0 4.1 4 0 0 4 4 4 4 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ETS62107.1 - 0.0033 17.8 0.0 0.0083 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ETS62107.1 - 0.0055 16.8 0.0 0.014 15.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ETS62107.1 - 0.15 11.5 0.1 2.3 7.7 0.1 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_14 PF13173.6 ETS62107.1 - 0.18 11.9 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNase_P_pop3 PF08228.11 ETS62108.1 - 7.7e-05 22.8 0.0 0.00018 21.6 0.0 1.7 1 0 0 1 1 1 1 RNase P subunit Pop3 DUF1640 PF07798.11 ETS62108.1 - 0.083 12.9 1.7 0.19 11.8 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) RPN13_C PF16550.5 ETS62108.1 - 0.098 12.8 6.5 1 9.6 0.1 3.3 2 1 2 4 4 4 0 UCH-binding domain Di19_C PF14571.6 ETS62108.1 - 5.4 7.6 12.3 0.26 11.8 4.7 2.6 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Oxysterol_BP PF01237.18 ETS62109.1 - 3.8e-51 174.1 1.1 9.3e-26 90.5 0.1 4.2 2 1 1 3 3 3 3 Oxysterol-binding protein VCX_VCY PF15231.6 ETS62109.1 - 2.6 8.8 12.3 9.2 6.9 6.9 2.8 2 1 0 2 2 2 0 Variable charge X/Y family Ada3 PF10198.9 ETS62110.1 - 4.1e-32 111.1 0.2 4.1e-32 111.1 0.2 2.2 3 0 0 3 3 3 1 Histone acetyltransferases subunit 3 HEAT PF02985.22 ETS62111.1 - 6.6e-38 125.5 18.4 0.0038 17.4 0.0 13.7 14 0 0 14 14 14 10 HEAT repeat HEAT_2 PF13646.6 ETS62111.1 - 3e-34 117.3 10.0 7.7e-12 45.4 0.0 7.4 2 2 5 7 7 7 6 HEAT repeats Vac14_Fab1_bd PF12755.7 ETS62111.1 - 1.8e-11 44.5 1.4 0.0089 16.6 0.0 6.9 4 2 4 8 8 8 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ETS62111.1 - 4.3e-11 43.1 11.9 0.00066 20.1 0.2 8.6 6 2 3 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 ETS62111.1 - 5.7e-09 36.2 9.2 0.0074 16.4 0.0 5.5 4 2 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETS62111.1 - 1.8e-06 26.8 7.2 0.027 13.0 0.1 4.7 3 1 1 5 5 5 3 Adaptin N terminal region RTP1_C1 PF10363.9 ETS62111.1 - 0.0003 20.9 3.0 4.9 7.4 0.0 4.3 3 2 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 ETS62111.1 - 0.0087 15.6 1.5 0.65 9.5 0.1 4.1 2 2 3 5 5 5 1 CLASP N terminal Med24_N PF11277.8 ETS62111.1 - 0.015 13.4 0.1 0.023 12.8 0.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal V-ATPase_H_N PF03224.14 ETS62111.1 - 0.024 13.9 0.6 0.48 9.7 0.6 2.8 1 1 0 1 1 1 0 V-ATPase subunit H Proteasom_PSMB PF10508.9 ETS62111.1 - 0.045 12.3 1.6 8.9 4.7 0.1 3.3 3 1 0 3 3 3 0 Proteasome non-ATPase 26S subunit API5 PF05918.11 ETS62111.1 - 0.058 12.2 0.5 0.52 9.1 0.1 2.7 2 1 0 2 2 2 0 Apoptosis inhibitory protein 5 (API5) HEAT_PBS PF03130.16 ETS62111.1 - 0.085 13.6 0.1 22 6.1 0.0 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat TTRAP PF14203.6 ETS62111.1 - 0.18 11.8 0.2 93 3.1 0.0 4.1 4 0 0 4 4 4 0 Putative tranposon-transfer assisting protein ACBP PF00887.19 ETS62112.1 - 1.9e-30 104.9 0.3 2.7e-30 104.4 0.3 1.2 1 0 0 1 1 1 1 Acyl CoA binding protein DUF3961 PF13106.6 ETS62112.1 - 0.032 13.9 0.5 0.083 12.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3961) SWIB PF02201.18 ETS62113.1 - 1.8e-22 79.0 0.0 3.1e-22 78.2 0.0 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain PRP1_N PF06424.12 ETS62113.1 - 1.6 9.1 7.2 0.97 9.8 0.3 2.8 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Memo PF01875.17 ETS62114.1 - 1.4e-75 253.9 0.0 3.1e-75 252.8 0.0 1.5 1 1 0 1 1 1 1 Memo-like protein Ribosomal_S3_C PF00189.20 ETS62115.1 - 6e-24 84.4 1.7 1.2e-23 83.4 0.5 2.1 3 0 0 3 3 3 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ETS62115.1 - 5.6e-13 48.5 0.0 9.7e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 ETS62115.1 - 0.044 14.3 0.0 0.089 13.3 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 ETS62115.1 - 0.29 10.9 1.1 0.53 10.1 0.0 1.9 2 0 0 2 2 2 0 Coilin N-terminus HABP4_PAI-RBP1 PF04774.15 ETS62116.1 - 4.8e-11 43.5 7.5 4.8e-11 43.5 7.5 2.8 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family Stm1_N PF09598.10 ETS62116.1 - 0.0098 16.7 16.2 0.0098 16.7 16.2 4.8 2 2 0 2 2 2 1 Stm1 Arrestin_N PF00339.29 ETS62117.1 - 2.2e-07 31.0 0.0 4.9e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ETS62117.1 - 0.00029 21.3 0.0 0.083 13.3 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.11 ETS62117.1 - 0.0028 17.2 0.0 0.0061 16.1 0.0 1.5 1 0 0 1 1 1 1 SpoOM protein SSF PF00474.17 ETS62119.1 - 4.7e-12 45.5 18.4 1.3e-11 44.0 18.4 1.8 1 1 0 1 1 1 1 Sodium:solute symporter family RPAP2_Rtr1 PF04181.13 ETS62120.1 - 2.4e-18 66.2 0.0 4.3e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Rtr1/RPAP2 family DAP3 PF10236.9 ETS62120.1 - 0.056 12.6 0.1 0.084 12.0 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NUDIX PF00293.28 ETS62121.1 - 1.2e-10 41.5 0.0 2.9e-10 40.3 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain TIMELESS PF04821.14 ETS62122.1 - 1.7e-73 247.3 0.0 5.5e-73 245.6 0.0 1.9 1 0 0 1 1 1 1 Timeless protein DCP1 PF06058.13 ETS62123.1 - 1.7e-32 111.8 0.0 2.6e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 ETS62123.1 - 9.4e-06 24.8 0.0 1.6e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 mRNA-decapping enzyme C-terminus HNOBA PF07701.14 ETS62123.1 - 0.0037 16.7 0.8 0.0048 16.4 0.8 1.3 1 0 0 1 1 1 1 Heme NO binding associated DUF4746 PF15928.5 ETS62123.1 - 0.21 11.0 11.1 0.32 10.4 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) VPS38 PF17649.1 ETS62123.1 - 0.26 10.1 1.5 0.36 9.6 1.5 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 38 CDC45 PF02724.14 ETS62123.1 - 0.34 9.2 6.9 0.42 8.9 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.11 ETS62123.1 - 0.42 10.6 23.2 0.11 12.5 18.3 2.3 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) NARP1 PF12569.8 ETS62123.1 - 0.52 9.2 14.8 0.74 8.7 14.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SAPS PF04499.15 ETS62123.1 - 1.5 7.5 6.7 1.9 7.2 6.7 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Rtf2 PF04641.12 ETS62123.1 - 1.7 7.9 13.8 2.8 7.2 13.8 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger SR-25 PF10500.9 ETS62123.1 - 2.4 7.7 19.9 0.02 14.5 11.0 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MDM10 PF12519.8 ETS62123.1 - 3.4 6.4 5.5 4.5 6.0 5.5 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Med24_N PF11277.8 ETS62123.1 - 4.7 5.1 6.0 6.8 4.6 6.0 1.1 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal DUF2151 PF10221.9 ETS62123.1 - 5 5.6 9.6 6.6 5.2 9.6 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Yippee-Mis18 PF03226.14 ETS62124.1 - 5.8e-23 81.1 0.1 8.4e-23 80.6 0.1 1.2 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF5320 PF17253.2 ETS62124.1 - 0.01 16.9 0.1 0.031 15.3 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5320) FXMRP1_C_core PF12235.8 ETS62124.1 - 0.024 15.3 2.9 0.024 15.3 2.9 1.8 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal FoP_duplication PF13865.6 ETS62124.1 - 2.9 8.5 7.9 5.7 7.6 7.9 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Redoxin PF08534.10 ETS62125.1 - 7.4e-33 113.3 0.1 1.1e-32 112.7 0.1 1.3 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ETS62125.1 - 1.8e-06 27.9 0.0 2.6e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Aa_trans PF01490.18 ETS62126.1 - 1.2e-80 271.2 33.0 1.5e-80 270.9 33.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PTPRCAP PF15713.5 ETS62126.1 - 0.0074 16.6 3.6 0.0074 16.6 3.6 1.5 2 0 0 2 2 2 1 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 ETS62126.1 - 0.085 11.1 3.5 0.15 10.3 3.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.13 ETS62126.1 - 0.33 10.8 2.1 0.58 10.0 2.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Pes-10 PF07149.11 ETS62126.1 - 2.1 7.3 3.9 0.47 9.4 0.4 1.7 2 0 0 2 2 2 0 Pes-10 UCR_TM PF02921.14 ETS62126.1 - 2.2 8.8 7.9 0.38 11.3 0.4 3.5 4 0 0 4 4 4 0 Ubiquinol cytochrome reductase transmembrane region NOA36 PF06524.12 ETS62126.1 - 3.9 6.7 9.1 6.7 5.9 9.1 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETS62126.1 - 5.2 5.1 9.8 7.3 4.5 9.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi PHO4 PF01384.20 ETS62126.1 - 5.5 5.9 20.1 67 2.4 19.7 2.6 1 1 0 1 1 1 0 Phosphate transporter family DUF3395 PF11875.8 ETS62127.1 - 7.5e-43 146.1 0.0 1.5e-42 145.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 ETS62127.1 - 2.2e-21 75.7 0.9 3.8e-21 75.0 0.9 1.4 1 0 0 1 1 1 1 DnaJ domain Med5 PF08689.10 ETS62128.1 - 1.3e-21 76.3 0.0 3.5e-21 74.9 0.0 1.7 1 1 0 1 1 1 1 Mediator complex subunit Med5 Hpt PF01627.23 ETS62128.1 - 1.8 8.8 10.1 0.4 11.0 0.5 4.1 4 0 0 4 4 4 0 Hpt domain Amidohydro_1 PF01979.20 ETS62129.1 - 8.5e-58 196.3 0.0 2.4e-43 148.8 0.0 3.1 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 ETS62129.1 - 6.3e-05 22.6 0.0 1.1 8.7 0.0 3.3 3 0 0 3 3 3 3 Amidohydrolase family PAPS_reduct PF01507.19 ETS62130.1 - 7e-37 127.1 0.0 1.4e-36 126.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Atg14 PF10186.9 ETS62131.1 - 4.3e-09 35.9 0.5 7.6e-09 35.1 0.5 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Ribosomal_L36 PF00444.18 ETS62133.1 - 4.7e-22 77.9 8.0 7e-22 77.3 8.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 VBS PF08913.10 ETS62133.1 - 0.015 15.7 2.0 0.018 15.5 2.0 1.1 1 0 0 1 1 1 0 Vinculin Binding Site Ctf8 PF09696.10 ETS62134.1 - 5.3e-14 52.7 3.4 6.4e-11 42.8 3.4 3.0 1 1 0 1 1 1 1 Ctf8 DUF5549 PF17703.1 ETS62134.1 - 0.0023 17.6 1.0 0.0081 15.8 0.9 1.9 1 1 1 2 2 2 1 Family of unknown function (DUF5549) VIR_N PF15912.5 ETS62134.1 - 0.025 14.2 3.6 0.037 13.6 3.6 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal ASH PF15780.5 ETS62135.1 - 1.3e-16 60.6 0.0 0.033 14.4 0.1 6.8 8 0 0 8 8 8 4 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 ETS62135.1 - 5.7e-07 29.6 0.1 0.2 11.8 0.1 4.8 5 0 0 5 5 5 2 Flagellar-associated PapD-like TMEM131_like PF12371.8 ETS62135.1 - 0.00044 20.5 0.5 28 5.0 0.0 6.2 6 1 2 8 8 8 2 Transmembrane protein 131-like PUF PF00806.19 ETS62137.1 - 1.6e-09 36.9 0.0 0.0015 18.1 0.0 6.0 7 0 0 7 7 7 3 Pumilio-family RNA binding repeat Frag1 PF10277.9 ETS62139.1 - 2.1e-31 109.1 6.1 2.1e-31 109.1 6.1 2.3 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family SLD5_C PF16922.5 ETS62141.1 - 1.7e-13 50.5 0.0 3.2e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus TRAM_LAG1_CLN8 PF03798.16 ETS62142.1 - 5.4e-32 111.1 28.1 5.4e-32 111.1 28.1 2.4 3 0 0 3 3 3 1 TLC domain TRAM1 PF08390.11 ETS62142.1 - 1.1e-23 82.7 0.1 1.1e-23 82.7 0.1 2.5 3 0 0 3 3 3 1 TRAM1-like protein Succ_CoA_lig PF13607.6 ETS62142.1 - 0.052 13.3 0.8 0.11 12.3 0.8 1.4 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain Amnionless PF14828.6 ETS62143.1 - 0.0064 15.4 1.0 0.036 12.9 0.0 2.0 1 1 1 2 2 2 1 Amnionless Utp14 PF04615.13 ETS62143.1 - 0.052 12.1 2.9 0.065 11.8 2.9 1.1 1 0 0 1 1 1 0 Utp14 protein DUF1279 PF06916.13 ETS62144.1 - 5.7e-22 78.1 0.0 9.5e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Ribosomal_L13e PF01294.18 ETS62145.1 - 2e-74 249.3 7.6 3.1e-74 248.7 7.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e HAD_2 PF13419.6 ETS62146.1 - 8.2e-21 74.9 0.0 1.8e-20 73.8 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETS62146.1 - 6.2e-14 52.8 0.0 2.5e-12 47.5 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS62146.1 - 6.1e-06 26.2 0.0 1.4e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ETS62146.1 - 0.0027 18.2 0.0 0.0053 17.2 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4774 PF15999.5 ETS62146.1 - 0.045 13.6 1.0 0.11 12.4 1.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4774) Hydrolase_3 PF08282.12 ETS62146.1 - 0.11 12.2 0.2 1 9.0 0.1 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETS62146.1 - 0.16 12.1 0.0 1.4 9.1 0.0 2.6 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase His_Phos_1 PF00300.22 ETS62148.1 - 3.8e-23 82.2 0.0 5.7e-23 81.6 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Dus PF01207.17 ETS62149.1 - 1.3e-40 139.5 0.2 2.2e-40 138.7 0.2 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Pyridox_oxase_2 PF12766.7 ETS62149.1 - 2.4e-23 82.6 0.0 7.5e-23 81.0 0.0 1.8 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Vps39_1 PF10366.9 ETS62150.1 - 1.3e-30 105.9 0.1 4.4e-30 104.1 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 ETS62150.1 - 1.3e-24 86.7 0.2 2.7e-24 85.7 0.2 1.5 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 ETS62150.1 - 6.3e-13 49.0 0.0 0.00064 19.4 0.0 3.3 3 0 0 3 3 3 3 CNH domain Clathrin PF00637.20 ETS62150.1 - 1e-07 31.9 0.2 0.0031 17.4 0.0 3.7 3 1 0 3 3 3 2 Region in Clathrin and VPS TPR_19 PF14559.6 ETS62150.1 - 0.0085 16.6 0.2 0.081 13.4 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat CHASE6_C PF17150.4 ETS62150.1 - 0.073 13.7 0.1 0.96 10.2 0.0 2.5 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain RHS PF03527.14 ETS62150.1 - 0.14 12.0 0.2 0.33 10.8 0.2 1.6 1 0 0 1 1 1 0 RHS protein DUF1828 PF08861.10 ETS62150.1 - 0.16 12.3 0.0 20 5.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF1828 TPR_5 PF12688.7 ETS62150.1 - 0.94 9.7 4.0 1.3 9.3 0.2 2.8 2 1 0 2 2 2 0 Tetratrico peptide repeat TPR_12 PF13424.6 ETS62150.1 - 1.3 9.4 9.9 0.41 11.0 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Aminotran_3 PF00202.21 ETS62151.1 - 1.5e-33 116.1 0.0 8.9e-16 57.5 0.1 3.1 3 0 0 3 3 3 3 Aminotransferase class-III AAA_26 PF13500.6 ETS62151.1 - 2.6e-10 40.5 0.0 1.3e-08 34.9 0.0 2.6 2 1 0 2 2 2 1 AAA domain DGCR6 PF07324.11 ETS62152.1 - 0.00054 19.6 1.2 0.00093 18.9 1.2 1.3 1 0 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein DUF444 PF04285.12 ETS62152.1 - 0.07 12.2 2.2 0.093 11.8 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF444) Strabismus PF06638.11 ETS62152.1 - 0.25 9.9 5.2 0.34 9.5 5.2 1.1 1 0 0 1 1 1 0 Strabismus protein Nsp1_C PF05064.13 ETS62152.1 - 0.46 10.3 3.7 9.4 6.1 0.2 2.6 2 1 1 3 3 3 0 Nsp1-like C-terminal region DUF3123 PF11321.8 ETS62152.1 - 3.6 8.3 6.9 1.2 9.8 3.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3123) THUMP PF02926.17 ETS62153.1 - 8.4e-09 35.7 0.0 1.8e-08 34.6 0.0 1.5 1 0 0 1 1 1 1 THUMP domain BAF1_ABF1 PF04684.13 ETS62153.1 - 4.1 6.4 12.5 0.12 11.4 1.2 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor HEAT_EZ PF13513.6 ETS62154.1 - 1.9e-09 37.8 14.7 0.09 13.3 0.0 8.3 5 1 1 6 6 6 2 HEAT-like repeat Adaptin_N PF01602.20 ETS62154.1 - 0.0004 19.1 0.9 0.023 13.3 0.0 3.8 4 1 0 4 4 4 1 Adaptin N terminal region Arm PF00514.23 ETS62154.1 - 0.00074 19.5 4.0 0.0069 16.4 0.3 4.1 2 1 1 3 3 3 1 Armadillo/beta-catenin-like repeat Vac14_Fab1_bd PF12755.7 ETS62154.1 - 0.0022 18.5 0.0 0.35 11.5 0.0 3.8 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ETS62154.1 - 0.0055 16.8 25.7 0.31 11.4 0.0 9.4 10 0 0 10 10 10 2 HEAT repeat Cnd3 PF12719.7 ETS62154.1 - 0.0074 15.5 0.1 8.3 5.5 0.0 3.6 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 ETS62154.1 - 0.046 13.8 3.2 17 5.4 0.0 5.6 6 1 1 7 7 7 0 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETS62154.1 - 0.054 13.9 26.6 9.9 6.6 1.4 8.7 7 2 2 9 9 9 0 HEAT repeats DUF3245 PF11595.8 ETS62154.1 - 0.086 13.3 0.5 0.2 12.1 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) UCH PF00443.29 ETS62155.1 - 4.1e-38 131.3 0.0 1.7e-37 129.3 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 ETS62155.1 - 6.7e-20 70.8 11.0 7.5e-17 61.0 3.1 3.7 3 0 0 3 3 3 3 A repeated domain in UCH-protein UCH_1 PF13423.6 ETS62155.1 - 2.1e-05 24.3 0.0 0.1 12.2 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase MCM_bind PF09739.9 ETS62155.1 - 0.29 9.5 1.5 0.45 8.9 0.3 1.7 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor CENP-F_leu_zip PF10473.9 ETS62155.1 - 0.41 10.6 4.1 2.5 8.1 0.1 2.9 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Vps8 PF12816.7 ETS62157.1 - 4.2e-70 235.3 0.0 9.6e-70 234.1 0.0 1.7 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 ANAPC4_WD40 PF12894.7 ETS62157.1 - 0.02 15.2 0.0 0.052 13.9 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETS62157.1 - 0.19 12.7 0.5 0.61 11.0 0.5 2.0 1 0 0 1 1 1 0 WD domain, G-beta repeat PQQ_3 PF13570.6 ETS62157.1 - 0.23 12.0 1.0 1 10.0 0.1 2.6 2 0 0 2 2 2 0 PQQ-like domain dUTPase PF00692.19 ETS62158.1 - 2.9e-44 149.9 0.0 3.9e-44 149.4 0.0 1.1 1 0 0 1 1 1 1 dUTPase Dynamin_N PF00350.23 ETS62159.1 - 5.1e-44 150.3 0.0 2.3e-43 148.2 0.0 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 ETS62159.1 - 1e-05 25.6 0.0 0.00017 21.6 0.0 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 ETS62159.1 - 1.7e-05 24.2 0.1 0.0016 17.7 0.1 3.0 2 1 0 2 2 2 1 Dynamin central region AAA_21 PF13304.6 ETS62159.1 - 0.045 13.5 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 ETS62159.1 - 0.054 12.8 0.0 0.16 11.3 0.0 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_15 PF13175.6 ETS62159.1 - 0.073 12.8 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain YtxH PF12732.7 ETS62159.1 - 0.37 11.4 2.0 2.6 8.6 0.1 3.3 4 0 0 4 4 4 0 YtxH-like protein Cation_efflux PF01545.21 ETS62160.1 - 3.8e-49 167.1 16.0 8.5e-49 166.0 16.0 1.6 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETS62160.1 - 0.029 14.5 0.1 0.062 13.4 0.1 1.5 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter RPN1_RPN2_N PF17781.1 ETS62161.1 - 4.1e-122 407.4 0.5 6e-122 406.9 0.5 1.2 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 ETS62161.1 - 3.4e-27 94.2 0.0 6.3e-27 93.4 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 ETS62161.1 - 5.7e-18 64.4 17.1 0.0039 17.6 0.1 8.1 7 0 0 7 7 7 5 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ETS62161.1 - 0.00081 19.7 2.1 0.68 10.4 0.0 4.5 3 1 1 4 4 4 2 HEAT repeats DUF4705 PF15788.5 ETS62162.1 - 1.1 9.6 7.2 2.1 8.7 0.2 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4705) Bac_surface_Ag PF01103.23 ETS62164.1 - 3e-34 119.0 0.0 1.4e-33 116.8 0.0 1.9 1 1 0 1 1 1 1 Surface antigen RNA_pol_Rbc25 PF08292.12 ETS62165.1 - 2.2e-42 144.3 0.0 3.1e-42 143.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 ETS62165.1 - 3.8e-19 68.8 0.0 6.8e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ETS62165.1 - 0.04 14.3 0.0 0.069 13.5 0.0 1.4 1 0 0 1 1 1 0 S1 RNA binding domain RhoGAP PF00620.27 ETS62166.1 - 2.7e-37 128.0 0.0 4e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain DUF1708 PF08101.11 ETS62166.1 - 0.004 16.4 0.0 0.0069 15.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) SAPS PF04499.15 ETS62167.1 - 3.1 6.5 8.9 3.5 6.3 8.9 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF1741 PF08427.10 ETS62169.1 - 6.5e-24 84.9 0.0 1.1e-23 84.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) DDE_Tnp_1_assoc PF13808.6 ETS62169.1 - 0.11 12.6 0.8 1 9.4 0.0 3.0 3 0 0 3 3 3 0 DDE_Tnp_1-associated SEP PF08059.13 ETS62170.1 - 1.7e-24 86.2 0.0 3.4e-24 85.2 0.0 1.5 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 ETS62170.1 - 4.7e-18 65.2 0.0 7.5e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ETS62170.1 - 9.8e-16 57.3 0.3 1.8e-15 56.5 0.3 1.5 1 0 0 1 1 1 1 UBA-like domain Tim17 PF02466.19 ETS62171.1 - 3.4e-08 33.8 11.1 8.4e-08 32.6 11.2 1.6 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 ETS62171.1 - 0.019 15.1 7.6 0.28 11.3 5.7 2.3 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III 5TM-5TMR_LYT PF07694.12 ETS62171.1 - 0.74 9.3 7.5 0.51 9.8 5.5 1.6 1 1 1 2 2 2 0 5TMR of 5TMR-LYT tRNA_bind PF01588.20 ETS62172.1 - 5.9e-27 93.6 0.0 1.3e-26 92.5 0.0 1.6 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C PF00043.25 ETS62172.1 - 4.6e-05 23.5 0.1 4.6e-05 23.5 0.1 2.5 2 1 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ETS62172.1 - 0.0016 18.2 0.0 0.0038 17.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETS62172.1 - 0.0027 17.7 0.0 0.0067 16.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS62172.1 - 0.008 16.4 0.1 0.008 16.4 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GAGA_bind PF06217.12 ETS62172.1 - 0.025 14.9 2.1 0.033 14.5 2.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family THOC2_N PF16134.5 ETS62172.1 - 0.37 9.4 11.8 0.59 8.7 11.8 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus DUF5427 PF10310.9 ETS62172.1 - 0.64 8.9 8.8 0.98 8.3 8.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RNA_pol_Rpc4 PF05132.14 ETS62172.1 - 1.7 9.1 9.2 3.5 8.1 9.2 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 ETS62172.1 - 8.2 6.2 11.3 14 5.4 11.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 ETS62172.1 - 8.8 5.0 7.3 13 4.4 7.3 1.2 1 0 0 1 1 1 0 Raftlin adh_short PF00106.25 ETS62173.1 - 3.7e-06 26.5 0.0 0.033 13.6 0.0 3.2 3 1 0 3 3 3 2 short chain dehydrogenase Astro_capsid_p PF12226.8 ETS62173.1 - 4.5 6.3 8.2 7.8 5.5 8.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein UDPGP PF01704.18 ETS62175.1 - 1e-46 159.4 0.0 1.3e-46 159.1 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Ribosomal_L4 PF00573.22 ETS62176.1 - 2.2e-41 141.7 0.6 3.6e-41 141.0 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ETS62176.1 - 1.6e-29 101.7 3.3 6.1e-29 99.9 0.6 2.5 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain RCDG1 PF15725.5 ETS62176.1 - 0.59 10.6 0.1 0.59 10.6 0.1 2.5 3 0 0 3 3 3 0 Renal cancer differentiation gene 1 protein Aconitase PF00330.20 ETS62177.1 - 2.3e-153 511.5 0.0 2.9e-153 511.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ETS62177.1 - 3.5e-42 143.8 0.1 8.2e-42 142.6 0.0 1.7 2 0 0 2 2 2 1 Aconitase C-terminal domain DUF521 PF04412.13 ETS62177.1 - 0.02 13.6 0.1 0.067 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF521) MFS_1 PF07690.16 ETS62178.1 - 3.7e-29 101.8 50.2 2.9e-27 95.5 27.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS62178.1 - 6.3e-19 68.2 13.5 1.1e-17 64.0 13.2 2.2 1 1 0 1 1 1 1 Sugar (and other) transporter Chalcone_2 PF16035.5 ETS62179.1 - 4.7e-33 114.7 1.1 8.7e-30 104.0 1.1 2.7 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 ETS62179.1 - 2.6e-05 24.4 0.1 0.00013 22.1 0.1 2.0 1 1 0 1 1 1 1 Chalcone isomerase-like DHC_N2 PF08393.13 ETS62179.1 - 0.08 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 2 Adeno_PIX PF03955.14 ETS62179.1 - 0.61 10.3 6.6 1.4 9.1 6.6 1.6 1 0 0 1 1 1 0 Adenovirus hexon-associated protein (IX) Acetyltransf_1 PF00583.25 ETS62180.1 - 6.7e-15 55.4 0.0 8.2e-15 55.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS62180.1 - 3.4e-10 40.2 0.1 4.8e-10 39.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS62180.1 - 3.5e-10 39.9 0.0 4.5e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS62180.1 - 0.0024 17.8 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ETS62180.1 - 0.024 14.7 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETS62180.1 - 0.026 14.7 0.1 0.045 13.9 0.1 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_4 PF13420.7 ETS62180.1 - 0.037 14.2 0.0 0.045 13.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain TMEM154 PF15102.6 ETS62182.1 - 0.14 12.0 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 TMEM154 protein family V-SNARE_C PF12352.8 ETS62183.1 - 0.0098 16.2 2.7 0.77 10.1 0.4 2.6 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus Neur_chan_memb PF02932.16 ETS62183.1 - 0.089 12.8 3.7 0.15 12.1 3.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PSD1 PF07587.11 ETS62183.1 - 0.21 11.0 5.7 0.03 13.8 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1553) DUF1490 PF07371.12 ETS62183.1 - 1.1 9.4 3.8 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1490) Prefoldin_2 PF01920.20 ETS62184.1 - 1.2e-17 63.8 9.4 1.7e-17 63.3 9.4 1.2 1 0 0 1 1 1 1 Prefoldin subunit CLZ PF16526.5 ETS62184.1 - 0.042 14.2 2.0 0.042 14.2 2.0 2.1 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels EMP24_GP25L PF01105.24 ETS62184.1 - 0.071 13.0 5.6 0.51 10.3 0.5 2.0 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF2408 PF10303.9 ETS62184.1 - 0.073 13.6 6.8 0.099 13.2 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) WSD PF15613.6 ETS62184.1 - 0.14 12.6 3.3 1.3 9.5 0.2 2.1 2 0 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DUF5320 PF17253.2 ETS62184.1 - 0.6 11.2 0.2 0.6 11.2 0.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) NPV_P10 PF05531.12 ETS62184.1 - 0.64 10.5 8.6 3.3 8.3 1.8 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4795 PF16043.5 ETS62184.1 - 2.2 7.8 11.4 0.76 9.3 4.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Fib_alpha PF08702.10 ETS62184.1 - 2.3 8.4 9.2 6.1 7.0 4.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family LMBR1 PF04791.16 ETS62184.1 - 5 5.9 5.5 7 5.4 5.5 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein Baculo_PEP_C PF04513.12 ETS62184.1 - 5.4 7.0 12.5 70 3.5 11.0 2.2 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus XhlA PF10779.9 ETS62184.1 - 5.9 7.2 6.9 1.1 9.5 0.9 2.1 2 1 0 2 2 2 0 Haemolysin XhlA DUF4349 PF14257.6 ETS62184.1 - 6.5 6.1 11.3 3.9 6.9 2.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) ZapB PF06005.12 ETS62184.1 - 6.9 7.2 16.8 4.1 7.9 7.0 2.3 2 0 0 2 2 2 0 Cell division protein ZapB Swi5 PF07061.11 ETS62184.1 - 8.3 6.6 10.9 13 5.9 2.7 2.2 2 0 0 2 2 2 0 Swi5 RhoGEF PF00621.20 ETS62185.1 - 3.2e-13 50.3 0.0 1.2e-08 35.5 0.0 2.3 2 0 0 2 2 2 2 RhoGEF domain DUF808 PF05661.12 ETS62185.1 - 0.76 8.8 2.3 1.3 8.0 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF808) CSTF2_hinge PF14327.6 ETS62186.1 - 1.4e-33 115.2 2.1 1.4e-33 115.2 2.1 2.1 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 ETS62186.1 - 4.9e-23 80.7 0.0 8.3e-23 80.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 ETS62186.1 - 2.1e-14 52.8 9.3 2.9e-14 52.4 5.2 2.6 2 0 0 2 2 2 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 ETS62186.1 - 0.00069 19.7 0.1 0.0018 18.4 0.1 1.7 1 1 0 1 1 1 1 RNA recognition motif DUF2315 PF10231.9 ETS62187.1 - 2e-21 76.4 2.7 3.7e-15 56.1 1.5 2.4 2 1 0 2 2 2 2 Apoptogenic protein 1 Death PF00531.22 ETS62187.1 - 0.065 13.4 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Death domain Nipped-B_C PF12830.7 ETS62188.1 - 6 6.8 7.3 17 5.3 0.0 3.7 4 0 0 4 4 4 0 Sister chromatid cohesion C-terminus DUF4345 PF14248.6 ETS62189.1 - 1.2e-10 41.3 0.4 2.3e-10 40.4 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4345) DUF1674 PF07896.12 ETS62191.1 - 5.6e-18 65.2 4.4 5.6e-18 65.2 4.4 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1674) AAA_11 PF13086.6 ETS62192.1 - 0.062 13.1 7.8 0.1 12.4 7.8 1.3 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 ETS62192.1 - 0.9 9.7 5.0 1.8 8.7 5.0 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family UPF0242 PF06785.11 ETS62192.1 - 8.9 6.4 8.6 14 5.7 8.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RQC PF09382.10 ETS62193.1 - 5.9e-24 84.1 0.3 1.4e-23 82.8 0.3 1.7 1 0 0 1 1 1 1 RQC domain DEAD PF00270.29 ETS62193.1 - 1.2e-19 70.8 0.0 2.3e-19 69.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS62193.1 - 1.4e-18 67.3 0.0 2.4e-17 63.3 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ETS62193.1 - 2.8e-16 60.0 6.4 1.2e-15 57.9 6.4 2.3 1 0 0 1 1 1 1 RecQ zinc-binding HRDC PF00570.23 ETS62193.1 - 6.7e-05 22.8 0.0 0.00014 21.8 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 ETS62193.1 - 0.0013 18.7 0.0 0.0029 17.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UME PF08064.13 ETS62193.1 - 0.046 13.6 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 UME (NUC010) domain Helicase_Sgs1 PF11408.8 ETS62193.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Sgs1 RecQ helicase Prenyltrans PF00432.21 ETS62194.1 - 5.5 6.8 6.8 4.4 7.1 0.1 2.4 2 0 0 2 2 2 0 Prenyltransferase and squalene oxidase repeat B56 PF01603.20 ETS62195.1 - 2.7e-194 645.9 9.4 3.3e-194 645.6 9.4 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) LamB_YcsF PF03746.16 ETS62196.1 - 5.6e-86 288.1 0.0 6.4e-86 287.9 0.0 1.0 1 0 0 1 1 1 1 LamB/YcsF family Cornichon PF03311.14 ETS62197.1 - 1.8e-52 176.8 14.1 2.1e-52 176.6 14.1 1.0 1 0 0 1 1 1 1 Cornichon protein MFS_1 PF07690.16 ETS62198.1 - 7.7e-11 41.5 19.2 2e-08 33.6 12.7 3.2 1 1 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETS62198.1 - 0.00071 18.2 0.5 0.00071 18.2 0.5 2.8 3 0 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 ETS62198.1 - 0.01 14.7 0.0 0.022 13.6 0.0 1.6 1 1 0 1 1 1 0 MFS_1 like family PrgI PF12666.7 ETS62198.1 - 0.26 12.0 1.4 1.2 9.9 0.1 2.6 2 0 0 2 2 2 0 PrgI family protein GTP_EFTU PF00009.27 ETS62199.1 - 1.7e-45 155.0 0.0 2.3e-45 154.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 ETS62199.1 - 2.3e-35 121.8 3.0 3.9e-35 121.1 3.0 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 ETS62199.1 - 1.1e-24 86.5 0.0 2.1e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ETS62199.1 - 2.2e-20 72.5 0.0 4.4e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 ETS62199.1 - 1.5e-06 28.3 0.0 2.9e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ETS62199.1 - 2.8e-05 24.4 0.1 5.5e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ETS62199.1 - 5.6e-05 23.2 0.0 0.00012 22.1 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 ETS62199.1 - 0.0011 18.6 0.0 0.0031 17.1 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETS62199.1 - 0.0014 18.8 0.0 0.0053 17.0 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ETS62199.1 - 0.004 17.2 0.1 2 8.4 0.0 2.3 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 ETS62199.1 - 0.0088 15.5 0.0 0.022 14.2 0.0 1.6 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 ETS62199.1 - 0.065 13.0 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF1770 PF08589.10 ETS62199.1 - 0.11 13.5 0.0 0.25 12.3 0.0 1.7 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1770) Glutaredoxin PF00462.24 ETS62200.1 - 7e-16 58.2 0.1 1e-15 57.7 0.1 1.2 1 0 0 1 1 1 1 Glutaredoxin bZIP_1 PF00170.21 ETS62201.1 - 0.00024 21.1 8.0 0.00045 20.3 8.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ETS62201.1 - 0.045 13.8 6.2 0.091 12.9 6.2 1.5 1 0 0 1 1 1 0 Basic region leucine zipper bZIP_Maf PF03131.17 ETS62201.1 - 0.056 14.0 8.1 0.085 13.4 4.8 2.9 3 0 0 3 3 3 0 bZIP Maf transcription factor Rotamase_2 PF13145.6 ETS62201.1 - 1.1 10.1 5.0 0.61 10.9 0.5 2.5 2 0 0 2 2 2 0 PPIC-type PPIASE domain Fasciclin PF02469.22 ETS62202.1 - 3.6e-23 82.2 0.1 3.6e-14 53.1 0.0 3.4 3 1 0 3 3 3 3 Fasciclin domain COesterase PF00135.28 ETS62203.1 - 1.8e-72 244.9 0.0 2.1e-70 238.1 0.0 2.6 1 1 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS62203.1 - 1.3e-06 28.4 4.0 0.0039 17.1 0.5 2.8 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 ETS62204.1 - 1.1e-06 28.5 0.1 1.1e-05 25.3 0.1 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS62204.1 - 1.3e-05 24.6 0.4 0.00074 18.8 0.1 2.6 1 1 0 3 3 3 1 Serine aminopeptidase, S33 DUF1749 PF08538.10 ETS62204.1 - 0.00029 20.0 0.0 0.00043 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Peptidase_S9 PF00326.21 ETS62204.1 - 0.00076 19.0 0.1 0.1 12.0 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family DUF915 PF06028.11 ETS62204.1 - 0.021 14.2 0.0 1.3 8.3 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) DUF2423 PF10338.9 ETS62205.1 - 1.4e-13 50.8 6.5 2.5e-13 50.0 6.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2423) Ank_2 PF12796.7 ETS62206.1 - 4.9e-43 145.6 0.9 8e-16 58.4 0.0 3.8 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS62206.1 - 3e-32 110.6 1.3 4.2e-10 40.0 0.0 5.0 3 1 1 4 4 4 4 Ankyrin repeats (many copies) SPX PF03105.19 ETS62206.1 - 5.5e-25 89.1 14.4 4.9e-09 36.6 0.8 3.4 1 1 2 3 3 3 3 SPX domain Ank_3 PF13606.6 ETS62206.1 - 1.6e-23 80.2 2.5 0.013 16.0 0.0 7.6 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 ETS62206.1 - 2.1e-21 75.3 7.2 0.0016 18.8 0.0 7.3 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 ETS62206.1 - 6.4e-21 74.2 4.4 0.0061 16.9 0.0 6.3 2 1 4 6 6 6 6 Ankyrin repeats (many copies) GDPD PF03009.17 ETS62206.1 - 9e-14 51.8 0.0 4e-13 49.7 0.0 2.1 2 1 0 2 2 2 1 Glycerophosphoryl diester phosphodiesterase family Peripla_BP_2 PF01497.18 ETS62206.1 - 0.04 13.5 0.0 0.089 12.3 0.0 1.5 1 0 0 1 1 1 0 Periplasmic binding protein CRM1_C PF08767.11 ETS62208.1 - 1e-130 435.6 1.3 8.8e-130 432.5 0.0 2.8 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 ETS62208.1 - 1.4e-40 138.8 0.7 1.4e-40 138.8 0.7 3.8 3 1 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 ETS62208.1 - 2.7e-34 116.6 4.2 6.2e-34 115.5 4.2 1.7 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 ETS62208.1 - 3.7e-31 107.0 0.8 1.5e-30 105.1 0.8 2.2 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 ETS62208.1 - 1.5e-20 72.4 0.9 4.5e-20 70.9 0.9 1.9 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 ETS62208.1 - 1.2e-15 57.2 0.7 6.2e-15 54.9 0.7 2.4 1 0 0 1 1 1 1 Importin-beta N-terminal domain WD40 PF00400.32 ETS62209.1 - 1.9e-19 69.7 22.7 2.1e-07 31.5 0.2 7.4 8 0 0 8 8 8 4 WD domain, G-beta repeat Fungal_trans PF04082.18 ETS62209.1 - 1.9e-12 46.8 0.0 3.4e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain ANAPC4_WD40 PF12894.7 ETS62209.1 - 7.6e-08 32.5 0.5 0.14 12.5 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain zf-C2H2 PF00096.26 ETS62209.1 - 0.00014 22.1 5.9 0.022 15.2 1.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type Ge1_WD40 PF16529.5 ETS62209.1 - 0.0057 15.7 0.1 1.7 7.5 0.0 2.8 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-C2H2_4 PF13894.6 ETS62209.1 - 0.011 16.5 7.1 0.12 13.3 0.5 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger CLTH PF10607.9 ETS62209.1 - 0.013 15.4 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Nucleoporin_C PF03177.14 ETS62210.1 - 3.9e-129 432.1 0.0 5.1e-129 431.7 0.0 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 ETS62210.1 - 1.4e-14 53.7 0.0 2.1e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like HTH_29 PF13551.6 ETS62210.1 - 0.057 13.4 0.7 0.58 10.2 0.0 3.1 3 0 0 3 3 3 0 Winged helix-turn helix AKAP_110 PF05716.13 ETS62212.1 - 0.16 10.2 0.0 0.19 9.9 0.0 1.0 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) DUF2786 PF10979.8 ETS62215.1 - 2.8e-12 46.3 0.4 2.8e-12 46.3 0.4 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2786) Guanylate_kin PF00625.21 ETS62216.1 - 8.2e-58 195.1 0.0 9.9e-58 194.8 0.0 1.1 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 ETS62216.1 - 7e-07 29.8 0.1 1.7e-06 28.5 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ETS62216.1 - 2.5e-05 24.8 0.0 0.00029 21.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETS62216.1 - 3.5e-05 24.1 0.0 0.00013 22.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ETS62216.1 - 0.0001 22.4 0.0 0.00033 20.7 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS62216.1 - 0.00017 21.6 0.0 0.00027 20.9 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_33 PF13671.6 ETS62216.1 - 0.00065 19.9 0.1 0.0084 16.3 0.0 2.5 1 1 1 2 2 2 1 AAA domain ABC_tran PF00005.27 ETS62216.1 - 0.0024 18.4 0.0 0.0034 17.9 0.0 1.6 1 1 0 1 1 1 1 ABC transporter NTPase_1 PF03266.15 ETS62216.1 - 0.0026 17.7 0.0 0.0041 17.0 0.0 1.5 1 0 0 1 1 1 1 NTPase NACHT PF05729.12 ETS62216.1 - 0.0028 17.6 0.0 0.01 15.7 0.0 1.9 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 ETS62216.1 - 0.0031 17.9 0.0 0.006 17.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 ETS62216.1 - 0.0042 17.1 0.0 0.008 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETS62216.1 - 0.0048 17.2 0.0 0.039 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETS62216.1 - 0.0063 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Rad17 PF03215.15 ETS62216.1 - 0.0076 16.2 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_29 PF13555.6 ETS62216.1 - 0.0076 16.0 0.1 0.017 14.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Thymidylate_kin PF02223.17 ETS62216.1 - 0.0096 15.6 0.0 0.058 13.1 0.0 1.9 1 1 0 1 1 1 1 Thymidylate kinase AAA_5 PF07728.14 ETS62216.1 - 0.01 15.8 0.0 0.16 12.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 ETS62216.1 - 0.011 15.0 0.1 0.081 12.1 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 ETS62216.1 - 0.011 15.7 0.0 0.083 12.8 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ETS62216.1 - 0.019 14.7 0.0 0.081 12.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ETS62216.1 - 0.02 15.3 0.0 0.05 14.0 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 ETS62216.1 - 0.035 13.3 0.0 0.042 13.1 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA_19 PF13245.6 ETS62216.1 - 0.036 14.4 0.1 3.7 7.9 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETS62216.1 - 0.041 13.6 0.0 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ETS62216.1 - 0.054 12.5 0.0 0.084 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RAP80_UIM PF18282.1 ETS62216.1 - 0.063 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif PCMT PF01135.19 ETS62217.1 - 8.9e-66 221.6 0.0 1e-65 221.4 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 ETS62217.1 - 1.7e-07 31.9 0.1 4.2e-07 30.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS62217.1 - 4e-07 29.9 0.0 5.9e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS62217.1 - 5.3e-05 23.8 0.0 0.0002 22.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ETS62217.1 - 0.00079 18.9 0.1 0.0011 18.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ETS62217.1 - 0.0014 18.5 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETS62217.1 - 0.004 17.1 0.0 0.0063 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS62217.1 - 0.022 14.3 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_18 PF12847.7 ETS62217.1 - 0.033 14.1 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ETS62217.1 - 0.088 13.6 0.0 0.17 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 ETS62217.1 - 0.095 11.6 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) UQ_con PF00179.26 ETS62218.1 - 7e-40 135.9 0.0 9.3e-40 135.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ETS62218.1 - 0.038 13.8 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 ETS62218.1 - 0.046 14.0 0.2 0.074 13.3 0.2 1.4 1 1 0 1 1 1 0 RWD domain Exo_endo_phos PF03372.23 ETS62219.1 - 2.7e-19 69.6 0.1 4e-19 69.1 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF5131 PF07505.11 ETS62219.1 - 0.17 11.4 0.0 0.94 8.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF5131) WD40 PF00400.32 ETS62220.1 - 6.1e-11 42.7 10.0 0.0018 19.0 0.1 5.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62220.1 - 4.2e-08 33.4 0.0 0.00056 20.2 0.0 3.0 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1356 PF07092.12 ETS62221.1 - 0.0017 17.7 0.8 0.003 16.9 0.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1356) LEA_2 PF03168.13 ETS62221.1 - 0.011 16.2 0.4 0.028 15.0 0.1 1.9 2 1 0 2 2 2 0 Late embryogenesis abundant protein Peptidase_S8 PF00082.22 ETS62222.1 - 5.8e-38 130.8 2.3 8.3e-38 130.3 2.3 1.2 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 ETS62222.1 - 3.3e-27 94.3 0.1 7.6e-27 93.2 0.1 1.7 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 ETS62222.1 - 0.19 12.5 8.9 1.2e+02 3.5 8.9 3.0 1 1 0 1 1 1 0 Peptidase S8 pro-domain Serglycin PF04360.12 ETS62222.1 - 5.3 7.0 5.7 13 5.8 5.7 1.5 1 0 0 1 1 1 0 Serglycin MIP PF00230.20 ETS62223.1 - 6.3e-45 153.6 13.5 8.9e-45 153.1 13.5 1.2 1 0 0 1 1 1 1 Major intrinsic protein Lactamase_B_6 PF16661.5 ETS62224.1 - 4.8e-48 163.2 0.0 2.5e-45 154.3 0.0 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 ETS62224.1 - 7.6e-35 120.6 0.2 4e-34 118.2 0.2 2.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 ETS62224.1 - 6.7e-18 65.0 0.0 3.6e-17 62.6 0.0 2.2 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 ETS62224.1 - 0.00033 20.5 0.0 0.00087 19.2 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ETS62224.1 - 0.0063 16.0 0.3 0.033 13.7 0.1 2.3 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Hepar_II_III PF07940.13 ETS62224.1 - 0.05 13.2 0.2 0.65 9.6 0.0 2.8 2 1 0 2 2 2 0 Heparinase II/III-like protein fn3_2 PF16893.5 ETS62225.1 - 4.2e-37 126.2 0.2 7.4e-37 125.4 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 ETS62225.1 - 5.6e-26 90.2 0.1 9e-26 89.6 0.1 1.3 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 ETS62225.1 - 0.00029 21.1 0.0 0.00054 20.3 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ETS62225.1 - 0.00034 20.5 0.1 0.0012 18.8 0.0 2.0 2 1 0 2 2 2 1 twin BRCT domain fn3 PF00041.21 ETS62225.1 - 0.0014 19.0 0.1 0.0041 17.4 0.1 1.8 1 1 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.8 ETS62225.1 - 0.0076 16.5 0.0 0.015 15.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 ETS62225.1 - 0.088 13.2 0.0 0.49 10.8 0.0 2.2 2 1 1 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain F-box PF00646.33 ETS62226.1 - 1.5e-07 31.1 0.3 2.7e-07 30.3 0.3 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETS62226.1 - 1.8e-07 30.9 0.8 3.4e-07 30.1 0.8 1.4 1 0 0 1 1 1 1 F-box-like Lactamase_B_3 PF13483.6 ETS62227.1 - 1.1e-06 28.6 0.0 6e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ETS62227.1 - 0.0022 17.5 0.9 0.0027 17.2 0.1 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain P34-Arc PF04045.14 ETS62228.1 - 6.7e-108 359.9 0.0 8.1e-108 359.6 0.0 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Thy1 PF02511.15 ETS62228.1 - 0.087 12.6 0.1 1.1 9.0 0.1 2.1 2 0 0 2 2 2 0 Thymidylate synthase complementing protein TFIIA PF03153.13 ETS62229.1 - 0.11 12.4 3.8 0.16 12.0 3.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYDLN_acid PF09538.10 ETS62229.1 - 2.9 8.6 10.0 1.1 9.9 6.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PGA2 PF07543.12 ETS62229.1 - 4.3 7.3 9.3 94 3.0 8.6 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 Macoilin PF09726.9 ETS62229.1 - 6.5 5.2 7.8 9.6 4.6 7.8 1.2 1 0 0 1 1 1 0 Macoilin family TEA PF01285.18 ETS62231.1 - 7.4e-30 102.8 0.0 1.9e-29 101.6 0.0 1.7 1 0 0 1 1 1 1 TEA/ATTS domain Pkinase_Tyr PF07714.17 ETS62232.1 - 2.9e-44 151.3 0.0 4e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETS62232.1 - 6.4e-42 143.7 0.0 9.4e-42 143.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETS62232.1 - 0.056 12.2 0.0 0.056 12.2 0.0 3.1 2 1 0 3 3 3 0 Fungal protein kinase Sec66 PF09802.9 ETS62233.1 - 1e-53 181.6 0.0 1.6e-53 181.0 0.0 1.2 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 Spt20 PF12090.8 ETS62233.1 - 8.8 5.9 10.4 14 5.2 10.4 1.2 1 0 0 1 1 1 0 Spt20 family RasGEF PF00617.19 ETS62234.1 - 4.2e-61 206.2 2.3 3e-60 203.5 0.1 2.8 3 0 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 ETS62234.1 - 4.8e-29 100.7 0.2 1.2e-28 99.4 0.2 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 ETS62234.1 - 6.2e-14 51.3 0.1 1.2e-13 50.4 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS62234.1 - 1.9e-10 40.4 0.1 3.9e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETS62234.1 - 2.5e-10 39.9 0.0 4.8e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Dynein_C PF18199.1 ETS62234.1 - 0.014 14.6 0.1 0.026 13.7 0.1 1.4 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain 5_3_exonuc PF01367.20 ETS62234.1 - 0.028 15.0 0.0 0.1 13.2 0.0 2.0 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold WW PF00397.26 ETS62234.1 - 0.18 11.9 0.2 0.44 10.7 0.2 1.6 1 0 0 1 1 1 0 WW domain SAE2 PF08573.10 ETS62235.1 - 1.1e-08 36.1 8.6 2.2e-07 32.0 0.2 3.3 2 1 1 3 3 3 3 DNA repair protein endonuclease SAE2/CtIP C-terminus UEV PF05743.13 ETS62236.1 - 2.6e-33 114.5 0.0 3.9e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 ETS62236.1 - 2.3e-28 97.9 1.7 5.4e-28 96.7 0.4 2.0 2 0 0 2 2 2 1 Vps23 core domain UQ_con PF00179.26 ETS62236.1 - 0.0044 16.7 0.0 0.0078 15.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme zf-Mss51 PF13824.6 ETS62237.1 - 2.1e-22 79.0 1.2 4.2e-22 78.0 1.2 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-NADH-PPase PF09297.11 ETS62237.1 - 0.22 11.2 1.3 13 5.5 0.3 2.5 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain GDP_Man_Dehyd PF16363.5 ETS62238.1 - 2.5e-49 168.5 0.0 5.9e-44 150.8 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETS62238.1 - 1.4e-45 155.6 0.0 2.2e-45 155.0 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS62238.1 - 2.3e-09 36.7 0.0 4.1e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ETS62238.1 - 2.3e-08 33.5 0.0 0.00012 21.4 0.0 2.4 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 ETS62238.1 - 5.6e-05 22.4 0.0 0.00014 21.0 0.0 1.7 2 0 0 2 2 2 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ETS62238.1 - 9e-05 21.7 0.1 0.0014 17.8 0.1 2.4 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 ETS62238.1 - 0.17 11.3 0.0 0.36 10.3 0.0 1.5 2 0 0 2 2 2 0 short chain dehydrogenase Lactamase_B_2 PF12706.7 ETS62239.1 - 1e-18 67.6 0.0 7.5e-18 64.8 0.0 2.3 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ETS62239.1 - 3.6e-06 27.0 0.0 1.4e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ETS62239.1 - 0.062 13.3 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Fungal_trans PF04082.18 ETS62240.1 - 5e-20 71.6 0.0 8.2e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS62240.1 - 2.3e-06 27.6 8.7 4.7e-06 26.6 8.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4188 PF13826.6 ETS62241.1 - 2.4e-24 85.9 0.0 3.6e-24 85.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) VirB3 PF05101.13 ETS62241.1 - 8.5 6.7 7.3 30 5.0 7.3 1.9 1 1 0 1 1 1 0 Type IV secretory pathway, VirB3-like protein ABC_tran_CTD PF16326.5 ETS62242.1 - 0.069 13.4 9.7 0.043 14.1 4.9 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain HAP1_N PF04849.13 ETS62242.1 - 1.1 8.4 11.2 0.42 9.8 0.5 2.8 3 0 0 3 3 3 0 HAP1 N-terminal conserved region Phage_GP20 PF06810.11 ETS62242.1 - 2.8 7.7 4.3 1.6 8.5 1.2 2.0 2 0 0 2 2 2 0 Phage minor structural protein GP20 DASH_Hsk3 PF08227.11 ETS62242.1 - 3.2 8.2 5.5 3.7 8.0 3.6 2.2 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like DUF724 PF05266.14 ETS62242.1 - 4.7 7.0 6.8 2.2 8.1 1.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 ETS62242.1 - 8 6.5 11.4 1.1 9.3 0.7 2.5 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CHORD PF04968.12 ETS62243.1 - 2.1e-42 143.6 13.3 6.3e-24 84.5 5.3 2.4 2 0 0 2 2 2 2 CHORD CS PF04969.16 ETS62243.1 - 1.5e-07 32.3 0.0 2.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 CS domain BTK PF00779.19 ETS62243.1 - 0.022 14.6 10.2 0.13 12.1 2.1 3.1 3 1 0 3 3 3 0 BTK motif AAA PF00004.29 ETS62244.1 - 5.3e-14 52.8 0.0 2.6e-13 50.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETS62244.1 - 0.00021 21.1 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_assoc_2 PF16193.5 ETS62244.1 - 0.00075 19.8 0.1 0.0024 18.2 0.1 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_14 PF13173.6 ETS62244.1 - 0.00078 19.5 0.0 0.0016 18.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETS62244.1 - 0.00097 19.6 0.0 0.13 12.6 0.0 3.3 3 1 1 4 4 4 1 AAA ATPase domain Rad17 PF03215.15 ETS62244.1 - 0.0019 18.1 0.1 0.076 12.9 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_25 PF13481.6 ETS62244.1 - 0.012 15.2 0.2 1.4 8.5 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 ETS62244.1 - 0.081 13.2 0.0 0.58 10.4 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.6 ETS62244.1 - 0.082 13.1 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETS62244.1 - 0.11 12.8 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETS62244.1 - 0.11 13.0 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ETS62244.1 - 0.13 11.5 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain ATPase PF06745.13 ETS62244.1 - 0.18 11.1 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.15 ETS62244.1 - 0.23 11.4 0.2 0.7 9.8 0.0 1.9 1 1 1 2 2 2 0 NTPase Carboxyl_trans PF01039.22 ETS62245.1 - 4.3e-139 464.3 0.2 5.4e-139 464.0 0.2 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ETS62245.1 - 0.013 15.0 0.1 0.62 9.5 0.0 2.2 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) SopD PF11047.8 ETS62245.1 - 0.19 10.9 0.0 0.28 10.3 0.0 1.2 1 0 0 1 1 1 0 Salmonella outer protein D AAA PF00004.29 ETS62246.1 - 9.1e-17 61.7 0.0 2.3e-16 60.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS62246.1 - 1.4e-05 25.3 1.5 0.0016 18.8 0.1 3.3 3 1 1 4 4 4 1 AAA domain AAA_5 PF07728.14 ETS62246.1 - 7.3e-05 22.8 0.1 0.00023 21.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETS62246.1 - 0.00019 21.8 0.2 0.00078 19.9 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 ETS62246.1 - 0.013 15.2 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_2 PF07724.14 ETS62246.1 - 0.014 15.5 0.0 0.038 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ETS62246.1 - 0.021 15.0 0.0 0.046 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ETS62246.1 - 0.026 13.9 0.1 0.057 12.8 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ETS62246.1 - 0.059 12.6 0.0 0.093 11.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 ETS62246.1 - 0.078 13.2 0.1 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETS62246.1 - 0.12 12.1 0.7 0.36 10.5 0.7 1.8 1 1 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ETS62246.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ETS62246.1 - 0.14 12.7 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ETS62246.1 - 0.53 10.6 2.3 0.43 10.9 0.2 2.0 2 1 0 2 2 2 0 AAA domain Na_Ca_ex PF01699.24 ETS62247.1 - 4.3e-13 49.5 13.8 6.2e-13 49.0 13.8 1.3 1 0 0 1 1 1 1 Sodium/calcium exchanger protein SLATT_5 PF18160.1 ETS62247.1 - 0.18 11.1 0.5 0.33 10.3 0.5 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 HNH_3 PF13392.6 ETS62248.1 - 6.6e-14 51.4 1.5 4.4e-07 29.5 0.4 2.5 2 0 0 2 2 2 2 HNH endonuclease Zn_clus PF00172.18 ETS62249.1 - 0.0016 18.5 8.6 0.0034 17.5 8.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peroxidase_2 PF01328.17 ETS62251.1 - 2.8e-40 138.8 0.0 4.2e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Peroxidase, family 2 DUF459 PF04311.13 ETS62251.1 - 0.057 12.4 0.0 0.084 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF459) Pro_isomerase PF00160.21 ETS62252.1 - 3.9e-51 173.4 0.0 1.5e-50 171.6 0.0 2.0 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 ETS62252.1 - 9.1e-05 23.2 0.2 0.26 12.2 0.2 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Mito_carr PF00153.27 ETS62253.1 - 8.6e-47 157.0 8.7 2.4e-17 62.7 0.1 4.4 3 1 0 3 3 3 3 Mitochondrial carrier protein CH PF00307.31 ETS62254.1 - 1.9e-47 159.9 0.1 9.7e-25 86.9 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 ETS62254.1 - 8.1e-21 73.9 0.0 2.2e-20 72.5 0.0 1.8 1 0 0 1 1 1 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 ETS62254.1 - 1.1e-10 41.2 0.0 5.6e-06 26.1 0.0 3.2 2 1 0 2 2 2 2 CAMSAP CH domain Spectrin PF00435.21 ETS62254.1 - 4.2e-06 27.2 5.3 0.0088 16.5 0.3 3.0 3 0 0 3 3 3 2 Spectrin repeat EF-hand_6 PF13405.6 ETS62254.1 - 8.3e-05 22.2 0.0 0.00037 20.2 0.0 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ETS62254.1 - 0.0061 16.0 0.0 0.022 14.3 0.0 2.0 2 0 0 2 2 2 1 EF hand Baculo_PEP_C PF04513.12 ETS62254.1 - 0.0097 15.9 0.3 0.055 13.5 0.2 2.3 1 1 1 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus CH_2 PF06294.11 ETS62254.1 - 0.015 15.4 0.0 4.9 7.3 0.0 3.1 3 0 0 3 3 3 0 CH-like domain in sperm protein DnaG_DnaB_bind PF08278.11 ETS62254.1 - 7.8 7.1 7.4 7.4 7.2 0.1 3.5 3 1 0 3 3 3 0 DNA primase DnaG DnaB-binding Cofilin_ADF PF00241.20 ETS62256.1 - 3.8e-43 146.1 0.5 4.3e-43 146.0 0.5 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Na_H_Exchanger PF00999.21 ETS62258.1 - 6.2e-52 176.7 40.5 8.7e-52 176.2 40.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family PP2C PF00481.21 ETS62259.1 - 3.4e-80 269.4 0.0 4.8e-80 268.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DUF4943 PF16301.5 ETS62260.1 - 0.088 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4943) WD40 PF00400.32 ETS62261.1 - 9.9e-21 73.7 0.0 8.5e-06 26.4 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62261.1 - 6.1e-07 29.6 0.0 0.5 10.7 0.0 5.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 ETS62261.1 - 0.0022 17.8 0.1 0.005 16.6 0.1 1.6 1 0 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain Nup160 PF11715.8 ETS62261.1 - 0.0046 15.7 0.4 0.07 11.8 0.3 2.1 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PH_5 PF15405.6 ETS62262.1 - 0.75 9.9 2.0 0.61 10.2 0.3 1.8 1 1 1 2 2 2 0 Pleckstrin homology domain PH_10 PF15411.6 ETS62263.1 - 4.7e-26 91.5 0.0 8.5e-26 90.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain zf-RING_UBOX PF13445.6 ETS62263.1 - 0.00015 21.7 0.4 0.00033 20.6 0.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETS62263.1 - 0.0012 19.1 1.8 0.002 18.4 0.5 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETS62263.1 - 0.0017 18.3 0.6 0.005 16.8 0.8 1.7 1 1 0 1 1 1 1 zinc-RING finger domain VWA PF00092.28 ETS62263.1 - 0.0032 17.8 0.0 0.026 14.8 0.0 2.4 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETS62263.1 - 0.005 16.8 0.1 0.2 11.6 0.0 2.8 3 0 0 3 3 3 1 von Willebrand factor type A domain zf-C3HC4 PF00097.25 ETS62263.1 - 0.022 14.6 0.2 0.047 13.6 0.2 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS62263.1 - 0.16 11.8 0.8 0.41 10.5 0.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETS62263.1 - 0.17 11.7 2.3 0.35 10.7 2.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger Ribonuc_red_lgC PF02867.15 ETS62265.1 - 7.8e-186 618.7 0.0 1e-185 618.3 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ETS62265.1 - 4e-25 87.6 0.0 1.2e-24 86.1 0.0 1.9 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 ETS62265.1 - 1.1e-17 64.4 0.2 4e-17 62.6 0.2 2.1 1 0 0 1 1 1 1 ATP cone domain Ufd2P_core PF10408.9 ETS62267.1 - 4.9e-201 669.6 0.0 5.8e-201 669.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 ETS62267.1 - 3.3e-28 97.6 0.2 9.3e-28 96.2 0.2 1.8 1 0 0 1 1 1 1 U-box domain CEP63 PF17045.5 ETS62267.1 - 0.28 11.0 2.7 0.93 9.3 0.0 2.3 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa BCNT PF07572.12 ETS62268.1 - 2e-18 66.2 0.5 2e-18 66.2 0.5 1.9 2 0 0 2 2 2 1 Bucentaur or craniofacial development DUF4505 PF14956.6 ETS62270.1 - 4.4e-28 98.2 0.0 8.3e-14 51.7 0.1 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4505) Yos1 PF08571.10 ETS62271.1 - 2.5e-30 104.5 1.0 4.2e-30 103.8 1.0 1.4 1 0 0 1 1 1 1 Yos1-like Ribosomal_S8 PF00410.19 ETS62271.1 - 1.7e-10 40.9 0.0 1.3e-09 38.1 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S8 DnaJ_C PF01556.18 ETS62272.1 - 6.1e-34 117.2 0.0 3.1e-32 111.7 0.0 2.1 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ETS62272.1 - 3.3e-25 88.0 2.0 4.6e-25 87.5 2.0 1.2 1 0 0 1 1 1 1 DnaJ domain RPT PF13446.6 ETS62272.1 - 0.011 15.7 0.1 0.017 15.0 0.1 1.2 1 0 0 1 1 1 0 A repeated domain in UCH-protein UDG PF03167.19 ETS62274.1 - 1.4e-13 51.2 0.0 3.1e-13 50.0 0.0 1.7 2 0 0 2 2 2 1 Uracil DNA glycosylase superfamily Arrestin_N PF00339.29 ETS62275.1 - 0.00011 22.3 0.0 0.00027 21.0 0.0 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ETS62275.1 - 0.023 14.4 0.0 0.45 10.2 0.0 2.2 2 0 0 2 2 2 0 Arrestin_N terminal like Aldedh PF00171.22 ETS62276.1 - 4.3e-157 523.3 0.1 5.3e-157 523.0 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETS62276.1 - 0.01 15.3 0.0 0.036 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) NDUFA12 PF05071.16 ETS62277.1 - 2.4e-31 108.4 2.1 3.6e-31 107.8 2.1 1.3 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 Flavokinase PF01687.17 ETS62279.1 - 6.5e-32 110.1 0.0 3.3e-31 107.9 0.0 1.8 1 1 0 1 1 1 1 Riboflavin kinase Rod_cone_degen PF15201.6 ETS62279.1 - 0.23 11.6 1.3 14 5.9 0.2 2.6 2 0 0 2 2 2 0 Progressive rod-cone degeneration RIC3 PF15361.6 ETS62280.1 - 0.63 10.4 0.0 0.63 10.4 0.0 3.0 3 1 1 4 4 4 0 Resistance to inhibitors of cholinesterase homologue 3 SAGA-Tad1 PF12767.7 ETS62280.1 - 9.7 5.8 9.2 8.8 6.0 0.1 3.1 3 0 0 3 3 3 0 Transcriptional regulator of RNA polII, SAGA, subunit CAP PF00188.26 ETS62281.1 - 4.4e-16 59.9 2.6 4.4e-16 59.9 2.6 2.5 3 1 0 3 3 3 1 Cysteine-rich secretory protein family MarB PF13999.6 ETS62281.1 - 0.046 13.6 0.1 4.3 7.3 0.0 2.7 2 0 0 2 2 2 0 MarB protein SOBP PF15279.6 ETS62281.1 - 2.2 8.8 17.0 3.7 8.1 17.0 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein XPG_I PF00867.18 ETS62282.1 - 2.2e-08 34.3 0.9 1.1e-07 32.0 0.1 2.6 2 1 0 2 2 2 1 XPG I-region XPG_N PF00752.17 ETS62282.1 - 3e-06 27.6 0.0 5.8e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ETS62282.1 - 4.2e-05 24.1 0.0 0.00012 22.6 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 ETS62282.1 - 0.0025 18.4 0.0 0.0093 16.6 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix domain Remorin_C PF03763.13 ETS62282.1 - 0.047 13.6 1.5 0.096 12.6 1.5 1.4 1 0 0 1 1 1 0 Remorin, C-terminal region HHH PF00633.23 ETS62282.1 - 0.074 13.0 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif POTRA_TamA_1 PF17243.2 ETS62282.1 - 0.1 12.7 1.3 0.84 9.8 0.1 2.7 1 1 0 2 2 2 0 POTRA domain TamA domain 1 V-ATPase_G PF03179.15 ETS62283.1 - 1.4e-34 118.8 14.9 1.9e-34 118.4 14.9 1.2 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit hDGE_amylase PF14701.6 ETS62283.1 - 0.019 14.1 1.5 0.025 13.7 1.5 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain ATP-synt_B PF00430.18 ETS62283.1 - 0.027 14.6 13.5 0.027 14.6 13.5 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Seryl_tRNA_N PF02403.22 ETS62283.1 - 0.1 12.9 12.4 0.22 11.8 12.0 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Ntox34 PF15606.6 ETS62283.1 - 0.19 11.9 0.6 0.61 10.2 0.6 1.8 1 0 0 1 1 1 0 Bacterial toxin 34 Rotamase_2 PF13145.6 ETS62283.1 - 0.53 11.1 7.2 0.93 10.3 7.2 1.3 1 0 0 1 1 1 0 PPIC-type PPIASE domain Symplekin_C PF12295.8 ETS62284.1 - 3.6e-60 203.3 2.8 4.8e-60 202.8 0.1 2.6 3 0 0 3 3 3 1 Symplekin tight junction protein C terminal DUF3453 PF11935.8 ETS62284.1 - 8.3e-55 185.9 1.6 2e-54 184.7 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) FbpA PF05833.11 ETS62284.1 - 0.039 12.7 0.1 0.069 11.9 0.1 1.3 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Adaptin_N PF01602.20 ETS62284.1 - 0.055 12.0 9.5 0.44 9.0 2.6 3.5 3 1 0 3 3 3 0 Adaptin N terminal region OPT PF03169.15 ETS62285.1 - 3.9e-170 567.5 53.9 4.4e-170 567.3 53.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein FAD_binding_3 PF01494.19 ETS62286.1 - 7.5e-87 291.8 0.0 1.1e-86 291.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 ETS62286.1 - 7.4e-50 169.2 0.1 1.4e-49 168.3 0.1 1.5 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain AlaDh_PNT_C PF01262.21 ETS62286.1 - 3.2e-05 23.3 0.0 6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 ETS62286.1 - 6.5e-05 21.8 0.1 0.00012 21.0 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 ETS62286.1 - 0.00046 19.4 2.2 0.0013 17.9 0.2 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein DAO PF01266.24 ETS62286.1 - 0.00065 19.4 0.2 0.0054 16.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS62286.1 - 0.001 18.4 0.1 0.0043 16.3 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS62286.1 - 0.0011 19.2 0.1 0.0025 18.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETS62286.1 - 0.0014 17.8 0.4 0.0028 16.8 0.4 1.4 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETS62286.1 - 0.0042 16.4 0.1 0.0077 15.5 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 ETS62286.1 - 0.039 12.8 0.1 0.06 12.2 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase FAD_oxidored PF12831.7 ETS62286.1 - 0.062 12.6 0.4 0.11 11.9 0.4 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS62286.1 - 0.078 12.2 0.3 0.13 11.5 0.3 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETS62286.1 - 0.11 11.6 0.2 0.18 10.9 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 ETS62286.1 - 0.14 12.8 0.1 0.31 11.6 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase His_Phos_2 PF00328.22 ETS62287.1 - 4.8e-42 144.7 0.0 6.7e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Sec7 PF01369.20 ETS62288.1 - 2.6e-70 235.9 0.0 5.6e-70 234.8 0.0 1.6 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ETS62288.1 - 5.6e-47 159.6 4.3 5.6e-47 159.6 4.3 4.1 4 1 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 ETS62288.1 - 1.6e-32 111.2 11.0 2.1e-32 110.8 0.1 5.7 7 0 0 7 7 7 1 Domain of unknown function (DUF1981) DCB PF16213.5 ETS62288.1 - 4.6e-21 75.3 0.6 4.6e-21 75.3 0.6 3.3 4 0 0 4 4 4 1 Dimerisation and cyclophilin-binding domain of Mon2 V-ATPase_H_N PF03224.14 ETS62288.1 - 0.14 11.4 0.9 6 6.1 0.0 3.1 3 1 0 3 3 3 0 V-ATPase subunit H Mob1_phocein PF03637.17 ETS62289.1 - 5e-77 257.7 0.1 5.9e-77 257.4 0.1 1.0 1 0 0 1 1 1 1 Mob1/phocein family E1-E2_ATPase PF00122.20 ETS62290.1 - 7.8e-38 129.8 1.3 7.8e-38 129.8 1.3 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETS62290.1 - 4.7e-16 59.0 8.9 4.7e-16 59.0 8.9 1.7 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETS62290.1 - 1.8e-15 57.8 4.1 1.5e-14 54.8 4.1 2.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ETS62290.1 - 1.8e-13 49.9 0.0 3.8e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ETS62290.1 - 1.8e-07 31.1 0.0 3.8e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETS62290.1 - 0.0017 18.1 0.1 0.0054 16.5 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETS62290.1 - 0.082 13.3 0.2 0.61 10.5 0.0 2.6 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase NAD4L PF06235.11 ETS62290.1 - 3.2 7.8 6.5 0.31 11.0 1.3 1.9 2 0 0 2 2 2 0 NADH dehydrogenase subunit 4L (NAD4L) Acyl_transf_3 PF01757.22 ETS62291.1 - 9.9e-13 47.9 36.8 1.8e-12 47.0 36.8 1.4 1 0 0 1 1 1 1 Acyltransferase family Glyco_hydro_16 PF00722.21 ETS62291.1 - 2.2e-07 30.5 0.0 3.7e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Sel1 PF08238.12 ETS62292.1 - 8.7e-19 67.6 29.8 0.00035 21.1 0.7 10.0 10 0 0 10 10 10 6 Sel1 repeat TPR_6 PF13174.6 ETS62292.1 - 0.36 11.6 7.2 47 4.9 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETS62292.1 - 0.83 10.0 0.0 0.83 10.0 0.0 5.2 8 0 0 8 8 8 0 Tetratricopeptide repeat DRIM PF07539.12 ETS62293.1 - 1.4e-169 565.4 12.0 2.4e-169 564.6 0.3 4.6 5 1 1 6 6 6 2 Down-regulated in metastasis DUF3385 PF11865.8 ETS62293.1 - 0.00019 21.4 0.4 0.2 11.6 0.0 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF3385) DUF3361 PF11841.8 ETS62293.1 - 0.035 14.0 0.2 0.21 11.5 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3361) Sec7_N PF12783.7 ETS62293.1 - 0.076 12.9 0.6 4.2 7.2 0.0 3.7 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ PF13513.6 ETS62293.1 - 2.4 8.8 13.5 1.6 9.3 0.9 6.1 5 0 0 5 5 5 0 HEAT-like repeat HEAT PF02985.22 ETS62293.1 - 5.6 7.5 8.4 1.3e+02 3.3 0.1 6.3 6 0 0 6 6 6 0 HEAT repeat Glyco_hydro_30 PF02055.16 ETS62294.1 - 1.7e-16 60.2 0.0 3.3e-16 59.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_59 PF02057.15 ETS62294.1 - 3e-10 39.8 0.2 1.3e-08 34.4 0.0 2.4 2 0 0 2 2 2 2 Glycosyl hydrolase family 59 AMP-binding PF00501.28 ETS62296.1 - 4.3e-76 256.2 0.0 5.7e-76 255.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS62296.1 - 1.5e-11 45.1 0.3 4.8e-11 43.5 0.3 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Kri1 PF05178.12 ETS62299.1 - 8.4e-30 103.4 10.5 8.4e-30 103.4 10.5 5.3 7 0 0 7 7 7 1 KRI1-like family Kri1_C PF12936.7 ETS62299.1 - 2.8e-25 88.3 0.1 2.8e-25 88.3 0.1 4.3 5 0 0 5 5 5 1 KRI1-like family C-terminal LIN52 PF10044.9 ETS62299.1 - 1.8 9.3 5.9 1 10.1 0.6 3.2 3 0 0 3 3 3 0 Retinal tissue protein p450 PF00067.22 ETS62300.1 - 5.5e-20 71.6 0.0 1.6e-19 70.0 0.0 1.7 1 1 0 1 1 1 1 Cytochrome P450 DUF2428 PF10350.9 ETS62300.1 - 0.058 12.6 0.0 0.088 12.1 0.0 1.2 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) GTP1_OBG PF01018.22 ETS62301.1 - 1.7e-39 134.9 1.1 1.8e-28 99.1 0.9 2.5 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 ETS62301.1 - 4e-19 68.8 0.0 8.4e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RRM_1 PF00076.22 ETS62301.1 - 1e-05 25.2 0.0 3.9e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FeoB_N PF02421.18 ETS62301.1 - 9.8e-05 21.9 0.1 0.00025 20.6 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 ETS62301.1 - 0.012 15.2 0.0 0.18 11.3 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MeaB PF03308.16 ETS62301.1 - 0.02 13.9 0.9 1.2 8.0 0.0 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 ETS62301.1 - 0.12 12.9 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Arf PF00025.21 ETS62301.1 - 0.18 11.2 0.0 0.69 9.3 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETS62301.1 - 0.19 11.1 0.0 0.34 10.2 0.0 1.4 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Cellulase PF00150.18 ETS62302.1 - 2.3e-10 40.4 0.2 2.3e-10 40.4 0.2 1.7 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) RCC1 PF00415.18 ETS62303.1 - 9.4e-47 157.4 6.2 2.2e-11 44.2 0.0 6.2 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETS62303.1 - 4.1e-23 80.6 22.3 1.3e-06 28.0 0.8 5.8 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat PHD PF00628.29 ETS62303.1 - 9.5e-11 41.4 7.0 2.3e-10 40.2 7.0 1.7 1 0 0 1 1 1 1 PHD-finger zf-UDP PF14569.6 ETS62303.1 - 0.00061 19.9 1.6 0.0018 18.3 1.6 1.7 1 0 0 1 1 1 1 Zinc-binding RING-finger PHD_4 PF16866.5 ETS62303.1 - 0.0068 16.5 10.4 0.015 15.4 10.4 1.6 1 0 0 1 1 1 1 PHD-finger Kelch_6 PF13964.6 ETS62303.1 - 0.11 12.8 4.0 17 5.9 0.2 4.1 4 0 0 4 4 4 0 Kelch motif zf-RING-like PF08746.11 ETS62303.1 - 0.64 10.4 4.2 1.9 8.9 4.2 1.8 1 0 0 1 1 1 0 RING-like domain PHD_2 PF13831.6 ETS62303.1 - 1.2 8.8 6.3 0.37 10.4 3.3 1.8 2 0 0 2 2 2 0 PHD-finger OrfB_Zn_ribbon PF07282.11 ETS62303.1 - 2.3 8.2 4.7 4.9 7.2 0.4 3.0 4 0 0 4 4 4 0 Putative transposase DNA-binding domain Glyco_tranf_2_3 PF13641.6 ETS62304.1 - 1.8e-11 44.4 0.0 3.8e-11 43.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ETS62304.1 - 3e-10 40.4 1.4 5.6e-10 39.5 1.4 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ETS62304.1 - 5.7e-05 23.0 0.0 0.00012 22.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ETS62304.1 - 0.00029 20.4 0.0 0.00076 19.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 21 Transp_cyt_pur PF02133.15 ETS62306.1 - 2.2e-91 306.9 35.0 2.6e-91 306.6 35.0 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MadM PF03818.13 ETS62306.1 - 0.026 14.4 4.5 0.88 9.5 0.5 3.7 3 0 0 3 3 3 0 Malonate/sodium symporter MadM subunit Peptidase_M28 PF04389.17 ETS62307.1 - 1.7e-33 116.0 0.0 2.7e-33 115.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Na_Pi_cotrans PF02690.15 ETS62307.1 - 0.53 10.4 9.5 0.5 10.5 7.9 1.8 1 1 0 1 1 1 0 Na+/Pi-cotransporter PrmA PF06325.13 ETS62308.1 - 1.8e-12 47.3 0.0 3.1e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ETS62308.1 - 1.5e-10 41.7 0.0 4.7e-10 40.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS62308.1 - 2.2e-10 40.5 0.0 5.2e-10 39.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS62308.1 - 9.7e-07 28.5 0.0 1.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 ETS62308.1 - 6.2e-06 26.8 0.0 1.7e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETS62308.1 - 1e-05 25.0 0.0 1.8e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ETS62308.1 - 1.3e-05 25.1 0.0 4.4e-05 23.4 0.0 1.9 3 0 0 3 3 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 ETS62308.1 - 5e-05 23.1 0.0 8.1e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 ETS62308.1 - 8e-05 23.3 0.0 0.00046 20.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 ETS62308.1 - 0.0001 22.2 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 ETS62308.1 - 0.00053 21.0 0.9 0.0022 19.0 0.0 2.5 3 1 1 4 4 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ETS62308.1 - 0.0016 18.1 0.0 0.0043 16.7 0.0 1.7 2 0 0 2 2 2 1 Conserved hypothetical protein 95 PCMT PF01135.19 ETS62308.1 - 0.0017 18.2 0.0 0.0032 17.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_9 PF08003.11 ETS62308.1 - 0.0033 16.4 0.0 0.0094 14.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) Pox_A_type_inc PF04508.12 ETS62308.1 - 0.012 15.4 3.2 0.054 13.4 0.3 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Methyltransf_32 PF13679.6 ETS62308.1 - 0.018 15.0 0.0 0.047 13.7 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain PKcGMP_CC PF16808.5 ETS62308.1 - 0.028 14.3 0.8 0.062 13.2 0.8 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FtsJ PF01728.19 ETS62308.1 - 0.036 14.2 0.1 0.17 12.0 0.0 2.1 2 0 0 2 2 2 0 FtsJ-like methyltransferase HIRA_B PF09453.10 ETS62308.1 - 0.041 13.7 0.1 0.086 12.7 0.1 1.5 1 0 0 1 1 1 0 HIRA B motif Met_10 PF02475.16 ETS62308.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein PRMT5 PF05185.16 ETS62308.1 - 0.14 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase SQS_PSY PF00494.19 ETS62309.1 - 7.2e-31 107.6 0.0 1.4e-30 106.7 0.0 1.4 1 0 0 1 1 1 1 Squalene/phytoene synthase Prenyltrans PF00432.21 ETS62310.1 - 7.6e-35 118.3 12.2 7.1e-11 41.7 0.5 7.0 6 2 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ETS62310.1 - 0.003 16.7 0.0 0.46 9.5 0.0 2.6 2 1 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 ETS62310.1 - 0.013 14.6 0.0 0.46 9.5 0.0 3.0 2 1 2 4 4 4 0 A-macroglobulin TED domain SQHop_cyclase_N PF13249.6 ETS62310.1 - 0.054 12.6 0.0 14 4.6 0.0 3.2 2 1 1 3 3 3 0 Squalene-hopene cyclase N-terminal domain AAA_9 PF12781.7 ETS62312.1 - 1.3e-73 246.8 0.2 1.3e-73 246.8 0.2 3.4 3 0 0 3 3 3 1 ATP-binding dynein motor region MT PF12777.7 ETS62312.1 - 1.5e-48 165.6 6.3 3.4e-48 164.4 6.3 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_C PF18199.1 ETS62312.1 - 7.5e-37 127.2 1.1 1.3e-36 126.4 0.0 1.9 2 0 0 2 2 2 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETS62312.1 - 6.7e-32 110.6 0.0 1.3e-31 109.6 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ETS62312.1 - 9.6e-29 99.9 0.0 6.5e-28 97.2 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_8 PF12780.7 ETS62312.1 - 0.0003 20.2 0.1 0.00086 18.7 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Spc7 PF08317.11 ETS62312.1 - 0.074 11.9 31.1 0.018 14.0 11.4 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein DUF4250 PF14056.6 ETS62312.1 - 0.092 12.7 1.4 11 6.0 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Seryl_tRNA_N PF02403.22 ETS62312.1 - 0.87 9.8 21.2 0.19 12.0 1.2 3.7 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 ETS62312.1 - 0.9 10.1 30.5 0.16 12.5 1.1 3.6 3 0 0 3 3 3 0 Apg6 coiled-coil region Atg14 PF10186.9 ETS62312.1 - 0.94 8.5 16.5 0.9 8.6 8.1 2.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phlebovirus_NSM PF07246.11 ETS62312.1 - 1.3 8.3 9.2 0.6 9.4 0.1 2.5 2 0 0 2 2 2 0 Phlebovirus nonstructural protein NS-M Phage_GP20 PF06810.11 ETS62312.1 - 1.8 8.4 23.3 1 9.1 0.1 3.8 3 1 0 3 3 3 0 Phage minor structural protein GP20 ZapB PF06005.12 ETS62312.1 - 2.2 8.8 30.1 1.2 9.7 2.1 5.2 4 1 0 4 4 4 0 Cell division protein ZapB HMMR_N PF15905.5 ETS62312.1 - 2.6 7.4 28.1 0.12 11.8 2.7 2.9 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal Jnk-SapK_ap_N PF09744.9 ETS62312.1 - 2.7 8.2 27.6 0.4 10.9 2.4 3.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF812 PF05667.11 ETS62312.1 - 2.8 6.7 21.4 0.43 9.4 2.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF812) DUF4407 PF14362.6 ETS62312.1 - 3.8 6.8 18.5 16 4.7 12.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 ETS62312.1 - 9.6 6.5 18.0 4.7 7.5 0.3 4.4 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) eIF2A PF08662.11 ETS62313.1 - 1.8e-82 275.9 0.1 2.6e-81 272.2 0.0 2.4 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ETS62313.1 - 0.00023 21.9 2.6 14 6.7 0.1 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat TauD PF02668.16 ETS62314.1 - 7.7e-27 94.8 0.2 1.1e-26 94.3 0.2 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Amidohydro_2 PF04909.14 ETS62315.1 - 2.6e-23 83.2 0.7 1e-22 81.3 0.7 1.9 1 1 0 1 1 1 1 Amidohydrolase APG9 PF04109.16 ETS62316.1 - 5.7e-205 681.8 2.0 7e-205 681.6 2.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 DIOX_N PF14226.6 ETS62316.1 - 7.4e-26 91.2 0.1 1.8e-25 90.0 0.1 1.7 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETS62316.1 - 4.3e-16 59.2 0.0 1.1e-15 58.0 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF2231 PF09990.9 ETS62316.1 - 0.015 15.7 1.0 0.015 15.7 1.0 2.8 2 1 1 3 3 3 0 Predicted membrane protein (DUF2231) CPSase_L_D2 PF02786.17 ETS62317.1 - 1.4e-74 250.1 0.0 2.3e-74 249.4 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ETS62317.1 - 1.2e-43 148.1 1.6 1.5e-43 147.8 0.1 2.0 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ETS62317.1 - 1.6e-34 118.3 0.0 5.5e-32 110.1 0.0 2.5 1 1 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ETS62317.1 - 2.6e-11 43.2 0.1 5.7e-11 42.1 0.1 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ETS62317.1 - 8.1e-10 38.6 0.0 1.6e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ETS62317.1 - 4.3e-07 29.7 0.0 1.2e-06 28.2 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ETS62317.1 - 8.6e-06 25.5 0.0 3.4e-05 23.6 0.0 2.0 1 0 0 1 1 1 1 Biotin-lipoyl like GARS_A PF01071.19 ETS62317.1 - 0.00054 19.8 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.14 ETS62317.1 - 0.0015 18.6 0.0 0.0034 17.5 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 ETS62317.1 - 0.053 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain EMP24_GP25L PF01105.24 ETS62318.1 - 1.7e-44 151.9 0.0 2e-44 151.7 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD NuA4 PF09340.10 ETS62319.1 - 8.2e-23 80.1 0.1 8.2e-23 80.1 0.1 1.8 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 Vfa1 PF08432.10 ETS62319.1 - 0.55 10.5 11.0 1 9.7 11.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SRP-alpha_N PF04086.13 ETS62319.1 - 7.2 6.4 18.7 11 5.8 18.7 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MAP65_ASE1 PF03999.12 ETS62322.1 - 8.2 5.0 5.4 13 4.3 5.4 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) ER_lumen_recept PF00810.18 ETS62323.1 - 5e-56 189.6 7.4 6.1e-56 189.3 7.4 1.1 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 ETS62323.1 - 4.4e-05 23.2 4.7 0.42 10.4 0.0 3.9 3 1 1 4 4 4 2 PQ loop repeat RRM_1 PF00076.22 ETS62324.1 - 1.5e-06 27.9 0.1 3.9e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FHA PF00498.26 ETS62325.1 - 1.4e-14 54.1 0.0 1.4e-14 54.1 0.0 2.8 4 0 0 4 4 4 1 FHA domain Lipoprotein_7 PF01540.16 ETS62325.1 - 0.00056 19.3 0.8 0.1 11.8 0.2 2.1 2 0 0 2 2 2 2 Adhesin lipoprotein Yop-YscD_cpl PF16697.5 ETS62325.1 - 0.0018 18.5 0.0 0.0085 16.4 0.0 2.1 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF812 PF05667.11 ETS62325.1 - 0.0019 17.2 23.7 0.012 14.6 11.7 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF812) DUF1664 PF07889.12 ETS62325.1 - 0.18 11.8 20.5 0.06 13.4 2.8 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF1664) Tweety PF04906.13 ETS62325.1 - 0.64 8.6 6.7 0.39 9.3 0.6 2.2 2 0 0 2 2 2 0 Tweety DUF2721 PF11026.8 ETS62325.1 - 5.4 6.9 5.5 36 4.2 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) SARAF PF06682.12 ETS62325.1 - 6.3 6.3 11.4 1.6 8.3 0.9 2.6 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis ATG16 PF08614.11 ETS62325.1 - 7.7 6.7 52.9 1.1 9.4 20.4 4.0 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 ETS62325.1 - 8.6 6.7 8.4 11 6.3 2.3 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FAM184 PF15665.5 ETS62325.1 - 8.9 6.0 37.7 2.4 7.9 13.9 2.5 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B BRO1 PF03097.18 ETS62328.1 - 4.8e-15 55.3 0.0 8.9e-15 54.4 0.0 1.3 1 0 0 1 1 1 1 BRO1-like domain MscS_porin PF12795.7 ETS62329.1 - 0.0004 20.0 19.9 0.0004 20.0 19.9 7.7 2 1 3 7 7 7 3 Mechanosensitive ion channel porin domain APG6_N PF17675.1 ETS62329.1 - 0.0026 18.3 0.4 0.0026 18.3 0.4 8.9 2 1 4 8 8 8 2 Apg6 coiled-coil region BST2 PF16716.5 ETS62329.1 - 0.017 15.7 9.6 0.017 15.7 9.6 9.8 4 3 7 12 12 12 0 Bone marrow stromal antigen 2 PhoLip_ATPase_C PF16212.5 ETS62330.1 - 9.2e-74 248.3 21.4 1.7e-73 247.5 21.4 1.4 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ETS62330.1 - 1.1e-27 95.6 1.5 2.5e-27 94.4 1.5 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ETS62330.1 - 2.1e-12 46.9 0.0 6.9e-12 45.3 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETS62330.1 - 1.1e-11 45.4 1.7 3.1e-07 30.9 0.3 3.3 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ETS62330.1 - 0.00022 20.8 0.0 0.0009 18.8 0.0 2.1 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ETS62330.1 - 0.0037 17.1 0.2 0.022 14.5 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Pinin_SDK_memA PF04696.13 ETS62331.1 - 1.2e-13 51.3 7.2 2.4e-13 50.3 7.2 1.6 1 0 0 1 1 1 1 pinin/SDK/memA/ protein conserved region Cue1_U7BR PF18499.1 ETS62331.1 - 0.044 13.8 1.1 0.094 12.8 1.1 1.5 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 vWA-TerF-like PF10138.9 ETS62332.1 - 1.4e-08 35.1 0.0 2.2e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 vWA found in TerF C terminus VWA PF00092.28 ETS62332.1 - 0.005 17.1 0.0 0.048 13.9 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETS62332.1 - 0.062 14.0 0.0 0.2 12.3 0.0 2.0 1 1 0 1 1 1 0 von Willebrand factor type A domain Methyltransf_34 PF11312.8 ETS62332.1 - 0.062 12.5 0.0 0.09 12.0 0.0 1.2 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase HEAT_EZ PF13513.6 ETS62333.1 - 7.4e-33 112.6 26.1 1.4e-13 51.0 0.0 10.7 11 2 2 13 13 11 6 HEAT-like repeat HEAT PF02985.22 ETS62333.1 - 5.5e-20 69.7 12.8 0.0018 18.4 0.0 9.7 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 ETS62333.1 - 2e-14 53.7 0.7 0.00026 21.3 0.0 7.2 5 3 3 8 8 8 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ETS62333.1 - 2.3e-10 40.9 0.0 0.00045 20.8 0.1 4.1 2 2 1 3 3 3 3 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 ETS62333.1 - 8.2e-07 28.9 0.0 3.1e-06 27.0 0.0 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cnd1 PF12717.7 ETS62333.1 - 3.6e-06 27.1 0.0 0.43 10.6 0.0 4.0 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ETS62333.1 - 0.0015 18.5 3.8 1.4 9.1 0.0 5.1 6 0 0 6 6 5 1 Armadillo/beta-catenin-like repeat MMS19_C PF12460.8 ETS62333.1 - 0.0021 17.2 2.3 6.3 5.8 0.0 4.0 5 0 0 5 5 5 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 ETS62333.1 - 0.0045 16.6 0.0 13 5.2 0.0 4.7 4 1 1 5 5 5 0 CLASP N terminal Cnd3 PF12719.7 ETS62333.1 - 0.013 14.7 0.2 4.1 6.5 0.1 3.4 2 1 1 3 3 3 0 Nuclear condensing complex subunits, C-term domain DUF3437 PF11919.8 ETS62333.1 - 0.028 14.3 0.0 5.7 6.9 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) Ecm29 PF13001.7 ETS62333.1 - 0.037 12.7 0.0 23 3.5 0.0 3.7 3 1 0 4 4 4 0 Proteasome stabiliser UNC45-central PF11701.8 ETS62333.1 - 0.079 12.9 0.0 0.57 10.1 0.0 2.4 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central TIP120 PF08623.10 ETS62333.1 - 0.11 12.2 0.1 8.1 6.2 0.1 3.3 4 0 0 4 4 4 0 TATA-binding protein interacting (TIP20) CENP-B_dimeris PF09026.10 ETS62333.1 - 0.12 12.7 9.1 0.37 11.2 9.1 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RNA_pol_3_Rpc31 PF11705.8 ETS62333.1 - 3.9 7.7 7.3 6.1 7.0 7.3 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Peptidase_S8 PF00082.22 ETS62334.1 - 4.8e-33 114.7 9.3 9.7e-33 113.7 9.3 1.5 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ETS62334.1 - 1.8e-10 41.3 0.0 3.2e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase inhibitor I9 Cpn60_TCP1 PF00118.24 ETS62335.1 - 1e-153 512.6 0.4 1.1e-153 512.4 0.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TetR_C_14 PF17754.1 ETS62335.1 - 0.086 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 MftR C-terminal domain GIDA PF01134.22 ETS62336.1 - 8.8e-131 436.6 0.0 1.4e-130 435.9 0.0 1.3 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 ETS62336.1 - 3.3e-57 194.1 0.0 4.6e-57 193.6 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 ETS62336.1 - 1.8e-08 34.0 0.0 4.5e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ETS62336.1 - 1.9e-06 27.5 0.5 2.8e-06 26.9 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETS62336.1 - 0.00036 19.7 2.4 0.00093 18.4 2.4 1.7 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ETS62336.1 - 0.0033 16.2 1.9 0.076 11.7 0.6 2.7 3 0 0 3 3 3 1 HI0933-like protein Lycopene_cycl PF05834.12 ETS62336.1 - 0.019 14.1 0.6 0.5 9.4 0.4 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox_3 PF13738.6 ETS62336.1 - 0.021 14.1 0.1 0.26 10.5 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ETS62336.1 - 0.05 12.9 0.2 0.088 12.1 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ETS62336.1 - 0.13 11.5 0.3 0.23 10.7 0.3 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 ETS62336.1 - 0.18 12.4 0.7 0.43 11.2 0.7 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PH PF00169.29 ETS62337.1 - 0.00037 21.0 0.0 0.0043 17.5 0.0 2.4 1 1 0 1 1 1 1 PH domain SLD3 PF08639.10 ETS62338.1 - 5.6e-11 41.9 0.5 8.2e-11 41.4 0.5 1.2 1 0 0 1 1 1 1 DNA replication regulator SLD3 Glyco_hydro_31 PF01055.26 ETS62339.1 - 4e-127 425.1 1.1 8.3e-127 424.0 1.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ETS62339.1 - 7e-21 74.3 0.3 1.6e-19 70.0 0.1 2.7 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 ETS62339.1 - 2.1e-06 27.9 0.0 5.3e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) TP_methylase PF00590.20 ETS62340.1 - 9.3e-19 68.2 0.4 2.1e-18 67.1 0.0 1.8 2 1 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sad1_UNC PF07738.13 ETS62341.1 - 7.3e-25 87.5 0.0 1.2e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal MFS_1 PF07690.16 ETS62343.1 - 7.2e-13 48.2 50.7 1.1e-10 41.0 50.7 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Myb_Cef PF11831.8 ETS62344.1 - 8.4e-58 195.7 5.1 8.4e-58 195.7 5.1 3.1 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 ETS62344.1 - 3.7e-23 81.5 5.7 2.9e-11 43.4 0.9 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETS62344.1 - 3.8e-19 68.7 6.8 4.7e-13 49.2 2.7 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain HCV_NS4b PF01001.19 ETS62344.1 - 0.072 12.7 0.1 0.12 11.9 0.1 1.2 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS4b bZIP_1 PF00170.21 ETS62345.1 - 3.1e-06 27.2 0.8 8.8e-06 25.7 0.8 1.7 1 0 0 1 1 1 1 bZIP transcription factor CRF1 PF10380.9 ETS62345.1 - 0.0068 16.7 0.1 0.023 15.0 0.1 1.9 1 0 0 1 1 1 1 Transcription factor CRF1 ATG16 PF08614.11 ETS62345.1 - 0.02 15.2 0.5 0.02 15.2 0.5 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Macoilin PF09726.9 ETS62345.1 - 0.13 10.8 0.6 0.24 9.9 0.6 1.3 1 0 0 1 1 1 0 Macoilin family Cep57_CLD PF14073.6 ETS62345.1 - 7.4 6.5 6.5 0.61 10.1 0.1 2.2 3 0 0 3 3 3 0 Centrosome localisation domain of Cep57 Uso1_p115_head PF04869.14 ETS62346.1 - 1.5e-56 191.8 0.0 1.8e-52 178.4 0.0 3.9 3 1 0 3 3 3 2 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 ETS62346.1 - 4.9e-09 36.6 41.6 4.9e-09 36.6 41.6 8.7 3 1 4 7 7 7 1 Uso1 / p115 like vesicle tethering protein, C terminal region Arm_vescicular PF18770.1 ETS62346.1 - 0.00038 20.3 0.0 0.00088 19.2 0.0 1.6 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor Atx10homo_assoc PF09759.9 ETS62346.1 - 0.071 13.1 6.5 0.44 10.6 0.0 5.2 6 0 0 6 6 6 0 Spinocerebellar ataxia type 10 protein domain Spo12 PF05032.12 ETS62347.1 - 2.5e-10 40.1 0.8 5.5e-10 39.0 0.8 1.6 1 0 0 1 1 1 1 Spo12 family EcKinase PF02958.20 ETS62348.1 - 2.6e-19 69.6 0.0 1.9e-18 66.8 0.0 1.9 1 1 0 1 1 1 1 Ecdysteroid kinase APH PF01636.23 ETS62348.1 - 2.5e-12 47.2 2.0 4.3e-12 46.5 2.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF1679 PF07914.11 ETS62348.1 - 2.8e-08 33.0 0.0 4.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) POB3_N PF17292.2 ETS62349.1 - 1.9e-27 95.5 0.0 4.4e-24 84.7 0.0 2.4 2 0 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 ETS62349.1 - 9e-24 83.2 0.0 3.4e-23 81.3 0.0 2.0 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 ETS62349.1 - 8.6e-23 80.6 0.0 1.7e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DUF3780 PF12635.7 ETS62349.1 - 0.13 12.1 0.1 0.25 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3780) THOC2_N PF16134.5 ETS62349.1 - 0.93 8.0 3.4 1.6 7.3 3.4 1.3 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus TFIIA PF03153.13 ETS62349.1 - 3.9 7.4 9.8 0.33 10.9 3.6 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 ETS62349.1 - 6.1 6.1 16.6 1 8.6 10.6 2.0 2 0 0 2 2 2 0 BUD22 DUF1899 PF08953.11 ETS62350.1 - 2.3e-31 107.5 0.6 4.9e-31 106.4 0.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 ETS62350.1 - 1e-17 63.8 1.5 1.4e-16 60.1 0.4 2.4 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 ETS62350.1 - 5.8e-09 36.5 7.4 0.011 16.6 0.1 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62350.1 - 1.5e-05 25.2 0.0 1.8 9.0 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PspA_IM30 PF04012.12 ETS62350.1 - 0.00059 19.5 0.8 0.00099 18.7 0.8 1.3 1 0 0 1 1 1 1 PspA/IM30 family ZapB PF06005.12 ETS62350.1 - 0.21 12.0 4.1 0.47 10.9 4.1 1.5 1 0 0 1 1 1 0 Cell division protein ZapB CRAL_TRIO PF00650.20 ETS62351.1 - 6.7e-30 103.9 0.0 1.1e-29 103.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ETS62351.1 - 4.4e-09 36.4 0.5 1.3e-08 34.8 0.5 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ETS62351.1 - 6.5e-08 32.8 0.0 1.2e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CCDC24 PF15669.5 ETS62351.1 - 0.082 12.8 3.9 0.066 13.1 0.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family GARP PF16731.5 ETS62351.1 - 4.8 6.8 12.9 1.9 8.2 1.6 2.5 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Zn_clus PF00172.18 ETS62352.1 - 7.6e-08 32.4 7.3 1.3e-07 31.6 7.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ceramidase PF05875.12 ETS62353.1 - 5.9e-83 278.3 7.8 7.2e-83 278.0 7.8 1.0 1 0 0 1 1 1 1 Ceramidase DUF3985 PF13153.6 ETS62353.1 - 0.044 13.8 0.0 0.25 11.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3985) Glyco_hydro_10 PF00331.20 ETS62354.1 - 5.3e-51 173.7 0.0 6.4e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 10 TrkH PF02386.16 ETS62355.1 - 3.8e-102 342.3 4.8 2.1e-98 330.0 2.6 2.1 2 0 0 2 2 2 2 Cation transport protein Ion_trans_2 PF07885.16 ETS62355.1 - 0.2 11.6 5.0 0.97 9.4 5.0 2.2 1 0 0 1 1 1 0 Ion channel UPF0016 PF01169.19 ETS62356.1 - 4.7e-41 139.0 27.4 1.7e-21 76.3 9.0 2.5 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 TerC PF03741.16 ETS62356.1 - 1.4 8.5 10.1 0.23 11.1 3.2 2.3 2 0 0 2 2 2 0 Integral membrane protein TerC family Sacchrp_dh_NADP PF03435.18 ETS62357.1 - 5.5e-16 59.0 0.0 8.2e-16 58.5 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DapB_N PF01113.20 ETS62357.1 - 0.00061 19.9 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 ETS62357.1 - 0.0033 17.3 0.0 0.0063 16.4 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Semialdhyde_dh PF01118.24 ETS62357.1 - 0.0049 17.3 0.0 0.02 15.3 0.0 2.0 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 ETS62357.1 - 0.022 14.2 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Frataxin_Cyay PF01491.16 ETS62359.1 - 3.4e-39 133.3 0.0 5.3e-39 132.6 0.0 1.3 1 0 0 1 1 1 1 Frataxin-like domain Aminotran_1_2 PF00155.21 ETS62360.1 - 8.2e-58 196.3 0.0 1.1e-57 195.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Esterase PF00756.20 ETS62360.1 - 2.6e-48 164.8 0.0 3.6e-48 164.4 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ETS62360.1 - 0.0048 16.2 0.0 0.0082 15.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETS62360.1 - 0.0099 15.4 0.0 0.018 14.5 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 ETS62360.1 - 0.031 13.2 0.0 0.071 12.0 0.0 1.5 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 ETS62360.1 - 0.093 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Phage_fiber_2 PF03406.13 ETS62361.1 - 0.045 13.3 1.8 0.058 13.0 1.0 1.6 1 1 0 1 1 1 0 Phage tail fibre repeat MIF4G PF02854.19 ETS62362.1 - 5.7e-59 199.3 1.0 8.5e-59 198.7 1.0 1.3 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 ETS62362.1 - 2.6e-20 72.3 0.2 7.8e-20 70.8 0.2 1.9 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 MA3 PF02847.17 ETS62362.1 - 4.6e-08 33.0 0.1 1.7e-07 31.2 0.0 1.9 2 0 0 2 2 2 1 MA3 domain DUF5345 PF17280.2 ETS62363.1 - 0.35 10.9 2.7 0.92 9.5 2.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Hydrophobin PF01185.18 ETS62364.1 - 1.4e-14 54.5 11.5 4.1e-14 53.0 11.5 1.9 1 0 0 1 1 1 1 Fungal hydrophobin Spore_YpjB PF09577.10 ETS62364.1 - 0.067 13.0 0.6 0.15 11.9 0.6 1.5 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) HSP70 PF00012.20 ETS62365.1 - 3.7e-119 398.6 1.0 8.9e-66 222.3 1.1 2.0 1 1 1 2 2 2 2 Hsp70 protein Ribosomal_S2 PF00318.20 ETS62366.1 - 4.3e-57 192.8 0.0 9.7e-56 188.4 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 ABC_membrane PF00664.23 ETS62367.1 - 1.3e-87 294.0 15.9 9.8e-47 159.9 2.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS62367.1 - 7.1e-60 201.5 0.0 3.6e-29 102.0 0.0 3.1 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 ETS62367.1 - 3.6e-14 52.7 0.1 0.00018 21.0 0.3 4.1 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETS62367.1 - 1.3e-10 41.9 8.6 1.1e-06 29.1 0.3 3.9 3 1 1 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 ETS62367.1 - 3.1e-08 34.0 0.7 0.087 13.1 0.0 4.1 3 1 0 3 3 3 2 AAA domain AAA_21 PF13304.6 ETS62367.1 - 3.5e-07 30.3 0.4 0.13 12.0 0.0 4.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 ETS62367.1 - 3.4e-06 27.3 0.1 0.074 13.1 0.0 3.5 4 0 0 4 4 3 2 Helicase HerA, central domain AAA_29 PF13555.6 ETS62367.1 - 3.6e-06 26.6 0.0 0.039 13.7 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain ABC_ATPase PF09818.9 ETS62367.1 - 8.7e-06 24.8 0.1 0.029 13.2 0.0 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class IstB_IS21 PF01695.17 ETS62367.1 - 4.1e-05 23.4 0.4 1.5 8.5 0.0 4.1 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_30 PF13604.6 ETS62367.1 - 6.4e-05 22.8 0.0 1.7 8.3 0.0 4.0 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 ETS62367.1 - 0.00018 20.9 0.9 0.25 10.6 0.0 2.8 3 0 0 3 3 2 2 Zeta toxin RsgA_GTPase PF03193.16 ETS62367.1 - 0.00028 20.8 0.1 0.89 9.4 0.0 2.8 3 0 0 3 3 2 2 RsgA GTPase AAA_5 PF07728.14 ETS62367.1 - 0.00029 20.9 0.2 1.5 8.8 0.0 3.6 4 0 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETS62367.1 - 0.00031 21.3 0.0 0.32 11.6 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 ETS62367.1 - 0.00042 20.5 1.4 0.44 10.7 0.2 2.9 2 1 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 ETS62367.1 - 0.00066 19.9 1.2 1.1 9.6 0.1 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 ETS62367.1 - 0.0013 18.3 1.0 1.7 8.2 0.0 4.2 5 0 0 5 5 5 1 AAA domain AAA_28 PF13521.6 ETS62367.1 - 0.0016 18.7 0.0 2.7 8.2 0.0 3.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ETS62367.1 - 0.003 17.9 0.0 3.8 7.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase PRK PF00485.18 ETS62367.1 - 0.0033 17.2 0.0 0.2 11.4 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA PF00004.29 ETS62367.1 - 0.0039 17.6 0.0 55 4.2 0.0 4.3 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ETS62367.1 - 0.016 14.6 2.4 22 4.3 0.0 3.4 3 0 0 3 3 3 0 KaiC NACHT PF05729.12 ETS62367.1 - 0.017 15.0 0.1 9.6 6.1 0.0 3.1 3 0 0 3 3 2 0 NACHT domain APS_kinase PF01583.20 ETS62367.1 - 0.023 14.6 0.2 5.8 6.8 0.1 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase G-alpha PF00503.20 ETS62367.1 - 0.027 13.6 0.0 2.9 7.0 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit DUF3987 PF13148.6 ETS62367.1 - 0.031 13.3 0.0 1.6 7.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Mg_chelatase PF01078.21 ETS62367.1 - 0.035 13.5 0.0 2.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI tRNA_lig_kinase PF08303.11 ETS62367.1 - 0.043 13.9 0.0 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 tRNA ligase kinase domain AAA_15 PF13175.6 ETS62367.1 - 0.051 13.3 0.0 6.2 6.4 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Ploopntkinase3 PF18751.1 ETS62367.1 - 0.065 13.1 0.1 3.3 7.6 0.0 2.7 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 AAA_24 PF13479.6 ETS62367.1 - 0.066 12.9 0.0 10 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain FTA4 PF13093.6 ETS62367.1 - 0.09 12.7 0.2 0.24 11.3 0.2 1.7 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 CbiA PF01656.23 ETS62367.1 - 0.16 12.1 0.2 13 5.9 0.0 2.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Sigma54_activ_2 PF14532.6 ETS62367.1 - 0.18 11.9 0.3 25 5.0 0.0 3.0 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_23 PF13476.6 ETS62367.1 - 0.2 12.1 0.0 12 6.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain Cyclin_N PF00134.23 ETS62369.1 - 1.2e-07 31.5 0.0 2.1e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ETS62369.1 - 8.2e-05 23.0 3.7 8.2e-05 23.0 3.7 3.0 2 2 0 2 2 2 1 Cyclin adh_short PF00106.25 ETS62372.1 - 1.5e-38 132.3 0.6 2.3e-38 131.6 0.6 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS62372.1 - 1.4e-21 77.1 0.3 2.1e-21 76.5 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS62372.1 - 2.3e-06 27.6 0.1 5.5e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETS62372.1 - 0.0093 15.1 0.1 0.014 14.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ETS62372.1 - 0.024 14.5 0.0 0.045 13.6 0.0 1.5 1 0 0 1 1 1 0 NAD(P)H-binding tRNA-synt_2 PF00152.20 ETS62373.1 - 2e-90 303.1 0.0 2.6e-90 302.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ETS62373.1 - 6.6e-12 45.3 0.0 1.6e-11 44.1 0.0 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain BOF PF04076.13 ETS62373.1 - 0.066 13.3 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein Gcn1_N PF12074.8 ETS62374.1 - 2.4e-70 237.6 8.6 2.4e-70 237.6 8.6 5.1 4 1 1 5 5 5 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 ETS62374.1 - 3.7e-28 95.1 40.6 0.39 11.1 0.1 22.3 26 0 0 26 26 22 6 HEAT repeat HEAT_2 PF13646.6 ETS62374.1 - 5e-24 84.5 55.5 6.2e-06 26.5 0.0 15.6 11 4 7 18 18 17 8 HEAT repeats HEAT_EZ PF13513.6 ETS62374.1 - 5.2e-21 74.7 46.2 8.6e-05 22.9 0.0 19.9 16 3 3 20 20 19 6 HEAT-like repeat Cnd1 PF12717.7 ETS62374.1 - 8.2e-14 52.0 0.1 0.2 11.7 0.0 10.7 9 3 4 13 13 13 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETS62374.1 - 8.3e-13 48.4 0.0 0.004 16.7 0.0 6.6 4 1 2 6 6 6 3 CLASP N terminal Vac14_Fab1_bd PF12755.7 ETS62374.1 - 2.5e-08 34.4 0.0 2.1 9.0 0.0 8.2 8 2 2 10 10 8 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ETS62374.1 - 2.2e-05 23.3 7.5 0.034 12.7 0.1 6.4 5 2 2 7 7 7 1 Adaptin N terminal region RIX1 PF08167.12 ETS62374.1 - 3.6e-05 23.6 16.4 0.012 15.3 0.1 7.7 8 0 0 8 8 8 2 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 ETS62374.1 - 7.1e-05 23.0 0.0 0.19 12.0 0.0 5.1 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 ETS62374.1 - 0.00016 21.9 2.8 0.32 11.3 0.2 4.6 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion DUF3437 PF11919.8 ETS62374.1 - 0.00028 20.8 0.2 1.6 8.7 0.0 5.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) Arm PF00514.23 ETS62374.1 - 0.0004 20.3 14.1 7.9 6.7 0.1 9.7 9 0 0 9 9 9 1 Armadillo/beta-catenin-like repeat Cnd3 PF12719.7 ETS62374.1 - 0.00044 19.5 0.0 1.1 8.4 0.0 3.8 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain UME PF08064.13 ETS62374.1 - 0.0074 16.2 0.7 38 4.3 0.0 6.0 5 1 1 6 6 6 0 UME (NUC010) domain Dopey_N PF04118.14 ETS62374.1 - 0.017 14.2 0.0 14 4.7 0.0 3.9 3 1 0 3 3 3 0 Dopey, N-terminal MMS19_C PF12460.8 ETS62374.1 - 0.046 12.8 5.0 32 3.5 0.0 5.8 7 1 0 8 8 8 0 RNAPII transcription regulator C-terminal FANCI_S2 PF14676.6 ETS62374.1 - 0.12 12.7 4.0 0.78 10.0 0.1 4.5 5 0 0 5 5 4 0 FANCI solenoid 2 Mito_carr PF00153.27 ETS62375.1 - 1.1e-48 163.1 1.0 4.5e-15 55.3 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Anoctamin PF04547.12 ETS62376.1 - 9.7e-101 337.8 0.1 1.3e-100 337.4 0.1 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel LSM PF01423.22 ETS62377.1 - 4.1e-13 48.8 0.1 9e-13 47.7 0.0 1.6 2 0 0 2 2 2 1 LSM domain GRP PF07172.11 ETS62377.1 - 2.8 8.7 15.3 4.7 8.0 15.3 1.3 1 0 0 1 1 1 0 Glycine rich protein family Trypan_PARP PF05887.11 ETS62378.1 - 0.1 12.6 4.8 0.16 12.0 4.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) EF-hand_6 PF13405.6 ETS62380.1 - 8.9e-11 40.8 1.8 3.7e-05 23.3 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETS62380.1 - 3.2e-10 40.3 0.0 0.00011 22.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETS62380.1 - 9.8e-09 34.2 3.9 0.00015 21.1 0.2 2.9 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 ETS62380.1 - 1.4e-05 24.3 1.1 0.017 14.6 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETS62380.1 - 0.0087 15.9 1.2 2.4 8.1 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_9 PF14658.6 ETS62380.1 - 0.12 12.7 0.0 7.6 6.9 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain NAPRTase PF04095.16 ETS62382.1 - 2e-54 184.7 0.0 3.2e-54 184.1 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 ETS62382.1 - 4.9e-36 123.9 0.0 7.1e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain FCD PF07729.12 ETS62382.1 - 0.14 12.6 1.5 0.22 12.0 0.2 1.9 2 0 0 2 2 2 0 FCD domain Glyco_transf_90 PF05686.12 ETS62383.1 - 1.4e-26 93.4 1.8 1.4e-23 83.5 0.7 2.7 2 1 0 2 2 2 2 Glycosyl transferase family 90 Y_phosphatase PF00102.27 ETS62384.1 - 2.5e-52 177.8 0.1 2.3e-27 96.1 0.0 3.1 3 0 0 3 3 3 3 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ETS62384.1 - 0.088 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Rhodanese PF00581.20 ETS62384.1 - 0.12 13.0 0.0 1.1 9.8 0.0 2.5 2 1 0 2 2 2 0 Rhodanese-like domain PTPlike_phytase PF14566.6 ETS62384.1 - 0.15 12.1 0.1 3 7.9 0.1 2.3 2 0 0 2 2 2 0 Inositol hexakisphosphate Cwf_Cwc_15 PF04889.12 ETS62385.1 - 4.4e-71 239.5 17.8 4.9e-71 239.3 17.8 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein MFMR_assoc PF16596.5 ETS62385.1 - 0.079 13.4 6.5 0.15 12.5 6.5 1.6 1 0 0 1 1 1 0 Disordered region downstream of MFMR RNA_pol_3_Rpc31 PF11705.8 ETS62385.1 - 0.081 13.2 14.2 0.14 12.4 14.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 ETS62385.1 - 0.12 10.6 19.0 0.14 10.4 19.0 1.1 1 0 0 1 1 1 0 Nop14-like family Myc_N PF01056.18 ETS62385.1 - 0.17 11.8 8.1 0.22 11.4 8.1 1.4 1 0 0 1 1 1 0 Myc amino-terminal region SDA1 PF05285.12 ETS62385.1 - 0.19 11.1 22.6 0.25 10.7 22.6 1.1 1 0 0 1 1 1 0 SDA1 PPP4R2 PF09184.11 ETS62385.1 - 0.3 10.6 11.5 0.38 10.3 11.5 1.3 1 0 0 1 1 1 0 PPP4R2 PAC1 PF16094.5 ETS62385.1 - 0.74 8.9 3.1 1 8.5 3.1 1.3 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 DUF4746 PF15928.5 ETS62385.1 - 0.77 9.1 13.4 1 8.7 13.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIIAH PF12685.7 ETS62385.1 - 2.6 7.8 15.4 3.6 7.4 15.4 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF4820 PF16091.5 ETS62385.1 - 2.7 7.3 9.0 3.9 6.8 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) NOA36 PF06524.12 ETS62385.1 - 3.2 7.0 13.6 5.1 6.3 13.6 1.3 1 0 0 1 1 1 0 NOA36 protein Neur_chan_memb PF02932.16 ETS62385.1 - 4.9 7.1 4.8 6.4 6.7 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETS62385.1 - 5.7 6.1 4.8 6.5 5.9 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Sporozoite_P67 PF05642.11 ETS62385.1 - 6.4 4.7 9.4 7.6 4.5 9.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FKBP_C PF00254.28 ETS62386.1 - 2.5e-35 120.7 0.0 3e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Pkinase PF00069.25 ETS62387.1 - 2.5e-71 240.2 0.0 3e-71 239.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62387.1 - 3.9e-36 124.7 0.0 5.2e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS62387.1 - 0.0021 17.4 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETS62387.1 - 0.028 13.8 0.0 0.075 12.4 0.0 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family UPF0220 PF05255.11 ETS62388.1 - 6.1e-54 182.0 0.0 7.3e-54 181.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) PrgI PF12666.7 ETS62388.1 - 0.1 13.3 1.1 0.27 12.0 0.0 2.1 2 0 0 2 2 2 0 PrgI family protein ApbA_C PF08546.11 ETS62389.1 - 1.8e-25 89.6 0.0 3.1e-25 88.8 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ETS62389.1 - 2.4e-20 72.7 0.0 3.6e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ThiF PF00899.21 ETS62389.1 - 0.029 13.7 0.1 0.047 13.0 0.1 1.2 1 0 0 1 1 1 0 ThiF family Pyr_redox PF00070.27 ETS62389.1 - 0.034 14.7 0.2 0.067 13.7 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS62389.1 - 0.3 10.6 2.4 0.8 9.2 1.4 1.8 1 1 1 2 2 2 0 FAD dependent oxidoreductase polyprenyl_synt PF00348.17 ETS62390.1 - 1.9e-54 184.5 0.0 3.6e-54 183.5 0.0 1.5 1 1 0 1 1 1 1 Polyprenyl synthetase DUF3140 PF11338.8 ETS62390.1 - 0.18 12.2 0.5 0.44 11.0 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) RNA_pol_Rpb8 PF03870.15 ETS62391.1 - 1.6e-45 154.7 0.0 1.9e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 Med17 PF10156.9 ETS62392.1 - 0.087 11.5 0.0 3.7 6.1 0.0 2.1 2 0 0 2 2 2 0 Subunit 17 of Mediator complex Lectin_leg-like PF03388.13 ETS62393.1 - 6.8e-63 212.1 0.1 1.5e-62 211.0 0.0 1.4 2 0 0 2 2 2 1 Legume-like lectin family Lectin_legB PF00139.19 ETS62393.1 - 0.0057 16.2 0.0 3 7.3 0.0 2.2 2 0 0 2 2 2 2 Legume lectin domain FAD_binding_4 PF01565.23 ETS62394.1 - 4e-11 42.8 0.3 0.00014 21.6 0.1 2.9 3 0 0 3 3 3 2 FAD binding domain BBE PF08031.12 ETS62394.1 - 3.7e-07 30.1 0.0 1e-06 28.8 0.0 1.7 2 0 0 2 2 2 1 Berberine and berberine like Bromodomain PF00439.25 ETS62395.1 - 3.2e-19 68.8 0.2 5.7e-19 68.0 0.2 1.4 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 ETS62395.1 - 6.4e-05 22.9 0.0 0.00088 19.2 0.0 2.4 2 0 0 2 2 2 1 Bromodomain associated Adeno_VII PF03228.14 ETS62395.1 - 0.024 15.3 0.1 0.8 10.4 0.1 2.6 2 0 0 2 2 2 0 Adenoviral core protein VII TBCC_N PF16752.5 ETS62395.1 - 0.57 10.6 0.0 0.57 10.6 0.0 2.4 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain adh_short_C2 PF13561.6 ETS62396.1 - 3.8e-27 95.4 0.0 3e-25 89.2 0.0 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS62396.1 - 4.5e-24 85.0 0.0 9.7e-24 83.9 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS62396.1 - 9.9e-05 22.3 0.1 0.00023 21.1 0.1 1.5 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ETS62396.1 - 0.15 11.4 0.1 0.26 10.6 0.1 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ETS62396.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pyrid_ox_like PF16242.5 ETS62397.1 - 1.8e-27 95.7 0.1 2.8e-27 95.1 0.1 1.3 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 ETS62397.1 - 2.9e-10 40.2 0.0 1.6e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase GIT_SHD PF08518.11 ETS62398.1 - 3.5e-25 87.3 7.2 2.7e-14 52.5 1.2 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 ETS62398.1 - 0.00045 20.3 0.2 0.00045 20.3 0.2 3.1 4 0 0 4 4 4 1 G protein-coupled receptor kinase-interacting protein 1 C term DUF4686 PF15742.5 ETS62398.1 - 0.22 10.6 24.5 0.48 9.5 24.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) MPS2 PF17060.5 ETS62398.1 - 0.24 10.6 8.1 0.48 9.6 8.1 1.5 1 0 0 1 1 1 0 Monopolar spindle protein 2 Tropomyosin PF00261.20 ETS62398.1 - 0.33 10.3 28.3 5 6.4 28.1 2.5 1 1 0 1 1 1 0 Tropomyosin YabA PF06156.13 ETS62398.1 - 0.56 10.9 16.9 4 8.1 4.7 3.5 3 0 0 3 3 3 0 Initiation control protein YabA KxDL PF10241.9 ETS62398.1 - 0.6 10.4 23.0 0.031 14.6 2.1 4.9 4 1 0 4 4 4 0 Uncharacterized conserved protein Serglycin PF04360.12 ETS62398.1 - 0.99 9.3 4.4 0.63 10.0 0.3 2.6 2 0 0 2 2 2 0 Serglycin Phage_GP20 PF06810.11 ETS62398.1 - 1.1 9.0 16.7 0.14 12.0 5.9 2.9 2 1 1 3 3 3 0 Phage minor structural protein GP20 NPV_P10 PF05531.12 ETS62398.1 - 1.1 9.7 12.0 0.12 12.9 0.5 4.3 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF4201 PF13870.6 ETS62398.1 - 1.2 8.8 20.1 0.57 9.9 6.8 3.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Baculo_PEP_C PF04513.12 ETS62398.1 - 1.2 9.2 19.0 3 7.9 2.5 4.5 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus ABC_tran_CTD PF16326.5 ETS62398.1 - 1.5 9.1 20.1 0.076 13.3 3.6 4.2 1 1 1 3 3 3 0 ABC transporter C-terminal domain Spc7 PF08317.11 ETS62398.1 - 9.6 5.0 36.5 0.032 13.1 24.4 3.0 3 1 1 4 4 4 0 Spc7 kinetochore protein zf-C2H2 PF00096.26 ETS62399.1 - 1.3e-05 25.4 3.2 0.026 15.0 0.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS62399.1 - 2.8e-05 24.6 1.4 0.011 16.5 0.4 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ETS62399.1 - 0.12 12.8 1.9 6.1 7.4 0.4 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Alpha-amylase_C PF02806.18 ETS62400.1 - 1.7e-26 92.5 0.1 5.9e-26 90.8 0.1 2.0 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 ETS62400.1 - 2.9e-16 59.6 0.0 6.8e-16 58.4 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 ETS62400.1 - 3.2e-13 50.0 0.1 1.1e-10 41.6 0.1 2.4 1 1 1 2 2 2 2 Alpha amylase, catalytic domain hDGE_amylase PF14701.6 ETS62400.1 - 0.0039 16.3 0.1 0.038 13.1 0.0 2.0 2 0 0 2 2 2 1 Glycogen debranching enzyme, glucanotransferase domain G-patch PF01585.23 ETS62401.1 - 1.9e-09 37.3 1.5 5.7e-09 35.7 1.5 1.9 1 0 0 1 1 1 1 G-patch domain SDA1 PF05285.12 ETS62401.1 - 0.00028 20.4 56.4 0.022 14.2 30.0 2.2 2 0 0 2 2 2 2 SDA1 YL1 PF05764.13 ETS62401.1 - 0.0017 18.5 52.5 0.14 12.3 26.1 2.2 2 0 0 2 2 2 2 YL1 nuclear protein RR_TM4-6 PF06459.12 ETS62401.1 - 0.017 14.9 38.0 0.4 10.5 19.2 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 G-patch_2 PF12656.7 ETS62401.1 - 0.018 15.1 0.9 0.018 15.1 0.9 4.1 3 1 0 3 3 2 0 G-patch domain CDC45 PF02724.14 ETS62401.1 - 0.12 10.6 45.3 0.16 10.2 22.5 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF2052 PF09747.9 ETS62401.1 - 0.65 10.1 38.4 1.7 8.7 17.8 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) PPP4R2 PF09184.11 ETS62401.1 - 1.5 8.3 40.9 1.5 8.4 20.7 2.2 2 0 0 2 2 2 0 PPP4R2 DUF5427 PF10310.9 ETS62401.1 - 4.4 6.2 41.5 1.4 7.8 12.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5427) SR-25 PF10500.9 ETS62401.1 - 5.1 6.7 85.7 0.021 14.4 17.7 3.6 2 1 1 3 3 3 0 Nuclear RNA-splicing-associated protein Apt1 PF10351.9 ETS62401.1 - 9.3 5.0 33.3 3.5 6.4 16.8 2.2 2 0 0 2 2 2 0 Golgi-body localisation protein domain WD40 PF00400.32 ETS62402.1 - 1e-08 35.7 13.8 0.00019 22.2 0.1 6.2 5 0 0 5 5 5 3 WD domain, G-beta repeat RWD PF05773.22 ETS62402.1 - 5.5e-05 23.4 0.0 0.00011 22.5 0.0 1.4 1 0 0 1 1 1 1 RWD domain G-alpha PF00503.20 ETS62403.1 - 2.6e-113 378.8 0.2 3.2e-113 378.5 0.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETS62403.1 - 2.2e-14 53.3 0.1 2.3e-09 37.0 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETS62403.1 - 0.00022 20.7 0.1 0.54 9.6 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ETS62403.1 - 0.03 14.5 0.2 2.3 8.5 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ETS62403.1 - 0.19 11.5 0.0 0.42 10.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3149 PF11346.8 ETS62404.1 - 0.043 13.4 0.8 0.08 12.6 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Mito_carr PF00153.27 ETS62405.1 - 2.1e-55 184.6 2.9 4.9e-19 68.1 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RhoGEF PF00621.20 ETS62406.1 - 1.4e-33 116.7 0.0 2.9e-29 102.6 0.0 2.4 2 0 0 2 2 2 2 RhoGEF domain Sugar_tr PF00083.24 ETS62407.1 - 1.4e-103 347.2 22.0 1.6e-103 347.0 22.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS62407.1 - 7.4e-32 110.6 32.7 4.3e-30 104.8 15.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ETS62407.1 - 4.8e-07 28.6 7.3 8.8e-07 27.7 2.9 2.3 2 0 0 2 2 2 2 Fungal trichothecene efflux pump (TRI12) VIT1 PF01988.19 ETS62407.1 - 0.32 10.8 7.6 6.8 6.5 3.5 2.5 2 0 0 2 2 2 0 VIT family AMP-binding PF00501.28 ETS62408.1 - 5.5e-81 272.3 0.0 7e-81 272.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS62408.1 - 2.4e-14 54.1 0.1 5.9e-14 52.8 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Phage_T4_Ndd PF06591.11 ETS62408.1 - 0.071 12.9 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 T4-like phage nuclear disruption protein (Ndd) ADH_N PF08240.12 ETS62409.1 - 1.7e-28 98.7 2.9 3e-28 97.8 2.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS62409.1 - 8.9e-14 51.6 0.0 1.5e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ELFV_dehydrog PF00208.21 ETS62409.1 - 0.044 13.5 0.2 0.067 12.9 0.2 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ADH_zinc_N_2 PF13602.6 ETS62409.1 - 0.053 14.6 0.0 0.27 12.3 0.0 2.2 1 1 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ETS62409.1 - 0.17 11.3 0.1 0.4 10.0 0.1 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_N PF08240.12 ETS62410.1 - 3.8e-23 81.4 1.9 6.8e-23 80.6 1.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS62410.1 - 9.8e-16 57.9 0.0 2.4e-15 56.7 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ETS62410.1 - 0.0042 16.5 0.0 0.0068 15.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 ETS62410.1 - 0.0068 17.5 0.0 0.02 16.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PDZ_6 PF17820.1 ETS62410.1 - 0.038 13.8 1.2 0.074 12.9 0.3 1.9 2 0 0 2 2 2 0 PDZ domain PDZ_2 PF13180.6 ETS62410.1 - 0.2 12.0 1.5 1.1 9.6 0.1 2.8 3 2 2 5 5 5 0 PDZ domain adh_short PF00106.25 ETS62410.1 - 0.26 10.7 0.8 0.86 9.0 0.0 2.2 3 0 0 3 3 3 0 short chain dehydrogenase Abhydrolase_6 PF12697.7 ETS62411.1 - 1.3e-13 52.1 2.6 2.9e-13 50.9 0.2 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Esterase PF00756.20 ETS62411.1 - 0.00012 21.8 0.0 0.00019 21.2 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 ETS62411.1 - 0.00015 21.5 0.0 0.00024 20.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Far-17a_AIG1 PF04750.14 ETS62412.1 - 1.8e-33 115.6 1.6 2.2e-33 115.3 1.6 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Sulfatase PF00884.23 ETS62413.1 - 3.7e-56 190.8 0.0 5e-56 190.4 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Choline_sulf_C PF12411.8 ETS62413.1 - 5.3e-25 87.0 2.0 1.3e-24 85.8 2.0 1.7 1 0 0 1 1 1 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 ETS62413.1 - 3.2e-08 33.6 0.0 0.00031 20.4 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 ETS62413.1 - 0.0077 14.9 0.0 0.012 14.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) Sulfatase_C PF14707.6 ETS62413.1 - 0.013 16.3 0.0 0.035 14.9 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 ETS62413.1 - 0.02 14.8 0.0 4.5 7.2 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function TatD_DNase PF01026.21 ETS62414.1 - 4.6e-36 124.5 0.0 5.9e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Sulfatase PF00884.23 ETS62415.1 - 1.1e-49 169.6 0.4 1.4e-49 169.2 0.4 1.1 1 0 0 1 1 1 1 Sulfatase Transferase PF02458.15 ETS62416.1 - 1.2e-19 70.3 0.0 1.9e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 Transferase family NmrA PF05368.13 ETS62417.1 - 2.9e-16 59.8 0.0 4e-16 59.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ETS62417.1 - 3.4e-13 49.9 0.0 6.6e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETS62417.1 - 3.5e-05 23.4 0.0 0.00034 20.1 0.0 2.3 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS62417.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase FMN_red PF03358.15 ETS62418.1 - 3.8e-23 81.9 0.0 6.2e-23 81.3 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ETS62418.1 - 0.0013 18.5 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold adh_short PF00106.25 ETS62419.1 - 9.2e-34 116.6 0.3 1.4e-33 116.1 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS62419.1 - 4.8e-17 62.3 0.2 7.7e-17 61.6 0.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS62419.1 - 2.7e-11 43.7 2.9 5.5e-10 39.4 2.9 2.2 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETS62419.1 - 0.007 15.5 0.1 0.0092 15.1 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ETS62419.1 - 0.014 15.3 0.7 0.024 14.5 0.7 1.6 1 1 0 1 1 1 0 NAD(P)H-binding Shikimate_DH PF01488.20 ETS62419.1 - 0.073 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NicO PF03824.16 ETS62420.1 - 1.5e-35 122.9 1.8 5.7e-34 117.8 0.4 3.2 2 1 0 2 2 2 1 High-affinity nickel-transport protein Abhydrolase_3 PF07859.13 ETS62420.1 - 7.2e-21 75.0 0.1 3.4e-19 69.5 0.1 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold 4HBT_2 PF13279.6 ETS62420.1 - 1.6e-05 25.4 0.0 3.2e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Thioesterase-like superfamily Xan_ur_permease PF00860.20 ETS62420.1 - 0.0018 17.0 0.7 0.0018 17.0 0.7 1.9 2 0 0 2 2 2 1 Permease family CompInhib_SCIN PF11546.8 ETS62423.1 - 0.054 13.5 0.1 0.29 11.2 0.0 1.9 1 1 1 2 2 2 0 Staphylococcal complement inhibitor SCIN Sterile PF03015.19 ETS62423.1 - 0.14 12.4 0.1 14 6.0 0.1 2.3 2 0 0 2 2 2 0 Male sterility protein Rrn6 PF10214.9 ETS62423.1 - 0.15 10.6 1.2 0.18 10.2 1.2 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Fungal_trans PF04082.18 ETS62424.1 - 3.5e-25 88.5 0.1 5.8e-25 87.8 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS62424.1 - 1.7e-07 31.2 11.1 3.4e-07 30.3 11.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain p450 PF00067.22 ETS62425.1 - 6.7e-71 239.4 0.0 8.1e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAA_hydrolase PF01557.18 ETS62425.1 - 8.8e-54 182.5 0.0 1.6e-53 181.6 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 ETS62425.1 - 1.3e-21 76.8 0.0 3.2e-21 75.5 0.0 1.7 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal PGAP1 PF07819.13 ETS62426.1 - 0.03 14.0 0.1 0.057 13.1 0.0 1.5 2 0 0 2 2 2 0 PGAP1-like protein Cyclin PF08613.11 ETS62427.1 - 1.2e-31 110.2 0.2 2.9e-31 109.0 0.2 1.8 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ETS62427.1 - 0.00017 21.3 0.2 0.00027 20.7 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain FeS_assembly_P PF01883.19 ETS62428.1 - 4.9e-12 45.9 0.0 1.1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein NOA36 PF06524.12 ETS62428.1 - 0.41 9.9 2.9 0.57 9.5 2.9 1.2 1 0 0 1 1 1 0 NOA36 protein Med19 PF10278.9 ETS62429.1 - 0.024 14.6 0.3 0.049 13.6 0.2 1.5 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 MDM10 PF12519.8 ETS62430.1 - 1.6e-94 317.4 0.1 5.6e-47 160.7 0.0 3.0 1 1 0 3 3 3 3 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 ETS62430.1 - 0.025 14.1 0.0 0.15 11.5 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic porin 4HBT_3 PF13622.6 ETS62431.1 - 6.6e-19 69.1 0.1 1.1e-18 68.4 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily NTF2 PF02136.20 ETS62432.1 - 6.1e-28 97.8 0.5 1.2e-27 96.8 0.5 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 ETS62432.1 - 7.8e-06 25.6 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4518 PF15008.6 ETS62432.1 - 0.00027 20.2 0.4 0.0004 19.7 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4518) RHD3 PF05879.12 ETS62433.1 - 6.2e-247 821.5 0.4 8e-247 821.1 0.4 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ETS62433.1 - 1.8e-06 27.4 0.2 4.8e-06 26.0 0.2 1.7 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 ETS62433.1 - 4.3e-05 23.6 0.0 0.00012 22.1 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETS62433.1 - 6.5e-05 23.0 0.0 0.00029 20.9 0.0 2.1 2 0 0 2 2 2 1 Dynamin family AAA_28 PF13521.6 ETS62433.1 - 0.0003 21.1 0.0 0.0013 19.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain PTS_IIA PF02255.16 ETS62433.1 - 0.03 14.4 2.1 0.087 12.9 2.1 1.7 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Insulin_TMD PF17870.1 ETS62433.1 - 0.21 11.7 0.2 0.45 10.6 0.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Pyr_redox_2 PF07992.14 ETS62434.1 - 4.6e-36 124.5 0.0 1.8e-32 112.8 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS62434.1 - 5.1e-10 39.8 0.1 2.9e-09 37.4 0.1 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HSP20 PF00011.21 ETS62435.1 - 0.0036 17.4 0.0 0.0081 16.3 0.0 1.5 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF4774 PF15999.5 ETS62435.1 - 0.45 10.4 4.3 0.18 11.7 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4774) MRP-S33 PF08293.11 ETS62436.1 - 1.9e-28 98.5 0.1 2.3e-28 98.2 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Peptidase_C14 PF00656.22 ETS62437.1 - 9.3e-60 202.6 0.2 1.2e-59 202.3 0.2 1.0 1 0 0 1 1 1 1 Caspase domain YflT PF11181.8 ETS62437.1 - 0.25 11.9 0.8 0.48 11.0 0.1 1.8 2 0 0 2 2 2 0 Heat induced stress protein YflT MBOAT PF03062.19 ETS62438.1 - 1.5e-51 175.8 4.2 1.5e-51 175.8 4.2 2.3 1 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF4796 PF16044.5 ETS62438.1 - 0.17 11.4 0.2 0.29 10.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4796) Methyltransf_3 PF01596.17 ETS62439.1 - 1.1e-45 155.5 0.2 1.4e-45 155.1 0.2 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ETS62439.1 - 2.6e-11 44.5 0.0 6.4e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ETS62439.1 - 0.0024 17.7 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ETS62439.1 - 0.0031 17.2 0.0 0.0054 16.4 0.0 1.4 1 1 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 ETS62439.1 - 0.0052 17.5 0.0 0.012 16.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain P22_CoatProtein PF11651.8 ETS62439.1 - 0.0097 14.5 0.1 0.02 13.5 0.0 1.5 2 0 0 2 2 2 1 P22 coat protein - gene protein 5 RrnaAD PF00398.20 ETS62439.1 - 0.024 13.7 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase TBCC PF07986.12 ETS62440.1 - 1.8e-11 43.8 2.1 3e-11 43.1 2.1 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 ETS62440.1 - 0.00045 20.6 0.1 0.00087 19.7 0.1 1.5 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain ABC_tran_CTD PF16326.5 ETS62440.1 - 0.31 11.3 0.8 0.79 10.0 0.6 1.9 1 1 0 1 1 1 0 ABC transporter C-terminal domain Chorismate_synt PF01264.21 ETS62441.1 - 5.4e-138 459.2 0.3 6.6e-138 458.9 0.3 1.1 1 0 0 1 1 1 1 Chorismate synthase EthD PF07110.11 ETS62442.1 - 6.5e-07 30.4 0.3 0.003 18.7 0.0 2.5 2 0 0 2 2 2 2 EthD domain Coatomer_WDAD PF04053.14 ETS62443.1 - 2.9e-148 494.6 0.0 3.5e-147 491.0 0.0 2.5 2 1 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 ETS62443.1 - 4.9e-40 134.8 8.9 1.4e-07 32.1 0.0 8.4 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62443.1 - 8.3e-12 45.2 0.1 0.0024 18.1 0.0 6.2 4 1 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain TPR_2 PF07719.17 ETS62443.1 - 0.054 13.6 0.2 17 5.8 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat Nup160 PF11715.8 ETS62443.1 - 0.12 11.0 1.6 1.1 7.9 0.0 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 TPR_4 PF07721.14 ETS62443.1 - 1.6 9.6 5.5 2.7 8.9 1.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Vps5 PF09325.10 ETS62444.1 - 2.6e-14 53.3 6.0 4e-14 52.7 6.0 1.2 1 0 0 1 1 1 1 Vps5 C terminal like 5_nucleotid PF05761.14 ETS62444.1 - 0.1 11.5 2.2 0.15 11.0 2.2 1.1 1 0 0 1 1 1 0 5' nucleotidase family UPF0242 PF06785.11 ETS62444.1 - 9.9 6.2 11.2 28 4.7 9.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus RNase_T PF00929.24 ETS62445.1 - 4.1e-17 63.2 0.0 5.7e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Exonuclease Chrome_Resist PF09828.9 ETS62445.1 - 0.089 13.2 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Chromate resistance exported protein 2-Hacid_dh_C PF02826.19 ETS62446.1 - 6.4e-52 175.5 0.0 1.1e-51 174.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETS62446.1 - 8.2e-15 54.6 0.0 1.3e-14 54.0 0.0 1.3 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GFO_IDH_MocA PF01408.22 ETS62446.1 - 0.039 14.8 0.0 0.097 13.5 0.0 1.7 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 ETS62446.1 - 0.05 14.2 0.1 0.2 12.2 0.0 2.1 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Pectate_lyase_3 PF12708.7 ETS62447.1 - 1.3e-94 316.1 6.8 1.3e-79 267.0 1.5 3.0 3 0 0 3 3 3 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 ETS62447.1 - 2.2e-07 30.5 1.1 0.0065 16.1 0.5 2.7 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase PP2C PF00481.21 ETS62448.1 - 3.5e-64 216.9 0.1 3.7e-51 174.2 0.2 2.1 2 0 0 2 2 2 2 Protein phosphatase 2C HMG_box PF00505.19 ETS62449.1 - 6.1e-21 74.6 14.7 9.7e-11 41.9 3.5 2.9 2 1 0 2 2 2 2 HMG (high mobility group) box Methyltransf_16 PF10294.9 ETS62449.1 - 2.6e-17 63.1 0.4 2.9e-12 46.7 0.1 2.2 1 1 1 2 2 2 2 Lysine methyltransferase HMG_box_2 PF09011.10 ETS62449.1 - 8.9e-17 61.5 11.0 5.4e-08 33.3 2.9 2.5 2 0 0 2 2 2 2 HMG-box domain Methyltransf_25 PF13649.6 ETS62449.1 - 0.02 15.6 0.1 0.17 12.6 0.0 2.4 1 1 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 ETS62449.1 - 0.03 13.9 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain YABBY PF04690.13 ETS62449.1 - 0.063 13.8 5.9 0.11 13.1 4.9 1.9 1 1 0 1 1 1 0 YABBY protein CRAL_TRIO PF00650.20 ETS62451.1 - 3e-36 124.5 0.1 4.6e-36 123.9 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ETS62451.1 - 1.4e-09 38.0 0.2 4.7e-09 36.3 0.0 2.1 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain Acetyltransf_1 PF00583.25 ETS62452.1 - 4.1e-14 52.8 0.0 4.7e-14 52.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETS62452.1 - 7.2e-10 38.9 0.1 8.2e-10 38.7 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS62452.1 - 2.4e-07 31.1 0.1 3.1e-07 30.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS62452.1 - 1.3e-05 25.1 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ETS62452.1 - 0.00029 20.9 0.0 0.00055 20.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ETS62452.1 - 0.14 11.6 0.2 0.26 10.8 0.0 1.5 2 0 0 2 2 2 0 Putative acetyl-transferase RNase_H PF00075.24 ETS62454.1 - 1.3e-05 25.4 0.0 3.6e-05 24.0 0.0 1.6 2 0 0 2 2 2 1 RNase H DUF5102 PF17104.5 ETS62455.1 - 1.1e-51 176.7 14.6 1.1e-51 176.7 14.6 3.2 1 1 1 3 3 3 1 Domain of unknown function (DUF5102) FEZ PF07763.13 ETS62455.1 - 0.03 14.0 6.2 0.038 13.7 0.2 2.8 3 0 0 3 3 3 0 FEZ-like protein Prenyltransf PF01255.19 ETS62456.1 - 3.3e-71 239.4 0.0 4.1e-71 239.1 0.0 1.1 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Peptidase_S26 PF10502.9 ETS62457.1 - 4.5e-06 26.5 0.0 0.0013 18.6 0.0 2.5 2 0 0 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 ETS62457.1 - 8e-05 22.5 0.0 0.00037 20.4 0.0 2.0 1 1 0 1 1 1 1 Peptidase S24-like RhoGEF PF00621.20 ETS62458.1 - 2.3e-24 86.6 0.2 3.7e-11 43.6 0.0 2.7 3 0 0 3 3 3 2 RhoGEF domain DPBB_1 PF03330.18 ETS62459.1 - 0.0058 16.9 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 Lytic transglycolase CAP_GLY PF01302.25 ETS62460.1 - 1.4e-20 73.1 0.1 2.1e-20 72.5 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 ETS62460.1 - 1.6e-15 56.9 5.9 1.2e-07 31.9 0.4 3.8 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETS62460.1 - 1.9e-12 46.7 9.4 4.6e-08 32.7 1.4 4.3 2 2 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 ETS62460.1 - 2.8e-08 33.4 0.1 9.4e-05 22.0 0.0 2.9 2 1 1 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 ETS62460.1 - 0.0041 17.5 7.3 7.9 7.5 0.0 5.5 5 1 0 5 5 5 1 Leucine Rich Repeat RNase_II_C_S1 PF18614.1 ETS62460.1 - 0.11 12.5 3.4 0.11 12.4 0.0 2.6 2 1 0 2 2 2 0 RNase II-type exonuclease C-terminal S1 domain LRR_6 PF13516.6 ETS62460.1 - 0.53 10.5 9.5 12 6.2 0.1 5.1 6 0 0 6 6 6 0 Leucine Rich repeat STIMATE PF12400.8 ETS62463.1 - 2.1e-41 141.4 0.1 3.9e-41 140.5 0.1 1.5 1 0 0 1 1 1 1 STIMATE family GN3L_Grn1 PF08701.11 ETS62464.1 - 1.8e-24 85.6 16.9 1.8e-24 85.6 16.9 4.4 5 0 0 5 5 5 1 GNL3L/Grn1 putative GTPase DUF2457 PF10446.9 ETS62464.1 - 0.00047 19.4 20.9 0.00047 19.4 20.9 3.9 3 1 0 3 3 3 1 Protein of unknown function (DUF2457) TFIIF_alpha PF05793.12 ETS62464.1 - 0.0028 16.3 31.9 0.0028 16.3 31.9 3.7 3 1 0 3 3 3 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 ETS62464.1 - 0.76 7.9 48.0 0.035 12.3 18.3 3.3 3 0 0 3 3 3 0 Nop14-like family RRN3 PF05327.11 ETS62465.1 - 1.2e-183 611.6 0.0 1.2e-183 611.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 GCIP PF13324.6 ETS62465.1 - 1.9 8.0 10.1 0.69 9.5 1.0 2.6 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting BNIP2 PF12496.8 ETS62465.1 - 3.1 8.3 8.9 0.76 10.2 2.9 2.4 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Thioredoxin PF00085.20 ETS62466.1 - 2.3e-16 59.6 0.1 2.8e-16 59.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ETS62466.1 - 2.1e-06 28.0 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ETS62466.1 - 0.00015 21.7 0.0 0.00017 21.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 ETS62466.1 - 0.00015 21.9 0.1 0.0002 21.5 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 ETS62466.1 - 0.0021 18.5 0.1 0.0036 17.7 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain DUF836 PF05768.14 ETS62466.1 - 0.0057 17.1 0.0 0.0096 16.3 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Redoxin PF08534.10 ETS62466.1 - 0.012 15.3 0.2 0.025 14.3 0.2 1.5 1 1 0 2 2 2 0 Redoxin Glutaredoxin PF00462.24 ETS62466.1 - 0.11 12.7 0.2 0.23 11.7 0.2 1.6 1 1 0 1 1 1 0 Glutaredoxin Adaptin_N PF01602.20 ETS62469.1 - 9.3e-123 410.5 11.7 1.1e-122 410.2 11.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 ETS62469.1 - 1.6e-40 137.8 0.0 4.3e-40 136.4 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ETS62469.1 - 2.1e-14 53.8 0.0 5.5e-14 52.4 0.0 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain 14-3-3 PF00244.20 ETS62470.1 - 1.6e-107 358.1 4.2 2e-107 357.8 4.2 1.1 1 0 0 1 1 1 1 14-3-3 protein Ras PF00071.22 ETS62471.1 - 3.3e-50 169.9 0.0 3.9e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS62471.1 - 2.9e-30 105.0 0.0 4.4e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS62471.1 - 2.5e-10 40.1 0.0 3.1e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETS62471.1 - 8.4e-05 22.0 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS62471.1 - 0.001 19.2 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ETS62471.1 - 0.0011 18.2 0.7 0.37 9.9 0.1 2.6 2 1 1 3 3 3 2 G-protein alpha subunit Pox_A32 PF04665.12 ETS62471.1 - 0.016 14.7 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein RNA_helicase PF00910.22 ETS62471.1 - 0.017 15.5 0.1 0.14 12.5 0.1 2.1 1 1 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 ETS62471.1 - 0.028 13.9 0.0 0.045 13.3 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF5118 PF17162.4 ETS62471.1 - 0.037 13.8 0.1 0.071 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) RsgA_GTPase PF03193.16 ETS62471.1 - 0.049 13.5 0.0 6.6 6.6 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ETS62471.1 - 0.052 13.9 0.0 0.098 13.0 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 ETS62471.1 - 0.055 13.2 0.1 0.083 12.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETS62471.1 - 0.094 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ETS62471.1 - 0.12 12.5 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain STAS PF01740.21 ETS62471.1 - 0.13 11.9 0.0 0.29 10.8 0.0 1.6 1 1 0 1 1 1 0 STAS domain Septin PF00735.18 ETS62471.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Septin ATPase PF06745.13 ETS62471.1 - 0.18 11.1 0.1 0.27 10.5 0.1 1.2 1 0 0 1 1 1 0 KaiC RPA43_OB PF17875.1 ETS62472.1 - 4e-21 75.9 5.7 6.2e-14 52.7 0.0 3.3 3 1 1 4 4 4 2 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 ETS62472.1 - 5.4e-05 23.5 0.0 0.00012 22.4 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 FUSC_2 PF13515.6 ETS62473.1 - 2.4e-14 53.6 6.7 2.4e-14 53.6 6.7 2.6 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 ETS62473.1 - 9.8e-14 50.8 9.4 9.8e-14 50.8 9.4 3.0 4 0 0 4 4 4 1 Fusaric acid resistance protein family ALMT PF11744.8 ETS62473.1 - 3.7e-08 32.7 2.9 3.7e-08 32.7 2.9 2.1 3 0 0 3 3 3 1 Aluminium activated malate transporter ArAE_1 PF06081.11 ETS62473.1 - 1.2e-05 25.5 2.3 1.2e-05 25.5 2.3 2.2 2 0 0 2 2 2 1 Aromatic acid exporter family member 1 ArAE_2 PF10334.9 ETS62473.1 - 1.4e-05 25.1 1.1 3.3e-05 23.8 1.1 1.6 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 ETS62473.1 - 3.4e-05 23.1 2.9 0.00016 20.9 0.0 2.6 3 0 0 3 3 3 1 Putative ER transporter, 6TM, N-terminal FCD PF07729.12 ETS62473.1 - 0.12 12.8 0.1 0.12 12.8 0.1 2.6 3 0 0 3 3 3 0 FCD domain PTH2 PF01981.16 ETS62474.1 - 1.3e-06 28.6 0.8 2.9e-06 27.5 0.8 1.6 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Sybindin PF04099.12 ETS62475.1 - 1.2e-33 116.1 0.0 2e-16 60.2 0.0 2.2 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.13 ETS62475.1 - 0.00017 21.7 0.0 0.00027 21.1 0.0 1.3 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region eIF3m_C_helix PF18005.1 ETS62476.1 - 1e-12 47.5 0.5 1e-12 47.5 0.5 2.0 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 ETS62476.1 - 1.5e-10 41.5 0.0 3.5e-10 40.3 0.0 1.7 1 0 0 1 1 1 1 PCI domain Pex19 PF04614.12 ETS62476.1 - 0.23 11.2 1.8 0.18 11.6 0.3 1.5 2 0 0 2 2 2 0 Pex19 protein family CTP_transf_like PF01467.26 ETS62477.1 - 3e-05 24.2 0.0 8.4e-05 22.8 0.0 1.8 1 0 0 1 1 1 1 Cytidylyltransferase-like IFT20 PF14931.6 ETS62477.1 - 0.12 12.6 0.2 2.4 8.4 0.1 2.7 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Coatomer_E PF04733.14 ETS62478.1 - 2.3e-42 145.4 6.1 2.6e-42 145.2 6.1 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_20 PF14561.6 ETS62478.1 - 0.038 14.3 0.5 0.038 14.3 0.5 3.5 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETS62478.1 - 0.082 13.8 1.1 0.082 13.8 1.1 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat Mak16 PF04874.14 ETS62478.1 - 0.13 12.8 0.1 0.25 12.0 0.1 1.4 1 0 0 1 1 1 0 Mak16 protein C-terminal region TPR_17 PF13431.6 ETS62478.1 - 0.31 11.5 2.5 0.64 10.5 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETS62478.1 - 0.63 10.6 19.2 5.5 7.6 3.4 4.7 3 3 1 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS62478.1 - 5.4 7.3 9.3 5.8 7.2 0.1 3.7 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Hist_deacetyl PF00850.19 ETS62479.1 - 5.5e-80 269.1 0.1 9.2e-80 268.4 0.0 1.4 2 0 0 2 2 2 1 Histone deacetylase domain DUF3237 PF11578.8 ETS62480.1 - 7e-32 110.3 0.0 8.6e-32 110.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) CENP-I PF07778.11 ETS62481.1 - 7.5 5.1 6.6 9.9 4.7 6.6 1.1 1 0 0 1 1 1 0 Mis6 F-box-like PF12937.7 ETS62482.1 - 3.6e-11 42.8 3.6 3.6e-11 42.8 3.6 2.4 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ETS62482.1 - 2.3e-07 31.0 4.2 0.46 11.0 0.0 6.6 5 1 3 8 8 8 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETS62482.1 - 7e-06 25.7 19.0 0.85 9.8 0.1 9.4 11 0 0 11 11 11 2 Leucine Rich repeat F-box PF00646.33 ETS62482.1 - 2.6e-05 24.0 5.7 4.8e-05 23.1 1.2 3.3 4 0 0 4 4 4 1 F-box domain SAM_Ste50p PF09235.10 ETS62482.1 - 0.27 11.5 2.8 26 5.2 0.0 3.6 3 0 0 3 3 3 0 Ste50p, sterile alpha motif LRR_1 PF00560.33 ETS62482.1 - 0.44 11.3 10.5 1.3e+02 3.7 0.0 6.8 8 0 0 8 8 8 0 Leucine Rich Repeat P21-Arc PF04062.14 ETS62484.1 - 4.2e-77 258.1 0.0 4.7e-77 257.9 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 ETS62484.1 - 0.29 11.2 0.0 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Pancreatic hormone peptide Asp_protease PF09668.10 ETS62485.1 - 1.9e-58 195.7 0.0 2.8e-58 195.1 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 ETS62485.1 - 1.3e-22 80.2 0.0 3.1e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ETS62485.1 - 8.6e-12 45.5 0.1 3.1e-11 43.8 0.0 2.0 2 0 0 2 2 1 1 Aspartyl protease ubiquitin PF00240.23 ETS62485.1 - 6.1e-11 41.9 0.0 1.2e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA_4 PF14555.6 ETS62485.1 - 3.7e-05 23.4 0.3 0.00011 22.0 0.3 1.8 1 0 0 1 1 1 1 UBA-like domain Rad60-SLD PF11976.8 ETS62485.1 - 0.0016 18.2 0.1 0.0035 17.2 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like RVP PF00077.20 ETS62485.1 - 0.003 17.8 0.0 0.0066 16.7 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP_2 PF08284.11 ETS62485.1 - 0.012 15.4 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 Retroviral aspartyl protease FlgN PF05130.12 ETS62485.1 - 0.034 14.7 0.9 0.094 13.2 0.9 1.7 1 0 0 1 1 1 0 FlgN protein XPC-binding PF09280.11 ETS62485.1 - 0.044 13.5 5.1 0.11 12.2 5.1 1.7 1 0 0 1 1 1 0 XPC-binding domain Bep_C_terminal PF17841.1 ETS62485.1 - 0.089 13.0 0.6 4.3 7.6 0.2 2.5 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) UBA PF00627.31 ETS62485.1 - 0.17 11.8 0.1 0.17 11.8 0.1 2.6 3 0 0 3 3 3 0 UBA/TS-N domain Mob1_phocein PF03637.17 ETS62486.1 - 6.6e-60 202.0 0.2 8e-60 201.7 0.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family ABC_tran PF00005.27 ETS62487.1 - 8.9e-45 152.6 0.0 4.5e-22 79.0 0.0 3.0 3 0 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ETS62487.1 - 2.4e-21 75.6 2.9 2.4e-21 75.6 2.9 2.7 4 0 0 4 4 2 1 ABC transporter AAA_21 PF13304.6 ETS62487.1 - 6.9e-17 62.2 6.1 0.0004 20.3 0.1 4.3 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ETS62487.1 - 1.2e-08 35.1 0.0 0.029 14.1 0.1 3.8 2 2 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 ETS62487.1 - 4.7e-08 32.7 0.8 0.002 17.9 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain SMC_N PF02463.19 ETS62487.1 - 1.2e-07 31.4 2.4 0.49 9.8 0.0 4.2 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETS62487.1 - 2.3e-07 31.5 19.6 0.00073 20.1 1.9 4.5 4 1 0 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 ETS62487.1 - 1.3e-06 28.5 1.3 0.0034 17.3 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase Dynamin_N PF00350.23 ETS62487.1 - 6.4e-06 26.3 4.7 0.092 12.8 0.0 4.4 2 1 1 3 3 3 2 Dynamin family AAA_16 PF13191.6 ETS62487.1 - 2.3e-05 24.9 0.0 0.025 15.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 ETS62487.1 - 6e-05 23.1 5.6 0.0024 17.9 0.1 3.6 4 1 0 4 4 2 1 50S ribosome-binding GTPase NACHT PF05729.12 ETS62487.1 - 8.7e-05 22.5 0.9 0.45 10.4 0.1 2.5 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 ETS62487.1 - 9.7e-05 22.2 0.2 1.1 8.9 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ETS62487.1 - 0.00012 22.3 0.3 0.34 11.2 0.1 3.2 2 2 1 3 3 3 1 AAA domain FeoB_N PF02421.18 ETS62487.1 - 0.00087 18.8 0.1 0.078 12.5 0.1 2.6 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_30 PF13604.6 ETS62487.1 - 0.00093 19.0 0.1 0.36 10.5 0.2 3.2 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 ETS62487.1 - 0.001 19.5 1.6 4.5 7.7 0.0 4.1 4 1 0 4 4 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ETS62487.1 - 0.0011 19.2 0.0 1.3 9.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ETS62487.1 - 0.0022 17.6 0.1 4.6 6.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 ETS62487.1 - 0.0046 17.2 0.0 5.6 7.2 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 ETS62487.1 - 0.0083 16.7 0.3 8.3 7.0 0.1 3.1 3 1 0 3 3 2 0 AAA domain NB-ARC PF00931.22 ETS62487.1 - 0.018 14.3 0.1 0.65 9.1 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain AAA_5 PF07728.14 ETS62487.1 - 0.02 14.9 0.4 1.1 9.2 0.1 2.8 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) FtsK_SpoIIIE PF01580.18 ETS62487.1 - 0.02 14.2 0.1 1.9 7.8 0.0 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family Pox_A32 PF04665.12 ETS62487.1 - 0.029 13.8 1.3 2.2 7.7 0.1 2.8 2 1 1 3 3 3 0 Poxvirus A32 protein AAA_33 PF13671.6 ETS62487.1 - 0.037 14.2 0.3 16 5.7 0.0 2.9 3 0 0 3 3 2 0 AAA domain cobW PF02492.19 ETS62487.1 - 0.038 13.6 0.3 6.5 6.3 0.0 2.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ETS62487.1 - 0.039 14.4 0.5 4 7.9 0.0 3.0 3 0 0 3 3 2 0 RNA helicase DAP3 PF10236.9 ETS62487.1 - 0.057 12.6 1.2 6.8 5.8 0.0 3.1 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 AAA_7 PF12775.7 ETS62487.1 - 0.068 12.7 0.3 1.9 7.9 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region T2SSE PF00437.20 ETS62487.1 - 0.07 12.2 0.3 8.7 5.3 0.0 2.6 3 0 0 3 3 3 0 Type II/IV secretion system protein DUF87 PF01935.17 ETS62487.1 - 0.12 12.4 8.3 1 9.4 0.0 4.2 3 1 1 4 4 4 0 Helicase HerA, central domain SRP54 PF00448.22 ETS62487.1 - 0.15 11.7 3.5 1.8 8.1 0.0 3.1 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain TsaE PF02367.17 ETS62487.1 - 0.18 11.8 0.6 8.5 6.4 0.1 2.7 2 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 ETS62487.1 - 0.47 10.4 4.7 1.9 8.4 0.1 3.5 4 0 0 4 4 3 0 NTPase Ribosomal_L23eN PF03939.13 ETS62487.1 - 0.48 10.7 4.1 1.2 9.4 4.1 1.7 1 0 0 1 1 1 0 Ribosomal protein L23, N-terminal domain DivIC PF04977.15 ETS62487.1 - 1.8 8.4 14.9 1.4 8.7 1.7 3.1 3 0 0 3 3 3 0 Septum formation initiator DLIC PF05783.11 ETS62487.1 - 3.1 6.5 10.3 4.3 6.0 0.0 3.2 3 0 0 3 3 3 0 Dynein light intermediate chain (DLIC) MRP-L27 PF09809.9 ETS62488.1 - 7.5e-05 22.5 1.6 0.0034 17.2 1.6 2.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L27 LEA_5 PF00477.17 ETS62488.1 - 0.052 14.0 0.1 0.16 12.4 0.0 1.7 1 1 1 2 2 2 0 Small hydrophilic plant seed protein SPRY PF00622.28 ETS62490.1 - 5.2e-06 26.6 0.0 0.00012 22.1 0.0 2.6 2 0 0 2 2 2 1 SPRY domain DEAD PF00270.29 ETS62492.1 - 7.6e-41 139.8 0.0 1.6e-40 138.7 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS62492.1 - 2.5e-23 82.5 0.0 1.1e-22 80.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS62492.1 - 0.00056 20.0 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Erv26 PF04148.13 ETS62493.1 - 2.6e-11 43.7 2.3 1.1e-10 41.7 2.3 1.8 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 TMEM191C PF15194.6 ETS62493.1 - 1.8 8.7 5.2 0.97 9.6 0.3 2.2 1 1 1 2 2 2 0 TMEM191C family Acyl-CoA_dh_N PF02771.16 ETS62494.1 - 2.8e-27 95.6 0.0 5.2e-27 94.8 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 ETS62494.1 - 2.3e-24 86.3 0.0 3.5e-24 85.7 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS62494.1 - 6.6e-21 74.3 0.0 1.4e-20 73.3 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETS62494.1 - 1.9e-08 34.6 0.0 4.4e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain TMEM223 PF14640.6 ETS62495.1 - 0.14 12.3 0.1 0.53 10.4 0.0 1.8 2 0 0 2 2 2 0 Transmembrane protein 223 Mod_r PF07200.13 ETS62496.1 - 2.2e-28 99.2 4.3 2.2e-28 99.2 4.3 1.7 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein NUDIX PF00293.28 ETS62497.1 - 1.2e-10 41.5 0.0 3.4e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 NUDIX domain Iso_dh PF00180.20 ETS62499.1 - 2.4e-79 267.0 0.0 3.1e-79 266.7 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase COesterase PF00135.28 ETS62500.1 - 4.6e-64 217.1 0.0 4e-63 214.0 0.0 2.0 2 0 0 2 2 2 1 Carboxylesterase family DnaJ PF00226.31 ETS62500.1 - 5.2e-11 42.5 0.2 2.1e-09 37.3 0.1 3.0 2 1 0 2 2 2 1 DnaJ domain zf-CSL PF05207.13 ETS62500.1 - 9.3e-11 41.3 0.6 1.9e-10 40.3 0.6 1.6 1 0 0 1 1 1 1 CSL zinc finger Abhydrolase_3 PF07859.13 ETS62500.1 - 6.2e-05 22.9 0.0 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold ZZ PF00569.17 ETS62500.1 - 0.041 13.7 0.4 0.32 10.9 0.1 2.2 2 0 0 2 2 2 0 Zinc finger, ZZ type zinc_ribbon_4 PF13717.6 ETS62500.1 - 0.3 11.1 0.6 0.58 10.1 0.6 1.5 1 0 0 1 1 1 0 zinc-ribbon domain Ribosomal_L18 PF17135.4 ETS62502.1 - 2.3e-84 281.4 1.3 3.4e-84 280.9 1.3 1.2 1 1 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 ETS62502.1 - 0.001 19.7 1.3 0.0015 19.2 0.0 2.0 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A VID27 PF08553.10 ETS62503.1 - 1.2e-163 544.3 0.0 1.7e-163 543.8 0.0 1.2 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 ETS62503.1 - 5.9e-55 185.8 0.5 5.9e-55 185.8 0.5 2.9 2 1 1 3 3 3 1 VID27 N-terminal region VID27_PH PF17747.1 ETS62503.1 - 1.1e-32 112.6 5.3 3.7e-32 110.8 3.8 2.4 2 0 0 2 2 2 1 VID27 PH-like domain eIF-3_zeta PF05091.12 ETS62504.1 - 1.7e-202 674.0 0.0 2e-202 673.8 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Keratin_2_head PF16208.5 ETS62504.1 - 1.9 8.6 26.6 3.9 7.6 26.6 1.4 1 0 0 1 1 1 0 Keratin type II head Pkinase PF00069.25 ETS62505.1 - 3.6e-43 147.8 0.0 4.6e-22 78.6 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62505.1 - 4.8e-12 45.7 0.0 5.2e-09 35.8 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 ETS62505.1 - 0.0025 17.8 0.0 0.0082 16.1 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETS62505.1 - 0.1 11.9 0.0 0.36 10.1 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ETS62505.1 - 0.14 11.7 0.0 0.31 10.6 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ETS62505.1 - 0.21 10.3 0.0 0.34 9.6 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase SAP18 PF06487.12 ETS62506.1 - 1e-27 97.0 0.0 1.5e-27 96.5 0.0 1.2 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Rad60-SLD PF11976.8 ETS62506.1 - 0.29 11.0 0.7 22 5.0 0.4 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_L7Ae PF01248.26 ETS62507.1 - 5.9e-28 96.5 0.8 7.4e-28 96.1 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_S17_N PF16205.5 ETS62508.1 - 1e-30 105.9 0.3 1e-30 105.9 0.3 1.7 2 0 0 2 2 2 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 ETS62508.1 - 6.7e-27 93.4 2.2 1.2e-26 92.6 2.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 DUF922 PF06037.11 ETS62508.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) Clathrin_lg_ch PF01086.17 ETS62509.1 - 1.3e-44 153.0 5.1 1.7e-44 152.6 5.1 1.1 1 0 0 1 1 1 1 Clathrin light chain Metallophos PF00149.28 ETS62510.1 - 1.7e-39 136.4 0.3 2.7e-39 135.8 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETS62510.1 - 0.0009 19.6 0.3 0.0017 18.7 0.3 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 ETS62510.1 - 0.14 12.3 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain FAD-oxidase_C PF02913.19 ETS62511.1 - 8.8e-64 215.5 0.0 1.4e-63 214.9 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ETS62511.1 - 3.1e-35 120.9 1.0 5.7e-35 120.1 1.0 1.5 1 0 0 1 1 1 1 FAD binding domain Ilar_coat PF01787.16 ETS62511.1 - 0.0078 16.0 0.2 0.29 10.9 0.0 2.7 3 0 0 3 3 3 1 Ilarvirus coat protein Cid2 PF09774.9 ETS62512.1 - 3e-37 128.5 0.2 4.2e-37 128.0 0.2 1.2 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Glyoxalase_6 PF18029.1 ETS62512.1 - 0.015 16.1 0.1 0.025 15.4 0.1 1.4 1 0 0 1 1 1 0 Glyoxalase-like domain Clathrin PF00637.20 ETS62513.1 - 2.6e-24 85.7 0.1 2.1e-23 82.8 0.0 2.3 2 0 0 2 2 2 1 Region in Clathrin and VPS TPR_14 PF13428.6 ETS62513.1 - 0.32 11.9 2.7 39 5.4 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETS62513.1 - 4.4 7.7 4.6 4.9 7.5 0.5 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat GRIM-19 PF06212.12 ETS62514.1 - 3.5e-35 120.8 0.0 6.5e-35 120.0 0.0 1.4 2 0 0 2 2 2 1 GRIM-19 protein Nop14 PF04147.12 ETS62515.1 - 0 1016.7 14.3 0 1016.4 14.3 1.0 1 0 0 1 1 1 1 Nop14-like family TIP41 PF04176.13 ETS62516.1 - 7e-48 162.4 0.0 4.7e-47 159.7 0.0 2.0 1 1 0 1 1 1 1 TIP41-like family zf-CCCH_4 PF18044.1 ETS62517.1 - 2.9e-09 36.5 2.5 5.5e-09 35.6 2.5 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETS62517.1 - 5.8e-06 26.2 6.5 1.1e-05 25.2 6.5 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ETS62517.1 - 1.9e-05 24.4 1.3 3.4e-05 23.6 1.3 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) TFIIA PF03153.13 ETS62517.1 - 0.1 12.6 18.9 0.16 12.0 18.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-CCCH_2 PF14608.6 ETS62517.1 - 0.3 11.6 6.2 0.55 10.8 6.2 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger PEHE PF15275.6 ETS62517.1 - 0.33 11.6 2.8 0.64 10.6 2.8 1.4 1 0 0 1 1 1 0 PEHE domain Roughex PF06020.11 ETS62517.1 - 1.7 7.7 3.4 2.6 7.1 3.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein SUIM_assoc PF16619.5 ETS62517.1 - 2.2 8.4 12.5 5.8 7.1 12.5 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 ETS62517.1 - 2.8 7.5 12.3 4.2 6.9 12.3 1.2 1 0 0 1 1 1 0 Spt20 family WD40 PF00400.32 ETS62518.1 - 1.4e-12 47.9 7.3 0.4 11.6 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62518.1 - 5.9e-06 26.5 0.0 0.079 13.3 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ETS62518.1 - 0.062 13.8 4.0 14 6.3 0.0 5.2 5 0 0 5 5 5 0 PQQ-like domain eIF2A PF08662.11 ETS62518.1 - 0.17 11.8 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A YccV-like PF08755.11 ETS62519.1 - 2.1e-17 63.4 0.0 6.1e-17 61.9 0.0 1.8 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Transglut_core2 PF13369.6 ETS62519.1 - 3.7e-13 49.3 0.0 1.2e-11 44.4 0.0 2.9 3 0 0 3 3 3 1 Transglutaminase-like superfamily F-box-like PF12937.7 ETS62519.1 - 3.4e-08 33.2 0.0 1.1e-07 31.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETS62519.1 - 3.3e-05 23.6 0.0 0.00013 21.8 0.0 2.0 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 ETS62519.1 - 0.048 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 F-box NOB1_Zn_bind PF08772.11 ETS62520.1 - 1.5e-31 108.3 1.9 3.1e-31 107.3 1.9 1.6 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 ETS62520.1 - 1.4e-25 89.6 0.0 3.5e-25 88.3 0.0 1.7 1 0 0 1 1 1 1 PIN domain of ribonuclease DZR PF12773.7 ETS62520.1 - 0.11 12.5 1.8 0.21 11.6 1.8 1.4 1 0 0 1 1 1 0 Double zinc ribbon XRN_M PF17846.1 ETS62520.1 - 4.5 6.1 5.0 9.3 5.1 5.0 1.6 1 0 0 1 1 1 0 Xrn1 helical domain Histone_HNS PF00816.21 ETS62520.1 - 5.9 7.8 18.5 0.056 14.3 8.2 2.9 3 0 0 3 3 3 0 H-NS histone family OGG_N PF07934.12 ETS62521.1 - 2.4e-26 92.2 0.0 5e-26 91.2 0.0 1.6 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 ETS62521.1 - 9.3e-15 55.0 0.0 2.1e-14 53.9 0.0 1.6 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ETS62521.1 - 0.0078 16.0 0.0 0.02 14.7 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif GLE1 PF07817.13 ETS62522.1 - 1.3e-77 260.4 0.1 1.9e-77 259.9 0.1 1.2 1 0 0 1 1 1 1 GLE1-like protein Casc1_N PF15927.5 ETS62522.1 - 0.009 15.7 6.7 0.009 15.7 6.7 2.4 1 1 1 2 2 2 1 Cancer susceptibility candidate 1 N-terminus AAA_23 PF13476.6 ETS62522.1 - 0.16 12.4 4.1 0.26 11.8 4.1 1.4 1 0 0 1 1 1 0 AAA domain Sec62 PF03839.16 ETS62522.1 - 0.7 9.4 2.7 1.5 8.3 2.7 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 KKLCAg1 PF15204.6 ETS62523.1 - 0.17 12.0 0.1 0.29 11.3 0.1 1.3 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 AAA PF00004.29 ETS62526.1 - 2.7e-92 306.1 0.0 2.6e-46 157.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS62526.1 - 9.9e-23 79.7 3.7 2.9e-11 43.0 1.0 2.7 2 1 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 ETS62526.1 - 1.1e-14 54.5 0.0 2.7e-07 30.5 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETS62526.1 - 1.2e-11 44.8 0.4 0.00048 20.1 0.2 4.4 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETS62526.1 - 1.1e-10 41.9 0.0 0.00055 20.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ETS62526.1 - 2.2e-10 41.2 8.9 0.00013 22.4 0.1 4.8 3 2 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 ETS62526.1 - 8.2e-10 39.1 1.6 0.026 14.8 0.0 4.8 2 2 2 5 5 4 2 AAA domain AAA_33 PF13671.6 ETS62526.1 - 1.6e-09 38.0 0.0 0.0029 17.8 0.0 3.4 3 0 0 3 3 3 2 AAA domain TIP49 PF06068.13 ETS62526.1 - 5.1e-09 35.8 0.4 0.00026 20.3 0.1 2.9 2 1 1 3 3 3 2 TIP49 P-loop domain Mg_chelatase PF01078.21 ETS62526.1 - 4.1e-07 29.6 0.4 0.034 13.5 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ETS62526.1 - 1.2e-06 28.6 0.0 0.021 14.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ETS62526.1 - 1.9e-06 28.2 0.0 0.071 13.5 0.0 2.5 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 ETS62526.1 - 4.2e-06 26.8 1.7 0.073 13.0 0.1 4.0 3 1 0 3 3 3 2 NACHT domain IstB_IS21 PF01695.17 ETS62526.1 - 4.4e-06 26.5 0.1 0.034 13.9 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein ABC_tran PF00005.27 ETS62526.1 - 9.9e-06 26.1 0.0 0.038 14.5 0.0 2.8 2 0 0 2 2 2 2 ABC transporter AAA_3 PF07726.11 ETS62526.1 - 1.9e-05 24.5 0.0 0.04 13.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ETS62526.1 - 1.9e-05 24.9 0.1 0.31 11.3 0.0 2.8 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 ETS62526.1 - 2.8e-05 24.1 0.0 0.33 11.0 0.0 2.3 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cytidylate_kin2 PF13189.6 ETS62526.1 - 4.2e-05 23.7 0.0 0.018 15.2 0.0 2.3 2 0 0 2 2 2 1 Cytidylate kinase-like family AAA_18 PF13238.6 ETS62526.1 - 8.9e-05 23.0 0.0 0.4 11.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ETS62526.1 - 0.00011 21.9 2.2 0.82 9.2 0.2 3.8 3 1 1 4 4 4 2 AAA domain ATPase PF06745.13 ETS62526.1 - 0.00012 21.5 0.1 1.4 8.2 0.0 3.4 3 0 0 3 3 3 1 KaiC Rad17 PF03215.15 ETS62526.1 - 0.0002 21.4 0.0 0.6 10.0 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_17 PF13207.6 ETS62526.1 - 0.00028 21.3 0.0 0.37 11.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETS62526.1 - 0.00031 20.3 0.0 0.54 9.7 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activat PF00158.26 ETS62526.1 - 0.00031 20.5 0.1 0.44 10.2 0.0 3.4 4 0 0 4 4 4 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 ETS62526.1 - 0.00039 19.8 0.2 0.65 9.2 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin Viral_helicase1 PF01443.18 ETS62526.1 - 0.00054 19.8 0.0 0.98 9.1 0.0 2.4 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_11 PF13086.6 ETS62526.1 - 0.0007 19.5 0.0 0.77 9.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 ETS62526.1 - 0.00087 18.5 0.0 0.84 8.8 0.0 2.7 3 0 0 3 3 3 1 NB-ARC domain DUF815 PF05673.13 ETS62526.1 - 0.0012 18.0 0.0 0.025 13.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Sigma54_activ_2 PF14532.6 ETS62526.1 - 0.0026 17.9 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AFG1_ATPase PF03969.16 ETS62526.1 - 0.0033 16.4 0.0 0.67 8.8 0.0 2.6 2 0 0 2 2 2 1 AFG1-like ATPase AAA_24 PF13479.6 ETS62526.1 - 0.0036 17.0 0.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 ETS62526.1 - 0.0053 16.2 0.4 2.3 7.6 0.0 2.7 3 0 0 3 3 3 1 PhoH-like protein Vps4_C PF09336.10 ETS62526.1 - 0.0055 16.7 0.1 1.7 8.7 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase_2 PF01637.18 ETS62526.1 - 0.015 15.3 0.0 1.9 8.3 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TniB PF05621.11 ETS62526.1 - 0.018 14.5 0.0 20 4.5 0.0 3.4 3 0 0 3 3 3 0 Bacterial TniB protein SKI PF01202.22 ETS62526.1 - 0.02 15.0 0.1 6.1 6.9 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase Parvo_NS1 PF01057.17 ETS62526.1 - 0.02 14.0 0.0 1.9 7.5 0.0 2.2 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 ETS62526.1 - 0.051 13.5 0.1 8.8 6.2 0.0 2.5 2 0 0 2 2 2 0 NTPase UBM PF14377.6 ETS62526.1 - 0.081 12.4 2.4 1.2 8.7 0.0 3.6 3 0 0 3 3 3 0 Ubiquitin binding region AAA_19 PF13245.6 ETS62526.1 - 0.095 13.0 0.9 13 6.1 0.0 2.9 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ETS62526.1 - 0.14 11.9 0.0 9.6 5.9 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.15 ETS62526.1 - 0.2 11.6 0.0 30 4.6 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit TB2_DP1_HVA22 PF03134.19 ETS62527.1 - 2e-08 34.0 0.8 3.7e-08 33.2 0.8 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Stathmin PF00836.19 ETS62527.1 - 0.075 13.0 0.8 0.24 11.4 0.8 1.8 1 0 0 1 1 1 0 Stathmin family IMS PF00817.20 ETS62528.1 - 2.4e-40 137.9 0.0 5e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ETS62528.1 - 9.6e-15 55.3 0.0 2.1e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain Cyt-b5 PF00173.28 ETS62528.1 - 3e-12 46.5 0.1 1.5e-08 34.7 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain UBM PF14377.6 ETS62528.1 - 2.7e-05 23.4 0.0 7.9e-05 22.0 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin binding region IMS_HHH PF11798.8 ETS62528.1 - 0.19 12.1 0.0 0.52 10.8 0.0 1.8 1 0 0 1 1 1 0 IMS family HHH motif CSN8_PSD8_EIF3K PF10075.9 ETS62530.1 - 1.1e-28 100.0 0.1 1.5e-28 99.5 0.1 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 ETS62530.1 - 5.3e-05 22.8 0.0 7.6e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 SAC3/GANP family Mus7 PF09462.10 ETS62531.1 - 0.18 10.6 0.9 5.6 5.7 0.0 2.1 2 0 0 2 2 2 0 Mus7/MMS22 family GBP_C PF02841.14 ETS62531.1 - 2.7 7.3 11.4 4.7 6.5 11.4 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain TRAPP PF04051.16 ETS62532.1 - 3.9e-33 114.2 0.0 6.3e-33 113.6 0.0 1.3 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component He_PIG PF05345.12 ETS62533.1 - 1.1e-09 38.3 15.7 0.00057 20.0 1.8 4.3 3 1 0 3 3 3 3 Putative Ig domain JHY PF15261.6 ETS62535.1 - 0.018 15.7 3.9 0.064 14.0 3.9 1.9 1 0 0 1 1 1 0 Jhy protein PP2C PF00481.21 ETS62536.1 - 9.9e-34 117.1 0.0 5.4e-30 104.9 0.0 2.9 2 1 1 3 3 3 2 Protein phosphatase 2C PP2C_2 PF13672.6 ETS62536.1 - 0.022 14.4 0.0 0.063 12.9 0.0 1.9 2 1 0 2 2 2 0 Protein phosphatase 2C BrkDBD PF09607.10 ETS62536.1 - 0.11 12.3 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Brinker DNA-binding domain NUDIX PF00293.28 ETS62537.1 - 4.3e-11 43.0 0.7 6.8e-11 42.3 0.7 1.3 1 0 0 1 1 1 1 NUDIX domain AAA PF00004.29 ETS62538.1 - 6.2e-54 182.0 0.0 8.3e-38 129.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 ETS62538.1 - 1e-10 41.2 0.7 1.4e-09 37.6 0.0 2.7 3 0 0 3 3 2 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 ETS62538.1 - 1.4e-09 38.5 0.3 0.0019 18.6 0.0 3.2 3 1 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 ETS62538.1 - 2.2e-09 37.7 0.9 0.0024 18.1 0.0 4.0 3 2 2 5 5 4 2 AAA domain AAA_lid_3 PF17862.1 ETS62538.1 - 2.6e-09 36.7 0.1 5.5e-09 35.7 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ETS62538.1 - 4.8e-08 33.1 0.0 0.002 18.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETS62538.1 - 6.3e-08 32.9 0.1 0.00043 20.4 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ETS62538.1 - 1.3e-07 31.5 0.3 0.011 15.5 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ETS62538.1 - 4.2e-07 29.5 0.0 0.0064 15.7 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain NACHT PF05729.12 ETS62538.1 - 4.3e-07 30.0 0.2 0.034 14.0 0.0 3.7 3 1 0 3 3 3 2 NACHT domain AAA_24 PF13479.6 ETS62538.1 - 6.3e-07 29.3 0.1 0.021 14.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ETS62538.1 - 1.2e-06 28.7 0.0 0.045 13.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain Mg_chelatase PF01078.21 ETS62538.1 - 1.6e-06 27.6 0.5 0.011 15.2 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ETS62538.1 - 6.1e-06 26.1 0.0 0.033 13.9 0.0 2.9 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 ETS62538.1 - 6.5e-06 26.5 0.0 0.031 14.7 0.0 2.6 2 0 0 2 2 2 2 RNA helicase ABC_tran PF00005.27 ETS62538.1 - 2.9e-05 24.6 0.6 0.19 12.2 0.1 3.3 3 0 0 3 3 3 1 ABC transporter AAA_18 PF13238.6 ETS62538.1 - 3.2e-05 24.5 0.0 0.067 13.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 ETS62538.1 - 4.1e-05 23.6 0.0 0.1 12.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 ETS62538.1 - 4.2e-05 23.6 0.4 0.78 9.6 0.2 3.7 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 ETS62538.1 - 5.1e-05 23.6 0.0 0.074 13.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 ETS62538.1 - 5.2e-05 23.2 0.0 0.16 12.0 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 ETS62538.1 - 7e-05 22.1 0.0 0.42 9.7 0.0 2.6 2 0 0 2 2 2 2 NB-ARC domain PhoH PF02562.16 ETS62538.1 - 0.00016 21.2 0.0 0.52 9.7 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_30 PF13604.6 ETS62538.1 - 0.00023 20.9 0.0 0.33 10.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 ETS62538.1 - 0.00031 20.5 0.0 0.65 9.7 0.0 2.6 2 1 0 2 2 2 2 Sigma-54 interaction domain ATPase PF06745.13 ETS62538.1 - 0.00048 19.5 0.1 0.13 11.5 0.0 2.5 2 0 0 2 2 2 1 KaiC Parvo_NS1 PF01057.17 ETS62538.1 - 0.00065 18.9 0.0 0.59 9.2 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 ETS62538.1 - 0.00083 19.0 2.2 0.9 9.1 0.0 3.3 3 1 0 4 4 3 2 AAA domain AAA_11 PF13086.6 ETS62538.1 - 0.00084 19.2 0.1 1.4 8.7 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 ETS62538.1 - 0.0009 18.8 0.1 0.2 11.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_19 PF13245.6 ETS62538.1 - 0.0025 18.2 0.9 1.6 9.1 0.1 2.9 3 0 0 3 3 2 1 AAA domain DUF2075 PF09848.9 ETS62538.1 - 0.0031 16.8 0.2 1.4 8.1 0.1 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 ETS62538.1 - 0.004 17.0 0.0 0.88 9.4 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ETS62538.1 - 0.0059 17.0 0.1 4.1 7.8 0.0 3.3 3 0 0 3 3 2 1 AAA domain DAP3 PF10236.9 ETS62538.1 - 0.013 14.7 0.0 4.6 6.3 0.0 2.4 2 1 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Zeta_toxin PF06414.12 ETS62538.1 - 0.016 14.5 0.1 0.49 9.6 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin cobW PF02492.19 ETS62538.1 - 0.053 13.1 0.1 5.4 6.6 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DEAD PF00270.29 ETS62538.1 - 0.055 13.2 1.3 32 4.3 0.0 3.8 2 2 2 4 4 4 0 DEAD/DEAH box helicase KTI12 PF08433.10 ETS62538.1 - 0.099 12.1 0.1 6.3 6.2 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 ResIII PF04851.15 ETS62538.1 - 0.12 12.4 0.1 47 3.9 0.0 3.4 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit NTPase_1 PF03266.15 ETS62538.1 - 0.14 12.1 0.1 18 5.2 0.0 2.7 2 0 0 2 2 2 0 NTPase Hydin_ADK PF17213.3 ETS62538.1 - 0.14 12.4 0.3 1.5 9.1 0.1 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain TCTP PF00838.17 ETS62539.1 - 4.4e-70 235.3 0.1 5.3e-70 235.1 0.1 1.1 1 0 0 1 1 1 1 Translationally controlled tumour protein Zn_clus PF00172.18 ETS62540.1 - 0.061 13.5 4.5 0.55 10.4 0.1 2.3 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PSI_integrin PF17205.3 ETS62540.1 - 0.64 9.8 3.0 10 5.9 0.1 2.4 2 0 0 2 2 2 0 Integrin plexin domain RasGAP PF00616.19 ETS62541.1 - 1.1e-22 80.8 0.0 4.6e-15 55.9 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ETS62541.1 - 3e-06 27.4 1.2 9e-06 25.9 0.1 2.3 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain ImpA_N PF06812.12 ETS62541.1 - 0.016 15.3 0.0 0.068 13.3 0.0 2.1 1 0 0 1 1 1 0 ImpA, N-terminal, type VI secretion system Zip PF02535.22 ETS62541.1 - 2.8 7.1 10.7 6.6 5.8 10.7 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter EF-hand_1 PF00036.32 ETS62542.1 - 3e-27 92.1 11.3 9e-08 31.1 0.3 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETS62542.1 - 1.3e-22 80.0 5.9 7.4e-13 48.7 0.9 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETS62542.1 - 1.9e-21 74.1 8.9 2e-05 24.2 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETS62542.1 - 1.5e-19 68.5 12.9 4.1e-07 29.2 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETS62542.1 - 1.4e-13 50.4 13.4 0.00041 20.1 0.4 4.3 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETS62542.1 - 5.4e-06 26.7 0.0 0.019 15.3 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETS62542.1 - 5.4e-06 26.6 0.0 0.17 12.3 0.1 3.1 2 1 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ETS62542.1 - 1.8e-05 24.6 6.3 0.0066 16.4 0.3 3.9 1 1 3 4 4 4 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ETS62542.1 - 0.11 12.7 3.6 2.1 8.6 3.1 2.8 2 1 0 2 2 2 0 Dockerin type I domain VCBS PF13517.6 ETS62542.1 - 0.14 12.8 1.1 15 6.3 0.1 2.5 2 1 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TM231 PF10149.9 ETS62542.1 - 0.16 11.3 0.3 0.24 10.7 0.3 1.3 1 0 0 1 1 1 0 Transmembrane protein 231 Proteasome PF00227.26 ETS62543.1 - 3.6e-42 144.0 0.2 4.1e-42 143.8 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit Vta1 PF04652.16 ETS62543.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Vta1 like Vac14_Fig4_bd PF11916.8 ETS62544.1 - 2.4e-79 265.1 8.5 2.4e-79 265.1 8.5 2.6 3 0 0 3 3 3 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 ETS62544.1 - 3.6e-44 149.3 0.0 1.3e-39 134.7 0.0 3.8 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ETS62544.1 - 1.8e-11 43.3 5.1 0.0019 18.3 0.0 6.2 6 0 0 6 6 6 2 HEAT repeat Cnd1 PF12717.7 ETS62544.1 - 8.6e-08 32.4 0.9 0.0058 16.7 0.4 3.5 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETS62544.1 - 5.9e-06 26.7 4.0 1.8 9.2 0.0 5.9 5 0 0 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 ETS62544.1 - 8.8e-05 22.8 9.3 0.47 10.9 0.0 5.8 5 2 1 6 6 5 2 HEAT repeats CLASP_N PF12348.8 ETS62544.1 - 0.00055 19.6 0.1 17 4.9 0.0 4.3 3 1 1 4 4 4 0 CLASP N terminal MMS19_C PF12460.8 ETS62544.1 - 0.001 18.3 5.7 0.031 13.4 0.0 3.3 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal CENP-B_dimeris PF09026.10 ETS62544.1 - 0.0072 16.7 2.6 0.016 15.6 2.6 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain TFIIE-A_C PF11521.8 ETS62544.1 - 0.028 14.7 2.4 0.079 13.3 2.4 1.7 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha ParcG PF10274.9 ETS62544.1 - 0.043 13.9 0.2 7.9 6.6 0.0 3.2 3 0 0 3 3 3 0 Parkin co-regulated protein Tti2 PF10521.9 ETS62544.1 - 0.1 12.1 3.0 4.5 6.7 0.0 3.9 4 1 1 5 5 5 0 Tti2 family Myc_N PF01056.18 ETS62544.1 - 0.11 12.3 5.1 0.27 11.1 5.1 1.5 1 0 0 1 1 1 0 Myc amino-terminal region Cwf_Cwc_15 PF04889.12 ETS62544.1 - 2.5 7.7 8.8 5.1 6.7 8.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein UCH PF00443.29 ETS62545.1 - 1.2e-48 165.9 0.0 1.9e-48 165.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS62545.1 - 2.5e-20 73.3 0.0 6.8e-14 52.2 0.0 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ETS62545.1 - 0.0012 18.4 0.0 0.013 15.0 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin-specific peptidase-like, SUMO isopeptidase Zn-ribbon_8 PF09723.10 ETS62545.1 - 0.14 12.3 0.6 18 5.6 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 ETS62545.1 - 0.28 11.3 1.9 1.3 9.1 1.9 1.9 1 1 1 2 2 2 0 Double zinc ribbon TBCA PF02970.16 ETS62546.1 - 1.2e-27 96.1 0.3 1.6e-27 95.6 0.3 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A PDEase_I PF00233.19 ETS62546.1 - 0.099 12.4 0.0 0.099 12.4 0.0 1.1 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Cpn60_TCP1 PF00118.24 ETS62548.1 - 5.5e-152 506.8 13.1 6.3e-152 506.6 13.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.18 ETS62548.1 - 0.0019 17.8 0.1 0.0062 16.1 0.1 1.9 2 0 0 2 2 2 1 Telomere recombination LSM PF01423.22 ETS62549.1 - 6.2e-21 73.9 0.0 6.9e-21 73.7 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ETS62549.1 - 0.0048 17.0 0.0 0.0056 16.8 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain MFS_2 PF13347.6 ETS62550.1 - 2.8e-10 39.3 7.7 4.6e-10 38.6 3.9 2.1 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_1 PF07690.16 ETS62550.1 - 5e-09 35.5 25.9 1.2e-08 34.3 12.1 2.5 2 0 0 2 2 2 2 Major Facilitator Superfamily zf-met2 PF12907.7 ETS62551.1 - 0.00076 19.6 0.5 0.00076 19.6 0.5 1.9 2 0 0 2 2 2 1 Zinc-binding zf-Di19 PF05605.12 ETS62551.1 - 0.0027 18.0 2.4 0.0047 17.2 2.4 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf_C2H2_ZHX PF18387.1 ETS62551.1 - 0.012 15.2 1.0 0.02 14.5 0.3 1.6 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_9 PF16293.5 ETS62551.1 - 0.25 11.2 0.7 0.81 9.6 0.3 1.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) MDM31_MDM32 PF08118.11 ETS62552.1 - 8.9e-190 631.8 0.0 1.7e-189 630.9 0.0 1.4 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Peptidase_M24 PF00557.24 ETS62553.1 - 4.8e-44 150.6 0.0 6.6e-44 150.1 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N_2 PF16189.5 ETS62553.1 - 6.2e-42 143.4 0.0 1.1e-40 139.4 0.0 2.4 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 ETS62553.1 - 1.8e-16 59.9 0.1 4.5e-16 58.7 0.1 1.7 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ETS62553.1 - 6.5e-16 59.2 0.4 3.9e-14 53.4 0.0 3.0 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Pirin_C_2 PF17954.1 ETS62553.1 - 0.14 12.4 0.0 3.9 7.7 0.0 2.5 2 0 0 2 2 2 0 Quercetinase C-terminal cupin domain Glyoxal_oxid_N PF07250.11 ETS62555.1 - 1.3e-29 103.1 2.4 3.2e-16 59.3 0.1 5.0 2 2 2 4 4 4 2 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ETS62555.1 - 9e-20 70.8 0.3 2.1e-19 69.6 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Ribosomal_L11_N PF03946.14 ETS62556.1 - 2.5e-23 81.7 0.1 4.1e-23 81.0 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ETS62556.1 - 3.9e-17 62.5 0.5 7.5e-17 61.6 0.5 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain HnRNP_M PF11532.8 ETS62556.1 - 0.013 15.7 0.8 0.022 14.9 0.8 1.3 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein M WD40 PF00400.32 ETS62557.1 - 3.4e-43 144.8 20.5 4.4e-08 33.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62557.1 - 9.2e-12 45.1 0.6 0.017 15.4 0.0 4.9 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS62557.1 - 3.8e-05 22.5 5.0 0.017 13.8 0.2 3.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 DUF1513 PF07433.11 ETS62557.1 - 0.0076 15.4 0.0 0.44 9.6 0.0 2.9 2 2 1 3 3 3 1 Protein of unknown function (DUF1513) PD40 PF07676.12 ETS62557.1 - 0.0083 16.0 2.6 25 5.0 0.0 5.3 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETS62557.1 - 0.022 13.3 0.1 0.46 9.0 0.2 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain JUPITER PF17054.5 ETS62557.1 - 0.055 12.9 0.0 0.071 12.6 0.0 1.1 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Thymidylat_synt PF00303.19 ETS62558.1 - 2e-109 364.8 0.0 3.5e-109 364.1 0.0 1.4 1 0 0 1 1 1 1 Thymidylate synthase His_Phos_1 PF00300.22 ETS62558.1 - 7.5e-38 130.2 0.1 2.8e-37 128.3 0.1 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Sec23_trunk PF04811.15 ETS62559.1 - 1.2e-58 198.6 0.0 3.7e-58 197.0 0.0 1.7 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ETS62559.1 - 8.8e-23 80.1 0.0 1.5e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ETS62559.1 - 1.5e-19 70.5 0.0 3.1e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ETS62559.1 - 2.3e-16 59.6 2.8 4.4e-16 58.6 2.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ETS62559.1 - 0.0021 17.9 0.0 0.005 16.7 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat peroxidase PF00141.23 ETS62560.1 - 4.1e-46 157.5 0.0 6.8e-46 156.8 0.0 1.3 1 0 0 1 1 1 1 Peroxidase UPF0139 PF03669.13 ETS62563.1 - 0.00035 20.4 0.0 0.00059 19.6 0.0 1.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0139) CBP4 PF07960.11 ETS62564.1 - 2.2e-12 46.9 0.0 2.7e-12 46.7 0.0 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 ETS62564.1 - 0.042 13.8 0.0 0.044 13.7 0.0 1.1 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Sugar_tr PF00083.24 ETS62565.1 - 5.4e-78 262.9 11.7 6.6e-78 262.6 11.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS62565.1 - 1e-19 70.7 14.9 1e-19 70.7 14.9 2.3 1 1 1 2 2 2 1 Major Facilitator Superfamily 7tm_2 PF00002.24 ETS62565.1 - 3.6 6.8 8.5 0.2 10.9 0.7 2.5 4 0 0 4 4 4 0 7 transmembrane receptor (Secretin family) HEAT PF02985.22 ETS62566.1 - 4.5e-19 66.9 18.7 0.00012 22.0 0.0 11.2 12 0 0 12 12 12 4 HEAT repeat HEAT_EZ PF13513.6 ETS62566.1 - 1.1e-14 54.6 20.1 2.6e-09 37.4 0.0 8.4 8 2 2 10 10 10 4 HEAT-like repeat HEAT_2 PF13646.6 ETS62566.1 - 3.4e-10 40.2 15.7 0.0013 19.1 0.0 6.9 3 2 5 8 8 8 6 HEAT repeats IBN_N PF03810.19 ETS62566.1 - 2.1e-08 34.0 1.1 6.5e-07 29.2 0.0 3.4 3 0 0 3 3 3 1 Importin-beta N-terminal domain Arm PF00514.23 ETS62566.1 - 1.4e-07 31.3 9.4 0.015 15.3 0.0 5.5 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 ETS62566.1 - 0.00048 20.2 0.0 0.0046 17.0 0.0 2.7 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETS62566.1 - 0.0049 15.5 0.3 0.19 10.2 0.0 3.3 3 2 2 5 5 5 1 Adaptin N terminal region HEAT_PBS PF03130.16 ETS62566.1 - 0.019 15.6 4.6 30 5.7 0.0 5.7 5 0 0 5 5 5 0 PBS lyase HEAT-like repeat CLASP_N PF12348.8 ETS62566.1 - 0.045 13.3 0.1 42 3.6 0.0 3.9 4 1 1 5 5 5 0 CLASP N terminal TIP120 PF08623.10 ETS62566.1 - 0.047 13.5 0.8 1.1 9.0 0.0 3.1 3 0 0 3 3 3 0 TATA-binding protein interacting (TIP20) Mfa1 PF17445.2 ETS62567.1 - 1.1e-11 44.5 2.4 2e-11 43.7 2.4 1.4 1 0 0 1 1 1 1 Mating factor A1 STE3 PF02076.15 ETS62568.1 - 1.5e-74 250.8 15.0 1.7e-74 250.6 15.0 1.0 1 0 0 1 1 1 1 Pheromone A receptor Stealth_CR2 PF11380.8 ETS62569.1 - 5.4e-16 58.7 0.0 3.9e-09 36.7 0.0 3.0 3 0 0 3 3 3 2 Stealth protein CR2, conserved region 2 Stealth_CR4 PF17103.5 ETS62569.1 - 6.6e-06 25.9 0.0 1.5e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 ETS62569.1 - 0.0094 15.8 1.1 0.026 14.4 0.1 2.4 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 ETS62569.1 - 0.12 12.2 0.4 0.3 10.8 0.4 1.7 1 0 0 1 1 1 0 Stealth protein CR1, conserved region 1 Sen15 PF09631.10 ETS62570.1 - 6.8e-13 48.8 0.0 1.3e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Sen15 protein Polysacc_deac_1 PF01522.21 ETS62571.1 - 1.5e-05 24.9 0.0 2.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DAHP_synth_1 PF00793.20 ETS62572.1 - 4.9e-99 330.7 0.0 5.7e-99 330.4 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Ribosomal_S19 PF00203.21 ETS62573.1 - 4.1e-26 90.7 0.0 5.1e-26 90.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 OPT PF03169.15 ETS62574.1 - 3.3e-150 501.7 40.8 3.8e-150 501.5 40.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DEC-1_N PF04625.13 ETS62575.1 - 0.025 13.6 0.4 0.027 13.5 0.4 1.1 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region P16-Arc PF04699.14 ETS62576.1 - 7.9e-46 156.2 0.0 8.8e-46 156.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) DUF1296 PF06972.11 ETS62576.1 - 0.077 13.1 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) Fungal_trans PF04082.18 ETS62577.1 - 1.3e-11 44.0 0.0 2.2e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS62577.1 - 3.4e-06 27.1 8.8 6e-06 26.3 8.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ArfGap PF01412.18 ETS62582.1 - 1e-35 122.3 0.7 2.1e-35 121.3 0.7 1.5 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 ETS62582.1 - 3e-10 40.6 0.0 5.9e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 PH domain BAR_3 PF16746.5 ETS62582.1 - 0.00037 20.3 2.6 0.00094 19.0 1.8 2.1 1 1 1 2 2 2 1 BAR domain of APPL family tRNA-synt_1c PF00749.21 ETS62583.1 - 1.5e-78 263.9 0.0 1.9e-78 263.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Rft-1 PF04506.13 ETS62584.1 - 4.7e-106 355.6 2.5 3.3e-105 352.8 2.5 1.9 1 1 0 1 1 1 1 Rft protein COQ7 PF03232.13 ETS62584.1 - 0.18 11.6 0.0 4 7.2 0.0 2.5 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 HNH_3 PF13392.6 ETS62586.1 - 0.026 14.3 2.5 0.06 13.1 2.5 1.6 1 1 0 1 1 1 0 HNH endonuclease Kelch_5 PF13854.6 ETS62587.1 - 1.2e-14 53.8 0.2 0.00066 19.6 0.0 5.8 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETS62587.1 - 3.6e-11 42.9 0.8 0.0004 20.3 0.0 4.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETS62587.1 - 5.3e-11 42.5 5.6 0.018 15.3 0.1 5.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ETS62587.1 - 6.2e-06 25.7 0.0 0.29 10.7 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETS62587.1 - 1e-05 25.7 0.9 1 9.7 0.0 4.6 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETS62587.1 - 0.016 15.2 0.0 0.2 11.7 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Gram_pos_anchor PF00746.21 ETS62587.1 - 6.5 6.8 7.8 0.3 11.1 0.6 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Peptidase_M3 PF01432.20 ETS62588.1 - 4.9e-118 395.3 0.0 6.8e-118 394.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 PhoLip_ATPase_C PF16212.5 ETS62589.1 - 8.2e-51 173.1 20.5 8.2e-51 173.1 20.5 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ETS62589.1 - 4.3e-19 68.0 2.2 1e-18 66.8 2.2 1.6 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ETS62589.1 - 9.2e-14 52.2 0.6 6.8e-08 33.1 0.6 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS62589.1 - 1.3e-09 38.0 0.0 4.1e-08 33.2 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ETS62589.1 - 7.3e-09 35.4 10.7 0.00019 21.0 0.1 3.1 3 0 0 3 3 3 2 E1-E2 ATPase Hydrolase_3 PF08282.12 ETS62589.1 - 0.011 15.4 0.1 0.027 14.2 0.1 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Complex1_LYR_2 PF13233.6 ETS62590.1 - 0.00045 20.9 0.0 0.001 19.7 0.0 1.6 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ETS62590.1 - 0.00057 19.9 0.2 0.0012 18.9 0.2 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) zf-C2H2_2 PF12756.7 ETS62591.1 - 4.7e-34 116.8 5.3 2.2e-27 95.4 0.0 3.3 2 1 1 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ETS62591.1 - 6.2e-12 45.5 16.6 1.1e-09 38.3 2.9 4.5 4 1 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETS62591.1 - 6.9e-10 39.0 4.9 5.8e-09 36.0 2.5 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ETS62591.1 - 6e-05 23.6 11.3 0.2 12.6 0.1 4.6 4 0 0 4 4 4 3 C2H2-type zinc finger zf-DBF PF07535.12 ETS62591.1 - 0.021 14.9 3.6 0.029 14.5 0.6 2.5 2 0 0 2 2 2 0 DBF zinc finger zf-C2H2 PF00096.26 ETS62591.1 - 0.032 14.7 17.1 0.26 11.8 0.3 4.3 4 1 0 4 4 4 0 Zinc finger, C2H2 type DUF5114 PF17141.4 ETS62591.1 - 0.091 13.3 0.1 0.88 10.1 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5114) zf-H2C2_2 PF13465.6 ETS62591.1 - 0.19 12.2 7.2 10 6.7 0.7 3.8 3 0 0 3 3 3 0 Zinc-finger double domain Ribosomal_L40e PF01020.17 ETS62592.1 - 1.8e-30 104.6 9.4 2.7e-30 104.0 9.4 1.3 1 0 0 1 1 1 1 Ribosomal L40e family ubiquitin PF00240.23 ETS62592.1 - 1.8e-20 72.4 3.1 1.5e-14 53.5 0.2 2.2 1 1 1 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETS62592.1 - 1.2e-08 34.7 0.4 9.8e-06 25.3 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 ETS62592.1 - 0.022 14.8 0.0 0.028 14.5 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like EF1G PF00647.19 ETS62593.1 - 4.4e-45 152.1 0.0 8e-45 151.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 ETS62593.1 - 1e-16 61.0 0.0 4.5e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ETS62593.1 - 1.2e-11 44.7 0.0 3.1e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain CPDase PF07823.11 ETS62593.1 - 3.6e-11 43.2 0.0 6e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein GST_N_3 PF13417.6 ETS62593.1 - 2.8e-08 34.0 0.0 6e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETS62593.1 - 8.7e-08 32.1 0.0 2.5e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETS62593.1 - 1.8e-06 28.1 0.1 7.2e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ETS62593.1 - 1.2e-05 25.5 0.0 3.9e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain 2_5_RNA_ligase2 PF13563.6 ETS62593.1 - 0.029 14.3 0.2 0.065 13.1 0.2 1.6 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily Thioredoxin PF00085.20 ETS62594.1 - 1.4e-60 201.7 0.6 1.2e-30 105.5 0.0 3.9 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 ETS62594.1 - 7.4e-35 120.5 0.6 2.5e-26 92.7 0.1 3.1 2 1 1 3 3 3 2 Thioredoxin-like domain Calsequestrin PF01216.17 ETS62594.1 - 3.4e-10 39.5 0.8 5.9e-10 38.7 0.8 1.3 1 0 0 1 1 1 1 Calsequestrin Thioredoxin_2 PF13098.6 ETS62594.1 - 2.7e-08 34.2 0.9 0.054 14.0 0.1 4.3 3 2 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ETS62594.1 - 3.4e-08 33.7 0.1 0.024 14.9 0.0 4.6 4 1 1 5 5 5 2 Thioredoxin-like OST3_OST6 PF04756.13 ETS62594.1 - 4.5e-07 29.5 0.1 0.032 13.6 0.0 2.7 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 ETS62594.1 - 8.7e-07 29.0 0.0 0.034 14.3 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like AhpC-TSA PF00578.21 ETS62594.1 - 1.6e-06 28.1 0.0 0.1 12.5 0.0 2.8 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_4 PF13462.6 ETS62594.1 - 0.00016 21.9 1.7 0.58 10.3 0.2 3.0 2 1 0 2 2 2 2 Thioredoxin Redoxin PF08534.10 ETS62594.1 - 0.0012 18.5 2.9 0.18 11.5 0.0 3.2 3 0 0 3 3 3 1 Redoxin TraF PF13728.6 ETS62594.1 - 0.01 15.7 0.0 0.16 11.7 0.0 2.5 2 0 0 2 2 2 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 ETS62594.1 - 0.022 14.8 0.0 0.7 10.0 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin domain ANAPC1 PF12859.7 ETS62595.1 - 1.6e-18 67.5 0.3 9.3e-18 65.0 0.3 2.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 1 APC1_C PF18122.1 ETS62595.1 - 1.3e-11 44.8 0.2 3.1e-11 43.5 0.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex sub unit 1 C-terminal domain PC_rep PF01851.22 ETS62595.1 - 3e-09 36.8 14.6 0.71 10.4 0.1 6.4 6 0 0 6 6 6 5 Proteasome/cyclosome repeat OAR PF03826.17 ETS62595.1 - 0.092 12.6 0.3 0.31 10.9 0.3 2.0 1 0 0 1 1 1 0 OAR domain UQ_con PF00179.26 ETS62596.1 - 1.2e-44 151.3 0.0 1.6e-44 151.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETS62596.1 - 0.092 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B CAF1 PF04857.20 ETS62597.1 - 1.1e-21 77.3 0.0 1.4e-10 40.9 0.0 2.4 2 1 0 2 2 2 2 CAF1 family ribonuclease VWA_2 PF13519.6 ETS62598.1 - 2.6e-26 92.4 0.1 9e-26 90.6 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETS62598.1 - 4.2e-10 40.1 0.1 7.8e-10 39.3 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 ETS62598.1 - 6.1e-10 39.2 0.0 8.8e-10 38.7 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 ETS62598.1 - 1.2e-06 28.0 32.8 9.2e-05 22.1 4.0 4.6 5 0 0 5 5 5 3 Ubiquitin interaction motif YjeF_N PF03853.15 ETS62598.1 - 0.019 14.8 0.5 0.041 13.8 0.1 1.7 2 0 0 2 2 2 0 YjeF-related protein N-terminus RAP80_UIM PF18282.1 ETS62598.1 - 0.086 12.6 10.4 0.52 10.1 0.0 3.4 4 0 0 4 4 4 0 RAP80 N-terminal ubiquitin interaction motif zf-RanBP PF00641.18 ETS62599.1 - 0.00042 19.6 3.0 0.00086 18.6 3.0 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF35_N PF12172.8 ETS62599.1 - 0.35 10.8 4.7 0.95 9.4 4.7 1.7 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RhoGEF PF00621.20 ETS62600.1 - 1.5e-39 136.1 0.3 2.7e-39 135.3 0.3 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 ETS62600.1 - 5.9e-39 133.1 0.0 1.2e-38 132.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 ETS62600.1 - 2.8e-34 117.2 0.0 5.1e-34 116.4 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.24 ETS62600.1 - 3.8e-08 33.2 0.0 9.7e-08 31.9 0.0 1.7 1 0 0 1 1 1 1 PB1 domain CH PF00307.31 ETS62600.1 - 0.0083 16.3 0.0 0.021 15.0 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain AIM3 PF17096.5 ETS62601.1 - 1.3 10.0 6.9 0.15 13.0 1.5 2.1 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 3 IFT57 PF10498.9 ETS62603.1 - 0.39 9.6 21.6 0.49 9.3 21.6 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 IMD PF08397.11 ETS62603.1 - 0.75 9.1 18.7 1.1 8.6 18.7 1.2 1 0 0 1 1 1 0 IRSp53/MIM homology domain Atg14 PF10186.9 ETS62603.1 - 1.8 7.6 18.8 2.1 7.3 18.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 ETS62603.1 - 2.2 8.4 34.6 0.65 10.1 31.1 1.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein V_ATPase_I PF01496.19 ETS62603.1 - 3.2 5.5 16.6 3.8 5.3 16.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fasciclin PF02469.22 ETS62603.1 - 6.3 7.0 11.8 2.7 8.2 7.7 2.0 1 1 1 2 2 2 0 Fasciclin domain Borrelia_P83 PF05262.11 ETS62603.1 - 9 4.6 32.8 11 4.4 32.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein ASF1_hist_chap PF04729.13 ETS62604.1 - 6.8e-69 230.7 0.1 7.7e-69 230.5 0.1 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Dus PF01207.17 ETS62605.1 - 2.2e-42 145.2 0.0 2.9e-22 79.1 0.0 3.1 3 0 0 3 3 3 3 Dihydrouridine synthase (Dus) ZT_dimer PF16916.5 ETS62605.1 - 0.19 11.8 0.0 0.37 11.0 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter Zn_clus PF00172.18 ETS62607.1 - 6.7e-09 35.7 11.4 1.2e-08 34.9 11.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain eIF-5a PF01287.20 ETS62608.1 - 5.5e-30 103.3 0.3 7.9e-30 102.8 0.3 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 ETS62608.1 - 0.089 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain HLH PF00010.26 ETS62609.1 - 8.3e-13 48.1 0.2 1.5e-12 47.2 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TolA_bind_tri PF16331.5 ETS62609.1 - 0.0077 16.3 0.4 0.024 14.7 0.4 1.8 1 0 0 1 1 1 1 TolA binding protein trimerisation DUF3450 PF11932.8 ETS62609.1 - 0.072 12.4 0.2 0.072 12.4 0.2 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) EMC1_C PF07774.13 ETS62610.1 - 2.4e-64 216.9 0.0 5.4e-64 215.8 0.0 1.7 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 ETS62610.1 - 3e-10 40.1 6.1 3.9e-07 29.9 0.7 3.7 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 ETS62610.1 - 0.0014 18.5 0.1 9.8 6.3 0.0 4.5 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_3 PF13570.6 ETS62610.1 - 0.85 10.2 5.2 9.9 6.8 0.0 5.1 5 0 0 5 5 5 0 PQQ-like domain Zn_clus PF00172.18 ETS62611.1 - 1.1e-08 35.0 10.8 2e-08 34.2 10.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS62611.1 - 0.029 13.4 0.0 0.055 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain RNA_pol_Rpb2_6 PF00562.28 ETS62612.1 - 8.1e-118 393.9 0.2 9.4e-118 393.7 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 ETS62612.1 - 5.5e-31 106.8 0.2 1.2e-30 105.7 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RecR PF02132.15 ETS62612.1 - 0.074 12.6 0.2 0.15 11.7 0.2 1.5 1 0 0 1 1 1 0 RecR protein RNA_pol_Rpb2_1 PF04563.15 ETS62613.1 - 1.2e-60 204.6 0.1 1.6e-60 204.1 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 ETS62613.1 - 3.6e-36 124.6 0.3 7.6e-36 123.5 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 ETS62613.1 - 1.9e-26 92.1 3.8 2.4e-26 91.8 1.4 2.3 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 ETS62613.1 - 2.4e-20 72.5 0.0 5.8e-20 71.2 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 ETS62613.1 - 2.5e-12 47.2 1.0 1.7e-11 44.5 0.2 2.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 Metallophos PF00149.28 ETS62614.1 - 5.6e-36 125.0 0.0 8.6e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 ETS62614.1 - 0.0079 15.9 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain STPPase_N PF16891.5 ETS62614.1 - 0.066 13.7 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain TAD2 PF18521.1 ETS62614.1 - 0.22 11.6 1.9 0.25 11.4 0.2 2.0 2 0 0 2 2 2 0 Transactivation domain 2 RrnaAD PF00398.20 ETS62615.1 - 3.3e-60 203.4 0.0 4.2e-60 203.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ETS62615.1 - 2.4e-06 28.1 0.0 4.7e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS62615.1 - 0.00015 22.4 0.0 0.00032 21.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS62615.1 - 0.0011 18.5 0.0 0.0018 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ETS62615.1 - 0.003 18.3 0.0 0.0061 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ETS62615.1 - 0.0052 16.1 0.0 0.0082 15.5 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 ETS62615.1 - 0.0065 16.3 0.0 0.01 15.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETS62615.1 - 0.0087 15.4 0.0 0.021 14.2 0.0 1.5 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PCMT PF01135.19 ETS62615.1 - 0.011 15.4 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_28 PF02636.17 ETS62615.1 - 0.014 15.1 0.0 0.028 14.1 0.0 1.5 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase NodS PF05401.11 ETS62615.1 - 0.019 14.6 0.0 0.034 13.8 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 ETS62615.1 - 0.11 11.8 0.0 0.19 11.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Adaptin_N PF01602.20 ETS62616.1 - 1.2e-140 469.6 5.5 1.6e-140 469.2 5.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETS62616.1 - 2.6e-62 209.6 0.8 2.4e-58 196.8 0.1 2.6 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETS62616.1 - 7.7e-17 61.5 5.1 1.8e-05 25.1 0.1 6.0 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 ETS62616.1 - 5.2e-10 38.7 0.7 0.01 16.0 0.0 5.7 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 ETS62616.1 - 1.2e-05 25.7 1.6 0.12 13.0 0.0 6.5 6 2 1 7 7 7 1 HEAT-like repeat Cnd3 PF12719.7 ETS62616.1 - 0.0011 18.3 0.1 0.21 10.7 0.3 2.7 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 ETS62616.1 - 0.0022 17.6 0.1 2.3 7.7 0.0 2.9 3 0 0 3 3 3 2 CLASP N terminal Sec7_N PF12783.7 ETS62616.1 - 0.021 14.8 0.5 0.12 12.2 0.1 2.3 1 1 1 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Lyase_1 PF00206.20 ETS62617.1 - 2.7e-23 82.9 0.0 4.2e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 ETS62617.1 - 3.9e-18 65.8 0.1 1.1e-17 64.3 0.1 1.9 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus Adaptin_binding PF10199.9 ETS62618.1 - 5.9e-21 75.3 0.0 2.5e-20 73.3 0.0 2.1 2 1 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 Sod_Fe_C PF02777.18 ETS62619.1 - 4.3e-35 119.9 0.1 7e-35 119.3 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ETS62619.1 - 1.2e-31 109.0 4.1 1.4e-31 108.8 2.8 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Mus7 PF09462.10 ETS62620.1 - 4.1e-156 521.4 0.0 5.6e-156 521.0 0.0 1.2 1 0 0 1 1 1 1 Mus7/MMS22 family DUF4674 PF15719.5 ETS62620.1 - 3.7 7.6 7.9 5.6 7.0 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4674) RPN13_C PF16550.5 ETS62621.1 - 0.033 14.4 1.4 0.16 12.1 0.4 2.5 2 1 0 2 2 2 0 UCH-binding domain Syntaxin-6_N PF09177.11 ETS62621.1 - 1.8 9.2 6.1 1.3 9.7 0.2 3.1 3 2 0 3 3 3 0 Syntaxin 6, N-terminal Membr_traf_MHD PF10540.9 ETS62622.1 - 4.1e-15 56.2 1.3 4.1e-07 30.3 0.5 2.9 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 ETS62622.1 - 5.3e-10 39.5 0.0 1.1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 ETS62622.1 - 9.2e-06 24.5 1.7 9.8e-06 24.4 0.4 1.7 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) Myb_DNA-bind_4 PF13837.6 ETS62623.1 - 0.077 13.4 1.2 0.17 12.3 0.2 2.1 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain Aa_trans PF01490.18 ETS62624.1 - 8.1e-18 64.3 38.9 1.1e-17 63.9 38.9 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein F-box-like PF12937.7 ETS62625.1 - 6.9e-12 45.1 0.1 1.5e-11 44.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like DUF3506 PF12014.8 ETS62625.1 - 9.9e-11 41.8 0.0 2.9e-10 40.3 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3506) F-box PF00646.33 ETS62625.1 - 0.00018 21.3 0.0 0.00048 19.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ETS62625.1 - 0.00075 19.4 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 F-box Ras PF00071.22 ETS62626.1 - 6.2e-59 198.2 0.1 7.3e-59 198.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS62626.1 - 1.4e-35 122.1 0.0 2.4e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS62626.1 - 1.3e-12 47.5 0.0 1.6e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS62626.1 - 8.1e-06 25.5 0.0 1.2e-05 25.0 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETS62626.1 - 8.2e-06 25.3 0.0 1e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS62626.1 - 9.4e-06 25.7 0.0 1.5e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS62626.1 - 3.3e-05 23.9 1.3 0.16 11.8 0.1 2.5 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 ETS62626.1 - 0.006 17.0 1.4 0.041 14.3 1.4 2.1 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 ETS62626.1 - 0.0078 15.6 0.0 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 ETS62626.1 - 0.018 15.3 0.1 3.1 8.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.10 ETS62626.1 - 0.1 12.0 0.1 0.31 10.4 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NIF3 PF01784.18 ETS62627.1 - 1.7e-64 217.8 0.0 2.1e-64 217.5 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) COPIIcoated_ERV PF07970.12 ETS62628.1 - 5.3e-38 131.1 0.1 1.1e-37 130.1 0.1 1.4 1 1 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ETS62628.1 - 3e-26 91.6 0.1 5.4e-26 90.8 0.1 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) CST-I PF06002.12 ETS62628.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) RNA_pol_A_bac PF01000.26 ETS62629.1 - 4e-28 98.0 0.0 7e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ETS62629.1 - 1e-20 72.9 0.0 1.7e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DUF4775 PF16001.5 ETS62629.1 - 0.021 14.3 0.8 0.03 13.8 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Peptidase_C65 PF10275.9 ETS62630.1 - 1.3e-76 257.3 0.0 1.6e-76 257.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 ETS62630.1 - 0.027 15.0 0.0 6.1 7.3 0.0 2.3 2 0 0 2 2 2 0 OTU-like cysteine protease Rv2175c_C PF18367.1 ETS62630.1 - 0.1 12.7 0.1 0.34 11.0 0.1 1.9 1 0 0 1 1 1 0 Rv2175c C-terminal domain of unknown function Fungal_trans PF04082.18 ETS62631.1 - 1.4e-11 43.9 0.3 2.8e-11 43.0 0.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS62631.1 - 4.3e-05 23.5 11.0 6.7e-05 22.9 11.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pyr_redox_2 PF07992.14 ETS62632.1 - 3.1e-65 220.3 6.5 3.1e-65 220.3 6.5 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETS62632.1 - 5.3e-42 142.5 2.4 6.2e-42 142.3 0.4 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ETS62632.1 - 1.1e-18 67.5 8.4 9.2e-16 58.2 2.0 3.5 4 0 0 4 4 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ETS62632.1 - 1e-10 41.6 0.3 1e-10 41.6 0.3 2.9 2 1 1 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS62632.1 - 1e-10 41.4 6.0 9.7e-08 31.6 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETS62632.1 - 2.4e-08 33.5 8.4 1e-06 28.1 3.9 2.9 2 1 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ETS62632.1 - 2.1e-07 31.1 4.4 0.00013 22.1 0.5 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETS62632.1 - 4.2e-07 29.4 1.9 4.2e-07 29.4 1.9 3.6 3 1 1 4 4 4 1 FAD binding domain HI0933_like PF03486.14 ETS62632.1 - 2e-06 26.8 12.9 0.00063 18.6 0.8 4.0 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.17 ETS62632.1 - 3.2e-06 26.6 3.7 0.0018 17.5 0.1 2.4 2 0 0 2 2 2 2 Thi4 family AlaDh_PNT_C PF01262.21 ETS62632.1 - 4.4e-06 26.1 3.5 0.012 14.9 0.4 2.6 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain K_oxygenase PF13434.6 ETS62632.1 - 8e-06 25.2 0.4 0.15 11.2 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 ETS62632.1 - 2e-05 24.0 9.0 0.064 12.5 0.1 3.3 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 ETS62632.1 - 0.022 14.3 13.3 0.57 9.7 0.1 3.9 3 1 0 4 4 4 0 FAD dependent oxidoreductase Mqo PF06039.15 ETS62632.1 - 0.069 11.7 2.0 0.17 10.4 0.2 2.0 1 1 1 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Lycopene_cycl PF05834.12 ETS62632.1 - 0.32 10.0 3.2 1.2 8.1 0.1 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein 3HCDH_N PF02737.18 ETS62632.1 - 2.9 7.7 6.8 0.23 11.3 1.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GluRS_N PF18466.1 ETS62632.1 - 3.3 8.2 6.7 7 7.1 0.5 3.3 4 0 0 4 4 4 0 Glutamate--tRNA ligase N-terminal domain UQ_con PF00179.26 ETS62633.1 - 7.4e-36 122.9 0.0 9.6e-36 122.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Ribosomal_L18A PF01775.17 ETS62634.1 - 3e-51 172.6 1.3 3.7e-51 172.3 1.3 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A PWI PF01480.17 ETS62635.1 - 2.2e-09 37.5 0.0 3.6e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 PWI domain Nup35_RRM_2 PF14605.6 ETS62635.1 - 1.8e-07 31.1 0.0 0.0019 18.1 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif zf-CCCH PF00642.24 ETS62635.1 - 2e-06 27.5 4.6 3.5e-06 26.8 4.6 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 ETS62635.1 - 6.4e-05 22.7 0.1 0.46 10.4 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 ETS62635.1 - 9.9e-05 22.3 6.8 0.00018 21.4 6.8 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 ETS62635.1 - 0.016 15.0 4.5 0.028 14.2 4.5 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Torus PF16131.5 ETS62635.1 - 0.024 15.4 0.1 0.058 14.1 0.1 1.7 1 0 0 1 1 1 0 Torus domain Seryl_tRNA_N PF02403.22 ETS62635.1 - 0.25 11.6 14.2 0.05 13.8 6.2 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain MCRS_N PF13325.6 ETS62635.1 - 4 7.4 6.5 0.43 10.6 0.4 2.1 2 0 0 2 2 2 0 N-terminal region of micro-spherule protein zf-CCCH_2 PF14608.6 ETS62635.1 - 4.6 7.9 5.6 8 7.1 5.6 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger COX5A PF02284.16 ETS62636.1 - 7.3e-41 138.4 0.1 1.1e-40 137.8 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Adap_comp_sub PF00928.21 ETS62637.1 - 1.3e-22 80.5 0.0 1.7e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETS62637.1 - 3.2e-05 23.9 0.0 5e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain TT_ORF2 PF02957.15 ETS62637.1 - 0.22 12.4 1.0 0.4 11.6 0.2 1.8 1 1 1 2 2 2 0 TT viral ORF2 DUF656 PF04920.12 ETS62638.1 - 0.12 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF656) RRM_1 PF00076.22 ETS62640.1 - 1.5e-18 66.3 0.3 2.4e-09 36.9 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS62640.1 - 0.00087 18.9 0.0 0.83 9.3 0.0 2.3 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETS62640.1 - 0.0075 16.2 0.2 0.58 10.2 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4523 PF15023.6 ETS62640.1 - 0.1 12.4 0.0 0.92 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) RRM_1 PF00076.22 ETS62642.1 - 4.6e-22 77.6 0.0 6.5e-22 77.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS62642.1 - 0.016 14.8 0.0 0.023 14.3 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DDE_Tnp_1 PF01609.21 ETS62642.1 - 0.044 13.4 0.0 0.063 12.9 0.0 1.2 1 0 0 1 1 1 0 Transposase DDE domain RRM_occluded PF16842.5 ETS62642.1 - 0.094 12.6 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif DUF1302 PF06980.11 ETS62642.1 - 0.12 11.0 0.2 0.14 10.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1302) RRM_3 PF08777.11 ETS62642.1 - 0.14 12.2 0.0 0.21 11.7 0.0 1.2 1 0 0 1 1 1 0 RNA binding motif Limkain-b1 PF11608.8 ETS62642.1 - 0.14 12.2 0.2 0.37 10.9 0.1 1.7 2 0 0 2 2 2 0 Limkain b1 GRP PF07172.11 ETS62642.1 - 3.5 8.4 10.4 7.8 7.3 10.4 1.6 1 0 0 1 1 1 0 Glycine rich protein family RRM_1 PF00076.22 ETS62643.1 - 1.3e-12 47.3 0.0 2.4e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETS62643.1 - 0.0058 16.6 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif SET PF00856.28 ETS62644.1 - 7.4e-14 52.5 0.0 1.5e-13 51.5 0.0 1.6 1 0 0 1 1 1 1 SET domain zf-MYND PF01753.18 ETS62644.1 - 0.014 15.5 6.1 0.014 15.5 6.1 1.8 2 0 0 2 2 2 0 MYND finger NST1 PF13945.6 ETS62645.1 - 7.7e-51 172.9 2.2 7.7e-51 172.9 2.2 5.2 3 2 1 4 4 4 2 Salt tolerance down-regulator Mid1 PF12929.7 ETS62648.1 - 4.6e-72 243.6 2.1 6.4e-72 243.1 2.1 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 ETS62648.1 - 0.0078 16.8 4.1 0.032 14.8 0.6 2.6 2 0 0 2 2 2 1 Fz domain fn3 PF00041.21 ETS62648.1 - 0.24 11.8 2.1 0.44 10.9 0.1 2.3 2 1 0 2 2 2 0 Fibronectin type III domain ABC1 PF03109.16 ETS62649.1 - 1.3e-28 99.6 0.0 2.4e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Oxidored-like PF09791.9 ETS62649.1 - 8.9e-18 63.7 0.3 8.9e-18 63.7 0.3 2.4 2 0 0 2 2 2 1 Oxidoreductase-like protein, N-terminal CK2S PF15011.6 ETS62649.1 - 0.16 11.9 0.1 0.34 10.8 0.1 1.5 1 0 0 1 1 1 0 Casein Kinase 2 substrate Pkinase PF00069.25 ETS62649.1 - 0.21 10.9 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain DUF5522 PF17653.1 ETS62649.1 - 0.24 11.4 4.0 0.49 10.4 4.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5522) Lipase_3 PF01764.25 ETS62650.1 - 1e-14 54.6 0.0 2e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.20 ETS62650.1 - 0.0003 20.5 0.0 0.0006 19.5 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS62650.1 - 0.047 14.3 0.4 0.12 12.9 0.2 1.8 1 1 0 1 1 1 0 Alpha/beta hydrolase family LIDHydrolase PF10230.9 ETS62650.1 - 0.2 11.2 0.0 0.39 10.2 0.0 1.4 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase MFS_1 PF07690.16 ETS62651.1 - 5.8e-25 88.0 44.2 5.8e-25 88.0 44.2 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily OATP PF03137.20 ETS62651.1 - 0.00069 18.0 1.8 0.029 12.7 0.2 2.5 2 0 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Gp_dh_C PF02800.20 ETS62652.1 - 2.7e-72 241.6 0.0 3.8e-72 241.0 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ETS62652.1 - 1.5e-38 131.2 0.2 3e-38 130.2 0.2 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain TauD PF02668.16 ETS62653.1 - 1.9e-25 90.2 2.1 4.7e-25 88.9 2.1 1.6 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family RNA_pol PF00940.19 ETS62654.1 - 4.6e-175 582.4 0.0 7.1e-175 581.8 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 ETS62654.1 - 6.2e-98 328.3 3.6 6.2e-98 328.3 3.6 2.0 2 0 0 2 2 2 1 DNA-directed RNA polymerase N-terminal PPR_2 PF13041.6 ETS62654.1 - 0.00086 19.5 0.0 0.12 12.6 0.0 3.1 2 1 0 2 2 2 1 PPR repeat family SpoU_sub_bind PF08032.12 ETS62654.1 - 0.028 14.7 0.2 0.097 13.0 0.2 1.9 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding Ras PF00071.22 ETS62655.1 - 1.8e-50 170.7 0.0 2.1e-50 170.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS62655.1 - 3.7e-23 82.0 0.0 6.7e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS62655.1 - 4.3e-06 26.3 0.0 6.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS62655.1 - 0.023 14.3 0.0 0.053 13.0 0.0 1.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ETS62655.1 - 0.058 13.8 0.0 0.13 12.6 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 ETS62655.1 - 0.094 12.5 0.0 10 5.9 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 ETS62655.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PCI PF01399.27 ETS62656.1 - 2e-10 41.1 0.0 5.8e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 PCI domain Swm2 PF17083.5 ETS62656.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Nucleolar protein Swm2 Amidohydro_3 PF07969.11 ETS62657.1 - 2.5e-75 254.8 3.6 3.4e-75 254.3 3.6 1.2 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 ETS62657.1 - 4.4e-09 36.1 0.0 3.5e-08 33.1 0.0 2.3 2 1 0 2 2 2 1 Amidohydrolase family Methyltransf_25 PF13649.6 ETS62657.1 - 1e-08 35.7 0.0 2.5e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS62657.1 - 3.1e-08 33.6 0.0 7.2e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS62657.1 - 5.9e-08 33.4 0.0 1.1e-07 32.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS62657.1 - 1.2e-07 31.7 0.0 2.7e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS62657.1 - 8.3e-07 29.6 0.0 1.9e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 ETS62657.1 - 0.0002 22.3 0.0 0.00069 20.6 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS62657.1 - 0.00031 20.3 0.0 0.0006 19.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 ETS62657.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 ETS62657.1 - 0.015 14.6 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ETS62657.1 - 0.15 11.4 0.0 0.36 10.1 0.0 1.5 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF1289 PF06945.13 ETS62658.1 - 0.17 11.7 0.2 0.26 11.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) FA_desaturase PF00487.24 ETS62659.1 - 1.4e-23 84.0 26.8 3e-23 83.0 26.8 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ETS62659.1 - 2.1e-12 47.0 0.0 4.5e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CX9C PF16860.5 ETS62659.1 - 0.091 12.8 0.8 0.29 11.2 0.6 1.9 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Abhydrolase_1 PF00561.20 ETS62660.1 - 7.4e-09 35.6 0.0 2.9e-07 30.4 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS62660.1 - 0.019 14.2 0.0 6 6.1 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 WD40 PF00400.32 ETS62661.1 - 1.3e-10 41.7 1.8 0.0002 22.1 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62661.1 - 1e-09 38.6 0.0 0.014 15.7 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS62661.1 - 0.0037 16.3 0.3 0.015 14.3 0.0 2.1 3 0 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETS62661.1 - 0.0095 15.9 1.3 0.19 11.7 0.0 3.0 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETS62661.1 - 0.037 13.4 0.1 0.072 12.4 0.1 1.4 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal DUF1206 PF06724.11 ETS62661.1 - 0.31 11.2 2.6 0.27 11.3 0.5 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) MFS_1 PF07690.16 ETS62662.1 - 2.4e-19 69.5 33.2 2.4e-19 69.5 33.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 ETS62662.1 - 8.1e-15 54.9 8.1 2.5e-14 53.3 8.1 1.9 1 0 0 1 1 1 1 Ion channel regulatory protein UNC-93 TUDOR PF00567.24 ETS62663.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.4 1 0 0 1 1 1 0 Tudor domain Abhydrolase_3 PF07859.13 ETS62664.1 - 1.7e-46 158.7 0.0 2.2e-46 158.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ETS62664.1 - 2e-07 30.3 1.5 1.1e-06 27.8 1.5 1.8 1 1 0 1 1 1 1 Carboxylesterase family AXE1 PF05448.12 ETS62664.1 - 0.00078 18.2 0.0 0.015 14.0 0.0 2.0 2 0 0 2 2 2 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ETS62664.1 - 0.0012 18.4 0.3 0.061 12.8 0.3 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydro_lipase PF04083.16 ETS62664.1 - 0.0014 18.2 0.1 0.0023 17.5 0.1 1.3 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 ETS62664.1 - 0.015 14.6 0.3 0.04 13.2 0.0 1.9 3 1 0 3 3 3 0 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 ETS62664.1 - 0.078 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase DUF4499 PF14934.6 ETS62665.1 - 0.009 16.3 1.1 0.019 15.3 0.6 1.6 1 1 0 2 2 2 1 Domain of unknown function (DUF4499) DUF1929 PF09118.11 ETS62666.1 - 2.2e-15 56.7 0.2 4.6e-15 55.7 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_1 PF01344.25 ETS62666.1 - 2.2e-06 27.1 0.8 5.7e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETS62666.1 - 0.013 15.7 4.9 0.27 11.6 0.1 3.6 3 1 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETS62666.1 - 0.53 10.3 0.1 0.53 10.3 0.1 3.1 3 1 0 3 3 3 0 Galactose oxidase, central domain Sugar_tr PF00083.24 ETS62667.1 - 2e-106 356.6 24.2 2.3e-106 356.4 24.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS62667.1 - 4.7e-20 71.8 36.2 2.1e-19 69.7 7.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DHDPS PF00701.22 ETS62668.1 - 4e-31 107.8 0.0 4.9e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family rve_3 PF13683.6 ETS62668.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain Zn_clus PF00172.18 ETS62669.1 - 1.4e-09 37.9 6.3 2.3e-09 37.2 6.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS62669.1 - 0.00055 19.0 0.0 0.001 18.2 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain BioT2 PF15368.6 ETS62669.1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Spermatogenesis family BioT2 Sacchrp_dh_NADP PF03435.18 ETS62670.1 - 0.019 15.2 0.0 0.035 14.4 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 ETS62670.1 - 0.15 11.5 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Anti-TRAP PF15777.5 ETS62671.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein Tannase PF07519.11 ETS62672.1 - 1.1e-113 380.6 0.7 1.4e-113 380.3 0.7 1.0 1 0 0 1 1 1 1 Tannase and feruloyl esterase Peptidase_S9 PF00326.21 ETS62672.1 - 0.083 12.4 1.6 4.3 6.7 0.1 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Glyco_hydro_11 PF00457.17 ETS62673.1 - 1.6e-57 194.0 17.3 1.8e-57 193.8 17.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 11 Dynactin_p62 PF05502.13 ETS62675.1 - 2.9e-60 204.4 16.8 2.9e-60 204.4 16.8 3.3 2 1 0 2 2 2 1 Dynactin p62 family zf-4CXXC_R1 PF10497.9 ETS62675.1 - 1.7 8.9 11.3 0.93 9.8 8.2 2.1 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Cwf_Cwc_15 PF04889.12 ETS62675.1 - 1.8 8.2 13.9 0.083 12.6 8.2 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 ETS62675.1 - 2.7 6.1 7.9 4.2 5.5 7.9 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETS62675.1 - 5.7 6.3 15.9 8.4 5.7 9.7 2.2 2 0 0 2 2 2 0 SDA1 polyprenyl_synt PF00348.17 ETS62676.1 - 3.6e-93 311.3 0.0 4.6e-93 311.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase YtzH PF14165.6 ETS62676.1 - 0.14 12.6 0.1 0.56 10.6 0.0 2.1 1 1 1 2 2 2 0 YtzH-like protein Rsa3 PF14615.6 ETS62677.1 - 2.5e-14 52.6 0.0 4.6e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Fungal_trans PF04082.18 ETS62678.1 - 2.1e-23 82.7 0.1 4.1e-23 81.8 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ETS62678.1 - 7.5e-09 35.6 8.5 0.00024 21.4 3.9 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS62678.1 - 0.0004 21.0 6.8 0.048 14.5 3.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-BED PF02892.15 ETS62678.1 - 0.002 18.1 2.5 0.002 18.1 2.5 2.1 2 0 0 2 2 2 1 BED zinc finger zf-Di19 PF05605.12 ETS62678.1 - 0.021 15.1 0.6 0.049 13.9 0.6 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 ETS62678.1 - 0.055 13.8 2.9 2.6 8.5 1.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2HE PF16278.5 ETS62678.1 - 0.082 13.4 0.2 0.18 12.3 0.2 1.6 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_11 PF16622.5 ETS62678.1 - 0.26 11.1 2.3 0.7 9.7 2.3 1.8 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-H2C2_2 PF13465.6 ETS62678.1 - 0.52 10.8 7.6 2.3 8.8 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger double domain Epimerase PF01370.21 ETS62679.1 - 4.5e-16 59.0 0.0 5.8e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS62679.1 - 5.1e-11 42.6 0.0 7.7e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ETS62679.1 - 1.2e-06 27.7 0.0 1.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETS62679.1 - 4.5e-06 26.0 0.0 6.8e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ETS62679.1 - 0.00057 19.1 0.0 0.13 11.4 0.0 2.9 1 1 1 2 2 2 2 Male sterility protein adh_short_C2 PF13561.6 ETS62679.1 - 0.0017 17.9 0.0 0.0028 17.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 ETS62679.1 - 0.073 12.2 0.0 0.42 9.7 0.0 2.1 2 1 0 2 2 2 0 Polysaccharide biosynthesis protein MFS_1 PF07690.16 ETS62680.1 - 1e-34 120.0 28.4 1.2e-34 119.8 27.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Pkinase PF00069.25 ETS62681.1 - 4e-51 173.9 0.1 4.9e-31 108.1 0.0 3.5 4 0 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62681.1 - 1.9e-26 92.9 0.7 1.3e-21 77.0 0.0 3.4 4 0 0 4 4 4 3 Protein tyrosine kinase Kinase-like PF14531.6 ETS62681.1 - 6.9e-05 22.3 0.0 0.15 11.3 0.0 3.0 3 0 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 ETS62681.1 - 0.0013 17.6 0.0 0.0031 16.3 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETS62681.1 - 0.04 13.8 4.5 0.048 13.6 0.2 2.8 2 1 0 2 2 2 0 Phosphotransferase enzyme family Keratin PF02422.16 ETS62682.1 - 0.019 14.7 1.2 0.019 14.7 1.2 1.5 1 1 0 1 1 1 0 Keratin Cyto_heme_lyase PF01265.17 ETS62683.1 - 6.9e-75 252.3 22.1 5.4e-61 206.7 7.5 3.4 1 1 1 2 2 2 2 Cytochrome c/c1 heme lyase UbiA PF01040.18 ETS62684.1 - 4.4e-44 150.7 19.0 4.4e-44 150.7 19.0 2.6 2 1 0 2 2 2 1 UbiA prenyltransferase family MCU PF04678.13 ETS62684.1 - 1.3e-29 103.5 0.0 3.1e-29 102.3 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Brr6_like_C_C PF10104.9 ETS62686.1 - 1.3e-41 141.5 0.6 1.8e-41 141.1 0.6 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain PBP1_TM PF14812.6 ETS62686.1 - 0.0071 16.7 2.9 0.017 15.5 2.9 1.7 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Y_phosphatase2 PF03162.13 ETS62687.1 - 1.5e-24 86.4 0.0 6.8e-23 81.1 0.0 2.3 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ETS62687.1 - 0.073 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Nucleo_P87 PF07267.11 ETS62687.1 - 3.6 6.3 14.4 5.7 5.7 14.4 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF5523 PF17661.1 ETS62687.1 - 4 7.1 24.1 6.7 6.3 24.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) AIP3 PF03915.13 ETS62688.1 - 1.9e-139 465.3 2.5 3.5e-139 464.4 2.5 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 CHDCT2 PF08074.11 ETS62688.1 - 0.075 13.2 0.3 0.61 10.2 0.0 2.6 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain DUF383 PF04063.14 ETS62689.1 - 3.7e-61 206.1 0.0 1e-60 204.7 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF383) DUF384 PF04064.13 ETS62689.1 - 3.2e-16 58.9 0.6 7.7e-16 57.7 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF384) HEAT PF02985.22 ETS62689.1 - 0.014 15.6 1.0 0.2 12.0 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat Zn_clus PF00172.18 ETS62690.1 - 2e-09 37.4 10.2 4.7e-09 36.2 10.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS62690.1 - 0.00059 18.9 0.1 0.0011 18.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HMG_box PF00505.19 ETS62691.1 - 1.5e-09 38.1 4.1 2e-08 34.5 4.1 2.5 1 1 0 1 1 1 1 HMG (high mobility group) box DNA_pol_B PF00136.21 ETS62693.1 - 2.1e-149 498.1 1.0 2.8e-149 497.7 1.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ETS62693.1 - 4.9e-89 298.8 0.0 8e-89 298.1 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ETS62693.1 - 6.7e-17 61.7 8.9 1.5e-16 60.6 8.9 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 ETS62693.1 - 0.0056 15.6 0.4 0.029 13.2 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral AMP-binding PF00501.28 ETS62694.1 - 1e-84 284.6 0.0 1.3e-84 284.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS62694.1 - 6.1e-15 56.0 0.4 1.7e-14 54.5 0.4 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 ETS62694.1 - 9.2e-05 21.5 0.0 0.02 13.8 0.0 2.2 2 0 0 2 2 2 2 GH3 auxin-responsive promoter HK PF02110.15 ETS62694.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family Methyltr_RsmB-F PF01189.17 ETS62695.1 - 8.8e-74 247.5 0.0 1.2e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ETS62695.1 - 5.3e-09 36.4 0.0 1.4e-08 35.1 0.0 1.8 2 0 0 2 2 2 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 ETS62695.1 - 0.00032 20.5 0.0 0.0007 19.4 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein FtsJ PF01728.19 ETS62695.1 - 0.0035 17.5 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 FtsJ-like methyltransferase PCMT PF01135.19 ETS62695.1 - 0.0036 17.1 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ETS62695.1 - 0.0038 17.0 0.0 0.0074 16.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF2431 PF10354.9 ETS62695.1 - 0.043 14.1 0.0 0.073 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) DUF938 PF06080.12 ETS62695.1 - 0.059 13.1 0.1 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF938) Sigma70_ner PF04546.13 ETS62695.1 - 0.17 11.7 2.9 0.27 11.1 0.1 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Acyl-CoA_dh_1 PF00441.24 ETS62696.1 - 2e-31 109.2 0.3 3.3e-31 108.5 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS62696.1 - 1.1e-16 60.7 1.8 2.1e-16 59.9 0.6 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 ETS62696.1 - 3.1e-16 59.3 0.0 8.1e-16 57.9 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 ETS62696.1 - 1.1e-13 51.8 0.0 2.4e-12 47.5 0.0 3.1 3 1 1 4 4 4 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ETS62696.1 - 4.3e-08 33.5 0.5 8.6e-08 32.5 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ETS62696.1 - 0.04 13.6 0.0 0.066 12.9 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal EIF_2_alpha PF07541.12 ETS62697.1 - 5.1e-37 126.5 0.3 1.1e-36 125.4 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ETS62697.1 - 7.7e-15 55.0 1.5 1.7e-14 53.9 0.5 2.1 2 0 0 2 2 2 1 S1 RNA binding domain EXOSC1 PF10447.9 ETS62697.1 - 0.019 15.6 1.1 0.77 10.4 0.2 3.1 2 1 0 2 2 2 0 Exosome component EXOSC1/CSL4 DUF4453 PF14627.6 ETS62697.1 - 0.12 12.5 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4453) NRDE-2 PF08424.10 ETS62698.1 - 5.3e-39 134.2 0.2 1.2e-38 133.0 0.2 1.6 1 0 0 1 1 1 1 NRDE-2, necessary for RNA interference Ank_4 PF13637.6 ETS62698.1 - 0.00021 21.8 0.3 0.00085 19.8 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS62698.1 - 0.00025 21.5 0.0 0.00077 20.0 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETS62698.1 - 0.0021 18.4 0.9 2.4 9.0 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETS62698.1 - 0.0027 18.0 0.4 0.063 13.6 0.0 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETS62698.1 - 0.067 13.7 0.2 2.1 9.0 0.0 3.2 3 0 0 3 3 3 0 Ankyrin repeat F-box-like PF12937.7 ETS62698.1 - 0.072 13.0 1.6 1.1 9.3 0.1 2.7 2 0 0 2 2 2 0 F-box-like Stealth_CR2 PF11380.8 ETS62699.1 - 4.9e-10 39.6 0.7 1.3e-06 28.5 0.0 3.5 4 0 0 4 4 4 2 Stealth protein CR2, conserved region 2 Stealth_CR3 PF17102.5 ETS62699.1 - 1e-08 34.9 0.2 1e-08 34.9 0.2 2.0 2 0 0 2 2 2 1 Stealth protein CR3, conserved region 3 Stealth_CR1 PF17101.5 ETS62699.1 - 7.5e-06 25.6 0.1 2.4e-05 24.0 0.1 1.9 1 0 0 1 1 1 1 Stealth protein CR1, conserved region 1 Stealth_CR4 PF17103.5 ETS62699.1 - 0.003 17.4 0.0 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 Stealth protein CR4, conserved region 4 zf-LITAF-like PF10601.9 ETS62700.1 - 4.1 7.7 12.6 0.2 12.0 1.0 3.5 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain Carn_acyltransf PF00755.20 ETS62701.1 - 3.6e-172 574.1 0.0 4.1e-172 573.9 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase RabGAP-TBC PF00566.18 ETS62702.1 - 3.3e-52 177.3 0.0 4.8e-52 176.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain CPSF73-100_C PF11718.8 ETS62703.1 - 2.8e-54 184.0 0.4 8.1e-54 182.4 0.4 1.8 1 1 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 ETS62703.1 - 6.3e-29 100.5 0.0 2.2e-28 98.8 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.27 ETS62703.1 - 1.5e-21 77.3 0.6 4.4e-21 75.8 0.3 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ETS62703.1 - 1.3e-19 70.4 0.0 3.2e-19 69.1 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 ETS62703.1 - 1e-16 60.6 0.1 2.8e-16 59.2 0.1 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_3 PF13483.6 ETS62703.1 - 2.8e-08 33.8 0.4 9.3e-08 32.1 0.0 2.0 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ETS62703.1 - 1.6e-07 31.1 3.0 3.4e-07 30.0 1.3 2.3 2 0 0 2 2 2 1 Beta-lactamase superfamily domain MRP_L53 PF10780.9 ETS62704.1 - 9.1e-05 22.6 0.1 0.00016 21.8 0.1 1.5 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Tti2 PF10521.9 ETS62705.1 - 1.3e-18 67.6 0.0 2e-17 63.6 0.0 2.3 1 1 0 1 1 1 1 Tti2 family tRNA-synt_1d PF00750.19 ETS62706.1 - 4.7e-96 321.8 2.0 6.1e-96 321.4 2.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ETS62706.1 - 5.8e-22 78.1 0.0 1.8e-21 76.5 0.0 1.9 1 0 0 1 1 1 1 DALR anticodon binding domain POT1 PF02765.17 ETS62706.1 - 0.01 15.7 0.1 0.066 13.1 0.0 2.0 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 UxaE PF16257.5 ETS62706.1 - 0.051 12.2 0.1 0.082 11.6 0.1 1.3 1 0 0 1 1 1 0 tagaturonate epimerase UPF0242 PF06785.11 ETS62707.1 - 0.26 11.4 16.4 1.8 8.6 1.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus KASH_CCD PF14662.6 ETS62707.1 - 0.85 9.4 16.4 0.092 12.6 9.1 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH HIP1_clath_bdg PF16515.5 ETS62707.1 - 8.2 7.1 22.3 4 8.1 0.3 3.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ArabFuran-catal PF09206.11 ETS62708.1 - 2e-148 493.9 14.9 2.3e-148 493.7 14.9 1.0 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic F-box-like PF12937.7 ETS62709.1 - 0.052 13.4 0.1 0.16 11.9 0.1 1.9 1 1 0 1 1 1 0 F-box-like GCP_N_terminal PF17681.1 ETS62710.1 - 4.9e-66 223.4 0.0 7.8e-66 222.8 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ETS62710.1 - 6.8e-38 130.9 6.1 1.1e-37 130.2 6.1 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DPBB_1 PF03330.18 ETS62710.1 - 0.18 12.1 0.0 0.9 9.9 0.0 2.1 2 0 0 2 2 2 0 Lytic transglycolase GAS PF13851.6 ETS62710.1 - 9.4 5.5 9.2 0.46 9.8 2.6 2.0 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DEK_C PF08766.11 ETS62711.1 - 3.6e-12 46.0 0.1 8.3e-12 44.9 0.1 1.7 1 0 0 1 1 1 1 DEK C terminal domain Sugar_tr PF00083.24 ETS62712.1 - 3.5e-100 336.0 20.2 4.1e-100 335.8 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS62712.1 - 1.4e-20 73.6 27.2 3.4e-19 69.0 15.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FA_hydroxylase PF04116.13 ETS62713.1 - 1.3e-19 70.9 18.8 1.3e-19 70.9 18.8 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Peptidase_M16 PF00675.20 ETS62714.1 - 3.8e-22 78.9 2.1 9.5e-22 77.6 0.3 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ETS62714.1 - 3.2e-11 43.6 0.0 1.2e-10 41.7 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain Sad1_UNC PF07738.13 ETS62715.1 - 1.3e-08 34.9 0.0 9.1e-06 25.7 0.0 2.3 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal DUF445 PF04286.12 ETS62715.1 - 0.00074 19.4 4.8 0.0011 18.9 4.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF445) Nup54 PF13874.6 ETS62715.1 - 0.04 14.0 1.5 0.1 12.7 1.5 1.6 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 ARGLU PF15346.6 ETS62715.1 - 0.097 12.6 6.7 0.49 10.3 1.4 2.4 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 CENP-Q PF13094.6 ETS62715.1 - 1.1 9.5 14.5 0.18 12.0 7.9 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.12 ETS62715.1 - 1.1 9.3 4.5 2.7 8.1 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ETS62715.1 - 2.3 8.4 3.9 4.8 7.4 3.9 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HIP1_clath_bdg PF16515.5 ETS62715.1 - 2.8 8.6 7.9 1.6 9.4 1.8 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PBP1_TM PF14812.6 ETS62715.1 - 3.6 8.0 18.9 2.6 8.5 2.1 3.0 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ATP_bind_1 PF03029.17 ETS62716.1 - 7e-71 238.8 0.3 4e-64 216.7 0.0 2.8 3 0 0 3 3 3 2 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ETS62716.1 - 9.7e-06 25.3 0.1 9.6e-05 22.0 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ETS62716.1 - 0.0034 17.8 0.0 0.01 16.2 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETS62716.1 - 0.0036 17.6 0.0 0.011 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETS62716.1 - 0.0036 17.2 0.0 0.76 9.7 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase MeaB PF03308.16 ETS62716.1 - 0.0048 15.9 0.0 0.19 10.7 0.0 2.3 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FeoB_N PF02421.18 ETS62716.1 - 0.0069 15.9 0.0 0.017 14.7 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ETS62716.1 - 0.0093 16.0 0.0 0.071 13.2 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase NACHT PF05729.12 ETS62716.1 - 0.01 15.8 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 ETS62716.1 - 0.018 15.6 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 ETS62716.1 - 0.057 13.5 0.3 0.5 10.4 0.0 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain G-alpha PF00503.20 ETS62716.1 - 0.098 11.8 0.0 3 6.9 0.0 2.2 2 0 0 2 2 2 0 G-protein alpha subunit AAA_33 PF13671.6 ETS62716.1 - 0.11 12.7 0.2 0.11 12.7 0.2 2.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETS62716.1 - 0.12 12.7 0.0 0.63 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA helicase SRP54 PF00448.22 ETS62716.1 - 0.14 11.8 0.0 1.3 8.6 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PPV_E1_C PF00519.17 ETS62716.1 - 0.16 10.8 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase NB-ARC PF00931.22 ETS62716.1 - 0.2 10.8 0.0 0.37 10.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 ETS62716.1 - 0.24 11.3 0.0 17 5.3 0.0 2.2 2 0 0 2 2 2 0 NTPase Zn_clus PF00172.18 ETS62717.1 - 8.2e-07 29.0 9.7 1.5e-06 28.2 9.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UMP1 PF05348.11 ETS62718.1 - 2.4e-35 121.3 0.2 3e-35 121.0 0.2 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 rRNA_proc-arch PF13234.6 ETS62719.1 - 6.5e-88 295.2 0.0 1e-87 294.5 0.0 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 ETS62719.1 - 7.1e-54 181.9 1.8 2e-53 180.4 1.8 1.9 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 ETS62719.1 - 9.8e-20 71.0 0.0 3.1e-18 66.2 0.0 3.1 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS62719.1 - 1.1e-06 29.0 0.0 5.6e-06 26.7 0.0 2.1 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS62719.1 - 0.00041 20.4 0.0 0.00088 19.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CENP-F_leu_zip PF10473.9 ETS62719.1 - 0.093 12.7 4.8 0.058 13.4 0.4 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 5_nucleotid_C PF02872.18 ETS62720.1 - 6.8e-29 101.1 0.0 3.2e-22 79.4 0.0 2.5 2 0 0 2 2 2 2 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ETS62720.1 - 2.6e-07 31.4 0.1 6.1e-07 30.1 0.1 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Syntaxin-6_N PF09177.11 ETS62721.1 - 2.1e-20 73.1 0.6 6.5e-19 68.3 0.1 2.2 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Use1 PF09753.9 ETS62721.1 - 3.5e-05 23.6 0.0 5.6e-05 23.0 0.0 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 SNARE PF05739.19 ETS62721.1 - 4.8e-05 23.3 8.0 0.00021 21.2 3.5 3.0 2 1 0 2 2 2 1 SNARE domain AIP3 PF03915.13 ETS62721.1 - 0.018 14.2 1.2 0.036 13.2 0.1 1.9 1 1 1 2 2 2 0 Actin interacting protein 3 Calpain_inhib PF00748.19 ETS62721.1 - 0.029 14.9 0.4 0.054 14.0 0.4 1.4 1 0 0 1 1 1 0 Calpain inhibitor Spc7 PF08317.11 ETS62721.1 - 0.044 12.7 1.1 0.92 8.3 0.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETS62721.1 - 0.07 13.2 2.3 7.8 6.6 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) WXG100 PF06013.12 ETS62721.1 - 0.14 12.4 3.2 2.7 8.3 0.3 3.5 3 1 1 4 4 4 0 Proteins of 100 residues with WXG FlaC_arch PF05377.11 ETS62721.1 - 0.17 12.3 3.9 11 6.5 0.1 3.6 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF4618 PF15397.6 ETS62721.1 - 0.35 10.3 2.1 11 5.4 0.3 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4618) SPX PF03105.19 ETS62721.1 - 0.57 10.0 3.4 1.3 8.8 3.4 1.5 1 1 0 1 1 1 0 SPX domain V-SNARE PF05008.15 ETS62721.1 - 0.86 10.0 5.2 6.8 7.1 0.1 3.5 3 2 1 4 4 4 0 Vesicle transport v-SNARE protein N-terminus Wtap PF17098.5 ETS62721.1 - 2.1 8.3 5.1 9.3 6.2 0.0 3.2 4 0 0 4 4 4 0 WTAP/Mum2p family PPTA PF01239.22 ETS62723.1 - 4.5e-30 102.5 26.3 3.2e-08 33.0 0.8 6.0 7 0 0 7 7 7 5 Protein prenyltransferase alpha subunit repeat TPR_17 PF13431.6 ETS62723.1 - 0.00023 21.3 0.2 0.14 12.6 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat HisKA PF00512.25 ETS62723.1 - 0.17 12.0 0.1 0.65 10.1 0.1 2.1 1 1 0 1 1 1 0 His Kinase A (phospho-acceptor) domain BolA PF01722.18 ETS62724.1 - 1.7e-26 92.2 0.2 3.9e-26 91.1 0.2 1.6 1 0 0 1 1 1 1 BolA-like protein Ribosomal_L9_N PF01281.19 ETS62724.1 - 1.7e-09 37.1 0.0 3.8e-09 36.0 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain polyprenyl_synt PF00348.17 ETS62725.1 - 1e-61 208.2 0.0 8.6e-55 185.6 0.0 2.6 2 1 0 2 2 2 2 Polyprenyl synthetase rhaM PF05336.13 ETS62726.1 - 1.1e-19 70.5 0.0 1.5e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 L-rhamnose mutarotase Pkinase PF00069.25 ETS62728.1 - 1.9e-58 198.0 0.0 8.5e-39 133.5 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62728.1 - 1.2e-25 90.3 0.0 5.2e-20 71.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 ETS62728.1 - 1.2e-09 38.3 0.0 2.5e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 ETS62728.1 - 1.1e-07 31.5 1.7 2.1e-05 24.0 0.1 2.5 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 ETS62728.1 - 0.0022 17.9 2.5 0.0045 17.0 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 ETS62728.1 - 0.018 14.4 0.0 0.042 13.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ETS62728.1 - 0.13 11.3 0.1 0.21 10.6 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 FTA2 PF13095.6 ETS62728.1 - 0.15 11.6 0.0 22 4.6 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ETS62728.1 - 0.26 10.2 0.0 0.43 9.5 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain TMEM52 PF14979.6 ETS62728.1 - 7.7 6.4 7.4 28 4.6 7.4 2.0 1 0 0 1 1 1 0 Transmembrane 52 Gly_transf_sug PF04488.15 ETS62729.1 - 2.1e-21 76.4 0.0 4e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Mito_carr PF00153.27 ETS62730.1 - 2.3e-80 264.6 0.1 7.1e-27 93.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ETS62730.1 - 0.05 12.7 0.4 1.1 8.3 0.0 3.0 3 1 1 4 4 4 0 Gammaproteobacterial serine protease PrcB_C PF14343.6 ETS62730.1 - 0.16 12.1 0.2 62 3.8 0.0 3.2 3 0 0 3 3 3 0 PrcB C-terminal Amidase PF01425.21 ETS62731.1 - 6e-98 328.7 0.0 1e-97 327.9 0.0 1.4 1 0 0 1 1 1 1 Amidase ERG4_ERG24 PF01222.17 ETS62732.1 - 7.2e-125 417.1 20.7 8.4e-125 416.9 20.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF4112 PF13430.6 ETS62732.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4112) Ribosomal_L29e PF01779.17 ETS62734.1 - 1.3e-20 73.4 7.1 2e-20 72.8 7.1 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family Glyco_hydro_125 PF06824.11 ETS62735.1 - 3.3e-144 480.8 0.0 4.1e-144 480.5 0.0 1.1 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) PHD PF00628.29 ETS62736.1 - 7.8e-12 44.9 16.5 3.6e-07 30.0 2.8 3.8 4 0 0 4 4 4 2 PHD-finger PHF12_MRG_bd PF16737.5 ETS62736.1 - 0.028 14.1 0.1 0.077 12.7 0.1 1.8 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain zf-PHD-like PF15446.6 ETS62736.1 - 2.6 7.6 5.2 6.2 6.4 2.0 2.5 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-HC5HC2H PF13771.6 ETS62736.1 - 2.9 8.2 4.4 0.84 9.9 0.6 1.9 2 0 0 2 2 2 0 PHD-like zinc-binding domain Vps51 PF08700.11 ETS62737.1 - 7.4e-12 45.2 0.0 3e-11 43.2 0.0 2.2 1 0 0 1 1 1 1 Vps51/Vps67 HofP PF10748.9 ETS62737.1 - 0.083 12.5 0.0 2.1 7.9 0.0 2.6 1 1 1 2 2 2 0 DNA utilization proteins HofP ApoLp-III PF07464.11 ETS62737.1 - 0.093 12.8 2.3 4.3 7.4 0.0 3.2 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Pro_isomerase PF00160.21 ETS62738.1 - 5e-53 179.6 0.0 5.6e-53 179.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Histone_H2A_C PF16211.5 ETS62739.1 - 1.9e-18 65.9 1.1 3.6e-18 65.0 1.1 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 ETS62739.1 - 5.8e-18 65.5 0.0 7.4e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ETS62739.1 - 9e-06 25.9 0.0 1.3e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ETS62740.1 - 7.4e-23 81.3 1.7 9e-23 81.1 1.7 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ETS62740.1 - 2.9e-06 27.5 1.7 3e-06 27.4 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ETS62740.1 - 0.00039 20.9 0.0 0.00064 20.2 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A RP-C PF03428.13 ETS62740.1 - 0.033 13.8 0.3 0.16 11.7 0.3 1.8 1 1 0 1 1 1 0 Replication protein C N-terminal domain CENP-W PF15510.6 ETS62740.1 - 0.036 14.3 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 ETS62740.1 - 0.057 13.5 0.1 0.068 13.2 0.1 1.1 1 0 0 1 1 1 0 YscO-like protein DUF1018 PF06252.12 ETS62740.1 - 0.064 14.3 0.5 0.1 13.6 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) Bt_P21 PF05560.11 ETS62740.1 - 0.084 12.5 0.1 0.099 12.2 0.1 1.1 1 0 0 1 1 1 0 Bacillus thuringiensis P21 molecular chaperone protein Snf7 PF03357.21 ETS62741.1 - 2.9e-30 105.1 18.0 2.9e-30 105.1 18.0 1.4 2 0 0 2 2 2 1 Snf7 SMODS PF18144.1 ETS62741.1 - 0.0059 16.8 1.4 2.2 8.4 0.3 2.2 1 1 1 2 2 2 2 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain APG6_N PF17675.1 ETS62741.1 - 0.027 15.0 4.0 0.027 15.0 4.0 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region Eno-Rase_FAD_bd PF07055.12 ETS62741.1 - 0.082 13.3 0.8 0.3 11.5 0.1 2.2 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain RBFA PF02033.18 ETS62741.1 - 3.1 8.3 7.3 4.4 7.8 5.0 2.0 1 1 1 2 2 2 0 Ribosome-binding factor A MIP PF00230.20 ETS62744.1 - 4.8e-48 163.8 8.0 6e-48 163.5 8.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein PPI_Ypi1 PF07491.11 ETS62745.1 - 4e-23 81.0 9.4 4e-23 81.0 9.4 3.2 3 1 0 3 3 3 1 Protein phosphatase inhibitor CDC45 PF02724.14 ETS62745.1 - 0.022 13.1 9.2 0.024 13.0 9.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 ETS62746.1 - 1.1e-25 90.5 0.0 2.1e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62746.1 - 8.8e-13 48.1 0.0 1.1e-11 44.5 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase zf-RING_2 PF13639.6 ETS62746.1 - 0.00021 21.5 5.0 0.00021 21.5 5.0 2.5 3 0 0 3 3 3 1 Ring finger domain SWIM PF04434.17 ETS62746.1 - 0.00049 19.7 0.4 0.0009 18.8 0.4 1.4 1 0 0 1 1 1 1 SWIM zinc finger zf-ANAPC11 PF12861.7 ETS62746.1 - 0.043 13.9 1.4 0.093 12.8 1.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 ETS62746.1 - 0.096 12.9 7.1 0.017 15.3 3.2 1.8 2 0 0 2 2 2 0 FANCL C-terminal domain RINGv PF12906.7 ETS62746.1 - 0.94 9.7 4.6 2.2 8.5 4.6 1.7 1 0 0 1 1 1 0 RING-variant domain zf-RING_5 PF14634.6 ETS62746.1 - 3 7.9 8.2 0.33 11.0 3.0 2.2 3 0 0 3 3 3 0 zinc-RING finger domain DUF4407 PF14362.6 ETS62747.1 - 0.0025 17.2 10.0 0.0042 16.5 10.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Endonuc_Holl PF10107.9 ETS62747.1 - 0.22 11.3 1.0 1.1 9.1 0.2 2.2 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase Laminin_II PF06009.12 ETS62747.1 - 0.24 11.4 4.6 0.77 9.8 1.6 2.9 3 0 0 3 3 3 0 Laminin Domain II DUF4200 PF13863.6 ETS62747.1 - 0.54 10.7 9.5 0.36 11.3 4.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Fez1 PF06818.15 ETS62747.1 - 0.87 10.0 5.9 1.6 9.2 5.0 1.8 1 1 0 1 1 1 0 Fez1 TPR_MLP1_2 PF07926.12 ETS62747.1 - 1.8 8.6 9.3 0.34 11.0 4.6 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein PRKG1_interact PF15898.5 ETS62747.1 - 2.6 9.0 8.0 0.73 10.8 2.3 2.7 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain zf-C4H2 PF10146.9 ETS62747.1 - 6.6 7.0 6.4 14 5.9 3.3 2.4 2 1 0 2 2 2 0 Zinc finger-containing protein ERM PF00769.19 ETS62747.1 - 6.6 6.5 12.4 19 5.0 12.5 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Uso1_p115_C PF04871.13 ETS62747.1 - 7.2 7.0 11.8 0.39 11.1 5.2 2.2 2 1 0 2 2 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-H PF05837.12 ETS62747.1 - 9 6.8 9.0 0.88 10.0 2.4 2.5 3 0 0 3 3 2 0 Centromere protein H (CENP-H) Seryl_tRNA_N PF02403.22 ETS62747.1 - 9.2 6.6 8.3 5.1 7.4 4.9 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Glyco_transf_24 PF18404.1 ETS62749.1 - 6.4e-144 478.3 1.7 9.9e-144 477.6 1.7 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 ETS62749.1 - 1.6e-57 195.4 0.0 3.3e-53 181.2 0.0 2.7 2 0 0 2 2 2 2 Thioredoxin-like domain UDP-g_GGTase PF06427.11 ETS62749.1 - 7.4e-35 119.4 0.0 1.9e-34 118.1 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 ETS62749.1 - 9.6e-32 109.7 0.2 3.1e-31 108.1 0.2 1.8 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 ETS62749.1 - 1.2e-30 106.8 1.5 2.8e-30 105.6 0.2 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 ETS62749.1 - 6.2e-15 55.7 2.9 6.2e-14 52.4 0.1 3.5 4 0 0 4 4 4 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 ETS62749.1 - 9e-07 28.7 0.0 1.8e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 8 DPBB_1 PF03330.18 ETS62751.1 - 3.5e-08 33.6 0.1 9.9e-08 32.2 0.1 1.9 1 0 0 1 1 1 1 Lytic transglycolase Pkinase PF00069.25 ETS62752.1 - 1.5e-64 218.0 0.0 2.3e-64 217.3 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62752.1 - 1.1e-35 123.2 0.0 5.8e-34 117.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS62752.1 - 0.0095 14.7 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ETS62752.1 - 0.011 15.4 0.2 0.11 12.0 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Kinase-like PF14531.6 ETS62752.1 - 0.012 14.9 0.0 0.1 11.9 0.0 2.2 2 1 0 2 2 2 0 Kinase-like Seadorna_VP7 PF07387.11 ETS62752.1 - 0.015 14.4 0.1 0.046 12.8 0.1 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 APH PF01636.23 ETS62752.1 - 0.04 13.8 0.0 0.26 11.2 0.1 2.1 3 0 0 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETS62752.1 - 0.068 12.1 0.3 0.22 10.4 0.1 1.7 2 0 0 2 2 2 0 Haspin like kinase domain GST_N_2 PF13409.6 ETS62753.1 - 2.6e-20 72.5 0.0 4.7e-20 71.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETS62753.1 - 5.7e-12 45.5 0.0 1.2e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETS62753.1 - 0.00071 19.7 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ETS62753.1 - 0.01 16.2 0.1 0.056 13.9 0.1 2.1 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Adeno_E4 PF05385.11 ETS62753.1 - 0.025 14.7 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Mastadenovirus early E4 13 kDa protein GST_C_3 PF14497.6 ETS62753.1 - 0.036 14.2 0.0 0.066 13.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain RasGEF PF00617.19 ETS62754.1 - 2.5e-51 174.4 0.0 4.8e-51 173.5 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETS62754.1 - 5.2e-24 84.5 0.0 1.2e-23 83.3 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_2 PF07653.17 ETS62754.1 - 2.8e-14 52.5 0.0 5.7e-14 51.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ETS62754.1 - 1e-13 50.9 0.1 2.2e-13 49.8 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ETS62754.1 - 1.5e-12 46.9 0.0 2.8e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain 2-oxoacid_dh PF00198.23 ETS62755.1 - 3.3e-78 262.3 0.1 4.6e-78 261.9 0.1 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ETS62755.1 - 2.9e-19 68.6 2.1 5.3e-19 67.8 2.1 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 ETS62755.1 - 2e-05 25.2 0.3 0.22 12.3 0.0 2.4 1 1 1 2 2 2 2 HlyD family secretion protein Biotin_lipoyl_2 PF13533.6 ETS62755.1 - 2.4e-05 24.0 0.6 0.012 15.5 0.0 2.7 2 1 1 3 3 3 2 Biotin-lipoyl like GCV_H PF01597.19 ETS62755.1 - 0.0014 18.5 0.9 0.0029 17.5 0.9 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein PI3K_1B_p101 PF10486.9 ETS62755.1 - 0.03 12.1 10.1 0.039 11.8 10.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RebB PF11747.8 ETS62755.1 - 0.058 13.5 0.8 0.15 12.2 0.8 1.6 1 0 0 1 1 1 0 Killing trait FAM76 PF16046.5 ETS62755.1 - 0.2 10.9 14.5 0.48 9.7 10.3 2.1 2 0 0 2 2 2 0 FAM76 protein Presenilin PF01080.17 ETS62755.1 - 0.26 10.0 11.9 0.44 9.3 11.9 1.3 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 ETS62755.1 - 0.31 9.8 17.6 0.52 9.1 17.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 ETS62755.1 - 0.51 9.9 10.5 0.77 9.3 10.5 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist TAF4 PF05236.14 ETS62755.1 - 1.2 8.8 16.4 2 8.1 15.7 1.6 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Roughex PF06020.11 ETS62755.1 - 1.5 7.9 9.7 2.3 7.3 9.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Macoilin PF09726.9 ETS62755.1 - 2.2 6.8 13.8 2.8 6.4 13.8 1.2 1 0 0 1 1 1 0 Macoilin family Amidohydro_2 PF04909.14 ETS62758.1 - 1.8e-07 31.3 0.0 2.8e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 ETS62758.1 - 2.1e-06 27.3 0.0 4e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Amidohydrolase family FUN14 PF04930.15 ETS62759.1 - 6.8e-20 71.3 0.4 1.5e-19 70.2 0.4 1.6 1 0 0 1 1 1 1 FUN14 family LSM PF01423.22 ETS62761.1 - 7e-17 60.9 0.0 8.4e-17 60.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ETS62761.1 - 0.056 13.1 0.0 0.074 12.7 0.0 1.2 1 0 0 1 1 1 0 Hfq protein DUF150_C PF17384.2 ETS62761.1 - 0.073 13.2 0.1 0.12 12.5 0.1 1.4 1 0 0 1 1 1 0 RimP C-terminal SH3 domain PRELI PF04707.14 ETS62762.1 - 2.9e-14 53.2 2.5 0.00054 19.8 0.0 4.2 4 0 0 4 4 4 4 PRELI-like family Bromodomain PF00439.25 ETS62764.1 - 1.6e-19 69.8 0.0 2.7e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 Bromodomain MFS_1 PF07690.16 ETS62765.1 - 6.6e-24 84.5 12.7 2.7e-23 82.5 12.2 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily TFIID_30kDa PF03540.13 ETS62766.1 - 2e-24 85.2 0.0 4.1e-24 84.3 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit CBS PF00571.28 ETS62766.1 - 2.4e-07 31.1 0.0 0.00021 21.7 0.0 2.5 2 0 0 2 2 2 2 CBS domain Ribosomal_60s PF00428.19 ETS62766.1 - 0.0075 16.8 17.7 0.098 13.3 0.0 4.4 3 1 0 3 3 3 2 60s Acidic ribosomal protein FoP_duplication PF13865.6 ETS62766.1 - 0.025 15.1 2.0 0.079 13.5 2.0 1.8 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 RTBV_P12 PF06361.11 ETS62766.1 - 4.8 7.6 8.0 16 5.9 0.0 3.2 3 0 0 3 3 3 0 Rice tungro bacilliform virus P12 protein LMBR1 PF04791.16 ETS62767.1 - 0.87 8.4 5.4 0.14 11.0 0.8 1.9 2 1 0 2 2 2 0 LMBR1-like membrane protein EMP70 PF02990.16 ETS62767.1 - 1.4 7.5 5.0 0.17 10.5 0.6 1.7 2 0 0 2 2 2 0 Endomembrane protein 70 tRNA-synt_2d PF01409.20 ETS62768.1 - 1.9e-86 289.6 0.0 2.5e-86 289.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 ETS62768.1 - 1.8e-09 37.7 0.2 9.1e-09 35.5 0.0 2.2 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 ETS62768.1 - 1e-07 31.6 0.0 0.0002 20.9 0.0 2.2 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 ETS62768.1 - 4.1e-05 22.8 0.2 0.00086 18.5 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 ETS62768.1 - 0.069 13.1 0.5 0.2 11.7 0.5 1.8 1 0 0 1 1 1 0 PheRS DNA binding domain 2 tRNA-synt_2b PF00587.25 ETS62768.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) IBN_N PF03810.19 ETS62769.1 - 1.7e-09 37.5 1.0 1.3e-07 31.4 0.3 3.2 2 1 0 2 2 2 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 ETS62769.1 - 0.074 13.4 13.5 0.025 15.0 1.7 5.1 4 0 0 4 4 4 0 HEAT repeats Xpo1 PF08389.12 ETS62769.1 - 0.11 12.5 0.0 0.48 10.5 0.0 2.2 1 0 0 1 1 1 0 Exportin 1-like protein HEAT PF02985.22 ETS62769.1 - 0.16 12.3 2.2 0.57 10.6 0.3 3.2 2 0 0 2 2 2 0 HEAT repeat G-patch PF01585.23 ETS62770.1 - 2.9e-12 46.3 1.8 2.7e-08 33.6 1.0 2.7 2 0 0 2 2 2 2 G-patch domain G-patch_2 PF12656.7 ETS62770.1 - 0.00023 21.2 0.3 0.066 13.3 0.1 2.7 2 0 0 2 2 2 2 G-patch domain Acetyltransf_1 PF00583.25 ETS62771.1 - 2.6e-13 50.2 0.0 3.8e-13 49.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS62771.1 - 2.5e-05 24.6 0.0 7.2e-05 23.1 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS62771.1 - 0.0011 18.9 0.0 0.011 15.7 0.0 2.0 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 ETS62771.1 - 0.0026 17.7 0.0 0.0037 17.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Alpha_E3_glycop PF01563.16 ETS62771.1 - 0.042 13.9 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 Alphavirus E3 glycoprotein Acetyltransf_CG PF14542.6 ETS62771.1 - 0.12 12.5 0.0 0.95 9.6 0.0 2.1 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase ATPase PF06745.13 ETS62771.1 - 0.16 11.3 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 KaiC Med20 PF08612.11 ETS62772.1 - 0.016 14.6 0.0 3.5 6.9 0.0 2.8 2 1 0 2 2 2 0 TATA-binding related factor (TRF) of subunit 20 of Mediator complex CytoC_RC PF02276.18 ETS62772.1 - 0.055 12.8 0.1 0.11 11.8 0.1 1.5 1 0 0 1 1 1 0 Photosynthetic reaction centre cytochrome C subunit Macoilin PF09726.9 ETS62772.1 - 1.9 7.0 5.6 2.9 6.3 5.6 1.2 1 0 0 1 1 1 0 Macoilin family DUF410 PF04190.13 ETS62773.1 - 7.9e-64 215.9 0.0 9.2e-64 215.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) TetR_C_33 PF13305.6 ETS62773.1 - 1.2 9.9 5.9 5.6 7.8 0.1 3.0 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain PROCN PF08083.11 ETS62774.1 - 4.4e-218 723.9 4.5 6.9e-218 723.2 4.5 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 ETS62774.1 - 2e-120 400.6 0.4 3.6e-120 399.8 0.4 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 ETS62774.1 - 8.8e-84 279.3 0.5 2.8e-83 277.6 0.5 1.9 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 ETS62774.1 - 1.9e-82 274.6 3.8 4.4e-82 273.5 3.8 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 ETS62774.1 - 2.2e-63 212.3 0.0 4.7e-63 211.2 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 ETS62774.1 - 1.4e-46 156.7 0.5 3.4e-46 155.5 0.5 1.7 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 ETS62774.1 - 2e-39 134.3 0.0 4e-39 133.3 0.0 1.5 1 0 0 1 1 1 1 PROCT (NUC072) domain JAB PF01398.21 ETS62774.1 - 0.0012 18.8 0.0 0.0032 17.4 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease ANAPC_CDC26 PF10471.9 ETS62776.1 - 1.5e-06 28.9 3.1 7.1e-06 26.8 3.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Pyr_redox_3 PF13738.6 ETS62777.1 - 1.8e-14 53.7 0.1 2.1e-12 46.9 0.0 2.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ETS62777.1 - 3.3e-13 48.9 0.0 3.8e-07 28.9 0.0 3.8 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETS62777.1 - 1.2e-09 37.8 0.0 1e-06 28.2 0.0 2.3 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS62777.1 - 6.7e-07 29.4 0.1 4.2e-05 23.6 0.0 2.7 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 ETS62777.1 - 9.4e-07 28.3 0.3 0.00023 20.4 0.0 3.1 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 ETS62777.1 - 6e-05 22.8 0.5 0.0093 15.6 0.1 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS62777.1 - 0.0038 17.4 0.1 0.0099 16.1 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_7 PF13241.6 ETS62777.1 - 0.067 13.6 0.0 22 5.6 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding JAB PF01398.21 ETS62778.1 - 1e-31 109.4 0.0 1.7e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ETS62778.1 - 3.1e-14 53.3 1.6 3.9e-14 53.0 0.5 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 ETS62778.1 - 1.2e-05 25.1 0.0 2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 ETS62778.1 - 0.021 15.0 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) Arf PF00025.21 ETS62779.1 - 8.9e-36 123.0 0.0 4.3e-25 88.2 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETS62779.1 - 4.2e-14 52.8 0.0 7.8e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETS62779.1 - 2.7e-13 49.8 0.0 2.6e-11 43.4 0.0 2.1 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 ETS62779.1 - 4.2e-08 32.8 0.0 9e-08 31.8 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETS62779.1 - 2.5e-06 27.0 0.0 2.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS62779.1 - 5.3e-06 26.5 0.0 9.4e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ETS62779.1 - 2.5e-05 23.6 0.3 7e-05 22.2 0.1 1.7 1 1 1 2 2 2 1 G-protein alpha subunit Dynamin_N PF00350.23 ETS62779.1 - 0.0027 17.8 0.0 0.25 11.4 0.2 2.2 1 1 1 2 2 2 1 Dynamin family AAA_18 PF13238.6 ETS62779.1 - 0.074 13.6 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Vps52 PF04129.12 ETS62780.1 - 1.8e-33 116.1 0.0 3e-22 79.1 0.0 3.0 3 0 0 3 3 3 3 Vps52 / Sac2 family FTA4 PF13093.6 ETS62780.1 - 0.003 17.5 5.2 0.16 11.9 0.2 2.4 2 0 0 2 2 2 2 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Sec3_C PF09763.9 ETS62780.1 - 0.018 13.4 0.0 0.44 8.9 0.0 2.0 2 0 0 2 2 2 0 Exocyst complex component Sec3 RIC1 PF07064.13 ETS62781.1 - 7.8e-104 346.6 0.0 1.4e-103 345.7 0.0 1.4 1 1 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 ETS62781.1 - 0.0001 22.5 0.2 0.45 10.8 0.0 4.7 5 2 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQ-loop PF04193.14 ETS62782.1 - 5.2e-36 122.2 5.0 5.2e-19 67.8 0.3 2.5 2 0 0 2 2 2 2 PQ loop repeat Sre PF03125.18 ETS62782.1 - 0.18 10.9 0.7 0.27 10.4 0.7 1.2 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor SPX PF03105.19 ETS62783.1 - 0.047 13.6 0.3 0.062 13.2 0.3 1.1 1 0 0 1 1 1 0 SPX domain ECH_1 PF00378.20 ETS62784.1 - 1.4e-18 67.2 0.6 2.6e-18 66.3 0.6 1.4 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Formyl_trans_C PF02911.18 ETS62784.1 - 3e-05 24.2 0.0 7.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain MFS_1 PF07690.16 ETS62786.1 - 6.3e-36 124.0 24.8 6.3e-36 124.0 24.8 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF1294 PF06961.13 ETS62786.1 - 0.077 13.2 0.0 0.23 11.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Wzz PF02706.15 ETS62786.1 - 0.31 11.4 4.6 11 6.4 0.0 3.8 2 1 0 3 3 3 0 Chain length determinant protein CIAPIN1 PF05093.13 ETS62787.1 - 1.6e-32 112.0 4.5 3.2e-32 111.0 4.5 1.5 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 ETS62787.1 - 2.2e-07 31.2 0.0 3.6e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus WBS_methylT PF12589.8 ETS62788.1 - 2.4e-22 79.5 9.0 4.2e-22 78.7 9.0 1.4 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 ETS62788.1 - 5.5e-11 43.0 0.0 1e-10 42.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS62788.1 - 2.2e-09 37.9 0.0 4.5e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS62788.1 - 1.4e-06 28.2 0.0 2.2e-06 27.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS62788.1 - 2.4e-06 28.2 0.0 6.6e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS62788.1 - 0.00018 21.4 0.0 0.00039 20.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ETS62788.1 - 0.0034 17.7 0.0 0.046 14.1 0.0 2.3 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase N6_N4_Mtase PF01555.18 ETS62788.1 - 0.047 13.4 0.0 0.14 11.8 0.0 1.7 2 0 0 2 2 2 0 DNA methylase adh_short PF00106.25 ETS62790.1 - 4.9e-08 32.7 0.4 0.037 13.5 0.0 3.5 2 1 0 2 2 2 2 short chain dehydrogenase XRCC4 PF06632.12 ETS62791.1 - 0.23 10.3 0.5 0.35 9.7 0.5 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Peptidase_S9 PF00326.21 ETS62792.1 - 2e-40 138.5 0.2 6e-28 97.8 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family PIG-H PF10181.9 ETS62792.1 - 3.1e-13 49.4 0.0 5.8e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component DLH PF01738.18 ETS62792.1 - 3.6e-08 33.2 0.2 9.3e-08 31.9 0.2 1.7 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ETS62792.1 - 2e-05 24.7 0.0 3.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Hydrolase_4 PF12146.8 ETS62792.1 - 2.5e-05 23.7 2.4 0.00018 20.8 0.0 2.8 4 0 0 4 4 4 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ETS62792.1 - 0.00091 19.3 0.0 0.0024 17.9 0.0 1.7 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 ETS62792.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ETS62792.1 - 0.034 13.8 2.7 0.2 11.3 0.0 2.7 2 1 1 3 3 3 0 alpha/beta hydrolase fold eRF1_1 PF03463.15 ETS62793.1 - 6.8e-51 171.6 0.0 9.4e-51 171.2 0.0 1.2 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 ETS62793.1 - 3.1e-23 82.4 0.0 6.1e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_2 PF03464.15 ETS62793.1 - 5.8e-21 75.2 0.0 9.3e-21 74.5 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 L51_S25_CI-B8 PF05047.16 ETS62794.1 - 3.8e-14 52.3 0.0 4.9e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain RAI16-like PF10257.9 ETS62795.1 - 3.7e-52 177.4 0.0 5.9e-52 176.7 0.0 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Pex24p PF06398.11 ETS62796.1 - 3.4e-25 88.8 15.3 8.6e-25 87.5 6.9 3.2 2 2 0 2 2 2 2 Integral peroxisomal membrane peroxin Gly_acyl_tr_C PF08444.10 ETS62796.1 - 0.15 12.3 0.0 0.32 11.3 0.0 1.5 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region PIG-S PF10510.9 ETS62797.1 - 5.3e-120 401.7 1.9 6.9e-120 401.3 1.9 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Aldo_ket_red PF00248.21 ETS62798.1 - 2e-42 145.4 0.0 1.1e-40 139.7 0.0 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family zf-CCHC PF00098.23 ETS62799.1 - 0.0001 22.2 0.4 0.0003 20.7 0.4 1.8 1 0 0 1 1 1 1 Zinc knuckle Zn_clus PF00172.18 ETS62800.1 - 0.0019 18.3 7.5 0.0019 18.3 7.5 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sec39 PF08314.11 ETS62801.1 - 1.3e-26 93.3 0.0 2.3e-26 92.5 0.0 1.4 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Med21 PF11221.8 ETS62802.1 - 4.5e-23 82.1 6.3 5.8e-23 81.8 6.3 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Spc7 PF08317.11 ETS62802.1 - 0.012 14.5 2.3 0.016 14.1 2.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2730 PF10805.8 ETS62802.1 - 0.024 14.7 1.2 0.059 13.5 1.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) Syntaxin_2 PF14523.6 ETS62802.1 - 0.027 14.8 0.7 0.046 14.1 0.7 1.4 1 0 0 1 1 1 0 Syntaxin-like protein HisKA_3 PF07730.13 ETS62802.1 - 0.037 14.5 2.6 4.4 7.9 1.6 2.3 1 1 1 2 2 2 0 Histidine kinase DUF948 PF06103.11 ETS62802.1 - 0.077 13.3 1.7 0.46 10.8 1.1 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Ebp2 PF05890.12 ETS62802.1 - 0.11 12.1 0.4 0.13 11.8 0.4 1.1 1 0 0 1 1 1 0 Eukaryotic rRNA processing protein EBP2 ICMT PF04140.14 ETS62803.1 - 9.6e-25 86.8 1.4 1.1e-24 86.6 0.1 1.8 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETS62803.1 - 1.1e-10 41.9 0.5 1.1e-10 41.9 0.5 2.1 3 0 0 3 3 3 1 Phospholipid methyltransferase NnrU PF07298.11 ETS62803.1 - 0.0002 21.0 3.6 0.0002 21.0 3.6 1.6 2 0 0 2 2 2 1 NnrU protein DUF1295 PF06966.12 ETS62803.1 - 0.00083 18.9 1.4 0.0014 18.2 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF423 PF04241.15 ETS62803.1 - 0.015 15.5 0.6 0.073 13.3 0.5 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF423) Ribosomal_S18 PF01084.20 ETS62804.1 - 9.3e-20 70.6 0.0 2.2e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S18 Acetyltransf_2 PF00797.17 ETS62805.1 - 8.9e-23 81.3 0.3 1.5e-21 77.3 0.1 2.3 2 1 0 2 2 2 1 N-acetyltransferase PQQ_3 PF13570.6 ETS62806.1 - 3.4e-05 24.2 1.6 0.46 11.0 0.1 4.5 5 0 0 5 5 5 2 PQQ-like domain ANAPC4_WD40 PF12894.7 ETS62806.1 - 0.00034 20.8 0.2 0.61 10.4 0.0 3.5 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ETS62806.1 - 0.037 13.6 0.8 0.15 11.6 0.1 2.2 2 0 0 2 2 2 0 PQQ-like domain WD40 PF00400.32 ETS62806.1 - 0.044 14.7 20.3 1.2 10.2 0.3 6.3 6 1 0 6 6 6 0 WD domain, G-beta repeat CDC45 PF02724.14 ETS62806.1 - 0.17 10.1 2.1 0.23 9.7 2.1 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETS62806.1 - 2 8.1 3.6 3.2 7.4 3.6 1.2 1 0 0 1 1 1 0 FAM176 family PBP1_TM PF14812.6 ETS62806.1 - 3.4 8.1 8.6 5.9 7.3 8.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.9 ETS62806.1 - 5.8 5.9 10.3 9 5.3 10.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cactin_mid PF10312.9 ETS62807.1 - 1.3e-62 211.0 8.0 1.3e-62 211.0 8.0 2.1 2 0 0 2 2 2 1 Conserved mid region of cactin CactinC_cactus PF09732.9 ETS62807.1 - 1.3e-61 206.0 5.7 2.3e-61 205.3 5.7 1.4 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein AD PF09793.9 ETS62808.1 - 2.8e-19 69.0 0.0 7.2e-19 67.7 0.0 1.7 1 0 0 1 1 1 1 Anticodon-binding domain DUF3145 PF11343.8 ETS62808.1 - 0.014 15.0 0.2 0.24 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3145) NPC1_N PF16414.5 ETS62809.1 - 2e-78 263.3 9.0 3e-78 262.8 9.0 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 ETS62809.1 - 5.7e-61 206.6 1.3 6.6e-32 110.5 0.2 2.8 3 1 0 3 3 3 2 Patched family Sterol-sensing PF12349.8 ETS62809.1 - 1.1e-41 142.3 11.6 1.8e-20 73.3 0.4 3.5 3 0 0 3 3 3 2 Sterol-sensing domain of SREBP cleavage-activation Folate_rec PF03024.14 ETS62809.1 - 0.0016 18.3 1.2 0.0033 17.3 1.2 1.4 1 0 0 1 1 1 1 Folate receptor family ACR_tran PF00873.19 ETS62809.1 - 0.024 12.3 0.7 0.038 11.7 0.7 1.2 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family HemY_N PF07219.13 ETS62809.1 - 0.75 10.0 5.2 5.5 7.2 0.4 3.4 2 1 0 3 3 3 0 HemY protein N-terminus tRNA_anti-codon PF01336.25 ETS62811.1 - 0.063 13.3 0.0 0.5 10.4 0.0 2.0 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain CHZ PF09649.10 ETS62812.1 - 2.9e-11 42.6 0.2 2.9e-11 42.6 0.2 2.9 3 0 0 3 3 3 1 Histone chaperone domain CHZ Nucleo_P87 PF07267.11 ETS62812.1 - 0.47 9.3 4.9 0.58 8.9 4.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.12 ETS62812.1 - 0.74 8.0 15.9 0.83 7.8 15.9 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpb4 PF03874.16 ETS62813.1 - 2e-27 96.0 0.5 2.6e-27 95.6 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Ribosomal_L12_N PF16320.5 ETS62813.1 - 0.41 10.4 0.1 0.41 10.4 0.1 2.2 2 0 0 2 2 2 0 Ribosomal protein L7/L12 dimerisation domain WD40 PF00400.32 ETS62814.1 - 2.3e-26 91.5 10.1 1.1e-06 29.3 0.0 6.7 6 1 0 6 6 6 4 WD domain, G-beta repeat Sof1 PF04158.14 ETS62814.1 - 5.8e-25 87.4 7.3 1.1e-24 86.6 7.3 1.4 1 0 0 1 1 1 1 Sof1-like domain ANAPC4_WD40 PF12894.7 ETS62814.1 - 1.9e-05 24.9 0.0 9 6.7 0.0 4.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CBFB_NFYA PF02045.15 ETS62815.1 - 7.7e-22 77.7 12.4 7.7e-22 77.7 12.4 2.9 2 1 0 2 2 2 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B ThuA PF06283.11 ETS62816.1 - 1.9e-44 152.4 0.0 2.3e-44 152.1 0.0 1.1 1 0 0 1 1 1 1 Trehalose utilisation BPL_N PF09825.9 ETS62816.1 - 0.079 12.0 0.1 0.15 11.1 0.1 1.3 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF3446 PF11928.8 ETS62816.1 - 0.34 11.3 9.2 0.25 11.7 6.6 2.0 2 0 0 2 2 2 0 Early growth response N-terminal domain Sporozoite_P67 PF05642.11 ETS62816.1 - 0.7 7.9 6.7 0.92 7.5 6.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4871 PF16167.5 ETS62816.1 - 2.6 8.1 4.2 1.2 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4871) Kelch_4 PF13418.6 ETS62817.1 - 1.1e-32 111.8 3.7 2.2e-07 30.7 0.0 6.3 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 ETS62817.1 - 2.7e-27 94.5 4.4 2.5e-06 27.6 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ETS62817.1 - 7.1e-19 67.4 4.5 1.7e-05 24.7 0.0 5.9 6 0 0 6 6 6 3 Kelch motif DUF4110 PF13422.6 ETS62817.1 - 1.5e-18 66.6 0.5 1.5e-18 66.6 0.5 3.1 4 0 0 4 4 2 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.6 ETS62817.1 - 3.3e-16 58.9 6.9 0.00039 20.6 0.0 5.8 5 1 1 6 6 6 3 Kelch motif Kelch_1 PF01344.25 ETS62817.1 - 5e-15 54.8 3.5 5.4e-05 22.7 0.0 5.1 5 1 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETS62817.1 - 1.2e-12 47.3 0.7 0.018 15.0 0.0 5.2 6 0 0 6 6 6 3 Kelch motif BUD22 PF09073.10 ETS62817.1 - 0.0046 16.3 17.4 0.0046 16.3 17.4 2.2 2 0 0 2 2 2 1 BUD22 MCM_bind PF09739.9 ETS62817.1 - 0.016 13.7 0.5 0.016 13.7 0.5 2.1 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor Acetyltransf_6 PF13480.7 ETS62817.1 - 0.093 12.9 2.1 0.2 11.8 0.1 2.5 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DAP PF15228.6 ETS62817.1 - 1.4 10.1 19.4 0.17 13.0 3.4 2.6 2 0 0 2 2 2 0 Death-associated protein DDHD PF02862.17 ETS62817.1 - 4.9 7.2 16.2 2 8.5 0.1 2.7 2 1 0 2 2 2 0 DDHD domain Hep_59 PF07052.11 ETS62817.1 - 6.2 7.6 20.7 0.13 13.0 3.1 3.5 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 DUF4578 PF15147.6 ETS62817.1 - 6.7 7.6 12.8 0.58 11.0 2.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) ECH_1 PF00378.20 ETS62818.1 - 6.8e-20 71.4 0.0 1e-17 64.3 0.0 2.5 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS62818.1 - 2.6e-09 37.0 0.0 3.4e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF1731 PF08338.11 ETS62818.1 - 0.037 13.8 0.3 0.093 12.6 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1731) Myb_DNA-bind_2 PF08914.11 ETS62820.1 - 0.046 13.9 0.0 0.095 12.9 0.0 1.5 1 0 0 1 1 1 0 Rap1 Myb domain Actin PF00022.19 ETS62821.1 - 7.7e-128 426.6 0.0 3.7e-127 424.3 0.0 1.8 1 1 0 1 1 1 1 Actin adh_short_C2 PF13561.6 ETS62822.1 - 3.8e-63 213.2 1.2 6.3e-63 212.4 1.2 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1077 PF06417.12 ETS62822.1 - 5.9e-45 152.1 0.6 1.1e-44 151.3 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) adh_short PF00106.25 ETS62822.1 - 3.5e-44 150.6 1.2 6.7e-44 149.7 1.2 1.5 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS62822.1 - 1.5e-12 47.8 2.4 3.4e-12 46.6 2.4 1.5 1 0 0 1 1 1 1 KR domain AhpC-TSA_2 PF13911.6 ETS62822.1 - 7e-11 42.3 0.0 3.4e-10 40.0 0.0 2.1 2 0 0 2 2 2 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.10 ETS62822.1 - 0.0059 16.3 0.0 0.025 14.3 0.0 1.9 2 0 0 2 2 2 1 Redoxin DUF4658 PF15555.6 ETS62822.1 - 0.076 13.1 0.2 0.98 9.5 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4658) AhpC-TSA PF00578.21 ETS62822.1 - 0.078 12.9 0.0 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 AhpC/TSA family DHQ_synthase PF01761.20 ETS62823.1 - 1e-48 165.8 0.0 1.4e-48 165.4 0.0 1.1 1 0 0 1 1 1 1 3-dehydroquinate synthase Fe-ADH_2 PF13685.6 ETS62823.1 - 6e-11 42.5 0.0 8.5e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Rad17 PF03215.15 ETS62825.1 - 1.9e-19 70.3 0.0 1.3e-18 67.6 0.0 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 ETS62825.1 - 3.3e-05 24.3 1.8 0.00021 21.7 0.2 2.7 3 0 0 3 3 3 1 AAA ATPase domain AAA_assoc_2 PF16193.5 ETS62825.1 - 0.036 14.4 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain AAA_22 PF13401.6 ETS62825.1 - 0.096 13.0 0.0 0.25 11.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain IBN_N PF03810.19 ETS62826.1 - 3.6e-16 58.8 0.0 1.3e-15 57.1 0.0 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cse1 PF08506.10 ETS62826.1 - 4.9e-07 28.9 0.0 1.2e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Cse1 HEAT PF02985.22 ETS62826.1 - 0.042 14.1 0.3 3.9 8.0 0.0 4.2 3 0 0 3 3 3 0 HEAT repeat IL17_R_N PF15037.6 ETS62826.1 - 0.076 12.0 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Interleukin-17 receptor extracellular region Xpo1 PF08389.12 ETS62826.1 - 0.076 13.1 0.0 0.38 10.8 0.0 2.3 1 0 0 1 1 1 0 Exportin 1-like protein EF_assoc_2 PF08356.12 ETS62826.1 - 0.12 12.4 0.1 0.35 10.9 0.1 1.8 1 0 0 1 1 1 0 EF hand associated Translin PF01997.16 ETS62827.1 - 5.4e-44 150.6 0.0 6.5e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Translin family ATP-synt_D PF01813.17 ETS62827.1 - 0.072 12.9 0.8 2.8 7.7 0.0 2.7 2 1 0 2 2 2 0 ATP synthase subunit D MitMem_reg PF13012.6 ETS62827.1 - 0.11 12.9 0.1 0.7 10.3 0.1 2.1 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function ATP-synt_B PF00430.18 ETS62827.1 - 0.5 10.5 3.2 1.3 9.1 3.2 1.7 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Ribosomal_L1 PF00687.21 ETS62828.1 - 3.1e-53 180.6 0.0 5e-53 179.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF4336 PF14234.6 ETS62829.1 - 1.4e-08 34.3 0.2 0.18 11.0 0.0 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF4336) Rap1-DNA-bind PF09197.10 ETS62829.1 - 0.16 12.5 0.0 0.34 11.5 0.0 1.5 1 0 0 1 1 1 0 Rap1, DNA-binding IML1 PF12257.8 ETS62831.1 - 1.8e-114 381.7 0.1 3.6e-114 380.7 0.0 1.6 2 0 0 2 2 2 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 ETS62831.1 - 1.8e-18 66.4 0.2 3.8e-18 65.3 0.2 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PAP2_3 PF14378.6 ETS62832.1 - 1.8e-19 70.2 18.6 1.8e-19 70.2 18.6 2.3 1 1 1 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 ETS62832.1 - 8.8e-09 35.2 12.2 8.8e-09 35.2 12.2 2.3 2 1 1 3 3 3 1 PAP2 superfamily DUF4449 PF14613.6 ETS62833.1 - 2.1e-06 27.9 0.0 2.1e-06 27.9 0.0 5.2 4 2 1 5 5 5 1 Protein of unknown function (DUF4449) Nexin_C PF08628.12 ETS62833.1 - 0.011 16.3 0.7 0.049 14.2 0.0 2.5 2 0 0 2 2 2 0 Sorting nexin C terminal TetR_C_22 PF17928.1 ETS62833.1 - 0.025 14.9 1.8 6.3 7.2 0.1 3.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4420 PF14390.6 ETS62833.1 - 0.049 12.9 1.7 0.17 11.1 0.3 2.2 2 0 0 2 2 2 0 Putative PD-(D/E)XK family member, (DUF4420) ApoLp-III PF07464.11 ETS62833.1 - 0.049 13.7 16.5 1.8 8.7 0.7 3.9 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Katanin_con80 PF13925.6 ETS62833.1 - 0.13 12.3 0.2 0.38 10.8 0.0 1.9 2 0 0 2 2 1 0 con80 domain of Katanin PhoU_div PF01865.16 ETS62833.1 - 0.22 10.8 3.0 0.45 9.8 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF47 Nif11 PF07862.11 ETS62833.1 - 0.47 10.8 11.2 14 6.1 0.0 5.7 6 0 0 6 6 6 0 Nif11 domain Prominin PF05478.11 ETS62833.1 - 1.5 6.7 4.5 0.89 7.4 0.3 2.4 2 1 0 3 3 3 0 Prominin DUF883 PF05957.13 ETS62833.1 - 2.1 9.0 40.9 0.96 10.1 4.5 6.7 5 2 3 8 8 8 0 Bacterial protein of unknown function (DUF883) Syntaxin-6_N PF09177.11 ETS62833.1 - 3.5 8.2 11.7 3.8 8.1 0.4 4.4 3 1 2 5 5 5 0 Syntaxin 6, N-terminal AF0941-like PF14591.6 ETS62833.1 - 4.2 8.0 5.7 23 5.6 1.7 2.9 2 0 0 2 2 2 0 AF0941-like DUF445 PF04286.12 ETS62833.1 - 6 6.6 13.6 3.1 7.5 8.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF445) Acetyltransf_1 PF00583.25 ETS62834.1 - 5.3e-14 52.5 0.0 7.2e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ETS62834.1 - 2.2e-09 37.1 0.1 3.7e-09 36.4 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ETS62834.1 - 5.7e-09 36.0 0.1 8.9e-09 35.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS62834.1 - 2.6e-08 34.2 0.0 3.6e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ETS62834.1 - 8.1e-06 25.6 0.1 2.2e-05 24.2 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETS62834.1 - 2.3e-05 24.5 0.1 3.5e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ETS62834.1 - 0.00014 22.6 0.0 0.00017 22.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETS62834.1 - 0.0023 18.0 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase GNAT_acetyltran PF12746.7 ETS62834.1 - 0.099 12.2 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase Acetyltransf_13 PF13880.6 ETS62834.1 - 0.14 12.1 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Aminotran_1_2 PF00155.21 ETS62836.1 - 2.4e-33 115.8 0.0 6.2e-33 114.4 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETS62836.1 - 0.0003 20.2 0.0 0.00048 19.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_3 PF00202.21 ETS62836.1 - 0.17 10.5 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class-III TPR_1 PF00515.28 ETS62837.1 - 3.4e-12 45.6 7.0 1.7e-05 24.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat RPAP3_C PF13877.6 ETS62837.1 - 1.9e-09 38.0 0.0 3.2e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_2 PF07719.17 ETS62837.1 - 6.1e-07 29.1 17.4 0.0032 17.4 0.1 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETS62837.1 - 3.2e-06 26.7 4.5 0.085 12.6 1.3 3.3 3 0 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 ETS62837.1 - 3.5e-06 27.4 11.3 0.033 14.7 0.5 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETS62837.1 - 0.00014 21.8 0.3 1.2 9.5 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS62837.1 - 0.0002 22.0 1.9 0.0002 22.0 1.9 3.9 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETS62837.1 - 0.0013 18.8 1.1 0.0045 17.1 0.5 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS62837.1 - 0.01 16.2 3.3 0.013 15.9 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETS62837.1 - 0.016 15.3 0.5 0.64 10.1 0.1 2.4 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 ETS62837.1 - 0.017 15.4 4.7 0.2 12.0 0.4 3.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETS62837.1 - 0.3 12.0 10.0 0.35 11.8 2.1 4.1 2 1 2 4 4 4 0 Tetratricopeptide repeat YfdX PF10938.8 ETS62837.1 - 3.2 7.7 9.1 0.15 11.9 0.3 2.6 2 1 1 3 3 3 0 YfdX protein TPR_20 PF14561.6 ETS62837.1 - 4.4 7.7 6.9 2.6 8.4 1.7 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM176 PF14851.6 ETS62838.1 - 0.81 9.3 8.7 0.93 9.2 0.1 2.1 2 0 0 2 2 2 0 FAM176 family TraQ PF09679.10 ETS62838.1 - 1.4 8.9 4.8 25 4.9 4.8 2.4 1 1 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) ATP-synt_ab PF00006.25 ETS62839.1 - 9.4e-66 221.5 0.0 1.5e-65 220.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain DAO PF01266.24 ETS62839.1 - 8e-50 170.4 0.4 1.6e-49 169.4 0.4 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 ETS62839.1 - 3.5e-45 152.9 0.0 1.2e-44 151.2 0.0 2.0 2 0 0 2 2 2 1 C-terminal domain of alpha-glycerophosphate oxidase ATP-synt_ab_N PF02874.23 ETS62839.1 - 5.5e-13 49.2 0.3 1.4e-12 47.9 0.3 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain EF-hand_7 PF13499.6 ETS62839.1 - 3.8e-09 36.9 1.2 1.1e-08 35.4 1.2 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETS62839.1 - 1.3e-07 30.9 1.7 1.3e-05 24.7 0.3 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ETS62839.1 - 7.1e-06 25.2 0.8 0.0011 18.4 0.2 2.7 2 0 0 2 2 2 1 EF hand FAD_oxidored PF12831.7 ETS62839.1 - 2.6e-05 23.8 1.5 5.8e-05 22.6 0.3 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ETS62839.1 - 0.00047 19.5 0.7 0.0033 16.7 0.7 2.0 1 1 0 1 1 1 1 FAD binding domain EF-hand_8 PF13833.6 ETS62839.1 - 0.00049 19.9 2.4 0.0014 18.5 0.7 2.8 3 0 0 3 3 3 1 EF-hand domain pair GIDA PF01134.22 ETS62839.1 - 0.0018 17.5 0.3 0.057 12.5 0.2 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A EF-hand_5 PF13202.6 ETS62839.1 - 0.0023 17.3 0.3 0.0061 16.0 0.3 1.8 1 0 0 1 1 1 1 EF hand Pyr_redox_2 PF07992.14 ETS62839.1 - 0.0045 16.3 0.4 0.014 14.6 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS62839.1 - 0.017 14.3 5.9 0.0095 15.1 3.5 1.9 2 1 0 2 2 2 0 FAD binding domain Dockerin_1 PF00404.18 ETS62839.1 - 0.018 15.3 3.1 0.3 11.3 0.0 2.8 2 0 0 2 2 2 0 Dockerin type I domain DUF3533 PF12051.8 ETS62839.1 - 0.022 13.7 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) EF-hand_9 PF14658.6 ETS62839.1 - 0.04 14.3 0.1 0.085 13.2 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain 3HCDH_N PF02737.18 ETS62839.1 - 0.078 12.9 0.3 0.21 11.4 0.3 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF2666 PF10869.8 ETS62839.1 - 0.09 13.0 0.5 13 6.0 0.0 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) HI0933_like PF03486.14 ETS62839.1 - 0.18 10.5 1.0 0.32 9.6 1.0 1.4 1 0 0 1 1 1 0 HI0933-like protein SPARC_Ca_bdg PF10591.9 ETS62839.1 - 0.32 11.3 0.9 0.65 10.3 0.1 1.9 2 0 0 2 2 1 0 Secreted protein acidic and rich in cysteine Ca binding region NAD_binding_8 PF13450.6 ETS62839.1 - 1.1 9.6 3.9 0.85 9.9 0.4 2.8 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Brix PF04427.18 ETS62841.1 - 4.2e-29 102.0 0.3 5.4e-29 101.7 0.3 1.1 1 0 0 1 1 1 1 Brix domain Ribosomal_L28 PF00830.19 ETS62842.1 - 5.3e-20 71.4 0.2 9.5e-20 70.6 0.2 1.4 1 0 0 1 1 1 1 Ribosomal L28 family PIN_4 PF13638.6 ETS62843.1 - 0.0005 20.4 0.0 0.00099 19.4 0.0 1.4 1 0 0 1 1 1 1 PIN domain LCE6A PF15858.5 ETS62843.1 - 4.4 8.1 7.7 11 6.9 1.5 2.9 2 0 0 2 2 2 0 Late cornified envelope protein 6A family Sec23_trunk PF04811.15 ETS62844.1 - 1.5e-76 257.2 0.0 2.1e-76 256.7 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ETS62844.1 - 1.3e-30 106.0 0.0 2.3e-30 105.2 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ETS62844.1 - 4.4e-26 90.7 0.1 9.8e-26 89.6 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ETS62844.1 - 7.1e-16 58.0 6.2 1.4e-15 57.0 6.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ETS62844.1 - 8.4e-12 44.8 0.0 1.8e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ETS62844.1 - 0.12 11.8 0.1 0.24 10.8 0.1 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Pam16 PF03656.13 ETS62845.1 - 0.00011 22.2 0.0 0.0002 21.4 0.0 1.5 2 0 0 2 2 2 1 Pam16 DnaJ PF00226.31 ETS62845.1 - 0.00011 22.2 0.0 0.00018 21.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain WD40 PF00400.32 ETS62846.1 - 1.2e-07 32.3 5.7 1.5 9.8 0.0 5.5 4 1 1 5 5 5 3 WD domain, G-beta repeat Ank_2 PF12796.7 ETS62846.1 - 0.12 13.0 0.0 12 6.6 0.0 2.5 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) Use1 PF09753.9 ETS62847.1 - 0.023 14.5 0.0 0.049 13.3 0.0 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 DUF4316 PF14195.6 ETS62847.1 - 0.041 13.6 0.1 0.074 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) DPBB_1 PF03330.18 ETS62848.1 - 9.4e-06 25.8 0.1 1.7e-05 25.0 0.1 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ETS62848.1 - 0.0023 17.8 0.4 0.0043 16.9 0.4 1.4 1 0 0 1 1 1 1 Barwin family TIM21 PF08294.11 ETS62849.1 - 5.5e-14 52.3 0.0 1.8e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 TIM21 Transposase_23 PF03017.14 ETS62849.1 - 0.064 13.2 0.0 0.21 11.6 0.0 1.8 1 0 0 1 1 1 0 TNP1/EN/SPM transposase OapA PF04225.12 ETS62849.1 - 0.15 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 Opacity-associated protein A LysM-like domain Yippee-Mis18 PF03226.14 ETS62850.1 - 7e-16 58.4 0.1 8.3e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 ETS62850.1 - 0.0095 16.2 0.2 0.014 15.7 0.2 1.3 1 1 0 1 1 1 1 C-terminal domain of RIG-I PBP1_TM PF14812.6 ETS62851.1 - 0.073 13.5 4.6 0.12 12.7 4.6 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4746 PF15928.5 ETS62851.1 - 0.1 12.0 0.4 7.4 5.9 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) FAM176 PF14851.6 ETS62851.1 - 0.12 12.1 2.1 0.24 11.0 2.1 1.6 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 ETS62851.1 - 0.22 10.7 1.3 0.35 10.0 1.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Str_synth PF03088.16 ETS62852.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Strictosidine synthase Arylesterase PF01731.20 ETS62852.1 - 0.21 11.8 0.0 7.3 6.9 0.0 2.5 2 0 0 2 2 2 0 Arylesterase DUF3678 PF12435.8 ETS62852.1 - 0.65 9.4 7.5 7.2 6.1 1.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) Ribosomal_L19e PF01280.20 ETS62853.1 - 4.3e-61 205.2 9.5 4.3e-61 205.2 9.5 1.7 2 0 0 2 2 2 1 Ribosomal protein L19e Ribosomal_S27e PF01667.17 ETS62854.1 - 1.5e-26 91.9 4.6 1.5e-26 91.9 4.6 1.8 2 0 0 2 2 2 1 Ribosomal protein S27 HapK PF11639.8 ETS62854.1 - 0.015 15.8 0.1 0.027 15.0 0.1 1.4 1 0 0 1 1 1 0 REDY-like protein HapK TF_Zn_Ribbon PF08271.12 ETS62854.1 - 0.11 12.0 0.4 0.21 11.1 0.4 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Zn_ribbon_SprT PF17283.2 ETS62854.1 - 0.13 12.1 5.1 0.39 10.7 0.1 2.9 2 1 0 2 2 2 0 SprT-like zinc ribbon domain DHHC PF01529.20 ETS62855.1 - 4.9e-35 120.5 14.0 4.9e-35 120.5 14.0 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase QueC PF06508.13 ETS62855.1 - 5 6.6 5.3 7.9 5.9 5.3 1.2 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Synaptobrevin PF00957.21 ETS62856.1 - 3.4e-14 52.4 0.7 6.4e-14 51.5 0.7 1.4 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ETS62856.1 - 2.4e-12 46.7 0.0 4.3e-12 45.9 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Herpes_teg_N PF04843.12 ETS62856.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus tegument protein, N-terminal conserved region CENP-L PF13092.6 ETS62857.1 - 4e-09 36.9 0.0 1.3e-08 35.2 0.0 1.9 1 1 0 1 1 1 1 Kinetochore complex Sim4 subunit Fta1 Glucan_synthase PF02364.15 ETS62858.1 - 0 1306.0 0.0 0 1305.5 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 ETS62858.1 - 1.6e-40 138.4 0.0 3.9e-40 137.2 0.0 1.7 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF2157 PF09925.9 ETS62858.1 - 8.3 6.2 15.3 0.26 11.1 1.7 3.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) Glyco_hydro_72 PF03198.14 ETS62859.1 - 1.8e-94 316.5 0.0 2.6e-94 316.0 0.0 1.2 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ETS62859.1 - 6.6e-18 65.2 1.0 6.6e-18 65.2 1.0 1.8 2 0 0 2 2 2 1 X8 domain Cellulase PF00150.18 ETS62859.1 - 7.3e-05 22.3 0.0 0.00029 20.4 0.0 1.9 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) GyrI-like PF06445.15 ETS62860.1 - 0.13 12.6 0.0 3.2 8.1 0.0 2.3 1 1 1 2 2 2 0 GyrI-like small molecule binding domain Iwr1 PF08574.10 ETS62861.1 - 6.9e-07 30.2 10.0 2.5e-06 28.4 7.5 3.9 4 0 0 4 4 4 2 Transcription factor Iwr1 Ras PF00071.22 ETS62863.1 - 1.3e-54 184.1 0.0 1.5e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS62863.1 - 1.7e-20 73.5 0.0 2.7e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS62863.1 - 2.4e-07 30.4 0.0 2.7e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS62863.1 - 0.00043 19.9 0.2 0.0029 17.2 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETS62863.1 - 0.0016 18.4 0.2 0.52 10.2 0.0 2.2 1 1 1 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ETS62863.1 - 0.0076 15.6 0.0 0.0096 15.3 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ETS62863.1 - 0.013 15.0 0.1 0.083 12.4 0.1 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B CbiA PF01656.23 ETS62863.1 - 0.022 14.8 0.3 0.11 12.6 0.3 1.9 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 ETS62863.1 - 0.13 12.6 0.1 0.23 11.8 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ETS62863.1 - 0.13 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain zf-C2H2_8 PF15909.5 ETS62864.1 - 0.0052 17.1 2.9 0.011 16.0 2.9 1.5 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2 PF00096.26 ETS62864.1 - 0.017 15.6 2.3 0.017 15.6 2.3 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ETS62864.1 - 0.02 14.9 0.8 0.02 14.9 0.8 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ETS62864.1 - 1.8 9.6 15.7 0.21 12.5 1.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Vta1 PF04652.16 ETS62865.1 - 4.4e-52 175.9 2.5 6e-52 175.5 2.5 1.2 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 ETS62865.1 - 1.3e-12 47.1 0.3 1.3e-12 47.1 0.3 1.8 2 0 0 2 2 2 1 Vta1 C-terminal domain MCM PF00493.23 ETS62866.1 - 9.1e-99 329.1 0.0 1.3e-98 328.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETS62866.1 - 7.8e-38 129.2 0.8 1.3e-37 128.4 0.8 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETS62866.1 - 1.7e-26 92.4 2.5 3.9e-26 91.3 2.5 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ETS62866.1 - 5.3e-17 62.3 0.0 1.5e-16 60.8 0.0 1.8 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 ETS62866.1 - 4.9e-08 33.1 0.0 2e-07 31.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETS62866.1 - 4.5e-07 29.4 0.1 0.00025 20.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETS62866.1 - 0.00027 20.8 0.1 0.021 14.7 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETS62866.1 - 0.0063 16.2 0.2 1.1 9.0 0.0 2.9 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_16 PF13191.6 ETS62866.1 - 0.011 16.1 0.8 0.15 12.5 0.8 3.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_lid_2 PF17863.1 ETS62866.1 - 0.053 13.4 0.2 0.13 12.2 0.2 1.6 1 0 0 1 1 1 0 AAA lid domain WD40 PF00400.32 ETS62867.1 - 7.8e-18 64.5 5.9 6.5e-05 23.6 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62867.1 - 2.6e-15 56.5 3.2 0.00014 22.1 0.1 5.1 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS62867.1 - 3e-06 26.4 0.0 0.00037 19.5 0.0 3.1 2 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETS62867.1 - 7.8e-06 25.9 0.1 0.0016 18.4 0.0 2.9 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETS62867.1 - 0.0013 18.1 0.2 0.0077 15.6 0.1 2.1 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.12 ETS62867.1 - 0.022 12.8 0.1 2.6 5.9 0.1 2.5 2 1 0 2 2 2 0 IKI3 family DUF3512 PF12024.8 ETS62868.1 - 1.7e-05 24.4 0.1 4e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) zf-CCCH PF00642.24 ETS62869.1 - 1.5e-14 53.5 15.4 5e-09 35.9 2.0 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS62869.1 - 2.7e-06 27.2 4.7 2.7e-06 27.2 4.7 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ETS62869.1 - 0.00044 20.0 2.0 0.00044 20.0 2.0 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger oligo_HPY PF08352.12 ETS62869.1 - 0.15 12.6 6.0 2.4 8.7 0.3 2.5 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region Defensin_int PF17858.1 ETS62869.1 - 0.5 10.4 4.3 0.76 9.8 1.5 2.3 2 0 0 2 2 2 0 Platypus intermediate defensin-like peptide zf-CCCH_3 PF15663.5 ETS62869.1 - 4.1 7.7 9.2 15 5.8 2.0 2.3 1 1 1 2 2 2 0 Zinc-finger containing family Torus PF16131.5 ETS62869.1 - 6.5 7.5 10.9 0.21 12.3 0.9 2.4 1 1 1 2 2 2 0 Torus domain DUF2418 PF10332.9 ETS62870.1 - 4.6e-23 81.6 1.0 6e-23 81.2 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) Ras PF00071.22 ETS62871.1 - 7.1e-62 207.8 0.1 8.4e-62 207.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS62871.1 - 8.3e-34 116.4 0.1 1.3e-33 115.8 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS62871.1 - 2.1e-12 46.9 0.0 2.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS62871.1 - 5.2e-06 26.5 0.0 8.9e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS62871.1 - 0.00017 21.2 0.1 0.001 18.6 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETS62871.1 - 0.0014 18.5 0.1 0.15 12.0 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ETS62871.1 - 0.0034 17.7 0.1 0.041 14.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 ETS62871.1 - 0.0034 16.9 0.0 0.0068 15.9 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ETS62871.1 - 0.0061 17.0 0.1 0.01 16.3 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 ETS62871.1 - 0.011 15.1 0.1 0.023 14.0 0.1 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ETS62871.1 - 0.018 14.8 0.0 0.067 12.9 0.0 1.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ETS62871.1 - 0.034 14.7 0.2 0.044 14.3 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ETS62871.1 - 0.037 13.5 0.1 0.085 12.4 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 ETS62871.1 - 0.048 13.9 0.2 0.3 11.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETS62871.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ETS62871.1 - 0.067 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TniB PF05621.11 ETS62871.1 - 0.076 12.4 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein MCM PF00493.23 ETS62871.1 - 0.079 12.1 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_5 PF07728.14 ETS62871.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AEP1 PF17049.5 ETS62871.1 - 0.14 11.2 0.0 0.2 10.7 0.0 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 Xpo1 PF08389.12 ETS62872.1 - 7e-23 81.3 0.0 2.3e-21 76.4 0.0 3.3 3 1 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 ETS62872.1 - 4.1e-06 26.6 0.1 2.1e-05 24.3 0.3 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain AAA PF00004.29 ETS62873.1 - 4.4e-41 140.4 0.0 8.2e-41 139.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ETS62873.1 - 1.7e-29 101.6 0.4 7.4e-29 99.5 0.1 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ETS62873.1 - 2.1e-24 85.3 7.8 6.4e-24 83.8 7.8 1.9 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 ETS62873.1 - 1e-08 34.8 0.0 2.4e-07 30.5 0.0 2.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_16 PF13191.6 ETS62873.1 - 2.1e-05 24.9 0.8 0.0032 17.9 0.1 3.3 3 1 1 4 4 4 1 AAA ATPase domain TIP49 PF06068.13 ETS62873.1 - 6.8e-05 22.2 0.4 0.00015 21.1 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain RNA_helicase PF00910.22 ETS62873.1 - 8.5e-05 22.9 0.1 0.018 15.4 0.0 3.3 3 0 0 3 3 3 1 RNA helicase AAA_22 PF13401.6 ETS62873.1 - 0.0001 22.6 0.6 0.028 14.7 0.1 2.8 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ETS62873.1 - 0.0001 22.1 0.0 0.00019 21.2 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ETS62873.1 - 0.00021 21.1 0.0 0.00053 19.8 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 ETS62873.1 - 0.00026 21.0 0.0 0.00085 19.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ETS62873.1 - 0.00035 20.7 0.1 0.0011 19.1 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 ETS62873.1 - 0.0011 19.0 0.3 0.0045 17.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ETS62873.1 - 0.0019 18.3 0.1 0.0081 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ETS62873.1 - 0.002 17.3 0.0 0.0044 16.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.6 ETS62873.1 - 0.0087 16.5 0.1 0.033 14.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETS62873.1 - 0.011 15.1 0.0 0.026 13.9 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ETS62873.1 - 0.014 15.0 0.1 0.79 9.3 0.1 2.5 1 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETS62873.1 - 0.015 15.8 0.2 0.063 13.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETS62873.1 - 0.019 14.7 0.1 0.12 12.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ETS62873.1 - 0.021 14.1 0.0 5.6 6.2 0.0 2.3 1 1 1 2 2 2 0 KaiC AFG1_ATPase PF03969.16 ETS62873.1 - 0.063 12.2 0.1 1.7 7.5 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase Sigma54_activat PF00158.26 ETS62873.1 - 0.083 12.6 0.0 0.5 10.1 0.0 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 ETS62873.1 - 0.1 12.5 0.1 0.78 9.6 0.0 2.4 2 1 1 3 3 3 0 NACHT domain PhoH PF02562.16 ETS62873.1 - 0.12 11.8 0.1 0.3 10.5 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activ_2 PF14532.6 ETS62873.1 - 0.17 12.0 0.0 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain Vps39_2 PF10367.9 ETS62874.1 - 1.1e-10 41.9 0.1 3.7e-10 40.2 0.1 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 ETS62874.1 - 0.00021 21.6 0.1 0.0015 18.8 0.0 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 ETS62874.1 - 0.043 13.4 0.0 0.22 11.1 0.0 2.1 1 1 0 1 1 1 0 CNH domain Adeno_shaft PF00608.17 ETS62874.1 - 0.12 12.2 0.1 0.3 10.9 0.1 1.7 1 0 0 1 1 1 0 Adenoviral fibre protein (repeat/shaft region) zf-C2H2 PF00096.26 ETS62876.1 - 5.5e-06 26.5 12.7 0.0027 18.1 1.6 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS62876.1 - 8.8e-05 23.0 12.7 0.01 16.6 1.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETS62876.1 - 0.0014 18.6 2.2 0.0016 18.4 0.5 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETS62876.1 - 0.0032 17.8 11.1 0.22 12.0 2.7 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ETS62876.1 - 0.34 11.3 10.7 0.34 11.2 0.9 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Mito_carr PF00153.27 ETS62878.1 - 6.3e-58 192.7 1.1 5.9e-20 71.0 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3792 PF12670.7 ETS62878.1 - 0.11 12.7 2.9 1.5 9.0 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) Phage_coat PF09063.10 ETS62879.1 - 0.089 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Phage PP7 coat protein CLN3 PF02487.17 ETS62879.1 - 0.14 11.1 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 CLN3 protein Osw5 PF17062.5 ETS62879.1 - 0.16 12.1 0.3 0.34 11.0 0.3 1.4 1 0 0 1 1 1 0 Outer spore wall 5 Inositol_P PF00459.25 ETS62880.1 - 4.4e-53 180.5 0.1 5.7e-52 176.9 0.1 2.0 1 1 0 1 1 1 1 Inositol monophosphatase family Pkinase PF00069.25 ETS62881.1 - 4.8e-64 216.3 0.0 6.8e-64 215.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62881.1 - 3.1e-46 157.8 0.0 4.8e-46 157.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase LIM PF00412.22 ETS62881.1 - 1e-12 48.1 31.6 7.1e-10 39.0 2.2 3.9 4 0 0 4 4 4 3 LIM domain Kinase-like PF14531.6 ETS62881.1 - 9.2e-06 25.2 0.0 4e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ETS62881.1 - 0.0053 16.7 1.0 0.28 11.0 0.0 3.3 3 0 0 3 3 3 1 Phosphotransferase enzyme family Ras_bdg_2 PF14847.6 ETS62881.1 - 0.018 15.4 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 Ras-binding domain of Byr2 WRC PF08879.10 ETS62881.1 - 0.019 14.6 0.2 7.9 6.3 0.0 2.7 2 0 0 2 2 2 0 WRC Kdo PF06293.14 ETS62881.1 - 0.026 13.9 0.1 0.072 12.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETS62881.1 - 0.12 11.2 0.0 0.22 10.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain RXT2_N PF08595.11 ETS62882.1 - 0.0061 16.6 0.8 0.0061 16.6 0.8 4.2 2 1 0 2 2 2 1 RXT2-like, N-terminal DUF572 PF04502.13 ETS62883.1 - 4.2 6.9 33.7 4.3 6.9 23.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF572) PCI PF01399.27 ETS62884.1 - 1.1e-05 25.8 0.0 2.6e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain LIP PF03583.14 ETS62887.1 - 1.5e-66 224.6 0.1 2.1e-66 224.2 0.1 1.1 1 0 0 1 1 1 1 Secretory lipase Hydrolase_4 PF12146.8 ETS62887.1 - 0.13 11.5 0.1 0.29 10.4 0.1 1.6 1 1 0 1 1 1 0 Serine aminopeptidase, S33 DUF5427 PF10310.9 ETS62888.1 - 1.6e-45 155.9 11.1 2.4e-43 148.8 6.5 2.5 1 1 1 2 2 2 2 Family of unknown function (DUF5427) Ndc1_Nup PF09531.10 ETS62888.1 - 1.2 7.8 5.5 1.5 7.4 5.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sugar_tr PF00083.24 ETS62889.1 - 3.5e-58 197.6 14.3 2e-57 195.1 14.3 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS62889.1 - 1.4e-16 60.4 24.5 1.4e-16 60.4 24.5 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily BLM10_mid PF16507.5 ETS62890.1 - 5.2e-173 576.5 0.0 9.3e-173 575.6 0.0 1.4 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 ETS62890.1 - 1.7e-25 88.8 0.5 7.6e-24 83.4 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF3437) HEAT PF02985.22 ETS62890.1 - 0.00048 20.2 0.1 0.005 17.0 0.1 3.0 1 0 0 1 1 1 1 HEAT repeat HEAT_EZ PF13513.6 ETS62890.1 - 0.0029 18.1 0.1 0.013 16.0 0.1 2.1 1 0 0 1 1 1 1 HEAT-like repeat Arm PF00514.23 ETS62890.1 - 0.0032 17.5 0.1 0.014 15.4 0.1 2.2 1 0 0 1 1 1 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETS62890.1 - 0.0043 17.4 1.3 0.02 15.2 0.0 2.9 2 0 0 2 2 2 1 HEAT repeats BLM10_N PF16547.5 ETS62890.1 - 0.0064 16.8 0.1 0.018 15.3 0.1 1.7 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal TAF6_C PF07571.13 ETS62890.1 - 0.011 16.0 0.4 0.28 11.5 0.0 2.8 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain Vac14_Fab1_bd PF12755.7 ETS62890.1 - 0.1 13.2 0.1 0.58 10.8 0.1 2.3 1 0 0 1 1 1 0 Vacuolar 14 Fab1-binding region Cut8 PF08559.10 ETS62891.1 - 1.6e-14 54.2 0.7 3.9e-13 49.6 0.4 2.7 2 1 0 2 2 2 1 Cut8, nuclear proteasome tether protein ORC6 PF05460.13 ETS62891.1 - 4.1 6.6 7.6 1.2 8.3 2.3 2.3 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Pkinase PF00069.25 ETS62893.1 - 1.6e-74 250.6 0.0 1.8e-74 250.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS62893.1 - 2.6e-35 122.0 0.0 3.3e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETS62893.1 - 0.00026 20.1 0.0 0.0024 16.9 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETS62893.1 - 0.042 13.8 0.0 0.13 12.2 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ETS62893.1 - 0.068 12.5 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Seadorna_VP7 PF07387.11 ETS62893.1 - 0.077 12.0 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Utp12 PF04003.12 ETS62894.1 - 5.5e-24 84.5 0.3 9.7e-24 83.7 0.3 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 ETS62894.1 - 0.0013 19.5 6.2 0.0076 17.1 0.2 3.6 3 0 0 3 3 3 1 WD domain, G-beta repeat CoA_binding PF02629.19 ETS62895.1 - 2.7e-28 98.5 0.1 6.7e-28 97.2 0.1 1.7 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 ETS62895.1 - 6.7e-20 71.5 0.2 1.3e-19 70.5 0.2 1.5 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 ETS62895.1 - 2.5e-08 33.8 0.1 5.9e-08 32.6 0.0 1.7 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 ETS62895.1 - 0.00013 22.4 0.0 0.00038 20.9 0.0 1.8 2 0 0 2 2 2 1 CoA binding domain HNH_3 PF13392.6 ETS62896.1 - 0.00094 18.9 0.7 0.0015 18.2 0.7 1.3 1 0 0 1 1 1 1 HNH endonuclease TAP_C PF03943.13 ETS62897.1 - 1.4e-15 56.6 0.8 1.4e-15 56.6 0.8 1.8 2 0 0 2 2 2 1 TAP C-terminal domain LRR_9 PF14580.6 ETS62897.1 - 5.7e-06 26.0 0.0 9.4e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ETS62897.1 - 0.002 18.5 4.4 0.0044 17.4 1.1 2.5 1 1 1 2 2 2 1 Leucine Rich repeats (2 copies) NTF2 PF02136.20 ETS62897.1 - 0.03 14.9 0.1 0.4 11.3 0.1 2.4 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain LRR_8 PF13855.6 ETS62897.1 - 0.037 13.8 3.1 0.26 11.1 3.1 2.4 1 1 0 1 1 1 0 Leucine rich repeat MMR_HSR1_Xtn PF16897.5 ETS62898.1 - 4.6e-39 132.7 1.4 8.1e-39 131.9 1.4 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 ETS62898.1 - 1.1e-19 70.6 0.0 2.5e-19 69.4 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 ETS62898.1 - 6.6e-19 67.7 0.1 1.3e-18 66.8 0.1 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 ETS62898.1 - 1.4e-11 44.2 0.0 2.8e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ETS62898.1 - 0.016 15.3 2.2 0.93 9.5 0.0 2.6 2 1 1 3 3 3 0 Dynamin family AIG1 PF04548.16 ETS62898.1 - 0.033 13.5 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 AIG1 family ATF7IP_BD PF16788.5 ETS62898.1 - 0.035 14.2 0.3 0.085 13.0 0.3 1.5 1 0 0 1 1 1 0 ATF-interacting protein binding domain TMA7 PF09072.10 ETS62898.1 - 0.17 12.7 2.0 0.32 11.9 2.0 1.4 1 0 0 1 1 1 0 Translation machinery associated TMA7 CBS PF00571.28 ETS62899.1 - 1.3e-27 96.0 8.6 7.1e-07 29.6 0.3 5.7 5 1 0 5 5 5 4 CBS domain PB1 PF00564.24 ETS62899.1 - 9e-07 28.7 0.0 2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 PB1 domain DUF4288 PF14119.6 ETS62899.1 - 0.096 13.1 2.0 31 5.1 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4288) DUF2380 PF09533.10 ETS62899.1 - 0.35 10.5 6.4 2.6 7.6 0.0 3.1 3 0 0 3 3 3 0 Predicted lipoprotein of unknown function (DUF2380) Zn_clus PF00172.18 ETS62900.1 - 4.4e-06 26.7 11.3 8.1e-06 25.9 11.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS62900.1 - 0.006 15.6 0.1 0.014 14.5 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain BCAS2 PF05700.11 ETS62902.1 - 4.3e-67 225.8 4.4 5.6e-67 225.4 4.4 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) Mesd PF10185.9 ETS62902.1 - 0.0078 16.2 0.2 0.014 15.4 0.2 1.4 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor DUF5320 PF17253.2 ETS62902.1 - 0.029 15.4 3.6 0.95 10.6 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Erythro-docking PF09277.11 ETS62902.1 - 0.031 14.2 1.5 0.72 9.8 0.2 2.7 2 0 0 2 2 2 0 Erythronolide synthase, docking Enkurin PF13864.6 ETS62902.1 - 0.16 12.4 8.0 0.3 11.5 7.5 1.7 1 1 0 1 1 1 0 Calmodulin-binding Nup54 PF13874.6 ETS62902.1 - 0.18 11.9 12.7 0.21 11.7 10.4 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 JIP_LZII PF16471.5 ETS62902.1 - 1.7 8.9 8.8 0.95 9.7 1.1 2.6 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II GIT_CC PF16559.5 ETS62902.1 - 5.9 6.8 10.6 9.8 6.1 1.2 2.8 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor NPV_P10 PF05531.12 ETS62902.1 - 6.6 7.3 6.8 12 6.4 1.4 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.5 ETS62902.1 - 8.2 6.8 16.0 4.5 7.6 1.0 3.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain Swi5 PF07061.11 ETS62902.1 - 8.3 6.6 8.9 47 4.2 1.5 3.3 3 0 0 3 3 3 0 Swi5 Complex1_30kDa PF00329.19 ETS62903.1 - 2.4e-46 157.3 0.0 3.3e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Arm PF00514.23 ETS62904.1 - 0.00021 21.2 31.7 0.00022 21.2 0.3 8.7 11 0 0 11 11 11 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETS62904.1 - 0.0064 17.0 21.0 0.016 15.7 0.1 7.6 8 0 0 8 8 8 2 HEAT-like repeat HEAT PF02985.22 ETS62904.1 - 0.017 15.3 21.5 0.17 12.2 0.1 7.9 8 0 0 8 8 8 0 HEAT repeat MCM PF00493.23 ETS62905.1 - 6.5e-98 326.3 0.1 9.8e-98 325.7 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETS62905.1 - 4e-31 107.5 0.0 7e-31 106.7 0.0 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETS62905.1 - 2.4e-23 82.4 0.6 1e-22 80.4 0.6 2.0 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ETS62905.1 - 7.4e-13 49.0 0.3 2.9e-12 47.1 0.3 2.0 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ETS62905.1 - 8.8e-08 31.8 0.0 1e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETS62905.1 - 0.0035 17.2 0.0 0.0078 16.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETS62905.1 - 0.0091 15.7 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 ETS62905.1 - 0.096 12.7 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) BUD22 PF09073.10 ETS62905.1 - 0.37 10.1 8.2 0.55 9.5 8.2 1.2 1 0 0 1 1 1 0 BUD22 UCR_TM PF02921.14 ETS62906.1 - 0.086 13.3 0.5 1.4 9.4 0.0 3.1 3 0 0 3 3 3 0 Ubiquinol cytochrome reductase transmembrane region Ysc84 PF04366.12 ETS62907.1 - 9.9e-39 132.0 0.5 9.9e-39 132.0 0.5 1.6 2 0 0 2 2 2 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ETS62907.1 - 2.5e-12 46.2 0.1 5e-12 45.2 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETS62907.1 - 3.4e-10 39.5 0.0 6.5e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ETS62907.1 - 2e-09 37.2 0.0 3.7e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Rad60-SLD PF11976.8 ETS62908.1 - 0.12 12.2 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like UvrD-helicase PF00580.21 ETS62909.1 - 6.4e-69 232.9 0.0 1.5e-68 231.7 0.0 1.6 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ETS62909.1 - 3.7e-57 194.3 0.0 4.7e-30 105.1 0.0 2.7 2 1 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ETS62909.1 - 3.3e-29 102.1 0.0 6.7e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ETS62909.1 - 7e-12 45.0 0.0 1.6e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ETS62909.1 - 4.3e-06 26.6 0.3 0.04 13.6 0.7 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ETS62909.1 - 0.1 12.9 0.1 8.5 6.7 0.1 2.6 2 0 0 2 2 2 0 AAA domain PALP PF00291.25 ETS62910.1 - 4.7e-52 177.2 4.7 6e-52 176.9 4.7 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme GTP_EFTU PF00009.27 ETS62911.1 - 2.9e-52 177.1 0.0 4.8e-52 176.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 ETS62911.1 - 9.2e-22 76.9 0.0 2.2e-21 75.7 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ETS62911.1 - 9.7e-16 57.6 0.2 1.6e-08 34.5 0.0 2.4 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETS62911.1 - 1.5e-08 34.9 0.0 5e-08 33.2 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ETS62911.1 - 9.4e-05 22.2 0.0 0.00019 21.3 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ETS62911.1 - 0.0029 17.7 0.0 0.0074 16.4 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.5 ETS62911.1 - 0.015 15.7 0.0 1.4 9.5 0.0 2.9 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain EFG_IV PF03764.18 ETS62911.1 - 0.04 13.7 0.1 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 Elongation factor G, domain IV cobW PF02492.19 ETS62911.1 - 0.084 12.5 0.1 1.5 8.3 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain HCO3_cotransp PF00955.21 ETS62912.1 - 9.5e-58 196.3 9.1 5.5e-28 98.1 1.1 3.1 1 1 1 2 2 2 2 HCO3- transporter family FHA PF00498.26 ETS62913.1 - 0.029 14.7 0.0 0.076 13.4 0.0 1.7 1 0 0 1 1 1 0 FHA domain DUF3095 PF11294.8 ETS62913.1 - 0.068 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3095) NOA36 PF06524.12 ETS62913.1 - 2.5 7.3 6.8 4.5 6.5 6.8 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETS62913.1 - 7 4.6 13.3 11 4.0 13.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi 4HBT_2 PF13279.6 ETS62914.1 - 0.11 13.0 0.0 0.31 11.5 0.0 1.7 2 0 0 2 2 2 0 Thioesterase-like superfamily TMEM247 PF15444.6 ETS62914.1 - 0.19 11.7 1.3 0.46 10.5 1.3 1.6 1 0 0 1 1 1 0 Transmembrane protein 247 AMP-binding PF00501.28 ETS62915.1 - 4.5e-71 239.7 0.0 6.1e-71 239.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ETS62915.1 - 1.7e-65 220.7 0.0 2.8e-65 220.1 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 ETS62915.1 - 5.9e-13 49.0 0.0 1.7e-12 47.5 0.0 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site Condensation PF00668.20 ETS62915.1 - 5.7e-12 45.1 0.1 1.9e-06 26.8 0.1 3.8 2 1 0 2 2 2 2 Condensation domain AMP-binding_C PF13193.6 ETS62915.1 - 9.2e-05 23.4 0.3 0.0025 18.7 0.3 3.1 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain Epimerase PF01370.21 ETS62915.1 - 0.002 17.7 0.1 0.0049 16.3 0.1 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS62915.1 - 0.0028 16.7 0.0 0.059 12.4 0.0 2.2 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1688 PF07958.11 ETS62917.1 - 4.2e-169 562.7 0.0 5.5e-169 562.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) ABC2_membrane PF01061.24 ETS62918.1 - 2.1e-35 122.0 16.3 2.1e-35 122.0 16.3 2.3 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 ETS62918.1 - 1.1e-24 87.5 0.0 1.8e-24 86.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ETS62918.1 - 0.00021 20.5 19.2 0.00021 20.5 19.2 1.8 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 ETS62918.1 - 0.00069 19.5 0.0 0.024 14.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETS62918.1 - 0.0098 15.6 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.6 ETS62918.1 - 0.029 14.6 0.0 0.054 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETS62918.1 - 0.051 13.5 0.0 0.12 12.3 0.0 1.5 2 0 0 2 2 1 0 RsgA GTPase AAA_25 PF13481.6 ETS62918.1 - 0.061 12.9 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETS62918.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ETS62918.1 - 0.18 12.1 0.0 0.37 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETS62918.1 - 0.18 11.7 0.1 0.33 10.8 0.1 1.4 1 0 0 1 1 1 0 NACHT domain SMC_N PF02463.19 ETS62918.1 - 0.2 11.1 0.0 0.59 9.5 0.0 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETS62918.1 - 0.24 11.9 0.0 0.41 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RskA PF10099.9 ETS62918.1 - 2.4 8.4 4.3 21 5.4 1.9 2.3 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF3357 PF11837.8 ETS62918.1 - 3.2 8.3 5.6 9 6.8 0.1 3.0 3 0 0 3 3 2 0 Domain of unknown function (DUF3357) LRR_4 PF12799.7 ETS62920.1 - 2.5e-23 81.8 12.0 0.0006 20.2 0.1 9.1 7 3 3 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETS62920.1 - 1.5e-21 75.9 16.8 4.9e-08 32.6 0.5 6.1 5 1 1 6 6 6 4 Leucine rich repeat Hemerythrin PF01814.23 ETS62920.1 - 4.9e-10 40.1 1.6 4.9e-10 40.1 1.6 3.4 2 1 1 3 3 3 2 Hemerythrin HHE cation binding domain LRR_9 PF14580.6 ETS62920.1 - 8.4e-09 35.2 3.1 0.0056 16.2 0.1 3.6 2 1 0 3 3 3 3 Leucine-rich repeat LRR_6 PF13516.6 ETS62920.1 - 1.1 9.5 16.7 0.46 10.7 0.2 6.1 6 1 1 7 7 7 0 Leucine Rich repeat MAP65_ASE1 PF03999.12 ETS62921.1 - 4.6e-64 217.2 0.0 4.9e-57 194.0 0.0 2.2 2 0 0 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) DUF1192 PF06698.11 ETS62921.1 - 0.11 12.6 2.9 2.3 8.4 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Baculo_PEP_C PF04513.12 ETS62921.1 - 0.49 10.4 3.4 0.47 10.5 0.2 2.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus HrpB7 PF09486.10 ETS62921.1 - 5 7.5 13.1 11 6.4 0.2 4.1 4 1 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) PGP_phosphatase PF09419.10 ETS62922.1 - 8.4e-49 165.4 0.0 1.4e-44 151.7 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 ETS62922.1 - 0.053 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 HAD-hyrolase-like PLDc_3 PF13918.6 ETS62925.1 - 0.033 13.9 0.0 0.045 13.4 0.0 1.1 1 0 0 1 1 1 0 PLD-like domain Lum_binding PF00677.17 ETS62926.1 - 2.8e-38 129.8 0.1 4.7e-19 68.2 0.1 2.3 2 0 0 2 2 2 2 Lumazine binding domain Homoserine_dh PF00742.19 ETS62927.1 - 1.6e-48 164.9 0.0 2.2e-48 164.5 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 ETS62927.1 - 5.8e-15 56.0 0.0 1e-14 55.2 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain BUD22 PF09073.10 ETS62928.1 - 1.1e-98 331.5 39.6 1.1e-98 331.5 39.6 2.3 2 0 0 2 2 2 1 BUD22 PP1_inhibitor PF05361.12 ETS62928.1 - 5 7.1 8.3 0.1 12.6 0.5 2.2 2 0 0 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor AF-4 PF05110.13 ETS62928.1 - 8.4 4.3 55.0 0.61 8.1 34.4 2.4 2 0 0 2 2 2 0 AF-4 proto-oncoprotein GMC_oxred_N PF00732.19 ETS62929.1 - 6.4e-58 196.5 0.0 9.5e-58 195.9 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS62929.1 - 2.1e-34 119.1 0.2 4.3e-34 118.1 0.2 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Peptidase_M20 PF01546.28 ETS62929.1 - 1.7e-30 106.3 0.0 3.3e-30 105.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETS62929.1 - 0.00011 22.0 0.0 0.00048 20.0 0.0 2.1 2 0 0 2 2 2 1 Peptidase dimerisation domain Lycopene_cycl PF05834.12 ETS62929.1 - 0.00065 18.9 0.8 0.001 18.2 0.2 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein Peptidase_M28 PF04389.17 ETS62929.1 - 0.0017 18.0 0.0 0.0041 16.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M28 NAD_binding_8 PF13450.6 ETS62929.1 - 0.0023 18.1 0.6 0.0076 16.5 0.6 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETS62929.1 - 0.0024 17.2 0.1 0.0055 16.0 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ETS62929.1 - 0.013 14.8 0.1 0.03 13.6 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS62929.1 - 0.013 15.1 1.8 0.017 14.7 0.5 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS62929.1 - 0.21 10.8 0.6 0.82 8.9 0.2 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS62929.1 - 0.46 9.5 4.4 0.92 8.5 4.4 1.5 1 0 0 1 1 1 0 FAD binding domain DLH PF01738.18 ETS62930.1 - 3.7e-20 72.4 0.3 4.3e-20 72.2 0.3 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Saf_2TM PF18303.1 ETS62931.1 - 0.23 11.1 0.0 0.37 10.4 0.0 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain PspB PF06667.12 ETS62931.1 - 0.24 11.5 0.0 0.46 10.6 0.0 1.4 1 0 0 1 1 1 0 Phage shock protein B FMO-like PF00743.19 ETS62932.1 - 2.5e-17 62.5 0.0 3.1e-15 55.6 0.1 2.7 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETS62932.1 - 3.4e-11 42.9 0.0 3.8e-08 32.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS62932.1 - 4.7e-11 42.5 0.1 1.2e-10 41.2 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS62932.1 - 1.8e-08 34.5 0.0 1e-06 28.8 0.0 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ETS62932.1 - 2e-06 27.2 0.1 2.3e-05 23.7 0.0 2.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 ETS62932.1 - 1.4e-05 24.9 0.3 0.23 11.0 0.0 3.5 2 1 2 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.17 ETS62932.1 - 2.2e-05 23.8 0.0 6.3e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 ETS62932.1 - 2.7e-05 24.6 0.1 0.0068 16.9 0.0 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 ETS62932.1 - 0.011 14.3 0.1 0.063 11.8 0.1 1.9 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) FAD_binding_2 PF00890.24 ETS62932.1 - 0.031 13.3 0.0 0.17 10.9 0.0 2.2 3 0 0 3 3 3 0 FAD binding domain GST_C_5 PF16865.5 ETS62932.1 - 0.035 14.7 0.1 0.095 13.3 0.1 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain FAD_oxidored PF12831.7 ETS62932.1 - 0.041 13.2 0.0 3.2 7.0 0.0 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ETS62932.1 - 0.099 11.7 0.1 21 4.0 0.0 3.0 3 1 0 3 3 3 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 ETS62932.1 - 0.16 12.4 0.0 0.36 11.3 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Amidohydro_1 PF01979.20 ETS62933.1 - 2.2e-16 60.1 0.0 1.3e-14 54.3 0.0 2.5 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ETS62933.1 - 4.8e-12 46.1 0.3 2.6e-08 33.8 0.1 2.3 2 0 0 2 2 2 2 Amidohydrolase family DUF3605 PF12239.8 ETS62934.1 - 1.6e-30 106.5 0.0 1.5e-20 74.1 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3605) BcrAD_BadFG PF01869.20 ETS62936.1 - 2.1e-09 37.3 0.0 1.5e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 BadF/BadG/BcrA/BcrD ATPase family Glucosamine_iso PF01182.20 ETS62937.1 - 1.4e-21 77.5 0.0 2.2e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Zn_clus PF00172.18 ETS62938.1 - 1.6e-06 28.1 9.0 1.6e-06 28.1 9.0 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PGM_PMM_I PF02878.16 ETS62939.1 - 5.6e-35 120.0 0.0 1e-34 119.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ETS62939.1 - 1.2e-15 57.9 0.0 3.5e-15 56.5 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ETS62939.1 - 1.5e-12 47.7 0.0 3.1e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 ETS62939.1 - 1.4e-08 34.7 0.0 4.2e-08 33.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Lipase_3 PF01764.25 ETS62940.1 - 1e-11 44.9 0.0 1e-11 44.9 0.0 1.7 2 0 0 2 2 2 1 Lipase (class 3) OprF PF05736.11 ETS62940.1 - 0.098 12.4 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 OprF membrane domain ATP-synt_E PF05680.12 ETS62940.1 - 0.18 12.2 0.8 1 9.7 0.0 2.5 2 0 0 2 2 2 0 ATP synthase E chain DUF1479 PF07350.12 ETS62941.1 - 1.1e-144 482.3 0.0 1.3e-144 482.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) PhyH PF05721.13 ETS62941.1 - 0.0043 17.3 0.3 4.4 7.5 0.0 2.9 3 0 0 3 3 3 2 Phytanoyl-CoA dioxygenase (PhyH) TauD PF02668.16 ETS62941.1 - 0.12 12.1 0.3 2.7 7.7 0.0 2.3 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family p450 PF00067.22 ETS62942.1 - 5.3e-53 180.4 0.0 7e-53 180.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 APS_kinase PF01583.20 ETS62945.1 - 1.1e-69 233.4 0.0 1.3e-69 233.1 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 ETS62945.1 - 1.7e-06 28.2 0.0 2.9e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETS62945.1 - 7.8e-05 23.2 0.0 0.00011 22.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ETS62945.1 - 0.00028 20.4 0.0 0.00033 20.2 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_29 PF13555.6 ETS62945.1 - 0.0053 16.5 0.0 0.0091 15.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 ETS62945.1 - 0.012 15.0 0.0 0.03 13.6 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin AAA_16 PF13191.6 ETS62945.1 - 0.034 14.5 0.1 0.045 14.1 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETS62945.1 - 0.039 14.5 0.0 0.067 13.7 0.0 1.4 1 1 0 1 1 1 0 ABC transporter DUF463 PF04317.12 ETS62945.1 - 0.056 12.4 0.1 0.082 11.8 0.1 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 PRK PF00485.18 ETS62945.1 - 0.078 12.7 0.0 0.17 11.6 0.0 1.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family GlcNAc-1_reg PF18440.1 ETS62945.1 - 0.093 13.0 0.0 0.64 10.3 0.0 2.1 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain TctC PF03401.14 ETS62945.1 - 0.16 11.0 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor CPT PF07931.12 ETS62945.1 - 0.19 11.6 0.1 0.41 10.5 0.1 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein MaoC_dehydrat_N PF13452.6 ETS62946.1 - 1.7e-08 34.7 0.0 7.6e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 ETS62946.1 - 9.7e-05 21.9 0.0 0.00023 20.7 0.0 1.6 2 0 0 2 2 2 1 MaoC like domain SelR PF01641.18 ETS62947.1 - 2.9e-50 169.4 0.2 3.7e-50 169.0 0.2 1.1 1 0 0 1 1 1 1 SelR domain WD40 PF00400.32 ETS62948.1 - 9.9e-12 45.2 13.5 0.0016 19.3 0.0 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS62948.1 - 7e-06 26.3 0.0 1.9 8.9 0.0 5.0 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETS62949.1 - 0.23 12.4 10.6 13 6.8 0.1 4.8 4 0 0 4 4 4 0 WD domain, G-beta repeat MBOAT_2 PF13813.6 ETS62950.1 - 6.8e-09 35.9 0.7 4.4e-07 30.1 0.7 2.6 1 1 0 1 1 1 1 Membrane bound O-acyl transferase family DEAD PF00270.29 ETS62951.1 - 1e-48 165.4 0.0 1.8e-48 164.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS62951.1 - 3e-33 114.5 0.0 1e-29 103.1 0.1 2.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ETS62951.1 - 2e-05 24.7 2.1 6.1e-05 23.1 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ETS62951.1 - 0.0013 18.1 0.0 0.0013 18.1 0.0 3.3 2 1 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ERCC3_RAD25_C PF16203.5 ETS62951.1 - 0.0084 15.3 0.0 0.0084 15.3 0.0 2.4 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase Zip PF02535.22 ETS62951.1 - 0.25 10.5 0.9 0.29 10.3 0.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIF_alpha PF05793.12 ETS62951.1 - 0.54 8.8 21.9 0.77 8.3 21.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sporozoite_P67 PF05642.11 ETS62951.1 - 1.9 6.5 9.7 2.5 6.1 9.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ndc1_Nup PF09531.10 ETS62951.1 - 4.3 5.9 6.3 5.9 5.4 6.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 ETS62951.1 - 8.9 4.5 17.8 13 3.9 17.8 1.1 1 0 0 1 1 1 0 CDC45-like protein adh_short PF00106.25 ETS62952.1 - 4.6e-20 71.9 0.0 9e-13 48.1 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS62952.1 - 6.3e-15 55.4 0.0 4.3e-13 49.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS62952.1 - 0.0001 22.2 0.1 0.00032 20.7 0.0 1.7 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 ETS62952.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding EF-hand_5 PF13202.6 ETS62953.1 - 0.042 13.4 0.3 0.12 11.9 0.0 1.8 2 0 0 2 2 2 0 EF hand Ras PF00071.22 ETS62954.1 - 2e-52 177.1 0.0 2.4e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS62954.1 - 1.8e-32 112.0 0.0 2.5e-32 111.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS62954.1 - 3.5e-11 42.9 0.0 4.7e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS62954.1 - 1.4e-05 24.7 0.0 0.00067 19.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETS62954.1 - 0.00012 21.5 0.0 0.00015 21.2 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS62954.1 - 0.00024 21.2 0.0 0.00036 20.6 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ETS62954.1 - 0.0029 17.2 0.0 0.0043 16.6 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region DAP3 PF10236.9 ETS62954.1 - 0.0095 15.1 0.0 0.016 14.4 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 SRPRB PF09439.10 ETS62954.1 - 0.011 15.1 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 ETS62954.1 - 0.018 15.0 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 ETS62954.1 - 0.019 14.3 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 KaiC AAA_16 PF13191.6 ETS62954.1 - 0.023 15.1 0.0 0.048 14.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 ETS62954.1 - 0.025 14.3 0.0 0.056 13.1 0.0 1.5 2 0 0 2 2 2 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 ETS62954.1 - 0.026 14.4 0.0 2.6 7.9 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 ETS62954.1 - 0.032 14.5 0.0 0.045 14.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain TetR_C_16 PF17920.1 ETS62954.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF2075 PF09848.9 ETS62954.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Septin PF00735.18 ETS62954.1 - 0.23 10.7 0.0 0.3 10.3 0.0 1.1 1 0 0 1 1 1 0 Septin RWD PF05773.22 ETS62955.1 - 9.8e-18 64.5 1.1 1.5e-17 63.9 0.1 1.9 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.5 ETS62955.1 - 2.3e-05 24.8 13.6 2.3e-05 24.8 13.6 2.8 1 1 1 2 2 2 1 DRG Family Regulatory Proteins, Tma46 TrbC_Ftype PF09673.10 ETS62955.1 - 0.062 13.3 0.2 0.11 12.5 0.2 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein PRP1_N PF06424.12 ETS62955.1 - 1 9.7 19.5 2.4 8.6 19.3 1.7 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal HlyIII PF03006.20 ETS62956.1 - 4e-56 190.2 21.0 4e-56 190.2 21.0 2.6 2 1 0 2 2 2 1 Haemolysin-III related PLAC9 PF15205.6 ETS62957.1 - 0.97 9.9 3.4 1 9.8 0.1 2.6 3 0 0 3 3 3 0 Placenta-specific protein 9 Use1 PF09753.9 ETS62958.1 - 10 5.8 9.0 20 4.8 9.0 1.6 1 1 0 1 1 1 0 Membrane fusion protein Use1 PhoPQ_related PF10142.9 ETS62960.1 - 0.093 11.4 0.0 0.15 10.7 0.0 1.3 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Cyt-b5 PF00173.28 ETS62961.1 - 1.7e-22 79.3 0.2 1.9e-22 79.2 0.2 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rit1_C PF17184.4 ETS62962.1 - 1.6e-77 260.6 0.2 4.1e-45 154.3 0.0 2.1 1 1 1 2 2 2 2 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 ETS62962.1 - 7.1e-24 84.2 0.0 1.7e-23 83.0 0.0 1.7 1 0 0 1 1 1 1 Rit1 DUSP-like domain DUF4633 PF15464.6 ETS62962.1 - 0.054 13.7 0.0 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) HORMA PF02301.18 ETS62963.1 - 0.025 14.2 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 HORMA domain zf-CCCH PF00642.24 ETS62964.1 - 0.012 15.5 9.8 0.24 11.4 1.4 2.5 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS62964.1 - 0.014 15.4 5.9 1 9.5 1.2 2.6 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_4 PF18044.1 ETS62964.1 - 0.024 14.4 5.8 0.68 9.8 0.7 2.6 2 0 0 2 2 2 0 CCCH-type zinc finger Torus PF16131.5 ETS62964.1 - 0.44 11.3 4.1 0.25 12.1 0.4 2.2 1 1 1 2 2 2 0 Torus domain zf-CCCH_2 PF14608.6 ETS62964.1 - 0.73 10.4 6.4 8.9 6.9 0.1 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger E1-E2_ATPase PF00122.20 ETS62965.1 - 1.2e-38 132.5 16.4 7.9e-32 110.2 0.8 2.8 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETS62965.1 - 1.4e-29 103.1 3.4 1.4e-29 103.1 3.4 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETS62965.1 - 1.1e-21 78.1 0.4 1.3e-19 71.3 0.4 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS62965.1 - 7.4e-19 67.6 0.1 1.4e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ETS62965.1 - 2.2e-12 46.5 0.0 4.9e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ETS62965.1 - 0.00026 20.8 0.8 0.0042 16.8 1.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DctM PF06808.12 ETS62965.1 - 0.0021 17.0 0.1 0.0021 17.0 0.1 2.1 3 0 0 3 3 3 1 Tripartite ATP-independent periplasmic transporter, DctM component ABC_tran PF00005.27 ETS62966.1 - 1.1e-49 168.5 0.0 5.5e-30 104.7 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ETS62966.1 - 2.4e-26 93.0 32.4 2.9e-15 56.7 8.0 2.8 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 ETS62966.1 - 8.8e-07 28.6 4.1 0.031 13.7 0.1 4.0 3 1 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ETS62966.1 - 8.2e-06 26.1 0.4 0.13 12.5 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ETS62966.1 - 1.4e-05 24.8 0.1 0.0042 16.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ETS62966.1 - 5.8e-05 22.8 0.7 0.034 13.9 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ETS62966.1 - 0.0001 22.8 1.3 0.13 12.7 0.1 3.2 3 0 0 3 3 2 2 AAA ATPase domain AAA_21 PF13304.6 ETS62966.1 - 0.00019 21.4 0.1 0.71 9.6 0.0 3.4 3 1 1 4 4 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ETS62966.1 - 0.00036 20.5 1.5 0.099 12.5 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ETS62966.1 - 0.0069 16.5 0.0 7 6.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase CbiA PF01656.23 ETS62966.1 - 0.0073 16.4 0.1 0.53 10.4 0.0 2.5 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_23 PF13476.6 ETS62966.1 - 0.019 15.5 0.0 1.7 9.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ETS62966.1 - 0.02 14.8 2.7 0.59 10.0 0.3 3.2 4 0 0 4 4 3 0 NACHT domain cobW PF02492.19 ETS62966.1 - 0.027 14.1 2.3 1.6 8.3 0.6 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 ETS62966.1 - 0.032 14.0 1.8 7.8 6.2 0.1 3.1 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETS62966.1 - 0.036 13.6 0.2 3.1 7.3 0.1 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region MobB PF03205.14 ETS62966.1 - 0.054 13.4 0.5 4.1 7.3 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Dynamin_N PF00350.23 ETS62966.1 - 0.1 12.6 0.1 12 5.9 0.0 2.5 2 0 0 2 2 2 0 Dynamin family Pox_A32 PF04665.12 ETS62966.1 - 0.14 11.6 1.5 0.85 9.0 0.0 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein Methyltr_RsmB-F PF01189.17 ETS62966.1 - 0.14 11.8 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F AAA_33 PF13671.6 ETS62966.1 - 0.15 12.2 0.1 4.5 7.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain MaoC_dehydratas PF01575.19 ETS62967.1 - 6.8e-27 93.5 0.0 2.5e-26 91.6 0.0 2.0 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ETS62967.1 - 6.5e-09 36.0 0.0 4.1e-07 30.2 0.0 2.4 2 1 0 2 2 2 2 N-terminal half of MaoC dehydratase BAR PF03114.18 ETS62968.1 - 2.1e-43 148.7 6.8 2.9e-43 148.2 6.8 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ETS62968.1 - 6.6e-15 54.5 0.1 1.3e-14 53.5 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS62968.1 - 8.3e-14 51.2 0.1 1.7e-13 50.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETS62968.1 - 1.3e-10 40.8 0.0 2.3e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 ETS62968.1 - 0.023 14.4 0.1 0.049 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) Prefoldin PF02996.17 ETS62968.1 - 0.084 12.8 1.4 0.16 11.9 0.1 2.0 2 0 0 2 2 2 0 Prefoldin subunit Vac_Fusion PF02346.16 ETS62968.1 - 0.21 11.2 1.3 50 3.6 0.0 3.8 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 COX16 PF14138.6 ETS62968.1 - 3.2 8.3 5.2 39 4.9 2.9 2.4 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 Cwf_Cwc_15 PF04889.12 ETS62969.1 - 0.013 15.2 2.8 0.027 14.2 2.8 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 ETS62969.1 - 0.21 11.9 3.6 0.45 10.9 2.2 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pox_Ag35 PF03286.14 ETS62969.1 - 0.36 10.6 3.4 0.74 9.6 3.4 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETS62969.1 - 0.67 9.2 2.1 1.2 8.4 2.1 1.3 1 0 0 1 1 1 0 NOA36 protein Glyco_hydro_43 PF04616.14 ETS62970.1 - 2.8e-16 59.7 0.3 4.2e-16 59.1 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF1295 PF06966.12 ETS62971.1 - 4.8e-52 176.8 0.4 6.5e-52 176.4 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ETS62971.1 - 0.0011 19.3 0.1 0.0047 17.3 0.0 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase Steroid_dh PF02544.16 ETS62971.1 - 0.0025 17.8 2.4 0.0033 17.4 0.0 2.1 2 1 1 3 3 3 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 ETS62971.1 - 0.019 15.4 0.0 0.041 14.3 0.0 1.6 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Methyltransf_16 PF10294.9 ETS62972.1 - 2.2e-14 53.6 0.0 2.2e-09 37.3 0.0 2.3 2 0 0 2 2 2 2 Lysine methyltransferase Metallopep PF12044.8 ETS62973.1 - 9.8e-94 314.4 0.0 1.1e-73 248.3 0.0 2.0 2 0 0 2 2 2 2 Putative peptidase family Peptidase_M66 PF10462.9 ETS62973.1 - 0.045 12.7 0.2 0.082 11.8 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 Jacalin PF01419.17 ETS62973.1 - 0.054 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Jacalin-like lectin domain Aldo_ket_red PF00248.21 ETS62974.1 - 1.4e-49 168.9 0.1 4.4e-48 164.0 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Phage_X PF05155.15 ETS62974.1 - 0.075 13.4 0.0 0.66 10.4 0.0 2.5 3 0 0 3 3 3 0 Phage X family DUF2256 PF10013.9 ETS62975.1 - 2.6e-15 56.2 3.0 4.9e-15 55.4 3.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2256) zf-RING_12 PF17976.1 ETS62975.1 - 0.11 12.7 0.2 0.24 11.7 0.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Aldose_epim PF01263.20 ETS62976.1 - 5.1e-29 101.5 0.0 7.7e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase YjbT PF17089.5 ETS62977.1 - 0.1 12.6 0.3 0.27 11.3 0.3 1.6 1 0 0 1 1 1 0 Uncharacterised protein family Xan_ur_permease PF00860.20 ETS62978.1 - 2.3e-25 89.1 29.7 2.5e-25 89.0 26.1 2.3 2 1 0 2 2 2 1 Permease family ABC_tran PF00005.27 ETS62980.1 - 2e-50 170.9 1.0 3.3e-28 98.9 0.2 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 ETS62980.1 - 4.4e-31 108.5 21.6 3.7e-22 79.3 6.7 2.7 2 0 0 2 2 2 2 ABC transporter transmembrane region SMC_N PF02463.19 ETS62980.1 - 1.3e-09 37.8 6.3 0.0021 17.5 2.3 3.5 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS62980.1 - 1.6e-06 27.7 0.4 0.024 14.3 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETS62980.1 - 9.3e-06 25.6 0.6 0.078 12.9 0.2 2.7 2 1 0 2 2 2 2 RsgA GTPase AAA_21 PF13304.6 ETS62980.1 - 1.2e-05 25.3 0.8 1.3 8.8 0.0 4.2 2 2 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ETS62980.1 - 4e-05 23.9 0.6 0.57 10.5 0.4 3.3 2 1 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ETS62980.1 - 0.0013 18.8 0.0 2.6 8.2 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_30 PF13604.6 ETS62980.1 - 0.0014 18.3 0.4 0.021 14.6 0.1 2.7 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ETS62980.1 - 0.0015 17.9 0.0 0.88 8.9 0.0 2.6 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_16 PF13191.6 ETS62980.1 - 0.0082 16.5 2.1 0.43 11.0 0.2 3.0 3 1 0 3 3 2 1 AAA ATPase domain AAA_23 PF13476.6 ETS62980.1 - 0.0086 16.6 0.0 0.62 10.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ETS62980.1 - 0.022 14.3 1.1 3.8 7.0 0.0 3.1 3 0 0 3 3 3 0 AAA domain NB-ARC PF00931.22 ETS62980.1 - 0.029 13.6 0.2 2.9 7.0 0.2 2.8 2 1 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 ETS62980.1 - 0.059 13.1 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ETS62980.1 - 0.06 13.5 0.0 11 6.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ETS62980.1 - 0.071 12.8 0.0 8.9 5.9 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Pox_A32 PF04665.12 ETS62980.1 - 0.088 12.3 0.3 0.2 11.1 0.3 1.5 1 0 0 1 1 1 0 Poxvirus A32 protein cobW PF02492.19 ETS62980.1 - 0.1 12.2 0.1 1.9 8.1 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Septin PF00735.18 ETS62980.1 - 0.13 11.5 0.0 7.9 5.7 0.0 2.3 2 0 0 2 2 2 0 Septin Dynamin_N PF00350.23 ETS62980.1 - 0.13 12.3 0.2 0.8 9.7 0.0 2.1 2 0 0 2 2 2 0 Dynamin family ABC_ATPase PF09818.9 ETS62980.1 - 0.36 9.6 4.3 0.51 9.1 0.0 2.7 3 0 0 3 3 3 0 Predicted ATPase of the ABC class MARVEL PF01284.23 ETS62981.1 - 1.8e-08 34.5 6.8 2.7e-08 33.9 6.8 1.3 1 0 0 1 1 1 1 Membrane-associating domain MSP1a PF11670.8 ETS62981.1 - 0.12 11.6 0.4 0.19 11.0 0.4 1.3 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) DUF1206 PF06724.11 ETS62981.1 - 0.42 10.7 5.3 0.37 10.9 0.8 2.5 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1206) DUF2627 PF11118.8 ETS62981.1 - 7.4 7.2 8.8 1.8 9.2 0.7 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2627) Cmc1 PF08583.10 ETS62982.1 - 1.9e-13 50.2 0.8 2.2e-13 50.0 0.8 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NDUF_B7 PF05676.13 ETS62982.1 - 0.00029 20.5 0.5 0.00039 20.1 0.5 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) DUF3128 PF11326.8 ETS62982.1 - 0.21 12.0 3.6 0.46 10.9 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) UCR_hinge PF02320.16 ETS62982.1 - 0.33 11.2 4.9 9.7 6.5 0.4 2.3 1 1 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein YgaB PF14182.6 ETS62982.1 - 0.4 11.1 3.2 3.9 7.9 1.0 2.0 1 1 1 2 2 2 0 YgaB-like protein DUF2237 PF09996.9 ETS62983.1 - 1.8e-38 131.1 0.0 3.4e-38 130.2 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2237) LRR_8 PF13855.6 ETS62983.1 - 9.7e-13 47.7 16.2 9.2e-09 34.9 6.0 4.4 3 1 2 5 5 5 3 Leucine rich repeat LRR_9 PF14580.6 ETS62983.1 - 3.4e-09 36.4 0.6 0.00012 21.7 0.4 2.5 2 0 0 2 2 2 2 Leucine-rich repeat LRR_4 PF12799.7 ETS62983.1 - 7.5e-07 29.4 30.6 1.8e-05 25.0 1.7 5.7 4 2 3 7 7 7 3 Leucine Rich repeats (2 copies) AA_permease_2 PF13520.6 ETS62984.1 - 3.9e-58 197.3 36.9 4.9e-58 197.0 36.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS62984.1 - 5.9e-25 87.8 32.5 7.4e-25 87.5 32.5 1.1 1 0 0 1 1 1 1 Amino acid permease FDF PF09532.10 ETS62985.1 - 4.4e-05 24.3 0.4 0.00025 21.9 0.0 2.3 2 0 0 2 2 2 1 FDF domain Thioredoxin_12 PF18400.1 ETS62985.1 - 0.02 14.7 0.7 0.12 12.2 0.1 2.5 2 1 1 3 3 3 0 Thioredoxin-like domain DUF2059 PF09832.9 ETS62985.1 - 0.11 12.5 0.4 0.5 10.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2059) Macoilin PF09726.9 ETS62985.1 - 0.6 8.6 8.8 0.0076 14.9 1.3 1.6 2 0 0 2 2 2 0 Macoilin family HalX PF08663.10 ETS62985.1 - 0.67 10.3 4.8 13 6.2 0.2 2.9 2 0 0 2 2 2 0 HalX domain NUDIX PF00293.28 ETS62986.1 - 1.2e-09 38.3 0.0 2.3e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DnaJ_C PF01556.18 ETS62987.1 - 4.2e-36 124.2 0.2 6.1e-36 123.7 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ETS62987.1 - 2.6e-23 81.9 1.4 5.4e-23 80.9 1.4 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ETS62987.1 - 4.7e-14 52.5 19.1 7.7e-14 51.8 19.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Cytochrom_c3_2 PF14537.6 ETS62987.1 - 0.067 13.7 11.8 0.52 10.8 5.2 2.3 1 1 1 2 2 2 0 Cytochrome c3 Anti-TRAP PF15777.5 ETS62987.1 - 0.15 12.1 17.4 0.046 13.7 4.5 2.7 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cytochrome_C7 PF14522.6 ETS62987.1 - 0.75 9.8 12.1 9.5 6.3 12.8 2.1 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c DZR PF12773.7 ETS62987.1 - 7.4 6.7 8.5 12 6.0 1.6 2.3 2 0 0 2 2 2 0 Double zinc ribbon HypA PF01155.19 ETS62987.1 - 8.8 6.4 14.2 1.6 8.8 4.4 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DcpS_C PF11969.8 ETS62988.1 - 5.2e-27 94.6 0.3 9.3e-27 93.8 0.3 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 ETS62988.1 - 1.9e-25 89.7 0.0 5.3e-25 88.3 0.0 1.7 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal HIT PF01230.23 ETS62988.1 - 0.016 15.9 0.2 0.044 14.5 0.2 1.8 1 0 0 1 1 1 0 HIT domain UPF0240 PF06784.11 ETS62989.1 - 0.02 14.9 7.3 0.08 13.0 4.7 2.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0240) Lge1 PF11488.8 ETS62989.1 - 0.059 13.6 1.2 0.91 9.8 0.1 2.5 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 S36_mt PF10937.8 ETS62989.1 - 5.6 8.6 9.0 8.7 8.0 8.1 1.8 1 1 1 2 2 2 0 Ribosomal protein S36, mitochondrial Glyco_hydro_85 PF03644.13 ETS62990.1 - 3e-87 292.8 0.0 4.8e-87 292.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 85 IU_nuc_hydro PF01156.19 ETS62991.1 - 6.5e-58 196.7 0.0 1.5e-57 195.5 0.0 1.5 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Mito_carr PF00153.27 ETS62991.1 - 6.8e-47 157.4 3.8 8.9e-16 57.6 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein Transthyretin PF00576.21 ETS62992.1 - 1.1e-37 129.1 0.0 1.2e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family Big_1 PF02369.16 ETS62992.1 - 0.2 11.7 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) PQ-loop PF04193.14 ETS62994.1 - 3e-24 84.6 1.2 6.6e-12 45.0 0.6 2.4 2 0 0 2 2 2 2 PQ loop repeat SNase PF00565.17 ETS62995.1 - 1e-20 74.2 1.2 5.5e-09 36.5 0.8 3.3 1 1 1 2 2 2 2 Staphylococcal nuclease homologue GFO_IDH_MocA PF01408.22 ETS62996.1 - 1.7e-14 54.6 0.0 3e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ETS62996.1 - 1.1e-11 44.7 0.0 2e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Glyco_hydro_92 PF07971.12 ETS62997.1 - 7e-145 483.5 0.0 8.7e-145 483.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 ETS62997.1 - 4.9e-41 141.2 0.7 1.1e-40 140.1 0.7 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DUF1275 PF06912.11 ETS62998.1 - 1.1e-21 77.6 14.3 1.1e-21 77.6 14.3 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1275) TMEM65 PF10507.9 ETS62998.1 - 0.0072 16.3 1.1 0.071 13.1 0.1 2.5 2 1 1 3 3 3 1 Transmembrane protein 65 CarS-like PF01864.17 ETS62998.1 - 0.04 13.9 0.6 0.073 13.1 0.2 1.6 2 0 0 2 2 2 0 CDP-archaeol synthase Asp-Al_Ex PF06826.12 ETS62998.1 - 0.44 10.4 9.3 0.16 11.8 0.2 3.0 3 0 0 3 3 3 0 Predicted Permease Membrane Region DUF2721 PF11026.8 ETS62998.1 - 7.8 6.4 11.6 9.3 6.2 1.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2721) Aldose_epim PF01263.20 ETS62999.1 - 1.7e-60 204.9 0.2 2e-60 204.6 0.2 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase CoA_binding_2 PF13380.6 ETS63000.1 - 3.7e-26 91.9 0.1 6.2e-26 91.2 0.1 1.4 1 0 0 1 1 1 1 CoA binding domain FAA_hydrolase PF01557.18 ETS63001.1 - 2.1e-56 191.0 0.0 2.5e-56 190.8 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2470 PF10615.9 ETS63002.1 - 6e-19 68.5 0.0 1e-18 67.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 ETS63002.1 - 1.7e-05 25.1 0.7 3.2e-05 24.1 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4499) GSHPx PF00255.19 ETS63003.1 - 4.4e-41 138.8 1.5 5.8e-41 138.4 1.5 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ETS63003.1 - 1.6e-06 28.1 0.3 1.1e-05 25.4 0.3 2.1 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ETS63003.1 - 9.2e-06 25.4 0.1 2e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 Redoxin DUF4174 PF13778.6 ETS63003.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4174) MVP_shoulder PF11978.8 ETS63004.1 - 0.052 13.6 0.1 0.087 12.8 0.1 1.4 1 0 0 1 1 1 0 Shoulder domain HTH_31 PF13560.6 ETS63004.1 - 0.1 13.0 3.6 30 5.1 0.4 3.4 3 1 0 3 3 3 0 Helix-turn-helix domain UL2 PF08196.11 ETS63004.1 - 0.1 12.6 0.1 0.23 11.4 0.1 1.6 1 0 0 1 1 1 0 UL2 protein HTH_3 PF01381.22 ETS63004.1 - 0.8 9.8 2.8 6.5 6.9 0.0 3.3 4 0 0 4 4 4 0 Helix-turn-helix S-methyl_trans PF02574.16 ETS63006.1 - 1.3e-42 146.5 0.0 8e-42 143.9 0.0 1.9 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Polysacc_deac_1 PF01522.21 ETS63008.1 - 6.6e-21 74.5 0.0 1.1e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Bacteriocin_IId PF09221.10 ETS63008.1 - 0.061 13.5 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacteriocin class IId cyclical uberolysin-like Glyco_hydro_57 PF03065.15 ETS63008.1 - 0.063 12.5 0.0 0.089 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Erg28 PF03694.13 ETS63009.1 - 9.9e-39 132.1 1.6 1.3e-38 131.8 1.6 1.1 1 0 0 1 1 1 1 Erg28 like protein PTR2 PF00854.21 ETS63009.1 - 0.032 13.1 1.2 0.041 12.7 0.4 1.5 2 0 0 2 2 2 0 POT family DNA_ligase_OB_2 PF14743.6 ETS63010.1 - 4.7e-24 84.2 0.1 1.1e-23 83.0 0.1 1.7 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_M PF01068.21 ETS63010.1 - 1.4e-08 34.6 0.0 4.2e-06 26.6 0.0 2.3 2 0 0 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ETS63010.1 - 0.036 14.4 0.0 11 6.3 0.0 2.6 2 1 0 2 2 2 0 RNA ligase Aldo_ket_red PF00248.21 ETS63012.1 - 9.4e-66 222.0 0.0 1.2e-65 221.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family A_deaminase PF00962.22 ETS63013.1 - 7.9e-26 91.2 0.0 3.1e-25 89.2 0.0 1.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase Mg_trans_NIPA PF05653.14 ETS63014.1 - 3.4e-91 305.4 29.1 4.5e-91 305.0 29.1 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ETS63014.1 - 5.3e-05 23.4 11.7 5.3e-05 23.4 11.7 3.0 2 1 0 2 2 2 1 EamA-like transporter family WSN PF02206.18 ETS63014.1 - 0.011 15.7 0.3 0.021 14.7 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function Mito_carr PF00153.27 ETS63015.1 - 6.3e-52 173.5 4.9 3.4e-18 65.3 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein START PF01852.19 ETS63016.1 - 6.1e-11 42.1 0.5 9.9e-11 41.4 0.5 1.3 1 0 0 1 1 1 1 START domain MoaE PF02391.17 ETS63017.1 - 4.3e-38 130.1 0.1 6.6e-38 129.5 0.1 1.3 1 0 0 1 1 1 1 MoaE protein Ribonuclease PF00545.20 ETS63017.1 - 2.2e-07 31.5 0.6 4.2e-07 30.6 0.6 1.5 1 0 0 1 1 1 1 ribonuclease ACP_syn_III PF08545.10 ETS63017.1 - 0.11 12.3 0.3 0.51 10.2 0.0 2.1 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Frag1 PF10277.9 ETS63018.1 - 1.3e-38 132.7 19.7 1.6e-38 132.5 19.7 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family PHO4 PF01384.20 ETS63018.1 - 0.0042 16.2 1.4 0.0054 15.8 1.4 1.3 1 0 0 1 1 1 1 Phosphate transporter family TarH PF02203.15 ETS63018.1 - 0.6 10.0 1.8 1.2 9.0 1.8 1.6 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF4131 PF13567.6 ETS63018.1 - 6.1 6.5 11.4 23 4.6 4.8 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Aminotran_1_2 PF00155.21 ETS63019.1 - 3.5e-16 59.3 0.0 4.4e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ETS63019.1 - 1.5e-08 33.8 0.0 4.4e-08 32.3 0.0 1.7 2 0 0 2 2 2 1 Alanine-glyoxylate amino-transferase NCA2 PF08637.10 ETS63020.1 - 1.9e-81 273.4 4.4 2.8e-80 269.6 0.1 3.0 3 0 0 3 3 3 2 ATP synthase regulation protein NCA2 Thioredoxin PF00085.20 ETS63021.1 - 6.7e-60 199.5 0.1 1.3e-29 102.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 ETS63021.1 - 1.3e-21 77.2 0.8 5.7e-21 75.2 0.8 2.2 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 ETS63021.1 - 5.8e-17 62.0 0.0 1.7e-07 30.9 0.0 2.3 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ETS63021.1 - 3.8e-13 49.9 0.2 2e-05 25.0 0.2 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ETS63021.1 - 1.7e-08 34.7 1.9 0.047 14.0 0.0 4.3 4 2 1 5 5 4 3 Thioredoxin-like AhpC-TSA PF00578.21 ETS63021.1 - 1.7e-08 34.4 0.1 0.0034 17.3 0.0 3.1 3 0 0 3 3 3 2 AhpC/TSA family Thioredoxin_7 PF13899.6 ETS63021.1 - 1.1e-07 31.9 0.6 0.0003 20.9 0.1 3.2 3 0 0 3 3 3 2 Thioredoxin-like HyaE PF07449.11 ETS63021.1 - 1.3e-06 28.3 0.0 0.00043 20.2 0.0 2.5 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 ETS63021.1 - 3.2e-06 27.1 0.6 0.0011 18.8 0.0 2.7 3 0 0 3 3 3 2 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 ETS63021.1 - 0.00043 20.1 0.4 0.99 9.2 0.0 2.7 3 0 0 3 3 3 2 Thioredoxin Redoxin PF08534.10 ETS63021.1 - 0.0023 17.7 0.1 1.4 8.6 0.0 2.6 2 0 0 2 2 2 2 Redoxin DIM PF08194.12 ETS63021.1 - 0.022 14.9 2.7 0.05 13.8 2.7 1.6 1 0 0 1 1 1 0 DIM protein CotE PF10628.9 ETS63021.1 - 0.043 13.5 0.5 0.094 12.4 0.5 1.5 1 0 0 1 1 1 0 Outer spore coat protein E (CotE) TetR_C_5 PF08360.11 ETS63021.1 - 0.084 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Thioredoxin_4 PF13462.6 ETS63021.1 - 5.7 7.1 10.1 1.9 8.6 0.1 3.6 3 2 1 4 4 4 0 Thioredoxin XPG_I_2 PF12813.7 ETS63022.1 - 2.3e-06 27.3 0.3 3.2e-05 23.5 0.3 2.2 1 1 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 ETS63022.1 - 6.1e-05 23.4 0.0 0.0096 16.4 0.0 2.5 2 0 0 2 2 2 2 XPG N-terminal domain 5_3_exonuc_N PF02739.16 ETS63022.1 - 0.044 13.7 0.0 5 7.0 0.0 2.6 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain Lactamase_B PF00753.27 ETS63023.1 - 1.7e-15 57.6 2.1 4.4e-15 56.2 2.1 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 ETS63023.1 - 1e-06 28.6 0.0 4.8e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 ETS63023.1 - 0.0029 17.1 0.1 0.006 16.1 0.1 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Pinin_SDK_N PF04697.13 ETS63023.1 - 0.16 12.6 0.0 0.29 11.8 0.0 1.4 1 0 0 1 1 1 0 pinin/SDK conserved region Evr1_Alr PF04777.13 ETS63024.1 - 5.6e-27 94.1 0.2 9.4e-27 93.4 0.2 1.4 1 0 0 1 1 1 1 Erv1 / Alr family Glyco_hydro_cc PF11790.8 ETS63025.1 - 2.4e-44 151.7 0.1 3.3e-44 151.3 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Apt1 PF10351.9 ETS63025.1 - 0.017 14.0 17.0 0.025 13.4 17.0 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ETS63025.1 - 0.2 10.2 28.8 0.28 9.7 28.8 1.1 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 ETS63025.1 - 1.1 7.3 7.2 1.7 6.7 7.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETS63025.1 - 1.9 7.2 8.2 2.8 6.6 8.2 1.2 1 0 0 1 1 1 0 Presenilin CIA30 PF08547.12 ETS63026.1 - 4.4e-23 82.1 0.0 2.6e-10 40.5 0.0 2.4 2 0 0 2 2 2 2 Complex I intermediate-associated protein 30 (CIA30) Aldose_epim PF01263.20 ETS63026.1 - 2.1e-10 40.4 0.0 1.7e-08 34.1 0.0 2.8 1 1 0 1 1 1 1 Aldose 1-epimerase SGBP_B_XBD PF18329.1 ETS63026.1 - 0.11 12.4 0.1 0.28 11.1 0.1 1.6 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain His_Phos_2 PF00328.22 ETS63027.1 - 9.1e-08 31.8 0.0 8e-05 22.2 0.0 2.3 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) zf-BED PF02892.15 ETS63027.1 - 0.19 11.8 0.0 0.48 10.5 0.0 1.6 1 0 0 1 1 1 0 BED zinc finger Acatn PF13000.7 ETS63028.1 - 1.2e-159 532.3 23.2 1.2e-79 268.3 14.8 3.4 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 Peptidase_M48 PF01435.18 ETS63029.1 - 8.5e-32 110.5 0.0 2.5e-31 109.0 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M48 HTH_1 PF00126.27 ETS63029.1 - 0.041 13.9 0.5 15 5.7 0.0 2.9 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family CbiJ PF02571.14 ETS63029.1 - 0.18 11.2 0.1 0.43 10.0 0.0 1.6 2 0 0 2 2 2 0 Precorrin-6x reductase CbiJ/CobK adh_short PF00106.25 ETS63030.1 - 4e-22 78.6 2.8 2.8e-10 40.0 0.6 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63030.1 - 3.4e-14 53.0 1.0 2.1e-06 27.5 0.0 2.5 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63030.1 - 7.3e-05 22.7 0.0 0.00014 21.8 0.0 1.5 1 0 0 1 1 1 1 KR domain FtsJ PF01728.19 ETS63031.1 - 4e-64 216.0 0.0 5.7e-64 215.5 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase rRNA_processing PF08524.11 ETS63032.1 - 7.2e-11 42.3 7.5 3.8e-06 27.0 0.1 2.4 2 0 0 2 2 2 2 rRNA processing Methyltransf_PK PF05891.12 ETS63033.1 - 2.9e-61 206.8 0.0 3.6e-34 118.2 0.0 3.0 2 1 0 2 2 2 2 AdoMet dependent proline di-methyltransferase Methyltransf_23 PF13489.6 ETS63033.1 - 5.1e-08 32.9 0.0 7.7e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63033.1 - 1.4e-06 28.9 0.0 0.01 16.5 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ETS63033.1 - 8.7e-06 26.4 0.0 0.0071 17.1 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ETS63033.1 - 0.0001 22.9 0.0 0.02 15.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 ETS63033.1 - 0.012 14.9 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain GRDP-like PF07173.12 ETS63034.1 - 1.7e-16 61.2 0.1 1.6e-13 51.5 0.0 3.3 2 1 1 3 3 3 2 Glycine-rich domain-containing protein-like Glyco_transf_15 PF01793.16 ETS63036.1 - 5e-110 367.8 2.8 6.2e-110 367.5 2.8 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase adh_short_C2 PF13561.6 ETS63037.1 - 3.9e-53 180.4 8.7 1.3e-25 90.3 3.0 3.0 1 1 2 3 3 3 3 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS63037.1 - 2.2e-49 167.6 6.1 6.3e-32 110.6 1.5 2.1 1 1 1 2 2 2 2 short chain dehydrogenase KR PF08659.10 ETS63037.1 - 4.7e-09 36.4 5.3 1.1e-05 25.4 1.0 2.3 1 1 1 2 2 2 2 KR domain 3HCDH_N PF02737.18 ETS63037.1 - 0.0086 16.0 1.1 0.015 15.2 1.1 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ETS63037.1 - 0.058 13.0 0.3 0.095 12.3 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Peptidase_M24 PF00557.24 ETS63038.1 - 1.8e-46 158.5 0.1 2.2e-46 158.2 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Abhydrolase_1 PF00561.20 ETS63039.1 - 8.5e-15 55.1 0.1 4.4e-13 49.5 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS63039.1 - 1.6e-12 48.5 0.2 2.2e-12 48.1 0.2 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS63039.1 - 4.9e-09 35.8 0.0 6.5e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 ETS63039.1 - 1.7e-08 34.5 0.2 1.1e-06 28.6 0.2 2.5 2 1 0 2 2 2 1 PGAP1-like protein Thioesterase PF00975.20 ETS63039.1 - 4.8e-06 26.9 0.0 6.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Chlorophyllase2 PF12740.7 ETS63039.1 - 0.0097 14.8 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme DUF676 PF05057.14 ETS63039.1 - 0.015 14.9 0.0 0.024 14.1 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ETS63039.1 - 0.096 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase LRV PF01816.17 ETS63039.1 - 0.13 12.7 0.1 0.38 11.2 0.1 1.8 1 0 0 1 1 1 0 Leucine rich repeat variant Chlorophyllase PF07224.11 ETS63039.1 - 0.17 10.9 0.0 0.27 10.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase Torsin PF06309.11 ETS63041.1 - 3.1e-05 24.1 0.0 0.0003 20.9 0.0 2.4 3 0 0 3 3 3 1 Torsin AAA_33 PF13671.6 ETS63041.1 - 0.00028 21.1 0.0 0.00058 20.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain MobB PF03205.14 ETS63041.1 - 0.0003 20.7 0.0 0.0031 17.4 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.22 ETS63041.1 - 0.00046 19.9 0.1 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Zeta_toxin PF06414.12 ETS63041.1 - 0.0017 17.7 0.0 0.003 16.9 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin TsaE PF02367.17 ETS63041.1 - 0.0032 17.5 0.0 0.0059 16.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE KTI12 PF08433.10 ETS63041.1 - 0.004 16.6 0.0 0.0062 16.0 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 ETS63041.1 - 0.0042 17.5 0.1 0.0062 16.9 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ETS63041.1 - 0.0047 17.5 0.0 0.014 16.0 0.0 1.7 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 ETS63041.1 - 0.0051 16.7 0.0 0.0081 16.1 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase NTPase_1 PF03266.15 ETS63041.1 - 0.0055 16.6 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 NTPase Cytidylate_kin PF02224.18 ETS63041.1 - 0.0072 16.1 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase PRK PF00485.18 ETS63041.1 - 0.0073 16.1 0.0 0.059 13.1 0.0 2.2 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family ATP_bind_1 PF03029.17 ETS63041.1 - 0.0074 16.1 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 ETS63041.1 - 0.0086 15.8 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain LpxK PF02606.14 ETS63041.1 - 0.0095 15.1 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase AAA_11 PF13086.6 ETS63041.1 - 0.0096 15.7 0.0 0.017 14.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ETS63041.1 - 0.01 15.9 0.0 0.49 10.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain CLP1_P PF16575.5 ETS63041.1 - 0.02 14.7 0.1 0.036 13.9 0.1 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA PF00004.29 ETS63041.1 - 0.023 15.1 0.0 0.043 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETS63041.1 - 0.027 14.4 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ParA PF10609.9 ETS63041.1 - 0.038 13.4 0.0 0.065 12.7 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase Thymidylate_kin PF02223.17 ETS63041.1 - 0.041 13.5 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 Thymidylate kinase CbiA PF01656.23 ETS63041.1 - 0.042 13.9 0.1 0.098 12.7 0.1 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain T2SSE PF00437.20 ETS63041.1 - 0.042 12.9 0.0 0.066 12.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein cobW PF02492.19 ETS63041.1 - 0.055 13.0 0.0 0.079 12.5 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ETS63041.1 - 0.06 12.3 0.0 0.095 11.7 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 ETS63041.1 - 0.081 13.4 0.0 0.15 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 ETS63041.1 - 0.081 12.9 0.1 0.34 10.9 0.1 2.0 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ETS63041.1 - 0.091 13.2 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA helicase 6PF2K PF01591.18 ETS63041.1 - 0.1 11.9 0.0 0.38 10.0 0.0 1.7 2 0 0 2 2 2 0 6-phosphofructo-2-kinase SMC_N PF02463.19 ETS63041.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_2 PF07724.14 ETS63041.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF938 PF06080.12 ETS63042.1 - 5.5e-32 111.2 0.0 1.9e-31 109.5 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Nucleo_P87 PF07267.11 ETS63044.1 - 6.7 5.4 5.0 1.3 7.8 0.3 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus capsid protein P87 His_Phos_2 PF00328.22 ETS63045.1 - 2.6e-16 60.0 0.0 4e-16 59.4 0.0 1.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) SPC12 PF06645.13 ETS63046.1 - 5.6e-28 96.8 0.2 6.4e-28 96.6 0.2 1.0 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) ETRAMP PF09716.10 ETS63046.1 - 0.16 12.1 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Fungal_trans PF04082.18 ETS63047.1 - 6.5e-19 68.0 0.5 1.9e-18 66.5 0.2 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63047.1 - 8.8e-08 32.1 8.7 1.5e-07 31.4 8.7 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_4 PF07993.12 ETS63049.1 - 1.2e-31 109.9 0.0 2.4e-31 108.8 0.0 1.5 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 ETS63049.1 - 1e-26 93.5 0.3 4.3e-26 91.5 0.3 2.0 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 ETS63049.1 - 1.2e-07 31.4 0.0 4.2e-07 29.7 0.0 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 ETS63049.1 - 6.7e-05 23.2 0.0 0.00014 22.1 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 ETS63049.1 - 7.4e-05 22.7 0.2 0.00017 21.6 0.2 1.6 1 0 0 1 1 1 1 KR domain Hydrolase PF00702.26 ETS63050.1 - 3.4e-06 27.5 0.0 5.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS63050.1 - 5.6e-06 26.3 0.0 1.4e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like HTH_53 PF18606.1 ETS63050.1 - 0.041 13.6 0.0 0.08 12.6 0.0 1.5 1 0 0 1 1 1 0 Zap helix turn helix N-terminal domain 7tm_1 PF00001.21 ETS63052.1 - 0.09 12.1 4.7 0.25 10.6 4.7 1.7 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DHHC PF01529.20 ETS63053.1 - 6.2e-38 129.9 13.2 1.5e-37 128.7 8.8 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Colicin_V PF02674.16 ETS63053.1 - 0.025 14.5 0.2 0.025 14.5 0.2 2.1 2 0 0 2 2 2 0 Colicin V production protein DZR PF12773.7 ETS63053.1 - 0.63 10.1 7.0 2 8.5 7.0 1.8 1 0 0 1 1 1 0 Double zinc ribbon LIM PF00412.22 ETS63054.1 - 2.6e-20 72.4 16.6 2.4e-11 43.7 6.7 2.3 2 0 0 2 2 2 2 LIM domain DUF4764 PF15961.5 ETS63054.1 - 1 8.0 3.5 7.9 5.0 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4764) Yippee-Mis18 PF03226.14 ETS63054.1 - 5.7 7.2 6.5 25 5.2 2.8 2.5 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PMSR PF01625.21 ETS63055.1 - 7.2e-58 195.1 2.2 9.4e-58 194.7 2.2 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Exo70 PF03081.15 ETS63056.1 - 6.9e-69 232.7 0.0 1.1e-68 232.0 0.0 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit Baculo_PEP_C PF04513.12 ETS63056.1 - 0.89 9.6 4.1 11 6.1 0.3 2.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus SLT PF01464.20 ETS63057.1 - 5.6e-05 22.8 0.1 0.088 12.5 0.0 2.7 2 0 0 2 2 2 2 Transglycosylase SLT domain LigD_N PF13298.6 ETS63057.1 - 0.096 13.0 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase Ligase (LigD) Macoilin PF09726.9 ETS63057.1 - 0.28 9.7 6.9 0.39 9.2 6.9 1.1 1 0 0 1 1 1 0 Macoilin family Thiolase_N PF00108.23 ETS63058.1 - 1.1e-66 224.8 0.1 1.6e-66 224.3 0.1 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETS63058.1 - 4.4e-42 142.6 0.1 7.9e-42 141.8 0.1 1.4 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ETS63058.1 - 0.0014 18.3 0.6 0.0037 16.9 0.6 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Glyco_transf_21 PF13506.6 ETS63058.1 - 0.14 11.6 0.2 0.41 10.1 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 21 Nucleos_tra2_C PF07662.13 ETS63059.1 - 1.4e-64 217.7 7.5 1.4e-64 217.7 7.5 2.5 2 1 1 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 ETS63059.1 - 3e-13 50.2 7.4 3e-13 50.2 7.4 3.2 4 0 0 4 4 4 1 Na+ dependent nucleoside transporter N-terminus Gate PF07670.14 ETS63059.1 - 0.0046 17.2 9.1 0.0046 17.2 9.1 3.7 2 2 2 4 4 4 1 Nucleoside recognition DPM2 PF07297.12 ETS63060.1 - 1.8e-22 79.4 0.1 2e-22 79.3 0.1 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 ETS63060.1 - 2.9e-06 27.2 0.3 3.3e-06 27.0 0.3 1.1 1 0 0 1 1 1 1 PIG-P Phage_holin_3_6 PF07332.11 ETS63060.1 - 0.0038 17.2 2.4 0.0046 17.0 2.4 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF1118 PF06549.12 ETS63060.1 - 0.13 12.6 0.5 0.15 12.4 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1118) MHYT PF03707.16 ETS63060.1 - 0.17 12.1 0.3 0.17 12.1 0.3 2.1 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat Peptidase_S24 PF00717.23 ETS63062.1 - 2.2e-05 24.3 0.0 0.0015 18.4 0.0 2.2 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 ETS63062.1 - 0.0017 18.1 0.0 0.018 14.8 0.0 2.2 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 Macoilin PF09726.9 ETS63062.1 - 5.6 5.4 4.7 7.5 5.0 4.7 1.1 1 0 0 1 1 1 0 Macoilin family DUF3425 PF11905.8 ETS63063.1 - 3.5e-11 43.2 0.2 3.3e-10 40.0 0.2 2.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ETS63063.1 - 4.2e-08 33.2 8.1 4.2e-08 33.2 8.1 2.2 2 1 0 2 2 2 1 bZIP transcription factor eIF3_subunit PF08597.10 ETS63063.1 - 5.8e-05 23.1 3.1 5.8e-05 23.1 3.1 2.2 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit RNA_pol_Rpc4 PF05132.14 ETS63063.1 - 0.17 12.3 12.2 0.2 12.1 1.3 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETS63063.1 - 0.24 9.7 14.2 0.03 12.6 4.8 2.1 2 0 0 2 2 2 0 CDC45-like protein Spt5_N PF11942.8 ETS63063.1 - 1.1 10.3 18.7 0.23 12.4 11.4 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF966 PF06136.13 ETS63063.1 - 1.5 8.5 11.4 0.22 11.2 3.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF966) GvpL_GvpF PF06386.11 ETS63063.1 - 1.7 8.5 7.4 4 7.3 7.4 1.5 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF EPL1 PF10513.9 ETS63063.1 - 3.7 7.9 13.8 2.9 8.2 4.3 2.9 2 1 0 2 2 2 0 Enhancer of polycomb-like DUF3807 PF12720.7 ETS63063.1 - 9.6 6.4 21.0 7.8 6.7 4.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) VHS PF00790.19 ETS63064.1 - 1.3e-26 93.2 0.0 2.9e-26 92.0 0.0 1.6 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 ETS63064.1 - 9.8e-07 29.0 0.5 1.3e-05 25.4 0.9 2.4 2 0 0 2 2 2 1 GAT domain Tfb4 PF03850.14 ETS63064.1 - 0.58 9.6 2.6 1.1 8.7 2.6 1.4 1 0 0 1 1 1 0 Transcription factor Tfb4 Band_3_cyto PF07565.13 ETS63064.1 - 0.98 9.2 6.6 2.1 8.1 6.5 1.7 1 1 0 1 1 1 0 Band 3 cytoplasmic domain Nop14 PF04147.12 ETS63065.1 - 0.75 7.9 18.7 1.1 7.3 18.7 1.2 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 ETS63065.1 - 2.3 8.0 14.6 5.9 6.6 14.6 1.8 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETS63065.1 - 7.8 4.7 15.2 15 3.8 15.2 1.4 1 0 0 1 1 1 0 CDC45-like protein HAUS6_N PF14661.6 ETS63065.1 - 7.8 6.0 15.4 14 5.2 15.4 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Carn_acyltransf PF00755.20 ETS63066.1 - 1.2e-210 701.1 0.0 1.4e-210 700.8 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF1505 PF07403.11 ETS63067.1 - 0.21 11.8 0.8 0.78 9.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1505) Ofd1_CTDD PF10637.9 ETS63069.1 - 2.2e-93 312.3 0.0 6.8e-89 297.6 0.0 2.2 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 ETS63069.1 - 5.1e-33 113.6 0.0 1.8e-32 111.8 0.0 2.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ETS63069.1 - 1.6e-16 61.0 0.1 4.8e-15 56.2 0.0 2.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily zf-CHY PF05495.12 ETS63069.1 - 7.7e-11 42.3 12.2 1.5e-10 41.4 12.2 1.4 1 0 0 1 1 1 1 CHY zinc finger zf-FPG_IleRS PF06827.14 ETS63069.1 - 0.027 14.4 1.0 0.062 13.2 1.0 1.7 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Cys_rich_KTR PF14205.6 ETS63069.1 - 0.2 11.5 3.8 7.3 6.5 0.1 2.4 1 1 1 2 2 2 0 Cysteine-rich KTR SCP2 PF02036.17 ETS63070.1 - 2.4e-16 60.1 0.0 3.7e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ETS63070.1 - 0.013 15.8 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal GPI-anchored PF10342.9 ETS63071.1 - 2.6e-09 37.7 1.6 4.8e-09 36.9 0.0 2.1 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Abhydrolase_1 PF00561.20 ETS63072.1 - 4.6e-17 62.5 0.0 1.8e-16 60.5 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS63072.1 - 3.6e-05 24.5 2.9 6.3e-05 23.7 2.9 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ETS63072.1 - 0.00075 19.1 0.0 0.0016 18.1 0.0 1.5 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ETS63072.1 - 0.001 18.4 0.0 0.034 13.4 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETS63072.1 - 0.0093 15.5 0.0 0.079 12.4 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family EHN PF06441.12 ETS63073.1 - 6.3e-28 97.3 0.3 1.2e-27 96.4 0.3 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ETS63073.1 - 3.9e-10 39.8 0.1 6.3e-10 39.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold PhzC-PhzF PF02567.16 ETS63074.1 - 6.2e-46 157.1 0.0 7.6e-46 156.8 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein PhoD PF09423.10 ETS63075.1 - 2.2e-93 313.1 7.7 3.8e-93 312.3 7.7 1.4 1 1 0 1 1 1 1 PhoD-like phosphatase PhoD_N PF16655.5 ETS63075.1 - 2.6e-24 85.6 0.1 6.8e-24 84.2 0.1 1.8 1 0 0 1 1 1 1 PhoD-like phosphatase, N-terminal domain Pur_ac_phosph_N PF16656.5 ETS63075.1 - 1.2e-07 32.2 0.7 1.2e-07 32.2 0.7 2.3 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain DUF5012 PF16404.5 ETS63075.1 - 0.031 14.4 0.2 0.086 13.0 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5012) Phytase-like PF13449.6 ETS63076.1 - 7.4e-30 104.9 0.0 1.2e-29 104.2 0.0 1.3 1 0 0 1 1 1 1 Esterase-like activity of phytase Mito_carr PF00153.27 ETS63077.1 - 2.5e-33 113.9 13.5 6.8e-14 51.6 0.3 5.2 4 2 0 4 4 4 3 Mitochondrial carrier protein Phage_holin_6_1 PF09682.10 ETS63077.1 - 0.032 14.7 2.6 0.064 13.7 2.6 1.5 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Serine_protease PF18405.1 ETS63077.1 - 0.23 10.6 0.0 0.23 10.6 0.0 2.9 2 1 1 3 3 3 0 Gammaproteobacterial serine protease Dicty_REP PF05086.12 ETS63077.1 - 2.5 6.0 6.0 3.3 5.6 6.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AROS PF15684.5 ETS63077.1 - 2.5 8.7 7.4 1.7 9.2 4.7 2.0 2 0 0 2 2 2 0 Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 GIY-YIG PF01541.24 ETS63078.1 - 2.5e-08 34.1 0.0 4.7e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain Arginase PF00491.21 ETS63079.1 - 1.5e-84 283.8 0.0 2.3e-84 283.2 0.0 1.2 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 ETS63079.1 - 0.15 12.3 0.1 0.25 11.6 0.1 1.3 1 0 0 1 1 1 0 UPF0489 domain FGGY_C PF02782.16 ETS63080.1 - 2.6e-47 161.1 0.0 4.4e-47 160.4 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ETS63080.1 - 4.4e-18 65.7 1.2 3.8e-16 59.4 1.2 3.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 ETS63080.1 - 3.7e-06 26.7 0.9 8.9e-05 22.1 0.1 2.3 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family PTH2 PF01981.16 ETS63081.1 - 1.4e-38 131.8 0.4 2.6e-26 92.2 0.3 2.1 1 1 1 2 2 2 2 Peptidyl-tRNA hydrolase PTH2 ADH_N PF08240.12 ETS63082.1 - 8.1e-23 80.4 9.3 1.6e-22 79.4 9.3 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS63082.1 - 3.2e-18 66.0 0.0 6.5e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS63082.1 - 7.3e-07 30.3 0.0 1.1e-06 29.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ETS63082.1 - 9.2e-05 21.9 0.1 0.00077 18.9 0.1 2.1 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 ETS63082.1 - 0.0067 15.2 0.0 0.0098 14.7 0.0 1.1 1 0 0 1 1 1 1 Nitrogenase component 1 type Oxidoreductase AlaDh_PNT_C PF01262.21 ETS63082.1 - 0.01 15.2 0.0 0.021 14.1 0.0 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain OSR1_C PF12202.8 ETS63082.1 - 0.028 14.6 1.1 7 6.9 0.1 2.4 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain SBF PF01758.16 ETS63083.1 - 3.3e-49 167.2 11.9 3.3e-49 167.2 11.9 1.7 2 0 0 2 2 2 1 Sodium Bile acid symporter family Bacillus_PapR PF05968.11 ETS63083.1 - 0.34 10.8 1.4 1.3 9.0 0.2 2.4 2 0 0 2 2 2 0 Bacillus PapR protein DUF21 PF01595.20 ETS63083.1 - 0.53 10.0 10.3 0.17 11.6 0.4 3.0 2 1 0 2 2 2 0 Cyclin M transmembrane N-terminal domain p450 PF00067.22 ETS63084.1 - 1.6e-54 185.4 0.0 3.9e-35 121.5 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 DRMBL PF07522.14 ETS63085.1 - 7.1e-27 93.8 0.0 1.3e-26 93.0 0.0 1.4 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 ETS63085.1 - 0.0053 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RNF220 PF15926.5 ETS63085.1 - 0.042 13.5 0.3 0.11 12.1 0.3 1.6 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Lactamase_B PF00753.27 ETS63085.1 - 0.052 13.6 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily zf_C2HC_14 PF18574.1 ETS63085.1 - 0.082 12.7 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 C2HC Zing finger domain zf-Di19 PF05605.12 ETS63085.1 - 0.21 11.9 1.5 5.3 7.4 0.7 2.6 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding PI-PLC-X PF00388.19 ETS63086.1 - 2.8e-45 153.4 0.0 4.2e-45 152.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 ETS63086.1 - 4.9e-38 130.0 0.0 8e-38 129.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 ETS63086.1 - 1.3e-06 28.6 0.0 4.9e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 C2 domain SET PF00856.28 ETS63088.1 - 8.2e-09 36.1 0.1 1.5e-07 31.9 0.0 2.6 2 0 0 2 2 2 1 SET domain Sugar_tr PF00083.24 ETS63089.1 - 4.4e-30 104.9 27.4 1.1e-15 57.5 3.4 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETS63089.1 - 7.4e-19 67.9 49.7 3.5e-12 45.9 27.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_S9 PF00326.21 ETS63090.1 - 4.7e-06 26.2 0.1 1e-05 25.2 0.1 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ETS63090.1 - 0.0014 17.9 0.0 0.0038 16.5 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS63090.1 - 0.024 14.3 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Tannase PF07519.11 ETS63090.1 - 0.064 12.2 0.2 0.12 11.3 0.2 1.4 1 1 0 1 1 1 0 Tannase and feruloyl esterase DUF4115 PF13464.6 ETS63090.1 - 0.12 12.5 0.0 0.35 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) GMC_oxred_N PF00732.19 ETS63091.1 - 3e-75 253.4 0.0 3.8e-75 253.0 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS63091.1 - 9.6e-38 129.9 0.1 1.7e-37 129.1 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase NAD_binding_8 PF13450.6 ETS63091.1 - 0.0028 17.8 0.1 0.011 15.9 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ETS63091.1 - 0.0046 16.0 0.2 0.0078 15.3 0.2 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 ETS63091.1 - 0.007 16.0 0.3 0.046 13.3 0.1 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS63091.1 - 0.026 13.8 0.0 2.9 7.0 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETS63091.1 - 0.034 13.4 0.0 0.13 11.5 0.0 1.9 2 0 0 2 2 2 0 Thi4 family FAD_binding_2 PF00890.24 ETS63091.1 - 0.091 11.8 0.1 0.091 11.8 0.1 2.5 3 0 0 3 3 3 0 FAD binding domain TrkA_N PF02254.18 ETS63091.1 - 0.17 12.2 0.0 0.82 10.0 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain Lactamase_B_2 PF12706.7 ETS63092.1 - 3.1e-28 98.7 0.0 1.2e-27 96.7 0.0 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Methyltransf_31 PF13847.6 ETS63092.1 - 1e-17 64.3 0.0 1.8e-17 63.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS63092.1 - 4.6e-07 30.5 0.0 1.2e-06 29.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63092.1 - 4.7e-06 27.2 0.0 1.1e-05 26.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETS63092.1 - 5.5e-05 23.2 0.0 8.4e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Lactamase_B_3 PF13483.6 ETS63092.1 - 6.4e-05 22.9 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Methyltransf_23 PF13489.6 ETS63092.1 - 0.018 14.9 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ETS63092.1 - 0.038 13.5 0.0 0.15 11.6 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase small domain Methyltransf_11 PF08241.12 ETS63092.1 - 0.058 14.0 0.0 0.13 12.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain UPF0052 PF01933.18 ETS63093.1 - 3.5e-41 141.3 0.0 7.3e-41 140.3 0.0 1.5 1 1 0 1 1 1 1 Uncharacterised protein family UPF0052 GalP_UDP_transf PF01087.22 ETS63094.1 - 6.1e-69 232.1 0.5 1e-68 231.4 0.5 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 ETS63094.1 - 1.4e-47 161.6 0.0 2.6e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 ETS63094.1 - 2.1e-06 26.9 0.1 0.0034 16.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4921) HIT PF01230.23 ETS63094.1 - 0.0055 17.4 0.1 0.015 16.0 0.1 1.7 1 0 0 1 1 1 1 HIT domain DUF2781 PF10914.8 ETS63095.1 - 9.3e-35 120.2 5.4 1.1e-34 120.0 5.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Zn_clus PF00172.18 ETS63096.1 - 1.7e-06 28.0 11.3 3.5e-06 27.0 11.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Exo_endo_phos PF03372.23 ETS63098.1 - 0.0028 17.2 0.0 0.013 15.0 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1682 PF07946.14 ETS63099.1 - 2.2e-88 296.6 0.0 2.5e-88 296.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) adh_short PF00106.25 ETS63100.1 - 1.2e-26 93.4 0.0 8.7e-24 84.1 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63100.1 - 5e-13 49.1 0.0 6e-12 45.6 0.0 2.0 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63100.1 - 2.8e-08 33.9 0.1 5.6e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS63100.1 - 0.00042 19.8 0.0 0.00052 19.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS63100.1 - 0.0063 15.9 0.0 0.009 15.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Pmp3 PF01679.17 ETS63101.1 - 3.1e-12 46.5 6.5 4.7e-12 45.9 6.5 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RRS1 PF04939.12 ETS63101.1 - 0.17 11.7 3.8 0.21 11.5 0.4 2.2 2 0 0 2 2 2 0 Ribosome biogenesis regulatory protein (RRS1) Thioredoxin_4 PF13462.6 ETS63102.1 - 9.3e-05 22.6 0.0 0.0048 17.1 0.0 2.4 2 1 0 2 2 2 2 Thioredoxin DSBA PF01323.20 ETS63102.1 - 0.029 14.1 0.2 0.86 9.4 0.0 2.4 2 0 0 2 2 2 0 DSBA-like thioredoxin domain MFS_1 PF07690.16 ETS63103.1 - 2.1e-42 145.3 47.8 3.5e-41 141.3 43.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63103.1 - 5.8e-17 61.7 10.9 5.8e-17 61.7 10.9 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ETS63103.1 - 7.5e-13 47.8 11.8 7.5e-13 47.8 11.8 2.5 2 1 1 3 3 3 1 Fungal trichothecene efflux pump (TRI12) Phage-MuB_C PF09077.11 ETS63103.1 - 0.081 12.8 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Mu B transposition protein, C terminal YrhK PF14145.6 ETS63103.1 - 2.2 8.2 7.6 1.4 8.8 0.6 3.3 2 0 0 2 2 2 0 YrhK-like protein ADH_zinc_N PF00107.26 ETS63104.1 - 2.9e-19 69.3 0.8 5.2e-19 68.5 0.8 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS63104.1 - 5.8e-18 66.2 0.2 6.9e-17 62.7 0.1 2.3 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS63104.1 - 2.3e-11 43.5 0.1 6.5e-11 42.1 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ETS63104.1 - 0.0069 16.3 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase PHBC_N PF12551.8 ETS63104.1 - 0.044 13.6 0.3 0.1 12.4 0.3 1.6 1 0 0 1 1 1 0 Poly-beta-hydroxybutyrate polymerase N terminal DAGK_cat PF00781.24 ETS63104.1 - 0.077 12.6 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Peptidase_S10 PF00450.22 ETS63106.1 - 2e-115 386.6 0.3 2.6e-115 386.2 0.3 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1845 PF08900.11 ETS63106.1 - 0.087 12.6 0.1 0.3 10.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1845) Pox_A31 PF05771.11 ETS63108.1 - 0.16 12.0 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 Poxvirus A31 protein Peptidase_S10 PF00450.22 ETS63109.1 - 4e-78 263.7 0.1 5.4e-78 263.2 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Sugar_tr PF00083.24 ETS63110.1 - 4e-80 269.9 12.3 5.2e-80 269.5 12.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS63110.1 - 4.2e-19 68.7 22.3 3.1e-12 46.1 7.8 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily GTP_EFTU PF00009.27 ETS63111.1 - 1.5e-47 161.7 0.0 2.2e-47 161.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 ETS63111.1 - 2.5e-37 127.3 0.6 4.2e-37 126.6 0.6 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 ETS63111.1 - 1.6e-17 63.3 0.0 3.6e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETS63111.1 - 3.5e-08 33.7 0.1 6.4e-08 32.9 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ETS63111.1 - 0.0021 18.1 0.0 0.0053 16.8 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 ETS63111.1 - 0.0022 17.8 0.0 0.0043 16.9 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain ICL PF00463.21 ETS63112.1 - 1.7e-187 624.1 0.2 2e-187 623.9 0.2 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 ETS63112.1 - 7.7e-10 38.6 0.1 4.1e-09 36.3 0.0 2.1 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF2458 PF10454.9 ETS63112.1 - 0.0082 15.8 0.2 0.024 14.3 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) SNCAIP_SNCA_bd PF16700.5 ETS63112.1 - 0.046 13.5 0.0 4.4 7.1 0.0 2.9 3 0 0 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain Methyltransf_16 PF10294.9 ETS63113.1 - 2e-14 53.7 0.0 4e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ETS63113.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain NAD_binding_8 PF13450.6 ETS63113.1 - 0.094 13.0 0.1 0.33 11.2 0.1 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Methyltransf_12 PF08242.12 ETS63113.1 - 0.12 13.2 0.1 0.93 10.3 0.1 2.4 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ETS63113.1 - 0.17 11.7 0.0 0.35 10.7 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain DUF4786 PF16027.5 ETS63115.1 - 0.065 13.8 1.3 0.083 13.5 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4786) Pet191_N PF10203.9 ETS63116.1 - 4.5e-21 74.9 2.6 7.3e-21 74.2 2.6 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Abhydrolase_6 PF12697.7 ETS63116.1 - 0.0073 16.9 3.9 0.0073 16.9 3.9 2.2 1 1 0 2 2 2 1 Alpha/beta hydrolase family DUF1205 PF06722.12 ETS63116.1 - 0.066 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1205) MFS_1 PF07690.16 ETS63118.1 - 1.1e-31 110.1 38.4 1.1e-31 110.1 38.4 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETS63118.1 - 9.9e-06 24.2 1.0 1.6e-05 23.6 1.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Acyl_transf_3 PF01757.22 ETS63119.1 - 1.4e-10 40.8 41.3 1.9e-10 40.3 39.7 2.0 2 0 0 2 2 2 1 Acyltransferase family DUF4381 PF14316.6 ETS63119.1 - 0.029 14.6 0.1 0.52 10.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) CoA_binding PF02629.19 ETS63120.1 - 1.8e-20 73.4 1.1 3e-20 72.7 1.1 1.3 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 ETS63120.1 - 1.3e-11 44.6 0.0 3.1e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 ETS63120.1 - 0.0013 18.5 0.0 0.0029 17.4 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.22 ETS63120.1 - 0.0046 17.8 0.1 0.009 16.8 0.1 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding_2 PF13380.6 ETS63120.1 - 0.018 15.6 0.0 0.035 14.6 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain Ligase_CoA PF00549.19 ETS63121.1 - 2.8e-10 40.2 0.5 4.8e-10 39.4 0.5 1.3 1 0 0 1 1 1 1 CoA-ligase Peptidase_C12 PF01088.21 ETS63122.1 - 1.5e-52 178.5 0.0 1.7e-52 178.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Med10 PF09748.9 ETS63123.1 - 2e-26 92.4 0.0 2.9e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex KorB PF08535.10 ETS63123.1 - 0.019 15.0 0.4 1.7 8.8 0.2 2.3 1 1 1 2 2 2 0 KorB domain DUF2236 PF09995.9 ETS63124.1 - 1.5e-09 38.4 0.2 2.2e-09 37.8 0.2 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) CBFD_NFYB_HMF PF00808.23 ETS63125.1 - 1.7e-18 66.7 0.7 2.6e-18 66.1 0.7 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ETS63125.1 - 8.4e-13 48.8 2.3 1.4e-12 48.1 0.1 2.3 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 tRNA-synt_2 PF00152.20 ETS63126.1 - 8.4e-73 245.2 0.0 1.5e-72 244.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 ETS63126.1 - 8.7e-16 57.8 0.1 1.2e-15 57.3 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 ETS63126.1 - 4.4e-07 29.8 0.1 1.2e-06 28.4 0.1 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ETS63126.1 - 0.02 14.4 0.2 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) NECFESHC PF16621.5 ETS63126.1 - 0.35 10.9 3.2 2.2 8.3 3.3 2.2 1 1 0 1 1 1 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 His_Phos_1 PF00300.22 ETS63127.1 - 1.5e-11 44.3 0.3 3.8e-05 23.5 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) ADH_zinc_N PF00107.26 ETS63128.1 - 6.4e-23 81.2 0.0 1.6e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ETS63128.1 - 1.8e-13 50.3 0.0 4e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ETS63128.1 - 4.8e-09 37.4 0.0 9.4e-09 36.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AFOR_C PF01314.18 ETS63128.1 - 0.00075 18.6 0.2 0.001 18.2 0.2 1.1 1 0 0 1 1 1 1 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 ELFV_dehydrog PF00208.21 ETS63128.1 - 0.025 14.3 0.5 0.036 13.8 0.5 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ysc84 PF04366.12 ETS63129.1 - 7e-33 113.1 0.0 1.5e-32 112.1 0.0 1.6 1 0 0 1 1 1 1 Las17-binding protein actin regulator HAD PF12710.7 ETS63129.1 - 3.6e-06 27.5 1.3 4.8e-06 27.1 0.3 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4683 PF15735.5 ETS63129.1 - 0.067 12.8 0.9 0.11 12.1 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) RskA PF10099.9 ETS63131.1 - 0.004 17.5 0.5 0.0053 17.1 0.5 1.2 1 0 0 1 1 1 1 Anti-sigma-K factor rskA ECH_1 PF00378.20 ETS63132.1 - 1.4e-36 126.1 0.0 2.3e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS63132.1 - 3.7e-17 62.8 0.0 2.3e-16 60.2 0.0 1.8 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase PWI PF01480.17 ETS63133.1 - 4e-31 107.1 0.0 5.7e-31 106.7 0.0 1.2 1 0 0 1 1 1 1 PWI domain Hydin_ADK PF17213.3 ETS63134.1 - 3.5 7.8 11.6 4.3 7.6 10.3 1.8 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF4834 PF16118.5 ETS63135.1 - 0.14 13.2 0.1 0.39 11.7 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) dCMP_cyt_deam_1 PF00383.23 ETS63136.1 - 4.6e-14 52.1 0.0 1.1e-13 51.0 0.0 1.6 1 1 1 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 ETS63136.1 - 2e-11 44.2 1.0 2.2e-08 34.4 0.1 2.2 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 ETS63136.1 - 0.0022 17.6 1.0 0.033 13.8 0.0 2.3 1 1 1 2 2 2 1 A distinct subfamily of CDD/CDA-like deaminases MFS_1 PF07690.16 ETS63137.1 - 1e-19 70.7 24.8 4.1e-14 52.3 12.4 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily NTP_transf_9 PF04248.12 ETS63137.1 - 5.3e-19 67.9 0.0 9.7e-19 67.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF427) Sugar_tr PF00083.24 ETS63137.1 - 1.8e-05 23.8 0.0 1.8e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter ATG22 PF11700.8 ETS63137.1 - 0.00023 19.9 4.8 0.00023 19.9 4.8 2.3 2 0 0 2 2 2 2 Vacuole effluxer Atg22 like Penaeidin PF05927.11 ETS63138.1 - 0.051 14.3 0.6 0.15 12.8 0.6 1.8 1 1 0 1 1 1 0 Penaeidin FGGY_C PF02782.16 ETS63139.1 - 1.4e-15 57.6 0.0 3.1e-15 56.4 0.0 1.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ETS63139.1 - 8.1e-09 35.4 0.0 7.5e-06 25.7 0.0 3.4 2 1 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain NMO PF03060.15 ETS63140.1 - 2.5e-37 129.0 3.9 9.7e-28 97.5 0.2 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase CoA_transf_3 PF02515.17 ETS63141.1 - 8.4e-125 416.7 0.0 1.2e-124 416.2 0.0 1.2 1 0 0 1 1 1 1 CoA-transferase family III Got1 PF04178.12 ETS63142.1 - 1.5e-23 83.4 22.9 2e-23 83.0 22.9 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family DUF3040 PF11239.8 ETS63142.1 - 0.069 13.4 0.7 0.069 13.4 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF3021 PF11457.8 ETS63142.1 - 0.19 12.0 22.2 0.3 11.4 22.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF2157 PF09925.9 ETS63142.1 - 0.43 10.4 15.2 0.57 10.0 15.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Zn_clus PF00172.18 ETS63143.1 - 0.00017 21.6 10.3 0.00034 20.7 10.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ETS63143.1 - 0.0042 17.1 0.0 0.013 15.5 0.0 1.8 1 0 0 1 1 1 1 PAS fold Allantoicase PF03561.15 ETS63144.1 - 2e-85 284.0 0.0 6.8e-42 142.9 0.0 2.4 2 0 0 2 2 2 2 Allantoicase repeat Ureidogly_lyase PF04115.12 ETS63144.1 - 1.4e-50 171.7 0.0 2.1e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 Ureidoglycolate lyase PAF-AH_p_II PF03403.13 ETS63144.1 - 3.3e-48 164.1 0.0 2.3e-44 151.5 0.0 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 ETS63144.1 - 2.6e-05 23.6 0.1 0.18 11.0 0.1 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ETS63144.1 - 0.027 13.4 0.0 0.52 9.2 0.0 2.2 2 0 0 2 2 2 0 Chlorophyllase enzyme Esterase PF00756.20 ETS63144.1 - 0.028 14.1 0.2 0.078 12.6 0.0 1.7 2 0 0 2 2 2 0 Putative esterase Abhydrolase_6 PF12697.7 ETS63144.1 - 4.1 7.9 17.7 0.024 15.2 4.7 3.8 3 1 0 3 3 3 0 Alpha/beta hydrolase family PRT_C PF08372.10 ETS63145.1 - 0.24 11.1 1.7 3.3 7.4 0.3 2.4 2 0 0 2 2 2 0 Plant phosphoribosyltransferase C-terminal SNARE PF05739.19 ETS63147.1 - 2.4e-07 30.7 0.0 4.1e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 SNARE domain DNA_pol_B PF00136.21 ETS63148.1 - 1.8e-100 336.8 0.0 2.5e-100 336.4 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ETS63148.1 - 1.8e-23 83.2 0.0 1.5e-11 44.1 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ETS63148.1 - 9.2e-12 45.3 9.3 1.9e-11 44.2 9.3 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta MutL_C PF08676.11 ETS63149.1 - 1.5e-22 79.9 0.0 4.7e-22 78.3 0.0 1.9 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ETS63149.1 - 1.5e-19 69.8 0.0 3.5e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ETS63149.1 - 3.7e-10 39.8 0.0 8.1e-10 38.7 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ETS63149.1 - 6.5e-05 23.4 0.0 0.00016 22.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3585 PF12130.8 ETS63150.1 - 0.05 13.7 5.4 0.23 11.6 5.4 1.8 1 1 0 1 1 1 0 Bivalent Mical/EHBP Rab binding domain ArsR PF09824.9 ETS63150.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 ArsR transcriptional regulator FIN1 PF17300.2 ETS63150.1 - 0.29 10.6 3.1 0.65 9.5 3.1 1.4 1 1 0 1 1 1 0 Filaments in between nuclei protein-1 Enkurin PF13864.6 ETS63150.1 - 0.5 10.8 4.5 2.7 8.5 4.1 2.0 1 1 1 2 2 2 0 Calmodulin-binding ERG2_Sigma1R PF04622.12 ETS63151.1 - 3.3e-89 297.8 0.0 3.9e-89 297.5 0.0 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Rhodanese PF00581.20 ETS63152.1 - 1.3e-05 25.7 0.0 3.4e-05 24.3 0.0 1.8 1 1 0 1 1 1 1 Rhodanese-like domain KduI PF04962.12 ETS63152.1 - 0.017 14.4 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 KduI/IolB family ECH_1 PF00378.20 ETS63153.1 - 1.7e-51 175.0 0.0 2.1e-51 174.7 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS63153.1 - 1.9e-25 90.1 0.1 1.5e-22 80.6 0.0 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase AMP-binding PF00501.28 ETS63155.1 - 1e-79 268.1 0.1 1e-53 182.5 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ETS63155.1 - 1.3e-11 45.3 0.1 1.4e-10 42.0 0.1 2.5 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Metallophos PF00149.28 ETS63156.1 - 4.2e-12 47.0 2.1 7.4e-12 46.2 2.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase EHN PF06441.12 ETS63157.1 - 9.4e-29 100.0 0.1 1.8e-28 99.0 0.1 1.5 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ETS63157.1 - 2.3e-07 30.7 0.1 6e-07 29.4 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS63157.1 - 0.0012 19.5 3.7 0.0064 17.1 3.7 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family Ribosomal_L37 PF08561.10 ETS63158.1 - 1.4e-29 103.0 5.1 2e-29 102.6 5.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 NARP1 PF12569.8 ETS63158.1 - 0.052 12.5 8.2 0.067 12.1 8.2 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CUE PF02845.16 ETS63159.1 - 3.6e-11 42.5 0.0 6.9e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 CUE domain DUF3752 PF12572.8 ETS63159.1 - 0.13 12.8 5.1 0.25 11.8 5.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3752) DUF4834 PF16118.5 ETS63159.1 - 0.14 13.1 0.6 0.61 11.1 0.6 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Abhydrolase_6 PF12697.7 ETS63160.1 - 1.4e-08 35.7 1.2 1.4e-08 35.7 1.2 1.9 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS63160.1 - 0.017 14.4 0.0 0.034 13.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_M19 PF01244.21 ETS63161.1 - 3.4e-87 292.6 0.0 4.2e-87 292.3 0.0 1.1 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Glyco_hydro_31 PF01055.26 ETS63162.1 - 3.7e-79 267.0 0.0 5e-79 266.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ETS63162.1 - 1.4e-09 38.2 0.0 5.1e-09 36.3 0.0 2.0 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 ETS63162.1 - 0.068 13.5 0.0 0.41 10.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5110) MFS_1 PF07690.16 ETS63163.1 - 2.3e-35 122.2 20.9 3e-35 121.8 20.9 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Pox_A14 PF05767.12 ETS63163.1 - 0.078 13.1 1.2 23 5.2 1.2 2.9 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF1180 PF06679.12 ETS63163.1 - 0.1 13.0 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Glyco_hydro_32N PF00251.20 ETS63164.1 - 7.6e-86 288.4 6.1 1.1e-85 287.8 6.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 ETS63164.1 - 1.7e-12 47.6 0.3 3.2e-12 46.7 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal PXA PF02194.15 ETS63165.1 - 1.2e-41 142.6 0.5 4.5e-40 137.5 0.1 2.7 2 1 0 2 2 2 1 PXA domain Nexin_C PF08628.12 ETS63165.1 - 0.00012 22.6 0.0 0.00062 20.3 0.0 2.2 2 0 0 2 2 2 1 Sorting nexin C terminal peroxidase PF00141.23 ETS63166.1 - 5.7e-48 163.6 0.0 8.5e-48 163.0 0.0 1.2 1 0 0 1 1 1 1 Peroxidase DUF5549 PF17703.1 ETS63168.1 - 0.0031 17.2 1.8 0.0031 17.2 1.8 2.6 3 1 0 3 3 3 1 Family of unknown function (DUF5549) Glyco_hydro_88 PF07470.13 ETS63169.1 - 2.1e-74 250.7 0.5 3e-74 250.2 0.5 1.2 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Pec_lyase PF09492.10 ETS63169.1 - 0.14 11.5 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Pectic acid lyase Acetyltransf_3 PF13302.7 ETS63170.1 - 4.9e-13 50.0 0.0 9e-13 49.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS63170.1 - 2.1e-05 24.7 0.0 3.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family GIDE PF12483.8 ETS63170.1 - 0.042 13.2 0.0 0.068 12.6 0.0 1.2 1 0 0 1 1 1 0 E3 Ubiquitin ligase UvdE PF03851.14 ETS63171.1 - 1.1e-85 287.2 0.0 1.6e-85 286.7 0.0 1.2 1 0 0 1 1 1 1 UV-endonuclease UvdE Endomucin PF07010.12 ETS63171.1 - 2.5 8.0 6.8 4.9 7.0 6.8 1.4 1 0 0 1 1 1 0 Endomucin RCC1 PF00415.18 ETS63172.1 - 2.1e-25 89.0 14.6 2.9e-14 53.4 0.0 8.2 8 0 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETS63172.1 - 1.2e-15 56.8 8.1 9e-09 34.9 0.3 6.4 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat 4HBT PF03061.22 ETS63174.1 - 1.5e-10 41.3 0.0 2.5e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily N6-adenineMlase PF10237.9 ETS63175.1 - 2.8e-34 118.3 0.1 8.9e-34 116.6 0.1 1.7 1 1 0 1 1 1 1 Probable N6-adenine methyltransferase AP3D1 PF06375.11 ETS63175.1 - 0.11 12.7 3.2 0.18 12.1 3.2 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 PRELI PF04707.14 ETS63176.1 - 2.1e-40 138.1 0.0 2.5e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family DUF3530 PF12048.8 ETS63176.1 - 0.05 13.0 0.0 0.064 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Glyco_hydro_47 PF01532.20 ETS63177.1 - 4.3e-132 441.3 0.0 5.3e-132 441.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 WES_acyltransf PF03007.16 ETS63179.1 - 9.6e-14 51.8 2.6 5.6e-13 49.3 0.0 2.6 2 1 0 2 2 2 1 Wax ester synthase-like Acyl-CoA acyltransferase domain DUF1298 PF06974.13 ETS63179.1 - 1.1e-09 38.3 0.0 2e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) Fungal_trans_2 PF11951.8 ETS63180.1 - 1.7e-11 43.6 2.0 5.4e-11 41.9 0.0 2.3 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63180.1 - 6.9e-09 35.7 12.5 1.2e-08 35.0 12.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GalKase_gal_bdg PF10509.9 ETS63181.1 - 7.4e-21 73.5 0.1 1.5e-20 72.4 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ETS63181.1 - 8.7e-13 48.3 0.2 8.7e-13 48.3 0.2 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ETS63181.1 - 1.1e-12 48.1 0.1 4.6e-11 42.9 0.0 2.5 2 0 0 2 2 2 1 GHMP kinases C terminal DUF3914 PF13053.6 ETS63181.1 - 0.058 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3914) Zn_clus PF00172.18 ETS63182.1 - 2.1e-05 24.5 11.1 4e-05 23.7 11.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS63182.1 - 0.00026 20.1 0.1 0.00044 19.4 0.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain MFS_1 PF07690.16 ETS63183.1 - 8.9e-35 120.2 53.8 4e-34 118.1 53.4 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63183.1 - 6.6e-09 35.1 14.5 6.6e-09 35.1 14.5 2.5 2 0 0 2 2 2 2 Sugar (and other) transporter FPN1 PF06963.12 ETS63184.1 - 9.2e-138 459.5 11.3 1.1e-137 459.1 11.3 1.1 1 0 0 1 1 1 1 Ferroportin1 (FPN1) ACOX PF01756.19 ETS63185.1 - 1.2e-35 122.7 0.0 6.2e-35 120.4 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ETS63185.1 - 1.2e-19 71.1 0.5 2.3e-19 70.2 0.5 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ETS63185.1 - 1.4e-05 25.2 0.0 2.8e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ETS63185.1 - 0.00016 21.9 0.1 0.00042 20.6 0.1 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain TAL_effector PF03377.13 ETS63185.1 - 0.038 14.3 0.0 0.09 13.1 0.0 1.6 1 0 0 1 1 1 0 TAL effector repeat Pyr_redox_2 PF07992.14 ETS63186.1 - 1.4e-21 77.1 0.3 1.8e-21 76.7 0.3 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS63186.1 - 3.8e-07 30.6 0.9 0.00016 22.2 0.0 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS63186.1 - 1.3e-06 27.9 0.2 0.00019 20.8 0.0 2.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETS63186.1 - 2.3e-06 27.0 0.1 1.4e-05 24.5 0.0 2.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ETS63186.1 - 2.8e-06 26.8 0.2 0.00098 18.4 0.0 2.4 2 0 0 2 2 2 2 Thi4 family DAO PF01266.24 ETS63186.1 - 0.0004 20.1 5.1 0.01 15.4 0.1 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ETS63186.1 - 0.0012 17.7 2.2 0.31 9.7 0.0 3.4 3 1 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 ETS63186.1 - 0.0014 18.8 1.1 0.0049 17.1 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ETS63186.1 - 0.0015 17.7 0.8 0.29 10.1 0.1 2.5 2 1 0 2 2 2 2 Lycopene cyclase protein Trp_halogenase PF04820.14 ETS63186.1 - 0.039 12.8 0.1 0.039 12.8 0.1 1.8 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 ETS63186.1 - 0.04 13.9 5.5 1.3 9.0 0.0 3.6 3 1 0 4 4 4 0 FAD-NAD(P)-binding Arrestin_C PF02752.22 ETS63187.1 - 3.1e-20 73.0 0.0 2.2e-19 70.2 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETS63187.1 - 9.4e-09 35.5 0.0 2.7e-06 27.5 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Sgf11 PF08209.11 ETS63188.1 - 4.2e-15 55.0 0.5 8.9e-15 54.0 0.5 1.6 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Molybdop_Fe4S4 PF04879.16 ETS63188.1 - 0.081 12.9 0.3 0.17 11.9 0.3 1.5 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Fe4S4 domain zf-CpG_bind_C PF12269.8 ETS63188.1 - 0.18 11.6 0.2 0.44 10.3 0.1 1.6 1 1 0 1 1 1 0 CpG binding protein zinc finger C terminal domain zf-C2HC_2 PF13913.6 ETS63188.1 - 3.5 7.6 6.6 0.24 11.4 0.4 2.3 3 0 0 3 3 3 0 zinc-finger of a C2HC-type PPP4R2 PF09184.11 ETS63188.1 - 7.8 6.0 12.9 22 4.5 12.9 1.7 1 1 0 1 1 1 0 PPP4R2 GFA PF04828.14 ETS63190.1 - 8.4e-19 67.7 0.4 1.2e-18 67.2 0.4 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Zn_ribbon_SprT PF17283.2 ETS63190.1 - 0.011 15.7 3.3 0.18 11.7 0.4 2.4 2 1 0 2 2 2 0 SprT-like zinc ribbon domain DZR PF12773.7 ETS63190.1 - 0.016 15.3 4.3 0.067 13.2 0.0 2.3 2 0 0 2 2 2 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ETS63190.1 - 0.023 14.4 3.5 0.084 12.6 0.2 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ETS63190.1 - 0.044 13.7 0.1 0.044 13.7 0.1 2.5 2 0 0 2 2 2 0 Nudix N-terminal zf-ISL3 PF14690.6 ETS63190.1 - 0.27 11.9 4.4 0.82 10.4 0.5 2.4 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn-ribbon_8 PF09723.10 ETS63190.1 - 0.4 10.8 0.1 0.4 10.8 0.1 2.4 2 1 0 2 2 2 0 Zinc ribbon domain NOB1_Zn_bind PF08772.11 ETS63190.1 - 0.45 10.7 7.6 4.4 7.6 7.1 2.3 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DNA_ligase_ZBD PF03119.16 ETS63190.1 - 0.67 10.0 8.4 0.24 11.4 1.4 2.4 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-LITAF-like PF10601.9 ETS63190.1 - 1.3 9.4 8.4 34 4.8 8.4 2.3 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain zinc_ribbon_4 PF13717.6 ETS63190.1 - 2.9 7.9 8.9 0.44 10.5 2.6 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 ETS63190.1 - 5.1 6.8 8.7 0.37 10.5 0.3 2.6 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Cyanate_lyase PF02560.14 ETS63191.1 - 1.2e-33 114.8 0.0 1.7e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_31 PF13560.6 ETS63191.1 - 0.00092 19.5 0.0 0.0013 19.0 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ETS63191.1 - 0.0012 18.9 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix Zn_clus PF00172.18 ETS63192.1 - 1.3e-06 28.5 7.0 2.5e-06 27.5 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 ETS63193.1 - 0.69 8.4 13.0 1.1 7.7 13.0 1.3 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 ETS63193.1 - 3.5 6.4 9.8 4 6.2 9.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 ETS63193.1 - 6.4 5.8 17.7 7.6 5.6 17.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Collagen PF01391.18 ETS63194.1 - 0.068 12.9 36.9 0.3 10.9 36.9 2.1 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) CAP_N PF01213.19 ETS63194.1 - 0.11 12.0 1.1 0.21 11.1 1.1 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal NAD_binding_2 PF03446.15 ETS63195.1 - 1.3e-36 126.2 1.7 1.9e-36 125.6 1.7 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ETS63195.1 - 3e-34 117.9 2.9 5.7e-34 117.0 0.7 2.2 2 1 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 ETS63195.1 - 0.00013 22.4 0.2 0.00037 21.0 0.2 1.9 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ETS63195.1 - 0.00026 20.9 0.3 0.00049 20.0 0.3 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ETS63195.1 - 0.00039 19.8 0.0 0.00066 19.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ETS63195.1 - 0.052 13.1 0.2 0.052 13.1 0.2 1.8 2 1 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 ETS63195.1 - 0.1 12.1 0.1 0.25 10.9 0.1 1.6 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MTS PF05175.14 ETS63197.1 - 5e-10 39.2 0.0 3.8e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_24 PF13578.6 ETS63197.1 - 4e-05 24.6 0.0 0.00011 23.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_33 PF10017.9 ETS63197.1 - 0.00017 20.8 0.0 0.0093 15.1 0.0 2.1 1 1 1 2 2 2 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_25 PF13649.6 ETS63197.1 - 0.0005 20.7 0.0 0.0011 19.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 ETS63197.1 - 0.014 15.2 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_31 PF13847.6 ETS63197.1 - 0.017 14.9 0.0 0.031 14.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ETS63197.1 - 0.076 12.7 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 ETS63197.1 - 0.12 13.1 0.0 0.55 11.0 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain p450 PF00067.22 ETS63198.1 - 1.3e-51 175.8 0.0 3.7e-47 161.1 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 Acyl_transf_1 PF00698.21 ETS63199.1 - 2.7e-14 53.4 2.0 6.7e-11 42.2 0.4 2.4 2 0 0 2 2 2 2 Acyl transferase domain MFS_1 PF07690.16 ETS63200.1 - 3.3e-32 111.8 58.4 9.9e-31 106.9 57.9 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily YlaH PF14036.6 ETS63200.1 - 0.15 12.4 5.9 0.098 13.0 1.7 2.6 2 0 0 2 2 2 0 YlaH-like protein ADH_N PF08240.12 ETS63202.1 - 7.2e-29 99.9 0.6 1.2e-28 99.2 0.6 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS63202.1 - 3.4e-25 88.5 0.4 5.5e-25 87.8 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS63202.1 - 9.8e-09 36.4 0.2 1.9e-08 35.4 0.2 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 ETS63202.1 - 0.057 12.9 0.1 0.14 11.6 0.2 1.6 2 0 0 2 2 2 0 short chain dehydrogenase AlaDh_PNT_C PF01262.21 ETS63202.1 - 0.09 12.1 0.3 0.14 11.4 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain mono-CXXC PF15626.6 ETS63202.1 - 3.3 8.2 5.5 1.3 9.4 0.8 2.3 2 0 0 2 2 2 0 single CXXC unit Thiolase_N PF00108.23 ETS63205.1 - 4.2e-15 55.8 1.0 1e-12 48.0 0.1 2.8 1 1 1 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETS63205.1 - 4.3e-09 36.1 0.6 8.3e-08 31.9 0.1 3.0 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ETS63205.1 - 7.7e-06 25.7 3.2 2.7e-05 23.9 3.2 1.9 1 1 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 ETS63205.1 - 0.0025 17.6 3.1 0.016 15.1 0.4 2.7 3 0 0 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III SpoVAD PF07451.11 ETS63205.1 - 0.0052 15.5 0.2 0.056 12.1 0.3 2.1 2 0 0 2 2 2 1 Stage V sporulation protein AD (SpoVAD) Ketoacyl-synt_C PF02801.22 ETS63205.1 - 0.12 12.4 1.1 0.9 9.6 0.0 2.8 3 0 0 3 3 3 0 Beta-ketoacyl synthase, C-terminal domain GFO_IDH_MocA PF01408.22 ETS63207.1 - 1.1e-18 68.1 0.0 1.7e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CRCB PF02537.15 ETS63208.1 - 4.1e-31 107.1 18.2 6.1e-19 68.1 5.9 2.5 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) Acetyltransf_1 PF00583.25 ETS63209.1 - 0.14 12.4 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family SNF2_N PF00176.23 ETS63211.1 - 1e-43 149.4 0.0 2.3e-43 148.3 0.0 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS63211.1 - 1.1e-08 35.3 0.1 4e-07 30.4 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 ETS63211.1 - 1.7e-06 27.8 10.9 2.9e-06 27.0 10.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS63211.1 - 1.9e-05 24.4 11.9 3.9e-05 23.4 11.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS63211.1 - 4.1e-05 23.4 13.1 7e-05 22.6 13.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS63211.1 - 0.0003 20.6 11.2 0.00054 19.8 11.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ETS63211.1 - 0.0012 18.7 12.6 0.0021 18.0 12.6 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETS63211.1 - 0.0017 18.7 13.8 0.003 17.9 13.8 1.4 1 0 0 1 1 1 1 Ring finger domain zf-UDP PF14569.6 ETS63211.1 - 0.0058 16.7 5.2 0.013 15.6 5.2 1.5 1 0 0 1 1 1 1 Zinc-binding RING-finger zf-RING_UBOX PF13445.6 ETS63211.1 - 0.31 11.1 11.8 0.64 10.1 11.8 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETS63211.1 - 0.34 11.1 10.1 0.66 10.2 10.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 ETS63211.1 - 0.6 9.8 11.0 1.2 8.9 11.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type M20_dimer PF07687.14 ETS63213.1 - 1.8e-11 43.9 1.1 2.6e-11 43.4 0.1 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ETS63213.1 - 2.2e-08 34.1 0.4 4.8e-08 33.0 0.2 1.7 2 0 0 2 2 2 1 Peptidase family M20/M25/M40 CTK3_C PF12350.8 ETS63213.1 - 1 9.6 3.3 0.52 10.5 0.4 1.9 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus NMO PF03060.15 ETS63214.1 - 2.6e-42 145.4 3.6 2.4e-41 142.2 3.6 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase DUF1275 PF06912.11 ETS63214.1 - 1.5e-33 116.4 9.9 2.4e-33 115.7 9.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) IMPDH PF00478.25 ETS63214.1 - 4.7e-10 39.0 0.6 1.7e-07 30.5 0.6 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 ETS63214.1 - 0.0038 16.3 0.5 0.0073 15.4 0.5 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 ETS63214.1 - 0.04 13.4 0.1 0.07 12.6 0.1 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein TMP-TENI PF02581.17 ETS63214.1 - 0.048 13.0 0.1 0.091 12.1 0.1 1.4 1 0 0 1 1 1 0 Thiamine monophosphate synthase DUF3040 PF11239.8 ETS63214.1 - 4.2 7.7 5.5 1.4 9.2 0.1 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) NrsF PF06532.11 ETS63214.1 - 8.2 6.1 14.7 0.019 14.7 2.5 2.6 4 0 0 4 4 4 0 Negative regulator of sigma F F-box-like PF12937.7 ETS63215.1 - 1.4e-11 44.1 1.5 6e-11 42.1 1.5 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETS63215.1 - 0.0032 17.3 0.1 0.023 14.6 0.2 2.3 2 0 0 2 2 2 1 F-box domain MFS_1 PF07690.16 ETS63216.1 - 1.3e-41 142.8 34.1 1.3e-41 142.8 34.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63216.1 - 3.7e-12 45.9 10.9 3.7e-12 45.9 10.9 2.8 1 1 1 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 ETS63216.1 - 1.1e-11 44.0 1.4 1.7e-11 43.3 1.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_4 PF06779.14 ETS63216.1 - 5.4e-09 35.8 3.2 1.1e-08 34.9 3.2 1.4 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB DUF3611 PF12263.8 ETS63216.1 - 0.27 11.1 0.0 0.27 11.1 0.0 3.6 3 1 0 4 4 4 0 Protein of unknown function (DUF3611) DUF4042 PF13251.6 ETS63218.1 - 4.9e-13 49.2 11.9 1.9e-09 37.5 0.3 5.7 6 1 1 7 7 7 2 Domain of unknown function (DUF4042) HEAT PF02985.22 ETS63218.1 - 0.0023 18.1 21.1 0.12 12.7 0.1 7.5 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 ETS63218.1 - 0.0067 16.8 28.7 0.3 11.5 0.2 8.1 8 0 0 8 8 8 2 HEAT repeats Cnd1 PF12717.7 ETS63218.1 - 0.007 16.4 0.5 12 5.9 0.1 4.3 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 AraC_N PF06719.13 ETS63218.1 - 0.088 12.5 3.8 2.8 7.6 0.3 3.6 2 1 1 3 3 3 0 AraC-type transcriptional regulator N-terminus Uso1_p115_head PF04869.14 ETS63218.1 - 0.18 10.9 0.8 2.6 7.1 0.0 2.7 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, head region Cohesin_HEAT PF12765.7 ETS63218.1 - 0.49 10.8 4.4 1.5 9.2 0.6 3.1 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Arm PF00514.23 ETS63218.1 - 3.6 7.8 5.2 1.2e+02 2.9 0.2 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Pterin_4a PF01329.19 ETS63219.1 - 5.8e-28 96.9 0.2 7.6e-28 96.5 0.2 1.2 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase GST_C_6 PF17171.4 ETS63220.1 - 0.00081 19.1 0.1 0.0033 17.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain DUF3325 PF11804.8 ETS63220.1 - 0.13 12.4 0.2 0.13 12.4 0.2 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3325) Sulfate_transp PF00916.20 ETS63220.1 - 0.14 10.8 0.2 0.2 10.4 0.2 1.2 1 0 0 1 1 1 0 Sulfate permease family LRR_6 PF13516.6 ETS63221.1 - 0.0004 20.2 6.1 2.9 8.2 0.0 5.6 5 0 0 5 5 5 2 Leucine Rich repeat LRR_4 PF12799.7 ETS63221.1 - 0.026 15.0 10.2 0.55 10.7 0.2 4.3 5 1 2 7 7 7 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ETS63221.1 - 0.085 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 F-box-like LRR_1 PF00560.33 ETS63221.1 - 0.093 13.3 4.7 29 5.7 0.0 5.4 3 2 1 4 4 4 0 Leucine Rich Repeat Hydrolase_4 PF12146.8 ETS63222.1 - 8.9e-14 51.3 2.6 6e-12 45.4 0.4 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS63222.1 - 1.5e-10 42.1 5.4 3e-10 41.1 5.4 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETS63222.1 - 3.2e-10 40.1 0.2 2.7e-09 37.1 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 ETS63222.1 - 7.2e-10 39.1 0.6 1.2e-09 38.4 0.6 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 ETS63222.1 - 3.8e-07 30.0 0.1 6e-07 29.3 0.1 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETS63222.1 - 0.00016 21.2 1.6 0.0018 17.8 1.0 2.6 1 1 1 2 2 2 1 Prolyl oligopeptidase family COesterase PF00135.28 ETS63222.1 - 0.00069 18.6 0.1 0.00093 18.2 0.1 1.1 1 0 0 1 1 1 1 Carboxylesterase family BAAT_C PF08840.11 ETS63222.1 - 0.0013 18.7 0.0 0.0029 17.6 0.0 1.6 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase PF00151.19 ETS63222.1 - 0.0045 16.3 0.0 0.0061 15.9 0.0 1.1 1 0 0 1 1 1 1 Lipase DUF818 PF05677.12 ETS63222.1 - 0.029 13.4 0.0 0.051 12.5 0.0 1.3 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Lipase_3 PF01764.25 ETS63222.1 - 0.035 14.0 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) DLH PF01738.18 ETS63222.1 - 0.068 12.7 0.0 1.1 8.7 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 ETS63222.1 - 0.12 12.1 0.0 2.4 7.9 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase HMGL-like PF00682.19 ETS63223.1 - 8.8e-45 153.3 0.0 1.3e-44 152.8 0.0 1.2 1 0 0 1 1 1 1 HMGL-like PGG PF13962.6 ETS63223.1 - 0.078 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF3074 PF11274.8 ETS63224.1 - 5e-45 153.7 0.2 8e-45 153.1 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3074) SUIM_assoc PF16619.5 ETS63225.1 - 0.22 11.6 5.9 1.4 9.1 5.9 2.3 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Ham1p_like PF01725.16 ETS63227.1 - 2.1e-53 181.0 0.0 2.4e-53 180.9 0.0 1.0 1 0 0 1 1 1 1 Ham1 family MFS_1 PF07690.16 ETS63228.1 - 3.7e-28 98.5 23.6 4.6e-28 98.1 23.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3292 PF11696.8 ETS63230.1 - 0.0001 20.9 0.5 0.0001 20.9 0.5 3.7 5 0 0 5 5 5 2 Protein of unknown function (DUF3292) PRT_C PF08372.10 ETS63230.1 - 0.00016 21.4 0.3 0.72 9.6 0.0 2.5 2 0 0 2 2 2 2 Plant phosphoribosyltransferase C-terminal Reticulon PF02453.17 ETS63230.1 - 0.0051 16.8 2.8 2.1 8.3 1.0 2.3 2 0 0 2 2 2 2 Reticulon AAA_18 PF13238.6 ETS63230.1 - 0.01 16.4 0.0 0.036 14.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 ETS63230.1 - 0.025 13.6 0.0 0.044 12.8 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ETS63230.1 - 0.029 14.5 0.2 0.99 9.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ETS63230.1 - 0.044 13.0 0.0 0.085 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 ETS63230.1 - 0.073 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Methyltransf_31 PF13847.6 ETS63231.1 - 3.2e-05 23.8 0.0 0.37 10.6 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.6 ETS63231.1 - 0.00043 20.1 0.0 0.0011 18.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63231.1 - 0.0098 16.6 0.4 7.2 7.4 0.1 3.1 2 2 0 2 2 2 2 Methyltransferase domain Rhodanese PF00581.20 ETS63231.1 - 0.053 14.0 0.0 0.11 13.0 0.0 1.5 1 0 0 1 1 1 0 Rhodanese-like domain PRK PF00485.18 ETS63232.1 - 4.5e-53 179.9 0.0 8.6e-53 179.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 ETS63232.1 - 6.4e-45 153.2 0.1 9.5e-43 146.1 0.0 2.2 2 0 0 2 2 2 2 Uracil phosphoribosyltransferase AAA_18 PF13238.6 ETS63232.1 - 4e-06 27.4 0.0 7.3e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 ETS63232.1 - 0.0001 22.0 0.1 0.00024 20.8 0.0 1.6 2 0 0 2 2 2 1 Dephospho-CoA kinase AAA_33 PF13671.6 ETS63232.1 - 0.00017 21.8 0.0 0.00051 20.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 ETS63232.1 - 0.0005 20.0 0.0 0.00099 19.0 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 ETS63232.1 - 0.07 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Pkinase_fungal PF17667.1 ETS63232.1 - 0.083 11.7 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase AAA_28 PF13521.6 ETS63232.1 - 0.15 12.3 0.0 0.42 10.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain Cyt-b5 PF00173.28 ETS63233.1 - 7.4e-12 45.2 0.0 1.2e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain hSac2 PF12456.8 ETS63234.1 - 4.8e-27 94.0 0.0 9.4e-27 93.0 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase DUF667 PF05018.13 ETS63234.1 - 9.6e-09 35.2 0.0 1.1e-06 28.5 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF667) DUF3179 PF11376.8 ETS63234.1 - 0.0023 17.4 0.0 0.0043 16.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3179) Syja_N PF02383.18 ETS63235.1 - 7.3e-90 301.5 0.0 1.3e-89 300.7 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain Polysacc_deac_1 PF01522.21 ETS63236.1 - 1.7e-29 102.2 0.0 2.8e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Tma16 PF11176.8 ETS63237.1 - 1.2e-39 135.6 0.0 1.2e-39 135.6 0.0 2.3 3 0 0 3 3 3 1 Translation machinery-associated protein 16 RTA1 PF04479.13 ETS63238.1 - 8.7e-42 143.1 10.8 1e-32 113.4 4.7 2.8 3 0 0 3 3 3 2 RTA1 like protein DUF350 PF03994.14 ETS63238.1 - 0.012 15.7 2.0 0.012 15.7 2.0 3.2 3 1 0 3 3 3 0 Domain of Unknown Function (DUF350) Zn_clus PF00172.18 ETS63239.1 - 0.0037 17.4 7.7 0.0081 16.3 7.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain YjcB PF15940.5 ETS63239.1 - 0.047 13.9 0.1 0.096 12.9 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function Patatin PF01734.22 ETS63239.1 - 0.073 13.2 0.3 0.16 12.2 0.3 1.6 1 0 0 1 1 1 0 Patatin-like phospholipase GMC_oxred_N PF00732.19 ETS63240.1 - 7.3e-42 143.7 0.1 1.3e-41 142.9 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS63240.1 - 3e-22 79.7 0.0 1.9e-21 77.1 0.0 2.3 2 1 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ETS63240.1 - 2.9e-06 26.6 3.0 0.028 13.5 1.0 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_binding_3 PF01494.19 ETS63240.1 - 9.6e-05 21.8 0.4 0.00015 21.1 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS63240.1 - 0.013 14.7 0.6 0.056 12.7 0.2 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS63240.1 - 0.033 14.4 1.5 0.09 13.0 1.5 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETS63240.1 - 0.076 12.6 4.0 0.69 9.4 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase MatE PF01554.18 ETS63241.1 - 1.2e-54 184.3 26.3 7.5e-29 100.5 8.7 2.4 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ETS63241.1 - 1.1e-05 25.6 10.7 1.1e-05 25.6 10.7 3.7 3 2 1 4 4 4 2 Polysaccharide biosynthesis C-terminal domain Acetyltransf_1 PF00583.25 ETS63242.1 - 4e-13 49.6 0.0 4.9e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS63242.1 - 1.7e-11 44.4 0.0 3e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS63242.1 - 3.3e-10 40.0 0.0 3.8e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ETS63242.1 - 0.00032 21.4 0.0 0.00039 21.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ETS63242.1 - 0.0011 19.2 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Amidohydro_2 PF04909.14 ETS63243.1 - 6.3e-38 131.2 2.4 6.3e-38 131.2 2.4 1.9 2 0 0 2 2 2 1 Amidohydrolase MFS_1 PF07690.16 ETS63245.1 - 1.3e-30 106.5 28.4 6.4e-30 104.3 29.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Abhydrolase_6 PF12697.7 ETS63245.1 - 1.1e-24 88.3 4.4 3.1e-24 86.8 4.4 1.8 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS63245.1 - 1.4e-09 37.6 0.2 2.7e-09 36.6 0.2 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ETS63245.1 - 7.3e-05 23.0 0.1 0.00024 21.3 0.1 1.8 2 0 0 2 2 2 1 Thioesterase domain Abhydrolase_1 PF00561.20 ETS63245.1 - 0.009 15.7 0.1 0.055 13.1 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 ETS63245.1 - 0.021 14.5 0.1 0.038 13.7 0.1 1.3 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 ETS63245.1 - 0.039 13.8 0.1 0.086 12.7 0.1 1.5 1 0 0 1 1 1 0 Lipase (class 3) DUF900 PF05990.12 ETS63245.1 - 0.052 13.0 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Chlorophyllase2 PF12740.7 ETS63245.1 - 0.11 11.4 0.2 0.33 9.8 0.1 1.8 2 0 0 2 2 2 0 Chlorophyllase enzyme Sugar_tr PF00083.24 ETS63246.1 - 5.4e-50 170.6 16.3 7.6e-50 170.1 16.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter Abhydrolase_3 PF07859.13 ETS63246.1 - 2.9e-34 118.8 0.1 4.6e-34 118.1 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold MFS_1 PF07690.16 ETS63246.1 - 1e-24 87.2 26.3 7.5e-13 48.1 11.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ETS63246.1 - 0.0014 18.0 6.4 0.0015 17.9 3.4 2.1 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB DLH PF01738.18 ETS63246.1 - 0.0023 17.5 0.0 0.0051 16.4 0.0 1.5 1 0 0 1 1 1 1 Dienelactone hydrolase family TPMT PF05724.11 ETS63249.1 - 6.6e-27 94.6 0.0 8.2e-23 81.2 0.0 2.1 1 1 1 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Methyltransf_31 PF13847.6 ETS63249.1 - 7.8e-07 29.0 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63249.1 - 8.7e-07 29.6 0.0 1.4e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS63249.1 - 2.3e-06 28.2 0.0 4.6e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS63249.1 - 0.00031 21.4 0.0 0.00054 20.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS63249.1 - 0.00058 19.7 0.0 0.00084 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETS63249.1 - 0.15 12.0 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Glyco_hydro_92 PF07971.12 ETS63250.1 - 2.9e-113 379.2 0.0 3.9e-113 378.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 ETS63250.1 - 6.4e-40 137.5 0.0 9.6e-40 137.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain DUF2540 PF10802.8 ETS63251.1 - 0.00062 19.8 0.7 0.0012 18.8 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2540) ANAPC_CDC26 PF10471.9 ETS63251.1 - 0.66 10.9 4.9 1.2 10.0 4.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Oxidored_FMN PF00724.20 ETS63254.1 - 1.4e-37 129.8 0.0 2e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Acetyltransf_1 PF00583.25 ETS63255.1 - 0.0014 18.9 0.0 0.0023 18.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS63255.1 - 0.0036 17.7 0.0 0.0064 16.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS63255.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein adh_short PF00106.25 ETS63256.1 - 8.9e-39 133.0 0.1 1.2e-38 132.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63256.1 - 1.6e-26 93.3 0.1 2.1e-26 92.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63256.1 - 1.1e-11 45.0 1.6 1.7e-11 44.4 1.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS63256.1 - 0.035 13.6 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS63256.1 - 0.084 12.3 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 2-Hacid_dh_C PF02826.19 ETS63256.1 - 0.098 12.0 0.2 0.27 10.6 0.1 1.7 1 1 1 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glutaredoxin PF00462.24 ETS63256.1 - 0.18 12.1 0.0 2.1 8.7 0.0 2.5 3 0 0 3 3 3 0 Glutaredoxin Polysacc_synt_2 PF02719.15 ETS63256.1 - 0.19 10.8 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein LOR PF04525.12 ETS63258.1 - 8.2e-18 64.7 0.0 9.9e-18 64.4 0.0 1.0 1 0 0 1 1 1 1 LURP-one-related DUF1295 PF06966.12 ETS63259.1 - 1.4e-51 175.3 0.2 2.1e-51 174.7 0.1 1.4 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ETS63259.1 - 5.4e-06 26.7 0.0 2.3e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Steroid_dh PF02544.16 ETS63259.1 - 8.1e-05 22.6 0.1 0.00019 21.4 0.0 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 ETS63259.1 - 0.013 15.9 0.6 0.041 14.3 0.0 2.1 2 0 0 2 2 2 0 Phospholipid methyltransferase Choline_transpo PF04515.12 ETS63260.1 - 1e-71 241.8 29.3 1e-71 241.8 29.3 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter AMP-binding PF00501.28 ETS63261.1 - 1.5e-66 224.8 0.0 2.5e-64 217.4 0.0 2.5 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ETS63261.1 - 4.4e-06 27.6 0.0 2.7e-05 25.1 0.0 2.4 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain TetR_C_11 PF16859.5 ETS63261.1 - 0.0039 17.5 1.7 0.0081 16.5 0.2 2.3 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain DnaJ_C PF01556.18 ETS63263.1 - 3.1e-24 85.7 0.0 5e-24 85.1 0.0 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ETS63263.1 - 1e-20 73.6 4.1 2.1e-20 72.6 4.1 1.6 1 0 0 1 1 1 1 DnaJ domain Fungal_trans_2 PF11951.8 ETS63263.1 - 5.6e-18 64.9 1.0 7.8e-17 61.1 0.2 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain DnaJ_CXXCXGXG PF00684.19 ETS63263.1 - 6.3e-14 52.1 13.8 6.3e-14 52.1 13.8 2.2 2 0 0 2 2 2 1 DnaJ central domain Zn_clus PF00172.18 ETS63263.1 - 1.1e-05 25.5 12.3 1.1e-05 25.5 12.3 2.9 3 0 0 3 3 3 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Anti-TRAP PF15777.5 ETS63263.1 - 0.0031 17.4 7.7 0.4 10.7 1.2 2.5 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein A2L_zn_ribbon PF08792.10 ETS63263.1 - 0.056 13.2 0.1 0.056 13.2 0.1 3.1 4 0 0 4 4 4 0 A2L zinc ribbon domain BLM10_N PF16547.5 ETS63263.1 - 0.13 12.5 0.1 0.43 10.9 0.1 1.8 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal Indigoidine_A PF04227.12 ETS63264.1 - 2.1e-113 378.5 0.3 3.1e-113 378.0 0.3 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 ETS63264.1 - 7.3e-22 78.0 0.9 1.3e-20 74.0 0.9 2.2 1 1 0 1 1 1 1 pfkB family carbohydrate kinase CEP63 PF17045.5 ETS63264.1 - 0.2 11.5 0.6 0.31 10.9 0.6 1.1 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa AP_endonuc_2 PF01261.24 ETS63265.1 - 2.8e-19 69.4 0.0 8.1e-15 54.8 0.0 2.7 2 1 0 2 2 2 2 Xylose isomerase-like TIM barrel Glyoxalase PF00903.25 ETS63267.1 - 0.00094 19.4 0.0 0.0083 16.3 0.0 2.4 2 1 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ETS63267.1 - 0.0047 16.9 0.0 0.33 10.9 0.0 2.7 2 1 1 3 3 3 1 Glyoxalase-like domain Sun2_CC2 PF18580.1 ETS63267.1 - 0.014 15.6 0.0 0.033 14.4 0.0 1.6 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 AFG1_ATPase PF03969.16 ETS63268.1 - 6.8e-91 304.9 0.0 1.3e-88 297.4 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 ETS63268.1 - 2.3e-07 31.3 0.0 7.1e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETS63268.1 - 1.6e-05 25.2 0.0 0.00013 22.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETS63268.1 - 0.0021 18.5 0.1 0.011 16.1 0.1 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ETS63268.1 - 0.074 13.5 0.0 0.59 10.6 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 ETS63268.1 - 0.13 11.7 0.0 0.28 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region GDPD PF03009.17 ETS63270.1 - 1.2e-30 107.2 0.0 2e-30 106.4 0.0 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ETS63270.1 - 0.0049 17.3 0.6 0.0049 17.3 0.6 2.8 4 0 0 4 4 4 1 Glycerophosphoryl diester phosphodiesterase family p450 PF00067.22 ETS63271.1 - 1.6e-82 277.7 0.0 1.9e-82 277.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 BtrH_N PF14399.6 ETS63271.1 - 0.036 14.3 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Butirosin biosynthesis protein H, N-terminal HlyIII PF03006.20 ETS63272.1 - 2.9e-50 171.1 14.0 3.8e-50 170.7 14.0 1.2 1 0 0 1 1 1 1 Haemolysin-III related PTPLA PF04387.14 ETS63273.1 - 4e-54 182.8 6.8 4e-54 182.8 6.8 1.7 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA Acyl-CoA_dh_1 PF00441.24 ETS63273.1 - 0.028 14.6 0.1 0.041 14.1 0.1 1.2 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain SQS_PSY PF00494.19 ETS63274.1 - 1.5e-57 195.2 0.3 2e-57 194.7 0.3 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase TPPII_N PF12583.8 ETS63274.1 - 3.6 8.2 6.7 25 5.5 0.0 2.2 1 1 1 2 2 2 0 Tripeptidyl peptidase II N terminal Pre-PUA PF17832.1 ETS63275.1 - 5.1e-25 88.0 0.1 1.3e-24 86.7 0.0 1.7 2 0 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 ETS63275.1 - 1.4e-20 73.0 0.3 8.6e-20 70.5 0.2 2.0 2 0 0 2 2 2 1 PUA domain AAA_16 PF13191.6 ETS63276.1 - 0.00011 22.6 0.5 0.0081 16.6 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ETS63276.1 - 0.02 15.2 0.2 0.056 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain PaaA_PaaC PF05138.12 ETS63276.1 - 0.074 12.2 0.1 0.15 11.2 0.1 1.4 1 0 0 1 1 1 0 Phenylacetic acid catabolic protein Cwf_Cwc_15 PF04889.12 ETS63276.1 - 0.09 12.5 3.4 0.19 11.4 3.4 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sporozoite_P67 PF05642.11 ETS63276.1 - 3.9 5.5 6.8 6.7 4.7 4.8 1.9 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF4611 PF15387.6 ETS63276.1 - 8.4 6.7 8.1 4.9 7.4 4.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 ETS63276.1 - 9.3 5.5 7.6 20 4.4 7.6 1.5 1 0 0 1 1 1 0 NOA36 protein Amidase PF01425.21 ETS63277.1 - 4.8e-94 315.9 0.0 8.3e-94 315.1 0.0 1.4 1 1 0 1 1 1 1 Amidase DNA_pol_A_exoN PF18305.1 ETS63277.1 - 0.078 13.3 0.8 0.53 10.6 0.8 2.3 1 1 0 1 1 1 0 3' to 5' exonuclease C-terminal domain zf-DNL PF05180.12 ETS63278.1 - 3.9e-30 103.6 0.3 6e-30 103.0 0.3 1.3 1 0 0 1 1 1 1 DNL zinc finger Ogr_Delta PF04606.12 ETS63278.1 - 1.7 8.7 4.9 1.5 8.8 0.1 2.9 3 0 0 3 3 3 0 Ogr/Delta-like zinc finger MIOX PF05153.15 ETS63279.1 - 2.1e-119 397.7 0.3 2.6e-119 397.3 0.3 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 ETS63279.1 - 0.0063 16.7 0.5 1.7 8.8 0.0 2.7 3 0 0 3 3 3 2 HD domain DUF2138 PF09909.9 ETS63280.1 - 0.11 10.8 0.0 0.14 10.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2138) Pro_dh PF01619.18 ETS63281.1 - 1.6e-48 165.8 0.0 8e-23 81.4 0.0 3.1 2 1 1 3 3 3 3 Proline dehydrogenase PQ-loop PF04193.14 ETS63282.1 - 3.3e-16 58.8 22.4 9.1e-09 35.0 6.0 3.6 4 0 0 4 4 4 2 PQ loop repeat DUF2207 PF09972.9 ETS63282.1 - 0.0065 15.3 0.1 0.021 13.6 0.0 1.9 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) SPX PF03105.19 ETS63282.1 - 1.8 8.4 10.1 2.9 7.7 10.1 1.3 1 0 0 1 1 1 0 SPX domain Syndecan PF01034.20 ETS63282.1 - 1.8 8.5 4.5 15 5.6 0.2 2.7 2 0 0 2 2 2 0 Syndecan domain DUF1387 PF07139.11 ETS63282.1 - 2.6 7.7 7.0 3.7 7.2 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Zn_clus PF00172.18 ETS63284.1 - 5.2e-05 23.3 7.3 8.9e-05 22.5 7.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS63284.1 - 0.00017 20.7 3.1 0.0028 16.7 0.2 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain BPS1 PF05633.11 ETS63284.1 - 0.19 10.7 2.1 0.48 9.4 2.1 1.7 1 0 0 1 1 1 0 Protein BYPASS1-related DUF281 PF03436.13 ETS63284.1 - 3.4 8.1 5.5 31 5.1 0.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF281) MFS_1 PF07690.16 ETS63285.1 - 3.4e-37 128.2 47.2 3.4e-37 128.2 47.2 1.6 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63285.1 - 2.7e-09 36.4 11.1 2.7e-09 36.4 11.1 2.2 2 1 0 2 2 2 1 Sugar (and other) transporter Sdh5 PF03937.16 ETS63286.1 - 8.2e-27 93.0 0.4 1.3e-26 92.4 0.4 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase MSA-2c PF12238.8 ETS63286.1 - 3.3 7.7 6.6 5.1 7.0 6.6 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Pyr_redox_2 PF07992.14 ETS63288.1 - 2.5e-49 168.1 7.4 3.5e-49 167.6 7.4 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 ETS63288.1 - 1.8e-15 56.7 0.0 3.7e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 ETS63288.1 - 4e-12 46.5 10.4 1.3e-10 41.7 1.5 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS63288.1 - 1.9e-11 43.8 1.1 6.5e-06 25.6 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETS63288.1 - 2.5e-05 23.6 0.8 0.29 10.2 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Reductase_C PF14759.6 ETS63288.1 - 0.00032 21.2 0.0 0.0084 16.6 0.0 2.6 2 0 0 2 2 2 1 Reductase C-terminal GIDA PF01134.22 ETS63288.1 - 0.0015 17.7 1.2 0.036 13.1 0.1 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A Rieske_2 PF13806.6 ETS63288.1 - 0.012 15.5 0.0 0.049 13.6 0.0 2.1 2 0 0 2 2 2 0 Rieske-like [2Fe-2S] domain NAD_binding_7 PF13241.6 ETS63288.1 - 0.023 15.1 5.4 0.27 11.7 0.3 2.9 3 0 0 3 3 3 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 ETS63288.1 - 0.035 14.3 0.5 3.6 7.9 0.2 2.5 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ETS63288.1 - 0.036 14.0 2.6 0.3 11.0 0.1 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding Eno-Rase_NADH_b PF12242.8 ETS63288.1 - 0.079 12.7 0.1 0.31 10.8 0.1 2.0 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF1188 PF06690.11 ETS63288.1 - 0.1 12.1 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1188) TrkA_N PF02254.18 ETS63288.1 - 0.46 10.8 3.4 5 7.4 0.4 2.6 2 0 0 2 2 2 0 TrkA-N domain FAD_binding_2 PF00890.24 ETS63288.1 - 0.62 9.1 8.5 7.1 5.6 0.5 3.5 3 1 1 4 4 4 0 FAD binding domain TAL_FSA PF00923.19 ETS63289.1 - 5.9e-45 153.8 0.2 9.2e-45 153.2 0.2 1.3 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Imm49 PF15575.6 ETS63289.1 - 0.0089 15.8 2.0 0.15 11.8 0.1 2.4 2 0 0 2 2 2 2 Immunity protein 49 DUF2635 PF10948.8 ETS63290.1 - 0.13 12.0 0.1 0.29 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2635) PolC_DP2 PF03833.13 ETS63290.1 - 0.32 8.8 0.8 0.43 8.4 0.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DnaJ PF00226.31 ETS63291.1 - 1.9e-15 56.7 1.7 3.9e-15 55.7 1.7 1.6 1 0 0 1 1 1 1 DnaJ domain DUF2924 PF11149.8 ETS63291.1 - 1.3 9.5 5.6 0.53 10.7 3.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2924) SDH_alpha PF03313.15 ETS63292.1 - 1.7e-95 319.6 0.2 2.6e-95 319.0 0.2 1.3 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 ETS63292.1 - 6.6e-54 182.5 0.1 1.8e-53 181.1 0.0 1.7 2 0 0 2 2 2 1 Serine dehydratase beta chain zf-rbx1 PF12678.7 ETS63292.1 - 0.00035 20.8 4.4 0.00081 19.6 4.4 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETS63292.1 - 0.0012 18.7 3.3 0.0026 17.6 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS63292.1 - 0.0048 17.2 5.6 0.0048 17.2 5.6 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETS63292.1 - 0.12 12.4 4.0 0.24 11.4 4.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS63292.1 - 0.14 12.0 9.1 0.1 12.5 4.6 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ETS63292.1 - 0.28 11.4 2.7 12 6.2 2.7 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-ANAPC11 PF12861.7 ETS63292.1 - 1.1 9.4 3.7 1.1 9.3 1.6 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETS63292.1 - 4 7.1 5.1 11 5.7 5.1 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Zn_clus PF00172.18 ETS63293.1 - 0.0042 17.2 7.0 0.0076 16.3 7.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UBZ_FAAP20 PF15750.5 ETS63293.1 - 1.3 9.0 5.3 17 5.4 0.3 2.5 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Acetyltransf_8 PF13523.6 ETS63294.1 - 1.1e-35 122.5 0.2 1.8e-35 121.7 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ADH_zinc_N PF00107.26 ETS63295.1 - 5.7e-31 107.2 0.8 8.5e-31 106.6 0.8 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS63295.1 - 1.1e-11 45.9 0.0 1.7e-11 45.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS63295.1 - 9.3e-05 22.3 0.0 0.00023 21.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 ETS63295.1 - 0.00061 19.2 0.9 0.00096 18.5 0.9 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Oxidored_FMN PF00724.20 ETS63296.1 - 1.4e-53 182.3 0.0 4.8e-53 180.6 0.0 1.7 1 1 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DUF2034 PF10356.9 ETS63297.1 - 7.9e-15 54.8 0.5 3.4e-09 36.4 0.1 3.1 2 1 1 3 3 3 3 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 ETS63297.1 - 6.2e-07 29.4 0.0 5.4e-05 23.2 0.0 2.2 2 0 0 2 2 2 2 Restriction endonuclease TPR_11 PF13414.6 ETS63298.1 - 1.4e-18 66.3 8.8 6.6e-06 25.7 0.2 4.5 3 1 1 4 4 4 4 TPR repeat TPR_1 PF00515.28 ETS63298.1 - 1.5e-18 65.7 6.4 2.9e-06 26.9 0.1 4.7 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETS63298.1 - 1.4e-17 62.3 7.8 7.9e-07 28.7 0.1 4.8 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETS63298.1 - 3.9e-13 49.5 9.4 6.6e-05 23.1 0.1 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETS63298.1 - 6.6e-13 49.1 4.7 1.9e-07 31.6 0.2 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETS63298.1 - 5.2e-11 42.9 7.1 4.1e-05 24.0 0.5 3.1 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETS63298.1 - 7e-11 42.0 9.0 0.005 17.6 0.1 4.8 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETS63298.1 - 1.1e-10 40.9 4.5 0.015 15.4 0.1 4.7 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETS63298.1 - 1.3e-10 40.9 4.9 0.046 14.1 0.1 4.9 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETS63298.1 - 1.1e-06 28.2 7.0 0.8 9.9 0.2 4.4 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETS63298.1 - 1.4e-06 28.6 3.2 0.024 15.3 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETS63298.1 - 2.8e-05 23.5 3.0 3e-05 23.4 2.0 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETS63298.1 - 4.3e-05 23.6 1.0 0.007 16.5 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS63298.1 - 9.2e-05 22.6 2.8 0.043 14.0 0.8 2.9 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETS63298.1 - 0.0037 17.6 5.6 0.018 15.4 0.3 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETS63298.1 - 0.018 14.9 10.0 1.2 9.1 1.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat HSCB_C PF07743.13 ETS63298.1 - 1.1 9.8 6.1 0.54 10.8 1.1 2.6 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain DUF3767 PF12597.8 ETS63299.1 - 4.3e-25 87.5 0.2 5.6e-25 87.1 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) DUF2076 PF09849.9 ETS63299.1 - 0.1 12.6 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SUR7 PF06687.12 ETS63300.1 - 6.2e-10 39.1 6.7 8.4e-10 38.6 6.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family EphA2_TM PF14575.6 ETS63301.1 - 0.0066 17.3 0.0 0.0091 16.9 0.0 1.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain MacB_PCD PF12704.7 ETS63301.1 - 0.016 15.5 0.0 0.019 15.3 0.0 1.1 1 0 0 1 1 1 0 MacB-like periplasmic core domain DUF347 PF03988.12 ETS63301.1 - 0.017 15.3 0.2 0.034 14.3 0.2 1.5 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) DUF3309 PF11752.8 ETS63301.1 - 0.049 13.7 2.0 0.12 12.5 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3309) DUF2275 PF10039.9 ETS63301.1 - 0.05 13.7 0.0 0.065 13.3 0.0 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2275) SKG6 PF08693.10 ETS63301.1 - 0.088 12.2 5.2 0.15 11.4 5.2 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain ALO PF04030.14 ETS63302.1 - 2.5e-64 217.6 2.7 1e-54 186.1 0.3 3.1 3 0 0 3 3 3 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 ETS63302.1 - 5.8e-19 68.2 0.1 1.1e-18 67.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Yeast-kill-tox PF09207.11 ETS63303.1 - 0.31 11.7 2.9 4.4 8.0 0.2 2.8 3 0 0 3 3 3 0 Yeast killer toxin EI24 PF07264.11 ETS63304.1 - 5e-29 101.8 9.0 7.2e-29 101.3 9.0 1.3 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Aa_trans PF01490.18 ETS63306.1 - 1.3e-52 178.9 39.0 1.5e-52 178.7 39.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein HIG_1_N PF04588.13 ETS63307.1 - 1.3e-16 60.5 0.0 1.9e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region YjbE PF11106.8 ETS63308.1 - 0.48 10.7 8.1 50 4.2 7.9 2.5 2 0 0 2 2 2 0 Exopolysaccharide production protein YjbE MFS_1 PF07690.16 ETS63309.1 - 1.7e-26 93.0 26.7 1.7e-26 93.0 26.7 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 ETS63309.1 - 6.9e-05 22.3 6.0 6.9e-05 22.3 6.0 2.3 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB YcxB PF14317.6 ETS63309.1 - 0.14 11.9 0.1 0.32 10.7 0.1 1.6 1 0 0 1 1 1 0 YcxB-like protein Rhodanese PF00581.20 ETS63310.1 - 2.3e-16 60.2 0.0 1e-08 35.6 0.0 3.2 2 1 0 2 2 2 2 Rhodanese-like domain Polysacc_synt_4 PF04669.13 ETS63310.1 - 0.036 13.6 0.0 0.076 12.6 0.0 1.5 2 0 0 2 2 2 0 Polysaccharide biosynthesis ThiC-associated PF13667.6 ETS63310.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 ThiC-associated domain Sugar_tr PF00083.24 ETS63311.1 - 4.7e-121 404.8 27.2 5.5e-121 404.6 27.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS63311.1 - 3.4e-25 88.7 42.4 1.2e-21 77.0 7.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Imm_superinfect PF14373.6 ETS63311.1 - 0.21 11.6 4.4 13 5.8 0.1 2.8 2 0 0 2 2 2 0 Superinfection immunity protein Phage_holin_3_2 PF04550.12 ETS63311.1 - 0.29 11.7 4.6 7 7.3 2.1 2.8 2 0 0 2 2 2 0 Phage holin family 2 MGC-24 PF05283.11 ETS63312.1 - 0.0066 16.9 7.1 0.0066 16.9 7.1 2.3 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin EphA2_TM PF14575.6 ETS63312.1 - 0.093 13.6 0.0 0.2 12.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Asp PF00026.23 ETS63313.1 - 1.9e-45 155.7 14.1 1e-44 153.2 14.1 1.9 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS63313.1 - 5.9e-06 26.6 9.4 0.022 15.0 0.1 3.6 3 1 1 4 4 4 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS63313.1 - 2e-05 25.1 1.7 0.1 13.2 0.5 2.6 2 0 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ETS63313.1 - 3e-05 24.5 0.4 0.048 14.2 0.1 2.7 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 ETS63313.1 - 0.0027 17.5 0.0 0.0078 16.0 0.0 1.8 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal Ribonuc_L-PSP PF01042.21 ETS63316.1 - 2.2e-38 131.0 0.1 4.2e-38 130.1 0.1 1.5 1 1 0 1 1 1 1 Endoribonuclease L-PSP SET PF00856.28 ETS63318.1 - 0.0012 19.3 0.2 1 9.7 0.0 3.2 1 1 1 2 2 2 1 SET domain CTU2 PF10288.9 ETS63318.1 - 0.95 9.7 5.8 0.15 12.3 1.2 2.0 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 SDA1 PF05285.12 ETS63318.1 - 1.2 8.4 19.3 2.2 7.6 19.3 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETS63318.1 - 4.4 5.5 11.6 7.1 4.8 11.6 1.3 1 0 0 1 1 1 0 CDC45-like protein zf-UBR PF02207.20 ETS63319.1 - 1.2e-16 60.7 15.4 1.2e-16 60.7 15.4 2.2 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 ETS63319.1 - 6.7e-09 35.4 0.0 1.8e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS UBA_4 PF14555.6 ETS63319.1 - 0.035 13.9 0.1 0.099 12.5 0.1 1.7 1 0 0 1 1 1 0 UBA-like domain Fungal_trans PF04082.18 ETS63320.1 - 1.3e-12 47.3 0.0 3e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63320.1 - 1.9e-07 31.1 8.8 3.5e-07 30.2 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MAGUK_N_PEST PF10608.9 ETS63320.1 - 0.05 14.0 1.1 0.19 12.2 1.1 2.0 1 0 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK HisKA_3 PF07730.13 ETS63320.1 - 0.4 11.2 5.6 0.13 12.8 0.7 2.7 2 0 0 2 2 2 0 Histidine kinase ICE2 PF08426.10 ETS63321.1 - 1.4e-63 215.5 11.9 8.7e-35 120.6 1.9 4.1 2 2 1 3 3 3 3 ICE2 RXT2_N PF08595.11 ETS63321.1 - 0.64 10.0 1.5 1.2 9.2 1.5 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DS PF01916.17 ETS63322.1 - 9.3e-133 441.9 0.0 1.1e-132 441.6 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase DUF494 PF04361.13 ETS63322.1 - 0.013 15.4 0.0 0.022 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Abhydrolase_5 PF12695.7 ETS63323.1 - 0.0012 18.7 0.2 0.0036 17.1 0.0 1.8 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS63323.1 - 0.035 13.4 0.0 0.076 12.3 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Lipase_3 PF01764.25 ETS63323.1 - 0.036 13.9 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF818 PF05677.12 ETS63323.1 - 0.21 10.5 0.0 0.34 9.8 0.0 1.3 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) EXS PF03124.14 ETS63324.1 - 4e-100 335.3 1.4 4.8e-100 335.1 1.4 1.1 1 0 0 1 1 1 1 EXS family DUF775 PF05603.12 ETS63325.1 - 2.6e-45 154.4 0.0 3.2e-45 154.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Nop16 PF09420.10 ETS63326.1 - 1.2e-56 192.1 0.6 1.4e-56 191.9 0.6 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 Xan_ur_permease PF00860.20 ETS63327.1 - 7.4e-60 202.7 25.9 1.6e-59 201.5 25.9 1.5 1 0 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 ETS63327.1 - 1.7 9.1 23.3 0.067 13.6 2.6 4.5 3 1 1 4 4 4 0 Molybdate transporter of MFS superfamily ATG_C PF09333.11 ETS63328.1 - 0.89 9.9 4.8 1.6 9.1 4.3 1.8 1 1 0 1 1 1 0 Autophagy-related protein C terminal domain C5-epim_C PF06662.13 ETS63329.1 - 0.096 12.2 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 D-glucuronyl C5-epimerase C-terminus Lyase_aromatic PF00221.19 ETS63330.1 - 9.3e-147 489.4 2.3 1.1e-146 489.2 2.3 1.1 1 0 0 1 1 1 1 Aromatic amino acid lyase Epimerase PF01370.21 ETS63331.1 - 1.8e-15 57.1 0.0 2.2e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS63331.1 - 6.9e-11 41.7 0.0 9.4e-11 41.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ETS63331.1 - 9.3e-10 38.4 0.2 7.3e-09 35.5 0.2 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ETS63331.1 - 1.4e-08 34.2 0.0 2e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ETS63331.1 - 4.8e-08 32.5 0.0 0.0014 17.9 0.0 2.5 2 1 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ETS63331.1 - 0.072 12.2 0.0 0.71 8.9 0.0 2.0 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Hydantoinase_B PF02538.14 ETS63332.1 - 1.5e-210 700.0 0.3 1.8e-210 699.8 0.3 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Proteasome_A_N PF10584.9 ETS63332.1 - 0.26 11.0 1.4 0.49 10.1 0.0 2.0 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Sporozoite_P67 PF05642.11 ETS63333.1 - 9.7 4.1 12.9 13 3.7 12.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Herpes_env PF01673.18 ETS63334.1 - 0.15 11.0 7.0 0.33 9.8 7.0 1.5 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein TFIIA PF03153.13 ETS63334.1 - 0.51 10.3 22.7 0.038 14.0 17.3 1.7 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit ARGLU PF15346.6 ETS63334.1 - 0.64 9.9 27.2 1.1 9.1 27.2 1.4 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 DUF572 PF04502.13 ETS63334.1 - 1.8 8.1 21.8 3.2 7.3 21.7 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF572) Form_Nir_trans PF01226.17 ETS63335.1 - 3.1e-63 213.3 20.8 4.7e-63 212.7 20.8 1.3 1 0 0 1 1 1 1 Formate/nitrite transporter HECT PF00632.25 ETS63335.1 - 2.6e-31 109.3 0.0 1.5e-22 80.5 0.0 2.4 2 0 0 2 2 2 2 HECT-domain (ubiquitin-transferase) RRF PF01765.19 ETS63336.1 - 1.7e-38 132.2 0.1 2.7e-38 131.5 0.1 1.3 1 0 0 1 1 1 1 Ribosome recycling factor TRAM_LAG1_CLN8 PF03798.16 ETS63337.1 - 1.7e-30 106.2 11.3 2.2e-30 105.9 11.3 1.1 1 0 0 1 1 1 1 TLC domain CUE PF02845.16 ETS63338.1 - 2.1e-08 33.7 0.8 0.00031 20.4 0.0 4.0 4 0 0 4 4 4 2 CUE domain Smr PF01713.21 ETS63338.1 - 7.6e-07 29.4 1.6 1e-06 29.0 0.1 2.1 2 0 0 2 2 2 1 Smr domain DUF1771 PF08590.10 ETS63338.1 - 0.00085 19.6 5.0 0.00085 19.6 5.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF1771) DMA PF03474.14 ETS63338.1 - 0.0054 16.3 0.0 0.01 15.4 0.0 1.5 1 0 0 1 1 1 1 DMRTA motif Oxidored-like PF09791.9 ETS63339.1 - 1.1e-07 31.3 9.0 3.1e-07 30.0 9.0 1.7 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Abhydrolase_1 PF00561.20 ETS63339.1 - 0.00014 21.6 0.2 0.00065 19.4 0.2 1.9 2 0 0 2 2 2 1 alpha/beta hydrolase fold adh_short_C2 PF13561.6 ETS63341.1 - 1.6e-53 181.7 3.1 2.1e-53 181.3 3.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS63341.1 - 6.1e-44 149.8 0.6 8e-44 149.4 0.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS63341.1 - 1.6e-08 34.7 1.1 3.9e-08 33.4 1.1 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETS63341.1 - 0.0097 15.1 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1657 PF07870.11 ETS63341.1 - 0.11 12.3 0.8 0.21 11.5 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) UPRTase PF14681.6 ETS63342.1 - 1.8e-70 236.6 0.0 2e-70 236.4 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ETS63342.1 - 0.084 12.4 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase domain MFS_1 PF07690.16 ETS63343.1 - 1.1e-20 73.9 45.6 1.3e-14 53.9 24.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63343.1 - 7.9e-16 57.9 23.5 1.8e-15 56.8 7.2 2.4 2 1 0 2 2 2 2 Sugar (and other) transporter DJ-1_PfpI PF01965.24 ETS63344.1 - 1.7e-11 44.2 0.0 3e-11 43.4 0.0 1.5 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ETS63344.1 - 0.00019 21.2 0.0 0.0022 17.7 0.0 2.0 1 1 0 1 1 1 1 ThiJ/PfpI family-like adh_short PF00106.25 ETS63345.1 - 8.7e-41 139.5 0.0 1.1e-40 139.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63345.1 - 2.2e-19 70.0 0.0 2.8e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63345.1 - 5.9e-10 39.3 0.0 8.3e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS63345.1 - 0.00061 19.3 0.0 0.00082 18.9 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ETS63345.1 - 0.013 14.7 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein F420_oxidored PF03807.17 ETS63345.1 - 0.021 15.4 0.0 0.054 14.1 0.0 1.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 ETS63345.1 - 0.037 13.4 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3HCDH_N PF02737.18 ETS63345.1 - 0.062 13.2 0.0 0.15 11.9 0.0 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ATP-synt_ab PF00006.25 ETS63345.1 - 0.12 12.1 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain TrkA_N PF02254.18 ETS63345.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox PF00070.27 ETS63345.1 - 0.15 12.7 0.1 0.31 11.6 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Zip PF02535.22 ETS63346.1 - 5.9e-62 209.8 13.6 7.8e-62 209.4 13.6 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Sigma70_r4_2 PF08281.12 ETS63346.1 - 0.13 12.0 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 GerE PF00196.19 ETS63346.1 - 0.15 11.7 0.1 0.29 10.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, luxR family Sigma70_r4_2 PF08281.12 ETS63347.1 - 1.3e-07 31.2 0.0 2.3e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_38 PF13936.6 ETS63347.1 - 3.7e-06 26.6 0.0 6.8e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4 PF04545.16 ETS63347.1 - 1.9e-05 24.1 0.0 3.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.6 ETS63347.1 - 3.5e-05 23.5 0.1 6.7e-05 22.6 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 ETS63347.1 - 0.00069 19.6 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_32 PF13565.6 ETS63347.1 - 0.0015 19.1 0.1 0.003 18.1 0.1 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_35 PF13693.6 ETS63347.1 - 0.0016 18.4 0.0 0.0044 17.0 0.0 1.7 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding Terminase_5 PF06056.12 ETS63347.1 - 0.0047 16.8 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) GerE PF00196.19 ETS63347.1 - 0.0074 15.8 0.0 0.016 14.8 0.0 1.6 1 1 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_29 PF13551.6 ETS63347.1 - 0.019 15.0 0.3 0.098 12.7 0.0 2.2 1 1 1 2 2 2 0 Winged helix-turn helix DUF3760 PF12586.8 ETS63348.1 - 0.00016 21.8 1.5 0.00039 20.5 1.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) F-box-like PF12937.7 ETS63348.1 - 0.076 12.9 1.8 0.19 11.6 1.8 1.8 1 0 0 1 1 1 0 F-box-like Ytp1 PF10355.9 ETS63349.1 - 2.3e-56 191.1 26.7 2.7e-56 190.8 19.9 2.6 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ETS63349.1 - 3.7e-29 100.6 2.7 3.7e-29 100.6 2.7 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Fungal_trans PF04082.18 ETS63350.1 - 1.3e-17 63.7 0.1 2.8e-17 62.6 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63350.1 - 9e-05 22.5 5.7 9e-05 22.5 5.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 ETS63350.1 - 0.0016 18.8 12.8 0.01 16.3 0.3 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS63350.1 - 0.002 18.8 11.6 0.16 12.9 0.8 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger TerY_C PF15616.6 ETS63350.1 - 0.11 12.6 1.6 0.45 10.6 0.1 2.3 2 0 0 2 2 2 0 TerY-C metal binding domain zf-C2HC_2 PF13913.6 ETS63350.1 - 0.26 11.2 9.9 0.52 10.3 0.2 3.2 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_6 PF13912.6 ETS63350.1 - 1.7 8.8 8.4 1.9 8.6 0.4 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETS63350.1 - 1.7 9.0 5.2 10 6.5 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding C1_1 PF00130.22 ETS63350.1 - 2.8 7.9 6.1 0.17 11.8 0.5 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) MFS_1 PF07690.16 ETS63351.1 - 6.7e-18 64.7 27.3 6.7e-18 64.7 27.3 2.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63351.1 - 1.5e-11 43.8 6.0 1.5e-11 43.8 6.0 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter NnrU PF07298.11 ETS63351.1 - 0.62 9.5 9.3 1.6 8.2 0.2 2.9 3 0 0 3 3 3 0 NnrU protein Peptidase_S15 PF02129.18 ETS63352.1 - 1.3e-34 120.0 0.0 3.3e-33 115.4 0.0 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) PepX_C PF08530.10 ETS63352.1 - 2.4e-33 116.0 0.0 3.3e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Hydrolase_4 PF12146.8 ETS63352.1 - 0.21 10.8 0.0 0.36 10.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF1479 PF07350.12 ETS63353.1 - 3.3e-05 22.8 0.2 0.00038 19.3 0.1 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF1479) PhyH PF05721.13 ETS63353.1 - 0.00016 22.0 0.0 0.0032 17.7 0.0 2.3 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 ETS63353.1 - 0.0016 19.3 0.0 0.0031 18.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ETS63353.1 - 0.0058 17.0 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase TauD PF02668.16 ETS63353.1 - 0.015 15.1 0.2 0.05 13.4 0.0 2.0 2 0 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family CTP_transf_like PF01467.26 ETS63354.1 - 2.6e-23 82.8 0.0 4.5e-23 82.0 0.0 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Tis11B_N PF04553.12 ETS63354.1 - 0.071 13.7 0.5 0.32 11.6 0.5 2.1 1 0 0 1 1 1 0 Tis11B like protein, N terminus MarB PF13999.6 ETS63354.1 - 0.074 12.9 0.9 0.95 9.4 0.3 3.0 3 0 0 3 3 3 0 MarB protein SelP_N PF04592.14 ETS63354.1 - 5.7 6.3 22.0 0.4 10.1 16.6 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region MMtag PF10159.9 ETS63355.1 - 5.4e-28 97.1 1.6 5.4e-28 97.1 1.6 2.5 2 1 0 2 2 2 1 Multiple myeloma tumor-associated DUF1315 PF07023.12 ETS63355.1 - 0.44 10.7 2.3 0.45 10.6 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1315) Med19 PF10278.9 ETS63355.1 - 5.3 6.9 14.7 9.7 6.1 14.7 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CDC45 PF02724.14 ETS63355.1 - 8.9 4.5 18.8 0.5 8.6 13.8 1.4 2 0 0 2 2 2 0 CDC45-like protein IMS PF00817.20 ETS63356.1 - 9.7e-38 129.5 0.0 1.8e-37 128.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ETS63356.1 - 1.1e-06 29.3 0.0 8.5e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 ETS63356.1 - 4.9e-05 22.8 1.6 0.00023 20.7 0.3 2.3 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger Glyco_hydro_cc PF11790.8 ETS63357.1 - 9.3e-69 231.6 4.3 1.1e-68 231.4 4.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_53 PF07745.13 ETS63357.1 - 0.0063 15.5 0.0 0.0096 14.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Glyco_hydro_39 PF01229.17 ETS63357.1 - 0.03 12.9 0.0 0.043 12.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 39 MFS_1 PF07690.16 ETS63358.1 - 3.3e-22 78.9 37.9 6e-13 48.4 18.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Neurensin PF14927.6 ETS63358.1 - 0.95 9.2 4.3 0.71 9.6 0.0 3.0 4 0 0 4 4 4 0 Neurensin DUF2975 PF11188.8 ETS63358.1 - 6.1 6.7 13.8 0.11 12.4 0.7 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2975) Alpha-amylase PF00128.24 ETS63359.1 - 8.9e-68 229.3 0.0 1.4e-67 228.7 0.0 1.3 1 0 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ETS63359.1 - 4.5e-14 52.5 0.4 8.6e-14 51.6 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) hDGE_amylase PF14701.6 ETS63359.1 - 0.23 10.5 1.3 0.34 9.9 1.3 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain PAN_4 PF14295.6 ETS63360.1 - 0.025 14.5 0.1 0.098 12.6 0.1 2.0 1 0 0 1 1 1 0 PAN domain Cu-oxidase_2 PF07731.14 ETS63361.1 - 3.1e-41 140.3 5.9 8.6e-39 132.4 1.1 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ETS63361.1 - 3e-38 131.4 0.1 4.3e-35 121.2 0.1 2.8 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 ETS63361.1 - 6.5e-31 106.8 0.5 2.4e-26 92.1 0.1 3.9 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 ETS63361.1 - 0.17 12.0 0.0 3.4 7.8 0.0 2.8 3 0 0 3 3 3 0 Cupredoxin-like domain FTR1 PF03239.14 ETS63362.1 - 1.9e-53 181.6 7.4 1.8e-35 122.6 4.3 2.1 2 0 0 2 2 2 2 Iron permease FTR1 family LPD15 PF18828.1 ETS63362.1 - 0.22 11.4 0.8 0.53 10.2 0.8 1.6 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 DUF2721 PF11026.8 ETS63362.1 - 0.99 9.3 6.4 0.14 12.1 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) FtsX PF02687.21 ETS63362.1 - 4.4 7.8 9.5 0.99 9.9 0.3 2.9 2 1 0 2 2 2 0 FtsX-like permease family adh_short_C2 PF13561.6 ETS63364.1 - 4.9e-62 209.5 0.2 6.4e-62 209.2 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS63364.1 - 1.1e-46 158.7 0.5 1.7e-46 158.2 0.5 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS63364.1 - 1.7e-14 54.1 0.1 3e-14 53.4 0.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS63364.1 - 0.00015 21.3 0.0 0.00036 20.1 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ETS63364.1 - 0.0082 15.3 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Dak1 PF02733.17 ETS63365.1 - 2.4e-102 342.0 0.0 3.3e-102 341.6 0.0 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 ETS63365.1 - 6.5e-45 153.1 0.7 6.5e-45 153.1 0.7 2.2 2 0 0 2 2 2 1 DAK2 domain DUF1769 PF08588.10 ETS63366.1 - 2.7e-17 62.7 0.4 5.2e-17 61.8 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) Mpv17_PMP22 PF04117.12 ETS63367.1 - 2.4e-05 24.5 5.1 0.00018 21.7 3.3 2.2 1 1 1 2 2 2 1 Mpv17 / PMP22 family MatE PF01554.18 ETS63367.1 - 0.026 14.2 2.9 0.3 10.7 0.2 2.4 1 1 1 2 2 2 0 MatE Prp19 PF08606.11 ETS63368.1 - 8.3e-31 105.8 2.0 1.5e-30 104.9 2.0 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 ETS63368.1 - 1.8e-28 98.2 0.9 0.0022 18.8 0.0 7.8 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63368.1 - 6.1e-17 61.7 0.1 5e-05 23.5 0.0 5.3 3 1 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS63368.1 - 0.017 13.8 0.0 4.2 5.9 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 zf-Nse PF11789.8 ETS63368.1 - 0.045 13.6 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Ge1_WD40 PF16529.5 ETS63368.1 - 0.087 11.8 0.0 16 4.3 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RCC1_2 PF13540.6 ETS63368.1 - 0.36 10.7 1.4 1.2 9.0 0.1 2.6 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat Fungal_trans PF04082.18 ETS63369.1 - 6.1e-29 100.9 0.0 1.2e-28 99.9 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63369.1 - 1.3e-11 44.4 8.8 2.4e-11 43.5 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIID-18kDa PF02269.16 ETS63370.1 - 1.3e-28 98.8 0.7 5.9e-28 96.7 0.3 2.0 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Adaptin_binding PF10199.9 ETS63370.1 - 0.15 12.7 2.3 0.89 10.2 0.2 2.3 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 TFIIE-A_C PF11521.8 ETS63370.1 - 5 7.5 7.3 0.33 11.3 0.3 2.3 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha ADH_zinc_N PF00107.26 ETS63371.1 - 8.3e-11 42.0 0.3 3.3e-09 36.8 0.3 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS63371.1 - 4.8e-07 30.9 0.0 1.2e-06 29.6 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS63371.1 - 0.047 13.6 0.0 0.092 12.6 0.0 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain Aminotran_4 PF01063.19 ETS63372.1 - 2.9e-26 92.7 0.0 8.7e-26 91.2 0.0 1.7 1 1 0 1 1 1 1 Amino-transferase class IV MFS_1 PF07690.16 ETS63373.1 - 1.5e-29 103.0 38.9 1.5e-29 103.0 38.9 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF2530 PF10745.9 ETS63373.1 - 0.4 10.9 6.3 1.6 9.1 0.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) Amidase PF01425.21 ETS63374.1 - 1.1e-85 288.3 0.0 4.1e-83 279.8 0.0 2.1 1 1 0 1 1 1 1 Amidase UDPG_MGDP_dh_N PF03721.14 ETS63375.1 - 5.4e-60 202.2 0.1 1.1e-58 197.9 0.0 2.2 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ETS63375.1 - 2.8e-32 111.3 0.2 1.5e-31 108.9 0.2 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 ETS63375.1 - 1.1e-31 108.8 0.0 2.6e-31 107.7 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.15 ETS63375.1 - 0.014 15.5 0.1 0.58 10.3 0.0 2.5 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Metallophos PF00149.28 ETS63376.1 - 4.3e-08 33.9 0.0 9e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase SpoIIE PF07228.12 ETS63377.1 - 2e-13 50.7 0.0 3e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ETS63377.1 - 0.00035 20.3 1.2 0.00048 19.8 0.1 1.9 2 1 0 2 2 2 1 Protein phosphatase 2C PP2C PF00481.21 ETS63377.1 - 0.0005 19.8 0.0 0.048 13.3 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C DUF1770 PF08589.10 ETS63378.1 - 1.1e-08 36.0 0.7 3.2e-07 31.2 0.5 2.1 1 1 1 2 2 2 1 Fungal protein of unknown function (DUF1770) AidB_N PF18158.1 ETS63379.1 - 6.7e-18 65.1 0.0 2.3e-17 63.4 0.0 1.8 2 0 0 2 2 2 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_1 PF00441.24 ETS63379.1 - 5.2e-15 55.9 0.2 5.2e-15 55.9 0.2 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS63379.1 - 2.7e-14 53.1 0.0 4.9e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ETS63379.1 - 0.0097 16.6 0.1 0.66 10.7 0.0 3.0 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain FMN_dh PF01070.18 ETS63380.1 - 3.9e-119 397.8 0.1 4.9e-119 397.4 0.1 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ETS63380.1 - 1.9e-17 63.1 0.0 3.6e-17 62.3 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ETS63380.1 - 1.9e-05 24.0 0.0 3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ETS63380.1 - 0.0003 19.9 0.2 0.0011 18.1 0.2 1.9 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain A_deaminase_N PF08451.11 ETS63380.1 - 0.0069 16.7 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Adenosine/AMP deaminase N-terminal Peripla_BP_4 PF13407.6 ETS63380.1 - 0.022 14.3 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 Periplasmic binding protein domain His_biosynth PF00977.21 ETS63380.1 - 0.033 13.7 0.0 9.9 5.5 0.0 2.8 4 0 0 4 4 4 0 Histidine biosynthesis protein NMO PF03060.15 ETS63380.1 - 0.042 13.2 0.0 0.079 12.3 0.0 1.4 1 0 0 1 1 1 0 Nitronate monooxygenase Usp PF00582.26 ETS63382.1 - 5.4e-18 65.9 1.9 9.1e-18 65.1 1.9 1.4 1 0 0 1 1 1 1 Universal stress protein family Polysacc_deac_1 PF01522.21 ETS63382.1 - 2.4e-13 50.1 0.0 5e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase GFA PF04828.14 ETS63382.1 - 3.6e-07 30.4 0.8 1.2e-05 25.6 0.8 2.5 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Arm-DNA-bind_3 PF13356.6 ETS63382.1 - 0.065 13.6 0.1 0.54 10.7 0.0 2.4 2 0 0 2 2 2 0 Arm DNA-binding domain Acetyltransf_1 PF00583.25 ETS63383.1 - 2.9e-08 34.0 0.0 7.9e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Mss4 PF04421.13 ETS63383.1 - 1.2e-07 31.8 4.2 0.021 15.0 4.7 3.0 2 1 0 2 2 2 2 Mss4 protein Acetyltransf_7 PF13508.7 ETS63383.1 - 4.9e-07 30.1 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETS63383.1 - 0.00026 20.9 0.0 0.0033 17.4 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS63383.1 - 0.009 16.0 0.0 0.066 13.2 0.0 2.3 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.7 ETS63383.1 - 0.0096 16.0 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ETS63383.1 - 0.04 13.4 0.0 0.072 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative acetyl-transferase Acetyltransf_13 PF13880.6 ETS63383.1 - 0.053 13.5 0.0 0.33 10.9 0.0 2.2 3 0 0 3 3 2 0 ESCO1/2 acetyl-transferase Acetyltransf_CG PF14542.6 ETS63383.1 - 0.062 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase NARP1 PF12569.8 ETS63383.1 - 0.21 10.5 12.3 0.42 9.5 12.3 1.4 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DDHD PF02862.17 ETS63383.1 - 0.51 10.5 8.4 0.74 9.9 0.4 2.7 3 0 0 3 3 3 0 DDHD domain Adaptin_binding PF10199.9 ETS63383.1 - 0.53 10.9 10.1 0.22 12.2 7.1 1.8 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 U1snRNP70_N PF12220.8 ETS63383.1 - 0.58 10.8 8.7 2.5 8.8 8.7 2.1 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PPL5 PF18168.1 ETS63383.1 - 3.9 6.7 7.1 8 5.7 7.1 1.4 1 0 0 1 1 1 0 Prim-pol family 5 CDC45 PF02724.14 ETS63383.1 - 3.9 5.7 9.7 6.5 4.9 9.7 1.3 1 0 0 1 1 1 0 CDC45-like protein ATP-synt_E PF05680.12 ETS63383.1 - 4.6 7.6 9.8 10 6.6 9.8 1.5 1 0 0 1 1 1 0 ATP synthase E chain Cellulase PF00150.18 ETS63385.1 - 4e-13 49.4 0.0 7.5e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Abhydrolase_3 PF07859.13 ETS63386.1 - 3.9e-10 39.9 0.6 5.9e-10 39.4 0.6 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS63386.1 - 4.6e-08 33.9 1.7 5.7e-08 33.6 1.7 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS63386.1 - 1.8e-06 27.4 0.2 3.7e-06 26.4 0.2 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 COesterase PF00135.28 ETS63386.1 - 0.0011 17.9 0.0 0.0017 17.3 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family DUF900 PF05990.12 ETS63386.1 - 0.0021 17.6 0.0 0.77 9.2 0.0 2.6 1 1 1 2 2 2 2 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_1 PF00561.20 ETS63386.1 - 0.028 14.1 0.5 0.049 13.3 0.5 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 ETS63386.1 - 0.054 13.0 0.0 0.082 12.5 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Peptidase_S9 PF00326.21 ETS63386.1 - 0.091 12.2 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family Abhydrolase_5 PF12695.7 ETS63386.1 - 0.14 11.9 0.4 7.6 6.3 0.1 2.6 2 1 0 2 2 2 0 Alpha/beta hydrolase family Thioesterase PF00975.20 ETS63386.1 - 0.15 12.2 0.0 1.9 8.6 0.0 2.2 2 0 0 2 2 2 0 Thioesterase domain DUF2103 PF09876.9 ETS63387.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Predicted metal-binding protein (DUF2103) Abhydrolase_2 PF02230.16 ETS63388.1 - 8.7e-56 189.1 0.0 1.1e-55 188.9 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ETS63388.1 - 5.1e-08 32.5 0.2 0.011 15.0 0.2 3.1 2 1 1 3 3 3 3 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS63388.1 - 3.6e-07 31.0 0.1 4.7e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETS63388.1 - 0.00014 21.6 0.7 0.016 14.9 0.2 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETS63388.1 - 0.00036 20.1 0.2 0.017 14.6 0.0 2.5 2 1 1 3 3 3 1 Prolyl oligopeptidase family Esterase PF00756.20 ETS63388.1 - 0.002 17.8 0.0 0.0027 17.4 0.0 1.2 1 0 0 1 1 1 1 Putative esterase FSH1 PF03959.13 ETS63388.1 - 0.0025 17.5 0.0 0.019 14.7 0.0 2.2 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Esterase_phd PF10503.9 ETS63388.1 - 0.0027 17.3 0.1 0.29 10.6 0.1 2.2 1 1 1 2 2 2 1 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 ETS63388.1 - 0.0029 17.5 0.2 0.054 13.4 0.2 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold DLH PF01738.18 ETS63388.1 - 0.0035 16.9 0.0 0.0049 16.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family AXE1 PF05448.12 ETS63388.1 - 0.017 13.8 0.0 0.026 13.2 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Cutinase PF01083.22 ETS63388.1 - 0.027 14.4 0.0 0.22 11.4 0.0 2.0 2 0 0 2 2 2 0 Cutinase Lipase_3 PF01764.25 ETS63388.1 - 0.051 13.4 0.0 0.084 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) ADH_zinc_N PF00107.26 ETS63389.1 - 6.1e-27 94.2 0.2 1e-26 93.4 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS63389.1 - 3.2e-13 50.9 0.0 7.7e-13 49.7 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS63389.1 - 1.6e-09 37.6 0.0 3.8e-08 33.2 0.0 2.4 1 1 1 2 2 2 2 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ETS63389.1 - 0.00092 19.1 0.0 0.0019 18.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase PAF-AH_p_II PF03403.13 ETS63392.1 - 2.1e-43 148.3 0.0 9.1e-41 139.6 0.0 3.9 3 1 0 3 3 3 1 Platelet-activating factor acetylhydrolase, isoform II Hydrolase_4 PF12146.8 ETS63392.1 - 4.8e-07 29.3 0.0 0.0025 17.1 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ETS63392.1 - 0.0016 17.4 0.0 0.025 13.5 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 ETS63392.1 - 0.034 13.2 0.0 0.093 11.7 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase Hid1 PF12722.7 ETS63392.1 - 0.55 8.3 1.9 0.82 7.7 1.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETS63392.1 - 1.8 7.2 8.8 3.8 6.2 8.8 1.4 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 ETS63392.1 - 2.6 6.6 5.9 4.2 6.0 5.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Apolipoprotein PF01442.18 ETS63393.1 - 2.3e-10 40.7 64.1 0.00017 21.5 1.8 4.4 1 1 3 4 4 4 3 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 ETS63393.1 - 5.3e-07 30.2 84.6 0.06 13.9 0.8 9.9 2 2 8 10 10 10 6 Bacterial protein of unknown function (DUF883) ApoO PF09769.9 ETS63393.1 - 3.2 7.7 23.8 0.28 11.1 0.4 6.1 2 2 3 6 6 6 0 Apolipoprotein O MbeB_N PF04837.12 ETS63393.1 - 6 7.2 8.7 0.54 10.6 0.3 3.5 3 0 0 3 3 3 0 MbeB-like, N-term conserved region Acetyltransf_3 PF13302.7 ETS63394.1 - 3.4e-22 79.6 0.0 4.5e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ETS63394.1 - 1.1e-05 25.1 0.6 0.31 10.7 0.0 3.0 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS63394.1 - 0.01 16.0 0.0 4.4 7.6 0.0 2.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETS63394.1 - 0.056 13.9 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain VCX_VCY PF15231.6 ETS63394.1 - 0.059 14.0 0.7 9.1 7.0 0.2 2.2 2 0 0 2 2 2 0 Variable charge X/Y family FR47 PF08445.10 ETS63394.1 - 0.074 13.0 0.0 0.16 11.9 0.0 1.6 2 0 0 2 2 2 0 FR47-like protein zf-C2H2 PF00096.26 ETS63395.1 - 5.3e-34 114.8 66.5 0.0001 22.6 0.2 10.6 10 0 0 10 10 10 9 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS63395.1 - 9.6e-21 72.7 66.0 0.041 14.7 2.4 10.7 10 0 0 10 10 10 9 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ETS63395.1 - 6.4e-11 42.4 21.2 0.00025 21.3 4.5 5.0 3 1 0 4 4 4 3 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 ETS63395.1 - 8.1e-09 35.5 2.9 1.3e-05 25.4 0.2 10.4 11 1 0 11 11 11 4 Zinc-finger double domain FOXP-CC PF16159.5 ETS63395.1 - 1.4e-06 28.8 37.4 0.019 15.6 0.2 7.8 7 1 1 8 8 8 3 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 ETS63395.1 - 0.029 14.5 17.6 5.2 7.2 0.1 5.6 4 1 1 6 6 6 0 Aberrant zinc-finger zf-C2H2_12 PF18658.1 ETS63395.1 - 0.03 13.9 8.8 3 7.5 0.4 4.1 3 1 1 4 4 4 0 Zinc-finger C2H2-type FYDLN_acid PF09538.10 ETS63395.1 - 0.11 13.2 0.2 0.11 13.2 0.2 5.4 5 1 1 6 6 6 0 Protein of unknown function (FYDLN_acid) IBR PF01485.21 ETS63395.1 - 2.1 8.7 27.0 2.8 8.2 1.0 4.9 4 2 0 4 4 4 0 IBR domain, a half RING-finger domain zf_ZIC PF18366.1 ETS63395.1 - 3.4 7.8 7.5 11 6.3 0.0 4.7 5 0 0 5 5 5 0 Zic proteins zinc finger domain CHORD PF04968.12 ETS63395.1 - 3.8 8.3 35.3 11 6.9 0.8 7.4 6 1 1 7 7 7 0 CHORD zf-SNAP50_C PF12251.8 ETS63396.1 - 2.4e-10 40.4 0.0 2.6e-09 37.1 0.0 2.4 2 1 0 2 2 2 1 snRNA-activating protein of 50kDa MW C terminal GTP_EFTU PF00009.27 ETS63397.1 - 2.5e-56 190.3 0.1 3.8e-56 189.7 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETS63397.1 - 2.1e-29 102.1 0.0 4.1e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETS63397.1 - 1.4e-16 60.6 3.6 1.4e-16 60.6 3.6 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETS63397.1 - 8.7e-05 22.6 0.1 0.00018 21.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS63397.1 - 0.0058 16.6 0.0 0.017 15.0 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 ETS63397.1 - 0.0099 15.5 0.5 0.022 14.3 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 ETS63397.1 - 0.062 13.0 0.2 7.3 6.3 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Dus PF01207.17 ETS63398.1 - 6.5e-46 156.8 0.0 1.9e-45 155.3 0.0 1.7 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 ETS63398.1 - 0.00012 21.4 0.0 0.00025 20.3 0.0 1.5 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase CHCH PF06747.13 ETS63399.1 - 1.1e-05 25.4 1.1 1.4e-05 25.1 1.1 1.1 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 ETS63399.1 - 0.00068 19.6 0.7 0.00091 19.2 0.7 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 ETS63399.1 - 0.047 13.7 0.1 0.072 13.1 0.1 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, HTH_5 PF01022.20 ETS63399.1 - 0.086 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Sec61_beta PF03911.16 ETS63400.1 - 9.9e-18 63.9 2.2 1.3e-17 63.6 2.2 1.1 1 0 0 1 1 1 1 Sec61beta family RecQ5 PF06959.11 ETS63400.1 - 0.021 14.8 2.6 0.022 14.7 2.6 1.0 1 0 0 1 1 1 0 RecQ helicase protein-like 5 (RecQ5) Fasciclin PF02469.22 ETS63402.1 - 1.2e-23 83.7 4.1 2.1e-16 60.3 0.3 2.3 2 0 0 2 2 2 2 Fasciclin domain Kdo PF06293.14 ETS63403.1 - 1.1e-05 24.9 0.2 8.9e-05 21.9 0.2 2.1 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ETS63403.1 - 5.9e-05 22.6 0.0 9.8e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain APH PF01636.23 ETS63403.1 - 0.00013 21.9 0.2 0.0078 16.2 0.1 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 ETS63403.1 - 0.0019 17.8 0.1 0.12 12.0 0.1 2.4 2 0 0 2 2 2 1 RIO1 family Pkinase_Tyr PF07714.17 ETS63403.1 - 0.035 13.4 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase 4HBT PF03061.22 ETS63404.1 - 0.00019 21.8 0.1 0.00036 20.8 0.1 1.5 1 0 0 1 1 1 1 Thioesterase superfamily ANAPC5 PF12862.7 ETS63405.1 - 1.4e-12 47.5 2.2 1.4e-11 44.3 0.2 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 5 TPR_8 PF13181.6 ETS63405.1 - 0.0088 16.2 0.2 0.63 10.4 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETS63405.1 - 0.031 14.4 0.5 9.1 6.7 0.0 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETS63405.1 - 0.061 13.6 0.2 0.061 13.6 0.2 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETS63405.1 - 0.36 10.8 0.1 0.36 10.8 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETS63405.1 - 0.38 11.7 0.1 0.38 11.7 0.1 6.1 6 1 0 6 6 6 0 Tetratricopeptide repeat Arfaptin PF06456.13 ETS63406.1 - 0.013 15.1 11.1 0.021 14.4 11.1 1.2 1 0 0 1 1 1 0 Arfaptin-like domain DUF885 PF05960.11 ETS63406.1 - 0.088 12.4 16.5 0.048 13.3 13.2 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) Prominin PF05478.11 ETS63406.1 - 0.24 9.3 6.1 0.34 8.8 6.1 1.1 1 0 0 1 1 1 0 Prominin CorA PF01544.18 ETS63406.1 - 7.4 5.8 7.5 12 5.1 7.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Sec7 PF01369.20 ETS63407.1 - 9.5e-34 116.7 0.2 1.5e-33 116.0 0.2 1.2 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 ETS63407.1 - 1.2e-13 51.5 0.0 2.6e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ETS63407.1 - 1.3e-10 41.7 0.0 4.4e-10 40.0 0.0 2.0 1 1 0 1 1 1 1 PH domain PH_6 PF15406.6 ETS63407.1 - 0.0025 18.1 1.0 0.0096 16.2 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain adh_short PF00106.25 ETS63408.1 - 2.3e-85 285.0 13.3 1.5e-42 145.3 4.3 2.5 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63408.1 - 1.4e-68 231.0 16.3 2e-35 122.5 3.4 3.2 2 2 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 ETS63408.1 - 7.6e-33 112.7 0.0 1.4e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 ETS63408.1 - 6.2e-32 111.0 7.1 2.1e-16 60.4 0.6 2.3 2 0 0 2 2 2 2 KR domain THF_DHG_CYH_C PF02882.19 ETS63408.1 - 5.7e-05 22.5 0.1 0.015 14.7 0.1 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 ETS63408.1 - 0.018 14.9 5.9 0.43 10.4 0.2 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF543 PF04418.12 ETS63408.1 - 0.057 13.4 5.1 3 7.9 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF543) MaoC_dehydrat_N PF13452.6 ETS63408.1 - 0.068 13.3 0.0 7.3 6.7 0.0 2.4 2 0 0 2 2 2 0 N-terminal half of MaoC dehydratase PglL_A PF15864.5 ETS63408.1 - 0.93 9.3 8.1 5.5 6.8 1.0 2.6 2 0 0 2 2 2 0 Protein glycosylation ligase Cation_efflux PF01545.21 ETS63409.1 - 2.3e-44 151.5 0.3 4.6e-44 150.5 0.3 1.5 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETS63409.1 - 2e-07 31.0 0.4 4.7e-07 29.8 0.0 1.7 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter SelP_N PF04592.14 ETS63409.1 - 0.85 9.0 6.1 1.7 8.0 6.1 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PH PF00169.29 ETS63410.1 - 8.1e-35 119.5 0.8 1.7e-19 70.3 0.9 3.2 3 0 0 3 3 3 3 PH domain PH_3 PF14593.6 ETS63410.1 - 1.4e-17 63.6 5.2 9.4e-09 35.3 1.3 3.2 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 ETS63410.1 - 6e-15 55.6 9.8 1.3e-06 28.7 6.3 4.2 3 1 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 ETS63410.1 - 1.1e-09 38.5 3.9 7.1e-07 29.4 1.4 2.6 3 0 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 ETS63410.1 - 0.00017 21.9 0.6 0.11 12.9 0.9 3.4 3 1 0 3 3 3 1 Pleckstrin homology domain PH_15 PF17339.2 ETS63410.1 - 0.00027 20.8 1.2 0.018 14.9 0.5 2.2 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 ETS63410.1 - 0.0021 17.9 0.5 0.051 13.4 0.3 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_4 PF15404.6 ETS63410.1 - 0.024 14.5 1.2 13 5.5 0.0 3.2 2 1 1 3 3 3 0 Pleckstrin homology domain Mcp5_PH PF12814.7 ETS63410.1 - 0.14 12.2 0.8 17 5.5 0.0 2.8 3 0 0 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology CENP-B_dimeris PF09026.10 ETS63410.1 - 4.9 7.6 8.7 21 5.6 3.0 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ESSS PF10183.9 ETS63411.1 - 7.8e-13 48.5 0.2 1.3e-12 47.9 0.2 1.3 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) COesterase PF00135.28 ETS63412.1 - 4.4e-72 243.6 0.0 7.1e-72 242.9 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS63412.1 - 5.1e-11 42.8 0.4 2.6e-10 40.5 0.2 2.2 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETS63412.1 - 4.6e-05 23.0 0.3 0.0001 21.9 0.3 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ETS63412.1 - 0.0096 16.5 2.5 0.011 16.3 0.5 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family zf-AN1 PF01428.16 ETS63413.1 - 4e-19 68.5 31.8 6.4e-10 39.0 8.3 2.5 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 ETS63413.1 - 4.3 7.6 19.4 0.88 9.8 6.6 2.6 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain CxC5 PF18718.1 ETS63413.1 - 4.4 7.4 9.1 4.4 7.4 0.4 2.4 2 0 0 2 2 2 0 CxC5 like cysteine cluster associated with KDZ transposases zf-HIT PF04438.16 ETS63413.1 - 6.6 6.7 16.6 0.56 10.1 2.3 3.4 3 0 0 3 3 3 0 HIT zinc finger 2OG-FeII_Oxy_2 PF13532.6 ETS63414.1 - 6.6e-24 85.2 0.2 1.1e-23 84.5 0.0 1.4 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily MFAP1 PF06991.11 ETS63414.1 - 0.017 15.0 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing 2OG-FeII_Oxy PF03171.20 ETS63414.1 - 0.051 14.1 0.0 0.14 12.7 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily PK PF00224.21 ETS63415.1 - 9.6e-161 534.4 5.5 1.2e-160 534.1 5.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ETS63415.1 - 2.7e-36 124.3 0.0 7e-36 123.0 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ETS63415.1 - 0.00094 18.4 0.2 0.0029 16.8 0.2 1.9 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 ETS63415.1 - 0.044 12.8 0.3 0.33 9.9 0.0 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF218 PF02698.17 ETS63415.1 - 0.085 12.9 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 DUF218 domain ELO PF01151.18 ETS63416.1 - 8.4e-58 195.8 8.0 1e-57 195.5 8.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family SNAP PF14938.6 ETS63418.1 - 2.8e-99 332.1 16.4 3.1e-99 331.9 16.4 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 ETS63418.1 - 1.8e-05 24.9 18.4 0.018 15.3 0.6 4.4 1 1 4 5 5 5 3 Tetratricopeptide repeat Spatacsin_C PF14649.6 ETS63418.1 - 0.0039 16.4 1.0 0.0039 16.4 1.0 2.0 1 1 1 2 2 2 1 Spatacsin C-terminus RNA_pol_Rpb6 PF01192.22 ETS63418.1 - 0.071 13.0 0.1 1.4 8.9 0.3 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb6 TPR_6 PF13174.6 ETS63418.1 - 0.56 11.0 18.5 5.1 7.9 0.4 5.9 4 2 1 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETS63418.1 - 1.6 8.7 18.0 13 5.8 1.7 6.1 5 2 2 7 7 7 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETS63418.1 - 9.6 6.0 19.5 7.8 6.3 0.1 5.6 3 2 3 6 6 6 0 TPR repeat Acetyltransf_10 PF13673.7 ETS63420.1 - 9.8e-09 35.2 0.1 0.00032 20.6 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS63420.1 - 4.5e-06 27.0 0.1 1.4e-05 25.4 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_5 PF13444.6 ETS63420.1 - 2.3e-05 25.0 0.0 0.00018 22.1 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS63420.1 - 0.00018 21.7 0.0 0.0026 18.0 0.0 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ETS63420.1 - 0.002 18.1 0.1 0.023 14.7 0.1 2.2 2 0 0 2 2 2 1 FR47-like protein CAP_GLY PF01302.25 ETS63421.1 - 7.9e-26 89.9 1.3 1.2e-25 89.3 1.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 ETS63421.1 - 6.8e-13 48.9 0.0 7.7e-12 45.5 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin-like domain RRM_1 PF00076.22 ETS63422.1 - 2.4e-39 133.0 0.1 2.1e-20 72.3 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 ETS63422.1 - 1.5e-14 54.9 1.5 7.4e-14 52.6 1.5 2.2 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 ETS63422.1 - 0.0002 21.2 0.0 0.0011 18.8 0.0 2.2 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 ETS63422.1 - 0.00086 19.3 0.1 0.0049 16.9 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 ETS63422.1 - 0.092 12.8 0.1 17 5.5 0.0 2.8 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif TSP_3 PF02412.18 ETS63422.1 - 4 7.2 5.2 0.72 9.6 0.1 2.2 2 0 0 2 2 2 0 Thrombospondin type 3 repeat ANAPC4_WD40 PF12894.7 ETS63423.1 - 1.4e-10 41.3 0.4 0.0019 18.5 0.0 5.6 5 2 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETS63423.1 - 5.8e-05 23.8 15.4 0.57 11.1 0.1 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF2A PF08662.11 ETS63423.1 - 0.00021 21.2 0.0 1.7 8.5 0.0 4.0 5 0 0 5 5 5 1 Eukaryotic translation initiation factor eIF2A DPPIV_N PF00930.21 ETS63423.1 - 0.11 11.2 0.2 55 2.4 0.0 3.8 4 0 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Lactonase PF10282.9 ETS63423.1 - 0.19 10.9 0.0 5.6 6.1 0.0 2.8 4 0 0 4 4 4 0 Lactonase, 7-bladed beta-propeller PD40 PF07676.12 ETS63423.1 - 1.1 9.3 4.2 6.3 6.9 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat ELP6 PF09807.9 ETS63424.1 - 8e-13 48.4 0.1 3.2e-12 46.4 0.0 1.8 2 1 0 2 2 2 1 Elongation complex protein 6 Elong_Iki1 PF10483.9 ETS63424.1 - 0.0021 17.6 0.0 0.017 14.7 0.0 2.0 1 1 0 1 1 1 1 Elongator subunit Iki1 Glycos_transf_1 PF00534.20 ETS63425.1 - 1.6e-31 109.2 0.0 2e-30 105.6 0.0 2.5 3 0 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ETS63425.1 - 8.2e-25 87.8 0.4 1.7e-24 86.7 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 ETS63425.1 - 1e-24 87.5 0.1 3.2e-24 85.9 0.1 1.9 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ETS63425.1 - 1.8e-15 57.7 0.7 5.6e-15 56.1 0.1 2.2 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ETS63425.1 - 0.025 15.0 0.1 0.4 11.1 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferases group 1 FCH PF00611.23 ETS63426.1 - 7.3e-16 58.2 1.8 3.2e-15 56.2 0.1 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 ETS63426.1 - 3.1e-12 45.9 0.1 5.6e-12 45.1 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS63426.1 - 4.4e-11 42.5 0.0 8.4e-11 41.6 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETS63426.1 - 1.7e-08 34.0 0.0 4.5e-08 32.6 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain CorA PF01544.18 ETS63427.1 - 4.4e-14 52.5 6.1 5.1e-08 32.6 0.1 3.8 4 0 0 4 4 4 3 CorA-like Mg2+ transporter protein Yip1 PF04893.17 ETS63427.1 - 0.15 11.8 0.5 0.25 11.1 0.5 1.2 1 0 0 1 1 1 0 Yip1 domain COX7C PF02935.16 ETS63428.1 - 8.8e-16 57.9 1.1 1e-15 57.7 1.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Brix PF04427.18 ETS63429.1 - 4e-23 82.5 0.0 5.8e-23 82.0 0.0 1.2 1 0 0 1 1 1 1 Brix domain WD40 PF00400.32 ETS63430.1 - 8.4e-19 67.6 9.2 6.7e-07 29.9 0.7 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63430.1 - 3.8e-14 52.8 0.0 0.0023 18.2 0.1 4.9 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ETS63430.1 - 1e-05 25.2 0.8 0.00037 20.2 0.2 2.3 2 0 0 2 2 2 1 PQQ-like domain Hira PF07569.11 ETS63430.1 - 0.0023 17.7 0.1 9.5 5.9 0.0 3.6 1 1 2 3 3 3 1 TUP1-like enhancer of split eIF2A PF08662.11 ETS63430.1 - 0.0083 16.0 0.1 6.6 6.6 0.1 3.2 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETS63430.1 - 0.015 13.8 0.3 5.9 5.3 0.0 3.1 3 0 0 3 3 3 0 Cytochrome D1 heme domain DUF4727 PF15856.5 ETS63430.1 - 0.033 13.8 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4727) PQQ_3 PF13570.6 ETS63430.1 - 0.057 13.9 1.8 27 5.4 0.0 3.8 3 0 0 3 3 3 0 PQQ-like domain Neuropep_like PF15161.6 ETS63430.1 - 0.06 13.0 0.8 0.14 11.9 0.1 1.9 2 0 0 2 2 2 0 Neuropeptide-like CRT10 PF08728.10 ETS63430.1 - 0.19 9.9 0.0 0.3 9.2 0.0 1.2 1 0 0 1 1 1 0 CRT10 COesterase PF00135.28 ETS63431.1 - 1.4e-97 327.7 0.0 1.8e-97 327.4 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS63431.1 - 4.5e-05 23.4 1.4 0.00037 20.4 1.1 2.4 1 1 1 2 2 2 1 alpha/beta hydrolase fold Zn_clus PF00172.18 ETS63432.1 - 0.018 15.1 5.7 0.035 14.2 5.7 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Atg14 PF10186.9 ETS63433.1 - 1.5 7.8 6.6 2.4 7.2 3.4 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 RRP36 PF06102.12 ETS63434.1 - 1.1e-46 158.8 22.0 1.1e-46 158.8 22.0 2.8 2 1 0 2 2 2 1 rRNA biogenesis protein RRP36 BING4CT PF08149.11 ETS63435.1 - 5.4e-33 112.6 0.0 1.1e-30 105.2 0.0 3.2 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 ETS63435.1 - 1.4e-07 32.1 0.6 0.036 14.9 0.0 5.0 5 0 0 5 5 5 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 ETS63435.1 - 9.3e-05 21.6 0.0 0.00014 21.1 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region ANAPC4_WD40 PF12894.7 ETS63435.1 - 0.0027 18.0 0.0 1.8 8.9 0.0 3.4 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain GFO_IDH_MocA PF01408.22 ETS63436.1 - 1.9e-12 48.0 0.4 4.2e-12 46.9 0.4 1.8 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold AMP-binding PF00501.28 ETS63436.1 - 0.011 14.3 0.0 0.017 13.8 0.0 1.2 1 0 0 1 1 1 0 AMP-binding enzyme CoA_binding_2 PF13380.6 ETS63436.1 - 0.11 13.1 0.0 0.23 12.0 0.0 1.5 1 0 0 1 1 1 0 CoA binding domain Syja_N PF02383.18 ETS63437.1 - 9.2e-91 304.5 0.2 1.2e-90 304.1 0.2 1.1 1 0 0 1 1 1 1 SacI homology domain JAB PF01398.21 ETS63438.1 - 1.1e-24 86.6 0.0 1.7e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ETS63438.1 - 6.1e-18 65.3 0.7 1.3e-17 64.2 0.3 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function SH2_2 PF14633.6 ETS63439.1 - 1.4e-76 256.7 0.0 1.4e-76 256.7 0.0 1.9 2 0 0 2 2 2 1 SH2 domain HHH_7 PF14635.6 ETS63439.1 - 5.3e-22 78.1 0.0 1e-21 77.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 ETS63439.1 - 7.1e-22 77.8 0.0 1.8e-21 76.5 0.0 1.7 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HTH_44 PF14641.6 ETS63439.1 - 4e-21 75.6 0.3 9.3e-21 74.4 0.3 1.6 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 ETS63439.1 - 1.2e-18 67.5 26.0 1.2e-18 67.5 26.0 4.8 2 1 2 4 4 4 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 ETS63439.1 - 0.0012 19.7 1.0 0.0012 19.7 1.0 3.3 3 1 0 3 3 3 1 HHH domain HHH_3 PF12836.7 ETS63439.1 - 0.0025 18.0 0.0 0.0068 16.6 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif SH2 PF00017.24 ETS63439.1 - 0.008 16.3 0.0 0.03 14.4 0.0 2.1 1 0 0 1 1 1 1 SH2 domain DUF3381 PF11861.8 ETS63439.1 - 2.9 7.7 17.8 3.9 7.2 1.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3381) LRRC37AB_C PF14914.6 ETS63440.1 - 0.014 15.3 0.0 0.021 14.7 0.0 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain MFS_1 PF07690.16 ETS63441.1 - 1.7e-24 86.4 18.9 1e-19 70.7 6.2 2.3 2 1 0 2 2 2 2 Major Facilitator Superfamily Nodulin-like PF06813.13 ETS63441.1 - 5.7e-14 52.2 3.1 5.7e-14 52.2 3.1 2.9 3 0 0 3 3 3 2 Nodulin-like Rad21_Rec8_N PF04825.13 ETS63442.1 - 3.2e-29 101.3 0.0 5.7e-29 100.5 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ETS63442.1 - 3.8e-09 35.7 0.5 3.8e-09 35.7 0.5 2.1 2 0 0 2 2 2 1 Conserved region of Rad21 / Rec8 like protein Autophagy_N PF03986.13 ETS63444.1 - 1.1e-40 138.8 0.0 2e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 ETS63444.1 - 7.9e-19 68.0 0.0 1.7e-18 66.9 0.0 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 ETS63444.1 - 2.6e-13 49.2 0.8 5.3e-13 48.2 0.8 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal BLUF PF04940.12 ETS63445.1 - 1.6e-30 105.1 0.0 2.5e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Sensors of blue-light using FAD SPX PF03105.19 ETS63445.1 - 0.087 12.7 6.2 0.1 12.5 6.2 1.2 1 0 0 1 1 1 0 SPX domain NUC153 PF08159.12 ETS63446.1 - 8.4e-15 54.3 13.6 5.2e-12 45.4 1.1 3.7 3 0 0 3 3 3 3 NUC153 domain LSM PF01423.22 ETS63447.1 - 3.9e-22 77.7 0.1 4.5e-22 77.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ETS63447.1 - 0.0046 17.1 0.0 0.0058 16.7 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 ETS63447.1 - 0.084 13.0 0.0 0.099 12.8 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain Bud13 PF09736.9 ETS63448.1 - 7.3e-45 152.9 2.3 7.3e-45 152.9 2.3 2.2 2 0 0 2 2 2 1 Pre-mRNA-splicing factor of RES complex bMG3 PF11974.8 ETS63448.1 - 0.015 15.3 0.2 0.015 15.3 0.2 2.3 2 1 0 2 2 2 0 Bacterial alpha-2-macroglobulin MG3 domain DUF1418 PF07214.12 ETS63450.1 - 0.17 11.8 0.1 3.4 7.6 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1418) Zn_clus PF00172.18 ETS63451.1 - 1.2e-05 25.4 4.2 2.3e-05 24.4 4.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gpr1_Fun34_YaaH PF01184.19 ETS63452.1 - 4.2e-86 287.8 20.1 5.7e-86 287.4 20.1 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Transglycosylas PF06737.14 ETS63452.1 - 3.1 8.5 6.8 5.7 7.7 0.4 2.9 3 0 0 3 3 3 0 Transglycosylase-like domain Ribosomal_L31e PF01198.19 ETS63454.1 - 1.5e-38 130.9 0.9 2.2e-38 130.4 0.9 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e JAB PF01398.21 ETS63455.1 - 7.2e-06 26.0 0.0 1.3e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease DUF4203 PF13886.6 ETS63457.1 - 9.3e-49 165.8 24.8 1.4e-48 165.3 24.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) FA_desaturase PF00487.24 ETS63457.1 - 2.6 7.8 6.0 5.7 6.7 6.0 1.6 1 0 0 1 1 1 0 Fatty acid desaturase Pro_CA PF00484.19 ETS63458.1 - 3e-37 128.3 0.1 5.3e-37 127.5 0.1 1.4 1 0 0 1 1 1 1 Carbonic anhydrase Abhydrolase_1 PF00561.20 ETS63458.1 - 0.0082 15.8 0.0 0.027 14.1 0.0 1.7 1 1 0 2 2 2 1 alpha/beta hydrolase fold p450 PF00067.22 ETS63459.1 - 1.5e-54 185.5 0.0 2.9e-54 184.6 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 VASP_tetra PF08776.11 ETS63459.1 - 0.3 10.7 3.5 0.76 9.4 3.5 1.7 1 0 0 1 1 1 0 VASP tetramerisation domain E1-E2_ATPase PF00122.20 ETS63461.1 - 9.4e-43 145.8 13.7 1.2e-42 145.5 2.1 3.9 3 1 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETS63461.1 - 1.6e-31 109.4 4.0 1.6e-31 109.4 4.0 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETS63461.1 - 5.3e-19 69.4 1.8 5.4e-18 66.0 1.8 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS63461.1 - 1.3e-18 66.8 0.0 3.5e-18 65.5 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ETS63461.1 - 1.7e-17 62.9 3.9 4e-17 61.7 0.1 3.3 3 0 0 3 3 3 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ETS63461.1 - 0.0025 17.6 0.1 0.019 14.7 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Raftlin PF15250.6 ETS63461.1 - 0.15 10.7 0.1 0.33 9.7 0.1 1.4 1 0 0 1 1 1 0 Raftlin HSP9_HSP12 PF04119.12 ETS63462.1 - 2.5e-23 82.2 13.2 1e-19 70.7 4.3 2.1 1 1 1 2 2 2 2 Heat shock protein 9/12 MT0933_antitox PF14013.6 ETS63462.1 - 0.024 14.9 10.4 41 4.6 10.4 2.5 1 1 0 1 1 1 0 MT0933-like antitoxin protein Sugar_tr PF00083.24 ETS63463.1 - 6.1e-22 78.1 19.3 1.7e-20 73.3 4.9 2.2 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETS63463.1 - 6.2e-21 74.7 57.9 8.8e-15 54.5 30.2 3.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ETS63463.1 - 0.00095 18.6 6.1 0.00095 18.6 6.1 2.3 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB UPF0126 PF03458.13 ETS63463.1 - 0.0091 15.9 1.9 0.0091 15.9 1.9 2.3 2 0 0 2 2 2 1 UPF0126 domain Mito_carr PF00153.27 ETS63464.1 - 5.3e-62 205.8 4.3 4e-22 77.9 0.0 4.3 4 0 0 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 ETS63464.1 - 0.056 12.6 2.5 0.24 10.5 0.0 2.7 3 0 0 3 3 3 0 Gammaproteobacterial serine protease MSC PF09402.10 ETS63465.1 - 2e-93 313.5 0.5 2.8e-93 313.1 0.5 1.2 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 ETS63465.1 - 3.6e-14 52.2 0.0 1.1e-13 50.6 0.0 1.9 1 0 0 1 1 1 1 HeH/LEM domain FAD_binding_3 PF01494.19 ETS63467.1 - 8.4e-15 54.9 0.1 3.8e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 ETS63467.1 - 3.4e-06 26.5 0.1 0.00018 20.8 0.0 2.1 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS63467.1 - 7e-05 23.3 0.0 0.51 10.9 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS63467.1 - 0.0071 16.0 0.0 0.014 15.0 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Spc24 PF08286.11 ETS63470.1 - 4.4e-08 33.3 19.1 4.8e-06 26.8 6.4 3.4 2 2 1 3 3 3 2 Spc24 subunit of Ndc80 Spectrin_like PF18373.1 ETS63470.1 - 0.0074 16.3 2.1 0.0074 16.3 2.1 2.4 2 1 1 3 3 3 1 Spectrin like domain Filament PF00038.21 ETS63470.1 - 0.014 15.0 16.6 0.52 9.9 16.5 1.9 1 1 0 1 1 1 0 Intermediate filament protein Rootletin PF15035.6 ETS63470.1 - 0.024 14.6 14.1 0.073 13.1 0.6 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Sec2p PF06428.11 ETS63470.1 - 0.17 11.9 13.2 0.73 9.8 9.8 2.7 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p FliD_N PF02465.18 ETS63470.1 - 0.3 11.8 8.9 3.3 8.4 1.2 2.4 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus FlaC_arch PF05377.11 ETS63470.1 - 1.9 8.9 7.5 3.6 8.0 2.7 2.9 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.8 ETS63470.1 - 1.9 8.5 16.9 0.22 11.5 6.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding V_ATPase_I PF01496.19 ETS63470.1 - 2.2 6.1 8.1 2.5 5.9 8.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FapA PF03961.13 ETS63470.1 - 3 6.3 8.0 5 5.6 7.8 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 ETS63470.1 - 3.6 7.8 8.0 15 5.8 8.0 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SLX9 PF15341.6 ETS63470.1 - 5.8 7.3 13.8 25 5.3 13.8 1.9 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 FUSC PF04632.12 ETS63470.1 - 6.4 5.2 8.0 7.4 5.0 8.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Vac_ImportDeg PF09783.9 ETS63471.1 - 1.2e-54 184.5 0.0 4.3e-49 166.4 0.0 2.2 2 0 0 2 2 2 2 Vacuolar import and degradation protein Gpi1 PF05024.15 ETS63472.1 - 1.6e-55 188.1 5.4 2.5e-55 187.4 5.4 1.3 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) AA_kinase PF00696.28 ETS63473.1 - 7.1e-42 143.7 1.0 1e-41 143.2 1.0 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 ETS63473.1 - 2.1e-10 40.4 0.1 7e-05 22.7 0.0 2.7 2 0 0 2 2 2 2 PUA domain AAA PF00004.29 ETS63474.1 - 2.3e-17 63.7 0.1 8.7e-17 61.8 0.0 2.0 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ETS63474.1 - 1.4e-13 51.0 0.0 1.7e-11 44.2 0.0 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 ETS63474.1 - 1.4e-11 44.6 0.1 3.6e-11 43.3 0.1 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 ETS63474.1 - 3.3e-07 30.4 0.1 1.7e-06 28.1 0.1 2.0 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 ETS63474.1 - 1.8e-06 28.2 0.8 0.0064 16.8 0.0 3.2 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 ETS63474.1 - 1.6e-05 25.4 0.0 0.0011 19.4 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ETS63474.1 - 4.3e-05 23.4 0.6 0.00012 22.0 0.0 1.9 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 ETS63474.1 - 0.00013 21.7 0.1 0.00044 20.0 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ETS63474.1 - 0.00013 22.0 0.0 0.0011 19.0 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_assoc_2 PF16193.5 ETS63474.1 - 0.00032 21.0 0.0 0.0011 19.3 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_5 PF07728.14 ETS63474.1 - 0.00053 20.0 0.0 0.0021 18.1 0.0 2.0 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETS63474.1 - 0.00096 18.6 0.1 0.031 13.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 ETS63474.1 - 0.001 18.8 0.0 0.002 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETS63474.1 - 0.0011 18.6 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 ETS63474.1 - 0.0012 18.6 0.0 0.0058 16.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 ETS63474.1 - 0.0024 17.9 0.0 0.034 14.1 0.0 2.1 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETS63474.1 - 0.0024 18.2 0.2 0.013 15.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 ETS63474.1 - 0.0047 16.7 0.1 0.058 13.2 0.0 2.3 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_28 PF13521.6 ETS63474.1 - 0.016 15.4 0.0 0.036 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ETS63474.1 - 0.019 14.9 0.1 0.071 13.0 0.0 2.1 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ETS63474.1 - 0.02 14.0 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MCM PF00493.23 ETS63474.1 - 0.035 13.2 0.0 0.12 11.4 0.0 1.9 1 1 0 1 1 1 0 MCM P-loop domain Parvo_NS1 PF01057.17 ETS63474.1 - 0.045 12.8 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_18 PF13238.6 ETS63474.1 - 0.053 14.1 0.0 0.13 12.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ETS63474.1 - 0.058 13.5 0.0 0.2 11.8 0.0 1.9 3 0 0 3 3 1 0 AAA domain (Cdc48 subfamily) DUF2075 PF09848.9 ETS63474.1 - 0.07 12.4 0.0 0.29 10.3 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 ETS63474.1 - 0.12 12.3 0.0 0.51 10.2 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 ETS63474.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase DUF241 PF03087.14 ETS63474.1 - 2.2 8.0 5.8 14 5.5 0.1 2.3 2 0 0 2 2 2 0 Arabidopsis protein of unknown function CAF1A PF12253.8 ETS63475.1 - 9.2e-22 77.0 5.5 9.2e-22 77.0 5.5 3.1 2 2 1 3 3 3 1 Chromatin assembly factor 1 subunit A WD40 PF00400.32 ETS63476.1 - 2.7e-39 132.4 20.7 3.9e-07 30.7 0.4 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63476.1 - 1.3e-19 70.3 0.7 0.0046 17.2 0.0 5.8 2 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETS63476.1 - 2.7e-07 30.7 0.1 0.013 15.4 0.0 3.8 2 1 3 5 5 5 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETS63476.1 - 8e-07 28.3 0.0 0.0031 16.5 0.0 2.9 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 ETS63476.1 - 0.015 15.3 0.0 2.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region BDV_G PF06208.11 ETS63476.1 - 0.14 11.3 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Borna disease virus G protein MgtE PF01769.16 ETS63477.1 - 8.3e-40 136.0 34.6 7.2e-24 84.5 9.2 4.4 2 1 1 3 3 3 2 Divalent cation transporter MFS_1 PF07690.16 ETS63478.1 - 6.2e-19 68.1 63.2 4e-11 42.4 28.3 3.6 2 2 1 3 3 3 2 Major Facilitator Superfamily Tetraspanin PF00335.20 ETS63478.1 - 0.00053 19.8 6.2 0.00053 19.8 6.2 2.5 2 1 1 3 3 3 1 Tetraspanin family MIP PF00230.20 ETS63480.1 - 6.5e-51 173.2 17.0 9e-51 172.8 17.0 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF4271 PF14093.6 ETS63480.1 - 0.038 13.9 0.1 0.038 13.9 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4271) Phage_holin_5_2 PF16079.5 ETS63480.1 - 2.2 8.7 6.8 2.8 8.4 0.0 3.2 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V FMN_bind_2 PF04299.12 ETS63481.1 - 1.4e-52 177.8 0.0 1.6e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain DUF1325 PF07039.11 ETS63483.1 - 1.5e-27 96.3 0.0 2.7e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF4889 PF16230.5 ETS63483.1 - 0.19 12.0 0.1 0.45 10.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4889) E1-E2_ATPase PF00122.20 ETS63484.1 - 6e-45 153.0 3.0 6e-45 153.0 3.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ETS63484.1 - 7.1e-35 121.2 1.3 1.4e-34 120.2 0.3 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ETS63484.1 - 1.4e-32 111.9 0.1 9.5e-16 58.0 0.0 2.8 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 ETS63484.1 - 0.00011 22.6 0.0 0.00027 21.4 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETS63484.1 - 0.00014 21.7 0.5 0.0096 15.7 0.3 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETS63484.1 - 0.0094 16.1 0.0 0.077 13.1 0.0 2.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase AbiEi_2 PF09952.9 ETS63484.1 - 0.022 15.0 0.0 4.8 7.4 0.0 3.2 3 0 0 3 3 3 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system HAD_2 PF13419.6 ETS63484.1 - 0.19 11.8 0.0 0.6 10.2 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase TFIIA PF03153.13 ETS63485.1 - 8.1 6.3 5.6 0.78 9.7 0.5 1.9 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit FMO-like PF00743.19 ETS63487.1 - 1.6e-25 89.6 0.0 3.3e-14 52.2 0.0 3.2 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETS63487.1 - 2.5e-09 36.8 0.0 1.8e-07 30.7 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS63487.1 - 1.6e-08 34.7 0.0 3.9e-06 26.9 0.0 2.8 3 0 0 3 3 3 1 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 ETS63487.1 - 1.7e-08 34.1 0.1 0.0022 17.3 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS63487.1 - 4.3e-08 33.3 0.3 9.6e-08 32.1 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ETS63487.1 - 1.9e-05 24.0 0.0 0.11 11.7 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ETS63487.1 - 0.00015 21.1 0.1 0.00092 18.5 0.0 1.9 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 ETS63487.1 - 0.00018 21.2 0.4 0.0018 17.9 0.1 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETS63487.1 - 0.0018 18.8 0.2 0.024 15.2 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS63487.1 - 0.0064 15.6 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.14 ETS63487.1 - 0.012 14.4 0.1 0.019 13.7 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein FAD_oxidored PF12831.7 ETS63487.1 - 0.042 13.2 0.1 0.068 12.5 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ETS63487.1 - 0.05 12.8 0.4 0.12 11.6 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain Formyl_trans_N PF00551.19 ETS63488.1 - 5.1e-38 130.6 0.0 7.4e-38 130.1 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 ETS63488.1 - 6.1e-06 25.9 0.0 1.5e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 ACT domain ACT_6 PF13740.6 ETS63488.1 - 4e-05 23.5 0.0 0.00013 21.8 0.0 1.9 1 0 0 1 1 1 1 ACT domain Gtr1_RagA PF04670.12 ETS63489.1 - 4.5e-87 291.2 0.0 5.9e-87 290.8 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ETS63489.1 - 6.7e-06 26.3 0.0 1.4e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETS63489.1 - 1e-05 25.6 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ETS63489.1 - 1.3e-05 24.8 0.0 2.3e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETS63489.1 - 0.00067 19.2 0.0 0.0011 18.5 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family PRK PF00485.18 ETS63489.1 - 0.025 14.3 0.0 0.13 12.0 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.20 ETS63489.1 - 0.029 13.5 0.4 6.3 5.8 0.0 2.4 1 1 1 2 2 2 0 G-protein alpha subunit PduV-EutP PF10662.9 ETS63489.1 - 0.04 13.7 0.4 0.13 12.0 0.2 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ETS63489.1 - 0.043 14.2 0.1 0.11 12.9 0.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ETS63489.1 - 0.045 13.7 0.0 0.86 9.5 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 ETS63489.1 - 0.068 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ETS63489.1 - 0.078 12.5 0.0 0.67 9.4 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region Integrase_DNA PF02920.15 ETS63489.1 - 0.1 12.3 0.3 0.28 10.9 0.3 1.8 1 0 0 1 1 1 0 DNA binding domain of tn916 integrase Smg4_UPF3 PF03467.15 ETS63490.1 - 1.4e-60 204.3 0.1 1.4e-60 204.3 0.1 3.2 3 1 0 3 3 3 1 Smg-4/UPF3 family SYF2 PF08231.12 ETS63491.1 - 1.1e-47 162.4 17.8 2.1e-47 161.5 17.8 1.4 1 0 0 1 1 1 1 SYF2 splicing factor Cellulase PF00150.18 ETS63492.1 - 1.6e-12 47.5 0.3 1.6e-12 47.5 0.3 1.4 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) zf-C2H2_assoc PF16606.5 ETS63493.1 - 0.02 15.1 0.1 0.045 14.0 0.1 1.6 1 0 0 1 1 1 0 Unstructured conserved, between two C2H2-type zinc-fingers Response_reg PF00072.24 ETS63494.1 - 8.4e-21 74.2 0.0 1.9e-15 57.0 0.1 2.6 2 0 0 2 2 2 2 Response regulator receiver domain Ribosomal_S6 PF01250.17 ETS63495.1 - 4.1e-23 81.5 0.0 5e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 DEAD PF00270.29 ETS63496.1 - 1.3e-31 109.8 0.0 2.1e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS63496.1 - 1.3e-29 102.8 0.0 8.2e-29 100.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS63496.1 - 0.0033 17.4 0.0 0.0081 16.2 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ETS63496.1 - 0.052 13.8 0.1 1 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain SBF_like PF13593.6 ETS63496.1 - 0.057 12.7 0.0 0.089 12.1 0.0 1.2 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) EF_assoc_1 PF08355.12 ETS63497.1 - 0.00013 21.5 0.0 0.00023 20.7 0.0 1.4 1 0 0 1 1 1 1 EF hand associated OST-HTH PF12872.7 ETS63497.1 - 0.019 14.8 0.0 0.28 11.0 0.0 2.2 2 0 0 2 2 2 0 OST-HTH/LOTUS domain EF-hand_4 PF12763.7 ETS63497.1 - 0.046 13.7 0.0 0.14 12.1 0.0 1.9 1 1 2 3 3 3 0 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 ETS63497.1 - 0.064 13.7 0.6 0.16 12.5 0.6 1.7 1 1 0 1 1 1 0 EF-hand domain pair EF_assoc_2 PF08356.12 ETS63497.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 EF hand associated Mito_carr PF00153.27 ETS63499.1 - 1.4e-55 185.2 2.1 7.2e-18 64.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ndc80_HEC PF03801.13 ETS63500.1 - 4.7e-31 107.5 0.0 1.1e-29 103.0 0.0 2.3 2 0 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 ETS63500.1 - 1.6e-19 69.7 1.2 1.6e-19 69.7 1.2 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF5595) DUF2031 PF09592.10 ETS63500.1 - 0.086 12.4 8.5 0.16 11.4 8.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) Lzipper-MIP1 PF14389.6 ETS63500.1 - 1 9.7 10.9 0.12 12.7 4.1 2.9 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 GAS PF13851.6 ETS63500.1 - 3.6 6.9 39.4 0.62 9.4 2.4 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Glyco_hydro_5_C PF18564.1 ETS63501.1 - 4e-11 43.3 0.1 7.6e-10 39.2 0.0 2.8 3 0 0 3 3 3 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 ETS63501.1 - 5.4e-08 32.6 0.0 1.2e-05 24.9 0.0 2.7 3 0 0 3 3 3 2 Cellulase (glycosyl hydrolase family 5) Utp14 PF04615.13 ETS63502.1 - 7.3 5.0 23.0 8.7 4.8 23.0 1.0 1 0 0 1 1 1 0 Utp14 protein Peptidase_S64 PF08192.11 ETS63502.1 - 7.9 4.8 17.5 8.3 4.8 17.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 Abhydrolase_1 PF00561.20 ETS63503.1 - 7.8e-08 32.3 3.6 9.5e-08 32.0 0.3 2.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS63503.1 - 1.9e-07 30.6 0.1 0.00057 19.2 0.1 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ETS63503.1 - 0.072 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold RRM_1 PF00076.22 ETS63505.1 - 1.3e-12 47.3 0.0 1.5e-10 40.8 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS63505.1 - 0.0018 17.8 0.0 0.014 15.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GAS2 PF02187.17 ETS63506.1 - 1.8e-12 47.2 0.0 4.3e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain SPACA9 PF15120.6 ETS63506.1 - 0.082 12.7 0.3 0.18 11.6 0.3 1.5 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 adh_short PF00106.25 ETS63507.1 - 7.1e-44 149.6 0.0 8.3e-44 149.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63507.1 - 1.6e-34 119.5 0.0 2.1e-34 119.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63507.1 - 2e-11 44.2 0.0 3.5e-11 43.3 0.0 1.5 1 1 0 1 1 1 1 KR domain DUF1776 PF08643.10 ETS63507.1 - 3e-05 23.5 0.0 4.9e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 ETS63507.1 - 0.00012 21.6 0.1 0.00059 19.4 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ETS63507.1 - 0.0091 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 ETS63507.1 - 0.059 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase 3HCDH_N PF02737.18 ETS63507.1 - 0.077 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Fasciclin PF02469.22 ETS63508.1 - 6.8e-55 184.7 0.1 1.3e-12 48.1 0.0 6.9 7 1 0 7 7 7 6 Fasciclin domain DUF4381 PF14316.6 ETS63508.1 - 0.31 11.3 3.4 0.73 10.1 3.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) RINGv PF12906.7 ETS63509.1 - 4.6e-13 49.1 4.5 7.4e-13 48.4 4.5 1.3 1 0 0 1 1 1 1 RING-variant domain DUF983 PF06170.12 ETS63509.1 - 0.024 15.0 2.2 1.1 9.7 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF983) zf-RING_2 PF13639.6 ETS63509.1 - 0.16 12.3 2.0 0.26 11.6 2.0 1.3 1 0 0 1 1 1 0 Ring finger domain Radical_SAM_C PF16199.5 ETS63510.1 - 1.2e-31 108.6 0.1 3.3e-31 107.1 0.0 1.8 2 0 0 2 2 2 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ETS63510.1 - 4.8e-18 66.1 0.1 1.8e-17 64.3 0.1 1.9 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ETS63510.1 - 3.1e-08 33.8 0.1 6.5e-08 32.8 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETS63510.1 - 1.3e-05 25.1 0.0 2.6e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS63510.1 - 0.0054 17.1 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS63510.1 - 0.16 12.0 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein GCV_H PF01597.19 ETS63511.1 - 8.1e-44 148.4 0.1 9.5e-44 148.2 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 ETS63511.1 - 8.3e-05 22.5 0.0 0.00013 21.9 0.0 1.2 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 ETS63511.1 - 9.1e-05 22.2 0.2 0.00016 21.4 0.2 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 ETS63511.1 - 0.039 13.8 1.0 5.2 7.0 0.0 2.3 1 1 1 2 2 2 0 Biotin-lipoyl like Mito_carr PF00153.27 ETS63514.1 - 1.2e-41 140.5 3.0 2.8e-14 52.8 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF498 PF04430.14 ETS63515.1 - 5.4e-27 94.0 0.0 7.8e-27 93.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Amino_oxidase PF01593.24 ETS63515.1 - 0.19 11.0 0.0 0.27 10.5 0.0 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase zf-C2H2 PF00096.26 ETS63516.1 - 5.5e-22 76.9 43.9 6.5e-06 26.3 0.3 9.1 8 0 0 8 8 8 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETS63516.1 - 3.4e-19 68.3 45.1 5.9e-08 32.8 3.3 7.5 8 0 0 8 8 8 4 Zinc-finger double domain FOXP-CC PF16159.5 ETS63516.1 - 1.2e-09 38.6 32.4 0.0019 18.8 1.1 7.3 4 1 4 8 8 8 4 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ETS63516.1 - 3.3e-07 30.6 68.9 0.00012 22.6 0.8 9.9 11 0 0 11 11 8 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETS63516.1 - 2.9e-05 24.2 13.5 0.0027 17.9 0.1 4.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ETS63516.1 - 0.0006 19.5 11.5 0.33 10.7 0.5 5.2 4 0 0 4 4 4 2 zinc-finger C2H2-type Zn-C2H2_12 PF18112.1 ETS63516.1 - 0.0058 17.1 1.5 0.18 12.3 0.1 3.8 3 0 0 3 3 3 1 Autophagy receptor zinc finger-C2H2 domain zf-met PF12874.7 ETS63516.1 - 0.0077 16.6 5.4 0.2 12.1 0.4 3.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ETS63516.1 - 0.037 14.4 1.0 0.037 14.4 1.0 4.5 3 2 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 ETS63516.1 - 0.051 13.3 0.4 0.051 13.3 0.4 5.9 6 0 0 6 6 6 0 C2H2-type zinc-finger domain zf-C2H2_aberr PF17017.5 ETS63516.1 - 0.31 11.1 7.2 7.4 6.7 0.3 4.0 2 1 1 4 4 4 0 Aberrant zinc-finger zf_UBZ PF18439.1 ETS63516.1 - 7.9 6.2 13.1 4.8 6.9 1.0 4.6 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger RNA_polI_A34 PF08208.11 ETS63517.1 - 1.2e-10 41.9 4.6 1.2e-10 41.9 4.6 2.4 2 1 0 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 DUF4170 PF13773.6 ETS63517.1 - 0.12 12.6 0.2 0.21 11.8 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4170) adh_short PF00106.25 ETS63518.1 - 1.7e-18 66.8 1.5 1.4e-13 50.8 0.2 3.0 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63518.1 - 7.8e-12 45.3 9.1 6.3e-07 29.2 3.0 3.8 2 2 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63518.1 - 1.1e-05 25.4 5.9 0.02 14.8 5.9 2.4 1 1 0 1 1 1 1 KR domain SAPS PF04499.15 ETS63519.1 - 2.5 6.8 10.2 0.13 11.1 0.1 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein TFB6 PF17110.5 ETS63519.1 - 6.2 6.5 21.8 0.53 10.0 7.6 4.5 2 2 2 4 4 4 0 Subunit 11 of the general transcription factor TFIIH 2OG-FeII_Oxy_2 PF13532.6 ETS63520.1 - 1.7e-13 51.2 0.0 3.3e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RRM_1 PF00076.22 ETS63522.1 - 9.4e-24 83.0 0.0 2e-10 40.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.19 ETS63522.1 - 3.8e-21 73.5 0.0 0.00041 19.9 0.0 6.5 7 0 0 7 7 7 5 Pumilio-family RNA binding repeat RRM_occluded PF16842.5 ETS63522.1 - 4.5e-05 23.2 0.0 0.1 12.5 0.0 2.8 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_8 PF11835.8 ETS63522.1 - 0.0039 17.4 0.0 2.5 8.3 0.0 2.5 2 0 0 2 2 2 2 RRM-like domain DUF4523 PF15023.6 ETS63522.1 - 0.15 11.8 0.0 9.4 6.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) Lipase_3 PF01764.25 ETS63523.1 - 1.5e-07 31.4 0.0 3.3e-07 30.3 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 ETS63523.1 - 0.02 14.2 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS63523.1 - 8.9 6.8 9.0 0.31 11.6 1.7 2.3 2 2 0 2 2 2 0 Alpha/beta hydrolase family SNARE_assoc PF09335.11 ETS63524.1 - 7.3e-18 65.2 12.1 2.6e-17 63.4 9.4 2.4 2 0 0 2 2 2 1 SNARE associated Golgi protein Saf_2TM PF18303.1 ETS63524.1 - 0.032 13.8 0.5 0.032 13.8 0.5 2.0 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Coa1 PF08695.10 ETS63525.1 - 3e-27 94.7 0.1 4.3e-27 94.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Pkinase PF00069.25 ETS63526.1 - 3.3e-26 92.2 0.0 4.4e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63526.1 - 3.4e-13 49.5 0.0 5e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS63526.1 - 1.2e-07 30.8 1.8 2.9e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Presenilin PF01080.17 ETS63526.1 - 1.2 7.8 3.5 1.8 7.2 3.5 1.1 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ETS63527.1 - 2.1e-246 819.8 16.5 7.9e-246 817.9 16.5 2.0 1 1 0 1 1 1 1 DNA polymerase phi Pico_P2B PF01552.17 ETS63527.1 - 0.13 12.4 0.1 11 6.2 0.0 2.8 2 1 1 3 3 3 0 Picornavirus 2B protein Creb_binding PF09030.10 ETS63527.1 - 1.1 9.9 5.3 15 6.3 0.0 3.7 4 0 0 4 4 4 0 Creb binding p53-inducible11 PF14936.6 ETS63528.1 - 0.056 13.5 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 PGG PF13962.6 ETS63528.1 - 0.11 12.3 1.7 0.34 10.7 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function Collectrin PF16959.5 ETS63528.1 - 0.17 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Renal amino acid transporter NPR2 PF06218.11 ETS63529.1 - 1.5e-91 307.4 0.7 5.4e-40 137.5 0.0 5.3 4 2 1 5 5 5 4 Nitrogen permease regulator 2 Acetyltransf_1 PF00583.25 ETS63529.1 - 2.3e-11 44.0 0.0 4.3e-11 43.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family HhH-GPD PF00730.25 ETS63529.1 - 6.2e-10 39.5 0.0 1.7e-09 38.1 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Acetyltransf_10 PF13673.7 ETS63529.1 - 7.1e-05 22.7 0.0 0.00016 21.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS63529.1 - 0.00054 20.3 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETS63529.1 - 0.0026 17.7 0.0 0.006 16.5 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Peptidase_M28 PF04389.17 ETS63530.1 - 1.2e-34 119.8 0.2 1.9e-34 119.1 0.2 1.3 1 0 0 1 1 1 1 Peptidase family M28 GATase_4 PF13230.6 ETS63530.1 - 0.034 13.0 0.0 0.054 12.4 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II Homeodomain PF00046.29 ETS63531.1 - 1.8e-12 46.9 1.1 5.4e-12 45.4 1.1 1.9 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ETS63531.1 - 0.0046 16.8 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 Homeobox KN domain Sec63 PF02889.16 ETS63532.1 - 9.6e-71 237.9 0.0 1.5e-70 237.4 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 ETS63532.1 - 2.3e-36 125.2 0.6 3.8e-27 95.2 0.1 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase ApbA_C PF08546.11 ETS63532.1 - 9.5e-27 93.7 0.4 1.8e-25 89.5 0.0 2.6 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ETS63532.1 - 9.3e-21 74.1 0.0 1.3e-19 70.3 0.0 2.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA ResIII PF04851.15 ETS63532.1 - 1.8e-15 57.4 0.0 7.6e-10 39.0 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETS63532.1 - 9.6e-07 29.1 0.2 0.00011 22.5 0.0 4.0 3 1 0 3 3 3 1 Helicase conserved C-terminal domain T2SSE PF00437.20 ETS63532.1 - 6.9e-05 22.0 0.1 0.08 12.0 0.0 3.8 4 0 0 4 4 4 1 Type II/IV secretion system protein AAA_22 PF13401.6 ETS63532.1 - 0.00012 22.4 3.4 0.079 13.2 0.2 3.5 3 1 0 3 3 2 2 AAA domain Helicase_PWI PF18149.1 ETS63532.1 - 0.001 19.2 0.0 0.0039 17.3 0.0 2.0 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_7 PF12775.7 ETS63532.1 - 0.0015 18.1 0.0 0.075 12.5 0.0 2.7 3 0 0 3 3 3 1 P-loop containing dynein motor region IstB_IS21 PF01695.17 ETS63532.1 - 0.0029 17.3 0.2 2.7 7.7 0.0 2.9 3 0 0 3 3 3 2 IstB-like ATP binding protein AAA_29 PF13555.6 ETS63532.1 - 0.014 15.1 0.0 0.072 12.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain Synaptobrevin PF00957.21 ETS63533.1 - 9.8e-25 86.2 0.1 1.3e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ETS63533.1 - 3.1e-19 68.8 0.0 5.5e-19 68.0 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Lactonase PF10282.9 ETS63536.1 - 2.6e-14 53.3 0.6 6.4e-13 48.7 0.1 2.2 2 0 0 2 2 2 2 Lactonase, 7-bladed beta-propeller Tom37 PF10568.9 ETS63537.1 - 3.2e-16 59.8 0.2 6.2e-16 58.8 0.2 1.5 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 ETS63537.1 - 1.8e-05 24.4 0.0 4e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETS63537.1 - 0.0015 18.5 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain SDA1 PF05285.12 ETS63537.1 - 2.3 7.6 17.3 3.1 7.1 17.3 1.2 1 0 0 1 1 1 0 SDA1 TFIIA PF03153.13 ETS63537.1 - 3.3 7.6 11.8 4.9 7.0 11.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit tRNA_Me_trans PF03054.16 ETS63538.1 - 5.3e-106 354.4 0.0 1.2e-105 353.2 0.0 1.5 1 1 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 ETS63538.1 - 0.013 14.6 0.1 0.24 10.5 0.0 2.2 2 0 0 2 2 2 0 NAD synthase QueC PF06508.13 ETS63538.1 - 0.2 11.1 0.0 1.2 8.5 0.0 2.0 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC PTCB-BRCT PF12738.7 ETS63539.1 - 1.5e-32 111.3 0.0 7.4e-12 45.0 0.0 4.6 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 ETS63539.1 - 1.5e-29 102.2 0.0 5.8e-10 39.4 0.0 5.5 5 0 0 5 5 5 4 BRCA1 C Terminus (BRCT) domain CENP-C_C PF11699.8 ETS63539.1 - 6.1e-29 100.1 0.0 1.1e-28 99.3 0.0 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like BRCT_2 PF16589.5 ETS63539.1 - 2.2e-11 44.0 0.0 0.36 11.3 0.0 5.5 5 0 0 5 5 5 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ETS63539.1 - 5.4e-05 23.4 0.0 5.4 7.4 0.0 5.0 5 0 0 5 5 5 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 ETS63539.1 - 0.00076 19.3 0.0 0.3 11.0 0.0 3.2 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain Cupin_2 PF07883.11 ETS63539.1 - 0.008 15.9 0.0 0.025 14.3 0.0 1.9 2 0 0 2 2 2 1 Cupin domain AT_hook PF02178.19 ETS63539.1 - 2.9 8.1 13.0 0.17 11.9 4.5 3.6 2 0 0 2 2 2 0 AT hook motif CLTH PF10607.9 ETS63540.1 - 1.7e-18 67.0 0.0 2.4e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ETS63540.1 - 0.0073 16.2 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 LisH DUF3194 PF11419.8 ETS63540.1 - 0.05 14.0 0.4 0.26 11.7 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3194) TipE PF16972.5 ETS63540.1 - 9.4 5.3 10.3 4 6.5 7.8 1.8 1 1 0 1 1 1 0 Na+ channel auxiliary subunit TipE WD40 PF00400.32 ETS63541.1 - 4.6e-13 49.4 6.1 0.03 15.2 0.2 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETS63541.1 - 0.13 10.9 2.6 8.1 4.9 0.4 2.9 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Brix PF04427.18 ETS63542.1 - 8.7e-43 146.7 0.0 1.4e-42 146.0 0.0 1.4 1 0 0 1 1 1 1 Brix domain TFIIA PF03153.13 ETS63542.1 - 0.00029 21.0 4.9 0.00044 20.4 4.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 ETS63542.1 - 2.7 7.3 19.8 3.9 6.7 19.8 1.2 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 ETS63542.1 - 3.2 7.0 18.3 5 6.4 18.3 1.3 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETS63542.1 - 6.3 4.9 25.4 8.4 4.5 25.4 1.1 1 0 0 1 1 1 0 Nop14-like family Peptidase_S28 PF05577.12 ETS63543.1 - 1.2e-39 136.4 0.0 2e-35 122.5 0.0 2.6 2 1 0 2 2 2 2 Serine carboxypeptidase S28 Ras PF00071.22 ETS63544.1 - 2.1e-52 177.0 0.0 2.7e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS63544.1 - 2.2e-18 66.6 0.0 3.2e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS63544.1 - 5.6e-06 25.9 0.0 9e-06 25.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family zf-C3HC4_3 PF13920.6 ETS63545.1 - 0.00033 20.5 6.8 0.00054 19.8 6.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS63545.1 - 0.067 13.1 11.1 0.1 12.5 11.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TAF4 PF05236.14 ETS63545.1 - 0.29 10.8 6.9 0.65 9.7 6.9 1.6 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Pex2_Pex12 PF04757.14 ETS63546.1 - 1.5e-43 149.0 0.5 1.9e-43 148.7 0.5 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 ETS63546.1 - 8.6e-05 22.3 0.8 0.00013 21.8 0.8 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS63546.1 - 0.0013 19.0 1.0 0.0024 18.2 1.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETS63546.1 - 0.0016 18.3 2.0 0.003 17.4 2.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS63546.1 - 0.013 15.3 0.9 0.021 14.7 0.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS63546.1 - 0.11 12.6 3.4 0.19 11.8 3.4 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETS63546.1 - 0.14 12.3 4.2 0.24 11.6 4.2 1.3 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETS63546.1 - 0.33 10.8 3.1 3.3 7.6 3.0 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 UCH PF00443.29 ETS63547.1 - 3.1e-38 131.7 0.0 4.4e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ETS63547.1 - 1.2e-24 86.4 7.4 5.7e-19 68.2 1.7 2.8 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 ETS63547.1 - 1.8e-24 85.3 3.2 1.6e-23 82.2 0.2 2.5 2 0 0 2 2 2 1 Variant UBP zinc finger UBA PF00627.31 ETS63547.1 - 4.2e-20 71.3 0.7 6.7e-09 35.5 0.3 2.5 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 ETS63547.1 - 7.6e-11 42.2 0.0 5.1e-10 39.5 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_4 PF14555.6 ETS63547.1 - 0.017 14.9 0.1 0.033 14.0 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain Ribosomal_L5_C PF00673.21 ETS63547.1 - 0.023 14.8 0.0 0.06 13.5 0.0 1.6 1 0 0 1 1 1 0 ribosomal L5P family C-terminus PalH PF08733.10 ETS63548.1 - 0.41 9.6 2.7 1.1 8.2 2.7 1.6 1 1 0 1 1 1 0 PalH/RIM21 Met_10 PF02475.16 ETS63549.1 - 2.9e-53 180.6 0.0 3.5e-46 157.5 0.0 2.1 2 0 0 2 2 2 2 Met-10+ like-protein PIG-L PF02585.17 ETS63550.1 - 1.6e-23 83.7 0.3 2.2e-23 83.3 0.3 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Chorismate_bind PF00425.18 ETS63551.1 - 1.4e-86 290.3 0.0 2e-86 289.7 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ETS63551.1 - 9.3e-27 94.0 0.0 2.9e-26 92.4 0.0 1.9 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Pox_A12 PF04651.13 ETS63551.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 Poxvirus A12 protein PRP21_like_P PF12230.8 ETS63552.1 - 3.7e-42 144.6 2.2 9.4e-42 143.3 1.1 2.1 2 0 0 2 2 2 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 ETS63552.1 - 1.9e-30 104.6 2.2 2.5e-14 53.0 0.1 2.5 2 0 0 2 2 2 2 Surp module ubiquitin PF00240.23 ETS63552.1 - 0.0076 16.0 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Toprim_Crpt PF13342.6 ETS63552.1 - 0.69 9.9 2.7 6.7 6.8 0.3 2.5 2 0 0 2 2 2 0 C-terminal repeat of topoisomerase AP_endonuc_2 PF01261.24 ETS63554.1 - 5e-30 104.5 0.0 8.9e-30 103.7 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel WD40 PF00400.32 ETS63556.1 - 3.4e-13 49.8 3.6 0.001 19.8 0.1 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63556.1 - 1e-06 29.0 0.1 0.004 17.4 0.0 3.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Asn_synthase PF00733.21 ETS63557.1 - 3.2e-91 306.6 1.2 8.7e-56 190.1 0.0 3.1 2 1 1 3 3 3 3 Asparagine synthase GATase_7 PF13537.6 ETS63557.1 - 1.8e-37 128.0 0.0 2.9e-37 127.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ETS63557.1 - 3e-30 105.1 0.0 5.9e-30 104.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 ETS63557.1 - 4.1e-05 23.1 0.0 0.00011 21.7 0.0 1.7 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 ETS63557.1 - 0.023 13.8 0.0 0.037 13.1 0.0 1.3 1 0 0 1 1 1 0 NAD synthase DUF1776 PF08643.10 ETS63558.1 - 2.2e-05 24.0 0.0 0.2 11.0 0.0 2.3 2 0 0 2 2 2 2 Fungal family of unknown function (DUF1776) adh_short PF00106.25 ETS63558.1 - 0.0048 16.4 0.0 0.093 12.2 0.0 2.3 3 0 0 3 3 3 1 short chain dehydrogenase PRIMA1 PF16101.5 ETS63558.1 - 0.18 11.9 2.6 0.62 10.1 2.6 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DEAD PF00270.29 ETS63559.1 - 1.1e-32 113.2 0.0 2.9e-31 108.6 0.0 2.7 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS63559.1 - 2.5e-23 82.5 0.0 2.8e-12 47.0 0.0 2.9 3 1 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ETS63559.1 - 0.025 14.6 0.0 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit BATS PF06968.13 ETS63560.1 - 1.1e-18 67.2 0.3 2.9e-18 65.8 0.0 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 ETS63560.1 - 1.4e-14 54.9 0.1 2.7e-14 53.9 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily FeoB_associated PF12669.7 ETS63560.1 - 0.82 10.1 2.8 2.2 8.8 2.8 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Zn_clus PF00172.18 ETS63561.1 - 7.3e-10 38.8 26.5 5.1e-08 32.9 8.3 2.9 2 1 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain F-box-like PF12937.7 ETS63563.1 - 0.011 15.6 1.4 0.13 12.1 0.2 2.7 2 0 0 2 2 2 0 F-box-like RL10P_insert PF17777.1 ETS63564.1 - 2.7e-21 75.3 0.1 4.1e-21 74.8 0.1 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 ETS63564.1 - 1.2e-18 67.0 0.0 2.3e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L10 NOA36 PF06524.12 ETS63564.1 - 1.1 8.6 15.0 1.6 8.0 15.0 1.2 1 0 0 1 1 1 0 NOA36 protein S-antigen PF05756.11 ETS63564.1 - 1.7 9.0 5.4 3.8 8.0 5.4 1.6 1 0 0 1 1 1 0 S-antigen protein RRN3 PF05327.11 ETS63564.1 - 5.7 5.4 5.4 7.1 5.0 5.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAM176 PF14851.6 ETS63564.1 - 6.6 6.4 7.8 14 5.4 7.8 1.5 1 0 0 1 1 1 0 FAM176 family HEAT_2 PF13646.6 ETS63565.1 - 2.2e-26 92.1 2.6 8.1e-14 51.8 1.5 2.7 2 1 0 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 ETS63565.1 - 2.6e-19 67.9 1.2 0.00061 20.2 0.0 6.8 7 0 0 7 7 7 4 PBS lyase HEAT-like repeat HEAT PF02985.22 ETS63565.1 - 8.7e-15 53.6 3.7 0.087 13.1 0.0 6.4 7 0 0 7 7 7 4 HEAT repeat Arm PF00514.23 ETS63565.1 - 0.00046 20.1 0.1 1.8 8.7 0.0 4.0 3 1 1 4 4 4 2 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 ETS63565.1 - 0.0032 17.5 0.2 2.6 8.1 0.0 3.5 2 2 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Cohesin_HEAT PF12765.7 ETS63565.1 - 0.0037 17.5 2.3 0.012 15.9 0.1 3.0 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion UPF0147 PF03685.13 ETS63565.1 - 0.0079 16.2 0.3 2.5 8.2 0.0 3.3 3 1 0 3 3 3 1 Uncharacterised protein family (UPF0147) HEAT_EZ PF13513.6 ETS63565.1 - 0.0081 16.6 4.3 18 6.0 0.1 4.7 2 2 3 5 5 5 0 HEAT-like repeat IFRD PF05004.13 ETS63565.1 - 0.025 13.7 0.7 9.4 5.2 0.0 3.1 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) SIMPL PF04402.14 ETS63565.1 - 0.082 13.4 2.5 0.16 12.4 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF541) CLTH PF10607.9 ETS63566.1 - 1.9e-30 105.7 0.0 2.6e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ETS63566.1 - 2.9e-09 36.5 1.6 4.3e-09 36.0 0.0 2.2 3 0 0 3 3 3 1 LisH DWNN PF08783.11 ETS63567.1 - 6.5e-35 119.3 0.0 1.2e-34 118.4 0.0 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 ETS63567.1 - 2.1e-10 40.2 4.8 3.6e-10 39.4 4.8 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ETS63567.1 - 6.1e-06 26.1 0.9 1.3e-05 25.0 0.9 1.6 1 0 0 1 1 1 1 Zinc knuckle U-box PF04564.15 ETS63567.1 - 0.00011 22.3 0.1 0.0077 16.4 0.0 2.5 1 1 1 2 2 2 1 U-box domain zf-CCHC_3 PF13917.6 ETS63567.1 - 0.00035 20.5 0.7 0.0013 18.6 0.7 2.0 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 ETS63567.1 - 0.012 15.4 10.5 0.012 15.4 10.5 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-CCHC_5 PF14787.6 ETS63567.1 - 0.013 15.2 0.5 0.04 13.6 0.5 1.8 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger TetR_C_23 PF17931.1 ETS63567.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain zf-RING_2 PF13639.6 ETS63567.1 - 0.24 11.8 12.3 0.52 10.7 12.3 1.6 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 ETS63567.1 - 2.6 8.0 15.5 4.8 7.1 15.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETS63567.1 - 2.9 8.1 13.8 6.7 7.0 13.8 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Trm112p PF03966.16 ETS63567.1 - 5 7.8 6.9 13 6.5 6.9 1.6 1 0 0 1 1 1 0 Trm112p-like protein zf-C3HC4_2 PF13923.6 ETS63567.1 - 5.5 6.9 21.7 0.064 13.1 13.9 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) LCAT PF02450.15 ETS63568.1 - 4.1e-91 306.1 0.0 1.1e-90 304.6 0.0 1.6 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase Lipase_2 PF01674.18 ETS63568.1 - 0.078 12.5 0.0 0.25 10.8 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 2) MOR2-PAG1_N PF14222.6 ETS63569.1 - 4.6e-128 428.6 0.0 7.9e-128 427.8 0.0 1.4 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 ETS63569.1 - 2.1e-93 312.8 0.1 2e-91 306.4 0.0 3.4 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 ETS63569.1 - 2.6e-31 108.2 4.5 3.8e-14 51.4 0.0 4.1 3 1 1 4 4 4 4 Cell morphogenesis central region HEAT_EZ PF13513.6 ETS63569.1 - 0.011 16.2 0.1 5.1 7.7 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat Ecm29 PF13001.7 ETS63569.1 - 0.034 12.8 0.3 3.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Proteasome stabiliser Laminin_I PF06008.14 ETS63569.1 - 0.12 12.1 0.3 16 5.0 0.1 2.3 2 0 0 2 2 2 0 Laminin Domain I HEAT_2 PF13646.6 ETS63569.1 - 0.22 11.9 9.0 1.8 9.0 0.0 6.3 7 0 0 7 7 7 0 HEAT repeats Acid_PPase PF12689.7 ETS63570.1 - 1.1e-55 188.1 0.0 1.3e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase Hydrolase PF00702.26 ETS63570.1 - 0.0043 17.4 0.0 0.06 13.6 0.0 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF903 PF06004.12 ETS63570.1 - 0.024 14.5 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) HAD_2 PF13419.6 ETS63570.1 - 0.19 11.8 0.0 1.5 8.9 0.0 2.0 1 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Pex2_Pex12 PF04757.14 ETS63571.1 - 1.7e-33 116.1 5.3 2.5e-33 115.6 5.3 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 ETS63571.1 - 0.00029 20.6 0.8 0.0092 15.8 0.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS63571.1 - 0.0028 17.7 0.1 0.059 13.4 0.0 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETS63571.1 - 0.0042 16.9 2.8 0.0087 15.9 0.8 2.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS63571.1 - 0.023 15.0 0.4 0.75 10.2 0.1 2.3 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 ETS63571.1 - 0.36 10.8 2.6 0.8 9.7 0.9 2.2 2 1 0 2 2 2 0 zinc-RING finger domain RIX1 PF08167.12 ETS63572.1 - 9.8e-40 136.3 4.0 7.9e-38 130.1 2.4 2.5 2 0 0 2 2 2 2 rRNA processing/ribosome biogenesis Qn_am_d_aIII PF09099.10 ETS63572.1 - 0.0064 16.8 1.6 0.71 10.3 0.3 2.8 2 0 0 2 2 2 2 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Sec10 PF07393.11 ETS63573.1 - 2.2e-277 922.2 0.0 2.8e-277 921.9 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF1664 PF07889.12 ETS63573.1 - 0.038 14.0 0.7 0.1 12.6 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ETS63573.1 - 0.089 11.7 0.2 0.16 10.8 0.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Spectrin PF00435.21 ETS63573.1 - 0.091 13.3 0.1 0.39 11.2 0.1 2.2 1 0 0 1 1 1 0 Spectrin repeat V-SNARE PF05008.15 ETS63573.1 - 0.11 12.9 0.1 0.55 10.6 0.0 2.3 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Filament PF00038.21 ETS63573.1 - 0.18 11.4 0.5 0.33 10.5 0.5 1.4 1 0 0 1 1 1 0 Intermediate filament protein CTD_bind PF04818.13 ETS63573.1 - 0.23 12.3 0.8 4.8 8.1 0.0 3.3 4 0 0 4 4 4 0 RNA polymerase II-binding domain. Dor1 PF04124.12 ETS63573.1 - 0.36 9.5 1.3 0.69 8.5 1.3 1.4 1 0 0 1 1 1 0 Dor1-like family IFT20 PF14931.6 ETS63573.1 - 0.45 10.7 1.9 0.53 10.5 0.4 1.9 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 Glyco_hydro_16 PF00722.21 ETS63574.1 - 2.8e-34 118.1 4.4 4.1e-34 117.6 4.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 ETS63574.1 - 0.0002 21.8 12.6 0.00048 20.6 12.6 1.6 1 0 0 1 1 1 1 Chitin recognition protein DUF1080 PF06439.11 ETS63574.1 - 0.017 15.2 0.6 0.026 14.6 0.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) DUF4660 PF15559.6 ETS63574.1 - 0.25 11.7 1.6 0.87 9.9 0.1 2.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4660) Sld5 PF05916.11 ETS63575.1 - 5.5e-12 46.1 0.1 9.5e-12 45.3 0.1 1.4 1 1 0 1 1 1 1 GINS complex protein Pox_A3L PF05288.11 ETS63575.1 - 0.12 12.4 0.0 0.69 9.9 0.0 2.1 2 0 0 2 2 2 0 Poxvirus A3L Protein Flot PF15975.5 ETS63576.1 - 7.9 6.7 8.7 0.92 9.7 0.9 2.5 2 0 0 2 2 2 0 Flotillin TPR_2 PF07719.17 ETS63577.1 - 9.9e-18 62.8 12.5 0.056 13.6 0.1 11.1 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETS63577.1 - 1.1e-17 64.4 6.7 0.00046 20.8 0.1 8.1 9 0 0 9 9 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETS63577.1 - 3e-15 55.1 4.9 0.51 10.7 0.1 8.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETS63577.1 - 3.7e-13 49.8 12.4 4.7e-05 23.8 0.4 7.9 8 1 1 9 9 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETS63577.1 - 8.6e-12 44.4 8.1 0.26 11.2 0.1 9.5 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETS63577.1 - 1e-10 41.8 18.9 3.7e-05 23.9 0.8 7.1 6 2 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETS63577.1 - 8.3e-10 38.2 0.0 0.022 14.4 0.0 4.7 4 0 0 4 4 4 2 TPR repeat TPR_6 PF13174.6 ETS63577.1 - 2.1e-07 31.1 6.9 1.7 9.4 0.0 8.6 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETS63577.1 - 2.6e-07 30.9 21.5 0.0016 19.1 1.4 9.7 8 2 2 10 10 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETS63577.1 - 2.7e-06 27.4 0.1 0.13 12.7 0.0 4.9 6 0 0 6 6 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 ETS63577.1 - 0.00016 21.0 5.4 0.01 15.1 1.4 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS63577.1 - 0.00018 21.6 7.0 0.045 13.9 0.1 4.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETS63577.1 - 0.00046 20.0 9.2 7 6.9 0.1 7.8 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETS63577.1 - 0.00083 19.6 4.7 0.92 9.9 0.0 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS63577.1 - 0.012 15.8 5.4 1.1 9.5 1.8 4.5 4 2 1 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Vps39_1 PF10366.9 ETS63577.1 - 0.16 12.3 0.1 6.4 7.1 0.0 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Alkyl_sulf_dimr PF14863.6 ETS63577.1 - 0.23 11.9 1.3 18 5.8 0.1 2.9 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Nup88 PF10168.9 ETS63578.1 - 3.7e-18 64.7 0.0 5.2e-15 54.3 0.0 3.0 3 0 0 3 3 3 3 Nuclear pore component Sec1 PF00995.23 ETS63579.1 - 8.3e-121 405.0 0.0 9.6e-121 404.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF4266 PF14086.6 ETS63579.1 - 1.4 9.9 3.2 28 5.8 0.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4266) SCHIP-1 PF10148.9 ETS63580.1 - 0.12 12.0 0.5 0.16 11.6 0.5 1.1 1 0 0 1 1 1 0 Schwannomin-interacting protein 1 Pkinase PF00069.25 ETS63581.1 - 1.4e-34 119.7 0.0 2.9e-20 72.7 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63581.1 - 7.5e-17 61.5 0.0 2.9e-15 56.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase UQ_con PF00179.26 ETS63582.1 - 5.4e-45 152.5 0.0 6.1e-45 152.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Syntaxin-18_N PF10496.9 ETS63583.1 - 3e-15 56.2 0.9 3.6e-14 52.8 0.0 2.9 3 0 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus DUF5089 PF17002.5 ETS63583.1 - 0.012 15.5 0.9 0.03 14.2 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) SNARE PF05739.19 ETS63583.1 - 0.022 14.8 0.0 0.097 12.7 0.0 2.1 2 0 0 2 2 2 0 SNARE domain Glyco_transf_22 PF03901.17 ETS63584.1 - 4.5e-32 111.8 6.7 6.1e-32 111.4 6.7 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family XAP5 PF04921.14 ETS63585.1 - 1e-84 284.3 7.4 1e-84 284.3 7.4 2.0 1 1 1 2 2 2 1 XAP5, circadian clock regulator Gemin6 PF06372.12 ETS63585.1 - 0.28 10.7 1.4 7.3 6.1 0.2 2.3 2 0 0 2 2 2 0 Gemin6 protein ACT_7 PF13840.6 ETS63586.1 - 1.4e-15 56.8 0.0 4e-15 55.3 0.0 1.7 2 0 0 2 2 2 1 ACT domain AA_permease PF00324.21 ETS63588.1 - 2.2e-134 448.7 42.6 2.7e-134 448.3 42.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS63588.1 - 4.8e-41 141.0 45.2 6.5e-41 140.5 45.2 1.1 1 0 0 1 1 1 1 Amino acid permease Flavin_Reduct PF01613.18 ETS63591.1 - 1.6e-18 67.2 0.1 2.4e-18 66.7 0.1 1.1 1 0 0 1 1 1 1 Flavin reductase like domain Methyltransf_23 PF13489.6 ETS63592.1 - 1.1e-14 54.7 0.5 1.6e-14 54.1 0.5 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS63592.1 - 2e-14 54.1 0.0 4e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63592.1 - 1.6e-13 51.1 0.1 4.5e-13 49.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS63592.1 - 7.8e-13 48.9 0.1 2.4e-12 47.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS63592.1 - 2.3e-10 40.5 0.0 3.5e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS63592.1 - 1.1e-05 25.0 0.1 2.5e-05 23.9 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 ETS63592.1 - 3.1e-05 23.2 0.0 0.00029 20.0 0.0 2.0 1 1 0 1 1 1 1 DREV methyltransferase DUF938 PF06080.12 ETS63592.1 - 0.00011 22.0 0.1 0.00016 21.5 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Ubie_methyltran PF01209.18 ETS63592.1 - 0.00012 21.5 0.0 0.00019 20.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family RrnaAD PF00398.20 ETS63592.1 - 0.0032 16.6 0.0 0.0056 15.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase NodS PF05401.11 ETS63592.1 - 0.0063 16.2 0.1 0.01 15.5 0.1 1.3 1 0 0 1 1 1 1 Nodulation protein S (NodS) DRE2_N PF16803.5 ETS63592.1 - 0.015 15.5 0.0 0.03 14.6 0.0 1.5 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus NPV_P10 PF05531.12 ETS63592.1 - 0.022 15.2 0.2 0.049 14.1 0.2 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein TehB PF03848.14 ETS63592.1 - 0.024 14.1 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB VWA_2 PF13519.6 ETS63592.1 - 0.033 14.9 0.1 0.099 13.3 0.1 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain Cons_hypoth95 PF03602.15 ETS63592.1 - 0.036 13.7 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 SelP_N PF04592.14 ETS63592.1 - 3.4 7.0 13.6 14 5.0 13.3 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region TFCD_C PF12612.8 ETS63593.1 - 5.5e-39 134.0 0.3 6.8e-37 127.1 0.0 3.9 4 0 0 4 4 4 1 Tubulin folding cofactor D C terminal RTP1_C1 PF10363.9 ETS63593.1 - 0.0016 18.6 0.2 0.015 15.4 0.0 2.8 3 0 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETS63593.1 - 0.011 16.3 0.2 2.1 9.0 0.0 4.0 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ETS63593.1 - 0.026 14.7 22.8 0.031 14.5 0.0 8.3 8 0 0 8 8 8 0 HEAT repeat DUF3648 PF12364.8 ETS63593.1 - 0.15 12.2 0.7 2.8 8.1 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3648) HEAT_PBS PF03130.16 ETS63593.1 - 0.19 12.5 0.0 0.19 12.5 0.0 6.9 8 0 0 8 8 8 0 PBS lyase HEAT-like repeat TAF6_C PF07571.13 ETS63593.1 - 0.32 11.3 3.0 25 5.3 0.0 4.2 6 0 0 6 6 6 0 TAF6 C-terminal HEAT repeat domain HEAT_2 PF13646.6 ETS63593.1 - 0.39 11.1 0.0 0.39 11.1 0.0 6.5 4 2 0 5 5 5 0 HEAT repeats Lipase_3 PF01764.25 ETS63594.1 - 1.1e-17 64.2 0.0 3.3e-14 53.0 0.0 2.4 2 0 0 2 2 2 2 Lipase (class 3) Hydrolase_4 PF12146.8 ETS63594.1 - 0.039 13.2 0.0 0.079 12.2 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 SLX9 PF15341.6 ETS63595.1 - 6.4e-20 71.9 8.3 1e-19 71.2 8.3 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 Astro_capsid_p PF12226.8 ETS63595.1 - 0.01 15.0 0.4 0.013 14.7 0.4 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF4335 PF14233.6 ETS63595.1 - 0.041 13.8 0.1 0.056 13.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) RNA_pol_3_Rpc31 PF11705.8 ETS63595.1 - 0.052 13.8 6.7 0.094 13.0 6.7 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 p450 PF00067.22 ETS63596.1 - 3.2e-53 181.1 0.0 3.9e-53 180.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Mannosyl_trans PF05007.13 ETS63597.1 - 3.3e-59 200.9 19.5 2.3e-57 194.8 12.0 2.5 3 0 0 3 3 3 2 Mannosyltransferase (PIG-M) UPF0061 PF02696.14 ETS63598.1 - 2.1e-95 320.2 0.0 3.1e-95 319.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family GNAT_acetyltr_2 PF13718.6 ETS63598.1 - 0.12 11.7 0.1 0.12 11.7 0.1 2.2 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Cupin_8 PF13621.6 ETS63599.1 - 8.9e-23 81.3 0.4 1.3e-22 80.8 0.4 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ETS63599.1 - 3.1e-15 56.6 0.7 5.9e-15 55.7 0.7 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase GPI PF06560.11 ETS63599.1 - 0.028 13.7 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Cupin_2 PF07883.11 ETS63599.1 - 0.028 14.1 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 Cupin domain Peptidase_C48 PF02902.19 ETS63600.1 - 1.3e-38 133.0 0.0 8.6e-36 123.8 0.0 2.4 2 0 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain Nitr_red_bet_C PF14711.6 ETS63600.1 - 0.056 13.1 0.6 6.7 6.5 0.1 2.6 2 0 0 2 2 2 0 Respiratory nitrate reductase beta C-terminal ANAPC9 PF12856.7 ETS63600.1 - 0.78 9.9 0.0 0.78 9.9 0.0 3.1 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 9 SGT1 PF07093.11 ETS63601.1 - 2.7e-76 257.3 10.3 1.6e-53 182.1 0.1 3.1 3 0 0 3 3 3 2 SGT1 protein ANAPC4 PF12896.7 ETS63601.1 - 0.0059 16.1 0.2 2.8 7.4 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 4 PG_binding_2 PF08823.11 ETS63601.1 - 0.031 14.6 0.0 0.11 12.9 0.0 1.9 1 0 0 1 1 1 0 Putative peptidoglycan binding domain DIL PF01843.19 ETS63602.1 - 8.9e-30 103.0 1.2 2.1e-29 101.9 1.2 1.7 1 0 0 1 1 1 1 DIL domain Ank_4 PF13637.6 ETS63602.1 - 1.5e-11 44.6 0.0 3e-05 24.5 0.0 3.7 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS63602.1 - 7.8e-11 42.4 0.0 6e-10 39.6 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETS63602.1 - 4.6e-08 32.7 0.0 0.00044 20.5 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETS63602.1 - 4e-07 30.2 0.0 5.4e-05 23.4 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETS63602.1 - 0.00032 21.0 0.0 0.04 14.3 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DSHCT PF08148.12 ETS63604.1 - 4.4e-49 166.3 0.4 1.2e-48 164.9 0.4 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 ETS63604.1 - 3.3e-37 127.3 0.1 6.5e-37 126.3 0.1 1.5 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 ETS63604.1 - 7.4e-27 94.9 0.1 1.3e-26 94.1 0.1 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 ETS63604.1 - 1.4e-19 70.5 0.0 2.8e-19 69.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETS63604.1 - 5.7e-07 29.7 0.0 1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETS63604.1 - 6.2e-06 26.5 0.0 1.9e-05 25.0 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ETS63604.1 - 0.14 12.5 0.0 0.4 10.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain DUF952 PF06108.12 ETS63605.1 - 2.3e-15 56.3 0.0 3e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Mit_KHE1 PF10173.9 ETS63606.1 - 1.9e-57 194.5 0.8 4.3e-57 193.3 0.1 1.8 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related Lectin_C PF00059.21 ETS63606.1 - 0.053 14.3 0.0 0.11 13.3 0.0 1.5 1 0 0 1 1 1 0 Lectin C-type domain DND1_DSRM PF14709.7 ETS63606.1 - 1.6 9.0 3.6 25 5.2 0.0 3.1 3 0 0 3 3 3 0 double strand RNA binding domain from DEAD END PROTEIN 1 PCP_red PF08369.10 ETS63606.1 - 2.7 8.3 6.0 0.99 9.7 0.3 2.5 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit Nbl1_Borealin_N PF10444.9 ETS63607.1 - 2.7e-15 55.8 2.3 5.1e-15 54.9 2.3 1.5 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal CEP63 PF17045.5 ETS63607.1 - 0.01 15.8 1.6 0.015 15.2 1.5 1.4 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa LMBR1 PF04791.16 ETS63607.1 - 0.61 8.9 2.1 0.74 8.7 2.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Dfp1_Him1_M PF08630.10 ETS63608.1 - 5.6e-34 117.1 0.1 1.4e-33 115.8 0.1 1.7 1 0 0 1 1 1 1 Dfp1/Him1, central region zf-DBF PF07535.12 ETS63608.1 - 2.8e-19 68.9 0.8 5.3e-19 68.0 0.8 1.5 1 0 0 1 1 1 1 DBF zinc finger BRCT PF00533.26 ETS63608.1 - 0.0092 16.3 0.0 0.018 15.4 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Arf PF00025.21 ETS63610.1 - 2.5e-79 264.8 0.1 2.8e-79 264.6 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETS63610.1 - 1.3e-14 54.4 0.0 1.8e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETS63610.1 - 3.6e-14 52.6 0.0 4.5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ETS63610.1 - 7.8e-13 48.3 0.0 8.3e-13 48.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ETS63610.1 - 8.7e-13 48.1 1.2 5.9e-09 35.5 0.4 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ETS63610.1 - 2e-10 40.4 0.0 2.5e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS63610.1 - 2.7e-06 27.5 0.0 4.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ETS63610.1 - 0.0067 15.8 0.4 0.021 14.1 0.1 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase GTP_CH_N PF12471.8 ETS63611.1 - 9.5e-89 296.3 0.0 1.4e-88 295.7 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 ETS63611.1 - 4.6e-13 49.1 0.0 7.1e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II PA PF02225.22 ETS63611.1 - 0.079 13.0 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 PA domain DUF5082 PF16888.5 ETS63611.1 - 0.21 11.9 0.1 0.35 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Methyltransf_34 PF11312.8 ETS63613.1 - 0.084 12.1 0.2 0.14 11.4 0.2 1.3 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase WSC PF01822.19 ETS63615.1 - 0.048 13.9 2.4 0.12 12.6 2.4 1.7 1 0 0 1 1 1 0 WSC domain Cadherin_C PF01049.17 ETS63615.1 - 0.15 12.4 1.0 25 5.2 0.0 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic region Thg1 PF04446.12 ETS63616.1 - 3.3e-47 159.6 0.0 4.9e-47 159.1 0.0 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 ETS63616.1 - 2e-45 153.9 0.6 4.6e-45 152.7 0.6 1.6 1 1 0 1 1 1 1 Thg1 C terminal domain Ferric_reduct PF01794.19 ETS63617.1 - 3.3e-21 75.7 15.9 3.3e-21 75.7 15.9 2.4 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ETS63617.1 - 4.4e-13 49.3 0.0 1e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ETS63617.1 - 1.1e-11 45.1 0.0 1.5e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NmrA PF05368.13 ETS63618.1 - 1.2e-13 51.2 0.0 1.6e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ETS63618.1 - 2.2e-13 50.5 0.0 3.5e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETS63618.1 - 9.1e-12 44.9 0.1 7.6e-11 41.9 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETS63618.1 - 4.3e-10 39.1 0.0 1.3e-09 37.5 0.0 1.6 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETS63618.1 - 2.9e-09 36.5 0.0 4.7e-08 32.5 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ETS63618.1 - 3.4e-06 26.4 0.1 0.12 11.5 0.0 3.1 1 1 1 3 3 3 2 Male sterility protein GDP_Man_Dehyd PF16363.5 ETS63618.1 - 1.1e-05 25.0 0.1 2.9e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 ETS63618.1 - 0.0002 20.9 0.0 0.00056 19.4 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS63618.1 - 0.00029 20.5 0.0 0.0032 17.1 0.0 2.2 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS63618.1 - 0.016 15.2 0.0 0.12 12.3 0.0 2.1 2 0 0 2 2 2 0 KR domain Polysacc_synt_2 PF02719.15 ETS63618.1 - 0.019 14.1 0.0 0.03 13.4 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 ETS63618.1 - 0.074 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus HhH-GPD PF00730.25 ETS63619.1 - 7.1e-12 45.7 0.0 1.3e-11 44.9 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein eIF3_N PF09440.10 ETS63620.1 - 8.9e-45 152.4 0.4 2.2e-44 151.1 0.4 1.7 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 ETS63620.1 - 1.3e-10 41.7 0.1 5.2e-10 39.8 0.1 1.9 2 0 0 2 2 2 1 PCI domain MFS_1 PF07690.16 ETS63621.1 - 1.8e-10 40.3 13.6 1.8e-10 40.3 13.6 2.9 2 2 0 2 2 2 1 Major Facilitator Superfamily CPP1-like PF11833.8 ETS63621.1 - 0.0087 15.7 5.3 0.011 15.5 4.1 1.8 1 1 0 1 1 1 1 Protein CHAPERONE-LIKE PROTEIN OF POR1-like LtrA PF06772.11 ETS63622.1 - 8.8e-31 107.4 25.8 1.2e-30 107.0 25.8 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) DUF1211 PF06736.11 ETS63622.1 - 0.3 11.6 4.5 0.83 10.1 2.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1211) Zn_clus PF00172.18 ETS63623.1 - 2.3e-06 27.6 13.6 4.9e-06 26.5 13.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS63623.1 - 0.015 14.3 0.0 0.032 13.3 0.0 1.5 1 0 0 1 1 1 0 Fungal specific transcription factor domain RAP1 PF07218.11 ETS63623.1 - 1.8 6.8 7.8 4.1 5.5 7.8 1.5 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) UCH PF00443.29 ETS63624.1 - 8.6e-52 176.2 0.0 1.1e-51 175.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS63624.1 - 1.6e-28 100.3 0.1 5.3e-21 75.5 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ETS63624.1 - 2.1 7.7 4.5 1.2 8.6 1.2 2.1 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Raffinose_syn PF05691.12 ETS63625.1 - 5.6e-23 80.7 0.0 1.4e-21 76.1 0.0 2.3 2 0 0 2 2 2 2 Raffinose synthase or seed imbibition protein Sip1 MFS_1 PF07690.16 ETS63626.1 - 6.8e-32 110.8 20.2 6.8e-32 110.8 20.2 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ETS63626.1 - 2.6e-07 29.9 2.3 5.5e-07 28.8 2.2 1.4 1 1 0 1 1 1 1 MFS_1 like family OATP PF03137.20 ETS63626.1 - 0.025 12.9 0.2 0.025 12.9 0.2 3.0 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Vpu PF00558.19 ETS63626.1 - 0.25 11.1 1.0 0.52 10.1 0.1 1.9 2 0 0 2 2 2 0 Vpu protein EXS PF03124.14 ETS63626.1 - 2.6 7.3 11.9 0.14 11.5 4.4 2.5 2 1 0 2 2 2 0 EXS family DASH_Dad4 PF08650.10 ETS63627.1 - 4.1e-25 87.5 3.2 4.6e-25 87.4 3.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 Ins134_P3_kin PF05770.11 ETS63627.1 - 0.035 13.6 0.1 0.038 13.5 0.1 1.0 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain E1-E2_ATPase PF00122.20 ETS63628.1 - 1.7e-21 76.6 0.0 4.3e-21 75.2 0.0 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ETS63628.1 - 1.2e-15 58.4 0.0 2.5e-08 34.5 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS63628.1 - 0.0062 16.6 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETS63628.1 - 0.024 14.4 0.0 0.086 12.6 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ETS63628.1 - 0.085 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Bac_rhodopsin PF01036.18 ETS63629.1 - 2.4e-44 151.6 15.4 3.2e-44 151.2 15.4 1.0 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein ResIII PF04851.15 ETS63629.1 - 0.28 11.2 0.6 0.45 10.5 0.6 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Arteri_Gl PF00951.18 ETS63629.1 - 1.5 8.6 7.5 0.1 12.4 0.6 2.0 2 0 0 2 2 2 0 Arterivirus GL envelope glycoprotein UQ_con PF00179.26 ETS63630.1 - 1.6e-40 138.0 0.0 1.8e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETS63630.1 - 0.0009 19.5 0.0 0.001 19.3 0.0 1.2 1 0 0 1 1 1 1 RWD domain UFC1 PF08694.11 ETS63630.1 - 0.006 16.2 0.0 0.0087 15.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-fold modifier-conjugating enzyme 1 Prok-E2_B PF14461.6 ETS63630.1 - 0.059 13.1 0.0 0.084 12.6 0.0 1.3 1 1 0 1 1 1 0 Prokaryotic E2 family B PLDc PF00614.22 ETS63631.1 - 5.2e-15 54.9 0.2 2.7e-06 27.3 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ETS63631.1 - 6.6e-13 48.7 0.0 2.1e-07 30.9 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 ETS63631.1 - 3.4e-10 39.9 0.0 1e-09 38.3 0.0 1.8 1 0 0 1 1 1 1 PX domain PH PF00169.29 ETS63631.1 - 1.3 9.6 3.4 12 6.5 0.8 3.6 3 1 0 3 3 3 0 PH domain Rrp15p PF07890.12 ETS63632.1 - 3.3e-32 111.6 6.3 3.3e-32 111.6 6.3 2.6 1 1 1 2 2 2 1 Rrp15p ATP-grasp_2 PF08442.10 ETS63633.1 - 2.3e-71 239.5 0.9 3.3e-71 239.0 0.2 1.6 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 ETS63633.1 - 5.5e-22 78.2 1.2 1.2e-21 77.1 0.7 1.8 2 0 0 2 2 2 1 CoA-ligase ATP-grasp_5 PF13549.6 ETS63633.1 - 1.9e-11 43.9 0.6 3.8e-11 42.9 0.1 1.7 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ETS63633.1 - 0.00015 21.6 0.9 0.00032 20.5 0.2 2.0 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp PF02222.22 ETS63633.1 - 0.015 14.9 0.0 0.044 13.3 0.0 1.9 1 0 0 1 1 1 0 ATP-grasp domain PASTA PF03793.19 ETS63633.1 - 0.19 11.6 0.3 1 9.3 0.1 2.3 2 0 0 2 2 2 0 PASTA domain Ceramidase_alk PF04734.13 ETS63634.1 - 6.6e-178 592.5 0.0 9.2e-177 588.7 0.0 2.0 1 1 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 ETS63634.1 - 1.1e-42 145.8 1.0 1.7e-33 115.9 1.5 2.5 1 1 1 2 2 2 2 Neutral/alkaline non-lysosomal ceramidase, C-terminal MCM PF00493.23 ETS63635.1 - 4e-103 343.3 0.8 6e-103 342.8 0.8 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETS63635.1 - 7.8e-41 138.9 0.8 1.5e-40 138.0 0.8 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 ETS63635.1 - 5.8e-30 103.7 0.7 1.4e-29 102.5 0.7 1.7 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 ETS63635.1 - 9.9e-26 90.0 1.5 2e-25 89.0 0.3 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ETS63635.1 - 2.8e-20 72.8 0.1 1.1e-19 71.0 0.1 2.1 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ETS63635.1 - 1.5e-07 31.0 0.0 7.4e-07 28.8 0.0 2.0 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETS63635.1 - 0.0022 17.8 0.0 0.0061 16.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETS63635.1 - 0.0025 17.5 0.0 0.0053 16.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Succ_DH_flav_C PF02910.20 ETS63635.1 - 0.017 15.1 0.2 0.049 13.6 0.0 1.8 2 0 0 2 2 2 0 Fumarate reductase flavoprotein C-term AAA_5 PF07728.14 ETS63635.1 - 0.038 14.0 0.0 0.14 12.1 0.0 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Nop PF01798.18 ETS63637.1 - 1.8e-70 237.0 0.0 2.6e-70 236.5 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 ETS63637.1 - 8e-39 133.3 4.4 8e-39 133.3 4.4 2.0 2 0 0 2 2 2 1 Prp31 C terminal domain DUF4637 PF15470.6 ETS63637.1 - 0.064 13.0 0.3 0.064 13.0 0.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4637) AMP-binding PF00501.28 ETS63638.1 - 1.4e-82 277.5 0.0 2.5e-82 276.7 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS63638.1 - 3.6e-19 69.5 0.1 1.4e-18 67.6 0.1 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ADH_zinc_N PF00107.26 ETS63638.1 - 1.6e-16 60.4 1.0 1.6e-16 60.4 1.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ACAS_N PF16177.5 ETS63638.1 - 3.2e-14 52.6 0.1 9.1e-14 51.1 0.1 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus ADH_zinc_N_2 PF13602.6 ETS63638.1 - 2.6e-08 35.0 1.2 7.2e-08 33.6 0.2 2.4 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS63638.1 - 0.0061 16.4 0.7 0.053 13.4 0.0 3.0 3 1 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ACP_syn_III_C PF08541.10 ETS63638.1 - 0.054 13.7 0.1 0.22 11.7 0.1 2.0 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal MOSC PF03473.17 ETS63639.1 - 2.4e-22 79.3 0.0 3.8e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 ETS63639.1 - 2.3e-19 69.4 0.0 5.5e-19 68.2 0.0 1.6 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain CorA PF01544.18 ETS63640.1 - 1.8e-44 152.2 0.2 2.7e-44 151.7 0.2 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 ETS63640.1 - 0.11 12.6 0.9 0.24 11.4 0.9 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus SUR7 PF06687.12 ETS63641.1 - 9.9e-25 87.4 3.2 1.8e-24 86.6 3.2 1.4 1 0 0 1 1 1 1 SUR7/PalI family Spo7 PF03907.13 ETS63642.1 - 1.8 8.0 7.1 0.2 11.1 2.4 1.8 2 0 0 2 2 2 0 Spo7-like protein Ferritin_2 PF13668.6 ETS63643.1 - 4.7e-18 65.7 0.1 6.8e-18 65.2 0.1 1.3 1 0 0 1 1 1 1 Ferritin-like domain PP_M1 PF03012.14 ETS63644.1 - 0.2 11.2 1.4 14 5.1 0.0 2.3 2 0 0 2 2 2 0 Phosphoprotein HTH_psq PF05225.16 ETS63645.1 - 0.017 14.9 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain Fib_alpha PF08702.10 ETS63645.1 - 0.026 14.7 1.5 0.039 14.1 1.5 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TMCO5 PF14992.6 ETS63645.1 - 0.027 14.0 0.1 0.028 14.0 0.1 1.1 1 0 0 1 1 1 0 TMCO5 family MitMem_reg PF13012.6 ETS63645.1 - 0.028 14.8 0.2 0.037 14.5 0.2 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function Jnk-SapK_ap_N PF09744.9 ETS63645.1 - 0.032 14.4 2.1 0.053 13.8 2.1 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 NPA PF16469.5 ETS63645.1 - 0.067 13.8 0.3 0.1 13.2 0.3 1.4 1 0 0 1 1 1 0 Nematode polyprotein allergen ABA-1 GIT_CC PF16559.5 ETS63645.1 - 0.069 13.0 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Bacillus_HBL PF05791.11 ETS63645.1 - 0.13 12.0 2.1 0.2 11.5 2.1 1.2 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Trimer_CC PF08954.11 ETS63645.1 - 0.31 10.6 2.8 0.28 10.8 0.7 2.1 2 0 0 2 2 2 0 Trimerisation motif Aldolase_II PF00596.21 ETS63646.1 - 1.4e-43 149.1 0.0 1.7e-43 148.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain SET PF00856.28 ETS63647.1 - 2.1e-16 60.8 5.1 2.2e-16 60.7 0.0 3.4 2 2 0 2 2 2 1 SET domain AWS PF17907.1 ETS63647.1 - 4e-12 45.9 4.2 4e-12 45.9 4.2 1.7 2 0 0 2 2 2 1 AWS domain DUF3072 PF11272.8 ETS63647.1 - 0.075 12.9 1.0 0.28 11.1 1.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) Zn_clus PF00172.18 ETS63648.1 - 1.2e-06 28.5 10.3 2e-06 27.8 10.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS63648.1 - 0.00044 19.4 0.0 0.0049 15.9 0.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Ribosomal_L7Ae PF01248.26 ETS63650.1 - 7.9e-21 73.6 0.7 1.5e-20 72.7 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HTH_Tnp_Tc5 PF03221.16 ETS63651.1 - 4.5e-13 49.0 0.0 9.6e-13 48.0 0.0 1.6 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain CENP-B_N PF04218.13 ETS63651.1 - 0.00013 21.5 0.1 0.00031 20.3 0.1 1.6 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain HTH_Tnp_4 PF13613.6 ETS63651.1 - 0.029 14.1 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease MAPEG PF01124.18 ETS63652.1 - 1.7e-14 53.9 5.2 2.1e-14 53.5 5.2 1.1 1 0 0 1 1 1 1 MAPEG family Iso_dh PF00180.20 ETS63653.1 - 3.2e-85 286.3 0.0 3.8e-85 286.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF166 PF02593.14 ETS63653.1 - 0.19 11.2 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function Ribosomal_L13 PF00572.18 ETS63654.1 - 5.8e-53 178.4 0.4 9.1e-53 177.8 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L13 DUF1115 PF06544.12 ETS63656.1 - 2.6e-06 27.6 0.0 4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) Sigma70_r4_2 PF08281.12 ETS63656.1 - 0.16 11.6 0.0 0.37 10.5 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Peptidase_M43 PF05572.13 ETS63657.1 - 4.6e-16 59.1 0.1 8.1e-16 58.3 0.1 1.4 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 ETS63657.1 - 0.0003 21.0 0.4 0.00063 20.0 0.1 1.7 1 1 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 ETS63657.1 - 0.00074 19.4 0.1 0.0024 17.7 0.0 1.3 1 1 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 ETS63657.1 - 0.0015 19.0 1.9 0.0046 17.5 0.2 2.5 1 1 1 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 ETS63657.1 - 0.028 13.4 0.1 0.052 12.5 0.1 1.4 1 0 0 1 1 1 0 Peptidase M66 DUF4953 PF16313.5 ETS63657.1 - 0.033 13.4 0.4 0.086 12.0 0.0 1.7 2 0 0 2 2 2 0 Met-zincin Reprolysin_4 PF13583.6 ETS63657.1 - 0.06 13.0 1.2 0.092 12.4 0.1 1.8 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.11 ETS63657.1 - 0.13 12.2 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M54 Astacin PF01400.24 ETS63657.1 - 0.36 10.4 1.4 2.6 7.6 0.2 2.3 2 0 0 2 2 2 0 Astacin (Peptidase family M12A) ADH_N PF08240.12 ETS63658.1 - 1.4e-27 95.7 0.2 3.6e-27 94.4 0.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS63658.1 - 1.2e-19 70.5 2.5 7.7e-19 68.0 2.5 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ETS63658.1 - 2.8e-08 33.5 0.1 0.0056 16.2 0.0 3.1 3 0 0 3 3 3 2 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ETS63658.1 - 0.001 20.1 0.1 0.0062 17.6 0.1 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ETS63658.1 - 0.035 13.4 0.1 0.059 12.7 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain PrmA PF06325.13 ETS63658.1 - 0.062 12.7 0.7 0.097 12.0 0.7 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) AdoHcyase_NAD PF00670.21 ETS63658.1 - 0.069 13.2 0.4 4.5 7.3 0.2 2.4 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Aldo_ket_red PF00248.21 ETS63659.1 - 3.1e-46 157.9 0.1 7.7e-45 153.3 0.1 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family Peptidase_C48 PF02902.19 ETS63659.1 - 1.5e-27 96.9 0.0 5e-19 69.0 0.0 2.7 2 1 0 2 2 2 2 Ulp1 protease family, C-terminal catalytic domain FTO_CTD PF12934.7 ETS63659.1 - 0.11 12.3 0.6 0.27 11.0 0.6 1.6 1 0 0 1 1 1 0 FTO C-terminal domain Methyltransf_28 PF02636.17 ETS63661.1 - 2.2e-38 132.4 0.0 4.2e-38 131.5 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 ETS63661.1 - 0.0017 17.4 0.0 0.0033 16.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PRMT5 PF05185.16 ETS63661.1 - 0.002 18.0 0.0 0.0047 16.8 0.0 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.12 ETS63661.1 - 0.0081 16.9 0.0 0.027 15.2 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63661.1 - 0.026 15.2 0.2 0.14 12.8 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain HECT PF00632.25 ETS63662.1 - 1.1e-90 304.2 0.0 1.8e-90 303.6 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) GST_C_3 PF14497.6 ETS63663.1 - 2.1e-20 72.8 0.1 3.9e-20 71.9 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETS63663.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ADH_N PF08240.12 ETS63664.1 - 6.2e-27 93.6 1.0 1e-26 92.9 1.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS63664.1 - 5.6e-12 45.8 0.0 9e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ETS63664.1 - 2.7e-05 23.8 2.4 0.0068 15.9 2.4 2.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ETS63664.1 - 0.0051 17.9 0.0 0.0094 17.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase HA2 PF04408.23 ETS63665.1 - 7.2e-15 55.2 0.1 2.1e-14 53.7 0.1 1.9 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETS63665.1 - 6.7e-11 42.4 0.1 7.1e-10 39.1 0.0 2.5 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ETS63665.1 - 2.8e-10 40.5 0.0 6.4e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS63665.1 - 4.9e-05 23.2 0.2 0.00028 20.7 0.2 2.2 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETS63665.1 - 0.00086 19.6 0.0 0.004 17.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETS63665.1 - 0.0028 18.0 0.1 0.0065 16.8 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS63665.1 - 0.018 14.8 0.5 0.059 13.1 0.2 2.1 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 ETS63665.1 - 0.021 14.3 0.1 0.094 12.2 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein T2SSE PF00437.20 ETS63665.1 - 0.035 13.2 0.0 0.084 11.9 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 ETS63665.1 - 0.069 13.5 0.0 0.31 11.4 0.0 2.2 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ETS63665.1 - 0.07 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family ATPase PF06745.13 ETS63665.1 - 0.16 11.3 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_29 PF13555.6 ETS63665.1 - 0.3 10.9 1.4 2.5 7.9 0.7 2.3 1 1 1 2 2 2 0 P-loop containing region of AAA domain Pkinase PF00069.25 ETS63666.1 - 3.3e-68 229.9 0.0 4.2e-68 229.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63666.1 - 1.7e-29 102.9 0.0 2.5e-29 102.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETS63666.1 - 0.034 14.0 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETS63666.1 - 0.052 12.5 0.0 0.083 11.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Tyosinase_C PF18132.1 ETS63667.1 - 0.0081 16.8 0.0 0.037 14.7 0.0 2.0 2 1 0 2 2 2 1 Tyosinase C-terminal domain NMT1 PF09084.11 ETS63667.1 - 0.009 16.0 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 NMT1/THI5 like GMC_oxred_N PF00732.19 ETS63668.1 - 4.4e-50 170.7 0.0 7e-50 170.1 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS63668.1 - 5.5e-34 117.8 0.0 9.3e-34 117.0 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 ETS63668.1 - 3.7e-05 23.1 0.0 0.0017 17.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS63668.1 - 0.0001 21.6 0.4 0.048 12.7 0.4 2.3 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ETS63668.1 - 0.0006 20.0 0.2 0.0029 17.8 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ETS63668.1 - 0.00081 18.5 0.1 0.0013 17.9 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein DAO PF01266.24 ETS63668.1 - 0.0013 18.4 1.0 0.081 12.5 0.8 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ETS63668.1 - 0.17 11.9 0.1 0.44 10.5 0.1 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding Thi4 PF01946.17 ETS63668.1 - 0.17 11.1 0.1 0.36 10.0 0.1 1.4 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.18 ETS63668.1 - 0.18 12.0 0.2 0.4 10.9 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain Trp_halogenase PF04820.14 ETS63668.1 - 0.25 10.1 0.1 0.35 9.7 0.1 1.1 1 0 0 1 1 1 0 Tryptophan halogenase Calcipressin PF04847.12 ETS63669.1 - 1.3e-26 93.5 0.0 2.7e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 Calcipressin Voldacs PF03517.13 ETS63669.1 - 6.3e-26 91.1 0.4 2.5e-24 86.0 0.0 2.9 2 1 0 2 2 2 1 Regulator of volume decrease after cellular swelling RRM_1 PF00076.22 ETS63669.1 - 0.17 11.7 0.0 0.41 10.5 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L36e PF01158.18 ETS63670.1 - 9.3e-39 131.6 6.9 9.4e-39 131.6 5.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L36e Lactamase_B PF00753.27 ETS63671.1 - 4.7e-20 72.4 3.4 6.5e-20 72.0 3.4 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETS63671.1 - 8.3e-06 25.5 0.5 1.3e-05 24.8 0.5 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF3606 PF12244.8 ETS63671.1 - 0.026 14.4 0.0 0.049 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) Glyco_transf_20 PF00982.21 ETS63672.1 - 1.5e-186 620.7 0.0 2.8e-138 461.6 0.0 2.0 2 0 0 2 2 2 2 Glycosyltransferase family 20 Glycos_transf_1 PF00534.20 ETS63672.1 - 0.014 14.9 0.1 2.5 7.6 0.0 2.5 2 1 0 2 2 2 0 Glycosyl transferases group 1 GCV_T PF01571.21 ETS63673.1 - 6.8e-85 284.5 0.0 1e-84 283.9 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 ETS63673.1 - 5.6e-23 80.7 0.1 1.3e-22 79.4 0.1 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Abhydrolase_1 PF00561.20 ETS63675.1 - 1.6e-34 119.7 0.2 2.2e-34 119.2 0.2 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS63675.1 - 1.4e-10 40.9 0.0 1.4e-09 37.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS63675.1 - 5e-10 40.4 1.8 9.6e-10 39.4 1.8 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 ETS63675.1 - 0.16 10.7 0.0 0.26 10.0 0.0 1.3 1 0 0 1 1 1 0 Ndr family NUFIP1 PF10453.9 ETS63676.1 - 3.6e-13 49.1 4.1 9.9e-13 47.7 4.1 1.8 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH_4 PF18044.1 ETS63676.1 - 6.5e-06 25.8 2.9 1.1e-05 25.1 2.9 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 ETS63676.1 - 9.2e-05 22.3 2.0 0.00022 21.1 2.0 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS63676.1 - 0.00026 20.9 3.3 0.00054 19.9 3.3 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 ETS63676.1 - 0.0015 19.2 0.1 0.0015 19.2 0.1 2.3 3 0 0 3 3 3 1 Torus domain CSRNP_N PF16019.5 ETS63676.1 - 8.8 6.2 9.3 0.41 10.5 2.7 2.1 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus SNF2_N PF00176.23 ETS63677.1 - 4.9e-57 193.2 0.0 8.3e-57 192.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4 PF00097.25 ETS63677.1 - 2.9e-07 30.3 8.4 6.4e-07 29.1 8.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS63677.1 - 9.4e-06 25.4 5.9 2.2e-05 24.2 5.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS63677.1 - 1.8e-05 25.0 10.3 4e-05 23.9 10.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ETS63677.1 - 9.8e-05 22.3 9.0 0.00022 21.2 9.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETS63677.1 - 0.00012 21.9 6.5 0.00027 20.8 6.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS63677.1 - 0.00096 18.9 9.2 0.0058 16.4 9.2 2.3 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Helicase_C PF00271.31 ETS63677.1 - 0.002 18.5 0.0 0.0051 17.2 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_5 PF17121.5 ETS63677.1 - 0.091 12.7 0.9 0.26 11.2 0.9 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETS63677.1 - 0.45 10.7 8.5 1 9.6 8.5 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ETS63677.1 - 1.2 9.0 6.8 2.8 7.8 6.8 1.7 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 ETS63677.1 - 1.5 8.7 7.5 4 7.4 7.5 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ETS63677.1 - 5.4 7.4 6.7 14 6.0 6.7 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ETS63677.1 - 6.6 6.6 11.5 2.1 8.2 6.2 2.7 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Ribosomal_L4 PF00573.22 ETS63680.1 - 1.2e-70 237.1 0.0 1.8e-70 236.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Sec16_N PF12935.7 ETS63681.1 - 0.068 13.3 0.2 0.078 13.1 0.2 1.1 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus Ribosomal_S9 PF00380.19 ETS63682.1 - 9.3e-31 106.9 0.2 1.1e-30 106.7 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF630 PF04783.12 ETS63682.1 - 1.4 9.2 4.2 16 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF630) SPA PF08616.10 ETS63683.1 - 9.8e-07 28.7 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Stabilization of polarity axis Ribosomal_L35p PF01632.19 ETS63685.1 - 2.9e-07 30.9 9.1 4.5e-07 30.3 5.4 2.6 2 1 0 2 2 2 1 Ribosomal protein L35 HCNGP PF07818.13 ETS63686.1 - 8.6e-18 64.8 0.0 1.9e-17 63.7 0.0 1.5 1 0 0 1 1 1 1 HCNGP-like protein PEX11 PF05648.14 ETS63687.1 - 2.9e-17 62.9 0.0 1e-15 57.8 0.0 2.1 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PHD PF00628.29 ETS63690.1 - 3.4e-11 42.9 8.4 7.9e-11 41.7 8.4 1.6 1 0 0 1 1 1 1 PHD-finger RAP1 PF07218.11 ETS63690.1 - 6.9 4.8 6.7 11 4.1 6.7 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4629 PF15442.6 ETS63690.1 - 9.9 6.4 15.3 0.33 11.2 2.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4629) TrbC PF04956.13 ETS63692.1 - 0.019 15.2 0.1 0.021 15.0 0.1 1.2 1 0 0 1 1 1 0 TrbC/VIRB2 family Cutinase PF01083.22 ETS63693.1 - 6.4e-20 71.8 1.3 7.4e-20 71.6 1.3 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 ETS63693.1 - 7.2e-05 22.4 0.1 0.0001 22.0 0.1 1.2 1 0 0 1 1 1 1 PE-PPE domain Glyco_hydro_3_C PF01915.22 ETS63695.1 - 2.6e-53 181.0 0.0 5.1e-53 180.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ETS63695.1 - 6.5e-39 134.2 0.0 1.1e-38 133.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ETS63695.1 - 2e-14 53.4 0.1 3.8e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PPP4R2 PF09184.11 ETS63696.1 - 2.5e-11 43.7 0.8 2.5e-11 43.7 0.8 2.4 2 1 0 2 2 2 1 PPP4R2 ABC_membrane PF00664.23 ETS63698.1 - 2.3e-50 171.8 23.1 4.3e-33 115.1 8.0 3.6 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS63698.1 - 6e-49 166.1 0.0 4.9e-27 95.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ETS63698.1 - 9.5e-12 44.8 0.2 0.019 14.4 0.0 4.4 3 1 1 4 4 4 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETS63698.1 - 8.3e-08 33.0 3.1 5.4e-05 23.8 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 ETS63698.1 - 1.1e-07 31.5 0.5 0.00093 18.9 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA PF00004.29 ETS63698.1 - 1.5e-06 28.7 0.1 0.077 13.4 0.0 3.7 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ETS63698.1 - 4.5e-06 26.7 1.2 0.18 11.6 0.2 3.9 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ETS63698.1 - 0.00011 22.5 0.1 0.42 10.9 0.1 3.1 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 ETS63698.1 - 0.00016 22.1 1.3 0.46 10.8 0.0 3.2 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ETS63698.1 - 0.00032 20.6 0.2 0.022 14.6 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase T2SSE PF00437.20 ETS63698.1 - 0.00052 19.2 0.1 0.088 11.9 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_25 PF13481.6 ETS63698.1 - 0.00078 19.1 0.2 2.2 7.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_24 PF13479.6 ETS63698.1 - 0.001 18.8 3.0 0.013 15.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.23 ETS63698.1 - 0.0011 19.0 0.4 1.8 8.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_15 PF13175.6 ETS63698.1 - 0.0023 17.7 0.0 0.46 10.1 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 ETS63698.1 - 0.0031 17.6 2.4 0.039 14.0 0.0 3.2 4 0 0 4 4 3 1 Dynamin family IstB_IS21 PF01695.17 ETS63698.1 - 0.01 15.6 0.0 3.7 7.3 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 ETS63698.1 - 0.011 15.3 0.2 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 ETS63698.1 - 0.011 15.0 0.0 1.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.18 ETS63698.1 - 0.024 14.0 1.2 0.37 10.1 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF87 PF01935.17 ETS63698.1 - 0.032 14.3 2.8 3 7.9 0.1 2.7 2 0 0 2 2 2 0 Helicase HerA, central domain NB-ARC PF00931.22 ETS63698.1 - 0.048 12.8 0.3 5.2 6.2 0.1 2.9 3 0 0 3 3 3 0 NB-ARC domain AAA_18 PF13238.6 ETS63698.1 - 0.072 13.6 0.2 6.2 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ETS63698.1 - 0.18 12.0 0.4 22 5.3 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 ETS63698.1 - 0.19 11.3 1.0 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ETS63698.1 - 0.19 11.8 4.0 3.1 7.9 0.1 3.2 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 ETS63698.1 - 0.21 12.0 0.1 14 6.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase cobW PF02492.19 ETS63698.1 - 0.34 10.5 1.2 2.5 7.6 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ETS63698.1 - 0.39 10.6 2.7 9.6 6.1 0.1 3.0 3 0 0 3 3 3 0 NACHT domain UQ_con PF00179.26 ETS63699.1 - 7.4e-16 58.1 0.0 1e-15 57.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETS63699.1 - 0.04 13.6 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B PigN PF04987.14 ETS63700.1 - 2.4e-109 366.3 14.0 3.3e-109 365.8 14.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 ETS63700.1 - 3.7e-05 23.5 1.0 0.0022 17.6 0.2 2.5 3 0 0 3 3 3 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ETS63700.1 - 0.0006 19.3 0.0 0.00099 18.6 0.0 1.2 1 0 0 1 1 1 1 Sulfatase TPR_MalT PF17874.1 ETS63700.1 - 0.2 11.0 1.9 10 5.4 0.6 2.3 1 1 1 2 2 2 0 MalT-like TPR region Chromo PF00385.24 ETS63701.1 - 8.9e-05 22.3 0.1 0.00021 21.1 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PI3Ka PF00613.20 ETS63702.1 - 1.5e-52 177.7 0.0 2.3e-52 177.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETS63702.1 - 1.1e-46 159.7 0.0 9.8e-44 150.0 0.0 2.5 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ETS63702.1 - 2.4e-37 127.9 0.0 4.3e-37 127.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 C2 PF00168.30 ETS63702.1 - 0.0089 16.3 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain DUF4135 PF13575.6 ETS63702.1 - 0.058 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) RecC_C PF17946.1 ETS63702.1 - 0.065 13.0 0.2 6.5 6.5 0.1 2.5 2 0 0 2 2 2 0 RecC C-terminal domain Mito_carr PF00153.27 ETS63703.1 - 2.9e-38 129.7 7.7 3.2e-17 62.2 0.2 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein CTK3 PF12243.8 ETS63703.1 - 1.6e-18 66.8 0.0 3.2e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 ETS63703.1 - 4.6e-17 61.9 3.4 8.8e-17 61.0 3.4 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus YjeJ PF15922.5 ETS63703.1 - 0.06 12.6 0.0 0.096 11.9 0.0 1.2 1 0 0 1 1 1 0 YjeJ-like Fungal_trans_2 PF11951.8 ETS63704.1 - 3.4e-12 45.9 3.6 2.1e-06 26.8 0.0 2.4 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63704.1 - 0.00064 19.8 10.2 0.0011 19.0 10.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Cwf_Cwc_15 PF04889.12 ETS63704.1 - 2.6 7.7 9.8 6.3 6.5 9.5 1.8 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TPR_1 PF00515.28 ETS63705.1 - 5.3e-22 76.7 12.1 0.0038 17.0 0.1 10.2 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETS63705.1 - 4e-20 70.2 27.8 0.0088 16.1 0.2 13.9 17 0 0 17 17 15 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETS63705.1 - 2.2e-15 55.5 11.8 0.35 11.2 0.0 12.2 14 0 0 14 14 13 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS63705.1 - 1.5e-14 53.2 11.7 0.053 13.9 0.0 11.8 12 1 1 13 13 13 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETS63705.1 - 5.8e-14 52.5 66.2 1.2e-05 25.8 2.1 14.4 11 4 7 18 18 17 5 Tetratricopeptide repeat TPR_19 PF14559.6 ETS63705.1 - 3.1e-12 46.8 41.4 0.00066 20.1 0.0 11.3 9 3 4 14 14 12 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETS63705.1 - 2.6e-11 43.7 44.8 1.2e-07 31.9 0.0 11.4 12 2 0 12 12 12 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETS63705.1 - 4.4e-11 42.0 6.3 0.19 11.8 0.1 7.7 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETS63705.1 - 6.1e-11 42.2 82.4 0.0003 21.4 0.2 18.4 17 6 4 21 21 18 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETS63705.1 - 1.6e-07 30.9 11.6 0.025 14.3 0.1 7.0 6 0 0 6 6 6 2 TPR repeat ANAPC3 PF12895.7 ETS63705.1 - 4.2e-06 26.9 10.8 0.25 11.6 0.0 6.7 6 1 1 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ETS63705.1 - 1.3e-05 24.9 2.6 1.9 8.4 0.0 5.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETS63705.1 - 2.4e-05 24.6 26.0 0.075 13.7 0.0 11.3 12 0 0 12 12 11 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETS63705.1 - 2.9e-05 24.1 30.0 0.51 10.5 0.6 9.6 7 3 3 10 10 9 2 Tetratricopeptide repeat TPR_22 PF18833.1 ETS63705.1 - 0.0058 16.7 0.0 0.041 14.0 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.10 ETS63705.1 - 0.072 12.1 0.2 0.32 9.9 0.0 2.0 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) NAD_binding_7 PF13241.6 ETS63706.1 - 1.4e-27 96.1 0.0 2.5e-27 95.3 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 ETS63706.1 - 3.2e-26 90.7 0.4 5.3e-26 90.1 0.4 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 ETS63706.1 - 3.8e-11 42.2 0.4 8.5e-11 41.1 0.4 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Cnd3 PF12719.7 ETS63707.1 - 4.5e-82 275.6 4.7 1.4e-81 273.9 0.2 2.6 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 ETS63707.1 - 5.1e-12 46.0 7.3 1e-06 29.0 0.5 4.3 2 2 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ETS63707.1 - 7.2e-09 36.0 7.2 0.088 13.3 0.1 5.9 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 ETS63707.1 - 5.7e-08 32.4 11.1 1.1 9.7 0.0 6.8 5 0 0 5 5 5 4 HEAT repeat Cnd1 PF12717.7 ETS63707.1 - 8.3e-06 25.9 3.3 0.026 14.5 0.4 3.7 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 DUF4611 PF15387.6 ETS63707.1 - 0.0027 17.9 18.0 6.2 7.1 0.5 4.7 4 0 0 4 4 4 3 Domain of unknown function (DUF4611) RTP1_C1 PF10363.9 ETS63707.1 - 0.066 13.4 5.0 9.9 6.4 0.1 4.4 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 RNase_PH PF01138.21 ETS63708.1 - 3.2e-25 89.2 0.0 6.1e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Pil1 PF13805.6 ETS63709.1 - 3.8e-69 233.1 2.1 7.2e-69 232.2 2.1 1.4 1 0 0 1 1 1 1 Eisosome component PIL1 PDT PF00800.18 ETS63709.1 - 8.6e-65 218.0 1.1 2.5e-64 216.5 0.0 2.3 3 0 0 3 3 3 1 Prephenate dehydratase DUF2408 PF10303.9 ETS63709.1 - 0.19 12.3 0.9 0.43 11.1 0.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) ARGLU PF15346.6 ETS63709.1 - 1 9.2 17.4 0.32 10.8 8.7 2.3 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 zf-CCHC PF00098.23 ETS63710.1 - 0.0072 16.4 34.0 0.0087 16.1 3.0 4.9 4 0 0 4 4 4 4 Zinc knuckle Zn_Tnp_IS91 PF14319.6 ETS63710.1 - 8.1 6.6 11.1 20 5.3 3.9 2.5 2 0 0 2 2 2 0 Transposase zinc-binding domain Arrestin_N PF00339.29 ETS63711.1 - 0.00025 21.1 0.0 0.00057 20.0 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF4203 PF13886.6 ETS63712.1 - 5e-06 26.3 24.0 5e-06 26.3 24.0 3.0 2 1 0 3 3 3 1 Domain of unknown function (DUF4203) Sigma70_ECF PF07638.11 ETS63712.1 - 0.071 13.0 0.2 0.13 12.1 0.2 1.3 1 0 0 1 1 1 0 ECF sigma factor Zn_clus PF00172.18 ETS63714.1 - 8.5e-08 32.2 6.0 1.3e-07 31.6 6.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Formyl_trans_N PF00551.19 ETS63715.1 - 2.8e-30 105.4 0.0 5e-18 65.5 0.1 2.8 2 0 0 2 2 2 2 Formyl transferase Histone PF00125.24 ETS63717.1 - 4.3e-17 62.7 1.4 1.2e-16 61.2 0.0 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ETS63717.1 - 2.9e-14 52.5 0.1 2.5e-12 46.3 0.2 2.4 2 0 0 2 2 2 2 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ETS63717.1 - 0.068 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone NFACT-R_1 PF05670.13 ETS63718.1 - 3.2e-39 133.9 0.0 5.8e-39 133.1 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain FYDLN_acid PF09538.10 ETS63718.1 - 1.6 9.4 10.7 0.47 11.2 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Pkinase PF00069.25 ETS63719.1 - 1.1e-64 218.4 0.0 3.1e-64 216.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63719.1 - 7.5e-40 136.8 0.0 9.7e-40 136.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS63719.1 - 2.6e-07 30.3 0.0 3.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 ETS63719.1 - 0.049 13.3 0.0 0.19 11.3 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ETS63719.1 - 0.092 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MutS_V PF00488.21 ETS63720.1 - 2.3e-27 96.2 0.0 4.7e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETS63720.1 - 1.3e-13 51.6 0.6 2.6e-13 50.6 0.6 1.5 1 0 0 1 1 1 1 MutS domain III CCDC154 PF15450.6 ETS63720.1 - 0.025 13.1 0.3 0.043 12.4 0.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 154 MutS_IV PF05190.18 ETS63720.1 - 0.11 12.9 0.0 0.75 10.2 0.0 2.3 1 1 0 1 1 1 0 MutS family domain IV IstB_IS21 PF01695.17 ETS63720.1 - 0.14 11.9 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein ANAPC4_WD40 PF12894.7 ETS63721.1 - 0.00064 20.0 0.0 20 5.6 0.0 4.6 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Abhydrolase_1 PF00561.20 ETS63722.1 - 1.9e-19 70.3 0.7 1.1e-16 61.3 0.4 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETS63722.1 - 5.8e-18 66.3 9.6 8.2e-18 65.8 9.6 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS63722.1 - 3.1e-14 52.8 0.0 7e-14 51.7 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1100 PF06500.11 ETS63722.1 - 0.0034 16.2 0.0 0.0046 15.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_5 PF12695.7 ETS63722.1 - 0.0058 16.4 0.0 0.038 13.7 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family UPF0227 PF05728.12 ETS63722.1 - 0.012 15.5 0.0 0.037 14.0 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) ATP-synt_Z PF16594.5 ETS63722.1 - 0.88 9.1 3.6 0.33 10.5 0.5 1.9 2 0 0 2 2 2 0 Putative AtpZ or ATP-synthase-associated MFS_1 PF07690.16 ETS63723.1 - 2.7e-30 105.5 50.5 4.1e-30 104.9 50.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63723.1 - 9.8e-08 31.3 32.3 0.00015 20.7 12.0 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter DUF3382 PF11862.8 ETS63723.1 - 0.12 12.6 9.8 0.37 11.1 0.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) F-box-like PF12937.7 ETS63724.1 - 0.0047 16.8 0.1 0.061 13.2 0.0 2.9 2 1 0 2 2 2 1 F-box-like Peptidase_S24 PF00717.23 ETS63728.1 - 4.1e-09 36.3 0.1 3.1e-08 33.5 0.2 2.0 1 1 1 2 2 2 1 Peptidase S24-like Vma12 PF11712.8 ETS63728.1 - 0.13 12.3 0.1 0.2 11.7 0.1 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Rad60-SLD PF11976.8 ETS63729.1 - 6.6e-07 29.1 0.0 1.4e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like PGA2 PF07543.12 ETS63729.1 - 0.34 10.9 6.4 0.16 11.9 1.3 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 NOA36 PF06524.12 ETS63729.1 - 8.6 5.6 7.2 15 4.8 7.2 1.3 1 0 0 1 1 1 0 NOA36 protein bZIP_1 PF00170.21 ETS63730.1 - 0.00059 19.9 3.0 0.00059 19.9 3.0 2.1 3 0 0 3 3 3 1 bZIP transcription factor HeH PF12949.7 ETS63730.1 - 0.005 16.5 0.5 0.0097 15.6 0.5 1.5 1 0 0 1 1 1 1 HeH/LEM domain bZIP_2 PF07716.15 ETS63730.1 - 0.038 14.1 3.2 0.038 14.1 3.2 2.3 3 0 0 3 3 3 0 Basic region leucine zipper PGM_PMM_I PF02878.16 ETS63731.1 - 7.1e-37 126.2 0.2 1.1e-36 125.6 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ETS63731.1 - 2.9e-27 95.1 0.0 4.7e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ETS63731.1 - 4.5e-16 59.3 0.0 9.9e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ETS63731.1 - 1.7e-06 28.1 0.0 3.9e-06 26.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain ATG16 PF08614.11 ETS63732.1 - 0.00089 19.5 3.8 0.00089 19.5 3.8 3.9 3 1 1 4 4 4 1 Autophagy protein 16 (ATG16) DUF3492 PF11997.8 ETS63732.1 - 0.58 9.8 2.8 1.1 8.9 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) GNAT_acetyltr_2 PF13718.6 ETS63732.1 - 1.3 8.4 0.0 1.3 8.4 0.0 2.8 2 1 1 3 3 3 0 GNAT acetyltransferase 2 Homeobox_KN PF05920.11 ETS63733.1 - 1.2e-18 66.7 0.0 2.3e-18 65.8 0.0 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ETS63733.1 - 1.6e-05 24.7 0.0 3.1e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain PX PF00787.24 ETS63735.1 - 5.6e-16 58.5 0.1 2e-15 56.8 0.0 1.9 2 0 0 2 2 2 1 PX domain TFIIB PF00382.19 ETS63736.1 - 1.7e-31 108.1 0.3 1.7e-16 60.0 0.0 3.2 2 1 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ETS63736.1 - 1e-09 37.8 0.6 2e-09 36.8 0.6 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 ETS63736.1 - 0.00049 19.8 0.1 0.7 9.6 0.0 2.8 3 0 0 3 3 3 2 Cyclin, N-terminal domain Mob1_phocein PF03637.17 ETS63737.1 - 3.3e-21 76.0 0.0 5e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Mob1/phocein family Cwf_Cwc_15 PF04889.12 ETS63737.1 - 0.079 12.7 6.3 0.022 14.5 1.5 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2722 PF10846.8 ETS63737.1 - 1.2 8.0 5.9 2 7.3 5.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF202 PF02656.15 ETS63738.1 - 1.1e-20 73.8 0.3 1.1e-20 73.8 0.3 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF202) CsbD PF05532.12 ETS63739.1 - 8e-21 73.7 19.1 1.6e-11 43.9 7.6 2.0 1 1 1 2 2 2 2 CsbD-like HSP9_HSP12 PF04119.12 ETS63739.1 - 0.00018 21.8 0.9 0.00028 21.2 0.4 1.6 2 0 0 2 2 2 1 Heat shock protein 9/12 cobW PF02492.19 ETS63740.1 - 3.9e-50 169.9 4.5 3.7e-37 127.6 0.6 2.4 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain HIT PF01230.23 ETS63740.1 - 3e-24 85.6 0.2 1.2e-23 83.7 0.1 2.1 2 0 0 2 2 2 1 HIT domain CobW_C PF07683.14 ETS63740.1 - 5.3e-18 64.7 0.8 2.7e-13 49.7 0.1 2.9 2 0 0 2 2 2 2 Cobalamin synthesis protein cobW C-terminal domain DcpS_C PF11969.8 ETS63740.1 - 0.00019 21.9 0.0 0.00061 20.3 0.0 1.8 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding MeaB PF03308.16 ETS63740.1 - 0.00023 20.2 0.5 0.055 12.4 0.1 2.7 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ETS63740.1 - 0.0018 18.2 0.2 3 7.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ETS63740.1 - 0.0022 18.4 0.3 0.047 14.1 0.0 2.9 3 0 0 3 3 2 1 AAA ATPase domain CwfJ_C_1 PF04677.15 ETS63740.1 - 0.0025 17.7 0.0 0.0061 16.4 0.0 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 MobB PF03205.14 ETS63740.1 - 0.0039 17.1 0.0 0.0086 16.0 0.0 1.5 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 ETS63740.1 - 0.0075 16.3 0.2 0.03 14.3 0.1 2.0 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE GTP_EFTU PF00009.27 ETS63740.1 - 0.01 15.4 0.1 3.9 7.0 0.0 2.8 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain BUD22 PF09073.10 ETS63740.1 - 0.013 14.9 0.2 0.013 14.9 0.2 1.8 2 0 0 2 2 2 0 BUD22 AAA_33 PF13671.6 ETS63740.1 - 0.11 12.6 0.2 1.1 9.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain Cupin_8 PF13621.6 ETS63741.1 - 8.8e-60 202.5 0.0 1.1e-59 202.2 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Phenol_monoox PF04663.12 ETS63741.1 - 0.11 12.6 0.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Phenol hydroxylase conserved region FoP_duplication PF13865.6 ETS63743.1 - 0.12 12.9 11.8 0.28 11.8 11.8 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 PRR20 PF15708.5 ETS63743.1 - 0.26 11.2 5.1 0.65 9.9 5.1 1.6 1 0 0 1 1 1 0 Proline-rich protein family 20 API5 PF05918.11 ETS63743.1 - 5.1 5.8 5.6 7 5.3 5.6 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) zf-CCHC PF00098.23 ETS63744.1 - 0.054 13.6 0.5 0.15 12.2 0.5 1.8 1 0 0 1 1 1 0 Zinc knuckle FHA PF00498.26 ETS63745.1 - 6.3e-08 32.9 0.0 1.9e-07 31.3 0.0 1.8 1 1 0 1 1 1 1 FHA domain RVT_1 PF00078.27 ETS63745.1 - 0.025 14.1 0.0 0.043 13.3 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TFIID-18kDa PF02269.16 ETS63746.1 - 9.2e-14 51.3 0.1 7.4e-08 32.3 0.0 2.2 2 0 0 2 2 2 2 Transcription initiation factor IID, 18kD subunit RPAP1_C PF08620.10 ETS63747.1 - 1.7e-23 82.5 0.4 4.4e-23 81.2 0.4 1.7 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 ETS63747.1 - 1.3e-07 31.3 0.5 2.9e-07 30.2 0.5 1.7 1 0 0 1 1 1 1 RPAP1-like, N-terminal HEAT PF02985.22 ETS63747.1 - 0.054 13.8 0.1 6.5 7.3 0.0 3.4 2 0 0 2 2 2 0 HEAT repeat ETC_C1_NDUFA4 PF04800.12 ETS63748.1 - 1.2e-36 124.8 0.1 1.8e-36 124.3 0.1 1.2 1 0 0 1 1 1 1 ETC complex I subunit conserved region Proteasome PF00227.26 ETS63749.1 - 7.2e-41 139.8 0.0 8.3e-41 139.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit AAA PF00004.29 ETS63750.1 - 1.3e-39 135.7 0.0 2.7e-39 134.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS63750.1 - 1.4e-11 44.0 0.0 3.3e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 ETS63750.1 - 8e-07 28.9 0.0 1.8e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETS63750.1 - 4e-06 27.3 0.4 4.7e-05 23.8 0.4 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ETS63750.1 - 1.2e-05 25.4 0.1 7.4e-05 22.8 0.1 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETS63750.1 - 6.5e-05 23.2 0.3 0.0019 18.5 0.2 2.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ETS63750.1 - 0.00016 21.7 0.0 0.0003 20.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETS63750.1 - 0.00024 21.3 0.0 0.00044 20.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ETS63750.1 - 0.00025 21.2 0.0 0.00053 20.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ETS63750.1 - 0.00036 21.1 0.0 0.00081 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETS63750.1 - 0.00082 18.8 0.3 0.0026 17.2 0.2 1.8 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ETS63750.1 - 0.001 18.9 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TniB PF05621.11 ETS63750.1 - 0.0011 18.4 0.1 1.9 7.8 0.0 2.6 2 1 1 3 3 3 2 Bacterial TniB protein TIP49 PF06068.13 ETS63750.1 - 0.0025 17.1 0.0 0.0042 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 ETS63750.1 - 0.0026 17.5 0.1 0.0053 16.5 0.1 1.5 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETS63750.1 - 0.0034 17.7 0.0 0.0091 16.4 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 ETS63750.1 - 0.0043 16.6 0.1 0.035 13.7 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ETS63750.1 - 0.0044 17.3 0.0 0.0077 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ETS63750.1 - 0.005 16.7 0.3 0.24 11.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Sigma54_activ_2 PF14532.6 ETS63750.1 - 0.0074 16.4 0.0 0.015 15.4 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_7 PF12775.7 ETS63750.1 - 0.0077 15.8 0.0 0.021 14.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region Sigma54_activat PF00158.26 ETS63750.1 - 0.012 15.3 0.0 0.03 14.0 0.0 1.7 1 1 0 1 1 1 0 Sigma-54 interaction domain Parvo_NS1 PF01057.17 ETS63750.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 ETS63750.1 - 0.019 14.8 0.0 0.035 13.9 0.0 1.4 1 1 0 1 1 1 0 Bacterial dnaA protein TsaE PF02367.17 ETS63750.1 - 0.019 15.0 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 ETS63750.1 - 0.023 13.9 0.0 0.034 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Guanylate_kin PF00625.21 ETS63750.1 - 0.024 14.3 0.0 0.084 12.6 0.0 1.9 3 0 0 3 3 1 0 Guanylate kinase Rad17 PF03215.15 ETS63750.1 - 0.028 14.4 0.5 0.18 11.7 0.0 2.3 2 2 0 2 2 2 0 Rad17 P-loop domain ATPase PF06745.13 ETS63750.1 - 0.031 13.6 0.0 0.36 10.1 0.0 2.1 1 1 1 2 2 2 0 KaiC NACHT PF05729.12 ETS63750.1 - 0.038 13.9 0.1 0.078 12.9 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_17 PF13207.6 ETS63750.1 - 0.039 14.4 0.1 0.087 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain IPT PF01745.16 ETS63750.1 - 0.086 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase AAA_3 PF07726.11 ETS63750.1 - 0.087 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CPT PF07931.12 ETS63750.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein ABC_tran PF00005.27 ETS63750.1 - 0.14 12.7 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Cytidylate_kin PF02224.18 ETS63750.1 - 0.16 11.7 0.1 0.42 10.3 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase Zeta_toxin PF06414.12 ETS63750.1 - 0.16 11.2 0.1 0.28 10.4 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_6 PF12774.7 ETS63750.1 - 0.16 10.9 0.0 0.32 9.9 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Hydin_ADK PF17213.3 ETS63750.1 - 0.18 12.0 0.5 1.7 8.9 0.1 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain PhoH PF02562.16 ETS63750.1 - 0.2 11.1 0.0 0.37 10.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein YiaAB PF05360.14 ETS63751.1 - 0.38 11.0 5.9 0.31 11.3 0.9 3.0 2 0 0 2 2 2 0 yiaA/B two helix domain E_Pc_C PF06752.12 ETS63751.1 - 0.75 9.9 9.0 0.026 14.6 1.5 2.2 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus RunxI PF08504.11 ETS63751.1 - 0.96 10.2 6.1 1.1 10.0 0.4 3.1 2 0 0 2 2 2 0 Runx inhibition domain ATP-synt_C PF00137.21 ETS63752.1 - 5.7e-34 116.3 35.0 7.6e-22 77.4 15.5 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Med6 PF04934.14 ETS63753.1 - 3.3e-44 149.9 0.0 4.8e-44 149.4 0.0 1.3 1 1 0 1 1 1 1 MED6 mediator sub complex component BRO1 PF03097.18 ETS63755.1 - 7.9e-114 380.5 0.7 7.9e-114 380.5 0.7 1.9 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ETS63755.1 - 1.4e-55 188.7 10.9 2.2e-55 188.0 10.9 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV START PF01852.19 ETS63756.1 - 9e-07 28.5 0.0 2.3e-06 27.2 0.0 1.7 1 1 0 1 1 1 1 START domain Peptidase_S8 PF00082.22 ETS63757.1 - 2.9e-68 230.3 1.1 3.8e-68 230.0 0.2 1.6 2 0 0 2 2 2 1 Subtilase family TPPII PF12580.8 ETS63757.1 - 1.2e-51 174.9 0.5 1.2e-51 174.9 0.5 1.9 2 0 0 2 2 2 1 Tripeptidyl peptidase II Thioredoxin_13 PF18401.1 ETS63757.1 - 0.057 13.3 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Thioredoxin-like domain Glycos_transf_3 PF00591.21 ETS63758.1 - 2.8e-75 253.2 0.0 1.3e-69 234.6 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family, a/b domain TarH PF02203.15 ETS63758.1 - 0.1 12.5 1.3 0.19 11.7 1.2 1.4 1 1 0 1 1 1 0 Tar ligand binding domain homologue ETF PF01012.21 ETS63759.1 - 1.3e-43 149.0 0.2 1.8e-43 148.5 0.2 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain EF-hand_1 PF00036.32 ETS63760.1 - 1.1e-26 90.3 9.3 3.3e-08 32.5 0.0 5.2 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETS63760.1 - 1.5e-26 92.6 7.3 1.6e-17 63.7 1.0 3.1 2 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETS63760.1 - 8.3e-23 78.3 5.4 1.5e-06 27.7 0.1 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ETS63760.1 - 1e-13 50.1 7.9 0.00043 19.7 0.0 4.5 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 ETS63760.1 - 1.5e-13 50.4 6.8 0.00095 19.0 0.1 4.4 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_4 PF12763.7 ETS63760.1 - 2.6e-10 40.2 2.9 0.0063 16.4 0.0 4.0 2 1 2 4 4 4 4 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ETS63760.1 - 4.5e-05 23.7 1.4 0.013 15.8 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETS63760.1 - 0.00081 19.7 2.7 1.4 9.3 0.1 3.3 2 2 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_3 PF09069.11 ETS63760.1 - 0.046 14.1 0.1 0.22 12.0 0.0 2.0 2 0 0 2 2 2 0 EF-hand DUF1679 PF07914.11 ETS63760.1 - 0.05 12.5 0.5 0.97 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) Caleosin PF05042.13 ETS63760.1 - 0.32 10.9 3.5 20 5.0 0.0 3.2 2 1 0 3 3 3 0 Caleosin related protein zf-C3HC4_3 PF13920.6 ETS63761.1 - 9.3e-09 35.0 4.6 5.2e-07 29.4 0.9 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS63761.1 - 1.8e-07 30.9 3.9 7.7e-07 28.9 1.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS63761.1 - 3.2e-07 30.1 0.4 3.2e-07 30.1 0.4 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS63761.1 - 2e-06 27.7 1.7 2e-06 27.7 1.7 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETS63761.1 - 9.3e-06 25.9 5.7 1.6e-05 25.1 1.3 2.3 2 0 0 2 2 2 1 Ring finger domain Prok-RING_4 PF14447.6 ETS63761.1 - 6.4e-05 22.7 5.2 0.00081 19.2 1.6 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ETS63761.1 - 0.0001 22.2 1.2 0.0001 22.2 1.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETS63761.1 - 0.0096 16.1 2.2 0.0096 16.1 2.2 2.3 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING NOT2_3_5 PF04153.18 ETS63763.1 - 5.5e-34 117.1 1.9 5.5e-34 117.1 1.9 1.9 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Joubert PF15392.6 ETS63763.1 - 0.4 10.3 7.8 0.67 9.6 7.8 1.3 1 0 0 1 1 1 0 Joubert syndrome-associated TFIIA PF03153.13 ETS63763.1 - 4.7 7.1 20.6 0.13 12.2 12.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit ArfGap PF01412.18 ETS63764.1 - 1.6e-32 112.0 0.1 1.6e-32 112.0 0.1 2.0 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf zf-tcix PF14952.6 ETS63764.1 - 0.16 11.6 0.1 0.27 10.9 0.1 1.4 1 0 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding UQ_con PF00179.26 ETS63765.1 - 2.2e-43 147.3 0.0 2.8e-43 146.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 ETS63765.1 - 1.6e-23 82.3 1.3 2.8e-23 81.5 1.3 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain UBA_6 PF18039.1 ETS63765.1 - 6.8e-05 22.7 0.2 0.00012 21.9 0.2 1.3 1 0 0 1 1 1 1 UBA-like domain Prok-E2_B PF14461.6 ETS63765.1 - 0.015 15.0 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic E2 family B ATP_bind_1 PF03029.17 ETS63766.1 - 1.2e-65 221.6 0.0 7.5e-55 186.3 0.0 2.8 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 ETS63766.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain DNA_pol_delta_4 PF04081.13 ETS63767.1 - 4.4e-24 85.3 0.3 5.6e-24 85.0 0.3 1.3 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 Zn_clus PF00172.18 ETS63769.1 - 3.3e-06 27.1 9.5 3.3e-06 27.1 9.5 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS63769.1 - 0.0066 15.5 0.2 0.058 12.4 0.2 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain AsnC_trans_reg2 PF17805.1 ETS63770.1 - 0.021 15.0 0.0 1.3 9.2 0.0 2.6 2 0 0 2 2 2 0 AsnC-like ligand binding domain Nucleic_acid_bd PF13820.6 ETS63770.1 - 0.067 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Putative nucleic acid-binding region Sugar_tr PF00083.24 ETS63771.1 - 1.2e-30 106.8 25.7 7.9e-23 81.0 11.8 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETS63771.1 - 3.2e-28 98.7 49.7 1.8e-25 89.6 31.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 ETS63771.1 - 0.014 15.2 1.6 0.42 10.4 0.0 3.1 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) EMC3_TMCO1 PF01956.16 ETS63771.1 - 4.3 7.0 7.2 0.8 9.4 1.2 2.2 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Fungal_trans PF04082.18 ETS63772.1 - 1.1e-26 93.4 0.0 1.9e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS63772.1 - 1.2e-09 38.1 6.2 1.2e-09 38.1 6.2 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NYD-SP28_assoc PF14775.6 ETS63772.1 - 0.41 10.8 1.4 1.1 9.4 0.7 2.0 2 0 0 2 2 2 0 Sperm tail C-terminal domain CUE PF02845.16 ETS63773.1 - 1.3e-12 47.2 0.0 2.1e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 CUE domain WD40 PF00400.32 ETS63774.1 - 6.2e-18 64.8 9.8 6.8e-05 23.6 0.5 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63774.1 - 2.9e-06 27.5 0.0 2.3 8.6 0.0 5.3 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ETS63774.1 - 0.0018 16.9 0.0 0.054 12.0 0.0 2.6 3 0 0 3 3 3 1 Cytochrome D1 heme domain Lgl_C PF08596.10 ETS63774.1 - 0.037 12.7 0.1 0.067 11.9 0.1 1.3 1 0 0 1 1 1 0 Lethal giant larvae(Lgl) like, C-terminal DUF1218 PF06749.12 ETS63775.1 - 0.0086 16.6 0.2 0.067 13.7 0.2 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1218) Ni_hydr_CYTB PF01292.20 ETS63775.1 - 0.018 14.7 0.7 0.029 14.0 0.7 1.4 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 MGC-24 PF05283.11 ETS63776.1 - 0.011 16.2 3.0 0.011 16.2 3.0 1.9 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Phage_holin_3_6 PF07332.11 ETS63776.1 - 0.055 13.5 0.1 0.055 13.5 0.1 2.2 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III NYN PF01936.18 ETS63777.1 - 2.1e-26 93.2 0.0 4.3e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 NYN domain Cupin_5 PF06172.11 ETS63778.1 - 1.2e-31 109.8 0.0 1.6e-17 64.0 0.0 2.1 2 0 0 2 2 2 2 Cupin superfamily (DUF985) Mito_carr PF00153.27 ETS63782.1 - 4.6e-16 58.5 5.7 9.4e-06 25.5 0.0 5.4 4 1 1 5 5 5 5 Mitochondrial carrier protein Casein_kappa PF00997.18 ETS63783.1 - 0.0042 17.2 1.8 0.0074 16.4 1.8 1.4 1 0 0 1 1 1 1 Kappa casein Sec7_N PF12783.7 ETS63784.1 - 2.7e-44 150.9 4.9 3.1e-44 150.7 2.2 2.7 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 ETS63784.1 - 1.3e-36 125.9 0.1 3e-36 124.7 0.1 1.7 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Mon2_C PF16206.5 ETS63784.1 - 1.9e-21 76.0 4.0 2.2e-14 52.6 1.5 3.4 3 1 1 4 4 4 3 C-terminal region of Mon2 protein DUF1981 PF09324.10 ETS63784.1 - 0.0011 18.7 0.7 0.035 13.9 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) TPR_MLP1_2 PF07926.12 ETS63785.1 - 0.0053 16.8 48.8 0.14 12.2 14.7 3.4 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 ETS63785.1 - 0.045 11.3 36.8 0.0043 14.7 32.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 ETS63785.1 - 0.18 10.7 42.8 0.094 11.6 27.4 2.4 1 1 2 3 3 3 0 Spc7 kinetochore protein DUF4763 PF15960.5 ETS63785.1 - 0.18 11.1 36.1 0.017 14.4 21.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) DASH_Dam1 PF08653.10 ETS63785.1 - 0.29 11.0 1.2 0.96 9.3 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 CENP-F_leu_zip PF10473.9 ETS63785.1 - 0.32 11.0 48.2 1.2 9.2 12.3 3.2 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 ETS63785.1 - 0.46 10.2 40.4 0.3 10.8 15.3 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) HAUS-augmin3 PF14932.6 ETS63785.1 - 0.9 9.1 38.6 0.71 9.4 25.6 2.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 SHE3 PF17078.5 ETS63785.1 - 1.9 8.2 32.4 0.039 13.7 12.2 3.4 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 ATG16 PF08614.11 ETS63785.1 - 6.9 6.8 56.7 1.9 8.7 20.1 3.9 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) NTP_transf_3 PF12804.7 ETS63786.1 - 0.03 14.7 0.4 0.045 14.1 0.4 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain zf-rbx1 PF12678.7 ETS63787.1 - 1.3e-12 47.8 3.3 2.2e-12 47.0 3.3 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETS63787.1 - 2.9e-09 37.1 7.0 8e-09 35.7 7.0 1.7 1 1 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ETS63787.1 - 2.1e-06 27.6 1.3 4.1e-06 26.7 1.3 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETS63787.1 - 2.3e-06 27.4 3.2 4.3e-06 26.5 3.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS63787.1 - 3.1e-06 26.9 3.3 7.5e-06 25.7 3.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETS63787.1 - 2.8e-05 24.1 0.2 6.1e-05 23.0 0.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ETS63787.1 - 6.6e-05 22.7 2.4 0.0014 18.4 1.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS63787.1 - 0.00015 21.7 3.7 0.00046 20.1 3.9 1.7 1 1 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ETS63787.1 - 0.00016 21.2 0.8 0.00035 20.2 0.8 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ETS63787.1 - 0.00083 19.2 3.9 0.0021 17.9 4.0 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ETS63787.1 - 0.0035 17.5 2.3 0.0053 16.9 1.4 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ETS63787.1 - 0.0063 16.2 0.5 0.0063 16.2 0.5 2.2 2 0 0 2 2 2 1 RING-like zinc finger FANCL_C PF11793.8 ETS63787.1 - 0.0069 16.5 0.4 0.014 15.5 0.4 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING-like PF08746.11 ETS63787.1 - 0.13 12.6 2.2 0.24 11.7 2.2 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 ETS63787.1 - 1.3 8.9 2.8 2.1 8.2 1.3 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain SET PF00856.28 ETS63788.1 - 1.7e-09 38.3 0.2 4.2e-08 33.8 0.0 2.9 2 1 0 2 2 2 1 SET domain DUF2076 PF09849.9 ETS63790.1 - 3.5e-08 33.8 11.5 5e-08 33.3 11.5 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 ETS63790.1 - 0.00063 19.8 5.8 0.0011 19.0 5.8 1.4 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 ETS63790.1 - 0.03 14.3 3.1 0.059 13.4 3.1 1.5 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, TFIIA PF03153.13 ETS63790.1 - 0.64 10.0 6.2 0.7 9.8 6.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA PF00004.29 ETS63791.1 - 1.6e-44 151.6 0.1 4.5e-44 150.1 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ETS63791.1 - 1.3e-08 34.7 0.2 8e-08 32.1 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 ETS63791.1 - 2.2e-08 34.2 0.7 6.4e-08 32.7 0.1 2.1 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETS63791.1 - 3.1e-08 34.2 0.2 3.1e-05 24.4 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 ETS63791.1 - 7.6e-08 32.7 0.0 1.8e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 ETS63791.1 - 4.4e-06 26.4 0.1 2e-05 24.3 0.0 2.2 2 0 0 2 2 1 1 AAA+ lid domain DUF815 PF05673.13 ETS63791.1 - 4.9e-06 25.9 0.1 1.9e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ETS63791.1 - 0.00017 22.1 0.0 0.0028 18.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETS63791.1 - 0.00019 21.7 3.2 0.01 16.1 0.1 3.0 3 1 1 4 4 2 1 AAA domain NTPase_1 PF03266.15 ETS63791.1 - 0.00024 21.0 0.2 0.0038 17.2 0.0 2.6 3 0 0 3 3 3 1 NTPase RuvB_N PF05496.12 ETS63791.1 - 0.00027 20.7 0.0 0.00077 19.2 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 ETS63791.1 - 0.00032 20.5 0.1 0.00097 18.9 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETS63791.1 - 0.00053 20.3 0.4 0.0019 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 ETS63791.1 - 0.0014 17.9 0.0 0.0028 16.9 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_14 PF13173.6 ETS63791.1 - 0.0014 18.7 0.0 0.0046 17.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ETS63791.1 - 0.0019 18.2 0.0 0.005 16.8 0.0 1.6 1 1 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETS63791.1 - 0.0022 18.4 0.0 0.0079 16.6 0.0 1.9 2 0 0 2 2 1 1 RNA helicase TniB PF05621.11 ETS63791.1 - 0.0022 17.4 0.6 0.65 9.4 0.0 3.1 3 0 0 3 3 3 1 Bacterial TniB protein AAA_7 PF12775.7 ETS63791.1 - 0.0027 17.3 0.1 0.017 14.7 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 ETS63791.1 - 0.005 17.0 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETS63791.1 - 0.007 15.8 0.0 0.017 14.5 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETS63791.1 - 0.0083 16.0 0.0 0.019 14.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETS63791.1 - 0.0084 16.0 0.1 0.072 13.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain IstB_IS21 PF01695.17 ETS63791.1 - 0.011 15.4 0.1 0.032 14.0 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_11 PF13086.6 ETS63791.1 - 0.014 15.2 0.1 0.16 11.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETS63791.1 - 0.024 14.4 0.2 0.049 13.3 0.2 1.6 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ETS63791.1 - 0.024 14.5 1.1 0.38 10.6 0.0 2.9 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea Bac_DnaA PF00308.18 ETS63791.1 - 0.042 13.7 0.1 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial dnaA protein AFG1_ATPase PF03969.16 ETS63791.1 - 0.049 12.5 0.2 0.17 10.8 0.0 1.9 2 0 0 2 2 2 0 AFG1-like ATPase HTH_Tnp_1_2 PF13022.6 ETS63791.1 - 0.06 13.5 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix of insertion element transposase Parvo_NS1 PF01057.17 ETS63791.1 - 0.064 12.3 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 ETS63791.1 - 0.082 12.6 0.2 1.4 8.6 0.0 2.8 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_29 PF13555.6 ETS63791.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ETS63791.1 - 0.12 12.9 2.3 0.76 10.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ETS63791.1 - 0.12 11.7 0.0 0.62 9.4 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_19 PF13245.6 ETS63791.1 - 0.25 11.7 1.3 0.4 11.0 0.1 1.9 2 0 0 2 2 1 0 AAA domain AAA_25 PF13481.6 ETS63791.1 - 0.41 10.2 3.8 0.2 11.2 0.5 2.1 2 1 0 2 2 2 0 AAA domain P5CR_dimer PF14748.6 ETS63792.1 - 1.7e-37 127.8 3.3 1.7e-37 127.8 3.3 1.8 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ETS63792.1 - 2e-13 50.8 0.5 1.6e-11 44.7 0.5 2.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GDA1_CD39 PF01150.17 ETS63793.1 - 2.2e-89 300.1 0.0 2.9e-89 299.7 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 ETS63793.1 - 0.23 10.9 0.0 0.38 10.1 0.0 1.3 1 0 0 1 1 1 0 Ppx/GppA phosphatase family NAD_kinase PF01513.21 ETS63794.1 - 1.5e-73 247.6 0.0 4e-73 246.1 0.0 1.7 1 1 0 1 1 1 1 ATP-NAD kinase NOA36 PF06524.12 ETS63794.1 - 0.9 8.8 34.0 0.034 13.5 15.0 2.3 2 0 0 2 2 2 0 NOA36 protein zf-C2H2 PF00096.26 ETS63796.1 - 1e-08 35.2 14.6 0.00034 20.9 1.6 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS63796.1 - 0.006 17.3 11.9 0.25 12.3 3.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETS63796.1 - 0.011 16.1 7.6 0.34 11.4 1.7 3.8 3 0 0 3 3 3 0 Zinc-finger double domain DUF3268 PF11672.8 ETS63796.1 - 0.052 13.9 0.3 0.088 13.1 0.3 1.3 1 0 0 1 1 1 0 zinc-finger-containing domain zf-C2HC_2 PF13913.6 ETS63796.1 - 2.5 8.1 7.3 3.3 7.7 0.6 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 ETS63796.1 - 7.7 6.4 12.0 1.9 8.3 0.2 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type PH_9 PF15410.6 ETS63797.1 - 9e-30 103.5 0.0 2.2e-29 102.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Sec7 PF01369.20 ETS63797.1 - 9.7e-28 97.1 0.1 2.1e-27 96.0 0.1 1.5 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 ETS63797.1 - 0.00025 21.5 0.0 0.0013 19.2 0.0 2.2 1 1 0 1 1 1 1 PH domain Rrp40_N PF18311.1 ETS63797.1 - 0.22 11.5 3.2 3.8 7.5 0.5 3.0 2 0 0 2 2 2 0 Exosome complex exonuclease Rrp40 N-terminal domain Lzipper-MIP1 PF14389.6 ETS63797.1 - 0.38 11.1 5.0 30 5.0 3.1 2.9 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Sec2p PF06428.11 ETS63798.1 - 2.5e-18 65.8 9.2 2.5e-18 65.8 9.2 2.9 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF4763 PF15960.5 ETS63798.1 - 0.036 13.4 0.3 0.036 13.4 0.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) AroM PF07302.11 ETS63798.1 - 0.085 12.2 0.7 0.83 9.0 0.1 2.4 2 0 0 2 2 2 0 AroM protein DUF713 PF05218.14 ETS63798.1 - 0.36 10.5 7.1 0.14 11.8 0.2 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF713) DUF948 PF06103.11 ETS63798.1 - 0.82 10.0 8.5 7.2 7.0 0.5 3.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TolA_bind_tri PF16331.5 ETS63798.1 - 3.1 7.9 10.8 0.15 12.2 1.9 3.1 2 1 1 3 3 3 0 TolA binding protein trimerisation Bacillus_HBL PF05791.11 ETS63798.1 - 3.1 7.6 8.0 3.6 7.4 2.2 2.7 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF16 PF01519.16 ETS63798.1 - 4.6 7.8 6.6 1.5 9.3 1.1 2.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 NAD_Gly3P_dh_N PF01210.23 ETS63800.1 - 5.9e-48 162.8 0.1 1.2e-47 161.8 0.1 1.4 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ETS63800.1 - 7e-48 162.5 0.0 1.3e-47 161.6 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 ETS63800.1 - 0.0012 19.4 0.4 0.026 15.1 0.4 2.5 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent RCC1 PF00415.18 ETS63801.1 - 8.4e-41 138.4 7.5 1.8e-06 28.5 0.1 7.9 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETS63801.1 - 6.9e-28 95.8 22.6 1.8e-07 30.8 0.1 6.9 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat PGA2 PF07543.12 ETS63801.1 - 4.2 7.3 6.1 8.2 6.4 6.1 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 Glyco_hydro_38N PF01074.22 ETS63802.1 - 4e-79 266.0 1.8 6.2e-79 265.4 1.8 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ETS63802.1 - 4.2e-43 147.9 0.0 7.5e-43 147.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ETS63802.1 - 5.1e-28 97.1 0.0 1.2e-27 95.9 0.0 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ETS63802.1 - 1.3e-09 38.0 0.1 4.6e-09 36.3 0.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Con-6 PF10346.9 ETS63802.1 - 2.7e-07 30.5 0.1 5.4e-07 29.5 0.1 1.5 1 0 0 1 1 1 1 Conidiation protein 6 Glyco_hydro_57 PF03065.15 ETS63802.1 - 0.00041 19.6 0.0 0.00072 18.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Tannase PF07519.11 ETS63803.1 - 1.7e-75 254.8 0.1 1.3e-74 251.8 0.1 2.2 1 1 0 1 1 1 1 Tannase and feruloyl esterase Hydrolase_4 PF12146.8 ETS63803.1 - 3.1e-06 26.6 0.0 0.00063 19.1 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETS63803.1 - 0.00037 20.0 0.0 0.11 11.9 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 ETS63803.1 - 0.047 13.3 0.1 0.12 12.0 0.0 1.6 2 0 0 2 2 2 0 Putative esterase Pkinase PF00069.25 ETS63805.1 - 1.1e-61 208.6 0.0 1.9e-61 207.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63805.1 - 3e-24 85.7 0.0 4.1e-24 85.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS63805.1 - 0.00016 21.1 0.0 0.00028 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETS63805.1 - 0.018 15.0 0.0 0.067 13.1 0.0 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 ETS63805.1 - 0.1 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase FTA2 PF13095.6 ETS63805.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ETS63805.1 - 0.17 11.2 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RabGAP-TBC PF00566.18 ETS63806.1 - 2.5e-35 122.1 0.0 3.5e-35 121.6 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain zf-RING_5 PF14634.6 ETS63806.1 - 0.0057 16.6 0.1 0.0057 16.6 0.1 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETS63806.1 - 0.095 12.7 0.4 0.32 11.1 0.1 2.1 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 ETS63806.1 - 0.13 12.7 0.2 0.38 11.1 0.2 1.8 1 0 0 1 1 1 0 Ring finger domain Ribosomal_L30 PF00327.20 ETS63807.1 - 2.5e-11 43.3 0.0 3.8e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e BBS2_C PF14782.6 ETS63807.1 - 0.14 10.9 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, C-terminal Drc1-Sld2 PF11719.8 ETS63809.1 - 6e-09 36.0 15.9 6e-09 36.0 15.9 2.4 2 2 0 2 2 2 1 DNA replication and checkpoint protein NAD_binding_6 PF08030.12 ETS63810.1 - 0.00024 21.3 0.0 0.0005 20.2 0.0 1.6 1 0 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ETS63810.1 - 0.00056 20.5 0.0 0.0013 19.3 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ETS63810.1 - 0.11 12.9 0.0 0.75 10.2 0.0 2.1 1 1 1 2 2 2 0 Oxidoreductase FAD-binding domain Pkinase PF00069.25 ETS63811.1 - 2.2e-27 96.1 0.0 2.8e-27 95.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63811.1 - 5.2e-16 58.7 0.0 6.9e-16 58.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS63811.1 - 1.1e-09 37.6 0.1 1.7e-09 37.0 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETS63811.1 - 0.00023 21.2 0.2 0.0081 16.1 0.0 2.9 3 0 0 3 3 3 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ETS63811.1 - 0.039 12.9 0.1 0.059 12.3 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 ETS63811.1 - 0.067 12.5 0.1 0.14 11.5 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PCI PF01399.27 ETS63812.1 - 1.1e-16 61.2 0.0 4.6e-16 59.2 0.0 2.1 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 ETS63812.1 - 7.4e-14 51.6 0.9 1.8e-13 50.3 0.9 1.7 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Ntox34 PF15606.6 ETS63812.1 - 0.026 14.6 0.1 2.9 8.1 0.0 2.9 2 0 0 2 2 2 0 Bacterial toxin 34 CLN3 PF02487.17 ETS63812.1 - 0.061 12.4 1.5 0.097 11.7 1.5 1.2 1 0 0 1 1 1 0 CLN3 protein DDHD PF02862.17 ETS63812.1 - 0.089 12.9 0.7 0.14 12.3 0.7 1.5 1 0 0 1 1 1 0 DDHD domain Ndc1_Nup PF09531.10 ETS63812.1 - 0.091 11.4 2.5 0.14 10.8 2.5 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4228 PF14009.6 ETS63812.1 - 0.098 13.0 2.9 0.21 12.0 2.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) RNA_pol_Rpc4 PF05132.14 ETS63812.1 - 0.4 11.1 4.5 0.81 10.1 4.5 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Vfa1 PF08432.10 ETS63812.1 - 0.48 10.7 12.6 1.1 9.6 12.6 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Serinc PF03348.15 ETS63812.1 - 0.58 9.0 1.4 0.85 8.5 1.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RR_TM4-6 PF06459.12 ETS63812.1 - 1.6 8.5 13.8 3.4 7.4 13.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ETS63812.1 - 2.2 7.1 5.1 4.2 6.3 5.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETS63812.1 - 3.4 6.3 7.7 5.3 5.7 7.7 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 ETS63812.1 - 5 6.8 6.6 9 6.0 6.6 1.4 1 0 0 1 1 1 0 Connexin eIF3_subunit PF08597.10 ETS63812.1 - 9.1 6.1 24.6 1.2 9.0 18.9 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit ANTH PF07651.16 ETS63813.1 - 3.7e-75 252.5 0.2 3.7e-75 252.5 0.2 2.4 3 0 0 3 3 3 1 ANTH domain I_LWEQ PF01608.17 ETS63813.1 - 8.3e-55 185.2 9.5 8.3e-55 185.2 9.5 5.0 4 1 0 4 4 4 2 I/LWEQ domain ENTH PF01417.20 ETS63813.1 - 7.4e-07 29.3 0.3 1.4e-05 25.1 0.0 3.0 2 0 0 2 2 2 1 ENTH domain TcdB_N PF12918.7 ETS63813.1 - 0.03 14.6 0.1 0.11 12.9 0.1 2.0 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain SUR7 PF06687.12 ETS63814.1 - 8.6e-24 84.4 10.0 1.2e-23 83.9 10.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family MMPL PF03176.15 ETS63814.1 - 0.3 10.0 3.1 0.56 9.1 3.1 1.3 1 0 0 1 1 1 0 MMPL family Clc-like PF07062.12 ETS63814.1 - 5.9 6.3 6.5 12 5.3 6.5 1.5 1 0 0 1 1 1 0 Clc-like Ion_trans PF00520.31 ETS63815.1 - 0.0062 15.8 0.1 0.0083 15.4 0.1 1.1 1 0 0 1 1 1 1 Ion transport protein Homeodomain PF00046.29 ETS63816.1 - 6.7e-13 48.3 0.2 1.7e-12 47.0 0.2 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ETS63816.1 - 2e-05 24.4 0.3 4.5e-05 23.3 0.3 1.6 1 0 0 1 1 1 1 Homeobox KN domain Ustilago_mating PF05722.12 ETS63817.1 - 2.7e-94 315.9 4.7 3.7e-94 315.4 4.7 1.2 1 0 0 1 1 1 1 Ustilago B locus mating-type protein Homeobox_KN PF05920.11 ETS63817.1 - 1.6e-16 59.9 4.2 8.8e-16 57.5 4.2 2.3 1 1 0 1 1 1 1 Homeobox KN domain Sas10_Utp3 PF04000.15 ETS63818.1 - 2.4e-17 63.3 0.1 7.8e-17 61.7 0.1 1.9 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Ydc2-catalyt PF09159.10 ETS63818.1 - 0.25 11.0 4.6 0.52 10.0 4.6 1.5 1 1 0 1 1 1 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 HA2 PF04408.23 ETS63820.1 - 1.3e-16 60.8 0.0 1.3e-16 60.8 0.0 3.6 2 1 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETS63820.1 - 4.4e-15 56.0 0.0 1.3e-14 54.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS63820.1 - 6.9e-11 42.2 0.0 1.4e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase OB_NTP_bind PF07717.16 ETS63820.1 - 4.6e-09 36.5 0.1 1e-08 35.4 0.1 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 ETS63820.1 - 2.3e-07 31.1 0.1 1.3e-06 28.7 0.1 2.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ETS63820.1 - 0.042 13.8 0.1 0.14 12.0 0.1 1.9 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea UTP15_C PF09384.10 ETS63820.1 - 0.042 13.5 0.4 0.13 12.0 0.4 1.8 1 0 0 1 1 1 0 UTP15 C terminal ATPase PF06745.13 ETS63820.1 - 0.042 13.2 0.0 0.1 12.0 0.0 1.6 1 0 0 1 1 1 0 KaiC AAA_23 PF13476.6 ETS63820.1 - 0.17 12.4 0.0 0.17 12.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain RuvA_C PF07499.13 ETS63820.1 - 0.48 10.9 3.9 0.8 10.2 0.4 3.3 3 1 0 3 3 3 0 RuvA, C-terminal domain Matrix PF00661.21 ETS63821.1 - 0.084 11.6 0.0 0.098 11.4 0.0 1.1 1 0 0 1 1 1 0 Viral matrix protein DUF883 PF05957.13 ETS63822.1 - 6.8e-06 26.6 36.2 0.036 14.7 2.9 4.0 1 1 3 4 4 4 4 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 ETS63822.1 - 0.015 15.8 38.1 0.08 13.5 3.1 4.6 1 1 3 4 4 4 0 YtxH-like protein Apolipoprotein PF01442.18 ETS63822.1 - 0.032 14.1 34.2 0.87 9.4 24.2 2.4 1 1 1 2 2 2 0 Apolipoprotein A1/A4/E domain DivIVA PF05103.13 ETS63822.1 - 1.2 9.2 45.9 0.41 10.7 10.8 4.6 1 1 3 4 4 4 0 DivIVA protein Chlorosome_CsmC PF11098.8 ETS63822.1 - 1.4 8.9 33.5 0.89 9.5 3.8 4.4 1 1 4 5 5 5 0 Chlorosome envelope protein C AI-2E_transport PF01594.16 ETS63822.1 - 1.5 7.9 2.1 18 4.3 0.3 2.2 2 0 0 2 2 2 0 AI-2E family transporter REF PF05755.12 ETS63822.1 - 2.5 7.9 25.0 27 4.5 12.7 3.7 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) ApoLp-III PF07464.11 ETS63822.1 - 4.5 7.3 35.3 24 5.0 14.3 3.4 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) CS PF04969.16 ETS63823.1 - 0.021 15.9 0.0 0.09 13.8 0.0 2.1 1 1 0 1 1 1 0 CS domain SNF2_N PF00176.23 ETS63824.1 - 6.1e-61 206.1 0.0 8.8e-61 205.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS63824.1 - 1.9e-11 44.3 0.0 4.2e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS63824.1 - 7.6e-07 29.3 0.0 0.00022 21.3 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 ETS63824.1 - 0.00057 19.8 0.5 0.00057 19.8 0.5 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETS63824.1 - 0.00088 19.1 0.5 0.0024 17.7 0.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS63824.1 - 0.19 11.6 1.1 0.56 10.1 1.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETS63824.1 - 0.22 11.4 4.6 0.045 13.6 0.9 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETS63824.1 - 0.24 11.8 2.0 0.68 10.3 2.0 1.8 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETS63824.1 - 0.8 9.6 5.7 3.3 7.6 5.7 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PNP_UDP_1 PF01048.20 ETS63825.1 - 1.1e-37 129.5 0.4 1.3e-37 129.3 0.4 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily MMR_HSR1 PF01926.23 ETS63826.1 - 4.9e-14 52.4 0.0 1.8e-13 50.6 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETS63826.1 - 7.7e-05 22.3 0.0 0.00049 19.6 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ETS63826.1 - 0.00018 21.5 0.0 0.058 13.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ETS63826.1 - 0.0019 18.3 0.1 0.0074 16.4 0.1 1.9 2 0 0 2 2 2 1 Dynamin family Roc PF08477.13 ETS63826.1 - 0.19 12.0 0.2 0.72 10.1 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ETS63826.1 - 0.22 10.8 0.0 0.62 9.3 0.0 1.8 2 0 0 2 2 2 0 Septin Metal_resist PF13801.6 ETS63826.1 - 2.1 8.6 6.1 0.65 10.2 0.7 2.7 3 0 0 3 3 3 0 Heavy-metal resistance NIF PF03031.18 ETS63827.1 - 4.6e-22 78.5 0.0 1.4e-21 76.9 0.0 1.9 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase AATF-Che1 PF13339.6 ETS63827.1 - 0.38 11.4 4.7 0.19 12.4 0.4 2.3 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor Macoilin PF09726.9 ETS63827.1 - 1.2 7.6 9.9 0.92 8.0 1.6 2.1 2 0 0 2 2 2 0 Macoilin family DPBB_1 PF03330.18 ETS63828.1 - 5.3e-05 23.4 0.4 0.00011 22.4 0.4 1.6 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ETS63828.1 - 0.008 16.0 0.2 0.013 15.4 0.2 1.5 1 0 0 1 1 1 1 Barwin family SOG2 PF10428.9 ETS63828.1 - 0.009 15.3 13.3 0.009 15.3 13.3 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein Miga PF10265.9 ETS63828.1 - 0.17 10.9 3.1 0.22 10.4 3.1 1.1 1 0 0 1 1 1 0 Mitoguardin Sporozoite_P67 PF05642.11 ETS63828.1 - 3 5.8 10.9 3.2 5.7 10.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Mucin PF01456.17 ETS63828.1 - 3.2 7.7 20.7 0.091 12.8 14.2 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein Apt1 PF10351.9 ETS63828.1 - 3.5 6.4 9.8 4.7 5.9 9.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Suf PF05843.14 ETS63828.1 - 4.5 7.2 7.2 7.3 6.5 7.2 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PIP5K PF01504.18 ETS63829.1 - 3.3e-43 147.9 0.1 1.3e-34 119.7 0.1 2.5 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 ETS63829.1 - 3e-23 82.2 0.0 4.7e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 ETS63829.1 - 4.4e-15 55.6 10.2 1.3e-14 54.1 10.2 1.8 1 0 0 1 1 1 1 FYVE zinc finger CNDH2_C PF16858.5 ETS63829.1 - 0.15 11.9 3.7 0.4 10.5 3.7 1.6 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term IBR PF01485.21 ETS63829.1 - 0.64 10.3 3.7 2 8.7 3.7 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Cwf_Cwc_15 PF04889.12 ETS63829.1 - 1 9.0 14.0 5 6.8 14.0 2.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 ETS63829.1 - 5.1 5.1 11.3 9.4 4.2 11.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi Cpn60_TCP1 PF00118.24 ETS63830.1 - 4.9e-160 533.4 1.5 5.6e-160 533.2 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family A_deaminase PF00962.22 ETS63831.1 - 3.4e-33 115.4 0.1 5.3e-33 114.7 0.1 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase HAGH_C PF16123.5 ETS63832.1 - 1e-16 61.2 0.1 2.3e-16 60.1 0.1 1.6 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 ETS63832.1 - 2.5e-12 47.2 2.3 1.1e-11 45.2 2.3 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily LRR_6 PF13516.6 ETS63832.1 - 1.2e-07 31.2 0.5 3.5 7.9 0.0 5.9 6 0 0 6 6 6 3 Leucine Rich repeat F-box-like PF12937.7 ETS63832.1 - 6.8e-07 29.1 0.1 2e-06 27.6 0.1 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ETS63832.1 - 1.7e-06 28.2 6.2 2.1 8.9 0.1 6.0 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) F-box PF00646.33 ETS63832.1 - 0.00066 19.5 4.2 0.047 13.6 0.5 3.4 2 1 0 2 2 2 1 F-box domain LRR_1 PF00560.33 ETS63832.1 - 0.026 15.0 8.4 42 5.2 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 ETS63832.1 - 0.68 9.7 2.7 17 5.3 0.2 3.7 4 1 0 4 4 4 0 Leucine rich repeat Ribosomal_S7 PF00177.21 ETS63834.1 - 1.9e-37 128.2 1.6 2.5e-37 127.8 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e WD40 PF00400.32 ETS63835.1 - 1.3e-39 133.5 15.1 1e-06 29.4 0.0 8.9 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63835.1 - 7.3e-19 67.9 0.0 3.5e-06 27.2 0.0 5.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 ETS63835.1 - 5e-06 26.3 0.3 9.2e-06 25.4 0.3 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 ETS63835.1 - 0.00096 19.1 0.0 0.048 13.5 0.0 2.6 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETS63835.1 - 0.0079 14.9 0.0 0.73 8.4 0.0 2.8 3 0 0 3 3 3 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETS63835.1 - 0.07 12.5 0.0 4.3 6.6 0.0 2.5 2 0 0 2 2 2 0 WD40-like domain LAP1C PF05609.12 ETS63835.1 - 0.6 9.1 18.3 1.2 8.1 18.3 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Aminotran_1_2 PF00155.21 ETS63836.1 - 4.8e-91 305.6 0.0 5.6e-91 305.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II K-box PF01486.17 ETS63836.1 - 0.16 12.2 0.1 0.3 11.3 0.1 1.4 1 0 0 1 1 1 0 K-box region ABC_membrane PF00664.23 ETS63838.1 - 3e-40 138.6 5.9 3.9e-40 138.2 5.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ETS63838.1 - 1.9e-35 122.3 0.0 2.3e-34 118.8 0.0 2.3 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ETS63838.1 - 1.4e-05 24.7 0.0 0.0015 18.0 0.0 2.4 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 ETS63838.1 - 0.00098 19.6 0.0 0.0088 16.5 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ETS63838.1 - 0.006 16.4 0.1 0.081 12.7 0.0 2.2 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ETS63838.1 - 0.011 16.1 0.0 0.027 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ETS63838.1 - 0.023 14.4 0.1 0.057 13.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ETS63838.1 - 0.027 14.7 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ETS63838.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ETS63838.1 - 0.072 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain Abhydrolase_6 PF12697.7 ETS63839.1 - 0.0029 18.3 0.8 0.0029 18.3 0.8 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ETS63839.1 - 0.15 11.9 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DNA_pol_B_thumb PF14791.6 ETS63840.1 - 7.2e-20 70.9 0.1 1.6e-19 69.8 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 ETS63840.1 - 6.9e-09 35.9 0.0 2.5e-08 34.1 0.0 1.9 1 1 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 ETS63840.1 - 7.1e-07 29.5 0.1 2.5e-06 27.7 0.1 2.0 1 1 0 1 1 1 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 ETS63840.1 - 0.00037 20.3 0.0 0.00085 19.1 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda SNARE PF05739.19 ETS63841.1 - 8e-16 57.8 0.1 1.6e-15 56.8 0.1 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 ETS63841.1 - 2.3e-08 33.0 0.0 1.2e-07 30.7 0.0 2.2 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 ETS63841.1 - 6.3e-08 32.5 9.5 0.00019 21.2 0.6 2.3 2 0 0 2 2 2 2 Syntaxin Syntaxin-18_N PF10496.9 ETS63841.1 - 0.00062 20.0 1.6 0.0012 19.0 0.2 2.2 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus DUF3829 PF12889.7 ETS63841.1 - 0.0051 16.3 4.8 0.11 11.9 0.9 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3829) DUF4618 PF15397.6 ETS63841.1 - 0.021 14.3 1.3 0.3 10.5 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) FlaC_arch PF05377.11 ETS63841.1 - 0.043 14.2 1.4 0.23 11.9 1.4 2.2 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Prominin PF05478.11 ETS63841.1 - 0.046 11.7 0.6 0.094 10.7 0.6 1.5 1 0 0 1 1 1 0 Prominin DUF3347 PF11827.8 ETS63841.1 - 0.15 12.2 0.2 0.15 12.2 0.2 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3347) DUF16 PF01519.16 ETS63841.1 - 0.29 11.6 3.0 0.3 11.6 0.5 2.1 2 1 1 3 3 3 0 Protein of unknown function DUF16 DUF1664 PF07889.12 ETS63841.1 - 0.3 11.2 2.9 0.84 9.7 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Cor1 PF04803.12 ETS63841.1 - 0.45 10.7 7.3 14 5.9 0.1 2.4 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region BLOC1_2 PF10046.9 ETS63841.1 - 0.6 10.4 3.9 1.3 9.4 0.4 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF148 PF02520.17 ETS63841.1 - 0.84 9.8 8.8 0.48 10.6 1.7 2.9 2 1 0 2 2 2 0 Domain of unknown function DUF148 SlyX PF04102.12 ETS63841.1 - 1.4 9.6 6.9 0.85 10.3 0.9 3.1 3 1 1 4 4 4 0 SlyX Spectrin PF00435.21 ETS63841.1 - 1.5 9.4 4.8 5.7 7.5 0.3 3.3 2 1 1 3 3 3 0 Spectrin repeat Fib_alpha PF08702.10 ETS63841.1 - 9.3 6.4 9.2 9.1 6.5 1.3 3.1 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family RRM_1 PF00076.22 ETS63842.1 - 8.9e-15 54.3 0.0 1.2e-07 31.4 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETS63842.1 - 0.00015 21.8 0.0 0.00037 20.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif DUF4533 PF15047.6 ETS63842.1 - 0.13 11.8 1.3 0.37 10.3 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4533) Fungal_trans_2 PF11951.8 ETS63842.1 - 0.17 10.6 0.2 0.3 9.8 0.2 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain Pkinase PF00069.25 ETS63843.1 - 4e-65 219.8 0.0 5.1e-65 219.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63843.1 - 1.3e-28 100.0 0.0 1.7e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ETS63843.1 - 1.5e-14 54.4 1.8 9.3e-14 51.9 0.1 2.9 2 0 0 2 2 2 1 Protein kinase C terminal domain C2 PF00168.30 ETS63843.1 - 6.9e-09 35.9 0.1 1.2e-07 31.9 0.1 2.3 1 1 0 1 1 1 1 C2 domain Kinase-like PF14531.6 ETS63843.1 - 2e-07 30.6 0.0 1.5e-06 27.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ETS63843.1 - 0.0027 16.7 0.0 0.0054 15.7 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ETS63843.1 - 0.0052 16.4 0.1 0.56 9.8 0.1 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ETS63843.1 - 0.054 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ETS63843.1 - 0.15 11.4 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CAF20 PF17052.5 ETS63844.1 - 0.14 12.3 0.2 0.32 11.2 0.2 1.5 1 0 0 1 1 1 0 Cap associated factor DUF896 PF05979.12 ETS63844.1 - 0.4 10.6 0.1 0.4 10.6 0.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) SGS PF05002.15 ETS63845.1 - 2.6e-29 101.1 0.7 4.6e-29 100.4 0.7 1.4 1 0 0 1 1 1 1 SGS domain CS PF04969.16 ETS63845.1 - 1.8e-13 51.3 0.0 2.5e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 CS domain DUF2057 PF09829.9 ETS63845.1 - 0.0034 17.6 0.5 0.0088 16.2 0.2 1.8 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2057) ISAV_HA PF06215.11 ETS63845.1 - 0.091 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin Alg6_Alg8 PF03155.15 ETS63846.1 - 2.8e-155 518.0 26.5 2.4e-151 505.0 22.3 2.0 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family PUF PF00806.19 ETS63847.1 - 8.5e-59 192.1 0.0 7.8e-08 31.6 0.0 8.4 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat LOB PF03195.14 ETS63847.1 - 0.0071 16.9 0.6 1.8 9.2 0.1 2.9 3 1 0 3 3 3 2 Lateral organ boundaries (LOB) domain DUF4736 PF15883.5 ETS63847.1 - 0.089 12.5 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4736) Phosducin PF02114.16 ETS63848.1 - 8.3e-13 47.9 0.0 3.2e-09 36.1 0.0 2.3 2 0 0 2 2 2 2 Phosducin FoP_duplication PF13865.6 ETS63848.1 - 0.037 14.6 0.6 0.037 14.6 0.6 2.6 3 0 0 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 Thioredoxin PF00085.20 ETS63848.1 - 0.056 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin GST_N_3 PF13417.6 ETS63849.1 - 7.7e-07 29.4 0.0 1.4e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETS63849.1 - 0.00013 22.2 0.0 0.00021 21.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETS63849.1 - 0.00042 20.5 0.0 0.00068 19.8 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETS63849.1 - 0.018 15.2 0.1 0.031 14.5 0.1 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETS63849.1 - 0.024 14.7 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETS63849.1 - 0.12 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain 5_nucleotid_C PF02872.18 ETS63850.1 - 0.0078 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Sde2_N_Ubi PF13019.6 ETS63851.1 - 1.2e-35 122.7 0.9 1.2e-35 122.7 0.9 1.7 2 0 0 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain Lactamase_B_2 PF12706.7 ETS63852.1 - 0.002 17.7 2.2 0.021 14.3 0.8 2.8 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ETS63852.1 - 0.035 13.5 0.0 0.085 12.3 0.0 1.6 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily domain DRMBL PF07522.14 ETS63852.1 - 0.049 13.8 0.0 0.51 10.5 0.0 2.3 2 0 0 2 2 2 0 DNA repair metallo-beta-lactamase zf-RING_2 PF13639.6 ETS63853.1 - 6.5e-07 29.6 7.0 1.3e-06 28.6 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETS63853.1 - 0.0011 19.2 5.6 0.0027 17.9 5.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETS63853.1 - 0.0025 17.8 1.6 0.0053 16.8 1.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 ETS63853.1 - 0.0047 17.1 3.1 0.012 15.8 3.1 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain C1_1 PF00130.22 ETS63853.1 - 0.029 14.2 0.8 0.057 13.3 0.8 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 ETS63853.1 - 0.053 13.4 7.6 0.1 12.5 7.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS63853.1 - 0.38 10.7 7.4 0.78 9.6 7.4 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETS63853.1 - 0.48 10.8 5.0 1 9.8 5.0 1.6 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 ETS63853.1 - 0.54 10.4 8.4 0.16 12.2 5.2 1.9 2 0 0 2 2 1 0 RING-variant domain SpoIIIAH PF12685.7 ETS63853.1 - 1.3 8.8 5.2 3.4 7.4 0.2 2.8 2 0 0 2 2 2 0 SpoIIIAH-like protein Zn_ribbon_17 PF17120.5 ETS63853.1 - 1.3 8.7 3.0 2.9 7.6 3.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 ETS63853.1 - 2.2 8.1 5.1 4.4 7.2 5.1 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_9 PF13901.6 ETS63853.1 - 4.6 7.2 5.2 5.2 7.0 3.2 2.1 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon TFIIS_M PF07500.14 ETS63854.1 - 1.9e-24 86.3 2.0 1.9e-24 86.3 2.0 2.0 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 ETS63854.1 - 4.8e-12 45.6 8.1 8.2e-12 44.8 8.1 1.4 1 0 0 1 1 1 1 PHD-finger SPOC PF07744.13 ETS63854.1 - 7.1e-08 32.5 0.0 1.6e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 SPOC domain PHD_2 PF13831.6 ETS63854.1 - 0.0074 15.8 2.9 0.013 15.0 2.9 1.4 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 ETS63854.1 - 2.1 8.0 9.7 0.49 10.0 5.9 1.9 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain Porin_3 PF01459.22 ETS63855.1 - 1.1e-82 277.5 3.2 1.3e-82 277.3 3.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin Fcf1 PF04900.12 ETS63856.1 - 2.7e-36 123.9 1.1 5.3e-36 123.0 1.1 1.5 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 ETS63856.1 - 9.3e-13 48.5 0.0 6.3e-12 45.8 0.0 2.0 2 0 0 2 2 2 1 PIN like domain Imm-NTF2 PF15655.6 ETS63856.1 - 0.17 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 NTF2 fold immunity protein Peptidase_M22 PF00814.25 ETS63858.1 - 9.5e-73 245.2 0.3 1.2e-72 244.8 0.3 1.1 1 0 0 1 1 1 1 Glycoprotease family Exo_endo_phos PF03372.23 ETS63859.1 - 1.4e-11 44.3 0.2 4.5e-11 42.7 0.2 1.8 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 ETS63859.1 - 1.8e-08 34.3 6.6 4.6e-07 29.8 0.3 3.1 2 1 1 3 3 3 2 GRF zinc finger Exo_endo_phos_2 PF14529.6 ETS63859.1 - 0.043 13.6 0.0 1.7 8.5 0.0 2.4 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase SCA7 PF08313.12 ETS63860.1 - 6.2e-30 102.9 0.1 1.3e-29 101.9 0.1 1.6 1 0 0 1 1 1 1 SCA7, zinc-binding domain BRF1 PF07741.13 ETS63860.1 - 0.31 11.4 3.4 0.73 10.2 0.3 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain DASH_Dad2 PF08654.10 ETS63861.1 - 1.5e-25 89.5 0.0 1.9e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 DUF3348 PF11828.8 ETS63861.1 - 0.0073 16.0 0.0 0.0089 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3348) ATP-synt_ab PF00006.25 ETS63862.1 - 5.6e-106 353.0 0.0 7.8e-106 352.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 ETS63862.1 - 4.9e-43 145.8 0.0 8.8e-43 145.0 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 ETS63862.1 - 1.8e-14 54.0 3.5 4e-14 52.9 3.5 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain VAPB_antitox PF02697.14 ETS63862.1 - 0.069 13.9 0.1 2.5 9.0 0.1 3.0 3 0 0 3 3 3 0 Putative antitoxin AAA PF00004.29 ETS63864.1 - 7.3e-42 142.9 0.0 2.4e-41 141.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS63864.1 - 1.3e-06 28.1 0.1 2.8e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ETS63864.1 - 3e-05 24.0 0.1 0.00011 22.2 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETS63864.1 - 9.7e-05 22.7 0.0 0.0057 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ETS63864.1 - 0.00013 22.4 0.3 0.0027 18.1 0.0 2.4 2 1 1 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 ETS63864.1 - 0.00023 21.3 0.0 0.00078 19.6 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ETS63864.1 - 0.00083 18.6 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 ETS63864.1 - 0.0035 17.1 0.0 0.0073 16.1 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ETS63864.1 - 0.013 15.0 0.0 0.031 13.8 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 ETS63864.1 - 0.017 15.4 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETS63864.1 - 0.025 14.8 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETS63864.1 - 0.025 14.3 0.1 0.14 11.9 0.0 2.3 2 1 0 2 2 2 0 AAA domain AAA_3 PF07726.11 ETS63864.1 - 0.044 13.6 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ETS63864.1 - 0.053 13.9 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 ETS63864.1 - 0.055 13.4 0.0 7.2 6.4 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 ETS63864.1 - 0.058 12.6 0.0 0.11 11.7 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 ETS63864.1 - 0.07 12.5 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ETS63864.1 - 0.072 13.6 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ETS63864.1 - 0.089 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 ETS63864.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 ETS63864.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ETS63864.1 - 0.15 11.8 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF4187 PF13821.6 ETS63865.1 - 6.8e-20 70.6 5.7 1.5e-19 69.5 5.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 ETS63865.1 - 9.5e-06 25.4 1.2 2.2e-05 24.2 1.2 1.6 1 0 0 1 1 1 1 G-patch domain TMA7 PF09072.10 ETS63865.1 - 0.9 10.4 0.1 0.9 10.4 0.1 3.2 5 0 0 5 5 5 0 Translation machinery associated TMA7 CDP-OH_P_transf PF01066.21 ETS63866.1 - 1.2e-12 48.4 0.7 1.2e-12 48.4 0.7 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ORC_WH_C PF18137.1 ETS63867.1 - 8e-28 97.3 0.4 2.9e-27 95.4 0.0 2.2 2 0 0 2 2 2 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 ETS63867.1 - 1.2e-11 44.3 0.0 0.0002 20.6 0.0 3.2 3 0 0 3 3 3 2 Origin recognition complex (ORC) subunit 3 N-terminus DNA_pol_phi PF04931.13 ETS63868.1 - 6.6 4.7 7.2 10 4.1 7.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF2205 PF10224.9 ETS63869.1 - 1.4e-09 37.8 0.4 2.3e-09 37.1 0.4 1.2 1 0 0 1 1 1 1 Short coiled-coil protein CBM_21 PF03370.13 ETS63873.1 - 6.1e-29 100.5 0.1 1e-28 99.8 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ETS63873.1 - 7e-07 29.7 0.4 1.6e-06 28.6 0.4 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Serglycin PF04360.12 ETS63873.1 - 1.1 9.2 3.9 2.8 7.9 3.9 1.6 1 0 0 1 1 1 0 Serglycin V_ATPase_I PF01496.19 ETS63875.1 - 0 1013.5 0.0 0 1013.3 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family VCBS PF13517.6 ETS63876.1 - 1.1e-19 70.7 17.2 2.9e-07 31.0 1.8 6.1 4 1 2 6 6 6 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ETS63876.1 - 8.2e-08 32.2 18.0 0.00042 20.4 0.5 6.2 6 0 0 6 6 6 3 FG-GAP repeat RNase_H2-Ydr279 PF09468.10 ETS63876.1 - 8.7e-08 32.5 0.0 1.4e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 ETS63876.1 - 1.8e-06 28.1 0.0 5.2e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain TcdB_toxin_midN PF12256.8 ETS63876.1 - 0.057 12.8 1.4 16 4.8 0.0 3.9 5 0 0 5 5 5 0 Insecticide toxin TcdB middle/N-terminal region Dockerin_1 PF00404.18 ETS63876.1 - 0.25 11.5 1.7 11 6.3 0.1 3.7 3 1 0 3 3 3 0 Dockerin type I domain 2Fe-2S_thioredx PF01257.19 ETS63877.1 - 1.4e-59 200.1 0.1 1.8e-59 199.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin DUF1636 PF07845.11 ETS63877.1 - 0.12 12.8 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1636) HTH_30 PF13556.6 ETS63877.1 - 0.16 11.8 0.1 0.34 10.7 0.1 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain Mitofilin PF09731.9 ETS63878.1 - 8.2e-168 560.1 24.3 9.3e-168 559.9 24.3 1.0 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Cas_DxTHG PF09455.10 ETS63878.1 - 1.6 8.2 14.8 0.072 12.7 8.6 1.8 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family Exonuc_VII_L PF02601.15 ETS63878.1 - 2.5 7.6 18.0 0.58 9.7 8.9 2.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF2242 PF10001.9 ETS63879.1 - 1.3 9.2 4.2 2 8.6 2.5 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2242) EthD PF07110.11 ETS63880.1 - 6.3e-09 36.9 0.1 1.2e-07 32.8 0.0 2.1 2 0 0 2 2 2 1 EthD domain DUF4129 PF13559.6 ETS63880.1 - 0.019 15.2 0.1 0.1 12.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4129) Cdc13_OB4_dimer PF18233.1 ETS63880.1 - 0.051 13.7 0.0 0.094 12.9 0.0 1.5 1 0 0 1 1 1 0 Cdc13 OB4 dimerization domain Peptidase_M20 PF01546.28 ETS63881.1 - 6.3e-28 97.9 0.0 1.2e-27 96.9 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETS63881.1 - 3.8e-14 52.5 0.0 1e-13 51.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase dimerisation domain Abhydrolase_3 PF07859.13 ETS63882.1 - 9.3e-33 113.9 0.0 5e-32 111.5 0.0 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 ETS63882.1 - 0.00094 18.9 0.0 0.061 12.9 0.0 2.3 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETS63882.1 - 0.0026 17.2 0.0 0.063 12.7 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETS63882.1 - 0.014 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase BAAT_C PF08840.11 ETS63882.1 - 0.033 14.1 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal COesterase PF00135.28 ETS63882.1 - 0.06 12.2 0.0 0.19 10.6 0.0 1.7 1 1 0 1 1 1 0 Carboxylesterase family Esterase PF00756.20 ETS63882.1 - 0.11 12.1 0.4 11 5.6 0.3 3.4 2 1 0 2 2 2 0 Putative esterase Sigma70_r4 PF04545.16 ETS63882.1 - 0.12 12.0 0.2 0.26 10.8 0.2 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 Chlorophyllase2 PF12740.7 ETS63882.1 - 0.14 11.1 0.0 0.35 9.7 0.0 1.6 2 0 0 2 2 2 0 Chlorophyllase enzyme DLH PF01738.18 ETS63882.1 - 0.14 11.7 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family Polysacc_deac_1 PF01522.21 ETS63883.1 - 1.1e-22 80.2 0.0 2.3e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Nup160 PF11715.8 ETS63884.1 - 3.6e-132 441.8 0.0 5.5e-132 441.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 SO_alpha_A3 PF17806.1 ETS63884.1 - 0.0091 16.3 0.4 1.4 9.3 0.0 3.2 3 0 0 3 3 3 1 Sarcosine oxidase A3 domain ATP-sulfurylase PF01747.17 ETS63884.1 - 0.019 14.5 0.0 0.047 13.2 0.0 1.7 1 0 0 1 1 1 0 ATP-sulfurylase TPR_19 PF14559.6 ETS63884.1 - 1.1 9.8 7.4 2 9.0 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat FAD_binding_3 PF01494.19 ETS63885.1 - 9.8e-57 192.8 0.0 1.2e-55 189.2 0.0 2.4 1 1 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 ETS63885.1 - 5.6e-20 72.0 0.0 9e-19 68.1 0.0 2.2 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain NAD_binding_8 PF13450.6 ETS63885.1 - 1.5e-05 25.1 0.0 4.6e-05 23.6 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ETS63885.1 - 9.6e-05 21.3 0.0 0.00015 20.6 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 ETS63885.1 - 0.00011 21.9 0.0 0.00022 20.9 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS63885.1 - 0.00014 21.2 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS63885.1 - 0.0017 17.5 0.1 0.0037 16.4 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETS63885.1 - 0.0022 17.3 0.0 0.0037 16.6 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 ETS63885.1 - 0.0023 17.2 0.1 0.0088 15.3 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS63885.1 - 0.0059 15.7 0.1 0.0084 15.2 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 ETS63885.1 - 0.021 15.4 0.0 0.042 14.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS63885.1 - 0.027 14.5 0.0 0.056 13.4 0.0 1.6 1 0 0 1 1 1 0 FAD-NAD(P)-binding DUF1580 PF07618.11 ETS63885.1 - 0.087 12.5 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) ApbA PF02558.16 ETS63885.1 - 0.13 11.9 0.0 0.4 10.3 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 ETS63885.1 - 0.15 10.9 0.0 0.22 10.3 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase UDPG_MGDP_dh_N PF03721.14 ETS63885.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Adaptin_binding PF10199.9 ETS63886.1 - 0.12 13.0 0.0 0.12 13.0 0.0 2.8 3 2 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 MitMem_reg PF13012.6 ETS63887.1 - 2.7e-23 82.5 2.2 6.8e-23 81.2 2.2 1.7 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ETS63887.1 - 2.9e-17 62.7 0.0 9.5e-16 57.8 0.0 2.3 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CENP-W PF15510.6 ETS63888.1 - 2.2e-06 27.8 0.3 2.7e-06 27.5 0.3 1.3 1 1 0 1 1 1 1 CENP-W protein PI3K_P85_iSH2 PF16454.5 ETS63889.1 - 0.21 11.2 1.3 0.42 10.2 1.3 1.4 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain TPR_MLP1_2 PF07926.12 ETS63889.1 - 0.34 11.0 3.6 0.84 9.7 3.6 1.7 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 ETS63889.1 - 1.4 9.1 6.4 1.4 9.0 4.6 2.0 1 1 0 1 1 1 0 TolA binding protein trimerisation FAD_binding_6 PF00970.24 ETS63890.1 - 3.4e-34 117.1 0.1 5.6e-34 116.4 0.1 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ETS63890.1 - 7.8e-31 107.0 0.0 1.2e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETS63890.1 - 6.2e-09 36.2 0.0 5.2e-07 29.9 0.0 2.2 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ETS63890.1 - 0.03 14.5 0.0 0.067 13.4 0.0 1.6 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Senescence PF06911.12 ETS63891.1 - 1.7e-48 165.4 7.4 1.7e-48 165.4 7.4 2.1 2 0 0 2 2 2 1 Senescence-associated protein RNase_H PF00075.24 ETS63893.1 - 0.00016 21.9 0.0 0.00037 20.7 0.0 1.7 1 0 0 1 1 1 1 RNase H Epimerase PF01370.21 ETS63894.1 - 0.0029 17.1 0.0 0.0042 16.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TPR_1 PF00515.28 ETS63895.1 - 2.4e-26 90.4 10.9 1.8e-05 24.4 0.0 8.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETS63895.1 - 3.2e-23 79.9 6.0 2.3e-06 27.4 0.0 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat ANAPC8 PF04049.13 ETS63895.1 - 7.4e-20 71.4 0.1 1.3e-11 44.7 0.0 2.6 2 0 0 2 2 2 2 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 ETS63895.1 - 1.4e-19 68.6 17.6 0.00088 19.2 0.1 9.0 10 0 0 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETS63895.1 - 7.4e-12 45.0 17.2 0.00038 21.0 0.1 9.1 5 2 5 10 10 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS63895.1 - 7.7e-11 42.1 11.6 0.0059 16.8 0.0 4.4 4 1 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ETS63895.1 - 1.7e-10 41.0 19.9 8.1e-05 22.8 0.2 7.6 6 2 1 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS63895.1 - 7.8e-10 38.4 1.2 0.091 13.2 0.2 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS63895.1 - 7.1e-09 36.2 1.3 7.1e-09 36.2 1.3 6.5 7 1 2 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETS63895.1 - 1.6e-08 34.0 12.4 0.71 10.0 0.0 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETS63895.1 - 2.2e-08 34.1 17.0 0.0011 19.1 0.1 6.4 5 1 2 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS63895.1 - 3.1e-08 34.0 6.3 0.069 13.7 0.1 6.2 6 1 2 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETS63895.1 - 1.3e-07 31.1 5.0 1.2e-05 24.9 1.2 3.2 3 0 0 3 3 3 2 TPR repeat TPR_15 PF13429.6 ETS63895.1 - 3.4e-07 29.8 3.1 0.1 11.8 0.0 4.6 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETS63895.1 - 3.6e-05 24.1 12.8 0.46 11.2 0.3 7.8 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETS63895.1 - 0.021 14.7 16.0 27 4.8 0.1 7.1 8 0 0 8 8 7 0 Tetratricopeptide repeat ST7 PF04184.12 ETS63895.1 - 0.089 11.3 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 ST7 protein Ribosomal_S6e PF01092.19 ETS63896.1 - 1.2e-55 186.8 0.4 3.5e-55 185.3 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e Ribosomal_L27A PF00828.19 ETS63896.1 - 0.21 12.3 3.3 0.3 11.8 3.3 1.3 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_S13_N PF08069.12 ETS63897.1 - 3.9e-27 94.1 0.8 1.5e-26 92.2 0.1 2.3 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 ETS63897.1 - 6.5e-14 51.9 0.4 1e-13 51.2 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 ETS63897.1 - 0.015 15.2 0.1 0.04 13.8 0.0 1.7 2 0 0 2 2 2 0 'Paired box' domain HTH_32 PF13565.6 ETS63897.1 - 0.02 15.5 0.3 0.058 14.0 0.1 2.0 1 1 0 1 1 1 0 Homeodomain-like domain Arrestin_N PF00339.29 ETS63898.1 - 0.0076 16.3 0.0 0.48 10.5 0.0 2.6 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain LRR_4 PF12799.7 ETS63899.1 - 3e-05 24.3 14.7 0.039 14.4 0.2 6.8 6 2 1 8 8 8 4 Leucine Rich repeats (2 copies) Ysc84 PF04366.12 ETS63900.1 - 2.7e-40 137.1 0.0 5.8e-40 136.0 0.0 1.6 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ETS63900.1 - 5.9e-17 61.0 0.1 1.2e-16 60.0 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETS63900.1 - 8.6e-14 51.1 0.1 1.6e-13 50.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETS63900.1 - 3.6e-10 39.4 0.0 8.2e-10 38.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Glyco_hydro_9 PF00759.19 ETS63901.1 - 5.1e-106 355.5 17.7 6.1e-106 355.3 17.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 VSP PF03302.13 ETS63901.1 - 0.0019 17.1 0.7 0.004 16.1 0.3 1.6 2 0 0 2 2 2 1 Giardia variant-specific surface protein Arf PF00025.21 ETS63902.1 - 1e-66 223.7 0.0 1.2e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETS63902.1 - 5.5e-15 55.4 1.0 2.1e-10 40.3 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ETS63902.1 - 8.5e-12 45.3 0.0 1.2e-11 44.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETS63902.1 - 5.2e-11 42.3 0.0 6.9e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETS63902.1 - 2.2e-09 37.0 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 ETS63902.1 - 6.9e-08 32.3 0.0 7.7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ETS63902.1 - 7.4e-08 32.5 0.0 1.6e-07 31.4 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETS63902.1 - 0.005 16.4 0.0 0.076 12.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ETS63902.1 - 0.0059 16.2 0.1 0.016 14.7 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MTBP_N PF14918.6 ETS63902.1 - 0.045 13.2 0.1 0.065 12.7 0.1 1.2 1 0 0 1 1 1 0 MDM2-binding CLU_N PF15044.6 ETS63902.1 - 0.065 13.6 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial function, CLU-N-term XS PF03468.14 ETS63902.1 - 0.076 13.3 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 XS domain TsaE PF02367.17 ETS63902.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIG-U PF06728.13 ETS63903.1 - 6.8e-88 295.3 20.7 1.6e-86 290.8 20.7 2.3 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 ETS63903.1 - 1.9 8.1 8.3 4.7 6.8 8.3 1.6 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain MAT1 PF06391.13 ETS63904.1 - 1.7e-44 152.1 18.8 2.2e-44 151.8 18.8 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 ETS63904.1 - 4.8e-21 74.4 7.4 7.3e-21 73.8 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETS63904.1 - 0.00011 21.9 7.7 0.00042 20.1 7.9 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS63904.1 - 0.00031 20.5 9.6 0.0017 18.2 10.0 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS63904.1 - 0.00064 19.6 6.9 0.0021 18.0 7.2 1.7 1 1 1 2 2 2 1 zinc-RING finger domain Rrn6 PF10214.9 ETS63904.1 - 0.00095 17.8 4.3 0.0011 17.6 4.3 1.1 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor zf-RING_2 PF13639.6 ETS63904.1 - 0.0012 19.1 6.1 0.0022 18.3 6.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 ETS63904.1 - 0.0023 17.7 5.9 0.025 14.4 1.9 2.3 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-C3HC4_2 PF13923.6 ETS63904.1 - 0.0075 16.1 11.4 0.14 12.0 12.3 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 ETS63904.1 - 0.074 13.1 5.8 0.23 11.5 5.8 1.8 1 1 0 1 1 1 0 Double zinc ribbon Prok-RING_4 PF14447.6 ETS63904.1 - 0.084 12.7 10.5 0.53 10.2 10.3 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ETS63904.1 - 0.23 11.5 6.9 0.46 10.6 6.9 1.5 1 0 0 1 1 1 0 RING-type zinc-finger FYDLN_acid PF09538.10 ETS63904.1 - 0.25 12.0 0.2 0.25 12.0 0.2 3.4 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) DNA_ligase_ZBD PF03119.16 ETS63904.1 - 0.27 11.3 1.9 1.1 9.4 0.1 2.5 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Zn-ribbon_8 PF09723.10 ETS63904.1 - 0.31 11.2 7.2 8.2 6.6 3.5 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 ETS63904.1 - 0.52 9.8 5.2 4.3 6.9 0.8 2.5 2 0 0 2 2 2 0 zinc-ribbon domain zf_UBZ PF18439.1 ETS63904.1 - 1.4 8.5 4.0 1.1 8.9 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_2 PF13240.6 ETS63904.1 - 1.6 8.6 5.7 1.1 9.0 1.4 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-UDP PF14569.6 ETS63904.1 - 4.4 7.5 7.7 15 5.8 0.5 2.4 1 1 1 2 2 2 0 Zinc-binding RING-finger RR_TM4-6 PF06459.12 ETS63904.1 - 5.1 6.8 13.1 7.2 6.4 13.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3797 PF12677.7 ETS63904.1 - 5.4 7.0 7.2 2.7 7.9 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) PTPRCAP PF15713.5 ETS63904.1 - 9.5 6.5 20.3 17 5.7 19.8 1.5 1 1 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated AMPK1_CBM PF16561.5 ETS63907.1 - 2.3e-29 101.4 0.0 4.2e-29 100.6 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 ETS63907.1 - 1.6e-28 98.8 0.6 1.6e-28 98.8 0.6 2.3 2 0 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain Torus PF16131.5 ETS63908.1 - 1.8e-07 31.8 0.0 3.8e-07 30.8 0.0 1.6 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 ETS63908.1 - 1.9e-06 27.7 2.7 4.4e-06 26.6 2.7 1.7 1 0 0 1 1 1 1 Zinc finger domain RRM_1 PF00076.22 ETS63908.1 - 3.7e-06 26.6 0.0 7.4e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 ETS63908.1 - 0.0011 18.8 2.1 0.0011 18.8 2.1 2.4 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETS63908.1 - 0.0018 18.1 3.9 0.0048 16.7 3.9 1.8 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ETS63908.1 - 0.034 14.6 2.7 0.093 13.2 2.7 1.8 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger RRM_occluded PF16842.5 ETS63908.1 - 0.078 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif FYVE PF01363.21 ETS63908.1 - 1.2 9.4 5.6 13 6.1 5.6 2.6 1 1 0 1 1 1 0 FYVE zinc finger RNase_T PF00929.24 ETS63909.1 - 2.6e-11 44.3 0.0 1.3e-08 35.6 0.0 2.4 2 0 0 2 2 2 2 Exonuclease SAP PF02037.27 ETS63909.1 - 2.9e-09 36.5 4.0 3.4e-09 36.3 2.6 1.9 2 0 0 2 2 2 1 SAP domain HeH PF12949.7 ETS63909.1 - 0.018 14.8 0.1 0.042 13.6 0.1 1.6 1 0 0 1 1 1 0 HeH/LEM domain THDPS_M PF14789.6 ETS63909.1 - 0.095 12.8 0.1 0.38 10.9 0.0 2.1 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase middle NDUF_C2 PF06374.11 ETS63910.1 - 0.032 14.4 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) Complex1_LYR PF05347.15 ETS63911.1 - 3.4e-06 27.0 0.1 8.8e-06 25.7 0.1 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Ribosomal_L31 PF01197.18 ETS63911.1 - 0.0019 18.4 0.0 0.0037 17.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L31 DUF5486 PF17588.2 ETS63911.1 - 0.16 11.9 1.7 1.1 9.2 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5486) GREB1 PF15782.5 ETS63911.1 - 0.22 8.6 5.6 0.27 8.3 5.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer E1_FCCH PF16190.5 ETS63912.1 - 0.0054 16.9 0.0 0.025 14.8 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 FCCH domain SlyX PF04102.12 ETS63912.1 - 0.0055 17.3 4.1 0.015 15.9 0.0 3.0 3 1 0 3 3 3 1 SlyX DUF3450 PF11932.8 ETS63912.1 - 0.083 12.2 1.5 40 3.4 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) FliJ PF02050.16 ETS63912.1 - 0.92 9.7 5.4 6 7.1 0.1 2.8 3 0 0 3 3 3 0 Flagellar FliJ protein HECT PF00632.25 ETS63913.1 - 6.8e-95 318.1 0.1 9.1e-95 317.7 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 ETS63913.1 - 2.2e-34 117.2 18.4 3.7e-12 46.1 2.6 3.8 3 0 0 3 3 3 3 WW domain C2 PF00168.30 ETS63913.1 - 2e-20 73.0 0.1 5.7e-20 71.5 0.1 1.8 1 0 0 1 1 1 1 C2 domain Nuc_sug_transp PF04142.15 ETS63914.1 - 6.7e-08 32.1 0.2 6.7e-08 32.1 0.2 1.5 2 0 0 2 2 2 1 Nucleotide-sugar transporter UAA PF08449.11 ETS63914.1 - 1.5e-06 27.6 8.8 1.5e-06 27.6 8.8 1.5 2 0 0 2 2 2 1 UAA transporter family TPT PF03151.16 ETS63914.1 - 1.2e-05 24.9 1.1 1.2e-05 24.9 1.1 2.1 2 0 0 2 2 2 1 Triose-phosphate Transporter family EamA PF00892.20 ETS63914.1 - 3.2e-05 24.1 25.4 0.00085 19.5 4.5 3.1 3 1 0 3 3 3 2 EamA-like transporter family CitMHS PF03600.16 ETS63914.1 - 7.6 5.6 10.4 6.2 5.9 8.6 1.7 1 1 0 1 1 1 0 Citrate transporter Hist_deacetyl PF00850.19 ETS63915.1 - 1.6e-81 274.1 0.0 2.2e-81 273.7 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Adaptin_N PF01602.20 ETS63916.1 - 3.5e-150 501.0 6.2 4.2e-150 500.8 6.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 ETS63916.1 - 3.6e-23 82.0 0.6 6.7e-23 81.1 0.6 1.5 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ETS63916.1 - 1.6e-09 38.0 7.0 1.8e-06 28.1 0.7 3.5 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETS63916.1 - 9.7e-06 25.9 3.1 1.9 9.0 0.0 6.3 6 3 2 8 8 8 2 HEAT repeats Peptidase_M73 PF12389.8 ETS63916.1 - 0.075 12.9 0.2 0.2 11.5 0.1 1.7 2 0 0 2 2 2 0 Camelysin metallo-endopeptidase ZIP4_domain PF18292.1 ETS63916.1 - 0.13 12.2 0.0 0.69 9.8 0.0 2.1 2 0 0 2 2 2 0 Zinc transporter ZIP4 domain DUF5578 PF17741.1 ETS63916.1 - 0.19 11.1 1.4 3.1 7.1 0.1 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5578) V-ATPase_H_C PF11698.8 ETS63916.1 - 0.82 9.8 2.6 24 5.1 0.0 3.5 2 1 1 3 3 3 0 V-ATPase subunit H TIP120 PF08623.10 ETS63916.1 - 0.83 9.4 6.6 14 5.4 0.1 4.4 3 2 1 4 4 4 0 TATA-binding protein interacting (TIP20) RINGv PF12906.7 ETS63917.1 - 1.1e-10 41.4 3.8 2e-10 40.6 3.8 1.4 1 0 0 1 1 1 1 RING-variant domain Cytochrom_C552 PF02335.15 ETS63917.1 - 0.091 11.7 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c552 Uricase PF01014.18 ETS63920.1 - 6.8e-61 204.3 0.0 6.4e-33 113.8 0.1 2.2 2 0 0 2 2 2 2 Uricase GLTP PF08718.11 ETS63921.1 - 3.3e-49 167.0 0.0 4.5e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) WD40 PF00400.32 ETS63922.1 - 3.4e-08 34.0 1.4 0.08 13.9 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ABC1 PF03109.16 ETS63923.1 - 2.4e-20 72.9 0.0 9.7e-13 48.3 0.0 2.5 2 0 0 2 2 2 2 ABC1 family Phenyl_P_gamma PF09662.10 ETS63923.1 - 0.19 11.9 0.1 0.72 10.1 0.0 1.9 2 0 0 2 2 2 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) AdoMet_MTase PF07757.13 ETS63924.1 - 6e-35 120.0 0.0 1e-34 119.2 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 ETS63924.1 - 0.00086 19.3 0.3 0.019 15.0 0.3 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS63924.1 - 0.015 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ETS63924.1 - 0.029 15.0 0.0 0.068 13.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ETS63924.1 - 0.052 14.2 0.0 0.25 12.0 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 ETS63924.1 - 0.096 12.5 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 ETS63924.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MFS_1 PF07690.16 ETS63925.1 - 1.4e-42 145.9 57.8 8e-39 133.6 38.1 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS63925.1 - 4.2e-13 49.0 7.1 4.2e-13 49.0 7.1 2.8 2 1 0 3 3 3 2 Sugar (and other) transporter ANAPC10 PF03256.16 ETS63926.1 - 7.1e-49 166.0 0.0 1.1e-48 165.4 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) zf-Tim10_DDP PF02953.15 ETS63927.1 - 1.2e-24 85.7 0.8 1.6e-24 85.3 0.8 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Acyltransferase PF01553.21 ETS63928.1 - 1e-21 77.0 0.0 1.5e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase NAD_binding_1 PF00175.21 ETS63929.1 - 4.1e-08 33.8 0.0 0.0012 19.5 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETS63929.1 - 0.02 15.0 0.1 0.27 11.3 0.1 2.2 1 1 0 1 1 1 0 Ferric reductase NAD binding domain DKCLD PF08068.12 ETS63931.1 - 4.2e-33 113.2 0.1 1e-31 108.7 0.2 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 ETS63931.1 - 9.6e-24 84.4 0.4 1.1e-20 74.6 0.4 3.4 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ETS63931.1 - 7.3e-23 80.5 0.6 1.4e-22 79.6 0.6 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 ETS63931.1 - 1.1e-20 73.3 1.4 2.3e-20 72.3 1.4 1.6 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 ETS63931.1 - 0.0023 18.2 0.0 0.0058 16.9 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain RNA_polI_A34 PF08208.11 ETS63931.1 - 0.66 10.0 27.0 1.1 9.4 27.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SOBP PF15279.6 ETS63931.1 - 4.9 7.7 7.3 6.9 7.2 7.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Ribosomal_L22e PF01776.17 ETS63932.1 - 9.4e-47 157.9 0.3 1.1e-46 157.7 0.3 1.1 1 0 0 1 1 1 1 Ribosomal L22e protein family SSB PF00436.25 ETS63932.1 - 0.082 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Single-strand binding protein family WD40 PF00400.32 ETS63933.1 - 4.2e-17 62.2 16.2 0.0006 20.6 0.2 7.5 6 1 1 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 ETS63933.1 - 0.051 12.2 0.0 0.29 9.7 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 DUF4278 PF14105.6 ETS63933.1 - 0.056 13.9 0.5 0.13 12.8 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) Peptidase_M28 PF04389.17 ETS63934.1 - 7e-26 91.2 0.2 9.8e-26 90.7 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ETS63934.1 - 1.2e-08 34.9 0.1 2.5e-08 33.9 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 LTV PF04180.14 ETS63935.1 - 3.7e-97 326.5 5.6 3.7e-97 326.5 5.6 2.8 3 0 0 3 3 3 2 Low temperature viability protein Tho2 PF11262.8 ETS63935.1 - 1.9 7.7 5.7 3.3 6.8 5.7 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 EXOSC1 PF10447.9 ETS63936.1 - 1e-22 80.8 0.1 7e-22 78.1 0.1 2.2 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 ETS63936.1 - 0.0036 17.1 0.7 0.03 14.1 0.7 2.5 1 1 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region Pkinase PF00069.25 ETS63937.1 - 1.4e-45 155.7 0.0 3.5e-45 154.4 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63937.1 - 5.4e-25 88.2 0.0 8.4e-25 87.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETS63937.1 - 0.021 14.8 0.2 0.062 13.2 0.2 1.8 1 0 0 1 1 1 0 Phosphotransferase enzyme family CCDC24 PF15669.5 ETS63937.1 - 2.9 7.7 5.9 1.9 8.3 0.3 2.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family Glyco_hydro_62 PF03664.13 ETS63938.1 - 7.8e-146 484.6 8.1 9e-146 484.3 8.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 62 GPI-anchored PF10342.9 ETS63939.1 - 4.6e-08 33.7 0.5 4.6e-08 33.7 0.5 2.0 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Pescadillo_N PF06732.11 ETS63940.1 - 1.5e-118 395.3 0.1 1.5e-118 395.3 0.1 1.7 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 ETS63940.1 - 6.9e-05 23.2 0.0 0.00025 21.4 0.0 2.0 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Sterol_MT_C PF08498.10 ETS63940.1 - 0.18 12.2 0.0 0.42 11.0 0.0 1.5 1 0 0 1 1 1 0 Sterol methyltransferase C-terminal Acyl-CoA_dh_1 PF00441.24 ETS63941.1 - 9.5e-34 116.8 5.6 2e-33 115.7 5.6 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS63941.1 - 1.2e-19 70.2 0.0 2.6e-19 69.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ETS63941.1 - 1.9e-17 64.0 0.5 8.7e-17 61.8 0.0 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ETS63941.1 - 2.5e-12 47.2 6.7 2.5e-12 47.2 6.7 2.7 3 0 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Glyco_hydro_20 PF00728.22 ETS63942.1 - 2.4e-83 280.5 0.0 3.3e-83 280.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ETS63942.1 - 3.3e-17 63.4 0.0 8.1e-17 62.2 0.0 1.7 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ETS63942.1 - 8.3e-06 26.6 0.0 0.00017 22.4 0.0 2.3 2 0 0 2 2 2 1 Glycosyl hydrolase family 20, domain 2 UCH PF00443.29 ETS63943.1 - 6.9e-29 101.1 0.0 9.8e-29 100.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ETS63943.1 - 3.2e-11 43.4 0.2 7e-11 42.3 0.2 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ETS63943.1 - 3.2e-05 23.7 0.0 0.00041 20.1 0.0 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Period_C PF12114.8 ETS63943.1 - 0.061 12.9 1.9 0.14 11.8 1.9 1.5 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Herpes_capsid PF06112.11 ETS63943.1 - 0.16 12.0 2.7 0.38 10.8 2.7 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein zf-UBP_var PF17807.1 ETS63943.1 - 0.24 11.2 0.3 0.57 10.0 0.3 1.6 1 0 0 1 1 1 0 Variant UBP zinc finger ODC_AZ PF02100.17 ETS63944.1 - 6.6e-13 48.6 0.0 1.2e-12 47.8 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme SUIM_assoc PF16619.5 ETS63944.1 - 0.9 9.7 7.1 3.7 7.7 7.1 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Es2 PF09751.9 ETS63945.1 - 4e-104 349.8 10.4 4e-104 349.8 10.4 1.5 2 0 0 2 2 2 1 Nuclear protein Es2 ADH_zinc_N PF00107.26 ETS63946.1 - 3e-12 46.6 0.5 1.3e-11 44.6 0.1 2.3 3 0 0 3 3 3 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS63946.1 - 2e-10 40.5 0.0 4.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain WD40 PF00400.32 ETS63948.1 - 1.3e-38 130.3 18.4 6.8e-07 29.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS63948.1 - 4.7e-16 58.9 0.0 0.00092 19.5 0.1 5.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETS63948.1 - 0.0011 18.4 0.0 3 7.1 0.0 3.4 2 1 1 4 4 4 2 WD40-like domain Oberon_cc PF16312.5 ETS63948.1 - 0.43 10.5 1.8 0.75 9.7 1.8 1.3 1 0 0 1 1 1 0 Coiled-coil region of Oberon 4HBT_2 PF13279.6 ETS63949.1 - 6.7e-12 46.0 0.2 1.3e-11 45.1 0.2 1.4 1 1 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 ETS63949.1 - 0.00037 20.8 0.0 0.00082 19.7 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 ETS63949.1 - 0.0012 18.2 0.1 0.0039 16.5 0.1 1.7 2 0 0 2 2 2 1 Acyl-ACP thioesterase PPR_2 PF13041.6 ETS63950.1 - 3.2e-06 27.2 0.0 1 9.6 0.0 6.6 7 0 0 7 7 7 1 PPR repeat family PPR PF01535.20 ETS63950.1 - 0.00011 22.2 3.0 2.9 8.4 0.0 5.9 7 0 0 7 7 7 2 PPR repeat AbiEi_3 PF11459.8 ETS63950.1 - 0.087 12.5 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system 7TMR-HDED PF07697.11 ETS63950.1 - 0.098 12.8 0.3 0.53 10.4 0.1 2.1 2 0 0 2 2 2 0 7TM-HD extracellular TPR_14 PF13428.6 ETS63950.1 - 1.5 9.8 9.7 72 4.6 0.2 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat GATA PF00320.27 ETS63951.1 - 1.6e-13 50.0 5.4 2.9e-13 49.1 5.4 1.4 1 0 0 1 1 1 1 GATA zinc finger Hepar_II_III PF07940.13 ETS63952.1 - 2.9e-09 36.9 0.5 6.9e-09 35.7 0.5 1.6 1 0 0 1 1 1 1 Heparinase II/III-like protein Arc_PepC_II PF06847.11 ETS63952.1 - 0.1 13.1 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II Pyr_redox_2 PF07992.14 ETS63953.1 - 5e-12 45.6 0.0 2.2e-06 27.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETS63953.1 - 1.8e-11 43.8 0.0 6.5e-08 32.1 0.0 2.8 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ETS63953.1 - 3.6e-10 39.9 0.0 8.6e-10 38.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FMO-like PF00743.19 ETS63953.1 - 5.6e-10 38.3 1.0 7e-09 34.6 1.0 2.3 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ETS63953.1 - 1.2e-09 37.9 0.3 7.5e-06 25.4 0.1 3.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS63953.1 - 7.6e-08 32.3 0.1 2.7e-06 27.2 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ETS63953.1 - 1.5e-05 25.0 0.0 0.027 14.5 0.0 3.0 3 0 0 3 3 3 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.12 ETS63953.1 - 3.6e-05 23.0 0.1 0.09 11.8 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Thi4 PF01946.17 ETS63953.1 - 0.00036 19.9 0.0 0.014 14.7 0.0 2.5 3 0 0 3 3 3 1 Thi4 family Pyr_redox PF00070.27 ETS63953.1 - 0.0079 16.7 0.0 0.21 12.2 0.0 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETS63953.1 - 0.011 14.6 0.0 0.099 11.5 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase GIDA PF01134.22 ETS63953.1 - 0.025 13.7 0.0 2.1 7.3 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Shikimate_DH PF01488.20 ETS63953.1 - 0.035 14.1 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Mqo PF06039.15 ETS63953.1 - 0.21 10.1 0.0 0.58 8.6 0.0 1.7 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) FAD_binding_3 PF01494.19 ETS63953.1 - 0.24 10.6 0.3 12 5.0 0.1 2.7 2 1 0 3 3 3 0 FAD binding domain Tim17 PF02466.19 ETS63954.1 - 1.5e-32 112.3 4.7 2.1e-32 111.8 4.7 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 ETS63954.1 - 0.18 11.9 8.5 0.36 11.0 0.3 2.8 2 1 1 3 3 3 0 LydA holin phage, holin superfamily III Sec5 PF15469.6 ETS63955.1 - 8.3e-55 185.6 0.0 1.8e-54 184.5 0.0 1.6 1 0 0 1 1 1 1 Exocyst complex component Sec5 CENP-H PF05837.12 ETS63955.1 - 0.12 12.8 4.1 1.3 9.5 0.0 3.4 3 1 0 3 3 3 0 Centromere protein H (CENP-H) PA28_beta PF02252.18 ETS63956.1 - 5.1e-48 162.4 0.1 7.3e-48 161.9 0.1 1.2 1 0 0 1 1 1 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETS63956.1 - 0.0016 18.4 0.1 0.0039 17.2 0.1 1.8 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit ABC_membrane PF00664.23 ETS63957.1 - 1.7e-63 214.9 27.5 5.4e-33 114.8 7.7 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS63957.1 - 1.2e-54 184.6 0.1 4e-30 105.1 0.0 3.6 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 ETS63957.1 - 4.7e-10 39.3 0.3 0.00082 18.9 0.0 4.0 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETS63957.1 - 1.3e-06 28.5 1.0 0.46 10.2 0.1 3.8 4 0 0 4 4 3 2 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 ETS63957.1 - 2.8e-06 27.4 1.0 0.012 15.7 0.2 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 ETS63957.1 - 5.5e-06 26.9 0.1 0.019 15.4 0.0 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ETS63957.1 - 1.2e-05 24.9 1.1 0.14 11.9 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETS63957.1 - 0.00014 21.8 1.6 0.33 10.8 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 ETS63957.1 - 0.0012 19.4 6.2 0.45 11.0 0.1 3.0 3 0 0 3 3 2 2 AAA domain Dynamin_N PF00350.23 ETS63957.1 - 0.002 18.2 4.0 0.54 10.3 0.2 2.8 2 0 0 2 2 2 2 Dynamin family MeaB PF03308.16 ETS63957.1 - 0.012 14.6 0.7 0.56 9.1 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 ETS63957.1 - 0.014 15.7 0.8 13 6.1 0.0 3.3 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ETS63957.1 - 0.017 14.4 0.7 5.5 6.2 0.1 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_15 PF13175.6 ETS63957.1 - 0.024 14.4 0.1 5.7 6.5 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 ETS63957.1 - 0.032 14.0 1.2 1.5 8.5 0.1 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 ETS63957.1 - 0.037 13.7 3.5 2.9 7.6 0.0 3.0 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 ETS63957.1 - 0.038 13.5 0.2 4.8 6.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Roc PF08477.13 ETS63957.1 - 0.038 14.2 0.2 6 7.1 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 ETS63957.1 - 0.046 13.3 1.3 5 6.7 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 ETS63957.1 - 0.049 13.2 1.9 1.5 8.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 ETS63957.1 - 0.058 13.3 0.5 3.7 7.4 0.0 2.5 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 ETS63957.1 - 0.06 12.4 1.7 5.3 6.0 0.0 3.1 3 0 0 3 3 3 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ETS63957.1 - 0.065 12.6 1.1 7.8 5.8 0.0 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family IstB_IS21 PF01695.17 ETS63957.1 - 0.069 12.9 0.8 17 5.0 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein TrwB_AAD_bind PF10412.9 ETS63957.1 - 0.095 11.6 0.3 7.5 5.4 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain DUF815 PF05673.13 ETS63957.1 - 0.098 11.8 0.2 6 5.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) DUF87 PF01935.17 ETS63957.1 - 0.14 12.2 2.4 0.72 9.9 0.5 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain MobB PF03205.14 ETS63957.1 - 0.17 11.8 4.5 24 4.8 0.0 3.9 4 0 0 4 4 4 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 ETS63957.1 - 0.22 11.5 0.3 4.9 7.2 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ETS63957.1 - 0.51 10.5 4.4 23 5.1 0.2 3.5 3 0 0 3 3 3 0 AAA domain NPL4 PF05021.15 ETS63958.1 - 1.6e-108 362.7 0.0 2.3e-108 362.2 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 ETS63958.1 - 2.2e-65 219.2 1.0 3.7e-65 218.5 1.0 1.4 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 ETS63958.1 - 0.0043 17.5 0.0 0.013 16.0 0.0 1.8 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 DUF5572 PF17733.1 ETS63958.1 - 0.089 12.6 0.3 0.23 11.3 0.3 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5572) DEC-1_N PF04625.13 ETS63958.1 - 6.6 5.6 6.9 1.7 7.5 0.6 2.4 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region RRM_1 PF00076.22 ETS63959.1 - 1.4e-10 40.8 0.0 2e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-Tim10_DDP PF02953.15 ETS63960.1 - 3.6e-22 77.8 0.3 4.7e-22 77.4 0.3 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Sugar_tr PF00083.24 ETS63962.1 - 1.8e-106 356.7 10.4 2.2e-106 356.4 10.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS63962.1 - 2.9e-23 82.4 20.8 2.9e-23 82.4 20.8 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETS63962.1 - 0.0022 16.6 4.1 0.0022 16.6 4.1 2.8 2 1 1 3 3 3 2 MFS/sugar transport protein Pkinase PF00069.25 ETS63963.1 - 2.4e-71 240.2 0.0 4.1e-71 239.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS63963.1 - 1.2e-48 165.7 0.0 1.9e-48 165.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS63963.1 - 0.00058 18.7 0.7 0.0029 16.4 0.7 2.0 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETS63963.1 - 0.0018 17.7 0.0 0.0048 16.3 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Aldo_ket_red PF00248.21 ETS63964.1 - 1.4e-56 191.8 0.0 1.6e-56 191.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family PAXNEB PF05625.11 ETS63965.1 - 3e-41 141.8 0.0 3e-39 135.2 0.0 2.9 1 1 0 1 1 1 1 PAXNEB protein CytochromB561_N PF09786.9 ETS63965.1 - 1.6 7.6 3.3 3 6.7 0.7 2.1 2 0 0 2 2 2 0 Cytochrome B561, N terminal Ferritin_2 PF13668.6 ETS63966.1 - 8.3e-42 142.6 2.3 1.5e-41 141.8 2.3 1.4 1 0 0 1 1 1 1 Ferritin-like domain PAP2 PF01569.21 ETS63967.1 - 1e-11 44.7 9.1 9e-11 41.7 8.6 2.2 1 1 0 1 1 1 1 PAP2 superfamily DUF212 PF02681.14 ETS63967.1 - 8.4e-05 22.7 0.9 0.0013 18.9 0.2 2.4 2 0 0 2 2 2 1 Divergent PAP2 family DUF2614 PF11023.8 ETS63967.1 - 0.16 12.0 0.2 0.16 12.0 0.2 2.0 2 1 1 3 3 3 0 Zinc-ribbon containing domain Rep_fac_C PF08542.11 ETS63968.1 - 1.8e-25 89.2 0.0 4.2e-25 88.0 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 ETS63968.1 - 2.1e-12 47.6 0.0 5e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ETS63968.1 - 2.3e-12 47.0 0.0 2.7e-10 40.3 0.1 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 ETS63968.1 - 2.1e-06 28.2 0.1 0.0002 21.8 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ETS63968.1 - 4.9e-06 26.6 0.0 8.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ETS63968.1 - 2.9e-05 23.9 0.0 5.9e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS63968.1 - 7e-05 23.1 0.0 0.07 13.4 0.0 2.3 1 1 1 2 2 2 2 AAA domain Rad17 PF03215.15 ETS63968.1 - 0.00058 19.8 0.0 0.0012 18.8 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain Viral_helicase1 PF01443.18 ETS63968.1 - 0.0009 19.1 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase RuvB_N PF05496.12 ETS63968.1 - 0.0011 18.8 0.0 0.0036 17.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETS63968.1 - 0.008 16.2 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ETS63968.1 - 0.0092 15.7 0.0 0.016 14.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETS63968.1 - 0.015 14.6 0.0 0.23 10.8 0.0 2.1 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI DNA_pol3_delta PF06144.13 ETS63968.1 - 0.018 14.8 0.1 0.028 14.2 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_11 PF13086.6 ETS63968.1 - 0.035 13.9 0.0 0.057 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain MipZ PF09140.11 ETS63968.1 - 0.066 12.5 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 ATPase MipZ DUF1302 PF06980.11 ETS63968.1 - 0.094 11.3 0.0 0.13 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1302) B12-binding_2 PF02607.17 ETS63968.1 - 0.1 13.1 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 B12 binding domain MeaB PF03308.16 ETS63968.1 - 0.13 11.3 0.0 0.28 10.1 0.0 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 ETS63968.1 - 0.13 12.6 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA C-terminal domain SNF2_N PF00176.23 ETS63969.1 - 5.3e-52 176.7 0.0 8.8e-52 175.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS63969.1 - 1e-20 74.1 0.0 2.8e-20 72.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ETS63969.1 - 1.5e-06 27.6 0.1 4.4e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ETS63969.1 - 2.3e-06 27.7 0.0 5.5e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zf_RING PF16744.5 ETS63969.1 - 6.5e-05 23.0 1.7 6.5e-05 23.0 1.7 2.8 3 0 0 3 3 3 1 KIAA1045 RING finger Chromo PF00385.24 ETS63969.1 - 0.00013 21.8 8.4 0.078 12.9 0.1 3.6 4 0 0 4 4 4 2 Chromo (CHRromatin Organisation MOdifier) domain zf-PHD-like PF15446.6 ETS63969.1 - 0.00036 20.2 6.6 0.4 10.3 2.8 3.3 2 1 0 2 2 2 2 PHD/FYVE-zinc-finger like domain PHD PF00628.29 ETS63969.1 - 0.0049 16.7 10.0 0.012 15.4 1.3 3.1 3 0 0 3 3 3 2 PHD-finger AAA_19 PF13245.6 ETS63969.1 - 0.091 13.1 0.0 0.36 11.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain C1_1 PF00130.22 ETS63969.1 - 2.4 8.1 11.6 1.4 8.9 0.0 3.4 4 1 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD_4 PF16866.5 ETS63969.1 - 3.5 7.8 16.5 0.5 10.5 2.2 4.4 4 0 0 4 4 4 0 PHD-finger ORC4_C PF14629.6 ETS63970.1 - 1.2e-44 152.3 0.0 2.1e-44 151.5 0.0 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 ETS63970.1 - 1.2e-22 81.1 1.1 1.2e-22 81.1 1.1 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 ETS63970.1 - 2.3e-06 28.1 0.0 0.067 13.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS63970.1 - 1.7e-05 25.1 0.0 0.00043 20.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ETS63970.1 - 0.00013 21.7 0.0 0.00038 20.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF815 PF05673.13 ETS63970.1 - 0.00026 20.2 0.0 0.0005 19.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ETS63970.1 - 0.0015 18.1 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 ETS63970.1 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETS63970.1 - 0.032 14.6 0.1 0.11 12.8 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETS63970.1 - 0.051 13.7 0.0 0.12 12.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ETS63970.1 - 0.053 13.4 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ETS63970.1 - 0.068 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 ETS63970.1 - 0.09 12.8 0.0 0.21 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Utp11 PF03998.13 ETS63972.1 - 9.3e-66 222.2 5.9 1.4e-65 221.7 5.9 1.3 1 0 0 1 1 1 1 Utp11 protein CtaG_Cox11 PF04442.14 ETS63972.1 - 5.4e-56 188.8 0.0 8.6e-56 188.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 JAKMIP_CC3 PF16034.5 ETS63972.1 - 0.0048 16.9 0.2 0.012 15.5 0.2 1.7 1 0 0 1 1 1 1 JAKMIP CC3 domain SLATT_5 PF18160.1 ETS63972.1 - 0.064 12.6 1.4 1.3 8.3 0.1 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 MFS_1 PF07690.16 ETS63973.1 - 2.4e-26 92.5 22.3 2.8e-25 89.0 23.1 1.8 2 0 0 2 2 2 1 Major Facilitator Superfamily Phage_holin_5_2 PF16079.5 ETS63973.1 - 0.37 11.1 6.3 1.2 9.5 1.9 3.3 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V Lig_chan PF00060.26 ETS63973.1 - 4.4 7.1 7.1 8.6 6.2 0.0 3.5 3 1 0 3 3 3 0 Ligand-gated ion channel MASE2 PF05230.11 ETS63974.1 - 0.0017 18.4 0.4 0.0044 17.1 0.4 1.7 1 0 0 1 1 1 1 MASE2 domain DUF4407 PF14362.6 ETS63974.1 - 0.069 12.5 1.0 0.1 12.0 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1240 PF06836.12 ETS63974.1 - 0.13 12.8 0.0 0.13 12.8 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1240) Tetraspanin PF00335.20 ETS63974.1 - 3.3 7.4 10.8 11 5.7 10.8 1.9 1 1 0 1 1 1 0 Tetraspanin family MMS1_N PF10433.9 ETS63975.1 - 1.3e-152 508.8 0.0 2.8e-152 507.8 0.0 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ETS63975.1 - 6e-91 305.1 0.1 5.5e-90 301.9 0.1 2.4 3 0 0 3 3 3 1 CPSF A subunit region RhoGEF PF00621.20 ETS63977.1 - 1.7e-41 142.5 0.0 2.7e-41 141.8 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain LRR_8 PF13855.6 ETS63977.1 - 1e-10 41.2 8.1 2.7e-05 23.8 0.2 2.6 1 1 1 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ETS63977.1 - 1.3e-08 35.0 3.1 3.2e-05 24.2 0.8 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETS63977.1 - 0.018 15.5 7.6 4.3 8.3 0.4 4.7 3 0 0 3 3 3 0 Leucine Rich Repeat DUF4724 PF15852.5 ETS63977.1 - 0.098 13.1 0.5 0.55 10.7 0.5 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4724) TLD PF07534.16 ETS63978.1 - 1.8e-28 99.5 0.0 5.9e-26 91.4 0.0 2.3 2 0 0 2 2 2 2 TLD RCC_reductase PF06405.11 ETS63979.1 - 0.031 13.5 0.0 0.071 12.3 0.0 1.5 2 0 0 2 2 2 0 Red chlorophyll catabolite reductase (RCC reductase) SMC_N PF02463.19 ETS63981.1 - 7.5e-27 94.2 0.0 2e-26 92.8 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ETS63981.1 - 9.7e-17 61.7 0.0 6.7e-14 52.4 0.0 2.9 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ETS63981.1 - 1.8e-12 48.2 26.5 1.8e-12 48.2 26.5 5.8 3 2 1 4 4 1 1 AAA domain AAA_29 PF13555.6 ETS63981.1 - 1.2e-05 25.0 0.1 2.3e-05 24.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ETS63981.1 - 0.00043 20.2 13.2 0.014 15.2 0.9 4.4 4 1 0 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system Tropomyosin PF00261.20 ETS63981.1 - 0.00094 18.6 3.7 0.00094 18.6 3.7 6.0 3 2 3 6 6 5 1 Tropomyosin IFT57 PF10498.9 ETS63981.1 - 0.0051 15.8 3.9 0.0051 15.8 3.9 6.1 4 2 2 6 6 5 1 Intra-flagellar transport protein 57 ABC_tran PF00005.27 ETS63981.1 - 0.0076 16.8 0.1 0.0076 16.8 0.1 5.7 3 2 1 4 4 2 1 ABC transporter TMF_DNA_bd PF12329.8 ETS63981.1 - 0.009 16.0 2.6 0.009 16.0 2.6 7.8 6 3 1 9 9 7 1 TATA element modulatory factor 1 DNA binding FtsK_SpoIIIE PF01580.18 ETS63981.1 - 0.038 13.3 0.0 0.038 13.3 0.0 3.6 4 0 0 4 4 4 0 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 ETS63981.1 - 0.064 13.1 0.0 0.42 10.5 0.0 2.4 1 0 0 1 1 1 0 RsgA GTPase EMC3_TMCO1 PF01956.16 ETS63981.1 - 5.4 6.7 0.0 5.4 6.7 0.0 4.5 3 2 0 3 3 2 0 Integral membrane protein EMC3/TMCO1-like MukB PF04310.12 ETS63981.1 - 7.2 6.3 8.1 13 5.5 0.0 3.4 3 0 0 3 3 3 0 MukB N-terminal ApbA_C PF08546.11 ETS63982.1 - 7.1e-37 126.4 0.0 1.2e-36 125.7 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ETS63982.1 - 3.2e-22 78.8 0.0 3.4e-18 65.7 0.0 2.4 2 0 0 2 2 2 2 Ketopantoate reductase PanE/ApbA DUF3591 PF12157.8 ETS63983.1 - 3.1e-185 616.0 1.6 4.8e-185 615.4 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 ETS63983.1 - 0.00022 21.0 3.4 0.00052 19.8 3.4 1.6 1 0 0 1 1 1 1 Zinc knuckle BLOC1S3 PF15753.5 ETS63983.1 - 0.19 11.9 3.1 0.32 11.1 1.8 2.1 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 zf-CCHC PF00098.23 ETS63983.1 - 0.25 11.5 1.2 0.54 10.4 1.2 1.6 1 0 0 1 1 1 0 Zinc knuckle PBP1_TM PF14812.6 ETS63984.1 - 0.07 13.5 5.9 0.27 11.6 3.1 3.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UTP25 PF06862.12 ETS63985.1 - 1.3e-182 607.9 0.9 1.5e-182 607.6 0.9 1.0 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 HNF-1_N PF04814.13 ETS63985.1 - 0.022 15.4 3.9 0.052 14.2 3.9 1.7 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DEAD PF00270.29 ETS63985.1 - 0.042 13.6 0.1 4.5 7.0 0.0 2.5 2 0 0 2 2 2 0 DEAD/DEAH box helicase MMR_HSR1 PF01926.23 ETS63986.1 - 1.7e-15 57.1 0.2 2.9e-14 53.1 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS63986.1 - 2.7e-07 30.6 0.1 0.0016 18.4 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ETS63986.1 - 1.8e-05 24.3 0.0 9.6e-05 21.9 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 ETS63986.1 - 0.012 15.0 0.0 0.024 13.9 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Dynamin_N PF00350.23 ETS63986.1 - 0.022 14.8 1.1 0.034 14.2 0.0 1.9 2 0 0 2 2 2 0 Dynamin family Retinin_C PF04527.12 ETS63986.1 - 0.036 14.3 0.6 1.3 9.4 0.3 2.4 2 0 0 2 2 2 0 Drosophila Retinin like protein RRN3 PF05327.11 ETS63986.1 - 0.096 11.2 3.1 0.16 10.5 3.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 cobW PF02492.19 ETS63986.1 - 0.14 11.7 0.0 2 8.0 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Nop14 PF04147.12 ETS63986.1 - 0.9 7.7 11.9 1.5 6.9 11.9 1.3 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 ETS63986.1 - 1.6 9.2 5.8 0.33 11.4 0.4 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETS63986.1 - 3.3 5.9 10.0 5.8 5.1 10.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Img2 PF05046.14 ETS63987.1 - 4.8e-24 84.4 0.0 8.1e-24 83.7 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) SecE PF00584.20 ETS63988.1 - 3.8e-10 39.5 0.4 0.00019 21.3 0.1 2.2 2 0 0 2 2 2 2 SecE/Sec61-gamma subunits of protein translocation complex Ribosomal_L29 PF00831.23 ETS63989.1 - 3.3e-19 68.6 1.9 3.3e-19 68.6 1.9 2.0 2 0 0 2 2 2 1 Ribosomal L29 protein SieB PF14163.6 ETS63989.1 - 0.038 13.5 0.3 0.064 12.7 0.2 1.5 1 1 0 1 1 1 0 Super-infection exclusion protein B HiaBD2 PF15403.6 ETS63989.1 - 0.19 12.2 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) DUF3460 PF11943.8 ETS63991.1 - 0.025 14.8 0.3 0.062 13.6 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3460) Nefa_Nip30_N PF10187.9 ETS63991.1 - 0.038 14.3 1.7 0.14 12.5 1.7 2.0 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 SF3b10 PF07189.11 ETS63993.1 - 2.4e-33 114.1 0.0 2.8e-33 113.9 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Zn_clus PF00172.18 ETS63995.1 - 0.00036 20.6 15.1 0.00053 20.0 15.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SNF2_N PF00176.23 ETS63996.1 - 4.4e-63 213.1 0.9 9e-63 212.1 0.9 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 ETS63996.1 - 2e-50 170.6 16.3 2e-50 170.6 16.3 2.5 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 ETS63996.1 - 4e-17 62.6 0.0 8.8e-17 61.5 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS63996.1 - 1.2e-06 28.6 0.0 2.7e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ETS63996.1 - 0.0024 17.1 0.1 0.0091 15.2 0.1 1.9 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Swi5 PF07061.11 ETS63999.1 - 2e-14 53.4 0.2 2.9e-14 52.9 0.2 1.2 1 0 0 1 1 1 1 Swi5 AATF-Che1 PF13339.6 ETS63999.1 - 0.15 12.8 0.1 0.18 12.5 0.1 1.2 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor Pex14_N PF04695.13 ETS64000.1 - 5.6e-24 85.6 0.2 1.7e-23 84.0 0.0 1.9 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region GDI PF00996.18 ETS64001.1 - 9.7e-210 696.6 0.0 1.1e-209 696.4 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 ETS64001.1 - 0.0054 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain MMM1 PF10296.9 ETS64002.1 - 1.4e-10 40.8 0.0 8.8e-09 34.9 0.0 2.4 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 SET PF00856.28 ETS64003.1 - 1.7e-07 31.8 0.0 1.2e-05 25.8 0.0 2.5 1 1 0 1 1 1 1 SET domain dCMP_cyt_deam_1 PF00383.23 ETS64003.1 - 0.00017 21.4 0.0 0.00036 20.4 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region HLH PF00010.26 ETS64004.1 - 0.0012 18.8 0.0 0.0072 16.3 0.0 2.1 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.13 ETS64004.1 - 0.4 10.6 9.1 0.033 14.2 4.6 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit GHMP_kinases_N PF00288.26 ETS64005.1 - 1.1e-14 54.4 1.9 3.6e-14 52.7 1.9 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ETS64005.1 - 2.9e-06 27.6 0.0 7e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal Telomerase_RBD PF12009.8 ETS64006.1 - 3.9e-40 137.0 0.1 2.2e-39 134.6 0.1 2.3 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 ETS64006.1 - 6.1e-12 45.5 0.0 3.3e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) MAS20 PF02064.15 ETS64006.1 - 1.1 9.3 6.0 0.83 9.8 0.2 2.5 2 0 0 2 2 2 0 MAS20 protein import receptor Pkinase PF00069.25 ETS64007.1 - 4.3e-47 160.7 0.0 3.6e-32 111.8 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64007.1 - 4.4e-23 81.9 0.0 3.8e-21 75.6 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 ETS64007.1 - 0.023 14.0 0.0 0.043 13.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ETS64007.1 - 0.11 11.9 0.2 0.18 11.2 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UPF0561 PF10573.9 ETS64008.1 - 0.072 13.2 0.3 0.15 12.2 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Choline_transpo PF04515.12 ETS64009.1 - 1.3 8.2 7.4 3.7 6.6 7.4 1.6 1 1 0 1 1 1 0 Plasma-membrane choline transporter Ank_4 PF13637.6 ETS64010.1 - 1e-10 41.9 0.0 2.1e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS64010.1 - 6.8e-07 29.8 0.1 1.4e-06 28.8 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETS64010.1 - 0.00088 19.6 0.0 0.031 14.8 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ETS64010.1 - 0.0015 18.9 0.3 0.0058 17.0 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETS64010.1 - 0.0098 16.2 0.0 0.03 14.6 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) zf-CCCH_2 PF14608.6 ETS64010.1 - 0.048 14.1 3.5 0.086 13.3 3.5 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ETS64010.1 - 0.16 11.8 1.9 0.27 11.1 1.9 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger PPR_2 PF13041.6 ETS64011.1 - 2.1e-05 24.6 0.3 1.6 9.0 0.0 4.7 5 0 0 5 5 5 2 PPR repeat family DUF4201 PF13870.6 ETS64011.1 - 0.0001 22.1 10.1 0.0001 22.1 10.1 23.9 3 1 17 25 25 25 7 Domain of unknown function (DUF4201) HMMR_N PF15905.5 ETS64011.1 - 0.0026 17.3 29.6 0.0026 17.3 29.6 14.5 3 1 7 14 14 14 3 Hyaluronan mediated motility receptor N-terminal Adaptin_N PF01602.20 ETS64012.1 - 5.1e-112 375.1 0.0 7.4e-112 374.6 0.0 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 ETS64012.1 - 1.2e-53 181.4 0.4 2.2e-53 180.4 0.4 1.5 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 ETS64012.1 - 3.7e-35 120.5 0.0 1.3e-34 118.8 0.0 2.0 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 ETS64012.1 - 2.2e-17 63.2 0.7 1e-09 38.6 0.1 5.6 3 2 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 ETS64012.1 - 2.2e-06 27.8 5.6 0.2 11.7 0.1 3.8 3 1 0 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETS64012.1 - 5.5e-05 23.1 4.2 6 7.4 0.2 5.8 5 0 0 5 5 5 2 HEAT repeat HEAT_PBS PF03130.16 ETS64012.1 - 0.45 11.3 3.3 14 6.7 0.1 4.7 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat zf-Nse PF11789.8 ETS64013.1 - 4.3e-13 48.9 0.1 8.1e-13 48.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 ETS64013.1 - 1.1e-05 25.6 0.0 2.1e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 U-box domain zf-C3HC4_2 PF13923.6 ETS64013.1 - 0.00047 19.9 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS64013.1 - 0.0028 17.6 0.0 0.0078 16.2 0.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETS64013.1 - 0.03 14.2 0.1 0.08 12.8 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 ETS64013.1 - 0.049 13.5 0.3 0.095 12.6 0.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETS64013.1 - 0.15 12.4 0.0 0.41 11.0 0.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain CTP_synth_N PF06418.14 ETS64014.1 - 1.7e-120 401.3 0.0 2.5e-120 400.7 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 ETS64014.1 - 2.1e-50 171.2 0.0 1.5e-39 135.8 0.0 2.3 2 0 0 2 2 2 2 Glutamine amidotransferase class-I CbiA PF01656.23 ETS64014.1 - 0.039 14.0 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Peptidase_C26 PF07722.13 ETS64014.1 - 0.14 11.9 0.1 1.2 8.9 0.0 2.3 2 0 0 2 2 2 0 Peptidase C26 Ribosomal_S28e PF01200.18 ETS64016.1 - 6.5e-28 96.5 2.0 1.9e-27 95.0 2.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S28e Haem_degrading PF03928.14 ETS64017.1 - 5.2e-30 103.9 0.0 6.5e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 Haem-degrading Ras PF00071.22 ETS64018.1 - 1.2e-54 184.3 0.0 1.3e-54 184.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS64018.1 - 1.7e-21 76.6 0.0 2.4e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS64018.1 - 6e-06 25.8 0.0 7.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family UQ_con PF00179.26 ETS64019.1 - 4.8e-23 81.3 0.0 1e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rav1p_C PF12234.8 ETS64020.1 - 3.6e-211 702.9 0.0 4.9e-211 702.5 0.0 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal PP-binding PF00550.25 ETS64021.1 - 5.7e-14 52.2 0.5 8.2e-14 51.7 0.5 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ETS64021.1 - 4.5e-08 33.2 0.6 6.4e-08 32.7 0.6 1.2 1 0 0 1 1 1 1 Acyl-carrier hnRNP_Q_AcD PF18360.1 ETS64021.1 - 0.16 11.9 0.1 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain Ribosomal_L17 PF01196.19 ETS64022.1 - 8.7e-30 103.5 0.2 4.5e-29 101.2 0.1 2.1 2 0 0 2 2 2 1 Ribosomal protein L17 PFK PF00365.20 ETS64022.1 - 0.028 13.7 0.0 0.046 13.0 0.0 1.3 1 0 0 1 1 1 0 Phosphofructokinase PPR_2 PF13041.6 ETS64023.1 - 2.1e-06 27.8 0.0 6 7.1 0.0 5.0 6 1 1 7 7 7 3 PPR repeat family PPR_long PF17177.4 ETS64023.1 - 0.00036 20.0 0.9 0.016 14.6 0.0 3.1 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 ETS64023.1 - 0.0021 18.1 0.2 6.6 6.9 0.1 4.3 3 1 2 5 5 5 1 Pentatricopeptide repeat domain PPR PF01535.20 ETS64023.1 - 0.0074 16.5 0.0 4.6 7.7 0.0 5.0 6 0 0 6 6 6 1 PPR repeat PPR_1 PF12854.7 ETS64023.1 - 0.019 14.6 0.0 0.92 9.3 0.0 3.2 3 0 0 3 3 3 0 PPR repeat B12-binding_2 PF02607.17 ETS64023.1 - 0.07 13.6 1.8 80 3.8 0.1 4.0 3 0 0 3 3 3 0 B12 binding domain TPR_14 PF13428.6 ETS64023.1 - 1.4 10.0 16.3 40 5.4 0.0 7.7 8 1 0 8 8 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETS64023.1 - 5.4 7.7 20.6 40 5.0 0.1 7.3 8 0 0 8 8 8 0 Tetratricopeptide repeat Dak2 PF02734.17 ETS64024.1 - 0.041 13.8 0.8 0.25 11.2 0.7 2.0 2 0 0 2 2 2 0 DAK2 domain DUF948 PF06103.11 ETS64024.1 - 0.066 13.5 0.2 15 5.9 0.1 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PEP-CTERM PF07589.11 ETS64024.1 - 0.084 13.0 1.3 0.2 11.8 1.3 1.6 1 0 0 1 1 1 0 PEP-CTERM motif DUF3072 PF11272.8 ETS64024.1 - 0.67 9.9 3.0 2 8.4 3.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3072) PH PF00169.29 ETS64025.1 - 2.5e-06 27.9 0.0 0.047 14.2 0.0 2.8 2 1 0 2 2 2 2 PH domain PH_11 PF15413.6 ETS64025.1 - 0.0042 17.5 0.0 3.4 8.1 0.0 2.6 2 0 0 2 2 2 2 Pleckstrin homology domain Bin3 PF06859.12 ETS64026.1 - 1.3e-30 106.2 0.0 2.7e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Heme_oxygenase PF01126.20 ETS64026.1 - 2e-23 83.3 0.0 1.3e-19 70.8 0.0 2.8 2 1 0 2 2 2 2 Heme oxygenase Methyltransf_12 PF08242.12 ETS64026.1 - 1.3e-09 38.7 0.0 7.4e-05 23.4 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ETS64026.1 - 1.1e-08 35.6 0.0 0.00034 21.3 0.0 3.0 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ETS64026.1 - 1.6e-08 34.5 0.0 6.1e-07 29.3 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS64026.1 - 2.3e-08 34.0 0.0 5e-08 33.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS64026.1 - 1.3e-07 32.2 0.0 0.016 15.8 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_32 PF13679.6 ETS64026.1 - 0.0015 18.5 0.0 0.0031 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 ETS64026.1 - 0.0055 16.2 0.0 0.031 13.7 0.0 2.0 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain NCBP3 PF10309.9 ETS64027.1 - 9e-06 25.4 0.0 2.1e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 ETS64027.1 - 0.0021 18.0 0.0 0.004 17.2 0.0 1.4 1 0 0 1 1 1 1 RNA binding domain Rsm22 PF09243.10 ETS64028.1 - 7.9e-28 97.5 0.1 1.7e-13 50.5 0.0 4.6 4 1 0 4 4 4 4 Mitochondrial small ribosomal subunit Rsm22 Ima1_N PF09779.9 ETS64029.1 - 5.5e-21 75.8 1.5 5.5e-21 75.8 1.5 2.3 2 0 0 2 2 2 1 Ima1 N-terminal domain Lyase_1 PF00206.20 ETS64030.1 - 8.6e-118 393.3 0.0 1.3e-117 392.7 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ETS64030.1 - 1.6e-19 70.1 1.0 4.1e-18 65.5 0.2 2.6 2 0 0 2 2 2 1 Fumarase C C-terminus PilA4 PF18682.1 ETS64030.1 - 0.078 13.4 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 Pilin A4 MMR_HSR1 PF01926.23 ETS64031.1 - 3.3e-11 43.3 0.0 1.1e-10 41.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ETS64031.1 - 0.048 14.0 0.2 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 ETS64031.1 - 0.08 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 ETS64031.1 - 0.13 12.0 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Carn_acyltransf PF00755.20 ETS64032.1 - 7.5e-196 652.3 0.0 8.7e-196 652.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase AMP-binding PF00501.28 ETS64033.1 - 8.3e-48 163.0 0.0 1.2e-47 162.4 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 ETS64033.1 - 3.9e-13 49.6 0.5 1e-12 48.2 0.5 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.24 ETS64033.1 - 2.9e-10 39.5 5.1 0.0045 16.7 0.1 7.0 8 0 0 8 8 8 3 Bacterial transferase hexapeptide (six repeats) AMP-binding_C PF13193.6 ETS64033.1 - 7.7e-05 23.6 2.0 0.031 15.3 0.0 3.0 3 0 0 3 3 3 2 AMP-binding enzyme C-terminal domain GH3 PF03321.13 ETS64033.1 - 0.1 11.4 0.0 1.6 7.5 0.0 2.0 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Hexapep_2 PF14602.6 ETS64033.1 - 0.11 12.3 7.8 4 7.3 0.0 4.8 4 1 1 5 5 5 0 Hexapeptide repeat of succinyl-transferase ERAP1_C PF11838.8 ETS64035.1 - 1.4e-75 254.8 0.9 2.3e-75 254.1 0.9 1.4 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 ETS64035.1 - 6.4e-69 231.8 0.0 9.3e-69 231.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ETS64035.1 - 2.9e-42 145.0 1.9 1.7e-38 132.7 0.1 2.4 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain SKN1 PF03935.15 ETS64039.1 - 1.4e-189 630.7 4.5 1.7e-189 630.4 4.5 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) Neurensin PF14927.6 ETS64039.1 - 0.15 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 Neurensin PfkB PF00294.24 ETS64040.1 - 1.6e-64 218.1 5.0 1.9e-64 217.9 5.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ETS64040.1 - 8.5e-06 25.3 0.0 2e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Fer2_3 PF13085.6 ETS64040.1 - 0.16 12.0 0.1 0.51 10.4 0.0 1.8 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain SNF2_N PF00176.23 ETS64041.1 - 1.6e-66 224.4 0.0 2.3e-66 223.9 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 ETS64041.1 - 1.3e-29 101.9 0.0 2.5e-29 101.0 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 ETS64041.1 - 8e-13 48.7 0.0 1.7e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_5 PF14634.6 ETS64041.1 - 0.00017 21.5 11.7 0.0003 20.7 11.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain ResIII PF04851.15 ETS64041.1 - 0.00086 19.4 0.0 0.8 9.7 0.0 2.9 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit zf-RING_2 PF13639.6 ETS64041.1 - 0.0022 18.3 12.3 0.0038 17.5 12.3 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETS64041.1 - 0.0044 16.9 12.8 0.0075 16.1 12.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS64041.1 - 0.2 11.7 9.7 0.42 10.7 9.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETS64041.1 - 1 9.2 14.2 3.2 7.7 14.2 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cupin_8 PF13621.6 ETS64042.1 - 1.6e-12 47.7 0.0 1.1e-11 44.9 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ETS64042.1 - 1.6e-08 35.0 0.4 9.6e-08 32.5 0.0 2.5 2 1 0 2 2 2 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 ETS64042.1 - 0.0013 18.3 0.0 0.0043 16.6 0.0 1.9 2 0 0 2 2 2 1 Cupin superfamily protein Cupin_1 PF00190.22 ETS64042.1 - 0.031 13.9 0.0 0.068 12.8 0.0 1.5 1 0 0 1 1 1 0 Cupin F-box-like PF12937.7 ETS64042.1 - 0.094 12.6 1.3 0.24 11.4 0.0 2.2 2 0 0 2 2 2 0 F-box-like Cupin_2 PF07883.11 ETS64042.1 - 0.13 12.0 0.0 0.6 9.9 0.0 2.0 2 0 0 2 2 2 0 Cupin domain Sugar_tr PF00083.24 ETS64043.1 - 1.7e-39 135.9 15.0 3.5e-20 72.3 3.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETS64043.1 - 2.8e-17 62.7 43.8 2.2e-08 33.4 16.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Raptor_N PF14538.6 ETS64044.1 - 1.4e-60 203.6 0.0 2.3e-60 202.8 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 ETS64044.1 - 5.1e-06 27.1 7.7 1.9 9.5 0.0 5.7 5 0 0 5 5 5 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETS64044.1 - 2.9e-05 24.1 0.0 0.0067 16.5 0.0 2.7 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region HEAT PF02985.22 ETS64044.1 - 9.8e-05 22.3 6.5 0.041 14.2 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ETS64044.1 - 0.07 13.5 0.5 1.2 9.5 0.1 3.2 3 1 0 3 3 3 0 HEAT repeats Cnd1 PF12717.7 ETS64044.1 - 0.16 12.0 0.2 0.57 10.2 0.0 2.0 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 CAF1C_H4-bd PF12265.8 ETS64045.1 - 3.4e-16 59.3 0.1 9.3e-16 57.9 0.0 1.8 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ETS64045.1 - 6.1e-16 58.5 5.7 5.7e-06 27.0 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Zip PF02535.22 ETS64046.1 - 1.2e-25 90.5 28.6 9.4e-22 77.7 17.2 2.8 2 1 0 2 2 2 2 ZIP Zinc transporter Tmemb_55A PF09788.9 ETS64046.1 - 0.21 10.7 0.9 0.39 9.7 0.0 1.7 2 0 0 2 2 2 0 Transmembrane protein 55A CHD5 PF04420.14 ETS64047.1 - 5.3e-53 179.1 2.6 8.8e-53 178.4 2.6 1.3 1 0 0 1 1 1 1 CHD5-like protein DivIC PF04977.15 ETS64047.1 - 0.028 14.2 0.1 0.1 12.4 0.1 2.0 1 1 0 1 1 1 0 Septum formation initiator RCC1_2 PF13540.6 ETS64048.1 - 7.1e-13 48.0 9.0 3.2e-08 33.2 1.3 4.4 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETS64048.1 - 8.7e-10 39.1 0.3 0.32 11.7 0.0 4.8 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat RRM_1 PF00076.22 ETS64049.1 - 2.1e-13 49.9 0.1 1.7e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS64049.1 - 9.8e-05 22.0 0.0 0.0018 17.9 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Myb_DNA-bind_7 PF15963.5 ETS64050.1 - 1.4e-24 85.7 0.0 3.9e-24 84.4 0.0 1.7 1 0 0 1 1 1 1 Myb DNA-binding like HMG_box PF00505.19 ETS64050.1 - 5.8e-15 55.5 0.1 2e-14 53.8 0.0 1.9 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS64050.1 - 9e-07 29.4 0.0 2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 HMG-box domain Myb_DNA-binding PF00249.31 ETS64050.1 - 1.1e-06 28.8 0.0 2.1e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Abhydrolase_6 PF12697.7 ETS64051.1 - 3.3e-11 44.2 0.1 4.4e-11 43.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETS64051.1 - 5.6e-06 25.8 0.1 2.5e-05 23.7 0.1 1.9 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS64051.1 - 0.0035 17.0 0.6 0.0083 15.8 0.2 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_8 PF06259.12 ETS64051.1 - 0.016 14.9 0.2 0.026 14.1 0.2 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Peptidase_S9 PF00326.21 ETS64051.1 - 0.05 13.1 0.4 0.94 8.9 0.2 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family 4HBT_2 PF13279.6 ETS64052.1 - 8.1e-08 32.8 0.0 1.3e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 ETS64052.1 - 1.3e-07 31.8 0.0 2.2e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 ETS64052.1 - 1.7e-05 24.3 0.0 0.021 14.1 0.0 2.1 2 0 0 2 2 2 2 Acyl-ACP thioesterase Haspin_kinase PF12330.8 ETS64053.1 - 1.8e-56 191.7 0.0 4.5e-56 190.4 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_Tyr PF07714.17 ETS64053.1 - 0.0014 17.9 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETS64053.1 - 0.051 12.9 0.0 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain Ribosomal_L1 PF00687.21 ETS64054.1 - 1.3e-20 74.0 0.1 5.9e-20 71.9 0.1 1.9 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family GARS_A PF01071.19 ETS64055.1 - 1.1e-71 240.7 0.0 1.5e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 ETS64055.1 - 5.7e-32 111.0 0.0 1.2e-31 110.0 0.0 1.6 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 ETS64055.1 - 2.9e-29 101.7 0.0 1.2e-28 99.7 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 ETS64055.1 - 4.1e-28 97.5 0.4 1e-27 96.2 0.4 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 ETS64055.1 - 5.4e-14 52.6 0.5 6.6e-13 49.1 0.9 2.5 2 0 0 2 2 2 1 AIR synthase related protein, N-terminal domain Alba PF01918.21 ETS64055.1 - 0.13 12.1 0.1 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 Alba Pyr_redox_2 PF07992.14 ETS64056.1 - 3.7e-27 95.3 0.0 2.5e-14 53.2 0.0 4.1 3 1 1 4 4 4 4 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS64056.1 - 8.2e-15 55.1 0.0 1.3e-10 41.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETS64056.1 - 0.0072 15.6 0.1 0.64 9.2 0.0 2.5 3 0 0 3 3 3 1 Thi4 family Pyr_redox_3 PF13738.6 ETS64056.1 - 0.022 14.0 0.0 5.6 6.1 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETS64056.1 - 0.022 13.6 0.1 2.4 6.9 0.0 2.8 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_8 PF13450.6 ETS64056.1 - 0.03 14.5 0.0 3.6 7.9 0.0 2.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETS64056.1 - 0.038 13.6 0.2 14 5.1 0.0 3.1 3 0 0 3 3 3 0 FAD dependent oxidoreductase HI0933_like PF03486.14 ETS64056.1 - 0.094 11.4 0.1 11 4.6 0.0 2.7 3 0 0 3 3 3 0 HI0933-like protein UDPG_MGDP_dh_N PF03721.14 ETS64057.1 - 0.26 10.8 0.0 0.46 10.0 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain MFS_1 PF07690.16 ETS64059.1 - 2.6e-26 92.4 32.4 7e-26 91.0 29.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4834 PF16118.5 ETS64059.1 - 0.33 12.0 0.7 1.7 9.6 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) PCI PF01399.27 ETS64060.1 - 3.8e-21 75.6 0.9 7.8e-21 74.6 0.9 1.6 1 0 0 1 1 1 1 PCI domain FmiP_Thoc5 PF09766.9 ETS64060.1 - 0.0093 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 E3_UFM1_ligase PF09743.9 ETS64060.1 - 0.035 13.7 0.5 4.5 6.8 0.0 2.1 2 0 0 2 2 2 0 E3 UFM1-protein ligase 1 TPR_10 PF13374.6 ETS64060.1 - 0.069 13.0 0.1 1.9 8.5 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M18 PF02127.15 ETS64061.1 - 6.9e-166 552.3 0.0 8.8e-166 552.0 0.0 1.1 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Acyltransferase PF01553.21 ETS64061.1 - 4.4e-20 71.7 0.0 9.6e-20 70.6 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Peptidase_M42 PF05343.14 ETS64061.1 - 0.0038 16.3 0.0 1.3 7.9 0.0 2.3 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase MarR PF01047.22 ETS64061.1 - 0.13 12.2 0.0 0.52 10.3 0.0 2.0 2 0 0 2 2 2 0 MarR family IBN_N PF03810.19 ETS64062.1 - 7.2e-08 32.2 0.0 6.6e-07 29.2 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain CAS_CSE1 PF03378.15 ETS64062.1 - 0.00064 18.3 0.0 0.027 12.9 0.0 2.6 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Urb2 PF10441.9 ETS64062.1 - 0.0067 16.4 0.1 0.76 9.7 0.0 3.6 4 0 0 4 4 4 1 Urb2/Npa2 family HEAT PF02985.22 ETS64062.1 - 0.017 15.3 4.1 1.9 9.0 0.0 5.2 5 0 0 5 5 5 0 HEAT repeat HRM PF02793.22 ETS64062.1 - 0.17 12.2 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 Hormone receptor domain Tyrosinase PF00264.20 ETS64064.1 - 2.7e-37 129.2 1.9 4.1e-37 128.6 1.9 1.3 1 0 0 1 1 1 1 Common central domain of tyrosinase HMG_box_2 PF09011.10 ETS64064.1 - 0.065 13.8 0.1 0.13 12.9 0.1 1.4 1 0 0 1 1 1 0 HMG-box domain DUF5329 PF17263.2 ETS64065.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5329) Dioxygenase_C PF00775.21 ETS64066.1 - 2.4e-07 30.4 0.0 4e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Dioxygenase NmrA PF05368.13 ETS64068.1 - 2.6e-47 161.3 0.1 3.2e-47 161.0 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ETS64068.1 - 2.7e-15 56.7 0.1 3.9e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ETS64068.1 - 0.00054 19.1 0.0 0.00082 18.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETS64068.1 - 0.0026 17.3 0.1 0.005 16.3 0.1 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family TrkA_N PF02254.18 ETS64068.1 - 0.006 16.8 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 ETS64068.1 - 0.082 13.2 0.0 0.16 12.2 0.0 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain VHS PF00790.19 ETS64069.1 - 8.5e-39 132.6 4.7 1.2e-38 132.1 0.1 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 ETS64069.1 - 7.9e-17 61.2 10.4 1.5e-16 60.2 10.4 1.4 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 ETS64069.1 - 7.6e-06 25.5 6.3 0.011 15.6 0.9 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif FYVE_2 PF02318.16 ETS64069.1 - 0.0039 17.4 4.3 0.0079 16.4 4.3 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger OAD_gamma PF04277.13 ETS64069.1 - 0.012 16.2 0.2 0.073 13.7 0.2 2.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain GAT PF03127.14 ETS64069.1 - 0.021 15.1 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 GAT domain ENTH PF01417.20 ETS64069.1 - 0.064 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 ENTH domain zf-RING_5 PF14634.6 ETS64069.1 - 4.8 7.2 10.6 9.1 6.3 10.6 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 ETS64069.1 - 8 6.9 9.4 14 6.1 9.4 1.4 1 0 0 1 1 1 0 Ring finger domain RNA_pol_Rpb1_5 PF04998.17 ETS64070.1 - 4.7e-104 347.5 0.1 6.3e-104 347.1 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 ETS64070.1 - 1.6e-103 346.3 0.0 2.3e-103 345.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 ETS64070.1 - 9e-72 240.7 0.0 2.2e-71 239.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 ETS64070.1 - 5.9e-58 195.8 0.1 1.4e-57 194.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 ETS64070.1 - 1.7e-47 160.8 1.2 3.5e-47 159.8 1.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 ETS64070.1 - 4.4e-45 153.4 0.0 8.3e-45 152.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ETS64070.1 - 2e-36 124.2 0.0 4.5e-36 123.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 ETS64070.1 - 1.4e-17 63.0 192.8 0.0088 16.4 8.8 14.2 9 2 5 15 15 15 14 RNA polymerase Rpb1 C-terminal repeat RhoGAP PF00620.27 ETS64071.1 - 1.9e-46 157.7 0.7 2.5e-45 154.0 0.0 2.5 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 ETS64071.1 - 2.5e-15 56.4 18.5 7e-09 35.8 2.6 3.3 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 ETS64071.1 - 9.5e-07 28.6 8.4 9.5e-07 28.6 8.4 4.2 3 1 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3450 PF11932.8 ETS64071.1 - 0.0021 17.4 2.6 0.0021 17.4 2.6 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) Nup88 PF10168.9 ETS64071.1 - 0.029 12.2 0.1 0.029 12.2 0.1 2.3 2 0 0 2 2 2 0 Nuclear pore component Suppressor_APC PF11414.8 ETS64071.1 - 0.3 11.2 10.0 0.017 15.1 2.5 2.7 2 1 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein YabA PF06156.13 ETS64071.1 - 1.5 9.5 14.0 0.42 11.3 1.7 3.2 2 1 0 2 2 2 0 Initiation control protein YabA Rotamase_2 PF13145.6 ETS64071.1 - 6.3 7.7 9.8 19 6.1 1.0 3.4 3 0 0 3 3 3 0 PPIC-type PPIASE domain Ras PF00071.22 ETS64072.1 - 6.9e-66 220.8 0.0 8.3e-66 220.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS64072.1 - 1.3e-33 115.8 0.1 2e-33 115.1 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS64072.1 - 6.1e-14 51.9 0.0 7.5e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETS64072.1 - 1e-05 25.0 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETS64072.1 - 4.1e-05 23.2 0.1 0.0001 21.9 0.0 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETS64072.1 - 4.1e-05 23.6 0.0 0.00012 22.2 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS64072.1 - 4.5e-05 23.4 0.0 0.28 11.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ETS64072.1 - 0.001 18.6 0.0 0.01 15.4 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ETS64072.1 - 0.0036 16.8 0.0 0.0045 16.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ETS64072.1 - 0.013 15.9 0.0 0.019 15.4 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain MCM PF00493.23 ETS64072.1 - 0.029 13.5 0.0 0.32 10.0 0.0 2.0 2 0 0 2 2 2 0 MCM P-loop domain AAA_29 PF13555.6 ETS64072.1 - 0.044 13.5 0.0 0.14 11.9 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain NACHT PF05729.12 ETS64072.1 - 0.055 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Septin PF00735.18 ETS64072.1 - 0.082 12.2 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 Septin AAA PF00004.29 ETS64072.1 - 0.1 13.0 0.0 0.6 10.5 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS64072.1 - 0.18 12.1 0.0 0.82 9.9 0.0 2.0 1 1 1 2 2 2 0 AAA domain U3_assoc_6 PF08640.11 ETS64073.1 - 2.1e-20 72.5 0.1 8.6e-19 67.4 0.0 2.7 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 ETS64073.1 - 0.0014 19.3 7.4 4.3 8.4 0.0 5.8 3 1 1 4 4 4 2 Tetratricopeptide repeat IFT20 PF14931.6 ETS64073.1 - 0.15 12.3 1.1 0.29 11.3 0.2 2.0 2 0 0 2 2 2 0 Intraflagellar transport complex B, subunit 20 ATP11 PF06644.11 ETS64074.1 - 3e-76 256.8 2.2 4.1e-76 256.4 2.2 1.2 1 0 0 1 1 1 1 ATP11 protein ABC_membrane PF00664.23 ETS64075.1 - 5.1e-50 170.7 12.0 9e-28 97.7 1.7 3.5 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 ETS64075.1 - 2.8e-44 151.0 0.0 2.8e-25 89.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ETS64075.1 - 1.7e-09 37.5 0.6 8.7e-05 22.1 0.0 4.0 3 1 1 4 4 4 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS64075.1 - 2.7e-05 23.8 0.1 0.083 12.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ETS64075.1 - 4.4e-05 23.9 1.4 0.09 13.2 0.1 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ETS64075.1 - 6.8e-05 23.2 0.4 0.94 9.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.6 ETS64075.1 - 0.00036 20.2 0.0 0.071 12.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ETS64075.1 - 0.00045 20.0 0.1 0.02 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ETS64075.1 - 0.00068 19.5 0.4 10 5.9 0.1 3.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system T2SSE PF00437.20 ETS64075.1 - 0.0011 18.2 0.0 0.14 11.1 0.1 2.4 2 0 0 2 2 2 1 Type II/IV secretion system protein cobW PF02492.19 ETS64075.1 - 0.0066 16.0 2.3 0.022 14.3 0.4 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ETS64075.1 - 0.008 16.2 0.1 1.6 8.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ETS64075.1 - 0.0098 16.4 4.4 1.2 9.6 0.0 2.7 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 ETS64075.1 - 0.01 15.8 0.3 0.95 9.4 0.0 2.7 2 0 0 2 2 2 0 NACHT domain DEAD PF00270.29 ETS64075.1 - 0.023 14.5 0.1 8.7 6.1 0.0 3.2 3 0 0 3 3 3 0 DEAD/DEAH box helicase AAA_30 PF13604.6 ETS64075.1 - 0.031 14.0 0.6 0.86 9.3 0.0 3.0 3 1 0 3 3 3 0 AAA domain SbcCD_C PF13558.6 ETS64075.1 - 0.04 14.2 0.3 8.3 6.7 0.0 2.8 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 ETS64075.1 - 0.043 13.7 0.0 1.9 8.4 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 ETS64075.1 - 0.069 13.3 0.8 2.8 8.1 0.2 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ETS64075.1 - 0.074 12.2 0.1 3.9 6.6 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain DUF87 PF01935.17 ETS64075.1 - 0.1 12.7 0.1 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain ATP_bind_1 PF03029.17 ETS64075.1 - 0.12 12.1 2.1 2.2 8.0 0.1 2.9 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Zeta_toxin PF06414.12 ETS64075.1 - 0.15 11.3 0.0 21 4.3 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin FtsK_SpoIIIE PF01580.18 ETS64075.1 - 0.16 11.3 0.4 20 4.4 0.3 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.6 ETS64075.1 - 0.28 11.7 0.7 18 5.9 0.2 2.8 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ETS64075.1 - 0.43 10.5 1.7 34 4.3 0.1 3.0 3 0 0 3 3 3 0 NTPase DUF2569 PF10754.9 ETS64075.1 - 1.8 9.0 11.6 0.18 12.2 3.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Asp PF00026.23 ETS64076.1 - 6.6e-40 137.5 0.0 3.3e-39 135.2 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS64076.1 - 9.5e-14 52.0 1.2 1.6e-11 44.8 0.2 2.7 3 0 0 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS64076.1 - 1.2e-06 29.1 0.1 0.012 16.2 0.0 3.7 2 1 1 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 ETS64076.1 - 0.025 15.1 0.0 1.5 9.5 0.0 3.0 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease PhoD PF09423.10 ETS64078.1 - 1.2e-36 126.4 0.6 6e-36 124.2 0.5 2.1 1 1 0 1 1 1 1 PhoD-like phosphatase NADH_B2 PF14813.6 ETS64079.1 - 0.00016 21.4 0.8 0.00033 20.4 0.8 1.5 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 E1_dh PF00676.20 ETS64080.1 - 3e-110 367.9 0.2 3.6e-110 367.6 0.2 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ETS64080.1 - 0.0016 17.7 0.1 0.0028 16.9 0.1 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ETS64080.1 - 0.0048 16.7 2.6 0.0048 16.7 2.6 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Nucleoporin_N PF08801.11 ETS64081.1 - 7.2e-45 153.5 0.0 1e-44 153.0 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 ETS64081.1 - 3.8e-32 111.8 2.6 5.5e-32 111.3 2.6 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal BC10 PF06726.12 ETS64081.1 - 0.062 13.5 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 Bladder cancer-related protein BC10 Adenylsucc_synt PF00709.21 ETS64082.1 - 1.4e-175 584.2 0.0 1.6e-175 584.0 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase GATase_2 PF00310.21 ETS64084.1 - 1.7e-175 583.8 0.0 2.2e-175 583.4 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 ETS64084.1 - 6.5e-156 519.1 0.1 1.3e-155 518.1 0.0 1.5 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 ETS64084.1 - 5.1e-116 387.0 0.1 1.4e-113 379.0 0.0 2.6 3 0 0 3 3 3 1 Glutamate synthase central domain GXGXG PF01493.19 ETS64084.1 - 1.3e-85 285.8 1.3 2e-85 285.2 1.3 1.3 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 ETS64084.1 - 3e-22 79.2 0.1 4.4e-21 75.4 0.1 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 ETS64084.1 - 7.5e-21 74.0 0.1 1.5e-20 73.1 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 ETS64084.1 - 2.2e-09 37.4 0.3 1.1e-08 35.2 0.1 2.4 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ETS64084.1 - 5.1e-09 36.6 0.3 3.4e-05 24.3 0.0 3.5 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS64084.1 - 1.6e-06 27.1 2.1 8.2e-06 24.8 0.2 2.4 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 ETS64084.1 - 4.5e-06 26.0 0.8 0.016 14.3 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ETS64084.1 - 5e-06 26.0 1.0 0.019 14.3 0.1 2.7 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ETS64084.1 - 6.9e-06 25.6 0.0 1.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 ETS64084.1 - 9.1e-06 25.0 2.5 0.00027 20.1 0.1 2.5 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ETS64084.1 - 1.4e-05 24.7 5.3 0.00043 19.8 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase DAO PF01266.24 ETS64084.1 - 0.00027 20.6 1.0 0.0038 16.9 0.3 2.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase FMN_dh PF01070.18 ETS64084.1 - 0.00066 18.8 1.0 0.004 16.2 0.9 2.1 2 0 0 2 2 2 1 FMN-dependent dehydrogenase AdoHcyase_NAD PF00670.21 ETS64084.1 - 0.003 17.6 1.9 0.9 9.6 0.3 3.4 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 ETS64084.1 - 0.0043 17.5 0.1 1.9 8.9 0.1 2.7 2 0 0 2 2 2 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ETS64084.1 - 0.0053 16.0 0.4 0.015 14.6 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 ETS64084.1 - 0.02 14.0 0.4 0.69 8.9 0.1 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_Gly3P_dh_N PF01210.23 ETS64084.1 - 0.032 14.2 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 ETS64084.1 - 0.037 13.3 0.5 8.7 5.6 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.19 ETS64084.1 - 0.091 11.2 0.2 1.6 7.0 0.0 2.5 3 0 0 3 3 3 0 Flavin-binding monooxygenase-like Thi4 PF01946.17 ETS64084.1 - 0.095 11.9 1.9 0.16 11.2 0.2 2.0 2 0 0 2 2 2 0 Thi4 family GATase_6 PF13522.6 ETS64084.1 - 0.12 12.5 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Glutamine amidotransferase domain 2-Hacid_dh_C PF02826.19 ETS64084.1 - 0.15 11.4 0.0 0.66 9.3 0.0 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ETS64084.1 - 0.18 11.4 1.0 0.94 9.0 0.1 2.5 3 0 0 3 3 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain 3HCDH_N PF02737.18 ETS64084.1 - 0.2 11.5 0.2 0.46 10.4 0.2 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MFS_1 PF07690.16 ETS64085.1 - 3.7e-28 98.5 28.1 3.7e-28 98.5 28.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Pyr_redox_2 PF07992.14 ETS64086.1 - 1.2e-40 139.6 0.0 2.2e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR PF01077.22 ETS64086.1 - 9.8e-20 70.7 0.0 1.8e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Pyr_redox PF00070.27 ETS64086.1 - 2.6e-13 50.3 1.3 9e-13 48.6 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Fer2_BFD PF04324.15 ETS64086.1 - 1.4e-12 47.7 8.0 2.7e-10 40.4 3.6 3.1 3 0 0 3 3 3 2 BFD-like [2Fe-2S] binding domain NIR_SIR_ferr PF03460.17 ETS64086.1 - 2.8e-12 46.3 0.0 6.3e-12 45.2 0.0 1.7 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain Rieske_2 PF13806.6 ETS64086.1 - 3e-12 46.4 0.0 9.2e-12 44.8 0.0 1.9 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Rieske PF00355.26 ETS64086.1 - 5.1e-10 39.2 0.2 1.4e-09 37.8 0.0 1.8 2 0 0 2 2 2 1 Rieske [2Fe-2S] domain NAD_binding_9 PF13454.6 ETS64086.1 - 9.9e-05 22.4 0.3 3.1 7.8 0.0 3.5 2 1 1 3 3 3 2 FAD-NAD(P)-binding Rubredoxin_C PF18267.1 ETS64086.1 - 0.00029 20.7 0.5 1.1 9.2 0.1 2.7 2 0 0 2 2 2 2 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox_3 PF13738.6 ETS64086.1 - 0.016 14.5 0.0 1.7 7.8 0.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS64086.1 - 0.1 11.6 3.0 0.27 10.3 0.3 2.6 1 1 1 2 2 2 0 FAD binding domain TrkA_N PF02254.18 ETS64086.1 - 0.21 11.9 1.0 5.9 7.2 0.1 3.0 3 0 0 3 3 3 0 TrkA-N domain Oxidored_molyb PF00174.19 ETS64087.1 - 2.9e-56 189.8 0.0 6.5e-56 188.6 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ETS64087.1 - 3.3e-45 153.5 0.1 6.4e-45 152.6 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.21 ETS64087.1 - 2.2e-30 105.5 0.0 4.9e-30 104.4 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ETS64087.1 - 1.7e-23 82.9 0.0 4.8e-23 81.4 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 ETS64087.1 - 1.2e-20 73.5 0.1 2.7e-20 72.3 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 ETS64087.1 - 0.016 15.3 0.0 0.073 13.2 0.0 2.0 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Ribosomal_L3 PF00297.22 ETS64088.1 - 2.9e-171 569.4 7.8 3.8e-171 569.1 7.8 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 CybS PF05328.12 ETS64089.1 - 1e-41 141.8 0.0 1.5e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Brix PF04427.18 ETS64090.1 - 1.8e-47 161.9 0.0 3.1e-47 161.2 0.0 1.3 1 0 0 1 1 1 1 Brix domain PPL5 PF18168.1 ETS64090.1 - 1.6 7.9 9.3 0.26 10.6 5.1 1.7 1 1 1 2 2 2 0 Prim-pol family 5 PPP4R2 PF09184.11 ETS64090.1 - 2.1 7.8 18.7 4.5 6.8 18.7 1.6 1 0 0 1 1 1 0 PPP4R2 Zn_clus PF00172.18 ETS64091.1 - 4.4e-08 33.1 6.8 4.4e-08 33.1 6.8 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TPR_19 PF14559.6 ETS64092.1 - 4.7e-06 27.0 5.0 0.55 10.8 1.8 7.2 8 0 0 8 8 8 1 Tetratricopeptide repeat NRDE-2 PF08424.10 ETS64092.1 - 5.8e-06 25.6 6.2 0.0032 16.7 0.0 4.8 3 1 0 4 4 4 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 ETS64092.1 - 1.2e-05 25.8 35.6 18 6.5 0.1 13.5 12 3 4 16 16 16 1 Tetratricopeptide repeat Suf PF05843.14 ETS64092.1 - 0.017 15.1 14.3 1.9 8.4 3.3 5.9 3 2 1 5 5 5 0 Suppressor of forked protein (Suf) Mad3_BUB1_I PF08311.12 ETS64092.1 - 0.061 13.3 11.9 0.27 11.2 1.1 6.2 6 2 1 7 7 7 0 Mad3/BUB1 homology region 1 TPR_8 PF13181.6 ETS64092.1 - 0.87 10.0 12.7 21 5.6 0.1 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETS64092.1 - 0.98 9.7 19.3 11 6.5 0.0 8.3 11 0 0 11 11 11 0 Tetratricopeptide repeat HAT PF02184.16 ETS64092.1 - 7.6 6.6 9.0 3.7 7.6 0.0 5.1 7 0 0 7 7 7 0 HAT (Half-A-TPR) repeat Ribonuc_2-5A PF06479.12 ETS64093.1 - 2.1e-44 150.7 0.1 3.9e-44 149.9 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 ETS64093.1 - 2.6e-38 131.9 0.0 1.6e-37 129.3 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64093.1 - 6.2e-19 68.3 0.0 2.8e-18 66.2 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_2 PF13360.6 ETS64093.1 - 1.2e-05 25.1 0.5 0.00095 18.8 0.0 3.0 2 1 0 3 3 3 1 PQQ-like domain PQQ PF01011.21 ETS64093.1 - 2.8e-05 23.8 0.0 0.0003 20.5 0.0 2.5 2 0 0 2 2 2 1 PQQ enzyme repeat Pkinase_fungal PF17667.1 ETS64093.1 - 0.00016 20.6 0.0 0.00016 20.6 0.0 2.8 3 1 0 3 3 2 1 Fungal protein kinase Kdo PF06293.14 ETS64093.1 - 0.0018 17.7 0.0 0.0033 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family UIM PF02809.20 ETS64093.1 - 0.011 15.6 0.5 0.047 13.6 0.5 2.2 1 0 0 1 1 1 0 Ubiquitin interaction motif APH PF01636.23 ETS64093.1 - 0.057 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ETS64093.1 - 0.18 11.3 0.0 0.35 10.3 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PQQ_3 PF13570.6 ETS64093.1 - 0.26 11.8 2.0 9.4 6.9 0.1 3.6 3 0 0 3 3 3 0 PQQ-like domain TMEM119 PF15724.5 ETS64093.1 - 6.4 6.8 27.7 0.023 14.8 14.9 2.8 2 1 0 2 2 2 0 TMEM119 family RTC PF01137.21 ETS64094.1 - 2.4e-49 167.5 0.0 3e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ETS64094.1 - 1.1e-34 119.0 0.0 2e-34 118.2 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain HTH_13 PF11972.8 ETS64094.1 - 0.12 12.4 0.3 1.2 9.3 0.0 2.7 4 0 0 4 4 4 0 HTH DNA binding domain BPL_N PF09825.9 ETS64095.1 - 6.8e-112 374.3 0.0 9e-112 373.9 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 ETS64095.1 - 1.9e-17 63.4 0.0 3.7e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 ETS64095.1 - 0.084 12.8 0.0 0.25 11.2 0.0 1.8 1 1 0 1 1 1 0 Biotin protein ligase C terminal domain Glyco_hydro_42M PF08532.10 ETS64095.1 - 0.13 11.7 0.1 8.3 5.9 0.0 3.0 3 0 0 3 3 3 0 Beta-galactosidase trimerisation domain ArsA_ATPase PF02374.15 ETS64096.1 - 8.4e-112 373.3 0.3 9.7e-112 373.1 0.3 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 ETS64096.1 - 9.1e-13 48.5 0.1 3.1e-12 46.8 0.0 1.9 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 ETS64096.1 - 2.5e-12 46.9 0.0 6.1e-12 45.7 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ETS64096.1 - 1.6e-05 24.5 4.7 0.00046 19.7 1.5 2.8 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 ETS64096.1 - 1.8e-05 24.4 0.0 5.9e-05 22.7 0.0 1.8 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 ETS64096.1 - 4.7e-05 23.0 0.1 0.00014 21.4 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 ETS64096.1 - 4.9e-05 23.1 0.2 0.00062 19.5 0.1 2.4 1 1 1 2 2 2 1 SRP54-type protein, GTPase domain PhoH PF02562.16 ETS64096.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein YabA PF06156.13 ETS64096.1 - 0.037 14.7 1.0 0.12 13.1 1.0 1.9 1 0 0 1 1 1 0 Initiation control protein YabA AAA_24 PF13479.6 ETS64096.1 - 0.052 13.3 0.0 0.15 11.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ETS64096.1 - 0.071 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_25 PF13481.6 ETS64096.1 - 0.082 12.5 1.3 1.3 8.5 1.3 2.4 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETS64096.1 - 0.089 13.3 0.0 1.5 9.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain KH_1 PF00013.29 ETS64097.1 - 1.7e-34 117.4 0.8 5.6e-08 32.5 0.0 6.9 7 0 0 7 7 7 5 KH domain Erf4 PF10256.9 ETS64097.1 - 2.4e-31 108.2 0.1 1.9e-30 105.3 0.0 2.3 2 0 0 2 2 2 1 Golgin subfamily A member 7/ERF4 family RNA_pol_Rpb5_C PF01191.19 ETS64097.1 - 8.1e-31 105.7 0.1 1.8e-30 104.6 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 ETS64097.1 - 1e-26 93.3 0.3 2.3e-26 92.2 0.3 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 ETS64097.1 - 0.0016 18.4 0.0 0.0045 17.0 0.0 1.7 1 0 0 1 1 1 1 Restriction endonuclease SRR1 PF07985.12 ETS64098.1 - 2.4e-16 59.5 0.9 8.1e-16 57.8 0.9 1.9 1 1 0 1 1 1 1 SRR1 Nse4_C PF08743.10 ETS64099.1 - 3.2e-25 88.2 0.0 6.7e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 ETS64099.1 - 1.8e-14 53.5 1.2 1.8e-14 53.5 1.2 2.1 2 0 0 2 2 2 1 Binding domain of Nse4/EID3 to Nse3-MAGE Ras PF00071.22 ETS64100.1 - 2.8e-41 140.8 0.5 3.7e-41 140.4 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS64100.1 - 1.1e-17 64.3 0.3 2.5e-17 63.2 0.1 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS64100.1 - 6.1e-10 38.8 0.1 7.4e-10 38.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETS64100.1 - 0.0038 16.8 0.1 0.0079 15.8 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETS64100.1 - 0.0072 16.3 0.5 0.01 15.8 0.5 1.4 1 1 0 1 1 1 1 RsgA GTPase DUF3873 PF12989.7 ETS64100.1 - 0.026 14.9 0.1 0.048 14.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) IDO PF01231.18 ETS64101.1 - 1.7e-144 481.8 0.0 2.2e-144 481.5 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase ACPS PF01648.20 ETS64101.1 - 7.5e-10 38.9 0.0 1.9e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily DUF974 PF06159.13 ETS64102.1 - 6e-66 222.7 0.0 8.2e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF974) Glyco_hydro_5_C PF18564.1 ETS64103.1 - 1.3e-20 73.7 0.7 3.1e-20 72.5 0.7 1.7 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 ETS64103.1 - 2.2e-11 43.7 0.0 2.7e-06 27.0 0.0 2.4 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Tocopherol_cycl PF14249.6 ETS64104.1 - 0.00022 20.5 0.0 0.0005 19.3 0.0 1.5 2 0 0 2 2 2 1 Tocopherol cyclase SR-25 PF10500.9 ETS64104.1 - 8.2 6.0 20.5 15 5.1 20.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Fcf1 PF04900.12 ETS64106.1 - 5.5e-28 97.3 1.0 1.1e-27 96.4 1.0 1.5 1 0 0 1 1 1 1 Fcf1 DUF4787 PF16029.5 ETS64106.1 - 0.073 13.2 0.2 0.18 11.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) TAF4 PF05236.14 ETS64106.1 - 1.2 8.9 15.9 1.7 8.3 15.9 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Dynactin PF12455.8 ETS64107.1 - 2.9e-76 256.4 1.4 2.9e-76 256.4 1.4 3.9 4 0 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.25 ETS64107.1 - 3.4e-22 78.2 1.1 7.5e-22 77.1 0.7 1.8 2 0 0 2 2 2 1 CAP-Gly domain UCR_TM PF02921.14 ETS64108.1 - 5e-11 42.9 0.6 5e-11 42.9 0.6 2.0 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region Rieske PF00355.26 ETS64108.1 - 2.9e-10 39.9 0.0 5.2e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Senescence_reg PF04520.13 ETS64108.1 - 0.16 12.8 2.1 10 6.9 0.1 2.3 1 1 1 2 2 2 0 Senescence regulator SOR_SNZ PF01680.17 ETS64109.1 - 7e-110 365.7 5.7 9.3e-110 365.3 5.7 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 ETS64109.1 - 3.6e-06 26.5 9.3 7.7e-06 25.4 0.2 2.8 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG TetR_C_27 PF17935.1 ETS64109.1 - 0.0032 17.5 0.0 0.025 14.6 0.0 2.2 2 0 0 2 2 2 1 Tetracyclin repressor-like, C-terminal domain NanE PF04131.14 ETS64109.1 - 0.0072 15.5 0.3 0.099 11.8 0.0 2.5 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 ETS64109.1 - 0.015 14.5 0.0 0.18 10.9 0.0 2.2 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase Dus PF01207.17 ETS64109.1 - 0.043 12.9 0.3 0.56 9.2 0.0 2.3 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Clathrin PF00637.20 ETS64113.1 - 9.5e-13 48.2 0.0 0.00049 20.0 0.0 3.3 3 0 0 3 3 3 3 Region in Clathrin and VPS zf-C3H2C3 PF17122.5 ETS64113.1 - 3.1e-09 36.7 6.7 5.6e-09 35.9 6.7 1.4 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 ETS64113.1 - 0.0011 18.8 7.2 0.0019 18.0 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Mito_carr PF00153.27 ETS64113.1 - 0.0029 17.5 0.1 0.023 14.6 0.0 2.7 3 0 0 3 3 3 1 Mitochondrial carrier protein zf-RING_5 PF14634.6 ETS64113.1 - 0.018 15.0 6.2 0.031 14.3 6.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 ETS64113.1 - 0.12 12.6 4.3 0.26 11.6 4.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETS64113.1 - 0.2 12.0 6.3 0.37 11.2 6.3 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 ETS64113.1 - 0.78 9.8 3.7 1.6 8.8 3.7 1.5 1 0 0 1 1 1 0 RING-type zinc-finger JTB PF05439.12 ETS64114.1 - 0.0013 18.7 3.1 0.004 17.2 3.1 1.8 1 1 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) RNA12 PF10443.9 ETS64116.1 - 1.2e-145 485.7 1.5 1.5e-145 485.4 1.5 1.1 1 0 0 1 1 1 1 RNA12 protein RRM_1 PF00076.22 ETS64116.1 - 5e-06 26.2 0.0 3.8e-05 23.4 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATPase_2 PF01637.18 ETS64116.1 - 6.9e-05 22.9 0.1 0.00038 20.5 0.0 2.1 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETS64116.1 - 0.0059 17.0 0.3 0.031 14.7 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ETS64116.1 - 0.0099 15.9 0.0 0.027 14.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF2487 PF10673.9 ETS64116.1 - 0.025 14.6 0.0 0.17 11.9 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2487) NB-ARC PF00931.22 ETS64116.1 - 0.13 11.5 0.0 0.25 10.5 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain tRNA-synt_2b PF00587.25 ETS64117.1 - 6.6e-39 133.7 0.0 9.8e-39 133.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ETS64117.1 - 1.2e-11 44.5 0.0 3.9e-11 42.9 0.0 1.8 1 1 0 1 1 1 1 Anticodon binding domain Nic96 PF04097.14 ETS64118.1 - 6e-184 613.0 0.4 7.7e-184 612.6 0.4 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Cation_efflux PF01545.21 ETS64118.1 - 3.5e-20 72.6 5.9 6.3e-20 71.7 5.9 1.5 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETS64118.1 - 3.7e-09 36.6 0.8 1.7e-08 34.5 0.0 2.4 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter Na_H_Exchanger PF00999.21 ETS64119.1 - 7.5e-66 222.5 36.3 7.5e-66 222.5 36.3 1.5 2 0 0 2 2 2 1 Sodium/hydrogen exchanger family SpoVAB PF13782.6 ETS64119.1 - 0.062 13.6 0.3 0.062 13.6 0.3 3.4 4 1 0 4 4 4 0 Stage V sporulation protein AB Glucosamine_iso PF01182.20 ETS64120.1 - 6.2e-75 251.9 0.0 7.7e-75 251.6 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Ras PF00071.22 ETS64121.1 - 5.3e-32 110.7 0.0 8e-30 103.6 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETS64121.1 - 1.7e-27 96.0 0.0 3.3e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS64121.1 - 2e-06 27.4 0.0 4.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS64121.1 - 0.00014 21.9 0.0 0.00031 20.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETS64121.1 - 0.00069 19.0 0.0 0.0011 18.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETS64121.1 - 0.0018 17.8 0.0 0.017 14.7 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETS64121.1 - 0.12 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit PIP5K PF01504.18 ETS64122.1 - 1.1e-98 329.8 0.0 2.6e-98 328.6 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Ribosomal_L28 PF00830.19 ETS64122.1 - 0.065 13.4 0.0 0.19 11.9 0.0 1.8 1 0 0 1 1 1 0 Ribosomal L28 family CENP-H PF05837.12 ETS64123.1 - 2.1e-11 44.2 6.4 2.1e-11 44.2 6.4 2.4 2 0 0 2 2 2 1 Centromere protein H (CENP-H) DUF5375 PF17345.2 ETS64123.1 - 0.07 13.0 0.1 0.2 11.6 0.0 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5375) TFIIA PF03153.13 ETS64123.1 - 0.34 10.8 11.8 0.48 10.4 11.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 ETS64123.1 - 8.9 5.5 11.2 14 4.9 11.2 1.3 1 0 0 1 1 1 0 NOA36 protein Thaumatin PF00314.17 ETS64124.1 - 0.0049 16.5 0.0 0.0081 15.8 0.0 1.4 1 0 0 1 1 1 1 Thaumatin family Avl9 PF09794.9 ETS64126.1 - 1.1e-139 465.4 0.0 1.4e-139 465.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 ETS64126.1 - 1.4e-10 41.3 0.0 0.0003 20.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 ETS64126.1 - 4.8e-09 36.2 0.0 3e-05 24.0 0.0 2.4 2 0 0 2 2 2 2 Stabilization of polarity axis Afi1 PF07792.12 ETS64126.1 - 1.1e-05 26.0 0.4 2.8e-05 24.6 0.0 1.8 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Fibrillarin PF01269.17 ETS64127.1 - 5.3e-105 349.6 0.0 6.5e-105 349.3 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 ETS64127.1 - 6.8e-06 25.9 0.0 9.7e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 ETS64127.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ETS64127.1 - 0.057 13.5 0.0 0.074 13.2 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 ETS64127.1 - 0.064 13.0 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Tubulin PF00091.25 ETS64128.1 - 1.3e-69 234.3 0.0 1.9e-69 233.8 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETS64128.1 - 2.9e-43 147.0 0.0 5.8e-43 146.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETS64128.1 - 1.6e-06 28.4 0.0 3e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ETS64128.1 - 0.0059 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain DEAD_2 PF06733.15 ETS64128.1 - 0.21 11.2 0.0 0.38 10.4 0.0 1.3 1 0 0 1 1 1 0 DEAD_2 TAF PF02969.17 ETS64129.1 - 7.2e-27 93.4 0.5 1.3e-26 92.5 0.5 1.5 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TAF6_C PF07571.13 ETS64129.1 - 5.7e-14 52.2 0.0 1.2e-13 51.2 0.0 1.5 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain Histone PF00125.24 ETS64129.1 - 5.7e-05 23.5 0.5 0.00012 22.5 0.5 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 ETS64129.1 - 0.0011 19.1 0.0 0.0023 18.0 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit LSM PF01423.22 ETS64130.1 - 5.5e-14 51.6 0.0 7e-14 51.3 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ETS64130.1 - 0.001 19.2 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 ETS64130.1 - 0.097 12.8 0.1 0.13 12.4 0.1 1.4 1 1 0 1 1 1 0 RimP C-terminal SH3 domain tRNA-synt_1b PF00579.25 ETS64131.1 - 1.2e-20 74.0 0.0 7.5e-20 71.4 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) PepSY_2 PF13670.6 ETS64131.1 - 0.073 13.1 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF3860 PF12976.7 ETS64131.1 - 0.16 12.0 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) Pkinase PF00069.25 ETS64133.1 - 3.2e-42 144.7 0.1 4.2e-21 75.5 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64133.1 - 1.5e-10 40.8 0.2 5.6e-08 32.4 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase RIO1 PF01163.22 ETS64133.1 - 0.25 10.9 0.1 0.42 10.2 0.1 1.3 1 0 0 1 1 1 0 RIO1 family BRCT PF00533.26 ETS64135.1 - 0.016 15.5 0.0 0.041 14.3 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain BRCT_3 PF18428.1 ETS64135.1 - 0.084 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ETS64135.1 - 0.085 13.3 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain SAGA-Tad1 PF12767.7 ETS64136.1 - 2.2e-45 155.2 0.0 4.1e-45 154.3 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Mcl1_mid PF12341.8 ETS64137.1 - 6.6e-83 278.5 0.0 4.6e-81 272.4 0.0 2.6 3 0 0 3 3 3 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 ETS64137.1 - 1.1e-13 51.4 4.5 0.00042 21.1 0.0 6.3 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64137.1 - 4.6e-10 39.7 0.0 4.4e-05 23.7 0.0 4.6 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain R3H PF01424.22 ETS64138.1 - 2.4e-15 56.3 0.0 4e-15 55.5 0.0 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 ETS64138.1 - 7.7e-07 29.0 35.6 1.6e-05 24.9 14.3 14.4 15 1 0 15 15 15 5 NF-X1 type zinc finger FancD2 PF14631.6 ETS64138.1 - 4.5 4.5 4.0 6.1 4.1 4.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease COesterase PF00135.28 ETS64139.1 - 0.0039 16.1 0.0 0.007 15.3 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ETS64139.1 - 0.0089 15.5 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ETS64139.1 - 0.02 14.8 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS64139.1 - 0.025 13.8 0.0 0.059 12.6 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 TelA PF05816.11 ETS64140.1 - 0.0098 15.0 2.8 0.015 14.4 2.8 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) IFT57 PF10498.9 ETS64140.1 - 0.17 10.8 2.8 0.41 9.6 2.8 1.6 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1640 PF07798.11 ETS64140.1 - 0.19 11.8 3.8 0.38 10.8 3.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) MTCP1 PF08991.10 ETS64141.1 - 5.2e-24 84.2 3.7 7.6e-24 83.7 3.7 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type CHCH PF06747.13 ETS64141.1 - 1.7 8.9 5.3 2.9 8.1 5.3 1.5 1 0 0 1 1 1 0 CHCH domain Med26 PF08711.11 ETS64142.1 - 9.2e-09 35.2 0.0 4.2e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain DUF5560 PF17715.1 ETS64142.1 - 0.2 11.1 5.1 0.75 9.2 0.0 3.3 3 1 1 4 4 4 0 Family of unknown function (DUF5560) Sulfate_transp PF00916.20 ETS64143.1 - 4.5e-59 200.1 18.0 6.9e-59 199.5 18.0 1.2 1 0 0 1 1 1 1 Sulfate permease family cNMP_binding PF00027.29 ETS64143.1 - 1.7e-13 50.4 0.0 4.6e-13 49.0 0.0 1.8 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 ETS64143.1 - 4e-08 32.9 0.0 7.7e-08 32.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain Striatin PF08232.12 ETS64144.1 - 2.9e-51 174.1 0.0 2.9e-51 174.1 0.0 3.3 2 1 0 2 2 2 1 Striatin family WD40 PF00400.32 ETS64144.1 - 5e-36 122.1 4.5 1.2e-06 29.1 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64144.1 - 5.7e-06 26.5 0.0 2.8 8.3 0.0 5.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETS64144.1 - 0.0043 15.8 0.0 4.6 5.9 0.0 3.3 3 0 0 3 3 3 1 Nup133 N terminal like PAN_3 PF08277.12 ETS64144.1 - 0.0045 16.8 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 PAN-like domain NICE-1 PF15845.5 ETS64144.1 - 0.031 15.1 1.7 0.031 15.1 1.7 4.6 5 1 0 5 5 5 0 Cysteine-rich C-terminal 1 family BTB PF00651.31 ETS64145.1 - 4.8e-10 39.7 0.3 0.0003 21.0 0.0 3.6 3 1 0 3 3 3 3 BTB/POZ domain MATH PF00917.26 ETS64145.1 - 0.03 14.5 0.6 0.21 11.7 0.2 2.2 1 1 1 2 2 2 0 MATH domain SLX9 PF15341.6 ETS64145.1 - 0.075 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 NCBP3 PF10309.9 ETS64146.1 - 5.7e-14 51.7 0.0 8.9e-14 51.1 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 MRP-L20 PF12824.7 ETS64146.1 - 0.032 14.4 1.6 0.032 14.4 1.6 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit L20 DUF4238 PF14022.6 ETS64146.1 - 0.045 13.3 0.5 0.066 12.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4238) R3H PF01424.22 ETS64147.1 - 2.3e-09 37.1 0.1 5.8e-09 35.8 0.1 1.7 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 ETS64147.1 - 9.2e-08 31.8 0.1 2.7e-07 30.3 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mur_ligase_M PF08245.12 ETS64147.1 - 7.7e-05 22.8 0.0 0.0014 18.7 0.0 2.8 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ETS64147.1 - 0.094 13.0 0.0 0.31 11.3 0.0 1.9 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain Cyclase PF04199.13 ETS64148.1 - 7.4e-14 52.2 0.0 1.8e-13 50.9 0.0 1.7 1 1 0 1 1 1 1 Putative cyclase Perilipin PF03036.16 ETS64148.1 - 0.0011 18.1 1.1 0.0016 17.5 1.1 1.2 1 0 0 1 1 1 1 Perilipin family ABC_tran PF00005.27 ETS64149.1 - 1.4e-46 158.4 0.2 1.3e-21 77.6 0.0 3.3 3 1 0 3 3 2 2 ABC transporter ABC_tran_Xtn PF12848.7 ETS64149.1 - 2.5e-25 88.3 4.0 2.5e-25 88.3 4.0 3.7 4 0 0 4 4 3 1 ABC transporter AAA_21 PF13304.6 ETS64149.1 - 2.2e-17 63.8 0.1 0.00036 20.4 0.0 4.4 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETS64149.1 - 3.7e-11 42.9 0.2 0.0012 18.4 0.0 4.3 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS64149.1 - 1.6e-07 31.0 0.5 0.0077 16.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ETS64149.1 - 3.6e-07 30.2 0.2 0.039 14.0 0.0 3.5 3 0 0 3 3 3 2 50S ribosome-binding GTPase AAA_22 PF13401.6 ETS64149.1 - 3.1e-06 27.5 0.6 0.15 12.3 0.1 4.1 4 1 0 4 4 3 2 AAA domain AAA_18 PF13238.6 ETS64149.1 - 4.6e-06 27.2 0.1 0.99 10.0 0.0 3.7 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 ETS64149.1 - 6.7e-06 26.1 0.1 0.084 12.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ETS64149.1 - 1.1e-05 25.9 2.9 0.14 12.5 0.6 3.2 3 0 0 3 3 3 2 AAA ATPase domain NACHT PF05729.12 ETS64149.1 - 1.1e-05 25.4 0.2 0.014 15.3 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_25 PF13481.6 ETS64149.1 - 0.0003 20.4 0.3 1.1 8.8 0.1 3.3 4 0 0 4 4 3 2 AAA domain AAA PF00004.29 ETS64149.1 - 0.0003 21.2 0.0 0.29 11.6 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETS64149.1 - 0.00039 20.0 0.1 0.73 9.3 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 ETS64149.1 - 0.00061 19.6 0.0 1 9.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ETS64149.1 - 0.00063 20.1 0.0 0.32 11.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_15 PF13175.6 ETS64149.1 - 0.0027 17.5 6.9 0.93 9.1 0.0 3.7 2 1 1 3 3 3 2 AAA ATPase domain AAA_14 PF13173.6 ETS64149.1 - 0.0028 17.7 0.0 3.9 7.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 ETS64149.1 - 0.005 15.9 0.1 1.4 7.8 0.0 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 ETS64149.1 - 0.0072 16.6 7.8 0.32 11.2 0.4 3.2 3 0 0 3 3 3 2 AAA domain Roc PF08477.13 ETS64149.1 - 0.0093 16.2 0.0 5.5 7.2 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 ETS64149.1 - 0.01 15.0 0.1 3.2 6.9 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain cobW PF02492.19 ETS64149.1 - 0.019 14.5 0.0 7 6.2 0.0 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.17 ETS64149.1 - 0.026 14.6 4.4 0.13 12.3 0.0 3.4 4 0 0 4 4 4 0 Helicase HerA, central domain NTPase_1 PF03266.15 ETS64149.1 - 0.05 13.5 0.0 6.9 6.5 0.0 2.7 2 0 0 2 2 2 0 NTPase IstB_IS21 PF01695.17 ETS64149.1 - 0.05 13.3 0.0 7.9 6.2 0.0 2.9 3 0 0 3 3 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 ETS64149.1 - 0.079 13.5 0.0 0.079 13.5 0.0 4.8 4 1 0 5 5 4 0 AAA domain AAA_33 PF13671.6 ETS64149.1 - 0.082 13.1 11.2 0.46 10.6 0.0 3.7 4 1 0 4 4 3 0 AAA domain ATP_bind_1 PF03029.17 ETS64149.1 - 0.13 12.0 0.0 3.1 7.5 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 ETS64149.1 - 0.16 12.0 3.6 1 9.4 0.0 3.2 4 0 0 4 4 3 0 Dynamin family ATP-synt_ab PF00006.25 ETS64149.1 - 0.16 11.6 0.3 1.2 8.7 0.1 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_27 PF13514.6 ETS64149.1 - 0.28 10.8 4.6 0.6 9.7 0.0 3.2 3 1 1 4 4 3 0 AAA domain Pilt PF15453.6 ETS64149.1 - 0.64 9.4 5.8 0.078 12.4 1.7 1.5 2 0 0 2 2 1 0 Protein incorporated later into Tight Junctions AAA_5 PF07728.14 ETS64149.1 - 1.1 9.3 5.2 19 5.3 0.0 3.6 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) DUF4391 PF14335.6 ETS64149.1 - 4.2 7.0 10.0 1.8 8.2 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4391) NAD_binding_1 PF00175.21 ETS64150.1 - 3.9e-26 91.8 0.0 1.3e-25 90.2 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ETS64150.1 - 1.2e-19 70.4 0.0 2.4e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ETS64150.1 - 7.1e-05 23.0 0.0 0.0005 20.2 0.0 2.0 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ETS64150.1 - 0.19 12.0 0.0 0.47 10.7 0.0 1.7 2 0 0 2 2 2 0 Siderophore-interacting FAD-binding domain UCH PF00443.29 ETS64152.1 - 1.1e-40 139.8 0.0 1.7e-40 139.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS64152.1 - 6.3e-07 29.3 0.0 0.0035 17.0 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase SUZ PF12752.7 ETS64153.1 - 4.9e-15 56.0 7.1 4.9e-15 56.0 7.1 5.6 4 2 1 5 5 5 1 SUZ domain R3H PF01424.22 ETS64153.1 - 2.7e-09 36.9 0.8 5.8e-09 35.8 0.8 1.6 1 0 0 1 1 1 1 R3H domain Glyco_transf_8 PF01501.20 ETS64154.1 - 7.6e-05 22.4 0.5 0.00071 19.2 0.5 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 8 Acyl-CoA_dh_1 PF00441.24 ETS64155.1 - 1.8e-32 112.6 1.8 2.6e-32 112.1 1.8 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETS64155.1 - 5.8e-18 64.9 0.1 1e-17 64.1 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ETS64155.1 - 4.2e-12 46.7 0.0 2.3e-11 44.3 0.0 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ETS64155.1 - 7.5e-10 39.2 0.7 1.1e-09 38.6 0.7 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain DEAD PF00270.29 ETS64156.1 - 9.5e-47 159.0 0.0 1.9e-46 158.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS64156.1 - 1.7e-27 95.9 0.0 6.5e-26 90.9 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS64156.1 - 6.1e-06 26.4 0.1 3.3e-05 24.0 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2986 PF11661.8 ETS64156.1 - 0.0055 17.2 1.6 0.021 15.3 1.6 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2986) CMS1 PF14617.6 ETS64156.1 - 1.1 8.6 7.8 1.5 8.1 0.0 2.4 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Rrp15p PF07890.12 ETS64156.1 - 2.1 8.7 13.9 6.5 7.1 13.9 1.8 1 0 0 1 1 1 0 Rrp15p CCDC106 PF15794.5 ETS64157.1 - 0.14 11.8 2.3 0.19 11.4 0.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Ras PF00071.22 ETS64158.1 - 1e-53 181.3 0.0 1.2e-53 181.0 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS64158.1 - 2.8e-21 75.9 0.0 1.2e-20 73.9 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS64158.1 - 4.9e-07 29.4 0.0 9.4e-07 28.4 0.0 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 ETS64158.1 - 0.19 11.2 0.0 0.36 10.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 ETS64158.1 - 0.2 11.4 0.3 2.2 8.0 0.3 2.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 ETS64158.1 - 0.23 10.8 0.0 0.33 10.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ssu72 PF04722.13 ETS64159.1 - 1.3e-80 269.5 0.0 1.5e-80 269.3 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein LMWPc PF01451.21 ETS64159.1 - 0.16 12.4 0.4 0.63 10.4 0.2 1.9 2 0 0 2 2 2 0 Low molecular weight phosphotyrosine protein phosphatase DNA_pol_viral_N PF00242.17 ETS64160.1 - 0.085 12.3 3.4 0.07 12.6 1.6 1.6 1 1 1 2 2 2 0 DNA polymerase (viral) N-terminal domain Gcd10p PF04189.13 ETS64161.1 - 7e-77 258.5 0.0 1.3e-76 257.6 0.0 1.4 1 0 0 1 1 1 1 Gcd10p family PDDEXK_2 PF12784.7 ETS64161.1 - 0.11 12.0 0.1 0.2 11.2 0.1 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase DUF5572 PF17733.1 ETS64162.1 - 1.6e-19 69.5 1.9 1.6e-19 69.5 1.9 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5572) CDC27 PF09507.10 ETS64163.1 - 1.5e-88 298.0 53.6 4.6e-87 293.2 53.6 2.2 1 1 0 1 1 1 1 DNA polymerase subunit Cdc27 DBD_HTH PF18430.1 ETS64163.1 - 0.052 13.3 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Putative DNA-binding domain Pyr_redox_2 PF07992.14 ETS64164.1 - 2.5e-52 177.9 0.1 1.4e-51 175.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DEAD PF00270.29 ETS64164.1 - 5.3e-33 114.2 0.3 1.4e-32 112.9 0.3 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS64164.1 - 1.1e-28 99.8 0.2 2.7e-28 98.5 0.2 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Pyr_redox PF00070.27 ETS64164.1 - 1.9e-18 66.8 0.5 2.9e-15 56.6 0.1 3.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETS64164.1 - 1.3e-17 64.1 0.2 4e-14 52.6 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETS64164.1 - 5.4e-05 22.5 0.1 0.00048 19.4 0.1 2.4 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 ETS64164.1 - 0.0001 22.5 0.1 0.0044 17.2 0.0 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ETS64164.1 - 0.00017 21.1 0.4 0.03 13.7 0.0 2.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETS64164.1 - 0.00067 18.8 0.6 0.025 13.7 0.1 2.3 2 0 0 2 2 2 1 FAD binding domain AAA_30 PF13604.6 ETS64164.1 - 0.0011 18.7 0.1 0.0047 16.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain DAO PF01266.24 ETS64164.1 - 0.0022 17.7 0.0 0.013 15.1 0.0 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase K_oxygenase PF13434.6 ETS64164.1 - 0.0024 17.1 0.3 0.1 11.7 0.0 2.8 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 ETS64164.1 - 0.011 16.1 0.8 0.3 11.5 0.0 3.2 3 0 0 3 3 3 0 Putative NAD(P)-binding HI0933_like PF03486.14 ETS64164.1 - 0.015 14.1 0.3 0.042 12.5 0.2 1.9 2 0 0 2 2 2 0 HI0933-like protein GIDA PF01134.22 ETS64164.1 - 0.02 14.0 5.9 0.022 13.9 0.1 3.1 4 0 0 4 4 4 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 ETS64164.1 - 0.024 13.5 0.0 0.17 10.7 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase FAD_binding_3 PF01494.19 ETS64164.1 - 0.024 13.9 0.4 0.11 11.7 0.1 2.2 2 0 0 2 2 2 0 FAD binding domain WD40 PF00400.32 ETS64165.1 - 1.6e-20 73.0 4.1 0.00078 20.2 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64165.1 - 2.1e-09 37.6 0.0 1.1e-06 28.8 0.0 3.7 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS64165.1 - 0.0065 15.5 0.1 0.12 11.3 0.0 2.6 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Gcd10p PF04189.13 ETS64165.1 - 0.043 12.9 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 Gcd10p family MMS1_N PF10433.9 ETS64165.1 - 0.14 10.8 0.0 0.41 9.2 0.0 1.7 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Aldedh PF00171.22 ETS64166.1 - 9.1e-121 403.6 0.0 1.1e-120 403.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3813 PF12758.7 ETS64166.1 - 0.17 12.2 0.1 0.5 10.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3813) DSPc PF00782.20 ETS64167.1 - 0.00026 20.8 0.0 0.00051 19.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ETS64167.1 - 0.00028 21.0 0.1 0.0014 18.7 0.0 2.1 2 1 1 3 3 3 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ETS64167.1 - 0.018 15.0 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 ETS64167.1 - 0.082 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase JAB PF01398.21 ETS64168.1 - 9.1e-31 106.3 0.3 2.7e-30 104.8 0.1 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 ETS64168.1 - 4.2e-19 69.2 0.2 8.1e-19 68.3 0.2 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 ETS64168.1 - 3.6e-05 23.5 0.0 7.4e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 ETS64168.1 - 0.062 13.3 0.3 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) Cyclin_N PF00134.23 ETS64169.1 - 2.3e-45 153.4 0.5 1.6e-43 147.5 0.1 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETS64169.1 - 3e-33 114.4 0.2 5.6e-33 113.6 0.2 1.5 1 0 0 1 1 1 1 Cyclin, C-terminal domain UvrD-helicase PF00580.21 ETS64171.1 - 1.5e-14 54.2 0.0 7.9e-11 42.0 0.0 2.4 2 0 0 2 2 2 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ETS64171.1 - 3.5e-14 52.9 0.0 6.6e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ETS64171.1 - 3.8e-12 46.8 0.0 7.6e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 ETS64171.1 - 3.1e-11 42.9 0.7 2.6e-10 40.0 0.7 2.6 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 ETS64171.1 - 1.5e-08 34.6 0.2 0.086 12.6 0.0 3.6 3 1 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ETS64171.1 - 3.2e-06 27.0 4.9 0.011 15.5 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ETS64171.1 - 0.0003 21.1 0.0 0.61 10.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 ETS64171.1 - 0.0016 17.9 0.0 0.084 12.3 0.0 2.7 3 0 0 3 3 3 1 PhoH-like protein AAA_12 PF13087.6 ETS64171.1 - 0.0092 15.6 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain BolA PF01722.18 ETS64172.1 - 1.8e-18 66.5 0.1 3.1e-18 65.8 0.1 1.4 1 0 0 1 1 1 1 BolA-like protein CN_hydrolase PF00795.22 ETS64173.1 - 3.5e-11 43.0 0.0 9.2e-10 38.3 0.0 2.4 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Actin PF00022.19 ETS64177.1 - 5.8e-35 120.7 0.0 1.3e-34 119.5 0.0 1.5 1 1 0 1 1 1 1 Actin CHCH PF06747.13 ETS64178.1 - 6.7e-09 35.7 3.4 9.3e-09 35.2 3.4 1.2 1 0 0 1 1 1 1 CHCH domain NDUF_B7 PF05676.13 ETS64178.1 - 0.0046 16.6 1.3 0.0063 16.2 1.3 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 ETS64178.1 - 0.009 16.3 4.3 0.035 14.4 4.2 1.8 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 ETS64178.1 - 0.0096 15.9 3.6 0.015 15.3 3.6 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 ETS64178.1 - 0.11 12.6 3.7 0.73 9.9 3.9 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 ETS64178.1 - 0.12 12.8 5.6 1.3 9.4 1.0 2.4 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 ETS64178.1 - 0.14 12.5 2.6 0.65 10.3 0.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) zf-MYND PF01753.18 ETS64179.1 - 1.4e-10 41.1 10.9 1.4e-10 41.1 10.9 3.4 3 1 0 3 3 3 1 MYND finger SET PF00856.28 ETS64179.1 - 5.8e-09 36.6 0.0 1.4e-08 35.4 0.0 1.8 1 1 0 1 1 1 1 SET domain zf-Mss51 PF13824.6 ETS64179.1 - 0.2 11.8 8.6 4 7.6 2.5 2.7 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 RNA_pol_3_Rpc31 PF11705.8 ETS64180.1 - 2.1e-05 24.9 5.5 3.8e-05 24.1 5.5 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Cnd1 PF12717.7 ETS64180.1 - 2.5e-05 24.4 7.7 0.022 14.8 0.1 5.9 4 3 2 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Ecm29 PF13001.7 ETS64180.1 - 0.00077 18.3 2.7 0.04 12.6 0.0 3.7 4 0 0 4 4 4 1 Proteasome stabiliser HEAT_2 PF13646.6 ETS64180.1 - 0.0012 19.1 3.3 0.028 14.8 0.2 7.0 6 2 1 8 8 8 2 HEAT repeats Anticodon_1 PF08264.13 ETS64180.1 - 0.014 15.3 0.1 0.055 13.4 0.1 2.0 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Pox_Ag35 PF03286.14 ETS64180.1 - 0.019 14.7 6.5 0.044 13.6 6.5 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein HEAT PF02985.22 ETS64180.1 - 0.029 14.6 10.8 20 5.8 0.5 6.0 6 0 0 6 6 5 0 HEAT repeat UNC45-central PF11701.8 ETS64180.1 - 0.31 11.0 2.6 12 5.9 0.3 3.7 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central NOA36 PF06524.12 ETS64180.1 - 0.69 9.2 11.8 1.2 8.4 11.8 1.3 1 0 0 1 1 1 0 NOA36 protein Acyl-CoA_dh_2 PF08028.11 ETS64180.1 - 3.1 8.1 8.8 19 5.6 2.7 3.4 3 0 0 3 3 2 0 Acyl-CoA dehydrogenase, C-terminal domain Cwf_Cwc_15 PF04889.12 ETS64180.1 - 4 7.1 15.9 0.66 9.7 11.8 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 ETS64180.1 - 5.6 7.4 15.7 17 5.9 15.7 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIF_alpha PF05793.12 ETS64180.1 - 5.6 5.4 18.9 10 4.6 18.9 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PHD PF00628.29 ETS64181.1 - 9e-07 28.7 14.2 1.5e-06 28.0 14.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETS64181.1 - 0.00062 19.3 6.0 0.0011 18.4 6.0 1.4 1 0 0 1 1 1 1 PHD-finger PfaD_N PF18328.1 ETS64181.1 - 0.11 12.4 1.8 0.46 10.5 1.8 2.1 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain Stc1 PF12898.7 ETS64181.1 - 0.4 11.2 4.3 1.2 9.8 4.3 1.8 1 0 0 1 1 1 0 Stc1 domain AMP-binding PF00501.28 ETS64182.1 - 2e-89 300.1 0.0 2.6e-89 299.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS64182.1 - 0.0011 19.8 0.1 0.0036 18.2 0.1 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain MRG PF05712.13 ETS64183.1 - 3.3e-60 202.8 0.0 4.6e-60 202.3 0.0 1.1 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 ETS64183.1 - 4.7e-10 39.2 0.1 1.1e-09 38.0 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 ETS64183.1 - 0.064 13.2 1.5 0.16 11.9 1.5 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Tht1 PF04163.12 ETS64184.1 - 0.46 9.2 3.1 0.39 9.4 0.1 2.0 2 1 0 2 2 2 0 Tht1-like nuclear fusion protein Septin PF00735.18 ETS64185.1 - 9.1e-123 409.0 0.8 1.5e-122 408.3 0.8 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ETS64185.1 - 7.7e-09 35.6 0.2 2.2e-08 34.2 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETS64185.1 - 7e-06 26.1 4.4 4.1e-05 23.6 0.1 2.8 3 1 0 3 3 2 1 RsgA GTPase Dynamin_N PF00350.23 ETS64185.1 - 7.7e-05 22.8 2.8 0.13 12.3 0.0 3.3 2 1 0 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 ETS64185.1 - 0.00021 20.9 3.5 0.0024 17.4 0.0 3.0 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain Ras PF00071.22 ETS64185.1 - 0.00039 20.1 1.4 0.0055 16.3 0.0 2.7 2 1 0 2 2 2 1 Ras family AAA_22 PF13401.6 ETS64185.1 - 0.0024 18.2 0.9 0.011 16.0 0.0 2.5 3 2 0 3 3 3 1 AAA domain AIG1 PF04548.16 ETS64185.1 - 0.0028 17.0 0.8 0.0062 15.9 0.0 2.0 2 0 0 2 2 2 1 AIG1 family ABC_tran PF00005.27 ETS64185.1 - 0.0076 16.8 8.4 0.024 15.1 1.4 2.6 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETS64185.1 - 0.012 15.3 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ETS64185.1 - 0.017 15.5 0.1 0.054 13.9 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 ETS64185.1 - 0.024 14.9 0.0 0.069 13.4 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Exonuc_VII_L PF02601.15 ETS64185.1 - 0.072 12.6 5.5 0.14 11.7 5.5 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit PduV-EutP PF10662.9 ETS64185.1 - 0.11 12.2 0.4 15 5.3 0.0 3.2 3 1 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 ETS64185.1 - 0.11 12.2 0.0 0.31 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ETS64185.1 - 0.29 10.9 4.7 0.42 10.4 2.7 2.1 2 0 0 2 2 2 0 AAA domain OmpH PF03938.14 ETS64185.1 - 0.44 10.9 9.7 0.95 9.8 9.7 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Atg14 PF10186.9 ETS64185.1 - 2.2 7.3 7.3 3.8 6.5 7.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATP_bind_1 PF03029.17 ETS64185.1 - 2.4 7.9 4.6 27 4.4 0.0 3.2 4 1 0 4 4 4 0 Conserved hypothetical ATP binding protein DUF4140 PF13600.6 ETS64185.1 - 7.6 7.0 7.9 3.2e+02 1.9 7.6 3.2 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) AdoHcyase PF05221.17 ETS64186.1 - 1.7e-133 444.4 0.0 2.4e-74 250.2 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ETS64186.1 - 1.5e-84 282.0 3.3 2.3e-84 281.4 3.3 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 ETS64186.1 - 3.2e-10 39.6 0.0 6.3e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ETS64186.1 - 0.00047 19.8 0.2 0.00074 19.1 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 ETS64186.1 - 0.0031 17.8 0.1 0.0066 16.7 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 ETS64186.1 - 0.053 14.0 0.1 0.16 12.4 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding THF_DHG_CYH_C PF02882.19 ETS64186.1 - 0.068 12.5 0.6 0.31 10.3 0.6 2.1 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 ETS64186.1 - 0.13 12.3 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Creatinase_N_2 PF16189.5 ETS64187.1 - 4.4e-47 160.2 0.0 8.6e-45 152.7 0.0 2.7 3 0 0 3 3 3 2 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ETS64187.1 - 1.4e-43 149.0 0.0 2.2e-43 148.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 ETS64187.1 - 5e-23 80.9 0.1 1.2e-22 79.8 0.1 1.6 1 0 0 1 1 1 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ETS64187.1 - 2.7e-21 76.6 0.0 8.5e-19 68.5 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain TPR_14 PF13428.6 ETS64189.1 - 2.8 9.0 14.4 5.8 8.0 1.4 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat IDO PF01231.18 ETS64190.1 - 1.5e-35 122.9 0.0 2.2e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Ank_5 PF13857.6 ETS64191.1 - 5.2e-18 64.9 2.5 1.8e-10 40.8 0.1 3.7 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS64191.1 - 7.7e-17 61.7 0.2 4.9e-12 46.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS64191.1 - 8.7e-17 61.3 0.5 8e-13 48.6 0.4 3.0 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ETS64191.1 - 2.6e-13 49.7 2.7 0.0002 21.7 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ETS64191.1 - 2.9e-12 45.6 2.2 0.0013 19.1 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Pro_isomerase PF00160.21 ETS64192.1 - 3.5e-48 163.8 0.1 4e-48 163.6 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD La PF05383.17 ETS64194.1 - 1.5e-23 82.6 0.0 1.2e-22 79.7 0.0 2.4 2 0 0 2 2 2 1 La domain RRM_1 PF00076.22 ETS64194.1 - 8.2e-08 32.0 0.4 2.7e-07 30.3 0.4 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETS64194.1 - 1e-05 25.5 0.2 0.00065 19.7 0.1 2.6 2 0 0 2 2 2 1 RNA binding motif adh_short PF00106.25 ETS64195.1 - 4.1e-29 101.4 0.2 5.2e-16 58.7 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS64195.1 - 4.6e-15 55.8 0.1 1.4e-08 34.6 0.3 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS64195.1 - 2.4e-12 47.2 0.4 4.1e-10 39.9 0.1 2.2 2 0 0 2 2 2 1 KR domain THF_DHG_CYH_C PF02882.19 ETS64195.1 - 1.5e-05 24.4 0.1 2.4e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 ETS64195.1 - 0.00047 20.1 0.3 0.00093 19.1 0.3 1.6 1 1 0 1 1 1 1 NAD(P)H-binding F420_oxidored PF03807.17 ETS64195.1 - 0.00069 20.1 0.2 0.0019 18.7 0.2 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 ETS64195.1 - 0.0011 18.9 0.2 0.0019 18.1 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain YjeF_N PF03853.15 ETS64195.1 - 0.0083 16.0 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus GDP_Man_Dehyd PF16363.5 ETS64195.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ETS64195.1 - 0.022 15.0 0.6 0.042 14.1 0.1 1.7 2 0 0 2 2 1 0 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 ETS64195.1 - 0.029 13.5 0.0 0.038 13.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Helicase_RecD PF05127.14 ETS64195.1 - 0.034 14.0 0.3 0.059 13.2 0.3 1.3 1 0 0 1 1 1 0 Helicase NAD_binding_2 PF03446.15 ETS64195.1 - 0.052 13.7 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Epimerase PF01370.21 ETS64195.1 - 0.059 12.8 0.0 0.12 11.8 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 ETS64195.1 - 0.072 13.1 0.3 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DFP PF04127.15 ETS64195.1 - 0.083 12.7 0.3 0.14 12.0 0.3 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein NAD_binding_7 PF13241.6 ETS64195.1 - 0.12 12.8 0.1 0.24 11.8 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Eno-Rase_NADH_b PF12242.8 ETS64195.1 - 0.14 11.9 0.4 0.34 10.7 0.2 1.8 1 1 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase COG2 PF06148.11 ETS64196.1 - 7.2e-16 58.5 2.9 5.6e-12 45.9 0.1 2.9 2 0 0 2 2 2 2 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 ETS64196.1 - 2.6e-07 31.0 0.0 8e-07 29.5 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) Vps51 PF08700.11 ETS64196.1 - 0.025 14.7 0.1 0.06 13.4 0.1 1.7 1 0 0 1 1 1 0 Vps51/Vps67 Helicase_PWI PF18149.1 ETS64196.1 - 0.087 13.0 0.1 0.79 9.9 0.0 2.5 2 0 0 2 2 2 0 N-terminal helicase PWI domain Tombus_movement PF05318.12 ETS64196.1 - 0.43 11.5 1.5 0.92 10.4 0.4 2.1 2 0 0 2 2 2 0 Tombusvirus movement protein DUF4404 PF14357.6 ETS64196.1 - 0.86 10.3 5.0 1.3 9.7 0.7 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Pkinase PF00069.25 ETS64197.1 - 1.8e-68 230.8 0.0 2.9e-68 230.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64197.1 - 3.4e-49 167.5 0.0 5.9e-49 166.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS64197.1 - 4.9e-05 22.3 0.4 0.00017 20.5 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ETS64197.1 - 0.026 13.9 0.0 0.09 12.1 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Haspin_kinase PF12330.8 ETS64197.1 - 0.065 12.2 0.0 5 6.0 0.0 2.2 2 0 0 2 2 2 0 Haspin like kinase domain GrpE PF01025.19 ETS64197.1 - 0.072 12.8 0.3 0.14 11.8 0.3 1.4 1 0 0 1 1 1 0 GrpE Mito_carr PF00153.27 ETS64198.1 - 2.8e-50 168.2 4.0 1.9e-17 63.0 0.3 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Lactococcin PF04369.13 ETS64198.1 - 0.027 14.6 0.4 11 6.2 0.0 3.3 3 0 0 3 3 3 0 Lactococcin-like family SURF4 PF02077.15 ETS64199.1 - 1.8e-93 313.0 4.7 2e-93 312.8 4.7 1.0 1 0 0 1 1 1 1 SURF4 family DUF5562 PF17717.1 ETS64199.1 - 0.096 12.7 2.0 0.11 12.4 0.7 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5562) HR_lesion PF05514.11 ETS64199.1 - 0.81 9.9 9.8 0.37 11.0 2.6 2.8 3 1 0 3 3 3 0 HR-like lesion-inducing Peptidase_M28 PF04389.17 ETS64201.1 - 1e-31 110.2 0.0 2e-31 109.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ETS64201.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Fungal_trans PF04082.18 ETS64202.1 - 3e-15 56.0 0.0 6.1e-15 55.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS64202.1 - 2.3e-07 30.8 8.9 4.4e-07 29.9 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_47 PF01532.20 ETS64203.1 - 2.5e-149 498.1 0.0 4.2e-149 497.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 TRAPPC-Trs85 PF12739.7 ETS64203.1 - 2.4e-111 372.6 0.0 4.8e-111 371.6 0.0 1.5 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Foie-gras_1 PF11817.8 ETS64203.1 - 0.012 15.3 1.1 0.025 14.2 1.1 1.5 1 0 0 1 1 1 0 Foie gras liver health family 1 GATA PF00320.27 ETS64205.1 - 1.5e-26 91.7 15.7 3.5e-14 52.1 3.9 2.4 2 0 0 2 2 2 2 GATA zinc finger DUF1752 PF08550.10 ETS64205.1 - 1.3e-09 37.7 0.9 2.7e-09 36.7 0.9 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TF_Zn_Ribbon PF08271.12 ETS64205.1 - 6.7e-05 22.3 3.5 0.098 12.2 0.5 2.5 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ETS64205.1 - 0.00027 21.0 0.7 1.1 9.5 0.1 2.5 2 0 0 2 2 2 2 Zinc ribbon domain eIF-5_eIF-2B PF01873.17 ETS64205.1 - 0.026 14.4 4.0 1.9 8.4 0.3 2.6 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Lar_restr_allev PF14354.6 ETS64205.1 - 0.09 13.2 0.7 4.7 7.7 0.0 2.8 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-Sec23_Sec24 PF04810.15 ETS64205.1 - 0.13 12.3 4.5 1 9.5 0.4 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Elf1 PF05129.13 ETS64205.1 - 0.14 12.2 0.3 8.2 6.5 0.0 2.8 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Auto_anti-p27 PF06677.12 ETS64205.1 - 0.54 10.5 6.2 2.9 8.1 0.8 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-RRN7 PF11781.8 ETS64205.1 - 0.58 9.9 4.9 0.35 10.6 1.1 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DZR PF12773.7 ETS64205.1 - 0.69 10.0 8.1 6.5 6.9 0.6 2.6 1 1 2 3 3 3 0 Double zinc ribbon DUF572 PF04502.13 ETS64207.1 - 1.4e-47 163.0 2.4 1.5e-47 162.8 2.4 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) SGL PF08450.12 ETS64207.1 - 0.043 13.4 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Atg14 PF10186.9 ETS64207.1 - 4.3 6.3 10.1 1.3 8.1 7.1 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3147 PF11345.8 ETS64210.1 - 0.039 14.3 0.9 0.069 13.5 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3147) RNB PF00773.19 ETS64211.1 - 6.2e-95 318.3 0.0 8.8e-95 317.8 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 ETS64211.1 - 1.8e-22 79.1 0.2 3.5e-22 78.2 0.2 1.5 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 ETS64211.1 - 6.8e-20 71.3 0.0 1.8e-19 69.9 0.0 1.8 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 ETS64211.1 - 1.7e-17 63.2 0.0 3.8e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 ETS64211.1 - 1.2e-09 38.6 0.5 4.5e-09 36.7 0.5 2.1 1 1 0 1 1 1 1 PIN domain CSD2 PF17876.1 ETS64211.1 - 3.1e-07 30.5 0.0 0.00019 21.5 0.0 3.2 3 0 0 3 3 3 1 Cold shock domain OB_RNB PF08206.11 ETS64211.1 - 0.016 14.9 0.0 0.068 12.9 0.1 2.1 2 0 0 2 2 2 0 Ribonuclease B OB domain DSPc PF00782.20 ETS64212.1 - 7.4e-19 67.9 0.4 8.8e-16 57.9 0.6 2.7 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETS64212.1 - 0.0038 16.8 0.0 0.0063 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase AA_permease PF00324.21 ETS64213.1 - 6.6e-116 387.7 35.4 8.2e-116 387.4 35.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS64213.1 - 9.5e-34 116.9 38.1 1.4e-33 116.4 37.9 1.3 1 1 0 1 1 1 1 Amino acid permease DFP PF04127.15 ETS64214.1 - 4e-18 65.9 0.0 5.2e-10 39.5 0.0 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein zf-H2C2_2 PF13465.6 ETS64215.1 - 1.8e-08 34.4 0.6 1.8e-08 34.4 0.6 3.3 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 ETS64215.1 - 1.3e-07 31.6 11.1 1.9e-06 28.0 0.6 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 ETS64215.1 - 3.4e-05 24.4 17.9 0.0024 18.4 1.6 4.5 2 2 3 5 5 5 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ETS64215.1 - 0.00013 22.5 10.9 0.0056 17.4 0.5 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETS64215.1 - 0.0038 17.2 4.2 0.11 12.5 0.0 3.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-met PF12874.7 ETS64215.1 - 0.0095 16.3 1.4 5.2 7.6 0.0 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf_ZIC PF18366.1 ETS64215.1 - 0.12 12.5 8.1 2.9 8.1 1.9 3.7 3 1 0 3 3 3 0 Zic proteins zinc finger domain Whi5 PF08528.11 ETS64216.1 - 0.039 13.6 0.2 0.065 12.9 0.2 1.4 1 0 0 1 1 1 0 Whi5 like PINIT PF14324.6 ETS64217.1 - 2.5e-29 102.5 0.1 3.8e-29 101.9 0.1 1.3 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 ETS64217.1 - 9.8e-22 76.4 7.5 1.7e-21 75.7 7.5 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 ETS64217.1 - 8.3e-06 25.5 1.5 1.7e-05 24.5 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Mitofilin PF09731.9 ETS64217.1 - 0.22 10.3 1.3 0.33 9.8 1.3 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Prok-RING_4 PF14447.6 ETS64217.1 - 0.44 10.5 4.8 0.99 9.3 4.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 RNase_T PF00929.24 ETS64218.1 - 2.2e-07 31.6 0.0 4.4e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 Exonuclease CHORD PF04968.12 ETS64218.1 - 0.054 14.2 1.1 0.17 12.6 1.1 1.8 1 0 0 1 1 1 0 CHORD DUF2180 PF09947.9 ETS64218.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) Peroxidase_2 PF01328.17 ETS64219.1 - 6.1e-42 144.3 0.0 1.2e-41 143.3 0.0 1.5 1 0 0 1 1 1 1 Peroxidase, family 2 DUF543 PF04418.12 ETS64219.1 - 2.8e-25 88.1 1.0 6.8e-25 86.9 1.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF543) DUF4536 PF15055.6 ETS64219.1 - 0.00039 20.6 0.7 0.0012 19.1 0.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4536) DUF883 PF05957.13 ETS64219.1 - 0.023 15.3 5.2 0.36 11.4 3.2 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) ATP-synt_B PF00430.18 ETS64219.1 - 5.3 7.1 9.5 8.9 6.4 9.5 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) MT0933_antitox PF14013.6 ETS64219.1 - 5.3 7.4 16.9 10 6.5 16.9 1.4 1 0 0 1 1 1 0 MT0933-like antitoxin protein AA_permease PF00324.21 ETS64220.1 - 1e-117 393.7 45.0 1.3e-117 393.4 45.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS64220.1 - 5.8e-35 120.9 47.5 7.1e-35 120.7 47.5 1.0 1 0 0 1 1 1 1 Amino acid permease DUF4231 PF14015.6 ETS64220.1 - 0.5 10.9 5.0 5.4 7.5 0.3 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) Ctr PF04145.15 ETS64221.1 - 4.2e-39 134.5 1.8 6.8e-39 133.8 1.8 1.3 1 0 0 1 1 1 1 Ctr copper transporter family Sensor PF13796.6 ETS64221.1 - 0.013 15.6 2.5 0.023 14.8 2.5 1.4 1 0 0 1 1 1 0 Putative sensor Ferric_reduct PF01794.19 ETS64222.1 - 1.7e-24 86.3 10.0 1.7e-24 86.3 10.0 2.7 3 0 0 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ETS64222.1 - 1.7e-13 51.0 0.0 2.5e-13 50.4 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ETS64222.1 - 1.1e-12 48.0 0.0 2.2e-12 47.0 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 ETS64222.1 - 7.3e-08 33.0 0.0 2.6e-06 28.0 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FixQ PF05545.11 ETS64222.1 - 0.82 9.7 5.1 6.6 6.8 0.2 3.1 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Xan_ur_permease PF00860.20 ETS64223.1 - 6.3e-60 202.9 37.3 6.3e-60 202.9 37.3 1.5 1 1 0 1 1 1 1 Permease family ATP1G1_PLM_MAT8 PF02038.16 ETS64223.1 - 0.084 12.3 0.3 0.7 9.4 0.3 2.6 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family dCMP_cyt_deam_1 PF00383.23 ETS64225.1 - 7.4e-13 48.3 0.7 9.6e-13 47.9 0.1 1.5 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETS64225.1 - 2.9e-08 33.5 0.1 8.3e-08 32.1 0.1 1.7 1 1 0 1 1 1 1 MafB19-like deaminase DIOX_N PF14226.6 ETS64226.1 - 3.7e-20 72.8 0.0 5.9e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETS64226.1 - 1.8e-16 60.5 0.0 3.1e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily UQ_con PF00179.26 ETS64227.1 - 5.5e-47 158.9 0.0 6.1e-47 158.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETS64227.1 - 0.0027 17.4 0.0 0.0034 17.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ETS64227.1 - 0.0097 15.8 0.0 0.018 14.9 0.0 1.5 1 1 0 1 1 1 1 UEV domain RWD PF05773.22 ETS64227.1 - 0.16 12.3 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 RWD domain Ion_trans PF00520.31 ETS64228.1 - 0.00095 18.5 21.8 0.0031 16.8 21.8 1.8 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETS64228.1 - 0.031 13.0 10.5 0.16 10.6 10.5 2.1 1 1 0 1 1 1 0 Polycystin cation channel GSK-3_bind PF05350.12 ETS64228.1 - 0.084 12.2 0.3 0.14 11.5 0.3 1.2 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding Phage_Gp19 PF09355.10 ETS64228.1 - 0.099 13.1 0.0 1.2 9.5 0.0 2.5 2 1 1 3 3 3 0 Phage protein Gp19/Gp15/Gp42 Nucleoporin_FG2 PF15967.5 ETS64228.1 - 0.38 9.3 1.5 0.53 8.8 1.5 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region zf-CCHC_3 PF13917.6 ETS64230.1 - 0.64 10.0 7.6 0.59 10.1 4.7 2.1 1 1 1 2 2 2 0 Zinc knuckle CEBP_ZZ PF16366.5 ETS64230.1 - 5.6 7.3 14.1 0.65 10.3 2.7 2.2 1 1 1 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Zn_clus PF00172.18 ETS64231.1 - 1.2e-06 28.5 10.7 1.2e-06 28.5 10.7 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GAS PF13851.6 ETS64231.1 - 0.15 11.4 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TFIIE_alpha PF02002.17 ETS64232.1 - 2.4e-11 43.4 1.4 6.4e-11 42.0 1.1 1.8 2 0 0 2 2 2 1 TFIIE alpha subunit DASH_Dam1 PF08653.10 ETS64232.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Dam1 Glycos_transf_4 PF00953.21 ETS64233.1 - 7.9e-35 120.2 3.7 7.9e-35 120.2 3.7 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 4 SKG6 PF08693.10 ETS64233.1 - 0.025 14.0 1.6 0.025 14.0 1.6 2.1 2 0 0 2 2 2 0 Transmembrane alpha-helix domain PH PF00169.29 ETS64234.1 - 1.1e-06 29.1 0.0 2.7e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 PH domain CSRNP_N PF16019.5 ETS64234.1 - 0.0054 16.7 0.2 0.0054 16.7 0.2 2.0 2 0 0 2 2 2 1 Cysteine/serine-rich nuclear protein N-terminus AIP3 PF03915.13 ETS64234.1 - 0.046 12.8 3.9 0.082 12.0 3.9 1.3 1 0 0 1 1 1 0 Actin interacting protein 3 adh_short_C2 PF13561.6 ETS64235.1 - 3.5e-40 138.0 1.1 4.1e-40 137.8 1.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS64235.1 - 5e-30 104.4 0.3 6.2e-30 104.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS64235.1 - 2.2e-07 31.0 3.1 1.6e-06 28.1 3.1 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS64235.1 - 0.0029 17.1 0.4 0.01 15.3 0.4 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ETS64235.1 - 0.005 16.7 3.8 0.0079 16.1 2.7 1.8 2 0 0 2 2 2 1 NAD(P)H-binding CRAL_TRIO PF00650.20 ETS64236.1 - 6.7e-19 68.2 0.0 1e-18 67.5 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DUF2841 PF11001.8 ETS64237.1 - 1.3e-38 131.8 0.8 1.9e-38 131.3 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2841) TFIIA_gamma_C PF02751.14 ETS64238.1 - 2.4e-19 69.2 0.4 3.6e-19 68.6 0.4 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 ETS64238.1 - 1.5e-14 53.7 0.1 2.1e-14 53.2 0.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain DJ-1_PfpI PF01965.24 ETS64239.1 - 1.1e-41 142.4 0.0 1.4e-41 142.1 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ETS64239.1 - 8.5e-05 22.3 0.0 0.00016 21.4 0.0 1.7 1 1 0 1 1 1 1 ThiJ/PfpI family-like GATase_3 PF07685.14 ETS64239.1 - 0.0013 18.4 0.0 0.0019 17.8 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 ETS64239.1 - 0.0074 16.2 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 SNO glutamine amidotransferase family Catalase_C PF18011.1 ETS64239.1 - 0.03 14.0 1.0 0.043 13.4 0.1 1.7 2 0 0 2 2 2 0 C-terminal domain found in long catalases DUF1729 PF08354.10 ETS64239.1 - 0.21 10.5 0.1 0.3 9.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1729) Yae1_N PF09811.9 ETS64240.1 - 7.9e-11 41.5 0.8 1.8e-10 40.3 0.8 1.7 1 0 0 1 1 1 1 Essential protein Yae1, N terminal SAM_Exu PF18609.1 ETS64240.1 - 0.38 10.9 1.2 0.86 9.7 1.2 1.5 1 0 0 1 1 1 0 Exuperantia SAM-like domain ATP19 PF11022.8 ETS64241.1 - 2.1e-25 88.8 0.2 3e-25 88.4 0.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit K Pyr_redox_2 PF07992.14 ETS64242.1 - 3.4e-39 134.8 0.0 5.2e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS64242.1 - 6.4e-13 49.1 0.4 2.5e-07 31.1 0.1 3.8 3 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 ETS64242.1 - 4.3e-12 44.7 3.2 1.1e-05 24.6 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETS64242.1 - 3.7e-10 38.9 3.0 0.00014 21.5 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETS64242.1 - 4.4e-10 39.9 0.1 0.00034 21.0 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETS64242.1 - 5e-08 32.1 2.3 0.0015 18.0 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETS64242.1 - 2.8e-05 23.9 2.4 0.018 14.9 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair Pyr_redox_3 PF13738.6 ETS64242.1 - 0.015 14.5 2.6 2 7.6 3.2 3.1 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ETS64242.1 - 0.023 15.1 0.7 1.1 9.8 0.0 2.7 3 0 0 3 3 3 0 Putative NAD(P)-binding Rer1 PF03248.13 ETS64243.1 - 1.5e-77 259.1 0.0 1.8e-77 258.9 0.0 1.1 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 ETS64243.1 - 0.21 11.2 3.8 0.091 12.4 0.5 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) MgsA_C PF12002.8 ETS64244.1 - 4.7e-49 166.5 0.0 8.8e-49 165.7 0.0 1.4 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 ETS64244.1 - 3.8e-25 88.0 0.5 1.1e-24 86.5 0.5 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 ETS64244.1 - 3e-14 53.6 0.0 1.1e-13 51.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETS64244.1 - 6.3e-14 52.0 0.0 4e-12 46.1 0.0 2.3 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETS64244.1 - 6.3e-08 33.2 4.1 0.0001 22.8 0.0 3.1 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 ETS64244.1 - 5.7e-07 29.9 0.1 6.3e-06 26.5 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ETS64244.1 - 2.3e-06 27.7 0.0 4.3e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETS64244.1 - 4.8e-06 26.6 0.2 2.4e-05 24.4 0.2 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETS64244.1 - 4.1e-05 23.1 0.2 0.076 12.4 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 ETS64244.1 - 0.00014 21.6 0.0 0.00038 20.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 ETS64244.1 - 0.00031 20.9 0.0 0.00089 19.4 0.0 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 ETS64244.1 - 0.00076 20.0 0.0 0.0016 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 ETS64244.1 - 0.0015 18.2 0.1 1.1 8.9 0.1 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain TniB PF05621.11 ETS64244.1 - 0.0021 17.5 0.0 0.024 14.0 0.0 2.2 1 1 2 3 3 3 1 Bacterial TniB protein AAA_24 PF13479.6 ETS64244.1 - 0.0046 16.7 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETS64244.1 - 0.0049 17.1 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sgf11 PF08209.11 ETS64244.1 - 0.0057 16.2 0.0 0.012 15.1 0.0 1.6 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) NB-ARC PF00931.22 ETS64244.1 - 0.0062 15.8 0.1 0.74 9.0 0.0 2.2 1 1 0 2 2 2 1 NB-ARC domain AAA_19 PF13245.6 ETS64244.1 - 0.012 16.0 1.1 1.1 9.6 1.1 2.5 1 1 0 1 1 1 0 AAA domain XAF1_C PF18608.1 ETS64244.1 - 0.013 15.1 2.5 0.03 13.9 2.5 1.5 1 0 0 1 1 1 0 XIAP-associated factor 1 C-terminal domain Viral_helicase1 PF01443.18 ETS64244.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 ETS64244.1 - 0.013 14.6 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 ETS64244.1 - 0.015 15.5 0.0 0.035 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETS64244.1 - 0.018 15.5 0.0 0.044 14.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_2 PF07724.14 ETS64244.1 - 0.018 15.1 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_25 PF13481.6 ETS64244.1 - 0.019 14.6 1.9 0.035 13.7 0.2 2.2 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ETS64244.1 - 0.021 14.8 0.1 3.6 7.4 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ETS64244.1 - 0.032 13.9 0.0 0.079 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 ETS64244.1 - 0.037 13.8 0.1 0.088 12.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETS64244.1 - 0.043 14.2 0.0 0.091 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 ETS64244.1 - 0.1 12.4 0.1 0.76 9.6 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETS64244.1 - 0.26 11.2 2.4 0.65 9.9 0.7 2.5 2 1 0 2 2 1 0 NACHT domain RRM_1 PF00076.22 ETS64245.1 - 7.4e-08 32.1 0.0 1.4e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 ETS64245.1 - 0.063 14.1 0.0 0.14 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase II-binding domain. Aldedh PF00171.22 ETS64246.1 - 2.6e-120 402.0 0.1 3.1e-120 401.8 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETS64246.1 - 0.11 11.5 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) DUF1338 PF07063.13 ETS64247.1 - 1.6e-110 369.4 0.0 2e-110 369.0 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) Transp_cyt_pur PF02133.15 ETS64248.1 - 8.1e-131 436.8 38.1 9.4e-131 436.6 38.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin p450 PF00067.22 ETS64249.1 - 3.6e-74 250.2 0.0 5.2e-74 249.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 BPL_LplA_LipB PF03099.19 ETS64250.1 - 1.6e-05 24.9 0.0 2.5e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family FAR1 PF03101.15 ETS64252.1 - 2.1e-05 25.1 0.1 4.5e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 FAR1 DNA-binding domain AFT PF08731.11 ETS64252.1 - 0.0088 16.4 0.0 0.03 14.7 0.0 2.0 1 0 0 1 1 1 1 Transcription factor AFT zf-C2H2_10 PF16588.5 ETS64252.1 - 0.042 13.6 3.9 0.076 12.7 3.9 1.4 1 0 0 1 1 1 0 C2H2 zinc-finger DDE_Tnp_1_6 PF13751.6 ETS64252.1 - 0.057 13.6 0.4 0.15 12.3 0.4 1.7 1 0 0 1 1 1 0 Transposase DDE domain zf-CCHC PF00098.23 ETS64252.1 - 0.16 12.1 3.2 0.49 10.6 3.2 1.8 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_6 PF15288.6 ETS64252.1 - 3.4 7.6 7.4 0.43 10.5 1.7 2.6 2 0 0 2 2 2 0 Zinc knuckle DUF4551 PF15087.6 ETS64252.1 - 3.5 6.3 11.1 0.73 8.6 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4551) Acyltransferase PF01553.21 ETS64253.1 - 0.005 16.4 0.0 0.087 12.4 0.0 2.2 2 0 0 2 2 2 1 Acyltransferase PAN_4 PF14295.6 ETS64254.1 - 8.8e-05 22.3 1.9 0.00017 21.4 1.9 1.4 1 0 0 1 1 1 1 PAN domain Fringe PF02434.16 ETS64254.1 - 0.00092 18.7 0.3 0.0028 17.2 0.3 1.7 1 1 0 1 1 1 1 Fringe-like DnaJ PF00226.31 ETS64255.1 - 2.2e-18 66.1 1.8 4.6e-18 65.1 1.8 1.6 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 ETS64255.1 - 0.16 12.2 1.8 0.27 11.5 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Bacteriocin_IIc PF10439.9 ETS64255.1 - 0.66 10.1 6.0 1.2 9.3 6.0 1.4 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide DUF202 PF02656.15 ETS64256.1 - 3.9e-20 72.1 0.5 1.5e-19 70.2 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) RCC1 PF00415.18 ETS64257.1 - 1.4e-23 83.2 2.2 5.8e-05 23.6 0.0 6.4 5 2 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETS64257.1 - 2e-16 59.3 17.7 0.00029 20.5 0.3 6.3 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat Lactamase_B_4 PF13691.6 ETS64260.1 - 1.6e-13 50.1 0.0 4.3e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 ETS64260.1 - 9.7e-12 44.8 6.4 1e-10 41.5 5.5 2.8 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ETS64260.1 - 9e-05 22.6 2.0 0.00033 20.7 2.2 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Cyt-b5 PF00173.28 ETS64261.1 - 9.1e-22 77.0 1.6 1.5e-21 76.3 0.2 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 ETS64261.1 - 5.7e-15 55.8 15.2 5.7e-15 55.8 15.2 2.2 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily PBS_linker_poly PF00427.21 ETS64261.1 - 0.044 13.8 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide MMM1 PF10296.9 ETS64262.1 - 4e-80 269.4 0.0 3.5e-79 266.2 0.0 1.9 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 HemY_N PF07219.13 ETS64262.1 - 1 9.6 3.9 0.64 10.2 1.1 2.0 2 0 0 2 2 2 0 HemY protein N-terminus Glyco_hydro_16 PF00722.21 ETS64263.1 - 1.4e-14 54.0 0.4 2.8e-14 53.0 0.3 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Glyco_trans_2_3 PF13632.6 ETS64265.1 - 5.3e-51 173.3 4.2 5.3e-51 173.3 4.2 2.5 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ETS64265.1 - 0.0003 20.6 0.0 0.0066 16.3 0.0 2.7 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ETS64265.1 - 0.013 15.0 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 Atx10homo_assoc PF09759.9 ETS64266.1 - 1.8e-21 76.0 0.1 1.9e-18 66.3 0.0 4.0 3 1 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain DUF2012 PF09430.10 ETS64267.1 - 1.1e-37 128.9 0.0 1.5e-37 128.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) CarboxypepD_reg PF13620.6 ETS64267.1 - 0.13 12.5 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain ERG4_ERG24 PF01222.17 ETS64268.1 - 5.6e-145 483.4 6.9 6.8e-145 483.1 6.9 1.1 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ETS64268.1 - 1.9e-06 27.5 0.4 5.3e-06 26.1 0.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ETS64268.1 - 0.00061 20.2 0.3 0.0026 18.1 0.0 2.3 2 0 0 2 2 2 1 Phospholipid methyltransferase ICMT PF04140.14 ETS64268.1 - 0.026 14.9 0.0 0.098 13.1 0.0 1.9 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ORC6 PF05460.13 ETS64268.1 - 9.3 5.4 10.2 12 5.0 10.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Zip PF02535.22 ETS64270.1 - 2.1e-50 171.8 0.8 3.4e-50 171.1 0.8 1.3 1 1 0 1 1 1 1 ZIP Zinc transporter MIG-14_Wnt-bd PF06664.12 ETS64270.1 - 0.071 12.3 0.1 0.16 11.2 0.1 1.5 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Cation_ATPase_C PF00689.21 ETS64270.1 - 0.11 12.2 1.9 0.2 11.4 0.0 2.2 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus DUF1772 PF08592.11 ETS64270.1 - 0.34 11.2 0.1 0.34 11.2 0.1 3.5 2 2 1 3 3 3 0 Domain of unknown function (DUF1772) DLH PF01738.18 ETS64271.1 - 3.3e-20 72.6 0.0 3.8e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 ETS64271.1 - 0.055 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold adh_short PF00106.25 ETS64272.1 - 3.2e-35 121.4 0.0 3.9e-35 121.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS64272.1 - 1.1e-31 110.2 0.1 1.5e-31 109.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS64272.1 - 1.2e-05 25.3 0.2 1.9e-05 24.7 0.2 1.3 1 0 0 1 1 1 1 KR domain ThiF PF00899.21 ETS64272.1 - 0.07 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 ThiF family 3HCDH_N PF02737.18 ETS64273.1 - 2.7e-31 108.8 0.0 4.6e-31 108.1 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ETS64273.1 - 1.3e-17 64.2 0.0 2.4e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain SGL PF08450.12 ETS64273.1 - 1.7e-05 24.5 0.1 0.00012 21.7 0.1 2.3 2 1 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Ldl_recept_b PF00058.17 ETS64273.1 - 0.0069 16.8 0.9 1.1 9.8 0.0 4.0 5 0 0 5 5 5 1 Low-density lipoprotein receptor repeat class B NAD_Gly3P_dh_N PF01210.23 ETS64273.1 - 0.045 13.7 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Arylesterase PF01731.20 ETS64273.1 - 0.088 13.0 0.0 1.8 8.8 0.0 2.9 4 0 0 4 4 4 0 Arylesterase NAD_binding_1 PF00175.21 ETS64274.1 - 2.2e-29 102.3 0.0 5.3e-29 101.1 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ETS64274.1 - 3.4e-27 94.7 0.0 5.9e-27 93.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 ETS64274.1 - 3.6e-20 71.9 0.1 1.1e-19 70.3 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain NAD_binding_6 PF08030.12 ETS64274.1 - 9.5e-08 32.3 0.0 2.4e-05 24.5 0.0 2.6 2 0 0 2 2 2 2 Ferric reductase NAD binding domain p450 PF00067.22 ETS64275.1 - 2.1e-70 237.7 0.0 2.6e-70 237.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 FA_hydroxylase PF04116.13 ETS64277.1 - 7.4e-24 84.6 11.8 7.4e-24 84.6 11.8 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily VRP3 PF03536.15 ETS64278.1 - 0.12 11.9 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Salmonella virulence-associated 28kDa protein Abhydrolase_1 PF00561.20 ETS64279.1 - 6.9e-18 65.2 0.0 1.9e-15 57.2 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ETS64279.1 - 1.2e-15 57.5 0.0 2.5e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Hep_59 PF07052.11 ETS64280.1 - 5.5e-27 94.6 0.5 5.5e-27 94.6 0.5 2.5 3 0 0 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 Glutaredoxin PF00462.24 ETS64281.1 - 1.4e-11 44.4 0.0 2.6e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 ETS64281.1 - 0.085 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GvpG PF05120.12 ETS64281.1 - 0.11 12.6 0.7 0.53 10.3 0.7 2.1 1 1 1 2 2 2 0 Gas vesicle protein G TraF PF13728.6 ETS64281.1 - 0.15 11.8 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein GST_N_2 PF13409.6 ETS64281.1 - 0.15 12.3 0.1 0.4 11.0 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain SBDS_C PF09377.10 ETS64282.1 - 9.5e-38 128.8 0.0 1.6e-37 128.1 0.0 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 ETS64282.1 - 1.6e-35 121.0 0.5 4.5e-35 119.6 0.3 1.8 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Capsid_N PF16903.5 ETS64282.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Major capsid protein N-terminus PMT PF02366.18 ETS64283.1 - 3.7e-77 259.2 15.7 3.7e-77 259.2 15.7 1.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ETS64283.1 - 5.2e-65 218.8 6.2 5.2e-65 218.8 6.2 2.7 2 1 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ETS64283.1 - 5.3e-21 75.3 0.5 8.6e-21 74.6 0.5 1.3 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ETS64283.1 - 0.00026 21.2 11.8 0.00026 21.2 11.8 3.2 4 1 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase WD40 PF00400.32 ETS64284.1 - 5.8e-42 140.9 11.6 1.2e-06 29.1 0.0 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64284.1 - 8.8e-15 54.8 0.0 0.0011 19.2 0.0 5.7 5 1 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 ETS64284.1 - 4.2e-13 48.6 6.7 7.5e-13 47.8 6.7 1.4 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Ge1_WD40 PF16529.5 ETS64284.1 - 3.4e-06 26.3 0.0 0.059 12.3 0.0 3.5 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETS64284.1 - 0.0015 17.9 0.0 1.8 7.8 0.0 2.6 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETS64284.1 - 0.0035 16.1 3.4 1.6 7.2 0.0 4.1 2 1 2 5 5 5 2 Nucleoporin Nup120/160 SCHIP-1 PF10148.9 ETS64284.1 - 0.0055 16.4 0.6 0.0083 15.8 0.6 1.2 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 Nbas_N PF15492.6 ETS64284.1 - 0.015 14.7 0.2 0.77 9.0 0.0 3.2 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal EBP50_C PF09007.11 ETS64284.1 - 0.035 15.1 1.1 0.063 14.3 1.1 1.4 1 0 0 1 1 1 0 EBP50, C-terminal DUF1525 PF07511.11 ETS64284.1 - 0.071 13.3 0.6 0.15 12.2 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Bestrophin PF01062.21 ETS64285.1 - 1.2e-37 129.9 0.1 1.8e-37 129.3 0.1 1.1 1 0 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel SLATT_3 PF18184.1 ETS64285.1 - 2.5 8.2 6.9 1.6 8.8 4.0 2.0 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 3 Zn_clus PF00172.18 ETS64286.1 - 0.00063 19.8 6.6 0.0012 19.0 6.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-CCCH PF00642.24 ETS64287.1 - 8.5e-18 63.8 33.1 0.00013 21.7 0.7 5.4 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS64287.1 - 1.7e-14 53.3 32.5 6.4e-06 26.0 2.7 5.6 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 ETS64287.1 - 9e-09 36.0 21.7 0.00012 22.7 0.4 5.1 1 1 4 5 5 5 4 Torus domain zf-CCHC PF00098.23 ETS64287.1 - 5.3e-06 26.3 1.0 5.3e-06 26.3 1.0 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCCH_4 PF18044.1 ETS64287.1 - 6.8e-05 22.6 0.5 6.8e-05 22.6 0.5 4.7 4 0 0 4 4 4 1 CCCH-type zinc finger zf-CCCH_3 PF15663.5 ETS64287.1 - 0.082 13.1 16.3 0.81 9.9 3.4 3.9 1 1 2 3 3 3 0 Zinc-finger containing family Ribosomal_L24e PF01246.20 ETS64288.1 - 9.6e-31 105.8 6.4 1.9e-30 104.9 6.4 1.5 1 0 0 1 1 1 1 Ribosomal protein L24e HAGH_C PF16123.5 ETS64288.1 - 0.077 13.5 1.8 0.12 12.9 1.4 1.7 1 1 0 1 1 1 0 Hydroxyacylglutathione hydrolase C-terminus Amino_oxidase PF01593.24 ETS64290.1 - 5.4e-62 210.5 0.0 7.7e-62 210.0 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS64290.1 - 1.6e-14 53.9 0.2 5.6e-14 52.1 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETS64290.1 - 1.6e-06 27.6 0.1 6.9e-06 25.5 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS64290.1 - 6.7e-06 26.6 0.5 3.5e-05 24.3 0.3 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS64290.1 - 7e-06 25.4 0.7 1.5e-05 24.3 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETS64290.1 - 2.1e-05 23.9 0.3 4.3e-05 22.9 0.3 1.5 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ETS64290.1 - 2.3e-05 23.3 0.7 0.00029 19.7 0.4 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 ETS64290.1 - 8.6e-05 22.1 0.1 0.00013 21.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ETS64290.1 - 0.00013 21.4 0.8 0.00023 20.5 0.8 1.4 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETS64290.1 - 0.00016 21.4 1.1 0.00025 20.8 0.3 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ETS64290.1 - 0.00041 19.5 0.5 0.028 13.5 0.1 2.9 3 0 0 3 3 3 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ETS64290.1 - 0.00065 19.7 0.1 0.37 10.8 0.1 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 ETS64290.1 - 0.00077 18.8 0.2 0.32 10.2 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS64290.1 - 0.0073 15.4 0.5 0.014 14.5 0.5 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein MFS_1 PF07690.16 ETS64292.1 - 5.8e-35 120.8 44.4 2.3e-34 118.9 44.4 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64292.1 - 7.6e-13 48.1 9.7 7.6e-13 48.1 9.7 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ETS64292.1 - 4.2e-08 32.1 18.2 7.7e-08 31.2 18.2 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Nramp PF01566.18 ETS64293.1 - 5.3e-91 305.3 15.4 7.1e-51 173.3 2.2 2.1 2 0 0 2 2 2 2 Natural resistance-associated macrophage protein Wzy_C PF04932.15 ETS64293.1 - 8.2 6.0 10.4 26 4.4 5.1 3.3 3 1 0 3 3 3 0 O-Antigen ligase DUF1996 PF09362.10 ETS64294.1 - 1.6e-66 224.6 0.0 2.3e-66 224.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) Zn_clus PF00172.18 ETS64295.1 - 0.0052 16.9 6.5 0.0093 16.1 6.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Parvo_coat_N PF08398.10 ETS64295.1 - 0.027 14.6 0.2 0.067 13.4 0.2 1.6 1 0 0 1 1 1 0 Parvovirus coat protein VP1 PseudoU_synth_1 PF01416.20 ETS64296.1 - 2e-10 41.1 0.0 1.2e-08 35.4 0.0 2.5 2 0 0 2 2 2 1 tRNA pseudouridine synthase EF-1_beta_acid PF10587.9 ETS64296.1 - 2.2 8.8 9.0 0.94 10.0 3.0 3.0 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region TPR_1 PF00515.28 ETS64297.1 - 2e-30 103.3 10.8 2.5e-05 23.9 0.0 7.7 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETS64297.1 - 2.5e-28 95.9 18.2 2.1e-05 24.3 0.0 8.5 9 0 0 9 9 8 6 Tetratricopeptide repeat DnaJ PF00226.31 ETS64297.1 - 4.4e-22 78.0 3.3 9.1e-22 77.0 3.3 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_8 PF13181.6 ETS64297.1 - 1.3e-16 59.3 8.9 0.043 14.0 0.0 8.2 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 ETS64297.1 - 1.2e-15 57.5 20.3 6.7e-05 23.1 3.5 6.0 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 ETS64297.1 - 5.4e-15 55.7 34.5 5.1e-06 26.9 2.4 6.3 4 1 2 7 7 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETS64297.1 - 1.5e-14 53.5 22.8 0.0002 21.9 0.6 8.0 5 3 2 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETS64297.1 - 2.8e-14 53.5 28.4 2e-07 31.5 0.4 5.6 5 1 0 6 6 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETS64297.1 - 7.9e-12 44.7 9.4 0.00093 18.8 0.0 6.0 5 1 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 ETS64297.1 - 6.1e-10 38.4 9.4 0.084 12.9 0.1 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS64297.1 - 7.5e-10 38.5 6.6 0.15 12.5 0.0 6.1 7 0 0 7 7 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETS64297.1 - 1.6e-08 34.6 21.7 0.00019 21.5 2.3 5.3 5 1 1 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS64297.1 - 2.3e-07 30.9 13.1 0.11 12.8 0.2 4.7 3 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ETS64297.1 - 3.8e-05 24.0 9.6 3.1 8.6 0.1 6.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 ETS64297.1 - 0.0045 17.5 11.5 0.25 12.1 0.4 6.1 6 0 0 6 6 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETS64297.1 - 0.033 13.6 3.3 0.054 13.0 0.1 2.7 2 0 0 2 2 2 0 SHNi-TPR TPR_10 PF13374.6 ETS64297.1 - 0.037 13.9 16.5 1.2 9.1 0.2 5.7 4 1 1 5 5 5 0 Tetratricopeptide repeat BTAD PF03704.17 ETS64297.1 - 0.051 14.0 26.6 2.8 8.4 13.7 5.4 3 2 1 4 4 4 0 Bacterial transcriptional activator domain Coatomer_E PF04733.14 ETS64297.1 - 0.11 11.9 0.1 0.11 11.9 0.1 3.9 3 1 2 5 5 5 0 Coatomer epsilon subunit AAA_lid_7 PF17867.1 ETS64297.1 - 0.13 12.5 0.0 0.36 11.0 0.0 1.7 1 0 0 1 1 1 0 Midasin AAA lid domain DUF3856 PF12968.7 ETS64297.1 - 0.22 11.6 14.0 0.063 13.3 5.8 3.6 3 1 0 3 3 3 0 Domain of Unknown Function (DUF3856) SOG2 PF10428.9 ETS64297.1 - 0.4 9.8 7.7 0.56 9.3 7.7 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF627 PF04781.12 ETS64297.1 - 3.3 7.8 15.9 23 5.1 0.5 4.7 4 1 0 4 4 4 0 Protein of unknown function (DUF627) AP_endonuc_2 PF01261.24 ETS64298.1 - 8.2e-23 80.9 0.0 1.6e-21 76.8 0.0 2.3 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel Shikimate_dh_N PF08501.11 ETS64298.1 - 6.5e-09 35.9 0.0 1.8e-08 34.5 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.20 ETS64298.1 - 0.027 14.5 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sugar_tr PF00083.24 ETS64299.1 - 8.6e-116 387.5 21.0 1.1e-115 387.1 21.0 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS64299.1 - 1.4e-28 99.8 27.7 1.4e-28 99.8 27.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Plus-3 PF03126.18 ETS64299.1 - 2e-21 76.6 0.0 4.2e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 Plus-3 domain Beta-lactamase PF00144.24 ETS64299.1 - 0.33 10.1 3.5 0.18 11.0 0.6 1.9 2 0 0 2 2 2 0 Beta-lactamase UCH PF00443.29 ETS64301.1 - 7.7e-64 215.6 0.0 1.3e-63 214.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS64301.1 - 5.2e-16 59.1 0.0 1.5e-14 54.3 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 ETS64301.1 - 1.6e-07 31.5 0.1 6.2e-07 29.6 0.1 1.9 2 0 0 2 2 2 1 USP8 dimerisation domain zf-MIZ PF02891.20 ETS64301.1 - 0.021 14.6 0.5 0.042 13.6 0.5 1.5 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Rhodanese PF00581.20 ETS64301.1 - 0.051 14.1 0.0 0.18 12.3 0.0 2.0 1 1 0 1 1 1 0 Rhodanese-like domain DivIVA PF05103.13 ETS64301.1 - 0.086 12.9 1.8 8 6.6 0.0 2.5 2 0 0 2 2 2 0 DivIVA protein Aldedh PF00171.22 ETS64302.1 - 1.7e-159 531.3 0.0 1.9e-159 531.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETS64302.1 - 0.0052 15.9 0.0 0.0082 15.2 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) DUF1487 PF07368.11 ETS64302.1 - 0.18 11.2 0.0 0.35 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1487) PX PF00787.24 ETS64303.1 - 1.1e-12 47.9 0.0 2e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 PX domain NPV_P10 PF05531.12 ETS64303.1 - 0.62 10.6 4.0 1.7 9.2 2.6 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Actin PF00022.19 ETS64304.1 - 3.1e-111 371.9 0.0 1.4e-110 369.7 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETS64304.1 - 0.02 13.7 0.0 0.074 11.9 0.0 1.8 1 1 0 1 1 1 0 MreB/Mbl protein PCNA_N PF00705.18 ETS64306.1 - 4e-48 162.3 1.6 7.1e-48 161.5 1.2 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ETS64306.1 - 9.7e-44 148.6 0.5 1.3e-21 77.1 0.1 2.7 2 1 1 3 3 3 2 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 ETS64306.1 - 0.00015 21.3 0.1 0.0008 18.9 0.1 2.3 1 1 0 1 1 1 1 Rad9 Bac_A_amyl_C PF18612.1 ETS64306.1 - 0.086 12.6 0.0 0.26 11.1 0.0 1.8 1 0 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain WD40 PF00400.32 ETS64307.1 - 1.3e-22 79.6 21.1 1.7e-05 25.4 0.1 8.4 8 1 1 9 9 9 5 WD domain, G-beta repeat PFU PF09070.11 ETS64307.1 - 7.3e-10 39.1 0.0 1.5e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) BBS2_Mid PF14783.6 ETS64307.1 - 0.099 12.7 0.0 36 4.5 0.0 3.7 5 0 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region RCC1_2 PF13540.6 ETS64308.1 - 2.5e-13 49.4 17.1 0.00031 20.4 0.0 6.1 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETS64308.1 - 3.5e-09 37.1 8.7 0.16 12.6 0.0 7.0 6 1 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat F-box PF00646.33 ETS64308.1 - 0.015 15.1 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 F-box domain UPF0561 PF10573.9 ETS64310.1 - 0.094 12.8 0.4 0.26 11.4 0.4 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Sugar_tr PF00083.24 ETS64311.1 - 1.4e-19 70.3 21.7 5e-13 48.7 9.6 3.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETS64311.1 - 7.5e-18 64.6 30.0 8.1e-15 54.6 10.7 2.9 1 1 1 3 3 3 2 Major Facilitator Superfamily Polyketide_cyc PF03364.20 ETS64312.1 - 2.8e-26 92.3 0.1 4.6e-26 91.5 0.1 1.4 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 ETS64312.1 - 7.2e-07 29.6 0.4 1.6e-06 28.5 0.4 1.5 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Epimerase PF01370.21 ETS64312.1 - 3.1e-05 23.6 0.0 0.00012 21.6 0.0 1.9 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS64312.1 - 0.019 14.4 0.0 0.035 13.5 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 ETS64312.1 - 0.049 13.1 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase NmrA PF05368.13 ETS64312.1 - 0.4 10.2 1.5 5.3 6.5 0.2 2.7 3 0 0 3 3 3 0 NmrA-like family MFS_1 PF07690.16 ETS64313.1 - 3.7e-35 121.5 31.5 3.7e-35 121.5 31.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Pex2_Pex12 PF04757.14 ETS64313.1 - 2.8 7.5 5.4 0.54 9.8 1.2 1.8 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region GPI-anchored PF10342.9 ETS64314.1 - 0.11 13.2 0.1 0.27 12.0 0.1 1.7 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Tim17 PF02466.19 ETS64315.1 - 9.8e-08 32.4 0.2 9.8e-08 32.4 0.2 3.3 3 0 0 3 3 3 1 Tim17/Tim22/Tim23/Pmp24 family Amnionless PF14828.6 ETS64315.1 - 0.089 11.6 0.0 0.18 10.6 0.0 1.4 1 0 0 1 1 1 0 Amnionless Phage_Coat_Gp8 PF05371.12 ETS64315.1 - 0.092 12.5 0.5 0.22 11.3 0.5 1.7 1 0 0 1 1 1 0 Phage major coat protein, Gp8 SWI-SNF_Ssr4 PF08549.10 ETS64315.1 - 1.6 7.3 8.5 4 6.0 8.5 1.6 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) 5TM-5TMR_LYT PF07694.12 ETS64315.1 - 2.9 7.4 6.3 16 4.9 0.1 3.4 3 0 0 3 3 3 0 5TMR of 5TMR-LYT ASD2 PF08687.11 ETS64315.1 - 3.6 7.0 6.7 6.6 6.2 6.7 1.3 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Ribosomal_L28e PF01778.17 ETS64316.1 - 1.4e-38 132.1 1.5 1.4e-38 132.1 1.5 2.0 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 ETS64316.1 - 4.9e-27 94.5 27.3 2e-26 92.5 27.3 2.1 1 1 0 1 1 1 1 Mak16 protein C-terminal region BUD22 PF09073.10 ETS64316.1 - 0.00063 19.2 21.5 0.0008 18.9 21.5 1.1 1 0 0 1 1 1 1 BUD22 PYC_OADA PF02436.18 ETS64316.1 - 0.002 17.9 1.1 0.0029 17.4 1.1 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain G-alpha PF00503.20 ETS64318.1 - 4.3e-84 282.7 0.0 5.4e-84 282.4 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETS64318.1 - 2.6e-11 43.3 0.0 9.5e-07 28.4 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family AAA_22 PF13401.6 ETS64318.1 - 0.00063 20.0 0.0 0.0017 18.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS64318.1 - 0.00087 19.1 0.2 0.0023 17.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETS64318.1 - 0.0023 18.5 0.0 0.0049 17.4 0.0 1.7 1 1 0 1 1 1 1 ABC transporter Roc PF08477.13 ETS64318.1 - 0.0054 16.9 0.0 0.69 10.1 0.0 2.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETS64318.1 - 0.0061 16.5 0.1 0.22 11.4 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ETS64318.1 - 0.013 15.9 1.1 0.095 13.1 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 ETS64318.1 - 0.014 14.9 0.0 3.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ETS64318.1 - 0.02 14.6 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ETS64318.1 - 0.051 13.2 0.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Gtr1_RagA PF04670.12 ETS64318.1 - 0.13 11.6 0.0 9.7 5.5 0.0 2.6 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region SPT_ssu-like PF11779.8 ETS64319.1 - 0.0097 15.5 0.1 0.014 15.0 0.1 1.4 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like START PF01852.19 ETS64320.1 - 9.3e-21 74.2 0.4 7.8e-09 35.3 0.2 3.6 3 0 0 3 3 3 3 START domain Coatamer_beta_C PF07718.12 ETS64320.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 Coatomer beta C-terminal region DUF3405 PF11885.8 ETS64321.1 - 3.2e-81 273.5 6.0 2.3e-51 175.0 0.5 3.3 1 1 2 3 3 3 3 Protein of unknown function (DUF3405) Vezatin PF12632.7 ETS64322.1 - 1.3e-18 67.4 0.0 8.3e-13 48.3 0.0 3.6 3 0 0 3 3 3 3 Mysoin-binding motif of peroxisomes Ribosomal_L21p PF00829.21 ETS64323.1 - 4.6e-22 78.2 3.3 7.1e-12 45.5 1.2 2.2 2 0 0 2 2 2 2 Ribosomal prokaryotic L21 protein UvrA_inter PF17760.1 ETS64323.1 - 0.041 14.0 0.5 0.13 12.4 0.2 1.9 2 1 0 2 2 2 0 UvrA interaction domain ATP-synt_ab PF00006.25 ETS64324.1 - 3.1e-72 242.7 0.0 4.7e-72 242.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ETS64324.1 - 9.1e-39 132.7 0.0 1.5e-38 132.0 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ETS64324.1 - 9.5e-20 70.9 1.9 2.4e-19 69.6 1.9 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 ETS64324.1 - 0.064 13.4 0.4 0.16 12.1 0.4 1.7 1 1 0 1 1 1 0 HAS barrel domain Dynamin_M PF01031.20 ETS64325.1 - 9.1e-110 366.4 0.0 1.8e-109 365.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 ETS64325.1 - 1.4e-55 187.9 0.0 3.2e-55 186.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ETS64325.1 - 9e-30 102.7 1.4 1.4e-29 102.1 0.5 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ETS64325.1 - 6.5e-05 23.0 0.5 0.0018 18.3 0.1 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 ETS64325.1 - 0.051 12.9 0.1 3.8 6.8 0.0 2.5 2 0 0 2 2 2 0 AIG1 family TipAS PF07739.13 ETS64325.1 - 0.085 13.4 0.2 0.28 11.7 0.0 1.9 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain AATase PF07247.12 ETS64326.1 - 6.2e-07 28.3 0.0 0.018 13.6 0.0 2.1 2 0 0 2 2 2 2 Alcohol acetyltransferase Condensation PF00668.20 ETS64326.1 - 0.051 12.3 0.0 2.1 6.9 0.0 2.7 3 0 0 3 3 3 0 Condensation domain DUF1752 PF08550.10 ETS64329.1 - 1e-12 47.6 3.2 2.8e-12 46.2 3.2 1.8 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TrbM PF07424.11 ETS64329.1 - 0.024 14.6 0.1 0.046 13.7 0.1 1.4 1 0 0 1 1 1 0 TrbM Tri3 PF07428.11 ETS64330.1 - 0.066 12.1 0.0 0.54 9.1 0.0 2.1 2 0 0 2 2 2 0 15-O-acetyltransferase Tri3 Cellulase PF00150.18 ETS64331.1 - 9.6e-08 31.8 0.0 1.6e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) TPPK_C PF12555.8 ETS64331.1 - 0.083 12.9 5.9 0.03 14.3 2.1 2.1 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Zw10 PF06248.13 ETS64332.1 - 8e-09 34.6 0.0 2.3e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 ETS64332.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 C terminal Dor1 PF04124.12 ETS64332.1 - 0.034 12.8 0.5 0.068 11.9 0.5 1.4 1 0 0 1 1 1 0 Dor1-like family Pns11_12 PF17464.2 ETS64334.1 - 0.029 14.1 0.3 0.06 13.0 0.3 1.5 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Ctr PF04145.15 ETS64335.1 - 8.2e-36 123.8 0.8 8.2e-36 123.8 0.8 3.4 5 0 0 5 5 5 1 Ctr copper transporter family VPS9 PF02204.18 ETS64335.1 - 2.1e-30 105.0 0.2 3.8e-30 104.2 0.2 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.16 ETS64335.1 - 5.9e-12 45.1 0.3 1.3e-11 44.0 0.3 1.6 1 0 0 1 1 1 1 CUE domain DUF5601 PF18151.1 ETS64335.1 - 7e-11 42.3 0.0 2.7e-10 40.4 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) DMA PF03474.14 ETS64335.1 - 0.0039 16.8 0.0 0.0075 15.9 0.0 1.5 1 0 0 1 1 1 1 DMRTA motif LisH PF08513.11 ETS64337.1 - 0.012 15.6 0.1 0.022 14.7 0.1 1.4 1 0 0 1 1 1 0 LisH Cutinase PF01083.22 ETS64337.1 - 0.045 13.7 1.4 0.08 12.9 1.4 1.3 1 0 0 1 1 1 0 Cutinase WD40 PF00400.32 ETS64339.1 - 4.6e-12 46.2 1.4 0.31 12.0 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat FF PF01846.19 ETS64340.1 - 2e-28 98.3 11.4 3.4e-10 40.0 0.0 5.9 6 0 0 6 6 6 4 FF domain WW PF00397.26 ETS64340.1 - 3e-12 46.4 13.0 2e-06 27.8 2.8 2.6 2 0 0 2 2 2 2 WW domain RhoGAP-FF1 PF16512.5 ETS64340.1 - 0.00028 21.5 0.9 0.006 17.2 0.1 3.4 2 1 2 4 4 4 1 p190-A and -B Rho GAPs FF domain Creatininase PF02633.14 ETS64340.1 - 0.014 14.9 2.1 0.031 13.7 1.7 1.7 1 1 0 1 1 1 0 Creatinine amidohydrolase LysR_substrate PF03466.20 ETS64340.1 - 0.039 13.3 0.0 0.09 12.1 0.0 1.6 1 0 0 1 1 1 0 LysR substrate binding domain Pex19 PF04614.12 ETS64340.1 - 8.9 6.0 16.2 0.64 9.8 2.6 3.3 2 1 1 3 3 3 0 Pex19 protein family DUF2203 PF09969.9 ETS64340.1 - 9 7.0 11.3 63 4.3 1.4 3.7 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) RRM_1 PF00076.22 ETS64341.1 - 1.9e-30 104.5 0.1 1.9e-15 56.4 0.0 5.2 4 1 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETS64341.1 - 0.0013 18.9 0.0 0.0096 16.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif RRM_9 PF18444.1 ETS64341.1 - 0.0016 18.3 0.0 0.062 13.2 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 ETS64341.1 - 0.1 12.4 0.0 2.1 8.3 0.0 2.6 3 0 0 3 3 3 0 Occluded RNA-recognition motif HMG_CoA_synt_C PF08540.10 ETS64342.1 - 9.2e-84 281.4 0.1 1.2e-83 280.9 0.1 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 ETS64342.1 - 3.7e-82 274.4 0.3 3.1e-78 261.6 0.2 2.5 2 0 0 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III_C PF08541.10 ETS64342.1 - 0.0046 17.1 0.0 0.053 13.7 0.0 2.5 2 1 1 3 3 3 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal Cu-oxidase_3 PF07732.15 ETS64343.1 - 4.3e-34 117.1 0.2 1e-33 115.9 0.2 1.7 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ETS64343.1 - 8.1e-31 106.6 2.9 1.7e-24 86.1 0.2 3.4 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 ETS64343.1 - 2.1e-15 57.2 0.0 2.7e-11 43.8 0.0 3.4 2 1 0 2 2 2 2 Multicopper oxidase Amidase PF01425.21 ETS64344.1 - 1.3e-99 334.2 0.0 4.4e-99 332.5 0.0 1.7 1 1 0 1 1 1 1 Amidase Pkinase PF00069.25 ETS64345.1 - 8.9e-41 140.0 0.0 1.3e-40 139.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64345.1 - 9.6e-15 54.6 0.0 1.8e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ETS64345.1 - 0.00017 21.2 0.0 0.00033 20.3 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ETS64345.1 - 0.15 10.8 0.0 0.32 9.7 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase TPR_1 PF00515.28 ETS64346.1 - 3.2e-24 83.7 0.2 8.7e-09 34.8 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETS64346.1 - 1.4e-19 69.4 1.8 6.6e-07 28.9 0.4 3.4 1 1 2 3 3 3 3 TPR repeat TPR_2 PF07719.17 ETS64346.1 - 5.1e-18 63.7 0.1 6.9e-07 28.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETS64346.1 - 5.8e-16 57.3 0.3 7.7e-06 25.7 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat Abhydrolase_2 PF02230.16 ETS64346.1 - 7.6e-13 48.8 0.0 1.5e-12 47.8 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase TPR_14 PF13428.6 ETS64346.1 - 1.9e-11 43.8 0.1 4.3e-05 24.0 0.0 4.3 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS64346.1 - 3.8e-10 40.1 0.3 1.6e-06 28.6 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS64346.1 - 2.4e-09 36.9 0.0 0.00016 21.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETS64346.1 - 1.1e-07 31.3 0.0 0.0002 21.2 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETS64346.1 - 4.1e-07 30.2 0.3 0.052 13.9 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS64346.1 - 6.5e-07 29.9 4.6 0.00065 20.3 0.2 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 ETS64346.1 - 8.3e-06 26.3 0.0 0.00066 20.1 0.0 2.4 2 0 0 2 2 2 1 Bacterial transcriptional activator domain SGTA_dimer PF16546.5 ETS64346.1 - 0.00013 21.7 0.1 0.00026 20.7 0.1 1.5 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_10 PF13374.6 ETS64346.1 - 0.00017 21.3 0.1 0.033 14.1 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETS64346.1 - 0.00055 20.4 1.1 6.2 7.7 0.1 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS64346.1 - 0.00076 19.6 0.0 0.15 12.2 0.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETS64346.1 - 0.0032 16.7 1.5 0.0078 15.5 0.0 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETS64346.1 - 0.011 15.8 1.5 4.5 7.4 0.0 2.9 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Alkyl_sulf_dimr PF14863.6 ETS64346.1 - 0.087 13.3 0.7 13 6.3 0.0 2.5 1 1 1 2 2 2 0 Alkyl sulfatase dimerisation STI1 PF17830.1 ETS64346.1 - 0.32 10.9 14.2 0.22 11.5 7.9 2.5 2 0 0 2 2 2 0 STI1 domain XPC-binding PF09280.11 ETS64346.1 - 0.43 10.4 6.5 0.22 11.3 3.8 2.0 2 0 0 2 2 1 0 XPC-binding domain RNase_H2_suC PF08615.11 ETS64347.1 - 1.6e-12 47.8 0.0 6.6e-12 45.8 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SAPS PF04499.15 ETS64347.1 - 0.25 10.1 2.5 0.3 9.8 2.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RPN2_C PF18004.1 ETS64347.1 - 1.2 9.1 8.4 1.8 8.5 8.4 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ETS64347.1 - 1.7 7.3 5.5 2.4 6.8 5.5 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETS64347.1 - 4.3 5.3 5.2 5.5 5.0 5.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM176 PF14851.6 ETS64347.1 - 4.5 6.9 6.9 7.8 6.2 6.9 1.4 1 0 0 1 1 1 0 FAM176 family HSP70 PF00012.20 ETS64348.1 - 4.9e-66 223.2 0.3 1.1e-65 222.0 0.3 1.6 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETS64348.1 - 1.3e-06 27.5 0.2 2.2e-06 26.8 0.2 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 ETS64348.1 - 0.0032 16.8 0.3 0.011 15.0 0.1 2.0 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase DDR PF08841.10 ETS64348.1 - 0.01 14.9 1.0 0.049 12.6 0.1 2.1 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain PilM_2 PF11104.8 ETS64348.1 - 0.026 13.5 0.0 0.53 9.3 0.0 2.2 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Actin PF00022.19 ETS64348.1 - 0.03 12.9 0.1 4.1 5.9 0.0 2.1 2 0 0 2 2 2 0 Actin US30 PF17624.2 ETS64348.1 - 0.088 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function MBOAT PF03062.19 ETS64350.1 - 9.9e-36 123.8 17.3 9.9e-36 123.8 17.3 2.0 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ETS64350.1 - 0.0008 19.6 3.1 0.0027 18.0 3.1 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Methyltransf_23 PF13489.6 ETS64351.1 - 5.7e-16 58.8 0.0 7.2e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS64351.1 - 6.3e-15 55.6 0.0 1.1e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS64351.1 - 4.4e-14 53.0 0.1 7.3e-14 52.2 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS64351.1 - 7e-14 52.4 0.1 1.1e-13 51.7 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS64351.1 - 2.4e-11 43.7 0.0 4.2e-11 42.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 ETS64351.1 - 1.3e-05 25.0 0.0 1.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Ubie_methyltran PF01209.18 ETS64351.1 - 2.7e-05 23.6 0.0 0.00013 21.4 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ETS64351.1 - 4.5e-05 23.1 0.0 6.7e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ETS64351.1 - 0.00015 21.3 0.1 0.00029 20.3 0.0 1.4 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) RrnaAD PF00398.20 ETS64351.1 - 0.00023 20.3 0.0 0.0003 20.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase tRNA_U5-meth_tr PF05958.11 ETS64351.1 - 0.0068 15.4 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase PCMT PF01135.19 ETS64351.1 - 0.015 15.0 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.11 ETS64351.1 - 0.02 14.5 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_4 PF02390.17 ETS64351.1 - 0.02 14.4 0.0 0.16 11.4 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase TehB PF03848.14 ETS64351.1 - 0.02 14.3 0.0 0.028 13.8 0.0 1.1 1 0 0 1 1 1 0 Tellurite resistance protein TehB DREV PF05219.12 ETS64351.1 - 0.083 12.0 0.0 0.14 11.2 0.0 1.5 2 0 0 2 2 2 0 DREV methyltransferase Methyltransf_18 PF12847.7 ETS64351.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PPR_2 PF13041.6 ETS64352.1 - 0.022 15.0 0.0 1.2 9.4 0.0 3.6 4 0 0 4 4 4 0 PPR repeat family TPR_12 PF13424.6 ETS64352.1 - 0.15 12.3 5.7 0.49 10.7 1.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETS64352.1 - 0.4 10.6 2.4 10 6.1 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Thioredoxin PF00085.20 ETS64353.1 - 7e-26 90.2 0.1 2.6e-25 88.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 ETS64353.1 - 1.6e-06 28.6 0.3 1.4e-05 25.5 0.1 2.8 1 1 1 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ETS64353.1 - 0.00058 19.3 0.1 0.0045 16.4 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 ETS64353.1 - 0.003 17.7 0.0 0.012 15.8 0.0 2.1 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 ETS64353.1 - 0.014 15.8 0.0 0.17 12.3 0.0 2.7 2 1 1 3 3 3 0 Thioredoxin-like Thioredoxin_9 PF14595.6 ETS64353.1 - 0.043 13.6 0.1 0.043 13.6 0.1 2.9 4 0 0 4 4 4 0 Thioredoxin Lactamase_B_2 PF12706.7 ETS64355.1 - 3.1e-31 108.5 0.5 9.7e-31 106.8 0.5 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ETS64355.1 - 6.4e-12 45.7 0.0 1.9e-11 44.1 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ETS64355.1 - 0.00055 20.0 0.0 0.0094 16.0 0.0 2.5 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Prenyltrans PF00432.21 ETS64356.1 - 2.2e-31 107.3 5.8 9.3e-07 28.5 0.0 6.3 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 ETS64356.1 - 0.0087 15.2 0.0 4.6 6.3 0.0 2.5 1 1 2 3 3 3 3 Squalene-hopene cyclase N-terminal domain Amidohydro_3 PF07969.11 ETS64357.1 - 5.9e-12 45.8 7.7 2.3e-05 24.0 0.7 3.5 3 0 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 ETS64357.1 - 4.6e-08 32.8 0.3 0.00068 19.0 0.0 2.8 3 0 0 3 3 3 2 Amidohydrolase family UNC-93 PF05978.16 ETS64358.1 - 6e-12 45.5 10.6 1.2e-11 44.6 8.8 2.2 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 ETS64358.1 - 1.4e-10 40.7 34.2 1.4e-10 40.7 34.2 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily zf-CCCH PF00642.24 ETS64359.1 - 2.5e-12 46.4 27.8 2e-06 27.5 2.5 4.7 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS64359.1 - 1.7e-07 31.1 28.3 0.029 14.4 4.3 4.6 4 0 0 4 4 4 3 Zinc finger domain Torus PF16131.5 ETS64359.1 - 0.023 15.4 18.2 0.054 14.2 0.1 4.9 3 1 1 5 5 5 0 Torus domain zf-CCCH_4 PF18044.1 ETS64359.1 - 0.025 14.4 2.1 0.025 14.4 2.1 4.9 5 0 0 5 5 5 0 CCCH-type zinc finger zf-CCCH_3 PF15663.5 ETS64359.1 - 7.4 6.8 19.1 1.1 9.5 1.1 3.4 1 1 1 3 3 3 0 Zinc-finger containing family DUF2235 PF09994.9 ETS64360.1 - 1.2e-66 225.0 0.0 1.2e-65 221.8 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF1917 PF08939.10 ETS64361.1 - 0.005 16.8 0.1 0.005 16.8 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF1917) Phage_holin_3_6 PF07332.11 ETS64362.1 - 0.007 16.4 1.7 0.007 16.4 1.7 2.2 2 0 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III His_Phos_1 PF00300.22 ETS64363.1 - 1.8e-37 129.0 0.0 2.1e-37 128.7 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ank_4 PF13637.6 ETS64364.1 - 2.8e-09 37.3 1.3 0.00096 19.7 0.2 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS64364.1 - 1.1e-07 32.3 0.9 0.022 15.3 0.1 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETS64364.1 - 3.4e-06 27.0 1.7 0.066 13.8 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeat KilA-N PF04383.13 ETS64364.1 - 1.5e-05 24.8 0.3 0.0002 21.2 0.3 2.2 1 1 0 1 1 1 1 KilA-N domain Ank_5 PF13857.6 ETS64364.1 - 7e-05 23.0 5.8 0.059 13.7 0.0 4.3 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 ETS64364.1 - 0.00089 19.6 7.9 0.53 10.8 0.6 4.4 4 0 0 4 4 4 2 Ankyrin repeat DUF4407 PF14362.6 ETS64364.1 - 0.042 13.2 9.9 0.13 11.6 9.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NYD-SP28 PF14772.6 ETS64364.1 - 0.17 12.0 5.6 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Sperm tail AAA_13 PF13166.6 ETS64364.1 - 3.3 6.2 6.4 4.8 5.7 6.4 1.1 1 0 0 1 1 1 0 AAA domain Rtf2 PF04641.12 ETS64366.1 - 2.5e-72 243.4 1.7 2.8e-72 243.3 1.7 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 ETS64366.1 - 0.005 16.6 1.4 0.1 12.5 0.0 2.7 2 1 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 ETS64366.1 - 0.03 14.4 0.0 0.079 13.1 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein RecR PF02132.15 ETS64366.1 - 0.069 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 RecR protein DUF2072 PF09845.9 ETS64366.1 - 0.41 10.9 5.4 0.83 9.9 5.4 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein RR_TM4-6 PF06459.12 ETS64366.1 - 0.64 9.8 7.9 0.97 9.2 7.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TAF4 PF05236.14 ETS64366.1 - 2 8.1 17.1 2.8 7.6 17.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family SHS2_Rpb7-N PF03876.17 ETS64367.1 - 1.1e-12 48.2 0.0 1.6e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ETS64367.1 - 3.1e-12 46.7 0.1 5.7e-12 45.8 0.1 1.4 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 ETS64367.1 - 0.05 13.8 0.1 0.08 13.2 0.1 1.4 1 1 0 1 1 1 0 RNA polymerase III subunit Rpc25 Ribonuc_P_40 PF08584.11 ETS64368.1 - 5.8e-30 104.5 0.0 3.2e-29 102.1 0.0 1.9 1 1 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit zf-RING_2 PF13639.6 ETS64369.1 - 3.9e-10 39.9 1.3 7.2e-10 39.0 1.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETS64369.1 - 8.6e-09 35.0 0.4 1.8e-08 34.0 0.4 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ETS64369.1 - 6.6e-07 29.1 0.6 1.2e-06 28.3 0.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS64369.1 - 9.3e-07 28.8 0.9 1.9e-06 27.8 0.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETS64369.1 - 1.5e-06 28.0 0.7 2.7e-06 27.2 0.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETS64369.1 - 1.1e-05 25.6 1.0 1.1e-05 25.6 1.0 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain FANCL_C PF11793.8 ETS64369.1 - 0.00068 19.8 0.7 0.0014 18.7 0.7 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4_3 PF13920.6 ETS64369.1 - 0.0023 17.7 0.4 0.0044 16.8 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETS64369.1 - 0.0029 17.2 1.0 0.006 16.2 0.2 1.9 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 ETS64369.1 - 0.0062 16.4 6.3 0.054 13.3 6.3 2.4 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETS64369.1 - 0.078 12.9 1.1 0.2 11.5 1.1 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETS64369.1 - 0.15 12.2 0.2 0.31 11.1 0.2 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Josephin PF02099.17 ETS64369.1 - 2.1 8.4 9.1 2.4 8.3 7.8 1.8 1 1 0 1 1 1 0 Josephin DUF3851 PF12962.7 ETS64369.1 - 2.3 8.5 4.6 1.8 8.9 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3851) Laminin_II PF06009.12 ETS64369.1 - 4.2 7.4 19.2 0.35 10.9 4.1 2.5 1 1 1 2 2 2 0 Laminin Domain II SYS1 PF09801.9 ETS64370.1 - 1.8e-24 86.5 4.8 7.3e-18 65.1 2.7 2.1 2 0 0 2 2 2 2 Integral membrane protein S linking to the trans Golgi network FMO-like PF00743.19 ETS64371.1 - 1.3e-34 119.5 0.0 7.3e-12 44.5 0.0 3.2 3 0 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ETS64371.1 - 1.1e-09 38.0 0.0 0.00011 21.5 0.0 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETS64371.1 - 9.3e-08 31.6 0.0 9.1e-07 28.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS64371.1 - 9.5e-06 25.8 0.1 0.0003 21.0 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ETS64371.1 - 3.6e-05 23.1 0.0 0.11 11.6 0.0 3.8 4 0 0 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ETS64371.1 - 9.6e-05 22.4 0.0 0.00045 20.2 0.0 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 ETS64371.1 - 0.0014 19.1 0.3 0.46 11.1 0.1 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETS64371.1 - 0.026 13.8 0.0 1.1 8.4 0.0 2.3 2 0 0 2 2 2 0 Thi4 family Shikimate_DH PF01488.20 ETS64371.1 - 0.049 13.7 0.2 0.69 10.0 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 ETS64371.1 - 0.078 12.5 0.0 0.49 9.9 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ETS64371.1 - 0.13 12.7 0.1 2.4 8.7 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding NAD_binding_8 PF13450.6 ETS64372.1 - 2.2e-11 43.8 0.0 5.7e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETS64372.1 - 0.0016 17.8 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ETS64372.1 - 0.0029 16.4 0.1 0.012 14.4 0.0 1.9 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 ETS64372.1 - 0.0034 16.6 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS64372.1 - 0.0053 16.4 0.1 0.055 13.0 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Terpene_synth_C PF03936.16 ETS64372.1 - 0.048 13.0 0.7 0.1 11.9 0.7 1.4 1 0 0 1 1 1 0 Terpene synthase family, metal binding domain NAD_binding_9 PF13454.6 ETS64372.1 - 0.086 12.8 0.0 0.29 11.1 0.0 1.9 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 ETS64372.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Sec7 PF01369.20 ETS64373.1 - 3.9e-33 114.7 0.0 5.7e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 Sec7 domain DUF4449 PF14613.6 ETS64374.1 - 3.7e-38 131.2 0.6 3.7e-38 131.2 0.6 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF4449) TPR_6 PF13174.6 ETS64374.1 - 0.038 14.6 1.1 18 6.2 0.0 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Sortilin-Vps10 PF15902.5 ETS64375.1 - 1.7e-286 950.0 0.8 1.1e-149 499.0 0.0 2.3 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 ETS64375.1 - 3e-91 304.3 15.2 8.6e-49 166.1 6.9 2.3 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 ETS64375.1 - 1.5e-08 33.3 42.1 1.8 8.9 0.0 11.7 11 0 0 11 11 11 5 BNR/Asp-box repeat BNR_2 PF13088.6 ETS64375.1 - 0.0041 16.5 5.0 0.47 9.7 0.1 4.8 4 1 1 5 5 5 1 BNR repeat-like domain Fe_dep_repr_C PF02742.15 ETS64375.1 - 0.023 14.8 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain F5_F8_type_C PF00754.25 ETS64375.1 - 0.023 14.8 2.0 2.8 8.1 0.0 5.2 6 1 1 7 7 7 0 F5/8 type C domain PSII_BNR PF14870.6 ETS64375.1 - 0.025 13.9 3.8 5.8 6.1 0.0 4.2 4 1 0 4 4 4 0 Photosynthesis system II assembly factor YCF48 BNR_6 PF15899.5 ETS64375.1 - 0.14 12.3 11.3 1.1 9.5 0.3 5.0 4 0 0 4 4 4 0 BNR-Asp box repeat SRF-TF PF00319.18 ETS64376.1 - 3.5e-21 74.4 0.0 5.5e-21 73.8 0.0 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) MS_channel PF00924.18 ETS64377.1 - 6.8e-22 78.0 1.4 1.2e-21 77.3 1.4 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 ETS64377.1 - 3.1e-06 26.3 0.1 6.3e-06 25.4 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETS64377.1 - 7e-05 22.4 0.0 0.00019 21.1 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETS64377.1 - 0.00031 21.1 0.2 0.00077 19.9 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETS64377.1 - 0.00067 19.0 0.1 0.0016 17.9 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 ETS64377.1 - 0.025 14.4 0.1 0.057 13.3 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain pair VIT1 PF01988.19 ETS64377.1 - 0.18 11.7 3.8 4 7.3 2.5 2.6 2 0 0 2 2 2 0 VIT family DUF1576 PF07613.11 ETS64377.1 - 8.9 5.8 10.1 0.086 12.4 0.5 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1576) Tubulin PF00091.25 ETS64378.1 - 3.9e-61 206.7 0.0 6e-61 206.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETS64378.1 - 3.9e-37 127.2 0.0 6.3e-37 126.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ETS64378.1 - 0.00099 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 ETS64378.1 - 0.0024 18.2 0.1 0.0064 16.8 0.0 1.8 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ETS64378.1 - 0.0036 16.5 0.0 0.0079 15.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin like Plug_translocon PF10559.9 ETS64379.1 - 0.033 14.0 0.0 0.067 13.1 0.0 1.6 1 0 0 1 1 1 0 Plug domain of Sec61p MFS_1 PF07690.16 ETS64381.1 - 1.7e-35 122.6 62.6 3.5e-35 121.6 56.9 3.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETS64381.1 - 2.1e-10 39.6 23.6 3.1e-10 39.1 23.6 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ETS64381.1 - 1.9e-08 33.6 9.7 1.9e-08 33.6 9.7 3.0 3 0 0 3 3 3 2 Sugar (and other) transporter Cellulose_synt PF03552.14 ETS64381.1 - 0.38 9.2 4.6 0.72 8.3 4.6 1.4 1 0 0 1 1 1 0 Cellulose synthase Elongin_A PF06881.11 ETS64383.1 - 0.13 12.8 0.0 0.27 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF3096 PF11295.8 ETS64384.1 - 0.25 11.0 2.8 0.58 9.9 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3096) STT3 PF02516.14 ETS64389.1 - 9.6e-142 473.3 35.8 4.7e-139 464.5 35.8 2.1 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit Pep3_Vps18 PF05131.14 ETS64390.1 - 1.2e-49 168.0 0.0 3.3e-49 166.5 0.0 1.8 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 ETS64390.1 - 3.8e-12 46.3 3.0 1.2e-06 28.5 0.1 3.1 2 1 0 2 2 2 2 Region in Clathrin and VPS Vps39_2 PF10367.9 ETS64390.1 - 0.00039 20.8 0.0 0.0013 19.1 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 DUF4249 PF14054.6 ETS64390.1 - 0.01 15.5 0.6 0.018 14.7 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) zf-RING_5 PF14634.6 ETS64390.1 - 0.012 15.6 2.3 0.012 15.6 2.3 1.8 2 0 0 2 2 2 0 zinc-RING finger domain DUF2175 PF09943.9 ETS64390.1 - 0.033 14.5 2.3 0.036 14.4 0.0 2.3 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) zf-RING_11 PF17123.5 ETS64390.1 - 0.079 12.7 5.3 0.17 11.6 5.3 1.6 1 0 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 ETS64390.1 - 0.13 11.9 1.7 0.28 10.8 1.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_2 PF13639.6 ETS64390.1 - 0.5 10.8 6.0 0.2 12.0 2.6 2.0 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETS64390.1 - 5.6 6.9 9.8 0.22 11.4 3.4 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MTP18 PF10558.9 ETS64391.1 - 7.6e-69 231.1 1.7 1.4e-68 230.2 1.7 1.4 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) Glyco_hydro_18 PF00704.28 ETS64392.1 - 7.9e-06 25.8 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 DUF3006 PF11213.8 ETS64392.1 - 0.041 14.1 0.0 0.088 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) Pkinase PF00069.25 ETS64393.1 - 3.1e-71 239.8 0.0 3.9e-71 239.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64393.1 - 6.8e-31 107.5 0.0 1.2e-30 106.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS64393.1 - 0.00035 20.0 0.0 0.0006 19.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ETS64393.1 - 0.0012 17.9 0.0 0.0078 15.2 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETS64393.1 - 0.0027 17.7 0.0 0.0088 16.0 0.0 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ETS64393.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Peptidase_S9_N PF02897.15 ETS64394.1 - 4.2e-83 279.5 2.6 5.8e-83 279.0 2.6 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 ETS64394.1 - 2.2e-50 171.1 0.1 3.4e-50 170.5 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AvrM_N PF18247.1 ETS64394.1 - 0.15 12.1 0.0 0.44 10.5 0.0 1.8 1 0 0 1 1 1 0 Flax-rust effector AvrM N-terminal domain DUF2974 PF11187.8 ETS64394.1 - 0.18 11.3 0.1 0.49 9.9 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) SAD_SRA PF02182.17 ETS64395.1 - 3.3e-55 186.1 0.0 8.9e-55 184.7 0.0 1.7 2 0 0 2 2 2 1 SAD/SRA domain Trypan_PARP PF05887.11 ETS64395.1 - 0.0034 17.4 6.7 0.0034 17.4 6.7 2.5 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) PBP1_TM PF14812.6 ETS64395.1 - 0.038 14.3 9.5 1.7 9.1 0.1 3.0 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vps5 PF09325.10 ETS64396.1 - 5.9e-68 228.9 5.7 5.9e-68 228.9 5.7 2.5 2 0 0 2 2 2 1 Vps5 C terminal like RmlD_sub_bind PF04321.17 ETS64396.1 - 8.7e-52 176.0 0.0 1.8e-51 174.9 0.0 1.6 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ETS64396.1 - 4.4e-23 82.0 0.0 1e-22 80.8 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PX PF00787.24 ETS64396.1 - 1.4e-22 79.8 0.0 2.7e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 PX domain GDP_Man_Dehyd PF16363.5 ETS64396.1 - 3.4e-10 39.8 0.0 3.4e-10 39.8 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ETS64396.1 - 1.9e-07 30.5 0.3 4e-06 26.2 0.3 2.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ETS64396.1 - 0.00086 18.5 0.0 0.00086 18.5 0.0 2.8 2 1 1 3 3 3 1 Male sterility protein DIL PF01843.19 ETS64396.1 - 0.027 14.7 0.1 0.061 13.6 0.1 1.5 1 0 0 1 1 1 0 DIL domain DUF572 PF04502.13 ETS64396.1 - 0.81 9.2 24.0 0.021 14.4 11.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) HAD_2 PF13419.6 ETS64397.1 - 8.5e-17 61.8 0.0 1.1e-12 48.4 0.0 2.3 1 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETS64397.1 - 4.1e-12 46.8 0.2 9.1e-11 42.4 0.0 2.5 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETS64397.1 - 0.002 18.6 0.0 0.0058 17.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS64397.1 - 0.048 13.7 0.0 0.69 10.0 0.0 2.7 3 1 0 3 3 3 0 HAD-hyrolase-like Hydrolase_6 PF13344.6 ETS64397.1 - 0.093 12.8 0.0 21 5.3 0.0 2.6 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Metallophos PF00149.28 ETS64398.1 - 2e-26 93.7 0.0 9.8e-26 91.5 0.0 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 ETS64398.1 - 2.4e-26 91.8 0.0 4.2e-26 91.1 0.0 1.4 1 0 0 1 1 1 1 PPP5 TPR repeat region TPR_1 PF00515.28 ETS64398.1 - 4e-11 42.2 2.0 0.00025 20.7 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETS64398.1 - 1e-08 34.6 2.1 0.024 14.7 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETS64398.1 - 9.1e-07 28.5 0.7 0.00066 19.3 0.2 2.9 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 ETS64398.1 - 0.00032 20.9 0.4 2.2 8.8 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS64398.1 - 0.00076 20.1 0.3 0.0017 19.0 0.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETS64398.1 - 0.0071 16.5 1.6 7.3 7.1 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat SR-25 PF10500.9 ETS64398.1 - 4.2 6.9 6.0 23 4.5 0.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein HMG_box_5 PF14887.6 ETS64399.1 - 0.014 15.3 0.3 0.048 13.6 0.3 1.9 1 0 0 1 1 1 0 HMG (high mobility group) box 5 BAR PF03114.18 ETS64400.1 - 5e-49 167.1 1.2 6.6e-49 166.7 1.2 1.1 1 0 0 1 1 1 1 BAR domain Jnk-SapK_ap_N PF09744.9 ETS64400.1 - 0.0013 19.0 1.2 0.24 11.6 1.4 2.5 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 AAA_13 PF13166.6 ETS64400.1 - 0.004 15.9 1.6 0.005 15.5 1.6 1.1 1 0 0 1 1 1 1 AAA domain Arfaptin PF06456.13 ETS64400.1 - 0.0046 16.6 2.8 0.0097 15.5 2.8 1.8 1 1 0 1 1 1 1 Arfaptin-like domain Sigma70_ner PF04546.13 ETS64400.1 - 0.029 14.3 0.2 0.029 14.3 0.2 2.6 1 1 2 3 3 3 0 Sigma-70, non-essential region Laminin_I PF06008.14 ETS64400.1 - 0.03 14.0 0.6 0.03 14.0 0.6 1.7 2 0 0 2 2 2 0 Laminin Domain I CdvA PF18822.1 ETS64400.1 - 0.044 13.6 1.8 0.11 12.3 0.2 2.5 3 0 0 3 3 3 0 CdvA-like coiled-coil domain BLOC1_2 PF10046.9 ETS64400.1 - 0.047 14.0 0.5 0.27 11.5 0.5 2.4 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.13 ETS64400.1 - 0.067 12.4 0.5 0.13 11.5 0.1 1.6 1 1 1 2 2 2 0 TMPIT-like protein HD_3 PF13023.6 ETS64400.1 - 0.077 12.9 0.4 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 HD domain Sec34 PF04136.15 ETS64400.1 - 0.08 12.8 0.4 0.22 11.4 0.2 1.9 2 0 0 2 2 2 0 Sec34-like family BAR_3 PF16746.5 ETS64400.1 - 0.086 12.5 1.4 0.38 10.4 1.1 2.2 1 1 1 2 2 2 0 BAR domain of APPL family IFT57 PF10498.9 ETS64400.1 - 0.14 11.1 1.9 0.12 11.4 0.6 1.6 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Golgin_A5 PF09787.9 ETS64400.1 - 0.17 11.3 3.6 0.059 12.8 1.0 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF948 PF06103.11 ETS64400.1 - 0.18 12.0 1.6 1.2 9.4 0.1 2.9 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF948) DivIC PF04977.15 ETS64400.1 - 0.3 10.9 2.8 0.31 10.8 0.8 2.1 2 0 0 2 2 2 0 Septum formation initiator GAS PF13851.6 ETS64400.1 - 0.93 8.8 4.6 0.5 9.7 0.5 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Seryl_tRNA_N PF02403.22 ETS64400.1 - 3.1 8.1 7.0 2.8 8.2 1.3 2.5 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain Snf7 PF03357.21 ETS64401.1 - 4.5e-49 166.4 14.3 5.4e-49 166.1 14.3 1.1 1 0 0 1 1 1 1 Snf7 NuA4 PF09340.10 ETS64401.1 - 0.0052 16.6 0.7 0.012 15.5 0.7 1.6 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Macoilin PF09726.9 ETS64401.1 - 0.029 12.9 3.9 0.035 12.7 3.9 1.0 1 0 0 1 1 1 0 Macoilin family Phasin PF05597.11 ETS64401.1 - 0.034 14.1 3.4 0.032 14.2 1.7 1.8 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Soyouz_module PF14313.6 ETS64401.1 - 0.067 13.0 0.0 16 5.4 0.0 2.7 2 0 0 2 2 2 0 N-terminal region of Paramyxovirinae phosphoprotein (P) Prefoldin_2 PF01920.20 ETS64401.1 - 0.14 12.1 10.8 4.5 7.3 0.0 3.3 2 1 0 2 2 2 0 Prefoldin subunit DUF848 PF05852.11 ETS64401.1 - 0.16 12.1 6.3 0.21 11.7 5.3 1.7 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) FlxA PF14282.6 ETS64401.1 - 0.18 11.8 11.2 0.037 14.0 6.6 2.1 1 1 1 2 2 2 0 FlxA-like protein CTNNBL PF08216.11 ETS64401.1 - 0.32 11.2 3.8 0.3 11.3 2.2 1.8 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear FlaC_arch PF05377.11 ETS64401.1 - 0.38 11.2 5.5 9.6 6.7 0.0 3.5 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) PEP-utilisers_N PF05524.13 ETS64401.1 - 0.42 10.8 10.9 0.08 13.1 2.8 2.5 1 1 1 2 2 2 0 PEP-utilising enzyme, N-terminal Prefoldin PF02996.17 ETS64401.1 - 0.45 10.4 9.8 11 6.0 1.2 3.4 4 0 0 4 4 4 0 Prefoldin subunit V_ATPase_I PF01496.19 ETS64401.1 - 0.66 7.8 6.5 0.81 7.5 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TBCA PF02970.16 ETS64401.1 - 1.5 9.2 7.8 5.5 7.4 7.8 2.0 1 0 0 1 1 1 0 Tubulin binding cofactor A NPV_P10 PF05531.12 ETS64401.1 - 2.3 8.7 7.1 3.6 8.1 0.1 3.4 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein BST2 PF16716.5 ETS64401.1 - 8.7 7.0 12.3 21 5.8 8.4 2.9 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Ssl1 PF04056.14 ETS64402.1 - 8.5e-68 228.0 0.0 1.3e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 ETS64402.1 - 2.9e-12 47.2 0.1 9.5e-12 45.5 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain DZR PF12773.7 ETS64402.1 - 0.52 10.4 6.2 2.2 8.4 6.2 1.9 1 1 0 1 1 1 0 Double zinc ribbon Tfb4 PF03850.14 ETS64402.1 - 2.9 7.3 6.1 51 3.2 5.5 2.7 2 1 0 3 3 3 0 Transcription factor Tfb4 Collagen PF01391.18 ETS64403.1 - 1.2e-06 28.1 24.4 1.2e-06 28.1 24.4 2.3 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) SWI-SNF_Ssr4 PF08549.10 ETS64403.1 - 9.4e-06 24.6 0.3 9.4e-06 24.6 0.3 3.1 2 1 0 2 2 2 1 Fungal domain of unknown function (DUF1750) Nop16 PF09420.10 ETS64403.1 - 6.8 6.7 10.7 0.26 11.3 2.1 2.2 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 Nop53 PF07767.11 ETS64404.1 - 3.6e-106 355.9 23.0 4.4e-106 355.6 23.0 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) MurB_C PF02873.16 ETS64404.1 - 0.086 12.9 0.5 0.19 11.8 0.5 1.6 1 0 0 1 1 1 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain DUF3106 PF11304.8 ETS64404.1 - 1.4 9.5 20.1 1.3 9.6 11.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) Ank_2 PF12796.7 ETS64405.1 - 3.8e-17 62.7 0.3 6.6e-15 55.5 1.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS64405.1 - 2.1e-16 60.0 4.0 2.7e-12 46.9 0.9 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETS64405.1 - 3.3e-13 48.5 0.6 5e-05 23.4 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETS64405.1 - 3.6e-12 46.1 4.4 8.2e-05 22.9 0.2 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETS64405.1 - 1.1e-11 44.7 2.8 4.7e-05 23.6 0.2 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Mt_ATP-synt_B PF05405.14 ETS64406.1 - 8.4e-45 152.3 9.4 9.9e-45 152.1 9.4 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) SLATT_1 PF18181.1 ETS64406.1 - 0.13 12.2 4.0 0.3 11.0 4.0 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 Cauli_DNA-bind PF03310.13 ETS64406.1 - 0.13 12.3 3.6 0.14 12.3 1.9 1.8 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein V_ATPase_I PF01496.19 ETS64406.1 - 4.3 5.1 7.2 5.3 4.8 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BCDHK_Adom3 PF10436.9 ETS64408.1 - 1e-66 223.8 0.0 1.4e-66 223.3 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ETS64408.1 - 3.9e-13 49.9 0.0 7.6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETS64408.1 - 7.2e-05 22.6 0.0 0.00016 21.5 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSF_DNA-bind PF00447.17 ETS64409.1 - 4.9e-31 107.2 1.3 7.9e-31 106.5 1.3 1.3 1 0 0 1 1 1 1 HSF-type DNA-binding HAP1_N PF04849.13 ETS64409.1 - 0.052 12.7 0.3 0.076 12.2 0.3 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region LBP_BPI_CETP PF01273.25 ETS64409.1 - 0.12 12.0 0.1 0.25 10.9 0.1 1.4 1 0 0 1 1 1 0 LBP / BPI / CETP family, N-terminal domain TPR_MLP1_2 PF07926.12 ETS64409.1 - 0.18 11.8 0.7 0.34 11.0 0.7 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 ETS64409.1 - 0.25 11.1 0.2 0.57 10.0 0.2 1.5 1 0 0 1 1 1 0 Septum formation initiator UPAR_LY6 PF00021.21 ETS64409.1 - 0.44 11.3 2.2 0.91 10.3 2.2 1.5 1 0 0 1 1 1 0 u-PAR/Ly-6 domain DPPIV_N PF00930.21 ETS64410.1 - 6.6e-76 255.4 0.0 1.4e-75 254.3 0.0 1.6 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ETS64410.1 - 9.4e-47 159.2 3.2 1.5e-46 158.6 3.2 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ETS64410.1 - 3.3e-06 26.9 4.4 1.7e-05 24.6 3.9 2.4 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) AXE1 PF05448.12 ETS64410.1 - 6.8e-06 25.0 0.0 0.00065 18.5 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 ETS64410.1 - 1.3e-05 26.0 0.5 1.3e-05 26.0 0.5 2.9 3 1 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETS64410.1 - 9e-05 22.2 0.1 0.00018 21.2 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 ETS64410.1 - 0.032 13.7 2.7 0.022 14.3 0.5 1.8 2 0 0 2 2 2 0 Esterase PHB depolymerase Hydrolase_4 PF12146.8 ETS64410.1 - 0.052 12.8 0.3 0.38 10.0 0.1 2.1 1 1 0 2 2 2 0 Serine aminopeptidase, S33 DLH PF01738.18 ETS64410.1 - 0.063 12.8 0.1 0.18 11.3 0.1 1.7 1 1 0 1 1 1 0 Dienelactone hydrolase family BAAT_C PF08840.11 ETS64410.1 - 0.1 12.5 0.0 10 6.0 0.0 2.2 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal MFS_1 PF07690.16 ETS64411.1 - 1.1e-22 80.4 35.2 2.5e-17 62.9 12.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 ETS64411.1 - 7.2 4.7 12.2 0.22 9.7 1.0 2.9 3 1 1 4 4 4 0 BT1 family E1-E2_ATPase PF00122.20 ETS64412.1 - 7.4e-30 103.8 0.2 1.5e-29 102.8 0.2 1.5 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 ETS64412.1 - 1.6e-27 96.1 0.0 5.9e-27 94.2 0.0 2.0 1 1 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 ETS64412.1 - 2e-18 67.4 0.0 4.6e-10 40.1 0.0 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS64412.1 - 2.1e-05 24.5 0.0 5.1e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ETS64412.1 - 2.8e-05 23.7 0.0 5e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF5463 PF17551.2 ETS64412.1 - 0.12 12.3 0.5 0.3 11.0 0.5 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5463) AA_permease PF00324.21 ETS64413.1 - 1.2e-100 337.5 43.8 1.4e-100 337.1 43.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS64413.1 - 2e-26 92.8 48.3 2.5e-26 92.5 48.3 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1198 PF06711.11 ETS64413.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1198) RA PF00788.23 ETS64414.1 - 1.9e-13 50.9 0.0 3.3e-13 50.1 0.0 1.3 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SH3_1 PF00018.28 ETS64414.1 - 3.8e-13 48.8 0.3 3.5e-08 32.9 0.1 2.7 2 0 0 2 2 2 2 SH3 domain SAM_1 PF00536.30 ETS64414.1 - 6.3e-13 49.0 0.0 1.3e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETS64414.1 - 2.2e-12 46.9 0.0 3.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 ETS64414.1 - 1e-10 41.3 1.1 4.9e-06 26.3 0.1 3.0 2 0 0 2 2 2 2 Variant SH3 domain SAM_4 PF18017.1 ETS64414.1 - 0.21 11.5 0.1 0.53 10.3 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2205 PF10224.9 ETS64415.1 - 0.044 13.8 0.0 0.097 12.7 0.0 1.5 1 0 0 1 1 1 0 Short coiled-coil protein TF_Zn_Ribbon PF08271.12 ETS64416.1 - 5.2e-05 22.7 0.9 0.0001 21.7 0.9 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding Zn_Tnp_IS1595 PF12760.7 ETS64416.1 - 0.012 15.6 0.1 0.031 14.2 0.1 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 ETS64416.1 - 0.14 12.2 1.4 0.26 11.3 1.4 1.5 1 0 0 1 1 1 0 PhnA Zinc-Ribbon DZR PF12773.7 ETS64416.1 - 0.16 12.0 0.4 0.34 11.0 0.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 ETS64416.1 - 0.86 9.1 4.6 16 5.1 4.6 2.3 1 1 0 1 1 1 0 zinc-ribbon domain zf-IS66 PF13005.7 ETS64416.1 - 1.2 9.6 3.3 4.7 7.7 0.2 2.7 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 Baculo_PP31 PF05311.11 ETS64416.1 - 3.2 7.1 7.9 0.59 9.6 4.3 1.6 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) ADH_N PF08240.12 ETS64417.1 - 9.7e-27 93.0 0.9 1.5e-26 92.4 0.9 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS64417.1 - 6.1e-09 35.9 0.0 0.00025 21.0 0.0 2.5 1 1 1 2 2 2 2 Zinc-binding dehydrogenase ADH_N_assoc PF13823.6 ETS64417.1 - 1.1e-07 31.6 0.0 1.1e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-associated 2-Hacid_dh_C PF02826.19 ETS64417.1 - 0.0011 18.3 0.0 0.003 16.9 0.0 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 ETS64417.1 - 0.0013 19.0 0.0 0.0024 18.1 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ADH_zinc_N_2 PF13602.6 ETS64417.1 - 0.0026 18.8 0.1 0.031 15.3 0.1 2.3 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ApbA PF02558.16 ETS64417.1 - 0.0032 17.1 0.0 0.048 13.3 0.0 2.4 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA PPL4 PF18188.1 ETS64417.1 - 0.064 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Prim-pol 4 Shikimate_DH PF01488.20 ETS64417.1 - 0.065 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Cation_ATPase_C PF00689.21 ETS64419.1 - 0.0083 15.9 3.9 0.014 15.1 3.9 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus EVC2_like PF12297.8 ETS64419.1 - 0.017 13.8 0.2 0.023 13.4 0.2 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein HemY_N PF07219.13 ETS64419.1 - 1.8 8.8 13.1 0.18 12.0 1.6 2.4 1 1 1 2 2 2 0 HemY protein N-terminus TctB PF07331.11 ETS64419.1 - 4.1 7.7 14.2 6.5 7.0 14.1 1.5 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Sugar_tr PF00083.24 ETS64420.1 - 1.9e-21 76.5 24.6 3.2e-20 72.4 24.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter DAO PF01266.24 ETS64422.1 - 8.6e-62 209.7 1.6 9.7e-62 209.6 1.6 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS64422.1 - 2e-08 33.8 1.1 0.00097 18.4 0.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETS64422.1 - 5.8e-06 26.8 0.7 0.0078 16.8 0.2 2.7 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS64422.1 - 0.00045 19.4 7.4 0.0015 17.7 7.4 1.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ETS64422.1 - 0.00063 19.9 1.3 0.0018 18.5 0.8 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 ETS64422.1 - 0.0019 16.9 0.5 0.14 10.7 0.0 2.1 2 0 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) GMC_oxred_N PF00732.19 ETS64422.1 - 0.0021 17.5 0.4 0.025 14.0 0.0 2.1 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_3 PF01494.19 ETS64422.1 - 0.0095 15.2 0.8 0.18 11.0 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain Trp_halogenase PF04820.14 ETS64422.1 - 0.01 14.7 0.8 0.32 9.8 0.8 2.1 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_9 PF13454.6 ETS64422.1 - 0.015 15.3 0.8 3 7.8 0.2 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 ETS64422.1 - 0.037 13.2 0.7 2.2 7.3 0.2 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.18 ETS64422.1 - 0.11 12.7 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain GIDA PF01134.22 ETS64422.1 - 0.14 11.2 3.5 2.2 7.3 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 ETS64422.1 - 0.22 10.8 5.2 0.56 9.5 5.2 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase ApbA PF02558.16 ETS64422.1 - 0.27 10.8 2.4 0.25 11.0 0.9 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Sacchrp_dh_NADP PF03435.18 ETS64422.1 - 0.31 11.3 1.8 0.5 10.6 0.1 2.2 3 0 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain MCRA PF06100.11 ETS64422.1 - 1 8.1 3.4 1.1 8.0 0.1 2.0 2 0 0 2 2 2 0 MCRA family Histone PF00125.24 ETS64423.1 - 6.5e-40 136.5 0.0 8.2e-40 136.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ETS64423.1 - 0.0067 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 ETS64423.1 - 0.095 13.1 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 CENP-S protein ADIP PF11559.8 ETS64424.1 - 2.6e-26 92.5 7.2 2.6e-26 92.5 7.2 4.5 3 1 1 4 4 4 1 Afadin- and alpha -actinin-Binding Shugoshin_N PF07558.11 ETS64424.1 - 3 7.8 9.5 9.5 6.2 0.2 3.5 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region Dabb PF07876.12 ETS64425.1 - 2.9e-18 66.3 0.1 3.2e-18 66.1 0.1 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain NAD_binding_10 PF13460.6 ETS64426.1 - 1.7e-09 37.8 0.5 4.5e-09 36.5 0.1 1.9 2 1 0 2 2 2 1 NAD(P)H-binding ABC2_membrane PF01061.24 ETS64427.1 - 1.6e-65 220.5 48.0 1.5e-36 125.8 18.0 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 ETS64427.1 - 3.5e-37 128.0 0.1 2.7e-18 66.8 0.0 3.2 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 ETS64427.1 - 3.4e-21 75.0 6.0 6.3e-20 70.9 0.0 3.5 3 0 0 3 3 3 1 CDR ABC transporter AAA_16 PF13191.6 ETS64427.1 - 4.7e-07 30.3 1.3 0.00065 20.1 0.4 2.7 2 0 0 2 2 2 2 AAA ATPase domain ABC_trans_N PF14510.6 ETS64427.1 - 1.7e-06 28.5 0.0 4.1e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_29 PF13555.6 ETS64427.1 - 5.5e-05 22.8 2.4 0.027 14.2 0.4 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 ETS64427.1 - 6.1e-05 23.0 1.2 0.2 11.4 0.1 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ETS64427.1 - 0.00019 22.0 0.1 0.09 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ETS64427.1 - 0.00027 20.6 0.2 0.0031 17.1 0.2 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETS64427.1 - 0.00058 20.1 0.6 0.47 10.7 0.2 2.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETS64427.1 - 0.00066 19.6 0.8 0.0086 16.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase SMC_N PF02463.19 ETS64427.1 - 0.006 16.0 0.0 2 7.8 0.0 3.1 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ETS64427.1 - 0.0093 16.0 0.7 3.2 7.9 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ETS64427.1 - 0.041 14.4 0.6 0.34 11.4 0.1 2.5 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 ETS64427.1 - 0.06 13.5 0.9 0.94 9.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_17 PF13207.6 ETS64427.1 - 0.075 13.5 0.7 7.3 7.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.9 ETS64427.1 - 0.12 11.1 0.4 0.31 9.8 0.4 1.6 1 0 0 1 1 1 0 Predicted ATPase of the ABC class DnaB_C PF03796.15 ETS64427.1 - 0.16 11.3 0.2 3.2 7.0 0.2 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Rad51 PF08423.11 ETS64427.1 - 0.19 11.0 0.0 0.34 10.1 0.0 1.3 1 0 0 1 1 1 0 Rad51 ATPase PF06745.13 ETS64427.1 - 0.62 9.4 2.7 1.7 8.0 0.5 2.4 3 0 0 3 3 3 0 KaiC cobW PF02492.19 ETS64427.1 - 1.1 8.8 2.7 3.1 7.4 0.8 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Fungal_trans PF04082.18 ETS64428.1 - 5.2e-19 68.3 0.0 9.7e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain adh_short_C2 PF13561.6 ETS64429.1 - 1.1e-57 195.3 1.5 1.2e-57 195.1 1.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS64429.1 - 1.1e-42 145.8 1.8 1.4e-42 145.4 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS64429.1 - 2.7e-11 43.7 0.5 3.9e-11 43.2 0.5 1.2 1 0 0 1 1 1 1 KR domain S4 PF01479.25 ETS64429.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 S4 domain SBP_bac_11 PF13531.6 ETS64429.1 - 0.11 12.2 0.6 0.27 10.9 0.6 1.8 1 1 0 1 1 1 0 Bacterial extracellular solute-binding protein ox_reductase_C PF08635.10 ETS64430.1 - 3.4e-50 169.4 0.0 6.3e-50 168.5 0.0 1.4 2 0 0 2 2 2 1 Putative oxidoreductase C terminal domain GFO_IDH_MocA_C PF02894.17 ETS64430.1 - 1.4e-06 28.3 0.0 3.3e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Carla_C4 PF01623.17 ETS64431.1 - 0.56 10.2 4.8 15 5.7 1.9 2.1 1 1 1 2 2 2 0 Carlavirus putative nucleic acid binding protein Calici_coat_C PF08435.11 ETS64433.1 - 0.035 13.6 0.2 0.054 13.0 0.2 1.4 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal Questin_oxidase PF14027.6 ETS64434.1 - 2.6e-70 237.6 0.6 3.4e-70 237.3 0.6 1.1 1 0 0 1 1 1 1 Questin oxidase-like 8TM_micro PF17028.5 ETS64435.1 - 0.17 11.6 0.0 0.24 11.1 0.0 1.1 1 0 0 1 1 1 0 8TM Microsporidial transmembrane domain p450 PF00067.22 ETS64436.1 - 6.1e-34 117.6 0.0 4e-32 111.6 0.0 2.7 2 1 0 2 2 2 2 Cytochrome P450 DUF1184 PF06683.11 ETS64436.1 - 0.27 10.7 0.0 0.46 9.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1184) MFS_1 PF07690.16 ETS64437.1 - 2.7e-44 151.6 32.0 2.7e-44 151.6 32.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64437.1 - 2.3e-10 40.0 7.4 2.3e-10 40.0 7.4 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ETS64437.1 - 4.4e-06 25.4 2.0 7.5e-06 24.6 2.0 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) PDGLE PF13190.6 ETS64437.1 - 0.06 13.2 0.5 0.5 10.3 0.0 2.6 2 0 0 2 2 2 0 PDGLE domain OATP PF03137.20 ETS64437.1 - 0.46 8.7 6.7 0.18 10.1 3.0 2.2 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family TraW_N PF12477.8 ETS64437.1 - 1.8 8.6 6.8 4.5 7.4 0.1 4.0 3 0 0 3 3 3 0 Sex factor F TraW protein N terminal Myb_DNA-binding PF00249.31 ETS64438.1 - 1.4e-28 98.8 9.6 6.9e-14 51.8 0.1 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETS64438.1 - 5.2e-28 97.1 4.4 7.5e-14 51.7 0.0 3.3 2 1 1 3 3 3 3 Myb-like DNA-binding domain Rap1_C PF11626.8 ETS64438.1 - 0.0033 17.5 3.0 0.25 11.4 0.0 3.3 2 1 1 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.9 ETS64438.1 - 0.0038 17.5 2.1 1.5 9.2 0.0 3.4 3 0 0 3 3 3 2 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 ETS64438.1 - 0.024 15.0 10.1 0.1 13.0 0.8 3.3 2 1 1 3 3 3 0 Myb/SANT-like DNA-binding domain Myb_DNA-bind_5 PF13873.6 ETS64438.1 - 0.19 11.8 3.6 0.26 11.4 0.3 2.9 2 2 0 2 2 2 0 Myb/SANT-like DNA-binding domain Atg29_N PF18388.1 ETS64438.1 - 0.57 10.0 2.5 10 6.1 0.3 3.0 2 1 0 2 2 2 0 Atg29 N-terminal domain FAD_binding_3 PF01494.19 ETS64439.1 - 2.1e-15 56.8 3.4 6e-14 52.0 3.4 2.5 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETS64439.1 - 3.8e-10 39.9 4.7 1.5e-05 24.8 0.3 2.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ETS64439.1 - 3.5e-07 29.9 1.0 0.0064 15.8 0.0 3.1 3 0 0 3 3 3 3 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 ETS64439.1 - 6.4e-07 28.9 0.3 0.024 13.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS64439.1 - 6.9e-06 25.4 1.2 0.013 14.6 0.3 2.3 2 0 0 2 2 2 2 FAD binding domain HI0933_like PF03486.14 ETS64439.1 - 0.00044 19.1 0.3 0.32 9.6 0.1 2.3 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_8 PF13450.6 ETS64439.1 - 0.00066 19.9 0.1 0.002 18.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 ETS64439.1 - 0.0013 17.7 1.9 0.35 9.7 0.2 2.8 3 0 0 3 3 3 2 Tryptophan halogenase Pyr_redox PF00070.27 ETS64439.1 - 0.0016 19.0 0.3 0.024 15.2 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 ETS64439.1 - 0.0017 17.5 0.0 1 8.3 0.0 2.1 2 0 0 2 2 2 2 Squalene epoxidase Pyr_redox_3 PF13738.6 ETS64439.1 - 0.011 15.0 0.1 3.9 6.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS64439.1 - 0.042 12.9 1.4 4 6.4 0.4 2.4 2 0 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 ETS64439.1 - 0.13 11.5 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 Thi4 family TrkA_N PF02254.18 ETS64439.1 - 0.14 12.4 0.0 0.48 10.7 0.0 1.9 1 0 0 1 1 1 0 TrkA-N domain Aldo_ket_red PF00248.21 ETS64440.1 - 5.6e-44 150.5 0.0 1.3e-43 149.3 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Zein-binding PF04576.15 ETS64440.1 - 0.099 12.9 0.5 24 5.3 0.1 2.8 3 0 0 3 3 3 0 Zein-binding Pox_I6 PF04595.13 ETS64440.1 - 0.19 10.7 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus I6-like family ketoacyl-synt PF00109.26 ETS64441.1 - 1.9e-47 162.0 0.2 1.9e-47 162.0 0.2 2.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 ETS64441.1 - 8.7e-21 74.7 2.3 1.6e-20 73.9 2.3 1.4 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Ketoacyl-synt_C PF02801.22 ETS64441.1 - 1.5e-13 50.8 0.2 5.8e-13 48.9 0.2 2.0 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 ETS64441.1 - 0.015 15.7 0.1 0.079 13.4 0.1 2.3 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension UBA_6 PF18039.1 ETS64441.1 - 0.18 11.8 0.0 0.96 9.4 0.0 2.1 2 0 0 2 2 2 0 UBA-like domain Lactamase_B_2 PF12706.7 ETS64442.1 - 3.4e-27 95.3 0.0 4.8e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ETS64442.1 - 2.4e-05 24.5 0.1 3.9e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ETS64442.1 - 0.0063 16.0 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Sel1 PF08238.12 ETS64443.1 - 2.5e-14 53.4 3.2 0.0015 19.2 0.1 5.3 6 0 0 6 6 6 3 Sel1 repeat TPR_12 PF13424.6 ETS64443.1 - 0.69 10.2 5.2 9.4 6.6 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4129 PF13559.6 ETS64443.1 - 8.7 6.7 11.8 2.2 8.6 0.1 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4129) Ipi1_N PF12333.8 ETS64444.1 - 2.7e-16 60.0 0.5 6.4e-15 55.6 0.0 3.4 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation HEAT_EZ PF13513.6 ETS64444.1 - 0.027 15.0 1.4 0.11 13.0 0.0 2.9 3 0 0 3 3 3 0 HEAT-like repeat Complex1_LYR PF05347.15 ETS64445.1 - 0.52 10.4 4.5 0.43 10.7 2.1 2.2 2 1 0 2 2 2 0 Complex 1 protein (LYR family) eIF2A PF08662.11 ETS64446.1 - 7.2e-40 136.9 0.0 1.1e-34 120.1 0.0 4.4 3 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 ETS64446.1 - 1.5e-05 24.7 0.1 3.6e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_32 PF13654.6 ETS64446.1 - 0.085 11.6 6.5 0.13 11.0 6.5 1.2 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 ETS64446.1 - 0.098 13.6 6.7 1.5 9.8 0.1 5.0 7 0 0 7 7 7 0 WD domain, G-beta repeat ApoLp-III PF07464.11 ETS64446.1 - 0.43 10.7 3.1 0.8 9.8 3.1 1.5 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) 4HB_MCP_1 PF12729.7 ETS64446.1 - 0.68 9.5 7.8 1.1 8.7 7.8 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Metal_resist PF13801.6 ETS64446.1 - 0.68 10.1 10.7 1.7 8.9 0.2 2.5 1 1 1 2 2 2 0 Heavy-metal resistance YtxH PF12732.7 ETS64446.1 - 2.6 8.7 4.8 45 4.7 4.8 2.7 1 1 0 1 1 1 0 YtxH-like protein Spb1_C PF07780.12 ETS64447.1 - 1.9e-80 269.5 22.1 1.9e-80 269.5 22.1 4.2 4 1 0 4 4 4 1 Spb1 C-terminal domain FtsJ PF01728.19 ETS64447.1 - 4.1e-55 186.6 0.1 1.8e-54 184.5 0.0 2.0 2 0 0 2 2 2 1 FtsJ-like methyltransferase DUF3381 PF11861.8 ETS64447.1 - 4.5e-47 159.9 9.5 4.5e-47 159.9 9.5 5.8 4 2 1 5 5 5 1 Domain of unknown function (DUF3381) DUF148 PF02520.17 ETS64447.1 - 0.087 12.9 5.1 0.082 13.0 1.7 2.6 2 0 0 2 2 2 0 Domain of unknown function DUF148 DUF1751 PF08551.10 ETS64448.1 - 3e-28 98.3 3.8 7.1e-28 97.1 3.8 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) AWPM-19 PF05512.11 ETS64448.1 - 0.038 14.2 0.6 0.038 14.2 0.6 1.7 2 0 0 2 2 2 0 AWPM-19-like family Rhomboid PF01694.22 ETS64448.1 - 0.25 11.4 9.6 0.08 12.9 6.3 1.9 1 1 1 2 2 2 0 Rhomboid family LRR_6 PF13516.6 ETS64449.1 - 6.8e-10 38.2 14.3 0.25 11.5 0.0 7.4 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 ETS64449.1 - 3.4e-05 24.1 17.1 0.056 13.9 2.1 6.4 4 2 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETS64449.1 - 0.00038 20.6 5.1 8.5 7.4 0.0 6.3 7 1 0 7 7 7 1 Leucine Rich Repeat Mlh1_C PF16413.5 ETS64449.1 - 0.15 11.4 0.4 0.24 10.7 0.4 1.2 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus LRR_8 PF13855.6 ETS64449.1 - 0.15 11.8 15.0 0.29 10.9 0.1 5.4 5 1 0 5 5 5 0 Leucine rich repeat GCIP PF13324.6 ETS64449.1 - 5.2 6.6 9.4 11 5.6 9.4 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting GTP_EFTU PF00009.27 ETS64450.1 - 8.7e-67 224.4 0.2 1.3e-66 223.9 0.2 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ETS64450.1 - 3.6e-32 110.7 0.0 9.9e-32 109.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ETS64450.1 - 1.8e-21 75.9 0.0 4.1e-21 74.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETS64450.1 - 4.8e-14 52.5 0.0 1.3e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ETS64450.1 - 1.7e-13 50.4 0.0 4.4e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ETS64450.1 - 2e-05 24.6 0.1 4.1e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Lectin_N PF03954.14 ETS64452.1 - 0.0018 18.0 2.4 0.0077 16.0 0.3 2.5 1 1 1 2 2 2 1 Hepatic lectin, N-terminal domain HOOK PF05622.12 ETS64452.1 - 0.017 13.3 3.8 0.025 12.7 3.8 1.2 1 0 0 1 1 1 0 HOOK protein Tho2 PF11262.8 ETS64452.1 - 0.03 13.5 0.2 0.049 12.8 0.2 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Imm71 PF15602.6 ETS64452.1 - 0.08 13.0 0.6 0.2 11.7 0.6 1.7 1 0 0 1 1 1 0 Immunity protein 71 Nre_C PF04895.12 ETS64452.1 - 0.084 12.8 1.0 0.15 12.0 0.2 1.8 2 0 0 2 2 2 0 Archaeal Nre, C-terminal Spc7 PF08317.11 ETS64452.1 - 0.089 11.7 7.4 0.18 10.7 7.4 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein FAP206 PF12018.8 ETS64452.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function WD40 PF00400.32 ETS64453.1 - 6.3e-17 61.6 9.5 0.00091 20.0 0.3 7.4 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64453.1 - 2.1e-05 24.7 0.0 3.2 8.1 0.0 5.7 4 2 3 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETS64453.1 - 0.00025 19.9 0.0 0.21 10.3 0.0 2.9 2 0 0 2 2 2 2 Nup133 N terminal like HemX PF04375.14 ETS64454.1 - 0.0012 18.3 0.2 0.0013 18.1 0.2 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase PEX11 PF05648.14 ETS64455.1 - 1.5e-67 227.3 2.8 1.7e-67 227.1 2.8 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Zn_clus PF00172.18 ETS64456.1 - 5.5e-06 26.4 15.3 1.1e-05 25.5 15.3 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Tautomerase_3 PF14832.6 ETS64457.1 - 7.2e-42 142.9 0.0 8.3e-42 142.7 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme RNA_pol_Rpb6 PF01192.22 ETS64458.1 - 3.6e-18 65.2 0.1 5.3e-18 64.7 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 adh_short PF00106.25 ETS64459.1 - 6.5e-23 81.2 0.0 1.9e-21 76.5 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS64459.1 - 1.3e-18 67.4 0.0 1.8e-17 63.7 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 ETS64459.1 - 0.039 13.8 0.0 0.063 13.1 0.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain His_Phos_2 PF00328.22 ETS64460.1 - 1.4e-46 159.6 0.0 2.1e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) MFS_1 PF07690.16 ETS64461.1 - 7.1e-29 100.8 41.4 1.2e-28 100.1 41.4 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Epimerase PF01370.21 ETS64462.1 - 4e-10 39.6 0.1 5.2e-09 35.9 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETS64462.1 - 2.9e-07 29.9 0.0 0.0031 16.7 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 ETS64462.1 - 8e-07 28.3 0.0 2e-06 27.0 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ETS64462.1 - 0.00025 20.6 0.1 0.00072 19.0 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ETS64462.1 - 0.00033 20.6 0.5 0.00057 19.8 0.4 1.7 2 1 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 ETS64462.1 - 0.0019 17.8 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ETS64462.1 - 0.0077 15.7 0.2 0.05 13.0 0.0 2.0 2 0 0 2 2 2 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ETS64462.1 - 0.012 14.8 0.0 0.27 10.3 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ETS64462.1 - 0.013 14.6 0.1 0.17 10.9 0.0 2.4 3 0 0 3 3 3 0 RmlD substrate binding domain KR PF08659.10 ETS64462.1 - 0.029 14.3 0.4 0.087 12.7 0.4 1.7 1 1 0 1 1 1 0 KR domain Zn_clus PF00172.18 ETS64463.1 - 6.4e-07 29.4 10.6 1.3e-06 28.4 10.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ribo_biogen_C PF04034.13 ETS64465.1 - 4.5e-48 162.2 0.0 6.3e-48 161.7 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 ETS64465.1 - 2.5e-15 56.0 0.1 4.1e-15 55.3 0.1 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI RNA_polI_A34 PF08208.11 ETS64465.1 - 1.2 9.2 8.9 8.3 6.4 0.1 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 SpoIIIAH PF12685.7 ETS64465.1 - 1.4 8.7 10.3 0.05 13.4 4.0 1.7 2 0 0 2 2 2 0 SpoIIIAH-like protein NPR3 PF03666.13 ETS64465.1 - 1.5 7.5 7.4 2.7 6.7 7.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SDA1 PF05285.12 ETS64465.1 - 5.1 6.4 20.6 0.032 13.7 8.1 2.1 2 0 0 2 2 2 0 SDA1 ICL PF00463.21 ETS64466.1 - 1.7e-255 848.5 0.8 2e-255 848.2 0.8 1.1 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 ETS64466.1 - 5.3e-09 35.9 0.0 1.1e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Ntox1 PF15500.6 ETS64466.1 - 0.12 12.8 0.1 0.44 10.9 0.1 2.0 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 Arg_repressor_C PF02863.18 ETS64466.1 - 0.18 11.7 0.1 0.42 10.5 0.1 1.6 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain ABC2_membrane PF01061.24 ETS64467.1 - 5.1e-44 150.2 19.8 8.4e-44 149.5 19.8 1.4 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ETS64467.1 - 1.1e-22 81.0 0.0 1.9e-22 80.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 ETS64467.1 - 6.4e-05 22.2 14.5 6.4e-05 22.2 14.5 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_21 PF13304.6 ETS64467.1 - 0.001 18.9 0.6 1.1 9.0 0.0 2.4 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ETS64467.1 - 0.0019 18.6 0.5 0.0052 17.2 0.1 1.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETS64467.1 - 0.0029 17.9 0.0 0.18 12.1 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.6 ETS64467.1 - 0.0059 16.2 0.1 0.019 14.6 0.0 1.9 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ETS64467.1 - 0.019 15.5 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETS64467.1 - 0.025 14.5 0.1 0.047 13.6 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_28 PF13521.6 ETS64467.1 - 0.039 14.2 0.0 0.072 13.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETS64467.1 - 0.13 12.1 0.2 0.31 10.8 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ETS64467.1 - 0.16 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase BTB PF00651.31 ETS64468.1 - 7e-09 35.9 0.0 0.00024 21.3 0.0 2.3 2 0 0 2 2 2 2 BTB/POZ domain CWC25 PF12542.8 ETS64469.1 - 9.3e-26 90.7 0.9 9.3e-26 90.7 0.9 4.4 3 1 0 4 4 4 1 Pre-mRNA splicing factor Cir_N PF10197.9 ETS64469.1 - 1e-12 48.0 13.3 1e-12 48.0 13.3 5.1 5 0 0 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR RNA_pol_Rpb2_6 PF00562.28 ETS64470.1 - 4.3e-125 417.8 0.4 8.9e-125 416.8 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ETS64470.1 - 1e-65 221.1 0.0 1.5e-65 220.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 ETS64470.1 - 3.1e-49 167.2 0.0 8.3e-49 165.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 ETS64470.1 - 1.6e-30 105.4 0.1 7.3e-30 103.2 0.1 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 ETS64470.1 - 8.6e-25 86.7 0.1 2.4e-24 85.3 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 ETS64470.1 - 3.7e-23 81.6 1.3 7e-23 80.7 0.4 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 ETS64470.1 - 2.9e-20 72.6 0.4 9.4e-20 70.9 0.4 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Acetyltransf_1 PF00583.25 ETS64472.1 - 9.4e-08 32.3 0.0 1.2e-07 31.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ETS64472.1 - 4.4e-07 29.8 0.0 7.4e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ETS64472.1 - 2e-06 27.8 0.0 2.7e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETS64472.1 - 9.8e-05 22.7 0.1 0.00019 21.8 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETS64472.1 - 0.0023 18.0 0.2 0.0037 17.3 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Prenyltrans PF00432.21 ETS64473.1 - 1.1e-48 162.6 9.1 7.2e-11 41.6 0.0 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ETS64473.1 - 8.7e-05 21.8 0.0 0.00099 18.3 0.0 2.0 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ETS64473.1 - 0.0027 16.9 0.0 4.3 6.3 0.0 3.3 1 1 2 3 3 3 2 Squalene-hopene cyclase N-terminal domain RRM_1 PF00076.22 ETS64474.1 - 0.00015 21.5 0.0 0.00028 20.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AlaDh_PNT_N PF05222.15 ETS64475.1 - 1.8e-27 96.3 0.0 2.9e-27 95.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 ETS64475.1 - 0.088 12.1 0.0 0.16 11.3 0.0 1.4 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Ribosomal_L32p PF01783.23 ETS64476.1 - 2.4e-14 53.3 5.9 3.3e-14 52.9 5.9 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 ETS64476.1 - 0.00033 20.0 1.1 0.00053 19.3 1.1 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zinc-ribbons_6 PF07191.12 ETS64476.1 - 0.012 15.6 0.8 0.017 15.1 0.8 1.2 1 0 0 1 1 1 0 zinc-ribbons Lung_7-TM_R PF06814.13 ETS64477.1 - 6.3e-50 170.1 14.7 1.7e-49 168.7 14.7 1.7 1 1 0 1 1 1 1 Lung seven transmembrane receptor Hum_adeno_E3A PF05393.11 ETS64477.1 - 0.14 12.2 0.2 0.4 10.7 0.2 1.7 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein PAP2 PF01569.21 ETS64478.1 - 2.5e-31 108.2 1.6 2.5e-31 108.2 1.6 2.0 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ETS64478.1 - 0.0029 17.3 8.8 0.0029 17.3 8.8 2.3 2 1 0 2 2 2 1 PAP2 superfamily Saf_2TM PF18303.1 ETS64478.1 - 0.028 14.0 0.1 0.053 13.1 0.1 1.4 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Colicin_V PF02674.16 ETS64478.1 - 0.034 14.1 2.3 5.8 6.9 0.0 2.6 2 0 0 2 2 2 0 Colicin V production protein Ytca PF17090.5 ETS64478.1 - 0.47 11.0 0.1 0.47 11.0 0.1 2.6 3 1 1 4 4 4 0 Uncharacterised protein family QRPTase_C PF01729.19 ETS64479.1 - 3.4e-50 170.1 0.6 5e-50 169.6 0.6 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain TP6A_N PF04406.14 ETS64479.1 - 8.1e-22 77.0 0.1 1.6e-21 76.1 0.1 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase QRPTase_N PF02749.16 ETS64479.1 - 1e-16 60.8 0.0 3.8e-16 58.9 0.0 2.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain DUF2399 PF09664.10 ETS64479.1 - 0.0046 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2399) KDGP_aldolase PF07071.11 ETS64479.1 - 0.018 14.8 0.1 0.036 13.9 0.1 1.5 1 0 0 1 1 1 0 KDGP aldolase Glyco_hydro_18 PF00704.28 ETS64480.1 - 1.1e-86 291.4 4.5 1.5e-86 291.0 4.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 PRCC PF10253.9 ETS64480.1 - 0.017 15.9 3.2 0.025 15.4 3.2 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting FAM101 PF15068.6 ETS64480.1 - 1.3 8.9 3.7 2.4 8.1 3.7 1.4 1 0 0 1 1 1 0 FAM101 family UTP15_C PF09384.10 ETS64481.1 - 1.7e-46 157.5 0.0 2.8e-46 156.8 0.0 1.4 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 ETS64481.1 - 1.7e-26 91.9 2.8 1.7e-07 31.8 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64481.1 - 1.5e-06 28.4 0.0 0.56 10.5 0.0 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS64481.1 - 0.0031 16.5 0.0 0.18 10.8 0.0 3.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ThuA PF06283.11 ETS64482.1 - 2.8e-56 191.1 2.1 3.5e-56 190.7 2.1 1.1 1 0 0 1 1 1 1 Trehalose utilisation Sfi1 PF08457.10 ETS64485.1 - 7.8e-27 94.0 143.8 1.1e-21 77.0 79.5 3.5 1 1 2 3 3 3 3 Sfi1 spindle body protein ABC_tran PF00005.27 ETS64486.1 - 4.4e-47 160.0 0.0 6.3e-26 91.5 0.0 3.5 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ETS64486.1 - 4.5e-15 56.2 0.4 0.026 14.3 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETS64486.1 - 7e-12 45.2 0.0 0.00049 19.6 0.0 3.4 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 ETS64486.1 - 2e-09 37.2 0.7 4.1e-09 36.2 0.7 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 ETS64486.1 - 1.5e-06 28.8 3.7 0.02 15.4 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 ETS64486.1 - 4e-06 26.5 0.5 0.063 13.0 0.2 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ETS64486.1 - 1.4e-05 25.2 0.8 0.014 15.4 0.0 3.4 3 1 0 3 3 2 1 50S ribosome-binding GTPase AAA_28 PF13521.6 ETS64486.1 - 5.5e-05 23.5 0.5 0.13 12.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ETS64486.1 - 0.00044 20.5 0.3 1.9 8.7 0.0 4.0 4 1 1 5 5 5 1 AAA domain DUF87 PF01935.17 ETS64486.1 - 0.00075 19.7 0.1 0.25 11.4 0.1 2.7 2 0 0 2 2 2 1 Helicase HerA, central domain RsgA_GTPase PF03193.16 ETS64486.1 - 0.0018 18.2 0.3 0.052 13.4 0.1 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 ETS64486.1 - 0.0026 17.5 0.4 1.9 8.2 0.0 3.7 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 ETS64486.1 - 0.0044 16.0 1.3 0.51 9.3 0.1 2.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 ETS64486.1 - 0.0044 17.4 0.9 2.1 8.7 0.0 3.9 3 1 1 4 4 4 1 AAA ATPase domain Tudor-knot PF11717.8 ETS64486.1 - 0.0055 16.6 0.6 0.012 15.4 0.6 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain AAA_18 PF13238.6 ETS64486.1 - 0.0063 17.1 0.1 2.3 8.8 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ETS64486.1 - 0.028 14.1 0.0 7.4 6.2 0.1 3.0 3 0 0 3 3 3 0 AAA domain CLASP_N PF12348.8 ETS64486.1 - 0.031 13.8 0.0 15 5.1 0.0 3.5 3 0 0 3 3 3 0 CLASP N terminal AAA_15 PF13175.6 ETS64486.1 - 0.1 12.3 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_27 PF13514.6 ETS64486.1 - 0.1 12.2 0.1 13 5.3 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ETS64486.1 - 0.11 12.6 0.0 8.2 6.6 0.0 2.8 2 0 0 2 2 2 0 AAA domain ALF PF03752.13 ETS64486.1 - 0.13 12.3 3.6 15 5.7 0.2 3.3 2 1 0 2 2 2 0 Short repeats of unknown function RNA_helicase PF00910.22 ETS64486.1 - 0.14 12.6 0.0 7.7 7.0 0.0 3.5 3 0 0 3 3 3 0 RNA helicase Dynamin_N PF00350.23 ETS64486.1 - 0.14 12.2 0.1 0.96 9.5 0.0 2.4 2 0 0 2 2 2 0 Dynamin family NACHT PF05729.12 ETS64486.1 - 0.16 11.9 0.1 21 5.0 0.0 2.6 2 0 0 2 2 2 0 NACHT domain HEAT_EZ PF13513.6 ETS64486.1 - 0.2 12.2 8.0 17 6.1 0.0 5.2 5 2 2 7 7 5 0 HEAT-like repeat cobW PF02492.19 ETS64486.1 - 0.21 11.1 1.3 14 5.2 0.0 3.3 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain DUF3720 PF12517.8 ETS64486.1 - 0.41 11.6 4.4 1.8 9.6 4.4 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3720) ABC_tran_Xtn PF12848.7 ETS64486.1 - 3.1 7.9 8.1 0.11 12.5 0.4 2.5 2 0 0 2 2 1 0 ABC transporter GATA PF00320.27 ETS64487.1 - 1.1e-17 63.4 1.9 2.1e-17 62.4 1.9 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 ETS64487.1 - 4.1e-13 48.9 1.3 8.6e-13 47.9 1.3 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TRAPPC9-Trs120 PF08626.11 ETS64488.1 - 4.7e-156 521.2 0.0 6.9e-156 520.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Herpes_ori_bp PF02399.15 ETS64488.1 - 0.21 9.6 0.0 0.3 9.1 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein DUF155 PF02582.14 ETS64489.1 - 1.4e-49 168.5 0.0 2.3e-49 167.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DHHC PF01529.20 ETS64490.1 - 3.2e-31 108.2 2.6 7.4e-31 107.0 2.6 1.6 1 0 0 1 1 1 1 DHHC palmitoyltransferase Ank_2 PF12796.7 ETS64490.1 - 6.7e-26 90.7 0.1 3.3e-13 50.0 0.0 3.2 2 2 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS64490.1 - 3.2e-19 69.0 3.4 2.9e-07 30.9 0.2 5.2 2 2 4 6 6 6 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETS64490.1 - 6e-19 67.9 2.5 2.5e-06 27.6 0.0 5.3 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 ETS64490.1 - 1.6e-16 59.9 4.6 0.00091 19.6 0.2 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 ETS64490.1 - 8.9e-16 56.4 2.6 0.00027 21.1 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeat HisKA_7TM PF16927.5 ETS64490.1 - 5.3 7.0 12.4 0.16 12.0 2.5 2.5 2 1 1 3 3 3 0 N-terminal 7TM region of histidine kinase Adaptin_N PF01602.20 ETS64491.1 - 3.9e-126 421.7 10.5 4.9e-126 421.4 10.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETS64491.1 - 1.5e-58 197.4 1.8 1.5e-58 197.4 1.8 3.0 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETS64491.1 - 1.6e-14 54.1 7.9 5.5e-07 29.9 0.4 4.7 2 2 4 6 6 6 4 HEAT repeats HEAT PF02985.22 ETS64491.1 - 1.3e-09 37.5 1.3 0.02 15.1 0.0 5.0 4 0 0 4 4 4 3 HEAT repeat Cnd3 PF12719.7 ETS64491.1 - 6.8e-06 25.5 0.2 0.021 14.0 0.0 2.5 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 ETS64491.1 - 9.6e-05 22.1 0.2 2.6 7.6 0.0 3.6 2 1 1 3 3 3 2 CLASP N terminal HEAT_EZ PF13513.6 ETS64491.1 - 0.00088 19.7 2.2 6 7.5 0.1 4.6 5 0 0 5 5 5 2 HEAT-like repeat Arm PF00514.23 ETS64491.1 - 0.0016 18.4 3.4 0.9 9.7 0.0 4.6 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Arm_2 PF04826.13 ETS64491.1 - 0.021 14.3 0.1 0.047 13.1 0.1 1.5 1 0 0 1 1 1 0 Armadillo-like RasGEF_N_2 PF14663.6 ETS64491.1 - 0.34 11.3 2.8 4 7.9 0.1 3.3 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Collagen PF01391.18 ETS64492.1 - 3.2 7.6 15.3 7.8e+02 -0.1 15.3 2.7 1 1 0 1 1 1 0 Collagen triple helix repeat (20 copies) COesterase PF00135.28 ETS64493.1 - 1.4e-92 311.2 0.0 2e-92 310.7 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS64493.1 - 2.5e-11 43.9 0.2 4.5e-11 43.0 0.2 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETS64493.1 - 0.0002 20.9 0.0 0.00039 20.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Spike_torovirin PF17072.5 ETS64493.1 - 0.04 11.1 0.0 0.055 10.6 0.0 1.1 1 0 0 1 1 1 0 Torovirinae spike glycoprotein MIF4G PF02854.19 ETS64495.1 - 0.00016 21.4 0.0 0.00027 20.6 0.0 1.3 1 0 0 1 1 1 1 MIF4G domain BORCS6 PF10157.9 ETS64495.1 - 0.066 13.4 0.1 0.21 11.8 0.1 1.9 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Ribosomal_S21 PF01165.20 ETS64496.1 - 8.6e-12 44.6 5.5 1.3e-11 44.0 5.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 RNA_capsid PF03035.14 ETS64496.1 - 0.048 13.7 1.5 0.21 11.6 0.4 1.9 2 0 0 2 2 2 0 Calicivirus putative RNA polymerase/capsid protein Fungal_trans PF04082.18 ETS64498.1 - 4.2e-21 75.2 0.0 7.1e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS64498.1 - 1.8e-09 37.6 1.5 3.5e-09 36.6 1.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Solute_trans_a PF03619.16 ETS64500.1 - 5.8e-89 298.1 13.2 7.1e-89 297.8 13.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha eIF-1a PF01176.19 ETS64501.1 - 9.4e-22 76.6 0.0 1.3e-21 76.1 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Cwf_Cwc_15 PF04889.12 ETS64501.1 - 0.056 13.2 6.6 0.059 13.1 6.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein YIF1 PF03878.15 ETS64502.1 - 1.7e-93 312.6 0.3 2e-93 312.3 0.3 1.1 1 0 0 1 1 1 1 YIF1 UCR_14kD PF02271.16 ETS64503.1 - 1e-39 134.5 1.7 1.2e-39 134.2 1.7 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Methyltransf_28 PF02636.17 ETS64504.1 - 2.6e-74 250.1 0.0 4.7e-74 249.3 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Amino_oxidase PF01593.24 ETS64504.1 - 2.4e-40 139.2 0.0 3.3e-40 138.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS64504.1 - 1.1e-11 44.7 0.0 2.7e-11 43.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETS64504.1 - 3e-08 33.7 0.1 7.8e-06 25.7 0.0 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS64504.1 - 8.6e-08 31.7 0.0 0.0081 15.4 0.0 3.2 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS64504.1 - 1.1e-05 24.4 0.0 0.01 14.6 0.0 2.3 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_9 PF13454.6 ETS64504.1 - 0.00064 19.7 0.4 0.17 11.9 0.0 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 ETS64504.1 - 0.012 14.9 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 ETS64504.1 - 0.017 14.0 0.0 0.029 13.2 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_2 PF00890.24 ETS64504.1 - 0.029 13.5 0.0 0.076 12.1 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain Fungal_trans PF04082.18 ETS64505.1 - 5.1e-07 29.0 3.4 3.2e-06 26.4 0.0 2.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS64505.1 - 0.0001 22.3 10.2 0.0001 22.3 10.2 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Mpp10 PF04006.12 ETS64505.1 - 3.1 6.1 28.6 0.091 11.2 16.6 2.3 2 0 0 2 2 2 0 Mpp10 protein CDC45 PF02724.14 ETS64505.1 - 3.3 5.9 30.7 0.033 12.5 19.0 2.3 2 0 0 2 2 2 0 CDC45-like protein Hist_deacetyl PF00850.19 ETS64506.1 - 6.1e-73 246.0 0.1 7.9e-73 245.6 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DEAD PF00270.29 ETS64507.1 - 2.3e-45 154.5 0.0 4.3e-45 153.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS64507.1 - 5.5e-23 81.4 0.0 3e-22 79.1 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ETS64507.1 - 6e-19 68.0 0.4 1.5e-18 66.7 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ETS64507.1 - 0.0028 17.7 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Utp21 PF04192.12 ETS64508.1 - 2.4e-51 174.5 0.0 2.4e-51 174.5 0.0 1.5 2 0 0 2 2 2 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 ETS64508.1 - 4.2e-10 40.1 8.3 0.24 12.3 0.0 7.7 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64508.1 - 6.7e-09 35.9 0.0 0.18 12.2 0.0 6.6 3 2 5 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ETS64508.1 - 0.00024 20.8 0.4 0.017 14.8 0.1 2.6 2 0 0 2 2 2 1 PQQ-like domain Cytochrom_D1 PF02239.16 ETS64508.1 - 0.017 13.7 0.6 0.16 10.5 0.3 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain RhlB PF12300.8 ETS64508.1 - 4.3 7.4 9.9 12 6.0 9.9 1.8 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Ribosomal_L27A PF00828.19 ETS64509.1 - 1.2e-34 119.8 0.0 1.6e-34 119.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A MerR_1 PF13411.6 ETS64509.1 - 0.098 12.8 0.0 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 MerR HTH family regulatory protein TIP49 PF06068.13 ETS64510.1 - 2.4e-167 556.5 1.6 8.5e-120 400.1 1.3 2.1 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 ETS64510.1 - 5.3e-24 84.1 1.1 3.1e-23 81.7 1.0 2.3 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 ETS64510.1 - 3.1e-08 34.1 4.6 3.5e-05 24.3 0.0 4.1 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETS64510.1 - 6.7e-07 29.2 0.4 0.0014 18.3 0.0 3.1 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 ETS64510.1 - 1.3e-06 28.0 0.8 1.3e-06 28.0 0.8 1.5 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 ETS64510.1 - 0.00047 19.6 2.2 0.011 15.2 0.3 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETS64510.1 - 0.0018 18.3 1.0 1.3 9.0 0.0 3.5 3 2 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 ETS64510.1 - 0.0019 18.6 1.6 0.012 15.9 0.3 2.7 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETS64510.1 - 0.0034 17.8 0.1 0.018 15.4 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 ETS64510.1 - 0.021 14.4 1.6 0.038 13.6 0.1 2.1 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETS64510.1 - 0.047 13.4 0.6 6.8 6.4 0.0 3.1 2 1 1 3 3 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 ETS64510.1 - 0.054 13.7 0.1 0.17 12.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETS64510.1 - 0.054 13.6 0.2 0.15 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETS64510.1 - 0.062 13.6 0.7 2.9 8.1 0.2 3.0 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 ETS64510.1 - 0.18 11.3 0.2 0.95 9.0 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_2 PF07724.14 ETS64510.1 - 1.4 9.0 5.6 1.1 9.4 0.1 3.1 2 2 1 3 3 3 0 AAA domain (Cdc48 subfamily) COG4 PF08318.12 ETS64511.1 - 1.3e-103 346.7 0.0 2.7e-103 345.6 0.0 1.5 1 1 0 1 1 1 1 COG4 transport protein HIP1_clath_bdg PF16515.5 ETS64511.1 - 0.022 15.4 3.2 0.079 13.6 3.2 2.0 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Sec7_N PF12783.7 ETS64511.1 - 0.033 14.1 0.4 0.12 12.3 0.1 2.0 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Spc7 PF08317.11 ETS64511.1 - 0.22 10.4 2.7 0.42 9.4 2.7 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Nuf2 PF03800.14 ETS64512.1 - 6.6e-37 126.7 0.0 6.6e-37 126.7 0.0 2.8 2 1 1 3 3 3 1 Nuf2 family DHR10 PF18595.1 ETS64512.1 - 0.00017 21.6 15.5 0.00017 21.6 15.5 4.0 2 2 2 4 4 4 1 Designed helical repeat protein 10 domain GM_CSF PF01109.17 ETS64512.1 - 0.0028 17.8 1.2 0.0028 17.8 1.2 2.9 2 1 1 3 3 3 1 Granulocyte-macrophage colony-stimulating factor Adhesin_P1_N PF18652.1 ETS64512.1 - 0.61 10.1 0.0 0.61 10.1 0.0 3.6 4 1 0 4 4 4 0 Adhesin P1 N-terminal domain ATP-synt_G PF04718.15 ETS64512.1 - 1.1 10.1 9.4 0.19 12.6 0.4 3.7 2 1 2 4 4 4 0 Mitochondrial ATP synthase g subunit THOC7 PF05615.13 ETS64512.1 - 1.4 9.2 44.3 0.061 13.6 8.5 3.7 2 1 2 4 4 4 0 Tho complex subunit 7 Baculo_PEP_C PF04513.12 ETS64512.1 - 1.6 8.8 19.3 0.73 9.9 3.1 3.9 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 ETS64512.1 - 4.2 7.4 32.0 3 7.9 6.9 4.1 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) Seryl_tRNA_N PF02403.22 ETS64512.1 - 6.2 7.1 43.9 0.78 10.0 11.6 4.4 1 1 3 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Spc7 PF08317.11 ETS64512.1 - 6.3 5.6 54.2 2.9 6.7 15.4 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein Phage_int_SAM_6 PF18644.1 ETS64512.1 - 6.8 6.7 11.6 0.41 10.7 0.7 3.4 1 1 1 3 3 3 0 Phage integrase SAM-like domain Methyltransf_16 PF10294.9 ETS64513.1 - 2e-18 66.7 0.0 5.4e-16 58.8 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ETS64513.1 - 4.5e-05 23.3 0.0 6.9e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS64513.1 - 0.012 16.3 0.0 0.037 14.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ETS64513.1 - 0.012 16.2 0.0 0.032 14.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ETS64513.1 - 0.049 13.0 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TehB PF03848.14 ETS64513.1 - 0.064 12.7 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB UPF0146 PF03686.13 ETS64513.1 - 0.14 12.0 0.0 0.97 9.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0146) FAM35_C PF15793.5 ETS64514.1 - 0.024 14.0 0.1 0.033 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein family FAM35, C-terminal VATC PF18716.1 ETS64515.1 - 0.042 13.7 0.2 0.07 13.0 0.2 1.3 1 0 0 1 1 1 0 Vms1-associating treble clef domain Glutaredoxin PF00462.24 ETS64516.1 - 1.4e-18 66.9 0.0 1e-17 64.1 0.0 2.2 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 ETS64516.1 - 1.4e-13 50.7 0.0 2.9e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ETS64516.1 - 0.0044 17.4 0.0 0.36 11.3 0.0 3.0 2 1 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 ETS64516.1 - 0.0068 16.4 0.2 0.069 13.2 0.1 2.5 2 1 0 2 2 2 1 Thioredoxin domain HyaE PF07449.11 ETS64516.1 - 0.009 16.0 0.0 0.12 12.3 0.0 2.4 2 1 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Thioredoxin_8 PF13905.6 ETS64516.1 - 0.01 16.2 0.0 0.32 11.4 0.0 2.6 2 1 0 3 3 3 0 Thioredoxin-like SH3BGR PF04908.15 ETS64516.1 - 0.041 14.0 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 SH3-binding, glutamic acid-rich protein Toxin-deaminase PF14424.6 ETS64516.1 - 0.17 12.0 0.1 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 The BURPS668_1122 family of deaminases RabGAP-TBC PF00566.18 ETS64517.1 - 8.3e-46 156.3 0.0 1.2e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Elongin_A PF06881.11 ETS64518.1 - 5.3e-32 110.5 0.4 8.3e-32 109.8 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A zinc_ribbon_15 PF17032.5 ETS64519.1 - 3.4e-06 27.7 0.6 3.4e-06 27.7 0.6 1.6 2 0 0 2 2 2 1 zinc-ribbon family zf-NADH-PPase PF09297.11 ETS64519.1 - 0.022 14.4 0.7 0.022 14.4 0.7 1.8 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ETS64519.1 - 0.25 11.4 5.7 1.3 9.1 5.7 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain RecR PF02132.15 ETS64519.1 - 0.31 10.6 2.3 13 5.5 0.2 2.2 2 0 0 2 2 2 0 RecR protein CM_2 PF01817.21 ETS64520.1 - 0.037 14.4 0.1 1 9.8 0.0 2.6 2 1 0 2 2 2 0 Chorismate mutase type II NIF PF03031.18 ETS64521.1 - 1.1e-21 77.2 0.0 1.6e-21 76.7 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase ubiquitin PF00240.23 ETS64521.1 - 0.00012 21.8 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family CO_deh_flav_C PF03450.17 ETS64521.1 - 0.15 12.3 0.0 0.47 10.7 0.0 1.8 2 0 0 2 2 2 0 CO dehydrogenase flavoprotein C-terminal domain SMN PF06003.12 ETS64521.1 - 0.27 10.5 1.5 0.73 9.0 0.7 1.9 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Kinesin PF00225.23 ETS64522.1 - 8.4e-113 376.7 0.0 8.4e-113 376.7 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETS64522.1 - 2.4e-28 99.0 0.0 1.1e-27 96.8 0.0 2.3 1 0 0 1 1 1 1 Microtubule binding DUF465 PF04325.13 ETS64522.1 - 6.1e-08 32.6 6.6 6.1e-08 32.6 6.6 4.0 3 1 0 3 3 3 1 Protein of unknown function (DUF465) ATG16 PF08614.11 ETS64522.1 - 3.6e-05 24.1 12.0 3.6e-05 24.1 12.0 5.6 2 2 2 5 5 5 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 ETS64522.1 - 0.0024 17.7 10.7 0.0024 17.7 10.7 6.1 4 3 2 6 6 6 2 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 ETS64522.1 - 0.012 15.7 17.1 0.012 15.7 17.1 6.4 2 1 2 6 6 6 0 TPR/MLP1/MLP2-like protein Sox_N PF12444.8 ETS64522.1 - 0.11 13.7 1.0 1.6 9.9 0.0 3.5 3 0 0 3 3 3 0 Sox developmental protein N terminal Filament PF00038.21 ETS64522.1 - 0.96 9.0 77.9 0.046 13.3 39.5 4.6 3 1 2 5 5 5 0 Intermediate filament protein YqeY PF09424.10 ETS64523.1 - 4.1e-14 52.9 1.7 4.1e-14 52.9 1.7 2.0 2 0 0 2 2 2 1 Yqey-like protein HBS1_N PF08938.10 ETS64523.1 - 7.9e-11 42.1 3.1 7.9e-11 42.1 3.1 2.0 2 0 0 2 2 2 1 HBS1 N-terminus DUF1296 PF06972.11 ETS64523.1 - 0.0026 17.9 0.1 0.0073 16.4 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1296) CM_2 PF01817.21 ETS64523.1 - 1.9 8.9 5.2 0.86 10.0 0.2 3.0 4 0 0 4 4 4 0 Chorismate mutase type II GTP_EFTU PF00009.27 ETS64524.1 - 1.6e-41 142.0 0.0 2.3e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETS64524.1 - 5.1e-12 46.1 0.0 1.1e-11 45.1 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETS64524.1 - 5.7e-07 29.8 0.5 1.7e-06 28.4 0.5 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETS64524.1 - 1e-06 28.8 0.0 2.3e-05 24.4 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 ETS64524.1 - 0.04 13.8 1.3 0.15 12.0 1.3 2.0 1 0 0 1 1 1 0 Elongation factor Tu domain 4 SRPRB PF09439.10 ETS64524.1 - 0.042 13.3 0.0 2.2 7.7 0.0 2.2 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 ETS64524.1 - 0.16 11.2 0.0 0.53 9.5 0.0 1.8 2 0 0 2 2 2 0 Septin HhH-GPD PF00730.25 ETS64525.1 - 3.5e-19 69.2 0.0 9.4e-19 67.9 0.0 1.7 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ETS64525.1 - 9.3e-09 34.7 0.0 4e-08 32.7 0.0 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ETS64525.1 - 0.077 13.6 0.0 0.22 12.1 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain OMPdecase PF00215.24 ETS64526.1 - 8.4e-75 251.2 0.0 1e-74 250.9 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Mit_ribos_Mrp51 PF11709.8 ETS64527.1 - 1e-11 45.1 1.8 4.2e-11 43.0 1.8 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein subunit Cyclin PF08613.11 ETS64528.1 - 2e-07 31.5 0.0 6.5e-07 29.9 0.0 1.9 1 0 0 1 1 1 1 Cyclin Gly-zipper_Omp PF13488.6 ETS64529.1 - 0.0049 16.8 1.5 0.0049 16.8 1.5 4.1 3 1 0 3 3 3 1 Glycine zipper Gly-zipper_YMGG PF13441.6 ETS64529.1 - 0.0077 16.0 0.2 0.0077 16.0 0.2 3.9 3 1 0 3 3 3 2 YMGG-like Gly-zipper TRM PF02005.16 ETS64530.1 - 6.7e-117 390.8 0.0 3.7e-89 299.5 0.0 2.0 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Amino_oxidase PF01593.24 ETS64531.1 - 1.5e-23 83.8 0.0 7.5e-23 81.5 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS64531.1 - 3.8e-12 46.3 0.3 1.4e-11 44.5 0.2 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETS64531.1 - 7.9e-11 41.7 0.3 3.3e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS64531.1 - 3.2e-09 36.8 1.9 4.2e-08 33.2 2.0 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETS64531.1 - 9.3e-06 25.0 1.2 0.00041 19.6 1.2 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ETS64531.1 - 2.6e-05 23.1 0.3 0.00061 18.6 0.4 2.2 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 ETS64531.1 - 0.00073 19.0 0.1 0.0021 17.5 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase MCRA PF06100.11 ETS64531.1 - 0.00082 18.3 0.1 0.15 10.8 0.0 2.1 2 0 0 2 2 2 2 MCRA family Pyr_redox PF00070.27 ETS64531.1 - 0.003 18.1 8.6 0.079 13.5 0.4 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 ETS64531.1 - 0.0035 17.0 0.8 0.0072 16.0 0.8 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA FAD_binding_3 PF01494.19 ETS64531.1 - 0.0048 16.2 1.3 0.0054 16.0 0.3 1.5 2 0 0 2 2 2 1 FAD binding domain NAD_Gly3P_dh_N PF01210.23 ETS64531.1 - 0.0061 16.6 0.1 0.012 15.7 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_9 PF13454.6 ETS64531.1 - 0.011 15.7 2.3 0.04 13.9 0.3 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_3 PF13738.6 ETS64531.1 - 0.02 14.2 0.4 0.035 13.4 0.4 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETS64531.1 - 0.024 13.5 3.5 0.98 8.2 0.2 2.2 2 0 0 2 2 2 0 Tryptophan halogenase Arteri_nsp7a PF16749.5 ETS64531.1 - 0.042 14.0 0.3 1.3 9.2 0.0 2.5 3 0 0 3 3 2 0 Arterivirus nonstructural protein 7 alpha TrkA_N PF02254.18 ETS64531.1 - 0.057 13.7 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain F420_oxidored PF03807.17 ETS64531.1 - 0.067 13.8 0.5 0.2 12.3 0.5 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 ETS64531.1 - 0.076 13.5 0.4 1.5 9.3 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding GMC_oxred_N PF00732.19 ETS64531.1 - 0.086 12.2 0.1 2.5 7.4 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Rossmann-like PF10727.9 ETS64531.1 - 0.086 12.7 0.4 0.17 11.7 0.4 1.4 1 0 0 1 1 1 0 Rossmann-like domain Thi4 PF01946.17 ETS64531.1 - 0.13 11.5 0.4 0.24 10.6 0.4 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 ETS64531.1 - 0.17 10.9 3.0 0.11 11.6 0.4 1.9 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 ETS64531.1 - 0.84 8.6 3.9 0.36 9.9 0.7 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Zn_clus PF00172.18 ETS64532.1 - 5.4e-07 29.6 11.2 1e-06 28.7 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ETS64532.1 - 3.4e-06 26.3 0.1 7.1e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain 4HBT PF03061.22 ETS64534.1 - 1.1e-09 38.6 0.0 1.8e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Ctf8 PF09696.10 ETS64535.1 - 0.04 14.3 0.1 0.084 13.2 0.1 1.5 1 0 0 1 1 1 0 Ctf8 Velvet PF11754.8 ETS64537.1 - 1.2e-34 120.4 0.0 1.2e-34 120.4 0.0 2.5 2 1 0 2 2 2 1 Velvet factor Velvet PF11754.8 ETS64538.1 - 6.2e-56 190.1 0.1 4.5e-38 131.6 0.0 3.4 2 2 1 3 3 3 2 Velvet factor UCH PF00443.29 ETS64541.1 - 1.2e-71 241.2 0.0 2.5e-71 240.2 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ETS64541.1 - 1.5e-17 64.0 0.0 3.4e-17 62.9 0.0 1.7 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 ETS64541.1 - 1.8e-11 44.2 0.0 3.1e-05 23.7 0.0 3.2 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ETS64541.1 - 0.0018 18.0 0.0 0.0033 17.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal ubiquitin PF00240.23 ETS64541.1 - 0.1 12.4 0.0 0.28 11.0 0.0 1.7 1 0 0 1 1 1 0 Ubiquitin family BCS1_N PF08740.11 ETS64542.1 - 7.4e-57 192.4 0.0 1.1e-56 191.8 0.0 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ETS64542.1 - 6.6e-17 62.2 0.0 1.1e-16 61.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ETS64542.1 - 0.0032 17.1 0.0 0.055 13.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ETS64542.1 - 0.0065 15.7 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 ETS64542.1 - 0.011 16.2 5.0 0.011 16.1 0.2 3.0 2 1 0 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 ETS64542.1 - 0.025 14.7 0.0 0.044 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETS64542.1 - 0.033 13.9 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 ETS64542.1 - 0.091 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase zn-ribbon_14 PF16503.5 ETS64543.1 - 6.1e-17 60.8 2.0 6.1e-17 60.8 2.0 3.4 3 0 0 3 3 3 1 Zinc-ribbon ATP_bind_3 PF01171.20 ETS64543.1 - 8.4e-16 58.2 0.0 1.5e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 PP-loop family CTU2 PF10288.9 ETS64543.1 - 0.0014 18.8 0.1 0.013 15.7 0.1 2.4 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 DUF4428 PF14471.6 ETS64543.1 - 0.089 12.7 1.8 0.93 9.5 0.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) DUF2616 PF11077.8 ETS64543.1 - 2.5 7.8 6.7 2.9 7.5 1.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) WD40 PF00400.32 ETS64544.1 - 1.8e-38 129.8 21.7 4.9e-06 27.2 0.1 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64544.1 - 4e-12 46.3 2.5 0.14 12.4 0.0 6.9 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS64544.1 - 0.00011 21.0 2.2 0.41 9.2 0.1 3.8 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETS64544.1 - 0.025 13.5 0.1 0.65 8.9 0.0 2.5 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RcnB PF11776.8 ETS64544.1 - 0.053 13.6 0.6 0.15 12.1 0.6 1.7 1 0 0 1 1 1 0 Nickel/cobalt transporter regulator OST3_OST6 PF04756.13 ETS64545.1 - 5.8e-89 298.3 2.8 9.5e-89 297.6 2.8 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 ETS64545.1 - 0.00012 22.0 0.1 0.0003 20.7 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin DUF1345 PF07077.11 ETS64545.1 - 0.027 14.2 0.3 0.47 10.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1345) DUF3112 PF11309.8 ETS64545.1 - 0.084 12.3 0.8 0.21 11.0 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3112) HlyIII PF03006.20 ETS64545.1 - 0.51 10.0 5.5 1.5 8.5 0.5 2.5 2 1 0 2 2 2 0 Haemolysin-III related DUF3784 PF12650.7 ETS64545.1 - 1.2 9.4 5.0 11 6.3 2.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3784) DUF2157 PF09925.9 ETS64545.1 - 2.2 8.0 8.6 1.9 8.2 1.0 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2157) VKOR PF07884.14 ETS64545.1 - 9.1 6.5 9.4 3.9 7.7 1.3 2.9 3 0 0 3 3 3 0 Vitamin K epoxide reductase family Dynamitin PF04912.14 ETS64546.1 - 2.4e-74 251.0 17.0 4.4e-74 250.2 17.0 1.4 1 1 0 1 1 1 1 Dynamitin Transp_cyt_pur PF02133.15 ETS64546.1 - 3.9e-30 105.0 26.5 6.9e-30 104.2 26.5 1.3 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Jnk-SapK_ap_N PF09744.9 ETS64546.1 - 0.00072 19.8 8.5 0.00078 19.7 3.1 2.6 2 1 0 2 2 2 1 JNK_SAPK-associated protein-1 Cob_adeno_trans PF01923.18 ETS64546.1 - 0.0012 19.0 2.6 0.074 13.2 0.3 2.5 2 0 0 2 2 2 1 Cobalamin adenosyltransferase Fib_alpha PF08702.10 ETS64546.1 - 0.0071 16.5 0.7 0.024 14.8 0.7 1.8 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Phage_Mu_F PF04233.14 ETS64546.1 - 0.0077 17.0 0.0 0.12 13.2 0.0 2.4 2 0 0 2 2 2 1 Phage Mu protein F like protein Snapin_Pallidin PF14712.6 ETS64546.1 - 0.0082 16.5 2.7 0.039 14.4 2.7 2.2 1 0 0 1 1 1 1 Snapin/Pallidin PhaP_Bmeg PF09602.10 ETS64546.1 - 0.049 13.6 0.3 0.13 12.2 0.3 1.6 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) SKA2 PF16740.5 ETS64546.1 - 0.077 12.8 5.0 0.08 12.7 2.1 2.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Tektin PF03148.14 ETS64546.1 - 0.17 10.6 4.7 0.41 9.3 4.7 1.5 1 0 0 1 1 1 0 Tektin family Matrilin_ccoil PF10393.9 ETS64546.1 - 0.21 11.5 6.6 0.2 11.6 0.4 3.4 3 0 0 3 3 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF3584 PF12128.8 ETS64546.1 - 0.41 8.1 12.2 0.033 11.7 5.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 ETS64546.1 - 0.48 9.3 6.5 1.1 8.0 2.1 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein Sugarporin_N PF11471.8 ETS64546.1 - 0.56 10.2 5.2 3.9 7.5 0.4 3.2 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension Mod_r PF07200.13 ETS64546.1 - 0.6 10.2 6.5 1.3 9.1 2.9 2.5 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF724 PF05266.14 ETS64546.1 - 1.4 8.7 4.1 2.6 7.8 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) DUF1690 PF07956.11 ETS64546.1 - 1.5 9.3 7.3 3.3 8.1 1.1 2.9 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) CENP-R PF06729.12 ETS64546.1 - 2.1 8.3 4.3 1.7 8.5 1.6 2.2 2 0 0 2 2 2 0 Kinetochore component, CENP-R DUF1664 PF07889.12 ETS64546.1 - 4.2 7.4 6.3 0.92 9.6 0.6 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) Dynactin_p22 PF07426.11 ETS64546.1 - 5 7.0 6.4 2.7 7.8 0.3 2.8 1 1 0 2 2 2 0 Dynactin subunit p22 Baculo_PEP_C PF04513.12 ETS64546.1 - 5.9 6.9 7.5 1.6 8.8 0.8 2.9 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus ZapB PF06005.12 ETS64546.1 - 9 6.8 15.2 4.6 7.8 2.1 3.8 2 2 1 3 3 3 0 Cell division protein ZapB ADK PF00406.22 ETS64547.1 - 5.8e-47 159.6 0.0 7.9e-47 159.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETS64547.1 - 1.1e-36 126.2 0.0 1.8e-36 125.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETS64547.1 - 7.5e-10 39.5 0.0 1.3e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETS64547.1 - 3.2e-05 24.1 0.0 0.00011 22.4 0.0 1.9 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ETS64547.1 - 0.00011 22.0 0.1 0.47 10.1 0.0 2.2 2 0 0 2 2 2 2 Thymidylate kinase Zeta_toxin PF06414.12 ETS64547.1 - 0.034 13.4 0.1 0.14 11.5 0.1 2.1 1 1 0 1 1 1 0 Zeta toxin DUF4202 PF13875.6 ETS64548.1 - 1.1e-64 217.8 0.2 2.3e-64 216.8 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) DUF1754 PF08555.10 ETS64548.1 - 3.3e-16 59.9 10.9 3.3e-16 59.9 10.9 2.6 3 0 0 3 3 3 1 Eukaryotic family of unknown function (DUF1754) Methyltransf_23 PF13489.6 ETS64548.1 - 2.1e-15 57.0 0.0 4.7e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS64548.1 - 3.1e-13 50.3 0.0 2.3e-12 47.5 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS64548.1 - 3.5e-13 50.1 0.0 1.4e-12 48.1 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS64548.1 - 1.5e-09 38.4 0.0 4.7e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS64548.1 - 6.6e-08 32.5 0.0 1.5e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 ETS64548.1 - 0.00012 23.1 0.0 0.00048 21.1 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS64548.1 - 0.001 18.7 0.1 0.0028 17.2 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain eRF1_2 PF03464.15 ETS64549.1 - 1e-45 155.3 0.0 2e-45 154.3 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ETS64549.1 - 2.8e-37 127.6 0.9 4.3e-37 127.0 0.1 1.8 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 ETS64549.1 - 3.4e-19 69.1 0.0 5.4e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 ETS64549.1 - 8.6e-08 32.5 0.0 1.7e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 ETS64549.1 - 5.2e-06 26.8 0.0 1.6e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 DUF3440 PF11922.8 ETS64549.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) DAZAP2 PF11029.8 ETS64549.1 - 0.049 14.5 3.7 0.096 13.6 3.7 1.4 1 0 0 1 1 1 0 DAZ associated protein 2 (DAZAP2) AAA PF00004.29 ETS64550.1 - 2.7e-56 189.6 0.0 3e-43 147.4 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 ETS64550.1 - 7.7e-25 87.1 0.1 1.8e-24 85.9 0.1 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 ETS64550.1 - 4.5e-16 58.4 0.3 1e-10 41.2 0.1 3.0 2 1 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ETS64550.1 - 7e-11 42.8 10.2 2.1e-05 25.0 0.9 4.9 3 2 1 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 ETS64550.1 - 1.5e-07 31.8 1.9 0.061 13.6 0.0 4.4 3 2 2 5 5 4 2 AAA domain AAA_25 PF13481.6 ETS64550.1 - 3.2e-07 30.1 4.2 0.062 12.9 0.0 4.2 2 2 1 4 4 4 3 AAA domain AAA_33 PF13671.6 ETS64550.1 - 1.9e-06 28.1 0.0 0.045 13.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 ETS64550.1 - 6.8e-06 26.7 0.0 0.13 12.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 ETS64550.1 - 1e-05 25.5 0.0 0.34 10.9 0.0 3.0 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 ETS64550.1 - 1.1e-05 25.3 0.0 0.0033 17.2 0.0 2.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 ETS64550.1 - 1.7e-05 24.3 0.3 0.18 11.2 0.0 3.2 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETS64550.1 - 2.1e-05 24.6 0.3 0.52 10.3 0.0 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 ETS64550.1 - 3.5e-05 23.2 0.0 0.011 15.0 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 ETS64550.1 - 3.5e-05 24.1 0.0 0.42 11.0 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.12 ETS64550.1 - 5.7e-05 22.5 0.1 0.077 12.3 0.0 2.7 3 0 0 3 3 3 2 Zeta toxin AAA_17 PF13207.6 ETS64550.1 - 5.8e-05 23.5 1.0 0.37 11.2 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_28 PF13521.6 ETS64550.1 - 0.00015 22.1 0.0 0.21 11.8 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 ETS64550.1 - 0.00015 21.8 0.0 0.68 10.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 ETS64550.1 - 0.00063 19.1 0.0 0.12 11.6 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 ETS64550.1 - 0.00063 19.9 0.0 0.086 13.0 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 ETS64550.1 - 0.00077 19.2 0.0 1.8 8.3 0.0 2.8 3 0 0 3 3 3 2 IstB-like ATP binding protein Viral_helicase1 PF01443.18 ETS64550.1 - 0.0015 18.3 0.0 0.32 10.7 0.0 2.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 ETS64550.1 - 0.0018 18.2 0.0 0.87 9.5 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain NACHT PF05729.12 ETS64550.1 - 0.0026 17.7 2.1 2.2 8.2 0.3 3.5 3 1 0 3 3 3 1 NACHT domain AAA_2 PF07724.14 ETS64550.1 - 0.004 17.3 0.0 0.051 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) SKI PF01202.22 ETS64550.1 - 0.0044 17.1 0.0 5 7.2 0.0 3.0 2 0 0 2 2 2 0 Shikimate kinase NB-ARC PF00931.22 ETS64550.1 - 0.0059 15.8 0.0 3.9 6.6 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain Cytidylate_kin2 PF13189.6 ETS64550.1 - 0.0085 16.2 0.1 0.92 9.6 0.0 2.8 2 0 0 2 2 2 1 Cytidylate kinase-like family APS_kinase PF01583.20 ETS64550.1 - 0.0086 16.0 2.1 0.32 10.9 0.0 3.6 3 1 1 4 4 4 1 Adenylylsulphate kinase AAA_3 PF07726.11 ETS64550.1 - 0.012 15.5 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETS64550.1 - 0.016 14.7 0.0 1.8 8.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 ETS64550.1 - 0.018 14.8 0.0 5.5 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ETS64550.1 - 0.022 14.1 0.0 6.3 6.1 0.0 2.4 2 0 0 2 2 2 0 KaiC ABC_tran PF00005.27 ETS64550.1 - 0.025 15.1 0.6 8.2 6.9 0.1 3.2 3 1 0 4 4 3 0 ABC transporter NTPase_1 PF03266.15 ETS64550.1 - 0.046 13.6 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 ETS64550.1 - 0.055 13.8 0.1 2 8.8 0.0 2.8 3 0 0 3 3 2 0 AAA domain KTI12 PF08433.10 ETS64550.1 - 0.069 12.6 0.1 0.72 9.2 0.0 2.5 2 1 0 2 2 2 0 Chromatin associated protein KTI12 Perilipin PF03036.16 ETS64551.1 - 2.8e-11 43.1 2.8 4.2e-08 32.6 0.1 2.2 1 1 1 2 2 2 2 Perilipin family FTA4 PF13093.6 ETS64551.1 - 0.051 13.5 0.1 0.074 12.9 0.1 1.3 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Gp-FAR-1 PF05823.12 ETS64551.1 - 0.092 13.1 0.8 0.16 12.3 0.8 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) LIF_OSM PF01291.17 ETS64551.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 LIF / OSM family p450 PF00067.22 ETS64552.1 - 7.1e-60 203.1 0.0 1.7e-52 178.8 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 HA2 PF04408.23 ETS64553.1 - 2e-21 76.3 0.0 2e-21 76.3 0.0 3.1 3 0 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETS64553.1 - 9.1e-15 54.8 0.0 2.8e-14 53.2 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ETS64553.1 - 2.7e-13 50.2 0.0 6e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETS64553.1 - 1.4e-08 34.7 0.0 3e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETS64553.1 - 5.5e-06 26.7 0.4 2.6e-05 24.5 0.4 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETS64553.1 - 0.00047 19.9 2.2 0.00058 19.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 ETS64553.1 - 0.0012 18.2 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ETS64553.1 - 0.002 18.5 0.1 0.0052 17.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETS64553.1 - 0.0029 17.8 0.5 0.059 13.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain T2SSE PF00437.20 ETS64553.1 - 0.0034 16.5 0.0 0.0081 15.2 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 ETS64553.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region SRP54 PF00448.22 ETS64553.1 - 0.021 14.4 0.2 0.055 13.1 0.2 1.7 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ABC_tran PF00005.27 ETS64553.1 - 0.025 15.1 0.3 0.079 13.5 0.0 2.1 2 0 0 2 2 1 0 ABC transporter ATPase PF06745.13 ETS64553.1 - 0.038 13.3 0.0 0.082 12.2 0.0 1.4 1 0 0 1 1 1 0 KaiC AAA_14 PF13173.6 ETS64553.1 - 0.045 13.8 0.1 0.33 11.0 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETS64553.1 - 0.097 13.0 0.7 0.46 10.9 0.0 2.7 2 0 0 2 2 1 0 AAA ATPase domain AAA_23 PF13476.6 ETS64553.1 - 0.097 13.2 0.1 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETS64553.1 - 0.16 11.7 0.0 0.81 9.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain cobW PF02492.19 ETS64553.1 - 0.19 11.3 0.1 1 9.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain HMA PF00403.26 ETS64554.1 - 1.8e-15 57.1 0.4 3.1e-15 56.4 0.4 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Melibiase_2 PF16499.5 ETS64557.1 - 2e-57 194.6 6.2 1.2e-56 191.9 6.2 2.0 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ETS64557.1 - 2.4e-09 37.1 0.5 9.4e-09 35.2 0.5 2.0 1 1 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ETS64557.1 - 4.7e-07 29.1 0.0 9.1e-07 28.1 0.0 1.4 1 0 0 1 1 1 1 Melibiase Raffinose_syn PF05691.12 ETS64557.1 - 5.2e-05 21.3 0.0 8.1e-05 20.6 0.0 1.2 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Melibiase_2_C PF17450.2 ETS64557.1 - 0.0014 18.8 0.0 0.0038 17.4 0.0 1.7 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain PX PF00787.24 ETS64558.1 - 3.4e-08 33.5 0.2 1.2e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 PX domain NDUF_B4 PF07225.12 ETS64559.1 - 0.00024 21.0 0.1 0.00028 20.8 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Integrase_Zn PF02022.19 ETS64559.1 - 0.022 14.7 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Integrase Zinc binding domain SNRNP27 PF08648.12 ETS64560.1 - 1.9e-29 101.5 0.5 1.9e-29 101.5 0.5 1.7 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins PDH PF02153.17 ETS64561.1 - 3.1e-17 62.5 0.0 7.3e-17 61.2 0.0 1.5 2 0 0 2 2 2 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 ETS64561.1 - 5.2e-05 23.5 0.0 0.00014 22.1 0.0 1.7 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ETS64561.1 - 6.6e-05 23.4 0.1 0.0003 21.3 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ETS64561.1 - 0.00079 19.5 0.0 0.0019 18.2 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ETS64561.1 - 0.0085 15.5 0.0 0.016 14.5 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 ETS64561.1 - 0.034 13.8 0.0 0.1 12.3 0.0 1.9 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA PI3_PI4_kinase PF00454.27 ETS64562.1 - 8.7e-54 183.0 0.0 1.5e-53 182.2 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 ETS64562.1 - 3.1e-38 131.3 0.2 1e-37 129.6 0.2 2.0 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 ETS64562.1 - 6.3e-09 35.5 0.1 1.7e-08 34.1 0.1 1.8 1 0 0 1 1 1 1 FATC domain FA_hydroxylase PF04116.13 ETS64563.1 - 3.7e-20 72.6 9.4 3.7e-20 72.6 9.4 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Mis12 PF05859.12 ETS64565.1 - 1e-26 93.6 0.0 1.9e-26 92.8 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein NDUFV3 PF15880.5 ETS64565.1 - 0.091 12.8 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Annexin PF00191.20 ETS64565.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Annexin Proteasome PF00227.26 ETS64566.1 - 5.9e-36 123.7 0.0 7.1e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit SAMP PF05924.11 ETS64566.1 - 0.02 14.2 0.7 0.032 13.5 0.7 1.3 1 0 0 1 1 1 0 SAMP Motif DUF2461 PF09365.10 ETS64567.1 - 2.9e-69 233.2 0.1 4.7e-69 232.5 0.1 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) IFT57 PF10498.9 ETS64567.1 - 0.15 11.0 1.9 0.24 10.3 1.9 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Presenilin PF01080.17 ETS64567.1 - 0.45 9.2 2.1 0.61 8.8 2.1 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETS64567.1 - 3.4 7.4 5.6 6.7 6.5 5.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Piwi PF02171.17 ETS64568.1 - 3.2e-78 263.0 0.0 4.7e-78 262.5 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 ETS64568.1 - 9.2e-12 45.8 0.0 1.8e-11 44.8 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 ETS64568.1 - 2.1e-11 43.3 0.0 5.4e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain PAZ PF02170.22 ETS64568.1 - 6.6e-11 42.2 0.0 1.3e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 ETS64568.1 - 8.1e-10 38.9 0.0 3.3e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoMid PF16487.5 ETS64568.1 - 1.9e-06 28.0 0.0 5.2e-06 26.6 0.0 1.8 1 1 0 1 1 1 1 Mid domain of argonaute tRNA_synthFbeta PF17759.1 ETS64569.1 - 7.4e-47 159.6 0.0 1.1e-46 159.0 0.0 1.2 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 ETS64569.1 - 1.4e-33 114.9 0.0 2.5e-32 110.9 0.0 2.4 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 ETS64569.1 - 3.2e-26 92.0 0.1 5.4e-26 91.3 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 ETS64569.1 - 5.4e-20 71.5 0.0 7.3e-18 64.6 0.0 2.7 2 0 0 2 2 2 1 tRNA synthetase B5 domain tRNA-synt_2d PF01409.20 ETS64569.1 - 0.069 12.6 0.0 13 5.2 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) WD40 PF00400.32 ETS64570.1 - 2e-09 37.9 7.0 0.068 14.1 0.0 6.5 6 0 0 6 6 6 3 WD domain, G-beta repeat CDC45 PF02724.14 ETS64570.1 - 0.0026 16.2 18.9 0.0026 16.2 18.9 3.0 3 0 0 3 3 3 1 CDC45-like protein LETM1 PF07766.13 ETS64571.1 - 7.9e-102 340.2 2.7 7.9e-102 340.2 2.7 2.4 2 0 0 2 2 2 1 LETM1-like protein EF-hand_7 PF13499.6 ETS64571.1 - 4.8e-07 30.1 6.3 7.8e-07 29.5 0.2 3.7 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_8 PF13833.6 ETS64571.1 - 6.2e-05 22.8 0.2 0.00021 21.1 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair DUF1682 PF07946.14 ETS64571.1 - 0.0012 18.1 11.5 0.0025 17.1 11.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) EF-hand_1 PF00036.32 ETS64571.1 - 0.0017 17.7 0.8 1 9.0 0.0 3.7 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ETS64571.1 - 0.0017 18.1 0.2 4.8 7.4 0.0 3.3 3 0 0 3 3 3 2 EF-hand domain RPA_C PF08784.11 ETS64571.1 - 0.019 15.6 0.5 0.086 13.5 0.5 2.1 1 0 0 1 1 1 0 Replication protein A C terminal TIR_2 PF13676.6 ETS64571.1 - 0.045 14.4 0.0 0.25 12.0 0.0 2.3 2 0 0 2 2 2 0 TIR domain Iron_traffic PF04362.14 ETS64571.1 - 0.67 9.7 2.6 1.4 8.7 0.1 2.4 2 0 0 2 2 2 0 Bacterial Fe(2+) trafficking TatD_DNase PF01026.21 ETS64572.1 - 4.1e-52 177.1 0.3 5.3e-52 176.7 0.3 1.1 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ETS64572.1 - 0.011 15.5 0.3 0.73 9.6 0.0 2.7 3 0 0 3 3 3 0 Amidohydrolase Rot1 PF10681.9 ETS64573.1 - 6.4e-58 195.7 1.5 9e-58 195.2 1.5 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal p31comet PF06581.12 ETS64574.1 - 0.0022 17.2 0.6 0.29 10.3 0.1 3.2 3 0 0 3 3 3 2 Mad1 and Cdc20-bound-Mad2 binding Coatomer_WDAD PF04053.14 ETS64575.1 - 3.9e-137 458.0 0.0 6.2e-137 457.3 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 ETS64575.1 - 7.5e-98 327.9 0.0 1.2e-97 327.3 0.0 1.3 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 ETS64575.1 - 1.3e-41 139.8 12.9 7.6e-08 32.9 0.4 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64575.1 - 4.3e-12 46.2 0.1 0.0047 17.2 0.0 5.8 4 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1712 PF08217.11 ETS64575.1 - 1.3e-08 33.8 0.0 2.3e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Clathrin PF00637.20 ETS64575.1 - 0.054 13.4 0.1 0.23 11.3 0.0 2.1 2 0 0 2 2 2 0 Region in Clathrin and VPS Nup160 PF11715.8 ETS64575.1 - 0.51 8.9 3.9 3.6 6.1 0.0 3.1 1 1 2 3 3 3 0 Nucleoporin Nup120/160 GDC-P PF02347.16 ETS64576.1 - 5.2e-181 602.2 0.0 9.9e-169 561.7 0.0 2.8 3 0 0 3 3 3 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 ETS64576.1 - 2e-06 27.3 0.1 3.7e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ETS64576.1 - 4.5e-05 22.6 0.1 9.4e-05 21.5 0.1 1.5 1 0 0 1 1 1 1 Aminotransferase class-V ATP-synt_D PF01813.17 ETS64577.1 - 3.8e-73 245.5 1.9 4.9e-73 245.2 1.9 1.1 1 0 0 1 1 1 1 ATP synthase subunit D XRN_M PF17846.1 ETS64577.1 - 0.68 8.8 6.9 1.2 8.0 6.9 1.3 1 0 0 1 1 1 0 Xrn1 helical domain DUF913 PF06025.12 ETS64577.1 - 0.84 8.5 4.0 1.3 7.9 4.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 ETS64577.1 - 5.2 5.5 7.0 7.6 4.9 7.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETS64577.1 - 9.7 4.3 17.6 16 3.6 17.6 1.3 1 0 0 1 1 1 0 CDC45-like protein She9_MDM33 PF05546.11 ETS64578.1 - 4.5e-66 222.4 7.7 6.9e-66 221.8 7.7 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family HupE_UreJ_2 PF13795.6 ETS64578.1 - 0.033 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 HupE / UreJ protein DUF2371 PF10177.9 ETS64578.1 - 0.2 11.8 0.0 0.46 10.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Cep57_CLD PF14073.6 ETS64578.1 - 0.42 10.6 12.5 0.83 9.7 8.6 2.2 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Rep_fac-A_3 PF08661.11 ETS64579.1 - 2.1e-30 105.1 0.1 2.4e-30 105.0 0.1 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 DUF1365 PF07103.11 ETS64580.1 - 4.5e-63 213.1 0.0 8.4e-63 212.2 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1365) SET PF00856.28 ETS64581.1 - 6.6e-09 36.4 0.0 2.5e-08 34.5 0.0 2.0 1 1 0 1 1 1 1 SET domain Mito_carr PF00153.27 ETS64582.1 - 3.6e-56 187.1 6.5 2.4e-23 81.9 0.0 3.7 3 1 0 3 3 3 3 Mitochondrial carrier protein Sec10 PF07393.11 ETS64583.1 - 2e-82 277.8 0.0 6.2e-82 276.1 0.0 1.8 1 1 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 ETS64583.1 - 3.7e-05 23.5 0.2 0.0001 22.1 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETS64583.1 - 0.0055 16.5 0.1 0.014 15.2 0.1 1.7 1 0 0 1 1 1 1 F-box domain DUF5102 PF17104.5 ETS64583.1 - 0.045 13.8 0.9 0.11 12.6 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) Spo7 PF03907.13 ETS64584.1 - 8.6e-44 149.6 1.1 8.6e-44 149.6 1.1 1.7 1 1 1 2 2 2 1 Spo7-like protein Tmemb_18A PF09771.9 ETS64584.1 - 7.4e-05 23.1 3.8 0.00019 21.8 0.6 2.1 2 0 0 2 2 2 1 Transmembrane protein 188 CCDC24 PF15669.5 ETS64584.1 - 0.0059 16.5 3.5 2 8.2 4.1 2.2 1 1 0 2 2 2 2 Coiled-coil domain-containing protein 24 family NEMP PF10225.9 ETS64584.1 - 0.0079 15.9 0.5 0.012 15.3 0.5 1.2 1 0 0 1 1 1 1 NEMP family Rib_5-P_isom_A PF06026.14 ETS64585.1 - 8.9e-60 201.2 0.0 1.3e-59 200.7 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 ETS64585.1 - 0.014 15.4 0.0 0.9 9.5 0.0 2.3 2 0 0 2 2 2 0 DeoR C terminal sensor domain NUC173 PF08161.12 ETS64586.1 - 6.5e-62 208.8 0.3 1.4e-60 204.5 0.1 2.9 3 0 0 3 3 3 1 NUC173 domain MMS19_C PF12460.8 ETS64586.1 - 1e-05 24.9 9.0 0.01 15.0 0.2 3.1 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal DUF1018 PF06252.12 ETS64586.1 - 0.12 13.4 1.1 6.3 7.8 0.0 4.1 5 0 0 5 5 5 0 Protein of unknown function (DUF1018) dsDNA_bind PF01984.20 ETS64586.1 - 2.3 8.5 7.3 0.86 9.9 1.4 3.1 2 0 0 2 2 2 0 Double-stranded DNA-binding domain THOC2_N PF16134.5 ETS64586.1 - 2.7 6.5 6.9 0.74 8.4 3.4 1.8 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus DUF4604 PF15377.6 ETS64587.1 - 6.1e-23 82.1 17.5 8e-23 81.7 17.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) EHN PF06441.12 ETS64588.1 - 2.2e-24 85.9 0.7 8.3e-24 84.0 0.0 2.4 3 0 0 3 3 3 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ETS64588.1 - 7e-15 55.4 0.3 2.5e-14 53.5 0.5 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold CENP-I PF07778.11 ETS64589.1 - 0.15 10.8 0.0 0.2 10.4 0.0 1.1 1 0 0 1 1 1 0 Mis6 DEAD_2 PF06733.15 ETS64590.1 - 4e-51 173.1 0.0 4.4e-45 153.4 0.0 2.6 3 0 0 3 3 3 2 DEAD_2 HBB PF06777.11 ETS64590.1 - 1.2e-46 158.8 1.1 3.4e-43 147.5 0.2 2.5 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 ETS64590.1 - 3.6e-44 150.9 0.0 7.8e-44 149.9 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 ETS64590.1 - 0.00014 21.9 0.0 0.012 15.7 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETS64590.1 - 0.0029 17.4 0.4 1.1 9.0 0.0 2.9 4 0 0 4 4 4 2 DEAD/DEAH box helicase ABC_tran PF00005.27 ETS64591.1 - 4.7e-44 150.2 0.1 1.3e-21 77.5 0.0 4.2 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ETS64591.1 - 3.2e-16 60.0 0.2 0.0081 16.0 0.0 4.3 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETS64591.1 - 8e-12 45.1 2.2 0.23 10.9 0.0 4.3 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ETS64591.1 - 4.2e-09 36.0 0.7 0.0026 17.5 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain HEAT_2 PF13646.6 ETS64591.1 - 3.8e-08 33.6 1.1 0.0017 18.7 0.1 4.4 3 1 1 4 4 4 2 HEAT repeats CLASP_N PF12348.8 ETS64591.1 - 9.3e-06 25.4 0.0 4.6e-05 23.1 0.0 2.0 1 1 0 1 1 1 1 CLASP N terminal AAA_22 PF13401.6 ETS64591.1 - 2.3e-05 24.7 0.1 0.22 11.8 0.0 3.6 4 0 0 4 4 3 1 AAA domain Chromo PF00385.24 ETS64591.1 - 2.8e-05 23.9 0.1 6.6e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 ETS64591.1 - 6e-05 23.6 12.6 0.0071 16.9 0.0 3.8 3 1 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 ETS64591.1 - 6.9e-05 22.9 0.0 0.15 12.2 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 ETS64591.1 - 8.9e-05 23.0 0.1 0.059 13.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETS64591.1 - 0.00028 21.3 0.1 3.7 8.0 0.0 4.7 5 1 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) HEAT PF02985.22 ETS64591.1 - 0.00034 20.6 4.1 0.048 13.9 0.0 4.8 6 0 0 6 6 3 1 HEAT repeat AAA_30 PF13604.6 ETS64591.1 - 0.00042 20.1 0.5 11 5.7 0.1 3.8 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 ETS64591.1 - 0.00052 20.3 0.0 1.7 8.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 ETS64591.1 - 0.00075 19.4 0.2 0.99 9.3 0.0 2.8 3 0 0 3 3 2 1 NACHT domain HEAT_EZ PF13513.6 ETS64591.1 - 0.00079 19.9 1.1 0.031 14.8 0.1 4.1 3 1 1 4 4 3 1 HEAT-like repeat RsgA_GTPase PF03193.16 ETS64591.1 - 0.0012 18.8 0.1 1.7 8.5 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase DUF87 PF01935.17 ETS64591.1 - 0.0015 18.7 4.8 0.21 11.7 0.1 3.8 4 0 0 4 4 3 1 Helicase HerA, central domain AAA_16 PF13191.6 ETS64591.1 - 0.0016 18.8 0.2 0.99 9.8 0.0 3.7 3 1 1 4 4 3 1 AAA ATPase domain 4HB PF17947.1 ETS64591.1 - 0.0017 18.4 0.0 0.0057 16.7 0.0 1.9 1 0 0 1 1 1 1 Four helical bundle domain G-alpha PF00503.20 ETS64591.1 - 0.0018 17.5 0.0 0.39 9.8 0.0 2.5 2 0 0 2 2 2 1 G-protein alpha subunit NB-ARC PF00931.22 ETS64591.1 - 0.0021 17.3 0.0 1 8.5 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 ETS64591.1 - 0.0023 18.1 0.0 3 8.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 ETS64591.1 - 0.0031 17.3 7.0 0.28 10.8 0.0 3.2 2 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ETS64591.1 - 0.0039 17.5 0.0 4.9 7.6 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_24 PF13479.6 ETS64591.1 - 0.0057 16.4 0.0 0.61 9.8 0.0 2.8 2 0 0 2 2 2 1 AAA domain Cnd1 PF12717.7 ETS64591.1 - 0.0066 16.5 0.2 0.38 10.8 0.2 2.6 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 AAA_5 PF07728.14 ETS64591.1 - 0.014 15.4 5.4 23 5.0 0.1 5.2 5 0 0 5 5 5 0 AAA domain (dynein-related subfamily) MeaB PF03308.16 ETS64591.1 - 0.014 14.4 1.7 0.55 9.2 0.1 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB UME PF08064.13 ETS64591.1 - 0.016 15.1 1.9 2 8.4 0.6 3.1 2 1 1 3 3 3 0 UME (NUC010) domain SbcCD_C PF13558.6 ETS64591.1 - 0.019 15.2 0.2 0.91 9.8 0.0 3.3 3 2 0 3 3 2 0 Putative exonuclease SbcCD, C subunit DRIM PF07539.12 ETS64591.1 - 0.02 13.2 1.1 0.61 8.3 0.1 2.1 1 1 0 2 2 2 0 Down-regulated in metastasis Roc PF08477.13 ETS64591.1 - 0.034 14.4 0.0 13 6.0 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 ETS64591.1 - 0.043 13.7 0.1 5.7 6.8 0.0 2.6 2 0 0 2 2 2 0 NTPase Mg_chelatase PF01078.21 ETS64591.1 - 0.048 13.0 0.9 22 4.4 0.0 3.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ETS64591.1 - 0.062 12.5 1.3 8 5.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 ETS64591.1 - 0.084 12.2 0.4 11 5.2 0.1 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Vac14_Fab1_bd PF12755.7 ETS64591.1 - 0.12 13.0 0.0 6.7 7.4 0.0 2.8 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region AAA_7 PF12775.7 ETS64591.1 - 0.12 11.8 0.2 14 5.1 0.1 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF3584 PF12128.8 ETS64591.1 - 0.22 9.0 8.6 0.41 8.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3584) ATP_bind_1 PF03029.17 ETS64591.1 - 0.23 11.2 1.8 9.3 5.9 0.0 2.8 3 0 0 3 3 2 0 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ETS64591.1 - 0.38 10.5 1.9 17 5.2 0.0 3.3 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop cobW PF02492.19 ETS64591.1 - 1.4 8.5 4.1 20 4.7 0.1 2.8 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_13 PF13166.6 ETS64591.1 - 1.5 7.4 7.0 2.9 6.4 0.0 3.1 4 0 0 4 4 3 0 AAA domain ATPase_2 PF01637.18 ETS64591.1 - 8 6.3 11.5 10 5.9 0.0 3.9 5 0 0 5 5 4 0 ATPase domain predominantly from Archaea Dopey_N PF04118.14 ETS64592.1 - 1.2e-107 359.6 0.0 2.3e-107 358.7 0.0 1.5 1 0 0 1 1 1 1 Dopey, N-terminal Erythro-docking PF09277.11 ETS64592.1 - 0.56 10.1 5.8 0.18 11.7 1.1 2.7 2 0 0 2 2 2 0 Erythronolide synthase, docking RRM_1 PF00076.22 ETS64593.1 - 2.1e-16 59.5 0.0 3.2e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS64593.1 - 0.00011 21.8 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETS64593.1 - 0.087 13.0 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif RL PF17797.1 ETS64593.1 - 0.12 12.4 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 RL domain Sporozoite_P67 PF05642.11 ETS64593.1 - 0.48 8.4 4.0 0.67 8.0 4.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4726 PF15855.5 ETS64593.1 - 1.8 8.8 7.0 0.16 12.2 2.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4726) Ribosomal_S15 PF00312.22 ETS64594.1 - 3.5e-25 88.0 0.4 6.7e-25 87.1 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S15 bPH_6 PF10756.9 ETS64594.1 - 0.017 15.2 0.1 0.055 13.6 0.1 1.9 1 0 0 1 1 1 0 Bacterial PH domain RNA_pol_Rpb1_7 PF04990.12 ETS64594.1 - 0.15 12.0 0.1 1.5 8.8 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 7 Exo84_C PF16528.5 ETS64595.1 - 3.7e-49 167.3 1.0 6.7e-49 166.5 1.0 1.4 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 ETS64595.1 - 1.8e-18 66.4 0.4 5.7e-18 64.8 0.4 1.9 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ETS64595.1 - 0.00061 19.9 1.6 0.0011 19.0 0.2 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 TetR_C_33 PF13305.6 ETS64595.1 - 0.2 12.4 0.0 0.2 12.4 0.0 3.4 4 1 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain EXS PF03124.14 ETS64596.1 - 2.5e-79 267.0 23.0 3.9e-79 266.4 23.0 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ETS64596.1 - 5.2e-55 187.9 2.8 5.2e-55 187.9 2.8 2.1 2 0 0 2 2 2 1 SPX domain ParE_toxin PF05016.15 ETS64596.1 - 0.071 13.7 0.8 0.79 10.4 0.4 2.8 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE HECT_2 PF09814.9 ETS64597.1 - 9e-28 97.2 0.0 1.7e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding hNIFK_binding PF12196.8 ETS64597.1 - 0.037 13.5 0.0 0.1 12.1 0.0 1.7 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK FH2 PF02181.23 ETS64598.1 - 6.1e-65 219.7 14.4 9.7e-65 219.1 6.5 2.3 2 0 0 2 2 2 2 Formin Homology 2 Domain Drf_FH3 PF06367.16 ETS64598.1 - 4.9e-44 150.3 0.0 5.1e-43 147.0 0.0 2.4 1 1 1 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ETS64598.1 - 1e-43 149.1 0.1 8.8e-43 146.1 0.0 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain CorA PF01544.18 ETS64598.1 - 0.11 11.7 12.5 0.34 10.2 0.5 2.5 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein CorA PF01544.18 ETS64599.1 - 1.6e-11 44.1 0.6 2.2e-11 43.7 0.6 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein UreD PF01774.17 ETS64600.1 - 4.4e-67 226.1 0.4 7.8e-67 225.3 0.4 1.4 1 0 0 1 1 1 1 UreD urease accessory protein EI24 PF07264.11 ETS64600.1 - 1.1e-05 25.8 5.6 2.2e-05 24.8 5.6 1.6 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) TAL_FSA PF00923.19 ETS64601.1 - 8.3e-95 317.4 0.4 9.4e-95 317.2 0.4 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Pro_isomerase PF00160.21 ETS64602.1 - 5.5e-49 166.5 0.0 6.3e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Pkinase PF00069.25 ETS64603.1 - 8.5e-58 195.8 0.0 1.1e-57 195.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64603.1 - 1.5e-28 99.8 0.0 2.1e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS64603.1 - 0.0007 19.0 0.0 0.0014 18.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETS64603.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ETS64603.1 - 0.019 14.6 0.0 0.74 9.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ETS64603.1 - 0.02 14.8 0.3 1.2 9.0 0.2 2.4 1 1 1 2 2 2 0 Phosphotransferase enzyme family adh_short PF00106.25 ETS64604.1 - 1.2e-38 132.6 0.1 1.9e-38 131.9 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS64604.1 - 3.3e-37 128.3 0.9 2.1e-36 125.7 0.9 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS64604.1 - 1.6e-07 31.5 0.5 1.6e-07 31.5 0.5 2.2 2 0 0 2 2 2 1 KR domain Baculo_p47 PF05112.12 ETS64604.1 - 0.073 12.7 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Baculovirus P47 protein Ribonuc_L-PSP PF01042.21 ETS64604.1 - 0.097 12.7 0.1 9.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Endoribonuclease L-PSP Meth_synt_2 PF01717.18 ETS64605.1 - 1.1e-17 64.3 0.0 1.7e-17 63.7 0.0 1.3 1 0 0 1 1 1 1 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ETS64605.1 - 0.0091 15.5 0.1 0.25 10.8 0.0 2.7 3 0 0 3 3 3 1 Cobalamin-independent synthase, N-terminal domain BIR PF00653.21 ETS64606.1 - 9.1e-30 103.1 0.3 3.6e-23 82.0 0.6 2.4 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain SHQ1 PF04925.15 ETS64607.1 - 3e-27 95.3 0.0 4.9e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 SHQ1 protein WAPL PF07814.13 ETS64607.1 - 1.4e-08 33.9 0.0 2.1e-07 30.1 0.0 2.6 3 1 0 3 3 3 1 Wings apart-like protein regulation of heterochromatin Glyco_hydro_46 PF01374.18 ETS64607.1 - 0.091 12.4 0.5 0.18 11.4 0.5 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 46 SNF2_N PF00176.23 ETS64608.1 - 6e-26 91.0 0.0 3e-15 55.8 0.0 2.2 2 0 0 2 2 2 2 SNF2 family N-terminal domain DNA_methylase PF00145.17 ETS64608.1 - 1.7e-11 44.1 0.0 3.6e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 C-5 cytosine-specific DNA methylase Helicase_C PF00271.31 ETS64608.1 - 0.00023 21.5 0.0 0.00054 20.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS64608.1 - 0.029 14.4 0.0 0.21 11.5 0.0 2.2 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Fer2 PF00111.27 ETS64608.1 - 1 9.4 8.2 30 4.7 3.7 3.7 3 0 0 3 3 3 0 2Fe-2S iron-sulfur cluster binding domain zf-C3HC4_2 PF13923.6 ETS64608.1 - 4.1 7.3 8.9 3.2 7.7 0.5 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS64608.1 - 7.8 6.6 9.3 2.7 8.1 0.5 2.7 2 0 0 2 2 2 0 RING-type zinc-finger SURF2 PF05477.11 ETS64608.1 - 9 5.9 8.7 39 3.8 8.7 2.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SNF2_N PF00176.23 ETS64610.1 - 5.9e-62 209.4 0.2 3.4e-61 206.9 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS64610.1 - 1.7e-21 76.7 0.2 5.2e-21 75.1 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ETS64610.1 - 1.2e-10 41.1 1.0 3.6e-08 32.9 0.0 3.2 3 0 0 3 3 3 2 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ETS64610.1 - 1.8e-10 41.1 0.0 3e-08 33.8 0.0 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ETS64610.1 - 0.014 15.7 1.2 2.5 8.4 0.1 3.4 3 0 0 3 3 3 0 AAA domain AT_hook PF02178.19 ETS64610.1 - 0.038 13.8 5.1 0.15 12.0 5.1 2.1 1 0 0 1 1 1 0 AT hook motif HAND PF09110.11 ETS64610.1 - 0.5 11.1 0.1 0.5 11.1 0.1 3.9 3 1 0 3 3 3 0 HAND COG4 PF08318.12 ETS64610.1 - 9.5 5.2 10.7 0.035 13.2 0.7 1.9 2 0 0 2 2 2 0 COG4 transport protein Aminotran_5 PF00266.19 ETS64611.1 - 1.2e-17 63.9 0.1 2.7e-17 62.8 0.1 1.7 1 1 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ETS64611.1 - 8.6e-05 21.2 0.1 0.00021 20.0 0.0 1.6 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ETS64611.1 - 0.0037 16.5 0.0 0.0059 15.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II 3Beta_HSD PF01073.19 ETS64612.1 - 5.3e-58 196.2 0.0 1.8e-52 178.1 0.0 2.3 2 1 0 2 2 2 2 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETS64612.1 - 5.8e-23 81.6 0.1 9e-23 81.0 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS64612.1 - 1.5e-11 44.3 0.0 4.3e-08 32.9 0.1 2.6 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ETS64612.1 - 2.5e-08 33.4 0.2 1.4e-07 30.9 0.2 2.0 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 ETS64612.1 - 1.3e-06 27.8 0.0 1.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ETS64612.1 - 4.7e-05 23.4 0.3 8.4e-05 22.5 0.3 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ETS64612.1 - 0.00066 18.9 0.1 0.0014 17.9 0.0 1.4 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein TrkA_N PF02254.18 ETS64612.1 - 0.0046 17.2 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.10 ETS64612.1 - 0.023 14.6 0.3 0.089 12.7 0.3 1.9 1 1 0 1 1 1 0 KR domain ELFV_dehydrog PF00208.21 ETS64612.1 - 0.048 13.4 0.0 0.089 12.5 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_rhodopsin PF01036.18 ETS64613.1 - 3.1e-34 118.5 15.3 4.8e-24 85.2 6.9 2.1 1 1 0 2 2 2 2 Bacteriorhodopsin-like protein TMEM189_B_dmain PF10520.9 ETS64613.1 - 0.091 12.9 0.4 0.2 11.7 0.4 1.5 1 0 0 1 1 1 0 B domain of TMEM189, localisation domain DUF1304 PF06993.12 ETS64613.1 - 0.34 10.9 6.4 0.47 10.5 2.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1304) EamA PF00892.20 ETS64614.1 - 5e-21 75.3 30.3 3.6e-11 43.4 5.8 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 ETS64614.1 - 0.57 9.5 7.2 0.8 9.0 0.2 2.4 2 1 0 2 2 2 0 Triose-phosphate Transporter family Trp_oprn_chp PF09534.10 ETS64614.1 - 0.69 9.7 10.1 1.3 8.8 0.4 2.6 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RseC_MucC PF04246.12 ETS64614.1 - 1.7 8.6 10.2 17 5.4 0.4 3.4 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC Inv-AAD PF18785.1 ETS64615.1 - 3e-28 98.3 0.0 1e-23 83.6 0.0 2.2 2 0 0 2 2 2 2 Invertebrate-AID/APOBEC-deaminase PAP2 PF01569.21 ETS64615.1 - 9.2e-12 44.9 5.7 7.5e-11 41.9 5.7 2.1 1 1 0 1 1 1 1 PAP2 superfamily dCMP_cyt_deam_1 PF00383.23 ETS64615.1 - 5.8e-11 42.2 0.0 1.1e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region SNAD4 PF18750.1 ETS64615.1 - 0.0087 16.2 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 UbiA PF01040.18 ETS64615.1 - 0.0093 15.3 1.0 0.0093 15.3 1.0 1.8 2 1 0 2 2 2 1 UbiA prenyltransferase family APOBEC_N PF08210.11 ETS64615.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain DUF212 PF02681.14 ETS64615.1 - 0.078 13.1 0.1 8 6.6 0.0 2.5 2 0 0 2 2 2 0 Divergent PAP2 family OTU PF02338.19 ETS64616.1 - 1.1e-22 80.9 0.0 1.8e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ETS64616.1 - 0.019 14.4 0.0 1.1 8.6 0.0 2.5 1 1 0 2 2 2 0 Peptidase C65 Otubain T2SSM PF04612.12 ETS64616.1 - 0.035 14.2 1.1 0.083 12.9 1.1 1.6 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Band_3_cyto PF07565.13 ETS64616.1 - 0.11 12.3 0.7 0.15 11.9 0.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain HMGL-like PF00682.19 ETS64617.1 - 1.5e-80 270.6 0.8 2.3e-80 270.0 0.8 1.3 1 0 0 1 1 1 1 HMGL-like Alk_phosphatase PF00245.20 ETS64618.1 - 2.5e-91 306.7 0.1 3.1e-91 306.4 0.1 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Myosin_head PF00063.21 ETS64619.1 - 5.7e-239 794.8 4.3 7.1e-239 794.5 4.3 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ETS64619.1 - 1.8e-52 177.8 0.1 3.2e-52 176.9 0.1 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.6 ETS64619.1 - 6.2e-11 42.0 0.1 1.5e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ETS64619.1 - 6.9e-10 38.4 1.7 1e-09 37.8 0.4 2.0 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ETS64619.1 - 7.4e-09 35.2 0.1 1.6e-07 30.9 0.0 2.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_3 PF08239.11 ETS64619.1 - 0.0012 19.1 0.9 0.003 17.8 0.9 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain AAA_22 PF13401.6 ETS64619.1 - 0.034 14.4 0.0 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 ETS64619.1 - 0.063 12.8 0.8 9 5.8 0.0 3.0 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 ETS64619.1 - 0.075 13.4 0.0 0.29 11.5 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ETS64619.1 - 0.18 11.7 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain GHMP_kinases_C PF08544.13 ETS64619.1 - 0.42 11.0 2.7 0.38 11.1 0.2 2.2 2 0 0 2 2 2 0 GHMP kinases C terminal Helicase_C PF00271.31 ETS64620.1 - 2.8e-17 63.1 0.0 7e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 ETS64620.1 - 2.1e-15 56.9 3.1 2.8e-15 56.5 0.1 2.6 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETS64620.1 - 7.3e-11 42.3 0.0 1.5e-10 41.3 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ETS64620.1 - 1.9e-10 40.8 0.0 4.7e-10 39.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETS64620.1 - 8.2e-05 22.9 0.0 0.00026 21.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ETS64620.1 - 0.0053 16.1 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 KaiC ResIII PF04851.15 ETS64620.1 - 0.017 15.1 0.0 0.063 13.3 0.0 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DUF494 PF04361.13 ETS64620.1 - 0.022 14.7 0.0 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF494) T2SSE PF00437.20 ETS64620.1 - 0.028 13.5 0.0 0.13 11.3 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein PhoH PF02562.16 ETS64620.1 - 0.079 12.4 0.6 0.18 11.2 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 ETS64620.1 - 0.37 11.2 2.6 0.74 10.2 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain Astacin PF01400.24 ETS64621.1 - 7.4e-09 35.5 0.0 2.2e-08 33.9 0.0 1.8 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 ETS64621.1 - 0.0017 18.2 0.6 0.0075 16.1 0.6 2.0 1 1 0 1 1 1 1 Matrixin TMEM171 PF15471.6 ETS64621.1 - 0.01 14.9 2.5 0.02 13.9 2.5 1.4 1 0 0 1 1 1 0 Transmembrane protein family 171 Peptidase_M43 PF05572.13 ETS64621.1 - 0.038 13.9 0.1 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A Reprolysin_4 PF13583.6 ETS64621.1 - 0.13 11.8 7.5 0.36 10.4 0.1 3.5 3 0 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 ETS64621.1 - 0.27 11.4 6.1 0.089 12.9 0.4 2.7 2 0 0 2 2 2 0 Metallo-peptidase family M12 Glyco_hydro_39 PF01229.17 ETS64623.1 - 8.5e-06 24.6 0.0 1.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 Cul7 PF11515.8 ETS64623.1 - 0.051 13.9 0.1 7.6 6.9 0.0 2.4 2 0 0 2 2 2 0 Mouse development and cellular proliferation protein Cullin-7 Astacin PF01400.24 ETS64624.1 - 1.7e-09 37.5 0.3 5.1e-09 36.0 0.3 1.8 1 1 0 1 1 1 1 Astacin (Peptidase family M12A) Peptidase_M10 PF00413.24 ETS64624.1 - 6.2e-07 29.4 0.1 0.037 13.9 0.0 2.3 2 0 0 2 2 2 2 Matrixin Peptidase_M43 PF05572.13 ETS64624.1 - 0.00081 19.3 0.0 0.0017 18.3 0.0 1.5 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 ETS64624.1 - 2.2 8.4 6.2 5.6 7.1 4.6 2.5 2 1 0 2 2 2 0 Metallo-peptidase family M12 DUF4267 PF14087.6 ETS64625.1 - 7.9e-05 22.7 0.6 9e-05 22.5 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4267) MFS_1 PF07690.16 ETS64626.1 - 7.5e-13 48.1 24.1 7.5e-13 48.1 24.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Sporozoite_P67 PF05642.11 ETS64628.1 - 0.24 9.5 2.9 0.43 8.6 2.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Melibiase_2 PF16499.5 ETS64629.1 - 4.9e-53 180.1 1.1 1.6e-52 178.5 1.1 1.8 1 1 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ETS64629.1 - 1.7e-11 44.0 0.0 3.2e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ETS64629.1 - 3e-09 36.3 0.1 5.8e-09 35.3 0.1 1.4 1 0 0 1 1 1 1 Melibiase Raffinose_syn PF05691.12 ETS64629.1 - 0.00075 17.4 0.1 0.0011 16.9 0.1 1.2 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Alginate_lyase PF05426.12 ETS64630.1 - 3e-12 46.7 5.5 6.9e-12 45.5 5.5 1.4 1 1 0 1 1 1 1 Alginate lyase Tricho_coat PF05892.11 ETS64630.1 - 0.063 13.0 0.0 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 Trichovirus coat protein COesterase PF00135.28 ETS64631.1 - 2.2e-91 307.3 0.0 2.6e-91 307.0 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETS64631.1 - 1.9e-05 24.6 0.1 0.0002 21.3 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETS64631.1 - 0.057 12.9 0.1 0.09 12.2 0.1 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Alginate_lyase PF05426.12 ETS64632.1 - 0.1 12.1 3.1 0.21 11.1 2.8 1.7 1 1 0 1 1 1 0 Alginate lyase Glyco_hydro_88 PF07470.13 ETS64633.1 - 5.7e-09 35.5 0.0 1e-08 34.7 0.0 1.5 1 1 0 1 1 1 1 Glycosyl Hydrolase Family 88 Glyco_hydro_43 PF04616.14 ETS64634.1 - 0.0052 16.1 1.9 0.0054 16.1 0.3 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 43 Glyco_hydro_32N PF00251.20 ETS64634.1 - 0.0083 15.7 0.6 0.43 10.1 0.7 2.2 1 1 1 2 2 2 2 Glycosyl hydrolases family 32 N-terminal domain DUF1467 PF07330.12 ETS64634.1 - 0.04 13.8 0.0 0.078 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) MFS_1 PF07690.16 ETS64635.1 - 2.7e-33 115.4 24.6 3.4e-33 115.0 24.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 ETS64635.1 - 0.0051 16.2 29.0 0.18 11.0 29.0 2.4 1 1 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB DUF3278 PF11683.8 ETS64635.1 - 0.51 10.4 4.3 0.57 10.3 0.7 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3278) Fungal_trans PF04082.18 ETS64636.1 - 2.6e-20 72.6 0.0 4.6e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS64636.1 - 1.3e-08 34.8 11.7 1.3e-08 34.8 11.7 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Glyco_hydro_28 PF00295.17 ETS64637.1 - 1.7e-13 50.4 0.0 3.5e-13 49.3 0.0 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 ETS64637.1 - 0.012 15.4 5.4 0.1 12.4 5.5 2.4 1 1 0 1 1 1 0 Right handed beta helix region Alginate_lyase PF05426.12 ETS64638.1 - 2.9e-17 63.1 0.0 6.6e-17 61.9 0.0 1.5 1 1 0 1 1 1 1 Alginate lyase Nucleolin_bd PF16725.5 ETS64638.1 - 0.18 11.5 0.0 4.9 6.9 0.0 2.8 3 0 0 3 3 3 0 Nucleolin binding domain RTA1 PF04479.13 ETS64639.1 - 1.4e-42 145.7 9.8 2e-42 145.1 9.8 1.3 1 0 0 1 1 1 1 RTA1 like protein Zn_clus PF00172.18 ETS64642.1 - 0.086 13.0 6.6 0.14 12.3 6.6 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF333 PF03891.15 ETS64643.1 - 6e-52 173.6 0.1 4.7e-25 87.5 0.0 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF333) cNMP_binding PF00027.29 ETS64643.1 - 0.01 15.9 0.0 0.076 13.1 0.0 1.9 1 1 1 2 2 2 0 Cyclic nucleotide-binding domain Glyco_transf_15 PF01793.16 ETS64643.1 - 0.017 14.4 0.0 0.54 9.5 0.0 2.0 2 0 0 2 2 2 0 Glycolipid 2-alpha-mannosyltransferase DUF4318 PF14201.6 ETS64643.1 - 0.021 15.3 0.0 3.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) m04gp34like PF12216.8 ETS64643.1 - 0.043 13.4 0.0 4.5 6.8 0.0 2.2 1 1 1 2 2 2 0 Immune evasion protein CIDE-N PF02017.15 ETS64643.1 - 0.1 12.6 0.7 1.8 8.7 0.1 2.6 2 2 0 2 2 2 0 CIDE-N domain Sel_put PF04328.13 ETS64643.1 - 0.15 12.1 0.4 6.3 6.9 0.1 2.2 2 0 0 2 2 2 0 Selenoprotein, putative DUF3712 PF12505.8 ETS64644.1 - 1.5e-87 290.1 30.7 3.5e-17 62.8 0.0 9.5 11 0 0 11 11 11 6 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ETS64644.1 - 3.8e-06 27.4 21.4 0.49 11.0 0.0 9.9 11 1 0 11 11 11 4 Late embryogenesis abundant protein NDC10_II PF16787.5 ETS64645.1 - 0.00031 19.9 0.0 0.12 11.4 0.0 3.5 3 1 0 3 3 3 2 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GMC_oxred_N PF00732.19 ETS64646.1 - 1.6e-60 205.0 0.0 2.2e-60 204.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS64646.1 - 6.3e-35 120.8 0.0 1e-34 120.1 0.0 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ETS64646.1 - 6.5e-05 22.2 0.0 0.17 10.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ETS64646.1 - 0.0012 18.5 1.2 0.065 12.8 1.2 3.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS64646.1 - 0.0012 19.0 0.0 0.0028 17.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETS64646.1 - 0.017 14.3 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 ETS64646.1 - 0.084 11.7 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_2 PF07992.14 ETS64646.1 - 0.093 11.9 0.0 0.31 10.2 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ELFV_dehydrog PF00208.21 ETS64647.1 - 6.1e-80 268.4 2.2 7.7e-80 268.1 2.2 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ETS64647.1 - 1.1e-46 157.9 0.0 2.9e-46 156.6 0.0 1.7 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 ETS64647.1 - 0.13 12.7 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding B12D PF06522.11 ETS64648.1 - 9.2e-23 79.8 0.1 1.2e-22 79.5 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit PS_Dcarbxylase PF02666.15 ETS64649.1 - 3.7e-52 176.8 0.0 6.7e-52 176.0 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 ETS64649.1 - 1.9e-35 121.2 0.1 2.4e-16 59.9 0.0 3.7 4 0 0 4 4 4 3 C2 domain EF-hand_6 PF13405.6 ETS64649.1 - 7.2e-05 22.4 1.5 0.05 13.6 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain Nop14 PF04147.12 ETS64649.1 - 0.12 10.5 7.6 0.18 10.0 7.6 1.1 1 0 0 1 1 1 0 Nop14-like family UBZ_FAAP20 PF15750.5 ETS64649.1 - 0.19 11.7 1.8 0.45 10.5 1.8 1.6 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger BUD22 PF09073.10 ETS64649.1 - 0.94 8.8 12.8 1.8 7.8 12.8 1.4 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ETS64649.1 - 1.7 8.0 8.3 2.6 7.4 8.3 1.2 1 0 0 1 1 1 0 SDA1 YL1 PF05764.13 ETS64649.1 - 3.5 7.7 6.2 7 6.7 6.2 1.5 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 ETS64649.1 - 6.2 5.0 7.0 9.4 4.4 7.0 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF1764 PF08576.10 ETS64650.1 - 3.7e-17 63.0 11.3 5.5e-12 46.5 11.3 2.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) Mif2_N PF15624.6 ETS64650.1 - 4.5 8.0 13.3 6.9 7.4 13.3 1.2 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal GREB1 PF15782.5 ETS64650.1 - 5.7 3.9 8.0 6.4 3.8 8.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 ETS64650.1 - 8.8 4.7 12.6 9.6 4.6 12.6 1.0 1 0 0 1 1 1 0 Macoilin family TPR_1 PF00515.28 ETS64651.1 - 1.1e-08 34.5 2.1 1.2e-05 24.9 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETS64651.1 - 3.1e-08 33.1 5.3 0.00013 21.9 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETS64651.1 - 5.6e-05 23.7 6.9 9.3e-05 23.0 4.5 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETS64651.1 - 0.00073 20.0 7.6 0.012 16.1 3.3 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETS64651.1 - 0.0014 18.8 4.9 0.0066 16.7 2.8 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETS64651.1 - 0.0016 18.7 0.6 0.27 11.7 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETS64651.1 - 0.0095 15.9 0.1 0.034 14.2 0.1 2.0 2 0 0 2 2 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS64651.1 - 0.013 15.7 1.2 0.026 14.7 0.5 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETS64651.1 - 0.018 15.2 2.5 0.018 15.2 2.5 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 ETS64651.1 - 0.023 15.3 0.9 0.17 12.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETS64651.1 - 0.058 14.0 6.9 0.26 12.0 0.2 3.2 3 1 1 4 4 3 0 Tetratricopeptide repeat FAT PF02259.23 ETS64651.1 - 0.064 12.5 0.0 0.078 12.2 0.0 1.2 1 0 0 1 1 1 0 FAT domain TPR_14 PF13428.6 ETS64651.1 - 0.086 13.7 4.5 0.11 13.4 1.5 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETS64651.1 - 0.2 11.6 3.5 0.71 9.8 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat ATG16 PF08614.11 ETS64651.1 - 0.73 10.0 5.0 0.06 13.6 0.4 1.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) PALP PF00291.25 ETS64652.1 - 2.6e-57 194.5 0.1 2e-39 135.8 0.0 2.0 2 0 0 2 2 2 2 Pyridoxal-phosphate dependent enzyme AA_permease_2 PF13520.6 ETS64653.1 - 2.4e-53 181.5 44.9 2.9e-53 181.2 44.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETS64653.1 - 9.4e-17 60.8 46.3 2.7e-16 59.3 46.4 1.6 1 1 0 1 1 1 1 Amino acid permease ADH_N PF08240.12 ETS64654.1 - 2e-29 101.6 0.6 3.6e-29 100.8 0.2 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS64654.1 - 2.1e-26 92.4 0.5 3.1e-26 91.9 0.5 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETS64654.1 - 1.5e-05 26.0 0.2 2.5e-05 25.3 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Aminotran_4 PF01063.19 ETS64656.1 - 1.7e-17 64.0 0.0 2.2e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV vATP-synt_AC39 PF01992.16 ETS64657.1 - 1.2e-111 373.5 0.0 1.4e-111 373.3 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit SEN1_N PF12726.7 ETS64658.1 - 5.1e-162 540.8 4.2 7.6e-162 540.3 4.2 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 ETS64658.1 - 5.7e-67 226.3 0.3 5.7e-67 226.3 0.3 2.3 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 ETS64658.1 - 1e-60 204.8 0.0 2e-60 203.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETS64658.1 - 1.9e-10 41.2 0.0 1.2e-09 38.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETS64658.1 - 5.1e-07 29.6 3.5 0.00013 21.8 0.3 2.8 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ETS64658.1 - 0.00019 21.3 0.7 0.81 9.4 0.0 3.4 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Zn_clus PF00172.18 ETS64658.1 - 0.00027 21.0 9.5 0.00027 21.0 9.5 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain IMUP PF15761.5 ETS64658.1 - 0.0024 18.5 3.0 0.0024 18.5 3.0 4.0 3 0 0 3 3 3 1 Immortalisation up-regulated protein UvrD_C_2 PF13538.6 ETS64658.1 - 0.0028 17.5 0.0 0.0068 16.2 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Fungal_trans PF04082.18 ETS64658.1 - 0.027 13.5 0.0 0.056 12.5 0.0 1.4 1 0 0 1 1 1 0 Fungal specific transcription factor domain UvrD-helicase PF00580.21 ETS64658.1 - 0.027 14.0 0.1 0.96 8.9 0.1 2.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain AAA_22 PF13401.6 ETS64658.1 - 0.03 14.6 0.8 8.6 6.6 0.2 3.6 3 0 0 3 3 3 0 AAA domain LegC3_N PF18654.1 ETS64658.1 - 0.076 12.2 1.3 0.16 11.1 1.3 1.5 1 0 0 1 1 1 0 LegC3 N-terminal coiled-coil domain UvrD_C PF13361.6 ETS64658.1 - 0.13 11.6 0.0 0.31 10.4 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Helicase_RecD PF05127.14 ETS64658.1 - 0.24 11.2 3.2 1.8 8.4 0.0 3.0 3 0 0 3 3 3 0 Helicase DUF2054 PF10218.9 ETS64658.1 - 0.29 11.2 5.5 0.33 11.1 3.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2054) Sugar_tr PF00083.24 ETS64659.1 - 9.3e-35 120.4 29.0 1.6e-33 116.2 29.0 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS64659.1 - 1.1e-17 64.0 47.5 4.8e-10 38.9 20.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 ETS64661.1 - 3.7e-53 180.6 0.0 3.4e-52 177.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Transket_pyr PF02779.24 ETS64661.1 - 2.2e-40 138.2 0.0 4e-40 137.4 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ETS64661.1 - 1.3e-28 99.4 0.0 3.5e-28 98.0 0.0 1.8 1 1 0 1 1 1 1 Transketolase, C-terminal domain Ribosomal_L10 PF00466.20 ETS64661.1 - 0.00018 21.6 0.0 0.0004 20.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L10 WD40 PF00400.32 ETS64662.1 - 5.3e-27 93.5 16.6 3.8e-05 24.4 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64662.1 - 3.4e-19 68.9 0.7 9.7e-05 22.6 0.0 6.0 1 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETS64662.1 - 0.00012 22.0 0.0 0.046 13.6 0.0 3.4 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETS64662.1 - 0.0033 16.2 3.4 0.087 11.4 0.5 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETS64662.1 - 0.024 14.6 0.1 90 3.2 0.0 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETS64662.1 - 0.05 12.1 1.1 0.51 8.8 0.5 2.0 1 1 0 2 2 2 0 Cytochrome D1 heme domain RAB3GAP2_N PF14655.6 ETS64662.1 - 0.087 12.1 0.0 1.1 8.4 0.0 2.5 3 0 0 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ge1_WD40 PF16529.5 ETS64662.1 - 0.089 11.7 0.7 6.2 5.7 0.0 3.6 2 1 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS3_N PF14761.6 ETS64662.1 - 0.11 12.1 0.0 6.1 6.3 0.0 2.4 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 NDK PF00334.19 ETS64663.1 - 2.7e-56 189.3 0.0 3.3e-56 189.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase AOX PF01786.17 ETS64664.1 - 1.5e-100 335.2 0.4 1.9e-100 334.8 0.4 1.1 1 0 0 1 1 1 1 Alternative oxidase COQ7 PF03232.13 ETS64664.1 - 0.0083 15.9 0.2 0.31 10.8 0.0 2.5 2 1 0 2 2 2 1 Ubiquinone biosynthesis protein COQ7 Ribosomal_L34e PF01199.18 ETS64665.1 - 5.5e-41 138.8 5.1 7.1e-41 138.4 5.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e Cytochrome_C7 PF14522.6 ETS64665.1 - 0.024 14.6 0.6 0.051 13.6 0.6 1.4 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c FhuF_C PF11575.8 ETS64665.1 - 0.18 11.8 2.8 5.8 6.9 0.3 2.5 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain Ribosomal_L6 PF00347.23 ETS64666.1 - 1.2e-18 67.5 0.6 1.6e-11 44.7 0.0 3.7 3 1 0 3 3 3 2 Ribosomal protein L6 R3H-assoc PF13902.6 ETS64667.1 - 0.052 13.9 0.3 0.052 13.9 0.3 2.6 2 0 0 2 2 2 0 R3H-associated N-terminal domain G_path_suppress PF15991.5 ETS64668.1 - 5.7 7.0 15.6 8.2 6.5 15.6 1.2 1 0 0 1 1 1 0 G-protein pathway suppressor DUF953 PF06110.11 ETS64669.1 - 2.8e-13 49.5 0.0 3.1e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 ETS64669.1 - 5e-05 23.2 0.1 6.1e-05 23.0 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_9 PF14595.6 ETS64669.1 - 0.0038 17.0 0.1 0.0046 16.7 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin UDG PF03167.19 ETS64670.1 - 5.8e-19 68.6 0.3 1.9e-15 57.2 0.0 3.0 2 1 0 2 2 2 1 Uracil DNA glycosylase superfamily Hamartin PF04388.12 ETS64670.1 - 8.4 4.9 8.8 11 4.5 8.8 1.2 1 0 0 1 1 1 0 Hamartin protein Aldedh PF00171.22 ETS64671.1 - 1.8e-182 607.0 0.4 2e-182 606.8 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETS64671.1 - 0.00094 18.7 0.0 0.31 10.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) LuxC PF05893.14 ETS64671.1 - 0.011 14.8 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) OPT PF03169.15 ETS64672.1 - 3.6e-100 336.4 41.0 4.3e-100 336.1 41.0 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DNase_NucA_NucB PF14040.6 ETS64673.1 - 2.5e-27 95.5 4.3 3.7e-27 95.0 4.3 1.3 1 0 0 1 1 1 1 Deoxyribonuclease NucA/NucB ADH_N PF08240.12 ETS64674.1 - 1.4e-23 82.9 0.3 2.4e-23 82.1 0.3 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETS64674.1 - 1e-12 48.2 0.0 1.7e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ETS64674.1 - 0.028 13.7 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ETS64674.1 - 0.034 13.5 0.0 0.077 12.3 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.6 ETS64674.1 - 0.074 13.6 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain 3HCDH_N PF02737.18 ETS64674.1 - 0.077 12.9 0.0 0.24 11.3 0.0 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ADH_zinc_N_2 PF13602.6 ETS64674.1 - 0.14 13.2 0.0 0.24 12.5 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DNA_pol_E_B PF04042.16 ETS64675.1 - 4.5e-44 150.3 0.2 7.5e-44 149.6 0.2 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Glyco_hydro_18 PF00704.28 ETS64676.1 - 2.2e-16 60.5 0.9 3.6e-16 59.8 0.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Zn_clus PF00172.18 ETS64677.1 - 6.1e-05 23.1 10.1 0.00013 22.0 10.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain HbrB PF08539.11 ETS64679.1 - 4.7e-52 176.4 0.0 9.2e-52 175.4 0.0 1.5 1 0 0 1 1 1 1 HbrB-like His_Phos_1 PF00300.22 ETS64679.1 - 4.1e-34 118.0 0.0 7.3e-34 117.2 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ras PF00071.22 ETS64680.1 - 2.7e-20 72.6 0.0 3.5e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS64680.1 - 7.8e-11 42.2 0.0 1.2e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Mg_chelatase PF01078.21 ETS64680.1 - 0.0035 16.8 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETS64680.1 - 0.0039 16.9 0.2 0.0073 16.0 0.2 1.5 1 1 0 1 1 1 1 Sigma-54 interaction domain NACHT PF05729.12 ETS64680.1 - 0.0047 16.9 0.1 0.032 14.1 0.1 2.0 2 0 0 2 2 2 1 NACHT domain Gtr1_RagA PF04670.12 ETS64680.1 - 0.005 16.2 0.0 0.0064 15.9 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 ETS64680.1 - 0.0069 16.7 0.1 0.024 14.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ETS64680.1 - 0.0076 16.0 0.2 0.027 14.2 0.1 1.9 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 ETS64680.1 - 0.011 15.9 0.0 0.018 15.1 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Arf PF00025.21 ETS64680.1 - 0.014 14.8 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Zeta_toxin PF06414.12 ETS64680.1 - 0.022 14.0 0.1 0.047 13.0 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin KAP_NTPase PF07693.14 ETS64680.1 - 0.026 13.8 0.0 0.026 13.8 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain TsaE PF02367.17 ETS64680.1 - 0.029 14.4 0.1 0.061 13.3 0.1 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE G-alpha PF00503.20 ETS64680.1 - 0.048 12.8 0.6 0.067 12.3 0.1 1.5 2 0 0 2 2 2 0 G-protein alpha subunit MMR_HSR1 PF01926.23 ETS64680.1 - 0.05 13.7 0.2 0.083 13.0 0.2 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ETS64680.1 - 0.052 13.3 0.3 0.4 10.4 0.1 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 ETS64680.1 - 0.068 12.9 0.1 0.32 10.7 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 ETS64680.1 - 0.11 12.5 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETS64680.1 - 0.13 12.9 0.2 0.26 11.8 0.1 1.8 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETS64680.1 - 0.15 11.6 0.3 0.21 11.1 0.3 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Pox_A32 PF04665.12 ETS64680.1 - 0.17 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein Caleosin PF05042.13 ETS64681.1 - 1.2e-63 214.0 0.1 1.8e-63 213.5 0.1 1.1 1 0 0 1 1 1 1 Caleosin related protein Pkinase PF00069.25 ETS64682.1 - 3.8e-19 69.1 0.0 2.9e-17 62.9 0.0 2.9 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64682.1 - 5.2e-07 29.2 0.0 1.9e-06 27.4 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ETS64682.1 - 0.0011 18.9 0.4 0.0032 17.4 0.1 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ETS64682.1 - 0.0091 15.1 0.0 0.014 14.4 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 ETS64682.1 - 0.033 13.5 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETS64682.1 - 0.13 11.8 0.0 0.39 10.3 0.0 1.6 2 0 0 2 2 2 0 RIO1 family MIT PF04212.18 ETS64683.1 - 0.019 15.0 1.4 0.079 13.0 0.0 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Inositol_P PF00459.25 ETS64684.1 - 1e-62 212.1 0.2 1.2e-62 211.9 0.2 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family OPT PF03169.15 ETS64685.1 - 1.2e-138 463.4 17.6 1.5e-138 463.1 17.6 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Topoisom_bac PF01131.20 ETS64685.1 - 6.9e-100 334.9 0.0 8.5e-100 334.6 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase zf-GRF PF06839.12 ETS64685.1 - 7.5e-20 70.8 12.5 2.8e-11 43.3 2.6 2.6 2 0 0 2 2 2 2 GRF zinc finger Toprim PF01751.22 ETS64685.1 - 6e-19 68.2 0.0 1.6e-18 66.8 0.0 1.8 1 0 0 1 1 1 1 Toprim domain zf-CCHC PF00098.23 ETS64685.1 - 1.5e-12 47.0 14.0 7.4e-07 29.0 3.0 2.6 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 ETS64685.1 - 1.9e-06 27.7 8.1 0.0039 17.1 0.7 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_5 PF14787.6 ETS64685.1 - 3.5e-06 26.6 11.7 0.00098 18.8 0.9 2.5 2 0 0 2 2 2 2 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 ETS64685.1 - 3.5e-05 23.5 12.7 0.0053 16.5 3.4 2.5 2 0 0 2 2 2 2 Zinc knuckle Phage_holin_2_1 PF04971.12 ETS64685.1 - 0.014 15.4 0.4 3.2 7.8 0.0 2.8 2 0 0 2 2 2 0 Bacteriophage P21 holin S PhyH PF05721.13 ETS64686.1 - 3.1e-47 161.6 0.0 4.8e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Alpha-amylase_N PF02903.14 ETS64686.1 - 0.083 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Alpha amylase, N-terminal ig-like domain 2OG-FeII_Oxy_5 PF13759.6 ETS64686.1 - 0.095 13.1 0.0 0.21 12.0 0.0 1.6 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase PALP PF00291.25 ETS64687.1 - 4e-34 118.4 0.0 9.1e-33 113.9 0.0 2.2 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Rhodanese PF00581.20 ETS64687.1 - 7.7e-06 26.4 0.1 0.00076 20.0 0.1 2.6 1 1 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 ETS64688.1 - 1.7e-56 191.6 0.1 3.1e-35 121.8 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64688.1 - 4.5e-24 85.1 0.2 3.1e-16 59.4 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETS64688.1 - 0.0082 15.1 0.1 0.013 14.5 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ETS64688.1 - 0.01 15.2 0.0 0.035 13.4 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Pkinase_C PF00433.24 ETS64688.1 - 0.075 13.7 0.0 0.31 11.8 0.0 2.2 1 0 0 1 1 1 0 Protein kinase C terminal domain DUF1028 PF06267.12 ETS64688.1 - 0.097 12.4 0.3 0.18 11.5 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF1028) RIO1 PF01163.22 ETS64688.1 - 0.15 11.7 0.6 0.97 9.0 0.0 2.3 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 ETS64688.1 - 1.8 8.4 9.8 0.13 12.1 0.2 3.3 3 1 0 3 3 3 0 Phosphotransferase enzyme family Glyco_hydro_31 PF01055.26 ETS64689.1 - 1.9e-126 422.9 3.6 2.9e-126 422.2 3.6 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ETS64689.1 - 1.1e-24 86.9 0.0 2.3e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ETS64689.1 - 0.017 15.4 0.1 0.042 14.2 0.1 1.7 1 0 0 1 1 1 0 Galactose mutarotase-like HAMP PF00672.25 ETS64690.1 - 1.3e-37 128.0 18.6 4.3e-08 33.4 0.4 9.1 8 2 1 9 9 9 6 HAMP domain HATPase_c PF02518.26 ETS64690.1 - 1e-27 96.8 0.1 3.4e-27 95.2 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ETS64690.1 - 9.5e-25 86.9 0.9 6.5e-24 84.3 0.8 2.4 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ETS64690.1 - 5.4e-16 58.4 1.9 2.1e-15 56.5 0.3 3.1 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain DUF3829 PF12889.7 ETS64690.1 - 0.055 12.9 0.7 13 5.1 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF3829) SpoIIID PF12116.8 ETS64690.1 - 0.26 11.4 1.3 25 5.1 0.0 4.3 6 0 0 6 6 6 0 Stage III sporulation protein D Rab5-bind PF09311.11 ETS64690.1 - 0.54 9.6 8.9 5.8 6.2 0.1 4.4 3 2 2 5 5 5 0 Rabaptin-like protein ApoLp-III PF07464.11 ETS64690.1 - 7.9 6.6 18.0 8 6.5 0.1 6.0 3 2 3 7 7 7 0 Apolipophorin-III precursor (apoLp-III) SKG6 PF08693.10 ETS64691.1 - 1.3e-07 30.9 0.2 2.7e-07 29.9 0.2 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM51 PF15345.6 ETS64691.1 - 0.0032 17.4 2.7 0.0032 17.4 2.7 1.9 2 1 0 2 2 2 1 Transmembrane protein 51 TMEM154 PF15102.6 ETS64691.1 - 0.013 15.4 0.1 0.061 13.2 0.0 2.1 1 1 1 2 2 2 0 TMEM154 protein family PilJ PF13675.6 ETS64691.1 - 0.049 13.7 1.9 0.14 12.2 1.9 1.8 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Yippee-Mis18 PF03226.14 ETS64692.1 - 1.5e-13 50.8 0.1 2e-13 50.5 0.1 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-IS66 PF13005.7 ETS64692.1 - 0.078 13.4 1.4 0.78 10.2 0.0 2.2 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 XPA_C PF05181.12 ETS64693.1 - 5.4e-23 80.7 1.9 9.1e-23 80.0 1.9 1.4 1 0 0 1 1 1 1 XPA protein C-terminus DZR PF12773.7 ETS64693.1 - 0.04 13.9 0.7 7.9 6.6 0.1 2.5 2 0 0 2 2 2 0 Double zinc ribbon DUF1451 PF07295.11 ETS64693.1 - 0.09 12.8 0.4 0.09 12.8 0.4 2.9 4 0 0 4 4 4 0 Zinc-ribbon containing domain Nudix_N_2 PF14803.6 ETS64693.1 - 1.8 8.5 5.7 21 5.1 0.1 3.4 3 0 0 3 3 3 0 Nudix N-terminal XPA_N PF01286.18 ETS64693.1 - 2.5 8.2 5.8 0.69 10.0 1.7 2.3 2 1 0 2 2 2 0 XPA protein N-terminal Glyco_hydro_63 PF03200.16 ETS64694.1 - 3.5e-163 543.9 0.0 2.9e-162 540.9 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 ETS64694.1 - 1.6e-70 237.8 0.0 2.7e-70 237.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 ETS64694.1 - 8.9e-07 28.1 0.1 1.5e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 Trehalase Bac_rhamnosid6H PF17389.2 ETS64694.1 - 0.0057 15.9 0.1 0.014 14.7 0.1 1.6 1 1 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain SMI1_KNR4 PF09346.10 ETS64695.1 - 9.2e-26 90.8 0.0 1.6e-25 90.1 0.0 1.4 1 0 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) zf-met2 PF12907.7 ETS64696.1 - 1.5e-14 53.8 1.2 2.5e-14 53.1 1.2 1.4 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 ETS64696.1 - 1.6e-07 32.1 14.0 2.2e-07 31.6 14.0 1.2 1 0 0 1 1 1 1 4F5 protein family zf-C2H2_12 PF18658.1 ETS64696.1 - 0.017 14.7 0.1 0.024 14.2 0.1 1.2 1 0 0 1 1 1 0 Zinc-finger C2H2-type Eapp_C PF10238.9 ETS64696.1 - 0.059 13.4 1.3 0.068 13.3 1.3 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Ferric_reduct PF01794.19 ETS64698.1 - 5.7e-17 62.0 9.7 5.7e-17 62.0 9.7 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ETS64698.1 - 3.2e-16 59.4 0.0 9.2e-14 51.5 0.0 2.4 1 1 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 ETS64698.1 - 1.7e-13 51.0 0.0 5.3e-11 42.9 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Peptidase_A22B PF04258.13 ETS64699.1 - 2.6e-79 266.7 5.1 3.6e-79 266.3 5.1 1.1 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 ETS64699.1 - 1e-07 31.7 5.3 1.5e-07 31.1 5.3 1.4 1 0 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease CENP-B_dimeris PF09026.10 ETS64699.1 - 0.00087 19.6 1.9 0.00087 19.6 1.9 2.4 2 0 0 2 2 2 1 Centromere protein B dimerisation domain FAM176 PF14851.6 ETS64699.1 - 0.034 13.8 5.5 1.1 9.0 1.3 2.6 2 0 0 2 2 2 0 FAM176 family PBP1_TM PF14812.6 ETS64699.1 - 0.32 11.4 9.8 0.24 11.8 0.7 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DnaJ_C PF01556.18 ETS64700.1 - 1.2e-41 142.2 0.5 1.7e-41 141.8 0.5 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ETS64700.1 - 5.3e-20 71.3 1.2 9e-20 70.6 1.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ETS64700.1 - 4.5e-17 62.2 20.1 7.4e-17 61.5 20.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ETS64700.1 - 0.0043 17.0 10.0 0.031 14.2 1.1 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein TackOD1 PF18551.1 ETS64700.1 - 0.33 10.6 7.0 0.56 9.9 1.9 2.2 1 1 0 2 2 2 0 Thaumarchaeal output domain 1 HypA PF01155.19 ETS64700.1 - 0.83 9.7 11.3 4 7.5 3.4 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 ETS64700.1 - 7.2 6.7 9.9 85 3.2 9.6 2.2 1 1 0 1 1 1 0 zinc-ribbons Glyco_hydro_25 PF01183.20 ETS64701.1 - 1.7e-45 155.4 0.1 1.9e-45 155.2 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 SIS PF01380.22 ETS64702.1 - 1.4e-16 60.5 0.0 4.1e-16 59.0 0.0 1.7 2 0 0 2 2 2 1 SIS domain SIS_2 PF13580.6 ETS64702.1 - 7.5e-08 32.5 0.0 0.0041 17.1 0.0 2.5 1 1 1 2 2 2 2 SIS domain MFS_1 PF07690.16 ETS64704.1 - 4e-41 141.1 36.1 4e-41 141.1 36.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64704.1 - 5.2e-14 51.9 7.8 5.2e-14 51.9 7.8 2.3 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_4 PF06779.14 ETS64704.1 - 5.9e-08 32.4 6.2 5.9e-08 32.4 6.2 2.6 3 0 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB UNC-93 PF05978.16 ETS64704.1 - 0.64 9.7 8.1 0.049 13.3 2.2 2.1 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 YTH PF04146.15 ETS64705.1 - 3.1e-40 137.8 0.0 6.2e-40 136.9 0.0 1.5 1 0 0 1 1 1 1 YT521-B-like domain PapG_N PF03627.13 ETS64705.1 - 0.13 11.9 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 PapG carbohydrate binding domain ThiF PF00899.21 ETS64707.1 - 1e-57 195.3 0.0 1.7e-57 194.6 0.0 1.2 1 0 0 1 1 1 1 ThiF family RabGAP-TBC PF00566.18 ETS64707.1 - 3.7e-33 115.0 0.0 2.6e-16 59.9 0.0 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Rhodanese PF00581.20 ETS64707.1 - 1.2e-06 29.0 0.1 6.4e-06 26.6 0.0 2.3 2 1 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 ETS64707.1 - 0.00049 20.2 0.0 0.0013 18.8 0.0 1.7 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ETS64707.1 - 0.058 13.8 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Sacchrp_dh_NADP PF03435.18 ETS64707.1 - 0.074 13.3 0.6 0.34 11.2 0.6 2.0 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HycI PF01750.18 ETS64707.1 - 0.23 11.3 0.0 0.45 10.4 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase maturation protease LRS4 PF10422.9 ETS64707.1 - 0.4 10.2 1.8 20 4.7 0.1 2.3 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 EspB PF05802.11 ETS64707.1 - 5.2 7.0 8.2 41 4.1 6.3 2.4 2 0 0 2 2 2 0 Enterobacterial EspB protein TFIIIC_delta PF12657.7 ETS64708.1 - 2.2e-10 40.8 0.2 6.3e-10 39.3 0.2 1.7 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 ETS64708.1 - 0.012 15.6 0.3 0.032 14.2 0.3 1.6 1 0 0 1 1 1 0 Putative zinc-finger of transcription factor IIIC complex GATase PF00117.28 ETS64709.1 - 2.7e-05 24.0 0.0 0.00013 21.8 0.0 1.9 2 0 0 2 2 2 1 Glutamine amidotransferase class-I DnaJ-X PF14308.6 ETS64710.1 - 4.4e-67 225.6 1.0 4.4e-67 225.6 1.0 2.8 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 ETS64710.1 - 3.6e-18 65.4 0.2 3.6e-18 65.4 0.2 2.2 2 0 0 2 2 2 1 DnaJ domain PAT1 PF09770.9 ETS64710.1 - 0.0011 17.3 5.9 0.0015 16.9 5.9 1.1 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 Microtub_bd PF16796.5 ETS64710.1 - 0.068 13.1 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Microtubule binding PIN_12 PF16289.5 ETS64710.1 - 0.66 10.4 7.8 1.9 8.9 7.8 1.8 1 0 0 1 1 1 0 PIN domain PIF1 PF05970.14 ETS64711.1 - 8.8e-61 206.1 0.4 9.8e-49 166.4 0.1 2.2 2 0 0 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 ETS64711.1 - 1.7e-26 93.1 0.3 4e-26 91.9 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.6 ETS64711.1 - 6.6e-13 49.2 0.0 7.1e-12 45.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 ETS64711.1 - 2.3e-06 27.9 0.0 1e-05 25.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETS64711.1 - 7.3e-05 22.4 0.0 0.00015 21.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 ETS64711.1 - 7.6e-05 23.2 0.5 0.0004 20.8 0.1 2.3 2 1 0 2 2 2 1 AAA ATPase domain Viral_helicase1 PF01443.18 ETS64711.1 - 0.00014 21.7 0.0 0.024 14.4 0.1 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 ETS64711.1 - 0.0003 21.2 0.2 0.00086 19.7 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) UvrD_C_2 PF13538.6 ETS64711.1 - 0.003 17.3 1.5 0.015 15.1 0.1 2.7 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain ABC_tran PF00005.27 ETS64711.1 - 0.0036 17.8 0.0 0.012 16.1 0.0 1.8 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 ETS64711.1 - 0.0056 16.6 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF2075 PF09848.9 ETS64711.1 - 0.0064 15.8 0.1 0.016 14.5 0.1 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 ETS64711.1 - 0.0067 15.5 0.0 0.014 14.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein NTPase_1 PF03266.15 ETS64711.1 - 0.0081 16.1 0.1 0.53 10.2 0.0 2.7 2 0 0 2 2 2 1 NTPase TrwB_AAD_bind PF10412.9 ETS64711.1 - 0.012 14.6 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 ETS64711.1 - 0.013 15.6 0.0 0.085 12.9 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_32 PF13654.6 ETS64711.1 - 0.02 13.7 0.0 0.04 12.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETS64711.1 - 0.021 14.8 0.0 0.06 13.4 0.0 1.7 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 ETS64711.1 - 0.021 14.8 0.2 0.38 10.7 0.2 2.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ETS64711.1 - 0.021 14.5 0.1 0.077 12.7 0.1 2.0 1 1 0 1 1 1 0 Sigma-54 interaction domain NB-ARC PF00931.22 ETS64711.1 - 0.026 13.7 0.1 0.044 13.0 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain Mg_chelatase PF01078.21 ETS64711.1 - 0.027 13.9 0.0 0.06 12.7 0.0 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ETS64711.1 - 0.03 14.7 0.0 0.083 13.3 0.0 1.8 1 1 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 ETS64711.1 - 0.036 14.0 0.2 0.13 12.2 0.2 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 ETS64711.1 - 0.042 13.6 3.0 0.079 12.7 0.0 2.7 4 0 0 4 4 2 0 AAA domain PhoH PF02562.16 ETS64711.1 - 0.051 13.0 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein MMR_HSR1 PF01926.23 ETS64711.1 - 0.052 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Herpes_Helicase PF02689.14 ETS64711.1 - 0.059 11.3 0.1 0.29 9.0 0.0 1.9 2 0 0 2 2 2 0 Helicase SH3_13 PF18335.1 ETS64711.1 - 0.069 13.0 0.1 0.36 10.7 0.0 2.2 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain Helicase_RecD PF05127.14 ETS64711.1 - 0.077 12.9 0.4 0.36 10.7 0.4 2.1 1 1 0 1 1 1 0 Helicase UvrD-helicase PF00580.21 ETS64711.1 - 0.11 12.0 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Phage_TTP_1 PF04630.12 ETS64711.1 - 0.18 11.1 0.2 0.35 10.1 0.2 1.4 1 0 0 1 1 1 0 Phage tail tube protein DUF5605 PF18310.1 ETS64711.1 - 0.2 11.6 0.0 0.76 9.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5605) Cys_Met_Meta_PP PF01053.20 ETS64712.1 - 8.1e-55 185.9 0.1 1.4e-46 158.8 0.1 2.6 2 1 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ETS64712.1 - 0.0034 16.6 0.0 0.0051 16.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ETS64712.1 - 0.021 13.8 0.2 0.034 13.1 0.2 1.3 1 0 0 1 1 1 0 Aminotransferase class-V zf-C2H2 PF00096.26 ETS64713.1 - 0.093 13.2 0.9 0.2 12.2 0.2 2.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF2420 PF10336.9 ETS64716.1 - 2.6e-16 59.6 0.0 5.2e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Thiolase_N PF00108.23 ETS64717.1 - 3.7e-76 255.9 4.6 5.7e-76 255.3 4.6 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETS64717.1 - 2.8e-42 143.2 0.7 2.8e-42 143.2 0.7 1.7 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 ETS64717.1 - 0.0039 17.3 0.1 0.014 15.5 0.1 2.0 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 ETS64717.1 - 0.0048 16.5 2.5 0.0071 16.0 0.4 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain CENP-T_C PF15511.6 ETS64718.1 - 7.6e-08 32.5 0.1 9.2e-08 32.2 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ETS64718.1 - 0.00021 21.4 0.1 0.00032 20.8 0.1 1.5 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ETS64718.1 - 0.00047 20.5 0.0 0.00062 20.1 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ETS64718.1 - 0.00062 20.1 0.1 0.0007 20.0 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ETS64718.1 - 0.00091 19.5 0.1 0.0019 18.5 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ETS64718.1 - 0.05 13.7 0.0 0.056 13.5 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Reprolysin_5 PF13688.6 ETS64719.1 - 4.6e-43 147.7 9.0 4.6e-43 147.7 9.0 2.8 3 0 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 ETS64719.1 - 2.7e-40 138.4 5.4 6.7e-40 137.1 5.4 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ETS64719.1 - 8.3e-38 130.1 3.6 2.9e-37 128.3 3.6 2.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 ETS64719.1 - 1e-15 58.2 25.7 1e-15 58.2 25.7 4.3 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 ETS64719.1 - 9.3e-12 45.6 0.1 3.1e-11 43.9 0.1 2.0 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.19 ETS64719.1 - 2.7e-07 30.7 8.2 2.6e-05 24.2 8.2 2.9 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Pep_M12B_propep PF01562.19 ETS64719.1 - 9.1e-07 29.2 0.3 1.7e-06 28.3 0.3 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR_2 PF17771.1 ETS64719.1 - 5.3e-05 23.7 10.3 5.3e-05 23.7 10.3 3.9 2 1 2 4 4 4 1 ADAM cysteine-rich domain Peptidase_M66 PF10462.9 ETS64719.1 - 0.027 13.4 0.1 0.046 12.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Cyclin PF08613.11 ETS64720.1 - 1.3e-35 123.1 0.0 3.4e-23 82.8 0.0 3.8 4 1 1 5 5 5 2 Cyclin HMG_box PF00505.19 ETS64722.1 - 6.5e-12 45.7 2.5 1.1e-11 45.0 2.5 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS64722.1 - 0.00023 21.7 0.2 0.00048 20.7 0.2 1.6 1 0 0 1 1 1 1 HMG-box domain PAP1 PF08601.10 ETS64722.1 - 0.00027 20.8 9.3 0.00027 20.8 9.3 2.6 3 1 0 3 3 3 1 Transcription factor PAP1 DHC PF09626.10 ETS64722.1 - 0.0044 17.9 0.3 1 10.2 0.0 2.4 2 0 0 2 2 2 1 Dihaem cytochrome c MATalpha_HMGbox PF04769.12 ETS64722.1 - 0.18 11.1 0.0 0.32 10.3 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box Ribosomal_S4e PF00900.20 ETS64723.1 - 2.6e-36 123.4 0.1 6.1e-36 122.2 0.1 1.7 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 ETS64723.1 - 3.8e-22 77.7 0.1 7.3e-22 76.7 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 ETS64723.1 - 9.9e-08 32.0 0.1 2.3e-07 30.8 0.1 1.7 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 ETS64723.1 - 2.5e-05 23.9 0.0 5.6e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 ETS64723.1 - 5.8e-05 22.9 5.1 6.1e-05 22.8 2.9 2.3 2 0 0 2 2 2 1 KOW motif DUF4224 PF13986.6 ETS64723.1 - 0.074 13.0 0.4 1.8 8.5 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4224) MFS_1 PF07690.16 ETS64724.1 - 1.5e-09 37.3 23.6 1.5e-09 37.3 23.6 3.9 4 1 0 4 4 4 2 Major Facilitator Superfamily DUF2939 PF11159.8 ETS64724.1 - 0.021 15.2 0.0 0.072 13.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) Sin3a_C PF16879.5 ETS64725.1 - 6.9e-79 265.5 0.0 4.2e-78 263.0 0.0 2.3 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 ETS64725.1 - 4.8e-42 141.8 7.1 3.9e-18 65.3 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 ETS64725.1 - 2.2e-41 139.8 0.8 4.9e-41 138.8 0.1 2.0 2 0 0 2 2 2 1 Sin3 family co-repressor Ribosomal_S21e PF01249.18 ETS64726.1 - 3.6e-34 116.7 0.0 5.9e-34 116.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S21e MFS_1 PF07690.16 ETS64727.1 - 1.4e-30 106.5 26.4 1.4e-30 106.5 26.4 1.3 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64727.1 - 0.00074 18.5 25.6 0.0037 16.2 25.6 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter Phi-29_GP16_7 PF06720.11 ETS64727.1 - 0.21 11.5 0.1 0.52 10.2 0.0 1.7 2 0 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 MARVEL PF01284.23 ETS64728.1 - 0.00081 19.4 19.5 0.034 14.2 6.1 3.2 2 1 1 3 3 3 3 Membrane-associating domain DUF4064 PF13273.6 ETS64728.1 - 0.15 12.4 9.1 1.3 9.4 0.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Cytochrom_C PF00034.21 ETS64729.1 - 1.3e-10 42.3 0.0 1.7e-10 41.9 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ETS64729.1 - 2.4e-08 34.2 1.7 1.3e-07 31.8 1.7 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 ETS64729.1 - 0.00017 21.3 1.3 0.0011 18.6 1.3 2.3 1 1 0 1 1 1 1 Cytochrome c-550 domain Peptidase_M13_N PF05649.13 ETS64730.1 - 1.8e-94 317.6 0.0 2.7e-94 317.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 ETS64730.1 - 7e-57 192.3 0.0 1.1e-56 191.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M13 SRP54 PF00448.22 ETS64732.1 - 6.1e-76 254.4 0.2 1.1e-75 253.5 0.2 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ETS64732.1 - 2.6e-30 105.0 0.1 2.6e-30 105.0 0.1 4.0 3 1 0 3 3 3 1 Signal peptide binding domain SRP54_N PF02881.19 ETS64732.1 - 6.2e-17 61.6 0.4 1.9e-16 60.0 0.4 1.9 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 ETS64732.1 - 8.9e-06 25.4 0.3 5.3e-05 22.9 0.3 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 ETS64732.1 - 4.8e-05 23.5 0.0 0.00012 22.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ETS64732.1 - 0.002 18.6 0.5 0.0081 16.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETS64732.1 - 0.0051 17.2 0.1 0.028 14.8 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETS64732.1 - 0.013 15.7 0.2 0.06 13.6 0.0 2.2 3 0 0 3 3 3 0 AAA domain CbiA PF01656.23 ETS64732.1 - 0.029 14.4 0.0 0.086 12.9 0.0 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 ETS64732.1 - 0.03 14.2 0.0 0.071 13.0 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B APS_kinase PF01583.20 ETS64732.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Zeta_toxin PF06414.12 ETS64732.1 - 0.045 13.0 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_30 PF13604.6 ETS64732.1 - 0.052 13.3 1.0 0.14 11.9 0.0 2.2 2 1 1 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 ETS64732.1 - 0.064 13.3 0.7 0.38 10.9 0.2 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ETS64732.1 - 0.074 12.8 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein MeaB PF03308.16 ETS64732.1 - 0.096 11.6 0.0 0.096 11.6 0.0 2.7 3 1 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_28 PF13521.6 ETS64732.1 - 0.1 12.8 0.0 0.36 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 ETS64732.1 - 0.11 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_18 PF13238.6 ETS64732.1 - 0.14 12.7 0.0 0.32 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_8 PF12780.7 ETS64732.1 - 0.17 11.1 0.4 5.6 6.2 0.0 2.7 3 0 0 3 3 3 0 P-loop containing dynein motor region D4 Vps55 PF04133.14 ETS64733.1 - 2.6e-43 146.7 6.3 3e-43 146.5 6.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF2040 PF09745.9 ETS64734.1 - 3.9e-36 123.8 19.8 3.9e-36 123.8 19.8 2.9 2 1 0 2 2 2 1 Coiled-coil domain-containing protein 55 (DUF2040) Rot1 PF10681.9 ETS64735.1 - 6.8e-55 185.8 1.8 8.4e-55 185.5 1.8 1.1 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal VanZ PF04892.12 ETS64736.1 - 4.1e-05 24.2 0.7 6.8e-05 23.5 0.7 1.5 1 1 0 1 1 1 1 VanZ like family DUF4203 PF13886.6 ETS64736.1 - 0.018 14.7 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4203) Cyclin_N PF00134.23 ETS64738.1 - 3.3e-14 52.7 0.0 8e-14 51.5 0.0 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ETS64738.1 - 2e-08 34.7 0.2 2e-08 34.7 0.2 2.1 3 0 0 3 3 3 1 Cyclin BTB PF00651.31 ETS64740.1 - 0.16 12.2 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain CwfJ_C_2 PF04676.14 ETS64741.1 - 5.6e-25 88.1 0.1 1.7e-24 86.6 0.1 1.9 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 ETS64741.1 - 6.9e-25 87.3 0.0 1.1e-24 86.7 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Aconitase PF00330.20 ETS64742.1 - 2.3e-148 495.0 0.0 3e-148 494.6 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ETS64742.1 - 6.2e-33 113.9 0.0 1.2e-32 113.0 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain MRP-L28 PF09812.9 ETS64742.1 - 1.6e-05 25.1 1.3 0.0013 18.9 0.4 2.3 2 0 0 2 2 2 2 Mitochondrial ribosomal protein L28 RdRP PF05183.12 ETS64743.1 - 3.8e-117 392.4 0.0 6.4e-117 391.6 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase SAP PF02037.27 ETS64744.1 - 5.4e-05 22.8 0.3 0.00012 21.7 0.3 1.5 1 0 0 1 1 1 1 SAP domain Polysacc_deac_1 PF01522.21 ETS64745.1 - 8.2e-28 96.8 0.0 1.5e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Ran_BP1 PF00638.18 ETS64749.1 - 3.3e-17 62.9 0.9 6.5e-17 61.9 0.9 1.5 1 0 0 1 1 1 1 RanBP1 domain HAT PF02184.16 ETS64750.1 - 6.9e-17 61.1 58.6 8.1e-09 35.3 0.0 14.0 14 1 0 14 14 14 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ETS64750.1 - 6.2e-13 48.4 47.2 0.0052 17.5 0.0 12.8 8 4 6 14 14 14 5 Tetratricopeptide repeat Suf PF05843.14 ETS64750.1 - 1.1e-12 48.6 21.0 0.0043 17.1 0.1 6.8 2 2 4 6 6 6 4 Suppressor of forked protein (Suf) TPR_2 PF07719.17 ETS64750.1 - 3e-12 45.6 8.4 0.024 14.7 0.1 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS64750.1 - 9.7e-11 42.0 15.0 0.00092 19.7 0.1 7.7 7 2 1 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETS64750.1 - 8.1e-08 31.9 7.6 0.015 15.5 0.1 7.8 7 1 2 9 9 9 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETS64750.1 - 1.9e-07 30.6 0.6 0.59 10.1 0.0 6.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETS64750.1 - 3.2e-07 30.3 0.2 0.00044 20.4 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ETS64750.1 - 5.6e-05 23.1 17.2 0.0093 15.9 2.8 6.5 5 2 1 6 6 6 2 Mad3/BUB1 homology region 1 Fis1_TPR_C PF14853.6 ETS64750.1 - 0.00028 20.9 2.2 0.29 11.2 0.0 4.3 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat U3_assoc_6 PF08640.11 ETS64750.1 - 0.002 18.1 15.2 1.5 8.9 0.0 6.9 6 2 1 8 8 8 1 U3 small nucleolar RNA-associated protein 6 FGAR-AT_linker PF18072.1 ETS64750.1 - 0.12 12.9 0.0 10 6.8 0.0 3.0 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain GCIP PF13324.6 ETS64750.1 - 0.23 11.1 2.6 0.51 9.9 2.6 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting TPR_11 PF13414.6 ETS64750.1 - 0.44 10.3 7.9 2.2 8.0 0.0 5.0 6 0 0 6 6 6 0 TPR repeat TPR_6 PF13174.6 ETS64750.1 - 0.96 10.2 25.1 6.6 7.6 0.0 9.2 10 1 1 11 11 8 0 Tetratricopeptide repeat SET PF00856.28 ETS64751.1 - 2.5e-20 73.5 2.5 3.2e-19 69.9 0.0 3.1 2 0 0 2 2 2 1 SET domain N-SET PF11764.8 ETS64751.1 - 4.8e-11 43.1 1.4 4.8e-11 43.1 1.4 4.4 2 2 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET_assoc PF11767.8 ETS64751.1 - 6.1e-08 32.2 0.0 1.2e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 Histone lysine methyltransferase SET associated LSM PF01423.22 ETS64752.1 - 1.5e-14 53.4 0.1 1.9e-14 53.1 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ETS64752.1 - 0.037 13.7 0.0 0.068 12.8 0.0 1.6 1 1 0 1 1 1 0 Hfq protein Arf PF00025.21 ETS64753.1 - 2.3e-71 238.8 0.0 3.1e-71 238.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETS64753.1 - 2.6e-14 53.5 0.0 4.4e-14 52.7 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETS64753.1 - 8.5e-12 45.0 0.0 1.2e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ETS64753.1 - 4.1e-11 42.6 0.2 3.5e-06 26.4 0.1 2.6 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ETS64753.1 - 1.7e-10 40.6 0.0 2.5e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETS64753.1 - 1.5e-08 34.3 0.0 1.9e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS64753.1 - 0.00035 20.6 0.0 0.00078 19.5 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETS64754.1 - 1.2e-33 116.5 0.0 2.6e-33 115.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ETS64754.1 - 5.1e-32 111.6 13.8 9.4e-32 110.7 13.8 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ETS64754.1 - 2.1e-05 24.1 0.1 0.00078 18.9 0.1 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETS64754.1 - 4e-05 24.1 2.0 6.3e-05 23.4 0.2 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETS64754.1 - 0.0012 19.1 0.1 0.012 15.9 0.1 2.4 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETS64754.1 - 0.012 15.5 0.0 0.025 14.5 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_15 PF13175.6 ETS64754.1 - 0.013 15.2 0.0 0.024 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 ETS64754.1 - 0.017 14.8 0.0 0.075 12.8 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_21 PF13304.6 ETS64754.1 - 0.027 14.3 0.0 0.061 13.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETS64754.1 - 0.028 14.2 0.1 0.086 12.6 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 ETS64754.1 - 0.031 14.7 0.0 0.28 11.6 0.0 2.4 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ETS64754.1 - 0.036 13.3 0.0 0.074 12.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Methyltransf_23 PF13489.6 ETS64754.1 - 0.16 11.8 0.0 0.57 10.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain MTABC_N PF16185.5 ETS64754.1 - 0.65 9.5 5.9 0.32 10.5 0.2 3.2 3 2 1 4 4 4 0 Mitochondrial ABC-transporter N-terminal five TM region DUF2408 PF10303.9 ETS64755.1 - 3.1e-52 176.7 5.1 1.6e-38 132.3 0.0 4.5 3 2 1 4 4 4 4 Protein of unknown function (DUF2408) Imm5 PF14423.6 ETS64755.1 - 0.11 12.7 0.5 0.26 11.5 0.5 1.6 1 0 0 1 1 1 0 Immunity protein Imm5 DUF724 PF05266.14 ETS64755.1 - 0.14 12.0 1.1 0.27 11.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Copper-fist PF00649.18 ETS64757.1 - 1.7e-14 53.0 2.7 6e-14 51.3 2.7 2.0 1 0 0 1 1 1 1 Copper fist DNA binding domain RED_N PF07808.13 ETS64758.1 - 1e-10 41.6 3.7 1.8e-10 40.8 3.3 1.6 1 1 0 1 1 1 1 RED-like protein N-terminal region Phos_pyr_kin PF08543.12 ETS64759.1 - 1.2e-10 41.2 0.0 1.9e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ETS64759.1 - 8.5e-08 31.9 0.0 1.6e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF1690 PF07956.11 ETS64760.1 - 2.6e-29 102.4 6.2 4.3e-29 101.7 6.2 1.3 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) TolA_bind_tri PF16331.5 ETS64760.1 - 0.018 15.1 3.8 2.9 8.0 0.2 3.0 2 1 0 2 2 2 0 TolA binding protein trimerisation STAT_int PF02865.17 ETS64760.1 - 0.027 14.9 0.4 0.1 13.0 0.1 2.0 1 1 1 2 2 2 0 STAT protein, protein interaction domain DUF5631 PF18645.1 ETS64760.1 - 0.11 12.8 0.0 0.42 11.0 0.0 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5631) Piwi PF02171.17 ETS64760.1 - 0.12 11.6 0.1 0.21 10.8 0.1 1.3 1 0 0 1 1 1 0 Piwi domain Seryl_tRNA_N PF02403.22 ETS64760.1 - 0.16 12.2 4.8 0.36 11.1 4.8 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF737 PF05300.11 ETS64760.1 - 0.19 12.1 7.5 0.46 10.8 7.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF737) DUF4407 PF14362.6 ETS64760.1 - 0.34 10.2 8.8 0.48 9.7 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliT PF05400.13 ETS64760.1 - 8.8 7.2 9.0 42 5.1 2.2 3.2 4 0 0 4 4 4 0 Flagellar protein FliT CENP-N PF05238.13 ETS64761.1 - 2.8e-70 237.7 0.0 3.5e-70 237.4 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Pinin_SDK_N PF04697.13 ETS64761.1 - 0.5 11.0 3.9 0.24 12.1 0.8 2.1 3 0 0 3 3 3 0 pinin/SDK conserved region ArgJ PF01960.18 ETS64762.1 - 1.4e-135 451.9 0.1 1.6e-135 451.6 0.1 1.0 1 0 0 1 1 1 1 ArgJ family Thioredoxin_8 PF13905.6 ETS64763.1 - 3.4e-09 36.9 0.0 7.2e-08 32.7 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like Aminotran_1_2 PF00155.21 ETS64764.1 - 1.6e-30 106.5 0.0 2e-30 106.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aldo_ket_red PF00248.21 ETS64765.1 - 1.1e-32 113.4 0.0 4.5e-32 111.4 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family DUF21 PF01595.20 ETS64766.1 - 1.4e-36 125.8 0.3 2.4e-36 125.1 0.3 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETS64766.1 - 0.0074 16.7 0.4 9.3 6.8 0.0 3.6 3 0 0 3 3 3 2 CBS domain zf-C2HE PF16278.5 ETS64767.1 - 8e-12 45.4 0.1 1.8e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 ETS64767.1 - 1.9e-11 44.6 2.0 2.2e-05 25.1 0.8 2.4 2 0 0 2 2 2 2 HIT domain DcpS_C PF11969.8 ETS64767.1 - 4.5e-11 43.2 4.3 1.3e-05 25.7 2.4 2.4 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding Sprouty PF05210.13 ETS64768.1 - 0.67 10.4 4.6 6.8 7.1 0.0 3.3 3 0 0 3 3 3 0 Sprouty protein (Spry) CoA_trans PF01144.23 ETS64769.1 - 3.1e-107 356.9 1.8 2.9e-64 216.4 0.0 2.0 2 0 0 2 2 2 2 Coenzyme A transferase AcetylCoA_hyd_C PF13336.6 ETS64769.1 - 0.00049 20.1 0.1 0.0011 18.9 0.1 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain DeoRC PF00455.22 ETS64769.1 - 0.051 13.5 0.0 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 DeoR C terminal sensor domain SUI1 PF01253.22 ETS64770.1 - 5.4e-27 94.1 2.0 1e-26 93.3 2.0 1.4 1 0 0 1 1 1 1 Translation initiation factor SUI1 GATA PF00320.27 ETS64771.1 - 1.2e-13 50.5 3.7 2.1e-13 49.6 3.7 1.5 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 ETS64771.1 - 1.1e-08 35.2 0.1 2.9e-07 30.7 0.0 2.7 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 ETS64771.1 - 2.9e-08 33.7 0.1 2.6e-07 30.6 0.0 2.4 3 0 0 3 3 3 1 PAS fold PAS_9 PF13426.7 ETS64771.1 - 2e-06 28.0 0.0 6.6e-06 26.3 0.0 1.9 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ETS64771.1 - 2.7e-06 27.6 0.0 8.3e-06 26.0 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_11 PF14598.6 ETS64771.1 - 0.0001 22.4 0.2 0.00024 21.2 0.0 1.6 2 0 0 2 2 2 1 PAS domain TF_Zn_Ribbon PF08271.12 ETS64771.1 - 0.079 12.5 0.4 0.35 10.4 0.0 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding UBX PF00789.20 ETS64772.1 - 7.6e-12 45.3 0.0 1.7e-11 44.2 0.0 1.6 1 0 0 1 1 1 1 UBX domain Thioredoxin_7 PF13899.6 ETS64772.1 - 0.00018 21.6 0.0 0.00039 20.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like DUF874 PF05917.11 ETS64772.1 - 1.3 7.9 4.6 2.1 7.3 4.6 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) WD40 PF00400.32 ETS64773.1 - 2.7e-33 113.5 18.8 3.7e-06 27.6 0.1 11.4 12 0 0 12 12 12 7 WD domain, G-beta repeat Utp12 PF04003.12 ETS64773.1 - 1.5e-19 70.3 0.0 2.5e-19 69.6 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 ETS64773.1 - 1.2e-16 60.8 0.0 0.0057 16.9 0.0 9.3 3 2 7 10 10 10 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS64773.1 - 4.6e-06 25.8 4.3 6.9 5.5 0.1 5.7 3 3 2 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETS64773.1 - 0.0025 16.5 0.0 3.5 6.1 0.0 3.5 2 1 1 3 3 3 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETS64773.1 - 0.0043 16.4 0.0 0.75 9.1 0.0 3.0 4 0 0 4 4 4 1 WD40-like domain Cytochrom_D1 PF02239.16 ETS64773.1 - 0.0075 14.8 0.0 6.9 5.1 0.0 3.2 3 0 0 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETS64773.1 - 0.0092 14.9 0.0 3.9 6.3 0.1 2.7 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain DUF1513 PF07433.11 ETS64773.1 - 0.065 12.3 0.2 2.5 7.1 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1513) YjeF_N PF03853.15 ETS64774.1 - 6.7e-32 110.7 0.0 8.5e-32 110.4 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus RabGAP-TBC PF00566.18 ETS64775.1 - 5e-34 117.9 2.2 1.5e-33 116.3 2.2 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF3123 PF11321.8 ETS64775.1 - 4.6 7.9 5.2 3 8.6 1.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) PQQ_2 PF13360.6 ETS64776.1 - 0.0044 16.6 1.8 0.06 12.9 1.7 2.3 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.6 ETS64776.1 - 0.067 13.7 0.1 0.067 13.7 0.1 3.8 4 1 0 4 4 4 0 PQQ-like domain PQQ PF01011.21 ETS64776.1 - 3 7.9 4.8 3.6 7.7 0.3 3.3 3 1 1 4 4 4 0 PQQ enzyme repeat NMT PF01233.19 ETS64777.1 - 6.6e-74 247.1 0.0 1e-73 246.5 0.0 1.3 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain NMT_C PF02799.15 ETS64777.1 - 7.4e-73 244.5 0.0 3.7e-72 242.2 0.0 2.0 2 1 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Acetyltransf_9 PF13527.7 ETS64777.1 - 0.00066 19.8 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETS64777.1 - 0.0021 18.3 0.0 0.0054 17.0 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PBP1_TM PF14812.6 ETS64777.1 - 0.011 16.1 8.5 0.022 15.1 8.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myc_N PF01056.18 ETS64777.1 - 0.018 15.0 9.2 0.037 13.9 9.2 1.5 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.12 ETS64777.1 - 0.039 13.3 10.3 0.066 12.5 10.3 1.3 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 ETS64777.1 - 0.16 12.1 17.4 0.27 11.3 17.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein FRG2 PF15315.6 ETS64777.1 - 0.56 10.4 12.2 0.064 13.5 7.3 1.9 2 0 0 2 2 2 0 Facioscapulohumeral muscular dystrophy candidate 2 CDC45 PF02724.14 ETS64777.1 - 0.72 8.1 10.1 1.1 7.5 10.1 1.3 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 ETS64777.1 - 1.5 8.9 6.6 3.4 7.7 6.6 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal PPP4R2 PF09184.11 ETS64777.1 - 1.5 8.3 13.9 0.096 12.3 8.4 1.7 2 0 0 2 2 2 0 PPP4R2 DNA_pol_phi PF04931.13 ETS64777.1 - 2.1 6.3 13.2 3.3 5.7 13.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ETS64777.1 - 2.4 8.6 14.6 7.5 7.0 14.6 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETS64777.1 - 3.6 7.3 8.1 9 5.9 8.1 1.7 1 0 0 1 1 1 0 FAM176 family PGA2 PF07543.12 ETS64777.1 - 3.7 7.5 16.2 0.15 12.1 9.8 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 G-patch PF01585.23 ETS64778.1 - 4.2e-11 42.6 6.5 1e-10 41.3 6.0 1.8 1 1 1 2 2 2 2 G-patch domain G-patch_2 PF12656.7 ETS64778.1 - 5.8e-06 26.3 0.5 1.1e-05 25.4 0.5 1.4 1 0 0 1 1 1 1 G-patch domain zf-C2H2_jaz PF12171.8 ETS64778.1 - 0.0025 18.0 0.5 0.0038 17.5 0.5 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ETS64778.1 - 0.063 13.6 0.3 0.1 12.9 0.3 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ETS64778.1 - 0.11 13.3 0.3 0.23 12.4 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ETS64778.1 - 0.12 12.1 0.3 0.22 11.3 0.3 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2 PF00096.26 ETS64778.1 - 0.22 12.0 0.3 0.47 11.0 0.3 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type SAM_2 PF07647.17 ETS64779.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) FA_desaturase PF00487.24 ETS64781.1 - 6.2e-25 88.5 18.9 6.2e-25 88.5 18.9 1.9 2 0 0 2 2 2 1 Fatty acid desaturase Lipid_DES PF08557.10 ETS64781.1 - 1.4e-18 66.0 0.9 2.5e-18 65.3 0.9 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) WD40 PF00400.32 ETS64782.1 - 3.2e-17 62.6 8.3 1.6e-05 25.6 1.2 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64782.1 - 1.1e-07 32.1 0.0 1.7 9.0 0.0 4.9 2 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS64782.1 - 0.043 12.8 0.3 0.24 10.3 0.0 2.4 2 2 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup_retrotrp_bd PF10599.9 ETS64782.1 - 3.9 8.2 7.5 7.3 7.3 1.6 3.2 1 1 2 3 3 3 0 Retro-transposon transporting motif DUF2407_C PF13373.6 ETS64783.1 - 1.1e-13 51.6 12.1 1e-12 48.4 1.3 3.7 3 1 0 3 3 3 2 DUF2407 C-terminal domain DUF2407 PF10302.9 ETS64783.1 - 9.3e-06 26.2 0.7 0.00019 21.9 0.2 2.9 2 1 0 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 ETS64783.1 - 0.0069 16.1 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family ChaC PF04752.12 ETS64784.1 - 1.5e-51 175.0 0.0 2.7e-51 174.1 0.0 1.4 1 0 0 1 1 1 1 ChaC-like protein DnaJ PF00226.31 ETS64784.1 - 4e-25 87.7 4.1 1.1e-24 86.3 4.1 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 ETS64784.1 - 1.3e-10 41.2 3.0 1.4e-08 34.8 0.6 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETS64784.1 - 1.7e-07 31.4 4.6 3e-06 27.4 0.3 3.1 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ETS64784.1 - 3.3e-06 27.3 0.1 0.014 15.8 0.1 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ETS64784.1 - 0.0026 18.4 1.4 0.52 11.3 0.1 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETS64784.1 - 0.0059 17.0 2.9 0.46 11.0 0.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type LUC7 PF03194.15 ETS64785.1 - 4.3e-71 239.5 1.2 9.3e-71 238.4 1.2 1.5 1 0 0 1 1 1 1 LUC7 N_terminus DIM1 PF02966.16 ETS64785.1 - 9e-64 213.2 0.1 1.4e-63 212.5 0.1 1.3 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 ETS64785.1 - 0.17 11.9 0.1 0.33 11.0 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin PI3K_1B_p101 PF10486.9 ETS64785.1 - 8 4.1 7.0 14 3.3 7.0 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Nitroreductase PF00881.24 ETS64786.1 - 7.5e-10 39.1 0.0 9.6e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family COX6B PF02297.17 ETS64787.1 - 2.3e-16 59.8 4.6 7.3e-16 58.2 3.0 2.1 2 0 0 2 2 2 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.14 ETS64787.1 - 0.022 14.7 0.2 0.033 14.1 0.2 1.3 1 0 0 1 1 1 0 APOBEC-like C-terminal domain mRNA_stabil PF13929.6 ETS64787.1 - 0.083 11.9 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 mRNA stabilisation HoxA13_N PF12284.8 ETS64787.1 - 0.74 10.5 6.5 0.93 10.1 6.0 1.6 1 1 0 1 1 1 0 Hox protein A13 N terminal Prp18 PF02840.15 ETS64788.1 - 2.2e-61 206.1 0.0 4.1e-61 205.2 0.0 1.5 1 0 0 1 1 1 1 Prp18 domain PRP4 PF08799.11 ETS64788.1 - 4.1e-11 42.2 5.6 1.1e-10 40.9 5.6 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like BNIP3 PF06553.12 ETS64788.1 - 0.16 11.6 7.0 0.3 10.7 7.0 1.4 1 0 0 1 1 1 0 BNIP3 Pex2_Pex12 PF04757.14 ETS64789.1 - 9.1e-43 146.4 1.6 1.1e-42 146.1 1.6 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 ETS64789.1 - 6.8e-09 35.9 9.1 1e-08 35.4 9.1 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETS64789.1 - 8e-08 32.5 7.4 1.4e-07 31.7 7.4 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETS64789.1 - 1.4e-05 24.8 6.2 2.1e-05 24.3 6.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS64789.1 - 3.1e-05 23.7 8.9 5.1e-05 23.0 8.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS64789.1 - 0.00096 19.1 2.3 0.002 18.1 0.8 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETS64789.1 - 0.0011 18.7 7.7 0.0018 18.1 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETS64789.1 - 0.0017 18.0 2.7 0.0034 17.1 2.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-ANAPC11 PF12861.7 ETS64789.1 - 0.0018 18.3 3.9 0.003 17.6 3.9 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ETS64789.1 - 0.0091 15.9 6.8 0.014 15.3 6.8 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-Nse PF11789.8 ETS64789.1 - 0.11 12.4 2.3 0.2 11.5 2.3 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 ETS64789.1 - 0.12 12.2 6.8 0.2 11.5 6.8 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ETS64789.1 - 4.6 7.5 7.9 1.6 9.0 3.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING USP7_ICP0_bdg PF12436.8 ETS64790.1 - 9.9e-87 290.2 2.9 1.6e-86 289.5 1.4 2.0 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 ETS64790.1 - 1e-64 218.1 2.8 2.4e-63 213.6 1.5 2.7 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 ETS64790.1 - 3.1e-50 171.1 0.0 5.4e-50 170.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETS64790.1 - 5.6e-21 75.5 0.0 1.3e-20 74.3 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ETS64790.1 - 3.8e-09 36.7 0.0 9e-08 32.3 0.0 2.9 2 1 1 3 3 3 1 MATH domain Rad60-SLD PF11976.8 ETS64790.1 - 0.057 13.3 1.2 0.67 9.8 0.0 3.3 4 1 0 4 4 4 0 Ubiquitin-2 like Rad60 SUMO-like EF_assoc_1 PF08355.12 ETS64793.1 - 1.1e-32 111.4 0.1 9.8e-32 108.4 0.0 2.3 2 0 0 2 2 2 1 EF hand associated Ras PF00071.22 ETS64793.1 - 4.5e-31 107.6 0.0 3.8e-20 72.1 0.0 2.1 2 0 0 2 2 2 2 Ras family EF_assoc_2 PF08356.12 ETS64793.1 - 8.4e-28 96.2 0.0 9.1e-27 92.9 0.0 2.4 1 1 0 1 1 1 1 EF hand associated Roc PF08477.13 ETS64793.1 - 1.7e-17 63.7 0.0 9e-10 38.8 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_7 PF13499.6 ETS64793.1 - 4.3e-09 36.7 0.5 0.0014 19.0 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain pair MMR_HSR1 PF01926.23 ETS64793.1 - 8.1e-09 35.6 0.0 5.1e-05 23.3 0.0 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 ETS64793.1 - 8.8e-09 34.3 2.2 0.0037 16.7 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETS64793.1 - 3.1e-08 32.9 1.6 0.0058 16.5 0.2 2.6 2 0 0 2 2 2 2 EF-hand domain Arf PF00025.21 ETS64793.1 - 1.4e-05 24.7 0.0 0.059 12.8 0.0 3.1 2 1 0 2 2 2 2 ADP-ribosylation factor family EF-hand_5 PF13202.6 ETS64793.1 - 8.9e-05 21.8 4.2 0.05 13.1 0.5 2.6 2 0 0 2 2 2 2 EF hand AAA_18 PF13238.6 ETS64793.1 - 0.00012 22.6 0.0 0.018 15.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain SRPRB PF09439.10 ETS64793.1 - 0.0003 20.3 0.0 0.81 9.1 0.0 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ETS64793.1 - 0.00039 20.7 0.0 0.81 10.0 0.0 2.6 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ETS64793.1 - 0.0031 17.4 0.1 0.77 9.6 0.0 3.4 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 ETS64793.1 - 0.0032 17.0 0.0 1.5 8.3 0.0 3.1 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain NOG1 PF06858.14 ETS64793.1 - 0.0061 16.3 0.2 0.54 10.1 0.1 2.5 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) AAA_16 PF13191.6 ETS64793.1 - 0.0071 16.7 0.0 3.4 8.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain PduV-EutP PF10662.9 ETS64793.1 - 0.0076 16.0 0.0 0.21 11.3 0.0 2.6 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ETS64793.1 - 0.0096 15.8 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA_25 PF13481.6 ETS64793.1 - 0.011 15.4 0.0 0.43 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain EF-hand_8 PF13833.6 ETS64793.1 - 0.012 15.4 0.7 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain pair AAA_19 PF13245.6 ETS64793.1 - 0.018 15.4 0.0 0.39 11.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ETS64793.1 - 0.019 14.7 0.0 0.91 9.2 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Dynamin_N PF00350.23 ETS64793.1 - 0.026 14.6 0.2 7.2 6.6 0.0 2.6 2 1 1 3 3 3 0 Dynamin family ATP_bind_1 PF03029.17 ETS64793.1 - 0.029 14.2 0.5 10 5.8 0.0 3.6 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 ETS64793.1 - 0.038 14.2 0.0 4.5 7.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETS64793.1 - 0.047 13.4 0.1 5.5 6.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ETS64793.1 - 0.048 13.4 0.1 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ETS64793.1 - 0.055 13.6 0.1 2.8 8.1 0.1 2.5 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ETS64793.1 - 0.057 12.7 0.1 0.29 10.3 0.1 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) EF-hand_10 PF14788.6 ETS64793.1 - 0.059 13.2 2.6 0.15 12.0 0.2 2.3 2 0 0 2 2 2 0 EF hand FtsK_SpoIIIE PF01580.18 ETS64793.1 - 0.078 12.3 0.5 2 7.7 0.1 2.8 3 0 0 3 3 3 0 FtsK/SpoIIIE family AAA_30 PF13604.6 ETS64793.1 - 0.083 12.6 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETS64793.1 - 0.083 13.3 0.0 5.9 7.3 0.0 2.4 2 0 0 2 2 2 0 RNA helicase SPARC_Ca_bdg PF10591.9 ETS64793.1 - 0.093 13.1 0.7 12 6.3 0.0 3.2 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region AAA PF00004.29 ETS64793.1 - 0.093 13.1 0.0 1.8 9.0 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 ETS64793.1 - 0.096 12.2 0.1 0.49 9.9 0.0 2.2 3 0 0 3 3 2 0 Ferrous iron transport protein B ABC_tran PF00005.27 ETS64793.1 - 0.12 12.8 0.0 24 5.4 0.0 2.3 2 0 0 2 2 2 0 ABC transporter DAP3 PF10236.9 ETS64793.1 - 0.13 11.4 0.1 0.38 9.9 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_7 PF12775.7 ETS64793.1 - 0.13 11.7 0.1 5.2 6.6 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 ETS64793.1 - 0.14 11.7 0.4 4.7 6.8 0.0 3.0 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 ETS64793.1 - 0.18 11.0 0.0 4.5 6.4 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 ETS64793.1 - 0.21 11.4 0.0 1.3 8.9 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 ETS64793.1 - 0.22 11.4 0.7 3.4 7.5 0.0 2.6 2 1 1 3 3 3 0 NTPase MCM PF00493.23 ETS64793.1 - 0.26 10.4 0.2 0.77 8.8 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain Septin PF00735.18 ETS64793.1 - 0.26 10.5 0.0 4.3 6.5 0.0 2.2 2 0 0 2 2 2 0 Septin NAD_binding_4 PF07993.12 ETS64794.1 - 6e-32 110.8 0.0 9.6e-32 110.2 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 ETS64794.1 - 2.8e-25 88.8 0.0 4.1e-25 88.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 ETS64794.1 - 4.8e-05 23.6 0.0 0.00012 22.4 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 ETS64794.1 - 0.042 13.8 3.4 0.3 11.0 2.7 2.6 2 1 0 2 2 2 0 KR domain Aminotran_5 PF00266.19 ETS64796.1 - 2.6e-31 108.9 0.0 3.7e-31 108.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V HAD_2 PF13419.6 ETS64797.1 - 1.3e-09 38.4 0.0 6.7e-09 36.1 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS64797.1 - 6.2e-05 23.0 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like zf-C3HC4 PF00097.25 ETS64798.1 - 5.1e-09 35.9 3.1 1.4e-08 34.5 3.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS64798.1 - 7.3e-08 32.3 3.3 7.3e-08 32.3 3.3 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETS64798.1 - 1.3e-07 31.8 3.1 5.2e-06 26.7 1.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETS64798.1 - 1.9e-07 30.8 5.2 9.1e-07 28.6 2.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS64798.1 - 5.9e-06 26.1 3.5 1e-05 25.4 3.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETS64798.1 - 0.00013 22.0 3.7 0.00013 22.0 3.7 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 ETS64798.1 - 0.0005 19.9 7.6 0.0026 17.6 7.6 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ETS64798.1 - 0.095 12.9 0.5 0.19 11.9 0.5 1.5 1 0 0 1 1 1 0 FYVE zinc finger zf-Nse PF11789.8 ETS64798.1 - 0.26 11.1 4.2 0.54 10.1 4.2 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 ETS64798.1 - 0.35 10.8 6.9 0.78 9.6 3.8 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Zwint PF15556.6 ETS64798.1 - 0.55 9.7 6.5 4.3 6.8 1.0 2.4 2 0 0 2 2 2 0 ZW10 interactor zf-rbx1 PF12678.7 ETS64798.1 - 0.78 10.1 4.8 2.5 8.5 4.8 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ETS64798.1 - 0.93 9.3 6.7 0.93 9.3 4.1 2.2 2 0 0 2 2 2 0 RING-like zinc finger Gly_transf_sug PF04488.15 ETS64799.1 - 4.5e-06 27.2 0.1 9.7e-06 26.1 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif SSF PF00474.17 ETS64800.1 - 2.1e-18 66.4 20.4 2.1e-18 66.4 20.4 1.7 2 0 0 2 2 2 1 Sodium:solute symporter family K_oxygenase PF13434.6 ETS64801.1 - 2.5e-10 40.0 0.0 4.9e-07 29.2 0.0 2.5 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 ETS64801.1 - 2e-06 27.3 0.1 0.019 14.2 0.3 3.1 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS64801.1 - 2.4e-05 24.3 0.8 0.46 10.5 0.0 4.0 4 0 0 4 4 4 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 ETS64801.1 - 0.00052 19.4 0.1 0.0024 17.2 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 ETS64801.1 - 0.0051 16.4 0.0 0.0051 16.4 0.0 2.8 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS64801.1 - 0.0053 16.0 0.0 0.2 10.9 0.0 3.0 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS64801.1 - 0.012 14.7 2.2 0.67 8.9 0.1 3.0 3 1 0 3 3 3 0 Lycopene cyclase protein DUF5632 PF18646.1 ETS64801.1 - 0.1 12.7 0.0 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5632) HI0933_like PF03486.14 ETS64801.1 - 0.15 10.7 0.1 1.8 7.2 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein RNA_pol_Rpb1_5 PF04998.17 ETS64803.1 - 1.2e-86 290.5 0.0 2.4e-86 289.5 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ETS64803.1 - 1.1e-50 172.1 0.0 2.5e-50 170.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ETS64803.1 - 4.9e-37 127.3 0.0 9.5e-37 126.4 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 ETS64803.1 - 3e-28 99.1 0.6 3.4e-22 79.2 0.0 4.4 5 0 0 5 5 5 3 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 ETS64803.1 - 1.9e-23 82.5 0.0 9.4e-23 80.2 0.0 2.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Med21 PF11221.8 ETS64803.1 - 0.99 9.7 4.7 11 6.3 2.4 3.4 3 0 0 3 3 3 0 Subunit 21 of Mediator complex Bac_rhodopsin PF01036.18 ETS64804.1 - 2.8e-05 23.8 0.0 3.8e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Bacteriorhodopsin-like protein O-ag_pol_Wzy PF14296.6 ETS64805.1 - 0.061 12.0 0.0 0.071 11.8 0.0 1.0 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy DUF4743 PF15916.5 ETS64806.1 - 8e-13 48.4 0.0 1.5e-10 41.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4743) NUDIX PF00293.28 ETS64806.1 - 9.3e-11 41.9 0.2 2.4e-10 40.6 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain Adaptin_N PF01602.20 ETS64806.1 - 0.023 13.3 0.2 0.36 9.3 0.1 2.4 2 0 0 2 2 2 0 Adaptin N terminal region Nipped-B_C PF12830.7 ETS64806.1 - 0.077 12.9 0.4 0.41 10.6 0.1 2.2 2 0 0 2 2 2 0 Sister chromatid cohesion C-terminus SPG48 PF14764.6 ETS64806.1 - 0.11 13.0 0.0 0.92 10.0 0.0 2.5 2 0 0 2 2 2 0 AP-5 complex subunit, vesicle trafficking HEAT_EZ PF13513.6 ETS64806.1 - 4.4 7.9 11.4 4.4 7.9 0.0 5.3 4 1 0 4 4 4 0 HEAT-like repeat MCM_bind PF09739.9 ETS64807.1 - 1.2e-83 281.5 0.0 4.4e-69 233.5 0.0 2.2 2 0 0 2 2 2 2 Mini-chromosome maintenance replisome factor Ala_racemase_N PF01168.20 ETS64807.1 - 2e-15 57.0 0.2 4.6e-14 52.6 0.0 2.9 2 1 0 2 2 2 1 Alanine racemase, N-terminal domain CS PF04969.16 ETS64808.1 - 1.1e-19 71.2 0.3 2.1e-19 70.3 0.3 1.5 1 0 0 1 1 1 1 CS domain Integrase_1 PF12835.7 ETS64808.1 - 0.0094 16.1 0.2 0.015 15.4 0.2 1.3 1 0 0 1 1 1 1 Integrase SieB PF14163.6 ETS64808.1 - 0.076 12.5 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Super-infection exclusion protein B Metal_resist PF13801.6 ETS64808.1 - 1.7 8.8 7.7 6.4 7.0 1.2 2.2 2 0 0 2 2 2 0 Heavy-metal resistance 6PF2K PF01591.18 ETS64809.1 - 2.8e-71 239.4 0.0 4.4e-71 238.7 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ETS64809.1 - 3.1e-33 115.1 0.0 1.3e-32 113.1 0.0 2.0 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ETS64809.1 - 1.1e-07 32.2 0.0 2.5e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ETS64809.1 - 0.027 13.9 0.2 0.092 12.2 0.0 1.9 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_17 PF13207.6 ETS64809.1 - 1 9.8 0.0 1 9.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain SelP_N PF04592.14 ETS64809.1 - 8.3 5.7 13.0 18 4.6 13.0 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RCC1 PF00415.18 ETS64810.1 - 3.5e-19 69.2 1.5 0.0015 19.1 0.0 5.9 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ETS64810.1 - 1e-17 64.3 0.0 3.2e-08 33.8 0.0 3.5 2 1 1 3 3 3 2 BTB/POZ domain Ank_4 PF13637.6 ETS64810.1 - 3.3e-07 30.7 0.2 1.2e-06 28.9 0.2 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RCC1_2 PF13540.6 ETS64810.1 - 3.4e-07 29.9 19.2 0.0016 18.2 0.0 6.5 7 0 0 7 7 7 3 Regulator of chromosome condensation (RCC1) repeat Ank_5 PF13857.6 ETS64810.1 - 1.9e-06 28.0 0.7 9.4e-05 22.6 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS64810.1 - 0.0006 20.3 0.0 0.0014 19.1 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETS64810.1 - 0.002 18.5 1.2 2.4 8.8 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 ETS64810.1 - 0.015 15.7 0.8 12 6.8 0.1 2.8 2 0 0 2 2 2 0 Ankyrin repeat Bromodomain PF00439.25 ETS64812.1 - 2.7e-52 174.8 0.3 5.1e-18 64.9 0.1 3.6 3 0 0 3 3 3 3 Bromodomain Peptidase_M1 PF01433.20 ETS64812.1 - 4.4e-05 23.2 0.0 8.7e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain HEAT_2 PF13646.6 ETS64812.1 - 0.00066 20.0 6.6 0.11 12.9 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats FBA_2 PF07735.17 ETS64812.1 - 0.2 11.8 0.0 0.57 10.3 0.0 1.7 1 0 0 1 1 1 0 F-box associated SKIP_SNW PF02731.15 ETS64813.1 - 1e-67 226.8 2.9 1e-67 226.8 2.9 1.9 2 0 0 2 2 2 1 SKIP/SNW domain Cwf_Cwc_15 PF04889.12 ETS64813.1 - 0.001 18.9 14.3 0.0021 17.9 14.3 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Dynamin_M PF01031.20 ETS64814.1 - 5.2e-103 344.2 0.0 1.2e-101 339.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 ETS64814.1 - 6.8e-54 182.4 0.0 1.2e-53 181.6 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ETS64814.1 - 3.2e-25 88.1 5.6 3.2e-25 88.1 5.6 2.1 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ETS64814.1 - 0.0004 20.4 0.1 0.0021 18.1 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase NTF2 PF02136.20 ETS64815.1 - 6.2e-35 120.4 0.3 6.9e-35 120.2 0.3 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4440 PF14534.6 ETS64815.1 - 0.0056 17.1 0.0 0.0065 16.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.6 ETS64815.1 - 0.049 13.8 0.0 0.051 13.7 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Imm58 PF15581.6 ETS64815.1 - 0.063 13.4 0.0 0.075 13.1 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 58 DUF3402 PF11882.8 ETS64816.1 - 2.4e-122 409.4 0.2 2.2e-121 406.2 0.0 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF3402) N1221 PF07923.13 ETS64816.1 - 3.5e-61 206.9 0.0 5.6e-61 206.3 0.0 1.2 1 0 0 1 1 1 1 N1221-like protein MFS_1 PF07690.16 ETS64817.1 - 1.5e-47 162.3 37.9 2.1e-47 161.8 37.9 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2613 PF11021.8 ETS64818.1 - 0.072 13.2 0.4 0.072 13.2 0.4 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) Antimicrobial11 PF08106.11 ETS64818.1 - 1 9.5 4.2 17 5.7 0.2 2.9 1 1 1 2 2 2 0 Formaecin family Sigma_reg_N PF13800.6 ETS64818.1 - 4.4 7.7 11.4 0.51 10.7 2.0 3.2 3 0 0 3 3 3 0 Sigma factor regulator N-terminal HK PF02110.15 ETS64819.1 - 2.1e-62 210.7 3.7 3.5e-60 203.4 3.7 2.2 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 ETS64819.1 - 1.8e-44 151.2 0.1 4.4e-44 150.0 0.1 1.7 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 ETS64819.1 - 6.6e-05 22.4 0.2 0.00012 21.5 0.2 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase HTH_8 PF02954.19 ETS64819.1 - 0.14 12.0 0.0 1.7 8.5 0.0 2.7 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family tRNA-synt_1e PF01406.19 ETS64820.1 - 1.1e-122 409.1 0.0 1.6e-122 408.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ETS64820.1 - 2.4e-09 36.5 0.5 5.5e-05 22.1 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ETS64820.1 - 0.00047 18.5 0.0 0.074 11.3 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 ETS64820.1 - 0.0018 18.7 1.9 0.0027 18.1 0.0 2.3 2 0 0 2 2 2 1 DALR domain tRNA-synt_1c PF00749.21 ETS64820.1 - 0.0053 15.7 1.0 0.014 14.3 0.0 2.0 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1f PF01921.18 ETS64820.1 - 0.074 12.0 0.0 3.1 6.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) Sec1 PF00995.23 ETS64821.1 - 6.6e-111 372.3 0.0 1e-110 371.7 0.0 1.3 1 1 0 1 1 1 1 Sec1 family Ribonuclease_T2 PF00445.18 ETS64822.1 - 1.2e-37 129.9 0.4 1.6e-37 129.5 0.4 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family GST_C_2 PF13410.6 ETS64823.1 - 1.7e-09 37.6 0.0 3.6e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ETS64823.1 - 0.00047 20.5 0.0 0.001 19.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETS64823.1 - 0.00099 19.3 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETS64823.1 - 0.029 14.6 0.0 0.074 13.3 0.0 1.7 1 1 1 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ETS64823.1 - 0.041 13.7 0.0 0.088 12.6 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Telomere_reg-2 PF10193.9 ETS64824.1 - 1.1e-26 93.4 0.0 4.7e-26 91.4 0.0 2.2 2 0 0 2 2 2 1 Telomere length regulation protein MCD_N PF17408.2 ETS64824.1 - 0.11 12.6 0.3 0.4 10.8 0.3 1.9 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase N-terminal domain PHD PF00628.29 ETS64825.1 - 1e-06 28.5 10.1 1.7e-06 27.8 10.1 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETS64825.1 - 0.00085 18.8 7.2 0.0017 17.9 7.2 1.5 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 ETS64825.1 - 0.012 15.6 4.2 0.029 14.4 4.2 1.6 1 0 0 1 1 1 0 CW-type Zinc Finger Tropomyosin PF00261.20 ETS64827.1 - 0.00065 19.2 9.4 0.00065 19.2 9.4 9.8 3 3 4 7 7 7 1 Tropomyosin Mto2_bdg PF12808.7 ETS64827.1 - 0.0037 17.5 11.0 0.0037 17.5 11.0 10.0 10 2 0 10 10 10 1 Micro-tubular organiser Mto1 C-term Mto2-binding region Leu_zip PF15294.6 ETS64827.1 - 0.0058 16.2 15.4 0.0058 16.2 15.4 8.1 3 2 5 8 8 8 2 Leucine zipper ATG16 PF08614.11 ETS64827.1 - 0.0089 16.3 34.4 0.0089 16.3 34.4 11.1 1 1 8 10 10 10 3 Autophagy protein 16 (ATG16) HMMR_N PF15905.5 ETS64827.1 - 0.35 10.3 151.9 0.6 9.5 19.1 7.0 3 2 3 6 6 6 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 ETS64827.1 - 0.48 9.3 155.2 0.019 13.9 16.3 8.5 3 2 7 10 10 10 0 Spc7 kinetochore protein AAA_13 PF13166.6 ETS64827.1 - 0.95 8.0 112.6 0.45 9.1 23.8 5.1 3 1 2 5 5 5 0 AAA domain Pox_A_type_inc PF04508.12 ETS64827.1 - 1.2 9.1 0.0 1.2 9.1 0.0 9.5 11 1 0 11 11 11 0 Viral A-type inclusion protein repeat LMSTEN PF07988.12 ETS64827.1 - 1.3 8.5 8.1 2.3 7.7 0.2 3.7 3 0 0 3 3 3 0 LMSTEN motif Fungal_trans PF04082.18 ETS64828.1 - 9.6e-08 31.4 2.0 5.3e-07 28.9 0.0 2.7 3 1 1 4 4 4 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ETS64828.1 - 9.8e-08 32.0 7.8 1.6e-07 31.4 7.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_M16_C PF05193.21 ETS64829.1 - 8e-45 153.1 0.0 1.2e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ETS64829.1 - 1.5e-42 145.1 0.0 3.6e-42 143.9 0.0 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) TRPM_tetra PF16519.5 ETS64829.1 - 0.74 10.0 3.0 9.1 6.5 0.2 2.7 2 0 0 2 2 2 0 Tetramerisation domain of TRPM SOG2 PF10428.9 ETS64829.1 - 8.8 5.4 25.1 0.82 8.8 2.4 2.2 2 0 0 2 2 2 0 RAM signalling pathway protein Hydrolase_4 PF12146.8 ETS64830.1 - 1.1e-29 103.4 0.2 3.4e-29 101.8 0.2 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS64830.1 - 8.1e-09 36.4 0.5 1.9e-08 35.2 0.5 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETS64830.1 - 1.6e-07 31.3 0.2 6.7e-05 22.7 0.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 ETS64830.1 - 0.0073 15.9 0.0 2.7 7.5 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Esterase PF00756.20 ETS64830.1 - 0.0098 15.6 0.0 0.13 11.9 0.0 2.2 2 0 0 2 2 2 1 Putative esterase MFS_1 PF07690.16 ETS64831.1 - 3.2e-37 128.3 52.7 2.1e-36 125.6 52.7 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64831.1 - 4.3e-14 52.2 7.4 4.3e-14 52.2 7.4 3.2 2 1 0 3 3 3 1 Sugar (and other) transporter DUF2516 PF10724.9 ETS64831.1 - 2.8 8.3 5.8 1 9.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2516) Asp PF00026.23 ETS64832.1 - 3.9e-70 236.8 0.2 4.9e-70 236.5 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS64832.1 - 2.9e-12 47.2 0.4 5.1e-05 23.6 0.1 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS64832.1 - 2e-05 25.1 0.9 0.026 15.2 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ETS64832.1 - 4.5e-05 23.9 0.1 0.012 16.2 0.0 3.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Syja_N PF02383.18 ETS64834.1 - 7.8e-74 248.8 0.0 1.1e-73 248.3 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 ETS64834.1 - 1.1e-10 41.5 0.0 2.3e-10 40.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family F-box-like PF12937.7 ETS64835.1 - 1.3e-11 44.2 2.2 1.3e-11 44.2 2.2 2.8 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ETS64835.1 - 1.1e-08 34.7 0.6 9.4e-08 31.8 0.2 2.6 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 ETS64835.1 - 0.026 14.4 0.0 0.062 13.2 0.0 1.7 1 0 0 1 1 1 0 F-box ATP_synt_H PF05493.13 ETS64836.1 - 1.8e-21 76.3 3.7 2.2e-21 76.1 3.7 1.1 1 0 0 1 1 1 1 ATP synthase subunit H NAD_binding_2 PF03446.15 ETS64837.1 - 5.1e-18 65.7 0.0 8.6e-18 65.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ETS64837.1 - 7.1e-11 42.4 0.0 1.3e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Shikimate_DH PF01488.20 ETS64837.1 - 1.1e-06 28.8 0.0 2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ETS64837.1 - 9.9e-05 22.9 0.0 0.00042 20.8 0.0 2.0 2 1 1 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent Rad21_Rec8_N PF04825.13 ETS64838.1 - 1.7e-38 131.1 0.2 3.5e-38 130.2 0.2 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ETS64838.1 - 1.8e-16 59.1 0.0 5.1e-16 57.7 0.0 1.8 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SIP1 PF04938.12 ETS64838.1 - 0.048 13.4 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) Cyclin_N PF00134.23 ETS64842.1 - 2.6e-44 150.0 0.6 7.9e-42 142.0 0.9 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETS64842.1 - 1.8e-26 92.5 0.0 1.8e-26 92.5 0.0 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain zf-MYND PF01753.18 ETS64843.1 - 4.9e-06 26.5 15.8 4.9e-06 26.5 15.8 2.2 2 0 0 2 2 2 1 MYND finger CLPTM1 PF05602.12 ETS64844.1 - 1.8e-110 369.9 0.0 7.6e-109 364.6 0.0 2.1 2 0 0 2 2 2 2 Cleft lip and palate transmembrane protein 1 (CLPTM1) PQ-loop PF04193.14 ETS64844.1 - 2.6e-05 23.9 0.7 0.00011 21.9 0.5 2.2 2 0 0 2 2 2 1 PQ loop repeat SecIII_SopE_N PF05364.14 ETS64844.1 - 0.075 13.1 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 Salmonella type III secretion SopE effector N-terminus MFS_1 PF07690.16 ETS64845.1 - 2.7e-27 95.6 33.0 2.9e-27 95.5 30.8 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64845.1 - 8.2e-11 41.4 4.8 8.2e-11 41.4 4.8 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter AMP-binding PF00501.28 ETS64847.1 - 2e-71 240.9 0.0 2.6e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETS64847.1 - 0.00078 20.4 0.2 0.0017 19.3 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PLU-1 PF08429.11 ETS64848.1 - 3.4e-88 296.1 1.3 3.6e-87 292.7 1.2 2.3 2 0 0 2 2 2 1 PLU-1-like protein JmjC PF02373.22 ETS64848.1 - 7.3e-43 145.6 0.4 1.5e-42 144.6 0.4 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase PHD PF00628.29 ETS64848.1 - 3.7e-26 90.8 37.5 8.8e-13 47.9 3.2 4.4 4 0 0 4 4 4 3 PHD-finger ARID PF01388.21 ETS64848.1 - 1.6e-18 67.1 0.1 5.3e-18 65.5 0.0 1.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 ETS64848.1 - 9e-14 51.1 1.0 1.7e-13 50.3 1.0 1.5 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 ETS64848.1 - 7e-11 42.4 0.1 7e-11 42.4 0.1 3.0 4 0 0 4 4 2 1 C5HC2 zinc finger zf-HC5HC2H PF13771.6 ETS64848.1 - 0.00074 19.7 10.3 1.1 9.6 0.2 3.5 3 0 0 3 3 3 3 PHD-like zinc-binding domain PHD_2 PF13831.6 ETS64848.1 - 0.0033 16.9 26.1 0.016 14.7 2.8 3.9 4 0 0 4 4 4 2 PHD-finger Fe-ADH_2 PF13685.6 ETS64848.1 - 0.017 14.8 0.2 0.039 13.6 0.2 1.5 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Zf_RING PF16744.5 ETS64848.1 - 0.046 13.8 0.3 0.046 13.8 0.3 3.8 3 0 0 3 3 3 0 KIAA1045 RING finger TusA PF01206.17 ETS64848.1 - 0.071 12.9 0.2 2.4 8.0 0.1 2.6 2 0 0 2 2 2 0 Sulfurtransferase TusA zf-HC5HC2H_2 PF13832.6 ETS64848.1 - 0.13 12.4 9.5 3.5 7.8 0.4 3.4 3 0 0 3 3 3 0 PHD-zinc-finger like domain C1_1 PF00130.22 ETS64848.1 - 0.35 10.8 23.4 0.67 9.9 1.3 4.2 4 0 0 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) E1-E2_ATPase PF00122.20 ETS64849.1 - 6.1e-41 139.9 1.2 3e-38 131.2 0.0 3.3 3 1 0 3 3 3 2 E1-E2 ATPase Hydrolase PF00702.26 ETS64849.1 - 1.7e-18 67.6 0.6 3.5e-18 66.6 0.6 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ETS64849.1 - 1.3e-10 40.8 0.0 2.7e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ETS64849.1 - 0.0018 18.1 0.3 0.0039 17.0 0.1 1.6 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase YrvL PF14184.6 ETS64849.1 - 0.0034 17.5 4.5 0.0034 17.5 4.5 2.4 2 0 0 2 2 2 1 Regulatory protein YrvL Cation_ATPase PF13246.6 ETS64849.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) RPA_C PF08784.11 ETS64851.1 - 4.5e-16 59.4 0.3 8.6e-16 58.5 0.3 1.5 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 ETS64851.1 - 1.8e-08 34.3 0.2 2.9e-08 33.6 0.2 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 ETS64851.1 - 0.044 13.6 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 MarR_2 PF12802.7 ETS64851.1 - 0.065 13.1 0.1 0.35 10.8 0.0 2.2 3 0 0 3 3 3 0 MarR family DUF1204 PF06721.11 ETS64851.1 - 0.065 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) FTA2 PF13095.6 ETS64851.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Het-C PF07217.11 ETS64852.1 - 2.4e-219 729.6 0.0 4.8e-219 728.6 0.0 1.5 1 1 0 1 1 1 1 Heterokaryon incompatibility protein Het-C 6PGD PF00393.19 ETS64853.1 - 4.7e-127 423.3 0.0 5.8e-127 423.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ETS64853.1 - 2.1e-52 177.5 0.0 3e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ETS64853.1 - 0.017 15.7 0.1 0.033 14.8 0.1 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_11 PF14833.6 ETS64853.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Ub-Mut7C PF14451.6 ETS64853.1 - 0.2 11.5 0.0 0.48 10.3 0.0 1.6 1 0 0 1 1 1 0 Mut7-C ubiquitin CoatB PF10389.9 ETS64853.1 - 0.23 11.3 1.8 0.88 9.5 0.2 2.3 2 0 0 2 2 2 0 Bacteriophage coat protein B Sterol-sensing PF12349.8 ETS64855.1 - 2.7e-48 163.7 10.8 4.7e-48 162.9 10.8 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ETS64855.1 - 3e-16 58.7 5.2 4.3e-16 58.2 5.2 1.1 1 0 0 1 1 1 1 Patched family ANAPC4_WD40 PF12894.7 ETS64855.1 - 0.00032 20.9 0.1 0.43 10.9 0.0 4.0 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETS64855.1 - 0.022 13.4 0.1 0.053 12.2 0.2 1.5 2 0 0 2 2 2 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETS64855.1 - 0.025 15.5 0.7 0.79 10.7 0.0 3.7 3 0 0 3 3 3 0 WD domain, G-beta repeat ADH_zinc_N PF00107.26 ETS64856.1 - 2.5e-08 34.0 0.0 5.4e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETS64856.1 - 3e-07 30.3 0.0 6.6e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 ETS64856.1 - 0.04 15.0 0.0 0.093 13.8 0.0 1.8 1 0 0 1 1 1 0 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ETS64856.1 - 0.053 13.4 0.1 0.13 12.2 0.1 1.6 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase UFD1 PF03152.14 ETS64858.1 - 2.9e-68 228.7 0.0 3.8e-68 228.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Cpn60_TCP1 PF00118.24 ETS64859.1 - 1.2e-147 492.5 17.4 2.1e-147 491.7 17.4 1.3 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Chitin_synth_2 PF03142.15 ETS64860.1 - 7.7e-293 971.9 0.0 9.6e-293 971.5 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 ETS64860.1 - 2.3e-11 44.0 1.2 7e-11 42.4 1.2 1.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ETS64860.1 - 2.7e-11 43.8 0.0 6.4e-11 42.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ETS64860.1 - 4.1e-05 23.1 0.0 0.0046 16.5 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ETS64860.1 - 0.0029 17.4 0.0 0.014 15.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 2 ABC_membrane PF00664.23 ETS64861.1 - 7.2e-79 265.3 21.5 4.9e-40 137.9 5.5 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETS64861.1 - 7.1e-51 172.3 0.1 2.6e-31 108.9 0.1 2.9 2 1 0 2 2 2 2 ABC transporter MTABC_N PF16185.5 ETS64861.1 - 1.4e-05 24.7 0.1 4.9e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 Mitochondrial ABC-transporter N-terminal five TM region MMR_HSR1 PF01926.23 ETS64861.1 - 3.1e-05 24.0 0.5 0.16 12.1 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase SMC_N PF02463.19 ETS64861.1 - 4.2e-05 23.1 0.1 1.1 8.6 0.0 3.9 2 2 1 4 4 4 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 ETS64861.1 - 0.00012 22.2 2.1 0.34 11.0 0.2 2.8 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_16 PF13191.6 ETS64861.1 - 0.001 19.5 6.0 0.069 13.5 0.5 3.3 2 1 1 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 ETS64861.1 - 0.0011 18.9 0.1 0.86 9.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ETS64861.1 - 0.0025 17.9 3.0 0.065 13.3 0.1 2.8 3 0 0 3 3 3 1 Dynamin family AAA_29 PF13555.6 ETS64861.1 - 0.0096 15.7 0.9 3.9 7.3 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain IstB_IS21 PF01695.17 ETS64861.1 - 0.018 14.8 0.1 7.9 6.2 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein MpPF26 PF07666.11 ETS64861.1 - 0.049 13.8 0.4 0.24 11.5 0.4 2.2 1 0 0 1 1 1 0 M penetrans paralogue family 26 T2SSE PF00437.20 ETS64861.1 - 0.097 11.7 0.2 1.6 7.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein UPF0093 PF03653.13 ETS64861.1 - 0.11 12.7 1.0 0.27 11.4 0.1 2.2 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0093) DUF815 PF05673.13 ETS64861.1 - 0.18 11.0 0.6 3.2 6.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Sre PF03125.18 ETS64861.1 - 0.36 9.9 4.0 0.37 9.9 0.2 2.7 3 1 1 4 4 4 0 C. elegans Sre G protein-coupled chemoreceptor CrgA PF06781.12 ETS64861.1 - 1.2 9.2 2.9 3.3 7.8 0.1 2.7 2 0 0 2 2 2 0 Cell division protein CrgA AAA_30 PF13604.6 ETS64861.1 - 2.4 7.8 4.4 18 4.9 0.8 3.0 2 1 0 2 2 2 0 AAA domain IMPDH PF00478.25 ETS64862.1 - 8.9e-132 439.3 0.0 1.9e-131 438.2 0.0 1.5 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Hat1_N PF10394.9 ETS64862.1 - 1.1e-43 149.3 0.0 1.7e-43 148.6 0.0 1.3 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus CBS PF00571.28 ETS64862.1 - 2.7e-16 59.8 0.1 6.4e-07 29.7 0.0 2.9 3 0 0 3 3 2 2 CBS domain NMO PF03060.15 ETS64862.1 - 1.2e-09 38.0 4.5 1e-07 31.7 3.2 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 ETS64862.1 - 1.8e-09 37.1 1.4 4.3e-09 35.9 1.4 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 ETS64862.1 - 5.9e-08 32.5 1.7 7.9e-07 28.8 2.6 2.3 2 1 0 2 2 2 1 Histidine biosynthesis protein Acetyltransf_1 PF00583.25 ETS64862.1 - 2.1e-05 24.7 0.0 5.5e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 ETS64862.1 - 2.6e-05 23.9 0.0 5.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 MOZ/SAS family ThiG PF05690.14 ETS64862.1 - 0.00057 19.3 1.7 0.001 18.4 1.7 1.4 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG Acetyltransf_10 PF13673.7 ETS64862.1 - 0.035 14.0 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF561 PF04481.12 ETS64862.1 - 0.043 13.0 0.5 0.26 10.4 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF561) G3P_antiterm PF04309.12 ETS64862.1 - 0.047 13.1 1.7 0.31 10.4 0.3 2.4 2 0 0 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Dus PF01207.17 ETS64862.1 - 5.4 6.0 6.7 0.61 9.1 0.1 2.3 3 0 0 3 3 3 0 Dihydrouridine synthase (Dus) Glu_synthase PF01645.17 ETS64862.1 - 5.8 5.9 8.2 1.1 8.3 4.0 1.9 2 0 0 2 2 2 0 Conserved region in glutamate synthase RRP7 PF12923.7 ETS64863.1 - 7.3e-27 93.9 1.7 1e-26 93.4 0.0 2.1 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 ETS64863.1 - 9e-12 45.1 0.0 1.6e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 ETS64863.1 - 1.2e-05 25.0 0.0 2.4e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PBP1_TM PF14812.6 ETS64863.1 - 0.13 12.6 3.5 0.31 11.4 3.5 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tim17 PF02466.19 ETS64864.1 - 4.9e-34 117.0 6.4 6e-34 116.8 6.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF543 PF04418.12 ETS64864.1 - 1.2 9.2 0.0 1.2 9.2 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF543) Nop PF01798.18 ETS64865.1 - 4.5e-86 288.0 0.1 9.6e-86 287.0 0.1 1.6 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ETS64865.1 - 1.1e-16 61.0 0.4 3.2e-16 59.5 0.4 1.9 1 0 0 1 1 1 1 NOP5NT (NUC127) domain RNA_polI_A34 PF08208.11 ETS64865.1 - 0.64 10.1 20.3 1.3 9.1 20.3 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 EMP24_GP25L PF01105.24 ETS64866.1 - 1.2e-47 162.2 0.0 1.7e-47 161.7 0.0 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 ETS64866.1 - 0.04 14.1 0.2 0.061 13.6 0.2 1.3 1 0 0 1 1 1 0 SdrD B-like domain Apocytochr_F_C PF01333.19 ETS64866.1 - 0.069 13.2 0.0 1.4 9.0 0.0 2.2 2 0 0 2 2 2 0 Apocytochrome F, C-terminal DUF4212 PF13937.6 ETS64866.1 - 0.14 12.5 0.5 0.95 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) Ran_BP1 PF00638.18 ETS64867.1 - 3.3e-51 172.7 1.0 4.8e-51 172.1 1.0 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 ETS64867.1 - 0.00028 20.8 0.9 0.0013 18.6 0.9 1.9 1 1 0 1 1 1 1 WH1 domain DUF1681 PF07933.14 ETS64867.1 - 0.00092 18.9 0.7 0.0012 18.5 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) VID27_PH PF17747.1 ETS64867.1 - 0.015 15.6 0.0 0.023 15.0 0.0 1.2 1 0 0 1 1 1 0 VID27 PH-like domain CK2S PF15011.6 ETS64867.1 - 0.049 13.5 0.2 0.078 12.9 0.2 1.3 1 0 0 1 1 1 0 Casein Kinase 2 substrate Tau95 PF09734.9 ETS64868.1 - 4.8e-34 118.2 0.0 9.3e-34 117.2 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 ETS64868.1 - 2.4e-21 76.2 0.0 4.2e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain Pol_alpha_B_N PF08418.10 ETS64869.1 - 2.2e-60 204.7 0.0 2.9e-60 204.3 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 ETS64869.1 - 3.8e-24 85.2 0.0 5.4e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B VPS13_mid_rpt PF16910.5 ETS64870.1 - 4.3e-91 304.5 9.5 2.4e-90 302.1 0.2 4.8 4 1 1 5 5 5 1 Repeating coiled region of VPS13 VPS13 PF16908.5 ETS64870.1 - 3.2e-83 279.1 0.7 3.3e-80 269.3 0.0 3.3 3 0 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal SHR-BD PF06650.12 ETS64870.1 - 2.2e-80 269.9 0.0 1.6e-77 260.6 0.0 3.1 2 1 1 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 ETS64870.1 - 6.9e-74 247.5 4.1 3.3e-69 232.2 0.2 2.7 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal Chorein_N PF12624.7 ETS64870.1 - 1.3e-38 131.7 0.2 4.7e-38 129.9 0.2 2.1 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 ETS64870.1 - 5.2e-09 36.3 0.0 8.4e-08 32.5 0.0 2.6 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Methyltransf_16 PF10294.9 ETS64871.1 - 2.6e-17 63.1 0.0 6.2e-17 61.9 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_24 PF13578.6 ETS64871.1 - 0.066 14.3 0.0 0.11 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Sec8_exocyst PF04048.14 ETS64872.1 - 8.6e-41 139.2 0.5 1.8e-40 138.1 0.5 1.6 1 0 0 1 1 1 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 ETS64872.1 - 0.00026 20.4 0.8 0.00046 19.6 0.8 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 ETS64872.1 - 0.0059 16.7 3.2 0.0088 16.1 0.8 2.4 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF2451 PF10474.9 ETS64872.1 - 0.0097 15.7 0.0 0.035 13.9 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) DUF1932 PF09130.11 ETS64873.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) RE_AccI PF09545.10 ETS64873.1 - 0.16 10.9 0.0 0.17 10.8 0.0 1.0 1 0 0 1 1 1 0 AccI restriction endonuclease Ribosomal_S5_C PF03719.15 ETS64874.1 - 6.4e-19 67.2 0.1 1.7e-18 65.8 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 ETS64874.1 - 3e-17 62.3 1.5 4.9e-17 61.7 1.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain SPX PF03105.19 ETS64874.1 - 0.5 10.2 5.4 0.63 9.9 5.4 1.2 1 0 0 1 1 1 0 SPX domain RRM_1 PF00076.22 ETS64875.1 - 5.9e-35 118.9 0.0 2.7e-18 65.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Complex1_LYR PF05347.15 ETS64877.1 - 0.0082 16.2 2.8 0.0082 16.2 0.5 2.2 2 0 0 2 2 2 1 Complex 1 protein (LYR family) EURL PF06937.11 ETS64877.1 - 0.034 13.6 1.6 0.053 12.9 1.6 1.2 1 0 0 1 1 1 0 EURL protein Rx_N PF18052.1 ETS64877.1 - 2.5 8.4 7.9 2.1 8.7 1.8 2.4 2 0 0 2 2 2 0 Rx N-terminal domain Cnn_1N PF07989.11 ETS64877.1 - 5.1 7.3 9.0 9.4 6.5 4.2 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 zf-C2H2 PF00096.26 ETS64878.1 - 0.0025 18.2 18.0 0.094 13.2 4.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS64878.1 - 0.033 15.0 2.8 0.033 15.0 2.8 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETS64878.1 - 0.047 14.0 8.3 0.12 12.7 0.7 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ETS64878.1 - 0.61 10.2 10.1 0.044 13.8 1.7 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger SR-25 PF10500.9 ETS64878.1 - 0.83 9.2 9.3 1.8 8.1 9.3 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PX PF00787.24 ETS64879.1 - 1.7e-16 60.2 0.3 6.7e-16 58.3 0.3 2.0 1 1 0 1 1 1 1 PX domain BAR_3_WASP_bdg PF10456.9 ETS64879.1 - 3.2e-08 33.3 0.1 4e-07 29.8 0.1 2.6 2 1 0 2 2 2 1 WASP-binding domain of Sorting nexin protein SH3_1 PF00018.28 ETS64879.1 - 0.0048 16.5 0.0 0.0097 15.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain Glyco_hydro_43 PF04616.14 ETS64880.1 - 1.6e-07 31.0 1.1 2.3e-07 30.4 1.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF5348 PF17295.2 ETS64880.1 - 0.11 12.4 0.1 0.72 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) Cnd1 PF12717.7 ETS64881.1 - 9.7e-57 191.5 1.7 1.5e-49 168.2 0.0 3.9 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 ETS64881.1 - 1.7e-44 151.6 0.0 1.7e-44 151.6 0.0 3.1 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 ETS64881.1 - 1.3e-08 34.4 4.5 3 8.3 0.0 7.5 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.6 ETS64881.1 - 1.1e-07 32.2 2.1 0.03 14.7 0.0 5.5 4 1 1 5 5 5 2 HEAT repeats Adaptin_N PF01602.20 ETS64881.1 - 5.6e-07 28.5 1.7 0.00074 18.2 0.7 3.4 3 1 0 3 3 3 2 Adaptin N terminal region Cnd3 PF12719.7 ETS64881.1 - 9.4e-07 28.3 3.4 2.7e-06 26.8 0.5 2.8 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 ETS64881.1 - 0.0087 16.2 0.1 18 5.6 0.0 3.9 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 CDC45 PF02724.14 ETS64881.1 - 0.0091 14.3 12.0 0.015 13.6 12.0 1.3 1 0 0 1 1 1 1 CDC45-like protein Cohesin_HEAT PF12765.7 ETS64881.1 - 0.04 14.2 0.0 4.8 7.6 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion PBP_like PF12727.7 ETS64881.1 - 0.055 12.6 1.7 0.15 11.2 1.7 1.7 1 0 0 1 1 1 0 PBP superfamily domain DUF913 PF06025.12 ETS64881.1 - 0.34 9.8 4.7 0.13 11.2 1.0 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SelK_SelG PF10961.8 ETS64881.1 - 0.38 11.4 1.6 3.4 8.4 0.6 2.9 2 0 0 2 2 2 0 Selenoprotein SelK_SelG HEAT_EZ PF13513.6 ETS64881.1 - 0.92 10.1 14.9 0.2 12.2 0.1 5.7 6 1 1 7 7 4 0 HEAT-like repeat YL1 PF05764.13 ETS64881.1 - 2.1 8.4 28.8 0.023 14.8 17.3 2.7 3 0 0 3 3 3 0 YL1 nuclear protein SDA1 PF05285.12 ETS64881.1 - 2.4 7.5 25.5 0.17 11.3 18.7 2.3 2 0 0 2 2 2 0 SDA1 Mpp10 PF04006.12 ETS64881.1 - 3 6.2 18.7 0.0057 15.2 8.3 1.6 2 0 0 2 2 2 0 Mpp10 protein DNA_pol_phi PF04931.13 ETS64881.1 - 4.2 5.4 25.0 27 2.7 0.0 2.4 2 0 0 2 2 2 0 DNA polymerase phi SAPS PF04499.15 ETS64881.1 - 7.9 5.1 7.9 1.8 7.2 3.9 1.9 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein TPR_14 PF13428.6 ETS64882.1 - 0.034 15.0 15.0 1.9 9.5 0.0 5.5 4 1 1 5 5 5 0 Tetratricopeptide repeat RNA_pol_I_TF PF04090.12 ETS64882.1 - 0.067 12.7 0.6 0.74 9.3 0.2 2.1 1 1 0 2 2 2 0 RNA polymerase I specific initiation factor Herpes_LMP1 PF05297.11 ETS64882.1 - 2.6 7.2 4.0 3.7 6.6 4.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Herpes_DNAp_acc PF04929.12 ETS64882.1 - 5.2 5.9 5.1 8.6 5.2 5.1 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CwfJ_C_1 PF04677.15 ETS64883.1 - 4.6e-14 52.3 0.0 8.5e-14 51.5 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 ETS64883.1 - 2.3e-10 40.1 2.4 4.2e-10 39.2 2.4 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ETS64883.1 - 0.00062 19.7 0.3 0.0013 18.7 0.3 1.6 1 0 0 1 1 1 1 Zinc knuckle CwfJ_C_2 PF04676.14 ETS64883.1 - 0.0029 18.4 0.0 0.0063 17.4 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 VMA21 PF09446.10 ETS64884.1 - 2.7e-11 43.4 10.2 4.5e-11 42.7 10.2 1.3 1 1 0 1 1 1 1 VMA21-like domain DUF4199 PF13858.6 ETS64884.1 - 0.36 11.2 2.9 0.43 11.0 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) ORC2 PF04084.14 ETS64885.1 - 1.6e-73 247.5 0.0 2.4e-73 247.0 0.0 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 PIN_4 PF13638.6 ETS64885.1 - 2e-22 79.8 0.0 4.4e-22 78.8 0.0 1.6 1 0 0 1 1 1 1 PIN domain Serglycin PF04360.12 ETS64885.1 - 0.13 12.2 2.4 0.17 11.8 1.0 1.8 2 0 0 2 2 2 0 Serglycin DUF1572 PF07609.11 ETS64890.1 - 0.017 14.9 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1572) DLH PF01738.18 ETS64892.1 - 8.7e-23 81.0 0.1 1.5e-22 80.3 0.1 1.4 1 1 0 1 1 1 1 Dienelactone hydrolase family Phosphodiest PF01663.22 ETS64893.1 - 3.3e-75 253.9 0.8 3.9e-75 253.7 0.8 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase SHNi-TPR PF10516.9 ETS64894.1 - 4.3e-11 42.1 0.3 1.1e-10 40.8 0.3 1.7 1 0 0 1 1 1 1 SHNi-TPR TPR_12 PF13424.6 ETS64894.1 - 0.0017 18.6 9.8 0.074 13.4 1.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat MSP1_C PF07462.11 ETS64894.1 - 0.0051 15.6 1.1 0.01 14.6 1.1 1.6 1 0 0 1 1 1 1 Merozoite surface protein 1 (MSP1) C-terminus TPR_2 PF07719.17 ETS64894.1 - 0.088 13.0 6.1 4 7.8 0.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat CHASE3 PF05227.13 ETS64894.1 - 1.1 9.2 13.9 1.5 8.7 0.8 3.4 2 1 1 3 3 3 0 CHASE3 domain TPR_1 PF00515.28 ETS64896.1 - 2.4e-23 80.9 2.1 6.5e-08 32.1 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETS64896.1 - 6.4e-22 75.9 10.2 2.7e-06 27.1 0.1 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETS64896.1 - 4.9e-16 57.5 2.8 0.0017 18.4 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETS64896.1 - 6.4e-15 54.6 5.2 0.00041 20.0 0.1 4.3 2 1 2 4 4 4 3 TPR repeat TPR_14 PF13428.6 ETS64896.1 - 2.4e-13 49.7 12.0 0.00063 20.4 0.1 6.7 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETS64896.1 - 7.3e-11 42.4 10.3 0.0031 18.0 0.2 4.3 3 2 1 4 4 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETS64896.1 - 2.1e-10 41.0 15.3 3.5e-06 27.5 0.1 5.7 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETS64896.1 - 4.9e-10 39.6 9.5 0.032 14.5 3.4 5.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETS64896.1 - 3.5e-09 36.4 4.9 0.0025 18.1 0.0 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS64896.1 - 5.9e-05 23.2 2.8 0.0085 16.3 0.7 2.7 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ETS64896.1 - 6.9e-05 23.2 10.0 2.7 8.8 0.2 6.0 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETS64896.1 - 0.0016 18.7 9.7 0.11 12.8 0.3 4.8 4 1 2 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETS64896.1 - 0.0027 17.8 4.4 0.52 10.5 0.2 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETS64896.1 - 0.003 17.5 7.9 0.45 10.7 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat LAL_C2 PF18603.1 ETS64896.1 - 0.049 13.8 0.2 6.3 7.0 0.0 3.1 3 0 0 3 3 3 0 L-amino acid ligase C-terminal domain 2 Wzy_C_2 PF11846.8 ETS64896.1 - 0.051 13.5 3.7 5.2 6.9 0.0 3.3 2 1 1 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal BTAD PF03704.17 ETS64896.1 - 0.052 14.0 11.9 0.36 11.3 2.3 3.9 4 0 0 4 4 4 0 Bacterial transcriptional activator domain Coatomer_E PF04733.14 ETS64896.1 - 0.16 11.3 1.6 4.3 6.7 0.1 2.8 3 1 0 3 3 3 0 Coatomer epsilon subunit TPR_10 PF13374.6 ETS64896.1 - 1.7 8.6 14.2 0.58 10.1 0.2 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat RNase_P_Rpp14 PF01900.19 ETS64897.1 - 1.6e-23 82.9 0.0 2.9e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Rpp14/Pop5 family IBR PF01485.21 ETS64898.1 - 3.6e-19 68.8 39.5 1.7e-12 47.4 4.4 4.3 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RWD PF05773.22 ETS64898.1 - 4.7e-10 39.8 2.2 4.4e-09 36.6 2.2 2.3 1 1 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 ETS64898.1 - 2.4e-05 24.6 4.4 2.4e-05 24.6 4.4 4.9 3 1 1 4 4 3 1 Ring finger domain zf-RING_11 PF17123.5 ETS64898.1 - 0.00012 21.8 4.7 0.00035 20.3 4.7 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETS64898.1 - 0.00013 21.9 4.6 0.00013 21.9 4.6 4.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETS64898.1 - 0.0004 20.2 6.5 0.0004 20.2 6.5 4.6 3 1 1 4 4 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS64898.1 - 0.0031 17.4 7.6 0.0031 17.4 7.6 4.1 4 0 0 4 4 4 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETS64898.1 - 0.0048 16.7 4.5 0.0048 16.7 4.5 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) DUF3025 PF11227.8 ETS64898.1 - 0.079 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3025) LDB19 PF13002.7 ETS64898.1 - 0.11 12.2 1.1 0.21 11.3 1.1 1.4 1 0 0 1 1 1 0 Arrestin_N terminal like Prok-RING_4 PF14447.6 ETS64898.1 - 1.4 8.8 33.6 0.42 10.5 5.1 4.3 3 1 1 4 4 4 0 Prokaryotic RING finger family 4 Nup192 PF11894.8 ETS64899.1 - 0 1215.3 0.0 0 1215.0 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 TFIIA PF03153.13 ETS64899.1 - 8.3 6.3 6.9 8.4 6.3 1.0 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Glyco_hydro_45 PF02015.16 ETS64900.1 - 1.3e-63 214.7 11.9 1.8e-63 214.3 11.9 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 45 Abhydrolase_3 PF07859.13 ETS64902.1 - 6.4e-36 124.2 0.1 1.2e-35 123.3 0.1 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ETS64902.1 - 6.4e-07 28.6 0.0 1.4e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Carboxylesterase family Say1_Mug180 PF10340.9 ETS64902.1 - 0.031 13.2 0.0 6.6 5.5 0.0 2.9 3 0 0 3 3 3 0 Steryl acetyl hydrolase GCP_N_terminal PF17681.1 ETS64903.1 - 2.5e-21 76.6 0.0 4.2e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ETS64903.1 - 4.2e-21 75.7 0.0 1.5e-11 44.4 0.0 2.6 2 1 0 2 2 2 2 Gamma tubulin complex component C-terminal Alg6_Alg8 PF03155.15 ETS64904.1 - 9.5e-120 400.8 16.8 8e-93 312.0 7.3 2.1 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family Ribosomal_L37ae PF01780.19 ETS64905.1 - 4.4e-42 142.1 8.6 4.9e-42 141.9 8.6 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 ETS64905.1 - 0.00099 19.2 1.1 0.0014 18.8 1.1 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-BED PF02892.15 ETS64905.1 - 0.008 16.2 3.2 0.76 9.9 0.1 2.2 1 1 1 2 2 2 2 BED zinc finger Zn_Tnp_IS1595 PF12760.7 ETS64905.1 - 0.016 15.1 2.5 0.027 14.4 2.5 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain C1_2 PF03107.16 ETS64905.1 - 0.36 11.2 3.3 2 8.8 3.3 1.9 1 1 0 1 1 1 0 C1 domain zf-H2C2_2 PF13465.6 ETS64905.1 - 0.88 10.1 6.2 2.6 8.6 1.3 2.2 1 1 1 2 2 2 0 Zinc-finger double domain Amidase PF01425.21 ETS64906.1 - 9.9e-71 239.0 1.4 4.2e-68 230.4 1.1 2.1 2 0 0 2 2 2 2 Amidase G-alpha PF00503.20 ETS64907.1 - 3.2e-98 329.1 1.2 3.8e-98 328.9 1.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETS64907.1 - 1.4e-06 27.9 0.2 0.027 14.0 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family FtsK_SpoIIIE PF01580.18 ETS64907.1 - 0.026 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 ETS64907.1 - 0.036 13.8 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3417 PF11897.8 ETS64907.1 - 0.097 13.1 0.2 0.66 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3417) MRP-L47 PF06984.13 ETS64908.1 - 5.1e-16 58.6 1.9 1.2e-15 57.4 1.9 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 ETS64908.1 - 0.00072 19.5 2.1 0.002 18.1 2.1 1.8 1 1 0 1 1 1 1 Ribosomal L29 protein Ribosomal_S24e PF01282.19 ETS64909.1 - 2e-32 110.9 0.0 3.9e-32 110.0 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S24e RRXRR PF14239.6 ETS64909.1 - 0.019 14.8 2.9 0.019 14.8 2.9 1.5 1 1 0 1 1 1 0 RRXRR protein HVSL PF09749.9 ETS64910.1 - 1.5e-32 113.0 0.0 1.7e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein EFG_II PF14492.6 ETS64910.1 - 0.16 12.0 0.0 0.49 10.5 0.0 1.8 1 0 0 1 1 1 0 Elongation Factor G, domain II Pkinase PF00069.25 ETS64911.1 - 1.1e-51 175.7 0.0 6.5e-51 173.2 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64911.1 - 3.8e-25 88.7 0.0 8.1e-25 87.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PFK PF00365.20 ETS64912.1 - 1.5e-185 615.1 0.5 4.3e-88 295.3 0.2 3.2 3 0 0 3 3 3 3 Phosphofructokinase PapJ PF14855.6 ETS64912.1 - 0.047 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone Cyclase PF04199.13 ETS64913.1 - 1.7e-14 54.2 0.1 8.7e-14 51.9 0.1 1.8 1 1 1 2 2 2 1 Putative cyclase RSN1_7TM PF02714.15 ETS64914.1 - 1.8e-73 247.3 16.3 3.6e-73 246.2 16.3 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ETS64914.1 - 4.4e-41 141.0 0.3 6.7e-41 140.4 0.3 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ETS64914.1 - 1.8e-37 128.5 4.3 1.8e-37 128.5 4.3 2.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 ETS64914.1 - 1.4e-09 37.9 0.0 3.8e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter TRAM_LAG1_CLN8 PF03798.16 ETS64916.1 - 1.3e-06 28.3 11.0 1.4e-06 28.2 10.0 1.5 1 1 0 1 1 1 1 TLC domain Aldedh PF00171.22 ETS64917.1 - 8.2e-180 598.2 0.1 9.2e-180 598.1 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETS64917.1 - 0.0003 20.3 0.0 0.0022 17.5 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) LuxC PF05893.14 ETS64917.1 - 0.049 12.7 0.0 0.079 12.0 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) GFA PF04828.14 ETS64918.1 - 1.8e-22 79.5 4.7 2.9e-22 78.8 4.7 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Auto_anti-p27 PF06677.12 ETS64918.1 - 0.035 14.3 0.1 0.035 14.3 0.1 2.5 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Rpr2 PF04032.16 ETS64918.1 - 0.25 11.6 0.2 0.25 11.6 0.2 1.9 1 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain NOB1_Zn_bind PF08772.11 ETS64918.1 - 1.4 9.1 6.8 0.91 9.7 0.3 2.4 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zf-NADH-PPase PF09297.11 ETS64918.1 - 2.4 7.9 9.8 0.45 10.2 0.3 2.7 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain adh_short_C2 PF13561.6 ETS64919.1 - 1.5e-55 188.3 0.8 1.8e-55 188.1 0.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS64919.1 - 4e-55 186.3 0.2 5e-55 186.0 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS64919.1 - 9.4e-16 58.2 0.6 1.3e-15 57.8 0.6 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETS64919.1 - 0.00016 21.2 0.6 0.00084 18.9 0.6 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family LytR_C PF13399.6 ETS64919.1 - 0.017 16.1 0.1 0.036 15.0 0.1 1.6 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator GDP_Man_Dehyd PF16363.5 ETS64919.1 - 0.024 14.0 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase HEM4 PF02602.15 ETS64919.1 - 0.054 12.8 0.1 0.096 12.0 0.1 1.3 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD Shikimate_DH PF01488.20 ETS64919.1 - 0.11 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3HCDH_N PF02737.18 ETS64919.1 - 0.13 12.1 0.1 0.23 11.3 0.1 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3425 PF11905.8 ETS64920.1 - 2.3e-18 66.4 0.3 4.4e-18 65.4 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) Sugar_tr PF00083.24 ETS64921.1 - 1.1e-108 364.0 20.5 1.4e-108 363.7 20.5 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS64921.1 - 3.8e-23 82.0 32.6 4.4e-23 81.8 26.1 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ETS64921.1 - 1.6e-05 23.5 0.4 3.6e-05 22.4 0.4 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_5 PF05631.14 ETS64921.1 - 0.0003 19.8 2.3 0.00064 18.7 2.3 1.5 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM zf-CCCH PF00642.24 ETS64922.1 - 5.4e-13 48.5 14.9 1.2e-06 28.3 2.8 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETS64922.1 - 0.0038 17.2 10.9 0.008 16.2 3.3 2.5 2 0 0 2 2 2 2 Zinc finger domain Phos_pyr_kin PF08543.12 ETS64922.1 - 0.2 11.0 0.0 0.31 10.4 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase zf-CCCH_3 PF15663.5 ETS64922.1 - 0.41 10.9 8.4 0.3 11.3 2.5 2.3 2 0 0 2 2 2 0 Zinc-finger containing family DEAD PF00270.29 ETS64923.1 - 1.4e-36 125.9 0.0 2.1e-36 125.3 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS64923.1 - 2.6e-29 101.8 0.0 9.2e-29 100.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS64923.1 - 0.00057 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Rxt3 PF08642.10 ETS64924.1 - 1.2e-20 74.6 4.3 1.7e-20 74.1 0.0 2.9 2 1 0 2 2 2 1 Histone deacetylation protein Rxt3 Macoilin PF09726.9 ETS64924.1 - 0.073 11.6 11.9 0.11 11.0 11.9 1.2 1 0 0 1 1 1 0 Macoilin family LCCL PF03815.19 ETS64924.1 - 0.089 12.9 0.0 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 LCCL domain ESCRT-II PF05871.12 ETS64925.1 - 1.9e-47 161.1 0.0 2.6e-47 160.6 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit UPRTase PF14681.6 ETS64926.1 - 5e-79 264.5 0.0 5.8e-79 264.3 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ETS64926.1 - 9.1e-05 22.0 0.0 0.00013 21.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain zf-C2H2_9 PF16293.5 ETS64928.1 - 0.0034 17.2 1.5 2.3 8.1 0.1 2.4 2 0 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-C2H2_4 PF13894.6 ETS64928.1 - 0.019 15.8 2.5 2.7 9.0 0.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ETS64928.1 - 0.022 15.1 0.0 4.7 7.6 0.0 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_4 PF13717.6 ETS64928.1 - 0.24 11.4 4.5 3.5 7.6 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2 PF00096.26 ETS64928.1 - 1.1 9.8 7.1 3.5 8.3 0.4 3.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type LSM PF01423.22 ETS64929.1 - 2e-17 62.6 0.0 3e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain MFS_1 PF07690.16 ETS64930.1 - 5.7e-28 97.9 25.1 5.7e-28 97.9 25.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS64930.1 - 6.2e-13 48.4 1.6 6.2e-13 48.4 1.6 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 ETS64930.1 - 0.0027 16.0 0.8 0.0065 14.8 0.8 1.6 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Hydrolase_4 PF12146.8 ETS64931.1 - 2.9e-12 46.4 0.0 3.6e-08 33.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETS64931.1 - 6.2e-12 45.7 0.0 3e-08 33.6 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold AXE1 PF05448.12 ETS64931.1 - 7.7e-10 37.9 0.1 1.8e-08 33.4 0.0 2.5 2 1 1 3 3 3 1 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 ETS64931.1 - 4.5e-09 37.2 0.1 6e-09 36.8 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ETS64931.1 - 5.7e-09 35.9 0.0 6.5e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETS64931.1 - 9.8e-09 35.0 0.0 2.1e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ETS64931.1 - 1.9e-08 34.2 0.0 2e-06 27.5 0.0 2.5 2 1 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 ETS64931.1 - 9.5e-06 25.7 0.0 2.6e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal PAF-AH_p_II PF03403.13 ETS64931.1 - 1.9e-05 23.3 0.2 0.11 10.9 0.1 2.1 1 1 1 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Abhydrolase_3 PF07859.13 ETS64931.1 - 0.0019 18.1 0.0 0.022 14.6 0.0 2.1 2 1 0 2 2 2 1 alpha/beta hydrolase fold DUF1100 PF06500.11 ETS64931.1 - 0.024 13.4 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1100) BRCT_2 PF16589.5 ETS64932.1 - 2e-21 76.2 0.0 0.0054 17.1 0.0 6.7 7 0 0 7 7 7 5 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ETS64932.1 - 1e-17 63.8 0.9 5.7e-13 48.6 0.1 5.0 5 0 0 5 5 5 2 twin BRCT domain BRCT PF00533.26 ETS64932.1 - 4e-16 59.2 0.0 1e-08 35.4 0.0 5.3 5 0 0 5 5 5 3 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 ETS64932.1 - 1.2e-10 41.2 0.0 9.6e-10 38.2 0.0 2.5 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 ETS64932.1 - 0.018 15.3 6.7 1 9.7 0.0 5.0 5 2 0 5 5 5 0 DNA ligase 3 BRCT domain SOG2 PF10428.9 ETS64932.1 - 0.76 8.9 9.2 1.3 8.2 9.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein RRM_1 PF00076.22 ETS64933.1 - 2.3e-13 49.8 0.0 3.7e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 ETS64933.1 - 7.9e-08 32.8 21.7 2.4e-07 31.2 11.4 2.4 2 0 0 2 2 2 2 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 ETS64933.1 - 0.00069 19.4 0.0 0.0014 18.5 0.0 1.4 1 0 0 1 1 1 1 Occluded RNA-recognition motif APH_6_hur PF04655.14 ETS64933.1 - 0.023 14.1 0.1 0.043 13.2 0.1 1.4 1 0 0 1 1 1 0 Aminoglycoside/hydroxyurea antibiotic resistance kinase RSN1_7TM PF02714.15 ETS64934.1 - 1.9e-74 250.4 30.1 3.2e-74 249.7 29.9 1.5 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ETS64934.1 - 1.4e-37 128.8 0.3 1.4e-37 128.8 0.3 2.1 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ETS64934.1 - 1.3e-34 119.9 0.0 2.1e-34 119.3 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF4024 PF13216.6 ETS64934.1 - 0.084 12.8 0.2 0.22 11.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4024) HSP20 PF00011.21 ETS64935.1 - 2.8e-17 62.7 0.4 2.2e-10 40.6 0.0 2.3 2 0 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ETS64935.1 - 4.8e-06 26.0 0.1 2.1e-05 24.0 0.1 2.0 1 1 0 1 1 1 1 HSP20-like domain found in ArsA GvpH PF05455.11 ETS64935.1 - 0.038 14.1 0.0 0.038 14.1 0.0 1.9 3 0 0 3 3 3 0 GvpH PI-PLC-C1 PF16670.5 ETS64936.1 - 0.00068 18.8 0.4 0.29 10.2 0.0 3.1 2 1 1 3 3 3 2 Phosphoinositide phospholipase C, Ca2+-dependent PI-PLC-X PF00388.19 ETS64936.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain BRO1 PF03097.18 ETS64937.1 - 1e-113 380.1 0.2 1.9e-113 379.2 0.0 1.6 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ETS64937.1 - 1.9e-76 257.2 2.1 3.5e-76 256.3 2.1 1.5 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF3294 PF07957.11 ETS64937.1 - 0.0021 17.8 0.1 0.0057 16.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) WGG PF10273.9 ETS64938.1 - 1.4e-20 73.7 0.0 2.8e-20 72.8 0.0 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 Macoilin PF09726.9 ETS64939.1 - 4.7 5.6 10.9 0.25 9.9 2.6 2.2 2 0 0 2 2 2 0 Macoilin family Sugar_tr PF00083.24 ETS64940.1 - 2.6e-83 280.4 19.9 3.1e-83 280.1 19.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS64940.1 - 3.7e-17 62.3 22.8 3.7e-17 62.3 22.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily TPR_4 PF07721.14 ETS64940.1 - 0.11 13.2 0.5 0.26 12.0 0.5 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat MFS_1_like PF12832.7 ETS64940.1 - 0.85 8.4 15.0 0.039 12.8 4.8 2.3 2 0 0 2 2 2 0 MFS_1 like family Phage_holin_2_4 PF16082.5 ETS64940.1 - 1.3 8.8 4.2 44 3.9 0.5 3.4 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like Melibiase PF02065.18 ETS64941.1 - 5.7e-117 390.5 0.0 8e-117 390.1 0.0 1.2 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 ETS64941.1 - 9.1e-38 130.2 0.0 1.3e-37 129.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 ETS64941.1 - 2e-08 34.6 0.0 4e-08 33.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain Voltage_CLC PF00654.20 ETS64942.1 - 1e-91 307.8 26.0 1e-91 307.8 26.0 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel DASH_Hsk3 PF08227.11 ETS64942.1 - 6.3e-11 42.5 0.8 1.3e-10 41.4 0.8 1.6 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like Ribophorin_II PF05817.14 ETS64942.1 - 3.6 6.0 3.9 5.8 5.3 3.9 1.2 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II Y_phosphatase2 PF03162.13 ETS64943.1 - 3.3e-49 166.6 0.0 3.8e-49 166.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ETS64943.1 - 0.0002 21.4 0.0 0.00099 19.1 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ETS64943.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.4 1 1 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETS64943.1 - 0.051 13.1 0.0 0.06 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF442 PF04273.13 ETS64943.1 - 0.21 11.7 0.0 0.31 11.2 0.0 1.3 1 0 0 1 1 1 0 Putative phosphatase (DUF442) XPG_N PF00752.17 ETS64944.1 - 2.1e-29 101.9 0.0 4.8e-29 100.8 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ETS64944.1 - 1e-25 89.9 0.0 3.2e-25 88.3 0.0 1.9 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ETS64944.1 - 0.00018 21.1 0.0 0.00072 19.1 0.0 2.0 1 1 0 1 1 1 1 XPG domain containing MFS_1 PF07690.16 ETS64945.1 - 3.3e-45 154.5 47.1 5.5e-43 147.2 49.2 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETS64945.1 - 4e-21 75.1 33.2 1.5e-20 73.1 33.5 1.6 1 1 1 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ETS64945.1 - 5.3e-11 42.0 30.4 2.2e-10 40.0 10.6 2.6 2 1 0 2 2 2 2 Sugar (and other) transporter DUF3530 PF12048.8 ETS64945.1 - 0.0088 15.5 0.1 0.016 14.7 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3530) DUF1180 PF06679.12 ETS64945.1 - 0.015 15.8 2.4 0.044 14.2 2.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) FAM176 PF14851.6 ETS64945.1 - 0.038 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 FAM176 family DUF5337 PF17272.2 ETS64945.1 - 0.26 11.1 8.2 0.14 12.0 3.7 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5337) NDUF_B12 PF08122.12 ETS64945.1 - 7.1 6.8 11.7 1.7 8.8 0.0 4.4 5 0 0 5 5 5 0 NADH-ubiquinone oxidoreductase B12 subunit family Cullin PF00888.22 ETS64946.1 - 1.6e-193 644.7 0.0 2.9e-193 643.9 0.0 1.4 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ETS64946.1 - 9.2e-26 89.7 1.1 2.5e-25 88.3 1.1 1.8 1 0 0 1 1 1 1 Cullin protein neddylation domain VPS28 PF03997.12 ETS64946.1 - 0.14 11.8 0.8 2 8.0 0.3 2.5 2 1 0 2 2 2 0 VPS28 protein DUF1180 PF06679.12 ETS64946.1 - 5.6 7.4 9.0 1.8 8.9 4.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) Adeno_PV PF03910.13 ETS64947.1 - 0.34 9.6 3.0 0.41 9.3 3.0 1.0 1 0 0 1 1 1 0 Adenovirus minor core protein PV Hydantoinase_A PF01968.18 ETS64948.1 - 3.4e-96 321.9 1.6 6.4e-96 321.0 1.6 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 ETS64948.1 - 7e-55 185.5 0.1 7.6e-53 178.8 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region VPS9 PF02204.18 ETS64950.1 - 3.5e-14 52.9 0.0 6.2e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain FUSC PF04632.12 ETS64951.1 - 0.044 12.3 1.2 0.11 11.0 1.2 1.6 1 0 0 1 1 1 0 Fusaric acid resistance protein family MFS_1 PF07690.16 ETS64952.1 - 1.7e-22 79.9 43.0 9.3e-18 64.3 15.6 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ETS64952.1 - 9.1e-06 25.2 1.3 9.1e-06 25.2 1.3 2.4 3 1 0 3 3 3 1 Uncharacterised MFS-type transporter YbfB DUF2370 PF10176.9 ETS64952.1 - 0.0042 16.8 1.1 0.0083 15.8 1.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) YL1 PF05764.13 ETS64952.1 - 0.061 13.4 0.2 0.087 12.9 0.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein MFS_1_like PF12832.7 ETS64952.1 - 0.1 11.4 16.2 1.1 8.0 8.4 2.9 2 1 0 2 2 2 0 MFS_1 like family Sugar_tr PF00083.24 ETS64952.1 - 0.85 8.4 17.0 0.024 13.5 6.0 2.1 2 0 0 2 2 2 0 Sugar (and other) transporter MFS_1 PF07690.16 ETS64953.1 - 1.5e-36 126.0 31.1 1.5e-36 126.0 31.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily F-box PF00646.33 ETS64954.1 - 0.0041 17.0 0.0 0.0089 15.9 0.0 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETS64954.1 - 0.0076 16.1 0.0 0.022 14.6 0.0 1.8 1 0 0 1 1 1 1 F-box-like Cwf_Cwc_15 PF04889.12 ETS64954.1 - 0.012 15.4 11.9 0.012 15.4 11.9 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETS64954.1 - 0.11 10.8 4.5 0.18 10.0 4.5 1.4 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETS64954.1 - 0.44 8.7 5.1 0.68 8.1 5.1 1.3 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 ETS64954.1 - 1.9 8.5 8.8 1.8 8.6 6.3 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 ETS64954.1 - 2.1 8.2 7.8 6.1 6.7 7.8 1.8 1 0 0 1 1 1 0 Sigma-70, non-essential region RRN3 PF05327.11 ETS64954.1 - 9.5 4.6 10.3 15 4.0 10.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.11 ETS64954.1 - 9.6 5.7 8.4 1.4 8.4 3.4 2.0 2 0 0 2 2 2 0 PPP4R2 EF-hand_1 PF00036.32 ETS64955.1 - 2.2e-41 136.3 12.2 6.3e-10 37.9 0.6 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETS64955.1 - 3.1e-35 120.5 2.4 7.6e-18 64.7 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETS64955.1 - 4.6e-31 106.4 11.6 9.3e-15 54.2 0.5 4.1 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ETS64955.1 - 8.2e-31 103.3 7.4 1.9e-09 36.7 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETS64955.1 - 3.3e-26 89.6 9.4 1.4e-06 27.5 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ETS64955.1 - 3.4e-15 56.1 0.1 3.4e-09 36.9 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETS64955.1 - 8.2e-10 38.6 1.3 6.6e-05 22.8 0.2 2.4 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETS64955.1 - 3.3e-08 33.8 0.0 0.0019 18.5 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 ETS64955.1 - 4.6e-06 26.6 0.0 0.057 13.4 0.0 3.1 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 ETS64955.1 - 2.7e-05 25.0 0.0 0.0077 17.1 0.0 2.1 1 1 1 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 ETS64955.1 - 0.00039 20.6 5.8 0.026 14.7 0.7 3.1 1 1 1 2 2 2 1 Dockerin type I domain EFhand_Ca_insen PF08726.10 ETS64955.1 - 0.00041 20.4 0.4 0.0021 18.1 0.1 2.2 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF3349 PF11829.8 ETS64955.1 - 0.00043 21.0 0.3 0.2 12.4 0.0 2.8 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF4497 PF14924.6 ETS64955.1 - 0.0019 18.6 0.0 1.8 9.1 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF4497) Caleosin PF05042.13 ETS64955.1 - 0.0032 17.4 0.7 0.85 9.5 0.0 3.3 1 1 3 4 4 4 1 Caleosin related protein DUF1103 PF06513.11 ETS64955.1 - 0.0037 16.9 2.6 0.0046 16.6 2.6 1.2 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) Poly_export PF02563.16 ETS64955.1 - 0.0072 16.5 0.1 0.92 9.8 0.0 3.0 1 1 2 3 3 3 1 Polysaccharide biosynthesis/export protein MotA_activ PF09114.10 ETS64955.1 - 0.0099 16.0 0.1 0.17 12.0 0.0 2.4 2 0 0 2 2 2 1 Transcription factor MotA, activation domain RNA_pol_Rpb4 PF03874.16 ETS64955.1 - 0.015 15.6 0.2 5.3 7.4 0.0 2.6 3 0 0 3 3 3 0 RNA polymerase Rpb4 TerB PF05099.13 ETS64955.1 - 0.021 14.8 0.4 1.7 8.6 0.1 2.4 1 1 1 2 2 2 0 Tellurite resistance protein TerB DUF5580 PF17743.1 ETS64955.1 - 0.036 12.6 0.0 0.038 12.5 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) dCache_2 PF08269.11 ETS64955.1 - 0.052 12.7 0.2 1.3 8.1 0.1 2.2 1 1 1 2 2 2 0 Cache domain SapB_1 PF05184.15 ETS64955.1 - 0.069 13.2 2.2 25 5.0 0.0 3.7 4 0 0 4 4 4 0 Saposin-like type B, region 1 SurA_N_2 PF13623.6 ETS64955.1 - 0.076 12.9 1.0 1.6 8.6 0.2 2.3 1 1 1 2 2 2 0 SurA N-terminal domain DUF1811 PF08838.10 ETS64955.1 - 0.095 13.0 0.0 24 5.2 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1811) Fe_hyd_lg_C PF02906.14 ETS64955.1 - 0.097 12.3 0.2 0.18 11.5 0.2 1.5 1 1 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain EF-hand_14 PF17959.1 ETS64955.1 - 0.1 12.9 0.4 23 5.4 0.0 2.7 2 1 1 3 3 2 0 EF-hand domain UcrQ PF02939.16 ETS64956.1 - 1.6e-31 108.1 1.8 2.4e-31 107.5 1.8 1.3 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 ETS64956.1 - 0.0087 16.4 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 Fe-ADH PF00465.19 ETS64957.1 - 4.9e-68 229.6 0.4 6.7e-68 229.1 0.4 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ETS64957.1 - 3.6e-15 56.4 0.0 8.7e-09 35.4 0.0 2.3 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Transposase_24 PF03004.14 ETS64957.1 - 0.0078 16.3 0.3 0.072 13.2 0.4 2.0 2 0 0 2 2 2 1 Plant transposase (Ptta/En/Spm family) LAGLIDADG_3 PF14528.6 ETS64957.1 - 0.11 12.9 0.0 0.28 11.5 0.0 1.7 1 0 0 1 1 1 0 LAGLIDADG-like domain zinc_ribbon_10 PF10058.9 ETS64958.1 - 4.7e-21 74.3 0.1 7.4e-21 73.6 0.1 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein Mu-like_Com PF10122.9 ETS64958.1 - 0.015 14.8 1.2 0.021 14.3 0.1 1.9 2 0 0 2 2 2 0 Mu-like prophage protein Com Zn_ribbon_SprT PF17283.2 ETS64958.1 - 0.92 9.5 3.5 2.5 8.1 0.9 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Histone PF00125.24 ETS64959.1 - 5e-49 166.0 8.0 3.6e-31 108.2 0.4 2.4 1 1 1 2 2 2 2 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ETS64959.1 - 3.2e-05 24.2 0.1 0.00011 22.5 0.0 1.8 2 0 0 2 2 2 1 CENP-S protein CENP-T_C PF15511.6 ETS64959.1 - 0.00038 20.5 0.1 0.0008 19.5 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ETS64959.1 - 0.0092 16.6 3.6 0.018 15.7 3.6 1.4 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ETS64959.1 - 0.013 15.8 0.1 0.024 14.9 0.1 1.4 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 ETS64959.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated RNA_pol_Rpc82 PF05645.13 ETS64959.1 - 0.15 11.8 0.3 0.27 10.9 0.0 1.5 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 WD40 PF00400.32 ETS64961.1 - 1e-24 86.3 7.4 9.7e-05 23.1 0.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS64961.1 - 1.7e-17 63.5 7.2 4e-07 30.3 0.4 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETS64961.1 - 1.6e-06 28.1 0.3 0.00015 21.7 0.1 2.4 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A HPP PF04982.13 ETS64962.1 - 1.2e-34 119.1 8.3 3e-34 117.8 8.3 1.7 1 0 0 1 1 1 1 HPP family DUF5357 PF17310.2 ETS64962.1 - 0.0043 15.7 0.5 0.0072 14.9 0.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5357) YL1_C PF08265.11 ETS64962.1 - 0.026 14.3 0.2 0.061 13.1 0.1 1.7 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain Nucleos_tra2_N PF01773.20 ETS64962.1 - 4.3 8.0 5.7 0.35 11.5 0.6 1.9 2 0 0 2 2 2 0 Na+ dependent nucleoside transporter N-terminus Fis1_TPR_C PF14853.6 ETS64963.1 - 5.6e-25 87.2 0.6 8.8e-25 86.5 0.6 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 ETS64963.1 - 4.8e-16 58.1 0.0 9.4e-16 57.2 0.0 1.5 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 ETS64963.1 - 0.00034 20.5 0.2 0.00082 19.3 0.2 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETS64963.1 - 0.071 13.8 0.0 0.25 12.1 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat COPI_C PF06957.11 ETS64963.1 - 0.13 11.0 0.0 0.26 10.0 0.0 1.4 2 0 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus PX PF00787.24 ETS64964.1 - 1.7e-21 76.3 0.4 3.2e-21 75.4 0.4 1.4 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 ETS64964.1 - 0.001 18.7 0.3 7.6 6.0 0.0 3.1 3 0 0 3 3 3 3 Vps5 C terminal like Clathrin PF00637.20 ETS64965.1 - 1.7e-208 682.9 28.2 4.8e-33 114.0 0.0 7.9 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_propel PF01394.20 ETS64965.1 - 4.3e-37 124.6 1.4 3.7e-08 33.3 0.1 6.7 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin_H_link PF13838.6 ETS64965.1 - 3e-33 113.6 0.1 3.5e-32 110.1 0.1 2.9 2 0 0 2 2 2 1 Clathrin-H-link Clathrin-link PF09268.10 ETS64965.1 - 7.5e-12 44.4 0.2 2.1e-11 43.0 0.2 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker TPR_14 PF13428.6 ETS64965.1 - 0.00031 21.3 6.5 23 6.2 0.0 8.9 9 0 0 9 9 9 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 ETS64965.1 - 0.0022 17.1 4.4 0.16 11.0 0.0 4.7 5 0 0 5 5 5 1 Coatomer WD associated region Vps39_1 PF10366.9 ETS64965.1 - 0.0047 17.2 3.9 13 6.1 0.0 5.1 3 2 0 3 3 3 2 Vacuolar sorting protein 39 domain 1 TPR_2 PF07719.17 ETS64965.1 - 0.018 15.1 6.4 43 4.6 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETS64965.1 - 0.022 14.6 3.0 15 5.6 0.2 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETS64965.1 - 3.8 7.8 8.4 58 4.1 0.1 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA PF00004.29 ETS64966.1 - 2.2e-43 147.8 0.0 3.7e-43 147.1 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETS64966.1 - 1.1e-10 41.2 0.1 2.2e-10 40.1 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ETS64966.1 - 7.2e-10 38.7 0.1 1.5e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 ETS64966.1 - 4.7e-07 30.4 0.0 0.00014 22.3 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ETS64966.1 - 6e-07 29.5 0.1 1.3e-05 25.2 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETS64966.1 - 8e-07 29.3 0.0 6e-06 26.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ETS64966.1 - 8e-06 25.7 0.0 1.8e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETS64966.1 - 0.00017 21.8 0.1 0.0048 17.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 ETS64966.1 - 0.00071 20.1 0.1 0.0063 17.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain DUF815 PF05673.13 ETS64966.1 - 0.00076 18.7 0.0 0.0018 17.5 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ETS64966.1 - 0.0011 18.6 0.0 0.0024 17.4 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 ETS64966.1 - 0.0026 17.5 0.2 0.017 14.8 0.0 2.4 3 0 0 3 3 3 1 AAA domain Mg_chelatase PF01078.21 ETS64966.1 - 0.0029 17.0 0.0 0.0059 16.0 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ETS64966.1 - 0.0039 16.5 0.0 0.0076 15.5 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 ETS64966.1 - 0.0058 17.0 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TsaE PF02367.17 ETS64966.1 - 0.0059 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 ETS64966.1 - 0.0059 16.6 0.0 0.015 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETS64966.1 - 0.0077 16.0 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 ETS64966.1 - 0.0078 16.4 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 ETS64966.1 - 0.0085 15.8 0.0 0.029 14.1 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain YkyA PF10368.9 ETS64966.1 - 0.013 15.2 0.7 0.03 14.0 0.7 1.5 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein AAA_3 PF07726.11 ETS64966.1 - 0.014 15.2 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETS64966.1 - 0.03 14.1 0.0 0.068 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETS64966.1 - 0.037 13.9 0.0 0.093 12.6 0.0 1.7 1 0 0 1 1 1 0 NACHT domain ATPase PF06745.13 ETS64966.1 - 0.048 13.0 0.0 0.17 11.2 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.6 ETS64966.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETS64966.1 - 0.061 12.8 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Parvo_NS1 PF01057.17 ETS64966.1 - 0.072 12.2 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.12 ETS64966.1 - 0.1 12.5 0.0 0.29 10.9 0.0 1.8 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Prot_ATP_OB_N PF17758.1 ETS64966.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Proteasomal ATPase OB N-terminal domain AAA_11 PF13086.6 ETS64966.1 - 0.11 12.2 0.3 0.35 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETS64966.1 - 0.15 11.6 0.1 0.35 10.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETS64966.1 - 0.2 12.1 2.5 28 5.1 2.2 2.5 2 0 0 2 2 2 0 AAA domain TPR_1 PF00515.28 ETS64966.1 - 8.8 6.3 6.8 0.74 9.7 0.9 2.3 3 0 0 3 3 2 0 Tetratricopeptide repeat GPI-anchored PF10342.9 ETS64967.1 - 1.7e-08 35.1 0.2 2.7e-08 34.4 0.2 1.4 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Big_7 PF17957.1 ETS64967.1 - 0.00019 22.1 0.1 0.00042 21.0 0.1 1.6 1 0 0 1 1 1 1 Bacterial Ig domain PH PF00169.29 ETS64968.1 - 0.0052 17.3 0.2 6.2 7.4 0.0 2.9 3 0 0 3 3 3 2 PH domain PH_9 PF15410.6 ETS64968.1 - 0.12 12.8 0.1 0.66 10.4 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Methyltransf_16 PF10294.9 ETS64969.1 - 3.5e-16 59.4 0.0 1.5e-13 50.9 0.0 2.1 1 1 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ETS64969.1 - 0.00053 19.9 0.0 0.00086 19.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Glyco_hydro_63 PF03200.16 ETS64970.1 - 2.9e-08 32.9 5.5 4.5e-06 25.7 0.1 4.5 4 1 0 4 4 4 2 Glycosyl hydrolase family 63 C-terminal domain Pro_isomerase PF00160.21 ETS64971.1 - 6.9e-34 117.4 0.0 1.3e-33 116.6 0.0 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF4604 PF15377.6 ETS64971.1 - 0.0001 22.8 0.3 0.0001 22.8 0.3 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4604) RNA_pol_Rbc25 PF08292.12 ETS64971.1 - 1.2 9.4 3.7 0.31 11.3 0.2 1.8 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 NUDIX PF00293.28 ETS64972.1 - 1.4e-09 38.0 0.0 2.3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain FAD_binding_3 PF01494.19 ETS64972.1 - 0.071 12.4 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain RNA_pol_Rpb6 PF01192.22 ETS64972.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb6 RRM_1 PF00076.22 ETS64973.1 - 6.3e-15 54.7 0.1 1.2e-14 53.9 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETS64973.1 - 0.007 16.0 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ETS64973.1 - 0.14 12.2 0.1 0.34 10.9 0.1 1.7 1 0 0 1 1 1 0 RL domain Ndc1_Nup PF09531.10 ETS64973.1 - 6.4 5.3 6.7 8.5 4.9 6.7 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4813 PF16072.5 ETS64973.1 - 6.9 6.2 33.6 9.7 5.8 33.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) CS PF04969.16 ETS64974.1 - 7.2e-05 23.7 0.0 0.00013 22.9 0.0 1.4 1 0 0 1 1 1 1 CS domain ProQ PF04352.13 ETS64974.1 - 0.14 12.0 0.1 0.2 11.6 0.1 1.2 1 0 0 1 1 1 0 ProQ/FINO family DAGAT PF03982.13 ETS64975.1 - 1.2e-104 349.4 0.0 1.6e-104 349.0 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase DAO PF01266.24 ETS64976.1 - 1.7e-33 116.7 0.8 2.5e-33 116.1 0.8 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETS64976.1 - 4.4e-11 42.5 5.2 9.4e-07 28.2 0.1 3.0 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_2 PF07992.14 ETS64976.1 - 7.6e-09 35.2 0.2 3.3e-07 29.8 0.2 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS64976.1 - 8.7e-06 25.9 0.2 5.3e-05 23.4 0.1 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 ETS64976.1 - 1.2e-05 24.6 0.2 0.027 13.5 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A HI0933_like PF03486.14 ETS64976.1 - 2.9e-05 23.0 0.2 0.082 11.6 0.0 2.4 2 0 0 2 2 2 2 HI0933-like protein NAD_binding_9 PF13454.6 ETS64976.1 - 0.00031 20.8 0.9 0.11 12.5 0.1 2.6 2 1 0 2 2 2 2 FAD-NAD(P)-binding 3HCDH_N PF02737.18 ETS64976.1 - 0.00036 20.5 0.0 0.00085 19.2 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox PF00070.27 ETS64976.1 - 0.00068 20.1 0.0 0.41 11.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETS64976.1 - 0.00089 18.6 0.1 0.0035 16.7 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Amino_oxidase PF01593.24 ETS64976.1 - 0.015 14.6 0.1 0.091 12.0 0.0 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 ETS64976.1 - 0.019 14.2 0.1 0.031 13.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 ETS64976.1 - 0.026 13.6 0.4 0.42 9.6 0.1 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 ETS64976.1 - 0.029 13.2 0.7 0.08 11.8 0.0 1.9 2 0 0 2 2 2 0 Tryptophan halogenase NAD_binding_2 PF03446.15 ETS64976.1 - 0.035 14.3 0.0 0.064 13.4 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Antirestrict PF03230.13 ETS64976.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Antirestriction protein TrkA_N PF02254.18 ETS64976.1 - 0.13 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Shikimate_DH PF01488.20 ETS64976.1 - 0.14 12.2 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDI PF00996.18 ETS64976.1 - 0.26 9.8 0.0 15 4.0 0.0 2.2 2 0 0 2 2 2 0 GDP dissociation inhibitor DUF1115 PF06544.12 ETS64977.1 - 0.0011 19.1 0.0 0.0054 16.8 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1115) ETC_C1_NDUFA5 PF04716.14 ETS64978.1 - 4.4e-19 68.1 5.3 9.1e-19 67.0 5.3 1.5 1 1 0 1 1 1 1 ETC complex I subunit conserved region WW PF00397.26 ETS64979.1 - 1e-08 35.1 3.1 1.9e-08 34.3 3.1 1.5 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 ETS64979.1 - 5.3 7.0 41.0 0.14 12.2 18.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Pkinase PF00069.25 ETS64980.1 - 4.2e-66 223.0 0.0 9.2e-66 221.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS64980.1 - 9.3e-34 116.9 0.0 1.5e-33 116.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase HIG_1_N PF04588.13 ETS64980.1 - 6.9e-06 26.2 0.6 2e-05 24.7 0.6 1.8 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Fungal_KA1 PF16797.5 ETS64980.1 - 0.00061 19.5 0.1 0.0033 17.1 0.0 2.2 2 0 0 2 2 2 1 Fungal kinase associated-1 domain APH PF01636.23 ETS64980.1 - 0.0016 18.4 0.0 0.01 15.8 0.0 2.3 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETS64980.1 - 0.0076 15.6 0.0 0.015 14.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETS64980.1 - 0.0091 15.3 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 ETS64980.1 - 0.058 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Methyltransf_10 PF05971.12 ETS64982.1 - 7.3e-41 140.4 0.3 1.5e-39 136.2 0.3 2.2 1 1 0 1 1 1 1 RNA methyltransferase CENP-O PF09496.10 ETS64982.1 - 1.3e-35 123.4 0.0 2.1e-35 122.7 0.0 1.3 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component HALZ PF02183.18 ETS64982.1 - 0.028 14.6 2.9 2.8 8.2 0.5 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper ABC_membrane_2 PF06472.15 ETS64984.1 - 7.4e-93 310.8 2.4 7.4e-93 310.8 2.4 1.6 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ETS64984.1 - 6.3e-16 59.1 0.0 2e-15 57.5 0.0 1.9 2 0 0 2 2 2 1 ABC transporter RuvB_N PF05496.12 ETS64984.1 - 0.0034 17.1 0.0 0.0083 15.9 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETS64984.1 - 0.0056 17.1 0.3 0.018 15.4 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 ETS64984.1 - 0.0076 16.7 0.0 0.016 15.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ETS64984.1 - 0.028 14.2 0.0 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ETS64984.1 - 0.031 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 ETS64984.1 - 0.055 14.0 0.6 0.13 12.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.8 ETS64984.1 - 0.093 10.2 0.0 0.15 9.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Sigma54_activat PF00158.26 ETS64984.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain SMC_N PF02463.19 ETS64984.1 - 0.15 11.4 0.0 10 5.5 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_7 PF12775.7 ETS64984.1 - 0.16 11.4 0.0 0.32 10.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Peptidase_S10 PF00450.22 ETS64987.1 - 1.8e-96 324.1 4.7 3.2e-96 323.3 4.7 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase Ribosomal_L33 PF00471.20 ETS64987.1 - 3.1e-11 43.5 0.0 1.1e-10 41.8 0.0 2.0 1 0 0 1 1 1 1 Ribosomal protein L33 Ran_BP1 PF00638.18 ETS64989.1 - 3.1e-22 79.1 0.1 6.4e-22 78.1 0.1 1.5 1 0 0 1 1 1 1 RanBP1 domain vATP-synt_E PF01991.18 ETS64990.1 - 2.3e-61 206.7 13.8 2.7e-61 206.5 13.8 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit eIF3g PF12353.8 ETS64991.1 - 5.9e-44 149.5 4.8 1e-43 148.7 4.8 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 ETS64991.1 - 4.2e-19 68.1 0.0 7.3e-19 67.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETS64991.1 - 0.055 13.5 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Ribonucleas_3_3 PF14622.6 ETS64992.1 - 2.2e-28 98.9 0.0 3e-28 98.5 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ETS64992.1 - 0.0002 21.9 0.0 0.0004 21.0 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III domain NUDIX_4 PF14815.6 ETS64993.1 - 1.1e-19 70.4 0.0 2.3e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 ETS64993.1 - 1.7e-18 67.0 0.0 3.7e-18 65.9 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ETS64993.1 - 2.5e-07 30.2 0.1 8.7e-07 28.5 0.1 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ETS64993.1 - 0.0092 16.3 8.9 0.027 14.8 8.9 1.9 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III Whib PF02467.16 ETS64993.1 - 0.11 13.2 2.9 0.55 10.9 1.2 2.5 2 0 0 2 2 2 0 Transcription factor WhiB NDUF_B8 PF05821.11 ETS64995.1 - 1.3e-07 31.6 0.1 3.5e-07 30.3 0.1 1.6 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) ERbeta_N PF12497.8 ETS64995.1 - 0.09 12.6 1.8 0.11 12.2 0.8 1.6 1 1 0 1 1 1 0 Estrogen receptor beta ELO PF01151.18 ETS64997.1 - 4.5e-59 200.0 19.0 5.8e-59 199.6 19.0 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Cpn60_TCP1 PF00118.24 ETS64998.1 - 4.4e-156 520.3 1.5 5e-156 520.2 1.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF448 PF04296.13 ETS64999.1 - 0.011 15.6 0.1 0.15 12.0 0.1 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF448) Fes1 PF08609.10 ETS65000.1 - 2.2e-23 83.0 0.5 8.4e-23 81.1 0.5 2.1 1 0 0 1 1 1 1 Nucleotide exchange factor Fes1 HEAT_2 PF13646.6 ETS65000.1 - 1.1e-06 28.9 1.8 1.8e-05 25.0 0.5 2.6 1 1 1 2 2 2 2 HEAT repeats HEAT PF02985.22 ETS65000.1 - 5.6e-06 26.2 0.2 0.4 11.1 0.0 4.2 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ETS65000.1 - 0.00012 22.5 2.8 0.0002 21.8 0.2 2.9 3 0 0 3 3 3 1 HEAT-like repeat Adaptin_N PF01602.20 ETS65000.1 - 0.00072 18.2 0.1 0.0019 16.9 0.1 1.6 1 1 1 2 2 2 1 Adaptin N terminal region Arm PF00514.23 ETS65000.1 - 0.0012 18.8 0.2 0.92 9.7 0.0 3.5 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 ETS65000.1 - 0.0063 16.6 0.5 2.3 8.4 0.1 2.4 1 1 1 2 2 2 2 V-ATPase subunit H DUF5578 PF17741.1 ETS65000.1 - 0.034 13.6 0.1 0.057 12.8 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5578) zf-RING_2 PF13639.6 ETS65001.1 - 7.1e-12 45.5 7.8 1.4e-11 44.5 7.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETS65001.1 - 2.9e-11 43.5 6.2 7.5e-11 42.2 6.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETS65001.1 - 2.8e-08 33.5 8.1 5.6e-08 32.5 8.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS65001.1 - 5.4e-08 32.6 7.0 1e-07 31.7 7.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETS65001.1 - 4.1e-07 30.0 3.3 9.1e-07 28.9 3.3 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ETS65001.1 - 4.1e-06 26.7 3.2 1.1e-05 25.4 3.2 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETS65001.1 - 4.6e-05 23.2 4.1 8.9e-05 22.3 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS65001.1 - 9.7e-05 22.3 5.4 0.00018 21.4 5.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETS65001.1 - 0.00077 19.1 5.9 0.0015 18.3 5.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger Zn_ribbon_17 PF17120.5 ETS65001.1 - 0.032 13.8 6.0 0.074 12.7 6.0 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_5 PF17121.5 ETS65001.1 - 0.095 12.6 4.5 0.29 11.0 4.6 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 ETS65001.1 - 0.13 12.4 6.1 0.32 11.1 6.1 1.7 1 0 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 ETS65001.1 - 0.15 11.9 4.6 0.37 10.6 4.7 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 ETS65001.1 - 0.16 11.9 5.6 0.32 10.9 5.6 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 ETS65001.1 - 0.19 11.9 4.9 0.18 12.0 3.0 2.0 2 0 0 2 2 2 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 ETS65001.1 - 0.33 11.1 3.9 0.7 10.1 3.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETS65001.1 - 0.42 10.5 8.7 15 5.6 9.1 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 ETS65001.1 - 0.65 10.4 7.1 1.7 9.0 7.1 1.8 1 0 0 1 1 1 0 RING-like domain Zf_RING PF16744.5 ETS65001.1 - 0.88 9.7 3.1 2.2 8.5 3.1 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zinc_ribbon_16 PF17034.5 ETS65001.1 - 2.3 8.5 7.0 6.2 7.1 7.0 1.7 1 1 0 1 1 1 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 ETS65001.1 - 3.3 7.8 7.4 1.7 8.7 3.1 2.4 2 0 0 2 2 2 0 Zinc-finger PRP3 PF08572.10 ETS65003.1 - 2.4e-63 213.8 1.3 2.4e-63 213.8 1.3 1.9 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 ETS65003.1 - 1.2e-37 129.2 0.4 2.9e-37 128.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1115) Phage_Nu1 PF07471.12 ETS65003.1 - 6.1 6.6 7.7 0.21 11.4 1.0 2.0 2 0 0 2 2 2 0 Phage DNA packaging protein Nu1 DUF4407 PF14362.6 ETS65003.1 - 6.5 6.0 16.0 0.78 9.0 4.8 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) PAPS_reduct PF01507.19 ETS65004.1 - 7.6e-20 71.7 0.1 3.6e-14 53.2 0.0 3.0 2 1 0 2 2 2 2 Phosphoadenosine phosphosulfate reductase family Utp14 PF04615.13 ETS65005.1 - 0.0015 17.2 7.0 0.0022 16.7 7.0 1.2 1 0 0 1 1 1 1 Utp14 protein Coilin_N PF15862.5 ETS65005.1 - 0.011 15.5 0.1 0.011 15.5 0.1 2.6 2 0 0 2 2 2 0 Coilin N-terminus Apt1 PF10351.9 ETS65005.1 - 0.13 11.1 16.3 0.0067 15.3 11.1 1.5 2 0 0 2 2 2 0 Golgi-body localisation protein domain SDA1 PF05285.12 ETS65005.1 - 0.36 10.2 18.0 0.65 9.4 5.4 2.2 2 0 0 2 2 2 0 SDA1 CDC45 PF02724.14 ETS65005.1 - 1.8 6.7 18.4 2.1 6.5 2.4 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF572 PF04502.13 ETS65005.1 - 2 8.0 8.6 3.9 7.0 8.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) Macoilin PF09726.9 ETS65005.1 - 3.6 6.0 16.4 5.6 5.4 16.4 1.2 1 0 0 1 1 1 0 Macoilin family Peroxin-3 PF04882.12 ETS65005.1 - 5.5 5.9 12.8 9.2 5.1 12.8 1.3 1 0 0 1 1 1 0 Peroxin-3 Sec1 PF00995.23 ETS65006.1 - 3.5e-123 412.9 0.0 4.4e-123 412.5 0.0 1.1 1 0 0 1 1 1 1 Sec1 family DUF1045 PF06299.12 ETS65006.1 - 0.028 14.4 0.4 0.064 13.2 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1045) PMEI PF04043.15 ETS65006.1 - 0.15 12.4 0.1 0.38 11.1 0.1 1.6 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor NIF PF03031.18 ETS65007.1 - 1.2e-51 174.5 0.0 1.9e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2291 PF10054.9 ETS65008.1 - 0.041 13.6 0.7 0.067 12.9 0.7 1.3 1 0 0 1 1 1 0 Predicted periplasmic lipoprotein (DUF2291) SKI PF01202.22 ETS65009.1 - 5.1e-12 46.2 0.0 2.5e-09 37.4 0.0 2.3 2 0 0 2 2 2 2 Shikimate kinase AAA_33 PF13671.6 ETS65009.1 - 2.8e-07 30.8 0.2 6.7e-06 26.3 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETS65009.1 - 4e-06 27.4 0.1 0.00016 22.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 ETS65009.1 - 0.00066 19.9 0.0 0.0038 17.4 0.0 2.1 2 1 0 2 2 2 1 Cytidylate kinase-like family AAA_22 PF13401.6 ETS65009.1 - 0.00066 20.0 0.8 0.07 13.4 0.4 2.8 2 1 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 ETS65009.1 - 0.0016 18.2 0.1 0.0033 17.2 0.0 1.6 2 0 0 2 2 2 1 Cytidylate kinase AAA_16 PF13191.6 ETS65009.1 - 0.0064 16.9 0.3 0.01 16.2 0.3 1.6 1 1 0 1 1 1 1 AAA ATPase domain dNK PF01712.19 ETS65009.1 - 0.0073 16.2 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 2 Deoxynucleoside kinase APS_kinase PF01583.20 ETS65009.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 1 0 1 1 1 0 Adenylylsulphate kinase AAA_17 PF13207.6 ETS65009.1 - 0.012 16.0 0.2 0.068 13.6 0.1 2.4 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ETS65009.1 - 0.016 14.5 0.1 0.037 13.3 0.1 1.7 1 0 0 1 1 1 0 Zeta toxin CoaE PF01121.20 ETS65009.1 - 0.021 14.5 0.0 0.042 13.5 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase Herpes_Helicase PF02689.14 ETS65009.1 - 0.024 12.6 0.1 0.066 11.1 0.0 1.6 2 0 0 2 2 2 0 Helicase ABC_tran PF00005.27 ETS65009.1 - 0.029 14.9 0.1 0.049 14.1 0.1 1.6 1 1 0 1 1 1 0 ABC transporter DUF2075 PF09848.9 ETS65009.1 - 0.036 13.3 0.0 0.076 12.2 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 ETS65009.1 - 0.038 14.4 0.2 0.11 12.9 0.1 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ETS65009.1 - 0.06 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.23 ETS65009.1 - 0.17 12.0 3.5 0.23 11.5 0.6 2.2 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ribosomal_L23 PF00276.20 ETS65010.1 - 1.1e-05 25.7 0.0 2.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 Pkinase PF00069.25 ETS65012.1 - 2.1e-65 220.7 0.0 2.8e-65 220.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65012.1 - 1.8e-33 116.0 0.0 2.4e-33 115.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS65012.1 - 1.4e-09 37.7 0.0 2.3e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETS65012.1 - 0.00094 19.2 0.6 0.0024 17.8 0.6 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETS65012.1 - 0.0011 18.3 0.1 0.0021 17.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETS65012.1 - 0.0022 16.8 0.0 0.0038 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETS65012.1 - 0.0043 16.1 0.1 0.0061 15.5 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Histidinol_dh PF00815.20 ETS65013.1 - 1.5e-157 524.8 1.7 3.2e-157 523.7 1.7 1.6 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 ETS65013.1 - 1.7e-22 79.0 0.2 3e-22 78.2 0.2 1.4 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 ETS65013.1 - 1.7e-14 54.0 0.3 5.8e-14 52.3 0.3 2.0 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 ETS65013.1 - 0.013 15.7 0.1 0.03 14.5 0.1 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Peptidase_S10 PF00450.22 ETS65014.1 - 2.8e-93 313.6 0.0 7.1e-93 312.3 0.0 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase CRAL_TRIO PF00650.20 ETS65015.1 - 8.6e-34 116.6 0.0 1.3e-33 116.0 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ETS65015.1 - 7.8e-16 58.0 0.2 1.6e-15 57.0 0.2 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain SAB PF04382.13 ETS65015.1 - 0.078 13.1 0.3 0.34 11.0 0.3 2.1 1 0 0 1 1 1 0 SAB domain NPBW PF15180.6 ETS65015.1 - 0.14 12.0 0.1 0.35 10.7 0.1 1.6 1 0 0 1 1 1 0 Neuropeptides B and W AhpC-TSA_2 PF13911.6 ETS65016.1 - 4.9e-13 49.2 0.0 1e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme Redoxin PF08534.10 ETS65016.1 - 1.5e-07 31.2 0.0 3.7e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ETS65016.1 - 3.6e-07 30.1 0.0 8.2e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family GCV_T PF01571.21 ETS65017.1 - 2.1e-07 30.6 0.0 3.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain HMG_box PF00505.19 ETS65019.1 - 2.5e-18 66.2 13.7 9.6e-11 42.0 0.8 3.6 2 2 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ETS65019.1 - 1e-16 61.3 11.3 8.7e-10 39.1 0.4 3.0 3 0 0 3 3 3 2 HMG-box domain MlaC PF05494.12 ETS65019.1 - 0.018 14.8 2.3 0.5 10.1 0.2 2.3 2 0 0 2 2 2 0 MlaC protein KRAB PF01352.27 ETS65019.1 - 0.14 11.8 2.0 9.2 6.0 0.1 2.4 2 0 0 2 2 2 0 KRAB box TTSSLRR PF12468.8 ETS65019.1 - 2.6 8.4 6.2 0.24 11.7 0.7 2.3 2 0 0 2 2 2 0 Type III secretion system leucine rich repeat protein Sporozoite_P67 PF05642.11 ETS65020.1 - 0.15 10.1 0.4 0.2 9.7 0.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen KH_1 PF00013.29 ETS65021.1 - 2.9e-08 33.4 1.2 2.8e-06 27.0 0.3 2.5 2 0 0 2 2 2 2 KH domain Trp_repressor PF01371.19 ETS65021.1 - 0.068 13.3 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 Trp repressor protein DUF2786 PF10979.8 ETS65021.1 - 7.5 6.6 10.9 5.8 6.9 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) DUF1769 PF08588.10 ETS65022.1 - 2.7e-26 91.5 0.2 6.3e-26 90.3 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1769) GCS PF03074.16 ETS65023.1 - 2e-173 576.9 0.0 2.5e-173 576.6 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase CDC14 PF08045.11 ETS65024.1 - 0.076 12.1 0.3 0.25 10.4 0.3 1.9 1 0 0 1 1 1 0 Cell division control protein 14, SIN component BRAP2 PF07576.12 ETS65025.1 - 2.7e-27 94.9 0.1 5.2e-27 94.0 0.1 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 ETS65025.1 - 1.3e-18 67.1 5.2 1.3e-18 67.1 5.2 1.9 2 0 0 2 2 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 ETS65025.1 - 8.6e-08 32.4 10.1 8.6e-08 32.4 10.1 2.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETS65025.1 - 3.6e-06 26.7 9.5 1e-05 25.3 9.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS65025.1 - 0.0001 22.1 8.8 0.0001 22.1 8.8 1.9 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETS65025.1 - 0.00017 21.8 7.6 0.00017 21.8 7.6 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETS65025.1 - 0.0002 21.3 7.9 0.00057 19.9 7.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETS65025.1 - 0.00027 20.8 8.1 0.00027 20.8 8.1 2.2 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETS65025.1 - 0.00029 20.5 5.4 0.00029 20.5 5.4 2.0 2 0 0 2 2 1 1 RING-like zinc finger SPX PF03105.19 ETS65025.1 - 0.00049 20.1 6.1 0.00049 20.1 6.1 1.9 2 0 0 2 2 2 1 SPX domain Phage_GP20 PF06810.11 ETS65025.1 - 0.0021 17.9 6.8 0.0036 17.1 6.8 1.3 1 0 0 1 1 1 1 Phage minor structural protein GP20 zf-C3HC4_3 PF13920.6 ETS65025.1 - 0.0055 16.5 6.9 0.0055 16.5 6.9 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ETS65025.1 - 0.017 14.9 5.9 0.05 13.4 5.9 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Cob_adeno_trans PF01923.18 ETS65025.1 - 0.06 13.5 2.1 0.13 12.4 2.1 1.5 1 0 0 1 1 1 0 Cobalamin adenosyltransferase RRM_1 PF00076.22 ETS65025.1 - 0.089 12.6 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BLOC1_2 PF10046.9 ETS65025.1 - 0.14 12.5 4.2 0.35 11.2 0.5 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-UBP_var PF17807.1 ETS65025.1 - 0.2 11.4 1.3 0.43 10.4 1.3 1.5 1 0 0 1 1 1 0 Variant UBP zinc finger bZIP_1 PF00170.21 ETS65025.1 - 0.46 10.6 5.1 0.095 12.8 1.1 2.0 2 0 0 2 2 1 0 bZIP transcription factor MbeD_MobD PF04899.12 ETS65025.1 - 1.9 8.7 7.2 1.3 9.2 0.2 2.6 2 0 0 2 2 2 0 MbeD/MobD like DUF4407 PF14362.6 ETS65025.1 - 2.4 7.4 10.9 5.4 6.3 10.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 ETS65025.1 - 2.6 7.9 6.2 2.9 7.7 5.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 ETS65025.1 - 3.3 8.0 13.0 34 4.7 13.1 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Rtf2 PF04641.12 ETS65025.1 - 4.4 6.6 7.4 1.8 7.9 0.3 2.6 2 0 0 2 2 2 0 Rtf2 RING-finger bZIP_2 PF07716.15 ETS65025.1 - 5.8 7.1 12.7 1.7 8.8 2.9 3.2 3 0 0 3 3 3 0 Basic region leucine zipper YabA PF06156.13 ETS65025.1 - 5.8 7.6 7.7 2.2 9.0 2.6 2.3 1 1 1 2 2 2 0 Initiation control protein YabA Aldo_ket_red PF00248.21 ETS65026.1 - 1.3e-50 172.3 0.1 1e-49 169.3 0.1 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family TPP_enzyme_N PF02776.18 ETS65027.1 - 8.8e-34 116.6 0.1 1.6e-33 115.8 0.1 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 ETS65027.1 - 2.3e-24 85.7 0.0 4.6e-24 84.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ETS65027.1 - 5.4e-14 52.2 0.0 3.5e-13 49.6 0.0 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain YdaT_toxin PF06254.11 ETS65027.1 - 0.022 15.3 0.0 4.8 7.8 0.0 2.5 2 0 0 2 2 2 0 Putative bacterial toxin ydaT TauD PF02668.16 ETS65028.1 - 1.4e-54 185.7 0.4 1.9e-54 185.3 0.4 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TP_methylase PF00590.20 ETS65030.1 - 2e-40 139.0 0.6 5.3e-40 137.6 0.6 1.7 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 ETS65030.1 - 1.2e-11 44.9 0.1 9.1e-11 42.1 0.1 2.3 1 1 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 ETS65030.1 - 1.7e-09 36.9 0.2 3.7e-09 35.9 0.2 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 ETS65030.1 - 1.8e-09 37.1 1.3 1.8e-06 27.5 0.3 2.4 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal SOBP PF15279.6 ETS65030.1 - 0.83 10.2 6.2 1.4 9.5 6.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein COX17 PF05051.13 ETS65031.1 - 1.1e-19 70.4 6.9 1.7e-19 69.8 6.9 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) UPF0203 PF05254.12 ETS65031.1 - 0.0014 18.8 2.5 0.002 18.4 2.5 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) Peptidase_M16_C PF05193.21 ETS65032.1 - 7.2e-18 65.3 0.0 8.4e-14 52.0 0.0 3.3 3 1 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ETS65032.1 - 3.1e-06 27.2 0.0 8.1e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Serglycin PF04360.12 ETS65032.1 - 2 8.4 4.8 4.2 7.3 4.8 1.4 1 0 0 1 1 1 0 Serglycin AF-4 PF05110.13 ETS65032.1 - 3 5.8 7.7 4.5 5.2 7.7 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Sdh_cyt PF01127.22 ETS65033.1 - 8.9e-24 83.8 3.8 1.2e-23 83.4 3.8 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Rhabdo_M1 PF03342.13 ETS65034.1 - 0.0053 16.1 6.1 0.011 15.1 6.1 1.4 1 0 0 1 1 1 1 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein) APG6_N PF17675.1 ETS65034.1 - 6.2 7.3 22.0 9.4 6.8 22.0 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Z1 PF10593.9 ETS65034.1 - 6.9 6.1 8.3 9.8 5.6 8.3 1.2 1 0 0 1 1 1 0 Z1 domain Neur_chan_memb PF02932.16 ETS65034.1 - 7.7 6.5 7.7 11 6.0 7.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DNApol_Exo PF18136.1 ETS65035.1 - 6.7e-87 291.2 0.0 6.2e-78 261.8 0.0 2.5 2 0 0 2 2 2 2 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 ETS65035.1 - 9.6e-49 166.4 0.0 2e-48 165.3 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A DUF4404 PF14357.6 ETS65035.1 - 7.2 7.3 6.5 3.9 8.2 1.8 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) WD40 PF00400.32 ETS65036.1 - 0.31 12.0 23.8 0.62 11.0 0.4 5.3 6 1 0 6 6 6 0 WD domain, G-beta repeat RF-1 PF00472.20 ETS65037.1 - 1.9e-22 79.4 2.0 2.8e-22 78.8 2.0 1.2 1 0 0 1 1 1 1 RF-1 domain adh_short PF00106.25 ETS65038.1 - 7.3e-45 152.8 1.1 2.2e-23 82.8 0.1 2.6 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETS65038.1 - 3.4e-44 151.1 0.1 1.3e-22 80.5 0.0 2.4 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS65038.1 - 1.2e-05 25.3 0.3 3.1e-05 23.9 0.1 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ETS65038.1 - 0.15 11.4 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Spt20 PF12090.8 ETS65039.1 - 1.2e-32 113.4 0.0 9.5e-20 71.2 0.0 6.3 5 1 0 5 5 5 3 Spt20 family PPP4R2 PF09184.11 ETS65039.1 - 0.11 12.0 15.1 0.015 14.9 10.7 1.8 2 0 0 2 2 2 0 PPP4R2 NDK PF00334.19 ETS65040.1 - 4e-33 114.3 0.0 7e-33 113.5 0.0 1.3 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Cnd2 PF05786.14 ETS65041.1 - 9.5e-166 553.7 0.0 9.5e-166 553.7 0.0 2.3 1 1 1 2 2 2 1 Condensin complex subunit 2 CNDH2_N PF06278.11 ETS65041.1 - 0.012 15.8 0.0 0.039 14.2 0.0 1.8 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Beta_helix_2 PF18835.1 ETS65041.1 - 0.037 13.8 0.1 0.14 11.9 0.1 1.9 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase PBP1_TM PF14812.6 ETS65041.1 - 0.1 13.0 34.1 0.082 13.3 7.8 3.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2462 PF09495.10 ETS65042.1 - 1.2e-19 70.7 14.3 1.2e-19 70.7 14.3 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) Y_phosphatase2 PF03162.13 ETS65043.1 - 2.9e-58 196.1 0.0 6.5e-58 195.0 0.0 1.6 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ETS65043.1 - 2.2e-07 31.1 0.0 3.9e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ETS65043.1 - 0.00058 19.7 0.0 0.0019 18.0 0.0 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETS65043.1 - 0.00073 19.2 0.0 0.0028 17.2 0.0 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PolyA_pol PF01743.20 ETS65044.1 - 8.5e-22 77.9 0.0 1.7e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ETS65044.1 - 5.9e-05 22.8 0.1 0.00015 21.5 0.1 1.6 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A SRP19 PF01922.17 ETS65045.1 - 2e-25 89.5 0.0 4.8e-25 88.3 0.0 1.6 1 0 0 1 1 1 1 SRP19 protein HTH_32 PF13565.6 ETS65045.1 - 0.23 12.1 1.3 5.3 7.7 0.2 2.4 2 0 0 2 2 2 0 Homeodomain-like domain CN_hydrolase PF00795.22 ETS65047.1 - 3.9e-55 187.0 0.2 4.4e-55 186.8 0.2 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Exo_endo_phos PF03372.23 ETS65048.1 - 5.6e-08 32.6 0.0 1e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 ETS65048.1 - 0.14 13.1 6.9 0.38 11.7 0.2 4.8 5 0 0 5 5 5 0 WD domain, G-beta repeat NUDIX PF00293.28 ETS65049.1 - 0.0068 16.5 0.1 0.89 9.6 0.1 2.9 1 1 0 1 1 1 1 NUDIX domain Coilin_N PF15862.5 ETS65051.1 - 0.08 12.7 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Coilin N-terminus SOG2 PF10428.9 ETS65051.1 - 0.79 8.8 13.0 0.86 8.7 13.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 ETS65051.1 - 1.2 8.9 11.4 1.4 8.8 11.4 1.1 1 0 0 1 1 1 0 SPX domain Plasmodium_Vir PF05795.11 ETS65051.1 - 1.7 7.9 4.2 1.8 7.9 4.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 ETS65051.1 - 4.8 5.9 14.8 5.7 5.7 14.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Glypican PF01153.19 ETS65051.1 - 8.4 5.1 6.5 10 4.8 6.5 1.1 1 0 0 1 1 1 0 Glypican LtrA PF06772.11 ETS65052.1 - 2.1e-31 109.5 22.9 1.9e-17 63.5 15.9 2.1 2 0 0 2 2 2 2 Bacterial low temperature requirement A protein (LtrA) Trp_oprn_chp PF09534.10 ETS65052.1 - 0.022 14.6 4.1 0.61 9.8 0.0 3.3 3 0 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RNB PF00773.19 ETS65053.1 - 2.2e-47 162.0 0.0 8.8e-47 160.0 0.0 1.9 1 1 0 1 1 1 1 RNB domain PapA_C PF16911.5 ETS65053.1 - 0.091 12.8 0.0 0.42 10.7 0.0 2.1 1 0 0 1 1 1 0 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus Ras PF00071.22 ETS65054.1 - 6.2e-35 120.2 0.1 7.8e-35 119.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS65054.1 - 5.1e-26 91.3 0.1 7.5e-26 90.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS65054.1 - 1.3e-07 31.2 0.0 1.7e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETS65054.1 - 1.9e-06 27.4 0.1 2.6e-06 27.0 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 ETS65054.1 - 0.0025 16.7 0.2 0.12 11.2 0.0 2.0 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) TniB PF05621.11 ETS65054.1 - 0.024 14.1 0.0 2.8 7.3 0.0 2.4 2 1 0 2 2 2 0 Bacterial TniB protein SRPRB PF09439.10 ETS65054.1 - 0.1 12.1 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETS65054.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase PAPA-1 PF04795.12 ETS65055.1 - 1.5e-26 93.0 5.8 1.5e-26 93.0 5.8 4.4 3 2 1 4 4 4 1 PAPA-1-like conserved region MCR_gamma PF02240.16 ETS65056.1 - 0.05 12.8 0.0 0.094 11.9 0.0 1.4 1 0 0 1 1 1 0 Methyl-coenzyme M reductase gamma subunit DUF2249 PF10006.9 ETS65056.1 - 0.079 12.8 1.3 50 3.9 0.2 3.6 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2249) UBN_AB PF14075.6 ETS65058.1 - 2.3e-44 151.7 0.9 2.3e-44 151.7 0.9 2.0 2 0 0 2 2 2 1 Ubinuclein conserved middle domain HUN PF08729.10 ETS65058.1 - 4.3e-13 49.0 2.2 4.3e-13 49.0 2.2 2.5 2 0 0 2 2 2 1 HPC2 and ubinuclein domain CDC45 PF02724.14 ETS65058.1 - 0.0035 15.7 5.1 0.0035 15.7 5.1 2.2 2 0 0 2 2 2 1 CDC45-like protein NOA36 PF06524.12 ETS65058.1 - 5.4 6.2 17.3 13 5.0 17.3 1.6 1 0 0 1 1 1 0 NOA36 protein DUF815 PF05673.13 ETS65059.1 - 0.011 14.9 0.0 0.012 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NMD3 PF04981.13 ETS65060.1 - 5.1e-85 284.8 3.2 7.5e-85 284.3 3.2 1.3 1 0 0 1 1 1 1 NMD3 family DZR PF12773.7 ETS65060.1 - 0.0024 17.9 5.9 0.32 11.0 5.9 2.9 1 1 0 1 1 1 1 Double zinc ribbon Skp1 PF01466.19 ETS65060.1 - 0.14 12.3 3.0 0.32 11.1 3.0 1.6 1 0 0 1 1 1 0 Skp1 family, dimerisation domain DUF5321 PF17254.2 ETS65060.1 - 0.21 11.0 3.7 0.57 9.6 3.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5321) Whi5 PF08528.11 ETS65062.1 - 1.6e-10 40.4 0.0 2.7e-10 39.6 0.0 1.4 1 0 0 1 1 1 1 Whi5 like TRAPP PF04051.16 ETS65063.1 - 3.2e-40 137.2 0.0 4.2e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Haemagg_act PF05860.13 ETS65063.1 - 0.025 14.5 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 haemagglutination activity domain MetallophosN PF16371.5 ETS65063.1 - 0.17 12.2 0.0 0.43 10.9 0.0 1.6 1 0 0 1 1 1 0 N terminal of Calcineurin-like phosphoesterase dsDNA_bind PF01984.20 ETS65064.1 - 1e-35 122.3 1.0 1.3e-35 122.0 1.0 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Steroid_dh PF02544.16 ETS65065.1 - 2.9e-25 89.0 5.1 5.7e-19 68.6 5.4 4.4 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 ETS65065.1 - 0.0003 20.4 0.2 0.0005 19.6 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) JmjC PF02373.22 ETS65066.1 - 2.5e-15 56.9 0.0 6.1e-15 55.7 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ETS65066.1 - 0.00097 18.9 0.0 0.1 12.3 0.0 2.8 2 1 0 2 2 2 1 Cupin-like domain FYVE PF01363.21 ETS65066.1 - 0.38 10.9 11.3 0.14 12.4 6.9 2.3 2 0 0 2 2 2 0 FYVE zinc finger zf-B_box PF00643.24 ETS65066.1 - 1.2 9.4 9.1 3.3 7.9 9.1 1.7 1 0 0 1 1 1 0 B-box zinc finger Nse4-Nse3_bdg PF15412.6 ETS65066.1 - 1.8 8.7 4.0 2.6 8.2 0.2 2.5 2 0 0 2 2 2 0 Binding domain of Nse4/EID3 to Nse3-MAGE CEBP_ZZ PF16366.5 ETS65066.1 - 2.1 8.7 9.5 6.1 7.2 9.5 1.8 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-AN1 PF01428.16 ETS65066.1 - 7.4 6.8 15.8 0.11 12.6 8.0 2.0 2 0 0 2 2 2 0 AN1-like Zinc finger IBR PF01485.21 ETS65066.1 - 9.1 6.6 14.0 0.11 12.8 5.2 2.3 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain FANCD2OS PF15124.6 ETS65067.1 - 0.095 12.9 3.7 0.22 11.8 0.6 2.2 2 0 0 2 2 2 0 FANCD2 opposite strand protein MAGI_u1 PF16663.5 ETS65067.1 - 0.61 10.2 5.4 1.8 8.7 3.7 2.4 2 0 0 2 2 2 0 Unstructured region on MAGI Maf1 PF09174.10 ETS65069.1 - 3.2e-38 131.6 0.0 1.8e-31 109.6 0.0 2.3 2 0 0 2 2 2 2 Maf1 regulator TruD PF01142.18 ETS65070.1 - 4.1e-70 236.7 0.0 1.4e-65 221.7 0.0 4.3 3 1 0 3 3 3 2 tRNA pseudouridine synthase D (TruD) OPT PF03169.15 ETS65071.1 - 2e-151 505.7 47.4 2.3e-151 505.5 47.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein FA_hydroxylase PF04116.13 ETS65072.1 - 1.5e-23 83.6 11.0 1.5e-23 83.6 11.0 2.2 2 0 0 2 2 2 2 Fatty acid hydroxylase superfamily Glyco_hydro_3_C PF01915.22 ETS65073.1 - 1.9e-48 165.1 0.1 3e-48 164.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ETS65073.1 - 2.8e-33 115.7 0.0 3.4e-32 112.1 0.0 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ETS65073.1 - 3.9e-19 68.5 0.1 9.1e-19 67.3 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PGAP1 PF07819.13 ETS65074.1 - 8.8e-59 199.0 0.0 1.3e-58 198.5 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 ETS65074.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 ETS65074.1 - 0.17 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 TolA_bind_tri PF16331.5 ETS65074.1 - 0.18 11.9 0.1 0.44 10.6 0.1 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF2894 PF11445.8 ETS65076.1 - 2.1 8.8 9.2 2.5 8.5 0.7 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF2894) DUF3094 PF11293.8 ETS65079.1 - 0.051 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) Abhydrolase_3 PF07859.13 ETS65082.1 - 4.5e-17 62.6 0.4 8.5e-16 58.4 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETS65082.1 - 6e-10 38.5 0.0 1.4e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ETS65082.1 - 0.082 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF3605 PF12239.8 ETS65083.1 - 1.5e-21 77.3 0.0 2.6e-13 50.6 0.0 2.7 2 1 0 2 2 2 2 Protein of unknown function (DUF3605) GMC_oxred_N PF00732.19 ETS65084.1 - 3.5e-57 194.1 0.0 4.5e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS65084.1 - 1.8e-29 103.1 0.4 4.5e-29 101.8 0.1 1.9 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ETS65084.1 - 1.3e-05 24.5 0.3 0.00018 20.7 1.1 2.0 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 ETS65084.1 - 1.7e-05 24.9 0.8 0.00012 22.3 1.4 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 ETS65084.1 - 0.00035 19.7 0.1 0.00054 19.1 0.1 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein Thi4 PF01946.17 ETS65084.1 - 0.00093 18.5 0.4 0.0017 17.7 0.4 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ETS65084.1 - 0.0039 16.5 2.5 0.0073 15.6 1.6 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETS65084.1 - 0.0072 16.0 3.0 0.011 15.3 3.0 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETS65084.1 - 0.011 15.0 1.9 0.078 12.2 1.3 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS65084.1 - 0.072 11.8 0.4 0.17 10.5 0.4 1.6 1 0 0 1 1 1 0 HI0933-like protein Solute_trans_a PF03619.16 ETS65085.1 - 2.7e-83 279.5 26.3 3.4e-83 279.2 26.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DPM3 PF08285.11 ETS65085.1 - 1.9 8.8 10.1 0.05 13.8 2.1 2.4 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Zn_clus PF00172.18 ETS65086.1 - 1.2e-05 25.3 8.0 2.3e-05 24.4 8.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aldedh PF00171.22 ETS65087.1 - 6.8e-129 430.4 1.5 8.4e-129 430.1 1.5 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETS65087.1 - 0.088 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) HORMA PF02301.18 ETS65088.1 - 2.5e-23 82.8 0.0 3e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 ETS65088.1 - 0.013 15.5 0.1 0.035 14.1 0.1 1.7 1 1 0 1 1 1 0 Autophagy-related protein 101 Potex_coat PF06184.11 ETS65088.1 - 0.023 14.3 0.0 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 Potexvirus coat protein bacHORMA_2 PF18173.1 ETS65088.1 - 0.087 12.7 0.2 0.41 10.5 0.2 1.9 1 1 1 2 2 2 0 Bacterial HORMA domain 2 His_Phos_1 PF00300.22 ETS65089.1 - 4.8e-17 62.3 2.2 4.8e-14 52.5 2.2 3.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) GMP_synt_C PF00958.22 ETS65090.1 - 2.6e-43 146.0 0.0 5e-43 145.1 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 ETS65090.1 - 1.3e-37 129.4 0.0 3.5e-37 128.0 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 ETS65090.1 - 1e-11 44.4 0.2 2.6e-07 30.0 0.1 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 ETS65090.1 - 3.2e-09 36.9 0.0 6.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 ETS65090.1 - 5.8e-05 22.0 0.2 0.00011 21.1 0.2 1.4 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 ETS65090.1 - 0.0001 21.9 0.0 0.00018 21.2 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 ETS65090.1 - 0.0013 18.1 0.2 0.0021 17.4 0.2 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 ETS65090.1 - 0.0017 17.9 0.1 0.01 15.4 0.1 2.0 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 ETS65090.1 - 0.015 15.3 0.0 0.024 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family sCache_like PF16736.5 ETS65090.1 - 0.067 13.3 0.3 0.12 12.4 0.3 1.3 1 0 0 1 1 1 0 Single Cache-like ATP_bind_3 PF01171.20 ETS65090.1 - 0.16 11.7 0.3 0.36 10.6 0.0 1.7 2 0 0 2 2 2 0 PP-loop family mIF3 PF14877.6 ETS65091.1 - 0.00064 19.4 0.1 0.0017 18.0 0.1 1.8 1 1 0 1 1 1 1 Mitochondrial translation initiation factor IF3_N PF05198.16 ETS65091.1 - 0.0039 17.4 0.0 0.015 15.5 0.0 1.9 1 1 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain IF3_C PF00707.22 ETS65091.1 - 0.062 13.3 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-3, C-terminal domain ATP-synt_E_2 PF08112.11 ETS65091.1 - 0.099 12.9 0.0 0.36 11.1 0.0 1.9 1 0 0 1 1 1 0 ATP synthase epsilon subunit WD40 PF00400.32 ETS65092.1 - 2.2e-11 44.1 4.1 0.0015 19.3 0.1 5.6 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS65092.1 - 7.1e-06 26.2 0.1 0.0085 16.4 0.0 3.7 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Cys_Met_Meta_PP PF01053.20 ETS65093.1 - 2e-18 66.1 0.0 5.1e-18 64.8 0.0 1.7 2 1 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ETS65093.1 - 0.0039 16.4 0.0 0.0065 15.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Corazonin PF17308.2 ETS65093.1 - 0.25 11.7 0.8 0.36 11.2 0.0 1.6 2 0 0 2 2 2 0 Pro-corazonin CTD_bind PF04818.13 ETS65094.1 - 0.0053 17.6 0.0 0.015 16.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. FliX PF10768.9 ETS65094.1 - 0.06 13.9 3.1 0.2 12.2 3.1 2.0 1 0 0 1 1 1 0 Class II flagellar assembly regulator CFIA_Pcf11 PF11526.8 ETS65094.1 - 0.26 11.8 2.9 0.73 10.3 0.2 2.9 2 1 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 ParA PF10609.9 ETS65095.1 - 4e-84 281.9 0.0 8.8e-84 280.8 0.0 1.5 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ETS65095.1 - 2.5e-06 27.6 0.0 0.00033 20.7 0.2 3.0 3 1 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 ETS65095.1 - 8.4e-05 21.9 0.1 0.0029 16.9 0.6 2.2 2 0 0 2 2 2 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 ETS65095.1 - 0.035 14.0 0.0 0.075 12.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase PcrB PF01884.17 ETS65095.1 - 0.035 13.6 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 PcrB family AAA_31 PF13614.6 ETS65095.1 - 0.076 12.9 0.3 0.48 10.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_26 PF13500.6 ETS65095.1 - 0.11 12.3 0.0 0.52 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ETS65095.1 - 0.13 11.5 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Imm45 PF15572.6 ETS65095.1 - 0.18 12.2 0.0 0.5 10.8 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 45 ABC2_membrane PF01061.24 ETS65096.1 - 3.4e-75 252.0 68.0 1.3e-39 135.8 26.0 3.3 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 ETS65096.1 - 2e-35 122.3 0.0 1.6e-16 61.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 ETS65096.1 - 1.2e-32 111.6 4.0 2.6e-30 104.2 0.3 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 ETS65096.1 - 6.7e-12 45.9 0.3 8.1e-11 42.4 0.0 2.5 2 0 0 2 2 2 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 ETS65096.1 - 4.6e-06 26.0 41.6 0.011 14.9 16.1 3.7 3 1 0 3 3 3 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 ETS65096.1 - 7.3e-06 26.0 0.1 3.2e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ETS65096.1 - 2.3e-05 24.8 0.1 0.0025 18.2 0.1 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 ETS65096.1 - 0.0004 20.0 0.0 0.0042 16.7 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETS65096.1 - 0.0029 17.9 0.1 0.051 13.9 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ETS65096.1 - 0.0041 17.0 0.0 1.6 8.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 ETS65096.1 - 0.0047 16.8 0.1 0.18 11.7 0.0 2.5 2 0 0 2 2 2 1 NACHT domain dNK PF01712.19 ETS65096.1 - 0.011 15.7 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_29 PF13555.6 ETS65096.1 - 0.016 14.9 0.2 0.12 12.2 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ETS65096.1 - 0.042 13.6 0.1 0.72 9.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ETS65096.1 - 0.043 13.2 0.0 2.3 7.6 0.0 3.1 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain TsaE PF02367.17 ETS65096.1 - 0.053 13.5 0.1 0.49 10.4 0.1 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ETS65096.1 - 0.082 13.3 0.1 4.2 7.8 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ETS65096.1 - 0.091 13.2 0.3 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ETS65096.1 - 0.12 12.4 0.2 0.9 9.6 0.1 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 ETS65096.1 - 0.22 11.1 0.8 0.93 9.1 0.3 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NAD_binding_4 PF07993.12 ETS65097.1 - 1.5e-13 50.6 0.0 2.2e-11 43.4 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 ETS65097.1 - 2.6e-10 39.8 0.0 6.8e-10 38.4 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETS65097.1 - 1.4e-09 37.8 0.2 5e-09 36.0 0.2 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETS65097.1 - 0.00046 19.7 0.7 0.00079 18.9 0.1 1.6 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 ETS65097.1 - 0.051 13.5 0.5 0.86 9.5 0.3 2.6 2 1 0 2 2 2 0 KR domain NmrA PF05368.13 ETS65097.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.4 1 0 0 1 1 1 0 NmrA-like family 2-Hacid_dh_C PF02826.19 ETS65098.1 - 1e-38 132.4 0.0 1.1e-37 129.1 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETS65098.1 - 1.8e-25 89.2 0.0 4.2e-25 88.0 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain F420_oxidored PF03807.17 ETS65098.1 - 3.9e-05 24.1 0.0 0.0001 22.8 0.0 1.8 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Mito_carr PF00153.27 ETS65099.1 - 5.1e-52 173.8 6.8 9e-19 67.2 0.2 3.6 4 0 0 4 4 4 3 Mitochondrial carrier protein DUF389 PF04087.14 ETS65099.1 - 3.3 7.7 5.9 0.22 11.6 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF389) TPR_2 PF07719.17 ETS65100.1 - 4.3e-27 92.0 17.4 0.00069 19.5 0.1 9.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETS65100.1 - 7e-23 79.5 1.4 0.00051 19.7 0.0 8.7 9 0 0 9 9 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS65100.1 - 5.1e-20 71.5 15.3 1.4e-08 34.8 3.0 4.7 4 0 0 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETS65100.1 - 6.6e-12 44.6 0.0 0.016 15.4 0.0 7.4 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETS65100.1 - 1.1e-08 35.3 28.4 0.00015 22.0 0.1 7.3 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETS65100.1 - 1.4e-08 34.3 0.1 0.032 13.9 0.0 5.7 4 1 1 5 5 5 2 TPR repeat TPR_14 PF13428.6 ETS65100.1 - 2e-07 31.3 35.6 0.047 14.5 0.2 9.2 5 3 4 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETS65100.1 - 3.9e-06 27.4 46.0 0.0002 21.9 1.7 8.1 7 1 1 8 8 6 4 Tetratricopeptide repeat TPR_9 PF13371.6 ETS65100.1 - 7.7e-06 26.0 27.1 0.051 13.7 0.4 6.4 5 2 3 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETS65100.1 - 2.1e-05 24.9 16.4 0.37 11.5 0.0 8.5 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETS65100.1 - 3.7e-05 23.4 10.8 1.6 8.7 0.0 6.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETS65100.1 - 5.8e-05 23.5 23.9 0.049 14.1 0.4 7.3 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETS65100.1 - 9e-05 22.6 0.2 13 6.5 0.0 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ETS65100.1 - 0.0002 21.0 0.8 0.0057 16.3 0.2 3.1 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 ETS65100.1 - 0.0019 18.1 14.7 0.99 9.6 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETS65100.1 - 0.0067 16.2 1.9 2.2 8.0 0.4 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 ETS65100.1 - 5 7.3 10.4 78 3.5 0.0 5.0 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat F-box PF00646.33 ETS65101.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 ETS65101.1 - 0.16 11.9 0.4 0.36 10.8 0.4 1.6 1 0 0 1 1 1 0 F-box-like TOM13 PF08219.11 ETS65102.1 - 8.4e-10 38.5 0.0 1.9e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Outer membrane protein TOM13 E1-E2_ATPase PF00122.20 ETS65103.1 - 1.2e-25 90.1 0.0 1.2e-25 90.1 0.0 3.6 4 1 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ETS65103.1 - 6e-13 49.6 0.4 3.9e-05 24.0 0.0 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETS65103.1 - 3.8e-08 33.3 0.0 1.3e-07 31.6 0.0 1.8 2 0 0 2 2 2 1 Cation transport ATPase (P-type) P5-ATPase PF12409.8 ETS65103.1 - 4.3e-07 30.1 0.0 1e-06 28.9 0.0 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter Cation_ATPase_N PF00690.26 ETS65103.1 - 4.6e-05 23.0 0.0 0.00012 21.7 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Glyco_hydro_15 PF00723.21 ETS65104.1 - 1.4e-82 277.9 2.1 2e-82 277.4 2.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 DUF1921 PF09081.10 ETS65104.1 - 0.011 15.9 0.2 0.039 14.2 0.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1921) Abhydrolase_6 PF12697.7 ETS65105.1 - 7.4e-16 59.4 0.4 1.6e-15 58.3 0.4 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETS65105.1 - 6.7e-15 55.4 0.1 2.6e-11 43.7 0.2 2.8 2 1 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS65105.1 - 4.2e-07 29.5 0.0 0.00013 21.3 0.0 2.5 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ETS65105.1 - 0.0007 19.7 0.0 0.0017 18.5 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Rad60-SLD_2 PF13881.6 ETS65106.1 - 4.9e-14 52.4 0.3 1.1e-13 51.3 0.0 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like WD40 PF00400.32 ETS65107.1 - 6e-21 74.4 0.5 1e-06 29.3 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ERCC3_RAD25_C PF16203.5 ETS65108.1 - 2.5e-124 413.4 0.2 4.9e-124 412.4 0.2 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 ETS65108.1 - 1.2e-37 128.9 0.0 2.4e-37 127.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS65108.1 - 2e-17 63.7 0.0 3.8e-17 62.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETS65108.1 - 6.9e-10 39.3 0.1 1.9e-09 37.8 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ETS65108.1 - 1.1e-08 34.2 0.0 1.5e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 ETS65108.1 - 9.1e-06 25.5 0.6 3.9e-05 23.5 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase SPT6_acidic PF14632.6 ETS65108.1 - 6.4 7.4 10.9 5.8 7.6 4.8 3.0 2 1 0 2 2 2 0 Acidic N-terminal SPT6 Ras PF00071.22 ETS65109.1 - 5e-31 107.5 0.0 5.6e-31 107.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS65109.1 - 5.8e-11 42.7 0.0 8.2e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 ETS65109.1 - 0.097 12.2 0.0 0.12 11.9 0.0 1.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain UQ_con PF00179.26 ETS65110.1 - 2.3e-18 66.2 0.0 3.1e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Abhydrolase_3 PF07859.13 ETS65111.1 - 4.2e-23 82.3 0.0 7.8e-23 81.4 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETS65111.1 - 0.00019 20.4 0.0 0.00029 19.8 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase DUF1168 PF06658.12 ETS65112.1 - 4.5e-41 139.9 18.0 6.4e-41 139.4 18.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1168) Vps16_C PF04840.12 ETS65113.1 - 1.2e-73 248.0 3.6 6.1e-49 166.8 2.5 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region Vps16_N PF04841.13 ETS65113.1 - 2.1e-68 231.0 0.0 4.5e-42 144.2 0.0 3.3 3 0 0 3 3 3 3 Vps16, N-terminal region WLM PF08325.10 ETS65114.1 - 3e-31 109.0 3.2 5.9e-30 104.8 3.2 2.5 1 1 0 1 1 1 1 WLM domain zf-RanBP PF00641.18 ETS65114.1 - 9.2e-06 24.9 3.2 1.7e-05 24.0 3.2 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF45 PF01863.17 ETS65114.1 - 0.015 15.4 2.0 0.021 14.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF45 DUF2509 PF10713.9 ETS65114.1 - 0.03 14.4 1.7 0.033 14.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2509) DUF3519 PF12033.8 ETS65114.1 - 0.11 12.9 0.4 0.36 11.3 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3519) GATA PF00320.27 ETS65116.1 - 5.2e-12 45.1 2.7 9.5e-12 44.3 2.7 1.4 1 0 0 1 1 1 1 GATA zinc finger Sugar_tr PF00083.24 ETS65117.1 - 4.9e-88 296.0 19.3 6.1e-88 295.6 19.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS65117.1 - 7.4e-21 74.5 19.1 7.4e-21 74.5 19.1 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily PepSY_TM PF03929.16 ETS65117.1 - 0.052 13.2 0.4 0.052 13.2 0.4 2.3 2 1 1 3 3 3 0 PepSY-associated TM region Autophagy_C PF10381.9 ETS65117.1 - 0.17 11.5 0.2 0.39 10.3 0.2 1.7 1 0 0 1 1 1 0 Autophagocytosis associated protein C-terminal GST_N PF02798.20 ETS65118.1 - 1.1e-15 57.8 0.0 3e-15 56.3 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ETS65118.1 - 3.8e-12 46.5 0.0 7.8e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETS65118.1 - 3.8e-11 43.1 0.0 7.6e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Ribosomal_L5_C PF00673.21 ETS65119.1 - 1.3e-21 76.6 0.0 2.7e-21 75.5 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ETS65119.1 - 2.1e-16 60.0 0.0 4e-16 59.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 PDZ_5 PF17817.1 ETS65120.1 - 0.027 14.7 0.1 0.073 13.4 0.1 1.6 1 0 0 1 1 1 0 PDZ domain DEAD PF00270.29 ETS65121.1 - 1e-46 158.9 0.0 2.1e-46 157.9 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS65121.1 - 3e-31 108.0 0.0 5.6e-31 107.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UTP25 PF06862.12 ETS65121.1 - 0.05 12.4 0.0 0.092 11.5 0.0 1.3 1 0 0 1 1 1 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ResIII PF04851.15 ETS65121.1 - 0.2 11.7 0.0 0.6 10.1 0.0 1.8 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ETS65121.1 - 0.27 10.4 0.0 0.43 9.7 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase AMP-binding PF00501.28 ETS65122.1 - 2.7e-33 115.2 0.2 1.6e-32 112.6 0.2 2.2 1 1 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ETS65122.1 - 3.1e-31 108.5 0.0 7.2e-31 107.3 0.0 1.6 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 ETS65122.1 - 9.2e-09 35.1 0.0 5.4e-08 32.6 0.0 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 ETS65122.1 - 1.1e-07 32.1 0.0 3.7e-07 30.4 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site KR PF08659.10 ETS65122.1 - 0.029 14.3 0.1 0.029 14.3 0.1 2.0 2 0 0 2 2 2 0 KR domain DXP_reductoisom PF02670.16 ETS65122.1 - 0.067 13.9 0.6 4.5 8.0 0.1 2.9 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Polysacc_synt_2 PF02719.15 ETS65122.1 - 0.11 11.6 0.1 0.22 10.6 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ETS65122.1 - 0.19 10.7 0.0 0.53 9.2 0.0 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 ETS65122.1 - 0.41 10.8 1.4 1.1 9.4 0.1 2.4 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus MFS_1 PF07690.16 ETS65123.1 - 1.3e-27 96.7 21.9 5.1e-27 94.7 22.8 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Aldo_ket_red PF00248.21 ETS65124.1 - 7.4e-45 153.4 0.0 9.2e-44 149.8 0.0 1.9 1 1 0 1 1 1 1 Aldo/keto reductase family Slx4 PF09494.10 ETS65124.1 - 0.00042 20.2 0.5 0.99 9.4 0.0 2.5 2 0 0 2 2 2 2 Slx4 endonuclease Fungal_trans PF04082.18 ETS65125.1 - 5.9e-20 71.4 0.1 1.3e-19 70.3 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain zf-C2H2 PF00096.26 ETS65125.1 - 0.0003 21.1 18.3 0.0047 17.3 0.3 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ETS65125.1 - 0.023 15.0 3.0 0.9 9.9 0.6 3.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ETS65125.1 - 0.065 14.1 15.9 0.17 12.8 2.4 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ETS65125.1 - 0.18 11.7 3.4 13 5.9 0.5 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Spt20 PF12090.8 ETS65125.1 - 1.9 8.0 23.6 0.17 11.5 18.6 1.7 2 0 0 2 2 2 0 Spt20 family zf-BED PF02892.15 ETS65125.1 - 2.5 8.2 5.6 0.33 11.0 1.1 1.9 2 0 0 2 2 2 0 BED zinc finger MAP65_ASE1 PF03999.12 ETS65125.1 - 5.2 5.6 18.0 8.2 5.0 18.0 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) adh_short PF00106.25 ETS65129.1 - 3.8e-25 88.5 0.6 5.7e-25 87.9 0.6 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETS65129.1 - 7.7e-18 64.9 0.2 1.1e-17 64.4 0.2 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETS65129.1 - 0.00031 20.7 0.3 0.0007 19.6 0.1 1.6 2 0 0 2 2 2 1 KR domain OmpA PF00691.20 ETS65129.1 - 0.083 13.3 0.1 0.16 12.4 0.1 1.5 1 0 0 1 1 1 0 OmpA family Nop25 PF09805.9 ETS65130.1 - 2.3e-22 80.0 14.5 2.3e-22 80.0 14.5 3.4 4 0 0 4 4 4 1 Nucleolar protein 12 (25kDa) RRM_1 PF00076.22 ETS65130.1 - 0.0031 17.3 0.0 0.016 15.0 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LPMO_10 PF03067.15 ETS65131.1 - 1.4e-33 117.2 0.6 1.4e-33 117.2 0.6 1.9 2 0 0 2 2 2 1 Lytic polysaccharide mono-oxygenase, cellulose-degrading Med3 PF11593.8 ETS65131.1 - 0.077 12.2 13.3 0.11 11.6 13.3 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Macoilin PF09726.9 ETS65131.1 - 0.8 8.2 12.3 0.96 7.9 12.3 1.1 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETS65131.1 - 1.4 7.1 8.1 1.9 6.7 8.1 1.1 1 0 0 1 1 1 0 Menin Tmemb_cc2 PF10267.9 ETS65131.1 - 3.8 6.6 6.2 4.7 6.2 6.2 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein CMD PF02627.20 ETS65132.1 - 9.8e-20 70.4 0.1 1.5e-19 69.8 0.1 1.3 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family Methyltransf_24 PF13578.6 ETS65133.1 - 6.2e-05 24.0 0.0 0.00013 22.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltrans_RNA PF04452.14 ETS65133.1 - 0.018 14.4 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase Ribosomal_60s PF00428.19 ETS65133.1 - 0.15 12.6 3.6 0.28 11.8 3.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein MFS_1 PF07690.16 ETS65134.1 - 5.5e-17 61.7 55.4 5.5e-17 61.7 55.4 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Bacillus_PapR PF05968.11 ETS65134.1 - 0.0074 16.1 0.6 0.21 11.5 0.0 2.9 2 0 0 2 2 2 1 Bacillus PapR protein TPR_12 PF13424.6 ETS65137.1 - 1e-12 48.2 19.9 0.0049 17.1 0.3 8.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETS65137.1 - 0.0025 17.7 8.7 0.8 9.9 0.2 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat AAA_16 PF13191.6 ETS65137.1 - 0.0069 16.8 0.3 0.0069 16.8 0.3 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ETS65137.1 - 0.024 14.9 0.0 0.2 12.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETS65137.1 - 0.054 14.0 0.0 0.3 11.7 0.0 2.4 1 0 0 1 1 1 0 AAA domain FIST PF08495.10 ETS65137.1 - 0.08 12.9 0.0 0.25 11.3 0.0 1.8 1 0 0 1 1 1 0 FIST N domain TPR_2 PF07719.17 ETS65137.1 - 3.9 7.8 14.8 4.1 7.7 0.3 5.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETS65137.1 - 3.9 7.5 8.5 43 4.2 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat UPF0121 PF03661.13 ETS65138.1 - 3.7e-48 164.0 7.4 4.4e-48 163.8 7.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DnaJ PF00226.31 ETS65139.1 - 0.0012 18.9 0.1 0.0026 17.9 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 ETS65139.1 - 0.23 11.6 5.8 10 6.6 0.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat JmjC PF02373.22 ETS65140.1 - 2.3e-39 134.4 0.1 4.7e-39 133.3 0.1 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 ETS65140.1 - 4.8e-14 52.0 0.0 1.1e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 jmjN domain zf-HC5HC2H_2 PF13832.6 ETS65140.1 - 2.3e-09 37.4 2.9 5.4e-09 36.2 2.9 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETS65140.1 - 3.5e-09 36.8 3.5 9.3e-09 35.4 3.5 1.8 1 0 0 1 1 1 1 PHD-like zinc-binding domain FANCL_C PF11793.8 ETS65140.1 - 0.23 11.7 1.5 0.51 10.5 1.5 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain AMP-binding PF00501.28 ETS65141.1 - 5.1e-34 117.6 0.0 6.9e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ATP-synt_J PF04911.12 ETS65142.1 - 2.7e-24 84.5 0.2 3.5e-24 84.1 0.2 1.2 1 0 0 1 1 1 1 ATP synthase j chain MFS_1 PF07690.16 ETS65143.1 - 1.4e-25 89.9 28.3 2.2e-25 89.3 27.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS65143.1 - 2.5e-08 33.2 2.5 2.5e-08 33.2 2.5 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 ETS65143.1 - 0.00045 18.9 0.7 0.00045 18.9 0.7 1.9 2 0 0 2 2 2 1 MFS/sugar transport protein SNARE_assoc PF09335.11 ETS65144.1 - 4.5e-12 46.5 2.2 4.5e-12 46.5 2.2 1.6 2 0 0 2 2 2 1 SNARE associated Golgi protein UL20 PF17582.2 ETS65144.1 - 0.056 12.7 0.3 0.096 12.0 0.0 1.4 2 0 0 2 2 2 0 Cytomegalovirus UL20 Cation_ATPase_C PF00689.21 ETS65144.1 - 0.77 9.4 4.9 5.3 6.7 4.9 2.0 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus Proteasome PF00227.26 ETS65145.1 - 7.5e-59 198.4 0.3 9.9e-59 198.0 0.3 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ETS65145.1 - 3.4e-14 52.2 0.3 1e-13 50.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Peptidase_M55 PF04951.13 ETS65145.1 - 0.0087 15.5 0.1 0.014 14.8 0.1 1.3 1 0 0 1 1 1 1 D-aminopeptidase Ion_trans PF00520.31 ETS65146.1 - 2.5e-122 406.8 71.4 3.5e-38 131.2 5.2 5.1 5 0 0 5 5 5 5 Ion transport protein PKD_channel PF08016.12 ETS65146.1 - 0.00086 18.1 8.5 0.00086 18.1 8.5 7.3 7 2 1 8 8 8 4 Polycystin cation channel HAD_2 PF13419.6 ETS65147.1 - 3.9e-10 40.1 0.0 6.5e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETS65147.1 - 1.8e-06 28.4 0.0 1.1e-05 25.9 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS65147.1 - 8.1e-05 22.6 0.0 0.00015 21.8 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like COX4 PF02936.14 ETS65148.1 - 1.3e-35 122.4 0.1 2.3e-35 121.6 0.1 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV HMG_box_2 PF09011.10 ETS65148.1 - 0.25 11.9 3.5 3.2 8.4 0.1 2.6 1 1 1 2 2 2 0 HMG-box domain SH3BGR PF04908.15 ETS65149.1 - 2.5e-08 34.0 0.0 8.3e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein PUF PF00806.19 ETS65150.1 - 1.8e-17 62.0 0.0 0.00015 21.3 0.0 5.2 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat MyTH4 PF00784.17 ETS65150.1 - 0.042 14.3 0.1 0.11 13.1 0.1 1.7 1 0 0 1 1 1 0 MyTH4 domain Ornatin PF02088.15 ETS65150.1 - 0.16 11.8 0.1 0.37 10.6 0.1 1.5 1 0 0 1 1 1 0 Ornatin RNase_PH PF01138.21 ETS65151.1 - 5.1e-21 75.6 0.1 1.1e-20 74.5 0.1 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ETS65151.1 - 0.024 14.6 0.0 0.084 12.9 0.0 2.1 2 1 0 2 2 2 0 3' exoribonuclease family, domain 2 COG7 PF10191.9 ETS65152.1 - 5.8e-36 124.0 12.8 1.5e-33 116.1 10.9 2.3 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) Exo84_C PF16528.5 ETS65152.1 - 0.0081 16.0 0.2 0.021 14.6 0.2 1.7 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Med9 PF07544.13 ETS65152.1 - 0.52 10.4 1.9 3.7 7.7 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 CDC37_N PF03234.14 ETS65153.1 - 2e-39 135.5 1.1 2e-39 135.5 1.1 2.8 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 ETS65153.1 - 7.1e-24 84.0 0.0 1.3e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 ETS65153.1 - 3.5e-20 72.0 0.2 1.1e-19 70.4 0.2 1.9 1 0 0 1 1 1 1 Cdc37 C terminal domain Fe-S_biosyn PF01521.20 ETS65153.1 - 2e-13 50.5 0.0 5.2e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis NAC PF01849.18 ETS65154.1 - 5.2e-20 71.2 0.0 1.2e-19 70.1 0.0 1.6 1 0 0 1 1 1 1 NAC domain Spore_coat_CotO PF14153.6 ETS65154.1 - 0.35 10.8 5.1 0.58 10.1 5.1 1.3 1 0 0 1 1 1 0 Spore coat protein CotO CSRNP_N PF16019.5 ETS65154.1 - 1.3 8.9 4.2 1.8 8.4 1.3 1.9 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus MRNIP PF15749.5 ETS65154.1 - 1.4 9.6 4.9 5 7.9 2.2 2.2 2 0 0 2 2 2 0 MRN-interacting protein YbaB_DNA_bd PF02575.16 ETS65154.1 - 2.6 8.3 12.9 0.99 9.7 10.0 1.8 2 0 0 2 2 2 0 YbaB/EbfC DNA-binding family PGA2 PF07543.12 ETS65154.1 - 4.4 7.3 9.3 1.1 9.3 4.5 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF3955 PF13127.6 ETS65155.1 - 0.0001 22.1 1.0 0.00041 20.1 1.0 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3955) FA_desaturase PF00487.24 ETS65155.1 - 0.063 13.1 0.2 0.36 10.6 0.0 2.3 2 0 0 2 2 2 0 Fatty acid desaturase EamA PF00892.20 ETS65155.1 - 1.3 9.2 30.0 0.65 10.2 6.0 3.2 3 0 0 3 3 3 0 EamA-like transporter family PMT PF02366.18 ETS65156.1 - 8e-75 251.6 17.5 1.4e-74 250.8 17.5 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ETS65156.1 - 3.1e-57 193.4 13.0 6.9e-57 192.3 13.0 1.6 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ETS65156.1 - 1.6e-24 86.8 0.3 2.8e-24 86.0 0.3 1.3 1 0 0 1 1 1 1 MIR domain GET2 PF08690.10 ETS65157.1 - 7.7e-17 61.9 2.7 6.1e-08 32.7 0.2 2.7 2 1 0 2 2 2 2 GET complex subunit GET2 Hid1 PF12722.7 ETS65158.1 - 1.9e-141 472.9 0.0 1.4e-140 470.0 0.0 2.2 1 1 0 1 1 1 1 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ETS65158.1 - 2.1e-75 254.4 0.0 3.2e-75 253.8 0.0 1.3 1 1 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein BSD PF03909.17 ETS65159.1 - 5.6e-21 74.3 0.0 3.4e-15 55.8 0.0 2.6 2 0 0 2 2 2 2 BSD domain PH_TFIIH PF08567.11 ETS65159.1 - 1.2e-15 57.6 0.3 3.3e-15 56.2 0.1 1.9 2 0 0 2 2 2 1 TFIIH p62 subunit, N-terminal domain RNAse_A_bac PF18431.1 ETS65159.1 - 0.26 12.3 1.8 0.57 11.2 0.1 2.5 2 1 0 2 2 2 0 Bacterial CdiA-CT RNAse A domain Mucin PF01456.17 ETS65159.1 - 1.6 8.7 16.7 0.24 11.4 9.1 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein ORC6 PF05460.13 ETS65159.1 - 1.7 7.8 7.9 1.5 8.0 5.9 1.9 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) DSPc PF00782.20 ETS65160.1 - 1.4e-07 31.4 0.0 4.5e-07 29.8 0.0 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 ETS65160.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 ETS65160.1 - 0.018 14.6 0.0 0.16 11.5 0.0 2.1 2 0 0 2 2 2 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETS65160.1 - 0.022 14.9 0.0 0.061 13.4 0.0 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate zf-C3HC4_3 PF13920.6 ETS65161.1 - 2.5e-07 30.5 6.3 2.5e-07 30.5 6.3 3.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETS65161.1 - 0.0045 16.8 9.8 0.0045 16.8 9.8 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETS65161.1 - 1.6 8.7 17.8 0.048 13.5 8.8 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2 PF00096.26 ETS65161.1 - 2.2 8.9 15.0 1.9 9.1 0.2 4.8 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-RING_2 PF13639.6 ETS65161.1 - 5.2 7.5 15.4 0.4 11.1 8.4 2.6 3 0 0 3 3 3 0 Ring finger domain DEAD PF00270.29 ETS65162.1 - 3e-45 154.1 0.4 5.1e-45 153.4 0.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETS65162.1 - 2.9e-29 101.7 0.2 4.7e-28 97.7 0.1 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETS65162.1 - 1.2e-05 25.4 0.0 2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETS65162.1 - 0.00079 19.8 0.1 0.0042 17.4 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETS65162.1 - 0.0015 18.3 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 ETS65162.1 - 0.019 14.3 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_RecD PF05127.14 ETS65162.1 - 0.065 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Helicase Zn_clus PF00172.18 ETS65163.1 - 2.3e-09 37.2 8.0 4.1e-09 36.4 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dabb PF07876.12 ETS65164.1 - 9.7e-15 55.0 0.0 1.1e-14 54.8 0.0 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain SNF2_N PF00176.23 ETS65165.1 - 7e-55 186.1 0.0 1.2e-54 185.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETS65165.1 - 2e-18 66.7 0.0 1.3e-17 64.1 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HSA PF07529.13 ETS65165.1 - 1.5e-12 47.6 10.4 1.5e-12 47.6 10.4 2.9 3 0 0 3 3 3 1 HSA ResIII PF04851.15 ETS65165.1 - 4.9e-07 29.9 0.0 1.3e-06 28.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DBINO PF13892.6 ETS65165.1 - 0.58 10.5 12.4 2.7 8.4 12.4 2.2 1 0 0 1 1 1 0 DNA-binding domain HLH PF00010.26 ETS65166.1 - 4.4e-12 45.8 0.0 1.2e-11 44.4 0.0 1.8 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain AMP-binding_C PF13193.6 ETS65166.1 - 1.6e-05 25.7 0.0 8.8e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain TFIIA PF03153.13 ETS65166.1 - 0.00079 19.5 1.2 0.00096 19.3 1.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF4611 PF15387.6 ETS65166.1 - 3.5 7.9 11.7 4.9 7.4 9.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 ETS65166.1 - 6.9 4.6 9.5 9.5 4.2 9.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Tom22 PF04281.13 ETS65166.1 - 9.3 6.0 10.1 9.8 6.0 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 DUF423 PF04241.15 ETS65167.1 - 4.4e-24 84.5 2.3 7e-24 83.9 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF423) DUF2627 PF11118.8 ETS65167.1 - 0.051 14.2 2.2 0.79 10.3 2.2 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2627) Gram_pos_anchor PF00746.21 ETS65167.1 - 0.76 9.8 11.3 0.93 9.5 0.0 3.1 3 0 0 3 3 3 0 LPXTG cell wall anchor motif Tyrosinase PF00264.20 ETS65168.1 - 4.3e-20 72.9 5.8 7.8e-20 72.1 5.8 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Amelogenin PF02948.15 ETS65168.1 - 0.93 10.1 7.4 2.4 8.8 1.4 2.6 2 0 0 2 2 2 0 Amelogenin DUF866 PF05907.13 ETS65169.1 - 2e-53 180.5 0.2 2.2e-53 180.3 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Cytochrome_C7 PF14522.6 ETS65169.1 - 0.0049 16.8 2.0 0.0075 16.2 2.0 1.3 1 0 0 1 1 1 1 Cytochrome c7 and related cytochrome c Cytochrom_c3_2 PF14537.6 ETS65169.1 - 0.088 13.3 0.7 0.088 13.3 0.7 2.1 1 1 1 2 2 2 0 Cytochrome c3 Sec15 PF04091.12 ETS65170.1 - 4.4e-90 302.3 0.0 8.2e-90 301.4 0.0 1.5 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Sec8_exocyst PF04048.14 ETS65170.1 - 0.0001 22.2 0.8 0.00035 20.5 0.2 2.3 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain COG5 PF10392.9 ETS65170.1 - 0.00061 20.0 1.2 0.0025 18.0 0.2 2.6 2 1 0 2 2 2 1 Golgi transport complex subunit 5 Vps51 PF08700.11 ETS65170.1 - 0.0041 17.2 0.0 0.018 15.1 0.0 2.2 1 0 0 1 1 1 1 Vps51/Vps67 Seryl_tRNA_N PF02403.22 ETS65170.1 - 0.33 11.2 2.4 1.1 9.5 0.1 2.8 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 ETS65170.1 - 1.5 8.9 5.3 1 9.5 0.5 2.8 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DPBB_1 PF03330.18 ETS65171.1 - 3.1e-05 24.2 0.0 0.00011 22.4 0.0 2.0 1 1 0 1 1 1 1 Lytic transglycolase TFIIA PF03153.13 ETS65171.1 - 0.0081 16.2 31.5 0.011 15.8 31.5 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Barwin PF00967.17 ETS65171.1 - 0.11 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Barwin family Totivirus_coat PF05518.11 ETS65171.1 - 0.28 9.2 8.4 0.4 8.7 8.4 1.1 1 0 0 1 1 1 0 Totivirus coat protein SOG2 PF10428.9 ETS65171.1 - 0.34 10.0 11.9 0.4 9.8 11.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 ETS65171.1 - 1 8.1 9.2 1.2 7.9 9.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain GREB1 PF15782.5 ETS65171.1 - 1.7 5.7 13.0 1.9 5.5 13.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 ETS65171.1 - 2.4 7.1 10.1 3.1 6.7 10.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Plasmodium_Vir PF05795.11 ETS65171.1 - 2.7 7.3 9.9 3.6 6.9 9.9 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Nucleo_P87 PF07267.11 ETS65171.1 - 5.7 5.7 14.3 8.1 5.2 14.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Cys_Met_Meta_PP PF01053.20 ETS65172.1 - 5.7e-121 403.6 0.0 7.7e-121 403.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme GHMP_kinases_N PF00288.26 ETS65172.1 - 6e-16 58.4 4.4 1.3e-15 57.4 3.5 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ETS65172.1 - 9.8e-08 32.3 1.0 4.1e-07 30.3 0.2 2.3 1 1 1 2 2 2 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 ETS65172.1 - 0.0037 16.8 0.2 0.01 15.4 0.2 1.7 1 0 0 1 1 1 1 Galactokinase galactose-binding signature NTF2 PF02136.20 ETS65173.1 - 1.7e-08 35.1 0.1 4.1e-07 30.6 0.0 2.5 3 0 0 3 3 3 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 ETS65173.1 - 1.5e-07 31.5 0.0 2.3e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 RNR_inhib PF08591.10 ETS65174.1 - 0.085 14.2 1.8 0.22 12.9 1.8 1.9 1 1 0 1 1 1 0 Ribonucleotide reductase inhibitor Auts2 PF15336.6 ETS65174.1 - 0.34 11.0 6.9 0.07 13.3 2.7 1.8 1 1 1 2 2 2 0 Autism susceptibility gene 2 protein Oxysterol_BP PF01237.18 ETS65175.1 - 1.5e-90 303.7 0.3 2e-88 296.8 0.3 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Phage_stabilise PF11134.8 ETS65175.1 - 0.032 13.1 0.0 0.046 12.6 0.0 1.1 1 0 0 1 1 1 0 Phage stabilisation protein DUF1676 PF07898.13 ETS65176.1 - 0.039 14.0 4.0 0.08 13.0 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) ATP-synt_B PF00430.18 ETS65176.1 - 3.8 7.6 12.0 8.5 6.5 12.0 1.5 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) TPR_1 PF00515.28 ETS65177.1 - 1.8e-56 185.8 27.2 3.7e-08 32.9 0.1 10.9 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETS65177.1 - 8.8e-52 169.1 22.0 4.8e-06 26.3 0.1 10.8 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 ETS65177.1 - 4.8e-39 129.3 17.2 1.7e-05 24.7 0.0 10.8 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETS65177.1 - 2.1e-28 96.6 19.2 0.00023 21.3 0.4 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETS65177.1 - 1.9e-26 90.1 4.8 0.019 15.0 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETS65177.1 - 7e-26 88.7 20.3 0.00035 21.1 0.0 9.7 4 2 6 10 10 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 ETS65177.1 - 1.3e-24 86.2 15.8 2.1e-05 24.7 0.1 7.6 3 3 4 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 ETS65177.1 - 1.5e-23 83.1 22.6 3.4e-06 27.5 0.2 6.8 5 1 1 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETS65177.1 - 2.2e-23 81.3 11.5 0.0067 17.0 0.0 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETS65177.1 - 3.1e-23 81.2 30.8 1.5e-06 27.8 1.6 9.9 4 2 5 9 9 9 5 TPR repeat TPR_16 PF13432.6 ETS65177.1 - 5.1e-22 78.2 42.2 1.2e-05 25.8 0.6 9.5 6 3 2 9 9 9 6 Tetratricopeptide repeat TPR_9 PF13371.6 ETS65177.1 - 5.4e-19 68.1 9.6 0.0052 16.9 0.9 5.9 2 2 3 6 6 6 6 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS65177.1 - 1e-11 44.8 7.2 3.8e-07 30.2 1.8 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ETS65177.1 - 1.1e-09 38.0 10.1 0.0034 16.6 1.3 5.5 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_21 PF09976.9 ETS65177.1 - 2.7e-05 24.0 3.3 3 7.5 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat-like domain TPR_10 PF13374.6 ETS65177.1 - 0.00078 19.2 16.1 2.6 8.0 0.0 7.5 7 0 0 7 7 7 1 Tetratricopeptide repeat DUF4919 PF16266.5 ETS65177.1 - 0.0015 18.6 0.2 0.22 11.4 0.0 2.6 2 1 1 3 3 3 1 Domain of unknown function (DUF4919) BTAD PF03704.17 ETS65177.1 - 0.0022 18.4 5.6 4.2 7.8 0.1 3.9 3 1 0 3 3 3 1 Bacterial transcriptional activator domain DUF2225 PF09986.9 ETS65177.1 - 0.0059 16.4 3.7 0.46 10.2 1.8 2.6 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) ChAPs PF09295.10 ETS65177.1 - 0.0091 15.0 1.3 0.92 8.4 0.2 2.8 2 1 0 3 3 3 1 ChAPs (Chs5p-Arf1p-binding proteins) TOM20_plant PF06552.12 ETS65177.1 - 0.014 15.2 1.2 8.5 6.1 0.7 3.7 3 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_20 PF14561.6 ETS65177.1 - 0.058 13.7 0.1 0.058 13.7 0.1 4.1 6 1 1 7 7 3 0 Tetratricopeptide repeat Rapsyn_N PF10579.9 ETS65177.1 - 0.1 12.7 0.4 5.9 7.1 0.0 3.3 3 1 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region SNAP PF14938.6 ETS65177.1 - 0.13 11.6 15.4 3.2 7.1 0.2 4.8 2 1 1 4 4 4 0 Soluble NSF attachment protein, SNAP Fis1_TPR_C PF14853.6 ETS65177.1 - 0.61 10.2 13.1 31 4.7 0.0 6.1 5 2 2 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat DUF5344 PF17279.2 ETS65177.1 - 1.2 9.7 4.7 16 6.1 0.1 4.0 5 0 0 5 5 5 0 Family of unknown function (DUF5344) adh_short_C2 PF13561.6 ETS65178.1 - 5.1e-49 166.9 0.0 6.6e-49 166.6 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETS65178.1 - 3.9e-44 150.5 0.0 4.7e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETS65178.1 - 2.1e-07 31.0 0.0 3.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF4523 PF15023.6 ETS65178.1 - 0.15 11.9 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) TPT PF03151.16 ETS65179.1 - 3.5e-20 72.5 17.8 4.4e-20 72.2 17.8 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ETS65179.1 - 1.6e-08 34.8 30.2 4.2e-05 23.7 11.3 2.3 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ETS65179.1 - 0.73 9.0 20.5 0.19 10.9 14.9 2.2 1 1 1 2 2 2 0 UAA transporter family eIF3_subunit PF08597.10 ETS65179.1 - 0.84 9.5 7.4 1.6 8.6 7.4 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Med31 PF05669.12 ETS65180.1 - 7.5e-32 109.2 0.3 9.1e-32 108.9 0.3 1.1 1 0 0 1 1 1 1 SOH1 GSH_synth_ATP PF03917.17 ETS65181.1 - 5.1e-131 436.9 0.0 5.8e-131 436.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 ETS65181.1 - 1.4e-32 112.2 0.0 2.5e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Peptidase_M85 PF13678.6 ETS65181.1 - 0.02 14.5 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 NFkB-p65-degrading zinc protease V-ATPase_H_N PF03224.14 ETS65182.1 - 2.7e-106 355.5 0.0 4.5e-106 354.7 0.0 1.4 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 ETS65182.1 - 2.7e-38 130.7 0.0 6.8e-38 129.4 0.0 1.7 1 0 0 1 1 1 1 V-ATPase subunit H Arm PF00514.23 ETS65182.1 - 5.3e-05 23.1 5.4 0.059 13.4 0.1 4.7 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 ETS65182.1 - 0.12 10.9 0.1 3.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Adaptin N terminal region Sporozoite_P67 PF05642.11 ETS65182.1 - 0.43 8.6 3.8 0.8 7.7 3.8 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MRP-L46 PF11788.8 ETS65183.1 - 1e-25 90.8 0.4 2e-25 89.9 0.4 1.5 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 GTP_EFTU PF00009.27 ETS65183.1 - 2.9e-20 72.6 0.0 6.7e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ETS65183.1 - 6.6e-06 26.4 0.7 1.8e-05 25.0 0.7 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETS65183.1 - 0.029 14.4 0.0 0.082 13.0 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 ETS65183.1 - 0.18 11.7 1.1 3.6 7.5 0.1 2.5 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Nop52 PF05997.12 ETS65184.1 - 2.9e-76 256.1 0.0 4.8e-76 255.3 0.0 1.4 1 0 0 1 1 1 1 Nucleolar protein,Nop52 ATP13 PF12921.7 ETS65184.1 - 0.067 13.1 0.0 0.37 10.7 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ATPase expression DUF4050 PF13259.6 ETS65184.1 - 2.7 8.3 0.0 2.7 8.3 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4050) BUD22 PF09073.10 ETS65184.1 - 8.4 5.6 26.1 0.24 10.7 19.8 1.6 2 0 0 2 2 2 0 BUD22 SAPS PF04499.15 ETS65184.1 - 8.9 5.0 8.5 13 4.5 8.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Actin PF00022.19 ETS65185.1 - 4.2e-53 180.4 0.0 1e-25 90.2 0.0 2.4 2 0 0 2 2 2 2 Actin ATG16 PF08614.11 ETS65186.1 - 1.2e-56 192.1 20.5 1.7e-56 191.6 20.5 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DASH_Dam1 PF08653.10 ETS65186.1 - 0.13 12.1 1.7 6.5 6.6 0.3 2.9 2 0 0 2 2 2 0 DASH complex subunit Dam1 XLF PF09302.11 ETS65186.1 - 0.16 12.1 5.3 0.057 13.6 2.1 1.9 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF4407 PF14362.6 ETS65186.1 - 0.29 10.4 14.3 0.48 9.7 14.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ETS65186.1 - 0.38 10.9 10.9 0.14 12.4 6.7 2.1 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 ETS65186.1 - 0.52 10.8 6.0 1.7 9.1 0.2 3.2 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 ETS65186.1 - 2.2 8.7 24.7 1.4 9.3 3.4 3.1 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Macoilin PF09726.9 ETS65186.1 - 2.3 6.7 10.6 2.9 6.4 10.6 1.0 1 0 0 1 1 1 0 Macoilin family UPF0242 PF06785.11 ETS65186.1 - 2.7 8.0 16.4 78 3.3 16.4 2.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 ETS65186.1 - 3.3 8.4 26.7 4.2 8.1 0.3 4.5 2 1 2 4 4 4 0 SlyX YabA PF06156.13 ETS65186.1 - 4.8 7.9 16.6 0.41 11.3 1.7 3.3 2 1 1 3 3 3 0 Initiation control protein YabA TMF_TATA_bd PF12325.8 ETS65186.1 - 6.1 7.1 23.3 1.1 9.5 7.5 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Ras PF00071.22 ETS65187.1 - 1.1e-56 190.9 0.0 1.3e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETS65187.1 - 1.1e-30 106.3 0.0 1.7e-30 105.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETS65187.1 - 2.8e-12 46.4 0.0 3.2e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETS65187.1 - 3.3e-07 30.4 0.0 6.1e-07 29.5 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETS65187.1 - 0.00011 21.6 0.0 0.00018 20.9 0.0 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ETS65187.1 - 0.00017 21.6 0.2 0.0042 17.0 0.1 2.3 1 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ETS65187.1 - 0.00029 20.4 0.0 0.011 15.3 0.0 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.9 ETS65187.1 - 0.0026 17.5 0.0 0.23 11.2 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 ETS65187.1 - 0.0062 15.9 0.1 0.076 12.3 0.0 2.2 2 0 0 2 2 2 1 Septin cobW PF02492.19 ETS65187.1 - 0.0074 15.9 0.0 0.021 14.4 0.0 1.7 1 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 ETS65187.1 - 0.0081 16.6 0.1 0.02 15.3 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain ATP_bind_1 PF03029.17 ETS65187.1 - 0.011 15.5 0.3 0.47 10.2 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ETS65187.1 - 0.012 15.9 0.0 0.026 14.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETS65187.1 - 0.016 14.9 0.0 0.042 13.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain SRPRB PF09439.10 ETS65187.1 - 0.024 14.1 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ETS65187.1 - 0.035 13.6 0.0 0.056 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 ETS65187.1 - 0.036 14.1 0.0 0.075 13.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATPase_2 PF01637.18 ETS65187.1 - 0.053 13.4 0.3 0.099 12.5 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Glyco_hydro_75 PF07335.11 ETS65187.1 - 0.1 12.9 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 NACHT PF05729.12 ETS65187.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 NACHT domain TniB PF05621.11 ETS65187.1 - 0.16 11.3 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein MFAP1 PF06991.11 ETS65188.1 - 3.1e-62 210.3 20.2 3.1e-62 210.3 20.2 2.9 2 1 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing Far-17a_AIG1 PF04750.14 ETS65189.1 - 1.2e-06 28.0 10.4 1.2e-06 28.0 10.4 1.7 2 0 0 2 2 2 1 FAR-17a/AIG1-like protein Zn_clus PF00172.18 ETS65190.1 - 7.7e-05 22.7 8.9 0.00014 21.9 8.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain GATA PF00320.27 ETS65191.1 - 1.9e-06 27.3 2.7 3.3e-06 26.6 2.7 1.4 1 0 0 1 1 1 1 GATA zinc finger Ntox28 PF15605.6 ETS65191.1 - 0.1 12.8 0.1 0.24 11.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial toxin 28 LsmAD PF06741.13 ETS65191.1 - 1.4 9.5 5.0 0.36 11.4 1.1 2.0 2 0 0 2 2 2 0 LsmAD domain Vma12 PF11712.8 ETS65193.1 - 2.6e-32 111.8 0.2 4.7e-32 111.0 0.2 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF89 PF01937.19 ETS65194.1 - 1.3e-111 373.0 0.0 2.2e-79 267.0 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function DUF89 NTS_2 PF15448.6 ETS65194.1 - 0.16 12.3 0.2 0.38 11.2 0.2 1.6 1 0 0 1 1 1 0 N-terminal segments of P. falciparum erythrocyte membrane protein HSCB_C PF07743.13 ETS65195.1 - 1.7e-18 66.8 5.2 3e-18 66.1 5.2 1.4 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 ETS65195.1 - 3.2e-05 24.0 0.0 6.5e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 DnaJ domain DZR PF12773.7 ETS65195.1 - 0.027 14.5 0.4 0.046 13.8 0.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon cwf21 PF08312.12 ETS65195.1 - 0.11 12.6 2.3 0.24 11.6 2.3 1.4 1 0 0 1 1 1 0 cwf21 domain SGTA_dimer PF16546.5 ETS65195.1 - 0.14 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 Homodimerisation domain of SGTA zf-ribbon_3 PF13248.6 ETS65195.1 - 0.27 10.7 6.2 4.3 6.9 6.5 2.2 1 1 1 2 2 2 0 zinc-ribbon domain zf_C2H2_10 PF18414.1 ETS65195.1 - 6.6 6.4 5.3 27 4.4 0.3 2.7 2 0 0 2 2 2 0 C2H2 type zinc-finger DUF3185 PF11381.8 ETS65196.1 - 0.05 13.6 0.0 0.083 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) Ribosomal_L16 PF00252.18 ETS65197.1 - 1.8e-41 141.2 0.1 2.3e-41 140.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Sec20 PF03908.13 ETS65198.1 - 1.3e-16 60.3 1.7 1.3e-16 60.3 1.7 2.6 3 0 0 3 3 3 1 Sec20 FAA_hydrolase_N PF09298.11 ETS65198.1 - 1.7 8.9 6.2 0.95 9.7 0.6 2.9 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal EamA PF00892.20 ETS65199.1 - 3.9e-07 30.3 7.3 3.9e-07 30.3 7.3 3.7 4 0 0 4 4 4 2 EamA-like transporter family CSG2 PF16965.5 ETS65199.1 - 0.0005 19.1 0.0 0.00092 18.3 0.0 1.4 1 0 0 1 1 1 1 Ceramide synthase regulator PetN PF03742.14 ETS65199.1 - 3.2 7.7 6.7 2.5 8.0 0.8 2.9 2 0 0 2 2 2 0 PetN Glyco_hydro_cc PF11790.8 ETS65200.1 - 1.5e-61 208.0 6.1 1.9e-61 207.7 6.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Glyco_hydro_39 PF01229.17 ETS65200.1 - 0.002 16.8 0.1 0.021 13.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 39 DUF3824 PF12868.7 ETS65200.1 - 0.92 10.2 5.5 13 6.4 1.1 2.3 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Slx4 PF09494.10 ETS65201.1 - 2.1e-14 53.2 0.0 4e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Slx4 endonuclease HoxA13_N PF12284.8 ETS65201.1 - 6.4 7.4 9.1 6.1 7.5 4.2 2.8 3 0 0 3 3 3 0 Hox protein A13 N terminal Y_phosphatase2 PF03162.13 ETS65202.1 - 2.3e-41 141.1 0.0 1.3e-40 138.7 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family SelP_N PF04592.14 ETS65202.1 - 5 6.5 10.7 7.4 5.9 10.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region aGPT-Pplase1 PF18723.1 ETS65203.1 - 2.7e-90 302.6 0.0 8e-90 301.1 0.0 1.6 2 0 0 2 2 2 1 alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 1 Chromo PF00385.24 ETS65203.1 - 1.8e-05 24.6 0.0 3.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RF-1 PF00472.20 ETS65204.1 - 1.8e-20 73.0 4.4 3.3e-20 72.1 4.4 1.4 1 0 0 1 1 1 1 RF-1 domain Aminotran_5 PF00266.19 ETS65205.1 - 1e-33 116.9 0.0 4.9e-33 114.6 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V Med7 PF05983.11 ETS65206.1 - 1.3e-50 172.1 1.1 3e-50 171.0 1.1 1.6 1 0 0 1 1 1 1 MED7 protein Sel1 PF08238.12 ETS65206.1 - 1.3e-09 38.4 17.5 7.8e-05 23.2 0.2 4.2 4 0 0 4 4 4 3 Sel1 repeat RNA_POL_M_15KD PF02150.16 ETS65207.1 - 1e-12 47.7 2.6 1e-12 47.7 2.6 3.3 4 0 0 4 4 4 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 ETS65207.1 - 1.9e-11 43.6 4.1 1.1e-09 37.9 0.0 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 ETS65207.1 - 0.00043 20.3 4.7 4.3 7.5 0.0 3.8 4 0 0 4 4 4 2 Zinc ribbon domain CpXC PF14353.6 ETS65207.1 - 0.0071 16.4 5.3 2.4 8.3 0.8 3.3 1 1 2 3 3 3 1 CpXC protein TackOD1 PF18551.1 ETS65207.1 - 0.0093 15.6 4.3 0.072 12.7 0.2 2.5 2 1 0 2 2 2 1 Thaumarchaeal output domain 1 DZR PF12773.7 ETS65207.1 - 0.012 15.7 8.1 0.061 13.4 0.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf-TFIIB PF13453.6 ETS65207.1 - 0.026 13.9 4.7 0.86 9.0 0.3 2.4 2 0 0 2 2 2 0 Transcription factor zinc-finger DUF2197 PF09963.9 ETS65207.1 - 0.033 14.4 1.3 0.033 14.4 1.3 3.0 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2197) DUF3268 PF11672.8 ETS65207.1 - 0.078 13.3 1.3 2.4 8.5 0.0 2.3 2 0 0 2 2 2 0 zinc-finger-containing domain Zn_Tnp_IS1595 PF12760.7 ETS65207.1 - 0.091 12.8 7.4 2.6 8.1 0.6 2.6 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Elf1 PF05129.13 ETS65207.1 - 0.37 10.9 4.6 10 6.3 0.5 2.5 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_12 PF11331.8 ETS65207.1 - 0.48 10.3 7.7 12 5.9 0.1 3.9 4 0 0 4 4 4 0 Probable zinc-ribbon domain Zn_ribbon_recom PF13408.6 ETS65207.1 - 0.57 10.8 5.5 1 10.0 0.2 2.5 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Lar_restr_allev PF14354.6 ETS65207.1 - 0.62 10.5 8.4 0.15 12.5 0.6 2.9 2 2 0 2 2 2 0 Restriction alleviation protein Lar Rpr2 PF04032.16 ETS65207.1 - 0.68 10.2 5.8 10 6.5 5.8 2.6 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf_UBZ PF18439.1 ETS65207.1 - 0.91 9.2 9.9 4.4 7.0 0.1 3.7 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger HypA PF01155.19 ETS65207.1 - 1.1 9.3 4.3 0.53 10.3 1.1 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DNA_RNApol_7kD PF03604.13 ETS65207.1 - 1.7 8.4 9.6 13 5.5 0.1 3.9 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit zf-IS66 PF13005.7 ETS65207.1 - 4.9 7.6 9.2 24 5.4 0.1 3.9 3 1 1 4 4 4 0 zinc-finger binding domain of transposase IS66 TF_Zn_Ribbon PF08271.12 ETS65207.1 - 6 6.5 8.3 9 5.9 1.9 3.5 3 1 1 4 4 4 0 TFIIB zinc-binding zf_C2H2_ZHX PF18387.1 ETS65207.1 - 6.3 6.5 7.5 19 5.0 0.1 3.2 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zinc_ribbon_9 PF14369.6 ETS65207.1 - 7.9 6.8 10.8 5.6 7.3 0.3 2.9 3 0 0 3 3 3 0 zinc-ribbon Aminotran_4 PF01063.19 ETS65208.1 - 6.5e-30 104.6 0.0 2.2e-29 102.9 0.0 1.9 1 1 0 1 1 1 1 Amino-transferase class IV Proteasome PF00227.26 ETS65209.1 - 1.2e-50 171.6 0.1 1.5e-50 171.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 ETS65209.1 - 9.8e-10 37.7 0.1 9.8e-10 37.7 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal DUF4116 PF13475.6 ETS65209.1 - 0.048 13.4 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) DUF4520 PF15016.6 ETS65209.1 - 0.16 12.0 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) PAC2 PF09754.9 ETS65210.1 - 5.7e-24 85.3 0.0 6.7e-24 85.1 0.0 1.1 1 0 0 1 1 1 1 PAC2 family EF-hand_4 PF12763.7 ETS65211.1 - 1.7e-37 127.5 0.0 5e-15 55.3 0.0 3.3 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 ETS65211.1 - 5.3e-06 26.8 0.0 0.23 11.9 0.0 4.2 5 0 0 5 5 3 1 EF-hand domain pair UBA PF00627.31 ETS65211.1 - 2.2e-05 24.2 0.0 9.2e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain EF-hand_6 PF13405.6 ETS65211.1 - 0.00046 19.9 2.0 14 6.0 0.0 5.7 6 0 0 6 6 6 0 EF-hand domain zf-C4H2 PF10146.9 ETS65211.1 - 0.002 18.5 6.6 0.0075 16.6 6.6 2.0 1 0 0 1 1 1 1 Zinc finger-containing protein EF-hand_1 PF00036.32 ETS65211.1 - 0.0036 16.7 0.0 3.2 7.5 0.0 4.6 5 0 0 5 5 5 1 EF hand UBA_3 PF09288.10 ETS65211.1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Macoilin PF09726.9 ETS65211.1 - 0.027 13.0 14.4 0.041 12.4 14.4 1.1 1 0 0 1 1 1 0 Macoilin family ATG16 PF08614.11 ETS65211.1 - 0.059 13.6 30.2 0.081 13.1 28.0 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ETS65211.1 - 0.11 11.4 27.5 0.055 12.4 24.5 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein MAD PF05557.13 ETS65211.1 - 0.22 9.9 21.3 0.3 9.4 21.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Allexi_40kDa PF05549.11 ETS65211.1 - 0.66 9.4 6.1 1.3 8.5 6.1 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein CtIP_N PF10482.9 ETS65211.1 - 0.75 9.8 14.7 1.8 8.7 14.7 1.6 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain AAA_13 PF13166.6 ETS65211.1 - 1.2 7.6 13.6 1.8 7.1 13.6 1.1 1 0 0 1 1 1 0 AAA domain DUF4201 PF13870.6 ETS65211.1 - 1.3 8.7 21.2 3.3 7.4 20.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Atg14 PF10186.9 ETS65211.1 - 1.7 7.6 24.0 0.21 10.6 17.1 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2730 PF10805.8 ETS65211.1 - 3.5 7.8 13.5 5.8 7.1 6.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) ADIP PF11559.8 ETS65211.1 - 3.9 7.5 25.8 1.3 9.1 17.2 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 ETS65211.1 - 4.6 6.5 26.2 4 6.7 23.5 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Synaptobrevin PF00957.21 ETS65211.1 - 9.2 6.1 5.8 16 5.4 5.8 1.3 1 0 0 1 1 1 0 Synaptobrevin Fez1 PF06818.15 ETS65211.1 - 9.6 6.6 25.0 18 5.7 24.9 1.4 1 1 0 1 1 1 0 Fez1 Cofac_haem_bdg PF04187.13 ETS65212.1 - 4.9e-30 105.1 0.0 1.6e-29 103.4 0.0 1.8 1 1 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN DPBB_1 PF03330.18 ETS65213.1 - 0.062 13.6 0.1 0.24 11.7 0.1 2.0 1 1 0 1 1 1 0 Lytic transglycolase WW PF00397.26 ETS65214.1 - 1.9e-09 37.4 2.4 6.9e-05 22.8 3.0 2.5 2 0 0 2 2 2 2 WW domain Pkinase PF00069.25 ETS65216.1 - 4.5e-70 236.0 0.0 6e-70 235.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65216.1 - 9.3e-49 166.0 0.0 1.3e-48 165.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS65216.1 - 1.9e-06 26.9 0.0 4.1e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETS65216.1 - 0.00046 19.6 0.0 0.0019 17.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like ABC1 PF03109.16 ETS65216.1 - 0.052 13.7 0.1 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 ABC1 family Pkinase PF00069.25 ETS65217.1 - 1.3e-73 247.6 0.0 1.7e-73 247.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65217.1 - 6.6e-32 110.8 0.0 8.3e-32 110.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS65217.1 - 5.5e-09 35.8 0.0 9.2e-09 35.0 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETS65217.1 - 2.9e-05 23.1 0.2 0.0001 21.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETS65217.1 - 0.0017 17.7 0.2 0.0031 16.9 0.2 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETS65217.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Mito_carr PF00153.27 ETS65218.1 - 3.7e-44 148.6 2.0 4.4e-15 55.4 0.2 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein DIE2_ALG10 PF04922.12 ETS65219.1 - 2.1e-91 307.2 6.7 7e-72 242.9 5.8 2.2 2 0 0 2 2 2 2 DIE2/ALG10 family Cu-oxidase_3 PF07732.15 ETS65219.1 - 8.4e-30 103.2 0.5 6.8e-27 93.8 0.1 2.7 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 ETS65219.1 - 1.1e-20 74.4 0.0 1.5e-16 60.9 0.0 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ETS65219.1 - 6.4e-14 51.9 8.1 2.5e-12 46.7 4.7 3.7 3 1 0 3 3 3 1 Multicopper oxidase DUF389 PF04087.14 ETS65219.1 - 0.15 12.1 12.6 0.54 10.3 0.6 3.6 1 1 1 3 3 3 0 Domain of unknown function (DUF389) Mrr_cat PF04471.12 ETS65219.1 - 0.19 11.8 0.1 0.5 10.4 0.1 1.7 1 0 0 1 1 1 0 Restriction endonuclease NAD_binding_5 PF07994.12 ETS65220.1 - 5.5e-145 482.8 0.0 6.6e-145 482.5 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 ETS65220.1 - 1.4e-42 144.3 0.0 2.8e-42 143.4 0.0 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase LLC1 PF14945.6 ETS65220.1 - 0.15 12.7 0.0 0.3 11.7 0.0 1.5 1 0 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein HOOK PF05622.12 ETS65221.1 - 1.3e-56 192.2 51.2 1.3e-56 192.2 51.2 3.2 2 1 2 4 4 4 1 HOOK protein CH PF00307.31 ETS65221.1 - 0.012 15.7 0.2 0.052 13.7 0.0 2.2 2 0 0 2 2 2 0 Calponin homology (CH) domain Sec20 PF03908.13 ETS65221.1 - 0.17 11.8 17.4 0.12 12.3 1.5 4.6 4 0 0 4 4 4 0 Sec20 DUF3800 PF12686.7 ETS65221.1 - 0.35 11.5 1.9 1.1e+02 3.4 3.3 3.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) NYD-SP28_assoc PF14775.6 ETS65221.1 - 2.6 8.2 11.3 0.6 10.3 2.2 4.0 3 0 0 3 3 3 0 Sperm tail C-terminal domain HALZ PF02183.18 ETS65221.1 - 4.6 7.6 34.9 1.6 9.0 0.7 7.7 6 2 1 7 7 7 0 Homeobox associated leucine zipper Pox_A_type_inc PF04508.12 ETS65221.1 - 7.3 6.6 21.7 32 4.6 0.0 6.2 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat TRAPP PF04051.16 ETS65222.1 - 6.9e-39 132.9 0.0 1.2e-38 132.1 0.0 1.4 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SIKE PF05769.11 ETS65222.1 - 0.59 10.0 17.7 0.093 12.7 8.9 2.8 3 0 0 3 3 3 0 SIKE family DUF2188 PF09954.9 ETS65222.1 - 0.85 9.8 4.7 0.37 11.0 0.8 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) INCENP_ARK-bind PF03941.15 ETS65222.1 - 1.9 8.5 4.8 41 4.2 0.0 2.8 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region Methyltransf_23 PF13489.6 ETS65223.1 - 2.2e-12 47.2 0.1 4.4e-12 46.2 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS65223.1 - 6e-11 43.0 0.0 1.6e-10 41.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS65223.1 - 8.1e-07 29.7 0.0 2.1e-06 28.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETS65223.1 - 2.1e-05 24.2 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.12 ETS65223.1 - 0.00097 19.7 0.0 0.0024 18.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS65223.1 - 0.013 15.3 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PTS_EIIA_2 PF00359.22 ETS65223.1 - 0.087 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 Arf PF00025.21 ETS65224.1 - 1.9e-64 216.3 0.0 2.2e-64 216.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETS65224.1 - 5.9e-13 49.1 0.1 8.7e-13 48.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETS65224.1 - 1.4e-12 47.4 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ETS65224.1 - 5.2e-12 45.6 0.0 6.6e-12 45.3 0.0 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ETS65224.1 - 1.5e-10 40.8 0.6 3.1e-08 33.2 0.1 2.1 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 ETS65224.1 - 2.2e-09 37.4 0.0 3e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETS65224.1 - 1.1e-06 28.1 0.0 1.4e-06 27.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETS65224.1 - 7.8e-06 25.6 0.0 0.002 17.7 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ETS65224.1 - 0.0018 17.8 0.2 0.0054 16.3 0.1 1.8 1 1 1 2 2 2 1 Ferrous iron transport protein B IES5 PF17335.2 ETS65224.1 - 0.056 13.7 0.0 0.094 13.0 0.0 1.3 1 0 0 1 1 1 0 Ino80 complex subunit 5 AAA_24 PF13479.6 ETS65224.1 - 0.13 12.0 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Mannosyl_trans2 PF04188.13 ETS65225.1 - 3.3e-46 158.5 10.8 4.1e-46 158.2 10.8 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-V) LPP PF04728.13 ETS65226.1 - 0.0045 17.3 2.5 0.013 15.9 2.5 1.7 1 0 0 1 1 1 1 Lipoprotein leucine-zipper Gly-zipper_Omp PF13488.6 ETS65226.1 - 8.4 6.5 18.6 3.5 7.7 0.9 2.6 2 1 0 2 2 2 0 Glycine zipper LSM14 PF12701.7 ETS65227.1 - 3.5e-29 100.7 0.0 5.2e-29 100.2 0.0 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 ETS65227.1 - 9.6e-07 28.9 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain FDF PF09532.10 ETS65227.1 - 2.9e-06 28.1 0.9 0.016 16.1 0.5 2.7 2 0 0 2 2 2 2 FDF domain Lon_C PF05362.13 ETS65228.1 - 1.7e-68 230.2 0.0 2.7e-68 229.6 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 ETS65228.1 - 7.4e-23 81.4 0.0 1.7e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 ETS65228.1 - 1.1e-11 45.1 0.0 1.2e-10 41.7 0.0 2.1 1 1 1 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_5 PF07728.14 ETS65228.1 - 5.5e-10 39.4 0.0 1.5e-09 38.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 ETS65228.1 - 1e-07 31.9 0.0 1.9e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 ETS65228.1 - 0.00011 22.4 0.0 0.00045 20.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ETS65228.1 - 0.00022 21.7 0.0 0.00022 21.7 0.0 2.9 3 1 0 3 3 1 1 AAA ATPase domain AAA_22 PF13401.6 ETS65228.1 - 0.00045 20.5 0.2 0.0092 16.3 0.0 2.8 2 1 0 2 2 1 1 AAA domain AAA_33 PF13671.6 ETS65228.1 - 0.00096 19.3 0.1 0.0086 16.2 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETS65228.1 - 0.0017 18.9 1.0 0.039 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETS65228.1 - 0.0092 15.4 0.1 0.027 13.9 0.0 1.7 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETS65228.1 - 0.011 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETS65228.1 - 0.018 14.8 0.0 0.079 12.7 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ETS65228.1 - 0.028 14.8 0.0 0.067 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 ETS65228.1 - 0.032 13.8 0.0 0.083 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETS65228.1 - 0.042 13.6 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETS65228.1 - 0.046 13.2 0.0 0.085 12.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_PrkA PF08298.11 ETS65228.1 - 0.054 12.4 0.0 0.41 9.5 0.0 2.1 2 0 0 2 2 2 0 PrkA AAA domain ATPase PF06745.13 ETS65228.1 - 0.063 12.6 0.0 25 4.1 0.0 3.2 3 0 0 3 3 3 0 KaiC IstB_IS21 PF01695.17 ETS65228.1 - 0.071 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Rad17 PF03215.15 ETS65228.1 - 0.087 12.7 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_24 PF13479.6 ETS65228.1 - 0.092 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ETS65228.1 - 0.1 11.8 0.0 0.19 10.9 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain KTI12 PF08433.10 ETS65228.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_11 PF13086.6 ETS65228.1 - 0.14 12.0 1.4 0.22 11.2 0.1 2.0 1 1 1 2 2 2 0 AAA domain NACHT PF05729.12 ETS65228.1 - 0.14 12.1 0.0 0.44 10.5 0.0 1.8 1 0 0 1 1 1 0 NACHT domain eIF-5_eIF-2B PF01873.17 ETS65229.1 - 8e-39 132.1 0.0 1.3e-38 131.4 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 ETS65229.1 - 6.8e-20 71.0 0.0 6.8e-20 71.0 0.0 3.0 4 0 0 4 4 4 1 eIF4-gamma/eIF5/eIF2-epsilon Sigma70_ner PF04546.13 ETS65229.1 - 0.004 17.1 0.0 6.4 6.6 0.0 2.6 2 1 0 2 2 2 1 Sigma-70, non-essential region Cwf_Cwc_15 PF04889.12 ETS65229.1 - 0.047 13.4 15.3 0.19 11.5 7.5 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DNA_RNApol_7kD PF03604.13 ETS65229.1 - 1.3 8.7 4.7 0.57 9.9 2.1 1.8 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit MAPEG PF01124.18 ETS65230.1 - 3.3e-19 69.1 3.6 6.5e-19 68.1 3.6 1.4 1 0 0 1 1 1 1 MAPEG family Ferritin_2 PF13668.6 ETS65231.1 - 4.7e-41 140.2 1.6 8.5e-41 139.3 1.6 1.4 1 0 0 1 1 1 1 Ferritin-like domain L-fibroin PF05849.11 ETS65231.1 - 0.0038 16.6 0.2 0.0079 15.5 0.2 1.5 1 0 0 1 1 1 1 Fibroin light chain (L-fibroin) Cullin PF00888.22 ETS65232.1 - 3.2e-165 551.2 0.0 4.5e-165 550.8 0.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ETS65232.1 - 1.8e-21 76.0 2.4 4.4e-21 74.7 2.4 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain PDEase_II PF02112.15 ETS65233.1 - 1.7e-36 126.0 0.0 7.3e-22 77.9 0.0 3.2 3 1 0 3 3 3 2 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 ETS65233.1 - 0.0048 16.4 0.0 0.013 15.0 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF1860 PF08949.10 ETS65233.1 - 0.049 13.4 3.8 0.72 9.6 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1860) DUF3693 PF12472.8 ETS65233.1 - 0.37 10.5 1.4 0.44 10.2 0.0 1.9 2 0 0 2 2 2 0 Phage related protein SPT16 PF08644.11 ETS65235.1 - 9.6e-56 188.2 0.0 2.4e-55 186.9 0.0 1.8 1 0 0 1 1 1 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 ETS65235.1 - 3e-50 170.2 0.2 7e-50 169.0 0.2 1.7 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 ETS65235.1 - 2.4e-29 102.5 0.0 5.1e-29 101.5 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 ETS65235.1 - 4.2e-15 55.9 0.1 1.5e-14 54.2 0.1 2.0 1 0 0 1 1 1 1 Histone chaperone Rttp106-like DNA_binding_1 PF01035.20 ETS65236.1 - 4e-23 81.4 0.0 5e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain TRIC PF05197.13 ETS65237.1 - 0.031 13.9 0.7 0.13 11.8 0.7 1.9 1 1 0 1 1 1 0 TRIC channel Abhydrolase_1 PF00561.20 ETS65238.1 - 1.9e-18 67.0 0.0 7.7e-17 61.8 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETS65238.1 - 3e-16 59.4 0.0 4.8e-16 58.8 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETS65238.1 - 1.5e-15 58.4 0.2 2.1e-15 57.9 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ETS65238.1 - 1e-05 25.2 0.1 0.042 13.4 0.2 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Peptidase_S9 PF00326.21 ETS65238.1 - 1.3e-05 24.8 0.1 0.13 11.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Thioesterase PF00975.20 ETS65238.1 - 0.00028 21.1 0.1 0.0021 18.2 0.1 2.1 1 1 0 1 1 1 1 Thioesterase domain Esterase PF00756.20 ETS65238.1 - 0.0022 17.7 0.0 0.0051 16.5 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 ETS65238.1 - 0.0047 16.8 0.1 0.053 13.4 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 ETS65238.1 - 0.04 13.4 0.1 2.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Esterase PHB depolymerase LEA_5 PF00477.17 ETS65238.1 - 0.1 13.1 0.1 0.18 12.3 0.1 1.3 1 0 0 1 1 1 0 Small hydrophilic plant seed protein AAA PF00004.29 ETS65239.1 - 2.3e-32 112.2 0.0 4e-32 111.4 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETS65239.1 - 1.3e-07 31.9 0.2 8.8e-07 29.3 0.2 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETS65239.1 - 5e-07 30.3 0.2 3.4e-06 27.5 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 ETS65239.1 - 3.3e-05 24.1 0.9 0.00017 21.8 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ETS65239.1 - 6.1e-05 23.2 0.0 0.00014 22.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ETS65239.1 - 9.1e-05 23.0 0.0 0.00018 22.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ETS65239.1 - 0.00029 20.9 0.0 0.00054 20.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ETS65239.1 - 0.00033 20.6 0.3 0.0034 17.3 0.3 2.5 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 ETS65239.1 - 0.00061 19.8 0.4 0.16 11.9 0.4 2.2 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ETS65239.1 - 0.00069 19.4 0.0 0.0029 17.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 ETS65239.1 - 0.00098 18.4 0.3 0.012 14.7 0.3 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 ETS65239.1 - 0.0015 18.3 0.0 0.0073 16.1 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein RNA_helicase PF00910.22 ETS65239.1 - 0.002 18.5 0.0 0.0055 17.1 0.0 1.7 1 0 0 1 1 1 1 RNA helicase RuvB_N PF05496.12 ETS65239.1 - 0.0021 17.8 0.1 0.0054 16.5 0.1 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 ETS65239.1 - 0.0028 17.4 0.0 0.0078 16.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETS65239.1 - 0.003 17.6 0.4 0.0095 15.9 0.4 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ETS65239.1 - 0.003 17.8 0.0 0.0071 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETS65239.1 - 0.0031 17.3 0.4 0.0083 15.9 0.1 1.9 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 ETS65239.1 - 0.0037 17.3 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 ETS65239.1 - 0.0077 15.8 6.2 0.18 11.4 0.1 3.2 3 1 1 4 4 3 1 AAA domain AAA_17 PF13207.6 ETS65239.1 - 0.012 16.0 0.1 0.044 14.2 0.0 2.0 2 1 0 2 2 1 0 AAA domain TIP49 PF06068.13 ETS65239.1 - 0.013 14.8 0.0 0.018 14.2 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain Viral_helicase1 PF01443.18 ETS65239.1 - 0.013 15.3 0.0 0.027 14.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Cytidylate_kin PF02224.18 ETS65239.1 - 0.013 15.3 0.1 0.013 15.3 0.1 2.1 2 1 0 2 2 2 0 Cytidylate kinase ABC_tran PF00005.27 ETS65239.1 - 0.013 16.0 0.0 0.029 14.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 ETS65239.1 - 0.014 15.0 0.0 0.039 13.5 0.0 1.7 2 0 0 2 2 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 ETS65239.1 - 0.017 15.4 1.1 0.2 12.0 0.0 3.1 4 1 1 5 5 3 0 AAA domain KAP_NTPase PF07693.14 ETS65239.1 - 0.019 14.2 0.1 4.7 6.3 0.1 2.3 1 1 1 2 2 2 0 KAP family P-loop domain Rad17 PF03215.15 ETS65239.1 - 0.029 14.3 0.1 0.075 13.0 0.1 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain DUF2075 PF09848.9 ETS65239.1 - 0.033 13.4 0.0 0.049 12.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Mg_chelatase PF01078.21 ETS65239.1 - 0.045 13.1 0.0 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.9 ETS65239.1 - 0.084 12.6 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ATPase PF06745.13 ETS65239.1 - 0.1 11.9 1.6 1.2 8.4 0.0 2.6 2 1 1 3 3 2 0 KaiC AAA_3 PF07726.11 ETS65239.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 ETS65239.1 - 0.16 11.4 0.0 0.45 9.9 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_6 PF12774.7 ETS65239.1 - 0.16 10.9 0.0 0.26 10.2 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_13 PF13166.6 ETS65239.1 - 0.21 10.2 0.0 0.48 9.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain MAP17 PF15807.5 ETS65240.1 - 0.00017 21.8 1.9 0.0002 21.6 1.0 1.6 1 1 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 HemX PF04375.14 ETS65240.1 - 0.014 14.7 8.6 0.026 13.8 8.6 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase ALMT PF11744.8 ETS65240.1 - 0.26 10.1 2.1 0.32 9.8 2.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 ETS65240.1 - 0.37 9.5 5.7 0.48 9.2 5.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETS65240.1 - 0.62 8.8 6.7 0.78 8.4 6.7 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETS65240.1 - 0.94 9.3 3.9 1.3 8.8 3.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MCM_bind PF09739.9 ETS65240.1 - 1.2 7.5 5.3 1.5 7.1 5.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CDC45 PF02724.14 ETS65240.1 - 1.9 6.7 7.2 2.5 6.3 7.2 1.1 1 0 0 1 1 1 0 CDC45-like protein EphA2_TM PF14575.6 ETS65240.1 - 5.2 8.0 7.9 3.7e+02 2.1 7.9 2.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Cyclin PF08613.11 ETS65241.1 - 2.9e-11 44.0 0.4 2.9e-11 44.0 0.4 2.3 2 1 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 ETS65241.1 - 1.1e-06 28.4 0.0 1.7e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain ANAPC4_WD40 PF12894.7 ETS65242.1 - 5.1e-06 26.7 0.0 0.035 14.4 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2415 PF10313.9 ETS65242.1 - 5.8e-06 26.1 0.1 2e-05 24.4 0.1 2.0 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) PD40 PF07676.12 ETS65242.1 - 5.3e-05 23.0 0.4 0.31 11.0 0.4 3.1 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETS65242.1 - 0.00043 21.0 5.7 0.089 13.7 1.9 4.9 4 1 1 5 5 5 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETS65242.1 - 0.013 14.5 0.1 0.042 12.8 0.1 1.7 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETS65242.1 - 0.027 13.8 0.1 0.074 12.4 0.1 1.6 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETS65242.1 - 0.029 13.1 0.1 1.2 7.8 0.0 2.8 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETS65242.1 - 1.3 8.8 5.9 15 5.4 0.8 3.3 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature zf-HC5HC2H_2 PF13832.6 ETS65243.1 - 2.7e-20 72.6 20.8 1.7e-19 70.0 1.1 4.0 3 0 0 3 3 3 2 PHD-zinc-finger like domain PHD PF00628.29 ETS65243.1 - 1.9e-15 56.4 53.2 5.2e-10 39.1 6.4 5.8 7 0 0 7 7 7 3 PHD-finger zf-HC5HC2H PF13771.6 ETS65243.1 - 6.3e-15 55.2 27.0 1e-14 54.5 1.9 4.5 4 0 0 4 4 4 3 PHD-like zinc-binding domain BAH PF01426.18 ETS65243.1 - 2.8e-08 33.6 0.0 5.3e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 BAH domain PHD_2 PF13831.6 ETS65243.1 - 1.4e-07 30.9 4.4 1.4e-07 30.9 4.4 4.7 7 0 0 7 7 7 2 PHD-finger GATA PF00320.27 ETS65243.1 - 3.7e-06 26.4 2.2 3.7e-06 26.4 2.2 3.5 3 0 0 3 3 3 1 GATA zinc finger ELM2 PF01448.24 ETS65243.1 - 0.00032 21.4 0.0 0.0019 18.9 0.0 2.4 2 1 0 2 2 2 1 ELM2 domain bZIP_1 PF00170.21 ETS65244.1 - 6.2e-06 26.2 6.5 1.4e-05 25.1 6.5 1.7 1 0 0 1 1 1 1 bZIP transcription factor RskA PF10099.9 ETS65244.1 - 0.00038 20.8 3.5 0.00038 20.8 3.5 3.3 1 1 1 3 3 3 2 Anti-sigma-K factor rskA EndoU_bacteria PF14436.6 ETS65244.1 - 0.015 15.6 0.3 0.042 14.2 0.3 1.8 1 1 0 1 1 1 0 Bacterial EndoU nuclease bZIP_2 PF07716.15 ETS65244.1 - 0.11 12.6 6.4 1.4 9.1 6.8 2.3 2 0 0 2 2 2 0 Basic region leucine zipper SPRY PF00622.28 ETS65245.1 - 8.5e-22 77.5 0.1 1.5e-21 76.7 0.1 1.4 1 0 0 1 1 1 1 SPRY domain Arf PF00025.21 ETS65246.1 - 2.7e-77 258.2 0.0 3.1e-77 257.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETS65246.1 - 3e-15 56.5 0.0 3.9e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETS65246.1 - 1.3e-12 47.6 0.0 1.4e-12 47.5 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ETS65246.1 - 2.2e-11 43.5 0.8 7.5e-07 28.6 0.1 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ETS65246.1 - 1.1e-10 41.2 0.0 1.4e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETS65246.1 - 3.7e-09 36.3 0.0 4.7e-09 36.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETS65246.1 - 0.00022 21.3 0.0 0.00037 20.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ETS65246.1 - 0.0016 17.8 0.1 0.0024 17.2 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase Cys_Met_Meta_PP PF01053.20 ETS65247.1 - 6.6e-148 492.3 0.0 7.5e-148 492.1 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ETS65247.1 - 6.1e-11 41.9 0.7 1.1e-10 41.0 0.7 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ETS65247.1 - 4.1e-09 36.2 0.2 6.1e-09 35.6 0.2 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ETS65247.1 - 5e-08 32.5 0.1 7.7e-08 31.9 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETS65247.1 - 0.00019 20.8 0.0 0.00036 19.9 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 ETS65247.1 - 0.00096 17.8 0.0 0.0015 17.1 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase AP_endonuc_2 PF01261.24 ETS65247.1 - 0.12 11.8 0.0 7.7 5.9 0.0 2.2 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel GDC-P PF02347.16 ETS65247.1 - 0.12 11.1 0.0 0.16 10.8 0.0 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein SepSecS PF05889.13 ETS65247.1 - 0.2 10.3 0.1 0.28 9.8 0.1 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS F_actin_cap_B PF01115.17 ETS65248.1 - 1.3e-85 286.8 0.0 1.9e-85 286.3 0.0 1.3 1 0 0 1 1 1 1 F-actin capping protein, beta subunit UDPGP PF01704.18 ETS65249.1 - 8.2e-201 667.0 0.2 9.4e-201 666.8 0.2 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase RRM_1 PF00076.22 ETS65250.1 - 9.3e-14 51.0 0.0 2.7e-07 30.3 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX14 PF14880.6 ETS65250.1 - 0.014 15.2 0.3 0.037 13.9 0.3 1.7 1 0 0 1 1 1 0 Cytochrome oxidase c assembly DUF3429 PF11911.8 ETS65251.1 - 2.5e-40 138.1 13.9 3.8e-40 137.5 13.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) DDHD PF02862.17 ETS65251.1 - 0.19 11.9 3.2 17 5.4 2.7 2.1 2 0 0 2 2 2 0 DDHD domain Paf1 PF03985.13 ETS65251.1 - 2.1 7.3 14.3 2.7 6.9 14.3 1.1 1 0 0 1 1 1 0 Paf1 DUF202 PF02656.15 ETS65252.1 - 2.2e-10 40.8 3.6 2.2e-10 40.8 3.6 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF202) Response_reg PF00072.24 ETS65253.1 - 6.9e-24 84.2 0.6 3.5e-16 59.3 0.3 2.3 1 1 1 2 2 2 2 Response regulator receiver domain AAA_5 PF07728.14 ETS65255.1 - 6.2e-61 204.4 0.0 2.6e-26 92.2 0.0 3.7 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) MTA_R1 PF17226.2 ETS65255.1 - 0.1 12.8 0.1 0.32 11.2 0.1 1.8 1 0 0 1 1 1 0 MTA R1 domain DUF1967 PF09269.11 ETS65255.1 - 0.18 11.8 0.1 0.47 10.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) MCM PF00493.23 ETS65255.1 - 0.19 10.8 0.0 0.44 9.6 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain SRI PF08236.11 ETS65255.1 - 0.4 10.9 1.1 0.85 9.8 1.1 1.5 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Mito_carr PF00153.27 ETS65258.1 - 2.3e-62 207.0 5.7 3.6e-20 71.7 0.3 3.8 3 1 0 3 3 3 3 Mitochondrial carrier protein Sep15_SelM PF08806.11 ETS65259.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Sep15/SelM redox domain Dioxygenase_C PF00775.21 ETS65260.1 - 3.4e-42 143.9 0.0 4.4e-42 143.6 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 ETS65260.1 - 9.8e-28 95.8 0.0 1.8e-27 95.0 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 ETS65260.1 - 2.3e-07 31.0 0.0 1e-06 28.9 0.0 2.0 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 ETS65260.1 - 0.024 14.6 0.1 3.8 7.6 0.0 2.7 2 0 0 2 2 2 0 CarboxypepD_reg-like domain PPR_2 PF13041.6 ETS65261.1 - 2.5e-13 50.0 0.0 6.5e-13 48.7 0.0 1.8 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 ETS65261.1 - 1.8e-07 30.9 0.0 4.1e-05 23.6 0.0 3.6 3 0 0 3 3 3 1 PPR repeat PPR_1 PF12854.7 ETS65261.1 - 1.2e-06 28.1 0.1 0.0061 16.2 0.1 2.6 2 0 0 2 2 2 2 PPR repeat PPR_3 PF13812.6 ETS65261.1 - 5e-05 23.3 0.0 0.00012 22.0 0.0 1.6 1 0 0 1 1 1 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ETS65261.1 - 0.019 14.3 0.0 0.041 13.2 0.0 1.5 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP CHCH PF06747.13 ETS65262.1 - 1e-05 25.5 6.3 1e-05 25.5 6.3 2.4 2 0 0 2 2 2 1 CHCH domain CX9C PF16860.5 ETS65262.1 - 0.00016 21.6 11.0 0.015 15.3 5.6 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Pet191_N PF10203.9 ETS65262.1 - 0.7 10.2 11.5 2.7 8.4 8.8 2.6 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 ETS65262.1 - 2.9 8.0 12.6 8.1 6.5 6.0 2.9 1 1 3 4 4 4 0 Cytochrome c oxidase biogenesis protein Cmc1 like Iso_dh PF00180.20 ETS65263.1 - 4.7e-97 325.3 0.0 5.3e-97 325.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Aldedh PF00171.22 ETS65264.1 - 5.6e-146 486.7 0.0 6.6e-146 486.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETS65264.1 - 0.00012 21.7 0.1 0.00033 20.2 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1487) Zn_clus PF00172.18 ETS65265.1 - 0.00079 19.5 9.1 0.0015 18.6 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BNIP2 PF12496.8 ETS65265.1 - 0.28 11.6 2.7 0.85 10.1 2.7 1.8 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 3-HAO PF06052.12 ETS65266.1 - 5.3e-58 194.9 0.0 6.9e-58 194.6 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 ETS65266.1 - 1.6e-05 24.5 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ETS65266.1 - 0.0054 16.3 0.0 0.0083 15.7 0.0 1.3 1 0 0 1 1 1 1 Cupin ARD PF03079.14 ETS65266.1 - 0.0056 16.9 0.0 0.0079 16.4 0.0 1.2 1 0 0 1 1 1 1 ARD/ARD' family ThiD2 PF17792.1 ETS65267.1 - 0.21 12.0 4.7 1.9 8.9 0.3 3.0 2 0 0 2 2 2 0 ThiD2 family DUF4598 PF15370.6 ETS65267.1 - 4 7.9 6.3 2.5 8.6 2.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4598) SGL PF08450.12 ETS65269.1 - 2.3e-16 60.1 0.2 5.3e-15 55.7 0.2 2.3 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Phosphoprotein PF00922.17 ETS65270.1 - 0.4 10.2 4.3 0.55 9.8 4.3 1.2 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein Nop14 PF04147.12 ETS65270.1 - 2.2 6.4 7.1 2.4 6.3 7.1 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETS65270.1 - 6.7 6.0 9.2 7.6 5.9 9.2 1.1 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 ETS65270.1 - 6.8 6.4 13.8 13 5.4 13.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Tam41_Mmp37 PF09139.11 ETS65272.1 - 8.7e-113 377.0 0.0 1e-112 376.8 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Aldedh PF00171.22 ETS65274.1 - 6.5e-160 532.6 2.8 8.4e-160 532.3 2.8 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETS65274.1 - 0.012 15.0 0.0 0.052 13.0 0.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1487) EVC2_like PF12297.8 ETS65274.1 - 0.096 11.4 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein WD40 PF00400.32 ETS65275.1 - 8.7e-07 29.6 0.1 0.18 12.8 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETS65275.1 - 0.0081 15.2 0.0 0.53 9.2 0.0 2.1 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETS65275.1 - 0.017 13.9 0.0 0.031 13.0 0.0 1.3 1 0 0 1 1 1 0 Nup133 N terminal like ANAPC4_WD40 PF12894.7 ETS65275.1 - 0.2 12.0 0.0 16 5.9 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zf-U1 PF06220.12 ETS65276.1 - 3.1e-19 68.5 4.2 4.3e-19 68.0 4.2 1.2 1 0 0 1 1 1 1 U1 zinc finger PG_binding_4 PF12229.8 ETS65276.1 - 0.21 11.9 0.0 0.29 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Amino_oxidase PF01593.24 ETS65277.1 - 5e-32 111.8 0.0 5.2e-21 75.5 0.0 2.5 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETS65277.1 - 6.7e-15 55.1 0.5 2.7e-14 53.1 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Snf7 PF03357.21 ETS65277.1 - 2e-12 47.1 8.2 2e-12 47.1 8.2 3.5 2 1 2 4 4 3 1 Snf7 DAO PF01266.24 ETS65277.1 - 1.6e-05 24.7 6.8 2.4e-05 24.1 0.8 3.1 2 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ETS65277.1 - 0.00017 21.6 0.1 0.066 13.2 0.0 2.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 ETS65277.1 - 0.00026 20.2 0.1 0.00065 18.9 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS65277.1 - 0.00089 18.6 0.2 0.0049 16.1 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETS65277.1 - 0.0069 15.5 0.1 0.019 14.0 0.0 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein HI0933_like PF03486.14 ETS65277.1 - 0.013 14.2 0.0 0.088 11.5 0.0 2.4 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 ETS65277.1 - 0.014 14.7 0.0 0.027 13.7 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 ETS65277.1 - 0.025 15.2 0.3 0.11 13.1 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETS65277.1 - 0.04 13.2 1.6 0.47 9.7 0.0 2.9 3 0 0 3 3 3 0 FAD binding domain Ist1 PF03398.14 ETS65277.1 - 0.044 13.7 2.5 0.12 12.3 2.5 1.7 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DMSP_lyase PF16867.5 ETS65277.1 - 0.086 12.5 0.6 1.8 8.2 0.0 2.8 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase YojJ PF10372.9 ETS65277.1 - 2.5 8.2 4.5 19 5.4 0.1 3.6 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Beta-lactamase PF00144.24 ETS65278.1 - 1.9e-33 116.1 0.0 3.9e-33 115.1 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase Aldo_ket_red PF00248.21 ETS65280.1 - 7.1e-49 166.6 0.0 7.1e-47 160.0 0.0 2.2 1 1 0 1 1 1 1 Aldo/keto reductase family bZIP_1 PF00170.21 ETS65281.1 - 1.7e-05 24.8 17.4 1.7e-05 24.8 17.4 2.0 2 1 0 2 2 2 1 bZIP transcription factor Tim54 PF11711.8 ETS65281.1 - 7.8 5.2 8.8 0.2 10.4 1.0 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Dcc1 PF09724.9 ETS65283.1 - 3e-77 260.2 0.0 3.5e-77 259.9 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 AbiEi_3 PF11459.8 ETS65283.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system tRNA_m1G_MT PF01746.21 ETS65284.1 - 1.7e-19 70.3 0.0 1.1e-14 54.6 0.0 3.1 2 1 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase DUF755 PF05501.11 ETS65285.1 - 3.5 7.9 13.4 0.074 13.3 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF755) zf-H2C2_2 PF13465.6 ETS65289.1 - 2.3e-07 30.9 16.2 0.0004 20.7 5.0 4.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETS65289.1 - 2.9e-07 30.6 19.4 0.00061 20.1 3.4 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETS65289.1 - 0.0029 18.3 16.3 0.053 14.4 1.4 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 ETS65289.1 - 0.097 13.3 0.2 0.36 11.5 0.2 2.0 1 0 0 1 1 1 0 FOXP coiled-coil domain eIF3_subunit PF08597.10 ETS65290.1 - 2.7e-51 174.8 31.5 3.3e-51 174.6 31.5 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit S1FA PF04689.13 ETS65290.1 - 0.11 12.6 2.0 3.2 8.0 1.5 2.7 2 0 0 2 2 2 0 DNA binding protein S1FA Response_reg PF00072.24 ETS65291.1 - 5.6e-20 71.6 0.1 1.5e-19 70.2 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 ETS65291.1 - 9.3e-14 51.9 0.0 1.7e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 ETS65291.1 - 4e-06 26.8 0.6 1.2e-05 25.3 0.6 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain F-box-like PF12937.7 ETS65292.1 - 1.2e-05 25.2 0.2 0.068 13.1 0.0 2.8 2 0 0 2 2 2 2 F-box-like TPR_2 PF07719.17 ETS65292.1 - 0.0039 17.2 0.3 0.013 15.6 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat F-box PF00646.33 ETS65292.1 - 0.0039 17.0 2.2 0.29 11.1 0.3 2.4 2 0 0 2 2 2 2 F-box domain TPR_11 PF13414.6 ETS65292.1 - 0.005 16.5 0.3 0.016 14.9 0.0 1.9 2 0 0 2 2 2 1 TPR repeat MIT PF04212.18 ETS65292.1 - 0.011 15.8 0.2 0.032 14.3 0.2 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETS65292.1 - 0.014 16.2 1.0 0.083 13.8 1.0 2.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETS65292.1 - 0.018 14.9 0.2 0.099 12.5 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Tubulin_3 PF14881.6 ETS65293.1 - 4.9e-32 111.1 0.3 2e-31 109.1 0.3 1.9 1 1 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 ETS65293.1 - 3.3e-28 98.4 0.1 7.9e-28 97.1 0.1 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain UBX PF00789.20 ETS65294.1 - 4.4e-07 30.0 0.0 1.3e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 ETS65294.1 - 0.0017 18.2 0.1 0.0068 16.3 0.0 2.1 2 0 0 2 2 2 1 UBA/TS-N domain Jas PF16135.5 ETS65294.1 - 0.085 13.0 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling zf-C2H2 PF00096.26 ETS65294.1 - 0.11 13.1 0.7 0.22 12.0 0.7 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ETS65294.1 - 0.15 12.4 1.6 0.17 12.3 0.1 1.8 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) CpXC PF14353.6 ETS65294.1 - 0.26 11.3 3.4 0.68 10.0 3.2 1.8 1 1 0 1 1 1 0 CpXC protein RskA PF10099.9 ETS65294.1 - 4.8 7.5 22.8 0.047 14.0 11.6 2.5 3 0 0 3 3 3 0 Anti-sigma-K factor rskA DUF572 PF04502.13 ETS65294.1 - 9.3 5.8 21.6 12 5.4 19.2 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF572) CoaE PF01121.20 ETS65295.1 - 1.9e-51 174.3 0.0 2.5e-51 173.9 0.0 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase MFS_1 PF07690.16 ETS65296.1 - 1.1e-32 113.4 41.0 1.1e-32 113.4 41.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Zn_clus PF00172.18 ETS65297.1 - 0.0041 17.2 1.7 0.0041 17.2 1.7 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 ETS65298.1 - 5e-73 245.7 0.0 6e-73 245.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65298.1 - 4.1e-31 108.2 0.0 5.4e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS65298.1 - 2.5e-05 23.7 0.1 0.0036 16.7 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ETS65298.1 - 0.016 15.2 0.6 0.064 13.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETS65298.1 - 0.022 13.7 0.0 1.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Haspin like kinase domain Choline_kinase PF01633.20 ETS65299.1 - 1.3e-35 122.9 0.0 1.4e-22 80.3 0.0 2.9 4 0 0 4 4 4 2 Choline/ethanolamine kinase APH PF01636.23 ETS65299.1 - 7.5e-05 22.8 0.1 0.05 13.5 0.0 2.6 2 0 0 2 2 2 2 Phosphotransferase enzyme family Hira PF07569.11 ETS65301.1 - 1.3e-50 172.2 0.0 2.8e-50 171.1 0.0 1.6 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 ETS65301.1 - 1.1e-23 83.0 23.8 2.5e-06 28.1 0.0 8.1 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS65301.1 - 6.5e-10 39.2 0.6 0.44 10.9 0.0 6.0 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 ETS65301.1 - 6.6e-09 35.4 1.7 1.9e-08 33.9 1.7 1.8 1 0 0 1 1 1 1 HIRA B motif Ge1_WD40 PF16529.5 ETS65301.1 - 0.011 14.8 1.1 8.6 5.2 0.0 3.8 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETS65301.1 - 0.022 14.7 3.3 0.76 9.8 0.3 3.4 3 1 0 3 3 3 0 WD40-like Beta Propeller Repeat Semialdhyde_dhC PF02774.18 ETS65302.1 - 7.7e-45 153.2 0.0 1.2e-44 152.5 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 ETS65302.1 - 5.5e-27 94.6 0.0 1.1e-26 93.6 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ETS65302.1 - 0.0041 17.2 0.0 0.01 16.0 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus DXP_reductoisom PF02670.16 ETS65302.1 - 0.032 14.9 0.0 0.084 13.6 0.0 1.8 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Gp_dh_C PF02800.20 ETS65302.1 - 0.086 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain CTP_transf_1 PF01148.20 ETS65303.1 - 0.0038 17.0 0.6 0.0053 16.5 0.6 1.3 1 0 0 1 1 1 1 Cytidylyltransferase family Glyco_hydro_43 PF04616.14 ETS65304.1 - 2.8e-36 125.3 0.0 3.3e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 ACOX PF01756.19 ETS65305.1 - 6.7e-45 152.9 0.0 1.2e-44 152.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ETS65305.1 - 1.4e-19 70.1 0.0 2.5e-19 69.2 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 ETS65305.1 - 3.8e-10 40.4 0.0 1.6e-09 38.4 0.0 2.1 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 ETS65305.1 - 7.1e-09 36.0 1.4 3.9e-07 30.4 1.9 3.1 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain COPIIcoated_ERV PF07970.12 ETS65306.1 - 3.8e-84 282.0 0.3 5.6e-84 281.4 0.3 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ETS65306.1 - 1.6e-28 98.8 0.0 4.8e-28 97.3 0.0 1.8 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Uds1 PF15456.6 ETS65307.1 - 1.4e-34 119.1 4.5 1.4e-34 119.1 4.5 10.0 6 2 2 8 8 8 1 Up-regulated During Septation ABC_tran_CTD PF16326.5 ETS65307.1 - 0.01 16.1 1.8 0.01 16.1 1.8 12.6 7 2 7 15 15 15 0 ABC transporter C-terminal domain PKcGMP_CC PF16808.5 ETS65307.1 - 0.024 14.5 0.1 0.024 14.5 0.1 7.4 8 0 0 8 8 8 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Complex1_49kDa PF00346.19 ETS65308.1 - 1.6e-121 404.6 0.0 2.1e-121 404.2 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 ETS65308.1 - 0.0034 16.4 0.0 0.0056 15.6 0.0 1.4 1 0 0 1 1 1 1 Nickel-dependent hydrogenase Pkinase PF00069.25 ETS65309.1 - 3.6e-72 242.9 0.0 4.5e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65309.1 - 3.5e-35 121.5 0.0 5.4e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETS65309.1 - 2.3e-05 23.8 0.1 0.0001 21.7 0.0 1.8 1 1 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ETS65309.1 - 0.00049 19.1 0.1 0.075 12.0 0.1 2.1 2 0 0 2 2 2 2 Haspin like kinase domain Kdo PF06293.14 ETS65309.1 - 0.014 14.8 0.7 0.038 13.3 0.7 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Asp PF00026.23 ETS65310.1 - 1.2e-106 356.8 0.1 1.4e-106 356.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETS65310.1 - 3.5e-13 50.2 1.5 2.9e-11 43.9 1.5 2.5 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETS65310.1 - 0.00065 20.3 0.1 0.28 11.8 0.0 3.1 2 1 0 2 2 2 1 Aspartyl protease TAXi_C PF14541.6 ETS65310.1 - 0.006 16.4 0.0 0.038 13.8 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ETS65310.1 - 0.0088 16.6 0.0 2.9 8.5 0.0 2.7 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease G6PD_C PF02781.16 ETS65312.1 - 7.2e-110 366.7 0.0 1.2e-109 366.1 0.0 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ETS65312.1 - 6.6e-60 202.8 0.1 1.2e-59 201.9 0.1 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain CpxA_peri PF16527.5 ETS65312.1 - 0.11 12.8 0.1 0.22 11.9 0.1 1.4 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain Rad4 PF03835.15 ETS65313.1 - 2e-27 95.7 0.2 5.7e-27 94.2 0.2 1.8 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 ETS65313.1 - 1.2e-26 92.9 0.1 2.6e-26 91.8 0.1 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_2 PF10404.9 ETS65313.1 - 1.7e-14 54.5 0.5 1.7e-14 54.5 0.5 4.7 5 1 0 5 5 5 1 Rad4 beta-hairpin domain 2 BHD_1 PF10403.9 ETS65313.1 - 7.7e-13 48.1 0.0 1.7e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 ETS65313.1 - 1.2e-07 32.2 1.3 1.7e-05 25.2 0.0 3.3 3 0 0 3 3 3 1 Transglutaminase-like superfamily RS4NT PF08071.12 ETS65313.1 - 0.038 14.1 0.1 0.084 13.0 0.1 1.6 1 0 0 1 1 1 0 RS4NT (NUC023) domain PI3_PI4_kinase PF00454.27 ETS65314.1 - 2.9e-32 112.4 0.0 1.1e-31 110.5 0.0 1.8 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETS65314.1 - 4.8e-05 22.8 0.5 9.3e-05 21.9 0.5 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Pik1 PF11522.8 ETS65314.1 - 0.0025 17.7 0.1 0.007 16.3 0.1 1.8 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 ETS65314.1 - 0.11 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) OCD_Mu_crystall PF02423.15 ETS65315.1 - 2.7e-22 79.1 2.3 5.3e-22 78.2 2.3 1.5 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family ANAPC4_WD40 PF12894.7 ETS65317.1 - 4.4e-06 26.9 0.0 0.19 12.1 0.0 4.0 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETS65317.1 - 0.00014 22.6 0.4 0.31 12.0 0.0 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat Hira PF07569.11 ETS65317.1 - 0.15 11.8 0.0 2.1 8.0 0.0 2.2 2 0 0 2 2 2 0 TUP1-like enhancer of split Autophagy_act_C PF03987.15 ETS65318.1 - 2.3e-11 44.1 0.1 4.8e-11 43.1 0.1 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Fer4_24 PF18109.1 ETS65318.1 - 0.15 12.4 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 Ferredoxin I 4Fe-4S cluster domain WD40 PF00400.32 ETS65320.1 - 5.2e-24 84.1 14.8 4.3e-05 24.2 0.6 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETS65320.1 - 0.0026 18.0 0.2 7.8 6.9 0.0 4.4 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETS65320.1 - 0.023 13.7 0.1 2.6 6.9 0.0 3.1 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CLTH PF10607.9 ETS65321.1 - 1.9e-20 73.3 0.0 3.5e-20 72.4 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ETS65321.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.5 1 0 0 1 1 1 0 LisH NIF PF03031.18 ETS65322.1 - 3.2e-13 49.7 0.0 0.00055 19.7 0.0 3.3 3 0 0 3 3 3 3 NLI interacting factor-like phosphatase DUF2613 PF11021.8 ETS65323.1 - 0.017 15.2 1.6 0.091 12.9 0.3 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2613) PP_kinase_C_1 PF17941.1 ETS65323.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 1 DUF4834 PF16118.5 ETS65323.1 - 0.83 10.7 3.3 21 6.2 0.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) zf-C3HC4 PF00097.25 ETS65324.1 - 9.5e-06 25.4 4.4 9.5e-06 25.4 4.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETS65324.1 - 4.2e-05 23.5 6.6 4.2e-05 23.5 6.6 1.8 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETS65324.1 - 0.00024 20.9 6.7 0.00024 20.9 6.7 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETS65324.1 - 0.00026 20.9 6.6 0.00026 20.9 6.6 2.1 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETS65324.1 - 0.0013 19.1 11.3 0.0013 19.1 11.3 2.8 3 0 0 3 3 3 1 Ring finger domain zf-rbx1 PF12678.7 ETS65324.1 - 0.1 12.9 11.2 0.052 13.8 5.3 2.5 2 0 0 2 2 2 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 ETS65324.1 - 3.2 7.5 11.6 0.23 11.1 5.0 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ETS65324.1 - 6.9 6.6 15.8 0.21 11.5 7.4 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 Arginase PF00491.21 ETS65325.1 - 4.8e-79 265.8 0.0 5.8e-79 265.5 0.0 1.0 1 0 0 1 1 1 1 Arginase family Methyltransf_31 PF13847.6 ETS65326.1 - 1.6e-06 28.0 0.0 2.1e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETS65326.1 - 7.1e-06 26.6 0.0 1.7e-05 25.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS65326.1 - 3.2e-05 24.5 0.0 7.1e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETS65326.1 - 0.00019 22.1 0.0 0.00042 21.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS65326.1 - 0.00019 21.3 0.0 0.00094 19.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 ETS65326.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Ribosomal_S26e PF01283.19 ETS65328.1 - 4.2e-48 162.2 5.0 7.1e-48 161.5 5.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S26e WW PF00397.26 ETS65329.1 - 7.9e-10 38.7 0.3 1.6e-09 37.6 0.3 1.6 1 0 0 1 1 1 1 WW domain Alg14 PF08660.11 ETS65330.1 - 8.4e-54 182.1 0.0 1.1e-53 181.8 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glutaredoxin PF00462.24 ETS65331.1 - 5.6e-14 52.1 0.0 8.3e-14 51.6 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 ETS65331.1 - 9.9e-05 22.7 0.0 0.00011 22.5 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_2 PF13098.6 ETS65331.1 - 0.0024 18.3 0.1 0.0032 17.9 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 ETS65331.1 - 0.0066 16.5 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin PF00085.20 ETS65331.1 - 0.02 14.9 0.0 0.021 14.8 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin DSBA PF01323.20 ETS65331.1 - 0.04 13.7 0.1 0.083 12.6 0.1 1.6 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF953 PF06110.11 ETS65331.1 - 0.069 12.8 0.1 0.12 12.0 0.1 1.4 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) TraF PF13728.6 ETS65331.1 - 0.16 11.8 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein EpuA PF11772.8 ETS65332.1 - 0.054 13.2 0.1 0.16 11.6 0.1 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta Pkinase PF00069.25 ETS65333.1 - 4e-68 229.6 0.0 5e-68 229.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65333.1 - 3e-26 92.3 0.0 4.2e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Slu7 PF11708.8 ETS65334.1 - 3.6e-101 338.4 18.6 3.6e-101 338.4 18.6 2.2 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor BTB_2 PF02214.22 ETS65337.1 - 8.3e-06 26.1 0.0 0.2 12.0 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain Pkinase PF00069.25 ETS65338.1 - 8e-63 212.3 5.5 1.3e-43 149.3 0.0 2.9 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65338.1 - 1.5e-24 86.7 7.5 4.2e-20 72.1 0.0 2.8 3 0 0 3 3 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETS65338.1 - 5.9e-07 28.8 0.0 5.9e-07 28.8 0.0 1.8 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ETS65338.1 - 0.014 14.8 0.0 0.014 14.8 0.0 2.3 3 0 0 3 3 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETS65338.1 - 0.055 12.2 0.0 0.055 12.2 0.0 2.3 2 1 0 2 2 1 0 Fungal protein kinase APH PF01636.23 ETS65338.1 - 0.06 13.3 0.0 0.06 13.3 0.0 4.0 1 1 2 3 3 2 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ETS65338.1 - 0.14 11.1 0.0 0.26 10.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_C PF00433.24 ETS65338.1 - 0.16 12.7 0.2 0.46 11.2 0.2 1.9 1 0 0 1 1 1 0 Protein kinase C terminal domain Seadorna_VP7 PF07387.11 ETS65338.1 - 0.18 10.8 0.1 0.32 10.0 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 eIF-3_zeta PF05091.12 ETS65338.1 - 0.29 10.1 14.9 0.56 9.1 14.9 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) AXIN1_TNKS_BD PF16646.5 ETS65338.1 - 1.3 10.0 4.7 5 8.1 4.7 2.0 1 0 0 1 1 1 0 Axin-1 tankyrase binding domain SPX PF03105.19 ETS65338.1 - 4.9 7.0 20.8 7.7 6.3 20.8 1.2 1 0 0 1 1 1 0 SPX domain GMC_oxred_N PF00732.19 ETS65339.1 - 1.1e-70 238.4 0.2 1.9e-70 237.6 0.1 1.4 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ETS65339.1 - 1.7e-31 109.7 0.0 3.9e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 ETS65339.1 - 1.1e-05 24.7 0.4 3.8e-05 22.9 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 ETS65339.1 - 3e-05 24.2 0.1 0.00011 22.4 0.1 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETS65339.1 - 0.00032 19.9 2.5 0.00059 19.0 0.7 2.0 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 ETS65339.1 - 0.0009 18.9 0.1 0.0009 18.9 0.1 2.4 3 0 0 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETS65339.1 - 0.0013 18.1 0.4 0.0027 17.0 0.4 1.5 1 0 0 1 1 1 1 Thi4 family Collagen PF01391.18 ETS65339.1 - 0.0013 18.4 12.4 0.0028 17.4 12.4 1.5 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) Pyr_redox_2 PF07992.14 ETS65339.1 - 0.0052 16.1 0.7 0.0097 15.2 0.7 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETS65339.1 - 0.047 13.7 0.1 0.096 12.7 0.1 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding ChAPs PF09295.10 ETS65340.1 - 2.9e-157 523.7 0.0 4.7e-157 523.0 0.0 1.3 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 ETS65340.1 - 4e-07 30.4 1.9 0.0019 18.6 0.2 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETS65340.1 - 0.00078 19.9 2.5 7.2 7.5 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETS65340.1 - 0.0033 17.6 6.9 0.011 15.9 1.3 3.8 4 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETS65340.1 - 0.0085 16.1 5.9 2.7 8.3 0.1 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat NARP1 PF12569.8 ETS65340.1 - 0.088 11.7 0.5 0.61 8.9 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TPR_14 PF13428.6 ETS65340.1 - 0.45 11.5 14.1 4.8 8.3 0.0 5.9 4 2 3 7 7 7 0 Tetratricopeptide repeat Ribosom_S12_S23 PF00164.25 ETS65341.1 - 3.1e-36 123.4 0.8 4.1e-36 123.1 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 PH_4 PF15404.6 ETS65342.1 - 1.8e-45 155.0 0.9 1.5e-44 152.0 0.0 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain DUF572 PF04502.13 ETS65342.1 - 5.3 6.6 16.2 19 4.8 16.2 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF572) IPK PF03770.16 ETS65343.1 - 2.4e-38 132.0 0.0 5.7e-37 127.5 0.0 2.2 1 1 0 1 1 1 1 Inositol polyphosphate kinase TPR_16 PF13432.6 ETS65344.1 - 0.00054 20.6 6.1 0.01 16.5 1.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETS65344.1 - 0.01 15.9 1.6 7 7.0 0.4 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Histone_HNS PF00816.21 ETS65344.1 - 0.029 15.2 4.2 6.4 7.7 1.0 3.0 3 0 0 3 3 3 0 H-NS histone family TPR_14 PF13428.6 ETS65344.1 - 0.032 15.0 3.9 0.52 11.3 0.9 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ABATE PF07336.11 ETS65344.1 - 0.047 14.3 3.1 0.11 13.2 3.1 1.6 1 1 0 1 1 1 0 Putative stress-induced transcription regulator TPR_1 PF00515.28 ETS65344.1 - 0.064 13.1 0.1 6.8 6.7 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat bVLRF1 PF18826.1 ETS65345.1 - 1e-47 161.7 0.3 2.4e-47 160.5 0.0 1.8 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor SRP14 PF02290.15 ETS65346.1 - 2.3e-20 72.7 0.0 2.3e-20 72.7 0.0 2.2 2 1 0 2 2 2 1 Signal recognition particle 14kD protein DUF726 PF05277.12 ETS65347.1 - 7.4e-116 386.8 1.3 1e-115 386.4 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Abhydrolase_1 PF00561.20 ETS65347.1 - 0.029 14.0 0.5 0.097 12.3 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Transketolase_N PF00456.21 ETS65349.1 - 8.7e-153 508.1 0.1 1.2e-152 507.7 0.1 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ETS65349.1 - 9.2e-42 142.7 0.0 1.8e-41 141.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ETS65349.1 - 1.1e-13 51.1 0.0 2.5e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ETS65349.1 - 0.077 12.2 0.1 0.35 10.0 0.1 1.9 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase LigB PF02900.18 ETS65351.1 - 3.6e-15 55.8 0.1 7.8e-14 51.4 0.1 2.1 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Raf1_HTH PF18579.1 ETS65351.1 - 0.13 12.0 0.2 0.41 10.4 0.2 1.8 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain MFS_1 PF07690.16 ETS65352.1 - 2.1e-43 148.6 25.2 2.1e-43 148.6 25.2 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS65352.1 - 1.9e-16 60.0 0.4 1.9e-16 60.0 0.4 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter FAD_binding_2 PF00890.24 ETS65353.1 - 1.8e-88 297.4 0.1 1.8e-88 297.4 0.1 1.4 2 0 0 2 2 2 1 FAD binding domain Cyt-b5 PF00173.28 ETS65353.1 - 1.3e-20 73.3 0.3 3.8e-20 71.8 0.1 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 ETS65353.1 - 3.3e-15 56.5 0.2 7.4e-15 55.4 0.2 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETS65353.1 - 1.2e-10 41.4 0.2 1e-09 38.5 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ETS65353.1 - 1.1e-09 38.2 0.6 2.8e-09 36.8 0.6 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETS65353.1 - 2.4e-09 36.8 0.1 3.7e-07 29.7 0.1 2.6 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETS65353.1 - 8.7e-07 28.0 2.6 0.00016 20.5 0.1 3.1 3 0 0 3 3 3 1 HI0933-like protein GIDA PF01134.22 ETS65353.1 - 9e-07 28.3 1.0 0.0056 15.8 0.5 2.9 3 0 0 3 3 3 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ETS65353.1 - 1.5e-06 27.7 0.1 0.0075 15.6 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETS65353.1 - 9.9e-06 25.0 2.0 3.1e-05 23.4 2.0 1.8 1 1 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETS65353.1 - 1.6e-05 24.3 0.2 0.0042 16.4 0.1 2.5 2 0 0 2 2 2 2 Thi4 family Pyr_redox PF00070.27 ETS65353.1 - 0.00011 22.6 0.7 0.0048 17.4 0.1 2.9 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ETS65353.1 - 0.00019 20.8 0.3 0.00044 19.6 0.3 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 ETS65353.1 - 0.00027 20.4 0.2 0.0016 17.8 0.1 2.2 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 ETS65353.1 - 0.03 14.3 0.1 0.48 10.4 0.0 2.6 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_7 PF13241.6 ETS65353.1 - 0.031 14.7 0.0 0.077 13.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Lycopene_cycl PF05834.12 ETS65353.1 - 0.073 12.1 0.2 0.17 10.9 0.1 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein GDI PF00996.18 ETS65353.1 - 0.19 10.2 0.0 0.31 9.5 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Nfu_N PF08712.11 ETS65354.1 - 1.8e-31 108.0 0.0 4.2e-31 106.9 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 ETS65354.1 - 8e-27 93.2 0.1 1.3e-26 92.5 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain ECH_1 PF00378.20 ETS65355.1 - 3.6e-86 288.5 1.2 4.6e-86 288.2 1.2 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETS65355.1 - 4.3e-35 121.8 1.8 1e-32 114.0 0.2 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 ETS65355.1 - 0.00025 21.0 0.1 0.15 12.0 0.0 2.7 2 1 1 3 3 3 2 Peptidase family S49 PI3K_1B_p101 PF10486.9 ETS65356.1 - 4 5.1 6.6 4.4 4.9 6.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GCP_C_terminal PF04130.13 ETS65357.1 - 1.8e-43 149.2 0.9 3.1e-43 148.4 0.9 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ETS65357.1 - 4.3e-13 49.6 0.0 1.4e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal DUF1192 PF06698.11 ETS65357.1 - 0.3 11.2 8.2 0.18 11.9 2.4 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) DNA_pol_D_N PF18018.1 ETS65358.1 - 1.8e-39 134.8 0.0 2.6e-39 134.3 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 ETS65358.1 - 2.3e-37 128.4 0.0 4.6e-37 127.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF3760 PF12586.8 ETS65359.1 - 0.16 12.2 0.4 0.34 11.1 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3760) DUF572 PF04502.13 ETS65360.1 - 1.3e-76 258.4 4.3 2.2e-76 257.7 4.3 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF572) Sporozoite_P67 PF05642.11 ETS65360.1 - 0.041 12.0 0.4 0.054 11.6 0.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-ACC PF17848.1 ETS65360.1 - 1.1 9.4 3.9 23 5.2 0.5 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain MARVEL PF01284.23 ETS65361.1 - 0.0045 17.0 11.3 0.0082 16.2 9.7 2.1 1 1 1 2 2 2 1 Membrane-associating domain DUF2583 PF10762.9 ETS65361.1 - 1.6 9.2 3.9 0.34 11.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) CRAL_TRIO PF00650.20 ETS65363.1 - 2.8e-41 140.9 0.0 4.6e-41 140.2 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Hydrolase_6 PF13344.6 ETS65363.1 - 1e-28 99.4 0.0 2.1e-28 98.4 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETS65363.1 - 1.9e-18 66.3 0.1 9.3e-18 64.1 0.1 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 ETS65363.1 - 7.6e-12 46.0 0.0 4.8e-11 43.3 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CRAL_TRIO_2 PF13716.6 ETS65363.1 - 2.2e-10 40.8 0.0 4e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain HAD_2 PF13419.6 ETS65363.1 - 1e-06 29.0 0.1 0.00079 19.6 0.0 2.5 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase CRAL_TRIO_N PF03765.15 ETS65363.1 - 3.7e-05 23.8 0.2 9.8e-05 22.5 0.2 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain PGP_phosphatase PF09419.10 ETS65363.1 - 0.068 12.8 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase DFF40 PF09230.10 ETS65364.1 - 0.13 11.9 0.0 0.17 11.4 0.0 1.1 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa CMD PF02627.20 ETS65365.1 - 4.9e-09 36.1 0.5 1.6e-08 34.4 0.1 2.1 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family Mito_carr PF00153.27 ETS65366.1 - 2.2e-52 175.0 4.8 9.1e-20 70.4 0.0 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein PGM_PMM_I PF02878.16 ETS65367.1 - 6.2e-20 71.3 0.1 3.8e-10 39.6 0.0 2.9 1 1 2 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 ETS65367.1 - 4.8e-09 36.3 0.1 1.3e-08 34.9 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_III PF02880.16 ETS65367.1 - 0.012 15.8 0.1 0.042 14.0 0.1 1.9 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ETS65367.1 - 0.036 14.7 0.7 1 10.0 0.2 3.3 3 1 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ORMDL PF04061.14 ETS65368.1 - 9.4e-56 187.4 1.9 1.1e-55 187.1 1.9 1.1 1 0 0 1 1 1 1 ORMDL family RIBIOP_C PF04950.12 ETS65369.1 - 1.1e-111 373.0 0.0 2.6e-111 371.7 0.0 1.6 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ETS65369.1 - 1.5e-20 73.1 0.0 3.7e-20 71.8 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain eIF_4EBP PF05456.11 ETS65370.1 - 4.5e-11 42.7 0.4 5e-11 42.5 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Mito_carr PF00153.27 ETS65371.1 - 7.2e-63 208.6 0.2 6.5e-25 86.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PAE PF03283.13 ETS65371.1 - 0.16 11.0 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Pectinacetylesterase Rad52_Rad22 PF04098.15 ETS65372.1 - 2.1e-57 193.4 0.0 1.4e-56 190.7 0.0 2.0 2 0 0 2 2 2 1 Rad52/22 family double-strand break repair protein Colicin_D PF11429.8 ETS65372.1 - 0.027 14.9 0.0 0.074 13.5 0.0 1.7 1 0 0 1 1 1 0 Colicin D TFIIA PF03153.13 ETS65372.1 - 5.5 6.9 11.8 9.1 6.2 11.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1687 PF07955.11 ETS65373.1 - 1.9e-13 51.0 0.0 4e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) F-box PF00646.33 ETS65374.1 - 2.8e-08 33.4 0.5 7.2e-08 32.1 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETS65374.1 - 0.00013 21.8 5.5 0.00035 20.4 5.5 1.8 1 0 0 1 1 1 1 F-box-like WD40 PF00400.32 ETS65374.1 - 0.089 13.7 0.0 1.3 10.1 0.0 2.8 3 0 0 3 3 3 0 WD domain, G-beta repeat PQQ_3 PF13570.6 ETS65374.1 - 6.3 7.4 7.2 2.9 8.5 0.0 4.1 5 0 0 5 5 5 0 PQQ-like domain DDOST_48kD PF03345.14 ETS65375.1 - 3.3e-116 388.6 0.0 4.3e-114 381.6 0.0 2.1 1 1 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Gly_radical PF01228.21 ETS65375.1 - 0.023 15.2 0.0 0.066 13.8 0.0 1.8 1 0 0 1 1 1 0 Glycine radical Nkap_C PF06047.11 ETS65376.1 - 6.2e-48 161.1 2.4 1.6e-47 159.8 2.4 1.7 1 0 0 1 1 1 1 NF-kappa-B-activating protein C-terminal domain Diphthami_syn_2 PF01902.17 ETS65377.1 - 1.3e-37 129.4 0.0 6.1e-26 91.3 0.0 2.5 2 0 0 2 2 2 2 Diphthamide synthase Ribonuc_L-PSP PF01042.21 ETS65377.1 - 4.7e-12 46.0 0.0 2.1e-06 27.7 0.0 2.9 3 0 0 3 3 3 2 Endoribonuclease L-PSP tRNA_Me_trans PF03054.16 ETS65377.1 - 0.068 11.9 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Spt5_N PF11942.8 ETS65377.1 - 0.55 11.3 4.5 0.69 10.9 0.4 2.7 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal SUV3_C PF12513.8 ETS65378.1 - 1.2e-15 57.1 0.2 3.7e-15 55.6 0.2 1.9 2 0 0 2 2 2 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 ETS65378.1 - 5.7e-12 46.0 0.0 1.2e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 ETS65378.1 - 0.00025 20.9 0.1 0.00056 19.7 0.1 1.6 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 LrgB PF04172.16 ETS65379.1 - 2.9e-33 115.2 11.6 2.9e-33 115.2 11.6 2.8 4 0 0 4 4 4 1 LrgB-like family LrgA PF03788.14 ETS65379.1 - 8.9e-05 22.4 3.4 8.9e-05 22.4 3.4 3.1 4 1 0 4 4 4 1 LrgA family Zn_clus PF00172.18 ETS65380.1 - 0.011 15.9 10.0 0.02 15.0 10.0 1.5 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ETS65380.1 - 0.056 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 PAS fold PAS_8 PF13188.7 ETS65380.1 - 0.11 12.5 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 PAS domain LCM PF04072.14 ETS65381.1 - 1.3e-16 61.1 0.0 2.2e-16 60.3 0.0 1.4 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Scs3p PF10261.9 ETS65382.1 - 8.6e-64 215.4 1.5 1.8e-63 214.3 1.5 1.5 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Ribosomal_S17 PF00366.20 ETS65384.1 - 3.2e-22 78.4 0.1 4.6e-22 77.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S17 B-block_TFIIIC PF04182.12 ETS65385.1 - 2.5e-05 24.4 0.0 6.6e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_micro PF17007.5 ETS65385.1 - 0.0092 14.9 0.0 0.014 14.2 0.0 1.1 1 0 0 1 1 1 1 HTH-like MarR PF01047.22 ETS65385.1 - 0.028 14.3 0.0 3.9 7.5 0.0 2.7 2 0 0 2 2 2 0 MarR family MarR_2 PF12802.7 ETS65385.1 - 0.07 13.0 0.7 2.4 8.1 0.0 3.3 3 0 0 3 3 3 0 MarR family F-box-like PF12937.7 ETS65386.1 - 1.6e-09 37.5 0.5 3.9e-09 36.3 0.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETS65386.1 - 3.6e-06 26.7 0.1 1e-05 25.3 0.1 1.7 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 ETS65386.1 - 0.0012 19.6 0.2 3.1 8.8 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat SUZ PF12752.7 ETS65386.1 - 2.6 8.9 5.8 19 6.1 5.8 2.6 1 0 0 1 1 1 0 SUZ domain Borealin PF10512.9 ETS65386.1 - 6.3 6.8 8.9 0.18 11.8 0.4 2.5 2 0 0 2 2 2 0 Cell division cycle-associated protein 8 Ribosomal_L28e PF01778.17 ETS65387.1 - 7.3e-30 104.1 1.8 9.2e-30 103.8 1.8 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family Hydrophobin PF01185.18 ETS65388.1 - 1.9e-14 54.0 10.9 2.8e-14 53.5 10.9 1.2 1 0 0 1 1 1 1 Fungal hydrophobin ApoO PF09769.9 ETS65389.1 - 1.7e-28 99.2 7.9 4.4e-28 97.8 0.2 3.0 1 1 2 3 3 3 1 Apolipoprotein O Syntaxin_2 PF14523.6 ETS65389.1 - 0.0055 17.1 0.4 0.1 13.0 0.4 2.1 2 0 0 2 2 2 1 Syntaxin-like protein ATP-synt_B PF00430.18 ETS65389.1 - 0.099 12.7 7.2 0.031 14.4 4.1 1.7 2 0 0 2 2 2 0 ATP synthase B/B' CF(0) DUF948 PF06103.11 ETS65389.1 - 0.13 12.5 1.2 1.5 9.1 0.4 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) YabA PF06156.13 ETS65390.1 - 0.11 13.2 4.4 0.18 12.5 4.4 1.3 1 0 0 1 1 1 0 Initiation control protein YabA APG6_N PF17675.1 ETS65390.1 - 0.14 12.7 9.5 0.21 12.1 9.5 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4470 PF14737.6 ETS65390.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) SlyX PF04102.12 ETS65390.1 - 0.27 11.9 9.7 0.61 10.7 9.7 1.6 1 0 0 1 1 1 0 SlyX CENP-H PF05837.12 ETS65390.1 - 2.5 8.5 9.7 4.5 7.7 9.7 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) HALZ PF02183.18 ETS65390.1 - 4.4 7.6 6.1 1.1 9.6 0.4 2.4 2 0 0 2 2 2 0 Homeobox associated leucine zipper PAP_assoc PF03828.19 ETS65391.1 - 2.9e-13 49.8 0.1 6.6e-13 48.7 0.1 1.6 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETS65391.1 - 1.2e-05 25.5 0.0 3e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETS65391.1 - 0.019 15.0 0.0 0.041 14.0 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Pkinase PF00069.25 ETS65392.1 - 6.2e-51 173.3 0.0 8.5e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65392.1 - 1.3e-35 123.0 0.0 2e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETS65392.1 - 1.8e-07 30.3 0.0 5.4e-07 28.7 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase PBD PF00786.28 ETS65392.1 - 2.7e-06 27.6 0.0 7.7e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 ETS65392.1 - 0.011 15.0 0.0 0.044 13.1 0.0 1.8 2 0 0 2 2 2 0 Kinase-like UBA_4 PF14555.6 ETS65395.1 - 3.2e-10 39.6 0.0 8.1e-10 38.4 0.0 1.8 1 0 0 1 1 1 1 UBA-like domain UIM PF02809.20 ETS65395.1 - 2.8e-05 23.7 11.8 0.02 14.8 3.3 2.7 2 0 0 2 2 2 2 Ubiquitin interaction motif TAP_C PF03943.13 ETS65395.1 - 0.00072 19.1 0.0 0.0014 18.2 0.0 1.5 1 0 0 1 1 1 1 TAP C-terminal domain UCH PF00443.29 ETS65395.1 - 0.0095 15.5 0.0 0.11 12.0 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4400 PF14348.6 ETS65395.1 - 0.13 11.8 0.1 0.34 10.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) S4 PF01479.25 ETS65396.1 - 3.5e-12 45.8 0.0 5.9e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 S4 domain Rtf2 PF04641.12 ETS65396.1 - 1.5 8.1 6.4 2.9 7.2 6.4 1.5 1 0 0 1 1 1 0 Rtf2 RING-finger PPP4R2 PF09184.11 ETS65396.1 - 2.4 7.6 5.1 3.7 7.0 5.1 1.2 1 0 0 1 1 1 0 PPP4R2 S-AdoMet_synt_C PF02773.16 ETS65397.1 - 3.4e-66 221.4 0.4 9.1e-66 220.1 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ETS65397.1 - 7.7e-47 158.5 0.0 1.6e-46 157.5 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ETS65397.1 - 3.8e-45 152.6 0.3 3.8e-45 152.6 0.3 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 ETS65397.1 - 0.027 13.3 0.1 0.14 10.9 0.0 2.0 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) MFS_1 PF07690.16 ETS65398.1 - 9.7e-37 126.7 55.5 7.3e-25 87.6 25.2 2.4 3 0 0 3 3 3 2 Major Facilitator Superfamily CN_hydrolase PF00795.22 ETS65399.1 - 1.1e-44 152.7 0.0 2.9e-44 151.4 0.0 1.6 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase MFS_1 PF07690.16 ETS65400.1 - 3.5e-14 52.5 36.3 3.5e-14 52.5 36.3 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily FUSC PF04632.12 ETS65400.1 - 0.71 8.3 6.7 1.2 7.6 6.7 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family HNH_3 PF13392.6 ETS65401.1 - 7.3e-07 28.8 1.6 0.0012 18.6 0.2 2.5 2 0 0 2 2 2 2 HNH endonuclease AP2 PF00847.20 ETS65401.1 - 0.31 11.3 2.7 1.7 9.0 0.0 3.1 3 0 0 3 3 3 0 AP2 domain AA_permease PF00324.21 ETS65402.1 - 4.3e-118 394.9 47.7 5.1e-118 394.7 47.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETS65402.1 - 1e-32 113.5 50.5 1.4e-32 113.1 50.5 1.2 1 0 0 1 1 1 1 Amino acid permease ALS_ss_C PF10369.9 ETS65403.1 - 9e-20 70.7 0.0 1.2e-17 63.9 0.0 2.3 2 0 0 2 2 2 2 Small subunit of acetolactate synthase ACT PF01842.25 ETS65403.1 - 1.3e-12 47.3 0.0 2.3e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 ETS65403.1 - 1.2e-06 28.2 0.0 2.9e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 ACT domain DUF2187 PF09953.9 ETS65403.1 - 0.017 15.1 0.1 0.032 14.2 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2187) Pkinase PF00069.25 ETS65405.1 - 1.8e-55 188.1 0.0 1.4e-54 185.3 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65405.1 - 4.2e-27 95.1 0.0 7.9e-26 90.9 0.0 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase PH_3 PF14593.6 ETS65405.1 - 2e-06 27.9 0.0 2.6e-05 24.3 0.0 2.4 2 0 0 2 2 2 1 PH domain Kdo PF06293.14 ETS65405.1 - 9.6e-06 25.1 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETS65405.1 - 0.0012 18.2 0.0 0.003 16.9 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETS65405.1 - 0.0044 17.0 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETS65405.1 - 0.038 12.9 0.0 0.038 12.9 0.0 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Sugar_tr PF00083.24 ETS65406.1 - 2.1e-124 415.8 20.8 2.5e-124 415.6 20.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETS65406.1 - 2.5e-21 76.0 37.9 2.3e-15 56.4 14.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Med1 PF10744.9 ETS65407.1 - 3.2e-09 36.3 0.3 9.5e-05 21.6 0.0 2.2 2 0 0 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 Methyltransf_11 PF08241.12 ETS65407.1 - 0.00015 22.4 0.0 0.00071 20.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS65407.1 - 0.00032 21.3 2.1 0.0017 19.0 0.1 3.1 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS65407.1 - 0.0047 16.8 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETS65407.1 - 0.06 13.1 0.0 0.26 11.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain UreF PF01730.16 ETS65407.1 - 6.4 7.4 11.7 1.1 9.9 0.5 3.3 3 0 0 3 3 3 0 UreF WD40 PF00400.32 ETS65408.1 - 3e-08 34.2 4.6 0.082 13.8 0.1 4.7 5 0 0 5 5 5 3 WD domain, G-beta repeat TFIIA PF03153.13 ETS65409.1 - 9.6e-08 32.4 20.0 9.6e-08 32.4 20.0 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit NUP50 PF08911.11 ETS65409.1 - 6.7e-07 29.9 0.4 6.7e-07 29.9 0.4 10.3 7 4 0 7 7 3 1 NUP50 (Nucleoporin 50 kDa) SDA1 PF05285.12 ETS65409.1 - 8.2e-05 22.2 19.8 0.00015 21.3 19.8 1.4 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETS65409.1 - 0.0016 16.8 26.7 0.0016 16.8 26.7 1.7 2 0 0 2 2 2 1 Nop14-like family RPN2_C PF18004.1 ETS65409.1 - 0.12 12.2 5.7 0.3 11.0 5.7 1.7 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 ETS65409.1 - 0.44 8.8 22.1 0.68 8.2 22.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 ETS65409.1 - 0.79 8.1 26.3 1.2 7.4 26.3 1.2 1 0 0 1 1 1 0 Mpp10 protein Vfa1 PF08432.10 ETS65409.1 - 1.2 9.4 9.8 0.38 11.1 6.4 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SAPS PF04499.15 ETS65409.1 - 1.8 7.2 10.3 2.4 6.8 10.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 ETS65409.1 - 4.3 6.0 8.5 7.3 5.3 8.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 ETS65409.1 - 6.5 6.5 8.7 14 5.4 8.7 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L1 PF00687.21 ETS65410.1 - 8.7e-48 162.8 3.5 1e-47 162.6 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DNA_pol_lambd_f PF10391.9 ETS65410.1 - 0.049 13.5 0.1 5.7 6.9 0.0 2.6 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Mod_r PF07200.13 ETS65410.1 - 0.053 13.6 1.8 0.16 12.1 0.3 2.0 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TetR PF13972.6 ETS65410.1 - 0.086 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional repressor Band_7 PF01145.25 ETS65411.1 - 1.2e-21 77.5 0.3 1.2e-21 77.5 0.3 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family AAA_12 PF13087.6 ETS65412.1 - 1.5e-45 155.3 0.0 2.2e-45 154.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 ETS65412.1 - 3.6e-44 151.0 0.0 1.8e-43 148.7 0.0 2.1 1 1 0 1 1 1 1 DNA replication factor Dna2 Actin PF00022.19 ETS65412.1 - 3.9e-33 114.7 0.0 1.2e-32 113.0 0.0 1.8 1 1 0 1 1 1 1 Actin AAA_11 PF13086.6 ETS65412.1 - 6.5e-22 78.6 0.0 2.8e-12 47.0 0.0 2.7 1 1 0 2 2 2 2 AAA domain AAA_30 PF13604.6 ETS65412.1 - 7.7e-12 45.3 0.0 2.5e-11 43.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETS65412.1 - 4.6e-07 30.3 0.0 2e-06 28.2 0.0 2.2 2 0 0 2 2 1 1 AAA domain Viral_helicase1 PF01443.18 ETS65412.1 - 0.00045 20.0 0.1 0.54 9.9 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase UvrD_C PF13361.6 ETS65412.1 - 0.0066 15.9 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain SRP54 PF00448.22 ETS65412.1 - 0.0086 15.7 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 ETS65412.1 - 0.014 15.6 0.0 0.076 13.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cas_Cas4 PF01930.17 ETS65412.1 - 0.016 15.3 0.7 0.035 14.2 0.0 1.9 2 0 0 2 2 1 0 Domain of unknown function DUF83 Helicase_RecD PF05127.14 ETS65412.1 - 0.023 14.6 0.0 0.16 11.8 0.0 2.3 2 0 0 2 2 2 0 Helicase AAA_16 PF13191.6 ETS65412.1 - 0.027 14.8 0.3 0.22 11.9 0.0 2.7 3 0 0 3 3 2 0 AAA ATPase domain ResIII PF04851.15 ETS65412.1 - 0.039 14.0 0.0 0.08 12.9 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 ETS65412.1 - 0.084 12.4 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 ETS65412.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein Apt1 PF10351.9 ETS65413.1 - 0.3 9.9 20.6 0.42 9.4 20.6 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ETS65413.1 - 3.3 7.5 26.1 5 6.9 26.1 1.3 1 0 0 1 1 1 0 SPX domain E1-E2_ATPase PF00122.20 ETS65414.1 - 9.7e-40 136.0 8.6 3e-39 134.4 5.7 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETS65414.1 - 1.1e-36 126.2 15.1 4.2e-35 121.1 3.6 3.1 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETS65414.1 - 4.1e-21 76.2 0.3 1.5e-09 38.5 0.3 3.6 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ETS65414.1 - 2.2e-13 49.7 0.0 4.5e-13 48.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ETS65414.1 - 2.6e-09 37.0 0.0 6.3e-09 35.8 0.0 1.7 1 1 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETS65414.1 - 0.0004 20.2 0.2 0.00076 19.3 0.2 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4149 PF13664.6 ETS65414.1 - 0.0009 19.5 2.4 0.095 13.0 0.1 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF2157 PF09925.9 ETS65414.1 - 0.0054 16.5 0.0 0.0054 16.5 0.0 3.4 3 1 0 3 3 3 1 Predicted membrane protein (DUF2157) HAD PF12710.7 ETS65414.1 - 0.036 14.5 0.0 0.42 11.0 0.0 2.7 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase DUF4411 PF14367.6 ETS65414.1 - 0.19 11.6 0.1 2.1 8.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4411) DUF2678 PF10856.8 ETS65414.1 - 0.42 10.6 2.7 3.9 7.5 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2678) DUF2207 PF09972.9 ETS65414.1 - 0.51 9.1 5.9 1.8 7.2 0.0 2.9 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) Ins_P5_2-kin PF06090.12 ETS65415.1 - 5.4e-67 226.6 0.0 6.6e-67 226.3 0.0 1.1 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Ribosomal_S3Ae PF01015.18 ETS65416.1 - 3.5e-91 304.3 2.8 4.1e-91 304.0 2.8 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Abhydro_lipase PF04083.16 ETS65416.1 - 0.015 14.9 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region ISAV_HA PF06215.11 ETS65416.1 - 0.036 13.2 0.1 0.05 12.7 0.1 1.1 1 0 0 1 1 1 0 Infectious salmon anaemia virus haemagglutinin YwhD PF08741.10 ETS65417.1 - 0.19 11.4 0.1 0.28 10.8 0.1 1.2 1 0 0 1 1 1 0 YwhD family Ribosomal_S7e PF01251.18 ETS65418.1 - 1.7e-78 262.7 0.6 2.4e-53 180.6 0.1 2.1 2 0 0 2 2 2 2 Ribosomal protein S7e RasGAP PF00616.19 ETS65419.1 - 1.7e-25 89.9 0.0 3e-25 89.2 0.0 1.4 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Glyoxalase_3 PF13468.6 ETS65420.1 - 1.9e-24 86.7 0.1 3e-23 82.8 0.0 2.4 2 1 0 2 2 2 1 Glyoxalase-like domain GYF PF02213.16 ETS65421.1 - 2.2e-06 27.2 0.0 5.1e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 GYF domain VPS53_C PF16854.5 ETS65421.1 - 0.28 11.0 0.1 0.49 10.2 0.1 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus Pkinase PF00069.25 ETS65422.1 - 1.8e-66 224.2 0.0 5.8e-35 120.9 0.0 3.4 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETS65422.1 - 1.2e-35 123.0 0.0 2.7e-16 59.6 0.0 3.6 3 1 0 3 3 3 3 Protein tyrosine kinase HGTP_anticodon2 PF12745.7 ETS65422.1 - 3e-17 63.0 7.5 4e-15 56.0 0.0 3.9 5 0 0 5 5 5 1 Anticodon binding domain of tRNAs tRNA-synt_His PF13393.6 ETS65422.1 - 6.8e-17 61.7 0.1 1.8e-16 60.3 0.1 1.6 1 0 0 1 1 1 1 Histidyl-tRNA synthetase RWD PF05773.22 ETS65422.1 - 2.5e-15 56.7 0.0 5.4e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 RWD domain Kinase-like PF14531.6 ETS65422.1 - 0.00051 19.4 0.0 0.024 14.0 0.0 2.5 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ETS65422.1 - 0.004 16.5 0.0 0.48 9.7 0.0 2.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-B_dimeris PF09026.10 ETS65422.1 - 0.0054 17.1 10.3 0.0054 17.1 2.0 3.6 3 0 0 3 3 3 1 Centromere protein B dimerisation domain APH PF01636.23 ETS65422.1 - 0.0099 15.8 0.0 0.0099 15.8 0.0 3.9 5 0 0 5 5 5 1 Phosphotransferase enzyme family FTA2 PF13095.6 ETS65422.1 - 0.02 14.5 0.0 5.2 6.6 0.0 2.9 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ETS65422.1 - 0.13 11.0 1.3 0.26 10.0 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase GCD14_N PF14801.6 ETS65423.1 - 0.012 15.5 0.1 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit N-term DPBB_1 PF03330.18 ETS65423.1 - 0.016 15.5 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 Lytic transglycolase Questin_oxidase PF14027.6 ETS65424.1 - 1.2e-71 242.0 2.7 1.2e-71 242.0 2.7 1.4 2 0 0 2 2 2 1 Questin oxidase-like DUF3140 PF11338.8 ETS65425.1 - 5.6e-33 113.2 3.6 5.6e-33 113.2 3.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3140) Med22 PF06179.12 ETS65425.1 - 4.5e-12 46.1 1.9 1.8e-11 44.2 1.9 2.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DUF3237 PF11578.8 ETS65426.1 - 3.1e-32 111.5 0.2 4.9e-32 110.8 0.2 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3237) Zn_clus PF00172.18 ETS65427.1 - 1.4e-05 25.1 9.4 2.8e-05 24.1 9.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_8 PF05148.15 ETS65428.1 - 7.4e-51 173.1 1.1 2.3e-25 89.8 0.5 3.6 2 2 0 2 2 2 2 Hypothetical methyltransferase CD99L2 PF12301.8 ETS65428.1 - 0.0014 19.0 4.4 0.0014 19.0 4.4 2.2 2 0 0 2 2 2 1 CD99 antigen like protein 2 Methyltransf_11 PF08241.12 ETS65428.1 - 0.0045 17.6 0.1 0.033 14.8 0.1 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETS65428.1 - 0.0055 17.4 0.4 0.17 12.6 0.1 3.3 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETS65428.1 - 0.078 12.8 0.0 0.88 9.4 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain DUF5582 PF17819.1 ETS65428.1 - 1.2 9.6 4.0 1.3 9.5 0.3 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5582) Methyltransf_32 PF13679.6 ETS65428.1 - 5.8 6.9 6.1 7.3 6.6 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain CDT1_C PF16679.5 ETS65429.1 - 3.3e-16 59.5 0.1 9.1e-16 58.1 0.1 1.8 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain Trp_repressor PF01371.19 ETS65429.1 - 0.18 11.9 0.1 0.41 10.8 0.1 1.6 1 0 0 1 1 1 0 Trp repressor protein DUF924 PF06041.11 ETS65430.1 - 8e-47 159.7 0.3 1e-46 159.3 0.3 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Forkhead PF00250.18 ETS65431.1 - 2.6e-18 66.0 0.0 4.3e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 ETS65431.1 - 0.16 12.3 0.0 0.66 10.4 0.0 1.9 1 1 0 1 1 1 0 FHA domain TFIIA PF03153.13 ETS65432.1 - 0.95 9.4 34.5 2.1 8.2 22.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Peptidase_S64 PF08192.11 ETS65432.1 - 7.1 5.0 12.9 13 4.1 12.9 1.4 1 0 0 1 1 1 0 Peptidase family S64 Ytp1 PF10355.9 ETS65433.1 - 4e-102 341.1 2.3 4e-102 341.1 2.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ETS65433.1 - 2.3e-17 62.7 0.4 2.3e-17 62.7 0.4 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Abhydrolase_3 PF07859.13 ETS65434.1 - 1.9e-22 80.2 0.3 5.7e-22 78.6 0.3 2.0 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETS65434.1 - 5.3e-13 48.6 0.0 2.2e-09 36.7 0.0 2.3 2 0 0 2 2 2 2 Steryl acetyl hydrolase COesterase PF00135.28 ETS65434.1 - 0.084 11.7 0.0 0.77 8.6 0.0 2.0 2 0 0 2 2 2 0 Carboxylesterase family Aminotran_1_2 PF00155.21 ETS65435.1 - 3.2e-74 250.3 0.0 5.3e-74 249.6 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II SSB PF00436.25 ETS65435.1 - 1.8e-12 47.2 0.0 3.5e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Single-strand binding protein family Aminotran_5 PF00266.19 ETS65435.1 - 3.9e-07 29.4 0.1 7e-07 28.5 0.1 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ETS65435.1 - 2.5e-05 23.0 0.0 0.00011 20.9 0.0 1.8 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Preseq_ALAS PF09029.10 ETS65435.1 - 0.0013 19.2 7.2 0.0045 17.5 4.1 2.9 1 1 1 2 2 2 1 5-aminolevulinate synthase presequence DegT_DnrJ_EryC1 PF01041.17 ETS65435.1 - 0.0017 17.8 0.2 0.0032 16.8 0.2 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family DUF3824 PF12868.7 ETS65435.1 - 0.019 15.6 0.4 0.019 15.6 0.4 2.3 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Beta_elim_lyase PF01212.21 ETS65435.1 - 0.022 14.0 0.3 0.046 13.0 0.3 1.5 1 1 0 1 1 1 0 Beta-eliminating lyase Ribosomal_L12 PF00542.19 ETS65436.1 - 2.6e-19 69.3 4.8 2.6e-19 69.3 4.8 2.4 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 ETS65436.1 - 2.4e-16 59.1 8.2 1.3e-15 56.8 4.7 2.5 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain GlcNAc_2-epim PF07221.11 ETS65436.1 - 0.013 14.7 0.4 0.019 14.2 0.4 1.2 1 0 0 1 1 1 0 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Ribosomal_60s PF00428.19 ETS65436.1 - 0.021 15.4 6.7 0.021 15.4 6.7 2.4 2 1 0 2 2 2 0 60s Acidic ribosomal protein EutN_CcmL PF03319.13 ETS65436.1 - 0.095 13.3 0.2 6.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation protein EutN/carboxysome DAO PF01266.24 ETS65437.1 - 1.7e-51 175.9 0.8 3.1e-51 175.0 0.8 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ETS65437.1 - 0.00068 19.1 0.2 0.0064 15.9 0.2 2.0 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETS65437.1 - 0.001 19.6 0.1 0.041 14.5 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETS65437.1 - 0.0014 17.8 0.2 0.0025 17.0 0.2 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETS65437.1 - 0.0031 16.8 0.0 0.0087 15.3 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETS65437.1 - 0.0048 17.1 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETS65437.1 - 0.028 13.7 0.1 0.1 11.8 0.0 1.8 2 0 0 2 2 2 0 Thi4 family Mqo PF06039.15 ETS65437.1 - 0.14 10.6 0.0 0.27 9.8 0.0 1.4 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) TrkA_N PF02254.18 ETS65437.1 - 0.16 12.2 0.0 0.42 10.9 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Snf7 PF03357.21 ETS65438.1 - 1.6e-43 148.3 13.2 1.6e-43 148.3 13.2 2.0 2 0 0 2 2 2 1 Snf7 FAM199X PF15814.5 ETS65438.1 - 0.015 14.4 0.1 0.022 13.8 0.1 1.3 1 0 0 1 1 1 0 Protein family FAM199X Xylo_C PF12529.8 ETS65438.1 - 0.023 14.3 0.4 0.031 13.9 0.4 1.2 1 0 0 1 1 1 0 Xylosyltransferase C terminal Ribosomal_60s PF00428.19 ETS65438.1 - 0.044 14.4 7.7 0.47 11.1 1.9 2.7 2 1 0 2 2 2 0 60s Acidic ribosomal protein SBDS_C PF09377.10 ETS65438.1 - 0.087 12.8 4.3 0.17 11.9 3.4 1.9 1 1 0 1 1 1 0 SBDS protein C-terminal domain Vps54_N PF10475.9 ETS65438.1 - 0.43 9.8 6.3 1.5 8.0 5.8 1.9 1 1 1 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex Atg14 PF10186.9 ETS65438.1 - 1.4 8.0 9.5 2 7.4 9.5 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RasGEF PF00617.19 ETS65439.1 - 5.2e-44 150.5 0.0 8.9e-44 149.8 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETS65439.1 - 1.7e-15 57.1 0.1 5e-15 55.6 0.1 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif MCM PF00493.23 ETS65440.1 - 1.2e-103 345.0 0.0 1.8e-103 344.5 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETS65440.1 - 4.3e-35 120.3 0.1 9.4e-35 119.2 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETS65440.1 - 9.8e-29 99.6 1.2 2.4e-28 98.4 0.5 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ETS65440.1 - 1.1e-12 48.4 0.0 2.3e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ETS65440.1 - 4.2e-06 26.3 0.0 0.0014 18.1 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETS65440.1 - 0.00034 20.6 0.0 0.00064 19.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ETS65440.1 - 0.0028 17.5 0.1 0.011 15.6 0.0 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TIG PF01833.24 ETS65441.1 - 4e-11 42.8 3.6 4e-11 42.8 3.6 3.0 3 0 0 3 3 3 1 IPT/TIG domain Ank_5 PF13857.6 ETS65441.1 - 3.7e-09 36.7 1.0 1e-08 35.3 0.5 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETS65441.1 - 6e-09 36.4 0.0 1.3e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETS65441.1 - 4.9e-08 33.4 0.8 4.9e-07 30.2 0.3 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETS65441.1 - 5.7e-08 32.4 0.4 0.01 16.3 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ETS65441.1 - 1.1e-06 28.8 0.7 0.023 15.1 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Glyco_transf_17 PF04724.13 ETS65442.1 - 7.6e-132 439.6 0.0 9.7e-132 439.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 17 SnoaL_4 PF13577.6 ETS65443.1 - 2.4e-10 40.6 0.2 5.3e-10 39.5 0.2 1.6 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.7 ETS65443.1 - 0.026 15.1 0.2 0.045 14.4 0.2 1.3 1 0 0 1 1 1 0 SnoaL-like domain PALP PF00291.25 ETS65444.1 - 1e-34 120.3 0.0 2.1e-34 119.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RMF PF04957.12 ETS65444.1 - 0.15 12.3 0.0 23 5.3 0.0 2.6 2 0 0 2 2 2 0 Ribosome modulation factor MFS_1 PF07690.16 ETS65445.1 - 1.9e-18 66.5 9.1 2.6e-18 66.1 9.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETS65445.1 - 5.8e-13 48.5 0.2 6.1e-13 48.4 0.2 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter TRI12 PF06609.13 ETS65445.1 - 9.1e-05 21.1 1.5 0.00011 20.8 1.5 1.0 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Moesziomyces_aphidis_DSM_70725-PseuAph1.0/GCA_000517465.1_PseuAph1.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Moesziomyces_aphidis_DSM_70725-PseuAph1.0/GCA_000517465.1_PseuAph1.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Moesziomyces_aphidis_DSM_70725-PseuAph1.0/GCA_000517465.1_PseuAph1.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Moesziomyces_aphidis_DSM_70725-PseuAph1.0/GCA_000517465.1_PseuAph1.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 00:58:30 2019 # [ok]